                               SEQUENCE LISTING

<110> REGENERON PHARMACEUTICALS, INC.
 
<120> CRISPR SAM BIOSENSOR CELL LINES AND METHODS OF USE THEREOF

<130> 67000-1122 WO

<140>
<141>

<150> 63/212,824
<151> 2021-06-21

<150> 63/120,403
<151> 2020-12-02

<160> 90    

<170> PatentIn version 3.5

<210> 1
<211> 20
<212> DNA
<213> Mus sp.

<400> 1
ggctgccaca ttgaccgcct                                                   20


<210> 2
<211> 20
<212> DNA
<213> Mus sp.

<400> 2
tgggccccag gcggtcaatg                                                   20


<210> 3
<211> 20
<212> DNA
<213> Mus sp.

<400> 3
ttaaatatac attgggcccc                                                   20


<210> 4
<211> 20
<212> DNA
<213> Mus sp.

<400> 4
ctctgcaatg ccggagccag                                                   20


<210> 5
<211> 20
<212> DNA
<213> Mus sp.

<400> 5
aacctgcatg ctgtttgttg                                                   20


<210> 6
<211> 21
<212> DNA
<213> Mus sp.

<400> 6
gctccacttt ggggccattc g                                                 21


<210> 7
<211> 20
<212> DNA
<213> Mus sp.

<400> 7
tctaccctag acccctcgaa                                                   20


<210> 8
<211> 20
<212> DNA
<213> Mus sp.

<400> 8
cccctccaag gtaatgtggt                                                   20


<210> 9
<211> 20
<212> DNA
<213> Mus sp.

<400> 9
gacccaccac attaccttgg                                                   20


<210> 10
<211> 20
<212> DNA
<213> Mus sp.

<400> 10
aatggcccca aagtggagtc                                                   20


<210> 11
<211> 20
<212> DNA
<213> Mus sp.

<400> 11
gtagatgatg tccccctgtg                                                   20


<210> 12
<211> 20
<212> DNA
<213> Mus sp.

<400> 12
tctgagccgc tgggactagc                                                   20


<210> 13
<211> 20
<212> DNA
<213> Mus sp.

<400> 13
agggagctga ataatacatc                                                   20


<210> 14
<211> 20
<212> DNA
<213> Mus sp.

<400> 14
gcaggacatt aatccccaca                                                   20


<210> 15
<211> 20
<212> DNA
<213> Mus sp.

<400> 15
gctgggtggc acggacagcg                                                   20


<210> 16
<211> 20
<212> DNA
<213> Mus sp.

<400> 16
aacaggagct ggccaactcc                                                   20


<210> 17
<211> 1471
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Met Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys 
1               5                   10                  15      


Lys Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Ala Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Ser  Ala Gly Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly 
    1385                 1390                 1395             


Gly Gly  Ser Gly Pro Lys Lys  Lys Arg Lys Val Ala  Ala Ala Gly 
    1400                 1405                 1410             


Ser Gly  Arg Ala Asp Ala Leu  Asp Asp Phe Asp Leu  Asp Met Leu 
    1415                 1420                 1425             


Gly Ser  Asp Ala Leu Asp Asp  Phe Asp Leu Asp Met  Leu Gly Ser 
    1430                 1435                 1440             


Asp Ala  Leu Asp Asp Phe Asp  Leu Asp Met Leu Gly  Ser Asp Ala 
    1445                 1450                 1455             


Leu Asp  Asp Phe Asp Leu Asp  Met Leu Ile Asn Cys  Thr 
    1460                 1465                 1470     


<210> 18
<211> 1384
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Met Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys 
1               5                   10                  15      


Lys Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Ala Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp 
    


<210> 19
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 19
Pro Lys Lys Lys Arg Lys Val 
1               5           


<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Pro Lys Lys Lys Arg Arg Val 
1               5           


<210> 21
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210> 22
<211> 62
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 22
Ala Ala Ala Gly Ser Gly Arg Ala Asp Ala Leu Asp Asp Phe Asp Leu 
1               5                   10                  15      


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
            20                  25                  30          


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
        35                  40                  45              


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Ile Asn Cys Thr 
    50                  55                  60          


<210> 23
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Gly Gly Gly Ser 
1               


<210> 24
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 24
Gly Gly Gly Gly Ser 
1               5   


<210> 25
<211> 473
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Gly Ser 
145                 150                 155                 160 


Pro Ser Gly Gln Ile Ser Asn Gln Ala Leu Ala Leu Ala Pro Ser Ser 
                165                 170                 175     


Ala Pro Val Leu Ala Gln Thr Met Val Pro Ser Ser Ala Met Val Pro 
            180                 185                 190         


Leu Ala Gln Pro Pro Ala Pro Ala Pro Val Leu Thr Pro Gly Pro Pro 
        195                 200                 205             


Gln Ser Leu Ser Ala Pro Val Pro Lys Ser Thr Gln Ala Gly Glu Gly 
    210                 215                 220                 


Thr Leu Ser Glu Ala Leu Leu His Leu Gln Phe Asp Ala Asp Glu Asp 
225                 230                 235                 240 


Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Gly Val Phe Thr Asp 
                245                 250                 255     


Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly 
            260                 265                 270         


Val Ser Met Ser His Ser Thr Ala Glu Pro Met Leu Met Glu Tyr Pro 
        275                 280                 285             


Glu Ala Ile Thr Arg Leu Val Thr Gly Ser Gln Arg Pro Pro Asp Pro 
    290                 295                 300                 


Ala Pro Thr Pro Leu Gly Thr Ser Gly Leu Pro Asn Gly Leu Ser Gly 
305                 310                 315                 320 


Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu 
                325                 330                 335     


Ser Gln Ile Ser Ser Ser Gly Gln Gly Gly Gly Gly Ser Gly Phe Ser 
            340                 345                 350         


Val Asp Thr Ser Ala Leu Leu Asp Leu Phe Ser Pro Ser Val Thr Val 
        355                 360                 365             


Pro Asp Met Ser Leu Pro Asp Leu Asp Ser Ser Leu Ala Ser Ile Gln 
    370                 375                 380                 


Glu Leu Leu Ser Pro Gln Glu Pro Pro Arg Pro Pro Glu Ala Glu Asn 
385                 390                 395                 400 


Ser Ser Pro Asp Ser Gly Lys Gln Leu Val His Tyr Thr Ala Gln Pro 
                405                 410                 415     


Leu Phe Leu Leu Asp Pro Gly Ser Val Asp Thr Gly Ser Asn Asp Leu 
            420                 425                 430         


Pro Val Leu Phe Glu Leu Gly Glu Gly Ser Tyr Phe Ser Glu Gly Asp 
        435                 440                 445             


Gly Phe Ala Glu Asp Pro Thr Ile Ser Leu Leu Thr Gly Ser Glu Pro 
    450                 455                 460                 


Pro Lys Ala Lys Asp Pro Thr Val Ser 
465                 470             


<210> 26
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 26
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr 
    130 


<210> 27
<211> 181
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 27
Pro Ser Gly Gln Ile Ser Asn Gln Ala Leu Ala Leu Ala Pro Ser Ser 
1               5                   10                  15      


Ala Pro Val Leu Ala Gln Thr Met Val Pro Ser Ser Ala Met Val Pro 
            20                  25                  30          


Leu Ala Gln Pro Pro Ala Pro Ala Pro Val Leu Thr Pro Gly Pro Pro 
        35                  40                  45              


Gln Ser Leu Ser Ala Pro Val Pro Lys Ser Thr Gln Ala Gly Glu Gly 
    50                  55                  60                  


Thr Leu Ser Glu Ala Leu Leu His Leu Gln Phe Asp Ala Asp Glu Asp 
65                  70                  75                  80  


Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Gly Val Phe Thr Asp 
                85                  90                  95      


Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly 
            100                 105                 110         


Val Ser Met Ser His Ser Thr Ala Glu Pro Met Leu Met Glu Tyr Pro 
        115                 120                 125             


Glu Ala Ile Thr Arg Leu Val Thr Gly Ser Gln Arg Pro Pro Asp Pro 
    130                 135                 140                 


Ala Pro Thr Pro Leu Gly Thr Ser Gly Leu Pro Asn Gly Leu Ser Gly 
145                 150                 155                 160 


Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu 
                165                 170                 175     


Ser Gln Ile Ser Ser 
            180     


<210> 28
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 28
Gly Phe Ser Val Asp Thr Ser Ala Leu Leu Asp Leu Phe Ser Pro Ser 
1               5                   10                  15      


Val Thr Val Pro Asp Met Ser Leu Pro Asp Leu Asp Ser Ser Leu Ala 
            20                  25                  30          


Ser Ile Gln Glu Leu Leu Ser Pro Gln Glu Pro Pro Arg Pro Pro Glu 
        35                  40                  45              


Ala Glu Asn Ser Ser Pro Asp Ser Gly Lys Gln Leu Val His Tyr Thr 
    50                  55                  60                  


Ala Gln Pro Leu Phe Leu Leu Asp Pro Gly Ser Val Asp Thr Gly Ser 
65                  70                  75                  80  


Asn Asp Leu Pro Val Leu Phe Glu Leu Gly Glu Gly Ser Tyr Phe Ser 
                85                  90                  95      


Glu Gly Asp Gly Phe Ala Glu Asp Pro Thr Ile Ser Leu Leu Thr Gly 
            100                 105                 110         


Ser Glu Pro Pro Lys Ala Lys Asp Pro Thr Val Ser 
        115                 120                 


<210> 29
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 29
guuuuagagc uaugcu                                                       16


<210> 30
<211> 67
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 30
agcauagcaa guuaaaauaa ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg       60

gugcuuu                                                                 67


<210> 31
<211> 72
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 31
aaacagcaua gcaaguuaaa auaaggcuag uccguuauca acuugaaaaa guggcaccga       60

gucggugcuu uu                                                           72


<210> 32
<211> 82
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 32
guuggaacca uucaaaacag cauagcaagu uaaaauaagg cuaguccguu aucaacuuga       60

aaaaguggca ccgagucggu gc                                                82


<210> 33
<211> 77
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 33
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcu                                                      77


<210> 34
<211> 82
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 34
guuggaacca uucaaaacag cauagcaagu uaaaauaagg cuaguccguu aucaacuuga       60

aaaaguggca ccgagucggu gc                                                82


<210> 35
<211> 76
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 35
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugc                                                       76


<210> 36
<211> 86
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 36
guuuaagagc uaugcuggaa acagcauagc aaguuuaaau aaggcuaguc cguuaucaac       60

uugaaaaagu ggcaccgagu cggugc                                            86


<210> 37
<211> 83
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 37
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu uuu                                               83


<210> 38
<211> 80
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 38
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu                                                   80


<210> 39
<211> 92
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 39
guuuaagagc uaugcuggaa acagcauagc aaguuuaaau aaggcuaguc cguuaucaac       60

uugaaaaagu ggcaccgagu cggugcuuuu uu                                     92


<210> 40
<211> 34
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 40
ggccaacaug aggaucaccc augucugcag ggcc                                   34


<210> 41
<211> 137
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 41
guuuuagagc uaggccaaca ugaggaucac ccaugucugc agggccuagc aaguuaaaau       60

aaggcuaguc cguuaucaac uuggccaaca ugaggaucac ccaugucugc agggccaagu      120

ggcaccgagu cggugcu                                                     137


<210> 42
<211> 139
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 42
guuuuagagc uaggccaaca ugaggaucac ccaugucugc agggccuagc aaguuaaaau       60

aaggcuaguc cguuaucaac uuggccaaca ugaggaucac ccaugucugc agggccaagu      120

ggcaccgagu cggugcuuu                                                   139


<210> 43
<211> 157
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, g, or u

<400> 43
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaggccaaca ugaggaucac ccaugucugc       60

agggccuagc aaguuaaaau aaggcuaguc cguuaucaac uuggccaaca ugaggaucac      120

ccaugucugc agggccaagu ggcaccgagu cggugcu                               157


<210> 44
<211> 159
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, g, or u

<400> 44
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaggccaaca ugaggaucac ccaugucugc       60

agggccuagc aaguuaaaau aaggcuaguc cguuaucaac uuggccaaca ugaggaucac      120

ccaugucugc agggccaagu ggcaccgagu cggugcuuu                             159


<210> 45
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (2)..(21)
<223> a, c, g, or t

<400> 45
gnnnnnnnnn nnnnnnnnnn ngg                                               23


<210> 46
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(21)
<223> a, c, g, or t

<400> 46
nnnnnnnnnn nnnnnnnnnn ngg                                               23


<210> 47
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (3)..(23)
<223> a, c, g, or t

<400> 47
ggnnnnnnnn nnnnnnnnnn nnngg                                             25


<210> 48
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 48
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210> 49
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 49
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210> 50
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 50
Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210> 51
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 51
Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210> 52
<211> 4152
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 52
atgaaaaggc cggcggccac gaaaaaggcc ggccaggcaa aaaagaaaaa ggacaagaag       60

tacagcatcg gcctggccat cggcaccaac tctgtgggct gggccgtgat caccgacgag      120

tacaaggtgc ccagcaagaa attcaaggtg ctgggcaaca ccgaccggca cagcatcaag      180

aagaacctga tcggagccct gctgttcgac agcggcgaaa cagccgaggc cacccggctg      240

aagagaaccg ccagaagaag atacaccaga cggaagaacc ggatctgcta tctgcaagag      300

atcttcagca acgagatggc caaggtggac gacagcttct tccacagact ggaagagtcc      360

ttcctggtgg aagaggataa gaagcacgag cggcacccca tcttcggcaa catcgtggac      420

gaggtggcct accacgagaa gtaccccacc atctaccacc tgagaaagaa actggtggac      480

agcaccgaca aggccgacct gcggctgatc tatctggccc tggcccacat gatcaagttc      540

cggggccact tcctgatcga gggcgacctg aaccccgaca acagcgacgt ggacaagctg      600

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg aaaaccccat caacgccagc      660

ggcgtggacg ccaaggccat cctgtctgcc agactgagca agagcagacg gctggaaaat      720

ctgatcgccc agctgcccgg cgagaagaag aatggcctgt tcggcaacct gattgccctg      780

agcctgggcc tgacccccaa cttcaagagc aacttcgacc tggccgagga tgccaaactg      840

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac      900

cagtacgccg acctgtttct ggccgccaag aacctgtccg acgccatcct gctgagcgac      960

atcctgagag tgaacaccga gatcaccaag gcccccctga gcgcctctat gatcaagaga     1020

tacgacgagc accaccagga cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct     1080

gagaagtaca aagagatttt cttcgaccag agcaagaacg gctacgccgg ctacattgac     1140

ggcggagcca gccaggaaga gttctacaag ttcatcaagc ccatcctgga aaagatggac     1200

ggcaccgagg aactgctcgt gaagctgaac agagaggacc tgctgcggaa gcagcggacc     1260

ttcgacaacg gcagcatccc ccaccagatc cacctgggag agctgcacgc cattctgcgg     1320

cggcaggaag atttttaccc attcctgaag gacaaccggg aaaagatcga gaagatcctg     1380

accttccgca tcccctacta cgtgggccct ctggccaggg gaaacagcag attcgcctgg     1440

atgaccagaa agagcgagga aaccatcacc ccctggaact tcgaggaagt ggtggacaag     1500

ggcgcttccg cccagagctt catcgagcgg atgaccaact tcgataagaa cctgcccaac     1560

gagaaggtgc tgcccaagca cagcctgctg tacgagtact tcaccgtgta taacgagctg     1620

accaaagtga aatacgtgac cgagggaatg agaaagcccg ccttcctgag cggcgagcag     1680

aaaaaggcca tcgtggacct gctgttcaag accaaccgga aagtgaccgt gaagcagctg     1740

aaagaggact acttcaagaa aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa     1800

gatcggttca acgcctccct gggcacatac cacgatctgc tgaaaattat caaggacaag     1860

gacttcctgg acaatgagga aaacgaggac attctggaag atatcgtgct gaccctgaca     1920

ctgtttgagg acagagagat gatcgaggaa cggctgaaaa cctatgccca cctgttcgac     1980

gacaaagtga tgaagcagct gaagcggcgg agatacaccg gctggggcag gctgagccgg     2040

aagctgatca acggcatccg ggacaagcag tccggcaaga caatcctgga tttcctgaag     2100

tccgacggct tcgccaacag aaacttcatg cagctgatcc acgacgacag cctgaccttt     2160

aaagaggaca tccagaaagc ccaggtgtcc ggccagggcg atagcctgca cgagcacatt     2220

gccaatctgg ccggcagccc cgccattaag aagggcatcc tgcagacagt gaaggtggtg     2280

gacgagctcg tgaaagtgat gggccggcac aagcccgaga acatcgtgat cgaaatggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaat gaagcggatc     2400

gaagagggca tcaaagagct gggcagccag atcctgaaag aacaccccgt ggaaaacacc     2460

cagctgcaga acgagaagct gtacctgtac tacctgcaga atgggcggga tatgtacgtg     2520

gaccaggaac tggacatcaa ccggctgtcc gactacgatg tggaccacat cgtgcctcag     2580

agctttctga aggacgactc catcgacaac aaggtgctga ccagaagcga caaggcccgg     2640

ggcaagagcg acaacgtgcc ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg     2700

cagctgctga acgccaagct gattacccag agaaagttcg acaatctgac caaggccgag     2760

agaggcggcc tgagcgaact ggataaggcc ggcttcatca agagacagct ggtggaaacc     2820

cggcagatca caaagcacgt ggcacagatc ctggactccc ggatgaacac taagtacgac     2880

gagaatgaca agctgatccg ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc     2940

gatttccgga aggatttcca gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc     3000

cacgacgcct acctgaacgc cgtcgtggga accgccctga tcaaaaagta ccctaagctg     3060

gaaagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgcggaagat gatcgccaag     3120

agcgagcagg aaatcggcaa ggctaccgcc aagtacttct tctacagcaa catcatgaac     3180

tttttcaaga ccgagattac cctggccaac ggcgagatcc ggaagcggcc tctgatcgag     3240

acaaacggcg aaaccgggga gatcgtgtgg gataagggcc gggattttgc caccgtgcgg     3300

aaagtgctga gcatgcccca agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc     3360

ttcagcaaag agtctatcct gcccaagagg aacagcgata agctgatcgc cagaaagaag     3420

gactgggacc ctaagaagta cggcggcttc gacagcccca ccgtggccta ttctgtgctg     3480

gtggtggcca aagtggaaaa gggcaagtcc aagaaactga agagtgtgaa agagctgctg     3540

gggatcacca tcatggaaag aagcagcttc gagaagaatc ccatcgactt tctggaagcc     3600

aagggctaca aagaagtgaa aaaggacctg atcatcaagc tgcctaagta ctccctgttc     3660

gagctggaaa acggccggaa gagaatgctg gcctctgccg gcgaactgca gaagggaaac     3720

gaactggccc tgccctccaa atatgtgaac ttcctgtacc tggccagcca ctatgagaag     3780

ctgaagggct cccccgagga taatgagcag aaacagctgt ttgtggaaca gcacaagcac     3840

tacctggacg agatcatcga gcagatcagc gagttctcca agagagtgat cctggccgac     3900

gctaatctgg acaaagtgct gtccgcctac aacaagcacc gggataagcc catcagagag     3960

caggccgaga atatcatcca cctgtttacc ctgaccaatc tgggagcccc tgccgccttc     4020

aagtactttg acaccaccat cgaccggaag aggtacacca gcaccaaaga ggtgctggac     4080

gccaccctga tccaccagag catcaccggc ctgtacgaga cacggatcga cctgtctcag     4140

ctgggaggcg ac                                                         4152


<210> 53
<211> 4414
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 53
atgaaaaggc cggcggccac gaaaaaggcc ggccaggcaa aaaagaaaaa ggacaagaag       60

tacagcatcg gcctggccat cggcaccaac tctgtgggct gggccgtgat caccgacgag      120

tacaaggtgc ccagcaagaa attcaaggtg ctgggcaaca ccgaccggca cagcatcaag      180

aagaacctga tcggagccct gctgttcgac agcggcgaaa cagccgaggc cacccggctg      240

aagagaaccg ccagaagaag atacaccaga cggaagaacc ggatctgcta tctgcaagag      300

atcttcagca acgagatggc caaggtggac gacagcttct tccacagact ggaagagtcc      360

ttcctggtgg aagaggataa gaagcacgag cggcacccca tcttcggcaa catcgtggac      420

gaggtggcct accacgagaa gtaccccacc atctaccacc tgagaaagaa actggtggac      480

agcaccgaca aggccgacct gcggctgatc tatctggccc tggcccacat gatcaagttc      540

cggggccact tcctgatcga gggcgacctg aaccccgaca acagcgacgt ggacaagctg      600

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg aaaaccccat caacgccagc      660

ggcgtggacg ccaaggccat cctgtctgcc agactgagca agagcagacg gctggaaaat      720

ctgatcgccc agctgcccgg cgagaagaag aatggcctgt tcggcaacct gattgccctg      780

agcctgggcc tgacccccaa cttcaagagc aacttcgacc tggccgagga tgccaaactg      840

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac      900

cagtacgccg acctgtttct ggccgccaag aacctgtccg acgccatcct gctgagcgac      960

atcctgagag tgaacaccga gatcaccaag gcccccctga gcgcctctat gatcaagaga     1020

tacgacgagc accaccagga cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct     1080

gagaagtaca aagagatttt cttcgaccag agcaagaacg gctacgccgg ctacattgac     1140

ggcggagcca gccaggaaga gttctacaag ttcatcaagc ccatcctgga aaagatggac     1200

ggcaccgagg aactgctcgt gaagctgaac agagaggacc tgctgcggaa gcagcggacc     1260

ttcgacaacg gcagcatccc ccaccagatc cacctgggag agctgcacgc cattctgcgg     1320

cggcaggaag atttttaccc attcctgaag gacaaccggg aaaagatcga gaagatcctg     1380

accttccgca tcccctacta cgtgggccct ctggccaggg gaaacagcag attcgcctgg     1440

atgaccagaa agagcgagga aaccatcacc ccctggaact tcgaggaagt ggtggacaag     1500

ggcgcttccg cccagagctt catcgagcgg atgaccaact tcgataagaa cctgcccaac     1560

gagaaggtgc tgcccaagca cagcctgctg tacgagtact tcaccgtgta taacgagctg     1620

accaaagtga aatacgtgac cgagggaatg agaaagcccg ccttcctgag cggcgagcag     1680

aaaaaggcca tcgtggacct gctgttcaag accaaccgga aagtgaccgt gaagcagctg     1740

aaagaggact acttcaagaa aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa     1800

gatcggttca acgcctccct gggcacatac cacgatctgc tgaaaattat caaggacaag     1860

gacttcctgg acaatgagga aaacgaggac attctggaag atatcgtgct gaccctgaca     1920

ctgtttgagg acagagagat gatcgaggaa cggctgaaaa cctatgccca cctgttcgac     1980

gacaaagtga tgaagcagct gaagcggcgg agatacaccg gctggggcag gctgagccgg     2040

aagctgatca acggcatccg ggacaagcag tccggcaaga caatcctgga tttcctgaag     2100

tccgacggct tcgccaacag aaacttcatg cagctgatcc acgacgacag cctgaccttt     2160

aaagaggaca tccagaaagc ccaggtgtcc ggccagggcg atagcctgca cgagcacatt     2220

gccaatctgg ccggcagccc cgccattaag aagggcatcc tgcagacagt gaaggtggtg     2280

gacgagctcg tgaaagtgat gggccggcac aagcccgaga acatcgtgat cgaaatggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaat gaagcggatc     2400

gaagagggca tcaaagagct gggcagccag atcctgaaag aacaccccgt ggaaaacacc     2460

cagctgcaga acgagaagct gtacctgtac tacctgcaga atgggcggga tatgtacgtg     2520

gaccaggaac tggacatcaa ccggctgtcc gactacgatg tggaccacat cgtgcctcag     2580

agctttctga aggacgactc catcgacaac aaggtgctga ccagaagcga caaggcccgg     2640

ggcaagagcg acaacgtgcc ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg     2700

cagctgctga acgccaagct gattacccag agaaagttcg acaatctgac caaggccgag     2760

agaggcggcc tgagcgaact ggataaggcc ggcttcatca agagacagct ggtggaaacc     2820

cggcagatca caaagcacgt ggcacagatc ctggactccc ggatgaacac taagtacgac     2880

gagaatgaca agctgatccg ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc     2940

gatttccgga aggatttcca gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc     3000

cacgacgcct acctgaacgc cgtcgtggga accgccctga tcaaaaagta ccctaagctg     3060

gaaagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgcggaagat gatcgccaag     3120

agcgagcagg aaatcggcaa ggctaccgcc aagtacttct tctacagcaa catcatgaac     3180

tttttcaaga ccgagattac cctggccaac ggcgagatcc ggaagcggcc tctgatcgag     3240

acaaacggcg aaaccgggga gatcgtgtgg gataagggcc gggattttgc caccgtgcgg     3300

aaagtgctga gcatgcccca agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc     3360

ttcagcaaag agtctatcct gcccaagagg aacagcgata agctgatcgc cagaaagaag     3420

gactgggacc ctaagaagta cggcggcttc gacagcccca ccgtggccta ttctgtgctg     3480

gtggtggcca aagtggaaaa gggcaagtcc aagaaactga agagtgtgaa agagctgctg     3540

gggatcacca tcatggaaag aagcagcttc gagaagaatc ccatcgactt tctggaagcc     3600

aagggctaca aagaagtgaa aaaggacctg atcatcaagc tgcctaagta ctccctgttc     3660

gagctggaaa acggccggaa gagaatgctg gcctctgccg gcgaactgca gaagggaaac     3720

gaactggccc tgccctccaa atatgtgaac ttcctgtacc tggccagcca ctatgagaag     3780

ctgaagggct cccccgagga taatgagcag aaacagctgt ttgtggaaca gcacaagcac     3840

tacctggacg agatcatcga gcagatcagc gagttctcca agagagtgat cctggccgac     3900

gctaatctgg acaaagtgct gtccgcctac aacaagcacc gggataagcc catcagagag     3960

caggccgaga atatcatcca cctgtttacc ctgaccaatc tgggagcccc tgccgccttc     4020

aagtactttg acaccaccat cgaccggaag aggtacacca gcaccaaaga ggtgctggac     4080

gccaccctga tccaccagag catcaccggc ctgtacgaga cacggatcga cctgtctcag     4140

ctgggaggcg acagcgctgg aggaggtgga agcggaggag gaggaagcgg aggaggaggt     4200

agcggaccta agaaaaagag gaaggtggcg gccgctggat ccggacgggc tgacgcattg     4260

gacgattttg atctggatat gctgggaagt gacgccctcg atgattttga ccttgacatg     4320

cttggttcgg atgcccttga tgactttgac ctcgacatgc tcggcagtga cgcccttgat     4380

gatttcgacc tggacatgct gattaactgt acag                                 4414


<210> 54
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 54
atggcttcaa actttactca gttcgtgctc gtggacaatg gtgggacagg ggatgtgaca       60

gtggctcctt ctaatttcgc taatggggtg gcagagtgga tcagctccaa ctcacggagc      120

caggcctaca aggtgacatg cagcgtcagg cagtctagtg cccagaagag aaagtatacc      180

atcaaggtgg aggtccccaa agtggctacc cagacagtgg gcggagtcga actgcctgtc      240

gccgcttgga ggtcctacct gaacatggag ctcactatcc caattttcgc taccaattct      300

gactgtgaac tcatcgtgaa ggcaatgcag gggctcctca aagacggtaa tcctatccct      360

tccgccatcg ccgctaactc aggtatctac                                       390


<210> 55
<211> 1419
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 55
atggcttcaa actttactca gttcgtgctc gtggacaatg gtgggacagg ggatgtgaca       60

gtggctcctt ctaatttcgc taatggggtg gcagagtgga tcagctccaa ctcacggagc      120

caggcctaca aggtgacatg cagcgtcagg cagtctagtg cccagaagag aaagtatacc      180

atcaaggtgg aggtccccaa agtggctacc cagacagtgg gcggagtcga actgcctgtc      240

gccgcttgga ggtcctacct gaacatggag ctcactatcc caattttcgc taccaattct      300

gactgtgaac tcatcgtgaa ggcaatgcag gggctcctca aagacggtaa tcctatccct      360

tccgccatcg ccgctaactc aggtatctac agcgctggag gaggtggaag cggaggagga      420

ggaagcggag gaggaggtag cggacctaag aaaaagagga aggtggcggc cgctggatcc      480

ccttcagggc agatcagcaa ccaggccctg gctctggccc ctagctccgc tccagtgctg      540

gcccagacta tggtgccctc tagtgctatg gtgcctctgg cccagccacc tgctccagcc      600

cctgtgctga ccccaggacc accccagtca ctgagcgctc cagtgcccaa gtctacacag      660

gccggcgagg ggactctgag tgaagctctg ctgcacctgc agttcgacgc tgatgaggac      720

ctgggagctc tgctggggaa cagcaccgat cccggagtgt tcacagatct ggcctccgtg      780

gacaactctg agtttcagca gctgctgaat cagggcgtgt ccatgtctca tagtacagcc      840

gaaccaatgc tgatggagta ccccgaagcc attacccggc tggtgaccgg cagccagcgg      900

ccccccgacc ccgctccaac tcccctggga accagcggcc tgcctaatgg gctgtccgga      960

gatgaagact tctcaagcat cgctgatatg gactttagtg ccctgctgtc acagatttcc     1020

tctagtgggc agggaggagg tggaagcggc ttcagcgtgg acaccagtgc cctgctggac     1080

ctgttcagcc cctcggtgac cgtgcccgac atgagcctgc ctgaccttga cagcagcctg     1140

gccagtatcc aagagctcct gtctccccag gagcccccca ggcctcccga ggcagagaac     1200

agcagcccgg attcagggaa gcagctggtg cactacacag cgcagccgct gttcctgctg     1260

gaccccggct ccgtggacac cgggagcaac gacctgccgg tgctgtttga gctgggagag     1320

ggctcctact tctccgaagg ggacggcttc gccgaggacc ccaccatctc cctgctgaca     1380

ggctcggagc ctcccaaagc caaggacccc actgtctcc                            1419


<210> 56
<211> 187
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 56
gcggccgctg gatccggacg ggctgacgca ttggacgatt ttgatctgga tatgctggga       60

agtgacgccc tcgatgattt tgaccttgac atgcttggtt cggatgccct tgatgacttt      120

gacctcgaca tgctcggcag tgacgccctt gatgatttcg acctggacat gctgattaac      180

tgtacag                                                                187


<210> 57
<211> 543
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 57
ccttcagggc agatcagcaa ccaggccctg gctctggccc ctagctccgc tccagtgctg       60

gcccagacta tggtgccctc tagtgctatg gtgcctctgg cccagccacc tgctccagcc      120

cctgtgctga ccccaggacc accccagtca ctgagcgctc cagtgcccaa gtctacacag      180

gccggcgagg ggactctgag tgaagctctg ctgcacctgc agttcgacgc tgatgaggac      240

ctgggagctc tgctggggaa cagcaccgat cccggagtgt tcacagatct ggcctccgtg      300

gacaactctg agtttcagca gctgctgaat cagggcgtgt ccatgtctca tagtacagcc      360

gaaccaatgc tgatggagta ccccgaagcc attacccggc tggtgaccgg cagccagcgg      420

ccccccgacc ccgctccaac tcccctggga accagcggcc tgcctaatgg gctgtccgga      480

gatgaagact tctcaagcat cgctgatatg gactttagtg ccctgctgtc acagatttcc      540

tct                                                                    543


<210> 58
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 58
ggcttcagcg tggacaccag tgccctgctg gacctgttca gcccctcggt gaccgtgccc       60

gacatgagcc tgcctgacct tgacagcagc ctggccagta tccaagagct cctgtctccc      120

caggagcccc ccaggcctcc cgaggcagag aacagcagcc cggattcagg gaagcagctg      180

gtgcactaca cagcgcagcc gctgttcctg ctggaccccg gctccgtgga caccgggagc      240

aacgacctgc cggtgctgtt tgagctggga gagggctcct acttctccga aggggacggc      300

ttcgccgagg accccaccat ctccctgctg acaggctcgg agcctcccaa agccaaggac      360

cccactgtct cc                                                          372


<210> 59
<211> 9043
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (1)..(34)
<223> /note="First loxP site"

<220>
<221> misc_feature
<222> (125 )..(928)
<223> /note="Sequence encoding neomycin phosphotransferase for 
      resistance to neomycin family antibiotics"

<220>
<221> misc_feature
<222> (937)..(2190)
<223> /note="Polyadenylation signal"

<220>
<221> misc_feature
<222> (2218)..(2251)
<223> /note="Second loxP site"

<220>
<221> misc_feature
<222> (2306)..(6457)
<223> /note="Codon-optimized dCas9 coding sequence"

<220>
<221> misc_feature
<222> (2309)..(2356)
<223> /note="NLS"

<220>
<221> misc_feature
<222> (6512 )..(6532)
<223> /note="NLS"

<220>
<221> misc_feature
<222> (6533)..(6719)
<223> /note="VP64"

<220>
<221> misc_feature
<222> (6719)..(6781)
<223> /note="T2A coding sequence with 5' GSG"

<220>
<221> misc_feature
<222> (6782)..(7171)
<223> /note="MCP"

<220>
<221> misc_feature
<222> (7226)..(7246)
<223> /note="NLS"

<220>
<221> misc_feature
<222> (7262)..(7804)
<223> /note="p65"

<220>
<221> misc_feature
<222> (7829)..(8200)
<223> /note="HSF1"

<220>
<221> misc_feature
<222> (8224)..(8820)
<223> /note="Woodchuck hepatitis virus posttranscriptional regulatory 
      element (WPRE)"

<400> 59
ataacttcgt ataatgtatg ctatacgaag ttattaggtc cctcgacctg caggaattgt       60

tgacaattaa tcatcggcat agtatatcgg catagtataa tacgacaagg tgaggaacta      120

aaccatggga tcggccattg aacaagatgg attgcacgca ggttctccgg ccgcttgggt      180

ggagaggcta ttcggctatg actgggcaca acagacaatc ggctgctctg atgccgccgt      240

gttccggctg tcagcgcagg ggcgcccggt tctttttgtc aagaccgacc tgtccggtgc      300

cctgaatgaa ctgcaggacg aggcagcgcg gctatcgtgg ctggccacga cgggcgttcc      360

ttgcgcagct gtgctcgacg ttgtcactga agcgggaagg gactggctgc tattgggcga      420

agtgccgggg caggatctcc tgtcatctca ccttgctcct gccgagaaag tatccatcat      480

ggctgatgca atgcggcggc tgcatacgct tgatccggct acctgcccat tcgaccacca      540

agcgaaacat cgcatcgagc gagcacgtac tcggatggaa gccggtcttg tcgatcagga      600

tgatctggac gaagagcatc aggggctcgc gccagccgaa ctgttcgcca ggctcaaggc      660

gcgcatgccc gacggcgatg atctcgtcgt gacccatggc gatgcctgct tgccgaatat      720

catggtggaa aatggccgct tttctggatt catcgactgt ggccggctgg gtgtggcgga      780

ccgctatcag gacatagcgt tggctacccg tgatattgct gaagagcttg gcggcgaatg      840

ggctgaccgc ttcctcgtgc tttacggtat cgccgctccc gattcgcagc gcatcgcctt      900

ctatcgcctt cttgacgagt tcttctgagg ggatccgctg taagtctgca gaaattgatg      960

atctattaaa caataaagat gtccactaaa atggaagttt ttcctgtcat actttgttaa     1020

gaagggtgag aacagagtac ctacattttg aatggaagga ttggagctac gggggtgggg     1080

gtggggtggg attagataaa tgcctgctct ttactgaagg ctctttacta ttgctttatg     1140

ataatgtttc atagttggat atcataattt aaacaagcaa aaccaaatta agggccagct     1200

cattcctccc actcatgatc tatagatcta tagatctctc gtgggatcat tgtttttctc     1260

ttgattccca ctttgtggtt ctaagtactg tggtttccaa atgtgtcagt ttcatagcct     1320

gaagaacgag atcagcagcc tctgttccac atacacttca ttctcagtat tgttttgcca     1380

agttctaatt ccatcagaag cttgcagatc tgcgactcta gaggatctgc gactctagag     1440

gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca     1500

cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc     1560

agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt     1620

ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat     1680

ctgcgactct agaggatcat aatcagccat accacatttg tagaggtttt acttgcttta     1740

aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt     1800

aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca     1860

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct     1920

tatcatgtct ggatctgcga ctctagagga tcataatcag ccataccaca tttgtagagg     1980

ttttacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg     2040

caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca     2100

tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac     2160

tcatcaatgt atcttatcat gtctggatcc ccatcaagct gatccggaac ccttaatata     2220

acttcgtata atgtatgcta tacgaagtta ttaggtccct cgacctgcag cccaagctag     2280

tgcccgggaa ttcgctaggg ccaccatgaa aaggccggcg gccacgaaaa aggccggcca     2340

ggcaaaaaag aaaaaggaca agaagtacag catcggcctg gccatcggca ccaactctgt     2400

gggctgggcc gtgatcaccg acgagtacaa ggtgcccagc aagaaattca aggtgctggg     2460

caacaccgac cggcacagca tcaagaagaa cctgatcgga gccctgctgt tcgacagcgg     2520

cgaaacagcc gaggccaccc ggctgaagag aaccgccaga agaagataca ccagacggaa     2580

gaaccggatc tgctatctgc aagagatctt cagcaacgag atggccaagg tggacgacag     2640

cttcttccac agactggaag agtccttcct ggtggaagag gataagaagc acgagcggca     2700

ccccatcttc ggcaacatcg tggacgaggt ggcctaccac gagaagtacc ccaccatcta     2760

ccacctgaga aagaaactgg tggacagcac cgacaaggcc gacctgcggc tgatctatct     2820

ggccctggcc cacatgatca agttccgggg ccacttcctg atcgagggcg acctgaaccc     2880

cgacaacagc gacgtggaca agctgttcat ccagctggtg cagacctaca accagctgtt     2940

cgaggaaaac cccatcaacg ccagcggcgt ggacgccaag gccatcctgt ctgccagact     3000

gagcaagagc agacggctgg aaaatctgat cgcccagctg cccggcgaga agaagaatgg     3060

cctgttcggc aacctgattg ccctgagcct gggcctgacc cccaacttca agagcaactt     3120

cgacctggcc gaggatgcca aactgcagct gagcaaggac acctacgacg acgacctgga     3180

caacctgctg gcccagatcg gcgaccagta cgccgacctg tttctggccg ccaagaacct     3240

gtccgacgcc atcctgctga gcgacatcct gagagtgaac accgagatca ccaaggcccc     3300

cctgagcgcc tctatgatca agagatacga cgagcaccac caggacctga ccctgctgaa     3360

agctctcgtg cggcagcagc tgcctgagaa gtacaaagag attttcttcg accagagcaa     3420

gaacggctac gccggctaca ttgacggcgg agccagccag gaagagttct acaagttcat     3480

caagcccatc ctggaaaaga tggacggcac cgaggaactg ctcgtgaagc tgaacagaga     3540

ggacctgctg cggaagcagc ggaccttcga caacggcagc atcccccacc agatccacct     3600

gggagagctg cacgccattc tgcggcggca ggaagatttt tacccattcc tgaaggacaa     3660

ccgggaaaag atcgagaaga tcctgacctt ccgcatcccc tactacgtgg gccctctggc     3720

caggggaaac agcagattcg cctggatgac cagaaagagc gaggaaacca tcaccccctg     3780

gaacttcgag gaagtggtgg acaagggcgc ttccgcccag agcttcatcg agcggatgac     3840

caacttcgat aagaacctgc ccaacgagaa ggtgctgccc aagcacagcc tgctgtacga     3900

gtacttcacc gtgtataacg agctgaccaa agtgaaatac gtgaccgagg gaatgagaaa     3960

gcccgccttc ctgagcggcg agcagaaaaa ggccatcgtg gacctgctgt tcaagaccaa     4020

ccggaaagtg accgtgaagc agctgaaaga ggactacttc aagaaaatcg agtgcttcga     4080

ctccgtggaa atctccggcg tggaagatcg gttcaacgcc tccctgggca cataccacga     4140

tctgctgaaa attatcaagg acaaggactt cctggacaat gaggaaaacg aggacattct     4200

ggaagatatc gtgctgaccc tgacactgtt tgaggacaga gagatgatcg aggaacggct     4260

gaaaacctat gcccacctgt tcgacgacaa agtgatgaag cagctgaagc ggcggagata     4320

caccggctgg ggcaggctga gccggaagct gatcaacggc atccgggaca agcagtccgg     4380

caagacaatc ctggatttcc tgaagtccga cggcttcgcc aacagaaact tcatgcagct     4440

gatccacgac gacagcctga cctttaaaga ggacatccag aaagcccagg tgtccggcca     4500

gggcgatagc ctgcacgagc acattgccaa tctggccggc agccccgcca ttaagaaggg     4560

catcctgcag acagtgaagg tggtggacga gctcgtgaaa gtgatgggcc ggcacaagcc     4620

cgagaacatc gtgatcgaaa tggccagaga gaaccagacc acccagaagg gacagaagaa     4680

cagccgcgag agaatgaagc ggatcgaaga gggcatcaaa gagctgggca gccagatcct     4740

gaaagaacac cccgtggaaa acacccagct gcagaacgag aagctgtacc tgtactacct     4800

gcagaatggg cgggatatgt acgtggacca ggaactggac atcaaccggc tgtccgacta     4860

cgatgtggac cacatcgtgc ctcagagctt tctgaaggac gactccatcg acaacaaggt     4920

gctgaccaga agcgacaagg cccggggcaa gagcgacaac gtgccctccg aagaggtcgt     4980

gaagaagatg aagaactact ggcggcagct gctgaacgcc aagctgatta cccagagaaa     5040

gttcgacaat ctgaccaagg ccgagagagg cggcctgagc gaactggata aggccggctt     5100

catcaagaga cagctggtgg aaacccggca gatcacaaag cacgtggcac agatcctgga     5160

ctcccggatg aacactaagt acgacgagaa tgacaagctg atccgggaag tgaaagtgat     5220

caccctgaag tccaagctgg tgtccgattt ccggaaggat ttccagtttt acaaagtgcg     5280

cgagatcaac aactaccacc acgcccacga cgcctacctg aacgccgtcg tgggaaccgc     5340

cctgatcaaa aagtacccta agctggaaag cgagttcgtg tacggcgact acaaggtgta     5400

cgacgtgcgg aagatgatcg ccaagagcga gcaggaaatc ggcaaggcta ccgccaagta     5460

cttcttctac agcaacatca tgaacttttt caagaccgag attaccctgg ccaacggcga     5520

gatccggaag cggcctctga tcgagacaaa cggcgaaacc ggggagatcg tgtgggataa     5580

gggccgggat tttgccaccg tgcggaaagt gctgagcatg ccccaagtga atatcgtgaa     5640

aaagaccgag gtgcagacag gcggcttcag caaagagtct atcctgccca agaggaacag     5700

cgataagctg atcgccagaa agaaggactg ggaccctaag aagtacggcg gcttcgacag     5760

ccccaccgtg gcctattctg tgctggtggt ggccaaagtg gaaaagggca agtccaagaa     5820

actgaagagt gtgaaagagc tgctggggat caccatcatg gaaagaagca gcttcgagaa     5880

gaatcccatc gactttctgg aagccaaggg ctacaaagaa gtgaaaaagg acctgatcat     5940

caagctgcct aagtactccc tgttcgagct ggaaaacggc cggaagagaa tgctggcctc     6000

tgccggcgaa ctgcagaagg gaaacgaact ggccctgccc tccaaatatg tgaacttcct     6060

gtacctggcc agccactatg agaagctgaa gggctccccc gaggataatg agcagaaaca     6120

gctgtttgtg gaacagcaca agcactacct ggacgagatc atcgagcaga tcagcgagtt     6180

ctccaagaga gtgatcctgg ccgacgctaa tctggacaaa gtgctgtccg cctacaacaa     6240

gcaccgggat aagcccatca gagagcaggc cgagaatatc atccacctgt ttaccctgac     6300

caatctggga gcccctgccg ccttcaagta ctttgacacc accatcgacc ggaagaggta     6360

caccagcacc aaagaggtgc tggacgccac cctgatccac cagagcatca ccggcctgta     6420

cgagacacgg atcgacctgt ctcagctggg aggcgacagc gctggaggag gtggaagcgg     6480

aggaggagga agcggaggag gaggtagcgg acctaagaaa aagaggaagg tggcggccgc     6540

tggatccgga cgggctgacg cattggacga ttttgatctg gatatgctgg gaagtgacgc     6600

cctcgatgat tttgaccttg acatgcttgg ttcggatgcc cttgatgact ttgacctcga     6660

catgctcggc agtgacgccc ttgatgattt cgacctggac atgctgatta actgtacagg     6720

cagtggagag ggcagaggaa gtctgctaac atgcggtgac gtcgaggaga atcctggccc     6780

aatggcttca aactttactc agttcgtgct cgtggacaat ggtgggacag gggatgtgac     6840

agtggctcct tctaatttcg ctaatggggt ggcagagtgg atcagctcca actcacggag     6900

ccaggcctac aaggtgacat gcagcgtcag gcagtctagt gcccagaaga gaaagtatac     6960

catcaaggtg gaggtcccca aagtggctac ccagacagtg ggcggagtcg aactgcctgt     7020

cgccgcttgg aggtcctacc tgaacatgga gctcactatc ccaattttcg ctaccaattc     7080

tgactgtgaa ctcatcgtga aggcaatgca ggggctcctc aaagacggta atcctatccc     7140

ttccgccatc gccgctaact caggtatcta cagcgctgga ggaggtggaa gcggaggagg     7200

aggaagcgga ggaggaggta gcggacctaa gaaaaagagg aaggtggcgg ccgctggatc     7260

cccttcaggg cagatcagca accaggccct ggctctggcc cctagctccg ctccagtgct     7320

ggcccagact atggtgccct ctagtgctat ggtgcctctg gcccagccac ctgctccagc     7380

ccctgtgctg accccaggac caccccagtc actgagcgct ccagtgccca agtctacaca     7440

ggccggcgag gggactctga gtgaagctct gctgcacctg cagttcgacg ctgatgagga     7500

cctgggagct ctgctgggga acagcaccga tcccggagtg ttcacagatc tggcctccgt     7560

ggacaactct gagtttcagc agctgctgaa tcagggcgtg tccatgtctc atagtacagc     7620

cgaaccaatg ctgatggagt accccgaagc cattacccgg ctggtgaccg gcagccagcg     7680

gccccccgac cccgctccaa ctcccctggg aaccagcggc ctgcctaatg ggctgtccgg     7740

agatgaagac ttctcaagca tcgctgatat ggactttagt gccctgctgt cacagatttc     7800

ctctagtggg cagggaggag gtggaagcgg cttcagcgtg gacaccagtg ccctgctgga     7860

cctgttcagc ccctcggtga ccgtgcccga catgagcctg cctgaccttg acagcagcct     7920

ggccagtatc caagagctcc tgtctcccca ggagcccccc aggcctcccg aggcagagaa     7980

cagcagcccg gattcaggga agcagctggt gcactacaca gcgcagccgc tgttcctgct     8040

ggaccccggc tccgtggaca ccgggagcaa cgacctgccg gtgctgtttg agctgggaga     8100

gggctcctac ttctccgaag gggacggctt cgccgaggac cccaccatct ccctgctgac     8160

aggctcggag cctcccaaag ccaaggaccc cactgtctcc tgagaattcg atatcaagct     8220

tatcgataat caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta     8280

tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc     8340

ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga     8400

ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac     8460

ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc     8520

cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc     8580

tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt cctttccttg     8640

gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc     8700

ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc     8760

gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcatcg     8820

ataccgtcga cctcgacctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc     8880

tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat     8940

gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg     9000

caggacagca agggggagga ttgggaagac aatggcaggc atg                       9043


<210> 60
<211> 5895
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 60
atgaaaaggc cggcggccac gaaaaaggcc ggccaggcaa aaaagaaaaa ggacaagaag       60

tacagcatcg gcctggccat cggcaccaac tctgtgggct gggccgtgat caccgacgag      120

tacaaggtgc ccagcaagaa attcaaggtg ctgggcaaca ccgaccggca cagcatcaag      180

aagaacctga tcggagccct gctgttcgac agcggcgaaa cagccgaggc cacccggctg      240

aagagaaccg ccagaagaag atacaccaga cggaagaacc ggatctgcta tctgcaagag      300

atcttcagca acgagatggc caaggtggac gacagcttct tccacagact ggaagagtcc      360

ttcctggtgg aagaggataa gaagcacgag cggcacccca tcttcggcaa catcgtggac      420

gaggtggcct accacgagaa gtaccccacc atctaccacc tgagaaagaa actggtggac      480

agcaccgaca aggccgacct gcggctgatc tatctggccc tggcccacat gatcaagttc      540

cggggccact tcctgatcga gggcgacctg aaccccgaca acagcgacgt ggacaagctg      600

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg aaaaccccat caacgccagc      660

ggcgtggacg ccaaggccat cctgtctgcc agactgagca agagcagacg gctggaaaat      720

ctgatcgccc agctgcccgg cgagaagaag aatggcctgt tcggcaacct gattgccctg      780

agcctgggcc tgacccccaa cttcaagagc aacttcgacc tggccgagga tgccaaactg      840

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac      900

cagtacgccg acctgtttct ggccgccaag aacctgtccg acgccatcct gctgagcgac      960

atcctgagag tgaacaccga gatcaccaag gcccccctga gcgcctctat gatcaagaga     1020

tacgacgagc accaccagga cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct     1080

gagaagtaca aagagatttt cttcgaccag agcaagaacg gctacgccgg ctacattgac     1140

ggcggagcca gccaggaaga gttctacaag ttcatcaagc ccatcctgga aaagatggac     1200

ggcaccgagg aactgctcgt gaagctgaac agagaggacc tgctgcggaa gcagcggacc     1260

ttcgacaacg gcagcatccc ccaccagatc cacctgggag agctgcacgc cattctgcgg     1320

cggcaggaag atttttaccc attcctgaag gacaaccggg aaaagatcga gaagatcctg     1380

accttccgca tcccctacta cgtgggccct ctggccaggg gaaacagcag attcgcctgg     1440

atgaccagaa agagcgagga aaccatcacc ccctggaact tcgaggaagt ggtggacaag     1500

ggcgcttccg cccagagctt catcgagcgg atgaccaact tcgataagaa cctgcccaac     1560

gagaaggtgc tgcccaagca cagcctgctg tacgagtact tcaccgtgta taacgagctg     1620

accaaagtga aatacgtgac cgagggaatg agaaagcccg ccttcctgag cggcgagcag     1680

aaaaaggcca tcgtggacct gctgttcaag accaaccgga aagtgaccgt gaagcagctg     1740

aaagaggact acttcaagaa aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa     1800

gatcggttca acgcctccct gggcacatac cacgatctgc tgaaaattat caaggacaag     1860

gacttcctgg acaatgagga aaacgaggac attctggaag atatcgtgct gaccctgaca     1920

ctgtttgagg acagagagat gatcgaggaa cggctgaaaa cctatgccca cctgttcgac     1980

gacaaagtga tgaagcagct gaagcggcgg agatacaccg gctggggcag gctgagccgg     2040

aagctgatca acggcatccg ggacaagcag tccggcaaga caatcctgga tttcctgaag     2100

tccgacggct tcgccaacag aaacttcatg cagctgatcc acgacgacag cctgaccttt     2160

aaagaggaca tccagaaagc ccaggtgtcc ggccagggcg atagcctgca cgagcacatt     2220

gccaatctgg ccggcagccc cgccattaag aagggcatcc tgcagacagt gaaggtggtg     2280

gacgagctcg tgaaagtgat gggccggcac aagcccgaga acatcgtgat cgaaatggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaat gaagcggatc     2400

gaagagggca tcaaagagct gggcagccag atcctgaaag aacaccccgt ggaaaacacc     2460

cagctgcaga acgagaagct gtacctgtac tacctgcaga atgggcggga tatgtacgtg     2520

gaccaggaac tggacatcaa ccggctgtcc gactacgatg tggaccacat cgtgcctcag     2580

agctttctga aggacgactc catcgacaac aaggtgctga ccagaagcga caaggcccgg     2640

ggcaagagcg acaacgtgcc ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg     2700

cagctgctga acgccaagct gattacccag agaaagttcg acaatctgac caaggccgag     2760

agaggcggcc tgagcgaact ggataaggcc ggcttcatca agagacagct ggtggaaacc     2820

cggcagatca caaagcacgt ggcacagatc ctggactccc ggatgaacac taagtacgac     2880

gagaatgaca agctgatccg ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc     2940

gatttccgga aggatttcca gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc     3000

cacgacgcct acctgaacgc cgtcgtggga accgccctga tcaaaaagta ccctaagctg     3060

gaaagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgcggaagat gatcgccaag     3120

agcgagcagg aaatcggcaa ggctaccgcc aagtacttct tctacagcaa catcatgaac     3180

tttttcaaga ccgagattac cctggccaac ggcgagatcc ggaagcggcc tctgatcgag     3240

acaaacggcg aaaccgggga gatcgtgtgg gataagggcc gggattttgc caccgtgcgg     3300

aaagtgctga gcatgcccca agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc     3360

ttcagcaaag agtctatcct gcccaagagg aacagcgata agctgatcgc cagaaagaag     3420

gactgggacc ctaagaagta cggcggcttc gacagcccca ccgtggccta ttctgtgctg     3480

gtggtggcca aagtggaaaa gggcaagtcc aagaaactga agagtgtgaa agagctgctg     3540

gggatcacca tcatggaaag aagcagcttc gagaagaatc ccatcgactt tctggaagcc     3600

aagggctaca aagaagtgaa aaaggacctg atcatcaagc tgcctaagta ctccctgttc     3660

gagctggaaa acggccggaa gagaatgctg gcctctgccg gcgaactgca gaagggaaac     3720

gaactggccc tgccctccaa atatgtgaac ttcctgtacc tggccagcca ctatgagaag     3780

ctgaagggct cccccgagga taatgagcag aaacagctgt ttgtggaaca gcacaagcac     3840

tacctggacg agatcatcga gcagatcagc gagttctcca agagagtgat cctggccgac     3900

gctaatctgg acaaagtgct gtccgcctac aacaagcacc gggataagcc catcagagag     3960

caggccgaga atatcatcca cctgtttacc ctgaccaatc tgggagcccc tgccgccttc     4020

aagtactttg acaccaccat cgaccggaag aggtacacca gcaccaaaga ggtgctggac     4080

gccaccctga tccaccagag catcaccggc ctgtacgaga cacggatcga cctgtctcag     4140

ctgggaggcg acagcgctgg aggaggtgga agcggaggag gaggaagcgg aggaggaggt     4200

agcggaccta agaaaaagag gaaggtggcg gccgctggat ccggacgggc tgacgcattg     4260

gacgattttg atctggatat gctgggaagt gacgccctcg atgattttga ccttgacatg     4320

cttggttcgg atgcccttga tgactttgac ctcgacatgc tcggcagtga cgcccttgat     4380

gatttcgacc tggacatgct gattaactgt acaggcagtg gagagggcag aggaagtctg     4440

ctaacatgcg gtgacgtcga ggagaatcct ggcccaatgg cttcaaactt tactcagttc     4500

gtgctcgtgg acaatggtgg gacaggggat gtgacagtgg ctccttctaa tttcgctaat     4560

ggggtggcag agtggatcag ctccaactca cggagccagg cctacaaggt gacatgcagc     4620

gtcaggcagt ctagtgccca gaagagaaag tataccatca aggtggaggt ccccaaagtg     4680

gctacccaga cagtgggcgg agtcgaactg cctgtcgccg cttggaggtc ctacctgaac     4740

atggagctca ctatcccaat tttcgctacc aattctgact gtgaactcat cgtgaaggca     4800

atgcaggggc tcctcaaaga cggtaatcct atcccttccg ccatcgccgc taactcaggt     4860

atctacagcg ctggaggagg tggaagcgga ggaggaggaa gcggaggagg aggtagcgga     4920

cctaagaaaa agaggaaggt ggcggccgct ggatcccctt cagggcagat cagcaaccag     4980

gccctggctc tggcccctag ctccgctcca gtgctggccc agactatggt gccctctagt     5040

gctatggtgc ctctggccca gccacctgct ccagcccctg tgctgacccc aggaccaccc     5100

cagtcactga gcgctccagt gcccaagtct acacaggccg gcgaggggac tctgagtgaa     5160

gctctgctgc acctgcagtt cgacgctgat gaggacctgg gagctctgct ggggaacagc     5220

accgatcccg gagtgttcac agatctggcc tccgtggaca actctgagtt tcagcagctg     5280

ctgaatcagg gcgtgtccat gtctcatagt acagccgaac caatgctgat ggagtacccc     5340

gaagccatta cccggctggt gaccggcagc cagcggcccc ccgaccccgc tccaactccc     5400

ctgggaacca gcggcctgcc taatgggctg tccggagatg aagacttctc aagcatcgct     5460

gatatggact ttagtgccct gctgtcacag atttcctcta gtgggcaggg aggaggtgga     5520

agcggcttca gcgtggacac cagtgccctg ctggacctgt tcagcccctc ggtgaccgtg     5580

cccgacatga gcctgcctga ccttgacagc agcctggcca gtatccaaga gctcctgtct     5640

ccccaggagc cccccaggcc tcccgaggca gagaacagca gcccggattc agggaagcag     5700

ctggtgcact acacagcgca gccgctgttc ctgctggacc ccggctccgt ggacaccggg     5760

agcaacgacc tgccggtgct gtttgagctg ggagagggct cctacttctc cgaaggggac     5820

ggcttcgccg aggaccccac catctccctg ctgacaggct cggagcctcc caaagccaag     5880

gaccccactg tctcc                                                      5895


<210> 61
<211> 1965
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 61
Met Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys 
1               5                   10                  15      


Lys Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Ala Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Ser  Ala Gly Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly 
    1385                 1390                 1395             


Gly Gly  Ser Gly Pro Lys Lys  Lys Arg Lys Val Ala  Ala Ala Gly 
    1400                 1405                 1410             


Ser Gly  Arg Ala Asp Ala Leu  Asp Asp Phe Asp Leu  Asp Met Leu 
    1415                 1420                 1425             


Gly Ser  Asp Ala Leu Asp Asp  Phe Asp Leu Asp Met  Leu Gly Ser 
    1430                 1435                 1440             


Asp Ala  Leu Asp Asp Phe Asp  Leu Asp Met Leu Gly  Ser Asp Ala 
    1445                 1450                 1455             


Leu Asp  Asp Phe Asp Leu Asp  Met Leu Ile Asn Cys  Thr Gly Ser 
    1460                 1465                 1470             


Gly Glu  Gly Arg Gly Ser Leu  Leu Thr Cys Gly Asp  Val Glu Glu 
    1475                 1480                 1485             


Asn Pro  Gly Pro Met Ala Ser  Asn Phe Thr Gln Phe  Val Leu Val 
    1490                 1495                 1500             


Asp Asn  Gly Gly Thr Gly Asp  Val Thr Val Ala Pro  Ser Asn Phe 
    1505                 1510                 1515             


Ala Asn  Gly Val Ala Glu Trp  Ile Ser Ser Asn Ser  Arg Ser Gln 
    1520                 1525                 1530             


Ala Tyr  Lys Val Thr Cys Ser  Val Arg Gln Ser Ser  Ala Gln Lys 
    1535                 1540                 1545             


Arg Lys  Tyr Thr Ile Lys Val  Glu Val Pro Lys Val  Ala Thr Gln 
    1550                 1555                 1560             


Thr Val  Gly Gly Val Glu Leu  Pro Val Ala Ala Trp  Arg Ser Tyr 
    1565                 1570                 1575             


Leu Asn  Met Glu Leu Thr Ile  Pro Ile Phe Ala Thr  Asn Ser Asp 
    1580                 1585                 1590             


Cys Glu  Leu Ile Val Lys Ala  Met Gln Gly Leu Leu  Lys Asp Gly 
    1595                 1600                 1605             


Asn Pro  Ile Pro Ser Ala Ile  Ala Ala Asn Ser Gly  Ile Tyr Ser 
    1610                 1615                 1620             


Ala Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1625                 1630                 1635             


Ser Gly  Pro Lys Lys Lys Arg  Lys Val Ala Ala Ala  Gly Ser Pro 
    1640                 1645                 1650             


Ser Gly  Gln Ile Ser Asn Gln  Ala Leu Ala Leu Ala  Pro Ser Ser 
    1655                 1660                 1665             


Ala Pro  Val Leu Ala Gln Thr  Met Val Pro Ser Ser  Ala Met Val 
    1670                 1675                 1680             


Pro Leu  Ala Gln Pro Pro Ala  Pro Ala Pro Val Leu  Thr Pro Gly 
    1685                 1690                 1695             


Pro Pro  Gln Ser Leu Ser Ala  Pro Val Pro Lys Ser  Thr Gln Ala 
    1700                 1705                 1710             


Gly Glu  Gly Thr Leu Ser Glu  Ala Leu Leu His Leu  Gln Phe Asp 
    1715                 1720                 1725             


Ala Asp  Glu Asp Leu Gly Ala  Leu Leu Gly Asn Ser  Thr Asp Pro 
    1730                 1735                 1740             


Gly Val  Phe Thr Asp Leu Ala  Ser Val Asp Asn Ser  Glu Phe Gln 
    1745                 1750                 1755             


Gln Leu  Leu Asn Gln Gly Val  Ser Met Ser His Ser  Thr Ala Glu 
    1760                 1765                 1770             


Pro Met  Leu Met Glu Tyr Pro  Glu Ala Ile Thr Arg  Leu Val Thr 
    1775                 1780                 1785             


Gly Ser  Gln Arg Pro Pro Asp  Pro Ala Pro Thr Pro  Leu Gly Thr 
    1790                 1795                 1800             


Ser Gly  Leu Pro Asn Gly Leu  Ser Gly Asp Glu Asp  Phe Ser Ser 
    1805                 1810                 1815             


Ile Ala  Asp Met Asp Phe Ser  Ala Leu Leu Ser Gln  Ile Ser Ser 
    1820                 1825                 1830             


Ser Gly  Gln Gly Gly Gly Gly  Ser Gly Phe Ser Val  Asp Thr Ser 
    1835                 1840                 1845             


Ala Leu  Leu Asp Leu Phe Ser  Pro Ser Val Thr Val  Pro Asp Met 
    1850                 1855                 1860             


Ser Leu  Pro Asp Leu Asp Ser  Ser Leu Ala Ser Ile  Gln Glu Leu 
    1865                 1870                 1875             


Leu Ser  Pro Gln Glu Pro Pro  Arg Pro Pro Glu Ala  Glu Asn Ser 
    1880                 1885                 1890             


Ser Pro  Asp Ser Gly Lys Gln  Leu Val His Tyr Thr  Ala Gln Pro 
    1895                 1900                 1905             


Leu Phe  Leu Leu Asp Pro Gly  Ser Val Asp Thr Gly  Ser Asn Asp 
    1910                 1915                 1920             


Leu Pro  Val Leu Phe Glu Leu  Gly Glu Gly Ser Tyr  Phe Ser Glu 
    1925                 1930                 1935             


Gly Asp  Gly Phe Ala Glu Asp  Pro Thr Ile Ser Leu  Leu Thr Gly 
    1940                 1945                 1950             


Ser Glu  Pro Pro Lys Ala Lys  Asp Pro Thr Val Ser  
    1955                 1960                 1965 


<210> 62
<211> 5895
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 62
augaaaaggc cggcggccac gaaaaaggcc ggccaggcaa aaaagaaaaa ggacaagaag       60

uacagcaucg gccuggccau cggcaccaac ucugugggcu gggccgugau caccgacgag      120

uacaaggugc ccagcaagaa auucaaggug cugggcaaca ccgaccggca cagcaucaag      180

aagaaccuga ucggagcccu gcuguucgac agcggcgaaa cagccgaggc cacccggcug      240

aagagaaccg ccagaagaag auacaccaga cggaagaacc ggaucugcua ucugcaagag      300

aucuucagca acgagauggc caagguggac gacagcuucu uccacagacu ggaagagucc      360

uuccuggugg aagaggauaa gaagcacgag cggcacccca ucuucggcaa caucguggac      420

gagguggccu accacgagaa guaccccacc aucuaccacc ugagaaagaa acugguggac      480

agcaccgaca aggccgaccu gcggcugauc uaucuggccc uggcccacau gaucaaguuc      540

cggggccacu uccugaucga gggcgaccug aaccccgaca acagcgacgu ggacaagcug      600

uucauccagc uggugcagac cuacaaccag cuguucgagg aaaaccccau caacgccagc      660

ggcguggacg ccaaggccau ccugucugcc agacugagca agagcagacg gcuggaaaau      720

cugaucgccc agcugcccgg cgagaagaag aauggccugu ucggcaaccu gauugcccug      780

agccugggcc ugacccccaa cuucaagagc aacuucgacc uggccgagga ugccaaacug      840

cagcugagca aggacaccua cgacgacgac cuggacaacc ugcuggccca gaucggcgac      900

caguacgccg accuguuucu ggccgccaag aaccuguccg acgccauccu gcugagcgac      960

auccugagag ugaacaccga gaucaccaag gccccccuga gcgccucuau gaucaagaga     1020

uacgacgagc accaccagga ccugacccug cugaaagcuc ucgugcggca gcagcugccu     1080

gagaaguaca aagagauuuu cuucgaccag agcaagaacg gcuacgccgg cuacauugac     1140

ggcggagcca gccaggaaga guucuacaag uucaucaagc ccauccugga aaagauggac     1200

ggcaccgagg aacugcucgu gaagcugaac agagaggacc ugcugcggaa gcagcggacc     1260

uucgacaacg gcagcauccc ccaccagauc caccugggag agcugcacgc cauucugcgg     1320

cggcaggaag auuuuuaccc auuccugaag gacaaccggg aaaagaucga gaagauccug     1380

accuuccgca uccccuacua cgugggcccu cuggccaggg gaaacagcag auucgccugg     1440

augaccagaa agagcgagga aaccaucacc cccuggaacu ucgaggaagu gguggacaag     1500

ggcgcuuccg cccagagcuu caucgagcgg augaccaacu ucgauaagaa ccugcccaac     1560

gagaaggugc ugcccaagca cagccugcug uacgaguacu ucaccgugua uaacgagcug     1620

accaaaguga aauacgugac cgagggaaug agaaagcccg ccuuccugag cggcgagcag     1680

aaaaaggcca ucguggaccu gcuguucaag accaaccgga aagugaccgu gaagcagcug     1740

aaagaggacu acuucaagaa aaucgagugc uucgacuccg uggaaaucuc cggcguggaa     1800

gaucgguuca acgccucccu gggcacauac cacgaucugc ugaaaauuau caaggacaag     1860

gacuuccugg acaaugagga aaacgaggac auucuggaag auaucgugcu gacccugaca     1920

cuguuugagg acagagagau gaucgaggaa cggcugaaaa ccuaugccca ccuguucgac     1980

gacaaaguga ugaagcagcu gaagcggcgg agauacaccg gcuggggcag gcugagccgg     2040

aagcugauca acggcauccg ggacaagcag uccggcaaga caauccugga uuuccugaag     2100

uccgacggcu ucgccaacag aaacuucaug cagcugaucc acgacgacag ccugaccuuu     2160

aaagaggaca uccagaaagc ccaggugucc ggccagggcg auagccugca cgagcacauu     2220

gccaaucugg ccggcagccc cgccauuaag aagggcaucc ugcagacagu gaagguggug     2280

gacgagcucg ugaaagugau gggccggcac aagcccgaga acaucgugau cgaaauggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaau gaagcggauc     2400

gaagagggca ucaaagagcu gggcagccag auccugaaag aacaccccgu ggaaaacacc     2460

cagcugcaga acgagaagcu guaccuguac uaccugcaga augggcggga uauguacgug     2520

gaccaggaac uggacaucaa ccggcugucc gacuacgaug uggaccacau cgugccucag     2580

agcuuucuga aggacgacuc caucgacaac aaggugcuga ccagaagcga caaggcccgg     2640

ggcaagagcg acaacgugcc cuccgaagag gucgugaaga agaugaagaa cuacuggcgg     2700

cagcugcuga acgccaagcu gauuacccag agaaaguucg acaaucugac caaggccgag     2760

agaggcggcc ugagcgaacu ggauaaggcc ggcuucauca agagacagcu gguggaaacc     2820

cggcagauca caaagcacgu ggcacagauc cuggacuccc ggaugaacac uaaguacgac     2880

gagaaugaca agcugauccg ggaagugaaa gugaucaccc ugaaguccaa gcuggugucc     2940

gauuuccgga aggauuucca guuuuacaaa gugcgcgaga ucaacaacua ccaccacgcc     3000

cacgacgccu accugaacgc cgucguggga accgcccuga ucaaaaagua cccuaagcug     3060

gaaagcgagu ucguguacgg cgacuacaag guguacgacg ugcggaagau gaucgccaag     3120

agcgagcagg aaaucggcaa ggcuaccgcc aaguacuucu ucuacagcaa caucaugaac     3180

uuuuucaaga ccgagauuac ccuggccaac ggcgagaucc ggaagcggcc ucugaucgag     3240

acaaacggcg aaaccgggga gaucgugugg gauaagggcc gggauuuugc caccgugcgg     3300

aaagugcuga gcaugcccca agugaauauc gugaaaaaga ccgaggugca gacaggcggc     3360

uucagcaaag agucuauccu gcccaagagg aacagcgaua agcugaucgc cagaaagaag     3420

gacugggacc cuaagaagua cggcggcuuc gacagcccca ccguggccua uucugugcug     3480

gugguggcca aaguggaaaa gggcaagucc aagaaacuga agagugugaa agagcugcug     3540

gggaucacca ucauggaaag aagcagcuuc gagaagaauc ccaucgacuu ucuggaagcc     3600

aagggcuaca aagaagugaa aaaggaccug aucaucaagc ugccuaagua cucccuguuc     3660

gagcuggaaa acggccggaa gagaaugcug gccucugccg gcgaacugca gaagggaaac     3720

gaacuggccc ugcccuccaa auaugugaac uuccuguacc uggccagcca cuaugagaag     3780

cugaagggcu cccccgagga uaaugagcag aaacagcugu uuguggaaca gcacaagcac     3840

uaccuggacg agaucaucga gcagaucagc gaguucucca agagagugau ccuggccgac     3900

gcuaaucugg acaaagugcu guccgccuac aacaagcacc gggauaagcc caucagagag     3960

caggccgaga auaucaucca ccuguuuacc cugaccaauc ugggagcccc ugccgccuuc     4020

aaguacuuug acaccaccau cgaccggaag agguacacca gcaccaaaga ggugcuggac     4080

gccacccuga uccaccagag caucaccggc cuguacgaga cacggaucga ccugucucag     4140

cugggaggcg acagcgcugg aggaggugga agcggaggag gaggaagcgg aggaggaggu     4200

agcggaccua agaaaaagag gaagguggcg gccgcuggau ccggacgggc ugacgcauug     4260

gacgauuuug aucuggauau gcugggaagu gacgcccucg augauuuuga ccuugacaug     4320

cuugguucgg augcccuuga ugacuuugac cucgacaugc ucggcaguga cgcccuugau     4380

gauuucgacc uggacaugcu gauuaacugu acaggcagug gagagggcag aggaagucug     4440

cuaacaugcg gugacgucga ggagaauccu ggcccaaugg cuucaaacuu uacucaguuc     4500

gugcucgugg acaauggugg gacaggggau gugacagugg cuccuucuaa uuucgcuaau     4560

gggguggcag aguggaucag cuccaacuca cggagccagg ccuacaaggu gacaugcagc     4620

gucaggcagu cuagugccca gaagagaaag uauaccauca agguggaggu ccccaaagug     4680

gcuacccaga cagugggcgg agucgaacug ccugucgccg cuuggagguc cuaccugaac     4740

auggagcuca cuaucccaau uuucgcuacc aauucugacu gugaacucau cgugaaggca     4800

augcaggggc uccucaaaga cgguaauccu aucccuuccg ccaucgccgc uaacucaggu     4860

aucuacagcg cuggaggagg uggaagcgga ggaggaggaa gcggaggagg agguagcgga     4920

ccuaagaaaa agaggaaggu ggcggccgcu ggauccccuu cagggcagau cagcaaccag     4980

gcccuggcuc uggccccuag cuccgcucca gugcuggccc agacuauggu gcccucuagu     5040

gcuauggugc cucuggccca gccaccugcu ccagccccug ugcugacccc aggaccaccc     5100

cagucacuga gcgcuccagu gcccaagucu acacaggccg gcgaggggac ucugagugaa     5160

gcucugcugc accugcaguu cgacgcugau gaggaccugg gagcucugcu ggggaacagc     5220

accgaucccg gaguguucac agaucuggcc uccguggaca acucugaguu ucagcagcug     5280

cugaaucagg gcguguccau gucucauagu acagccgaac caaugcugau ggaguacccc     5340

gaagccauua cccggcuggu gaccggcagc cagcggcccc ccgaccccgc uccaacuccc     5400

cugggaacca gcggccugcc uaaugggcug uccggagaug aagacuucuc aagcaucgcu     5460

gauauggacu uuagugcccu gcugucacag auuuccucua gugggcaggg aggaggugga     5520

agcggcuuca gcguggacac cagugcccug cuggaccugu ucagccccuc ggugaccgug     5580

cccgacauga gccugccuga ccuugacagc agccuggcca guauccaaga gcuccugucu     5640

ccccaggagc cccccaggcc ucccgaggca gagaacagca gcccggauuc agggaagcag     5700

cuggugcacu acacagcgca gccgcuguuc cugcuggacc ccggcuccgu ggacaccggg     5760

agcaacgacc ugccggugcu guuugagcug ggagagggcu ccuacuucuc cgaaggggac     5820

ggcuucgccg aggaccccac caucucccug cugacaggcu cggagccucc caaagccaag     5880

gaccccacug ucucc                                                      5895


<210> 63
<211> 3812
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (1)..(32)
<223> /note="First rox site"

<220>
<221> misc_feature
<222> (111)..(710)
<223> /note="Sequence encoding puromycin-N-acetyltransferase for 
      resistance to puromycin family antibiotics"

<220>
<221> misc_feature
<222> (797)..(2338)
<223> /note="Polyadenylation signal"

<220>
<221> misc_feature
<222> (2363)..(2394)
<223> /note="Second rox site"

<220>
<221> misc_feature
<222> (2401)..(2640)
<223> /note="First U6 promoter"

<220>
<221> misc_feature
<222> (2641)..(2797)
<223> /note="First guide RNA coding sequence"

<220>
<221> misc_feature
<222> (2641)..(2660)
<223> /note="n is a, c, g, or t"

<220>
<221> misc_feature
<222> (2883)..(3122)
<223> /note="Second U6 promoter"

<220>
<221> misc_feature
<222> (3123)..(3279)
<223> /note="Second guide RNA coding sequence"

<220>
<221> misc_feature
<222> (3123)..(3142)
<223> /note="n is a, c, g, or t"

<220>
<221> misc_feature
<222> (3364)..(3603)
<223> /note="Third U6 promoter"

<220>
<221> misc_feature
<222> (3604)..(3760)
<223> /note="Third guide RNA coding sequence"

<220>
<221> misc_feature
<222> (3604)..(3623)
<223> /note="n is a, c, g, or t"

<400> 63
taactttaaa taatgccaat tatttaaagt tacctgcagg acgtgttgac aattaatcat       60

cggcatagta tatcggcata gtataatacg acaaggtgag gaactaaacc atgaccgagt      120

acaagcccac ggtgcgcctc gccacccgcg acgacgtccc cagggccgta cgcaccctcg      180

ccgccgcgtt cgccgactac cccgccacgc gccacaccgt cgatccggac cgccacatcg      240

agcgggtcac cgagctgcaa gaactcttcc tcacgcgcgt cgggctcgac atcggcaagg      300

tgtgggtcgc ggacgacggc gccgcggtgg cggtctggac cacgccggag agcgtcgaag      360

cgggggcggt gttcgccgag atcggcccgc gcatggccga gttgagcggt tcccggctgg      420

ccgcgcagca acagatggaa ggcctcctgg cgccgcaccg gcccaaggag cccgcgtggt      480

tcctggccac cgtcggcgtc tcgcccgacc accagggcaa gggtctgggc agcgccgtcg      540

tgctccccgg agtggaggcg gccgagcgcg ccggggtgcc cgccttcctg gagacctccg      600

cgccccgcaa cctccccttc tacgagcggc tcggcttcac cgtcaccgcc gacgtcgagg      660

tgcccgaagg accgcgcacc tggtgcatga cccgcaagcc cggtgcctga cgcccgcccc      720

acgacccgca gcgcccgacc gaaaggagcg cacgacccca tgcatcgatg atctagagct      780

cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc      840

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa      900

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac      960

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg     1020

gcataacttc gtataatgta tgctatacgg gggatccgct gtaagtctgc agaaattgat     1080

gatctattaa acaataaaga tgtccactaa aatggaagtt tttcctgtca tactttgtta     1140

agaagggtga gaacagagta cctacatttt gaatggaagg attggagcta cgggggtggg     1200

ggtggggtgg gattagataa atgcctgctc tttactgaag gctctttact attgctttat     1260

gataatgttt catagttgga tatcataatt taaacaagca aaaccaaatt aagggccagc     1320

tcattcctcc cactcatgat ctatagatct atagatctct cgtgggatca ttgtttttct     1380

cttgattccc actttgtggt tctaagtact gtggtttcca aatgtgtcag tttcatagcc     1440

tgaagaacga gatcagcagc ctctgttcca catacacttc attctcagta ttgttttgcc     1500

aagttctaat tccatcagac ctcgacctgc agccgacgct aggtcgtcag tcaaagtacg     1560

tacctcaggt gcaggctgcc tatcagaagg tggtggctgg tgtggccaat gccctggctc     1620

acaaatacca ctgagatctt tttccctctg ccaaaaatta tggggacatc atgaagcccc     1680

ttgagcatct gacttctggc taataaagga aatttatttt cattgcaata gtgtgttgga     1740

attttttgtg tctctcactc ggaaggacat atgggagggc aaatcattta aaacatcaga     1800

atgagtattt ggtttagagt ttggcaacat atgcccatat gctggctgcc atgaacaaag     1860

gttggctata aagaggtcat cagtatatga aacagccccc tgctgtccat tccttattcc     1920

atagaaaagc cttgacttga ggttagattt tttttatatt ttgttttgtg ttattttttt     1980

ctttaacatc cctaaaattt tccttagatg ttttactagc cagatttttc ctcctctcct     2040

gactactccc agtcatagct gtccctcttc tcttatggag atccctcgag gacatgaggt     2100

cgtcgctgta atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc     2160

acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat     2220

tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt     2280

tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtcga     2340

cactgggtcg tgatcgggta cctaacttta aataatgcca attatttaaa gttagctagc     2400

tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga     2460

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa     2520

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc     2580

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc     2640

nnnnnnnnnn nnnnnnnnnn gttttagagc taggccaaca tgaggatcac ccatgtctgc     2700

agggcctagc aagttaaaat aaggctagtc cgttatcaac ttggccaaca tgaggatcac     2760

ccatgtctgc agggccaagt ggcaccgagt cggtgctttt tttgttttag agctagaaat     2820

agcaagttaa aataaggcta gtccgttttg agctccataa gactcggcct tagaacaagc     2880

tttttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataattg     2940

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     3000

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     3060

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     3120

ccnnnnnnnn nnnnnnnnnn nngttttaga gctaggccaa catgaggatc acccatgtct     3180

gcagggccta gcaagttaaa ataaggctag tccgttatca acttggccaa catgaggatc     3240

acccatgtct gcagggccaa gtggcaccga gtcggtgctt tttttgtttt agagctagaa     3300

atagcaagtt aaaataaggc tagtccgttt tatgcatgtg gctcccattt atacctggcc     3360

ggctttccca tgattccttc atatttgcat atacgataca aggctgttag agagataatt     3420

ggaattaatt tgactgtaaa cacaaagata ttagtacaaa atacgtgacg tagaaagtaa     3480

taatttcttg ggtagtttgc agttttaaaa ttatgtttta aaatggacta tcatatgctt     3540

accgtaactt gaaagtattt cgatttcttg gctttatata tcttgtggaa aggacgaaac     3600

accnnnnnnn nnnnnnnnnn nnngttttag agctaggcca acatgaggat cacccatgtc     3660

tgcagggcct agcaagttaa aataaggcta gtccgttatc aacttggcca acatgaggat     3720

cacccatgtc tgcagggcca agtggcaccg agtcggtgct ttttttgttt tagagctaga     3780

aatagcaagt taaaataagg ctagtccgtt tt                                   3812


<210> 64
<211> 1412
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> modified_base
<222> (241)..(260)
<223> a, c, g, or t

<220>
<221> modified_base
<222> (723)..(742)
<223> a, c, g, or t

<220>
<221> modified_base
<222> (1204)..(1223)
<223> a, c, g, or t

<400> 64
tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga       60

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa      120

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc      180

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc      240

nnnnnnnnnn nnnnnnnnnn gttttagagc taggccaaca tgaggatcac ccatgtctgc      300

agggcctagc aagttaaaat aaggctagtc cgttatcaac ttggccaaca tgaggatcac      360

ccatgtctgc agggccaagt ggcaccgagt cggtgctttt tttgttttag agctagaaat      420

agcaagttaa aataaggcta gtccgttttg agctccataa gactcggcct tagaacaagc      480

tttttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataattg      540

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat      600

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta      660

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca      720

ccnnnnnnnn nnnnnnnnnn nngttttaga gctaggccaa catgaggatc acccatgtct      780

gcagggccta gcaagttaaa ataaggctag tccgttatca acttggccaa catgaggatc      840

acccatgtct gcagggccaa gtggcaccga gtcggtgctt tttttgtttt agagctagaa      900

atagcaagtt aaaataaggc tagtccgttt tatgcatgtg gctcccattt atacctggcc      960

ggctttccca tgattccttc atatttgcat atacgataca aggctgttag agagataatt     1020

ggaattaatt tgactgtaaa cacaaagata ttagtacaaa atacgtgacg tagaaagtaa     1080

taatttcttg ggtagtttgc agttttaaaa ttatgtttta aaatggacta tcatatgctt     1140

accgtaactt gaaagtattt cgatttcttg gctttatata tcttgtggaa aggacgaaac     1200

accnnnnnnn nnnnnnnnnn nnngttttag agctaggcca acatgaggat cacccatgtc     1260

tgcagggcct agcaagttaa aataaggcta gtccgttatc aacttggcca acatgaggat     1320

cacccatgtc tgcagggcca agtggcaccg agtcggtgct ttttttgttt tagagctaga     1380

aatagcaagt taaaataagg ctagtccgtt tt                                   1412


<210> 65
<211> 3814
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (1)..(32)
<223> /note="First rox site"

<220>
<221> misc_feature
<222> (111)..(710)
<223> /note="Sequence encoding puromycin-N-acetyltransferase for 
      resistance to puromycin family antibiotics"

<220>
<221> misc_feature
<222> (797)..(2338)
<223> /note="Polyadenylation signal"

<220>
<221> misc_feature
<222> (2363)..(2394)
<223> /note="Second rox site"

<220>
<221> misc_feature
<222> (2401)..(2640)
<223> /note="First U6 promoter"

<220>
<221> misc_feature
<222> (2642)..(2798)
<223> /note="First Ttr guide RNA coding sequence"

<220>
<221> misc_feature
<222> (2884)..(3123)
<223> /note="Second U6 promoter"

<220>
<221> misc_feature
<222> (3125)..(3281)
<223> /note="Second Ttr guide RNA coding sequence"

<220>
<221> misc_feature
<222> (3366)..(3605)
<223> /note="Third U6 promoter"

<220>
<221> misc_feature
<222> (3606)..(3762)
<223> /note="Third Ttr guide RNA coding sequence"

<400> 65
taactttaaa taatgccaat tatttaaagt tacctgcagg acgtgttgac aattaatcat       60

cggcatagta tatcggcata gtataatacg acaaggtgag gaactaaacc atgaccgagt      120

acaagcccac ggtgcgcctc gccacccgcg acgacgtccc cagggccgta cgcaccctcg      180

ccgccgcgtt cgccgactac cccgccacgc gccacaccgt cgatccggac cgccacatcg      240

agcgggtcac cgagctgcaa gaactcttcc tcacgcgcgt cgggctcgac atcggcaagg      300

tgtgggtcgc ggacgacggc gccgcggtgg cggtctggac cacgccggag agcgtcgaag      360

cgggggcggt gttcgccgag atcggcccgc gcatggccga gttgagcggt tcccggctgg      420

ccgcgcagca acagatggaa ggcctcctgg cgccgcaccg gcccaaggag cccgcgtggt      480

tcctggccac cgtcggcgtc tcgcccgacc accagggcaa gggtctgggc agcgccgtcg      540

tgctccccgg agtggaggcg gccgagcgcg ccggggtgcc cgccttcctg gagacctccg      600

cgccccgcaa cctccccttc tacgagcggc tcggcttcac cgtcaccgcc gacgtcgagg      660

tgcccgaagg accgcgcacc tggtgcatga cccgcaagcc cggtgcctga cgcccgcccc      720

acgacccgca gcgcccgacc gaaaggagcg cacgacccca tgcatcgatg atctagagct      780

cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc      840

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa      900

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac      960

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg     1020

gcataacttc gtataatgta tgctatacgg gggatccgct gtaagtctgc agaaattgat     1080

gatctattaa acaataaaga tgtccactaa aatggaagtt tttcctgtca tactttgtta     1140

agaagggtga gaacagagta cctacatttt gaatggaagg attggagcta cgggggtggg     1200

ggtggggtgg gattagataa atgcctgctc tttactgaag gctctttact attgctttat     1260

gataatgttt catagttgga tatcataatt taaacaagca aaaccaaatt aagggccagc     1320

tcattcctcc cactcatgat ctatagatct atagatctct cgtgggatca ttgtttttct     1380

cttgattccc actttgtggt tctaagtact gtggtttcca aatgtgtcag tttcatagcc     1440

tgaagaacga gatcagcagc ctctgttcca catacacttc attctcagta ttgttttgcc     1500

aagttctaat tccatcagac ctcgacctgc agccgacgct aggtcgtcag tcaaagtacg     1560

tacctcaggt gcaggctgcc tatcagaagg tggtggctgg tgtggccaat gccctggctc     1620

acaaatacca ctgagatctt tttccctctg ccaaaaatta tggggacatc atgaagcccc     1680

ttgagcatct gacttctggc taataaagga aatttatttt cattgcaata gtgtgttgga     1740

attttttgtg tctctcactc ggaaggacat atgggagggc aaatcattta aaacatcaga     1800

atgagtattt ggtttagagt ttggcaacat atgcccatat gctggctgcc atgaacaaag     1860

gttggctata aagaggtcat cagtatatga aacagccccc tgctgtccat tccttattcc     1920

atagaaaagc cttgacttga ggttagattt tttttatatt ttgttttgtg ttattttttt     1980

ctttaacatc cctaaaattt tccttagatg ttttactagc cagatttttc ctcctctcct     2040

gactactccc agtcatagct gtccctcttc tcttatggag atccctcgag gacatgaggt     2100

cgtcgctgta atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc     2160

acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat     2220

tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt     2280

tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtcga     2340

cactgggtcg tgatcgggta cctaacttta aataatgcca attatttaaa gttagctagc     2400

tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga     2460

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa     2520

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc     2580

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc     2640

gacggttgcc ctctttccca agttttagag ctaggccaac atgaggatca cccatgtctg     2700

cagggcctag caagttaaaa taaggctagt ccgttatcaa cttggccaac atgaggatca     2760

cccatgtctg cagggccaag tggcaccgag tcggtgcttt ttttgtttta gagctagaaa     2820

tagcaagtta aaataaggct agtccgtttt gagctccata agactcggcc ttagaacaag     2880

ctttttccca tgattccttc atatttgcat atacgataca aggctgttag agagataatt     2940

ggaattaatt tgactgtaaa cacaaagata ttagtacaaa atacgtgacg tagaaagtaa     3000

taatttcttg ggtagtttgc agttttaaaa ttatgtttta aaatggacta tcatatgctt     3060

accgtaactt gaaagtattt cgatttcttg gctttatata tcttgtggaa aggacgaaac     3120

accgactgtc agactcaaag gtgcgtttta gagctaggcc aacatgagga tcacccatgt     3180

ctgcagggcc tagcaagtta aaataaggct agtccgttat caacttggcc aacatgagga     3240

tcacccatgt ctgcagggcc aagtggcacc gagtcggtgc tttttttgtt ttagagctag     3300

aaatagcaag ttaaaataag gctagtccgt tttatgcatg tggctcccat ttatacctgg     3360

ccggctttcc catgattcct tcatatttgc atatacgata caaggctgtt agagagataa     3420

ttggaattaa tttgactgta aacacaaaga tattagtaca aaatacgtga cgtagaaagt     3480

aataatttct tgggtagttt gcagttttaa aattatgttt taaaatggac tatcatatgc     3540

ttaccgtaac ttgaaagtat ttcgatttct tggctttata tatcttgtgg aaaggacgaa     3600

acaccgacaa taagtagtct tactcgtttt agagctaggc caacatgagg atcacccatg     3660

tctgcagggc ctagcaagtt aaaataaggc tagtccgtta tcaacttggc caacatgagg     3720

atcacccatg tctgcagggc caagtggcac cgagtcggtg ctttttttgt tttagagcta     3780

gaaatagcaa gttaaaataa ggctagtccg tttt                                 3814


<210> 66
<211> 1414
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 66
tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga       60

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa      120

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc      180

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc      240

gacggttgcc ctctttccca agttttagag ctaggccaac atgaggatca cccatgtctg      300

cagggcctag caagttaaaa taaggctagt ccgttatcaa cttggccaac atgaggatca      360

cccatgtctg cagggccaag tggcaccgag tcggtgcttt ttttgtttta gagctagaaa      420

tagcaagtta aaataaggct agtccgtttt gagctccata agactcggcc ttagaacaag      480

ctttttccca tgattccttc atatttgcat atacgataca aggctgttag agagataatt      540

ggaattaatt tgactgtaaa cacaaagata ttagtacaaa atacgtgacg tagaaagtaa      600

taatttcttg ggtagtttgc agttttaaaa ttatgtttta aaatggacta tcatatgctt      660

accgtaactt gaaagtattt cgatttcttg gctttatata tcttgtggaa aggacgaaac      720

accgactgtc agactcaaag gtgcgtttta gagctaggcc aacatgagga tcacccatgt      780

ctgcagggcc tagcaagtta aaataaggct agtccgttat caacttggcc aacatgagga      840

tcacccatgt ctgcagggcc aagtggcacc gagtcggtgc tttttttgtt ttagagctag      900

aaatagcaag ttaaaataag gctagtccgt tttatgcatg tggctcccat ttatacctgg      960

ccggctttcc catgattcct tcatatttgc atatacgata caaggctgtt agagagataa     1020

ttggaattaa tttgactgta aacacaaaga tattagtaca aaatacgtga cgtagaaagt     1080

aataatttct tgggtagttt gcagttttaa aattatgttt taaaatggac tatcatatgc     1140

ttaccgtaac ttgaaagtat ttcgatttct tggctttata tatcttgtgg aaaggacgaa     1200

acaccgacaa taagtagtct tactcgtttt agagctaggc caacatgagg atcacccatg     1260

tctgcagggc ctagcaagtt aaaataaggc tagtccgtta tcaacttggc caacatgagg     1320

atcacccatg tctgcagggc caagtggcac cgagtcggtg ctttttttgt tttagagcta     1380

gaaatagcaa gttaaaataa ggctagtccg tttt                                 1414


<210> 67
<211> 1490
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> misc_feature
<222> (28)..(267)
<223> /note="hU6 promoter"

<220>
<221> misc_feature
<222> (269)..(288)
<223> /note="Guide1"

<220>
<221> misc_feature
<222> (289)..(425)
<223> /note="SAM Tracr"

<220>
<221> misc_feature
<222> (426)..(477)
<223> /note="Extended terminator"

<220>
<221> misc_feature
<222> (511)..(750)
<223> /note="hU6 promoter"

<220>
<221> misc_feature
<222> (752)..(771)
<223> /note="Guide2"

<220>
<221> misc_feature
<222> (772)..(908)
<223> /note="SAM Tracr"

<220>
<221> misc_feature
<222> (909)..(960)
<223> /note="Extended terminator"

<220>
<221> misc_feature
<222> (993)..(1232)
<223> /note="hU6 promoter"

<220>
<221> misc_feature
<222> (1233)..(1252)
<223> /note="Guide3"

<220>
<221> misc_feature
<222> (1253)..(1389)
<223> /note="SAM Tracr"

<220>
<221> misc_feature
<222> (1390)..(1441)
<223> /note="Extended terminator"

<400> 67
gctagccata agactcggcc ttagaacttt cccatgattc cttcatattt gcatatacga       60

tacaaggctg ttagagagat aattggaatt aatttgactg taaacacaaa gatattagta      120

caaaatacgt gacgtagaaa gtaataattt cttgggtagt ttgcagtttt aaaattatgt      180

tttaaaatgg actatcatat gcttaccgta acttgaaagt atttcgattt cttggcttta      240

tatatcttgt ggaaaggacg aaacaccgac ggttgccctc tttcccaagt tttagagcta      300

ggccaacatg aggatcaccc atgtctgcag ggcctagcaa gttaaaataa ggctagtccg      360

ttatcaactt ggccaacatg aggatcaccc atgtctgcag ggccaagtgg caccgagtcg      420

gtgctttttt tgttttagag ctagaaatag caagttaaaa taaggctagt ccgttttgag      480

ctccataaga ctcggcctta gaacaagctt tttcccatga ttccttcata tttgcatata      540

cgatacaagg ctgttagaga gataattgga attaatttga ctgtaaacac aaagatatta      600

gtacaaaata cgtgacgtag aaagtaataa tttcttgggt agtttgcagt tttaaaatta      660

tgttttaaaa tggactatca tatgcttacc gtaacttgaa agtatttcga tttcttggct      720

ttatatatct tgtggaaagg acgaaacacc gactgtcaga ctcaaaggtg cgttttagag      780

ctaggccaac atgaggatca cccatgtctg cagggcctag caagttaaaa taaggctagt      840

ccgttatcaa cttggccaac atgaggatca cccatgtctg cagggccaag tggcaccgag      900

tcggtgcttt ttttgtttta gagctagaaa tagcaagtta aaataaggct agtccgtttt      960

atgcatgtgg ctcccattta tacctggccg gctttcccat gattccttca tatttgcata     1020

tacgatacaa ggctgttaga gagataattg gaattaattt gactgtaaac acaaagatat     1080

tagtacaaaa tacgtgacgt agaaagtaat aatttcttgg gtagtttgca gttttaaaat     1140

tatgttttaa aatggactat catatgctta ccgtaacttg aaagtatttc gatttcttgg     1200

ctttatatat cttgtggaaa ggacgaaaca ccgacaataa gtagtcttac tcgttttaga     1260

gctaggccaa catgaggatc acccatgtct gcagggccta gcaagttaaa ataaggctag     1320

tccgttatca acttggccaa catgaggatc acccatgtct gcagggccaa gtggcaccga     1380

gtcggtgctt tttttgtttt agagctagaa atagcaagtt aaaataaggc tagtccgttt     1440

tggtcaccca gtgaggaagc taggacagac ctaggacggt tgcctgcagg                1490


<210> 68
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 68
aggcggucaa uguggcagcc                                                   20


<210> 69
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 69
cauugaccgc cuggggccca                                                   20


<210> 70
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 70
ggggcccaau guauauuuaa                                                   20


<210> 71
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 71
cuggcuccgg cauugcagag                                                   20


<210> 72
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 72
caacaaacag caugcagguu                                                   20


<210> 73
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 73
uucgaggggu cuaggguaga                                                   20


<210> 74
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 74
accacauuac cuuggagggg                                                   20


<210> 75
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 75
ccaagguaau gugguggguc                                                   20


<210> 76
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 76
gacuccacuu uggggccauu                                                   20


<210> 77
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 77
cacaggggga caucaucuac                                                   20


<210> 78
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 78
gcuaguccca gcggcucaga                                                   20


<210> 79
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 79
gauguauuau ucagcucccu                                                   20


<210> 80
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 80
uguggggauu aauguccugc                                                   20


<210> 81
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 81
cgcuguccgu gccacccagc                                                   20


<210> 82
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 82
ggaguuggcc agcuccuguu                                                   20


<210> 83
<211> 964
<212> DNA
<213> Mus sp.

<400> 83
tgcagctcag cctactactt gctttccagg ctgttcctag ttcccatgtc agctgcttgt       60

gctttccaga gacaaaacag gaataataga tgtcattaaa tatacattgg gccccaggcg      120

gtcaatgtgg cagcctgagc ctcctttcca tctctgtgga ggcagacata ggacccccaa      180

caaacagcat gcaggttggg agccagccac aggacccagg taaggggccc tgggtcctta      240

agcttctgcc actggctccg gcattgcaga gagaagagaa ggggcggcag actggagagc      300

tgggctccat ttttgttcct tggtgccctg cccctcccca tgacctgcag agacattcag      360

cctgccaggc tttatgaggt gggagctggg ctctccctga tgtattattc agctccctgg      420

agttggccag ctcctgttac actggccaca gccctgggca tccgcttctc acttctagtt      480

tcccctccaa ggtaatgtgg tgggtcatga tcattctatc ctggcttcag ggacctgact      540

ccactttggg gccattcgag gggtctaggg tagatgatgt ccccctgtgg ggattaatgt      600

cctgctctgt aaaactgagc tagctgagat ccaggagggc ttggccagag acagcaagtt      660

gttgccatgg tgactttaaa gccaggttgc tgccccagca caggcctccc agtctaccct      720

cactagaaaa caacacccag gcactttcca ccacctctca aaggtgaaac ccaaggctgg      780

tctagagaat gaattatgga tcctcgctgt ccgtgccacc cagctagtcc cagcggctca      840

gacactgagg agagactgta ggttcagcta caagcaaaaa gacctagctg gtctccaagc      900

agtgtctcca agtccctgaa cctgtgacac ctgccccagg catcatcagg cacagagggc      960

cacc                                                                   964


<210> 84
<211> 9730
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 84
tggaagggct aattcactcc caaagaagac aagatatcct tgatctgtgg atctaccaca       60

cacaaggcta cttccctgat tagcagaact acacaccagg gccaggggtc agatatccac      120

tgacctttgg atggtgctac aagctagtac cagttgagcc agataaggta gaagaggcca      180

ataaaggaga gaacaccagc ttgttacacc ctgtgagcct gcatgggatg gatgacccgg      240

agagagaagt gttagagtgg aggtttgaca gccgcctagc atttcatcac gtggcccgag      300

agctgcatcc ggagtacttc aagaactgct gatatcgagc ttgctacaag ggactttccg      360

ctggggactt tccagggagg cgtggcctgg gcgggactgg ggagtggcga gccctcagat      420

cctgcatata agcagctgct ttttgcctgt actgggtctc tctggttaga ccagatctga      480

gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct      540

tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc      600

agaccctttt agtcagtgtg gaaaatctct agcagtggcg cccgaacagg gacttgaaag      660

cgaaagggaa accagaggag ctctctcgac gcaggactcg gcttgctgaa gcgcgcacgg      720

caagaggcga ggggcggcga ctggtgagta cgccaaaaat tttgactagc ggaggctaga      780

aggagagaga tgggtgcgag agcgtcagta ttaagcgggg gagaattaga tcgcgatggg      840

aaaaaattcg gttaaggcca gggggaaaga aaaaatataa attaaaacat atagtatggg      900

caagcaggga gctagaacga ttcgcagtta atcctggcct gttagaaaca tcagaaggct      960

gtagacaaat actgggacag ctacaaccat cccttcagac aggatcagaa gaacttagat     1020

cattatataa tacagtagca accctctatt gtgtgcatca aaggatagag ataaaagaca     1080

ccaaggaagc tttagacaag atagaggaag agcaaaacaa aagtaagacc accgcacagc     1140

aagcggccgg ccgctgatct tcagacctgg aggaggagat atgagggaca attggagaag     1200

tgaattatat aaatataaag tagtaaaaat tgaaccatta ggagtagcac ccaccaaggc     1260

aaagagaaga gtggtgcaga gagaaaaaag agcagtggga ataggagctt tgttccttgg     1320

gttcttggga gcagcaggaa gcactatggg cgcagcgtca atgacgctga cggtacaggc     1380

cagacaatta ttgtctggta tagtgcagca gcagaacaat ttgctgaggg ctattgaggc     1440

gcaacagcat ctgttgcaac tcacagtctg gggcatcaag cagctccagg caagaatcct     1500

ggctgtggaa agatacctaa aggatcaaca gctcctgggg atttggggtt gctctggaaa     1560

actcatttgc accactgctg tgccttggaa tgctagttgg agtaataaat ctctggaaca     1620

gatttggaat cacacgacct ggatggagtg ggacagagaa attaacaatt acacaagctt     1680

aatacactcc ttaattgaag aatcgcaaaa ccagcaagaa aagaatgaac aagaattatt     1740

ggaattagat aaatgggcaa gtttgtggaa ttggtttaac ataacaaatt ggctgtggta     1800

tataaaatta ttcataatga tagtaggagg cttggtaggt ttaagaatag tttttgctgt     1860

actttctata gtgaatagag ttaggcaggg atattcacca ttatcgtttc agacccacct     1920

cccaaccccg aggggacccg acaggcccga aggaatagaa gaagaaggtg gagagagaga     1980

cagagacaga tccattcgat tagtgaacgg atctcgacgg tatcgccttt aaaagaaaag     2040

gggggattgg ggggtacagt gcaggggaaa gaatagtaga cataatagca acagacatac     2100

aaactaaaga attacaaaaa caaattacaa aaattcaaaa ttttcgggtt tattacaggg     2160

acagcagaga tccagtttat cgatctgcag ctcagcctac tacttgcttt ccaggctgtt     2220

cctagttccc atgtcagctg cttgtgcttt ccagagacaa aacaggaata atagatgtca     2280

ttaaatatac attgggcccc aggcggtcaa tgtggcagcc tgagcctcct ttccatctct     2340

gtggaggcag acataggacc cccaacaaac agcatgcagg ttgggagcca gccacaggac     2400

ccaggtaagg ggccctgggt ccttaagctt ctgccactgg ctccggcatt gcagagagaa     2460

gagaaggggc ggcagagctg aaccttagcc ttgccttcct gggtaccctt ctgagcctca     2520

ctgtcttctg tgagatgggc aaagtgcggg tgtgactcct tggcaacggt gttacaccag     2580

ggcaggtaaa gttgtagtta tttgtggggt acaccaggac tgttaaaggt gtaactatgg     2640

tctcacccag cattttcact tctaataagt tcaaatgtga tacggcacct ttctaaaaat     2700

tagttttcag ggaaataggg ttcaaaactg gtagtggtag ggtccattct cacgaccccc     2760

aggcctgcta accctgacca agctacctat tacttacctc ctccccctcc ttggctgtga     2820

tcagatccag agcctgaatg agcctcctga ccccacaccc ccactagcat gggcccgcaa     2880

gtgcccagaa gtccctcctg cctcctaaac tgcccagccg atccattagc tcttccttct     2940

tcccagtgaa agaagcaggc acagcctgtc cctcccgttc tacagaaagg aagctacagc     3000

acagggaggg ccaaaggcct tcctgggact agacagttga tcaacagcag gactggagag     3060

ctgggctcca tttttgttcc ttggtgccct gcccctcccc atgacctgca gagacattca     3120

gcctgccagg ctttatgagg tgggagctgg gctctccctg atgtattatt cagctccctg     3180

gagttggcca gctcctgtta cactggccac agccctgggc atccgcttct cacttctagt     3240

ttcccctcca aggtaatgtg gtgggtcatg atcattctat cctggcttca gggacctgac     3300

tccactttgg ggccattcga ggggtctagg gtagatgatg tccccctgtg gggattaatg     3360

tcctgctctg taaaactgag ctagctgaga tccaggaggg cttggccaga gacagcaagt     3420

tgttgccatg gtgactttaa agccaggttg ctgccccagc acaggcctcc cagtctaccc     3480

tcactagaaa acaacaccca ggcactttcc accacctctc aaaggtgaaa cccaaggctg     3540

gtctagagaa tgaattatgg atcctcgctg tccgtgccac ccagctagtc ccagcggctc     3600

agacactgag gagagactgt aggttcagct acaagcaaaa agacctagct ggtctccaag     3660

cagtgtctcc aagtccctga acctgtgaca cctgccccag gcatcatcag gcacagaggg     3720

ccaccgaatt cctcgagact agtatggtga gcaagggcga ggagctgttc accggggtgg     3780

tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc gtgtccggcg     3840

agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc accaccggca     3900

agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg cagtgcttca     3960

gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg cccgaaggct     4020

acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg     4080

tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc gacttcaagg     4140

aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac aacgtctata     4200

tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc cacaacatcg     4260

aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc ggcgacggcc     4320

ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc aaagacccca     4380

acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg atcactctcg     4440

gcatggacga gctgtacaag taagcggccg cggatcccgc ccctctccct cccccccccc     4500

taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt     4560

ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt     4620

gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt     4680

cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct     4740

ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt     4800

ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt     4860

ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa     4920

ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta catgtgttta     4980

gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa     5040

aacacgatga taagcttgcc acaacccaca aggagacgac cttccatgac cgagtacaag     5100

cccacggtgc gcctcgccac ccgcgacgac gtcccccggg ccgtacgcac cctcgccgcc     5160

gcgttcgccg actaccccgc cacgcgccac accgtcgacc cggaccgcca catcgagcgg     5220

gtcaccgagc tgcaagaact cttcctcacg cgcgtcgggc tcgacatcgg caaggtgtgg     5280

gtcgcggacg acggcgccgc ggtggcggtc tggaccacgc cggagagcgt cgaagcgggg     5340

gcggtgttcg ccgagatcgg cccgcgcatg gccgagttga gcggttcccg gctggccgcg     5400

cagcaacaga tggaaggcct cctggcgccg caccggccca aggagcccgc gtggttcctg     5460

gccaccgtcg gcgtctcgcc cgaccaccag ggcaagggtc tgggcagcgc cgtcgtgctc     5520

cccggagtgg aggcggccga gcgcgccggg gtgcccgcct tcctggagac ctccgcgccc     5580

cgcaacctcc ccttctacga gcggctcggc ttcaccgtca ccgccgacgt cgaggtgccc     5640

gaaggaccgc gcacctggtg catgacccgc aagcccggtg cctagacgcg tctggaacaa     5700

tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact atgttgctcc     5760

ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg cttcccgtat     5820

ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg aggagttgtg     5880

gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg     5940

ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc ccctccctat     6000

tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt     6060

gggcactgac aattccgtgg tgttgtcggg gaagctgacg tcctttccat ggctgctcgc     6120

ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt cggccctcaa     6180

tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc cgcgtcttcg     6240

ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgcctg gaattaattc     6300

tgcagtcgag acctagaaaa acatggagca atcacaagta gcaatacagc agctaccaat     6360

gctgattgtg cctggctaga agcacaagag gaggaggagg tgggttttcc agtcacacct     6420

caggtacctt taagaccaat gacttacaag gcagctgtag atcttagcca ctttttaaaa     6480

gaaaagaggg gactggaagg gctaattcac tcccaacgaa gacaagatat ccttgatctg     6540

tggatctacc acacacaagg ctacttccct gattagcaga actacacacc agggccaggg     6600

gtcagatatc cactgacctt tggatggtgc tacaagctag taccagttga gccagataag     6660

gtagaagagg ccaataaagg agagaacacc agcttgttac accctgtgag cctgcatggg     6720

atggatgacc cggagagaga agtgttagag tggaggtttg acagccgcct agcatttcat     6780

cacgtggccc gagagctgca tccggagtac ttcaagaact gctgatatcg agcttgctac     6840

aagggacttt ccgctgggga ctttccaggg aggcgtggcc tgggcgggac tggggagtgg     6900

cgagccctca gatcctgcat ataagcagct gctttttgcc tgtactgggt ctctctggtt     6960

agaccagatc tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca     7020

ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa     7080

ctagagatcc ctcagaccct tttagtcagt gtggaaaatc tctagcagta gtagttcatg     7140

tcatcttatt attcagtatt tataacttgc aaagaaatga atatcagaga gtgagaggcc     7200

ttgacattgc tagcgtttac cgtcgacctc tagctagagc ttggcgtaat catggtcata     7260

gctgtttcct gtgtgaaatt gttatccgct cacaattcca cacaacatac gagccggaag     7320

cataaagtgt aaagcctggg gtgcctaatg agtgagctaa ctcacattaa ttgcgttgcg     7380

ctcactgccc gctttccagt cgggaaacct gtcgtgccag ctgcattaat gaatcggcca     7440

acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc     7500

gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg     7560

gttatccaca gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa     7620

ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga     7680

cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag     7740

ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct     7800

taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg     7860

ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc     7920

ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt     7980

aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta     8040

tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaagaac     8100

agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc     8160

ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat     8220

tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc     8280

tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt     8340

cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta     8400

aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct     8460

atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg     8520

cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga     8580

tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt     8640

atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt     8700

taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt     8760

tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat     8820

gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc     8880

cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc     8940

cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat     9000

gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag     9060

aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt     9120

accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc     9180

ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa     9240

gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg     9300

aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa     9360

taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tcgacggatc     9420

gggagatcaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa     9480

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca     9540

atgtatctta tcatgtctgg atcaactgga taactcaagc taaccaaaat catcccaaac     9600

ttcccacccc ataccctatt accactgcca attacctgtg gtttcattta ctctaaacct     9660

gtgattcctc tgaattattt tcattttaaa gaaattgtat ttgttaaata tgtactacaa     9720

acttagtagt                                                            9730


<210> 85
<211> 5828
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 85
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgtctgca gctcagccta ctacttgctt      180

tccaggctgt tcctagttcc catgtcagct gcttgtgctt tccagagaca aaacaggaat      240

aatagatgtc attaaatata cattgggccc caggcggtca atgtggcctg cagctcagcc      300

tactacttgc tttccaggct gttcctagtt cccatgtcag ctgcttgtgc tttccagaga      360

caaaacagga ataatagatg tcattaaata tacattgggc cccaggcggt caatgtggca      420

gcctgagcct cctttccatc tctgtggagg cagacatagg acccccaaca aacagcatgc      480

aggttgggag ccagccacag gacccaggta aggggccctg ggtccttaag cttctgccac      540

tggctccggc attgcagaga gaagagaagg ggcggcagag ctgaacctta gccttgcctt      600

cctgggtacc cttctgagcc tcactgtctt ctgtgagatg ggcaaagtgc gggtgtgact      660

ccttggcaac ggtgttacac cagggcaggt aaagttgtag ttatttgtgg ggtacaccag      720

gactgttaaa ggtgtaacta tggtctcacc cagcattttc acttctaata agttcaaatg      780

tgatacggca cctttctaaa aattagtttt cagggaaata gggttcaaaa ctggtagtgg      840

tagggtccat tctcacgacc cccaggcctg ctaaccctga ccaagctacc tattacttac      900

ctcctccccc tccttggctg tgatcagatc cagagcctga atgagcctcc tgaccccaca      960

cccccactag catgggcccg caagtgccca gaagtccctc ctgcctccta aactgcccag     1020

ccgatccatt agctcttcct tcttcccagt gaaagaagca ggcacagcct gtccctcccg     1080

ttctacagaa aggaagctac agcacaggga gggccaaagg ccttcctggg actagacagt     1140

tgatcaacag caggactgga gagctgggct ccatttttgt tccttggtgc cctgcccctc     1200

cccatgacct gcagagacat tcagcctgcc aggctttatg aggtgggagc tgggctctcc     1260

ctgatgtatt attcagctcc ctggagttgg ccagctcctg ttacactggc cacagccctg     1320

ggcatccgct tctcacttct agtttcccct ccaaggtaat gtggtgggtc atgatcattc     1380

tatcctggct tcagggacct gactccactt tggggccatt cgaggggtct agggtagatg     1440

atgtccccct gtggggatta atgtcctgct ctgtaaaact gagctagctg agatccagga     1500

gggcttggcc agagacagca agttgttgcc atggtgactt taaagccagg ttgctgcccc     1560

agcacaggcc tcccagtcta ccctcactag aaaacaacac ccaggcactt tccaccacct     1620

ctcaaaggtg aaacccaagg ctggtctaga gaatgaatta tggatcctcg ctgtccgtgc     1680

cacccagcta gtcccagcgg ctcagacact gaggagagac tgtaggttca gctacaagca     1740

aaaagaccta gctggtctcc aagcagtgtc tccaagtccc tgaacctgtg acacctgccc     1800

caggcatcat caggcacaga gggccaccga attcaccatg gtgagcaagg gcgaggagct     1860

gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt     1920

cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagttcat     1980

ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc tgacctacgg     2040

cgtgcagtgc ttcagccgct accccgacca catgaagcag cacgacttct tcaagtccgc     2100

catgcccgaa ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa     2160

gacccgcgcc gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg     2220

catcgacttc aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacaacag     2280

ccacaacgtc tatatcatgg ccgacaagca gaagaacggc atcaaggtga acttcaagat     2340

ccgccacaac atcgaggacg gcagcgtgca gctcgccgac cactaccagc agaacacccc     2400

catcggcgac ggccccgtgc tgctgcccga caaccactac ctgagcaccc agtccgccct     2460

gagcaaagac cccaacgaga agcgcgatca catggtcctg ctggagttcg tgaccgccgc     2520

cgggatcact ctcggcatgg acgagctgta caagtaatag ctcgagagat ctacgggtgg     2580

catccctgtg acccctcccc agtgcctctc ctggccctgg aagttgccac tccagtgccc     2640

accagccttg tcctaataaa attaagttgc atcattttgt ctgactaggt gtccttctat     2700

aatattatgg ggtggagggg ggtggtatgg agcaaggggc aagttgggaa gacaacctgt     2760

agggcctgcg gggtctattg ggaaccaagc tggagtgcag tggcacaatc ttggctcact     2820

gcaatctccg cctcctgggt tcaagcgatt ctcctgcctc agcctcccga gttgttggga     2880

ttccaggcat gcatgaccag gctcagctaa tttttgtttt tttggtagag acggggtttc     2940

accatattgg ccaggctggt ctccaactcc taatctcagg tgatctaccc accttggcct     3000

cccaaattgc tgggattaca ggcgtgaacc actgctccct tccctgtcct tctgattttg     3060

taggtaacca cgtgcggacc gagcggccgc aggaacccct agtgatggag ttggccactc     3120

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     3180

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ctgcctgcag gggcgcctga     3240

tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatacgt caaagcaacc     3300

atagtacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt     3360

gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct     3420

cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg     3480

atttagtgct ttacggcacc tcgaccccaa aaaacttgat ttgggtgatg gttcacgtag     3540

tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa     3600

tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcgggct attcttttga     3660

tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa     3720

atttaacgcg aattttaaca aaatattaac gtttacaatt ttatggtgca ctctcagtac     3780

aatctgctct gatgccgcat agttaagcca gccccgacac ccgccaacac ccgctgacgc     3840

gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga ccgtctccgg     3900

gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac gaaagggcct     3960

cgtgatacgc ctatttttat aggttaatgt catgataata atggtttctt agacgtcagg     4020

tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc     4080

aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag     4140

gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg     4200

ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt     4260

gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt     4320

tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt     4380

attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa     4440

tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag     4500

agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac     4560

aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac     4620

tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac     4680

cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac     4740

tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact     4800

tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg     4860

tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt     4920

tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat     4980

aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta     5040

gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa     5100

tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga     5160

aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac     5220

aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt     5280

tccgaaggta actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc     5340

gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat     5400

cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag     5460

acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc     5520

cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag     5580

cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac     5640

aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg     5700

gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct     5760

atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc     5820

tcacatgt                                                              5828


<210> 86
<211> 7414
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 86
cgcctttgag tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt       60

gagcgaggaa gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat      120

tcattaatgc agctggcacg acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc      180

aattaatgtg agttagctca ctcattaggc accccaggct ttacacttta tgcttccggc      240

tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca gctatgacca      300

tgattacgcc agatttaatt aaggccttaa ttaggctgcg cgctcgctcg ctcactgagg      360

ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc      420

gagcgcgcag agagggagtg gccaactcca tcactagggg ttccttgtag ttaatgatta      480

acccgccatg ctacttatct acgtagccat gctctaggaa gatcggaatt cgcccttaag      540

ctagcggcgc gcccccgggt gcgcggcgtc ggtggtgccg gcggggggcg ccaggtcgca      600

ggcggtgtag ggctccaggc aggcggcgaa ggccatgacg tgcgctatga aggtctgctc      660

ctgcacgccg tgaaccaggt gcgcctgcgg gccgcgcgcg aacaccgcca cgtcctcgcc      720

tgcgtgggtc tcttcgtcca ggggcactgc tgactgctgc cgatactcgg ggctcccgct      780

ctcgctctcg gtaacatccg gccgggcgcc gtccttgagc acatagcctg gaccgtttcc      840

ttaagcgacg catgctcgcg ataggcacct attggtctta ctgacatcca ctttgccttt      900

ctctccacag gaaaacatgg ggcagcaggc caggatgctg cgggcccagg tgaagcggca      960

cacggtgcgg gacaagctga ggctgtgcca gaacttcctg cagaagctgc gcttcctggc     1020

ggacgagccc cagcacagca ttcccgacat cttcatctgg atgatgagca acaacaagcg     1080

tgtcgcctat gcccgtgtgc cctccaagga cctgctcttc tccatcgtgg aggaggagac     1140

tggcaaggac tgcgccaagg tcaagacgct cttccttaag ctgccaggga agcggggctt     1200

cggctcggca ggctggacag tgcaggccaa ggtggagctg tacctgtggc tgggcctcag     1260

caaacagcgc aaggagttcc tgtgcggcct gccctgtggc ttccaggagg tcaaggcagc     1320

ccagggcctg ggcctgcatg ccttcccacc cgtcagcctg gtctacacca agaagcaggc     1380

gttccagctc cgagcgcaca tgtaccaggc ccgcagcctc tttgccgccg acagcagcgg     1440

actctcagac ccctttgccc gcgtcttctt catcaatcag agtcagtgca cagaggtgct     1500

gaatgagacc ctgtgtccca cctgggacca gatgctggtg ttcgacaacc tggagctcta     1560

tggtgaagct catgagctga gggacgatcc gcccatcatt gtcattgaaa tctatgacca     1620

ggattccatg ggcaaagctg acttcatggg ccggaccttc gccaaacccc tggtgaagat     1680

ggcagacgag gcgtactgcc caccccgctt cccacctcag ctcgagtact accagatcta     1740

ccgtggcaac gccacagctg gagacctgct ggcggccttc gagctgctgc agattggacc     1800

agcagggaag gctgacctgc cccccatcaa tggcccggtg gacgtggacc gaggtcccat     1860

catgcccgtg cccatgggca tccggcccgt gctcagcaag taccgagtgg aggtgctgtt     1920

ctggggccta cgggacctaa agcgggtgaa cctggcccag gtggaccggc cacgggtgga     1980

catcgagtgt gcagggaagg gggtgcagtc gtccctgatc cacaattata agaagaaccc     2040

caacttcaac accctcgtca agtggtttga agtggacctc ccagagaacg agctgctgca     2100

cccgcccttg aacatccgtg tggtggactg ccgggccttc ggtcgctaca cactggtggg     2160

ctcccatgcc gtcagctccc tgcgacgctt catctaccgg cccccagacc gctcggcccc     2220

cagctggaac accacggtca ggcttctccg gcgctgccgt gtgctgtgca atgggggctc     2280

ctcctctcac tccacagggg aggttgtggt gactatggag ccagaggtac ccatcaagaa     2340

actggagacc atggtgaagc tggacgcgac ttctgaagct gttgtcaagg tggatgtggc     2400

tgaggaggag aaggagaaga agaagaagaa gaagggcact gcggaggagc cagaggagga     2460

ggagccagac gagagcatgc tggactggtg gtccaagtac tttgcctcca ttgacaccat     2520

gaaggagcaa cttcgacaac aagagccctc tggaattgac ttggaggaga aggaggaagt     2580

ggacaatacc gagggcctga aggggtcaat gaagggcaag gagaaggcaa gggctgccaa     2640

agaggagaag aagaagaaaa ctcagagctc tggctctggc caggggtccg aggcccccga     2700

gaagaagaaa cccaagattg atgagcttaa ggtatacccc aaagagctgg agtccgagtt     2760

tgataacttt gaggactggc tgcacacttt caacttgctt cggggcaaga ccggggatga     2820

tgaggatggc tccaccgagg aggagcgcat tgtgggacgc ttcaagggct ccctctgcgt     2880

gtacaaagtg ccactcccag aggacgtgtc ccgggaagcc ggctacgact ccacctacgg     2940

catgttccag ggcatcccga gcaatgaccc catcaatgtg ctggtccgag tctatgtggt     3000

ccgggccacg gacctgcacc ctgctgacat caacggcaaa gctgacccct acatcgccat     3060

ccggctaggc aagactgaca tccgcgacaa ggagaactac atctccaagc agctcaaccc     3120

tgtctttggg aagtcctttg acatcgaggc ctccttcccc atggaatcca tgctgacggt     3180

ggctgtgtat gactgggacc tggtgggcac tgatgacctc attggggaaa ccaagatcga     3240

cctggagaac cgcttctaca gcaagcaccg cgccacctgc ggcatcgccc agacctactc     3300

cacacatggc tacaatatct ggcgggaccc catgaagccc agccagatcc tgacccgcct     3360

ctgcaaagac ggcaaagtgg acggccccca ctttgggccc cctgggagag tgaaggtggc     3420

caaccgcgtc ttcactgggc cctctgagat tgaggacgag aacggtcaga ggaagcccac     3480

agacgagcat gtggcgctgt tggccctgag gcactgggag gacatccccc gcgcaggctg     3540

ccgcctggtg ccagagcatg tggagacgag gccgctgctc aaccccgaca agccgggcat     3600

cgagcagggc cgcctggagc tgtgggtgga catgttcccc atggacatgc cagcccctgg     3660

gacgcctctg gacatctcac ctcggaagcc caagaagtac gagctgcggg tcatcatctg     3720

gaacacagat gaggtggtct tggaggacga cgacttcttc acaggggaga agtccagtga     3780

catcttcgtg agggggtggc tgaagggcca gcaggaggac aagcaggaca cagacgtcca     3840

ctaccactcc ctcactggcg agggcaactt caactggcgc tacctgttcc ccttcgacta     3900

cctggcggcg gaggagaaga tcgtcatctc caagaaggag tccatgttct cctgggacga     3960

gaccgagtac aagatccccg cgcggctcac cctgcagatc tgggatgcgg accacttctc     4020

cgctgacgac ttcctggggg ccatcgagct ggacctgaac cggttcccgc ggggcgcaaa     4080

gacagccaag cagtgcacca tggagatggc caccggggag gtggacgtgc ccctcgtgtc     4140

catcttcaag caaaagcgcg tcaaaggctg gtggcccctc ctggcccgca atgagaacga     4200

tgagtttgag ctcacgggca aggtggaggc tgagctgcat ttactgacag cagaggaggc     4260

agagaagaac ccagtgggcc tggcccgcaa tgaacctgac cccctagaga aacccaaccg     4320

gcccgacacg gccttcgtct ggttcctcaa ccctctcaag tccatcaagt acctcatctg     4380

cacccggtac aagtggctca tcatcaagat cgtgctggcg ctgttggggc tgctcatgtt     4440

ggggctcttc ctctacagcc tccctggcta catggtcaaa aagctccttg gggcatgaac     4500

ggccgctatg ctagcttggt accaagggcg gatcctgcat agagctcgct gatcagcctc     4560

gactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac     4620

cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg     4680

tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga     4740

ttgggaagac aatagcaggc atctcgagtt aagggcgaat tcccgataag gatcttccta     4800

gagcatggct acgtagataa gtagcatggc gggttaatca ttaactacaa ggaaccccta     4860

gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca     4920

aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcagc     4980

cttaattaac ctaattcact ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc     5040

gttacccaac ttaatcgcct tgcagcacat ccccctttcg ccagctggcg taatagcgaa     5100

gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atgggacgcg     5160

ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca     5220

cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc     5280

gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct     5340

ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg     5400

ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc     5460

ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg     5520

attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg     5580

aattttaaca aaatattaac gcttacaatt taggtggcac ttttcgggga aatgtgcgcg     5640

gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat     5700

aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagccat attcaacggg     5760

aaacgtcgag gccgcgatta aattccaaca tggatgctga tttatatggg tataaatggg     5820

ctcgcgataa tgtcgggcaa tcaggtgcga caatctatcg cttgtatggg aagcccgatg     5880

cgccagagtt gtttctgaaa catggcaaag gtagcgttgc caatgatgtt acagatgaga     5940

tggtcagact aaactggctg acggaattta tgcctcttcc gaccatcaag cattttatcc     6000

gtactcctga tgatgcatgg ttactcacca ctgcgatccc cggaaaaaca gcattccagg     6060

tattagaaga atatcctgat tcaggtgaaa atattgttga tgcgctggca gtgttcctgc     6120

gccggttgca ttcgattcct gtttgtaatt gtccttttaa cagcgatcgc gtatttcgtc     6180

ttgctcaggc gcaatcacga atgaataacg gtttggttga tgcgagtgat tttgatgacg     6240

agcgtaatgg ctggcctgtt gaacaagtct ggaaagaaat gcataaactt ttgccattct     6300

caccggattc agtcgtcact catggtgatt tctcacttga taaccttatt tttgacgagg     6360

ggaaattaat aggttgtatt gatgttggac gagtcggaat cgcagaccga taccaggatc     6420

ttgccatcct atggaactgc ctcggtgagt tttctccttc attacagaaa cggctttttc     6480

aaaaatatgg tattgataat cctgatatga ataaattgca gtttcatttg atgctcgatg     6540

agtttttcta actgtcagac caagtttact catatatact ttagattgat ttaaaacttc     6600

atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc     6660

cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt     6720

cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac     6780

cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct     6840

tcagcagagc gcagatacca aatactgttc ttctagtgta gccgtagtta ggccaccact     6900

tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg     6960

ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata     7020

aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga     7080

cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag     7140

ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg     7200

agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac     7260

ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca     7320

acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg ttctttcctg     7380

cgttatcccc tgattctgtg gataaccgta ttac                                 7414


<210> 87
<211> 6986
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 87
gcgcgttggc cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc       60

agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac      120

tttatgcttc cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga      180

aacagctatg accatgatta cgccagattt aattaaggcc ttaattaggc tgcgcgctcg      240

ctcgctcact gaggccgccc gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc      300

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctt      360

gtagttaatg attaacccgc catgctactt atctacgtag ccatgctcta ggaagatcgg      420

aattcgccct taagctagcg gcgcgcccaa ttctgcagct cagcctacta cttgctttcc      480

aggctgttcc tagttcccat gtcagctgct tgtgctttcc agagacaaaa caggaataat      540

agatgtcatt aaatatacat tgggccccag gcggtcaatg tggcagcctg agcctccttt      600

ccatctctgt ggaggcagac ataggacccc caacaaacag catgcaggtt gggagccagc      660

cacaggaccc aggtaagggg ccctgggtcc ttaagcttct gccactggct ccggcattgc      720

agagagaaga gaaggggcgg cagactggag agctgggctc catttttgtt ccttggtgcc      780

ctgcccctcc ccatgacctg cagagacatt cagcctgcca ggctttatga ggtgggagct      840

gggctctccc tgatgtatta ttcagctccc tggagttggc cagctcctgt tacactggcc      900

acagccctgg gcatccgctt ctcacttcta gtttcccctc caaggtaatg tggtgggtca      960

tgatcattct atcctggctt cagggacctg actccacttt ggggccattc gaggggtcta     1020

gggtagatga tgtccccctg tggggattaa tgtcctgctc tgtaaaactg agctagctga     1080

gatccaggag ggcttggcca gagacagcaa gttgttgcca tggtgacttt aaagccaggt     1140

tgctgcccca gcacaggcct cccagtctac cctcactaga aaacaacacc caggcacttt     1200

ccaccacctc tcaaaggtga aacccaaggc tggtctagag aatgaattat ggatcctcgc     1260

tgtccgtgcc acccagctag tcccagcggc tcagacactg aggagagact gtaggttcag     1320

ctacaagcaa aaagacctag ctggtctcca agcagtgtct ccaagtccct gaacctgtga     1380

cacctgcccc aggcatcatc aggcacagag ggccaccaag aattctagcg gccgccacca     1440

tggccttgct catccacctc aagacagtct cggagctgcg gggcaggggc gaccggatcg     1500

ccaaagtgac tttccgaggg caatccttct actctcgggt cctggagaac tgtgaggatg     1560

tggctgactt tgatgagaca tttcggtggc cggtggccag cagcatcgac agaaatgaga     1620

tgctggagat tcaggttttc aactacagca aagtcttcag caacaagctc atcgggacct     1680

tccgcatggt gctgcagaag gtggtagagg agagccatgt ggaggtgact gacacgctga     1740

ttgatgacaa caatgctatc atcaagacca gcctgtgcgt ggaggtccgg tatcaggcca     1800

ctgacggcac agtgggctcc tgggacgatg gggacttcct gggagatgag tctcttcaag     1860

aggaagagaa ggacagccaa gagacggatg gactgctccc aggctcccgg cccagctccc     1920

ggcccccagg agagaagagc ttccggagag ccgggaggag cgtgttctcc gccatgaagc     1980

tcggcaaaaa ccggtctcac aaggaggagc cccaaagacc agatgaaccg gcggtgctgg     2040

agatggaaga ccttgaccat ctggccattc ggctaggaga tggactggat cccgactcgg     2100

tgtctctagc ctcagtcaca gctctcacca ctaatgtctc caacaagcga tctaagccag     2160

acattaagat ggagccaagt gctgggcggc ccatggatta ccaggtcagc atcacggtga     2220

tcgaggcccg gcagctggtg ggcttgaaca tggaccctgt ggtgtgcgtg gaggtgggtg     2280

acgacaagaa gtacacatcc atgaaggagt ccactaactg cccctattac aacgagtact     2340

tcgtcttcga cttccatgtc tctccggatg tcatgtttga caagatcatc aagatttcgg     2400

tgattcactc caagaacctg ctgcgcagtg gcaccctggt gggctccttc aaaatggacg     2460

tgggaaccgt gtactcgcag ccagagcacc agttccatca caagtgggcc atcctgtctg     2520

accccgatga catctcctcg gggctgaagg gctacgtgaa gtgtgacgtt gccgtggtgg     2580

gcaaagggga caacatcaag acgccccaca aggccaatga gaccgacgaa gatgacattg     2640

aggggaactt gctgctcccc gagggggtgc cccccgaacg ccagtgggcc cggttctatg     2700

tgaaaattta ccgagcagag gggctgcccc gtatgaacac aagcctcatg gccaatgtaa     2760

agaaggcttt catcggtgaa aacaaggacc tcgtggaccc ctacgtgcaa gtcttctttg     2820

ctggccagaa gggcaagact tcagtgcaga agagcagcta tgagcccctg tggaatgagc     2880

aggtcgtctt tacagacctc ttccccccac tctgcaaacg catgaaggtg cagatccgag     2940

actcggacaa ggtcaacgac gtggccatcg gcacccactt cattgacctg cgcaagattt     3000

ctaatgacgg agacaaaggc ttcctgccca cactgggccc agcctgggtg aacatgtacg     3060

gctccacacg taactacacg ctgctggatg agcatcagga cctgaacgag ggcctggggg     3120

agggtgtgtc cttccgggcc cggctcctgc tgggcctggc tgtggagatc gtagacacct     3180

ccaaccctga gctcaccagc tccacagagg tgcaggtgga gcaggccacg cccatctcgg     3240

agagctgtgc aggtaaaatg gaagaattct ttctctttgg agccttcctg gaggcctcaa     3300

tgatcgaccg gagaaacgga gacaagccca tcacctttga ggtcaccata ggcaactatg     3360

ggaacgaagt tgatggcctg tcccggcccc agcggcctcg gccccggaag gagccggggg     3420

atgaggaaga agtagacctg attcagaacg caagtgatga cgaggccggt gatgccgggg     3480

acctggcctc agtctcctcc actccaccaa tgcggcccca ggtcaccgac aggaactact     3540

tccatctgcc ctacctggag cgaaagccct gcatctacat caagagctgg tggccggacc     3600

agcgccgccg cctctacaat gccaacatca tggaccacat tgccgacaag ctggaagaag     3660

gcctgaacga catacaggag atgatcaaaa cggagaagtc ctaccctgag cgtcgcctgc     3720

ggggcgtcct ggaggagctg agctgtggct gctgccgctt cctctccctc gctgacaagg     3780

accagggcca ctcatcccgc accaggcttg accgggagcg cctcaagtcc tgcatgaggg     3840

agctggtaag tatcaaggtt acaagacagg tttaaggaga ccaatagaaa ctgggcttgt     3900

cgagacagag aagactcttg cgtttctgag ctagcccccg ggtgcgcggc gtcggtggtg     3960

ccggcggggg gcgccaggtc gcaggcggtg tagggctcca ggcaggcggc gaaggccatg     4020

acgtgcgcta tgaaggtctg ctcctgcacg ccgtgaacca ggtgcgcctg cgggccgcgc     4080

gcgaacaccg ccacgtcctc gcctgcgtgg gtctcttcgt ccaggggcac tgctgactgc     4140

tgccgatact cggggctccc gctctcgctc tcggtaacat ccggccgggc gccgtccttg     4200

agcacatagc ctggaccgtt tcgtcgacct cgagttaagg gcgaattccc gataaggatc     4260

ttcctagagc atggctacgt agataagtag catggcgggt taatcattaa ctacaaggaa     4320

cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg     4380

cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg     4440

cgcagcctta attaacctaa ttcactggcc gtcgttttac aacgtcgtga ctgggaaaac     4500

cctggcgtta cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat     4560

agcgaagagg cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg     4620

gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc     4680

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc     4740

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt     4800

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg     4860

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt     4920

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta     4980

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt     5040

aacgcgaatt ttaacaaaat attaacgctt acaatttagg tggcactttt cggggaaatg     5100

tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga     5160

gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg agccatattc     5220

aacgggaaac gtcgaggccg cgattaaatt ccaacatgga tgctgattta tatgggtata     5280

aatgggctcg cgataatgtc gggcaatcag gtgcgacaat ctatcgcttg tatgggaagc     5340

ccgatgcgcc agagttgttt ctgaaacatg gcaaaggtag cgttgccaat gatgttacag     5400

atgagatggt cagactaaac tggctgacgg aatttatgcc tcttccgacc atcaagcatt     5460

ttatccgtac tcctgatgat gcatggttac tcaccactgc gatccccgga aaaacagcat     5520

tccaggtatt agaagaatat cctgattcag gtgaaaatat tgttgatgcg ctggcagtgt     5580

tcctgcgccg gttgcattcg attcctgttt gtaattgtcc ttttaacagc gatcgcgtat     5640

ttcgtcttgc tcaggcgcaa tcacgaatga ataacggttt ggttgatgcg agtgattttg     5700

atgacgagcg taatggctgg cctgttgaac aagtctggaa agaaatgcat aaacttttgc     5760

cattctcacc ggattcagtc gtcactcatg gtgatttctc acttgataac cttatttttg     5820

acgaggggaa attaataggt tgtattgatg ttggacgagt cggaatcgca gaccgatacc     5880

aggatcttgc catcctatgg aactgcctcg gtgagttttc tccttcatta cagaaacggc     5940

tttttcaaaa atatggtatt gataatcctg atatgaataa attgcagttt catttgatgc     6000

tcgatgagtt tttctaactg tcagaccaag tttactcata tatactttag attgatttaa     6060

aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca     6120

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     6180

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     6240

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     6300

ctggcttcag cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc     6360

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     6420

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     6480

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     6540

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     6600

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     6660

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     6720

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     6780

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     6840

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     6900

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     6960

gcccaatacg caaaccgcct ctcccc                                          6986


<210> 88
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 88
cgcctcaagt cctgcat                                                      17


<210> 89
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 89
acagcctcag cttgtcc                                                      17


<210> 90
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 90
gcagcaggcc aggatgctgc                                                   20



