                         SEQUENCE LISTING

<110>  APTEVO RESEARCH AND DEVELOPMENT LLC
 
<120>  TUMOR-ASSOCIATED ANTIGENS AND CD3-BINDING PROTEINS, RELATED 
       COMPOSITIONS, AND METHODS

<130>  4897.005PC03

<150>  US 63/166,394
<151>  2021-03-26

<150>  US 63/129,372
<151>  2020-12-22

<150>  US 63/120,154
<151>  2020-12-01

<160>  206   

<170>  PatentIn version 3.5

<210>  1
<211>  2199
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Avi-His-Human PSMA ECD

<400>  1
catcatcacc atcatcatca tcatcaccat ggtctgaatg acatcttcga ggctcagaaa       60

atcgaatggc acgaacataa atcctccaat gaagctacta acattactcc aaagcataat      120

atgaaagcat ttttggatga attgaaagct gagaacatca agaagttctt atataatttt      180

acacagatac cacatttagc aggaacagaa caaaactttc agcttgcaaa gcaaattcaa      240

tcccagtgga aagaatttgg cctggattct gttgagctag cacattatga tgtcctgttg      300

tcctacccaa ataagactca tcccaactac atctcaataa ttaatgaaga tggaaatgag      360

attttcaaca catcattatt tgaaccacct cctccaggat atgaaaatgt ttcggatatt      420

gtaccacctt tcagtgcttt ctctcctcaa ggaatgccag agggcgatct agtgtatgtt      480

aactatgcac gaactgaaga cttctttaaa ttggaacggg acatgaaaat caattgctct      540

gggaaaattg taattgccag atatgggaaa gttttcagag gaaataaggt taaaaatgcc      600

cagctggcag gggccaaagg agtcattctc tactccgacc ctgctgacta ctttgctcct      660

ggggtgaagt cctatccaga tggttggaat cttcctggag gtggtgtcca gcgtggaaat      720

atcctaaatc tgaatggtgc aggagaccct ctcacaccag gttacccagc aaatgaatat      780

gcttataggc gtggaattgc agaggctgtt ggtcttccaa gtattcctgt tcatccaatt      840

ggatactatg atgcacagaa gctcctagaa aaaatgggtg gctcagcacc accagatagc      900

agctggagag gaagtctcaa agtgccctac aatgttggac ctggctttac tggaaacttt      960

tctacacaaa aagtcaagat gcacatccac tctaccaatg aagtgacaag aatttacaat     1020

gtgataggta ctctcagagg agcagtggaa ccagacagat atgtcattct gggaggtcac     1080

cgggactcat gggtgtttgg tggtattgac cctcagagtg gagcagctgt tgttcatgaa     1140

attgtgagga gctttggaac actgaaaaag gaagggtgga gacctagaag aacaattttg     1200

tttgcaagct gggatgcaga agaatttggt cttcttggtt ctactgagtg ggcagaggag     1260

aactcaagac tccttcaaga gcgtggcgtg gcttatatta atgctgactc atctatagaa     1320

ggaaactaca ctctgagagt tgattgtaca ccgctgatgt acagcttggt acacaaccta     1380

acaaaagagc tgaaaagccc tgatgaaggc tttgaaggca aatctcttta tgaaagttgg     1440

actaaaaaaa gtccttcccc agagttcagt ggcatgccca ggataagcaa attgggatct     1500

ggaaatgatt ttgaggtgtt cttccaacga cttggaattg cttcaggcag agcacggtat     1560

actaaaaatt gggaaacaaa caaattcagc ggctatccac tgtatcacag tgtctatgaa     1620

acatatgagt tggtggaaaa gttttatgat ccaatgttta aatatcacct cactgtggcc     1680

caggttcgag gagggatggt gtttgagcta gccaattcca tagtgctccc ttttgattgt     1740

cgagattatg ctgtagtttt aagaaagtat gctgacaaaa tctacagtat ttctatgaaa     1800

catccacagg aaatgaagac atacagtgta tcatttgatt cacttttttc tgcagtaaag     1860

aattttacag aaattgcttc caagttcagt gagagactcc aggactttga caaaagcaac     1920

ccaatagtat taagaatgat gaatgatcaa ctcatgtttc tggaaagagc atttattgat     1980

ccattagggt taccagacag gcctttttat aggcatgtca tctatgctcc aagcagccac     2040

aacaagtatg caggggagtc attcccagga atttatgatg ctctgtttga tattgaaagc     2100

aaagtggacc cttccaaggc ctggggagaa gtgaagagac agatttatgt tgcagccttc     2160

acagtgcagg cagctgcaga gactttgagt gaagtagcc                            2199


<210>  2
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Avi-His-Human PSMA ECD

<400>  2

His His His His His His His His His His Gly Leu Asn Asp Ile Phe 
1               5                   10                  15      


Glu Ala Gln Lys Ile Glu Trp His Glu His Lys Ser Ser Asn Glu Ala 
            20                  25                  30          


Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu Leu 
        35                  40                  45              


Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile Pro 
    50                  55                  60                  


His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile Gln 
65                  70                  75                  80  


Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His Tyr 
                85                  90                  95      


Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile Ser 
            100                 105                 110         


Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe Glu 
        115                 120                 125             


Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro Phe 
    130                 135                 140                 


Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr Val 
145                 150                 155                 160 


Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met Lys 
                165                 170                 175     


Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val Phe 
            180                 185                 190         


Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly Val 
        195                 200                 205             


Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys Ser 
    210                 215                 220                 


Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly Asn 
225                 230                 235                 240 


Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr Pro 
                245                 250                 255     


Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly Leu 
            260                 265                 270         


Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys Leu 
        275                 280                 285             


Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg Gly 
    290                 295                 300                 


Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn Phe 
305                 310                 315                 320 


Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val Thr 
                325                 330                 335     


Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro Asp 
            340                 345                 350         


Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly Gly 
        355                 360                 365             


Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg Ser 
    370                 375                 380                 


Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile Leu 
385                 390                 395                 400 


Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr Glu 
                405                 410                 415     


Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala Tyr 
            420                 425                 430         


Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val Asp 
        435                 440                 445             


Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu Leu 
    450                 455                 460                 


Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser Trp 
465                 470                 475                 480 


Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile Ser 
                485                 490                 495     


Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu Gly 
            500                 505                 510         


Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn Lys 
        515                 520                 525             


Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu Leu 
    530                 535                 540                 


Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val Ala 
545                 550                 555                 560 


Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val Leu 
                565                 570                 575     


Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala Asp 
            580                 585                 590         


Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr Tyr 
        595                 600                 605             


Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr Glu 
    610                 615                 620                 


Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser Asn 
625                 630                 635                 640 


Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu Arg 
                645                 650                 655     


Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg His 
            660                 665                 670         


Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser Phe 
        675                 680                 685             


Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp Pro 
    690                 695                 700                 


Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala Phe 
705                 710                 715                 720 


Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
                725                 730             


<210>  3
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human full length PSMA

<400>  3
atgtggaatc tccttcacga aaccgactcg gctgtggcca ccgcgcgccg cccgcgctgg       60

ctgtgcgctg gggcgctggt gctggcgggt ggcttctttc tcctcggctt cctcttcggg      120

tggtttataa aatcctccaa tgaagctact aacattactc caaagcataa tatgaaagca      180

tttttggatg aattgaaagc tgagaacatc aagaagttct tatataattt tacacagata      240

ccacatttag caggaacaga acaaaacttt cagcttgcaa agcaaattca atcccagtgg      300

aaagaatttg gcctggattc tgttgagcta gcacattatg atgtcctgtt gtcctaccca      360

aataagactc atcccaacta catctcaata attaatgaag atggaaatga gattttcaac      420

acatcattat ttgaaccacc tcctccagga tatgaaaatg tttcggatat tgtaccacct      480

ttcagtgctt tctctcctca aggaatgcca gagggcgatc tagtgtatgt taactatgca      540

cgaactgaag acttctttaa attggaacgg gacatgaaaa tcaattgctc tgggaaaatt      600

gtaattgcca gatatgggaa agttttcaga ggaaataagg ttaaaaatgc ccagctggca      660

ggggccaaag gagtcattct ctactccgac cctgctgact actttgctcc tggggtgaag      720

tcctatccag atggttggaa tcttcctgga ggtggtgtcc agcgtggaaa tatcctaaat      780

ctgaatggtg caggagaccc tctcacacca ggttacccag caaatgaata tgcttatagg      840

cgtggaattg cagaggctgt tggtcttcca agtattcctg ttcatccaat tggatactat      900

gatgcacaga agctcctaga aaaaatgggt ggctcagcac caccagatag cagctggaga      960

ggaagtctca aagtgcccta caatgttgga cctggcttta ctggaaactt ttctacacaa     1020

aaagtcaaga tgcacatcca ctctaccaat gaagtgacaa gaatttacaa tgtgataggt     1080

actctcagag gagcagtgga accagacaga tatgtcattc tgggaggtca ccgggactca     1140

tgggtgtttg gtggtattga ccctcagagt ggagcagctg ttgttcatga aattgtgagg     1200

agctttggaa cactgaaaaa ggaagggtgg agacctagaa gaacaatttt gtttgcaagc     1260

tgggatgcag aagaatttgg tcttcttggt tctactgagt gggcagagga gaactcaaga     1320

ctccttcaag agcgtggcgt ggcttatatt aatgctgact catctataga aggaaactac     1380

actctgagag ttgattgtac accgctgatg tacagcttgg tacacaacct aacaaaagag     1440

ctgaaaagcc ctgatgaagg ctttgaaggc aaatctcttt atgaaagttg gactaaaaaa     1500

agtccttccc cagagttcag tggcatgccc aggataagca aattgggatc tggaaatgat     1560

tttgaggtgt tcttccaacg acttggaatt gcttcaggca gagcacggta tactaaaaat     1620

tgggaaacaa acaaattcag cggctatcca ctgtatcaca gtgtctatga aacatatgag     1680

ttggtggaaa agttttatga tccaatgttt aaatatcacc tcactgtggc ccaggttcga     1740

ggagggatgg tgtttgagct agccaattcc atagtgctcc cttttgattg tcgagattat     1800

gctgtagttt taagaaagta tgctgacaaa atctacagta tttctatgaa acatccacag     1860

gaaatgaaga catacagtgt atcatttgat tcactttttt ctgcagtaaa gaattttaca     1920

gaaattgctt ccaagttcag tgagagactc caggactttg acaaaagcaa cccaatagta     1980

ttaagaatga tgaatgatca actcatgttt ctggaaagag catttattga tccattaggg     2040

ttaccagaca ggccttttta taggcatgtc atctatgctc caagcagcca caacaagtat     2100

gcaggggagt cattcccagg aatttatgat gctctgtttg atattgaaag caaagtggac     2160

ccttccaagg cctggggaga agtgaagaga cagatttatg ttgcagcctt cacagtgcag     2220

gcagctgcag agactttgag tgaagtagcc                                      2250


<210>  4
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human full length PSMA

<400>  4

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 


Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210>  5
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cyno Full length PSMA

<400>  5
atgtggaatc tcctgcacga aaccgactcg gctgtggcca ccgcgcgccg cccgcgctgg       60

ctgtgcgctg gggcactggt gctggcgggt ggcttctttc tcctcggctt cctcttcgga      120

tggtttataa aatcctccag tgaagctact aacattactc caaagcataa tatgaaagca      180

tttttggatg aactgaaagc tgagaacatc aagaagttct tacataattt tacacagata      240

ccacatttag caggaacaga acaaaacttt caacttgcaa agcaaattca atcccagtgg      300

aaagaatttg gcctggattc tgttgagcta actcattatg atgtcctgtt gtcctaccca      360

aataagactc atcccaacta catctcaata attaatgaag atggaaatga gattttcaac      420

acatcattat ttgaaccacc tcctgcagga tatgaaaatg tttcggatat tgtaccacct      480

ttcagtgctt tctctcctca aggaatgcca gagggcgatc tagtgtatgt taactatgca      540

cgaactgaag acttctttaa attggaacgg gacatgaaaa tcaattgctc tgggaaaatt      600

gtaattgcca gatatgggaa agttttcaga ggaaataagg ttaaaaatgc ccagctggca      660

ggggccacag gagtcattct ctactcagac cctgctgact actttgctcc tggggtaaag      720

tcttatccag atggttggaa tcttcctgga ggtggtgtcc agcgtggaaa tatcctaaat      780

ctgaatggtg caggagaccc tctcacacca ggttacccag caaatgaata tgcttatagg      840

cgtggaatgg cagaggctgt tggtcttcca agtattcccg ttcatccaat tgggtactat      900

gatgcacaga agctcctaga aaaaatgggt ggctcagcat caccagatag cagctggaga      960

ggaagtctca aagtgcccta caatgttgga cctggcttta ctggaaactt ttctacacaa     1020

aaagtcaaga tgcacatcca ctctaccagt gaagtgacaa gaatttacaa tgtgataggt     1080

actctcagag gagcagtgga accagacaga tacgtcattc tgggaggtca ccgggactca     1140

tgggtgtttg gtggtattga ccctcagagt ggagcagctg ttgttcatga aattgtgagg     1200

agctttggaa cgctgaaaaa ggaagggtgg agacctagaa gaacaatttt gtttgcaagc     1260

tgggatgcag aagaatttgg tcttcttggt tctactgaat gggcagagga gaactcaaga     1320

ctccttcaag agcgtggcgt ggcttatatt aatgctgatt cgtctataga aggaaactac     1380

actctgagag ttgattgtac accactgatg tacagcttgg tatacaacct aacaaaagag     1440

ctggaaagcc ctgatgaagg ctttgaaggc aaatctcttt atgaaagttg gactaaaaaa     1500

agtccttccc ccgagttcag tggcatgccc aggataagca aattgggatc tggaaatgat     1560

tttgaggtgt tcttccaacg acttggaatt gcctcaggca gagcacggta tactaaaaat     1620

tgggaaacaa acaaattcag cagctatcca ctgtatcaca gtgtctatga gacatatgag     1680

ttggtggaaa agttttatga tccaatgttt aaatatcacc tcactgtggc ccaggttcga     1740

ggagggatgg tgtttgaact agccaattcc gtagtgctcc cttttgattg tcgagattat     1800

gctgtagttt taagaaagta tgctgacaaa atctacaata tttctatgaa acatccacag     1860

gaaatgaaga catacagtgt atcatttgat tcactttttt ctgcagtaaa gaattttaca     1920

gaaattgctt ccaagttcag tgagagactc cgggactttg acaaaagcaa cccaatatta     1980

ttaagaatga tgaatgatca actcatgttt ctggaaagag catttattga tccattaggg     2040

ttaccagaca gaccttttta taggcatgtc atctatgctc caagcagcca caacaagtat     2100

gcaggggagt cattcccagg aatttatgat gctctgtttg atatcgaaag caaagtggac     2160

ccttcccagg cctggggaga agtgaagaga cagatttcta ttgcaacctt cacagtgcaa     2220

gcagctgcag agactttgag tgaagtggcc                                      2250


<210>  6
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyno Full length PSMA

<400>  6

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Ser Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu His Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Thr His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Ala Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Thr Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Met Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Ser Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Ser Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val Tyr Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Glu Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Ser Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Val Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Asn Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Arg Asp Phe Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Leu Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 


Pro Ser Gln Ala Trp Gly Glu Val Lys Arg Gln Ile Ser Ile Ala Thr 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210>  7
<211>  2226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   TSC266 Anti PSMA scFv x Anti CD3 scFv

<400>  7
gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      120

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      300

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      360

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      420

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      480

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      540

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      600

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      660

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      720

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      780

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      840

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      900

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      960

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1020

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1080

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1140

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1200

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1260

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1320

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1380

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct     1440

tccctgaata caggaactca gatggcaggt cattctccga attctcaggt ccagctggtg     1500

gagtctgggg gcggagtggt gcagcctggg cggtcactga ggctgtcctg caaggcttct     1560

ggctacacct ttactagatc tacgatgcac tgggtaaggc aggcccctgg acaaggtctg     1620

gaatggattg gatacattaa tcctagcagt gcttatacta attacaatca gaaattcaag     1680

gacaggttca caatcagcgc agacaaatcc aagagcacag ccttcctgca gatggacagc     1740

ctgaggcccg aggacaccgg cgtctatttc tgtgcacggc cccaagtcca ctatgattac     1800

aacgggtttc cttactgggg ccaagggact cccgtcactg tctctagcgg tggcggaggg     1860

tctgggggtg gcggatccgg aggtggtggc tctgcacaag acatccagat gacccagtct     1920

ccaagcagcc tgtctgcaag cgtgggggac agggtcacca tgacctgcag tgccagctca     1980

agtgtaagtt acatgaactg gtaccagcag aagccgggca aggcccccaa aagatggatt     2040

tatgactcat ccaaactggc ttctggagtc cctgctcgct tcagtggcag tgggtctggg     2100

accgactata ccctcacaat cagcagcctg cagcccgaag atttcgccac ttattactgc     2160

cagcagtgga gtcgtaaccc acccacgttc ggagggggga ccaagctaca aattacatcc     2220

tccagc                                                                2226


<210>  8
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   TSC266 Anti PSMA scFv x Anti CD3 scFv

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser 
465                 470                 475                 480 


Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln 
                485                 490                 495     


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
            500                 505                 510         


Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr 
        515                 520                 525             


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
545                 550                 555                 560 


Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu 
                565                 570                 575     


Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala 
            580                 585                 590         


Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser 
625                 630                 635                 640 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
                645                 650                 655     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            660                 665                 670         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        675                 680                 685             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
    690                 695                 700                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
705                 710                 715                 720 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
                725                 730                 735     


Gln Ile Thr Ser Ser Ser 
            740         


<210>  9
<211>  1524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC291 Anti PSMA scFv-linker Anti CD3 scFv- His

<400>  9
caggtgcagc tggtcgagtc tggcggcgga ctggtcaagc ctggcgagtc cctgagactg       60

tcttgcgctg cctccggctt caccttctcc gactactaca tgtactgggt ccgccaggct      120

cctggcaagg gactggaatg ggtggccatc atctccgacg gcggctacta cacctactac      180

tccgacatca tcaagggccg gttcaccatc tccagggaca acgccaagaa ctccctgtac      240

ctgcagatga actccctgaa ggccgaggac accgccgtgt actactgcgc caggggcttc      300

ccactgctga gacacggcgc catggattac tggggccagg gcaccctggt cacagtgtcc      360

tctggcggag gcggaagtgg aggcggagga agcggaggcg gcggatccga catccagatg      420

acccagtccc catcctccct gtctgcctcc gtgggcgaca gagtgaccat cacatgcaag      480

gcctcccaga acgtggacac caacgtggca tggtatcagc agaagccagg ccaggcccct      540

aagtccctga tctactctgc ctcctaccgg tactccgacg tgccctccag gttctctggc      600

tccgcctctg gcaccgactt caccctgacc atctcttccg tgcagtccga ggacttcgct      660

acctactact gccagcagta cgactcctac ccttacacct tcggcggagg caccaagctg      720

gaaatcaagt ccggcggagg gggctctgaa gtgcagctgg tggaaagcgg agggggactg      780

gtgcagcccg ggggaagtct gaagctgtcc tgtgccgcca gcggctttac cttcaacaag      840

tacgccatga attgggtccg acaggcccca gggaaaggcc tggaatgggt ggcacggatc      900

cggtccaagt acaacaacta cgccacctac tacgctgact ccgtgaagga cagattcacc      960

atcagccggg acgactctaa gaacaccgcc tatctgcaga tgaacaacct gaaaaccgag     1020

gatacagctg tgtactattg tgtgcggcac ggcaacttcg gcaactccta catctcctac     1080

tgggcctatt ggggacaggg aacactggtc accgtgtcta gcggaggtgg cggaagtggg     1140

ggaggcggat ctggcggtgg cggatcccag accgtggtca cccaggaacc ttccctgacc     1200

gtctccccag gcggcaccgt gaccctgacc tgtggctcct ctaccggcgc tgtgacctcc     1260

ggcaactacc ctaactgggt gcagcagaaa cccggacagg ctcctagagg cctgatcggc     1320

ggcaccaagt ttctggcccc tggcacccct gccagattct ccggctccct gctgggaggc     1380

aaggccgctc tgaccctgtc tggcgtgcag cctgaggacg aggccgagta ctactgtgtg     1440

ctgtggtact ccaacagatg ggtgttcgga ggcggcacaa agctgaccgt gctgcatcat     1500

catcatcatc accatcatca tcac                                            1524


<210>  10
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC291 Anti PSMA scFv-linker Anti CD3 scFv- His

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
145                 150                 155                 160 


Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Lys Ser Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
            180                 185                 190         


Asp Val Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asp Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
    290                 295                 300                 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                325                 330                 335     


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
            340                 345                 350         


Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
385                 390                 395                 400 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                405                 410                 415     


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
        435                 440                 445             


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
    450                 455                 460                 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
465                 470                 475                 480 


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                485                 490                 495     


Val Leu His His His His His His His His His His 
            500                 505             


<210>  11
<211>  2271
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRI130 Anti TA scFv x Anti CD3 scFv

<400>  11
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca cagtgtttta tacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      300

cctccgacca ctttcggcgg agggaccaag gtggagatca aaggtggagg cggttcaggc      360

ggaggtggat ccggcggtgg cggctccggt ggcggcggat ctgaggtgca gctgttggag      420

tctgggggag gcttggtaca gcctgggggg tccctgagac tctcctgtgc agcctctgga      480

ttcaccttta gcagctatgg catgagctgg gtccgccagg ctccagggaa ggggctggag      540

ggggtctcag ctattagtgg tagtggtggt agcacatact acgcagactc cgtgaagggc      600

cggttcacca tctccagaga caattccaag aacacgctgt atctgcaaat gaacagcctg      660

agagccgagg acacggccgt atattactgt gcgaaagaaa agttacgata ttttgactgg      720

ttatccgatg cttttgatat ctggggccaa gggacaatgg tcaccgtctc ctcgagtgag      780

cccaaatctt ctgacaaaac tcacacatgc ccaccgtgcc cagcacctga agccgcgggt      840

gcaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      900

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      960

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     1020

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1080

aaggaataca agtgcgcggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1140

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1200

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tccaagcgac     1260

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1320

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1380

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1440

acgcagaaga gcctctccct gtctccgggt tccggaggag ggggttcagg tgggggaggt     1500

tctggcggcg ggggaagccc ttcacaggtg caactggtgc agagtggacc cgaggttaaa     1560

aaaccagggt cctccgttaa ggttagctgc aaagcctctg gctacacatt ttccaggagt     1620

acaatgcact gggtgaggca ggctcctgga cagggactcg agtggatcgg gtatatcaac     1680

ccatctagcg cctataccaa ttacaaccaa aagtttaagg accgagttac cattaccgct     1740

gacaaatcca ccagtacagc ttatatggag ctgtcatctc ttaggtccga ggacactgct     1800

gtttattact gcgctcgtcc tcaggttcac tatgactata atggttttcc ctactggggt     1860

cagggaaccc tggtgactgt ctcttctggc ggtggaggca gcggtggggg tgggtctgga     1920

ggcggtggca gtggcggcgg aggctctgat attcagatga ctcagtctcc tagcactctc     1980

agcgccagcg tgggggatcg tgtgacaatg acttgctccg ctagcagtag tgtgtcttac     2040

atgaattggt atcagcagaa gcccgggaaa gcacctaagc gctggatcta tgactcttcc     2100

aagctggcaa gtggtgtccc ctcacggttc tctggctcag gttctggtac tgactatact     2160

ttgactatct cctccctcca gcccgatgat ttcgctacct attattgtca gcagtggagc     2220

cgtaacccac ccactttcgg aggcggtacc aaagtggaga tcaagaggtc a              2271


<210>  12
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRI130 Anti TA scFv x Anti CD3 scFv

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Gly Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp 
225                 230                 235                 240 


Leu Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
                245                 250                 255     


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Ser Gln Val Gln Leu 
            500                 505                 510         


Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
        515                 520                 525             


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp 
    530                 535                 540                 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
545                 550                 555                 560 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
                565                 570                 575     


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
            580                 585                 590         


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
        595                 600                 605             


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
    610                 615                 620                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
                645                 650                 655     


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
            660                 665                 670         


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
        675                 680                 685             


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
    690                 695                 700                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
705                 710                 715                 720 


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
                725                 730                 735     


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
            740                 745                 750         


Glu Ile Lys Arg Ser 
        755         


<210>  13
<211>  2277
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRI149 Anti TA scFv x Anti CD3 scFv

<400>  13
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagaaaag      300

ttacgatatt ttgactggtt atccgatgct tttgatatct ggggccaagg gacaatggtc      360

accgtctctt caggtggagg cggttcaggc ggaggtggat ccggcggtgg cggctccggt      420

ggcggcggat ctgacatcgt gatgacccag tctccagact ccctggctgt gtctctgggc      480

gagagggcca ccatcaactg caagtccagc caaagtgttt tatacagctc caacaataag      540

aactacttag cttggtacca gcagaaacca ggacagcctc ctaagctgct catttactgg      600

gcatctaccc gggaatccgg ggtccctgac cgattcagtg gcagcgggtc tgggacagat      660

ttcactctca ccatcagcag cctgcaggct gaagatgtgg cagtttatta ctgtcagcaa      720

tattatagta ctcctccgac cactttcggc ggagggacca aggtggagat caaatcctcg      780

agtgagccca aatcttctga caaaactcac acatgcccac cgtgcccagc acctgaagcc      840

gcgggtgcac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      900

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      960

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     1020

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1080

aatggcaagg aatacaagtg cgcggtctcc aacaaagccc tcccagcccc catcgagaaa     1140

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1200

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatcca     1260

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1320

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1380

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1440

cactacacgc agaagagcct ctccctgtct ccgggttccg gaggaggggg ttcaggtggg     1500

ggaggttctg gcggcggggg aagcccttca caggtgcaac tggtgcagag tggacccgag     1560

gttaaaaaac cagggtcctc cgttaaggtt agctgcaaag cctctggcta cacattttcc     1620

aggagtacaa tgcactgggt gaggcaggct cctggacagg gactcgagtg gatcgggtat     1680

atcaacccat ctagcgccta taccaattac aaccaaaagt ttaaggaccg agttaccatt     1740

accgctgaca aatccaccag tacagcttat atggagctgt catctcttag gtccgaggac     1800

actgctgttt attactgcgc tcgtcctcag gttcactatg actataatgg ttttccctac     1860

tggggtcagg gaaccctggt gactgtctct tctggcggtg gaggcagcgg tgggggtggg     1920

tctggaggcg gtggcagtgg cggcggaggc tctgatattc agatgactca gtctcctagc     1980

actctcagcg ccagcgtggg ggatcgtgtg acaatgactt gctccgctag cagtagtgtg     2040

tcttacatga attggtatca gcagaagccc gggaaagcac ctaagcgctg gatctatgac     2100

tcttccaagc tggcaagtgg tgtcccctca cggttctctg gctcaggttc tggtactgac     2160

tatactttga ctatctcctc cctccagccc gatgatttcg ctacctatta ttgtcagcag     2220

tggagccgta acccacccac tttcggaggc ggtaccaaag tggagatcaa gaggtca        2277


<210>  14
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRI149 Anti TA scFv x Anti CD3 scFv

<400>  14

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp Leu Ser Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
145                 150                 155                 160 


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
                165                 170                 175     


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
225                 230                 235                 240 


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
                245                 250                 255     


Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
            260                 265                 270         


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu 
        275                 280                 285             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
305                 310                 315                 320 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                325                 330                 335     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            340                 345                 350         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala 
        355                 360                 365             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    370                 375                 380                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
385                 390                 395                 400 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                405                 410                 415     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            420                 425                 430         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    450                 455                 460                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
465                 470                 475                 480 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Ser Gln Val 
            500                 505                 510         


Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser Ser Val 
        515                 520                 525             


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met 
    530                 535                 540                 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
545                 550                 555                 560 


Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
                565                 570                 575     


Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 
            580                 585                 590         


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        595                 600                 605             


Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly 
    610                 615                 620                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
                645                 650                 655     


Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met 
            660                 665                 670         


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
        675                 680                 685             


Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu 
    690                 695                 700                 


Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
705                 710                 715                 720 


Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr 
                725                 730                 735     


Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr 
            740                 745                 750         


Lys Val Glu Ile Lys Arg Ser 
        755                 


<210>  15
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRI 01043

<400>  15
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca cagtgtttta tacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      300

cctccgacca ctttcggcgg agggaccaag gtggagatca aaggtggagg cggttcaggc      360

ggaggtggat ccggcggtgg cggctccggt ggcggcggat ctgaggtgca gctgttggag      420

tctgggggag gcttggtaca gcctgggggg tccctgagac tctcctgtgc agcctctgga      480

ttcaccttta gcagctatgg catgagctgg gtccgccagg ctccagggaa ggggctggag      540

ggggtctcag ctattagtgg tagtggtggt agcacatact acgcagactc cgtgaagggc      600

cggttcacca tctccagaga caattccaag aacacgctgt atctgcaaat gaacagcctg      660

agagccgagg acacggccgt atattactgt gcgaaagaaa agttacgata ttttgactgg      720

ttatccgatg cttttgatat ctggggccaa gggacaatgg tcaccgtctc ctcgagtgag      780

cccaaatctt ctgacaaaac tcacacatgc ccaccgtgcc cagcacctcc agccgctgca      840

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      900

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      960

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1020

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1080

gaatacaagt gcgcggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1140

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1200

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc aagcgacatc     1260

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1320

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1380

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1440

cagaagagcc tctccctgtc tccgggcggc gggggatccc cgtcacaagt acaactcgtt     1500

caaagtggcg cagaagtaaa gaagccaggc gccagtgtta aggtgagctg caaggcaagc     1560

gggtacacct tcacccggtc tacaatgcac tgggtaagac aagcaccagg gcaaggactc     1620

gaatggattg gttacatcaa cccttcctct gcatacacca actacaatca aaagttccag     1680

ggccgcgtta ctttgacagc ggataaatct acatccacgg cctatatgga actgtcaagc     1740

ctcaggagcg aggacacagc ggtatattac tgtgcatctc cccaggtcca ttatgactac     1800

aacgggtttc cgtactgggg acaaggaact ctggttacag tcagtagcgg tggtggaggt     1860

agtggtggag gcggatctgg cggcggcggt tcaggaggtg gtggatccga tgtccagctt     1920

acccaaagtc cgagcacgtt gagtgcaagt gtaggagacc gcgtaacgat tacttgctct     1980

gcttcaagtt ccgtatccta catgaattgg tatcagcaaa agcctggaaa agcccctaag     2040

cgctggatat acgattcaag taagttggct tctggcgtcc cagcacggtt ttctggttca     2100

ggttccggta cagaatatac gctgacaatc agctctctcc aaccggatga tttcgcaacc     2160

tattactgtc aacaatggtc aagaaatccg ccgacattcg ggcagggaac aaaagtcgag     2220

gtaaaaaggt ca                                                         2232


<210>  16
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRI 01043

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Gly Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp 
225                 230                 235                 240 


Leu Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
                245                 250                 255     


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro 
        275                 280                 285             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
305                 310                 315                 320 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                325                 330                 335     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            340                 345                 350         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn 
        355                 360                 365             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    370                 375                 380                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
385                 390                 395                 400 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                405                 410                 415     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            420                 425                 430         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        435                 440                 445             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    450                 455                 460                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
465                 470                 475                 480 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Pro Ser Gln 
                485                 490                 495     


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
            500                 505                 510         


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr 
        515                 520                 525             


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Gln 
545                 550                 555                 560 


Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
                565                 570                 575     


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
            580                 585                 590         


Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu 
625                 630                 635                 640 


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                645                 650                 655     


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
            660                 665                 670         


Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys 
        675                 680                 685             


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    690                 695                 700                 


Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
705                 710                 715                 720 


Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gln Gly 
                725                 730                 735     


Thr Lys Val Glu Val Lys Arg Ser 
            740                 


<210>  17
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRI 01046 Anti TA scFv x Anti CD3 scFv

<400>  17
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca cagtgtttta tacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      300

cctccgacca ctttcggcgg agggaccaag gtggagatca aaggtggagg cggttcaggc      360

ggaggtggat ccggcggtgg cggctccggt ggcggcggat ctgaggtgca gctgttggag      420

tctgggggag gcttggtaca gcctgggggg tccctgagac tctcctgtgc agcctctgga      480

ttcaccttta gcagctatgg catgagctgg gtccgccagg ctccagggaa ggggctggag      540

ggggtctcag ctattagtgg tagtggtggt agcacatact acgcagactc cgtgaagggc      600

cggttcacca tctccagaga caattccaag aacacgctgt atctgcaaat gaacagcctg      660

agagccgagg acacggccgt atattactgt gcgaaagaaa agttacgata ttttgactgg      720

ttatccgatg cttttgatat ctggggccaa gggacaatgg tcaccgtctc ctcgagtgag      780

cccaaatctt ctgacaaaac tcacacatgc ccaccgtgcc cagcacctcc agccgctgca      840

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      900

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      960

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1020

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1080

gaatacaagt gcgcggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1140

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1200

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc aagcgacatc     1260

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1320

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1380

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1440

cagaagagcc tctccctgtc tccgggcggc gggggatccc cgtcacaagt acaactcgtt     1500

caaagtggcg cagaagtaaa gaagccaggc gccagtgtta aggtgagctg caaggcaagc     1560

gggtacacct tcacccggtc tacaatgcac tgggtaagac aagcaccagg gcaaggactc     1620

gaatggattg gttacatcaa cccttcctct gcatacacca actacgctca aaagttccag     1680

ggccgcgtta ctttgacagc ggataaatct acatccacgg cctatatgga actgtcaagc     1740

ctcaggagcg aggacacagc ggtatattac tgtgcatctc cccaggtcca ttatgactac     1800

aacgggtttc cgtactgggg acaaggaact ctggttacag tcagtagcgg tggtggaggt     1860

agtggtggag gcggatctgg cggcggcggt tcaggaggtg gtggatccga tgtccagctt     1920

acccaaagtc cgagcacgtt gagtgcaagt gtaggagacc gcgtaacgat tacttgctct     1980

gcttcaagtt ccgtatccta catgaattgg tatcagcaaa agcctggaaa agcccctaag     2040

cgctggatat acgattcaag taagttggct tctggcgtcc cagcacggtt ttctggttca     2100

ggttccggta cagaatatac gctgacaatc agctctctcc aaccggatga tttcgcaacc     2160

tattactgtc aacaatggtc aagaaatccg ccgacattcg ggcagggaac aaaagtcgag     2220

gtaaaaaggt ca                                                         2232


<210>  18
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRI 01046 Anti TA scFv x Anti CD3 scFv

<400>  18

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Gly Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp 
225                 230                 235                 240 


Leu Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
                245                 250                 255     


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro 
        275                 280                 285             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
305                 310                 315                 320 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                325                 330                 335     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            340                 345                 350         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn 
        355                 360                 365             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    370                 375                 380                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
385                 390                 395                 400 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                405                 410                 415     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            420                 425                 430         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        435                 440                 445             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    450                 455                 460                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
465                 470                 475                 480 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Pro Ser Gln 
                485                 490                 495     


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
            500                 505                 510         


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr 
        515                 520                 525             


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Ala Gln Lys Phe Gln 
545                 550                 555                 560 


Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
                565                 570                 575     


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
            580                 585                 590         


Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu 
625                 630                 635                 640 


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                645                 650                 655     


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
            660                 665                 670         


Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys 
        675                 680                 685             


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    690                 695                 700                 


Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
705                 710                 715                 720 


Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gln Gly 
                725                 730                 735     


Thr Lys Val Glu Val Lys Arg Ser 
            740                 


<210>  19
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA 01012 Anti-PSMA scFv-Fc

<400>  19
gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      120

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      300

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      360

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      420

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      480

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      540

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      600

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      660

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      720

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      780

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      840

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      900

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      960

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1020

tggctgaatg gcaaggaata caagtgcgcg gtctccaaca aagccctccc agcccccatc     1080

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1140

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1200

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1260

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1320

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1380

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaa                     1425


<210>  20
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 01012 Anti-PSMA scFv-Fc

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  21
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA 01019  Anti-PSMA scFv-Fc

<400>  21
gacgtacaga ttactcaaag cccttcaacc ctgtccgcaa gtgtcgggga cagagttact       60

ataacgtgca gggcaagtaa gagtataagt aaatatctgg cctggtatca acagaaaccc      120

gggaaagccc ctaaactcct catacattca ggatctagcc ttgagtcagg tgttccgtca      180

agattctctg gttccggaag cgggaccgag ttcaccctga caatcagttc actccagcct      240

gacgacttcg ctacttacta ctgccagcag cacatagagt acccctggac attcggacaa      300

ggaacgaaag tcgaaatcaa gggtggtgga ggtagtggtg gaggcggatc tggcggcggc      360

ggttcaggag gtggtggatc cgaggtgcaa cttctcgaat ccggcggtgg gctggtacaa      420

ccgggaggat cccttcgcct ctcttgtgct gcctccgggt ataccttcac ggactactat      480

attcactggg tgcgccaggc gccaggaaag ggattggaat ggatagggag ctttaacccc      540

tacaacgact acacttctta cgccgactct gtaaagggga gagctactct gtccgtcgat      600

aaatcaaaga atacggcata ccttcaaatg aactccctga gggctgagga taccgcagtg      660

tactattgtg caaggagtga tggttactac gacgcgatgg actactgggg ccaaggcacc      720

ctggtcacag tctcctcgag tgagcccaaa tcttctgaca aaactcacac atgcccaccg      780

tgcccagcac ctgaagccgc gggtgcaccg tcagtcttcc tcttcccccc aaaacccaag      840

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      900

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      960

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1020

ctgcaccagg actggctgaa tggcaaggaa tacaagtgcg cggtctccaa caaagccctc     1080

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1140

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1200

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1260

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1320

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1380

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa        1437


<210>  22
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 01019  Anti-PSMA scFv-Fc

<400>  22

Asp Val Gln Ile Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr 
145                 150                 155                 160 


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Ser Phe Asn Pro Tyr Asn Asp Tyr Thr Ser Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Ala Thr Leu Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 


<210>  23
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA 01020 Anti-PSMA scFv-Fc

<400>  23
gacatccaga tgactcaaag cccttcaacc ctgtccgcaa gtgtcgggga cagagttact       60

ataacgtgca gggcaagtaa gagtataagt aaatatctgg cctggtatca acagaaaccc      120

gggaaagccc ctaaactcct catacattca ggatctagcc ttgagtcagg tgttccgtca      180

agattctctg gttccggaag cgggaccgag ttcaccctga caatcagttc actccagcct      240

gacgacttcg ctacttacta ctgccagcag cacatagagt acccctggac attcggacaa      300

ggaacgaaag tcgaaatcaa gggtggtgga ggtagtggtg gaggcggatc tggcggcggc      360

ggttcaggag gtggtggatc cgaggtgcaa cttctcgaat ccggcggtgg gctggtacaa      420

ccgggaggat cccttcgcct ctcttgtgct gcctccgggt ataccttcac ggactactat      480

attcactggg tgcgccaggc gccaggaaag ggattggaat ggatagggag ctttaacccc      540

tacaacgact acacttctta cgccgactct gtaaagggga gagctactct gtccgtcgat      600

aaatcaaaga atacggcata ccttcaaatg aactccctga gggctgagga taccgcagtg      660

tactattgtg caaggagtga tggttactac gacgcgatgg actactgggg ccaaggcacc      720

ctggtcacag tctcctcgag tgagcccaaa tcttctgaca aaactcacac atgcccaccg      780

tgcccagcac ctgaagccgc gggtgcaccg tcagtcttcc tcttcccccc aaaacccaag      840

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      900

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      960

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1020

ctgcaccagg actggctgaa tggcaaggaa tacaagtgcg cggtctccaa caaagccctc     1080

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1140

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1200

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1260

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1320

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1380

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa        1437


<210>  24
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 01020 Anti-PSMA scFv-Fc

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr 
145                 150                 155                 160 


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Ser Phe Asn Pro Tyr Asn Asp Tyr Thr Ser Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Ala Thr Leu Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 


<210>  25
<211>  1437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA  01021 Anti-PSMA scFv-Fc

<400>  25

Gly Ala Cys Gly Thr Ala Cys Ala Gly Ala Thr Thr Ala Cys Thr Cys 
1               5                   10                  15      


Ala Ala Ala Gly Cys Cys Cys Thr Thr Cys Ala Ala Cys Cys Cys Thr 
            20                  25                  30          


Gly Thr Cys Cys Gly Cys Ala Ala Gly Thr Gly Thr Cys Gly Gly Gly 
        35                  40                  45              


Gly Ala Cys Ala Gly Ala Gly Thr Thr Ala Cys Thr Ala Thr Ala Ala 
    50                  55                  60                  


Cys Gly Thr Gly Cys Ala Gly Gly Gly Cys Ala Ala Gly Thr Ala Ala 
65                  70                  75                  80  


Gly Ala Gly Thr Ala Thr Ala Ala Gly Thr Ala Ala Ala Thr Ala Thr 
                85                  90                  95      


Cys Thr Gly Gly Cys Cys Thr Gly Gly Thr Ala Thr Cys Ala Ala Cys 
            100                 105                 110         


Ala Gly Ala Ala Ala Cys Cys Cys Gly Gly Gly Ala Ala Ala Gly Cys 
        115                 120                 125             


Cys Cys Cys Thr Ala Ala Ala Cys Thr Cys Cys Thr Cys Ala Thr Ala 
    130                 135                 140                 


Cys Ala Thr Thr Cys Ala Gly Gly Ala Thr Cys Thr Ala Gly Cys Cys 
145                 150                 155                 160 


Thr Thr Gly Ala Gly Thr Cys Ala Gly Gly Thr Gly Thr Thr Cys Cys 
                165                 170                 175     


Gly Thr Cys Ala Ala Gly Ala Thr Thr Cys Thr Cys Thr Gly Gly Thr 
            180                 185                 190         


Thr Cys Cys Gly Gly Ala Ala Gly Cys Gly Gly Gly Ala Cys Cys Gly 
        195                 200                 205             


Ala Gly Thr Thr Cys Ala Cys Cys Cys Thr Gly Ala Cys Ala Ala Thr 
    210                 215                 220                 


Cys Ala Gly Thr Thr Cys Ala Cys Thr Cys Cys Ala Gly Cys Cys Thr 
225                 230                 235                 240 


Gly Ala Cys Gly Ala Cys Thr Thr Cys Gly Cys Thr Ala Cys Thr Thr 
                245                 250                 255     


Ala Cys Thr Ala Cys Thr Gly Cys Cys Ala Gly Cys Ala Gly Cys Ala 
            260                 265                 270         


Cys Ala Thr Ala Gly Ala Gly Thr Ala Cys Cys Cys Cys Thr Gly Gly 
        275                 280                 285             


Ala Cys Ala Thr Thr Cys Gly Gly Ala Cys Ala Ala Gly Gly Ala Ala 
    290                 295                 300                 


Cys Gly Ala Ala Ala Gly Thr Cys Gly Ala Ala Ala Thr Cys Ala Ala 
305                 310                 315                 320 


Gly Gly Gly Thr Gly Gly Thr Gly Gly Ala Gly Gly Thr Ala Gly Thr 
                325                 330                 335     


Gly Gly Thr Gly Gly Ala Gly Gly Cys Gly Gly Ala Thr Cys Thr Gly 
            340                 345                 350         


Gly Cys Gly Gly Cys Gly Gly Cys Gly Gly Thr Thr Cys Ala Gly Gly 
        355                 360                 365             


Ala Gly Gly Thr Gly Gly Thr Gly Gly Ala Thr Cys Cys Cys Ala Gly 
    370                 375                 380                 


Gly Thr Cys Cys Ala Gly Cys Thr Gly Gly Thr Ala Cys Ala Gly Thr 
385                 390                 395                 400 


Cys Thr Gly Gly Gly Gly Cys Thr Gly Ala Gly Gly Thr Gly Ala Ala 
                405                 410                 415     


Gly Ala Ala Gly Cys Cys Thr Gly Gly Gly Gly Cys Thr Thr Cys Ala 
            420                 425                 430         


Gly Thr Gly Ala Ala Gly Gly Thr Cys Thr Cys Cys Thr Gly Cys Ala 
        435                 440                 445             


Ala Gly Gly Cys Thr Thr Cys Thr Gly Gly Ala Thr Ala Cys Ala Cys 
    450                 455                 460                 


Ala Thr Thr Cys Ala Cys Thr Gly Ala Cys Thr Ala Cys Thr Ala Cys 
465                 470                 475                 480 


Ala Thr Gly Cys Ala Cys Thr Gly Gly Gly Thr Gly Cys Gly Ala Cys 
                485                 490                 495     


Ala Gly Gly Cys Cys Cys Cys Thr Gly Gly Ala Cys Ala Ala Gly Gly 
            500                 505                 510         


Gly Cys Thr Thr Gly Ala Gly Thr Gly Gly Ala Thr Gly Gly Gly Ala 
        515                 520                 525             


Thr Ala Thr Thr Thr Thr Ala Ala Thr Cys Cys Thr Thr Ala Thr Ala 
    530                 535                 540                 


Ala Thr Gly Ala Thr Thr Ala Thr Ala Cys Thr Ala Gly Ala Thr Ala 
545                 550                 555                 560 


Cys Gly Cys Ala Cys Ala Gly Ala Ala Gly Thr Thr Cys Cys Ala Gly 
                565                 570                 575     


Gly Gly Cys Ala Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr Gly Ala 
            580                 585                 590         


Cys Cys Ala Gly Gly Gly Ala Cys Ala Cys Gly Thr Cys Thr Ala Thr 
        595                 600                 605             


Cys Ala Gly Cys Ala Cys Ala Gly Cys Cys Thr Ala Cys Ala Thr Gly 
    610                 615                 620                 


Gly Ala Gly Cys Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala 
625                 630                 635                 640 


Gly Ala Thr Cys Thr Gly Ala Cys Gly Ala Cys Ala Cys Gly Gly Cys 
                645                 650                 655     


Cys Gly Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Ala 
            660                 665                 670         


Ala Gly Ala Thr Cys Gly Gly Ala Thr Gly Gly Thr Thr Ala Cys Thr 
        675                 680                 685             


Ala Cys Gly Ala Thr Gly Cys Thr Ala Thr Gly Gly Ala Cys Thr Ala 
    690                 695                 700                 


Cys Thr Gly Gly Gly Gly Thr Cys Ala Ala Gly Gly Ala Ala Cys Cys 
705                 710                 715                 720 


Ala Cys Ala Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr Cys Cys Thr 
                725                 730                 735     


Cys Gly Ala Gly Thr Gly Ala Gly Cys Cys Cys Ala Ala Ala Thr Cys 
            740                 745                 750         


Thr Thr Cys Thr Gly Ala Cys Ala Ala Ala Ala Cys Thr Cys Ala Cys 
        755                 760                 765             


Ala Cys Ala Thr Gly Cys Cys Cys Ala Cys Cys Gly Thr Gly Cys Cys 
    770                 775                 780                 


Cys Ala Gly Cys Ala Cys Cys Thr Gly Ala Ala Gly Cys Cys Gly Cys 
785                 790                 795                 800 


Gly Gly Gly Thr Gly Cys Ala Cys Cys Gly Thr Cys Ala Gly Thr Cys 
                805                 810                 815     


Thr Thr Cys Cys Thr Cys Thr Thr Cys Cys Cys Cys Cys Cys Ala Ala 
            820                 825                 830         


Ala Ala Cys Cys Cys Ala Ala Gly Gly Ala Cys Ala Cys Cys Cys Thr 
        835                 840                 845             


Cys Ala Thr Gly Ala Thr Cys Thr Cys Cys Cys Gly Gly Ala Cys Cys 
    850                 855                 860                 


Cys Cys Thr Gly Ala Gly Gly Thr Cys Ala Cys Ala Thr Gly Cys Gly 
865                 870                 875                 880 


Thr Gly Gly Thr Gly Gly Thr Gly Gly Ala Cys Gly Thr Gly Ala Gly 
                885                 890                 895     


Cys Cys Ala Cys Gly Ala Ala Gly Ala Cys Cys Cys Thr Gly Ala Gly 
            900                 905                 910         


Gly Thr Cys Ala Ala Gly Thr Thr Cys Ala Ala Cys Thr Gly Gly Thr 
        915                 920                 925             


Ala Cys Gly Thr Gly Gly Ala Cys Gly Gly Cys Gly Thr Gly Gly Ala 
    930                 935                 940                 


Gly Gly Thr Gly Cys Ala Thr Ala Ala Thr Gly Cys Cys Ala Ala Gly 
945                 950                 955                 960 


Ala Cys Ala Ala Ala Gly Cys Cys Gly Cys Gly Gly Gly Ala Gly Gly 
                965                 970                 975     


Ala Gly Cys Ala Gly Thr Ala Cys Ala Ala Cys Ala Gly Cys Ala Cys 
            980                 985                 990         


Gly Thr Ala Cys Cys Gly Thr Gly  Thr Gly Gly Thr Cys  Ala Gly Cys 
        995                 1000                 1005             


Gly Thr  Cys Cys Thr Cys Ala  Cys Cys Gly Thr Cys  Cys Thr Gly 
    1010                 1015                 1020             


Cys Ala  Cys Cys Ala Gly Gly  Ala Cys Thr Gly Gly  Cys Thr Gly 
    1025                 1030                 1035             


Ala Ala  Thr Gly Gly Cys Ala  Ala Gly Gly Ala Ala  Thr Ala Cys 
    1040                 1045                 1050             


Ala Ala  Gly Thr Gly Cys Gly  Cys Gly Gly Thr Cys  Thr Cys Cys 
    1055                 1060                 1065             


Ala Ala  Cys Ala Ala Ala Gly  Cys Cys Cys Thr Cys  Cys Cys Ala 
    1070                 1075                 1080             


Gly Cys  Cys Cys Cys Cys Ala  Thr Cys Gly Ala Gly  Ala Ala Ala 
    1085                 1090                 1095             


Ala Cys  Cys Ala Thr Cys Thr  Cys Cys Ala Ala Ala  Gly Cys Cys 
    1100                 1105                 1110             


Ala Ala  Ala Gly Gly Gly Cys  Ala Gly Cys Cys Cys  Cys Gly Ala 
    1115                 1120                 1125             


Gly Ala  Ala Cys Cys Ala Cys  Ala Gly Gly Thr Gly  Thr Ala Cys 
    1130                 1135                 1140             


Ala Cys  Cys Cys Thr Gly Cys  Cys Cys Cys Cys Ala  Thr Cys Cys 
    1145                 1150                 1155             


Cys Gly  Gly Gly Ala Thr Gly  Ala Gly Cys Thr Gly  Ala Cys Cys 
    1160                 1165                 1170             


Ala Ala  Gly Ala Ala Cys Cys  Ala Gly Gly Thr Cys  Ala Gly Cys 
    1175                 1180                 1185             


Cys Thr  Gly Ala Cys Cys Thr  Gly Cys Cys Thr Gly  Gly Thr Cys 
    1190                 1195                 1200             


Ala Ala  Ala Gly Gly Cys Thr  Thr Cys Thr Ala Thr  Cys Cys Ala 
    1205                 1210                 1215             


Ala Gly  Cys Gly Ala Cys Ala  Thr Cys Gly Cys Cys  Gly Thr Gly 
    1220                 1225                 1230             


Gly Ala  Gly Thr Gly Gly Gly  Ala Gly Ala Gly Cys  Ala Ala Thr 
    1235                 1240                 1245             


Gly Gly  Gly Cys Ala Gly Cys  Cys Gly Gly Ala Gly  Ala Ala Cys 
    1250                 1255                 1260             


Ala Ala  Cys Thr Ala Cys Ala  Ala Gly Ala Cys Cys  Ala Cys Gly 
    1265                 1270                 1275             


Cys Cys  Thr Cys Cys Cys Gly  Thr Gly Cys Thr Gly  Gly Ala Cys 
    1280                 1285                 1290             


Thr Cys  Cys Gly Ala Cys Gly  Gly Cys Thr Cys Cys  Thr Thr Cys 
    1295                 1300                 1305             


Thr Thr  Cys Cys Thr Cys Thr  Ala Cys Ala Gly Cys  Ala Ala Gly 
    1310                 1315                 1320             


Cys Thr  Cys Ala Cys Cys Gly  Thr Gly Gly Ala Cys  Ala Ala Gly 
    1325                 1330                 1335             


Ala Gly  Cys Ala Gly Gly Thr  Gly Gly Cys Ala Gly  Cys Ala Gly 
    1340                 1345                 1350             


Gly Gly  Gly Ala Ala Cys Gly  Thr Cys Thr Thr Cys  Thr Cys Ala 
    1355                 1360                 1365             


Thr Gly  Cys Thr Cys Cys Gly  Thr Gly Ala Thr Gly  Cys Ala Thr 
    1370                 1375                 1380             


Gly Ala  Gly Gly Cys Thr Cys  Thr Gly Cys Ala Cys  Ala Ala Cys 
    1385                 1390                 1395             


Cys Ala  Cys Thr Ala Cys Ala  Cys Gly Cys Ala Gly  Ala Ala Gly 
    1400                 1405                 1410             


Ala Gly  Cys Cys Thr Cys Thr  Cys Cys Cys Thr Gly  Thr Cys Thr 
    1415                 1420                 1425             


Cys Cys  Gly Gly Gly Thr Ala  Ala Ala 
    1430                 1435         


<210>  26
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA  01021 Anti-PSMA scFv-Fc

<400>  26

Asp Val Gln Ile Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln 
            180                 185                 190         


Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Thr Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 


<210>  27
<211>  1437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 01022 Anti PSMA scFv-Fc

<400>  27

Gly Ala Cys Gly Thr Ala Cys Ala Gly Ala Thr Thr Ala Cys Thr Cys 
1               5                   10                  15      


Ala Ala Ala Gly Cys Cys Cys Thr Thr Cys Ala Ala Cys Cys Cys Thr 
            20                  25                  30          


Gly Thr Cys Cys Gly Cys Ala Ala Gly Thr Gly Thr Cys Gly Gly Gly 
        35                  40                  45              


Gly Ala Cys Ala Gly Ala Gly Thr Thr Ala Cys Thr Ala Thr Ala Ala 
    50                  55                  60                  


Cys Gly Thr Gly Cys Ala Gly Gly Gly Cys Ala Ala Gly Thr Ala Ala 
65                  70                  75                  80  


Gly Ala Gly Thr Ala Thr Ala Ala Gly Thr Ala Ala Ala Thr Ala Thr 
                85                  90                  95      


Cys Thr Gly Gly Cys Cys Thr Gly Gly Thr Ala Thr Cys Ala Ala Cys 
            100                 105                 110         


Ala Gly Ala Ala Ala Cys Cys Cys Gly Gly Gly Ala Ala Ala Gly Cys 
        115                 120                 125             


Cys Cys Cys Thr Ala Ala Ala Cys Thr Cys Cys Thr Cys Ala Thr Ala 
    130                 135                 140                 


Cys Ala Thr Thr Cys Ala Gly Gly Ala Thr Cys Thr Ala Gly Cys Cys 
145                 150                 155                 160 


Thr Thr Gly Ala Gly Thr Cys Ala Gly Gly Thr Gly Thr Thr Cys Cys 
                165                 170                 175     


Gly Thr Cys Ala Ala Gly Ala Thr Thr Cys Thr Cys Thr Gly Gly Thr 
            180                 185                 190         


Thr Cys Cys Gly Gly Ala Ala Gly Cys Gly Gly Gly Ala Cys Cys Gly 
        195                 200                 205             


Ala Gly Thr Thr Cys Ala Cys Cys Cys Thr Gly Ala Cys Ala Ala Thr 
    210                 215                 220                 


Cys Ala Gly Thr Thr Cys Ala Cys Thr Cys Cys Ala Gly Cys Cys Thr 
225                 230                 235                 240 


Gly Ala Cys Gly Ala Cys Thr Thr Cys Gly Cys Thr Ala Cys Thr Thr 
                245                 250                 255     


Ala Cys Thr Ala Cys Thr Gly Cys Cys Ala Gly Cys Ala Gly Cys Ala 
            260                 265                 270         


Cys Ala Thr Ala Gly Ala Gly Thr Ala Cys Cys Cys Cys Thr Gly Gly 
        275                 280                 285             


Ala Cys Ala Thr Thr Cys Gly Gly Ala Cys Ala Ala Gly Gly Ala Ala 
    290                 295                 300                 


Cys Gly Ala Ala Ala Gly Thr Cys Gly Ala Ala Ala Thr Cys Ala Ala 
305                 310                 315                 320 


Gly Gly Gly Thr Gly Gly Thr Gly Gly Ala Gly Gly Thr Ala Gly Thr 
                325                 330                 335     


Gly Gly Thr Gly Gly Ala Gly Gly Cys Gly Gly Ala Thr Cys Thr Gly 
            340                 345                 350         


Gly Cys Gly Gly Cys Gly Gly Cys Gly Gly Thr Thr Cys Ala Gly Gly 
        355                 360                 365             


Ala Gly Gly Thr Gly Gly Thr Gly Gly Ala Thr Cys Cys Cys Ala Gly 
    370                 375                 380                 


Gly Thr Cys Cys Ala Gly Cys Thr Gly Gly Thr Ala Cys Ala Gly Thr 
385                 390                 395                 400 


Cys Thr Gly Gly Gly Gly Cys Thr Gly Ala Gly Gly Thr Gly Ala Ala 
                405                 410                 415     


Gly Ala Ala Gly Cys Cys Thr Gly Gly Gly Gly Cys Thr Thr Cys Ala 
            420                 425                 430         


Gly Thr Gly Ala Ala Gly Gly Thr Cys Thr Cys Cys Thr Gly Cys Ala 
        435                 440                 445             


Ala Gly Gly Cys Thr Thr Cys Thr Gly Gly Ala Thr Ala Cys Ala Cys 
    450                 455                 460                 


Ala Thr Thr Cys Ala Cys Thr Gly Ala Cys Thr Ala Cys Thr Ala Cys 
465                 470                 475                 480 


Ala Thr Gly Cys Ala Cys Thr Gly Gly Gly Thr Gly Cys Gly Ala Cys 
                485                 490                 495     


Ala Gly Gly Cys Cys Cys Cys Thr Gly Gly Ala Cys Ala Ala Gly Gly 
            500                 505                 510         


Gly Cys Thr Thr Gly Ala Gly Thr Gly Gly Ala Thr Gly Gly Gly Ala 
        515                 520                 525             


Thr Ala Thr Thr Thr Thr Ala Ala Thr Cys Cys Thr Thr Ala Thr Ala 
    530                 535                 540                 


Ala Thr Gly Ala Thr Thr Ala Thr Ala Cys Thr Ala Gly Ala Thr Ala 
545                 550                 555                 560 


Cys Gly Cys Ala Cys Ala Gly Ala Ala Gly Thr Thr Cys Cys Ala Gly 
                565                 570                 575     


Gly Gly Cys Ala Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr Gly Ala 
            580                 585                 590         


Cys Cys Ala Gly Gly Gly Ala Cys Ala Cys Gly Thr Cys Thr Ala Cys 
        595                 600                 605             


Cys Ala Gly Cys Ala Cys Ala Gly Thr Gly Thr Ala Cys Ala Thr Gly 
    610                 615                 620                 


Gly Ala Gly Cys Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala 
625                 630                 635                 640 


Gly Ala Thr Cys Thr Gly Ala Gly Gly Ala Cys Ala Cys Gly Gly Cys 
                645                 650                 655     


Cys Gly Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Ala 
            660                 665                 670         


Ala Gly Ala Thr Cys Gly Gly Ala Thr Gly Gly Thr Thr Ala Cys Thr 
        675                 680                 685             


Ala Cys Gly Ala Thr Gly Cys Thr Ala Thr Gly Gly Ala Cys Thr Ala 
    690                 695                 700                 


Cys Thr Gly Gly Gly Gly Thr Cys Ala Ala Gly Gly Ala Ala Cys Cys 
705                 710                 715                 720 


Ala Cys Ala Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr Cys Cys Thr 
                725                 730                 735     


Cys Gly Ala Gly Thr Gly Ala Gly Cys Cys Cys Ala Ala Ala Thr Cys 
            740                 745                 750         


Thr Thr Cys Thr Gly Ala Cys Ala Ala Ala Ala Cys Thr Cys Ala Cys 
        755                 760                 765             


Ala Cys Ala Thr Gly Cys Cys Cys Ala Cys Cys Gly Thr Gly Cys Cys 
    770                 775                 780                 


Cys Ala Gly Cys Ala Cys Cys Thr Gly Ala Ala Gly Cys Cys Gly Cys 
785                 790                 795                 800 


Gly Gly Gly Thr Gly Cys Ala Cys Cys Gly Thr Cys Ala Gly Thr Cys 
                805                 810                 815     


Thr Thr Cys Cys Thr Cys Thr Thr Cys Cys Cys Cys Cys Cys Ala Ala 
            820                 825                 830         


Ala Ala Cys Cys Cys Ala Ala Gly Gly Ala Cys Ala Cys Cys Cys Thr 
        835                 840                 845             


Cys Ala Thr Gly Ala Thr Cys Thr Cys Cys Cys Gly Gly Ala Cys Cys 
    850                 855                 860                 


Cys Cys Thr Gly Ala Gly Gly Thr Cys Ala Cys Ala Thr Gly Cys Gly 
865                 870                 875                 880 


Thr Gly Gly Thr Gly Gly Thr Gly Gly Ala Cys Gly Thr Gly Ala Gly 
                885                 890                 895     


Cys Cys Ala Cys Gly Ala Ala Gly Ala Cys Cys Cys Thr Gly Ala Gly 
            900                 905                 910         


Gly Thr Cys Ala Ala Gly Thr Thr Cys Ala Ala Cys Thr Gly Gly Thr 
        915                 920                 925             


Ala Cys Gly Thr Gly Gly Ala Cys Gly Gly Cys Gly Thr Gly Gly Ala 
    930                 935                 940                 


Gly Gly Thr Gly Cys Ala Thr Ala Ala Thr Gly Cys Cys Ala Ala Gly 
945                 950                 955                 960 


Ala Cys Ala Ala Ala Gly Cys Cys Gly Cys Gly Gly Gly Ala Gly Gly 
                965                 970                 975     


Ala Gly Cys Ala Gly Thr Ala Cys Ala Ala Cys Ala Gly Cys Ala Cys 
            980                 985                 990         


Gly Thr Ala Cys Cys Gly Thr Gly  Thr Gly Gly Thr Cys  Ala Gly Cys 
        995                 1000                 1005             


Gly Thr  Cys Cys Thr Cys Ala  Cys Cys Gly Thr Cys  Cys Thr Gly 
    1010                 1015                 1020             


Cys Ala  Cys Cys Ala Gly Gly  Ala Cys Thr Gly Gly  Cys Thr Gly 
    1025                 1030                 1035             


Ala Ala  Thr Gly Gly Cys Ala  Ala Gly Gly Ala Ala  Thr Ala Cys 
    1040                 1045                 1050             


Ala Ala  Gly Thr Gly Cys Gly  Cys Gly Gly Thr Cys  Thr Cys Cys 
    1055                 1060                 1065             


Ala Ala  Cys Ala Ala Ala Gly  Cys Cys Cys Thr Cys  Cys Cys Ala 
    1070                 1075                 1080             


Gly Cys  Cys Cys Cys Cys Ala  Thr Cys Gly Ala Gly  Ala Ala Ala 
    1085                 1090                 1095             


Ala Cys  Cys Ala Thr Cys Thr  Cys Cys Ala Ala Ala  Gly Cys Cys 
    1100                 1105                 1110             


Ala Ala  Ala Gly Gly Gly Cys  Ala Gly Cys Cys Cys  Cys Gly Ala 
    1115                 1120                 1125             


Gly Ala  Ala Cys Cys Ala Cys  Ala Gly Gly Thr Gly  Thr Ala Cys 
    1130                 1135                 1140             


Ala Cys  Cys Cys Thr Gly Cys  Cys Cys Cys Cys Ala  Thr Cys Cys 
    1145                 1150                 1155             


Cys Gly  Gly Gly Ala Thr Gly  Ala Gly Cys Thr Gly  Ala Cys Cys 
    1160                 1165                 1170             


Ala Ala  Gly Ala Ala Cys Cys  Ala Gly Gly Thr Cys  Ala Gly Cys 
    1175                 1180                 1185             


Cys Thr  Gly Ala Cys Cys Thr  Gly Cys Cys Thr Gly  Gly Thr Cys 
    1190                 1195                 1200             


Ala Ala  Ala Gly Gly Cys Thr  Thr Cys Thr Ala Thr  Cys Cys Ala 
    1205                 1210                 1215             


Ala Gly  Cys Gly Ala Cys Ala  Thr Cys Gly Cys Cys  Gly Thr Gly 
    1220                 1225                 1230             


Gly Ala  Gly Thr Gly Gly Gly  Ala Gly Ala Gly Cys  Ala Ala Thr 
    1235                 1240                 1245             


Gly Gly  Gly Cys Ala Gly Cys  Cys Gly Gly Ala Gly  Ala Ala Cys 
    1250                 1255                 1260             


Ala Ala  Cys Thr Ala Cys Ala  Ala Gly Ala Cys Cys  Ala Cys Gly 
    1265                 1270                 1275             


Cys Cys  Thr Cys Cys Cys Gly  Thr Gly Cys Thr Gly  Gly Ala Cys 
    1280                 1285                 1290             


Thr Cys  Cys Gly Ala Cys Gly  Gly Cys Thr Cys Cys  Thr Thr Cys 
    1295                 1300                 1305             


Thr Thr  Cys Cys Thr Cys Thr  Ala Cys Ala Gly Cys  Ala Ala Gly 
    1310                 1315                 1320             


Cys Thr  Cys Ala Cys Cys Gly  Thr Gly Gly Ala Cys  Ala Ala Gly 
    1325                 1330                 1335             


Ala Gly  Cys Ala Gly Gly Thr  Gly Gly Cys Ala Gly  Cys Ala Gly 
    1340                 1345                 1350             


Gly Gly  Gly Ala Ala Cys Gly  Thr Cys Thr Thr Cys  Thr Cys Ala 
    1355                 1360                 1365             


Thr Gly  Cys Thr Cys Cys Gly  Thr Gly Ala Thr Gly  Cys Ala Thr 
    1370                 1375                 1380             


Gly Ala  Gly Gly Cys Thr Cys  Thr Gly Cys Ala Cys  Ala Ala Cys 
    1385                 1390                 1395             


Cys Ala  Cys Thr Ala Cys Ala  Cys Gly Cys Ala Gly  Ala Ala Gly 
    1400                 1405                 1410             


Ala Gly  Cys Cys Thr Cys Thr  Cys Cys Cys Thr Gly  Thr Cys Thr 
    1415                 1420                 1425             


Cys Cys  Gly Gly Gly Thr Ala  Ala Ala 
    1430                 1435         


<210>  28
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 01022 Anti PSMA scFv-Fc

<400>  28

Asp Val Gln Ile Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln 
            180                 185                 190         


Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Thr Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 


<210>  29
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA 01023 Anti PSMA scFv-Fc

<400>  29
gacatccaga tgactcaaag cccttcaacc ctgtccgcaa gtgtcgggga cagagttact       60

ataacgtgca gggcaagtaa gagtataagt aaatatctgg cctggtatca acagaaaccc      120

gggaaagccc ctaaactcct catacattca ggatctagcc ttgagtcagg tgttccgtca      180

agattctctg gttccggaag cgggaccgag ttcaccctga caatcagttc actccagcct      240

gacgacttcg ctacttacta ctgccagcag cacatagagt acccctggac attcggacaa      300

ggaacgaaag tcgaaatcaa gggtggtgga ggtagtggtg gaggcggatc tggcggcggc      360

ggttcaggag gtggtggatc ccaggtccag ctggtacagt ctggggctga ggtgaagaag      420

cctggggctt cagtgaaggt ctcctgcaag gcttctggat acacattcac tgactactac      480

atgcactggg tgcgacaggc ccctggacaa gggcttgagt ggatgggata ttttaatcct      540

tataatgatt atactagata cgcacagaag ttccagggca gagtcaccat gaccagggac      600

acgtctacca gcacagtgta catggagctg agcagcctga gatctgagga cacggccgtg      660

tattactgtg caagatcgga tggttactac gatgctatgg actactgggg tcaaggaacc      720

acagtcaccg tctcctcgag tgagcccaaa tcttctgaca aaactcacac atgcccaccg      780

tgcccagcac ctgaagccgc gggtgcaccg tcagtcttcc tcttcccccc aaaacccaag      840

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      900

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      960

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1020

ctgcaccagg actggctgaa tggcaaggaa tacaagtgcg cggtctccaa caaagccctc     1080

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1140

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1200

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1260

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1320

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1380

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa        1437


<210>  30
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 01023 Anti PSMA scFv-Fc

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln 
            180                 185                 190         


Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Thr Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 


<210>  31
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA 01024 Anti-PSMA scFv-Fc

<400>  31
gacgtacaga ttactcaaag cccttcaacc ctgtccgcaa gtgtcgggga cagagttact       60

ataacgtgca gggcaagtaa gagtataagt aaatatctgg cctggtatca acagaaaccc      120

gggaaagccc ctaaactcct catacattca ggatctagcc ttgagtcagg tgttccgtca      180

agattctctg gttccggaag cgggaccgag ttcaccctga caatcagttc actccagcct      240

gacgacttcg ctacttacta ctgccagcag cacatagagt acccctggac attcggacaa      300

ggaacgaaag tcgaaatcaa gggtggtgga ggtagtggtg gaggcggatc tggcggcggc      360

ggttcaggag gtggtggatc ccaggtccag ctggtacagt ctggggctga ggtgaagaag      420

cctggggctt cagtgaaggt ctcctgcaag gcttctggat acacattcac tgactactac      480

atgcactggg tgcgacaggc ccctggacaa gggcttgagt ggatgggaat ttttaatcct      540

tataatgatt atactagtta cgcacagaag ttccagggca gagtcaccat gaccagggac      600

acgtctacca gcacagtgta catggagctg agcagcctga gatctgagga cacggccgtg      660

tattactgtg caagatcgga tggttactac gatgctatgg actactgggg tcaaggaacc      720

acagtcaccg tctcctcgag tgagcccaaa tcttctgaca aaactcacac atgcccaccg      780

tgcccagcac ctgaagccgc gggtgcaccg tcagtcttcc tcttcccccc aaaacccaag      840

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      900

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      960

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1020

ctgcaccagg actggctgaa tggcaaggaa tacaagtgcg cggtctccaa caaagccctc     1080

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1140

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1200

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1260

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1320

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1380

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa        1437


<210>  32
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 01024 Anti-PSMA scFv-Fc

<400>  32

Asp Val Gln Ile Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Ile Phe Asn Pro Tyr Asn Asp Tyr Thr Ser Tyr Ala Gln Lys Phe Gln 
            180                 185                 190         


Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Thr Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 


<210>  33
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA 01025  Anti-PSMA scFv-Fc

<400>  33
gacatccaga tgactcaaag cccttcaacc ctgtccgcaa gtgtcgggga cagagttact       60

ataacgtgca gggcaagtaa gagtataagt aaatatctgg cctggtatca acagaaaccc      120

gggaaagccc ctaaactcct catacattca ggatctagcc ttgagtcagg tgttccgtca      180

agattctctg gttccggaag cgggaccgag ttcaccctga caatcagttc actccagcct      240

gacgacttcg ctacttacta ctgccagcag cacatagagt acccctggac attcggacaa      300

ggaacgaaag tcgaaatcaa gggtggtgga ggtagtggtg gaggcggatc tggcggcggc      360

ggttcaggag gtggtggatc ccaggtccag ctggtacagt ctggggctga ggtgaagaag      420

cctggggctt cagtgaaggt ctcctgcaag gcttctggat acacattcac tgactactac      480

atgcactggg tgcgacaggc ccctggacaa gggcttgagt ggatgggaat ttttaatcct      540

tataatgatt atactagtta cgcacagaag ttccagggca gagtcaccat gaccagggac      600

acgtctacca gcacagtgta catggagctg agcagcctga gatctgagga cacggccgtg      660

tattactgtg caagatcgga tggttactac gatgctatgg actactgggg tcaaggaacc      720

acagtcaccg tctcctcgag tgagcccaaa tcttctgaca aaactcacac atgcccaccg      780

tgcccagcac ctgaagccgc gggtgcaccg tcagtcttcc tcttcccccc aaaacccaag      840

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      900

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      960

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1020

ctgcaccagg actggctgaa tggcaaggaa tacaagtgcg cggtctccaa caaagccctc     1080

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1140

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1200

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1260

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1320

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1380

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa        1437


<210>  34
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 01025  Anti-PSMA scFv-Fc

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Ile Phe Asn Pro Tyr Asn Asp Tyr Thr Ser Tyr Ala Gln Lys Phe Gln 
            180                 185                 190         


Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Thr Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 


<210>  35
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA 01036  Anti-PSMA scFv-Fc

<400>  35
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtaa gagtattagt aagtacttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatccattct ggctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag catattgaat atccttggac gttcggccaa      300

gggaccaagg tggaaatcaa aggtggtgga ggtagtggtg gaggcggatc tggcggcggc      360

ggttcaggag gtggtggatc ccaggtgcag ctggtgcagt ctggggctga ggtgaagaag      420

cctggggcct cagtgaaggt ttcctgcaag gcatctggat acaccttcac cgactactat      480

atgcactggg tgcgacaggc ccctggacaa gggcttgagt ggatgggata tttcaaccct      540

tataatgatt acacacgcta cgcacagaag ttccagggca gagtcaccat gaccagggac      600

acgtccacga gcacagtcta catggagctg agcagcctga gatctgagga cacggccgtg      660

tattactgtg cgagatctga cggctactac gacgctatgg actactgggg gcaagggacc      720

acggtcaccg tctcctcgag tgagcccaaa tcttctgaca aaactcacac atgcccaccg      780

tgcccagcac ctccagccgc tgcaccgtca gtcttcctct tccccccaaa acccaaggac      840

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      900

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      960

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1020

caccaggact ggctgaatgg caaggaatac aagtgcgcgg tctccaacaa agccctccca     1080

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1140

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc     1200

aaaggcttct atccaagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1260

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1320

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1380

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1434


<210>  36
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 01036  Anti-PSMA scFv-Fc

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln 
            180                 185                 190         


Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Thr Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    290                 295                 300                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475             


<210>  37
<211>  1440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA 01037 Anti-PSMA scFv-Fc

<400>  37
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatat ttcaaccctt ataatgatta cacacgctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatctgac      300

ggctactacg acgctatgga ctactggggg caagggacca cggtcaccgt ctcctcgggt      360

ggtggaggta gtggtggagg cggatctggc ggcggcggtt caggaggtgg tggatccgac      420

atccagatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc      480

acttgccggg ccagtaagag tattagtaag tacttggcct ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ccattctggc tccagtttgg aaagtggggt cccatcaagg      600

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat      660

gattttgcaa cttattactg ccaacagcat attgaatatc cttggacgtt cggccaaggg      720

accaaggtgg aaatcaaatc ctcgagtgag cccaaatctt ctgacaaaac tcacacatgc      780

ccaccgtgcc cagcacctcc agccgctgca ccgtcagtct tcctcttccc cccaaaaccc      840

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      900

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      960

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1020

gtcctgcacc aggactggct gaatggcaag gaatacaagt gcgcggtctc caacaaagcc     1080

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1140

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc     1200

ctggtcaaag gcttctatcc aagcgacatc gccgtggagt gggagagcaa tgggcagccg     1260

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1320

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1380

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1440


<210>  38
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 01037 Anti-PSMA scFv-Fc

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile His Ser Gly Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser 
            260                 265                 270         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        275                 280                 285             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    290                 295                 300                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
305                 310                 315                 320 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                325                 330                 335     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            340                 345                 350         


Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        355                 360                 365             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    370                 375                 380                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
385                 390                 395                 400 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                405                 410                 415     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            420                 425                 430         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        435                 440                 445             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    450                 455                 460                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 480 


<210>  39
<211>  1455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA 01040 Fc-linker anti PSMA scFv

<400>  39
tcctcggagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctcca       60

gccgctgcac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      120

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      180

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      240

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      300

aatggcaagg aatacaagtg cgcggtctcc aacaaagccc tcccagcccc catcgagaaa      360

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc      420

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatcca      480

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg      540

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag      600

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac      660

cactacacgc agaagagcct ctccctgtct ccgggcggcg ggggatcccc gtcagacatc      720

cagatgaccc agtctccttc caccctgtct gcatctgtag gagacagagt caccatcact      780

tgccgggcca gtaagagtat tagtaagtac ttggcctggt atcagcagaa accagggaaa      840

gcccctaagc tcctgatcca ttctggctcc agtttggaaa gtggggtccc atcaaggttc      900

agcggcagtg gatctgggac agaattcact ctcaccatca gcagcctgca gcctgatgat      960

tttgcaactt attactgcca acagcatatt gaatatcctt ggacgttcgg ccaagggacc     1020

aaggtggaaa tcaaaggtgg tggaggtagt ggtggaggcg gatctggcgg cggcggttca     1080

ggaggtggtg gatcccaggt gcagctggtg cagtctgggg ctgaggtgaa gaagcctggg     1140

gcctcagtga aggtttcctg caaggcatct ggatacacct tcaccgacta ctatatgcac     1200

tgggtgcgac aggcccctgg acaagggctt gagtggatgg gatatttcaa cccttataat     1260

gattacacac gctacgcaca gaagttccag ggcagagtca ccatgaccag ggacacgtcc     1320

acgagcacag tctacatgga gctgagcagc ctgagatctg aggacacggc cgtgtattac     1380

tgtgcgagat ctgacggcta ctacgacgct atggactact gggggcaagg gaccacggtc     1440

accgtctcct cgcgc                                                      1455


<210>  40
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 01040 Fc-linker anti PSMA scFv

<400>  40

Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Pro Ser Asp Ile 
225                 230                 235                 240 


Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg 
                245                 250                 255     


Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala 
            260                 265                 270         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile His Ser 
        275                 280                 285             


Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    290                 295                 300                 


Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp 
305                 310                 315                 320 


Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp Thr Phe 
                325                 330                 335     


Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
        355                 360                 365             


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
    370                 375                 380                 


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His 
385                 390                 395                 400 


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe 
                405                 410                 415     


Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg 
            420                 425                 430         


Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu 
        435                 440                 445             


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser 
    450                 455                 460                 


Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
465                 470                 475                 480 


Thr Val Ser Ser Arg 
                485 


<210>  41
<211>  1455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA 01041 Fc-linker anti PSMA scFv

<400>  41
tcctcggagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctcca       60

gccgctgcac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      120

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      180

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      240

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      300

aatggcaagg aatacaagtg cgcggtctcc aacaaagccc tcccagcccc catcgagaaa      360

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc      420

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatcca      480

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg      540

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag      600

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac      660

cactacacgc agaagagcct ctccctgtct ccgggcggcg ggggatcccc gtcacaggtg      720

cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa ggtttcctgc      780

aaggcatctg gatacacctt caccgactac tatatgcact gggtgcgaca ggcccctgga      840

caagggcttg agtggatggg atatttcaac ccttataatg attacacacg ctacgcacag      900

aagttccagg gcagagtcac catgaccagg gacacgtcca cgagcacagt ctacatggag      960

ctgagcagcc tgagatctga ggacacggcc gtgtattact gtgcgagatc tgacggctac     1020

tacgacgcta tggactactg ggggcaaggg accacggtca ccgtctcctc gggtggtgga     1080

ggtagtggtg gaggcggatc tggcggcggc ggttcaggag gtggtggatc cgacatccag     1140

atgacccagt ctccttccac cctgtctgca tctgtaggag acagagtcac catcacttgc     1200

cgggccagta agagtattag taagtacttg gcctggtatc agcagaaacc agggaaagcc     1260

cctaagctcc tgatccattc tggctccagt ttggaaagtg gggtcccatc aaggttcagc     1320

ggcagtggat ctgggacaga attcactctc accatcagca gcctgcagcc tgatgatttt     1380

gcaacttatt actgccaaca gcatattgaa tatccttgga cgttcggcca agggaccaag     1440

gtggaaatca aacgc                                                      1455


<210>  42
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 01041 Fc-linker anti PSMA scFv

<400>  42

Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Pro Ser Gln Val 
225                 230                 235                 240 


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
                245                 250                 255     


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met 
            260                 265                 270         


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr 
        275                 280                 285             


Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly 
    290                 295                 300                 


Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu 
305                 310                 315                 320 


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                325                 330                 335     


Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr 
            340                 345                 350         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        355                 360                 365             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    370                 375                 380                 


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
385                 390                 395                 400 


Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala Trp Tyr Gln Gln Lys 
                405                 410                 415     


Pro Gly Lys Ala Pro Lys Leu Leu Ile His Ser Gly Ser Ser Leu Glu 
            420                 425                 430         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
        435                 440                 445             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 
    450                 455                 460                 


Cys Gln Gln His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys 
465                 470                 475                 480 


Val Glu Ile Lys Arg 
                485 


<210>  43
<211>  2193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA 01072 Anti PSMA scFv x Anti CD3 scFv

<400>  43
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatat ttcaaccctt ataatgatta cacacgctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatctgac      300

ggctactacg acgctatgga ctactggggg caagggacca cggtcaccgt ctcctcgggt      360

ggtggaggta gtggtggagg cggatctggc ggcggcggtt caggaggtgg tggatccgac      420

atccagatga cccagtctcc ttcctccctg tctgcatctg taggagacag agtcaccatc      480

acttgccggg ccagtaagag tattagtaag tacttggcct ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ccattctggc tccagtttgg aaagtggggt cccatcaagg      600

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat      660

gattttgcaa cttattactg ccaacagcat attgaatatc cttggacgtt cggccaaggg      720

accaaggtgg aaatcaaaga gcccaaatct tctgacaaaa ctcacacatg cccaccgtgc      780

ccagcacctc cagccgctgc accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      840

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      900

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaatggcaa ggaatacaag tgcgcggtct ccaacaaagc cctcccagcc     1080

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1140

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1200

ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1320

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggcgg cgggggatcc     1440

ccgtcacaag tacaactcgt tcaaagtggc gcagaagtaa agaagccagg cgccagtgtt     1500

aaggtgagct gcaaggcaag cgggtacacc ttcacccggt ctacaatgca ctgggtaaga     1560

caagcaccag ggcaaggact cgaatggatt ggttacatca acccttcctc tgcatacacc     1620

aactacgctc aaaagttcca gggccgcgtt actttgacag cggataaatc tacatccacg     1680

gcctatatgg aactgtcaag cctcaggagc gaggacacag cggtatatta ctgtgcatct     1740

ccccaggtcc attatgacta caacgggttt ccgtactggg gacaaggaac tctggttaca     1800

gtcagtagcg gtggtggagg tagtggtgga ggcggatctg gcggcggcgg ttcaggaggt     1860

ggtggatccg atatccagat gacccaaagt ccgagctcgt tgagtgcaag tgtaggagac     1920

cgcgtaacga ttacttgcag agcttcaagt tccgtatcct acatgaattg gtatcagcaa     1980

aagcctggaa aagcccctaa gcgctggata tacgattcaa gtaagttggc ttctggcgtc     2040

ccatcacggt tttctggttc aggttccggt acagatttta cgctgacaat cagctctctc     2100

caaccggaag atttcgcaac ctattactgt caacaatggt caagaaatcc gccgacattc     2160

gggcagggaa caaaagtcga gataaaaagg tca                                  2193


<210>  44
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 01072 Anti PSMA scFv x Anti CD3 scFv

<400>  44

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile His Ser Gly Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Pro Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
                485                 490                 495     


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            500                 505                 510         


Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        515                 520                 525             


Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Ala Gln 
    530                 535                 540                 


Lys Phe Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr 
545                 550                 555                 560 


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                565                 570                 575     


Tyr Cys Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
            580                 585                 590         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
    610                 615                 620                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
625                 630                 635                 640 


Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn 
                645                 650                 655     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp 
            660                 665                 670         


Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        675                 680                 685             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    690                 695                 700                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe 
705                 710                 715                 720 


Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ser 
                725                 730     


<210>  45
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti TA scFv x Fc Knob (Chain 1)

<400>  45
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca cagtgtttta tacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      300

cctccgacca ctttcggcgg agggaccaag gtggagatca aaggtggagg cggttcaggc      360

ggaggtggat ccggcggtgg cggctccggt ggcggcggat ctgaggtgca gctgttggag      420

tctgggggag gcttggtaca gcctgggggg tccctgagac tctcctgtgc agcctctgga      480

ttcaccttta gcagctatgg catgagctgg gtccgccagg ctccagggaa ggggctggag      540

ggggtctcag ctattagtgg tagtggtggt agcacatact acgcagactc cgtgaagggc      600

cggttcacca tctccagaga caattccaag aacacgctgt atctgcaaat gaacagcctg      660

agagccgagg acacggccgt atattactgt gcgaaagaaa agttacgata ttttgactgg      720

ttatccgatg cttttgatat ctggggccaa gggacaatgg tcaccgtctc ctcgagtgag      780

cccaaatctt ctgacaaaac tcacacatgc ccaccgtgcc cagcacctcc agccgctgca      840

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      900

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      960

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1020

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1080

gaatacaagt gcgcggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1140

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1200

ctgaccaaga accaggtcag cctgtggtgc ctggtcaaag gcttctatcc aagcgacatc     1260

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1320

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1380

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1440

cagaagagcc tctccctgtc tccgggtaaa                                      1470


<210>  46
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti TA scFv x Fc Knob (Chain 1)

<400>  46

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Gly Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp 
225                 230                 235                 240 


Leu Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
                245                 250                 255     


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro 
        275                 280                 285             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
305                 310                 315                 320 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                325                 330                 335     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            340                 345                 350         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn 
        355                 360                 365             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    370                 375                 380                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
385                 390                 395                 400 


Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 
                405                 410                 415     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            420                 425                 430         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        435                 440                 445             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    450                 455                 460                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
465                 470                 475                 480 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490 


<210>  47
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti TA scFv x Fc Hole x Anti CD3 scFv (Chain 2)

<400>  47
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca cagtgtttta tacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      300

cctccgacca ctttcggcgg agggaccaag gtggagatca aaggtggagg cggttcaggc      360

ggaggtggat ccggcggtgg cggctccggt ggcggcggat ctgaggtgca gctgttggag      420

tctgggggag gcttggtaca gcctgggggg tccctgagac tctcctgtgc agcctctgga      480

ttcaccttta gcagctatgg catgagctgg gtccgccagg ctccagggaa ggggctggag      540

ggggtctcag ctattagtgg tagtggtggt agcacatact acgcagactc cgtgaagggc      600

cggttcacca tctccagaga caattccaag aacacgctgt atctgcaaat gaacagcctg      660

agagccgagg acacggccgt atattactgt gcgaaagaaa agttacgata ttttgactgg      720

ttatccgatg cttttgatat ctggggccaa gggacaattg tcaccgtctc ctcgagtgag      780

cccaaatctt ctgacaaaac tcacacatgc ccaccgtgcc cagcacctcc agccgctgca      840

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      900

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      960

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1020

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1080

gaatacaagt gcgcggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1140

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1200

ctgaccaaga accaggtcag cctgtcttgc gctgtcaaag gcttctatcc aagcgacatc     1260

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1320

ctggactccg acggctcctt cttcctcgtt agcaagctca ccgtggacaa gagcaggtgg     1380

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccgtttcacg     1440

cagaagagcc tctccctgtc tccgggcggc gggggatccc cgtcacaagt acaactcgtt     1500

caaagtggcg cagaagtaaa gaagccaggc gccagtgtta aggtgagctg caaggcaagc     1560

gggtacacct tcacccggtc tacaatgcac tgggtaagac aagcaccagg gcaaggactc     1620

gaatggattg gttacatcaa cccttcctct gcatacacca actacgctca aaagttccag     1680

ggccgcgtta ctttgacagc ggataaatct acatccacgg cctatatgga actgtcaagc     1740

ctcaggagcg aggacacagc ggtatattac tgtgcatctc cccaggtcca ttatgactac     1800

aacgggtttc cgtactgggg acaaggaact ctggttacag tcagtagcgg tggtggaggt     1860

agtggtggag gcggatctgg cggcggcggt tcaggaggtg gtggatccga tgtccagctt     1920

acccaaagtc cgagcacgtt gagtgcaagt gtaggagacc gcgtaacgat tacttgctct     1980

gcttcaagtt ccgtatccta catgaattgg tatcagcaaa agcctggaaa agcccctaag     2040

cgctggatat acgattcaag taagttggct tctggcgtcc cagcacggtt ttctggttca     2100

ggttccggta cagaatatac gctgacaatc agctctctcc aaccggatga tttcgcaacc     2160

tattactgtc aacaatggtc aagaaatccg ccgacattcg ggcagggaac aaaagtcgag     2220

gtaaaaaggt ca                                                         2232


<210>  48
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti TA scFv x Fc Hole x Anti CD3 scFv (Chain 2)

<400>  48

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Gly Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp 
225                 230                 235                 240 


Leu Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Ile Val Thr Val 
                245                 250                 255     


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro 
        275                 280                 285             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
305                 310                 315                 320 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                325                 330                 335     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            340                 345                 350         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn 
        355                 360                 365             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    370                 375                 380                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
385                 390                 395                 400 


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
                405                 410                 415     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            420                 425                 430         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        435                 440                 445             


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    450                 455                 460                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr 
465                 470                 475                 480 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Pro Ser Gln 
                485                 490                 495     


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
            500                 505                 510         


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr 
        515                 520                 525             


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Ala Gln Lys Phe Gln 
545                 550                 555                 560 


Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
                565                 570                 575     


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
            580                 585                 590         


Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu 
625                 630                 635                 640 


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                645                 650                 655     


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
            660                 665                 670         


Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys 
        675                 680                 685             


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    690                 695                 700                 


Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
705                 710                 715                 720 


Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gln Gly 
                725                 730                 735     


Thr Lys Val Glu Val Lys Arg Ser 
            740                 


<210>  49
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti TA scFv x Fc Hole x Anti CD3 scFv (Chain 2)

<400>  49
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca cagtgtttta tacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      300

cctccgacca ctttcggcgg agggaccaag gtggagatca aaggtggagg cggttcaggc      360

ggaggtggat ccggcggtgg cggctccggt ggcggcggat ctgaggtgca gctgttggag      420

tctgggggag gcttggtaca gcctgggggg tccctgagac tctcctgtgc agcctctgga      480

ttcaccttta gcagctatgg catgagctgg gtccgccagg ctccagggaa ggggctggag      540

ggggtctcag ctattagtgg tagtggtggt agcacatact acgcagactc cgtgaagggc      600

cggttcacca tctccagaga caattccaag aacacgctgt atctgcaaat gaacagcctg      660

agagccgagg acacggccgt atattactgt gcgaaagaaa agttacgata ttttgactgg      720

ttatccgatg cttttgatat ctggggccaa gggacaatgg tcaccgtctc ctcgagtgag      780

cccaaatctt ctgacaaaac tcacacatgc ccaccgtgcc cagcacctcc agccgctgca      840

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      900

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      960

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1020

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1080

gaatacaagt gcgcggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1140

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1200

ctgaccaaga accaggtcag cctgtcttgc gctgtcaaag gcttctatcc aagcgacatc     1260

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1320

ctggactccg acggctcctt cttcctcgtt agcaagctca ccgtggacaa gagcaggtgg     1380

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccgtttcacg     1440

cagaagagcc tctccctgtc tccgggcggc gggggatccc cgtcacaagt acaactcgtt     1500

caaagtggcg cagaagtaaa gaagccaggc gccagtgtta aggtgagctg caaggcaagc     1560

gggtacacct tcacccggtc tacaatgcac tgggtaagac aagcaccagg gcaaggactc     1620

gaatggattg gttacatcaa cccttcctct gcatacacca actacaatca aaagttccag     1680

ggccgcgtta ctttgacagc ggataaatct acatccacgg cctatatgga actgtcaagc     1740

ctcaggagcg aggacacagc ggtatattac tgtgcatctc cccaggtcca ttatgactac     1800

aacgggtttc cgtactgggg acaaggaact ctggttacag tcagtagcgg tggtggaggt     1860

agtggtggag gcggatctgg cggcggcggt tcaggaggtg gtggatccga tgtccagctt     1920

acccaaagtc cgagcacgtt gagtgcaagt gtaggagacc gcgtaacgat tacttgctct     1980

gcttcaagtt ccgtatccta catgaattgg tatcagcaaa agcctggaaa agcccctaag     2040

cgctggatat acgattcaag taagttggct tctggcgtcc cagcacggtt ttctggttca     2100

ggttccggta cagaatatac gctgacaatc agctctctcc aaccggatga tttcgcaacc     2160

tattactgtc aacaatggtc aagaaatccg ccgacattcg ggcagggaac aaaagtcgag     2220

gtaaaaaggt ca                                                         2232


<210>  50
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti TA scFv x Fc Hole x Anti CD3 scFv (Chain 2)

<400>  50

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Gly Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp 
225                 230                 235                 240 


Leu Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
                245                 250                 255     


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro 
        275                 280                 285             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
305                 310                 315                 320 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                325                 330                 335     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            340                 345                 350         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn 
        355                 360                 365             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    370                 375                 380                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
385                 390                 395                 400 


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
                405                 410                 415     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            420                 425                 430         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        435                 440                 445             


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    450                 455                 460                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr 
465                 470                 475                 480 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Pro Ser Gln 
                485                 490                 495     


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
            500                 505                 510         


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr 
        515                 520                 525             


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Gln 
545                 550                 555                 560 


Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
                565                 570                 575     


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
            580                 585                 590         


Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu 
625                 630                 635                 640 


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                645                 650                 655     


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
            660                 665                 670         


Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys 
        675                 680                 685             


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    690                 695                 700                 


Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
705                 710                 715                 720 


Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gln Gly 
                725                 730                 735     


Thr Lys Val Glu Val Lys Arg Ser 
            740                 


<210>  51
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti TA scFv x Fc Hole x Anti CD3 scFv (Chain 2)

<400>  51
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca cagtgtttta tacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      300

cctccgacca ctttcggcgg agggaccaag gtggagatca aaggtggagg cggttcaggc      360

ggaggtggat ccggcggtgg cggctccggt ggcggcggat ctgaggtgca gctgttggag      420

tctgggggag gcttggtaca gcctgggggg tccctgagac tctcctgtgc agcctctgga      480

ttcaccttta gcagctatgg catgagctgg gtccgccagg ctccagggaa ggggctggag      540

ggggtctcag ctattagtgg tagtggtggt agcacatact acgcagactc cgtgaagggc      600

cggttcacca tctccagaga caattccaag aacacgctgt atctgcaaat gaacagcctg      660

agagccgagg acacggccgt atattactgt gcgaaagaaa agttacgata ttttgactgg      720

ttatccgatg cttttgatat ctggggccaa gggacaattg tcaccgtctc ctcgagtgag      780

cccaaatctt ctgacaaaac tcacacatgc ccaccgtgcc cagcacctcc agccgctgca      840

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      900

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      960

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1020

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1080

gaatacaagt gcgcggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1140

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1200

ctgaccaaga accaggtcag cctgtcttgc gctgtcaaag gcttctatcc aagcgacatc     1260

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1320

ctggactccg acggctcctt cttcctcgtt agcaagctca ccgtggacaa gagcaggtgg     1380

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccgtttcacg     1440

cagaagagcc tctccctgtc tccgggcggc gggggatccc cgtcacaagt acaactcgtt     1500

caaagtggcg cagaagtaaa gaagccaggc gccagtgtta aggtgagctg caaggcaagc     1560

gggtacacct tcacccggtc tacaatgcac tgggtaagac aagcaccagg gcaaggactc     1620

gaatggattg gttacatcaa cccttcctct gcatacacca actacgctca aaagttccag     1680

ggccgcgtta ctttgacagc ggataaatct acatccacgg cctatatgga actgtcaagc     1740

ctcaggagcg aggacacagc ggtatattac tgtgcatctc cccaggtcca ttatgactac     1800

aacgggtttc cgtactgggg acaaggaact ctggttacag tcagtagcgg tggtggaggt     1860

agtggtggag gcggatctgg cggcggcggt tcaggaggtg gtggatccga tatccagatg     1920

acccaaagtc cgagctcgtt gagtgcaagt gtaggagacc gcgtaacgat tacttgcaga     1980

gcttcaagtt ccgtatccta catgaattgg tatcagcaaa agcctggaaa agcccctaag     2040

cgctggatat acgattcaag taagttggct tctggcgtcc catcacggtt ttctggttca     2100

ggttccggta cagattttac gctgacaatc agctctctcc aaccggaaga tttcgcaacc     2160

tattactgtc aacaatggtc aagaaatccg ccgacattcg ggcagggaac aaaagtcgag     2220

ataaaaaggt ca                                                         2232


<210>  52
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti TA scFv x Fc Hole x Anti CD3 scFv (Chain 2)

<400>  52

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Gly Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp 
225                 230                 235                 240 


Leu Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Ile Val Thr Val 
                245                 250                 255     


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro 
        275                 280                 285             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
305                 310                 315                 320 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                325                 330                 335     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            340                 345                 350         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn 
        355                 360                 365             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    370                 375                 380                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
385                 390                 395                 400 


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
                405                 410                 415     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            420                 425                 430         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        435                 440                 445             


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    450                 455                 460                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr 
465                 470                 475                 480 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Pro Ser Gln 
                485                 490                 495     


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
            500                 505                 510         


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr 
        515                 520                 525             


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Ala Gln Lys Phe Gln 
545                 550                 555                 560 


Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
                565                 570                 575     


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
            580                 585                 590         


Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
625                 630                 635                 640 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                645                 650                 655     


Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
            660                 665                 670         


Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys 
        675                 680                 685             


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    690                 695                 700                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
705                 710                 715                 720 


Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gln Gly 
                725                 730                 735     


Thr Lys Val Glu Ile Lys Arg Ser 
            740                 


<210>  53
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-PSMA scFv x Fc Knob (Chain 1)

<400>  53
gacatccaga tgactcaaag cccttcaacc ctgtccgcaa gtgtcgggga cagagttact       60

ataacgtgca gggcaagtaa gagtataagt aaatatctgg cctggtatca acagaaaccc      120

gggaaagccc ctaaactcct catacattca ggatctagcc ttgagtcagg tgttccgtca      180

agattctctg gttccggaag cgggaccgag ttcaccctga caatcagttc actccagcct      240

gacgacttcg ctacttacta ctgccagcag cacatagagt acccctggac attcggacaa      300

ggaacgaaag tcgaaatcaa gggtggtgga ggtagtggtg gaggcggatc tggcggcggc      360

ggttcaggag gtggtggatc ccaggtccag ctggtacagt ctggggctga ggtgaagaag      420

cctggggctt cagtgaaggt ctcctgcaag gcttctggat acacattcac tgactactac      480

atgcactggg tgcgacaggc ccctggacaa gggcttgagt ggatgggata ttttaatcct      540

tataatgatt atactagata cgcacagaag ttccagggca gagtcaccat gaccagggac      600

acgtctacca gcacagtgta catggagctg agcagcctga gatctgagga cacggccgtg      660

tattactgtg caagatcgga tggttactac gatgctatgg actactgggg tcaaggaacc      720

acagtcaccg tcgagcccaa atcttctgac aaaactcaca catgcccacc gtgcccagca      780

cctccagccg ctgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      840

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      900

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      960

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1020

tggctgaatg gcaaggaata caagtgcgcg gtctccaaca aagccctccc agcccccatc     1080

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1140

ccatcccggg atgagctgac caagaaccag gtcagcctgt ggtgcctggt caaaggcttc     1200

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1260

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1320

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1380

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gt                        1422


<210>  54
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-PSMA scFv x Fc Knob (Chain 1)

<400>  54

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln 
            180                 185                 190         


Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Thr Val Thr Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  55
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv x Fc Hole (Chain 2)

<400>  55
caagtacaac tcgttcaaag tggcgcagaa gtaaagaagc caggcgccag tgttaaggtg       60

agctgcaagg caagcgggta caccttcacc cggtctacaa tgcactgggt aagacaagca      120

ccagggcaag gactcgaatg gattggttac atcaaccctt cctctgcata caccaactac      180

gctcaaaagt tccagggccg cgttactttg acagcggata aatctacatc cacggcctat      240

atggaactgt caagcctcag gagcgaggac acagcggtat attactgtgc atctccccag      300

gtccattatg actacaacgg gtttccgtac tggggacaag gaactctggt tacagtcagt      360

agcggtggtg gaggtagtgg tggaggcgga tctggcggcg gcggttcagg aggtggtgga      420

tccgatatcc agatgaccca aagtccgagc tcgttgagtg caagtgtagg agaccgcgta      480

acgattactt gcagagcttc aagttccgta tcctacatga attggtatca gcaaaagcct      540

ggaaaagccc ctaagcgctg gatatacgat tcaagtaagt tggcttctgg cgtcccatca      600

cggttttctg gttcaggttc cggtacagat tttacgctga caatcagctc tctccaaccg      660

gaagatttcg caacctatta ctgtcaacaa tggtcaagaa atccgccgac attcgggcag      720

ggaacaaaag tcgagataaa agagcccaaa tcttctgaca aaactcacac atgcccaccg      780

tgcccagcac ctccagccgc tgcaccgtca gtcttcctct tccccccaaa acccaaggac      840

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      900

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      960

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1020

caccaggact ggctgaatgg caaggaatac aagtgcgcgg tctccaacaa agccctccca     1080

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1140

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgtc ttgcgctgtc     1200

aaaggcttct atccaagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1260

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct cgttagcaag     1320

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1380

gaggctctgc acaaccgttt cacgcagaag agcctctccc tgtctccggg t              1431


<210>  56
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv x Fc Hole (Chain 2)

<400>  56

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
            180                 185                 190         


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    290                 295                 300                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475         


<210>  57
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv x Fc Knob (Chain 1)

<400>  57
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatat ttcaaccctt ataatgatta cacacgctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatctgac      300

ggctactacg acgctatgga ctactggggg caagggacca cggtcaccgt ctcctcgggt      360

ggtggaggta gtggtggagg cggatctggc ggcggcggtt caggaggtgg tggatccgac      420

atccagatga cccagtctcc ttcctccctg tctgcatctg taggagacag agtcaccatc      480

acttgccggg ccagtaagag tattagtaag tacttggcct ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ccattctggc tccagtttgg aaagtggggt cccatcaagg      600

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat      660

gattttgcaa cttattactg ccaacagcat attgaatatc cttggacgtt cggccaaggg      720

accaaggtgg aaatcaaaga gcccaaatct tctgacaaaa ctcacacatg cccaccgtgc      780

ccagcacctc cagccgctgc accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      840

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      900

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaatggcaa ggaatacaag tgcgcggtct ccaacaaagc cctcccagcc     1080

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1140

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgtggtg cctggtcaaa     1200

ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1320

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggt                  1428


<210>  58
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv x Fc Knob (Chain 1)

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile His Ser Gly Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475     


<210>  59
<211>  3624
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv x Fc Hole x linker x Anti CD3 scFv (Chain 2)

<400>  59
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatat ttcaaccctt ataatgatta cacacgctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatctgac      300

ggctactacg acgctatgga ctactggggg caagggacca cggtcaccgt ctcctcgggt      360

ggtggaggta gtggtggagg cggatctggc ggcggcggtt caggaggtgg tggatccgac      420

atccagatga cccagtctcc ttcctccctg tctgcatctg taggagacag agtcaccatc      480

acttgccggg ccagtaagag tattagtaag tacttggcct ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ccattctggc tccagtttgg aaagtggggt cccatcaagg      600

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat      660

gattttgcaa cttattactg ccaacagcat attgaatatc cttggacgtt cggccaaggg      720

accaaggtgg aaatcaaaga gcccaaatct tctgacaaaa ctcacacatg cccaccgtgc      780

ccagcacctc cagccgctgc accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      840

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      900

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaatggcaa ggaatacaag tgcgcggtct ccaacaaagc cctcccagcc     1080

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1140

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgtcttg cgctgtcaaa     1200

ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcgt tagcaagctc     1320

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accgtttcac gcagaagagc ctctccctgt ctccgggcgg cgggggatcc     1440

ccgtcacaag tacaactcgt tcaaagtggc gcagaagtaa agaagccagg cgccagtgtt     1500

aaggtgagct gcaaggcaag cgggtacacc ttcacccggt ctacaatgca ctgggtaaga     1560

caagcaccag ggcaaggact cgaatggatt ggttacatca acccttcctc tgcatacacc     1620

aactacgctc aaaagttcca gggccgcgtt actttgacag cggataaatc tacatccacg     1680

gcctatatgg aactgtcaag cctcaggagc gaggacacag cggtatatta ctgtgcatct     1740

ccccaggtcc attatgacta caacgggttt ccgtactggg gacaaggaac tctggttaca     1800

gtcagtagcg gtggtggagg tagtggtgga ggcggatctg gcggcggcgg ttcaggaggt     1860

ggtggatccg atatccagat gacccaaagt ccgagctcgt tgagtgcaag tgtaggagac     1920

cgcgtaacga ttacttgcag agcttcaagt tccgtatcct acatgaattg gtatcagcaa     1980

aagcctggaa aagcccctaa gcgctggata tacgattcaa gtaagttggc ttctggcgtc     2040

ccatcacggt tttctggttc aggttccggt acagatttta cgctgacaat cagctctctc     2100

caaccggaag atttcgcaac ctattactgt caacaatggt caagaaatcc gccgacattc     2160

gggcagggaa caaaagtcga gataaaaagg tcacaagtac aactcgttca aagtggcgca     2220

gaagtaaaga agccaggcgc cagtgttaag gtgagctgca aggcaagcgg gtacaccttc     2280

acccggtcta caatgcactg ggtaagacaa gcaccagggc aaggactcga atggattggt     2340

tacatcaacc cttcctctgc atacaccaac tacgctcaaa agttccaggg ccgcgttact     2400

ttgacagcgg ataaatctac atccacggcc tatatggaac tgtcaagcct caggagcgag     2460

gacacagcgg tatattactg tgcatctccc caggtccatt atgactacaa cgggtttccg     2520

tactggggac aaggaactct ggttacagtc agtagcggtg gtggaggtag tggtggaggc     2580

ggatctggcg gcggcggttc aggaggtggt ggatccgata tccagatgac ccaaagtccg     2640

agctcgttga gtgcaagtgt aggagaccgc gtaacgatta cttgcagagc ttcaagttcc     2700

gtatcctaca tgaattggta tcagcaaaag cctggaaaag cccctaagcg ctggatatac     2760

gattcaagta agttggcttc tggcgtccca tcacggtttt ctggttcagg ttccggtaca     2820

gattttacgc tgacaatcag ctctctccaa ccggaagatt tcgcaaccta ttactgtcaa     2880

caatggtcaa gaaatccgcc gacattcggg cagggaacaa aagtcgagat aaaagagccc     2940

aaatcttctg acaaaactca cacatgccca ccgtgcccag cacctccagc cgctgcaccg     3000

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag     3060

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac     3120

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc     3180

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggaa     3240

tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     3300

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     3360

accaagaacc aggtcagcct gtcttgcgct gtcaaaggct tctatccaag cgacatcgcc     3420

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     3480

gactccgacg gctccttctt cctcgttagc aagctcaccg tggacaagag caggtggcag     3540

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaaccg tttcacgcag     3600

aagagcctct ccctgtctcc gggt                                            3624


<210>  60
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv x Fc Hole x linker x Anti CD3 scFv (Chain 2)

<400>  60

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile His Ser Gly Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Pro Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
                485                 490                 495     


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            500                 505                 510         


Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        515                 520                 525             


Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Ala Gln 
    530                 535                 540                 


Lys Phe Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr 
545                 550                 555                 560 


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                565                 570                 575     


Tyr Cys Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
            580                 585                 590         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
    610                 615                 620                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
625                 630                 635                 640 


Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn 
                645                 650                 655     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp 
            660                 665                 670         


Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        675                 680                 685             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    690                 695                 700                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe 
705                 710                 715                 720 


Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ser 
                725                 730     


<210>  61
<211>  2187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti PSMA x Fc Hole x Anti CD3 (Chain 2)

<400>  61
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatat ttcaaccctt ataatgatta cacacgctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatctgac      300

ggctactacg acgctatgga ctactggggg caagggacca cggtcaccgt ctcctcgggt      360

ggtggaggta gtggtggagg cggatctggc ggcggcggtt caggaggtgg tggatccgac      420

atccagatga cccagtctcc ttcctccctg tctgcatctg taggagacag agtcaccatc      480

acttgccggg ccagtaagag tattagtaag tacttggcct ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ccattctggc tccagtttgg aaagtggggt cccatcaagg      600

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat      660

gattttgcaa cttattactg ccaacagcat attgaatatc cttggacgtt cggccaaggg      720

accaaggtgg aaatcaaaga gcccaaatct tctgacaaaa ctcacacatg cccaccgtgc      780

ccagcacctc cagccgctgc accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      840

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      900

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaatggcaa ggaatacaag tgcgcggtct ccaacaaagc cctcccagcc     1080

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1140

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgtcttg cgctgtcaaa     1200

ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcgt tagcaagctc     1320

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accgtttcac gcagaagagc ctctccctgt ctccgggcgg cgggggatcc     1440

ccgtcagata tccagatgac ccaaagtccg agctcgttga gtgcaagtgt aggagaccgc     1500

gtaacgatta cttgcagagc ttcaagttcc gtatcctaca tgaattggta tcagcaaaag     1560

cctggaaaag cccctaagcg ctggatatac gattcaagta agttggcttc tggcgtccca     1620

tcacggtttt ctggttcagg ttccggtaca gattttacgc tgacaatcag ctctctccaa     1680

ccggaagatt tcgcaaccta ttactgtcaa caatggtcaa gaaatccgcc gacattcggg     1740

cagggaacaa aagtcgagat aaaaggcgga ggcggaagcg gaggtggggg ctccggaggc     1800

gggggaagcg gcggaggtgg ctctcaagta caactcgttc aaagtggcgc agaagtaaag     1860

aagccaggcg ccagtgttaa ggtgagctgc aaggcaagcg ggtacacctt cacccggtct     1920

acaatgcact gggtaagaca agcaccaggg caaggactcg aatggattgg ttacatcaac     1980

ccttcctctg catacaccaa ctacgctcaa aagttccagg gccgcgttac tttgacagcg     2040

gataaatcta catccacggc ctatatggaa ctgtcaagcc tcaggagcga ggacacagcg     2100

gtatattact gtgcatctcc ccaggtccat tatgactaca acgggtttcc gtactgggga     2160

caaggaactc tggttacagt cagtagc                                         2187


<210>  62
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti PSMA x Fc Hole x Anti CD3 (Chain 2)

<400>  62

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile His Ser Gly Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Pro Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
                485                 490                 495     


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser 
            500                 505                 510         


Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp 
        515                 520                 525             


Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    530                 535                 540                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
545                 550                 555                 560 


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro 
                565                 570                 575     


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            580                 585                 590         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
    610                 615                 620                 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
625                 630                 635                 640 


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
                645                 650                 655     


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Ala Gln Lys Phe 
            660                 665                 670         


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
        675                 680                 685             


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    690                 695                 700                 


Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
705                 710                 715                 720 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                725                 


<210>  63
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC01007  PAAdel Fc

<400>  63
tcctcggagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctcca       60

gccgctgcac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      120

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      180

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      240

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      300

aatggcaagg aatacaagtg cgcggtctcc aacaaagccc tcccagcccc catcgagaaa      360

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc      420

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatcca      480

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg      540

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag      600

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac      660

cactacacgc agaagagcct ctccctgtct ccgggt                                696


<210>  64
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC01007  PAAdel Fc

<400>  64

Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230         


<210>  65
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAAdel Fc

+ Knob

<400>  65
gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tccagccgct       60

gcaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      120

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      180

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      240

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      300

aaggaataca agtgcgcggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc      360

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat      420

gagctgacca agaaccaggt cagcctgtgg tgcctggtca aaggcttcta tccaagcgac      480

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      540

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg      600

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac      660

acgcagaaga gcctctccct gtctccg                                          687


<210>  66
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAAdel Fc

+ Knob

<400>  66

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro 
225                 


<210>  67
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAAdel Fc + Hole

<400>  67
gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tccagccgct       60

gcaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      120

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      180

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      240

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      300

aaggaataca agtgcgcggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc      360

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat      420

gagctgacca agaaccaggt cagcctgtct tgcgctgtca aaggcttcta tccaagcgac      480

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      540

gtgctggact ccgacggctc cttcttcctc gttagcaagc tcaccgtgga caagagcagg      600

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac      660

acgcagaaga gcctctccct gtctccgggt                                       690


<210>  68
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAAdel Fc + Hole

<400>  68

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly 
225                 230 


<210>  69
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv HCDR1

<400>  69
ggatacacct tcaccgacta ctat                                              24


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv HCDR1

<400>  70

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  71
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv HCDR2

<400>  71
ttcaaccctt ataatgatta caca                                              24


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv HCDR2

<400>  72

Phe Asn Pro Tyr Asn Asp Tyr Thr 
1               5               


<210>  73
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv HCDR3

<400>  73
gcgagatctg acggctacta cgacgctatg gactac                                 36


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv HCDR3

<400>  74

Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr 
1               5                   10          


<210>  75
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv LCDR1

<400>  75
aagagtatta gtaagtac                                                     18


<210>  76
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv LCDR2

<400>  76

Lys Ser Ile Ser Lys Tyr 
1               5       


<210>  77
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv LCDR2

<400>  77
tctggctcc                                                                9


<210>  78
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv LCDR2

<400>  78

Ser Gly Ser 
1           


<210>  79
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv LCDR3

<400>  79
caacagcata ttgaatatcc ttggacg                                           27


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv LCDR3

<400>  80

Gln Gln His Ile Glu Tyr Pro Trp Thr 
1               5                   


<210>  81
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv Heavy Chain

<400>  81
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatat ttcaaccctt ataatgatta cacacgctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatctgac      300

ggctactacg acgctatgga ctactggggg caagggacca cggtcaccgt ctcctcg         357


<210>  82
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv Heavy Chain

<400>  82

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  83
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv Light Chain

<400>  83
gacatccaga tgacccagtc tccttcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtaa gagtattagt aagtacttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatccattct ggctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag catattgaat atccttggac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210>  84
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv Light Chain

<400>  84

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  85
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv

<400>  85
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatat ttcaaccctt ataatgatta cacacgctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatctgac      300

ggctactacg acgctatgga ctactggggg caagggacca cggtcaccgt ctcctcggga      360

ggcggtggat caggcggtgg aggcagcgga ggaggtggct ccggtggcgg agggagcgac      420

atccagatga cccagtctcc ttcctccctg tctgcatctg taggagacag agtcaccatc      480

acttgccggg ccagtaagag tattagtaag tacttggcct ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ccattctggc tccagtttgg aaagtggggt cccatcaagg      600

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat      660

gattttgcaa cttattactg ccaacagcat attgaatatc cttggacgtt cggccaaggg      720

accaaggtgg aaatcaaa                                                    738


<210>  86
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti PSMA scFv

<400>  86

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile His Ser Gly Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  87
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv  HCDR1

<400>  87
gggtacacct tcacccggtc taca                                              24


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv  HCDR1

<400>  88

Gly Tyr Thr Phe Thr Arg Ser Thr 
1               5               


<210>  89
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv  HCDR2

<400>  89
atcaaccctt cctctgcata cacc                                              24


<210>  90
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv  HCDR2

<400>  90

Ile Asn Pro Ser Ser Ala Tyr Thr 
1               5               


<210>  91
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv  HCDR3

<400>  91
gcatctcccc aggtccatta tgactacaac gggtttccgt ac                          42


<210>  92
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv  HCDR3

<400>  92

Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
1               5                   10                  


<210>  93
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv  LCDR1

<400>  93
agttccgtat cctac                                                        15


<210>  94
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv  LCDR1

<400>  94

Ser Ser Val Ser Tyr 
1               5   


<210>  95
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv  LCDR2

<400>  95
gattcaagt                                                                9


<210>  96
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv  LCDR2

<400>  96

Asp Ser Ser 
1           


<210>  97
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv  LCDR3

<400>  97
caacaatggt caagaaatcc gccgaca                                           27


<210>  98
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv  LCDR3

<400>  98

Gln Gln Trp Ser Arg Asn Pro Pro Thr 
1               5                   


<210>  99
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv Heavy Chain

<400>  99
caagtacaac tcgttcaaag tggcgcagaa gtaaagaagc caggcgccag tgttaaggtg       60

agctgcaagg caagcgggta caccttcacc cggtctacaa tgcactgggt aagacaagca      120

ccagggcaag gactcgaatg gattggttac atcaaccctt cctctgcata caccaactac      180

gctcaaaagt tccagggccg cgttactttg acagcggata aatctacatc cacggcctat      240

atggaactgt caagcctcag gagcgaggac acagcggtat attactgtgc atctccccag      300

gtccattatg actacaacgg gtttccgtac tggggacaag gaactctggt tacagtcagt      360

agc                                                                    363


<210>  100
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv Heavy Chain

<400>  100

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  101
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL

<400>  101
gatatccaga tgacccaaag tccgagctcg ttgagtgcaa gtgtaggaga ccgcgtaacg       60

attacttgca gagcttcaag ttccgtatcc tacatgaatt ggtatcagca aaagcctgga      120

aaagccccta agcgctggat atacgattca agtaagttgg cttctggcgt cccatcacgg      180

ttttctggtt caggttccgg tacagatttt acgctgacaa tcagctctct ccaaccggaa      240

gatttcgcaa cctattactg tcaacaatgg tcaagaaatc cgccgacatt cgggcaggga      300

acaaaagtcg agataaaa                                                    318


<210>  102
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  102

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  103
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  103
caagtacaac tcgttcaaag tggcgcagaa gtaaagaagc caggcgccag tgttaaggtg       60

agctgcaagg caagcgggta caccttcacc cggtctacaa tgcactgggt aagacaagca      120

ccagggcaag gactcgaatg gattggttac atcaaccctt cctctgcata caccaactac      180

gctcaaaagt tccagggccg cgttactttg acagcggata aatctacatc cacggcctat      240

atggaactgt caagcctcag gagcgaggac acagcggtat attactgtgc atctccccag      300

gtccattatg actacaacgg gtttccgtac tggggacaag gaactctggt tacagtcagt      360

agcggcggag gcggaagcgg aggtgggggc tccggaggcg ggggaagcgg cggaggtggc      420

tctgatatcc agatgaccca aagtccgagc tcgttgagtg caagtgtagg agaccgcgta      480

acgattactt gcagagcttc aagttccgta tcctacatga attggtatca gcaaaagcct      540

ggaaaagccc ctaagcgctg gatatacgat tcaagtaagt tggcttctgg cgtcccatca      600

cggttttctg gttcaggttc cggtacagat tttacgctga caatcagctc tctccaaccg      660

gaagatttcg caacctatta ctgtcaacaa tggtcaagaa atccgccgac attcgggcag      720

ggaacaaaag tcgagataaa a                                                741


<210>  104
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  104

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
            180                 185                 190         


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  105
<211>  2193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti PSMA x Fc Knob x Anti CD3 scFv (Chain 1)

<400>  105
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatat ttcaaccctt ataatgatta cacacgctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatctgac      300

ggctactacg acgctatgga ctactggggg caagggacca cggtcaccgt ctcctcggga      360

ggcggtggat caggcggtgg aggcagcgga ggaggtggct ccggtggcgg agggagcgac      420

atccagatga cccagtctcc ttcctccctg tctgcatctg taggagacag agtcaccatc      480

acttgccggg ccagtaagag tattagtaag tacttggcct ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ccattctggc tccagtttgg aaagtggggt cccatcaagg      600

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat      660

gattttgcaa cttattactg ccaacagcat attgaatatc cttggacgtt cggccaaggg      720

accaaggtgg aaatcaaaga gcccaaatct tctgacaaaa ctcacacatg cccaccgtgc      780

ccagcacctc cagccgctgc accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      840

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      900

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaatggcaa ggaatacaag tgcgcggtct ccaacaaagc cctcccagcc     1080

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1140

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgtggtg cctggtcaaa     1200

ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1320

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggcgg cgggggatcc     1440

ccgtcacaag tacaactcgt tcaaagtggc gcagaagtaa agaagccagg cgccagtgtt     1500

aaggtgagct gcaaggcaag cgggtacacc ttcacccggt ctacaatgca ctgggtaaga     1560

caagcaccag ggcaaggact cgaatggatt ggttacatca acccttcctc tgcatacacc     1620

aactacgctc aaaagttcca gggccgcgtt actttgacag cggataaatc tacatccacg     1680

gcctatatgg aactgtcaag cctcaggagc gaggacacag cggtatatta ctgtgcatct     1740

ccccaggtcc attatgacta caacgggttt ccgtactggg gacaaggaac tctggttaca     1800

gtcagtagcg gcggaggcgg aagcggaggt gggggctccg gaggcggggg aagcggcgga     1860

ggtggctctg atatccagat gacccaaagt ccgagctcgt tgagtgcaag tgtaggagac     1920

cgcgtaacga ttacttgcag agcttcaagt tccgtatcct acatgaattg gtatcagcaa     1980

aagcctggaa aagcccctaa gcgctggata tacgattcaa gtaagttggc ttctggcgtc     2040

ccatcacggt tttctggttc aggttccggt acagatttta cgctgacaat cagctctctc     2100

caaccggaag atttcgcaac ctattactgt caacaatggt caagaaatcc gccgacattc     2160

gggcagggaa caaaagtcga gataaaaagg tca                                  2193


<210>  106
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti PSMA x Fc Knob x Anti CD3 scFv (Chain 1)

<400>  106

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile His Ser Gly Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Pro Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
                485                 490                 495     


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            500                 505                 510         


Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        515                 520                 525             


Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Ala Gln 
    530                 535                 540                 


Lys Phe Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr 
545                 550                 555                 560 


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                565                 570                 575     


Tyr Cys Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
            580                 585                 590         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
    610                 615                 620                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
625                 630                 635                 640 


Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn 
                645                 650                 655     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp 
            660                 665                 670         


Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        675                 680                 685             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    690                 695                 700                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe 
705                 710                 715                 720 


Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ser 
                725                 730     


<210>  107
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti PSMA x Fc Hole

(Chain 2)

<400>  107
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatat ttcaaccctt ataatgatta cacacgctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatctgac      300

ggctactacg acgctatgga ctactggggg caagggacca cggtcaccgt ctcctcgggt      360

ggtggaggta gtggtggagg cggatctggc ggcggcggtt caggaggtgg tggatccgac      420

atccagatga cccagtctcc ttcctccctg tctgcatctg taggagacag agtcaccatc      480

acttgccggg ccagtaagag tattagtaag tacttggcct ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ccattctggc tccagtttgg aaagtggggt cccatcaagg      600

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat      660

gattttgcaa cttattactg ccaacagcat attgaatatc cttggacgtt cggccaaggg      720

accaaggtgg aaatcaaaga gcccaaatct tctgacaaaa ctcacacatg cccaccgtgc      780

ccagcacctc cagccgctgc accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      840

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      900

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaatggcaa ggaatacaag tgcgcggtct ccaacaaagc cctcccagcc     1080

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1140

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgtcttg cgctgtcaaa     1200

ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcgt tagcaagctc     1320

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggt                  1428


<210>  108
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti PSMA x Fc Hole

(Chain 2)

<400>  108

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile His Ser Gly Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475     


<210>  109
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv

<400>  109
gatatccaga tgacccaaag tccgagctcg ttgagtgcaa gtgtaggaga ccgcgtaacg       60

attacttgca gagcttcaag ttccgtatcc tacatgaatt ggtatcagca aaagcctgga      120

aaagccccta agcgctggat atacgattca agtaagttgg cttctggcgt cccatcacgg      180

ttttctggtt caggttccgg tacagatttt acgctgacaa tcagctctct ccaaccggaa      240

gatttcgcaa cctattactg tcaacaatgg tcaagaaatc cgccgacatt cgggcaggga      300

acaaaagtcg agataaaagg cggaggcgga agcggaggtg ggggctccgg aggcggggga      360

agcggcggag gtggctctca agtacaactc gttcaaagtg gcgcagaagt aaagaagcca      420

ggcgccagtg ttaaggtgag ctgcaaggca agcgggtaca ccttcacccg gtctacaatg      480

cactgggtaa gacaagcacc agggcaagga ctcgaatgga ttggttacat caacccttcc      540

tctgcataca ccaactacgc tcaaaagttc cagggccgcg ttactttgac agcggataaa      600

tctacatcca cggcctatat ggaactgtca agcctcagga gcgaggacac agcggtatat      660

tactgtgcat ctccccaggt ccattatgac tacaacgggt ttccgtactg gggacaagga      720

actctggtta cagtcagtag c                                                741


<210>  110
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv

<400>  110

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
    130                 135                 140                 


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met 
145                 150                 155                 160 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
                165                 170                 175     


Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Ala Gln Lys Phe Gln Gly 
            180                 185                 190         


Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 
        195                 200                 205             


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
    210                 215                 220                 


Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  111
<211>  2187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti PSMA x Fc Knob x Anti CD3 scFv

(Chain 1)

<400>  111
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatat ttcaaccctt ataatgatta cacacgctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatctgac      300

ggctactacg acgctatgga ctactggggg caagggacca cggtcaccgt ctcctcggga      360

ggcggtggat caggcggtgg aggcagcgga ggaggtggct ccggtggcgg agggagcgac      420

atccagatga cccagtctcc ttcctccctg tctgcatctg taggagacag agtcaccatc      480

acttgccggg ccagtaagag tattagtaag tacttggcct ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ccattctggc tccagtttgg aaagtggggt cccatcaagg      600

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat      660

gattttgcaa cttattactg ccaacagcat attgaatatc cttggacgtt cggccaaggg      720

accaaggtgg aaatcaaaga gcccaaatct tctgacaaaa ctcacacatg cccaccgtgc      780

ccagcacctc cagccgctgc accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      840

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      900

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaatggcaa ggaatacaag tgcgcggtct ccaacaaagc cctcccagcc     1080

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1140

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgtggtg cctggtcaaa     1200

ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1320

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggcgg cgggggatcc     1440

ccgtcagata tccagatgac ccaaagtccg agctcgttga gtgcaagtgt aggagaccgc     1500

gtaacgatta cttgcagagc ttcaagttcc gtatcctaca tgaattggta tcagcaaaag     1560

cctggaaaag cccctaagcg ctggatatac gattcaagta agttggcttc tggcgtccca     1620

tcacggtttt ctggttcagg ttccggtaca gattttacgc tgacaatcag ctctctccaa     1680

ccggaagatt tcgcaaccta ttactgtcaa caatggtcaa gaaatccgcc gacattcggg     1740

cagggaacaa aagtcgagat aaaaggcgga ggcggaagcg gaggtggggg ctccggaggc     1800

gggggaagcg gcggaggtgg ctctcaagta caactcgttc aaagtggcgc agaagtaaag     1860

aagccaggcg ccagtgttaa ggtgagctgc aaggcaagcg ggtacacctt cacccggtct     1920

acaatgcact gggtaagaca agcaccaggg caaggactcg aatggattgg ttacatcaac     1980

ccttcctctg catacaccaa ctacgctcaa aagttccagg gccgcgttac tttgacagcg     2040

gataaatcta catccacggc ctatatggaa ctgtcaagcc tcaggagcga ggacacagcg     2100

gtatattact gtgcatctcc ccaggtccat tatgactaca acgggtttcc gtactgggga     2160

caaggaactc tggttacagt cagtagc                                         2187


<210>  112
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti PSMA x Fc Knob x Anti CD3 scFv

(Chain 1)

<400>  112

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile His Ser Gly Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Pro Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
                485                 490                 495     


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser 
            500                 505                 510         


Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp 
        515                 520                 525             


Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    530                 535                 540                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
545                 550                 555                 560 


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro 
                565                 570                 575     


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            580                 585                 590         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
    610                 615                 620                 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
625                 630                 635                 640 


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
                645                 650                 655     


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Ala Gln Lys Phe 
            660                 665                 670         


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
        675                 680                 685             


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    690                 695                 700                 


Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
705                 710                 715                 720 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                725                 


<210>  113
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA01012  VH domain

<400>  113
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcttc agtgaaggtc       60

tcctgcaagg cttctggata cacattcact gactactaca tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatat tttaatcctt ataatgatta tactagatac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtctatcag cacagcctac      240

atggagctga gcagcctgag atctgacgac acggccgtgt attactgtgc aagatcggat      300

ggttactacg atgctatgga ctactggggt caaggaacca cagtcaccgt ctcctcg         357


<210>  114
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01012  VH domain

<400>  114

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  115
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA01012  VL domain

<400>  115
gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      120

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      300

gggaccaagg tggaaatcaa acga                                             324


<210>  116
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01012  VL domain

<400>  116

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  117
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  107-1A4 VH domain

<400>  117
gagatccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact gactactaca tgcactgggt gaagcagaac      120

aatggagaga gccttgagtg gattggatat tttaatcctt ataatgatta tactagatac      180

aaccagaatt tcaatggcaa ggccacattg actgtagaca agtcctccag cacagcctac      240

atgcagctca acagcctgac atctgaggac tctgcattct attactgtgc aagatcggat      300

ggttactacg atgctatgga ctactggggt caaggaacct cagtcaccgt ctcctcg         357


<210>  118
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  107-1A4 VH domain

<400>  118

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Asn Asn Gly Glu Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Asn Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  119
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  107-1A4 VL domain

<400>  119
gatgtccaga taacccagtc tccatcttat cttgctgcat ctcctggaga aaccattact       60

attaattgca gggcaagtaa gagcattagc aaatatttag cctggtatca agagaaacct      120

gggaaagcta ataagctact tatccattct ggatccactt tgcaatctgg aataccatca      180

aggttcagtg gcagtggatc tggtacagat ttcactctca ccatcagtag cctggagcct      240

gaagattttg caatgtatta ctgtcaacag catattgaat acccgtggac gttcggtggt      300

ggcaccaaac tggaaattaa acgggcc                                          327


<210>  120
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  107-1A4 VL domain

<400>  120

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Ala Asn Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 


<210>  121

<400>  121
000

<210>  122
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS-7 VH domain

<400>  122

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr 
        115 


<210>  123

<400>  123
000

<210>  124
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS-7 VL domain

<400>  124

Gln Val Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Phe Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Thr Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Arg 
            100                 105         


<210>  125

<400>  125
000

<210>  126
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRA222 VH domain (TSC266 CD3 VH domain)

<400>  126

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  127

<400>  127
000

<210>  128
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRA222VL domain (TSC266 CD3 VL domain)

<400>  128

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr 
            100                 105     


<210>  129

<400>  129
000

<210>  130
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC456 VH domain

<400>  130

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  131

<400>  131
000

<210>  132
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC456 VL domain

<400>  132

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  133

<400>  133
000

<210>  134
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS7H14 VH domain

<400>  134

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  135

<400>  135
000

<210>  136
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS7H14 VL domain

<400>  136

Asp Val Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Met Pro Pro Thr Phe Gly Gln 
                85                  90                  95      


Gly Thr Lys Val Glu Val Lys 
            100             


<210>  137

<400>  137
000

<210>  138
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS7H15 VH domain

<400>  138

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Arg 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  139

<400>  139
000

<210>  140
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS7H15 VL domain

<400>  140

Asp Val Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105     


<210>  141

<400>  141
000

<210>  142
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS7H16 VH domain

<400>  142

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  143

<400>  143
000

<210>  144
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS7H16 VL domain

<400>  144

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  145
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sss(s)-hIgG1 hinge

<400>  145

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  146
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  csc(s)-hIgG1 hinge

<400>  146

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  147
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ssc(s)-hIgG1 hinge

<400>  147

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  148
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scc(s)-hIgG1 hinge

<400>  148

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  149
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  css(s)-hIgG1 hinge

<400>  149

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  150
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scs(s)-hIgG1 hinge

<400>  150

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  151
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ccc(s)-hIgG1 hinge

<400>  151

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  152
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ccc(p)-hIgG1 hinge

<400>  152

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  153
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sss(p)-hIgG1 hinge

<400>  153

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  154
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  csc(p)-hIgG1 hinge

<400>  154

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  155
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ssc(p)-hIgG1 hinge

<400>  155

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  156
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scc(p)-hIgG1 hinge

<400>  156

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  157
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  css(p)-hIgG1 hinge

<400>  157

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  158
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scs(p)-hIgG1 hinge

<400>  158

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  159
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Scppcp

<400>  159

Ser Cys Pro Pro Cys Pro 
1               5       


<210>  160
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STD1

<400>  160

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Ser 
            20  


<210>  161
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STD2

<400>  161

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Asn Ser 
        35              


<210>  162
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1

<400>  162

Asn Ser 
1       


<210>  163
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2

<400>  163

Gly Gly Gly Gly Ser Gly Asn Ser 
1               5               


<210>  164
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3

<400>  164

Asn Tyr Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10  


<210>  165
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H4

<400>  165

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10              


<210>  166
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H5

<400>  166

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10                  15  


<210>  167
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H6

<400>  167

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Asn Ser 
        


<210>  168
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H7

<400>  168

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  169
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)3

<400>  169

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  170
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H105

<400>  170

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  171
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)4

<400>  171

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  172
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H94

<400>  172

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  173
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H111

<400>  173

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Pro Gly Ser 
            


<210>  174
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H114

<400>  174

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro 
1               5                   10                  15      


Ser 
    


<210>  175
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4S

<400>  175

Gly Gly Gly Gly Ser 
1               5   


<210>  176

<400>  176
000

<210>  177
<211>  2187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti PSMA x Fc Knob x Anti CD3 scFv (Chain 1)


<400>  177
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatat ttcaaccctt ataatgatta cacacgctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatctgac      300

ggctactacg acgctatgga ctactggggg caagggacca cggtcaccgt ctcctcggga      360

ggcggtggat caggcggtgg aggcagcgga ggaggtggct ccggtggcgg agggagcgac      420

atccagatga cccagtctcc ttcctccctg tctgcatctg taggagacag agtcaccatc      480

acttgccggg ccagtaagag tattagtaag tacttggcct ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ccattctggc tccagtttgg aaagtggggt cccatcaagg      600

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat      660

gattttgcaa cttattactg ccaacagcat attgaatatc cttggacgtt cggccaaggg      720

accaaggtgg aaatcaaaga gcccaaatct tctgacaaaa ctcacacatg cccaccgtgc      780

ccagcacctc cagccgctgc accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      840

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      900

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaatggcaa ggaatacaag tgcgcggtct ccaacaaagc cctcccagcc     1080

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1140

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgtggtg cctggtcaaa     1200

ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1320

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggcgg cgggggatcc     1440

ccgtcacaag tacaactcgt tcaaagtggc gcagaagtaa agaagccagg cgccagtgtt     1500

aaggtgagct gcaaggcaag cgggtacacc ttcacccggt ctacaatgca ctgggtaaga     1560

caagcaccag ggcaaggact cgaatggatt ggttacatca acccttcctc tgcatacacc     1620

aactacgctc aaaagttcca gggccgcgtt actttgacag cggataaatc tacatccacg     1680

gcctatatgg aactgtcaag cctcaggagc gaggacacag cggtatatta ctgtgcatct     1740

ccccaggtcc attatgacta caacgggttt ccgtactggg gacaaggaac tctggttaca     1800

gtcagtagcg gcggaggcgg aagcggaggt gggggctccg gaggcggggg aagcggcgga     1860

ggtggctctg atatccagat gacccaaagt ccgagctcgt tgagtgcaag tgtaggagac     1920

cgcgtaacga ttacttgcag agcttcaagt tccgtatcct acatgaattg gtatcagcaa     1980

aagcctggaa aagcccctaa gcgctggata tacgattcaa gtaagttggc ttctggcgtc     2040

ccatcacggt tttctggttc aggttccggt acagatttta cgctgacaat cagctctctc     2100

caaccggaag atttcgcaac ctattactgt caacaatggt caagaaatcc gccgacattc     2160

gggcagggaa caaaagtcga gataaaa                                         2187


<210>  178
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti PSMA x Fc Knob x Anti CD3 scFv (Chain 1)

<400>  178

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile His Ser Gly Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Pro Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
                485                 490                 495     


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            500                 505                 510         


Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        515                 520                 525             


Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Ala Gln 
    530                 535                 540                 


Lys Phe Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr 
545                 550                 555                 560 


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                565                 570                 575     


Tyr Cys Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
            580                 585                 590         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
    610                 615                 620                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
625                 630                 635                 640 


Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn 
                645                 650                 655     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp 
            660                 665                 670         


Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        675                 680                 685             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    690                 695                 700                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe 
705                 710                 715                 720 


Gly Gln Gly Thr Lys Val Glu Ile Lys 
                725                 


<210>  179
<211>  2820
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mIgG Fc- human PSMA ECD

<400>  179
tcgagtgagc ccagagggcc cacaatcaag ccctgtcctc catgcaaatg cccggctcca       60

aatgctgcag gtggtccatc cgtcttcatc ttccctccaa agatcaagga tgtactcatg      120

atctccctga gccccatagt cacatgtgtg gtggtggatg tgagcgagga cgacccagat      180

gtccagatca gctggtttgt gaacaacgtg gaagtacaca cagctcagac acaaacccat      240

agagaggatt acaacagtac tctccgggtg gtcagtgccc tccccatcca gcaccaggac      300

tggatgagtg gcaaggagtt caaatgcaag gtcaacaaca aagacctcgc tgcgcccatc      360

gagagaacca tctcaaaacc caaagggtca gtaagagctc cacaggtata tgtcttgcct      420

ccaccagaag aagagatgac taagaaacag gtcactctga cctgcatggt cacagacttc      480

atgcctgaag acatttacgt ggagtggact aacaacggga aaacagagct aaactacaag      540

aacactgaac cagtcctgga ctctgatggt tcttacttca tgtacagcaa gctgagagtg      600

gaaaagaaga actgggtgga aagaaatagc tactcctgtt cagtggtcca cgagggtctg      660

cacaatcacc acacgactaa gagcttctcc cggactccgg gctcctccaa tgaagctact      720

aacattactc caaagcataa tatgaaagca tttttggatg aattgaaagc tgagaacatc      780

aagaagttct tatataattt tacacagata ccacatttag caggaacaga acaaaacttt      840

cagcttgcaa agcaaattca atcccagtgg aaagaatttg gcctggattc tgttgagcta      900

gcacattatg atgtcctgtt gtcctaccca aataagactc atcccaacta catctcaata      960

attaatgaag atggaaatga gattttcaac acatcattat ttgaaccacc tcctccagga     1020

tatgaaaatg tttcggatat tgtaccacct ttcagtgctt tctctcctca aggaatgcca     1080

gagggcgatc tagtgtatgt taactatgca cgaactgaag acttctttaa attggaacgg     1140

gacatgaaaa tcaattgctc tgggaaaatt gtaattgcca gatatgggaa agttttcaga     1200

ggaaataagg ttaaaaatgc ccagctggca ggggccaaag gagtcattct ctactccgac     1260

cctgctgact actttgctcc tggggtgaag tcctatccag atggttggaa tcttcctgga     1320

ggtggtgtcc agcgtggaaa tatcctaaat ctgaatggtg caggagaccc tctcacacca     1380

ggttacccag caaatgaata tgcttatagg cgtggaattg cagaggctgt tggtcttcca     1440

agtattcctg ttcatccaat tggatactat gatgcacaga agctcctaga aaaaatgggt     1500

ggctcagcac caccagatag cagctggaga ggaagtctca aagtgcccta caatgttgga     1560

cctggcttta ctggaaactt ttctacacaa aaagtcaaga tgcacatcca ctctaccaat     1620

gaagtgacaa gaatttacaa tgtgataggt actctcagag gagcagtgga accagacaga     1680

tatgtcattc tgggaggtca ccgggactca tgggtgtttg gtggtattga ccctcagagt     1740

ggagcagctg ttgttcatga aattgtgagg agctttggaa cactgaaaaa ggaagggtgg     1800

agacctagaa gaacaatttt gtttgcaagc tgggatgcag aagaatttgg tcttcttggt     1860

tctactgagt gggcagagga gaactcaaga ctccttcaag agcgtggcgt ggcttatatt     1920

aatgctgact catctataga aggaaactac actctgagag ttgattgtac accgctgatg     1980

tacagcttgg tacacaacct aacaaaagag ctgaaaagcc ctgatgaagg ctttgaaggc     2040

aaatctcttt atgaaagttg gactaaaaaa agtccttccc cagagttcag tggcatgccc     2100

aggataagca aattgggatc tggaaatgat tttgaggtgt tcttccaacg acttggaatt     2160

gcttcaggca gagcacggta tactaaaaat tgggaaacaa acaaattcag cggctatcca     2220

ctgtatcaca gtgtctatga aacatatgag ttggtggaaa agttttatga tccaatgttt     2280

aaatatcacc tcactgtggc ccaggttcga ggagggatgg tgtttgagct agccaattcc     2340

atagtgctcc cttttgattg tcgagattat gctgtagttt taagaaagta tgctgacaaa     2400

atctacagta tttctatgaa acatccacag gaaatgaaga catacagtgt atcatttgat     2460

tcactttttt ctgcagtaaa gaattttaca gaaattgctt ccaagttcag tgagagactc     2520

caggactttg acaaaagcaa cccaatagta ttaagaatga tgaatgatca actcatgttt     2580

ctggaaagag catttattga tccattaggg ttaccagaca ggccttttta taggcatgtc     2640

atctatgctc caagcagcca caacaagtat gcaggggagt cattcccagg aatttatgat     2700

gctctgtttg atattgaaag caaagtggac ccttccaagg cctggggaga agtgaagaga     2760

cagatttatg ttgcagcctt cacagtgcag gcagctgcag agactttgag tgaagtagcc     2820


<210>  180
<211>  940
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mIgG Fc- human PSMA ECD Amino Acid Sequence

<400>  180

Ser Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys 
1               5                   10                  15      


Cys Pro Ala Pro Asn Ala Ala Gly Gly Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser 
    50                  55                  60                  


Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His 
65                  70                  75                  80  


Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile 
                85                  90                  95      


Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Asn Lys Asp Leu Ala Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys 
        115                 120                 125             


Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu 
    130                 135                 140                 


Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe 
145                 150                 155                 160 


Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu 
                165                 170                 175     


Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr 
            180                 185                 190         


Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg 
        195                 200                 205             


Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His 
    210                 215                 220                 


Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Ser Ser Asn Glu Ala Thr 
225                 230                 235                 240 


Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu Leu Lys 
                245                 250                 255     


Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile Pro His 
            260                 265                 270         


Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile Gln Ser 
        275                 280                 285             


Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His Tyr Asp 
    290                 295                 300                 


Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile Ser Ile 
305                 310                 315                 320 


Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe Glu Pro 
                325                 330                 335     


Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro Phe Ser 
            340                 345                 350         


Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr Val Asn 
        355                 360                 365             


Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met Lys Ile 
    370                 375                 380                 


Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val Phe Arg 
385                 390                 395                 400 


Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly Val Ile 
                405                 410                 415     


Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys Ser Tyr 
            420                 425                 430         


Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly Asn Ile 
        435                 440                 445             


Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr Pro Ala 
    450                 455                 460                 


Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly Leu Pro 
465                 470                 475                 480 


Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys Leu Leu 
                485                 490                 495     


Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg Gly Ser 
            500                 505                 510         


Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn Phe Ser 
        515                 520                 525             


Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val Thr Arg 
    530                 535                 540                 


Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro Asp Arg 
545                 550                 555                 560 


Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly Gly Ile 
                565                 570                 575     


Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg Ser Phe 
            580                 585                 590         


Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile Leu Phe 
        595                 600                 605             


Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr Glu Trp 
    610                 615                 620                 


Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala Tyr Ile 
625                 630                 635                 640 


Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val Asp Cys 
                645                 650                 655     


Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu Leu Lys 
            660                 665                 670         


Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser Trp Thr 
        675                 680                 685             


Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile Ser Lys 
    690                 695                 700                 


Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu Gly Ile 
705                 710                 715                 720 


Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn Lys Phe 
                725                 730                 735     


Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu Leu Val 
            740                 745                 750         


Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val Ala Gln 
        755                 760                 765             


Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val Leu Pro 
    770                 775                 780                 


Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala Asp Lys 
785                 790                 795                 800 


Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr Tyr Ser 
                805                 810                 815     


Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr Glu Ile 
            820                 825                 830         


Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser Asn Pro 
        835                 840                 845             


Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu Arg Ala 
    850                 855                 860                 


Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg His Val 
865                 870                 875                 880 


Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser Phe Pro 
                885                 890                 895     


Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp Pro Ser 
            900                 905                 910         


Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala Phe Thr 
        915                 920                 925             


Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
    930                 935                 940 


<210>  181
<211>  2820
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mIgG Fc-cyno PSMA ECD

<400>  181
tcgagtgagc ccagagggcc cacaatcaag ccctgtcctc catgcaaatg cccggctcca       60

aatgctgcag gtggtccatc cgtcttcatc ttccctccaa agatcaagga tgtactcatg      120

atctccctga gccccatagt cacatgtgtg gtggtggatg tgagcgagga cgacccagat      180

gtccagatca gctggtttgt gaacaacgtg gaagtacaca cagctcagac acaaacccat      240

agagaggatt acaacagtac tctccgggtg gtcagtgccc tccccatcca gcaccaggac      300

tggatgagtg gcaaggagtt caaatgcaag gtcaacaaca aagacctcgc tgcgcccatc      360

gagagaacca tctcaaaacc caaagggtca gtaagagctc cacaggtata tgtcttgcct      420

ccaccagaag aagagatgac taagaaacag gtcactctga cctgcatggt cacagacttc      480

atgcctgaag acatttacgt ggagtggact aacaacggga aaacagagct aaactacaag      540

aacactgaac cagtcctgga ctctgatggt tcttacttca tgtacagcaa gctgagagtg      600

gaaaagaaga actgggtgga aagaaatagc tactcctgtt cagtggtcca cgagggtctg      660

cacaatcacc acacgactaa gagcttctcc cggactccgg gctcctccag tgaagctact      720

aacattactc caaagcataa tatgaaagca tttttggatg aactgaaagc tgagaacatc      780

aagaagttct tacataattt tacacagata ccacatttag caggaacaga acaaaacttt      840

caacttgcaa agcaaattca atcccagtgg aaagaatttg gcctggattc tgttgagcta      900

actcattatg atgtcctgtt gtcctaccca aataagactc atcccaacta catctcaata      960

attaatgaag atggaaatga gattttcaac acatcattat ttgaaccacc tcctgcagga     1020

tatgaaaatg tttcggatat tgtaccacct ttcagtgctt tctctcctca aggaatgcca     1080

gagggcgatc tagtgtatgt taactatgca cgaactgaag acttctttaa attggaacgg     1140

gacatgaaaa tcaattgctc tgggaaaatt gtaattgcca gatatgggaa agttttcaga     1200

ggaaataagg ttaaaaatgc ccagctggca ggggccacag gagtcattct ctactcagac     1260

cctgctgact actttgctcc tggggtaaag tcttatccag atggttggaa tcttcctgga     1320

ggtggtgtcc agcgtggaaa tatcctaaat ctgaatggtg caggagaccc tctcacacca     1380

ggttacccag caaatgaata tgcttatagg cgtggaatgg cagaggctgt tggtcttcca     1440

agtattcccg ttcatccaat tgggtactat gatgcacaga agctcctaga aaaaatgggt     1500

ggctcagcat caccagatag cagctggaga ggaagtctca aagtgcccta caatgttgga     1560

cctggcttta ctggaaactt ttctacacaa aaagtcaaga tgcacatcca ctctaccagt     1620

gaagtgacaa gaatttacaa tgtgataggt actctcagag gagcagtgga accagacaga     1680

tacgtcattc tgggaggtca ccgggactca tgggtgtttg gtggtattga ccctcagagt     1740

ggagcagctg ttgttcatga aattgtgagg agctttggaa cgctgaaaaa ggaagggtgg     1800

agacctagaa gaacaatttt gtttgcaagc tgggatgcag aagaatttgg tcttcttggt     1860

tctactgaat gggcagagga gaactcaaga ctccttcaag agcgtggcgt ggcttatatt     1920

aatgctgatt cgtctataga aggaaactac actctgagag ttgattgtac accactgatg     1980

tacagcttgg tatacaacct aacaaaagag ctggaaagcc ctgatgaagg ctttgaaggc     2040

aaatctcttt atgaaagttg gactaaaaaa agtccttccc ccgagttcag tggcatgccc     2100

aggataagca aattgggatc tggaaatgat tttgaggtgt tcttccaacg acttggaatt     2160

gcctcaggca gagcacggta tactaaaaat tgggaaacaa acaaattcag cagctatcca     2220

ctgtatcaca gtgtctatga gacatatgag ttggtggaaa agttttatga tccaatgttt     2280

aaatatcacc tcactgtggc ccaggttcga ggagggatgg tgtttgaact agccaattcc     2340

gtagtgctcc cttttgattg tcgagattat gctgtagttt taagaaagta tgctgacaaa     2400

atctacaata tttctatgaa acatccacag gaaatgaaga catacagtgt atcatttgat     2460

tcactttttt ctgcagtaaa gaattttaca gaaattgctt ccaagttcag tgagagactc     2520

cgggactttg acaaaagcaa cccaatatta ttaagaatga tgaatgatca actcatgttt     2580

ctggaaagag catttattga tccattaggg ttaccagaca gaccttttta taggcatgtc     2640

atctatgctc caagcagcca caacaagtat gcaggggagt cattcccagg aatttatgat     2700

gctctgtttg atatcgaaag caaagtggac ccttcccagg cctggggaga agtgaagaga     2760

cagatttcta ttgcaacctt cacagtgcaa gcagctgcag agactttgag tgaagtggcc     2820


<210>  182
<211>  940
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mIgG Fc-cyno PSMA ECD Amino Acid Sequence

<400>  182

Ser Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys 
1               5                   10                  15      


Cys Pro Ala Pro Asn Ala Ala Gly Gly Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser 
    50                  55                  60                  


Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His 
65                  70                  75                  80  


Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile 
                85                  90                  95      


Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Asn Lys Asp Leu Ala Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys 
        115                 120                 125             


Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu 
    130                 135                 140                 


Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe 
145                 150                 155                 160 


Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu 
                165                 170                 175     


Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr 
            180                 185                 190         


Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg 
        195                 200                 205             


Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His 
    210                 215                 220                 


Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Ser Ser Ser Glu Ala Thr 
225                 230                 235                 240 


Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu Leu Lys 
                245                 250                 255     


Ala Glu Asn Ile Lys Lys Phe Leu His Asn Phe Thr Gln Ile Pro His 
            260                 265                 270         


Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile Gln Ser 
        275                 280                 285             


Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Thr His Tyr Asp 
    290                 295                 300                 


Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile Ser Ile 
305                 310                 315                 320 


Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe Glu Pro 
                325                 330                 335     


Pro Pro Ala Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro Phe Ser 
            340                 345                 350         


Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr Val Asn 
        355                 360                 365             


Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met Lys Ile 
    370                 375                 380                 


Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val Phe Arg 
385                 390                 395                 400 


Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Thr Gly Val Ile 
                405                 410                 415     


Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys Ser Tyr 
            420                 425                 430         


Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly Asn Ile 
        435                 440                 445             


Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr Pro Ala 
    450                 455                 460                 


Asn Glu Tyr Ala Tyr Arg Arg Gly Met Ala Glu Ala Val Gly Leu Pro 
465                 470                 475                 480 


Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys Leu Leu 
                485                 490                 495     


Glu Lys Met Gly Gly Ser Ala Ser Pro Asp Ser Ser Trp Arg Gly Ser 
            500                 505                 510         


Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn Phe Ser 
        515                 520                 525             


Thr Gln Lys Val Lys Met His Ile His Ser Thr Ser Glu Val Thr Arg 
    530                 535                 540                 


Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro Asp Arg 
545                 550                 555                 560 


Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly Gly Ile 
                565                 570                 575     


Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg Ser Phe 
            580                 585                 590         


Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile Leu Phe 
        595                 600                 605             


Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr Glu Trp 
    610                 615                 620                 


Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala Tyr Ile 
625                 630                 635                 640 


Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val Asp Cys 
                645                 650                 655     


Thr Pro Leu Met Tyr Ser Leu Val Tyr Asn Leu Thr Lys Glu Leu Glu 
            660                 665                 670         


Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser Trp Thr 
        675                 680                 685             


Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile Ser Lys 
    690                 695                 700                 


Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu Gly Ile 
705                 710                 715                 720 


Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn Lys Phe 
                725                 730                 735     


Ser Ser Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu Leu Val 
            740                 745                 750         


Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val Ala Gln 
        755                 760                 765             


Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Val Val Leu Pro 
    770                 775                 780                 


Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala Asp Lys 
785                 790                 795                 800 


Ile Tyr Asn Ile Ser Met Lys His Pro Gln Glu Met Lys Thr Tyr Ser 
                805                 810                 815     


Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr Glu Ile 
            820                 825                 830         


Ala Ser Lys Phe Ser Glu Arg Leu Arg Asp Phe Asp Lys Ser Asn Pro 
        835                 840                 845             


Ile Leu Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu Arg Ala 
    850                 855                 860                 


Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg His Val 
865                 870                 875                 880 


Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser Phe Pro 
                885                 890                 895     


Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp Pro Ser 
            900                 905                 910         


Gln Ala Trp Gly Glu Val Lys Arg Gln Ile Ser Ile Ala Thr Phe Thr 
        915                 920                 925             


Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
    930                 935                 940 


<210>  183
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tsc189VH Amino Acid Sequence

<400>  183

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Thr Arg Asp Thr 
    50                  55                  60                  


Ser Ser Ser Thr Ala Tyr Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  184
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01019VH Amino Acid Sequence

<400>  184

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Phe Asn Pro Tyr Asn Asp Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  185
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01020VH Amino Acid Sequence

<400>  185

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Phe Asn Pro Tyr Asn Asp Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  186
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01021VH Amino Acid Sequence

<400>  186

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  187
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01022VH Amino Acid Sequence

<400>  187

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  188
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01023VH Amino Acid Sequence

<400>  188

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  189
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01024VH Amino Acid Sequence

<400>  189

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Phe Asn Pro Tyr Asn Asp Tyr Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  190
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01025VH Amino Acid Sequence

<400>  190

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Phe Asn Pro Tyr Asn Asp Tyr Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  191
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01071VH Amino Acid Sequence

<400>  191

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  192
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGVH1-46+J6 Amino Acid Sequence

<400>  192

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  193
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tsc189VL Amino Acid Sequence

<400>  193

Asp Val Gln Ile Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  194
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01019VL Amino Acid Sequence

<400>  194

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  195
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01020VL Amino Acid Sequence

<400>  195

Asp Val Gln Ile Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  196
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01021VL Amino Acid Sequence

<400>  196

Asp Val Gln Ile Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  197
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01022VL Amino Acid Sequence

<400>  197

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  198
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01023VL Amino Acid Sequence

<400>  198

Asp Val Gln Ile Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  199
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01024VL Amino Acid Sequence

<400>  199

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  200
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01025VL Amino Acid Sequence

<400>  200

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Gly Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  201
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA01071VL Amino Acid Sequence

<400>  201

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  202
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV1-5+J1 Amino Acid Sequence

<400>  202

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  203
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS7VH Amino Acid Sequence

<400>  203

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  204
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH1-46+J4 Amino Acid Sequence

<400>  204

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  205
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIS7VL Amino Acid Sequence

<400>  205

Gln Val Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Phe Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Thr Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr 
            100                 105     


<210>  206
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VK1-39+J1 Amino Acid Sequence

<400>  206

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


