                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  NOVEL AAV CAPSIDS WITH ENDOTHELIAL TISSUE-SPECIFIC TARGETING 
       MOTIFS AND COMPOSITIONS CONTAINING SAME

<130>  UPN-20-9409.PCT

<150>  US 63/119,863
<151>  2020-12-01

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  4725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2/9 n.588.EFS nucleic acid sequence expression cassette


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  truncated promoter

<220>
<221>  promoter
<222>  (1)..(7)
<223>  p5 promoter

<220>
<221>  CDS
<222>  (37)..(1899)
<223>  AAV2-Rep

<220>
<221>  CDS
<222>  (1919)..(4162)
<223>  AAV9 Cap

<220>
<221>  misc_feature
<222>  (3683)..(3715)
<223>  EFS

<220>
<221>  misc_feature
<222>  (4253)..(4383)
<223>  p5 promoter

<220>
<221>  misc_feature
<222>  (4511)..(4725)
<223>  LacZ promoter

<400>  1
ccattttgaa gcgggaggtt tgaacgcgca gccgcc atg ccg ggg ttt tac gag         54
                                        Met Pro Gly Phe Tyr Glu           
                                        1               5                 

att gtg att aag gtc ccc agc gac ctt gac gag cat ctg ccc ggc att        102
Ile Val Ile Lys Val Pro Ser Asp Leu Asp Glu His Leu Pro Gly Ile           
            10                  15                  20                    

tct gac agc ttt gtg aac tgg gtg gcc gag aag gaa tgg gag ttg ccg        150
Ser Asp Ser Phe Val Asn Trp Val Ala Glu Lys Glu Trp Glu Leu Pro           
        25                  30                  35                        

cca gat tct gac atg gat ctg aat ctg att gag cag gca ccc ctg acc        198
Pro Asp Ser Asp Met Asp Leu Asn Leu Ile Glu Gln Ala Pro Leu Thr           
    40                  45                  50                            

gtg gcc gag aag ctg cag cgc gac ttt ctg acg gaa tgg cgc cgt gtg        246
Val Ala Glu Lys Leu Gln Arg Asp Phe Leu Thr Glu Trp Arg Arg Val           
55                  60                  65                  70            

agt aag gcc ccg gag gct ctt ttc ttt gtg caa ttt gag aag gga gag        294
Ser Lys Ala Pro Glu Ala Leu Phe Phe Val Gln Phe Glu Lys Gly Glu           
                75                  80                  85                

agc tac ttc cac atg cac gtg ctc gtg gaa acc acc ggg gtg aaa tcc        342
Ser Tyr Phe His Met His Val Leu Val Glu Thr Thr Gly Val Lys Ser           
            90                  95                  100                   

atg gtt ttg gga cgt ttc ctg agt cag att cgc gaa aaa ctg att cag        390
Met Val Leu Gly Arg Phe Leu Ser Gln Ile Arg Glu Lys Leu Ile Gln           
        105                 110                 115                       

aga att tac cgc ggg atc gag ccg act ttg cca aac tgg ttc gcg gtc        438
Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu Pro Asn Trp Phe Ala Val           
    120                 125                 130                           

aca aag acc aga aat ggc gcc gga ggc ggg aac aag gtg gtg gat gag        486
Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly Asn Lys Val Val Asp Glu           
135                 140                 145                 150           

tgc tac atc ccc aat tac ttg ctc ccc aaa acc cag cct gag ctc cag        534
Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys Thr Gln Pro Glu Leu Gln           
                155                 160                 165               

tgg gcg tgg act aat atg gaa cag tat tta agc gcc tgt ttg aat ctc        582
Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu Ser Ala Cys Leu Asn Leu           
            170                 175                 180                   

acg gag cgt aaa cgg ttg gtg gcg cag cat ctg acg cac gtg tcg cag        630
Thr Glu Arg Lys Arg Leu Val Ala Gln His Leu Thr His Val Ser Gln           
        185                 190                 195                       

acg cag gag cag aac aaa gag aat cag aat ccc aat tct gat gcg ccg        678
Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn Pro Asn Ser Asp Ala Pro           
    200                 205                 210                           

gtg atc aga tca aaa act tca gcc agg tac atg gag ctg gtc ggg tgg        726
Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr Met Glu Leu Val Gly Trp           
215                 220                 225                 230           

ctc gtg gac aag ggg att acc tcg gag aag cag tgg atc cag gag gac        774
Leu Val Asp Lys Gly Ile Thr Ser Glu Lys Gln Trp Ile Gln Glu Asp           
                235                 240                 245               

cag gcc tca tac atc tcc ttc aat gcg gcc tcc aac tcg cgg tcc caa        822
Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala Ser Asn Ser Arg Ser Gln           
            250                 255                 260                   

atc aag gct gcc ttg gac aat gcg gga aag att atg agc ctg act aaa        870
Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys Ile Met Ser Leu Thr Lys           
        265                 270                 275                       

acc gcc ccc gac tac ctg gtg ggc cag cag ccc gtg gag gac att tcc        918
Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln Pro Val Glu Asp Ile Ser           
    280                 285                 290                           

agc aat cgg att tat aaa att ttg gaa cta aac ggg tac gat ccc caa        966
Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu Asn Gly Tyr Asp Pro Gln           
295                 300                 305                 310           

tat gcg gct tcc gtc ttt ctg gga tgg gcc acg aaa aag ttc ggc aag       1014
Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala Thr Lys Lys Phe Gly Lys           
                315                 320                 325               

agg aac acc atc tgg ctg ttt ggg cct gca act acc ggg aag acc aac       1062
Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala Thr Thr Gly Lys Thr Asn           
            330                 335                 340                   

atc gcg gag gcc ata gcc cac act gtg ccc ttc tac ggg tgc gta aac       1110
Ile Ala Glu Ala Ile Ala His Thr Val Pro Phe Tyr Gly Cys Val Asn           
        345                 350                 355                       

tgg acc aat gag aac ttt ccc ttc aac gac tgt gtc gac aag atg gtg       1158
Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys Val Asp Lys Met Val           
    360                 365                 370                           

atc tgg tgg gag gag ggg aag atg acc gcc aag gtc gtg gag tcg gcc       1206
Ile Trp Trp Glu Glu Gly Lys Met Thr Ala Lys Val Val Glu Ser Ala           
375                 380                 385                 390           

aaa gcc att ctc gga gga agc aag gtg cgc gtg gac cag aaa tgc aag       1254
Lys Ala Ile Leu Gly Gly Ser Lys Val Arg Val Asp Gln Lys Cys Lys           
                395                 400                 405               

tcc tcg gcc cag ata gac ccg act ccc gtg atc gtc acc tcc aac acc       1302
Ser Ser Ala Gln Ile Asp Pro Thr Pro Val Ile Val Thr Ser Asn Thr           
            410                 415                 420                   

aac atg tgc gcc gtg att gac ggg aac tca acg acc ttc gaa cac cag       1350
Asn Met Cys Ala Val Ile Asp Gly Asn Ser Thr Thr Phe Glu His Gln           
        425                 430                 435                       

cag ccg ttg caa gac cgg atg ttc aaa ttt gaa ctc acc cgc cgt ctg       1398
Gln Pro Leu Gln Asp Arg Met Phe Lys Phe Glu Leu Thr Arg Arg Leu           
    440                 445                 450                           

gat cat gac ttt ggg aag gtc acc aag cag gaa gtc aaa gac ttt ttc       1446
Asp His Asp Phe Gly Lys Val Thr Lys Gln Glu Val Lys Asp Phe Phe           
455                 460                 465                 470           

cgg tgg gca aag gat cac gtg gtt gag gtg gag cat gaa ttc tac gtc       1494
Arg Trp Ala Lys Asp His Val Val Glu Val Glu His Glu Phe Tyr Val           
                475                 480                 485               

aaa aag ggt gga gcc aag aaa aga ccc gcc ccc agt gac gca gat ata       1542
Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala Pro Ser Asp Ala Asp Ile           
            490                 495                 500                   

agt gag ccc aaa cgg gtg cgc gag tca gtt gcg cag cca tcg acg tca       1590
Ser Glu Pro Lys Arg Val Arg Glu Ser Val Ala Gln Pro Ser Thr Ser           
        505                 510                 515                       

gac gcg gaa gct tcg atc aac tac gca gac agg tac caa aac aaa tgt       1638
Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp Arg Tyr Gln Asn Lys Cys           
    520                 525                 530                           

tct cgt cac gtg ggc atg aat ctg atg ctg ttt ccc tgc aga caa tgc       1686
Ser Arg His Val Gly Met Asn Leu Met Leu Phe Pro Cys Arg Gln Cys           
535                 540                 545                 550           

gag aga atg aat cag aat tca aat atc tgc ttc act cac gga cag aaa       1734
Glu Arg Met Asn Gln Asn Ser Asn Ile Cys Phe Thr His Gly Gln Lys           
                555                 560                 565               

gac tgt tta gag tgc ttt ccc gtg tca gaa tct caa ccc gtt tct gtc       1782
Asp Cys Leu Glu Cys Phe Pro Val Ser Glu Ser Gln Pro Val Ser Val           
            570                 575                 580                   

gtc aaa aag gcg tat cag aaa ctg tgc tac att cat cat atc atg gga       1830
Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr Ile His His Ile Met Gly           
        585                 590                 595                       

aag gtg cca gac gct tgc act gcc tgc gat ctg gtc aat gtg gat ttg       1878
Lys Val Pro Asp Ala Cys Thr Ala Cys Asp Leu Val Asn Val Asp Leu           
    600                 605                 610                           

gat gac tgc atc ttt gaa caa taaatgattt aaatcaggt atg gct gcc gat      1930
Asp Asp Cys Ile Phe Glu Gln                      Met Ala Ala Asp          
615                 620                                      625          

ggt tat ctt cca gat tgg ctc gag gac aac ctt agt gaa gga att cgc       1978
Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu Gly Ile Arg           
                630                 635                 640               

gag tgg tgg gct ttg aaa cct gga gcc cct caa ccc aag gca aat caa       2026
Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro Lys Ala Asn Gln           
            645                 650                 655                   

caa cat caa gac aac gct cga ggt ctt gtg ctt ccg ggt tac aaa tac       2074
Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly Tyr Lys Tyr           
        660                 665                 670                       

ctt gga ccc ggc aac gga ctc gac aag ggg gag ccg gtc aac gca gca       2122
Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val Asn Ala Ala           
    675                 680                 685                           

gac gcg gcg gcc ctc gag cac gac aag gcc tac gac cag cag ctc aag       2170
Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln Gln Leu Lys           
690                 695                 700                 705           

gcc gga gac aac ccg tac ctc aag tac aac cac gcc gac gcc gag ttc       2218
Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp Ala Glu Phe           
                710                 715                 720               

cag gag cgg ctc aaa gaa gat acg tct ttt ggg ggc aac ctc ggg cga       2266
Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly Asn Leu Gly Arg           
            725                 730                 735                   

gca gtc ttc cag gcc aaa aag agg ctt ctt gaa cct ctt ggt ctg gtt       2314
Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro Leu Gly Leu Val           
        740                 745                 750                       

gag gaa gcg gct aag acg gct cct gga aag aag agg cct gta gag cag       2362
Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro Val Glu Gln           
    755                 760                 765                           

tct cct cag gaa ccg gac tcc tcc gcg ggt att ggc aaa tcg ggt gca       2410
Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys Ser Gly Ala           
770                 775                 780                 785           

cag ccc gct aaa aag aga ctc aat ttc ggt cag act ggc gac aca gag       2458
Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Thr Glu           
                790                 795                 800               

tca gtc cca gac cct caa cca atc gga gaa cct ccc gca gcc ccc tca       2506
Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Ala Pro Ser           
            805                 810                 815                   

ggt gtg gga tct ctt aca atg gct tca ggt ggt ggc gca cca gtg gca       2554
Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala Pro Val Ala           
        820                 825                 830                       

gac aat aac gaa ggt gcc gat gga gtg ggt agt tcc tcg gga aat tgg       2602
Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp           
    835                 840                 845                           

cat tgc gat tcc caa tgg ctg ggg gac aga gtc atc acc acc agc acc       2650
His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr           
850                 855                 860                 865           

cga acc tgg gcc ctg ccc acc tac aac aat cac ctc tac aag caa atc       2698
Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile           
                870                 875                 880               

tcc aac agc aca tct gga gga tct tca aat gac aac gcc tac ttc ggc       2746
Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly           
            885                 890                 895                   

tac agc acc ccc tgg ggg tat ttt gac ttc aac aga ttc cac tgc cac       2794
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His           
        900                 905                 910                       

ttc tca cca cgt gac tgg cag cga ctc atc aac aac aac tgg gga ttc       2842
Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe           
    915                 920                 925                           

cgg cct aag cga ctc aac ttc aag ctc ttc aac att cag gtc aaa gag       2890
Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu           
930                 935                 940                 945           

gtt acg gac aac aat gga gtc aag acc atc gcc aat aac ctt acc agc       2938
Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser           
                950                 955                 960               

acg gtc cag gtc ttc acg gac tca gac tat cag ctc ccg tac gtg ctc       2986
Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu           
            965                 970                 975                   

ggg tcg gct cac gag ggc tgc ctc ccg ccg ttc cca gcg gac gtt ttc       3034
Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe           
        980                 985                 990                       

atg att cct cag tac ggg tat  ctg acg ctt aat gat  gga agc cag gcc     3082
Met Ile Pro Gln Tyr Gly Tyr  Leu Thr Leu Asn Asp  Gly Ser Gln Ala         
    995                 1000                 1005                         

gtg  ggt cgt tcg tcc ttt  tac tgc ctg gaa tat  ttc ccg tcg caa        3127
Val  Gly Arg Ser Ser Phe  Tyr Cys Leu Glu Tyr  Phe Pro Ser Gln            
1010                 1015                 1020                            

atg  cta aga acg ggt aac  aac ttc cag ttc agc  tac gag ttt gag        3172
Met  Leu Arg Thr Gly Asn  Asn Phe Gln Phe Ser  Tyr Glu Phe Glu            
1025                 1030                 1035                            

aac  gta cct ttc cat agc  agc tac gct cac agc  caa agc ctg gac        3217
Asn  Val Pro Phe His Ser  Ser Tyr Ala His Ser  Gln Ser Leu Asp            
1040                 1045                 1050                            

cga  cta atg aat cca ctc  atc gac caa tac ttg  tac tat ctc tca        3262
Arg  Leu Met Asn Pro Leu  Ile Asp Gln Tyr Leu  Tyr Tyr Leu Ser            
1055                 1060                 1065                            

aag  act att aac ggt tct  gga cag aat caa caa  acg cta aaa ttc        3307
Lys  Thr Ile Asn Gly Ser  Gly Gln Asn Gln Gln  Thr Leu Lys Phe            
1070                 1075                 1080                            

agt  gtg gcc gga ccc agc  aac atg gct gtc cag  gga aga aac tac        3352
Ser  Val Ala Gly Pro Ser  Asn Met Ala Val Gln  Gly Arg Asn Tyr            
1085                 1090                 1095                            

ata  cct gga ccc agc tac  cga caa caa cgt gtc  tca acc act gtg        3397
Ile  Pro Gly Pro Ser Tyr  Arg Gln Gln Arg Val  Ser Thr Thr Val            
1100                 1105                 1110                            

act  caa aac aac aac agc  gaa ttt gct tgg cct  gga gct tct tct        3442
Thr  Gln Asn Asn Asn Ser  Glu Phe Ala Trp Pro  Gly Ala Ser Ser            
1115                 1120                 1125                            

tgg  gct ctc aat gga cgt  aat agc ttg atg aat  cct gga cct gct        3487
Trp  Ala Leu Asn Gly Arg  Asn Ser Leu Met Asn  Pro Gly Pro Ala            
1130                 1135                 1140                            

atg  gcc agc cac aaa gaa  gga gag gac cgt ttc  ttt cct ttg tct        3532
Met  Ala Ser His Lys Glu  Gly Glu Asp Arg Phe  Phe Pro Leu Ser            
1145                 1150                 1155                            

gga  tct tta att ttt ggc  aaa caa gga act gga  aga gac aac gtg        3577
Gly  Ser Leu Ile Phe Gly  Lys Gln Gly Thr Gly  Arg Asp Asn Val            
1160                 1165                 1170                            

gat  gcg gac aaa gtc atg  ata acc aac gaa gaa  gaa att aaa act        3622
Asp  Ala Asp Lys Val Met  Ile Thr Asn Glu Glu  Glu Ile Lys Thr            
1175                 1180                 1185                            

act  aac ccg gta gca acg  gag tcc tat gga caa  gtg gcc aca aac        3667
Thr  Asn Pro Val Ala Thr  Glu Ser Tyr Gly Gln  Val Ala Thr Asn            
1190                 1195                 1200                            

cac  cag agt gcc caa gag  ttc agc agc aac acc  gtg aag ctg acc        3712
His  Gln Ser Ala Gln Glu  Phe Ser Ser Asn Thr  Val Lys Leu Thr            
1205                 1210                 1215                            

agc  gca cag gcg cag acc  ggc tgg gtt caa aac  caa gga ata ctt        3757
Ser  Ala Gln Ala Gln Thr  Gly Trp Val Gln Asn  Gln Gly Ile Leu            
1220                 1225                 1230                            

ccg  ggt atg gtt tgg cag  gac aga gat gtg tac  ctg caa gga ccc        3802
Pro  Gly Met Val Trp Gln  Asp Arg Asp Val Tyr  Leu Gln Gly Pro            
1235                 1240                 1245                            

att  tgg gcc aaa att cct  cac acg gac ggc aac  ttt cac cct tct        3847
Ile  Trp Ala Lys Ile Pro  His Thr Asp Gly Asn  Phe His Pro Ser            
1250                 1255                 1260                            

ccg  ctg atg gga ggg ttt  gga atg aag cac ccg  cct cct cag atc        3892
Pro  Leu Met Gly Gly Phe  Gly Met Lys His Pro  Pro Pro Gln Ile            
1265                 1270                 1275                            

ctc  atc aaa aac aca cct  gta cct gcg gat cct  cca acg gcc ttc        3937
Leu  Ile Lys Asn Thr Pro  Val Pro Ala Asp Pro  Pro Thr Ala Phe            
1280                 1285                 1290                            

aac  aag gac aag ctg aac  tct ttc atc acc cag  tat tct act ggc        3982
Asn  Lys Asp Lys Leu Asn  Ser Phe Ile Thr Gln  Tyr Ser Thr Gly            
1295                 1300                 1305                            

caa  gtc agc gtg gag atc  gag tgg gag ctg cag  aag gaa aac agc        4027
Gln  Val Ser Val Glu Ile  Glu Trp Glu Leu Gln  Lys Glu Asn Ser            
1310                 1315                 1320                            

aag  cgc tgg aac ccg gag  atc cag tac act tcc  aac tat tac aag        4072
Lys  Arg Trp Asn Pro Glu  Ile Gln Tyr Thr Ser  Asn Tyr Tyr Lys            
1325                 1330                 1335                            

tct  aat aat gtt gaa ttt  gct gtt aat act gaa  ggt gta tat agt        4117
Ser  Asn Asn Val Glu Phe  Ala Val Asn Thr Glu  Gly Val Tyr Ser            
1340                 1345                 1350                            

gaa  ccc cgc ccc att ggc  acc aga tac ctg act  cgt aat ctg taa        4162
Glu  Pro Arg Pro Ile Gly  Thr Arg Tyr Leu Thr  Arg Asn Leu                
1355                 1360                 1365                            

ttgcttgtta atcaataaac cgtttaattc gtttcagttg aactttggtc tctgcgaagg     4222

gcgaattcgt ttaaacctgc aggactagag gtcctgtatt agaggtcacg tgagtgtttt     4282

gcgacatttt gcgacaccat gtggtcacgc tgggtattta agcccgagtg agcacgcagg     4342

gtctccattt tgaagcggga ggtttgaacg cgcagccgcc aagccgaatt ctgcagatat     4402

ccatcacact ggcggccgct cgactagagc ggccgccacc gcggtggagc tccagctttt     4462

gttcccttta gtgagggtta attgcgcgct tggcgtaatc atggtcatag ctgtttcctg     4522

tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta     4582

aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg     4642

ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga     4702

gaggcggttt gcgtattggg cgc                                             4725


<210>  2
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210>  3
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Glu Phe Ser Ser 
            580                 585                 590         


Asn Thr Val Lys Leu Thr Ser Ala Gln Ala Gln Thr Gly Trp Val Gln 
        595                 600                 605             


Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr 
    610                 615                 620                 


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
625                 630                 635                 640 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro 
                645                 650                 655     


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala 
            660                 665                 670         


Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
        675                 680                 685             


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
    690                 695                 700                 


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn 
705                 710                 715                 720 


Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg 
                725                 730                 735     


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745         


<210>  4
<211>  4728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2/9 n.588.IEI nucleic acid sequence expression cassette


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  truncated promoter

<220>
<221>  promoter
<222>  (1)..(7)
<223>  p5 promoter

<220>
<221>  CDS
<222>  (37)..(1899)
<223>  AAV2-Rep

<220>
<221>  CDS
<222>  (1919)..(4165)
<223>  AAV9 Cap

<220>
<221>  misc_feature
<222>  (3683)..(3718)
<223>  IEI

<220>
<221>  misc_feature
<222>  (4256)..(4386)
<223>  p5 promoter

<220>
<221>  misc_feature
<222>  (4514)..(4728)
<223>  LacZ promoter

<400>  4
ccattttgaa gcgggaggtt tgaacgcgca gccgcc atg ccg ggg ttt tac gag         54
                                        Met Pro Gly Phe Tyr Glu           
                                        1               5                 

att gtg att aag gtc ccc agc gac ctt gac gag cat ctg ccc ggc att        102
Ile Val Ile Lys Val Pro Ser Asp Leu Asp Glu His Leu Pro Gly Ile           
            10                  15                  20                    

tct gac agc ttt gtg aac tgg gtg gcc gag aag gaa tgg gag ttg ccg        150
Ser Asp Ser Phe Val Asn Trp Val Ala Glu Lys Glu Trp Glu Leu Pro           
        25                  30                  35                        

cca gat tct gac atg gat ctg aat ctg att gag cag gca ccc ctg acc        198
Pro Asp Ser Asp Met Asp Leu Asn Leu Ile Glu Gln Ala Pro Leu Thr           
    40                  45                  50                            

gtg gcc gag aag ctg cag cgc gac ttt ctg acg gaa tgg cgc cgt gtg        246
Val Ala Glu Lys Leu Gln Arg Asp Phe Leu Thr Glu Trp Arg Arg Val           
55                  60                  65                  70            

agt aag gcc ccg gag gct ctt ttc ttt gtg caa ttt gag aag gga gag        294
Ser Lys Ala Pro Glu Ala Leu Phe Phe Val Gln Phe Glu Lys Gly Glu           
                75                  80                  85                

agc tac ttc cac atg cac gtg ctc gtg gaa acc acc ggg gtg aaa tcc        342
Ser Tyr Phe His Met His Val Leu Val Glu Thr Thr Gly Val Lys Ser           
            90                  95                  100                   

atg gtt ttg gga cgt ttc ctg agt cag att cgc gaa aaa ctg att cag        390
Met Val Leu Gly Arg Phe Leu Ser Gln Ile Arg Glu Lys Leu Ile Gln           
        105                 110                 115                       

aga att tac cgc ggg atc gag ccg act ttg cca aac tgg ttc gcg gtc        438
Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu Pro Asn Trp Phe Ala Val           
    120                 125                 130                           

aca aag acc aga aat ggc gcc gga ggc ggg aac aag gtg gtg gat gag        486
Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly Asn Lys Val Val Asp Glu           
135                 140                 145                 150           

tgc tac atc ccc aat tac ttg ctc ccc aaa acc cag cct gag ctc cag        534
Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys Thr Gln Pro Glu Leu Gln           
                155                 160                 165               

tgg gcg tgg act aat atg gaa cag tat tta agc gcc tgt ttg aat ctc        582
Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu Ser Ala Cys Leu Asn Leu           
            170                 175                 180                   

acg gag cgt aaa cgg ttg gtg gcg cag cat ctg acg cac gtg tcg cag        630
Thr Glu Arg Lys Arg Leu Val Ala Gln His Leu Thr His Val Ser Gln           
        185                 190                 195                       

acg cag gag cag aac aaa gag aat cag aat ccc aat tct gat gcg ccg        678
Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn Pro Asn Ser Asp Ala Pro           
    200                 205                 210                           

gtg atc aga tca aaa act tca gcc agg tac atg gag ctg gtc ggg tgg        726
Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr Met Glu Leu Val Gly Trp           
215                 220                 225                 230           

ctc gtg gac aag ggg att acc tcg gag aag cag tgg atc cag gag gac        774
Leu Val Asp Lys Gly Ile Thr Ser Glu Lys Gln Trp Ile Gln Glu Asp           
                235                 240                 245               

cag gcc tca tac atc tcc ttc aat gcg gcc tcc aac tcg cgg tcc caa        822
Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala Ser Asn Ser Arg Ser Gln           
            250                 255                 260                   

atc aag gct gcc ttg gac aat gcg gga aag att atg agc ctg act aaa        870
Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys Ile Met Ser Leu Thr Lys           
        265                 270                 275                       

acc gcc ccc gac tac ctg gtg ggc cag cag ccc gtg gag gac att tcc        918
Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln Pro Val Glu Asp Ile Ser           
    280                 285                 290                           

agc aat cgg att tat aaa att ttg gaa cta aac ggg tac gat ccc caa        966
Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu Asn Gly Tyr Asp Pro Gln           
295                 300                 305                 310           

tat gcg gct tcc gtc ttt ctg gga tgg gcc acg aaa aag ttc ggc aag       1014
Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala Thr Lys Lys Phe Gly Lys           
                315                 320                 325               

agg aac acc atc tgg ctg ttt ggg cct gca act acc ggg aag acc aac       1062
Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala Thr Thr Gly Lys Thr Asn           
            330                 335                 340                   

atc gcg gag gcc ata gcc cac act gtg ccc ttc tac ggg tgc gta aac       1110
Ile Ala Glu Ala Ile Ala His Thr Val Pro Phe Tyr Gly Cys Val Asn           
        345                 350                 355                       

tgg acc aat gag aac ttt ccc ttc aac gac tgt gtc gac aag atg gtg       1158
Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys Val Asp Lys Met Val           
    360                 365                 370                           

atc tgg tgg gag gag ggg aag atg acc gcc aag gtc gtg gag tcg gcc       1206
Ile Trp Trp Glu Glu Gly Lys Met Thr Ala Lys Val Val Glu Ser Ala           
375                 380                 385                 390           

aaa gcc att ctc gga gga agc aag gtg cgc gtg gac cag aaa tgc aag       1254
Lys Ala Ile Leu Gly Gly Ser Lys Val Arg Val Asp Gln Lys Cys Lys           
                395                 400                 405               

tcc tcg gcc cag ata gac ccg act ccc gtg atc gtc acc tcc aac acc       1302
Ser Ser Ala Gln Ile Asp Pro Thr Pro Val Ile Val Thr Ser Asn Thr           
            410                 415                 420                   

aac atg tgc gcc gtg att gac ggg aac tca acg acc ttc gaa cac cag       1350
Asn Met Cys Ala Val Ile Asp Gly Asn Ser Thr Thr Phe Glu His Gln           
        425                 430                 435                       

cag ccg ttg caa gac cgg atg ttc aaa ttt gaa ctc acc cgc cgt ctg       1398
Gln Pro Leu Gln Asp Arg Met Phe Lys Phe Glu Leu Thr Arg Arg Leu           
    440                 445                 450                           

gat cat gac ttt ggg aag gtc acc aag cag gaa gtc aaa gac ttt ttc       1446
Asp His Asp Phe Gly Lys Val Thr Lys Gln Glu Val Lys Asp Phe Phe           
455                 460                 465                 470           

cgg tgg gca aag gat cac gtg gtt gag gtg gag cat gaa ttc tac gtc       1494
Arg Trp Ala Lys Asp His Val Val Glu Val Glu His Glu Phe Tyr Val           
                475                 480                 485               

aaa aag ggt gga gcc aag aaa aga ccc gcc ccc agt gac gca gat ata       1542
Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala Pro Ser Asp Ala Asp Ile           
            490                 495                 500                   

agt gag ccc aaa cgg gtg cgc gag tca gtt gcg cag cca tcg acg tca       1590
Ser Glu Pro Lys Arg Val Arg Glu Ser Val Ala Gln Pro Ser Thr Ser           
        505                 510                 515                       

gac gcg gaa gct tcg atc aac tac gca gac agg tac caa aac aaa tgt       1638
Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp Arg Tyr Gln Asn Lys Cys           
    520                 525                 530                           

tct cgt cac gtg ggc atg aat ctg atg ctg ttt ccc tgc aga caa tgc       1686
Ser Arg His Val Gly Met Asn Leu Met Leu Phe Pro Cys Arg Gln Cys           
535                 540                 545                 550           

gag aga atg aat cag aat tca aat atc tgc ttc act cac gga cag aaa       1734
Glu Arg Met Asn Gln Asn Ser Asn Ile Cys Phe Thr His Gly Gln Lys           
                555                 560                 565               

gac tgt tta gag tgc ttt ccc gtg tca gaa tct caa ccc gtt tct gtc       1782
Asp Cys Leu Glu Cys Phe Pro Val Ser Glu Ser Gln Pro Val Ser Val           
            570                 575                 580                   

gtc aaa aag gcg tat cag aaa ctg tgc tac att cat cat atc atg gga       1830
Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr Ile His His Ile Met Gly           
        585                 590                 595                       

aag gtg cca gac gct tgc act gcc tgc gat ctg gtc aat gtg gat ttg       1878
Lys Val Pro Asp Ala Cys Thr Ala Cys Asp Leu Val Asn Val Asp Leu           
    600                 605                 610                           

gat gac tgc atc ttt gaa caa taaatgattt aaatcaggt atg gct gcc gat      1930
Asp Asp Cys Ile Phe Glu Gln                      Met Ala Ala Asp          
615                 620                                      625          

ggt tat ctt cca gat tgg ctc gag gac aac ctt agt gaa gga att cgc       1978
Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu Gly Ile Arg           
                630                 635                 640               

gag tgg tgg gct ttg aaa cct gga gcc cct caa ccc aag gca aat caa       2026
Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro Lys Ala Asn Gln           
            645                 650                 655                   

caa cat caa gac aac gct cga ggt ctt gtg ctt ccg ggt tac aaa tac       2074
Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly Tyr Lys Tyr           
        660                 665                 670                       

ctt gga ccc ggc aac gga ctc gac aag ggg gag ccg gtc aac gca gca       2122
Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val Asn Ala Ala           
    675                 680                 685                           

gac gcg gcg gcc ctc gag cac gac aag gcc tac gac cag cag ctc aag       2170
Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln Gln Leu Lys           
690                 695                 700                 705           

gcc gga gac aac ccg tac ctc aag tac aac cac gcc gac gcc gag ttc       2218
Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp Ala Glu Phe           
                710                 715                 720               

cag gag cgg ctc aaa gaa gat acg tct ttt ggg ggc aac ctc ggg cga       2266
Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly Asn Leu Gly Arg           
            725                 730                 735                   

gca gtc ttc cag gcc aaa aag agg ctt ctt gaa cct ctt ggt ctg gtt       2314
Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro Leu Gly Leu Val           
        740                 745                 750                       

gag gaa gcg gct aag acg gct cct gga aag aag agg cct gta gag cag       2362
Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro Val Glu Gln           
    755                 760                 765                           

tct cct cag gaa ccg gac tcc tcc gcg ggt att ggc aaa tcg ggt gca       2410
Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys Ser Gly Ala           
770                 775                 780                 785           

cag ccc gct aaa aag aga ctc aat ttc ggt cag act ggc gac aca gag       2458
Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Thr Glu           
                790                 795                 800               

tca gtc cca gac cct caa cca atc gga gaa cct ccc gca gcc ccc tca       2506
Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Ala Pro Ser           
            805                 810                 815                   

ggt gtg gga tct ctt aca atg gct tca ggt ggt ggc gca cca gtg gca       2554
Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala Pro Val Ala           
        820                 825                 830                       

gac aat aac gaa ggt gcc gat gga gtg ggt agt tcc tcg gga aat tgg       2602
Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp           
    835                 840                 845                           

cat tgc gat tcc caa tgg ctg ggg gac aga gtc atc acc acc agc acc       2650
His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr           
850                 855                 860                 865           

cga acc tgg gcc ctg ccc acc tac aac aat cac ctc tac aag caa atc       2698
Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile           
                870                 875                 880               

tcc aac agc aca tct gga gga tct tca aat gac aac gcc tac ttc ggc       2746
Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly           
            885                 890                 895                   

tac agc acc ccc tgg ggg tat ttt gac ttc aac aga ttc cac tgc cac       2794
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His           
        900                 905                 910                       

ttc tca cca cgt gac tgg cag cga ctc atc aac aac aac tgg gga ttc       2842
Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe           
    915                 920                 925                           

cgg cct aag cga ctc aac ttc aag ctc ttc aac att cag gtc aaa gag       2890
Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu           
930                 935                 940                 945           

gtt acg gac aac aat gga gtc aag acc atc gcc aat aac ctt acc agc       2938
Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser           
                950                 955                 960               

acg gtc cag gtc ttc acg gac tca gac tat cag ctc ccg tac gtg ctc       2986
Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu           
            965                 970                 975                   

ggg tcg gct cac gag ggc tgc ctc ccg ccg ttc cca gcg gac gtt ttc       3034
Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe           
        980                 985                 990                       

atg att cct cag tac ggg tat  ctg acg ctt aat gat  gga agc cag gcc     3082
Met Ile Pro Gln Tyr Gly Tyr  Leu Thr Leu Asn Asp  Gly Ser Gln Ala         
    995                 1000                 1005                         

gtg  ggt cgt tcg tcc ttt  tac tgc ctg gaa tat  ttc ccg tcg caa        3127
Val  Gly Arg Ser Ser Phe  Tyr Cys Leu Glu Tyr  Phe Pro Ser Gln            
1010                 1015                 1020                            

atg  cta aga acg ggt aac  aac ttc cag ttc agc  tac gag ttt gag        3172
Met  Leu Arg Thr Gly Asn  Asn Phe Gln Phe Ser  Tyr Glu Phe Glu            
1025                 1030                 1035                            

aac  gta cct ttc cat agc  agc tac gct cac agc  caa agc ctg gac        3217
Asn  Val Pro Phe His Ser  Ser Tyr Ala His Ser  Gln Ser Leu Asp            
1040                 1045                 1050                            

cga  cta atg aat cca ctc  atc gac caa tac ttg  tac tat ctc tca        3262
Arg  Leu Met Asn Pro Leu  Ile Asp Gln Tyr Leu  Tyr Tyr Leu Ser            
1055                 1060                 1065                            

aag  act att aac ggt tct  gga cag aat caa caa  acg cta aaa ttc        3307
Lys  Thr Ile Asn Gly Ser  Gly Gln Asn Gln Gln  Thr Leu Lys Phe            
1070                 1075                 1080                            

agt  gtg gcc gga ccc agc  aac atg gct gtc cag  gga aga aac tac        3352
Ser  Val Ala Gly Pro Ser  Asn Met Ala Val Gln  Gly Arg Asn Tyr            
1085                 1090                 1095                            

ata  cct gga ccc agc tac  cga caa caa cgt gtc  tca acc act gtg        3397
Ile  Pro Gly Pro Ser Tyr  Arg Gln Gln Arg Val  Ser Thr Thr Val            
1100                 1105                 1110                            

act  caa aac aac aac agc  gaa ttt gct tgg cct  gga gct tct tct        3442
Thr  Gln Asn Asn Asn Ser  Glu Phe Ala Trp Pro  Gly Ala Ser Ser            
1115                 1120                 1125                            

tgg  gct ctc aat gga cgt  aat agc ttg atg aat  cct gga cct gct        3487
Trp  Ala Leu Asn Gly Arg  Asn Ser Leu Met Asn  Pro Gly Pro Ala            
1130                 1135                 1140                            

atg  gcc agc cac aaa gaa  gga gag gac cgt ttc  ttt cct ttg tct        3532
Met  Ala Ser His Lys Glu  Gly Glu Asp Arg Phe  Phe Pro Leu Ser            
1145                 1150                 1155                            

gga  tct tta att ttt ggc  aaa caa gga act gga  aga gac aac gtg        3577
Gly  Ser Leu Ile Phe Gly  Lys Gln Gly Thr Gly  Arg Asp Asn Val            
1160                 1165                 1170                            

gat  gcg gac aaa gtc atg  ata acc aac gaa gaa  gaa att aaa act        3622
Asp  Ala Asp Lys Val Met  Ile Thr Asn Glu Glu  Glu Ile Lys Thr            
1175                 1180                 1185                            

act  aac ccg gta gca acg  gag tcc tat gga caa  gtg gcc aca aac        3667
Thr  Asn Pro Val Ala Thr  Glu Ser Tyr Gly Gln  Val Ala Thr Asn            
1190                 1195                 1200                            

cac  cag agt gcc caa atc  gag atc aac gct acc  aga gct gga acc        3712
His  Gln Ser Ala Gln Ile  Glu Ile Asn Ala Thr  Arg Ala Gly Thr            
1205                 1210                 1215                            

aac  ctg gca cag gcg cag  acc ggc tgg gtt caa  aac caa gga ata        3757
Asn  Leu Ala Gln Ala Gln  Thr Gly Trp Val Gln  Asn Gln Gly Ile            
1220                 1225                 1230                            

ctt  ccg ggt atg gtt tgg  cag gac aga gat gtg  tac ctg caa gga        3802
Leu  Pro Gly Met Val Trp  Gln Asp Arg Asp Val  Tyr Leu Gln Gly            
1235                 1240                 1245                            

ccc  att tgg gcc aaa att  cct cac acg gac ggc  aac ttt cac cct        3847
Pro  Ile Trp Ala Lys Ile  Pro His Thr Asp Gly  Asn Phe His Pro            
1250                 1255                 1260                            

tct  ccg ctg atg gga ggg  ttt gga atg aag cac  ccg cct cct cag        3892
Ser  Pro Leu Met Gly Gly  Phe Gly Met Lys His  Pro Pro Pro Gln            
1265                 1270                 1275                            

atc  ctc atc aaa aac aca  cct gta cct gcg gat  cct cca acg gcc        3937
Ile  Leu Ile Lys Asn Thr  Pro Val Pro Ala Asp  Pro Pro Thr Ala            
1280                 1285                 1290                            

ttc  aac aag gac aag ctg  aac tct ttc atc acc  cag tat tct act        3982
Phe  Asn Lys Asp Lys Leu  Asn Ser Phe Ile Thr  Gln Tyr Ser Thr            
1295                 1300                 1305                            

ggc  caa gtc agc gtg gag  atc gag tgg gag ctg  cag aag gaa aac        4027
Gly  Gln Val Ser Val Glu  Ile Glu Trp Glu Leu  Gln Lys Glu Asn            
1310                 1315                 1320                            

agc  aag cgc tgg aac ccg  gag atc cag tac act  tcc aac tat tac        4072
Ser  Lys Arg Trp Asn Pro  Glu Ile Gln Tyr Thr  Ser Asn Tyr Tyr            
1325                 1330                 1335                            

aag  tct aat aat gtt gaa  ttt gct gtt aat act  gaa ggt gta tat        4117
Lys  Ser Asn Asn Val Glu  Phe Ala Val Asn Thr  Glu Gly Val Tyr            
1340                 1345                 1350                            

agt  gaa ccc cgc ccc att  ggc acc aga tac ctg  act cgt aat ctg        4162
Ser  Glu Pro Arg Pro Ile  Gly Thr Arg Tyr Leu  Thr Arg Asn Leu            
1355                 1360                 1365                            

taa ttgcttgtta atcaataaac cgtttaattc gtttcagttg aactttggtc            4215

tctgcgaagg gcgaattcgt ttaaacctgc aggactagag gtcctgtatt agaggtcacg     4275

tgagtgtttt gcgacatttt gcgacaccat gtggtcacgc tgggtattta agcccgagtg     4335

agcacgcagg gtctccattt tgaagcggga ggtttgaacg cgcagccgcc aagccgaatt     4395

ctgcagatat ccatcacact ggcggccgct cgactagagc ggccgccacc gcggtggagc     4455

tccagctttt gttcccttta gtgagggtta attgcgcgct tggcgtaatc atggtcatag     4515

ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc     4575

ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc     4635

tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa     4695

cgcgcgggga gaggcggttt gcgtattggg cgc                                  4728


<210>  5
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210>  6
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ile Glu Ile Asn 
            580                 585                 590         


Ala Thr Arg Ala Gly Thr Asn Leu Ala Gln Ala Gln Thr Gly Trp Val 
        595                 600                 605             


Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val 
    610                 615                 620                 


Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn 
625                 630                 635                 640 


Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His Pro Pro 
                645                 650                 655     


Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr 
            660                 665                 670         


Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr 
        675                 680                 685             


Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser 
    690                 695                 700                 


Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser 
705                 710                 715                 720 


Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro 
                725                 730                 735     


Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745             


<210>  7
<211>  4740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2/9 n.588.IEI-L nucleic acid sequence epxression cassette


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  trunccated promoter

<220>
<221>  promoter
<222>  (1)..(7)
<223>  p5 Promoter

<220>
<221>  CDS
<222>  (37)..(1899)
<223>  AAV2 Rep

<220>
<221>  CDS
<222>  (1919)..(4177)
<223>  AAV9 Cap

<220>
<221>  misc_feature
<222>  (3683)..(3739)
<223>  IEI-L

<220>
<221>  misc_feature
<222>  (4268)..(4398)
<223>  p5 promoter

<220>
<221>  misc_feature
<222>  (4526)..(4740)
<223>  LacZ promoter

<400>  7
ccattttgaa gcgggaggtt tgaacgcgca gccgcc atg ccg ggg ttt tac gag         54
                                        Met Pro Gly Phe Tyr Glu           
                                        1               5                 

att gtg att aag gtc ccc agc gac ctt gac gag cat ctg ccc ggc att        102
Ile Val Ile Lys Val Pro Ser Asp Leu Asp Glu His Leu Pro Gly Ile           
            10                  15                  20                    

tct gac agc ttt gtg aac tgg gtg gcc gag aag gaa tgg gag ttg ccg        150
Ser Asp Ser Phe Val Asn Trp Val Ala Glu Lys Glu Trp Glu Leu Pro           
        25                  30                  35                        

cca gat tct gac atg gat ctg aat ctg att gag cag gca ccc ctg acc        198
Pro Asp Ser Asp Met Asp Leu Asn Leu Ile Glu Gln Ala Pro Leu Thr           
    40                  45                  50                            

gtg gcc gag aag ctg cag cgc gac ttt ctg acg gaa tgg cgc cgt gtg        246
Val Ala Glu Lys Leu Gln Arg Asp Phe Leu Thr Glu Trp Arg Arg Val           
55                  60                  65                  70            

agt aag gcc ccg gag gct ctt ttc ttt gtg caa ttt gag aag gga gag        294
Ser Lys Ala Pro Glu Ala Leu Phe Phe Val Gln Phe Glu Lys Gly Glu           
                75                  80                  85                

agc tac ttc cac atg cac gtg ctc gtg gaa acc acc ggg gtg aaa tcc        342
Ser Tyr Phe His Met His Val Leu Val Glu Thr Thr Gly Val Lys Ser           
            90                  95                  100                   

atg gtt ttg gga cgt ttc ctg agt cag att cgc gaa aaa ctg att cag        390
Met Val Leu Gly Arg Phe Leu Ser Gln Ile Arg Glu Lys Leu Ile Gln           
        105                 110                 115                       

aga att tac cgc ggg atc gag ccg act ttg cca aac tgg ttc gcg gtc        438
Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu Pro Asn Trp Phe Ala Val           
    120                 125                 130                           

aca aag acc aga aat ggc gcc gga ggc ggg aac aag gtg gtg gat gag        486
Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly Asn Lys Val Val Asp Glu           
135                 140                 145                 150           

tgc tac atc ccc aat tac ttg ctc ccc aaa acc cag cct gag ctc cag        534
Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys Thr Gln Pro Glu Leu Gln           
                155                 160                 165               

tgg gcg tgg act aat atg gaa cag tat tta agc gcc tgt ttg aat ctc        582
Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu Ser Ala Cys Leu Asn Leu           
            170                 175                 180                   

acg gag cgt aaa cgg ttg gtg gcg cag cat ctg acg cac gtg tcg cag        630
Thr Glu Arg Lys Arg Leu Val Ala Gln His Leu Thr His Val Ser Gln           
        185                 190                 195                       

acg cag gag cag aac aaa gag aat cag aat ccc aat tct gat gcg ccg        678
Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn Pro Asn Ser Asp Ala Pro           
    200                 205                 210                           

gtg atc aga tca aaa act tca gcc agg tac atg gag ctg gtc ggg tgg        726
Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr Met Glu Leu Val Gly Trp           
215                 220                 225                 230           

ctc gtg gac aag ggg att acc tcg gag aag cag tgg atc cag gag gac        774
Leu Val Asp Lys Gly Ile Thr Ser Glu Lys Gln Trp Ile Gln Glu Asp           
                235                 240                 245               

cag gcc tca tac atc tcc ttc aat gcg gcc tcc aac tcg cgg tcc caa        822
Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala Ser Asn Ser Arg Ser Gln           
            250                 255                 260                   

atc aag gct gcc ttg gac aat gcg gga aag att atg agc ctg act aaa        870
Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys Ile Met Ser Leu Thr Lys           
        265                 270                 275                       

acc gcc ccc gac tac ctg gtg ggc cag cag ccc gtg gag gac att tcc        918
Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln Pro Val Glu Asp Ile Ser           
    280                 285                 290                           

agc aat cgg att tat aaa att ttg gaa cta aac ggg tac gat ccc caa        966
Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu Asn Gly Tyr Asp Pro Gln           
295                 300                 305                 310           

tat gcg gct tcc gtc ttt ctg gga tgg gcc acg aaa aag ttc ggc aag       1014
Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala Thr Lys Lys Phe Gly Lys           
                315                 320                 325               

agg aac acc atc tgg ctg ttt ggg cct gca act acc ggg aag acc aac       1062
Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala Thr Thr Gly Lys Thr Asn           
            330                 335                 340                   

atc gcg gag gcc ata gcc cac act gtg ccc ttc tac ggg tgc gta aac       1110
Ile Ala Glu Ala Ile Ala His Thr Val Pro Phe Tyr Gly Cys Val Asn           
        345                 350                 355                       

tgg acc aat gag aac ttt ccc ttc aac gac tgt gtc gac aag atg gtg       1158
Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys Val Asp Lys Met Val           
    360                 365                 370                           

atc tgg tgg gag gag ggg aag atg acc gcc aag gtc gtg gag tcg gcc       1206
Ile Trp Trp Glu Glu Gly Lys Met Thr Ala Lys Val Val Glu Ser Ala           
375                 380                 385                 390           

aaa gcc att ctc gga gga agc aag gtg cgc gtg gac cag aaa tgc aag       1254
Lys Ala Ile Leu Gly Gly Ser Lys Val Arg Val Asp Gln Lys Cys Lys           
                395                 400                 405               

tcc tcg gcc cag ata gac ccg act ccc gtg atc gtc acc tcc aac acc       1302
Ser Ser Ala Gln Ile Asp Pro Thr Pro Val Ile Val Thr Ser Asn Thr           
            410                 415                 420                   

aac atg tgc gcc gtg att gac ggg aac tca acg acc ttc gaa cac cag       1350
Asn Met Cys Ala Val Ile Asp Gly Asn Ser Thr Thr Phe Glu His Gln           
        425                 430                 435                       

cag ccg ttg caa gac cgg atg ttc aaa ttt gaa ctc acc cgc cgt ctg       1398
Gln Pro Leu Gln Asp Arg Met Phe Lys Phe Glu Leu Thr Arg Arg Leu           
    440                 445                 450                           

gat cat gac ttt ggg aag gtc acc aag cag gaa gtc aaa gac ttt ttc       1446
Asp His Asp Phe Gly Lys Val Thr Lys Gln Glu Val Lys Asp Phe Phe           
455                 460                 465                 470           

cgg tgg gca aag gat cac gtg gtt gag gtg gag cat gaa ttc tac gtc       1494
Arg Trp Ala Lys Asp His Val Val Glu Val Glu His Glu Phe Tyr Val           
                475                 480                 485               

aaa aag ggt gga gcc aag aaa aga ccc gcc ccc agt gac gca gat ata       1542
Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala Pro Ser Asp Ala Asp Ile           
            490                 495                 500                   

agt gag ccc aaa cgg gtg cgc gag tca gtt gcg cag cca tcg acg tca       1590
Ser Glu Pro Lys Arg Val Arg Glu Ser Val Ala Gln Pro Ser Thr Ser           
        505                 510                 515                       

gac gcg gaa gct tcg atc aac tac gca gac agg tac caa aac aaa tgt       1638
Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp Arg Tyr Gln Asn Lys Cys           
    520                 525                 530                           

tct cgt cac gtg ggc atg aat ctg atg ctg ttt ccc tgc aga caa tgc       1686
Ser Arg His Val Gly Met Asn Leu Met Leu Phe Pro Cys Arg Gln Cys           
535                 540                 545                 550           

gag aga atg aat cag aat tca aat atc tgc ttc act cac gga cag aaa       1734
Glu Arg Met Asn Gln Asn Ser Asn Ile Cys Phe Thr His Gly Gln Lys           
                555                 560                 565               

gac tgt tta gag tgc ttt ccc gtg tca gaa tct caa ccc gtt tct gtc       1782
Asp Cys Leu Glu Cys Phe Pro Val Ser Glu Ser Gln Pro Val Ser Val           
            570                 575                 580                   

gtc aaa aag gcg tat cag aaa ctg tgc tac att cat cat atc atg gga       1830
Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr Ile His His Ile Met Gly           
        585                 590                 595                       

aag gtg cca gac gct tgc act gcc tgc gat ctg gtc aat gtg gat ttg       1878
Lys Val Pro Asp Ala Cys Thr Ala Cys Asp Leu Val Asn Val Asp Leu           
    600                 605                 610                           

gat gac tgc atc ttt gaa caa taaatgattt aaatcaggt atg gct gcc gat      1930
Asp Asp Cys Ile Phe Glu Gln                      Met Ala Ala Asp          
615                 620                                      625          

ggt tat ctt cca gat tgg ctc gag gac aac ctt agt gaa gga att cgc       1978
Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu Gly Ile Arg           
                630                 635                 640               

gag tgg tgg gct ttg aaa cct gga gcc cct caa ccc aag gca aat caa       2026
Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro Lys Ala Asn Gln           
            645                 650                 655                   

caa cat caa gac aac gct cga ggt ctt gtg ctt ccg ggt tac aaa tac       2074
Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly Tyr Lys Tyr           
        660                 665                 670                       

ctt gga ccc ggc aac gga ctc gac aag ggg gag ccg gtc aac gca gca       2122
Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val Asn Ala Ala           
    675                 680                 685                           

gac gcg gcg gcc ctc gag cac gac aag gcc tac gac cag cag ctc aag       2170
Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln Gln Leu Lys           
690                 695                 700                 705           

gcc gga gac aac ccg tac ctc aag tac aac cac gcc gac gcc gag ttc       2218
Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp Ala Glu Phe           
                710                 715                 720               

cag gag cgg ctc aaa gaa gat acg tct ttt ggg ggc aac ctc ggg cga       2266
Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly Asn Leu Gly Arg           
            725                 730                 735                   

gca gtc ttc cag gcc aaa aag agg ctt ctt gaa cct ctt ggt ctg gtt       2314
Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro Leu Gly Leu Val           
        740                 745                 750                       

gag gaa gcg gct aag acg gct cct gga aag aag agg cct gta gag cag       2362
Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro Val Glu Gln           
    755                 760                 765                           

tct cct cag gaa ccg gac tcc tcc gcg ggt att ggc aaa tcg ggt gca       2410
Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys Ser Gly Ala           
770                 775                 780                 785           

cag ccc gct aaa aag aga ctc aat ttc ggt cag act ggc gac aca gag       2458
Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Thr Glu           
                790                 795                 800               

tca gtc cca gac cct caa cca atc gga gaa cct ccc gca gcc ccc tca       2506
Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Ala Pro Ser           
            805                 810                 815                   

ggt gtg gga tct ctt aca atg gct tca ggt ggt ggc gca cca gtg gca       2554
Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala Pro Val Ala           
        820                 825                 830                       

gac aat aac gaa ggt gcc gat gga gtg ggt agt tcc tcg gga aat tgg       2602
Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp           
    835                 840                 845                           

cat tgc gat tcc caa tgg ctg ggg gac aga gtc atc acc acc agc acc       2650
His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr           
850                 855                 860                 865           

cga acc tgg gcc ctg ccc acc tac aac aat cac ctc tac aag caa atc       2698
Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile           
                870                 875                 880               

tcc aac agc aca tct gga gga tct tca aat gac aac gcc tac ttc ggc       2746
Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly           
            885                 890                 895                   

tac agc acc ccc tgg ggg tat ttt gac ttc aac aga ttc cac tgc cac       2794
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His           
        900                 905                 910                       

ttc tca cca cgt gac tgg cag cga ctc atc aac aac aac tgg gga ttc       2842
Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe           
    915                 920                 925                           

cgg cct aag cga ctc aac ttc aag ctc ttc aac att cag gtc aaa gag       2890
Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu           
930                 935                 940                 945           

gtt acg gac aac aat gga gtc aag acc atc gcc aat aac ctt acc agc       2938
Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser           
                950                 955                 960               

acg gtc cag gtc ttc acg gac tca gac tat cag ctc ccg tac gtg ctc       2986
Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu           
            965                 970                 975                   

ggg tcg gct cac gag ggc tgc ctc ccg ccg ttc cca gcg gac gtt ttc       3034
Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe           
        980                 985                 990                       

atg att cct cag tac ggg tat  ctg acg ctt aat gat  gga agc cag gcc     3082
Met Ile Pro Gln Tyr Gly Tyr  Leu Thr Leu Asn Asp  Gly Ser Gln Ala         
    995                 1000                 1005                         

gtg  ggt cgt tcg tcc ttt  tac tgc ctg gaa tat  ttc ccg tcg caa        3127
Val  Gly Arg Ser Ser Phe  Tyr Cys Leu Glu Tyr  Phe Pro Ser Gln            
1010                 1015                 1020                            

atg  cta aga acg ggt aac  aac ttc cag ttc agc  tac gag ttt gag        3172
Met  Leu Arg Thr Gly Asn  Asn Phe Gln Phe Ser  Tyr Glu Phe Glu            
1025                 1030                 1035                            

aac  gta cct ttc cat agc  agc tac gct cac agc  caa agc ctg gac        3217
Asn  Val Pro Phe His Ser  Ser Tyr Ala His Ser  Gln Ser Leu Asp            
1040                 1045                 1050                            

cga  cta atg aat cca ctc  atc gac caa tac ttg  tac tat ctc tca        3262
Arg  Leu Met Asn Pro Leu  Ile Asp Gln Tyr Leu  Tyr Tyr Leu Ser            
1055                 1060                 1065                            

aag  act att aac ggt tct  gga cag aat caa caa  acg cta aaa ttc        3307
Lys  Thr Ile Asn Gly Ser  Gly Gln Asn Gln Gln  Thr Leu Lys Phe            
1070                 1075                 1080                            

agt  gtg gcc gga ccc agc  aac atg gct gtc cag  gga aga aac tac        3352
Ser  Val Ala Gly Pro Ser  Asn Met Ala Val Gln  Gly Arg Asn Tyr            
1085                 1090                 1095                            

ata  cct gga ccc agc tac  cga caa caa cgt gtc  tca acc act gtg        3397
Ile  Pro Gly Pro Ser Tyr  Arg Gln Gln Arg Val  Ser Thr Thr Val            
1100                 1105                 1110                            

act  caa aac aac aac agc  gaa ttt gct tgg cct  gga gct tct tct        3442
Thr  Gln Asn Asn Asn Ser  Glu Phe Ala Trp Pro  Gly Ala Ser Ser            
1115                 1120                 1125                            

tgg  gct ctc aat gga cgt  aat agc ttg atg aat  cct gga cct gct        3487
Trp  Ala Leu Asn Gly Arg  Asn Ser Leu Met Asn  Pro Gly Pro Ala            
1130                 1135                 1140                            

atg  gcc agc cac aaa gaa  gga gag gac cgt ttc  ttt cct ttg tct        3532
Met  Ala Ser His Lys Glu  Gly Glu Asp Arg Phe  Phe Pro Leu Ser            
1145                 1150                 1155                            

gga  tct tta att ttt ggc  aaa caa gga act gga  aga gac aac gtg        3577
Gly  Ser Leu Ile Phe Gly  Lys Gln Gly Thr Gly  Arg Asp Asn Val            
1160                 1165                 1170                            

gat  gcg gac aaa gtc atg  ata acc aac gaa gaa  gaa att aaa act        3622
Asp  Ala Asp Lys Val Met  Ile Thr Asn Glu Glu  Glu Ile Lys Thr            
1175                 1180                 1185                            

act  aac ccg gta gca acg  gag tcc tat gga caa  gtg gcc aca aac        3667
Thr  Asn Pro Val Ala Thr  Glu Ser Tyr Gly Gln  Val Ala Thr Asn            
1190                 1195                 1200                            

cac  cag agt gcc caa gga  gga atc gag atc aac  gct acc aga gct        3712
His  Gln Ser Ala Gln Gly  Gly Ile Glu Ile Asn  Ala Thr Arg Ala            
1205                 1210                 1215                            

gga  acc aac ctg gga gga  gca cag gcg cag acc  ggc tgg gtt caa        3757
Gly  Thr Asn Leu Gly Gly  Ala Gln Ala Gln Thr  Gly Trp Val Gln            
1220                 1225                 1230                            

aac  caa gga ata ctt ccg  ggt atg gtt tgg cag  gac aga gat gtg        3802
Asn  Gln Gly Ile Leu Pro  Gly Met Val Trp Gln  Asp Arg Asp Val            
1235                 1240                 1245                            

tac  ctg caa gga ccc att  tgg gcc aaa att cct  cac acg gac ggc        3847
Tyr  Leu Gln Gly Pro Ile  Trp Ala Lys Ile Pro  His Thr Asp Gly            
1250                 1255                 1260                            

aac  ttt cac cct tct ccg  ctg atg gga ggg ttt  gga atg aag cac        3892
Asn  Phe His Pro Ser Pro  Leu Met Gly Gly Phe  Gly Met Lys His            
1265                 1270                 1275                            

ccg  cct cct cag atc ctc  atc aaa aac aca cct  gta cct gcg gat        3937
Pro  Pro Pro Gln Ile Leu  Ile Lys Asn Thr Pro  Val Pro Ala Asp            
1280                 1285                 1290                            

cct  cca acg gcc ttc aac  aag gac aag ctg aac  tct ttc atc acc        3982
Pro  Pro Thr Ala Phe Asn  Lys Asp Lys Leu Asn  Ser Phe Ile Thr            
1295                 1300                 1305                            

cag  tat tct act ggc caa  gtc agc gtg gag atc  gag tgg gag ctg        4027
Gln  Tyr Ser Thr Gly Gln  Val Ser Val Glu Ile  Glu Trp Glu Leu            
1310                 1315                 1320                            

cag  aag gaa aac agc aag  cgc tgg aac ccg gag  atc cag tac act        4072
Gln  Lys Glu Asn Ser Lys  Arg Trp Asn Pro Glu  Ile Gln Tyr Thr            
1325                 1330                 1335                            

tcc  aac tat tac aag tct  aat aat gtt gaa ttt  gct gtt aat act        4117
Ser  Asn Tyr Tyr Lys Ser  Asn Asn Val Glu Phe  Ala Val Asn Thr            
1340                 1345                 1350                            

gaa  ggt gta tat agt gaa  ccc cgc ccc att ggc  acc aga tac ctg        4162
Glu  Gly Val Tyr Ser Glu  Pro Arg Pro Ile Gly  Thr Arg Tyr Leu            
1355                 1360                 1365                            

act  cgt aat ctg taa ttgcttgtta atcaataaac cgtttaattc gtttcagttg      4217
Thr  Arg Asn Leu                                                          
1370                                                                      

aactttggtc tctgcgaagg gcgaattcgt ttaaacctgc aggactagag gtcctgtatt     4277

agaggtcacg tgagtgtttt gcgacatttt gcgacaccat gtggtcacgc tgggtattta     4337

agcccgagtg agcacgcagg gtctccattt tgaagcggga ggtttgaacg cgcagccgcc     4397

aagccgaatt ctgcagatat ccatcacact ggcggccgct cgactagagc ggccgccacc     4457

gcggtggagc tccagctttt gttcccttta gtgagggtta attgcgcgct tggcgtaatc     4517

atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg     4577

agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat     4637

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     4697

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgc                       4740


<210>  8
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210>  9
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Gly Gly Ile Glu 
            580                 585                 590         


Ile Asn Ala Thr Arg Ala Gly Thr Asn Leu Gly Gly Ala Gln Ala Gln 
        595                 600                 605             


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
    610                 615                 620                 


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
625                 630                 635                 640 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
                645                 650                 655     


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
            660                 665                 670         


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
        675                 680                 685             


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
    690                 695                 700                 


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
705                 710                 715                 720 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
                725                 730                 735     


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745                 750         


<210>  10
<211>  4722
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2/9 n.588.SAN nucleic acid sequence expression cassette


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  truncated promoter

<220>
<221>  promoter
<222>  (1)..(7)
<223>  p5 promoter

<220>
<221>  CDS
<222>  (37)..(1899)
<223>  AAV2 Rep

<220>
<221>  CDS
<222>  (1919)..(4159)
<223>  AAV 9 Cap

<220>
<221>  misc_feature
<222>  (3683)..(3712)
<223>  SAN

<220>
<221>  misc_feature
<222>  (4250)..(4380)
<223>  p5 promoter

<220>
<221>  misc_feature
<222>  (4508)..(4722)
<223>  LacZ promoter

<400>  10
ccattttgaa gcgggaggtt tgaacgcgca gccgcc atg ccg ggg ttt tac gag         54
                                        Met Pro Gly Phe Tyr Glu           
                                        1               5                 

att gtg att aag gtc ccc agc gac ctt gac gag cat ctg ccc ggc att        102
Ile Val Ile Lys Val Pro Ser Asp Leu Asp Glu His Leu Pro Gly Ile           
            10                  15                  20                    

tct gac agc ttt gtg aac tgg gtg gcc gag aag gaa tgg gag ttg ccg        150
Ser Asp Ser Phe Val Asn Trp Val Ala Glu Lys Glu Trp Glu Leu Pro           
        25                  30                  35                        

cca gat tct gac atg gat ctg aat ctg att gag cag gca ccc ctg acc        198
Pro Asp Ser Asp Met Asp Leu Asn Leu Ile Glu Gln Ala Pro Leu Thr           
    40                  45                  50                            

gtg gcc gag aag ctg cag cgc gac ttt ctg acg gaa tgg cgc cgt gtg        246
Val Ala Glu Lys Leu Gln Arg Asp Phe Leu Thr Glu Trp Arg Arg Val           
55                  60                  65                  70            

agt aag gcc ccg gag gct ctt ttc ttt gtg caa ttt gag aag gga gag        294
Ser Lys Ala Pro Glu Ala Leu Phe Phe Val Gln Phe Glu Lys Gly Glu           
                75                  80                  85                

agc tac ttc cac atg cac gtg ctc gtg gaa acc acc ggg gtg aaa tcc        342
Ser Tyr Phe His Met His Val Leu Val Glu Thr Thr Gly Val Lys Ser           
            90                  95                  100                   

atg gtt ttg gga cgt ttc ctg agt cag att cgc gaa aaa ctg att cag        390
Met Val Leu Gly Arg Phe Leu Ser Gln Ile Arg Glu Lys Leu Ile Gln           
        105                 110                 115                       

aga att tac cgc ggg atc gag ccg act ttg cca aac tgg ttc gcg gtc        438
Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu Pro Asn Trp Phe Ala Val           
    120                 125                 130                           

aca aag acc aga aat ggc gcc gga ggc ggg aac aag gtg gtg gat gag        486
Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly Asn Lys Val Val Asp Glu           
135                 140                 145                 150           

tgc tac atc ccc aat tac ttg ctc ccc aaa acc cag cct gag ctc cag        534
Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys Thr Gln Pro Glu Leu Gln           
                155                 160                 165               

tgg gcg tgg act aat atg gaa cag tat tta agc gcc tgt ttg aat ctc        582
Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu Ser Ala Cys Leu Asn Leu           
            170                 175                 180                   

acg gag cgt aaa cgg ttg gtg gcg cag cat ctg acg cac gtg tcg cag        630
Thr Glu Arg Lys Arg Leu Val Ala Gln His Leu Thr His Val Ser Gln           
        185                 190                 195                       

acg cag gag cag aac aaa gag aat cag aat ccc aat tct gat gcg ccg        678
Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn Pro Asn Ser Asp Ala Pro           
    200                 205                 210                           

gtg atc aga tca aaa act tca gcc agg tac atg gag ctg gtc ggg tgg        726
Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr Met Glu Leu Val Gly Trp           
215                 220                 225                 230           

ctc gtg gac aag ggg att acc tcg gag aag cag tgg atc cag gag gac        774
Leu Val Asp Lys Gly Ile Thr Ser Glu Lys Gln Trp Ile Gln Glu Asp           
                235                 240                 245               

cag gcc tca tac atc tcc ttc aat gcg gcc tcc aac tcg cgg tcc caa        822
Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala Ser Asn Ser Arg Ser Gln           
            250                 255                 260                   

atc aag gct gcc ttg gac aat gcg gga aag att atg agc ctg act aaa        870
Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys Ile Met Ser Leu Thr Lys           
        265                 270                 275                       

acc gcc ccc gac tac ctg gtg ggc cag cag ccc gtg gag gac att tcc        918
Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln Pro Val Glu Asp Ile Ser           
    280                 285                 290                           

agc aat cgg att tat aaa att ttg gaa cta aac ggg tac gat ccc caa        966
Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu Asn Gly Tyr Asp Pro Gln           
295                 300                 305                 310           

tat gcg gct tcc gtc ttt ctg gga tgg gcc acg aaa aag ttc ggc aag       1014
Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala Thr Lys Lys Phe Gly Lys           
                315                 320                 325               

agg aac acc atc tgg ctg ttt ggg cct gca act acc ggg aag acc aac       1062
Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala Thr Thr Gly Lys Thr Asn           
            330                 335                 340                   

atc gcg gag gcc ata gcc cac act gtg ccc ttc tac ggg tgc gta aac       1110
Ile Ala Glu Ala Ile Ala His Thr Val Pro Phe Tyr Gly Cys Val Asn           
        345                 350                 355                       

tgg acc aat gag aac ttt ccc ttc aac gac tgt gtc gac aag atg gtg       1158
Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys Val Asp Lys Met Val           
    360                 365                 370                           

atc tgg tgg gag gag ggg aag atg acc gcc aag gtc gtg gag tcg gcc       1206
Ile Trp Trp Glu Glu Gly Lys Met Thr Ala Lys Val Val Glu Ser Ala           
375                 380                 385                 390           

aaa gcc att ctc gga gga agc aag gtg cgc gtg gac cag aaa tgc aag       1254
Lys Ala Ile Leu Gly Gly Ser Lys Val Arg Val Asp Gln Lys Cys Lys           
                395                 400                 405               

tcc tcg gcc cag ata gac ccg act ccc gtg atc gtc acc tcc aac acc       1302
Ser Ser Ala Gln Ile Asp Pro Thr Pro Val Ile Val Thr Ser Asn Thr           
            410                 415                 420                   

aac atg tgc gcc gtg att gac ggg aac tca acg acc ttc gaa cac cag       1350
Asn Met Cys Ala Val Ile Asp Gly Asn Ser Thr Thr Phe Glu His Gln           
        425                 430                 435                       

cag ccg ttg caa gac cgg atg ttc aaa ttt gaa ctc acc cgc cgt ctg       1398
Gln Pro Leu Gln Asp Arg Met Phe Lys Phe Glu Leu Thr Arg Arg Leu           
    440                 445                 450                           

gat cat gac ttt ggg aag gtc acc aag cag gaa gtc aaa gac ttt ttc       1446
Asp His Asp Phe Gly Lys Val Thr Lys Gln Glu Val Lys Asp Phe Phe           
455                 460                 465                 470           

cgg tgg gca aag gat cac gtg gtt gag gtg gag cat gaa ttc tac gtc       1494
Arg Trp Ala Lys Asp His Val Val Glu Val Glu His Glu Phe Tyr Val           
                475                 480                 485               

aaa aag ggt gga gcc aag aaa aga ccc gcc ccc agt gac gca gat ata       1542
Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala Pro Ser Asp Ala Asp Ile           
            490                 495                 500                   

agt gag ccc aaa cgg gtg cgc gag tca gtt gcg cag cca tcg acg tca       1590
Ser Glu Pro Lys Arg Val Arg Glu Ser Val Ala Gln Pro Ser Thr Ser           
        505                 510                 515                       

gac gcg gaa gct tcg atc aac tac gca gac agg tac caa aac aaa tgt       1638
Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp Arg Tyr Gln Asn Lys Cys           
    520                 525                 530                           

tct cgt cac gtg ggc atg aat ctg atg ctg ttt ccc tgc aga caa tgc       1686
Ser Arg His Val Gly Met Asn Leu Met Leu Phe Pro Cys Arg Gln Cys           
535                 540                 545                 550           

gag aga atg aat cag aat tca aat atc tgc ttc act cac gga cag aaa       1734
Glu Arg Met Asn Gln Asn Ser Asn Ile Cys Phe Thr His Gly Gln Lys           
                555                 560                 565               

gac tgt tta gag tgc ttt ccc gtg tca gaa tct caa ccc gtt tct gtc       1782
Asp Cys Leu Glu Cys Phe Pro Val Ser Glu Ser Gln Pro Val Ser Val           
            570                 575                 580                   

gtc aaa aag gcg tat cag aaa ctg tgc tac att cat cat atc atg gga       1830
Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr Ile His His Ile Met Gly           
        585                 590                 595                       

aag gtg cca gac gct tgc act gcc tgc gat ctg gtc aat gtg gat ttg       1878
Lys Val Pro Asp Ala Cys Thr Ala Cys Asp Leu Val Asn Val Asp Leu           
    600                 605                 610                           

gat gac tgc atc ttt gaa caa taaatgattt aaatcaggt atg gct gcc gat      1930
Asp Asp Cys Ile Phe Glu Gln                      Met Ala Ala Asp          
615                 620                                      625          

ggt tat ctt cca gat tgg ctc gag gac aac ctt agt gaa gga att cgc       1978
Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu Gly Ile Arg           
                630                 635                 640               

gag tgg tgg gct ttg aaa cct gga gcc cct caa ccc aag gca aat caa       2026
Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro Lys Ala Asn Gln           
            645                 650                 655                   

caa cat caa gac aac gct cga ggt ctt gtg ctt ccg ggt tac aaa tac       2074
Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly Tyr Lys Tyr           
        660                 665                 670                       

ctt gga ccc ggc aac gga ctc gac aag ggg gag ccg gtc aac gca gca       2122
Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val Asn Ala Ala           
    675                 680                 685                           

gac gcg gcg gcc ctc gag cac gac aag gcc tac gac cag cag ctc aag       2170
Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln Gln Leu Lys           
690                 695                 700                 705           

gcc gga gac aac ccg tac ctc aag tac aac cac gcc gac gcc gag ttc       2218
Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp Ala Glu Phe           
                710                 715                 720               

cag gag cgg ctc aaa gaa gat acg tct ttt ggg ggc aac ctc ggg cga       2266
Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly Asn Leu Gly Arg           
            725                 730                 735                   

gca gtc ttc cag gcc aaa aag agg ctt ctt gaa cct ctt ggt ctg gtt       2314
Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro Leu Gly Leu Val           
        740                 745                 750                       

gag gaa gcg gct aag acg gct cct gga aag aag agg cct gta gag cag       2362
Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro Val Glu Gln           
    755                 760                 765                           

tct cct cag gaa ccg gac tcc tcc gcg ggt att ggc aaa tcg ggt gca       2410
Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys Ser Gly Ala           
770                 775                 780                 785           

cag ccc gct aaa aag aga ctc aat ttc ggt cag act ggc gac aca gag       2458
Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Thr Glu           
                790                 795                 800               

tca gtc cca gac cct caa cca atc gga gaa cct ccc gca gcc ccc tca       2506
Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Ala Pro Ser           
            805                 810                 815                   

ggt gtg gga tct ctt aca atg gct tca ggt ggt ggc gca cca gtg gca       2554
Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala Pro Val Ala           
        820                 825                 830                       

gac aat aac gaa ggt gcc gat gga gtg ggt agt tcc tcg gga aat tgg       2602
Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp           
    835                 840                 845                           

cat tgc gat tcc caa tgg ctg ggg gac aga gtc atc acc acc agc acc       2650
His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr           
850                 855                 860                 865           

cga acc tgg gcc ctg ccc acc tac aac aat cac ctc tac aag caa atc       2698
Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile           
                870                 875                 880               

tcc aac agc aca tct gga gga tct tca aat gac aac gcc tac ttc ggc       2746
Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly           
            885                 890                 895                   

tac agc acc ccc tgg ggg tat ttt gac ttc aac aga ttc cac tgc cac       2794
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His           
        900                 905                 910                       

ttc tca cca cgt gac tgg cag cga ctc atc aac aac aac tgg gga ttc       2842
Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe           
    915                 920                 925                           

cgg cct aag cga ctc aac ttc aag ctc ttc aac att cag gtc aaa gag       2890
Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu           
930                 935                 940                 945           

gtt acg gac aac aat gga gtc aag acc atc gcc aat aac ctt acc agc       2938
Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser           
                950                 955                 960               

acg gtc cag gtc ttc acg gac tca gac tat cag ctc ccg tac gtg ctc       2986
Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu           
            965                 970                 975                   

ggg tcg gct cac gag ggc tgc ctc ccg ccg ttc cca gcg gac gtt ttc       3034
Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe           
        980                 985                 990                       

atg att cct cag tac ggg tat  ctg acg ctt aat gat  gga agc cag gcc     3082
Met Ile Pro Gln Tyr Gly Tyr  Leu Thr Leu Asn Asp  Gly Ser Gln Ala         
    995                 1000                 1005                         

gtg  ggt cgt tcg tcc ttt  tac tgc ctg gaa tat  ttc ccg tcg caa        3127
Val  Gly Arg Ser Ser Phe  Tyr Cys Leu Glu Tyr  Phe Pro Ser Gln            
1010                 1015                 1020                            

atg  cta aga acg ggt aac  aac ttc cag ttc agc  tac gag ttt gag        3172
Met  Leu Arg Thr Gly Asn  Asn Phe Gln Phe Ser  Tyr Glu Phe Glu            
1025                 1030                 1035                            

aac  gta cct ttc cat agc  agc tac gct cac agc  caa agc ctg gac        3217
Asn  Val Pro Phe His Ser  Ser Tyr Ala His Ser  Gln Ser Leu Asp            
1040                 1045                 1050                            

cga  cta atg aat cca ctc  atc gac caa tac ttg  tac tat ctc tca        3262
Arg  Leu Met Asn Pro Leu  Ile Asp Gln Tyr Leu  Tyr Tyr Leu Ser            
1055                 1060                 1065                            

aag  act att aac ggt tct  gga cag aat caa caa  acg cta aaa ttc        3307
Lys  Thr Ile Asn Gly Ser  Gly Gln Asn Gln Gln  Thr Leu Lys Phe            
1070                 1075                 1080                            

agt  gtg gcc gga ccc agc  aac atg gct gtc cag  gga aga aac tac        3352
Ser  Val Ala Gly Pro Ser  Asn Met Ala Val Gln  Gly Arg Asn Tyr            
1085                 1090                 1095                            

ata  cct gga ccc agc tac  cga caa caa cgt gtc  tca acc act gtg        3397
Ile  Pro Gly Pro Ser Tyr  Arg Gln Gln Arg Val  Ser Thr Thr Val            
1100                 1105                 1110                            

act  caa aac aac aac agc  gaa ttt gct tgg cct  gga gct tct tct        3442
Thr  Gln Asn Asn Asn Ser  Glu Phe Ala Trp Pro  Gly Ala Ser Ser            
1115                 1120                 1125                            

tgg  gct ctc aat gga cgt  aat agc ttg atg aat  cct gga cct gct        3487
Trp  Ala Leu Asn Gly Arg  Asn Ser Leu Met Asn  Pro Gly Pro Ala            
1130                 1135                 1140                            

atg  gcc agc cac aaa gaa  gga gag gac cgt ttc  ttt cct ttg tct        3532
Met  Ala Ser His Lys Glu  Gly Glu Asp Arg Phe  Phe Pro Leu Ser            
1145                 1150                 1155                            

gga  tct tta att ttt ggc  aaa caa gga act gga  aga gac aac gtg        3577
Gly  Ser Leu Ile Phe Gly  Lys Gln Gly Thr Gly  Arg Asp Asn Val            
1160                 1165                 1170                            

gat  gcg gac aaa gtc atg  ata acc aac gaa gaa  gaa att aaa act        3622
Asp  Ala Asp Lys Val Met  Ile Thr Asn Glu Glu  Glu Ile Lys Thr            
1175                 1180                 1185                            

act  aac ccg gta gca acg  gag tcc tat gga caa  gtg gcc aca aac        3667
Thr  Asn Pro Val Ala Thr  Glu Ser Tyr Gly Gln  Val Ala Thr Asn            
1190                 1195                 1200                            

cac  cag agt gcc caa agc  gct aac ttc atc aag  cct acc agc tac        3712
His  Gln Ser Ala Gln Ser  Ala Asn Phe Ile Lys  Pro Thr Ser Tyr            
1205                 1210                 1215                            

gca  cag gcg cag acc ggc  tgg gtt caa aac caa  gga ata ctt ccg        3757
Ala  Gln Ala Gln Thr Gly  Trp Val Gln Asn Gln  Gly Ile Leu Pro            
1220                 1225                 1230                            

ggt  atg gtt tgg cag gac  aga gat gtg tac ctg  caa gga ccc att        3802
Gly  Met Val Trp Gln Asp  Arg Asp Val Tyr Leu  Gln Gly Pro Ile            
1235                 1240                 1245                            

tgg  gcc aaa att cct cac  acg gac ggc aac ttt  cac cct tct ccg        3847
Trp  Ala Lys Ile Pro His  Thr Asp Gly Asn Phe  His Pro Ser Pro            
1250                 1255                 1260                            

ctg  atg gga ggg ttt gga  atg aag cac ccg cct  cct cag atc ctc        3892
Leu  Met Gly Gly Phe Gly  Met Lys His Pro Pro  Pro Gln Ile Leu            
1265                 1270                 1275                            

atc  aaa aac aca cct gta  cct gcg gat cct cca  acg gcc ttc aac        3937
Ile  Lys Asn Thr Pro Val  Pro Ala Asp Pro Pro  Thr Ala Phe Asn            
1280                 1285                 1290                            

aag  gac aag ctg aac tct  ttc atc acc cag tat  tct act ggc caa        3982
Lys  Asp Lys Leu Asn Ser  Phe Ile Thr Gln Tyr  Ser Thr Gly Gln            
1295                 1300                 1305                            

gtc  agc gtg gag atc gag  tgg gag ctg cag aag  gaa aac agc aag        4027
Val  Ser Val Glu Ile Glu  Trp Glu Leu Gln Lys  Glu Asn Ser Lys            
1310                 1315                 1320                            

cgc  tgg aac ccg gag atc  cag tac act tcc aac  tat tac aag tct        4072
Arg  Trp Asn Pro Glu Ile  Gln Tyr Thr Ser Asn  Tyr Tyr Lys Ser            
1325                 1330                 1335                            

aat  aat gtt gaa ttt gct  gtt aat act gaa ggt  gta tat agt gaa        4117
Asn  Asn Val Glu Phe Ala  Val Asn Thr Glu Gly  Val Tyr Ser Glu            
1340                 1345                 1350                            

ccc  cgc ccc att ggc acc  aga tac ctg act cgt  aat ctg taa            4159
Pro  Arg Pro Ile Gly Thr  Arg Tyr Leu Thr Arg  Asn Leu                    
1355                 1360                 1365                            

ttgcttgtta atcaataaac cgtttaattc gtttcagttg aactttggtc tctgcgaagg     4219

gcgaattcgt ttaaacctgc aggactagag gtcctgtatt agaggtcacg tgagtgtttt     4279

gcgacatttt gcgacaccat gtggtcacgc tgggtattta agcccgagtg agcacgcagg     4339

gtctccattt tgaagcggga ggtttgaacg cgcagccgcc aagccgaatt ctgcagatat     4399

ccatcacact ggcggccgct cgactagagc ggccgccacc gcggtggagc tccagctttt     4459

gttcccttta gtgagggtta attgcgcgct tggcgtaatc atggtcatag ctgtttcctg     4519

tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta     4579

aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg     4639

ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga     4699

gaggcggttt gcgtattggg cgc                                             4722


<210>  11
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210>  12
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ser Ala Asn Phe 
            580                 585                 590         


Ile Lys Pro Thr Ser Tyr Ala Gln Ala Gln Thr Gly Trp Val Gln Asn 
        595                 600                 605             


Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu 
    610                 615                 620                 


Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His 
625                 630                 635                 640 


Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln 
                645                 650                 655     


Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe 
            660                 665                 670         


Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln 
        675                 680                 685             


Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg 
    690                 695                 700                 


Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn 
705                 710                 715                 720 


Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro 
                725                 730                 735     


Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745     


<210>  13
<211>  4725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2/9 n.588.SSN nucleic acid sequence expression cassette


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  trunctaed promoter

<220>
<221>  promoter
<222>  (1)..(7)
<223>  p5 promoter

<220>
<221>  CDS
<222>  (37)..(1899)
<223>  AAV2  Rep

<220>
<221>  CDS
<222>  (1919)..(4162)
<223>  AAV9 Cap

<220>
<221>  misc_feature
<222>  (3683)..(3715)
<223>  SSN

<220>
<221>  misc_feature
<222>  (4253)..(4383)
<223>  p5 promoter

<220>
<221>  misc_feature
<222>  (4511)..(4725)
<223>  LacZ promoter

<400>  13
ccattttgaa gcgggaggtt tgaacgcgca gccgcc atg ccg ggg ttt tac gag         54
                                        Met Pro Gly Phe Tyr Glu           
                                        1               5                 

att gtg att aag gtc ccc agc gac ctt gac gag cat ctg ccc ggc att        102
Ile Val Ile Lys Val Pro Ser Asp Leu Asp Glu His Leu Pro Gly Ile           
            10                  15                  20                    

tct gac agc ttt gtg aac tgg gtg gcc gag aag gaa tgg gag ttg ccg        150
Ser Asp Ser Phe Val Asn Trp Val Ala Glu Lys Glu Trp Glu Leu Pro           
        25                  30                  35                        

cca gat tct gac atg gat ctg aat ctg att gag cag gca ccc ctg acc        198
Pro Asp Ser Asp Met Asp Leu Asn Leu Ile Glu Gln Ala Pro Leu Thr           
    40                  45                  50                            

gtg gcc gag aag ctg cag cgc gac ttt ctg acg gaa tgg cgc cgt gtg        246
Val Ala Glu Lys Leu Gln Arg Asp Phe Leu Thr Glu Trp Arg Arg Val           
55                  60                  65                  70            

agt aag gcc ccg gag gct ctt ttc ttt gtg caa ttt gag aag gga gag        294
Ser Lys Ala Pro Glu Ala Leu Phe Phe Val Gln Phe Glu Lys Gly Glu           
                75                  80                  85                

agc tac ttc cac atg cac gtg ctc gtg gaa acc acc ggg gtg aaa tcc        342
Ser Tyr Phe His Met His Val Leu Val Glu Thr Thr Gly Val Lys Ser           
            90                  95                  100                   

atg gtt ttg gga cgt ttc ctg agt cag att cgc gaa aaa ctg att cag        390
Met Val Leu Gly Arg Phe Leu Ser Gln Ile Arg Glu Lys Leu Ile Gln           
        105                 110                 115                       

aga att tac cgc ggg atc gag ccg act ttg cca aac tgg ttc gcg gtc        438
Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu Pro Asn Trp Phe Ala Val           
    120                 125                 130                           

aca aag acc aga aat ggc gcc gga ggc ggg aac aag gtg gtg gat gag        486
Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly Asn Lys Val Val Asp Glu           
135                 140                 145                 150           

tgc tac atc ccc aat tac ttg ctc ccc aaa acc cag cct gag ctc cag        534
Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys Thr Gln Pro Glu Leu Gln           
                155                 160                 165               

tgg gcg tgg act aat atg gaa cag tat tta agc gcc tgt ttg aat ctc        582
Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu Ser Ala Cys Leu Asn Leu           
            170                 175                 180                   

acg gag cgt aaa cgg ttg gtg gcg cag cat ctg acg cac gtg tcg cag        630
Thr Glu Arg Lys Arg Leu Val Ala Gln His Leu Thr His Val Ser Gln           
        185                 190                 195                       

acg cag gag cag aac aaa gag aat cag aat ccc aat tct gat gcg ccg        678
Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn Pro Asn Ser Asp Ala Pro           
    200                 205                 210                           

gtg atc aga tca aaa act tca gcc agg tac atg gag ctg gtc ggg tgg        726
Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr Met Glu Leu Val Gly Trp           
215                 220                 225                 230           

ctc gtg gac aag ggg att acc tcg gag aag cag tgg atc cag gag gac        774
Leu Val Asp Lys Gly Ile Thr Ser Glu Lys Gln Trp Ile Gln Glu Asp           
                235                 240                 245               

cag gcc tca tac atc tcc ttc aat gcg gcc tcc aac tcg cgg tcc caa        822
Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala Ser Asn Ser Arg Ser Gln           
            250                 255                 260                   

atc aag gct gcc ttg gac aat gcg gga aag att atg agc ctg act aaa        870
Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys Ile Met Ser Leu Thr Lys           
        265                 270                 275                       

acc gcc ccc gac tac ctg gtg ggc cag cag ccc gtg gag gac att tcc        918
Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln Pro Val Glu Asp Ile Ser           
    280                 285                 290                           

agc aat cgg att tat aaa att ttg gaa cta aac ggg tac gat ccc caa        966
Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu Asn Gly Tyr Asp Pro Gln           
295                 300                 305                 310           

tat gcg gct tcc gtc ttt ctg gga tgg gcc acg aaa aag ttc ggc aag       1014
Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala Thr Lys Lys Phe Gly Lys           
                315                 320                 325               

agg aac acc atc tgg ctg ttt ggg cct gca act acc ggg aag acc aac       1062
Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala Thr Thr Gly Lys Thr Asn           
            330                 335                 340                   

atc gcg gag gcc ata gcc cac act gtg ccc ttc tac ggg tgc gta aac       1110
Ile Ala Glu Ala Ile Ala His Thr Val Pro Phe Tyr Gly Cys Val Asn           
        345                 350                 355                       

tgg acc aat gag aac ttt ccc ttc aac gac tgt gtc gac aag atg gtg       1158
Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys Val Asp Lys Met Val           
    360                 365                 370                           

atc tgg tgg gag gag ggg aag atg acc gcc aag gtc gtg gag tcg gcc       1206
Ile Trp Trp Glu Glu Gly Lys Met Thr Ala Lys Val Val Glu Ser Ala           
375                 380                 385                 390           

aaa gcc att ctc gga gga agc aag gtg cgc gtg gac cag aaa tgc aag       1254
Lys Ala Ile Leu Gly Gly Ser Lys Val Arg Val Asp Gln Lys Cys Lys           
                395                 400                 405               

tcc tcg gcc cag ata gac ccg act ccc gtg atc gtc acc tcc aac acc       1302
Ser Ser Ala Gln Ile Asp Pro Thr Pro Val Ile Val Thr Ser Asn Thr           
            410                 415                 420                   

aac atg tgc gcc gtg att gac ggg aac tca acg acc ttc gaa cac cag       1350
Asn Met Cys Ala Val Ile Asp Gly Asn Ser Thr Thr Phe Glu His Gln           
        425                 430                 435                       

cag ccg ttg caa gac cgg atg ttc aaa ttt gaa ctc acc cgc cgt ctg       1398
Gln Pro Leu Gln Asp Arg Met Phe Lys Phe Glu Leu Thr Arg Arg Leu           
    440                 445                 450                           

gat cat gac ttt ggg aag gtc acc aag cag gaa gtc aaa gac ttt ttc       1446
Asp His Asp Phe Gly Lys Val Thr Lys Gln Glu Val Lys Asp Phe Phe           
455                 460                 465                 470           

cgg tgg gca aag gat cac gtg gtt gag gtg gag cat gaa ttc tac gtc       1494
Arg Trp Ala Lys Asp His Val Val Glu Val Glu His Glu Phe Tyr Val           
                475                 480                 485               

aaa aag ggt gga gcc aag aaa aga ccc gcc ccc agt gac gca gat ata       1542
Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala Pro Ser Asp Ala Asp Ile           
            490                 495                 500                   

agt gag ccc aaa cgg gtg cgc gag tca gtt gcg cag cca tcg acg tca       1590
Ser Glu Pro Lys Arg Val Arg Glu Ser Val Ala Gln Pro Ser Thr Ser           
        505                 510                 515                       

gac gcg gaa gct tcg atc aac tac gca gac agg tac caa aac aaa tgt       1638
Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp Arg Tyr Gln Asn Lys Cys           
    520                 525                 530                           

tct cgt cac gtg ggc atg aat ctg atg ctg ttt ccc tgc aga caa tgc       1686
Ser Arg His Val Gly Met Asn Leu Met Leu Phe Pro Cys Arg Gln Cys           
535                 540                 545                 550           

gag aga atg aat cag aat tca aat atc tgc ttc act cac gga cag aaa       1734
Glu Arg Met Asn Gln Asn Ser Asn Ile Cys Phe Thr His Gly Gln Lys           
                555                 560                 565               

gac tgt tta gag tgc ttt ccc gtg tca gaa tct caa ccc gtt tct gtc       1782
Asp Cys Leu Glu Cys Phe Pro Val Ser Glu Ser Gln Pro Val Ser Val           
            570                 575                 580                   

gtc aaa aag gcg tat cag aaa ctg tgc tac att cat cat atc atg gga       1830
Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr Ile His His Ile Met Gly           
        585                 590                 595                       

aag gtg cca gac gct tgc act gcc tgc gat ctg gtc aat gtg gat ttg       1878
Lys Val Pro Asp Ala Cys Thr Ala Cys Asp Leu Val Asn Val Asp Leu           
    600                 605                 610                           

gat gac tgc atc ttt gaa caa taaatgattt aaatcaggt atg gct gcc gat      1930
Asp Asp Cys Ile Phe Glu Gln                      Met Ala Ala Asp          
615                 620                                      625          

ggt tat ctt cca gat tgg ctc gag gac aac ctt agt gaa gga att cgc       1978
Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu Gly Ile Arg           
                630                 635                 640               

gag tgg tgg gct ttg aaa cct gga gcc cct caa ccc aag gca aat caa       2026
Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro Lys Ala Asn Gln           
            645                 650                 655                   

caa cat caa gac aac gct cga ggt ctt gtg ctt ccg ggt tac aaa tac       2074
Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly Tyr Lys Tyr           
        660                 665                 670                       

ctt gga ccc ggc aac gga ctc gac aag ggg gag ccg gtc aac gca gca       2122
Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val Asn Ala Ala           
    675                 680                 685                           

gac gcg gcg gcc ctc gag cac gac aag gcc tac gac cag cag ctc aag       2170
Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln Gln Leu Lys           
690                 695                 700                 705           

gcc gga gac aac ccg tac ctc aag tac aac cac gcc gac gcc gag ttc       2218
Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp Ala Glu Phe           
                710                 715                 720               

cag gag cgg ctc aaa gaa gat acg tct ttt ggg ggc aac ctc ggg cga       2266
Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly Asn Leu Gly Arg           
            725                 730                 735                   

gca gtc ttc cag gcc aaa aag agg ctt ctt gaa cct ctt ggt ctg gtt       2314
Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro Leu Gly Leu Val           
        740                 745                 750                       

gag gaa gcg gct aag acg gct cct gga aag aag agg cct gta gag cag       2362
Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro Val Glu Gln           
    755                 760                 765                           

tct cct cag gaa ccg gac tcc tcc gcg ggt att ggc aaa tcg ggt gca       2410
Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys Ser Gly Ala           
770                 775                 780                 785           

cag ccc gct aaa aag aga ctc aat ttc ggt cag act ggc gac aca gag       2458
Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Thr Glu           
                790                 795                 800               

tca gtc cca gac cct caa cca atc gga gaa cct ccc gca gcc ccc tca       2506
Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Ala Pro Ser           
            805                 810                 815                   

ggt gtg gga tct ctt aca atg gct tca ggt ggt ggc gca cca gtg gca       2554
Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala Pro Val Ala           
        820                 825                 830                       

gac aat aac gaa ggt gcc gat gga gtg ggt agt tcc tcg gga aat tgg       2602
Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp           
    835                 840                 845                           

cat tgc gat tcc caa tgg ctg ggg gac aga gtc atc acc acc agc acc       2650
His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr           
850                 855                 860                 865           

cga acc tgg gcc ctg ccc acc tac aac aat cac ctc tac aag caa atc       2698
Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile           
                870                 875                 880               

tcc aac agc aca tct gga gga tct tca aat gac aac gcc tac ttc ggc       2746
Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly           
            885                 890                 895                   

tac agc acc ccc tgg ggg tat ttt gac ttc aac aga ttc cac tgc cac       2794
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His           
        900                 905                 910                       

ttc tca cca cgt gac tgg cag cga ctc atc aac aac aac tgg gga ttc       2842
Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe           
    915                 920                 925                           

cgg cct aag cga ctc aac ttc aag ctc ttc aac att cag gtc aaa gag       2890
Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu           
930                 935                 940                 945           

gtt acg gac aac aat gga gtc aag acc atc gcc aat aac ctt acc agc       2938
Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser           
                950                 955                 960               

acg gtc cag gtc ttc acg gac tca gac tat cag ctc ccg tac gtg ctc       2986
Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu           
            965                 970                 975                   

ggg tcg gct cac gag ggc tgc ctc ccg ccg ttc cca gcg gac gtt ttc       3034
Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe           
        980                 985                 990                       

atg att cct cag tac ggg tat  ctg acg ctt aat gat  gga agc cag gcc     3082
Met Ile Pro Gln Tyr Gly Tyr  Leu Thr Leu Asn Asp  Gly Ser Gln Ala         
    995                 1000                 1005                         

gtg  ggt cgt tcg tcc ttt  tac tgc ctg gaa tat  ttc ccg tcg caa        3127
Val  Gly Arg Ser Ser Phe  Tyr Cys Leu Glu Tyr  Phe Pro Ser Gln            
1010                 1015                 1020                            

atg  cta aga acg ggt aac  aac ttc cag ttc agc  tac gag ttt gag        3172
Met  Leu Arg Thr Gly Asn  Asn Phe Gln Phe Ser  Tyr Glu Phe Glu            
1025                 1030                 1035                            

aac  gta cct ttc cat agc  agc tac gct cac agc  caa agc ctg gac        3217
Asn  Val Pro Phe His Ser  Ser Tyr Ala His Ser  Gln Ser Leu Asp            
1040                 1045                 1050                            

cga  cta atg aat cca ctc  atc gac caa tac ttg  tac tat ctc tca        3262
Arg  Leu Met Asn Pro Leu  Ile Asp Gln Tyr Leu  Tyr Tyr Leu Ser            
1055                 1060                 1065                            

aag  act att aac ggt tct  gga cag aat caa caa  acg cta aaa ttc        3307
Lys  Thr Ile Asn Gly Ser  Gly Gln Asn Gln Gln  Thr Leu Lys Phe            
1070                 1075                 1080                            

agt  gtg gcc gga ccc agc  aac atg gct gtc cag  gga aga aac tac        3352
Ser  Val Ala Gly Pro Ser  Asn Met Ala Val Gln  Gly Arg Asn Tyr            
1085                 1090                 1095                            

ata  cct gga ccc agc tac  cga caa caa cgt gtc  tca acc act gtg        3397
Ile  Pro Gly Pro Ser Tyr  Arg Gln Gln Arg Val  Ser Thr Thr Val            
1100                 1105                 1110                            

act  caa aac aac aac agc  gaa ttt gct tgg cct  gga gct tct tct        3442
Thr  Gln Asn Asn Asn Ser  Glu Phe Ala Trp Pro  Gly Ala Ser Ser            
1115                 1120                 1125                            

tgg  gct ctc aat gga cgt  aat agc ttg atg aat  cct gga cct gct        3487
Trp  Ala Leu Asn Gly Arg  Asn Ser Leu Met Asn  Pro Gly Pro Ala            
1130                 1135                 1140                            

atg  gcc agc cac aaa gaa  gga gag gac cgt ttc  ttt cct ttg tct        3532
Met  Ala Ser His Lys Glu  Gly Glu Asp Arg Phe  Phe Pro Leu Ser            
1145                 1150                 1155                            

gga  tct tta att ttt ggc  aaa caa gga act gga  aga gac aac gtg        3577
Gly  Ser Leu Ile Phe Gly  Lys Gln Gly Thr Gly  Arg Asp Asn Val            
1160                 1165                 1170                            

gat  gcg gac aaa gtc atg  ata acc aac gaa gaa  gaa att aaa act        3622
Asp  Ala Asp Lys Val Met  Ile Thr Asn Glu Glu  Glu Ile Lys Thr            
1175                 1180                 1185                            

act  aac ccg gta gca acg  gag tcc tat gga caa  gtg gcc aca aac        3667
Thr  Asn Pro Val Ala Thr  Glu Ser Tyr Gly Gln  Val Ala Thr Asn            
1190                 1195                 1200                            

cac  cag agt gcc caa agc  agc aac acc gtg aag  ctg acc agc gga        3712
His  Gln Ser Ala Gln Ser  Ser Asn Thr Val Lys  Leu Thr Ser Gly            
1205                 1210                 1215                            

cac  gca cag gcg cag acc  ggc tgg gtt caa aac  caa gga ata ctt        3757
His  Ala Gln Ala Gln Thr  Gly Trp Val Gln Asn  Gln Gly Ile Leu            
1220                 1225                 1230                            

ccg  ggt atg gtt tgg cag  gac aga gat gtg tac  ctg caa gga ccc        3802
Pro  Gly Met Val Trp Gln  Asp Arg Asp Val Tyr  Leu Gln Gly Pro            
1235                 1240                 1245                            

att  tgg gcc aaa att cct  cac acg gac ggc aac  ttt cac cct tct        3847
Ile  Trp Ala Lys Ile Pro  His Thr Asp Gly Asn  Phe His Pro Ser            
1250                 1255                 1260                            

ccg  ctg atg gga ggg ttt  gga atg aag cac ccg  cct cct cag atc        3892
Pro  Leu Met Gly Gly Phe  Gly Met Lys His Pro  Pro Pro Gln Ile            
1265                 1270                 1275                            

ctc  atc aaa aac aca cct  gta cct gcg gat cct  cca acg gcc ttc        3937
Leu  Ile Lys Asn Thr Pro  Val Pro Ala Asp Pro  Pro Thr Ala Phe            
1280                 1285                 1290                            

aac  aag gac aag ctg aac  tct ttc atc acc cag  tat tct act ggc        3982
Asn  Lys Asp Lys Leu Asn  Ser Phe Ile Thr Gln  Tyr Ser Thr Gly            
1295                 1300                 1305                            

caa  gtc agc gtg gag atc  gag tgg gag ctg cag  aag gaa aac agc        4027
Gln  Val Ser Val Glu Ile  Glu Trp Glu Leu Gln  Lys Glu Asn Ser            
1310                 1315                 1320                            

aag  cgc tgg aac ccg gag  atc cag tac act tcc  aac tat tac aag        4072
Lys  Arg Trp Asn Pro Glu  Ile Gln Tyr Thr Ser  Asn Tyr Tyr Lys            
1325                 1330                 1335                            

tct  aat aat gtt gaa ttt  gct gtt aat act gaa  ggt gta tat agt        4117
Ser  Asn Asn Val Glu Phe  Ala Val Asn Thr Glu  Gly Val Tyr Ser            
1340                 1345                 1350                            

gaa  ccc cgc ccc att ggc  acc aga tac ctg act  cgt aat ctg taa        4162
Glu  Pro Arg Pro Ile Gly  Thr Arg Tyr Leu Thr  Arg Asn Leu                
1355                 1360                 1365                            

ttgcttgtta atcaataaac cgtttaattc gtttcagttg aactttggtc tctgcgaagg     4222

gcgaattcgt ttaaacctgc aggactagag gtcctgtatt agaggtcacg tgagtgtttt     4282

gcgacatttt gcgacaccat gtggtcacgc tgggtattta agcccgagtg agcacgcagg     4342

gtctccattt tgaagcggga ggtttgaacg cgcagccgcc aagccgaatt ctgcagatat     4402

ccatcacact ggcggccgct cgactagagc ggccgccacc gcggtggagc tccagctttt     4462

gttcccttta gtgagggtta attgcgcgct tggcgtaatc atggtcatag ctgtttcctg     4522

tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta     4582

aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg     4642

ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga     4702

gaggcggttt gcgtattggg cgc                                             4725


<210>  14
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210>  15
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ser Ser Asn Thr 
            580                 585                 590         


Val Lys Leu Thr Ser Gly His Ala Gln Ala Gln Thr Gly Trp Val Gln 
        595                 600                 605             


Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr 
    610                 615                 620                 


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
625                 630                 635                 640 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro 
                645                 650                 655     


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala 
            660                 665                 670         


Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
        675                 680                 685             


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
    690                 695                 700                 


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn 
705                 710                 715                 720 


Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg 
                725                 730                 735     


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745         


<210>  16
<211>  4737
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2/9 n.588.SSN-L nucleic acid sequence expression cassette


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  truncated promoter

<220>
<221>  promoter
<222>  (1)..(7)
<223>  p5 promoter

<220>
<221>  CDS
<222>  (37)..(1899)
<223>  AAV2 Rep

<220>
<221>  CDS
<222>  (1919)..(4174)
<223>  AAV9 Cap

<220>
<221>  misc_feature
<222>  (3683)..(3727)
<223>  SSN-L

<220>
<221>  misc_feature
<222>  (4253)..(4737)
<223>  LacZ promoter

<220>
<221>  misc_feature
<222>  (4265)..(4395)
<223>  p5 promoter

<400>  16
ccattttgaa gcgggaggtt tgaacgcgca gccgcc atg ccg ggg ttt tac gag         54
                                        Met Pro Gly Phe Tyr Glu           
                                        1               5                 

att gtg att aag gtc ccc agc gac ctt gac gag cat ctg ccc ggc att        102
Ile Val Ile Lys Val Pro Ser Asp Leu Asp Glu His Leu Pro Gly Ile           
            10                  15                  20                    

tct gac agc ttt gtg aac tgg gtg gcc gag aag gaa tgg gag ttg ccg        150
Ser Asp Ser Phe Val Asn Trp Val Ala Glu Lys Glu Trp Glu Leu Pro           
        25                  30                  35                        

cca gat tct gac atg gat ctg aat ctg att gag cag gca ccc ctg acc        198
Pro Asp Ser Asp Met Asp Leu Asn Leu Ile Glu Gln Ala Pro Leu Thr           
    40                  45                  50                            

gtg gcc gag aag ctg cag cgc gac ttt ctg acg gaa tgg cgc cgt gtg        246
Val Ala Glu Lys Leu Gln Arg Asp Phe Leu Thr Glu Trp Arg Arg Val           
55                  60                  65                  70            

agt aag gcc ccg gag gct ctt ttc ttt gtg caa ttt gag aag gga gag        294
Ser Lys Ala Pro Glu Ala Leu Phe Phe Val Gln Phe Glu Lys Gly Glu           
                75                  80                  85                

agc tac ttc cac atg cac gtg ctc gtg gaa acc acc ggg gtg aaa tcc        342
Ser Tyr Phe His Met His Val Leu Val Glu Thr Thr Gly Val Lys Ser           
            90                  95                  100                   

atg gtt ttg gga cgt ttc ctg agt cag att cgc gaa aaa ctg att cag        390
Met Val Leu Gly Arg Phe Leu Ser Gln Ile Arg Glu Lys Leu Ile Gln           
        105                 110                 115                       

aga att tac cgc ggg atc gag ccg act ttg cca aac tgg ttc gcg gtc        438
Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu Pro Asn Trp Phe Ala Val           
    120                 125                 130                           

aca aag acc aga aat ggc gcc gga ggc ggg aac aag gtg gtg gat gag        486
Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly Asn Lys Val Val Asp Glu           
135                 140                 145                 150           

tgc tac atc ccc aat tac ttg ctc ccc aaa acc cag cct gag ctc cag        534
Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys Thr Gln Pro Glu Leu Gln           
                155                 160                 165               

tgg gcg tgg act aat atg gaa cag tat tta agc gcc tgt ttg aat ctc        582
Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu Ser Ala Cys Leu Asn Leu           
            170                 175                 180                   

acg gag cgt aaa cgg ttg gtg gcg cag cat ctg acg cac gtg tcg cag        630
Thr Glu Arg Lys Arg Leu Val Ala Gln His Leu Thr His Val Ser Gln           
        185                 190                 195                       

acg cag gag cag aac aaa gag aat cag aat ccc aat tct gat gcg ccg        678
Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn Pro Asn Ser Asp Ala Pro           
    200                 205                 210                           

gtg atc aga tca aaa act tca gcc agg tac atg gag ctg gtc ggg tgg        726
Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr Met Glu Leu Val Gly Trp           
215                 220                 225                 230           

ctc gtg gac aag ggg att acc tcg gag aag cag tgg atc cag gag gac        774
Leu Val Asp Lys Gly Ile Thr Ser Glu Lys Gln Trp Ile Gln Glu Asp           
                235                 240                 245               

cag gcc tca tac atc tcc ttc aat gcg gcc tcc aac tcg cgg tcc caa        822
Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala Ser Asn Ser Arg Ser Gln           
            250                 255                 260                   

atc aag gct gcc ttg gac aat gcg gga aag att atg agc ctg act aaa        870
Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys Ile Met Ser Leu Thr Lys           
        265                 270                 275                       

acc gcc ccc gac tac ctg gtg ggc cag cag ccc gtg gag gac att tcc        918
Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln Pro Val Glu Asp Ile Ser           
    280                 285                 290                           

agc aat cgg att tat aaa att ttg gaa cta aac ggg tac gat ccc caa        966
Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu Asn Gly Tyr Asp Pro Gln           
295                 300                 305                 310           

tat gcg gct tcc gtc ttt ctg gga tgg gcc acg aaa aag ttc ggc aag       1014
Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala Thr Lys Lys Phe Gly Lys           
                315                 320                 325               

agg aac acc atc tgg ctg ttt ggg cct gca act acc ggg aag acc aac       1062
Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala Thr Thr Gly Lys Thr Asn           
            330                 335                 340                   

atc gcg gag gcc ata gcc cac act gtg ccc ttc tac ggg tgc gta aac       1110
Ile Ala Glu Ala Ile Ala His Thr Val Pro Phe Tyr Gly Cys Val Asn           
        345                 350                 355                       

tgg acc aat gag aac ttt ccc ttc aac gac tgt gtc gac aag atg gtg       1158
Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys Val Asp Lys Met Val           
    360                 365                 370                           

atc tgg tgg gag gag ggg aag atg acc gcc aag gtc gtg gag tcg gcc       1206
Ile Trp Trp Glu Glu Gly Lys Met Thr Ala Lys Val Val Glu Ser Ala           
375                 380                 385                 390           

aaa gcc att ctc gga gga agc aag gtg cgc gtg gac cag aaa tgc aag       1254
Lys Ala Ile Leu Gly Gly Ser Lys Val Arg Val Asp Gln Lys Cys Lys           
                395                 400                 405               

tcc tcg gcc cag ata gac ccg act ccc gtg atc gtc acc tcc aac acc       1302
Ser Ser Ala Gln Ile Asp Pro Thr Pro Val Ile Val Thr Ser Asn Thr           
            410                 415                 420                   

aac atg tgc gcc gtg att gac ggg aac tca acg acc ttc gaa cac cag       1350
Asn Met Cys Ala Val Ile Asp Gly Asn Ser Thr Thr Phe Glu His Gln           
        425                 430                 435                       

cag ccg ttg caa gac cgg atg ttc aaa ttt gaa ctc acc cgc cgt ctg       1398
Gln Pro Leu Gln Asp Arg Met Phe Lys Phe Glu Leu Thr Arg Arg Leu           
    440                 445                 450                           

gat cat gac ttt ggg aag gtc acc aag cag gaa gtc aaa gac ttt ttc       1446
Asp His Asp Phe Gly Lys Val Thr Lys Gln Glu Val Lys Asp Phe Phe           
455                 460                 465                 470           

cgg tgg gca aag gat cac gtg gtt gag gtg gag cat gaa ttc tac gtc       1494
Arg Trp Ala Lys Asp His Val Val Glu Val Glu His Glu Phe Tyr Val           
                475                 480                 485               

aaa aag ggt gga gcc aag aaa aga ccc gcc ccc agt gac gca gat ata       1542
Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala Pro Ser Asp Ala Asp Ile           
            490                 495                 500                   

agt gag ccc aaa cgg gtg cgc gag tca gtt gcg cag cca tcg acg tca       1590
Ser Glu Pro Lys Arg Val Arg Glu Ser Val Ala Gln Pro Ser Thr Ser           
        505                 510                 515                       

gac gcg gaa gct tcg atc aac tac gca gac agg tac caa aac aaa tgt       1638
Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp Arg Tyr Gln Asn Lys Cys           
    520                 525                 530                           

tct cgt cac gtg ggc atg aat ctg atg ctg ttt ccc tgc aga caa tgc       1686
Ser Arg His Val Gly Met Asn Leu Met Leu Phe Pro Cys Arg Gln Cys           
535                 540                 545                 550           

gag aga atg aat cag aat tca aat atc tgc ttc act cac gga cag aaa       1734
Glu Arg Met Asn Gln Asn Ser Asn Ile Cys Phe Thr His Gly Gln Lys           
                555                 560                 565               

gac tgt tta gag tgc ttt ccc gtg tca gaa tct caa ccc gtt tct gtc       1782
Asp Cys Leu Glu Cys Phe Pro Val Ser Glu Ser Gln Pro Val Ser Val           
            570                 575                 580                   

gtc aaa aag gcg tat cag aaa ctg tgc tac att cat cat atc atg gga       1830
Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr Ile His His Ile Met Gly           
        585                 590                 595                       

aag gtg cca gac gct tgc act gcc tgc gat ctg gtc aat gtg gat ttg       1878
Lys Val Pro Asp Ala Cys Thr Ala Cys Asp Leu Val Asn Val Asp Leu           
    600                 605                 610                           

gat gac tgc atc ttt gaa caa taaatgattt aaatcaggt atg gct gcc gat      1930
Asp Asp Cys Ile Phe Glu Gln                      Met Ala Ala Asp          
615                 620                                      625          

ggt tat ctt cca gat tgg ctc gag gac aac ctt agt gaa gga att cgc       1978
Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu Gly Ile Arg           
                630                 635                 640               

gag tgg tgg gct ttg aaa cct gga gcc cct caa ccc aag gca aat caa       2026
Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro Lys Ala Asn Gln           
            645                 650                 655                   

caa cat caa gac aac gct cga ggt ctt gtg ctt ccg ggt tac aaa tac       2074
Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly Tyr Lys Tyr           
        660                 665                 670                       

ctt gga ccc ggc aac gga ctc gac aag ggg gag ccg gtc aac gca gca       2122
Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val Asn Ala Ala           
    675                 680                 685                           

gac gcg gcg gcc ctc gag cac gac aag gcc tac gac cag cag ctc aag       2170
Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln Gln Leu Lys           
690                 695                 700                 705           

gcc gga gac aac ccg tac ctc aag tac aac cac gcc gac gcc gag ttc       2218
Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp Ala Glu Phe           
                710                 715                 720               

cag gag cgg ctc aaa gaa gat acg tct ttt ggg ggc aac ctc ggg cga       2266
Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly Asn Leu Gly Arg           
            725                 730                 735                   

gca gtc ttc cag gcc aaa aag agg ctt ctt gaa cct ctt ggt ctg gtt       2314
Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro Leu Gly Leu Val           
        740                 745                 750                       

gag gaa gcg gct aag acg gct cct gga aag aag agg cct gta gag cag       2362
Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro Val Glu Gln           
    755                 760                 765                           

tct cct cag gaa ccg gac tcc tcc gcg ggt att ggc aaa tcg ggt gca       2410
Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys Ser Gly Ala           
770                 775                 780                 785           

cag ccc gct aaa aag aga ctc aat ttc ggt cag act ggc gac aca gag       2458
Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Thr Glu           
                790                 795                 800               

tca gtc cca gac cct caa cca atc gga gaa cct ccc gca gcc ccc tca       2506
Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Ala Pro Ser           
            805                 810                 815                   

ggt gtg gga tct ctt aca atg gct tca ggt ggt ggc gca cca gtg gca       2554
Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala Pro Val Ala           
        820                 825                 830                       

gac aat aac gaa ggt gcc gat gga gtg ggt agt tcc tcg gga aat tgg       2602
Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp           
    835                 840                 845                           

cat tgc gat tcc caa tgg ctg ggg gac aga gtc atc acc acc agc acc       2650
His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr           
850                 855                 860                 865           

cga acc tgg gcc ctg ccc acc tac aac aat cac ctc tac aag caa atc       2698
Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile           
                870                 875                 880               

tcc aac agc aca tct gga gga tct tca aat gac aac gcc tac ttc ggc       2746
Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly           
            885                 890                 895                   

tac agc acc ccc tgg ggg tat ttt gac ttc aac aga ttc cac tgc cac       2794
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His           
        900                 905                 910                       

ttc tca cca cgt gac tgg cag cga ctc atc aac aac aac tgg gga ttc       2842
Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe           
    915                 920                 925                           

cgg cct aag cga ctc aac ttc aag ctc ttc aac att cag gtc aaa gag       2890
Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu           
930                 935                 940                 945           

gtt acg gac aac aat gga gtc aag acc atc gcc aat aac ctt acc agc       2938
Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser           
                950                 955                 960               

acg gtc cag gtc ttc acg gac tca gac tat cag ctc ccg tac gtg ctc       2986
Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu           
            965                 970                 975                   

ggg tcg gct cac gag ggc tgc ctc ccg ccg ttc cca gcg gac gtt ttc       3034
Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe           
        980                 985                 990                       

atg att cct cag tac ggg tat  ctg acg ctt aat gat  gga agc cag gcc     3082
Met Ile Pro Gln Tyr Gly Tyr  Leu Thr Leu Asn Asp  Gly Ser Gln Ala         
    995                 1000                 1005                         

gtg  ggt cgt tcg tcc ttt  tac tgc ctg gaa tat  ttc ccg tcg caa        3127
Val  Gly Arg Ser Ser Phe  Tyr Cys Leu Glu Tyr  Phe Pro Ser Gln            
1010                 1015                 1020                            

atg  cta aga acg ggt aac  aac ttc cag ttc agc  tac gag ttt gag        3172
Met  Leu Arg Thr Gly Asn  Asn Phe Gln Phe Ser  Tyr Glu Phe Glu            
1025                 1030                 1035                            

aac  gta cct ttc cat agc  agc tac gct cac agc  caa agc ctg gac        3217
Asn  Val Pro Phe His Ser  Ser Tyr Ala His Ser  Gln Ser Leu Asp            
1040                 1045                 1050                            

cga  cta atg aat cca ctc  atc gac caa tac ttg  tac tat ctc tca        3262
Arg  Leu Met Asn Pro Leu  Ile Asp Gln Tyr Leu  Tyr Tyr Leu Ser            
1055                 1060                 1065                            

aag  act att aac ggt tct  gga cag aat caa caa  acg cta aaa ttc        3307
Lys  Thr Ile Asn Gly Ser  Gly Gln Asn Gln Gln  Thr Leu Lys Phe            
1070                 1075                 1080                            

agt  gtg gcc gga ccc agc  aac atg gct gtc cag  gga aga aac tac        3352
Ser  Val Ala Gly Pro Ser  Asn Met Ala Val Gln  Gly Arg Asn Tyr            
1085                 1090                 1095                            

ata  cct gga ccc agc tac  cga caa caa cgt gtc  tca acc act gtg        3397
Ile  Pro Gly Pro Ser Tyr  Arg Gln Gln Arg Val  Ser Thr Thr Val            
1100                 1105                 1110                            

act  caa aac aac aac agc  gaa ttt gct tgg cct  gga gct tct tct        3442
Thr  Gln Asn Asn Asn Ser  Glu Phe Ala Trp Pro  Gly Ala Ser Ser            
1115                 1120                 1125                            

tgg  gct ctc aat gga cgt  aat agc ttg atg aat  cct gga cct gct        3487
Trp  Ala Leu Asn Gly Arg  Asn Ser Leu Met Asn  Pro Gly Pro Ala            
1130                 1135                 1140                            

atg  gcc agc cac aaa gaa  gga gag gac cgt ttc  ttt cct ttg tct        3532
Met  Ala Ser His Lys Glu  Gly Glu Asp Arg Phe  Phe Pro Leu Ser            
1145                 1150                 1155                            

gga  tct tta att ttt ggc  aaa caa gga act gga  aga gac aac gtg        3577
Gly  Ser Leu Ile Phe Gly  Lys Gln Gly Thr Gly  Arg Asp Asn Val            
1160                 1165                 1170                            

gat  gcg gac aaa gtc atg  ata acc aac gaa gaa  gaa att aaa act        3622
Asp  Ala Asp Lys Val Met  Ile Thr Asn Glu Glu  Glu Ile Lys Thr            
1175                 1180                 1185                            

act  aac ccg gta gca acg  gag tcc tat gga caa  gtg gcc aca aac        3667
Thr  Asn Pro Val Ala Thr  Glu Ser Tyr Gly Gln  Val Ala Thr Asn            
1190                 1195                 1200                            

cac  cag agt gcc caa gga  gga agc agc aac acc  gtg aag ctg acc        3712
His  Gln Ser Ala Gln Gly  Gly Ser Ser Asn Thr  Val Lys Leu Thr            
1205                 1210                 1215                            

agc  gga cac gga gga gca  cag gcg cag acc ggc  tgg gtt caa aac        3757
Ser  Gly His Gly Gly Ala  Gln Ala Gln Thr Gly  Trp Val Gln Asn            
1220                 1225                 1230                            

caa  gga ata ctt ccg ggt  atg gtt tgg cag gac  aga gat gtg tac        3802
Gln  Gly Ile Leu Pro Gly  Met Val Trp Gln Asp  Arg Asp Val Tyr            
1235                 1240                 1245                            

ctg  caa gga ccc att tgg  gcc aaa att cct cac  acg gac ggc aac        3847
Leu  Gln Gly Pro Ile Trp  Ala Lys Ile Pro His  Thr Asp Gly Asn            
1250                 1255                 1260                            

ttt  cac cct tct ccg ctg  atg gga ggg ttt gga  atg aag cac ccg        3892
Phe  His Pro Ser Pro Leu  Met Gly Gly Phe Gly  Met Lys His Pro            
1265                 1270                 1275                            

cct  cct cag atc ctc atc  aaa aac aca cct gta  cct gcg gat cct        3937
Pro  Pro Gln Ile Leu Ile  Lys Asn Thr Pro Val  Pro Ala Asp Pro            
1280                 1285                 1290                            

cca  acg gcc ttc aac aag  gac aag ctg aac tct  ttc atc acc cag        3982
Pro  Thr Ala Phe Asn Lys  Asp Lys Leu Asn Ser  Phe Ile Thr Gln            
1295                 1300                 1305                            

tat  tct act ggc caa gtc  agc gtg gag atc gag  tgg gag ctg cag        4027
Tyr  Ser Thr Gly Gln Val  Ser Val Glu Ile Glu  Trp Glu Leu Gln            
1310                 1315                 1320                            

aag  gaa aac agc aag cgc  tgg aac ccg gag atc  cag tac act tcc        4072
Lys  Glu Asn Ser Lys Arg  Trp Asn Pro Glu Ile  Gln Tyr Thr Ser            
1325                 1330                 1335                            

aac  tat tac aag tct aat  aat gtt gaa ttt gct  gtt aat act gaa        4117
Asn  Tyr Tyr Lys Ser Asn  Asn Val Glu Phe Ala  Val Asn Thr Glu            
1340                 1345                 1350                            

ggt  gta tat agt gaa ccc  cgc ccc att ggc acc  aga tac ctg act        4162
Gly  Val Tyr Ser Glu Pro  Arg Pro Ile Gly Thr  Arg Tyr Leu Thr            
1355                 1360                 1365                            

cgt  aat ctg taa ttgcttgtta atcaataaac cgtttaattc gtttcagttg          4214
Arg  Asn Leu                                                              
1370                                                                      

aactttggtc tctgcgaagg gcgaattcgt ttaaacctgc aggactagag gtcctgtatt     4274

agaggtcacg tgagtgtttt gcgacatttt gcgacaccat gtggtcacgc tgggtattta     4334

agcccgagtg agcacgcagg gtctccattt tgaagcggga ggtttgaacg cgcagccgcc     4394

aagccgaatt ctgcagatat ccatcacact ggcggccgct cgactagagc ggccgccacc     4454

gcggtggagc tccagctttt gttcccttta gtgagggtta attgcgcgct tggcgtaatc     4514

atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg     4574

agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat     4634

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     4694

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgc                       4737


<210>  17
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210>  18
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Gly Gly Ser Ser 
            580                 585                 590         


Asn Thr Val Lys Leu Thr Ser Gly His Gly Gly Ala Gln Ala Gln Thr 
        595                 600                 605             


Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
    610                 615                 620                 


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
625                 630                 635                 640 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys 
                645                 650                 655     


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp 
            660                 665                 670         


Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln 
        675                 680                 685             


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
    690                 695                 700                 


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
705                 710                 715                 720 


Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr 
                725                 730                 735     


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745                 750     


<210>  19
<211>  4740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2/9 n.588.VLT-L nucleic acid sequence expression cassette


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  truncated promoter

<220>
<221>  promoter
<222>  (1)..(7)
<223>  p5 promoter

<220>
<221>  CDS
<222>  (37)..(1899)
<223>  AAV2 Rep

<220>
<221>  CDS
<222>  (1919)..(4177)
<223>  AAV9 Cap

<220>
<221>  misc_feature
<222>  (3683)..(3730)
<223>  VLT-L

<220>
<221>  misc_feature
<222>  (4268)..(4398)
<223>  p5 promoter

<220>
<221>  misc_feature
<222>  (4526)..(4740)
<223>  LacZ promoter

<400>  19
ccattttgaa gcgggaggtt tgaacgcgca gccgcc atg ccg ggg ttt tac gag         54
                                        Met Pro Gly Phe Tyr Glu           
                                        1               5                 

att gtg att aag gtc ccc agc gac ctt gac gag cat ctg ccc ggc att        102
Ile Val Ile Lys Val Pro Ser Asp Leu Asp Glu His Leu Pro Gly Ile           
            10                  15                  20                    

tct gac agc ttt gtg aac tgg gtg gcc gag aag gaa tgg gag ttg ccg        150
Ser Asp Ser Phe Val Asn Trp Val Ala Glu Lys Glu Trp Glu Leu Pro           
        25                  30                  35                        

cca gat tct gac atg gat ctg aat ctg att gag cag gca ccc ctg acc        198
Pro Asp Ser Asp Met Asp Leu Asn Leu Ile Glu Gln Ala Pro Leu Thr           
    40                  45                  50                            

gtg gcc gag aag ctg cag cgc gac ttt ctg acg gaa tgg cgc cgt gtg        246
Val Ala Glu Lys Leu Gln Arg Asp Phe Leu Thr Glu Trp Arg Arg Val           
55                  60                  65                  70            

agt aag gcc ccg gag gct ctt ttc ttt gtg caa ttt gag aag gga gag        294
Ser Lys Ala Pro Glu Ala Leu Phe Phe Val Gln Phe Glu Lys Gly Glu           
                75                  80                  85                

agc tac ttc cac atg cac gtg ctc gtg gaa acc acc ggg gtg aaa tcc        342
Ser Tyr Phe His Met His Val Leu Val Glu Thr Thr Gly Val Lys Ser           
            90                  95                  100                   

atg gtt ttg gga cgt ttc ctg agt cag att cgc gaa aaa ctg att cag        390
Met Val Leu Gly Arg Phe Leu Ser Gln Ile Arg Glu Lys Leu Ile Gln           
        105                 110                 115                       

aga att tac cgc ggg atc gag ccg act ttg cca aac tgg ttc gcg gtc        438
Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu Pro Asn Trp Phe Ala Val           
    120                 125                 130                           

aca aag acc aga aat ggc gcc gga ggc ggg aac aag gtg gtg gat gag        486
Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly Asn Lys Val Val Asp Glu           
135                 140                 145                 150           

tgc tac atc ccc aat tac ttg ctc ccc aaa acc cag cct gag ctc cag        534
Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys Thr Gln Pro Glu Leu Gln           
                155                 160                 165               

tgg gcg tgg act aat atg gaa cag tat tta agc gcc tgt ttg aat ctc        582
Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu Ser Ala Cys Leu Asn Leu           
            170                 175                 180                   

acg gag cgt aaa cgg ttg gtg gcg cag cat ctg acg cac gtg tcg cag        630
Thr Glu Arg Lys Arg Leu Val Ala Gln His Leu Thr His Val Ser Gln           
        185                 190                 195                       

acg cag gag cag aac aaa gag aat cag aat ccc aat tct gat gcg ccg        678
Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn Pro Asn Ser Asp Ala Pro           
    200                 205                 210                           

gtg atc aga tca aaa act tca gcc agg tac atg gag ctg gtc ggg tgg        726
Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr Met Glu Leu Val Gly Trp           
215                 220                 225                 230           

ctc gtg gac aag ggg att acc tcg gag aag cag tgg atc cag gag gac        774
Leu Val Asp Lys Gly Ile Thr Ser Glu Lys Gln Trp Ile Gln Glu Asp           
                235                 240                 245               

cag gcc tca tac atc tcc ttc aat gcg gcc tcc aac tcg cgg tcc caa        822
Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala Ser Asn Ser Arg Ser Gln           
            250                 255                 260                   

atc aag gct gcc ttg gac aat gcg gga aag att atg agc ctg act aaa        870
Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys Ile Met Ser Leu Thr Lys           
        265                 270                 275                       

acc gcc ccc gac tac ctg gtg ggc cag cag ccc gtg gag gac att tcc        918
Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln Pro Val Glu Asp Ile Ser           
    280                 285                 290                           

agc aat cgg att tat aaa att ttg gaa cta aac ggg tac gat ccc caa        966
Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu Asn Gly Tyr Asp Pro Gln           
295                 300                 305                 310           

tat gcg gct tcc gtc ttt ctg gga tgg gcc acg aaa aag ttc ggc aag       1014
Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala Thr Lys Lys Phe Gly Lys           
                315                 320                 325               

agg aac acc atc tgg ctg ttt ggg cct gca act acc ggg aag acc aac       1062
Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala Thr Thr Gly Lys Thr Asn           
            330                 335                 340                   

atc gcg gag gcc ata gcc cac act gtg ccc ttc tac ggg tgc gta aac       1110
Ile Ala Glu Ala Ile Ala His Thr Val Pro Phe Tyr Gly Cys Val Asn           
        345                 350                 355                       

tgg acc aat gag aac ttt ccc ttc aac gac tgt gtc gac aag atg gtg       1158
Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys Val Asp Lys Met Val           
    360                 365                 370                           

atc tgg tgg gag gag ggg aag atg acc gcc aag gtc gtg gag tcg gcc       1206
Ile Trp Trp Glu Glu Gly Lys Met Thr Ala Lys Val Val Glu Ser Ala           
375                 380                 385                 390           

aaa gcc att ctc gga gga agc aag gtg cgc gtg gac cag aaa tgc aag       1254
Lys Ala Ile Leu Gly Gly Ser Lys Val Arg Val Asp Gln Lys Cys Lys           
                395                 400                 405               

tcc tcg gcc cag ata gac ccg act ccc gtg atc gtc acc tcc aac acc       1302
Ser Ser Ala Gln Ile Asp Pro Thr Pro Val Ile Val Thr Ser Asn Thr           
            410                 415                 420                   

aac atg tgc gcc gtg att gac ggg aac tca acg acc ttc gaa cac cag       1350
Asn Met Cys Ala Val Ile Asp Gly Asn Ser Thr Thr Phe Glu His Gln           
        425                 430                 435                       

cag ccg ttg caa gac cgg atg ttc aaa ttt gaa ctc acc cgc cgt ctg       1398
Gln Pro Leu Gln Asp Arg Met Phe Lys Phe Glu Leu Thr Arg Arg Leu           
    440                 445                 450                           

gat cat gac ttt ggg aag gtc acc aag cag gaa gtc aaa gac ttt ttc       1446
Asp His Asp Phe Gly Lys Val Thr Lys Gln Glu Val Lys Asp Phe Phe           
455                 460                 465                 470           

cgg tgg gca aag gat cac gtg gtt gag gtg gag cat gaa ttc tac gtc       1494
Arg Trp Ala Lys Asp His Val Val Glu Val Glu His Glu Phe Tyr Val           
                475                 480                 485               

aaa aag ggt gga gcc aag aaa aga ccc gcc ccc agt gac gca gat ata       1542
Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala Pro Ser Asp Ala Asp Ile           
            490                 495                 500                   

agt gag ccc aaa cgg gtg cgc gag tca gtt gcg cag cca tcg acg tca       1590
Ser Glu Pro Lys Arg Val Arg Glu Ser Val Ala Gln Pro Ser Thr Ser           
        505                 510                 515                       

gac gcg gaa gct tcg atc aac tac gca gac agg tac caa aac aaa tgt       1638
Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp Arg Tyr Gln Asn Lys Cys           
    520                 525                 530                           

tct cgt cac gtg ggc atg aat ctg atg ctg ttt ccc tgc aga caa tgc       1686
Ser Arg His Val Gly Met Asn Leu Met Leu Phe Pro Cys Arg Gln Cys           
535                 540                 545                 550           

gag aga atg aat cag aat tca aat atc tgc ttc act cac gga cag aaa       1734
Glu Arg Met Asn Gln Asn Ser Asn Ile Cys Phe Thr His Gly Gln Lys           
                555                 560                 565               

gac tgt tta gag tgc ttt ccc gtg tca gaa tct caa ccc gtt tct gtc       1782
Asp Cys Leu Glu Cys Phe Pro Val Ser Glu Ser Gln Pro Val Ser Val           
            570                 575                 580                   

gtc aaa aag gcg tat cag aaa ctg tgc tac att cat cat atc atg gga       1830
Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr Ile His His Ile Met Gly           
        585                 590                 595                       

aag gtg cca gac gct tgc act gcc tgc gat ctg gtc aat gtg gat ttg       1878
Lys Val Pro Asp Ala Cys Thr Ala Cys Asp Leu Val Asn Val Asp Leu           
    600                 605                 610                           

gat gac tgc atc ttt gaa caa taaatgattt aaatcaggt atg gct gcc gat      1930
Asp Asp Cys Ile Phe Glu Gln                      Met Ala Ala Asp          
615                 620                                      625          

ggt tat ctt cca gat tgg ctc gag gac aac ctt agt gaa gga att cgc       1978
Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu Gly Ile Arg           
                630                 635                 640               

gag tgg tgg gct ttg aaa cct gga gcc cct caa ccc aag gca aat caa       2026
Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro Lys Ala Asn Gln           
            645                 650                 655                   

caa cat caa gac aac gct cga ggt ctt gtg ctt ccg ggt tac aaa tac       2074
Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly Tyr Lys Tyr           
        660                 665                 670                       

ctt gga ccc ggc aac gga ctc gac aag ggg gag ccg gtc aac gca gca       2122
Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val Asn Ala Ala           
    675                 680                 685                           

gac gcg gcg gcc ctc gag cac gac aag gcc tac gac cag cag ctc aag       2170
Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln Gln Leu Lys           
690                 695                 700                 705           

gcc gga gac aac ccg tac ctc aag tac aac cac gcc gac gcc gag ttc       2218
Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp Ala Glu Phe           
                710                 715                 720               

cag gag cgg ctc aaa gaa gat acg tct ttt ggg ggc aac ctc ggg cga       2266
Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly Asn Leu Gly Arg           
            725                 730                 735                   

gca gtc ttc cag gcc aaa aag agg ctt ctt gaa cct ctt ggt ctg gtt       2314
Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro Leu Gly Leu Val           
        740                 745                 750                       

gag gaa gcg gct aag acg gct cct gga aag aag agg cct gta gag cag       2362
Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro Val Glu Gln           
    755                 760                 765                           

tct cct cag gaa ccg gac tcc tcc gcg ggt att ggc aaa tcg ggt gca       2410
Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys Ser Gly Ala           
770                 775                 780                 785           

cag ccc gct aaa aag aga ctc aat ttc ggt cag act ggc gac aca gag       2458
Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Thr Glu           
                790                 795                 800               

tca gtc cca gac cct caa cca atc gga gaa cct ccc gca gcc ccc tca       2506
Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Ala Pro Ser           
            805                 810                 815                   

ggt gtg gga tct ctt aca atg gct tca ggt ggt ggc gca cca gtg gca       2554
Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala Pro Val Ala           
        820                 825                 830                       

gac aat aac gaa ggt gcc gat gga gtg ggt agt tcc tcg gga aat tgg       2602
Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp           
    835                 840                 845                           

cat tgc gat tcc caa tgg ctg ggg gac aga gtc atc acc acc agc acc       2650
His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr           
850                 855                 860                 865           

cga acc tgg gcc ctg ccc acc tac aac aat cac ctc tac aag caa atc       2698
Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile           
                870                 875                 880               

tcc aac agc aca tct gga gga tct tca aat gac aac gcc tac ttc ggc       2746
Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly           
            885                 890                 895                   

tac agc acc ccc tgg ggg tat ttt gac ttc aac aga ttc cac tgc cac       2794
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His           
        900                 905                 910                       

ttc tca cca cgt gac tgg cag cga ctc atc aac aac aac tgg gga ttc       2842
Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe           
    915                 920                 925                           

cgg cct aag cga ctc aac ttc aag ctc ttc aac att cag gtc aaa gag       2890
Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu           
930                 935                 940                 945           

gtt acg gac aac aat gga gtc aag acc atc gcc aat aac ctt acc agc       2938
Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser           
                950                 955                 960               

acg gtc cag gtc ttc acg gac tca gac tat cag ctc ccg tac gtg ctc       2986
Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu           
            965                 970                 975                   

ggg tcg gct cac gag ggc tgc ctc ccg ccg ttc cca gcg gac gtt ttc       3034
Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe           
        980                 985                 990                       

atg att cct cag tac ggg tat  ctg acg ctt aat gat  gga agc cag gcc     3082
Met Ile Pro Gln Tyr Gly Tyr  Leu Thr Leu Asn Asp  Gly Ser Gln Ala         
    995                 1000                 1005                         

gtg  ggt cgt tcg tcc ttt  tac tgc ctg gaa tat  ttc ccg tcg caa        3127
Val  Gly Arg Ser Ser Phe  Tyr Cys Leu Glu Tyr  Phe Pro Ser Gln            
1010                 1015                 1020                            

atg  cta aga acg ggt aac  aac ttc cag ttc agc  tac gag ttt gag        3172
Met  Leu Arg Thr Gly Asn  Asn Phe Gln Phe Ser  Tyr Glu Phe Glu            
1025                 1030                 1035                            

aac  gta cct ttc cat agc  agc tac gct cac agc  caa agc ctg gac        3217
Asn  Val Pro Phe His Ser  Ser Tyr Ala His Ser  Gln Ser Leu Asp            
1040                 1045                 1050                            

cga  cta atg aat cca ctc  atc gac caa tac ttg  tac tat ctc tca        3262
Arg  Leu Met Asn Pro Leu  Ile Asp Gln Tyr Leu  Tyr Tyr Leu Ser            
1055                 1060                 1065                            

aag  act att aac ggt tct  gga cag aat caa caa  acg cta aaa ttc        3307
Lys  Thr Ile Asn Gly Ser  Gly Gln Asn Gln Gln  Thr Leu Lys Phe            
1070                 1075                 1080                            

agt  gtg gcc gga ccc agc  aac atg gct gtc cag  gga aga aac tac        3352
Ser  Val Ala Gly Pro Ser  Asn Met Ala Val Gln  Gly Arg Asn Tyr            
1085                 1090                 1095                            

ata  cct gga ccc agc tac  cga caa caa cgt gtc  tca acc act gtg        3397
Ile  Pro Gly Pro Ser Tyr  Arg Gln Gln Arg Val  Ser Thr Thr Val            
1100                 1105                 1110                            

act  caa aac aac aac agc  gaa ttt gct tgg cct  gga gct tct tct        3442
Thr  Gln Asn Asn Asn Ser  Glu Phe Ala Trp Pro  Gly Ala Ser Ser            
1115                 1120                 1125                            

tgg  gct ctc aat gga cgt  aat agc ttg atg aat  cct gga cct gct        3487
Trp  Ala Leu Asn Gly Arg  Asn Ser Leu Met Asn  Pro Gly Pro Ala            
1130                 1135                 1140                            

atg  gcc agc cac aaa gaa  gga gag gac cgt ttc  ttt cct ttg tct        3532
Met  Ala Ser His Lys Glu  Gly Glu Asp Arg Phe  Phe Pro Leu Ser            
1145                 1150                 1155                            

gga  tct tta att ttt ggc  aaa caa gga act gga  aga gac aac gtg        3577
Gly  Ser Leu Ile Phe Gly  Lys Gln Gly Thr Gly  Arg Asp Asn Val            
1160                 1165                 1170                            

gat  gcg gac aaa gtc atg  ata acc aac gaa gaa  gaa att aaa act        3622
Asp  Ala Asp Lys Val Met  Ile Thr Asn Glu Glu  Glu Ile Lys Thr            
1175                 1180                 1185                            

act  aac ccg gta gca acg  gag tcc tat gga caa  gtg gcc aca aac        3667
Thr  Asn Pro Val Ala Thr  Glu Ser Tyr Gly Gln  Val Ala Thr Asn            
1190                 1195                 1200                            

cac  cag agt gcc caa gga  gga gtg ctg acc aac  atc gct aga gga        3712
His  Gln Ser Ala Gln Gly  Gly Val Leu Thr Asn  Ile Ala Arg Gly            
1205                 1210                 1215                            

gag  tac atg aga gga gga  gca cag gcg cag acc  ggc tgg gtt caa        3757
Glu  Tyr Met Arg Gly Gly  Ala Gln Ala Gln Thr  Gly Trp Val Gln            
1220                 1225                 1230                            

aac  caa gga ata ctt ccg  ggt atg gtt tgg cag  gac aga gat gtg        3802
Asn  Gln Gly Ile Leu Pro  Gly Met Val Trp Gln  Asp Arg Asp Val            
1235                 1240                 1245                            

tac  ctg caa gga ccc att  tgg gcc aaa att cct  cac acg gac ggc        3847
Tyr  Leu Gln Gly Pro Ile  Trp Ala Lys Ile Pro  His Thr Asp Gly            
1250                 1255                 1260                            

aac  ttt cac cct tct ccg  ctg atg gga ggg ttt  gga atg aag cac        3892
Asn  Phe His Pro Ser Pro  Leu Met Gly Gly Phe  Gly Met Lys His            
1265                 1270                 1275                            

ccg  cct cct cag atc ctc  atc aaa aac aca cct  gta cct gcg gat        3937
Pro  Pro Pro Gln Ile Leu  Ile Lys Asn Thr Pro  Val Pro Ala Asp            
1280                 1285                 1290                            

cct  cca acg gcc ttc aac  aag gac aag ctg aac  tct ttc atc acc        3982
Pro  Pro Thr Ala Phe Asn  Lys Asp Lys Leu Asn  Ser Phe Ile Thr            
1295                 1300                 1305                            

cag  tat tct act ggc caa  gtc agc gtg gag atc  gag tgg gag ctg        4027
Gln  Tyr Ser Thr Gly Gln  Val Ser Val Glu Ile  Glu Trp Glu Leu            
1310                 1315                 1320                            

cag  aag gaa aac agc aag  cgc tgg aac ccg gag  atc cag tac act        4072
Gln  Lys Glu Asn Ser Lys  Arg Trp Asn Pro Glu  Ile Gln Tyr Thr            
1325                 1330                 1335                            

tcc  aac tat tac aag tct  aat aat gtt gaa ttt  gct gtt aat act        4117
Ser  Asn Tyr Tyr Lys Ser  Asn Asn Val Glu Phe  Ala Val Asn Thr            
1340                 1345                 1350                            

gaa  ggt gta tat agt gaa  ccc cgc ccc att ggc  acc aga tac ctg        4162
Glu  Gly Val Tyr Ser Glu  Pro Arg Pro Ile Gly  Thr Arg Tyr Leu            
1355                 1360                 1365                            

act  cgt aat ctg taa ttgcttgtta atcaataaac cgtttaattc gtttcagttg      4217
Thr  Arg Asn Leu                                                          
1370                                                                      

aactttggtc tctgcgaagg gcgaattcgt ttaaacctgc aggactagag gtcctgtatt     4277

agaggtcacg tgagtgtttt gcgacatttt gcgacaccat gtggtcacgc tgggtattta     4337

agcccgagtg agcacgcagg gtctccattt tgaagcggga ggtttgaacg cgcagccgcc     4397

aagccgaatt ctgcagatat ccatcacact ggcggccgct cgactagagc ggccgccacc     4457

gcggtggagc tccagctttt gttcccttta gtgagggtta attgcgcgct tggcgtaatc     4517

atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg     4577

agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat     4637

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     4697

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgc                       4740


<210>  20
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210>  21
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Gly Gly Val Leu 
            580                 585                 590         


Thr Asn Ile Ala Arg Gly Glu Tyr Met Arg Gly Gly Ala Gln Ala Gln 
        595                 600                 605             


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
    610                 615                 620                 


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
625                 630                 635                 640 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
                645                 650                 655     


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
            660                 665                 670         


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
        675                 680                 685             


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
    690                 695                 700                 


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
705                 710                 715                 720 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
                725                 730                 735     


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745                 750         


<210>  22
<211>  1863
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 Rep nucleic acid sequence

<400>  22
atgccggggt tttacgagat tgtgattaag gtccccagcg accttgacga gcatctgccc       60

ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat      120

tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag      180

cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggctct tttctttgtg      240

caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg      300

aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt      360

taccgcggga tcgagccgac tttgccaaac tggttcgcgg tcacaaagac cagaaatggc      420

gccggaggcg ggaacaaggt ggtggatgag tgctacatcc ccaattactt gctccccaaa      480

acccagcctg agctccagtg ggcgtggact aatatggaac agtatttaag cgcctgtttg      540

aatctcacgg agcgtaaacg gttggtggcg cagcatctga cgcacgtgtc gcagacgcag      600

gagcagaaca aagagaatca gaatcccaat tctgatgcgc cggtgatcag atcaaaaact      660

tcagccaggt acatggagct ggtcgggtgg ctcgtggaca aggggattac ctcggagaag      720

cagtggatcc aggaggacca ggcctcatac atctccttca atgcggcctc caactcgcgg      780

tcccaaatca aggctgcctt ggacaatgcg ggaaagatta tgagcctgac taaaaccgcc      840

cccgactacc tggtgggcca gcagcccgtg gaggacattt ccagcaatcg gatttataaa      900

attttggaac taaacgggta cgatccccaa tatgcggctt ccgtctttct gggatgggcc      960

acgaaaaagt tcggcaagag gaacaccatc tggctgtttg ggcctgcaac taccgggaag     1020

accaacatcg cggaggccat agcccacact gtgcccttct acgggtgcgt aaactggacc     1080

aatgagaact ttcccttcaa cgactgtgtc gacaagatgg tgatctggtg ggaggagggg     1140

aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc tcggaggaag caaggtgcgc     1200

gtggaccaga aatgcaagtc ctcggcccag atagacccga ctcccgtgat cgtcacctcc     1260

aacaccaaca tgtgcgccgt gattgacggg aactcaacga ccttcgaaca ccagcagccg     1320

ttgcaagacc ggatgttcaa atttgaactc acccgccgtc tggatcatga ctttgggaag     1380

gtcaccaagc aggaagtcaa agactttttc cggtgggcaa aggatcacgt ggttgaggtg     1440

gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa gacccgcccc cagtgacgca     1500

gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc agccatcgac gtcagacgcg     1560

gaagcttcga tcaactacgc agacaggtac caaaacaaat gttctcgtca cgtgggcatg     1620

aatctgatgc tgtttccctg cagacaatgc gagagaatga atcagaattc aaatatctgc     1680

ttcactcacg gacagaaaga ctgtttagag tgctttcccg tgtcagaatc tcaacccgtt     1740

tctgtcgtca aaaaggcgta tcagaaactg tgctacattc atcatatcat gggaaaggtg     1800

ccagacgctt gcactgcctg cgatctggtc aatgtggatt tggatgactg catctttgaa     1860

caa                                                                   1863


<210>  23
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV2 Rep amino acid sequence

<400>  23

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210>  24
<211>  2244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9 Cap n.588.EFS nucleic acid sequence


<220>
<221>  misc_feature
<222>  (1765)..(1797)
<223>  EFS

<400>  24
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagagttc agcagcaaca ccgtgaagct gaccagcgca     1800

caggcgcaga ccggctgggt tcaaaaccaa ggaatacttc cgggtatggt ttggcaggac     1860

agagatgtgt acctgcaagg acccatttgg gccaaaattc ctcacacgga cggcaacttt     1920

cacccttctc cgctgatggg agggtttgga atgaagcacc cgcctcctca gatcctcatc     1980

aaaaacacac ctgtacctgc ggatcctcca acggccttca acaaggacaa gctgaactct     2040

ttcatcaccc agtattctac tggccaagtc agcgtggaga tcgagtggga gctgcagaag     2100

gaaaacagca agcgctggaa cccggagatc cagtacactt ccaactatta caagtctaat     2160

aatgttgaat ttgctgttaa tactgaaggt gtatatagtg aaccccgccc cattggcacc     2220

agatacctga ctcgtaatct gtaa                                            2244


<210>  25
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV9 Cap n.588.EFS amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (499)..(599)
<223>  EFS

<400>  25

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Glu Phe Ser Ser 
            580                 585                 590         


Asn Thr Val Lys Leu Thr Ser Ala Gln Ala Gln Thr Gly Trp Val Gln 
        595                 600                 605             


Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr 
    610                 615                 620                 


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
625                 630                 635                 640 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro 
                645                 650                 655     


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala 
            660                 665                 670         


Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
        675                 680                 685             


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
    690                 695                 700                 


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn 
705                 710                 715                 720 


Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg 
                725                 730                 735     


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745         


<210>  26
<211>  2247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9 Cap n588.IEI nucleic acid sequence


<220>
<221>  misc_feature
<222>  (1765)..(1800)
<223>  IEI

<400>  26
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaaatcgag atcaacgcta ccagagctgg aaccaacctg     1800

gcacaggcgc agaccggctg ggttcaaaac caaggaatac ttccgggtat ggtttggcag     1860

gacagagatg tgtacctgca aggacccatt tgggccaaaa ttcctcacac ggacggcaac     1920

tttcaccctt ctccgctgat gggagggttt ggaatgaagc acccgcctcc tcagatcctc     1980

atcaaaaaca cacctgtacc tgcggatcct ccaacggcct tcaacaagga caagctgaac     2040

tctttcatca cccagtattc tactggccaa gtcagcgtgg agatcgagtg ggagctgcag     2100

aaggaaaaca gcaagcgctg gaacccggag atccagtaca cttccaacta ttacaagtct     2160

aataatgttg aatttgctgt taatactgaa ggtgtatata gtgaaccccg ccccattggc     2220

accagatacc tgactcgtaa tctgtaa                                         2247


<210>  27
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV9 Cap n588.IEI amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (499)..(600)
<223>  IEI

<400>  27

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ile Glu Ile Asn 
            580                 585                 590         


Ala Thr Arg Ala Gly Thr Asn Leu Ala Gln Ala Gln Thr Gly Trp Val 
        595                 600                 605             


Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val 
    610                 615                 620                 


Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn 
625                 630                 635                 640 


Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His Pro Pro 
                645                 650                 655     


Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr 
            660                 665                 670         


Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr 
        675                 680                 685             


Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser 
    690                 695                 700                 


Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser 
705                 710                 715                 720 


Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro 
                725                 730                 735     


Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745             


<210>  28
<211>  2259
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9 Cap n.588.IEI-L nucleic acid sequence


<220>
<221>  misc_feature
<222>  (1765)..(1812)
<223>  IEI-L

<400>  28
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaaggagga atcgagatca acgctaccag agctggaacc     1800

aacctgggag gagcacaggc gcagaccggc tgggttcaaa accaaggaat acttccgggt     1860

atggtttggc aggacagaga tgtgtacctg caaggaccca tttgggccaa aattcctcac     1920

acggacggca actttcaccc ttctccgctg atgggagggt ttggaatgaa gcacccgcct     1980

cctcagatcc tcatcaaaaa cacacctgta cctgcggatc ctccaacggc cttcaacaag     2040

gacaagctga actctttcat cacccagtat tctactggcc aagtcagcgt ggagatcgag     2100

tgggagctgc agaaggaaaa cagcaagcgc tggaacccgg agatccagta cacttccaac     2160

tattacaagt ctaataatgt tgaatttgct gttaatactg aaggtgtata tagtgaaccc     2220

cgccccattg gcaccagata cctgactcgt aatctgtaa                            2259


<210>  29
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV9 Cap n.588.IEI-L amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (499)..(604)
<223>  IEI-L

<400>  29

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Gly Gly Ile Glu 
            580                 585                 590         


Ile Asn Ala Thr Arg Ala Gly Thr Asn Leu Gly Gly Ala Gln Ala Gln 
        595                 600                 605             


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
    610                 615                 620                 


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
625                 630                 635                 640 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
                645                 650                 655     


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
            660                 665                 670         


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
        675                 680                 685             


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
    690                 695                 700                 


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
705                 710                 715                 720 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
                725                 730                 735     


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745                 750         


<210>  30
<211>  2241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9 Cap n.588.SAN nucleic acid sequence


<220>
<221>  misc_feature
<222>  (1765)..(1794)
<223>  SAN

<400>  30
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaaagcgct aacttcatca agcctaccag ctacgcacag     1800

gcgcagaccg gctgggttca aaaccaagga atacttccgg gtatggtttg gcaggacaga     1860

gatgtgtacc tgcaaggacc catttgggcc aaaattcctc acacggacgg caactttcac     1920

ccttctccgc tgatgggagg gtttggaatg aagcacccgc ctcctcagat cctcatcaaa     1980

aacacacctg tacctgcgga tcctccaacg gccttcaaca aggacaagct gaactctttc     2040

atcacccagt attctactgg ccaagtcagc gtggagatcg agtgggagct gcagaaggaa     2100

aacagcaagc gctggaaccc ggagatccag tacacttcca actattacaa gtctaataat     2160

gttgaatttg ctgttaatac tgaaggtgta tatagtgaac cccgccccat tggcaccaga     2220

tacctgactc gtaatctgta a                                               2241


<210>  31
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV9 Cap n.588.SAN amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (499)..(598)
<223>  SAN

<400>  31

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ser Ala Asn Phe 
            580                 585                 590         


Ile Lys Pro Thr Ser Tyr Ala Gln Ala Gln Thr Gly Trp Val Gln Asn 
        595                 600                 605             


Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu 
    610                 615                 620                 


Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His 
625                 630                 635                 640 


Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln 
                645                 650                 655     


Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe 
            660                 665                 670         


Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln 
        675                 680                 685             


Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg 
    690                 695                 700                 


Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn 
705                 710                 715                 720 


Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro 
                725                 730                 735     


Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745     


<210>  32
<211>  2244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9 Cap n.588.SSN nucleic acid sequence


<220>
<221>  misc_feature
<222>  (1765)..(1797)
<223>  SSN

<400>  32
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaaagcagc aacaccgtga agctgaccag cggacacgca     1800

caggcgcaga ccggctgggt tcaaaaccaa ggaatacttc cgggtatggt ttggcaggac     1860

agagatgtgt acctgcaagg acccatttgg gccaaaattc ctcacacgga cggcaacttt     1920

cacccttctc cgctgatggg agggtttgga atgaagcacc cgcctcctca gatcctcatc     1980

aaaaacacac ctgtacctgc ggatcctcca acggccttca acaaggacaa gctgaactct     2040

ttcatcaccc agtattctac tggccaagtc agcgtggaga tcgagtggga gctgcagaag     2100

gaaaacagca agcgctggaa cccggagatc cagtacactt ccaactatta caagtctaat     2160

aatgttgaat ttgctgttaa tactgaaggt gtatatagtg aaccccgccc cattggcacc     2220

agatacctga ctcgtaatct gtaa                                            2244


<210>  33
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV9 Cap n.588.SSN amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (499)..(599)
<223>  SSN

<400>  33

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ser Ser Asn Thr 
            580                 585                 590         


Val Lys Leu Thr Ser Gly His Ala Gln Ala Gln Thr Gly Trp Val Gln 
        595                 600                 605             


Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr 
    610                 615                 620                 


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
625                 630                 635                 640 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro 
                645                 650                 655     


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala 
            660                 665                 670         


Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
        675                 680                 685             


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
    690                 695                 700                 


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn 
705                 710                 715                 720 


Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg 
                725                 730                 735     


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745         


<210>  34
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9 Cap n.588.SSN-L nucleic acid sequence


<220>
<221>  misc_feature
<222>  (1765)..(1809)
<223>  SSN-L

<400>  34
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaaggagga agcagcaaca ccgtgaagct gaccagcgga     1800

cacggaggag cacaggcgca gaccggctgg gttcaaaacc aaggaatact tccgggtatg     1860

gtttggcagg acagagatgt gtacctgcaa ggacccattt gggccaaaat tcctcacacg     1920

gacggcaact ttcacccttc tccgctgatg ggagggtttg gaatgaagca cccgcctcct     1980

cagatcctca tcaaaaacac acctgtacct gcggatcctc caacggcctt caacaaggac     2040

aagctgaact ctttcatcac ccagtattct actggccaag tcagcgtgga gatcgagtgg     2100

gagctgcaga aggaaaacag caagcgctgg aacccggaga tccagtacac ttccaactat     2160

tacaagtcta ataatgttga atttgctgtt aatactgaag gtgtatatag tgaaccccgc     2220

cccattggca ccagatacct gactcgtaat ctgtaa                               2256


<210>  35
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV9 Cap n.588.SSN-L amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (499)..(603)
<223>  SSN-L

<400>  35

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Gly Gly Ser Ser 
            580                 585                 590         


Asn Thr Val Lys Leu Thr Ser Gly His Gly Gly Ala Gln Ala Gln Thr 
        595                 600                 605             


Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
    610                 615                 620                 


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
625                 630                 635                 640 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys 
                645                 650                 655     


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp 
            660                 665                 670         


Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln 
        675                 680                 685             


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
    690                 695                 700                 


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
705                 710                 715                 720 


Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr 
                725                 730                 735     


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745                 750     


<210>  36
<211>  2259
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9 Cap n588.VLT-L nucleic acid sequence


<220>
<221>  misc_feature
<222>  (1765)..(1812)
<223>  VLT-L

<400>  36
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaaggagga gtgctgacca acatcgctag aggagagtac     1800

atgagaggag gagcacaggc gcagaccggc tgggttcaaa accaaggaat acttccgggt     1860

atggtttggc aggacagaga tgtgtacctg caaggaccca tttgggccaa aattcctcac     1920

acggacggca actttcaccc ttctccgctg atgggagggt ttggaatgaa gcacccgcct     1980

cctcagatcc tcatcaaaaa cacacctgta cctgcggatc ctccaacggc cttcaacaag     2040

gacaagctga actctttcat cacccagtat tctactggcc aagtcagcgt ggagatcgag     2100

tgggagctgc agaaggaaaa cagcaagcgc tggaacccgg agatccagta cacttccaac     2160

tattacaagt ctaataatgt tgaatttgct gttaatactg aaggtgtata tagtgaaccc     2220

cgccccattg gcaccagata cctgactcgt aatctgtaa                            2259


<210>  37
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV9 Cap n588.VLT-L amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (499)..(604)
<223>  VLT-L

<400>  37

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Gly Gly Val Leu 
            580                 585                 590         


Thr Asn Ile Ala Arg Gly Glu Tyr Met Arg Gly Gly Ala Gln Ala Gln 
        595                 600                 605             


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
    610                 615                 620                 


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
625                 630                 635                 640 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
                645                 650                 655     


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
            660                 665                 670         


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
        675                 680                 685             


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
    690                 695                 700                 


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
705                 710                 715                 720 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
                725                 730                 735     


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745                 750         


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFS peptide sequence

<400>  38

Glu Phe Ser Ser Asn Thr Val Lys Leu Thr Ser 
1               5                   10      


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SSN-L peptide sequence

<400>  39

Gly Gly Ser Ser Asn Thr Val Lys Leu Thr Ser Gly His Gly Gly 
1               5                   10                  15  


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SSN peptide sequence

<400>  40

Ser Ser Asn Thr Val Lys Leu Thr Ser Gly His 
1               5                   10      


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAN peptide sequence

<400>  41

Ser Ala Asn Phe Ile Lys Pro Thr Ser Tyr 
1               5                   10  


<210>  42
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IEI peptide sequence

<400>  42

Ile Glu Ile Asn Ala Thr Arg Ala Gly Thr Asn Leu 
1               5                   10          


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IEI-L peptide sequence

<400>  43

Gly Gly Ile Glu Ile Asn Ala Thr Arg Ala Gly Thr Asn Leu Gly Gly 
1               5                   10                  15      


<210>  44
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV9 capsid

<400>  44

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  45
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAVhu68 capsid

<400>  45

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Val Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  46
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VLT-L peptide sequence

<400>  46

Gly Gly Val Leu Thr Asn Ile Ala Arg Gly Glu Tyr Met Arg Gly Gly 
1               5                   10                  15      


<210>  47
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-X-(T/I/V/A)-(K/R) motif


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is selected from Threonine (T), Isoleucine (I), Valine (V) or
       Alanine (A)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is selelcted from Lysine (K) or Arginine (R)

<400>  47

Asn Xaa Xaa Xaa 
1               


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV2 variant peptide NDVRAVS

<400>  48

Asn Asp Val Arg Ala Val Ser 
1               5           


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PHP.B peptide insert

<400>  49

Thr Leu Ala Val Pro Phe Lys 
1               5           


<210>  50
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence EFS

<400>  50
gagttcagca gcaacaccgt gaagctgacc agc                                    33


<210>  51
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence IEI

<400>  51
atcgagatca acgctaccag agctggaacc aacctg                                 36


<210>  52
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence IEI-L

<400>  52
ggaggaatcg agatcaacgc taccagagct ggaaccaacc tgggagga                    48


<210>  53
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence SAN

<400>  53
agcgctaact tcatcaagcc taccagctac                                        30


<210>  54
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence SSN

<400>  54
agcagcaaca ccgtgaagct gaccagcgga cac                                    33


<210>  55
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence SSN-L

<400>  55
ggaggaagca gcaacaccgt gaagctgacc agcggacacg gagga                       45


<210>  56
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence VLT-L

<400>  56
ggaggagtgc tgaccaacat cgctagagga gagtacatga gaggagga                    48


