                                         
 
<110>  ..,  ..,  ..
<120>   .  . .                                    
<160> 6

<210> SEQ ID NO: 1
<211> 482
<212> 
<213>  
<220> 
<221> 
<222>  1  69  
<223>  ,  91  160      
<220> 
<221> 
<222>  76  345  
<223>  S,  111  380    S  
<220> 
<221> 
<222>  352  411  
<223>  N,  301  360    N  
<220> 
<221> 
<222>  418  482  
<223>  E,  6  70    E   
<400> 1

Trp Leu Ser Tyr Phe Ile Ala Ser Phe Arg Leu Phe Ala Arg Thr Arg 
1               5                10                15      
Ser Met Trp Ser Phe Asn Pro Glu Thr Asn Ile Leu Leu Asn Val Pro
           20                25                30          
Leu His Gly Thr Ile Leu Thr Arg Pro Leu Leu Glu Ser Glu Leu Val 
        35                40                45              
Ile Gly Ala Val Ile Leu Arg Gly His Leu Arg Ile Ala Gly His His    
    50                55                60                  
Leu Gly Arg Cys Asp Gly Gly Gly Gly Gly Gly Asp Ser Lys Thr Gln
65                70                 75                80                         
Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys
               85                90                95      
Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys
           100               105               110         
Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala
       115               120                125             
Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu
    130               135               140                 
Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys 
145               150               155               160 
Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn   
              165                170               175     
Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
           180               185               190         
Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
       195               200                205             
Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr    
   210                215               220                 
Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
225               230               235               240 
Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys
              245                250               255     
Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
           260               265               270         
Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr
       275               280                285             
Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
    290               295               300                 
Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg
305               310               315               320 
Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser
              325                330               335     
Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Gly Gly Gly Gly Gly Trp
           340               345               350         
Pro Gln Ile Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met
       355               360                365             
Ser Arg Ile Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr 
    370               375               380                 
Thr Gly Ala Ile Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp Gln
385               390               395                400 
Val Ile Leu Leu Asn Lys His Ile Asp Ala Tyr Gly Gly Gly Gly Gly
              405                410               415     
Gly Ser Glu Glu Thr Gly Thr Leu Ile Val Asn Ser Val Leu Leu Phe
           420               425               430
Leu Ala Phe Val Val Phe Leu Leu Val Thr Leu Ala Ile Leu Thr Ala
        435               440               445
Leu Arg Leu Cys Ala Tyr Cys Cys Asn Ile Val Asn Val Ser Leu Val
   450                455               460
Lys Pro Ser Phe Tyr Val Tyr Ser Arg Val Lys Asn Leu Asn Ser Ser
465               470                475               480
Arg Val


<210> SEQ ID NO: 2
<211> 1446 
<212>  
<213>  
<220>	
<223> , .  ..  ,   
<400> 2

tggctgtcct acttcatcgc ctccttccgg ctgttcgccc ggacccggtc catgtggtcc        60
ttcaaccccg agaccaacat cctgctgaac gtgcccctgc acggcaccat cctgacccgg       120
cccctgctgg agtccgagct ggtgatcggc gccgtgatcc tgcggggcca cctgcggatc       180
gccggccacc acctgggccg gtgcgacggc ggcggcggcg gcggcgactc caagacccag       240
tccctgctga tcgtgaacaa cgccaccaac gtggtgatca aggtgtgcga gttccagttc       300
tgcaacgacc ccttcctggg cgtgtactac cacaagaaca acaagtcctg gatggagtcc       360
gagttccggg tgtactcctc cgccaacaac tgcaccttcg agtacgtgtc ccagcccttc       420
ctgatggacc tggagggcaa gcagggcaac ttcaagaacc tgcgggagtt cgtgttcaag       480
aacatcgacg gctacttcaa gatctactcc aagcacaccc ccatcaacct ggtgcgggac       540
ctgccccagg gcttctccgc cctggagccc ctggtggacc tgcccatcgg catcaacatc       600
acccggttcc agaccctgct ggccctgcac cggtcctacc tgacccccgg cgactcctcc       660
tccggctgga ccgccggcgc cgccgcctac tacgtgggct acctgcagcc ccggaccttc       720
ctgctgaagt acaacgagaa cggcaccatc accgacgccg tggactgcgc cctggacccc       780
ctgtccgaga ccaagtgcac cctgaagtcc ttcaccgtgg agaagggcat ctaccagacc       840
tccaacttcc gggtgcagcc caccgagtcc atcgtgcggt tccccaacat caccaacctg       900
tgccccttcg gcgaggtgtt caacgccacc cggttcgcct ccgtgtacgc ctggaaccgg       960
aagcggatct ccaactgcgt ggccgactac tccgtgctgt acaactccgc ctccttctcc      1020
accttcaagt gctacggcgg cggcggcggc ggctggcccc agatcgccca gttcgccccc      1080
tccgcctccg ccttcttcgg catgtcccgg atcggcatgg aggtgacccc ctccggcacc      1140
tggctgacct acaccggcgc catcaagctg gacgacaagg accccaactt caaggaccag      1200
gtgatcctgc tgaacaagca catcgacgcc tacggcggcg gcggcggcgg ctccgaggag      1260
accggcaccc tgatcgtgaa ctccgtgctg ctgttcctgg ccttcgtggt gttcctgctg      1320
gtgaccctgg ccatcctgac cgccctgcgg ctgtgcgcct actgctgcaa catcgtgaac      1380
gtgtccctgg tgaagccctc cttctacgtg tactcccggg tgaagaacct gaactcctcc      1440
cgggtg                                                                 1446


<210> SEQ ID NO: 3
<211> 1527 
<212>  
<213>  
<220>	
<223>    . -, . . ,  . . . , .   -.
<400> 3
 
gccgccacca tggggaagat ttctagtctg cctacccagc tgtttaagtg ttgcttttgt        60
gattttctga agttgatgtg gctcagctac ttcattgctt ctttcagact gtttgcgcgt       120
acgcgttcca tgtggtcatt caatccagaa actaacattc ttctcaacgt gccactccat       180
ggcactattc tgaccagacc gcttctagaa agtgaactcg taatcggagc tgtgatcctt       240
cgtggacatc ttcgtattgc tggacaccat ctaggacgct gtgacggagg aggaggagga       300
ggagattcga agacccagtc cctacttatt gttaataacg ctactaatgt tgttattaaa       360
gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca caaaaacaac       420
aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg cacttttgaa       480
tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt caaaaatctt       540
agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa gcacacgcct       600
attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt ggtagatttg       660
ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag aagttatttg       720
actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta tgtgggttat       780
cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac agatgctgta       840
gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt cactgtagaa       900
aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat tgttagattt       960
cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag atttgcatct      1020
gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc tgtcctatat      1080
aattccgcat cattttccac ttttaagtgt tatggaggag gaggaggagg atggccgcaa      1140
attgcacaat ttgcccccag cgcttcagcg ttcttcggaa tgtcgcgcat tggcatggaa      1200
gtcacacctt cgggaacgtg gttgacctac acaggtgcca tcaaattgga tgacaaagat      1260
ccaaatttca aagatcaagt cattttgctg aataagcata ttgacgcata cggaggagga      1320
ggaggaggat cggaagagac aggtacgtta atagttaata gcgtacttct ttttcttgct      1380
ttcgtggtat tcttgctagt tacactagcc atccttactg cgcttcgatt gtgtgcgtac      1440
tgctgcaata ttgttaacgt gagtcttgta aaaccttctt tttacgttta ctctcgtgtt      1500
aaaaatctga attcttctag agtttga                                          1527

<210> SEQ ID NO: 4
<211> 1535 
<212>  
<213>  
<220>	
<223> , . . , .  ..,  . . . , . , -.   .
<400> 4
 
ggatccgccg ccaccatggg gaagatttct agtctgccta cccagctgtt taagtgttgc        60
ttttgtgatt ttctgaagtg gctgtcctat ttcatcgcct ctttccggct gtttgcccgg       120
acaagatcca tgtggtcttt taacccagag acaaatatcc tgctgaacgt gccactgcac       180
ggaaccatcc tgacacggcc tctgctggag agcgagctgg tcatcggagc cgtgatcctg       240
aggggacacc tgagaatcgc aggacaccac ctgggcagat gcgacggagg aggaggagga       300
ggcgatagca agacacagtc cctgctgatc gtgaacaatg ccaccaacgt ggtcatcaag       360
gtgtgcgagt tccagttttg taacgaccca tttctgggcg tgtactatca caagaacaat       420
aagtcttgga tggagagcga gttcagagtg tacagctccg ccaacaattg tacatttgag       480
tacgtgagcc agcccttcct gatggacctg gagggcaagc agggcaactt taagaatctg       540
agggagttcg tgtttaagaa tatcgatggc tacttcaaga tctattctaa gcacaccccc       600
atcaacctgg tgcgcgacct gcctcagggc tttagcgccc tggagcccct ggtggatctg       660
cctatcggca tcaacatcac caggttccag acactgctgg ccctgcaccg ctcttacctg       720
acacctggcg actctagctc cggatggacc gcaggagcag cagcatacta tgtgggctac       780
ctgcagccaa ggacctttct gctgaagtat aacgagaatg gcaccatcac agacgcagtg       840
gattgcgcac tggaccccct gagcgagaca aagtgtacac tgaagtcctt caccgtggag       900
aagggcatct atcagacatc taattttcgg gtgcagccta ccgagagcat cgtgagattc       960
ccaaacatca caaatctgtg cccctttggc gaggtgttca acgccaccag gttcgccagc      1020
gtgtacgcct ggaataggaa gcgcatctcc aactgcgtgg ccgactactc tgtgctgtat      1080
aattctgcca gcttctccac ctttaagtgt tatggaggag gaggaggagg atggcctcag      1140
atcgcccagt ttgccccatc tgccagcgcc ttctttggca tgtcccgcat cggcatggag      1200
gtgaccccat ctggcacatg gctgacctac acaggcgcca tcaagctgga cgataaggac      1260
cccaatttca aggatcaggt catcctgctg aacaagcaca tcgatgcata cggcggcggc      1320
ggaggaggca gcgaggagac aggcacactg atcgtgaact ccgtgctgct gttcctggcc      1380
tttgtggtgt tcctgctggt gaccctggcc atcctgacag ccctgagact gtgcgcctac      1440
tgctgtaaca tcgtgaacgt gagcctggtg aaaccatctt tctatgtcta ctctcgggtc      1500
aaaaatctga actcatctcg ggtctgataa ctcga                                 1535


<210> SEQ ID NO: 5
<211> 1542
<212>  
<213>  
<220>	
<223>    . -, . . ,  . . . ,.   -.
<400> 5

gccgccacca tggccaccgg ctcccggacc tccctgctgc tggccttcgg cctgctgtgc        60
ctgccctggc tgcaggaggg ctccgccttg atgtggctca gctacttcat tgcttctttc       120
agactgtttg cgcgtacgcg ttccatgtgg tcattcaatc cagaaactaa cattcttctc       180
aacgtgccac tccatggcac tattctgacc agaccgcttc tagaaagtga actcgtaatc       240
ggagctgtga tccttcgtgg acatcttcgt attgctggac accatctagg acgctgtgac       300
ggaggaggag gaggaggaga ttcgaagacc cagtccctac ttattgttaa taacgctact       360
aatgttgtta ttaaagtctg tgaatttcaa ttttgtaatg atccattttt gggtgtttat       420
taccacaaaa acaacaaaag ttggatggaa agtgagttca gagtttattc tagtgcgaat       480
aattgcactt ttgaatatgt ctctcagcct tttcttatgg accttgaagg aaaacagggt       540
aatttcaaaa atcttaggga atttgtgttt aagaatattg atggttattt taaaatatat       600
tctaagcaca cgcctattaa tttagtgcgt gatctccctc agggtttttc ggctttagaa       660
ccattggtag atttgccaat aggtattaac atcactaggt ttcaaacttt acttgcttta       720
catagaagtt atttgactcc tggtgattct tcttcaggtt ggacagctgg tgctgcagct       780
tattatgtgg gttatcttca acctaggact tttctattaa aatataatga aaatggaacc       840
attacagatg ctgtagactg tgcacttgac cctctctcag aaacaaagtg tacgttgaaa       900
tccttcactg tagaaaaagg aatctatcaa acttctaact ttagagtcca accaacagaa       960
tctattgtta gatttcctaa tattacaaac ttgtgccctt ttggtgaagt ttttaacgcc      1020
accagatttg catctgttta tgcttggaac aggaagagaa tcagcaactg tgttgctgat      1080
tattctgtcc tatataattc cgcatcattt tccactttta agtgttatgg aggaggagga      1140
ggaggatggc cgcaaattgc acaatttgcc cccagcgctt cagcgttctt cggaatgtcg      1200
cgcattggca tggaagtcac accttcggga acgtggttga cctacacagg tgccatcaaa      1260
ttggatgaca aagatccaaa tttcaaagat caagtcattt tgctgaataa gcatattgac      1320
gcatacggag gaggaggagg aggatcggaa gagacaggta cgttaatagt taatagcgta      1380
cttctttttc ttgctttcgt ggtattcttg ctagttacac tagccatcct tactgcgctt      1440
cgattgtgtg cgtactgctg caatattgtt aacgtgagtc ttgtaaaacc ttctttttac      1500
gtttactctc gtgttaaaaa tctgaattct tctagagttt ga                         1542


<210> SEQ ID NO: 6
<211> 424
<212> 
<213>  
<220> 
<221> 
<222>  1  121  
<223>  ,  60  180      
<220> 
<221> 
<222>  128  202  
<223>  S,  306  380    S  
<220> 
<221> 
<222>  209  353  
<223>  N,  216  360    N  
<220> 
<221> 
<222>  360  424  
<223>  E,  6  70    E   
<400> 6

Val Thr Leu Ala Cys Phe Val Leu Ala Ala Val Tyr Arg Ile Asn Trp
1               5                   10                  15
Ile Thr Gly Gly Ile Ala Ile Ala Met Ala Cys Leu Val Gly Leu Met
            20                  25                  30
Trp Leu Ser Tyr Phe Ile Ala Ser Phe Arg Leu Phe Ala Arg Thr Arg        
        35                  40                  45
Ser Met Trp Ser Phe Asn Pro Glu Thr Asn Ile Leu Leu Asn Val Pro
    50                  55                  60
Leu His Gly Thr Ile Leu Thr Arg Pro Leu Leu Glu Ser Glu Leu Val
65                  70                  75                  80
Ile Gly Ala Val Ile Leu Arg Gly His Leu Arg Ile Ala Gly His His
                85                  90                  95
Leu Gly Arg Cys Asp Ile Lys Asp Leu Pro Lys Glu Ile Thr Val Ala             
           100                 105                 110
Thr Ser Arg Thr Leu Ser Tyr Tyr Lys Gly Gly Gly Gly Gly Gly Phe
        115                 120                 125
Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro
    130                 135                 140 
Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe
145                 150                 155                 160
Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn
                165                 170                 175 
Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn
            180                 185                 190
Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Gly Gly Gly Gly Gly
        195                 200                 205
Asp Ala Ala Leu Ala Leu Leu Leu Leu Asp Arg Leu Asn Gln Leu Glu
    210                 215                 220
Ser Lys Met Ser Gly Lys Gly Gln Gln Gln Gln Gly Gln Thr Val Thr
225                 230                 235                 240
Lys Lys Ser Ala Ala Glu Ala Ser Lys Lys Pro Arg Gln Lys Arg Thr
                245                 250                 255
Ala Thr Lys Ala Tyr Asn Val Thr Gln Ala Phe Gly Arg Arg Gly Pro
            260                 265                 270
Glu Gln Thr Gln Gly Asn Phe Gly Asp Gln Glu Leu Ile Arg Gln Gly        
        275                 280                  285        
Thr Asp Tyr Lys His Trp Pro Gln Ile Ala Gln Phe Ala Pro Ser Ala
    290                 295                 300     
Ser Ala Phe Phe Gly Met Ser Arg Ile Gly Met Glu Val Thr Pro Ser
305                 310                 315                 320
Gly Thr Trp Leu Thr Tyr Thr Gly Ala Ile Lys Leu Asp Asp Lys Asp                
                325                 330                 335
Pro Asn Phe Lys Asp Gln Val Ile Leu Leu Asn Lys His Ile Asp Ala
            340                 345                 350
Tyr Gly Gly Gly Gly Gly Gly Ser Glu Glu Thr Gly Thr Leu Ile Val        
        355                 360                 365
Asn Ser Val Leu Leu Phe Leu Ala Phe Val Val Phe Leu Leu Val Thr
    370                 375                 380                 
Leu Ala Ile Leu Thr Ala Leu Arg Leu Cys Ala Tyr Cys Cys Asn Ile
385                 390                 395                 400
Val Asn Val Ser Leu Val Lys Pro Ser Phe Tyr Val Tyr Ser Arg Val
                405                 410                 415
Lys Asn Leu Asn Ser Ser Arg Val
            420                                  


1


