                         SEQUENCE LISTING

<110>  OSPEDALE SAN RAFFAELE S.R.L.
       FONDAZIONE TELETHON
 
<120>  VECTOR

<130>  P121448PCT

<140>  PCT/EP2021/084276
<141>  2021-12-03

<150>  GB2019108.6
<151>  2020-12-03

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  1895
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary human MRC1 promoter

<400>  1
ccctgaatgt gattatatac ataattcaat taaatgtatt tgcttctgaa atatatataa       60

atgtaaatta ggcagtcact tttgtatatg atttatttat atttgaaagc cacaaatgac      120

ccatttaaac tattattttc ataagccagt gaaacaatgt ctgagaaaca tttttgtttt      180

gtctgttctg ttctataacc atcatttttt ttttcagtca tgtacagcct tagtgacaaa      240

gaaactttgg tcctctgtcc tacattttca ctatcttttt ccctccggtc aggataatct      300

caaatttaca tgttaaaaac aatcagtaag agaactacat cacatttcta ataggatgga      360

aacttttcaa ctttatcaca aagacaacga atgtggaggc tttccgtttg aagataaaac      420

tattcattta aaaaatttta aaaattacaa tgtttccagt agcttctttt tgaattacta      480

acatattcca cactctagta acggtttggc cagctaatcg ttagtttctg ctttaaaatg      540

ttctaaattc ctgttctact tttgaaaaat gacaacataa atgtttggag ggttattttc      600

tgcttaatga aagatctaga aacatatttt attctaagaa agaattccac ttgcctttaa      660

ataaagatat accttttgac caaacaatca gattttcttt ttcttttttt tcttttcttt      720

tttttttttg agatggagtt tcgcgtctgt cgcccaggct ggagtgtagt ggtgcgatcc      780

tgactcactg taacttccac ttcccaggtt caaacgattc tgttgcctca gcctcctgag      840

tagctgggct tacaggtgtg catgatcaca cccggctaac ttttgtattt ttagtagaga      900

cgggtttttg ccatgttgac caggctggtt tcaaactcct gacctcgggt gatctgactg      960

cctcggcctc ccaaactgct gggattgcag gcgtgagcca ttgtgcctgg ccagattttc     1020

tttttctagc aaggggaccc acttaaactt gaagaggacc gggatggttg aggctgggca     1080

gcaaggcttt actgcaaatc ctttaccact gttttttctg gctttctaga gaacgttcta     1140

gcaaaaggtt tctagaactt tctccttcct ggcctgactg acattccctc ttaggtgtag     1200

cctccttttc acttttcttc tgcctggagg aaatgaagct ccacggaact ttctgttgaa     1260

actttccaag aaaaaaaaga aaggctctaa gcactgaatg tggaaactga aggggatgag     1320

cttcaactct gaagtgtttc cagcgtaaaa ctgtcctttc cagggcccgt gtggctgtca     1380

cttcagagtg gaggttgtct gctgagggac ccctgactca gctgcttccc aggggaagct     1440

ccgtcttccg gcacaggtaa tggcctgcag cttgatctcc acccagcccc atctgagcag     1500

gccgggagct cccaggctgt ttcacttctc tccttcctga ctcctcacca tcaccatcgc     1560

cctctctcct ccccaccccg ccactcctct cccacacgtg tccctttctc cccttcctct     1620

gcgtctgctc ttctcagaag ttagcttacg aagcaaagtt gttactttga attcctgttt     1680

ttccagccac cctcatgtga caggatgtct cctcagtaga ggctttccct aaattcagga     1740

gccctttaaa agggagggct tcctctgtag ttcttttcag ctgggcagct ctgggaactt     1800

ggattaggtg gagaggcagt tggggggcct cgttgttttg cgtcttagtt ccgccctcct     1860

gtccatcagg agaaggaaag gataaaccct gggcc                                1895


<210>  2
<211>  1895
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary mouse MRC1 promoter

<400>  2
ctcgagccga gctctgaaat ggatgcttca aggatttgaa gagacaccag aagtgaaaaa       60

cgtgctattt tcccacagtt cctggcaata caaagattgt tttaaggcct atggaaattc      120

ctcttcctcc gttacctgaa attacagatt tgtgttgact tgctcacccc tcctaacctg      180

ataaaatctt ccaataagat aaaaatgatg gagacaaatc ctttgtggga tgttggactt      240

cactttatat cacatccagc gtctcgttac tgattctgat tttattcctg tgcatgtaag      300

acacgttgac ataataaaac catggatata cagatgcctg caattcagtt aactcttttt      360

tttcctcttc aaataagtca aagcaaaccc caattaggca aaacaatttg aatggcttgc      420

atttaaaaga ccaattaaaa cattttttgg tcagcaagca tgatgggaca cacttataat      480

cccagctctc agaaagtcaa aacagaggaa ccaagaattc aaggccagcc tgcgctacaa      540

acgcaagact gtttcggtgt tcctgtgata agtcagttac gcagtgattg aaaaggaaac      600

gtttgcagcc tctcaccagt tgtgggagaa ttttctttgt cagttaagcc ttgatagaat      660

gaaaaagaac ggtgggtccc ttctcagaat cttcctaatt taggcttttt aaaaagaaaa      720

ttcttgagag aaaccacagc ttattgggaa atgagtgtgt acctgcctca gcgtggatgg      780

gtctgaacag cttttcactt gaaggtaaac catctgttta caacttctaa gtcgccagtg      840

tttccagagc ttctttttga aacgatgaca tttcccacgc tccagtttca ggtcttccct      900

gactaaccac aaatatccat ttctaaatat tcttaattct tgttgaacgt ctggaaaaaa      960

aaaatcagtg tttaggtggg ttgtgtggtg ctttgtgaac gaccctgcaa aatcatgaag     1020

acgaaacccc actgtcatcg aatcaacaag caacttttgg actcaagcca ggctttcttt     1080

tgcaagagag agagagaggt cttccctttt tcaaactctg aggactgtaa tggttgaggc     1140

ctggcagcga accgacaaca aagctattgc cactatttcc tctggctttc taaggaaagc     1200

tgctagaact ttctatccct gggcttcatt gaggttgtct taaaattaac ttctgtcatt     1260

ttccttctag agacaggggc aaaactctac gtgaaccata cctttgatcc tttccaagga     1320

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt tggtgctcgg     1380

gctctaagcc tgagcaggaa gagcttctga tgctttccag cgagtgtcct ccctttctga     1440

ctgtagaatt gtgggtgaga gcctccacag ctgcctcctg gagacttttt cccacccaga     1500

taatggcctc cgtttggtta ctgcccagca cctgtggaga gctcagcagg gctgcctctc     1560

cctgctgctc atggcctggg tcctcacttc tccccacttc ctgcgttttc tcctctccta     1620

cacatgttcc tctctcccct tcctcctgtg ccttagctta cgaagcaaag ttgtaacttt     1680

gaattcctgt ttttctaacc gcccccatgt gacaggatat ctctcaattg gagggttttc     1740

ctaaattcag gagtccttta aaagggacag cttcctctgt cctccttttc agtcaggcag     1800

ctcccagacc ttggactgag caaaggggca acctggggac ctggttgtat tctttgcctt     1860

tcccagtctc cctcttctcc ctcattggaa ccggt                                1895


<210>  3
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary miRT-126

<400>  3
cgcattatta ctcacggtac ga                                                22


<210>  4
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary miRT-122

<400>  4
acaaacacca ttgtcacact cca                                               23


<210>  5
<211>  139
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary miRT-122 4 x miRT

<400>  5
tctagataaa caaacaccat tgtcacactc cattcgaaac aaacaccatt gtcacactcc       60

aacgcgtaca aacaccattg tcacactcca atgcatacaa acaccattgt cacactccac      120

ccgggtcgag ctcggtacc                                                   139


<210>  6
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary miRT-126 4 x miRT

<400>  6
ggtaccagca aacgcattat tactcacggt acgaccatcg cattattact cacggtacga       60

acttcgcatt attactcacg gtacgacgaa cgcattatta ctcacggtac gacacgtgtc      120

ggtacc                                                                 126


<210>  7
<211>  237
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary miRT-122 and miR126 4 x miRT

<400>  7
ggtaccagcg ctacaaacac cattgtcaca ctccaacata caaacaccat tgtcacactc       60

cagattacaa acaccattgt cacactccac agaacaaaca ccattgtcac actccagttt      120

aaacgcatta ttactcacgg tacgaccatc gcattattac tcacggtacg aacttcgcat      180

tattactcac ggtacgacga acgcattatt actcacggta cgacacgtgt cggtacc         237


<210>  8
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary human interferon-alpha

<400>  8

Met Ala Ser Pro Phe Ala Leu Leu Met Val Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser Leu 
            20                  25                  30          


Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile Ser 
        35                  40                  45              


Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg 
        115                 120                 125             


Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  9
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary human interferon-beta

<400>  9

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Ile Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210>  10
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary human interferon-gamma

<400>  10

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  11
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary human Interleukin-2

<400>  11

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  12
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary human Interleukin-12 subunit alpha

<400>  12

Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu 
1               5                   10                  15      


Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    210                 215                 


<210>  13
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary human Interleukin-12 subunit beta

<400>  13

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  14
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary human TNFa

<400>  14

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  15
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary human CXCL9

<400>  15

Met Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val 
1               5                   10                  15      


Leu Ile Gly Val Gln Gly Thr Pro Val Val Arg Lys Gly Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala 
65                  70                  75                  80  


Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 
            100                 105                 110         


Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 125 


<210>  16
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary human IL-1B

<400>  16

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  17
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Mrc1 enhancer 1

<400>  17
acagaaccag cagtataggg aaggccgtgg tgttgtggga ctcacatgat attatttatg       60

atatcttgga aattagagca aagacaggtt aggcattgtg gtcagaggag ctgggttatg      120

acaccgagga aacaagctga cccttgaatt aaaacatatt gacgccatag caataagagg      180

atggaaccac attgccctct gctgttgggg aatcatggcc gctgccccca ttctgcagtt      240

aagagacccg gtactgccct ctgctggctg gatgcacatg tttccacatt ctggattagt      300

atccttttga atttaaattt aaaaacagtc tcctgctgcc tgccagtgac tcactgtggc      360

ctctttatgt tgttagtagc tttgttttac tctggcagat agaaaatatg ttacaggtcg      420

ccatcttggt tccgggactc agca                                             444


<210>  18
<211>  503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human MRC1 enhancer 1

<400>  18
agccccacca tgttattgat ggccaaacaa tacgcatgct gacagccatt atctgtggcc       60

tctgatgcta ttagccaaac catgttattg atggtcaaac aatacgcatg ctgacagcca      120

ttatctggga ctcagaaagt tctgcatatt caagtcaggc cagaggatcc gagttctaat      180

gttaagagaa accaacacac caacaagcaa ataaacaaac ctacccttga accaaaatat      240

acatcaatac ctccgttgca aatggataaa tggaactgca ttgccctctg ctgttgggga      300

atcttggcaa ccatttcaac tctatggctg gagatgactt actgctctgt ttattttcca      360

tcctcctgct tagattattg ctttcaaagt ttccagaata gaagaagtca gtggtggcca      420

gttgtccttt aatggtctct tatctaccaa tggctagtat cctttttgca ttatcgtagc      480

tctactcttg tagatgttaa att                                              503


<210>  19
<211>  748
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Mrc1 enhancer 2

<400>  19
acatgggagg caaggcggaa ggagcatgag gctgacctag caggcaggaa gcacagaaat       60

cacattttga gctacataga agaaggagag agagagagag agagagagag agagagagag      120

agagagagag agagagagag agagagagag agagaaatca ggaagtgaga ctagtctata      180

aaactgcaaa gcctactccc actgacatac ttcctttagc aatgcacagc tgccacaacc      240

ctcccaaatc ctgccaccaa ctggagacca agggttacaa taagtagacc taagggaggg      300

gtacttttct tttcaaccac tgcagtggag cacacctcta tgtccaacat gaaggaaata      360

gaggctggaa gaccagaaat tcaaggtcac ccaccagctc atcgccagtt gcagatcagt      420

ttgagctaca ggctatctgc ctcaaatata aaactaaaca gaaagtcaat aaaaaggcca      480

cacttgggga agtggataat agggtcaaat attagtaaac acctcttctt ccccattgtt      540

aaagcctgct ccctccagtt cctctgactt tactgttaca taacagatct tggacctgtg      600

actgctgtgt ttacaacata ctcagtgacc cctaacttct aatcatgaaa cacatttacc      660

cggttccagg atgccatctc tccacctaca gctcaccatg gaagcatttt gcctcttagc      720

aaaggtcttt ggtttctcgt gggtggca                                         748


<210>  20
<211>  1301
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human MRC1 enhancer 2

<400>  20
tttattagat tgtgaagact aaaagggcta aagtttgctt gagaagagag tatccgtttt       60

agcttctaaa atatacactt ggggaaacag agagattagg atcagaaatt agtgtgggag      120

caaaagcatc cccgatttct tgcccccaaa atctcctccc tccagttttt ctggacacgg      180

ctatattaat attagtctgt ctctgctcct atgactgcca tgttcaaaaa accccttgtg      240

gcttctcatt tcccatcaaa taattaacaa aatacatttt gcctgacatt caagattgcc      300

acctgctgaa catctgtact attcccggtc ttgcattttg cggtcacaac aaaagaaaag      360

tcagtcttgg attccttgtt tttcctcatc cattctcacc ctcacatctt ttcccatgtc      420

atttcttttg cctggaattc tcacgattgt gtacagttga aatgcaattc tatttccatc      480

tgcatttctc ttatttgctt attaccactt ttattagtat aatagctact tacacatatg      540

tcctgcttcc ttgacaacac tataaataca ttaatttgtt attatttatt tacttattca      600

ttcattccca agatatcttg tacccatgtg ccaggctttg tgctaggtcc tggggacatc      660

aaagctgacc ctgtcttgtc cacatgcagc ttaaaagtcc aatgggaaga aacagatgta      720

aacaagaaaa caaacaaatg aataggtacc aattataata agtcctgcat ggaaagcaaa      780

ctgaaggcca tgtggagatc gcgtcagagg gggaaatagc tgaaaacggg gaatgtcttg      840

tgaatattta tgacccctct tcccccaagg aggttcacac agagccttcc aaggaagggt      900

ctcaccaaac atttgctgac tgacatgtta acatgcaaca aaataaaaat acttagaaat      960

tcagtctcct gtttggaaaa ctagacagtc atggcaagaa gacagtaaat gcagtggttc     1020

ttctgtgtga agtggcttat tcatcacctt ggaattctgt taaagtgatg atgcctgggc     1080

tgagatcccg aagactctag atcagtaggt gtgacacagg gcacaagaat ctgccttttg     1140

tcaaactcct gggtgattct ggggcagctg gttgaaagac catatctggc aaaacactgt     1200

gttagttcct gctgtatcca ggtgctaaca ccaggcagca gagcagagag gctgagagca     1260

aagattctgc agccagactg cctaggtccc agctctgtga a                         1301


<210>  21
<211>  1044
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Mrc1 enhancer 3

<400>  21
ggtcaactat atagtaatga acacctatca attattttcc ttaatatatt agattttatt       60

cctcttaatt cagcatcact tgcattctaa tgaagatctc tatgtccttc cagccatgta      120

ctccttactg ggcaatgcaa atggagccgt ctgtgcattt ccattcaagt ttgaaaacaa      180

gtggtatgca gactgcacct ctgccgggcg ctcggacgga tggctctggt gtggaaccac      240

cactgactac gacaaagaca agctgtttgg attttgtcca ttgcactgta agtaactgaa      300

aacagcacac ctgggacatt cagtatggtc acatgatggt agggtggact ttatgtaccc      360

tctatctacc tttctttgtt tcttgtttca ctttcacttc tctctctctc tctctttcct      420

tccccatctt tctgtttgct aaggatcaaa cccagccttg cacatgctaa acaaacactc      480

tactactgag ctacatatcc tgaccttatt agttatttgc taagacttta gggcaaatta      540

tactgaatat agcattatat atagtcagtg ctggaggtag gtacatcgtt ctcccaaacc      600

ccaagtgttt tagttttaaa aagccatagg ttaaagcagg aatttaaata acaccacaaa      660

cgagtttggt gggagtctgt gaaggctctt gcattttgca tcaccatgtg ctggagctcc      720

ttctagtaca gatgatactg atggaggttt gtgaatctca acgtaagaag ggtggaattc      780

agctgagttg gcaatcaagg gaagtgagta atctatgctt cagtcctttg aaagcagaag      840

tttggtgtta ctagagcatg caagaccaca taaagtacca gaacttgaat tcttgaggtt      900

ttatccattc gtaagaatct gtaagaaaat atgtggcagc ttaggtgggg ctagggaggg      960

cagctgggag tcagagctag ggctgaggga ggagaaggtt gaggtcttgg cttaacttct     1020

gtatctctga acatactttc tgaa                                            1044


<210>  22
<211>  2077
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human MRC1 enhancer 3

<400>  22
cagcctcccg agtagctggg actacaggcg cccgccacca cgcctggcta attttttgta       60

tttttagtag agacggggtt tcactgtgtt agccaggatg gtctcgatct gctaacctcg      120

tgatccgccc acctcgcctc ccaaagtgtt gggtttacag gcatgagccg gcgcgcccga      180

ctatgacctc tttattttta ccaactatca gttactcagc gaaaattatc ctgtacacaa      240

tatagtatat acttaacacg ggaggtaggt aggcatgcta ttattccctc atctctgaaa      300

tgccttacct ttatgaaacc atagatcaaa aacagaattc aaaggaagcc acaagcatgt      360

ggtttgatgg agaaagacgt gaaggtcctg aattttgtgt caatgtcatc aaaagtgttc      420

ttcacagtga aaatgatagt caggatactc ttcttatgtt taaattaaga agggtgccat      480

ttagtttcac acagctagaa atcaatggaa ctcggtaatt tatatgcttc aaggtttctt      540

aaaaatgaaa attcaggttt tattgcaagg atgcaaaata agcagtatcg cattatctta      600

gtgggaaagc accagaacag atgaattctt ggtgttcttc cacgcttaaa aatctgtagg      660

caaatagtga agcacatttt aggtggagtg gaggagggcg tcatgttgaa ggcagagctg      720

gggctgagga aaaaggaaaa ggaagtattc ctcttagctt cacgttcccc atcaccagac      780

accctcctcc tgatgctggc tccacccttc ccaaacttct tacccccgac ctctcacctg      840

ctactttaga ccagatcaga gtagctcttg tttcctggtt atcacccaga actctttctc      900

ctgctgccct gcaaagggac tgggcagagc aaagagcatt cgatatggtc tgggatgatt      960

gtgacaccac ctgagtaaca atagaatcac gactatcaca actcaacttt ccagaccaca     1020

aatccacaag taatcacact atttcaagca ttattgtaaa acagaacaac ttaaaaaata     1080

cctgaatttg acgaacaaaa gccagaattc taagaattgt acttatttat ctctctggat     1140

ttataatccc taattatcac actaaaagta aatttaattt ctgagcccca tatactattg     1200

taattgtctt cagagtgcag tctctccaat ccgaatgaat actcacaaaa gcccataggc     1260

tttctgttca tagcgacact gctgcctcgg tcttaactga ggtagttcta tttgtctctc     1320

ttatgtcaat ctttagaaag acatttgatt tccattcaag gtttttagat gtcgaatttt     1380

gtattcgaag tatttttgtc tgaaacacat tgagcaattt ttttctaaga taaagcaata     1440

cttggttttc aagtgattga aagtgtcttt ctcctttact taataggaat gatattttct     1500

taatctgttt catggacttt cttaagggta tatatttcat gggtccaact atagcatcct     1560

ccacatcctt tgaaattgac aaaggagtta gatgaatgtg tgatttcctg aatgaaatgt     1620

ggaggacaag tggtaagtta ctaatcacaa agaaaactca caatcttgga aatccttgga     1680

tgtgtgttgg agacgtatct tgagtttgtt cagtggaata attttttagt cttattactt     1740

gtatttatgc cttcactgtc aaattatata ttttttcctg ttaaatgtaa aataatcgta     1800

gaaaataaat tgatttggtt tcaatatgca ttaaaatttt aaatcacgtt ttgtacattt     1860

aatatctttc ttaaagggct ttatagtctt ccagtctgtt tcattttgtg ttcttttcaa     1920

aagagttttt attgtattta tttatttatt tatttttgag acagggtctc actctgtcat     1980

ccagactgga gtgcattagc atgatcttgg ctcaccacaa cctctgcctc ccaggctcaa     2040

gtgattctcc tgcctcagcc tcctgagtag ctgggat                              2077


<210>  23
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Mrc1 enhancer 4

<400>  23
aataaacgtc taggaacatt taccctaaag tactgccctc tctatgtgaa caaacttaag       60

cctgtgttct ttcctttttg tgaacagacg cgaggcaatt tttaatctat aatgaagatc      120

acaagcgctg cgtggacgct ctaagtgcca tctcagttca gacggcaact tgcaacccgg      180

aagctgaatc ccagaaattc cgctgggtgt cagattctca gatcatgagt gttgctttca      240

aattatgttt gggagtgcca tcaaaaactg actgggcttc cgtcaccctg tatgcctgtg      300

attcgaaaag tgaatatcag a                                                321


<210>  24
<211>  311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human MRC1 enhancer 4

<400>  24
tggaagagtt ggaaactttt gacctaaaag atcgtccttg ttacatgaat ccacttagcc       60

atgcttgctt tcttcttctt ttcctgcttc tttcttttta aacagacacc aggcaatttt      120

taatctataa tgaagatcac aagcgctgcg tggatgcagt gagtcccagt gccgtccaaa      180

ccgcagcttg caaccaggat gccgaatcac agaaattccg atgggtgtcc gaatctcaga      240

ttatgagtgt tgcatttaaa ttatgcctgg gagtgccatc aaaaacggac tgggttgcta      300

tcactctcta t                                                           311


<210>  25
<211>  426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Mrc1 enhancer 5

<400>  25
tgtcaggttc tctggagcac cctctcacct gttcagacta atttcctaag ttcggcgggt       60

cccggaccaa gatggcgacc cgctacattt cattcttaca tgcaggggat gagcgcactg      120

tttcaccact ttgattgcct tttttgagca tggtagatat tcagtaagca acccatggat      180

tgaattctac tttatgttta atgcaggacg aaaggcggga tgtgttgcca tgaaaaccgg      240

agtggcaggt ggcttatggg atgttttgag ttgtgaagaa aaggcaaaat ttgtgtgcaa      300

acattgggca gaaggagtga ctcgcccacc agagcccaca acaactcctg aacccaaatg      360

tccagaaaac tggggtacca ccagtaaaac cagcatgtgt ttcaaagtaa ggatcactcg      420

ccaaat                                                                 426


<210>  26
<211>  658
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human MRC1 enhancer 5

<400>  26
catcctcatt ttattttatg tacttctttg ttcgttaaag ctggcattcc ttacagttct       60

atgaggcagg tcttggtatt tgcatttgga gaggagaaag caagttcaga gcgtttgagt      120

aacttaccta aaatctctag ttgagacgtg tctcattttg aaatctgtga aaaactttgg      180

tcctggaaaa cctacgtaga ccttagtggg aggaaaagaa tcttaaaaaa ttaaaaaaga      240

aagaaagcag agaaaaccag aaaggggagg aagggaagaa ggaaggaaaa agggaaggaa      300

ggagggaggg agagagaagc agtaaactat ttttgccatt atggtgaatt tgataatata      360

aaatatttta tcattaaatg cctgtgtagg gggcactttg ccaaatgtta gaaatataaa      420

gtgttacaaa cccccctgca tctgagatca taattgggca tcagaaccct gatgctcggt      480

tctgagtgcc ttctgtgagc acggcaggcc ttcagcaggc acctgtcaag tgaattctac      540

ttcatatatt taatgcaggg cgaaagccag ggtgtgttgc catgagaacc gggattgcag      600

ggggcttatg ggatgttttg aaatgtgatg aaaaggcaaa atttgtgtgc aagcactg        658


<210>  27
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Mrc1 enhancer 6

<400>  27
gagtgattgt gcatgaactt gtggagacct caattgttct tgcaacttgt ctcttctatt       60

actattgcaa aaggaatggc taagtctttc ttgaaagaat tcatatagtt ctctttcaga      120

gacctgcagc agttaccact ttggggaact agagaaaagt tatttttaag tttctctgga      180

atgaaaggca caattctata atttggcctt attgcttaat ccaccagttt taagttcctt      240

gtttgtaaaa tatgaatgtt agtaactctt cttctttaaa atctcgttat atcatcaagc      300

ttg                                                                    303


<210>  28
<211>  1001
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human MRC1 enhancer 6

<400>  28
tttggccaag atcctaaata gatatagatg cgggacctgg atgttgggtt tgattatcct       60

ttacaggctc tccatagtga cggtgggtat ctttagagaa agctcaccat ttttgcattt      120

tacctctact attcctcctc taggagaaat agtgtatttt ttcctttttt ggaagccttc      180

attacaattc tctttctaag acttggaatt tccatgttgc caaagaggag aatagttact      240

ttatagtttc tctggtacag cactcagaat tctgtaactt ggccttactg cttaacctgc      300

cggtgctggg atcctcatgt gtaaaatgga aatgttcatg actcttcttc ctgagataaa      360

attttgttca tttcatcaaa cactcagtac attcttattc ctccatgatg ccttcttcac      420

tcgctaacca cttgatgtca gtttctgaac atctctatac tccctggatt aatgattctg      480

ttttatctat aaactcaaat aaaccagagc ttggaaaagc gtatcagagt tcaaattatg      540

cagcatacgg gattagcaac agccttaggc aagaattcaa cctcaaaccc tgtgaattat      600

tgtaacacta acccgtttgt ccataatcct caggtctcta gggctgtact ctctggctta      660

gcagccactt aaccgcatgt ggccactgag cacatgagct gtggctagag gaacaaatca      720

tcttctgtgg ctgccccagg gaactcccct tcatttcact caagttggtt gttttcatgc      780

tttcaaatat gtttaaagtt catcatttca gtttttgaag gacagcattg gctgatacta      840

ttttcaattt cctaggtagc aaaattaaaa taacccacca gagggctcca aagctgtact      900

aagcttgctt tctttttctt tttcttcttt ttttttttgt aaccactgga agtgcacaga      960

atctaaattg tattgaggga atagaatttt tttaaatatg c                         1001


<210>  29
<211>  1312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Mrc1 enhancer 7

<400>  29
atgagacgtc tgtcctggtt tgaactttgc caactgagcc ttattgccag cctgactgtt       60

actaggaatg ggtcatgaaa taaatgcttc tgtcagaata gtttattcgg attgaatgtg      120

ctctgcaacc tctgctgaca gccatcttcc cgagtgtgtg cagcaaccag cccgaatgtg      180

tcagcaatgg ctttcaggca cctgtgacac acgtatcaca agtaggatgt tttgatgttt      240

gcagggttat agcttcttca ggcaaaactt gcagggcatg aagaaagcag attcagcaag      300

gaccttagcc tgagcagctg actcgaatcg actgccaagt agcaaggaat ctggcacgcg      360

ttctgagctc cttggccagc ctgaaccggc tgaagctcaa gcctcaagct cgcctctgca      420

cccccgcacc tccccccgcc ccccaccagt gcagacagtt ttcctgcttt ttgttgttgt      480

tcctttcttg ttttatttaa aagccagatt cctttcatga agggcagcaa acatgtgagc      540

tctgcacatg cgcagcagtg aagaaattag ctgaggaagt tgaggctgtg tcagggcacc      600

tttcctgaag tggatccttg gacatccaag ccactgtgtt cttttggcct gtcttcaacg      660

gagtacgttg tatggtgcca agcctcagga taccaaagaa ctgcttacaa aacacttgct      720

ccttcacaag aagcacagca gtttagccaa gataacatcg ctgccaagaa ctctcacata      780

ggctaagata aaaactgaaa gccccagcac atgagagtga gttcttggta ggaaaaagca      840

cagtaagttc ttctcagccc tcaccgtcaa gatggctggc acgtgccacc tactcagcag      900

agatctggat gtctcaacag tatagttcac ctttctgtgt ggatgggcat ctccctgtcc      960

actgagggcc taggaagaac aaaagcagca gcaggaggag tccactcttt tgcttctagt     1020

cttcctgttt aagccgggag cttcccacct cactgtcctt ggaataggtt tcacgccact     1080

ggctggcttc cctgctttgt gtgtcttaga acttagattg aattctacca cctgctcctc     1140

tgggtcttca acttgcaggg aggtcttgga attatcagcc ttcacaattt ggccagcctg     1200

aaccgctcaa gctcaagcct caagctcgcc tctgcaaccc cgcacctccc cccccccgcc     1260

ccagtgcaga cagttttcct gtttttgttg ttgttccttt ctgaattaat tt             1312


<210>  30
<211>  1387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human MRC1 enhancer 7

<400>  30
gaagaaaaca catccagttc ttggaggaaa attgcaataa atattttgaa gagagttcca       60

tctcttattc tccctcaatt ttctgaaagt cagagtaaca cttggctata aaagtgatag      120

ggaaactaag tgcctatcat ataccaggca cagtggcatg caatcaagtg ggatttcatg      180

tatttcccaa gtgtgttttg ctggctgcca tgtaagaccc tagtgttaat tccaaaactc      240

agaggtcctg gctcttgaat gggtggggac aggaggtgga tttaaagttt ccagcagaga      300

agaagtgtgg gactgatcgt ctgctggaac cagttctctg aatatgatgg tttatctggc      360

aaggtttgat tccctcaagg aagttccagg ctaaaagagg agctaagctt ctacagtctc      420

tgagcttttt gtgttactga tcttgagtct tattaaaaaa aaaaaaaaaa aaaaaaaaac      480

cctgacttta tctggccgtg ccaggctccc ttctgggccc ttgctgccgt gtgtcagtac      540

gctgtaacta gagatggatt atgtaagaaa tgtttttgtc agaagaggct gttgcagtat      600

tttatgtgcc ctggtgcaca gcacctctgc tgtgagtccc ctccccgtgt gagttgcagc      660

ctcgctggat acacctgcta ctggtctcaa gcacctgtga tttattggtc atgaagcagg      720

tactgggact cctgctttta ttatctgcac ggccatccct cagccagtat agatgcccag      780

gctagacttg cagagcatga agaaggaagc agaaccagtt tgggaccttc gcctgagcag      840

ctgactcaac tccactgcca agcagccagg aatctggcac agtttctgag atgtctcagc      900

caactggtat ttctgaagcc atagttttcc tctgagctcc ccctcaacat gggtatagtc      960

attgtgcttg ttttgcttct tccttgttct tgtttaaaag ccagttttct tccttgaaag     1020

gcagtgaaat ctctgggttt tccatgtggg tagagaggag caggcggaac aagcttaggg     1080

aggccaggcg gtaacaggta accatttctt gaagttgatc ctcagagcat ccaagccagt     1140

gggttcattt ggatgatctt cagccaggca tagtccctgg tgccaagcct caggatatca     1200

aagaactact tacaaaatat gtgttccttc ataaggaaaa gaatggttta gctcagaggg     1260

cgtgcctgcc aataaatctc acataggtta agacacaaac tgaaaaaatg ctcaaggacc     1320

atgagccaca gtcactggag aagccacagt cattcattct ccagcagttc cccttaacca     1380

cctacca                                                               1387


<210>  31
<211>  1896
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary XhoI-Human.MRC1.promoter

<400>  31
ctcgagccct gaatgtgatt atatacataa ttcaattaaa tgtatttgct tctgaaatat       60

atataaatgt aaattaggca gtcacttttg tatatgattt atttatattt gaaagccaca      120

aatgacccat ttaaactatt attttcataa gccagtgaaa caatgtctga gaaacatttt      180

tgttttgtct gttctgttct ataaccatca tttttttttt cagtcatgta cagccttagt      240

gacaaagaaa ctttggtcct ctgtcctaca ttttcactat ctttttccct ccggtcagga      300

taatctcaaa tttacatgtt aaaaacaatc agtaagagaa ctacatcaca tttctaatag      360

gatggaaact tttcaacttt atcacaaaga caacgaatgt ggaggctttc cgtttgaaga      420

taaaactatt catttaaaaa attttaaaaa ttacaatgtt tccagtagct tctttttgaa      480

ttactaacat attccacact ctagtaacgg tttggccagc taatcgttag tttctgcttt      540

aaaatgttct aaattcctgt tctacttttg aaaaatgaca acataaatgt ttggagggtt      600

attttctgct taatgaaaga tctagaaaca tattttattc taagaaagaa ttccacttgc      660

ctttaaataa agatatacct tttgaccaaa caatcagatt ttctttttct tttttttctt      720

ttcttttttt tttttgagat ggagtttcgc gtctgtcgcc caggctggag tgtagtggtg      780

cgatcctgac tcactgtaac ttccacttcc caggttcaaa cgattctgtt gcctcagcct      840

cctgagtagc tgggcttaca ggtgtgcatg atcacacccg gctaactttt gtatttttag      900

tagagacggg tttttgccat gttgaccagg ctggtttcaa actcctgacc tcgggtgatc      960

tgactgcctc ggcctcccaa actgctggga ttgcaggcgt gagccattgt gcctggccag     1020

attttctttt tctagcaagg ggacccactt aaacttgaag aggaccggga tggttgaggc     1080

tgggcagcaa ggctttactg caaatccttt accactgttt tttctggctt tctagagaac     1140

gttctagcaa aaggtttcta gaactttctc cttcctggcc tgactgacat tccctcttag     1200

gtgtagcctc cttttcactt ttcttctgcc tggaggaaat gaagctccac ggaactttct     1260

gttgaaactt tccaagaaaa aaaagaaagg ctctaagcac tgaatgtgga aactgaaggg     1320

gatgagcttc aactctgaag tgtttccagc gtaaaactgt cctttccagg gcccgtgtgg     1380

ctgtcacttc agagtggagg ttgtctgctg agggacccct gactcagctg cttcccaggg     1440

gaagctccgt cttccggcac aggtaatggc ctgcagcttg atctccaccc agccccatct     1500

gagcaggccg ggagctccca ggctgtttca cttctctcct tcctgactcc tcaccatcac     1560

catcgccctc tctcctcccc accccgccac tcctctccca cacgtgtccc tttctcccct     1620

tcctctgcgt ctgctcttct cagaagttag cttacgaagc aaagttgtta ctttgaattc     1680

ctgtttttcc agccaccctc atgtgacagg atgtctcctc agtagaggct ttccctaaat     1740

tcaggagccc tttaaaaggg agggcttcct ctgtagttct tttcagctgg gcagctctgg     1800

gaacttggat taggtggaga ggcagttggg gggcctcgtt gttttgcgtc ttagttccgc     1860

cctcctgtcc atcaggagaa ggaaaggata aaccct                               1896


<210>  32
<211>  509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary XhoI-Human.MRC1.enhancer

<400>  32
ctcgagagcc ccaccatgtt attgatggcc aaacaatacg catgctgaca gccattatct       60

gtggcctctg atgctattag ccaaaccatg ttattgatgg tcaaacaata cgcatgctga      120

cagccattat ctgggactca gaaagttctg catattcaag tcaggccaga ggatccgagt      180

tctaatgtta agagaaacca acacaccaac aagcaaataa acaaacctac ccttgaacca      240

aaatatacat caatacctcc gttgcaaatg gataaatgga actgcattgc cctctgctgt      300

tggggaatct tggcaaccat ttcaactcta tggctggaga tgacttactg ctctgtttat      360

tttccatcct cctgcttaga ttattgcttt caaagtttcc agaatagaag aagtcagtgg      420

tggccagttg tcctttaatg gtctcttatc taccaatggc tagtatcctt tttgcattat      480

cgtagctcta ctcttgtaga tgttaaatt                                        509


<210>  33
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary BamHI-KOZAC

<400>  33
ggatccgcca cc                                                           12


<210>  34
<211>  570
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary Human.IFNA

<400>  34
atggcctcgc cctttgcttt actgatggtc ctggtggtgc tcagctgcaa gtcaagctgc       60

tctctgggct gtgatctccc tgagacccac agcctggata acaggaggac cttgatgctc      120

ctggcacaaa tgagcagaat ctctccttcc tcctgtctga tggacagaca tgactttgga      180

tttccccagg aggagtttga tggcaaccag ttccagaagg ctccagccat ctctgtcctc      240

catgagctga tccagcagat cttcaacctc tttaccacaa aagattcatc tgctgcttgg      300

gatgaggacc tcctagacaa attctgcacc gaactctacc agcagctgaa tgacttggaa      360

gcctgtgtga tgcaggagga gagggtggga gaaactcccc tgatgaatgc ggactccatc      420

ttggctgtga agaaatactt ccgaagaatc actctctatc tgacagagaa gaaatacagc      480

ccttgtgcct gggaggttgt cagagcagaa atcatgagat ccctctcttt atcaacaaac      540

ttgcaagaaa gattaaggag gaaggaataa                                       570


<210>  35
<211>  630
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary SalI-WPRE

<400>  35
gtcgacccga cagtttcgac aatcaacctc tggattacaa aatttgtgaa agattgactg       60

gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt      120

atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc      180

tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt      240

ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga      300

ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct      360

gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat      420

cgtcctttcc ttggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct      480

gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc      540

tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg      600

cctccccgcc tggaattcga gctcggtacc                                       630


<210>  36
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary AfeI-4xmiRT122-4xmiRT126-PmlI

<400>  36
agcgctacaa acaccattgt cacactccaa catacaaaca ccattgtcac actccagatt       60

acaaacacca ttgtcacact ccacagaaca aacaccattg tcacactcca gtttaaacgc      120

attattactc acggtacgac catcgcatta ttactcacgg tacgaacttc gcattattac      180

tcacggtacg acgaacgcat tattactcac ggtacgacac gtgtc                      225


<210>  37
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary single chain human Interleukin-12

<400>  37

Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala Ile Ala Gly Gln Leu Met Trp Glu Leu Lys 
            20                  25                  30          


Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly 
        35                  40                  45              


Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr 
    50                  55                  60                  


Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu 
65                  70                  75                  80  


Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His 
                85                  90                  95      


Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys 
            100                 105                 110         


Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro 
        115                 120                 125             


Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg 
    130                 135                 140                 


Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser 
145                 150                 155                 160 


Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly 
                165                 170                 175     


Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr 
            180                 185                 190         


Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu 
        195                 200                 205             


Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys 
    210                 215                 220                 


Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro 
225                 230                 235                 240 


Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln 
                245                 250                 255     


Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser 
            260                 265                 270         


Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg 
        275                 280                 285             


Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile 
    290                 295                 300                 


Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr 
305                 310                 315                 320 


Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Arg Ala Gly 
                325                 330                 335     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Thr 
            340                 345                 350         


Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
        355                 360                 365             


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
    370                 375                 380                 


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
385                 390                 395                 400 


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
                405                 410                 415     


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
            420                 425                 430         


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
        435                 440                 445             


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
    450                 455                 460                 


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
465                 470                 475                 480 


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
                485                 490                 495     


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
            500                 505                 510         


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
        515                 520                 525             


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
    530                 535                 540                 


Tyr Leu Asn Ala Ser 
545                 


<210>  38
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary human Interleukin-10

<400>  38

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  39
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL10

<400>  39
atgccaggct ccgccctgct gtgctgtctg ctgctgctga ccggcatgag gatcagcaga       60

ggacagtact cccgggagga caacaattgc acccacttcc ctgtgggaca gtcccacatg      120

ctgctggagc tgcgcacagc tttttctcag gtgaagacct tctttcagac aaaggaccag      180

ctggataaca tcctgctgac cgacagcctg atgcaggatt tcaagggcta cctgggatgt      240

caggccctgt ccgagatgat ccagttttat ctggtggagg tgatgcctca ggctgagaag      300

cacggccccg agatcaagga gcacctgaat tctctgggag agaagctgaa gacactgcgg      360

atgcgcctga ggagatgcca caggttcctg ccttgtgaga acaagtctaa ggccgtggag      420

caggtgaaga gcgactttaa taagctgcag gatcagggcg tgtacaaggc catgaacgag      480

ttcgatatct ttatcaattg catcgaggct tatatgatga tcaagatgaa gagctga         537


<210>  40
<211>  1674
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL12

<400>  40
atgtgtcctc agaagctaac catctcctgg tttgccatcg ttttgctggt gtctccactc       60

atggccatcg ccgggcaatt gatgtgggag ctggagaaag acgtttatgt tgtagaggtg      120

gactggactc ccgatgcccc tggagaaaca gtgaacctca cctgtgacac gcctgaagaa      180

gatgacatca cctggacctc agaccagaga catggagtca taggctctgg aaagaccctg      240

accatcactg tcaaagagtt tctagatgct ggccagtaca cctgccacaa aggaggcgag      300

actctgagcc actcacatct gctgctccac aagaaggaaa atggaatttg gtccactgaa      360

attttaaaaa atttcaaaaa caagactttc ctgaagtgtg aagcaccaaa ttactccgga      420

cggttcacgt gctcatggct ggtgcaaaga aacatggact tgaagttcaa catcaagagc      480

agtagcagtt cccctgactc tcgggcagtg acatgtggaa tggcgtctct gtctgcagag      540

aaggtcacac tggaccaaag ggactatgag aagtattcag tgtcctgcca ggaggatgtc      600

acctgcccaa ctgccgagga gaccctgccc attgaactgg cgttggaagc acggcagcag      660

aataaatatg agaactacag caccagcttc ttcatcaggg acatcatcaa accagacccg      720

cccaagaact tgcagatgaa gcctttgaag aactcacagg tggaggtcag ctgggagtac      780

cctgactcct ggagcactcc ccattcctac ttctccctca agttctttgt tcgaatccag      840

cgcaagaaag aaaagatgaa ggagacagag gaggggtgta accagaaagg tgcgttcctc      900

gtagagaaga catctaccga agtccaatgc aaaggcggga atgtctgcgt gcaagctcag      960

gatcgctatt acaattcctc atgcagcaag tgggcatgtg ttccctgcag ggtccgatcc     1020

cggcgcgccg gcggcggcgg cagcggcggc ggcggcagcg gcggcggcgg cagccgtacg     1080

agggtcattc cagtctctgg acctgccagg tgtcttagcc agtcccgaaa cctgctgaag     1140

accacagatg acatggtgaa gacggccaga gaaaaactga aacattattc ctgcactgct     1200

gaagacatcg accatgaaga catcacacgg gaccaaacca gcacattgaa gacctgttta     1260

ccactggaac tacacaagaa cgagagttgc ctggctacta gagagacttc ttccacaaca     1320

agagggagct gcctgccccc acagaagacg tctttgatga tgaccctgtg ccttggtagc     1380

atctatgagg acttgaagat gtaccagaca gagttccagg ccatcaacgc agcacttcag     1440

aatcacaacc atcagcagat cattctagac aagggcatgc tggtggccat cgacgagctg     1500

atgcagtctc tgaatcataa tggcgagact ctgcgccaga aacctcctgt gggagaagca     1560

gacccttaca gagtgaaaat gaagctctgc atcctgcttc acgccttcag cacccgcgtc     1620

gtgaccatca acagggtgat gggctatctg agctccgcca cgcgtgctag ctga           1674


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  41

Ala Gly Gln Leu Met 
1               5   


<210>  42
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  42

Arg Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Arg Thr 
            20  


<210>  43
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  termination sequence

<400>  43

Thr Arg Ala Ser 
1               


<210>  44
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary human Interleukin-15

<400>  44

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  45
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary human Interleukin-18

<400>  45

Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 
            20                  25                  30          


Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 
        35                  40                  45              


Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 
65                  70                  75                  80  


Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 
                85                  90                  95      


Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 
            100                 105                 110         


Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 
        115                 120                 125             


Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 
    130                 135                 140                 


Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp 
145                 150                 155         


<210>  46
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary single chain human Interleukin-12

<400>  46

Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro 
1               5                   10                  15      


Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu 
            20                  25                  30          


Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser 
        35                  40                  45              


Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln 
    50                  55                  60                  


Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu 
65                  70                  75                  80  


Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp 
                85                  90                  95      


Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn 
            100                 105                 110         


Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp 
        115                 120                 125             


Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly 
    130                 135                 140                 


Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp 
145                 150                 155                 160 


Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys 
                165                 170                 175     


Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala Val 
            180                 185                 190         


His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp 
        195                 200                 205             


Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys 
    210                 215                 220                 


Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser 
225                 230                 235                 240 


Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly 
                245                 250                 255     


Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser 
            260                 265                 270         


Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln 
        275                 280                 285             


Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys 
    290                 295                 300                 


Ser Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Arg Thr Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met 
                325                 330                 335     


Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn 
            340                 345                 350         


Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser 
        355                 360                 365             


Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val 
    370                 375                 380                 


Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn 
385                 390                 395                 400 


Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg 
                405                 410                 415     


Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp 
            420                 425                 430         


Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu 
        435                 440                 445             


Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val 
    450                 455                 460                 


Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro 
465                 470                 475                 480 


Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys 
                485                 490                 495     


Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp 
            500                 505                 510         


Arg Val Met Ser Tyr Leu Asn Ala Ser 
        515                 520     


<210>  47
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary human Interleukin-18

<400>  47

Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 
            20                  25                  30          


Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 
        35                  40                  45              


Ile Ser Ala Tyr Gly Asp Ser Arg Ala Arg Gly Lys Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 
65                  70                  75                  80  


Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 
                85                  90                  95      


Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 
            100                 105                 110         


Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 
        115                 120                 125             


Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 
    130                 135                 140                 


Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp 
145                 150                 155         


<210>  48
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  48
aactcgagcc gagctctgaa atggatgctt                                        30


<210>  49
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  49
aaccggttcc aatgagggag aagagggag                                         29


<210>  50
<211>  625
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IFNa

<400>  50
accggtcagt cctccgacag actgagtcgc ccggggggga tccaccggca tggctaggct       60

ctgtgctttc ctgatggtcc tggcggtgct gagctactgg ccaacctgct ctctaggatg      120

tgaccttcct cagactcata acctcaggaa caagagagcc ttgacactcc tggtacaaat      180

gaggagactc tcccctctct cctgcctgaa ggacaggaag gactttggat tcccgcagga      240

gaaggtggat gcccagcaga tcaagaaggc tcaagccatc cctgtcctga gtgagctgac      300

ccagcagatc ctgaacatct tcacatcaaa ggactcatct gctgcatgga atacaaccct      360

cctagactca ttctgcaatg acctccacca gcagctcaat gacctgcaag gctgtctgat      420

gcagcaggtg ggggtgcagg aatttcccct gacccaggaa gatgccctgc tggctgtgag      480

gaaatacttc cacaggatca ctgtgtacct gagagagaag aaacacagcc cctgtgcctg      540

ggaggtggtc agagcagaag tctggagagc cctgtcttcc tctgccaatg tgctgggaag      600

actgagagaa gagaaatgag tcgac                                            625


<210>  51
<211>  1188
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OVA

<400>  51
ggatccgcca ccatgggctc catcggcgca gcaagcatgg aattttgttt tgatgtattc       60

aaggagctca aagtccacca tgccaatgag aacatcttct actgccccat tgccatcatg      120

tcagctctag ccatggtata cctgggtgca aaagacagca ccaggacaca aataaataag      180

gttgttcgct ttgataaact tccaggattc ggagacagta ttgaagctca gtgtggcaca      240

tctgtaaacg ttcactcttc acttagagac atcctcaacc aaatcaccaa accaaatgat      300

gtttattcgt tcagccttgc cagtagactt tatgctgaag agagataccc aatcctgcca      360

gaatacttgc agtgtgtgaa ggaactgtat agaggaggct tggaacctat caactttcaa      420

acagctgcag atcaagccag agagctcatc aattcctggg tagaaagtca gacaaatgga      480

attatcagaa atgtccttca gccaagctcc gtggattctc aaactgcaat ggttctggtt      540

aatgccattg tcttcaaagg actgtgggag aaagcattta aggatgaaga cacacaagca      600

atgcctttca gagtgactga gcaagaaagc aaacctgtgc agatgatgta ccagattggt      660

ttatttagag tggcatcaat ggcttctgag aaaatgaaga tcctggagct tccatttgcc      720

agtgggacaa tgagcatgtt ggtgctgttg cctgatgaag tctcaggcct tgagcagctt      780

gagagtataa tcaactttga aaaactgact gaatggacca gttctaatgt tatggaagag      840

aggaagatca aagtgtactt acctcgcatg aagatggagg aaaaatacaa cctcacatct      900

gtcttaatgg ctatgggcat tactgacgtg tttagctctt cagccaatct gtctggcatc      960

tcctcagcag agagcctgaa gatatctcaa gctgtccatg cagcacatgc agaaatcaat     1020

gaagcaggca gagaggtggt agggtcagca gaggctggag tggatgctgc aagcgtctct     1080

gaagaattta gggctgacca tccattcctc ttctgtatca agcacatcgc aaccaacgcc     1140

gttctcttct ttggcagatg tgtttcccct ggcggcggct gagtcgac                  1188


<210>  52
<211>  1039
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated OVA

<400>  52
accggtccac aaagacagca ccatgacaca aataaataag gttgttcgct ttgataaact       60

tccaggattc ggagacagta ttgaagctca gtgtggcaca tctgtaaacg ttcactcttc      120

acttagagac atcctcaacc aaatcaccaa accaaatgat gtttattcgt tcagccttgc      180

cagtagactt tatgctgaag agagataccc aatcctgcca gaatacttgc agtgtgtgaa      240

ggaactgtat agaggaggct tggaacctat caactttcaa acagctgcag atcaagccag      300

agagctcatc aattcctggg tagaaagtca gacaaatgga attatcagaa atgtccttca      360

gccaagctcc gtggattctc aaactgcaat ggttctggtt aatgccattg tcttcaaagg      420

actgtgggag aaagcattta aggatgaaga cacacaagca atgcctttca gagtgactga      480

gcaagaaagc aaacctgtgc agatgatgta ccagattggt ttatttagag tggcatcaat      540

ggcttctgag aaaatgaaga tcctggagct tccatttgcc agtgggacaa tgagcatgtt      600

ggtgctgttg cctgatgaag tctcaggcct tgagcagctt gagagtataa tcaactttga      660

aaaactgact gaatggacca gttctaatgt tatggaagag aggaagatca aagtgtactt      720

acctcgcatg aagatggagg aaaaatacaa cctcacatct gtcttaatgg ctatgggcat      780

tactgacgtg tttagctctt cagccaatct gtctggcatc tcctcagcag agagcctgaa      840

gatatctcaa gctgtccatg cagcacatgc agaaatcaat gaagcaggca gagaggtggt      900

agggtcagca gaggctggag tggatgctgc aagcgtctct gaagaattta gggctgacca      960

tccattcctc ttctgtatca agcacatcgc aaccaacgcc gttctcttct ttggcagatg     1020

tgtttcccct taagtcgac                                                  1039


<210>  53
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  53
tactgacgct ctcgcacc                                                     18


<210>  54
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  54
tctcgacgca ggactcg                                                      17


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ATCTCTCTCCTTCTAGCCTC

<400>  55
atctctctcc ttctagcctc                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  56
accgattcca gatgattggc                                                   20


<210>  57
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  57
tccatattaa tgcagtgctt gc                                                22


<210>  58
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  58
agaggcctgt cctgcagctc atgg                                              24


