                         SEQUENCE LISTING

<110>  Microbio (Shanghai) Co. Ltd.
 
<120>  INTERFERING RNAS TARGETING SEVERE ACUTE RESPIRATORY 
       SYNDROME-ASSOCIATED CORONAVIRUS AND USES THEREOF FOR TREATING 
       COVID-19

<130>  112319-0025-70001WO3

<140>  PCT/CN2021/135476
<141>  2021-12-03

<150>  PCT/CN2021/121762
<151>  2021-09-29

<150>  PCT/CN2020/133565
<151>  2020-12-03

<160>  75    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
uaagauguug acgugccucu u                                                 21


<210>  2
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
gaggcacguc aacaucuua                                                    19


<210>  3
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
uuagugugau uuaaugcugu u                                                 21


<210>  4
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
cagcauuaaa ucacacuaa                                                    19


<210>  5
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
aaacacgguu uaaacaccgu u                                                 21


<210>  6
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
cgguguuuaa accguguuu                                                    19


<210>  7
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
uuaaguguag uuguaccacu u                                                 21


<210>  8
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
gugguacaac uacacuuaa                                                    19


<210>  9
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
aaacuacguc aucaagccau u                                                 21


<210>  10
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
uggcuugaug acguaguuu                                                    19


<210>  11
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
aaauuaccgg guuugacagu u                                                 21


<210>  12
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
cugucaaacc cgguaauuu                                                    19


<210>  13
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
uuaacauaua gugaaccgcu u                                                 21


<210>  14
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
gcgguucacu auauguuaa                                                    19


<210>  15
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
uugacuagag acuaguggcu u                                                 21


<210>  16
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
gccacuaguc ucuagucag                                                    19


<210>  17
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
uaaacacgcc aaguaggagu u                                                 21


<210>  18
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
cuccuacuug gcguguuua                                                    19


<210>  19
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
ucuuaguuag caaugugcgu u                                                 21


<210>  20
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
cgcacauugc uaacuaagg                                                    19


<210>  21
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
uuaacuauua acguaccugu u                                                 21


<210>  22
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
cagguacguu aauaguuaa                                                    19


<210>  23
<211>  40
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
uugcuuuuca aacugucaaa cccgguaauu uuaacaaaga                             40


<210>  24
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
uuucaaacug ucaaacccgg uaauuuu                                           27


<210>  25
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or u

<400>  25
gaggcacguc aacaucuun                                                    19


<210>  26
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or u

<400>  26
naagauguug acgugccucn n                                                 21


<210>  27
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or u

<400>  27
cagcauuaaa ucacacuan                                                    19


<210>  28
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or u

<400>  28
nuagugugau uuaaugcugn n                                                 21


<210>  29
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or u

<400>  29
cgguguuuaa accguguun                                                    19


<210>  30
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or u

<400>  30
naacacgguu uaaacaccgn n                                                 21


<210>  31
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or u

<400>  31
gugguacaac uacacuuan                                                    19


<210>  32
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or u

<400>  32
nuaaguguag uuguaccacn n                                                 21


<210>  33
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or u

<400>  33
uggcuugaug acguaguun                                                    19


<210>  34
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or u

<400>  34
naacuacguc aucaagccan n                                                 21


<210>  35
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or u

<400>  35
cugucaaacc cgguaauun                                                    19


<210>  36
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or u

<400>  36
naauuaccgg guuugacagn n                                                 21


<210>  37
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or u

<400>  37
gcgguucacu auauguuan                                                    19


<210>  38
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or u

<400>  38
nuaacauaua gugaaccgcn n                                                 21


<210>  39
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or u

<400>  39
gccacuaguc ucuagucan                                                    19


<210>  40
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or u

<400>  40
nugacuagag acuaguggcn n                                                 21


<210>  41
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or u

<400>  41
cuccuacuug gcguguuun                                                    19


<210>  42
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or u

<400>  42
naaacacgcc aaguaggagn n                                                 21


<210>  43
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or u

<400>  43
cgcacauugc uaacuaagn                                                    19


<210>  44
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or u

<400>  44
ncuuaguuag caaugugcgn n                                                 21


<210>  45
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or u

<400>  45
cagguacguu aauaguuan                                                    19


<210>  46
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or u

<400>  46
nuaacuauua acguaccugn n                                                 21


<210>  47
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<400>  47
naagauguug acgugccucu u                                                 21


<210>  48
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<400>  48
nuagugugau uuaaugcugu u                                                 21


<210>  49
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<400>  49
naacacgguu uaaacaccgu u                                                 21


<210>  50
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<400>  50
nuaaguguag uuguaccacu u                                                 21


<210>  51
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<400>  51
naacuacguc aucaagccau u                                                 21


<210>  52
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<400>  52
naauuaccgg guuugacagu u                                                 21


<210>  53
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<400>  53
nuaacauaua gugaaccgcu u                                                 21


<210>  54
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<400>  54
nugacuagag acuaguggcu u                                                 21


<210>  55
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<400>  55
naaacacgcc aaguaggagu u                                                 21


<210>  56
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<400>  56
ncuuaguuag caaugugcgu u                                                 21


<210>  57
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<400>  57
nuaacuauua acguaccugu u                                                 21


<210>  58
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
uugacaguuu gggccauuaa a                                                 21


<210>  59
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59
auguugcuuu ucaaacuguc aaacccggua auuuuaacaa agacuucuau                  50


<210>  60
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
agggucaggc agggggccgg                                                   20


<210>  61
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61
acuaacaaug uugcuuuuca aacugucaaa cccgguaauu uuaacaaaga cuucuau          57


<210>  62
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62
acaggtacgt taatagttaa tagcgt                                            26


<210>  63
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63
acattgcagc agtacgcaca ca                                                22


<210>  64
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64
acactagcca tccttactgc gcttcg                                            26


<210>  65
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65
gtcgtatcca gtgcagggtc cgaggtattc gcactggata cgacaactgt ca               52


<210>  66
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66
aagcgcctaa attaccgggt t                                                 21


<210>  67
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67
gtgcagggtc cgaggt                                                       16


<210>  68
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  modified with phosphorothioate

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(19)
<223>  modified with 2'-O-methylation

<400>  68
cugucaaacc cgguaauuu                                                    19


<210>  69
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  modified with phosphorothioate

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  modified with phosphorothioate

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  modified with 2'-O-methylation

<400>  69
aaauuaccgg guuugacagu u                                                 21


<210>  70
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  modified with phosphorothioate

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(19)
<223>  modified with 2'-O-methylation

<400>  70
gccacuaguc ucuagucaa                                                    19


<210>  71
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  modified with phosphorothioate

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  modified with phosphorothioate

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  modified with phosphorothioate

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  modified with 2'-O-methylation

<400>  71
uugacuagag acuaguggcu u                                                 21


<210>  72
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  modified with phosphorothioate

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(19)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  modified with phosphorothioate

<400>  72
cgcacauugc uaacuaaga                                                    19


<210>  73
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  modified with phosphorothioate

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  modified with 2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(21)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  modified with phosphorothioate

<400>  73
ucuuaguuag caaugugcgu u                                                 21


<210>  74
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74
gccacuaguc ucuagucaa                                                    19


<210>  75
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75
cgcacauugc uaacuaaga                                                    19


