                   б

<110>  ݿƼ޹˾

<120>  CD70Ŀԭϵ׼Ӧ

<130>  0141-PA-025

<160>  94

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1C HCDR1H3 HCDR1;1H HCDR1

<400>  1

Gly Lys Pro Phe Ser Phe Tyr Phe 
1               5               


<210>  2
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1C HCDR2;H3 HCDR2;1H HCDR2

<400>  2

Ile Thr Gly Asp Gly Met Thr 
1               5           


<210>  3
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> 1C HCDR3

<400>  3

Tyr Ala Asp Ala Trp Ala Gly Ala Gly Arg Glu Glu Tyr 
1               5                   10              


<210>  4
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H3 HCDR3

<400>  4

Tyr Ala Asp Ala Trp Ala Gly Ala Val Arg Ala Glu Tyr 
1               5                   10              


<210>  5
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1H HCDR3

<400>  5

Tyr Ala Asp Val Trp Ala Gly Ala Gly Arg Asp Glu Tyr 
1               5                   10              


<210>  6
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1F HCDR1

<400>  6

Gly Lys Arg Phe Ser Phe Tyr Phe 
1               5               


<210>  7
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1F HCDR2;5H HCDR2

<400>  7

Ile Thr Gly Asp Gly Arg Thr 
1               5           


<210>  8
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> 1F HCDR3

<400>  8

Tyr Ala Asp Ala Phe Ala Gly Ala Gly Arg Asp Glu Tyr 
1               5                   10              


<210>  9
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> 5H HCDR1

<400>  9

Gly Lys Ile Phe Ser Phe Tyr Phe 
1               5               


<210>  10
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5H HCDR3

<400>  10

Tyr Ala Asp Val Phe Ala Arg Ala Gly Arg Asp Glu Tyr 
1               5                   10              


<210>  11
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> 3H HCDR1

<400>  11

Gly Asn Ile Leu Arg Phe Asn Ala 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3H HCDR2

<400>  12

Met Ala Gly Ala Arg Thr Asn Tyr 
1               5               


<210>  13
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3H HCDR3

<400>  13

Asp Arg Val Tyr Gly Pro Pro Tyr Glu Tyr 
1               5                   10  


<210>  14
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1G HCDR1

<400>  14

Ser Gly Ile Ile Phe Asn Ser Asp 
1               5               


<210>  15
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1G HCDR2

<400>  15

Leu Thr Ser Asn Met Arg Thr 
1               5           


<210>  16
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> 1G HCDR3

<400>  16

Asn Val Asn Arg Met Thr Ser Tyr Gly Pro Arg Asp Tyr 
1               5                   10              


<210>  17
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> L1 HCDR1

<400>  17

Gly Arg Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L1 HCDR2

<400>  18

Ile Asn Trp Ser Asp Gly Ser Thr 
1               5               


<210>  19
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L1 HCDR3

<400>  19

Ala Ala Gly Cys Cys Gly Val Ala Asp Ala Pro Leu Asn Ala Leu Asp 
1               5                   10                  15      


Ala 
    


<210>  20
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5A HCDR1

<400>  20

Glu Ser Ile Phe Asn Asn Tyr Val 
1               5               


<210>  21
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> 5A HCDR2

<400>  21

Ile Ser Thr Asp Gly Ser Ala 
1               5           


<210>  22
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> 5A HCDR3

<400>  22

Thr Ala Gly Leu Gln Tyr 
1               5       


<210>  23
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> 7D HCDR1;5B HCDR1

<400>  23

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  7D HCDR2

<400>  24

Ile Arg Arg Ser Asp Gly Ser Thr 
1               5               


<210>  25
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  7D HCDR3

<400>  25

Ala Val Asp Arg Tyr Gly Gln Ser Trp His Glu Gly Arg Gly Ala Leu 
1               5                   10                  15      


Asp Ala 
        


<210>  26
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> L2 HCDR1

<400>  26

Gly Phe Thr Val Asp Asp Tyr Val 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> L2 HCDR2

<400>  27

Ile Ser Ser Asn Asp Gly Ser Thr 
1               5               


<210>  28
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L2 HCDR3

<400>  28

Ala Ala Lys Tyr Ala Pro Tyr Gly Leu Glu Tyr Trp Glu Gly Gly Met 
1               5                   10                  15      


Asp Tyr 
        


<210>  29
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1E HCDR1

<400>  29

Gly Phe Ala Phe Asp Asp Tyr Ala 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> 1E HCDR2

<400>  30

Met Ser Ser Ser Asp Gly Ser Thr 
1               5               


<210>  31
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> 1E HCDR3

<400>  31

Ala Ala Gly Val Asn Tyr Tyr Arg Glu Asp Gly Cys Pro Gly Ala Leu 
1               5                   10                  15      


Asp Tyr 
        


<210>  32
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5B HCDR2

<400>  32

Phe Arg Ser Ser Asp Gly Asn Ile 
1               5               


<210>  33
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5B HCDR3

<400>  33

Ala Ala Tyr Ser Val Leu Leu Arg Pro Trp Val Leu Cys Glu Gly Ser 
1               5                   10                  15      


Tyr Asp Tyr 
            


<210>  34
<211>  119
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-1C

<400>  34

Glu Val Gln Val Val Glu Ser Gly Gly Gly Met Val Gln Ala Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Lys Pro Phe Ser Phe Tyr 
            20                  25                  30          


Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Gly Asp Gly Met Thr Asn Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Asp Ala Trp Ala Gly Ala Gly Arg Glu Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Ser Val Ser Ser 
        115                 


<210>  35
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-1E

<400>  35

Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Arg Val 
        35                  40                  45              


Ser Cys Met Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Val Asn Tyr Tyr Arg Glu Asp Gly Cys Pro Gly Ala Leu 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  36
<211>  119
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-1F

<400>  36

Glu Val Gln Val Val Glu Ser Gly Gly Gly Met Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Lys Arg Phe Ser Phe Tyr 
            20                  25                  30          


Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Gly Asp Gly Arg Thr Asn Tyr Ala Gly Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Met Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Asp Ala Phe Ala Gly Ala Gly Arg Asp Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Ser Val Ser Ser 
        115                 


<210>  37
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-1G

<400>  37

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Leu Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Thr Ala Ser Gly Ile Ile Phe Asn Ser Asp 
            20                  25                  30          


Tyr Val Gly Trp Tyr Arg Gln Ala Pro Gly Ser Asp Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Thr Ser Asn Met Arg Thr Asn Tyr Ala Asp Ser Val Glu Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val 
                85                  90                  95      


Asn Arg Met Thr Ser Tyr Gly Pro Arg Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  38
<211>  119
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-1H

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Lys Pro Phe Ser Phe Tyr 
            20                  25                  30          


Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Gly Asp Gly Met Thr Asn Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Asp Val Trp Ala Gly Ala Gly Arg Asp Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Arg Val Thr Val Ser Ser 
        115                 


<210>  39
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-3H

<400>  39

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Leu Arg Phe Asn 
            20                  25                  30          


Ala Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Ala Met Ala Gly Ala Arg Thr Asn Tyr Ala Asp Ser Val Glu Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Gly Asn Asn Ala Asn Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Gly Ala 
                85                  90                  95      


Asp Arg Val Tyr Gly Pro Pro Tyr Glu Tyr Gly Gly Arg Gly Thr Gln 
            100                 105                 110         


Val Thr Val Leu Ser 
        115         


<210>  40
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-5A

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Ser Ile Phe Asn Asn Tyr 
            20                  25                  30          


Val Met Ala Trp Tyr Arg Gln Pro Pro Gly Lys Gln Arg Glu Ala Val 
        35                  40                  45              


Ala Gln Ile Ser Thr Asp Gly Ser Ala Tyr Tyr Gln Asp Arg Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Leu Val Asn Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ala Gly Leu Gln Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  41
<211>  126
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-5B

<400>  41

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Pro Glu Gly Val 
        35                  40                  45              


Ser Cys Phe Arg Ser Ser Asp Gly Asn Ile Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Tyr Ser Val Leu Leu Arg Pro Trp Val Leu Cys Glu Gly Ser 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  42
<211>  119
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-5H

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Lys Ile Phe Ser Phe Tyr 
            20                  25                  30          


Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Gly Asp Gly Arg Thr Asn Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Asp Val Phe Ala Arg Ala Gly Arg Asp Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Ser Val Ser Ser 
        115                 


<210>  43
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-7D

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Arg Ser Asp Gly Ser Thr Trp Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Asn Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Asp Arg Tyr Gly Gln Ser Trp His Glu Gly Arg Gly Ala Leu 
            100                 105                 110         


Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  44
<211>  119
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-H3

<400>  44

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Ala Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Lys Pro Phe Ser Phe Tyr 
            20                  25                  30          


Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Thr Gly Asp Gly Met Thr Asn Tyr Ala Asp Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Asp Ala Trp Ala Gly Ala Val Arg Ala Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Ser Val Ser Ser 
        115                 


<210>  45
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-L2

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Asp Asp Tyr 
            20                  25                  30          


Val Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Asn Asp Gly Ser Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Tyr Ala Pro Tyr Gly Leu Glu Tyr Trp Glu Gly Gly Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  46
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-L1

<400>  46

Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Asp Gln Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Lys Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Cys Cys Gly Val Ala Asp Ala Pro Leu Asn Ala Leu Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  47
<211>  357
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-1C

<400>  47
gaggtgcagg tggtggagtc ggggggagga atggtgcagg ctgggcgatc tctgagactc       60

tcctgtgctg cctctggaaa gcccttcagt ttctatttca tgggatggta tcgccaggct      120

ccaggaaacc agcgcgagtt ggtcgccctt attaccggtg atggtatgac aaactatgca      180

gactccgtgg agggccgatt caccatctcc agagacaacg ccaagaatac aatgtatctc      240

gaaatgaaca gcctgaaacc tgaggacaca gccgtctatt attgctatgc agatgcttgg      300

gcgggggccg gccgcgaaga gtactggggc caggggaccc aggtcagcgt ctcctca         357


<210>  48
<211>  375
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-1E

<400>  48
gaggtgcagg tggtggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cgctttcgat gattatgcca taggctggtt ccgccaggcc      120

ccagggaagg agcaggaaag agtctcatgt atgagtagta gtgatggtag cacatactat      180

gcagactccg tgaagggccg attcaccatc tccagtgaca acgccaagaa cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc cgcaggggtc      300

aattactatc gcgaggatgg gtgcccgggc gcgttggact actggggcca ggggacccag      360

gtcaccgtct cctca                                                       375


<210>  49
<211>  357
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-1F

<400>  49
gaggtgcagg tggtggagtc ggggggagga atggtgcagg ctgggggatc tctgaggctc       60

tcctgtgcag cctctggaaa gcgcttcagt ttctatttta tgggatggta ccgccaggct      120

ccaggaaagc agcgcgagtt ggtcgccctt attactggtg atggcaggac aaactatgca      180

gggtccgtgg agggccgatt caccatctcc agagacaacg ccaagaacac gctatatctg      240

caaatgaaca gcatgaaacc tgaggacaca gccgtctatt attgctatgc agatgcattc      300

gcgggggccg gccgcgatga gtactggggc caggggaccc aggtcagcgt ctcctca         357


<210>  50
<211>  354
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-1G

<400>  50
cagttgcagc tcgtggagtc cgggggaggc ttggtgcaac ttggggggtc tctgacgctc       60

tcctgtacag cctctgggat tatcttcaat agcgattacg tgggctggta ccgccaggct      120

ccagggtcgg atcgcgagtt ggtcgcactt actagtaata tgaggacaaa ctatgcagac      180

tccgtggagg gccgattcac catctccaga gacaacgcca agaatacggt gtatctgcaa      240

atgaacagcc tgaaacctga ggacacggcc gtctattatt gtaatgtaaa tagaatgacc      300

tcctatgggc ctcgggacta ctggggccag gggacccagg tcaccgtctc ctcc            354


<210>  51
<211>  357
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-1H

<400>  51
gaggtgcagc tggtggagtc tggtggagga atggtgcagg ctgggggatc tctgagactc       60

tcctgtgctg cctctggaaa gcccttcagt ttctatttca tgggatggta ccgccaggct      120

ccaggaaagc agcgcgagtt ggtcgccctt attaccggtg atggtatgac aaactatgca      180

gactccgtgg agggccgatt caccatctcc agagacaacg ccaagaacac aatgtatctg      240

caaatgaaca gcctgaaacc tgaggacaca gccgtctatt attgctatgc agatgtatgg      300

gcgggggccg gccgcgatga gtactggggc caggggaccc gggtcaccgt ctcctca         357


<210>  52
<211>  351
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-3H

<400>  52
cagttgcagc tcgtggagtc gggtggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaaa catcctcaga ttcaatgccg tgggctggta ccgccaggct      120

ccagggaagc agcgcgactt ggtcgcggct atggctggtg cacggacaaa ctatgcagac      180

tccgtggagg gccgattcac catctccgga aacaacgcca acaacacggt ttatctgcaa      240

atgaacagcc tgaaacctga agacacaggc gtctactact gtggtgctga ccgcgtatat      300

ggtccgccgt atgaatatgg gggccggggg acccaggtca ccgtcttgtc a               351


<210>  53
<211>  336
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-5A

<400>  53
gaggtgcagc tggtggagtc ggggggaggc ttggtgcagg ctggggggtc tctgaggctc       60

tcctgtgcag cctctgaaag catcttcaat aattatgtca tggcctggta ccgccagcct      120

ccagggaagc agcgcgaggc ggtcgcacaa attagtactg atggtagtgc gtactatcag      180

gaccgagtga agggccgatt cactatctcc agagacaacg ccaagaactt ggtgaatctg      240

caaatgagca gcctgaaacc tgaggacaca gccgtctatt actgtactgc aggtctccag      300

tactggggcc aggggaccca ggtcaccgtc tcctca                                336


<210>  54
<211>  378
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-5B

<400>  54
caggtgcagc tcgtggagtc tggaggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cactttcgat gattatgcca taggctggtt ccgccaggcc      120

ccagggaagg agcctgaggg ggtctcatgt ttcaggagta gtgatggtaa catatactat      180

tcagactccg tgaggggccg attcaccatc tccagtgaca acgccaagaa cacggtgtat      240

ctgcaaatga acagactgaa acctgaggac acggccgttt actactgtgc agcctatagc      300

gtactgctca ggccctgggt gttatgtgaa ggctcatatg actactgggg ccaggggacc      360

caggtcaccg tctcctca                                                    378


<210>  55
<211>  357
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-5H

<400>  55
gaggtgcagc tggtggagtc agggggaggt atggtgcagg ctgggggatc tctgagactc       60

tcctgtgcag cccctggaaa gatcttcagt ttctatttca tgggatggta ccgccaggct      120

ccaggaaagc agcgcgagtt ggtcgccctt attaccggtg atggtaggac aaactatgca      180

gactccgtgg agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaaca gcctgaaacc tgaggacaca gccgtctatt attgctatgc agatgtattt      300

gcgagggccg gccgcgatga gtactggggc caggggaccc aggtcagcgt ctcctca         357


<210>  56
<211>  375
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-7D

<400>  56
gaggtgcagc tggtggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cactttcgat gattatgcca taggctggtt ccgccaggcc      120

ccagggaagg agcaagaggg ggtctcatgt attagacgta gtgatggtag cacatggtat      180

gcaaactccg tgaagggccg attcaccatc tccaatgaca acgccaagaa cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgcgc agtagatcgt      300

tacggtcaga gttggcacga gggccgcggc gctttggacg catggggcca ggggaccctg      360

gtcactgtct cctca                                                       375


<210>  57
<211>  357
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-H3

<400>  57
caggtgcagc tcgtggagtc tgggggagga atggtgcagg ctgggcgatc tctgagactc       60

tcctgtgctg cctctggaaa gcccttcagt ttctatttca tgggatggta tcgccaggct      120

ccaggaaagg agcgcgagtt ggtcgccctt attaccggtg atggtatgac aaactatgca      180

gactccgtgg agggccgatt caccatctcc agagacaacg ccaagaatac attgtatctc      240

gaaatgaaca gcctgaaacc tgaggacaca gccgtctatt attgctatgc agatgcttgg      300

gcgggggccg ttcgcgccga gtactggggc caggggaccc aggtcagcgt ctcctca         357


<210>  58
<211>  375
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-L2

<400>  58
gaggtgcagc tggtggagtc cgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cactgtcgat gattatgtca taggctggtt ccgccaggcc      120

ccagggaagg agcatgaggg ggtctcatgt attagtagta atgatggtag tacatggtat      180

gcagactccg tgaagggccg attcaccatc tccagtgaca acgccaagaa cacgatgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agctaaatac      300

gcaccctacg ggttggagta ctgggaggga ggcatggact actggggcaa agggaccctg      360

gtcaccgtct cctca                                                       375


<210>  59
<211>  372
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-sdAb-L1

<400>  59
gaggtgcagg tggtggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgtgcag cctctggacg caccttcagt tcatatgcca tgggctgggt ccgccaggct      120

ccagggaagg accaagagtt tgtagcggct attaactgga gtgatggtag cacatactat      180

gcagactccg tgaagggccg attcaccatc gccagagaca acgccaagaa cacggcgttt      240

ctgcaaatga acagcctgaa acctgaggac acggccgtgt attactgtgc agcagggtgt      300

tgcggagtag ctgatgcccc cctcaatgct ttggacgcat ggggccaggg gaccctggtc      360

actgtctcct ca                                                          372


<210>  60
<211>  363
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-1C

<400>  60

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Val Val Glu Ser Gly Gly Gly Met 
            20                  25                  30          


Val Gln Ala Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Lys 
        35                  40                  45              


Pro Phe Ser Phe Tyr Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn 
    50                  55                  60                  


Gln Arg Glu Leu Val Ala Leu Ile Thr Gly Asp Gly Met Thr Asn Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Met Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Tyr Ala Asp Ala Trp Ala Gly Ala Gly Arg Glu Glu 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Gln Val Ser Val Ser Ser Thr Thr Thr Pro 
    130                 135                 140                 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
145                 150                 155                 160 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
                165                 170                 175     


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
            180                 185                 190         


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
        195                 200                 205             


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
    210                 215                 220                 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
225                 230                 235                 240 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
                245                 250                 255     


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
            260                 265                 270         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        275                 280                 285             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    290                 295                 300                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
305                 310                 315                 320 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                325                 330                 335     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            340                 345                 350         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360             


<210>  61
<211>  369
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-1E

<400>  61

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Ala Phe Asp Asp Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Gln Glu Arg Val Ser Cys Met Ser Ser Ser Asp Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Gly Val Asn Tyr Tyr Arg Glu Asp Gly 
        115                 120                 125             


Cys Pro Gly Ala Leu Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    130                 135                 140                 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
145                 150                 155                 160 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                165                 170                 175     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        195                 200                 205             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    210                 215                 220                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
225                 230                 235                 240 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                245                 250                 255     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            260                 265                 270         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        275                 280                 285             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    290                 295                 300                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
305                 310                 315                 320 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                325                 330                 335     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            340                 345                 350         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        355                 360                 365             


Arg 
    


<210>  62
<211>  363
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-1F

<400>  62

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Val Val Glu Ser Gly Gly Gly Met 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Lys 
        35                  40                  45              


Arg Phe Ser Phe Tyr Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gln Arg Glu Leu Val Ala Leu Ile Thr Gly Asp Gly Arg Thr Asn Tyr 
65                  70                  75                  80  


Ala Gly Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Met Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Tyr Ala Asp Ala Phe Ala Gly Ala Gly Arg Asp Glu 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Gln Val Ser Val Ser Ser Thr Thr Thr Pro 
    130                 135                 140                 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
145                 150                 155                 160 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
                165                 170                 175     


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
            180                 185                 190         


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
        195                 200                 205             


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
    210                 215                 220                 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
225                 230                 235                 240 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
                245                 250                 255     


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
            260                 265                 270         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        275                 280                 285             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    290                 295                 300                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
305                 310                 315                 320 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                325                 330                 335     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            340                 345                 350         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360             


<210>  63
<211>  362
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-1G

<400>  63

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Leu Gly Gly Ser Leu Thr Leu Ser Cys Thr Ala Ser Gly Ile 
        35                  40                  45              


Ile Phe Asn Ser Asp Tyr Val Gly Trp Tyr Arg Gln Ala Pro Gly Ser 
    50                  55                  60                  


Asp Arg Glu Leu Val Ala Leu Thr Ser Asn Met Arg Thr Asn Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Asn Val Asn Arg Met Thr Ser Tyr Gly Pro Arg Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
    130                 135                 140                 


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
145                 150                 155                 160 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                165                 170                 175     


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            180                 185                 190         


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        195                 200                 205             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    210                 215                 220                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
225                 230                 235                 240 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                245                 250                 255     


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
            260                 265                 270         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        275                 280                 285             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    290                 295                 300                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
305                 310                 315                 320 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                325                 330                 335     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            340                 345                 350         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360         


<210>  64
<211>  363
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-1H

<400>  64

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Met 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Lys 
        35                  40                  45              


Pro Phe Ser Phe Tyr Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gln Arg Glu Leu Val Ala Leu Ile Thr Gly Asp Gly Met Thr Asn Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Tyr Ala Asp Val Trp Ala Gly Ala Gly Arg Asp Glu 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser Thr Thr Thr Pro 
    130                 135                 140                 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
145                 150                 155                 160 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
                165                 170                 175     


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
            180                 185                 190         


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
        195                 200                 205             


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
    210                 215                 220                 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
225                 230                 235                 240 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
                245                 250                 255     


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
            260                 265                 270         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        275                 280                 285             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    290                 295                 300                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
305                 310                 315                 320 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                325                 330                 335     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            340                 345                 350         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360             


<210>  65
<211>  361
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-3H

<400>  65

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Ile Leu Arg Phe Asn Ala Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gln Arg Asp Leu Val Ala Ala Met Ala Gly Ala Arg Thr Asn Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Gly Asn Asn Ala Asn Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val 
            100                 105                 110         


Tyr Tyr Cys Gly Ala Asp Arg Val Tyr Gly Pro Pro Tyr Glu Tyr Gly 
        115                 120                 125             


Gly Arg Gly Thr Gln Val Thr Val Leu Ser Thr Thr Thr Pro Ala Pro 
    130                 135                 140                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
145                 150                 155                 160 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                165                 170                 175     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            180                 185                 190         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        195                 200                 205             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    210                 215                 220                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
225                 230                 235                 240 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                245                 250                 255     


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            260                 265                 270         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        275                 280                 285             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    290                 295                 300                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
305                 310                 315                 320 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                325                 330                 335     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            340                 345                 350         


Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360     


<210>  66
<211>  356
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-5A

<400>  66

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Ser 
        35                  40                  45              


Ile Phe Asn Asn Tyr Val Met Ala Trp Tyr Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Gln Arg Glu Ala Val Ala Gln Ile Ser Thr Asp Gly Ser Ala Tyr Tyr 
65                  70                  75                  80  


Gln Asp Arg Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Leu Val Asn Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Thr Ala Gly Leu Gln Tyr Trp Gly Gln Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    130                 135                 140                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
145                 150                 155                 160 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                165                 170                 175     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            180                 185                 190         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        195                 200                 205             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    210                 215                 220                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
225                 230                 235                 240 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                245                 250                 255     


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            260                 265                 270         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        275                 280                 285             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    290                 295                 300                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
305                 310                 315                 320 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                325                 330                 335     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            340                 345                 350         


Leu Pro Pro Arg 
        355     


<210>  67
<211>  370
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-5B

<400>  67

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Asp Asp Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Pro Glu Gly Val Ser Cys Phe Arg Ser Ser Asp Gly Asn Ile Tyr 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Arg Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Tyr Ser Val Leu Leu Arg Pro Trp Val 
        115                 120                 125             


Leu Cys Glu Gly Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
    130                 135                 140                 


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
145                 150                 155                 160 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
                165                 170                 175     


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
            180                 185                 190         


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
        195                 200                 205             


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
    210                 215                 220                 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
225                 230                 235                 240 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
                245                 250                 255     


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
            260                 265                 270         


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        275                 280                 285             


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    290                 295                 300                 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
305                 310                 315                 320 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                325                 330                 335     


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            340                 345                 350         


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        355                 360                 365             


Pro Arg 
    370 


<210>  68
<211>  363
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-5H

<400>  68

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Met 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Lys 
        35                  40                  45              


Ile Phe Ser Phe Tyr Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gln Arg Glu Leu Val Ala Leu Ile Thr Gly Asp Gly Arg Thr Asn Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Tyr Ala Asp Val Phe Ala Arg Ala Gly Arg Asp Glu 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Gln Val Ser Val Ser Ser Thr Thr Thr Pro 
    130                 135                 140                 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
145                 150                 155                 160 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
                165                 170                 175     


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
            180                 185                 190         


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
        195                 200                 205             


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
    210                 215                 220                 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
225                 230                 235                 240 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
                245                 250                 255     


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
            260                 265                 270         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        275                 280                 285             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    290                 295                 300                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
305                 310                 315                 320 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                325                 330                 335     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            340                 345                 350         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360             


<210>  69
<211>  369
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-7D

<400>  69

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Asp Asp Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Gln Glu Gly Val Ser Cys Ile Arg Arg Ser Asp Gly Ser Thr Trp 
65                  70                  75                  80  


Tyr Ala Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Asn Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Val Asp Arg Tyr Gly Gln Ser Trp His Glu 
        115                 120                 125             


Gly Arg Gly Ala Leu Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
145                 150                 155                 160 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                165                 170                 175     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        195                 200                 205             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    210                 215                 220                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
225                 230                 235                 240 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                245                 250                 255     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            260                 265                 270         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        275                 280                 285             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    290                 295                 300                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
305                 310                 315                 320 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                325                 330                 335     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            340                 345                 350         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        355                 360                 365             


Arg 
    


<210>  70
<211>  363
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-H3

<400>  70

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Met 
            20                  25                  30          


Val Gln Ala Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Lys 
        35                  40                  45              


Pro Phe Ser Phe Tyr Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Leu Val Ala Leu Ile Thr Gly Asp Gly Met Thr Asn Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Tyr Ala Asp Ala Trp Ala Gly Ala Val Arg Ala Glu 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Gln Val Ser Val Ser Ser Thr Thr Thr Pro 
    130                 135                 140                 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
145                 150                 155                 160 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
                165                 170                 175     


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
            180                 185                 190         


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
        195                 200                 205             


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
    210                 215                 220                 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
225                 230                 235                 240 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
                245                 250                 255     


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
            260                 265                 270         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        275                 280                 285             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    290                 295                 300                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
305                 310                 315                 320 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                325                 330                 335     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            340                 345                 350         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360             


<210>  71
<211>  369
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-L2

<400>  71

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Val Asp Asp Tyr Val Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu His Glu Gly Val Ser Cys Ile Ser Ser Asn Asp Gly Ser Thr Trp 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Lys Tyr Ala Pro Tyr Gly Leu Glu Tyr 
        115                 120                 125             


Trp Glu Gly Gly Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
145                 150                 155                 160 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                165                 170                 175     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        195                 200                 205             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    210                 215                 220                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
225                 230                 235                 240 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                245                 250                 255     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            260                 265                 270         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        275                 280                 285             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    290                 295                 300                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
305                 310                 315                 320 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                325                 330                 335     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            340                 345                 350         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        355                 360                 365             


Arg 
    


<210>  72
<211>  368
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-L1

<400>  72

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
        35                  40                  45              


Thr Phe Ser Ser Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Asp Gln Glu Phe Val Ala Ala Ile Asn Trp Ser Asp Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Ala Phe Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Gly Cys Cys Gly Val Ala Asp Ala Pro 
        115                 120                 125             


Leu Asn Ala Leu Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
145                 150                 155                 160 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                165                 170                 175     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            180                 185                 190         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        195                 200                 205             


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    210                 215                 220                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
225                 230                 235                 240 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            260                 265                 270         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        275                 280                 285             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    290                 295                 300                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
305                 310                 315                 320 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                325                 330                 335     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            340                 345                 350         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365             


<210>  73
<211>  1089
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-1C

<400>  73
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc aggtggtgga gtcgggggga ggaatggtgc aggctgggcg atctctgaga      120

ctctcctgtg ctgcctctgg aaagcccttc agtttctatt tcatgggatg gtatcgccag      180

gctccaggaa accagcgcga gttggtcgcc cttattaccg gtgatggtat gacaaactat      240

gcagactccg tggagggccg attcaccatc tccagagaca acgccaagaa tacaatgtat      300

ctcgaaatga acagcctgaa acctgaggac acagccgtct attattgcta tgcagatgct      360

tgggcggggg ccggccgcga agagtactgg ggccagggga cccaggtcag cgtctcctca      420

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      480

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      540

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      600

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc      660

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga      720

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac      780

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      840

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      900

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      960

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1020

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1080

ccccctcgc                                                             1089


<210>  74
<211>  1107
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-1E

<400>  74
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc aggtggtgga gtctggggga ggcttggtgc aggctggggg gtctctgaga      120

ctctcctgtg cagcctctgg attcgctttc gatgattatg ccataggctg gttccgccag      180

gccccaggga aggagcagga aagagtctca tgtatgagta gtagtgatgg tagcacatac      240

tatgcagact ccgtgaaggg ccgattcacc atctccagtg acaacgccaa gaacacggtg      300

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg tgccgcaggg      360

gtcaattact atcgcgagga tgggtgcccg ggcgcgttgg actactgggg ccaggggacc      420

caggtcaccg tctcctcaac cacgacgcca gcgccgcgac caccaacacc ggcgcccacc      480

atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc ggccagcggc ggggggcgca      540

gtgcacacga gggggctgga cttcgcctgt gatatctaca tctgggcgcc cttggccggg      600

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaaacg gggcagaaag      660

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa      720

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag      780

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag      840

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct      900

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag      960

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1020

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1080

cttcacatgc aggccctgcc ccctcgc                                         1107


<210>  75
<211>  1089
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-1F

<400>  75
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc aggtggtgga gtcgggggga ggaatggtgc aggctggggg atctctgagg      120

ctctcctgtg cagcctctgg aaagcgcttc agtttctatt ttatgggatg gtaccgccag      180

gctccaggaa agcagcgcga gttggtcgcc cttattactg gtgatggcag gacaaactat      240

gcagggtccg tggagggccg attcaccatc tccagagaca acgccaagaa cacgctatat      300

ctgcaaatga acagcatgaa acctgaggac acagccgtct attattgcta tgcagatgca      360

ttcgcggggg ccggccgcga tgagtactgg ggccagggga cccaggtcag cgtctcctca      420

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      480

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      540

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      600

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc      660

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga      720

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac      780

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      840

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      900

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      960

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1020

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1080

ccccctcgc                                                             1089


<210>  76
<211>  1086
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-1G

<400>  76
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcagttgc agctcgtgga gtccggggga ggcttggtgc aacttggggg gtctctgacg      120

ctctcctgta cagcctctgg gattatcttc aatagcgatt acgtgggctg gtaccgccag      180

gctccagggt cggatcgcga gttggtcgca cttactagta atatgaggac aaactatgca      240

gactccgtgg agggccgatt caccatctcc agagacaacg ccaagaatac ggtgtatctg      300

caaatgaaca gcctgaaacc tgaggacacg gccgtctatt attgtaatgt aaatagaatg      360

acctcctatg ggcctcggga ctactggggc caggggaccc aggtcaccgt ctcctccacc      420

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc      480

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac      540

ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg      600

tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa      660

caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt      720

ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc      780

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag      840

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga      900

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc      960

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     1020

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     1080

cctcgc                                                                1086


<210>  77
<211>  1089
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-1H

<400>  77
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggtgga ggaatggtgc aggctggggg atctctgaga      120

ctctcctgtg ctgcctctgg aaagcccttc agtttctatt tcatgggatg gtaccgccag      180

gctccaggaa agcagcgcga gttggtcgcc cttattaccg gtgatggtat gacaaactat      240

gcagactccg tggagggccg attcaccatc tccagagaca acgccaagaa cacaatgtat      300

ctgcaaatga acagcctgaa acctgaggac acagccgtct attattgcta tgcagatgta      360

tgggcggggg ccggccgcga tgagtactgg ggccagggga cccgggtcac cgtctcctca      420

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      480

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      540

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      600

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc      660

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga      720

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac      780

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      840

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      900

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      960

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1020

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1080

ccccctcgc                                                             1089


<210>  78
<211>  1083
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-3H

<400>  78
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcagttgc agctcgtgga gtcgggtgga ggcttggtgc agcctggggg gtctctgaga      120

ctctcctgtg cagcctctgg aaacatcctc agattcaatg ccgtgggctg gtaccgccag      180

gctccaggga agcagcgcga cttggtcgcg gctatggctg gtgcacggac aaactatgca      240

gactccgtgg agggccgatt caccatctcc ggaaacaacg ccaacaacac ggtttatctg      300

caaatgaaca gcctgaaacc tgaagacaca ggcgtctact actgtggtgc tgaccgcgta      360

tatggtccgc cgtatgaata tgggggccgg gggacccagg tcaccgtctt gtcaaccacg      420

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      480

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      540

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      600

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa      660

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca      720

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc      780

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag      840

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg      900

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac      960

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1020

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1080

cgc                                                                   1083


<210>  79
<211>  1068
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-5A

<400>  79
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtcgggggga ggcttggtgc aggctggggg gtctctgagg      120

ctctcctgtg cagcctctga aagcatcttc aataattatg tcatggcctg gtaccgccag      180

cctccaggga agcagcgcga ggcggtcgca caaattagta ctgatggtag tgcgtactat      240

caggaccgag tgaagggccg attcactatc tccagagaca acgccaagaa cttggtgaat      300

ctgcaaatga gcagcctgaa acctgaggac acagccgtct attactgtac tgcaggtctc      360

cagtactggg gccaggggac ccaggtcacc gtctcctcaa ccacgacgcc agcgccgcga      420

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc      480

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac      540

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt      600

tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca      660

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga      720

ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta caagcagggc      780

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac      840

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa      900

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg      960

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     1020

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgc                  1068


<210>  80
<211>  1110
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-5B

<400>  80
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggtgc agctcgtgga gtctggagga ggcttggtgc aggctggggg gtctctgaga      120

ctctcctgtg cagcctctgg attcactttc gatgattatg ccataggctg gttccgccag      180

gccccaggga aggagcctga gggggtctca tgtttcagga gtagtgatgg taacatatac      240

tattcagact ccgtgagggg ccgattcacc atctccagtg acaacgccaa gaacacggtg      300

tatctgcaaa tgaacagact gaaacctgag gacacggccg tttactactg tgcagcctat      360

agcgtactgc tcaggccctg ggtgttatgt gaaggctcat atgactactg gggccagggg      420

acccaggtca ccgtctcctc aaccacgacg ccagcgccgc gaccaccaac accggcgccc      480

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      540

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      600

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga      660

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag      720

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg      780

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac      840

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac      900

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg      960

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1020

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1080

gcccttcaca tgcaggccct gccccctcgc                                      1110


<210>  81
<211>  1089
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-5H

<400>  81
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtcaggggga ggtatggtgc aggctggggg atctctgaga      120

ctctcctgtg cagcccctgg aaagatcttc agtttctatt tcatgggatg gtaccgccag      180

gctccaggaa agcagcgcga gttggtcgcc cttattaccg gtgatggtag gacaaactat      240

gcagactccg tggagggccg attcaccatc tccagagaca acgccaagaa cacggtgtat      300

ctgcaaatga acagcctgaa acctgaggac acagccgtct attattgcta tgcagatgta      360

tttgcgaggg ccggccgcga tgagtactgg ggccagggga cccaggtcag cgtctcctca      420

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      480

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      540

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      600

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc      660

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga      720

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac      780

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      840

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      900

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      960

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1020

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1080

ccccctcgc                                                             1089


<210>  82
<211>  1107
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-7D

<400>  82
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcttggtgc aggctggggg gtctctgaga      120

ctctcctgtg cagcctctgg attcactttc gatgattatg ccataggctg gttccgccag      180

gccccaggga aggagcaaga gggggtctca tgtattagac gtagtgatgg tagcacatgg      240

tatgcaaact ccgtgaaggg ccgattcacc atctccaatg acaacgccaa gaacacggtg      300

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg cgcagtagat      360

cgttacggtc agagttggca cgagggccgc ggcgctttgg acgcatgggg ccaggggacc      420

ctggtcactg tctcctcaac cacgacgcca gcgccgcgac caccaacacc ggcgcccacc      480

atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc ggccagcggc ggggggcgca      540

gtgcacacga gggggctgga cttcgcctgt gatatctaca tctgggcgcc cttggccggg      600

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaaacg gggcagaaag      660

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa      720

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag      780

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag      840

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct      900

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag      960

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1020

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1080

cttcacatgc aggccctgcc ccctcgc                                         1107


<210>  83
<211>  1089
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-H3

<400>  83
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggtgc agctcgtgga gtctggggga ggaatggtgc aggctgggcg atctctgaga      120

ctctcctgtg ctgcctctgg aaagcccttc agtttctatt tcatgggatg gtatcgccag      180

gctccaggaa aggagcgcga gttggtcgcc cttattaccg gtgatggtat gacaaactat      240

gcagactccg tggagggccg attcaccatc tccagagaca acgccaagaa tacattgtat      300

ctcgaaatga acagcctgaa acctgaggac acagccgtct attattgcta tgcagatgct      360

tgggcggggg ccgttcgcgc cgagtactgg ggccagggga cccaggtcag cgtctcctca      420

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      480

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      540

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      600

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc      660

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga      720

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac      780

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      840

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      900

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      960

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1020

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1080

ccccctcgc                                                             1089


<210>  84
<211>  1107
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-L2

<400>  84
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtccggggga ggcttggtgc aggctggggg gtctctgaga      120

ctctcctgtg cagcctctgg attcactgtc gatgattatg tcataggctg gttccgccag      180

gccccaggga aggagcatga gggggtctca tgtattagta gtaatgatgg tagtacatgg      240

tatgcagact ccgtgaaggg ccgattcacc atctccagtg acaacgccaa gaacacgatg      300

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg tgcagctaaa      360

tacgcaccct acgggttgga gtactgggag ggaggcatgg actactgggg caaagggacc      420

ctggtcaccg tctcctcaac cacgacgcca gcgccgcgac caccaacacc ggcgcccacc      480

atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc ggccagcggc ggggggcgca      540

gtgcacacga gggggctgga cttcgcctgt gatatctaca tctgggcgcc cttggccggg      600

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaaacg gggcagaaag      660

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa      720

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag      780

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag      840

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct      900

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag      960

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1020

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1080

cttcacatgc aggccctgcc ccctcgc                                         1107


<210>  85
<211>  1104
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-L1

<400>  85
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc aggtggtgga gtctggggga ggattggtgc aggctggggg ctctctgaga      120

ctctcctgtg cagcctctgg acgcaccttc agttcatatg ccatgggctg ggtccgccag      180

gctccaggga aggaccaaga gtttgtagcg gctattaact ggagtgatgg tagcacatac      240

tatgcagact ccgtgaaggg ccgattcacc atcgccagag acaacgccaa gaacacggcg      300

tttctgcaaa tgaacagcct gaaacctgag gacacggccg tgtattactg tgcagcaggg      360

tgttgcggag tagctgatgc ccccctcaat gctttggacg catggggcca ggggaccctg      420

gtcactgtct cctcaaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      480

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      540

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      600

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa      660

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat      720

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc      780

agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc      840

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag      900

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa      960

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1020

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1080

cacatgcagg ccctgccccc tcgc                                            1104


<210>  86
<211>  21
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Lenti-For

<400>  86
tcaagcctca gacagtggtt c                                                 21


<210>  87
<211>  24
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Lenti-Rev

<400>  87
cctcataaag agacagcaac cagg                                              24


<210>  88
<211>  63
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD8ź

<400>  88
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  89
<211>  135
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD8Ľ

<400>  89
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  90
<211>  75
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD8ĿĤṹ

<400>  90
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gcaaa                                                        75


<210>  91
<211>  120
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  4-1BBĹ̼źŴṹ

<400>  91
cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact       60

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa      120


<210>  92
<211>  339
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD3zetaİźŴṹ

<400>  92
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag       60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      120

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac      180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      300

acctacgacg cccttcacat gcaggccctg ccccctcgc                             339


<210>  93
<211>  1518
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD70-CAR-03

<400>  93
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggcggca gcgactacaa agacgatgac gacaagggtg gctcccaggc agtggtgacc      120

caggagcctt ccctgacagt gtctccagga gggacggtca cgctcacctg cggcctcaaa      180

tctgggtctg tcacttccga taacttcccc acttggtacc agcagacacc aggccaggct      240

ccccgattgc ttatctacaa cacaaacacc cgtcactctg gcgtccccga ccgcttctcc      300

ggatccatcc tgggcaacaa agccgccctc accatcacgg gggcccaggc cgacgacgag      360

gccgaatatt tctgtgctct gttcataagt aatcctagtg ttgagttcgg cggagggacc      420

caactgaccg tcctaggtgg tggcggtggc tcgggcggtg gtgggtcggg tggcggcgga      480

tctgaggtgc agctcgtgga gtctggggga ggcttggtgc agcctggggg gtctctgaga      540

ctctcctgtg cagcctctgg attcaccttc agtgtctact acatgaactg ggtccgccag      600

gctccaggga aggggctcga gtgggtctca gatattaata atgaaggtgg tactacatac      660

tatgcagact ccgtgaaggg ccgattcacc atctccagag acaactctaa gaacagcctg      720

tatctgcaaa tgaacagcct gcgcgccgag gacacggccg tgtactactg cgcgagagat      780

gccggatata gcaaccatgt acccatcttt gattcttggg gccaggggac cctggtcact      840

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      900

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      960

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg     1020

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1080

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1140

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1200

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1260

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1320

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1380

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1440

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1500

caggccctgc cccctcgc                                                   1518


<210>  94
<211>  232
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Fc

<400>  94

Glu Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         




