                         SEQUENCE LISTING

<110>  ZYMEWORKS INC.
 
<120>  HETERODIMERIC IGA FC CONSTRUCTS AND METHODS OF USE THEREOF

<130>  V817562WO

<140>  PCT/CA2021/051732
<141>  2021-12-03

<150>  63/194,828
<151>  2021-05-28

<150>  63/121,180
<151>  2020-12-03

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 11150 Trastuzumab VL  IgKCL

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  2
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21715 IgA2 hinge - IgA2m1 CH2 - IgA2m1 CH3

<400>  2

Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His 
1               5                   10                  15      


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
            20                  25                  30          


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp 
        35                  40                  45              


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
    50                  55                  60                  


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln 
65                  70                  75                  80  


Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu 
                85                  90                  95      


Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
            100                 105                 110         


Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu 
        115                 120                 125             


Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys 
    130                 135                 140                 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
145                 150                 155                 160 


Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
                165                 170                 175     


Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys 
            180                 185                 190         


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
        195                 200                 205             


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
    210                 215                 220 


<210>  3
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 21755 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  4
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23767 IgA2 hinge - IgA2m1 CH2 - IgA2m1 CH3

<400>  4

Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His 
1               5                   10                  15      


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
            20                  25                  30          


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp 
        35                  40                  45              


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
    50                  55                  60                  


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln 
65                  70                  75                  80  


Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu 
                85                  90                  95      


Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
            100                 105                 110         


Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu 
        115                 120                 125             


Asn Glu Leu Val Arg Leu Thr Cys Arg Ala Arg Gly Phe Ser Pro Lys 
    130                 135                 140                 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
145                 150                 155                 160 


Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
                165                 170                 175     


Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys 
            180                 185                 190         


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
        195                 200                 205             


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
    210                 215                 220 


<210>  5
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23768 IgA2 hinge - IgA2m1 CH2 - IgA2m1 CH3

<400>  5

Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His 
1               5                   10                  15      


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
            20                  25                  30          


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp 
        35                  40                  45              


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
    50                  55                  60                  


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln 
65                  70                  75                  80  


Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu 
                85                  90                  95      


Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
            100                 105                 110         


Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu 
        115                 120                 125             


Asn Glu Leu Val Arg Leu Thr Cys Lys Ala Arg Gly Phe Ser Pro Lys 
    130                 135                 140                 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
145                 150                 155                 160 


Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
                165                 170                 175     


Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys 
            180                 185                 190         


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
        195                 200                 205             


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
    210                 215                 220 


<210>  6
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23769 IgA2 hinge - IgA2m1 CH2 - IgA2m1 CH3

<400>  6

Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His 
1               5                   10                  15      


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
            20                  25                  30          


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp 
        35                  40                  45              


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
    50                  55                  60                  


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln 
65                  70                  75                  80  


Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu 
                85                  90                  95      


Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
            100                 105                 110         


Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu 
        115                 120                 125             


Asn Glu Leu Val Arg Leu Thr Cys Lys Ala Arg Gly Phe Ser Pro Lys 
    130                 135                 140                 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
145                 150                 155                 160 


Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
                165                 170                 175     


Thr Phe Ala Val Thr Ser Arg Leu Arg Val Ala Ala Glu Asp Trp Lys 
            180                 185                 190         


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
        195                 200                 205             


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
    210                 215                 220 


<210>  7
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23770 IgA2 hinge - IgA2m1 CH2 - IgA2m1 CH3

<400>  7

Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His 
1               5                   10                  15      


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
            20                  25                  30          


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp 
        35                  40                  45              


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
    50                  55                  60                  


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln 
65                  70                  75                  80  


Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu 
                85                  90                  95      


Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
            100                 105                 110         


Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu 
        115                 120                 125             


Asn Glu Leu Val Lys Leu Thr Cys Lys Ala Lys Gly Phe Ser Pro Lys 
    130                 135                 140                 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
145                 150                 155                 160 


Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
                165                 170                 175     


Thr Phe Ala Val Thr Ser Arg Leu Arg Val Ala Ala Glu Asp Trp Lys 
            180                 185                 190         


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
        195                 200                 205             


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
    210                 215                 220 


<210>  8
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23771 IgA2 hinge - IgA2m1 CH2 - IgA2m1 CH3

<400>  8

Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His 
1               5                   10                  15      


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
            20                  25                  30          


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp 
        35                  40                  45              


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
    50                  55                  60                  


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln 
65                  70                  75                  80  


Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu 
                85                  90                  95      


Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
            100                 105                 110         


Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu 
        115                 120                 125             


Asn Glu Leu Val Thr Leu Thr Cys Lys Ala Lys Gly Phe Ser Pro Lys 
    130                 135                 140                 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
145                 150                 155                 160 


Lys Tyr Leu Thr Trp Ala Ser Arg Gln Arg Pro Ser Gln Gly Thr Thr 
                165                 170                 175     


Thr Phe Ala Val Thr Ser Lys Leu Arg Val Ala Ala Glu Asp Trp Lys 
            180                 185                 190         


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
        195                 200                 205             


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
    210                 215                 220 


<210>  9
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23772 IgA2 hinge - IgA2m1 CH2 - IgA2m1 CH3

<400>  9

Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His 
1               5                   10                  15      


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
            20                  25                  30          


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp 
        35                  40                  45              


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
    50                  55                  60                  


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln 
65                  70                  75                  80  


Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu 
                85                  90                  95      


Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
            100                 105                 110         


Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu 
        115                 120                 125             


Asn Glu Leu Val Thr Leu Thr Cys Lys Ala Lys Gly Phe Ser Pro Lys 
    130                 135                 140                 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
145                 150                 155                 160 


Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
                165                 170                 175     


Thr Phe Ala Val Thr Ser Lys Leu Arg Val Ala Ala Glu Asp Trp Lys 
            180                 185                 190         


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
        195                 200                 205             


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
    210                 215                 220 


<210>  10
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23773 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Asp Leu Thr Cys Asp Ala Asp Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Ala Val Thr Ser Glu Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  11
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23774 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Glu Leu Thr Cys Glu Ala Asp Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Ala Val Thr Ser Asp Leu Glu Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  12
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23775 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Glu Leu Thr Cys Leu Ala Asp Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Ala Val Thr Ser Asp Leu Asp Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  13
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23776 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Glu Leu Thr Cys Leu Ala Asp Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Ala Val Thr Ser Glu Leu Glu Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  14
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23777 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Thr Leu Thr Cys Leu Ala Asp Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Asp Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Ala Val Thr Ser Asp Leu Glu Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  15
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23778 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Tyr Val Leu Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  16
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23779 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Tyr Val Tyr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  17
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23780 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Phe Val Tyr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  18
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23781 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Thr Leu Thr Cys Met Ala Arg Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Phe Val Trp Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  19
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23782 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Tyr Val Met Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  20
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23783 IgA2 hinge - IgA2m1 CH2 - IgA2m1 CH3

<400>  20

Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His 
1               5                   10                  15      


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
            20                  25                  30          


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp 
        35                  40                  45              


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
    50                  55                  60                  


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln 
65                  70                  75                  80  


Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu 
                85                  90                  95      


Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
            100                 105                 110         


Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu 
        115                 120                 125             


Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys 
    130                 135                 140                 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
145                 150                 155                 160 


Lys Tyr Thr Thr Leu Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
                165                 170                 175     


Thr Phe Ala Val Thr Ser Leu Leu Arg Val Ala Ala Glu Asp Trp Lys 
            180                 185                 190         


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
        195                 200                 205             


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
    210                 215                 220 


<210>  21
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23784 IgA2 hinge - IgA2m1 CH2 - IgA2m1 CH3

<400>  21

Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His 
1               5                   10                  15      


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
            20                  25                  30          


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp 
        35                  40                  45              


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
    50                  55                  60                  


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln 
65                  70                  75                  80  


Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu 
                85                  90                  95      


Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
            100                 105                 110         


Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu 
        115                 120                 125             


Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys 
    130                 135                 140                 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
145                 150                 155                 160 


Lys Tyr Val Thr Leu Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
                165                 170                 175     


Thr Phe Ala Val Thr Ser Leu Leu Arg Val Ala Ala Glu Asp Trp Lys 
            180                 185                 190         


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
        195                 200                 205             


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
    210                 215                 220 


<210>  22
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23785 IgA2 hinge - IgA2m1 CH2 - IgA2m1 CH3

<400>  22

Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His 
1               5                   10                  15      


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
            20                  25                  30          


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp 
        35                  40                  45              


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
    50                  55                  60                  


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln 
65                  70                  75                  80  


Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu 
                85                  90                  95      


Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
            100                 105                 110         


Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu 
        115                 120                 125             


Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys 
    130                 135                 140                 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
145                 150                 155                 160 


Lys Tyr Leu Thr Leu Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
                165                 170                 175     


Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys 
            180                 185                 190         


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
        195                 200                 205             


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
    210                 215                 220 


<210>  23
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 23786 IgA2 hinge - IgA2m1 CH2 - IgA2m1 CH3

<400>  23

Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His 
1               5                   10                  15      


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
            20                  25                  30          


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp 
        35                  40                  45              


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
    50                  55                  60                  


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln 
65                  70                  75                  80  


Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu 
                85                  90                  95      


Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
            100                 105                 110         


Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu 
        115                 120                 125             


Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys 
    130                 135                 140                 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
145                 150                 155                 160 


Lys Tyr Val Thr Thr Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
                165                 170                 175     


Thr Phe Ala Val Thr Ser Leu Leu Arg Val Ala Ala Glu Asp Trp Lys 
            180                 185                 190         


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
        195                 200                 205             


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
    210                 215                 220 


<210>  24
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 24674 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Thr Leu Val Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Phe Val Tyr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  25
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 24675 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Thr Leu Leu Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Phe Val Tyr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  26
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 24676 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Thr Leu Ile Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Phe Val Tyr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  27
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 24677 IgA2 hinge - IgA2m1 CH2 - IgA2m1 CH3

<400>  27

Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His 
1               5                   10                  15      


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
            20                  25                  30          


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp 
        35                  40                  45              


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
    50                  55                  60                  


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln 
65                  70                  75                  80  


Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu 
                85                  90                  95      


Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
            100                 105                 110         


Arg Pro Glu Val His Leu Phe Pro Pro Pro Ser Glu Glu Leu Ala Leu 
        115                 120                 125             


Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys 
    130                 135                 140                 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
145                 150                 155                 160 


Lys Tyr Val Thr Thr Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
                165                 170                 175     


Thr Phe Ala Val Thr Ser Leu Leu Arg Val Ala Ala Glu Asp Trp Lys 
            180                 185                 190         


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
        195                 200                 205             


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
    210                 215                 220 


<210>  28
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 24678 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val Tyr Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Phe Val Tyr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  29
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 24679 IgA2 hinge - IgA2m1 CH2 - IgA2m1 CH3

<400>  29

Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His 
1               5                   10                  15      


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
            20                  25                  30          


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp 
        35                  40                  45              


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
    50                  55                  60                  


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln 
65                  70                  75                  80  


Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu 
                85                  90                  95      


Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
            100                 105                 110         


Arg Pro Glu Val Tyr Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu 
        115                 120                 125             


Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys 
    130                 135                 140                 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
145                 150                 155                 160 


Lys Tyr Val Thr Thr Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
                165                 170                 175     


Thr Phe Ala Val Thr Ser Leu Leu Arg Val Ala Ala Glu Asp Trp Lys 
            180                 185                 190         


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
        195                 200                 205             


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
    210                 215                 220 


<210>  30
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 25880 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val Cys Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Phe Val Tyr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  31
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 25881 IgA2 hinge - IgA2m1 CH2 - IgA2m1 CH3

<400>  31

Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His 
1               5                   10                  15      


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
            20                  25                  30          


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp 
        35                  40                  45              


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
    50                  55                  60                  


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln 
65                  70                  75                  80  


Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu 
                85                  90                  95      


Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
            100                 105                 110         


Arg Pro Glu Val His Leu Leu Pro Pro Cys Ser Glu Glu Leu Ala Leu 
        115                 120                 125             


Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys 
    130                 135                 140                 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
145                 150                 155                 160 


Lys Tyr Val Thr Thr Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
                165                 170                 175     


Thr Phe Ala Val Thr Ser Leu Leu Arg Val Ala Ala Glu Asp Trp Lys 
            180                 185                 190         


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
        195                 200                 205             


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
    210                 215                 220 


<210>  32
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 25882 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val His Leu Leu Pro Pro Cys Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Phe Val Tyr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  33
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 25883 IgA2 hinge - IgA2m1 CH2 - IgA2m1 CH3

<400>  33

Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His 
1               5                   10                  15      


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
            20                  25                  30          


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp 
        35                  40                  45              


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
    50                  55                  60                  


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln 
65                  70                  75                  80  


Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu 
                85                  90                  95      


Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
            100                 105                 110         


Arg Pro Glu Val Cys Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu 
        115                 120                 125             


Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys 
    130                 135                 140                 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
145                 150                 155                 160 


Lys Tyr Val Thr Thr Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
                165                 170                 175     


Thr Phe Ala Val Thr Ser Leu Leu Arg Val Ala Ala Glu Asp Trp Lys 
            180                 185                 190         


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
        195                 200                 205             


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
    210                 215                 220 


<210>  34
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 25884 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val Cys Leu Leu Pro Pro Cys Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Phe Val Tyr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  35
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 25885 IgA2 hinge - IgA2m1 CH2 - IgA2m1 CH3

<400>  35

Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His 
1               5                   10                  15      


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
            20                  25                  30          


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp 
        35                  40                  45              


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
    50                  55                  60                  


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln 
65                  70                  75                  80  


Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu 
                85                  90                  95      


Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
            100                 105                 110         


Arg Pro Glu Val Cys Leu Leu Pro Pro Cys Ser Glu Glu Leu Ala Leu 
        115                 120                 125             


Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys 
    130                 135                 140                 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
145                 150                 155                 160 


Lys Tyr Val Thr Thr Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
                165                 170                 175     


Thr Phe Ala Val Thr Ser Leu Leu Arg Val Ala Ala Glu Asp Trp Lys 
            180                 185                 190         


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
        195                 200                 205             


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
    210                 215                 220 


<210>  36
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 25886 Trastuzumab VH - IgG1 CH1 - IgG1/IgA2 hinge - 
       IgA2m1 CH2 - IgA2m1 CH3

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                245                 250                 255     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            260                 265                 270         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln Pro 
    290                 295                 300                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
305                 310                 315                 320 


Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg 
                325                 330                 335     


Pro Glu Val Cys Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp 
        355                 360                 365             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    370                 375                 380                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
385                 390                 395                 400 


Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                405                 410                 415     


Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
        435                 440             


<210>  37
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone ID 25887 IgA2 hinge - IgA2m1 CH2 - IgA2m1 CH3

<400>  37

Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His 
1               5                   10                  15      


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr 
            20                  25                  30          


Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp 
        35                  40                  45              


Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp 
    50                  55                  60                  


Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Ser Ala Gln 
65                  70                  75                  80  


Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu 
                85                  90                  95      


Leu Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe 
            100                 105                 110         


Arg Pro Glu Val His Leu Leu Pro Pro Cys Ser Glu Glu Leu Ala Leu 
        115                 120                 125             


Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys 
    130                 135                 140                 


Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu 
145                 150                 155                 160 


Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
                165                 170                 175     


Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys 
            180                 185                 190         


Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu 
        195                 200                 205             


Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
    210                 215                 220 


<210>  38
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Her2 Fab HC

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215             


<210>  39
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Her2 Fab LC

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 upper hinge

<400>  40

Glu Pro Lys Ser Cys 
1               5   


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA2 hinge

<400>  41

Arg Val Pro Pro Pro Pro Pro 
1               5           


<210>  42
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA2m1 wild type

<400>  42

Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu 
1               5                   10                  15      


Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg 
            20                  25                  30          


Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser 
        35                  40                  45              


Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val 
    50                  55                  60                  


Ser Ser Val Leu Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Thr Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala 
                85                  90                  95      


Asn Ile Thr Lys Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu 
            100                 105                 110         


Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr 
        115                 120                 125             


Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu 
    130                 135                 140                 


Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser 
145                 150                 155                 160 


Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile 
                165                 170                 175     


Leu Arg Val Ala Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys 
            180                 185                 190         


Met Val Gly His Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile 
        195                 200                 205             


Asp Arg Leu Ala Gly 
    210             


<210>  43
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified IgA2m1

<400>  43

Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu 
1               5                   10                  15      


Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg 
            20                  25                  30          


Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser 
        35                  40                  45              


Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val 
    50                  55                  60                  


Ser Ser Val Leu Pro Gly Ser Ala Gln Pro Trp Asn His Gly Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Thr Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala 
                85                  90                  95      


Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu 
            100                 105                 110         


Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr 
        115                 120                 125             


Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu 
    130                 135                 140                 


Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser 
145                 150                 155                 160 


Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile 
                165                 170                 175     


Leu Arg Val Ala Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys 
            180                 185                 190         


Met Val Gly His Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile 
        195                 200                 205             


Asp Arg Leu Ala Gly 
    210             


<210>  44
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA1 wild type

<400>  44

Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu 
1               5                   10                  15      


Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg 
            20                  25                  30          


Asp Ala Ser Gly Val Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser 
        35                  40                  45              


Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val 
    50                  55                  60                  


Ser Ser Val Leu Pro Gly Cys Ala Glu Pro Trp Asn His Gly Lys Thr 
65                  70                  75                  80  


Phe Thr Cys Thr Ala Ala Tyr Pro Glu Ser Lys Thr Pro Leu Thr Ala 
                85                  90                  95      


Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu 
            100                 105                 110         


Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr 
        115                 120                 125             


Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu 
    130                 135                 140                 


Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser 
145                 150                 155                 160 


Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile 
                165                 170                 175     


Leu Arg Val Ala Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys 
            180                 185                 190         


Met Val Gly His Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile 
        195                 200                 205             


Asp Arg Leu Ala Gly 
    210             


<210>  45
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA2m2 wild type

<400>  45

Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu 
1               5                   10                  15      


Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg 
            20                  25                  30          


Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser 
        35                  40                  45              


Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val 
    50                  55                  60                  


Ser Ser Val Leu Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Thr Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala 
                85                  90                  95      


Asn Ile Thr Lys Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu 
            100                 105                 110         


Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr 
        115                 120                 125             


Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu 
    130                 135                 140                 


Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser 
145                 150                 155                 160 


Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr Tyr Ala Val Thr Ser Ile 
                165                 170                 175     


Leu Arg Val Ala Ala Glu Asp Trp Lys Lys Gly Glu Thr Phe Ser Cys 
            180                 185                 190         


Met Val Gly His Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile 
        195                 200                 205             


Asp Arg Leu Ala Gly 
    210             


<210>  46
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-tailpiece IgA1/IgA2m1

<400>  46

Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly 
1               5                   10                  15      


Thr Cys Tyr 
            


<210>  47
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-tailpiece IgA2m2

<400>  47

Lys Pro Thr His Ile Asn Val Ser Val Val Met Ala Glu Ala Asp Gly 
1               5                   10                  15      


Thr Cys Tyr 
            


<210>  48
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J Chain

<400>  48

Glu Phe Ala Thr Met Arg Pro Thr Trp Ala Trp Trp Leu Phe Leu Val 
1               5                   10                  15      


Leu Leu Leu Ala Leu Trp Ala Pro Ala Arg Gly Gln Glu Asp Glu Arg 
            20                  25                  30          


Ile Val Leu Val Asp Asn Lys Cys Lys Cys Ala Arg Ile Thr Ser Arg 
        35                  40                  45              


Ile Ile Arg Ser Ser Glu Asp Pro Asn Glu Asp Ile Val Glu Arg Asn 
    50                  55                  60                  


Ile Arg Ile Ile Val Pro Leu Asn Asn Arg Glu Asn Ile Ser Asp Pro 
65                  70                  75                  80  


Thr Ser Pro Leu Arg Thr Arg Phe Val Tyr His Leu Ser Asp Leu Cys 
                85                  90                  95      


Lys Lys Cys Asp Pro Thr Glu Val Glu Leu Asp Asn Gln Ile Val Thr 
            100                 105                 110         


Ala Thr Gln Ser Asn Ile Cys Asp Glu Asp Ser Ala Thr Glu Thr Cys 
        115                 120                 125             


Tyr Thr Tyr Asp Arg Asn Lys Cys Tyr Thr Ala Val Val Pro Leu Val 
    130                 135                 140                 


Tyr Gly Gly Glu Thr Lys Met Val Glu Thr Ala Leu Thr Pro Asp Ala 
145                 150                 155                 160 


Cys Tyr Pro Asp 
                


<210>  49
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  49

Glu Phe Ala Thr Met Arg Pro Thr Trp Ala Trp Trp Leu Phe Leu Val 
1               5                   10                  15      


Leu Leu Leu Ala Leu Trp Ala Pro Ala Arg Gly 
            20                  25          


