                               SEQUENCE LISTING

<110> ESPEROVAX INC.
 
<120> YEAST-BASED EXPRESSION OF THERAPEUTIC PROTEINS IN VIVO

<130> ESP-002-PCT

<140> PCT/US2021/060865
<141> 2021-11-24

<150> 63/118,610
<151> 2020-11-25

<160> 33    

<170> PatentIn version 3.5

<210> 1
<211> 1821
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
gaattcatga gatttccttc aatttttact gcagttttat tcgcagcatc ctccgcatta       60

gctgctccag tcaacactac aacagaagat gaaacggcac aaattccggc tgaagctgtc      120

atcggttact cagatttaga aggggatttc gatgttgctg ttttgccatt ttccaacagc      180

acaaataacg ggttattgtt tataaatact actattgcca gcattgctgc taaagaagaa      240

ggggtaagct tggagaaacg cgccccagct tctgctgttc cagctaccat tccattgacc      300

atcaccaacg actctggcag aggtccaatc tacctgtacg ttttgggtga gagagatggc      360

gttgctggtt gggctgatgc tggtggtact tttcatccat ggccaggtgg tgtgggtcca      420

gttccagttc ctgctccaga cgcatctatt gctggtccag gtccaggaca gtctgttacc      480

attagactgc caaagctgtc gggcagagtg tactactctt acggtcagaa gatgaccttc      540

cagatcgtgc tggacggaag attggttcag ccagctgttc agaacgactc ggacccaaac      600

agaaacatcc tgttcaactg gaccgagtac accttgaacg atggtggtct gtggatcaac      660

tctacccaag ttgaccattg gtctgcccca taccaggttg gtgttcaacg cgctgatggt      720

caggttttgt ctaccggtat gctgaagcca aacggttacg aggctttcta caccgctttg      780

gaatctgctg gatggggtgg tttggttcaa agagcaccag acggttctag actgagagca      840

ttgaacccat ctcacggtat cgacgtgggc aagatttctt ctgcctcgat cgactcttac      900

gtgaccgagg tttggaactc gtacagaacc agagacatgt gcgtgacccc attttctcac      960

gagccaggta ctcagttcag aggtagagtg gatggtgact ggttcagatt cagaaacggc     1020

tctggtcaag aggttgccgc ttttaagaaa ccagacgcct cttctgtgta cggctgtcac     1080

aaagatcttc aggctccaaa cgaccacgtt gtgggaccaa ttgctagaac cttgtgtgcc     1140

gctctggtta gaaccactgc tctgactaac ccaaaccagc cagatgctaa ctctgccggt     1200

ttttaccagg acgccagaac taacgtttac gccaaattgg ctcaccagca gatggccaac     1260

ggtaaggctt acgcttttgc tttcgacgac gttggtgctc acgagtcttt ggttcatgac     1320

ggtaatccac aggccgccta cattaagttg gacccattca ctggtactgc taccccaatt     1380

gcaaacggtg gttctactga gcaacctgga actccaggtg gtttgccagc tggtactggt     1440

gctttgagaa ttggttctac cctgtgtctg gacgttccat gggctgatcc aactgacact     1500

aaccaggttc agctggctac ctgttctggt aacgctgctc aacaatggac cagaggtact     1560

gacggtactg ttagagccct gggaaagtgt ttggacgtgg ctagatctgg aactgctgat     1620

ggtacagccg tgtggatcta cacctgtaat ggaactggtg ctcagaagtg gacctacgac     1680

tctgctacta aggctctgag aaacccacag tctggtaagt gcttggatgc tcaaggtggt     1740

gctccattga gagatggtca gaaagttcag ctgtggacct gcaaccagac tgaggctcaa     1800

agatggaccc tgtaaggatc c                                               1821


<210> 2
<211> 1476
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
caattgatga gatttccttc aatttttact gcagttttat tcgcagcatc ctccgcatta       60

gctgctccag tcaacactac aacagaagat gaaacggcac aaattccggc tgaagctgtc      120

atcggttact cagatttaga aggggatttc gatgttgctg ttttgccatt ttccaacagc      180

acaaataacg ggttattgtt tataaatact actattgcca gcattgctgc taaagaagaa      240

ggggtaagct tggagaaacg caccccagtg tctaccaacg acgtgtcggt tgagaaaaga      300

gcctctggtt acaccaacgc cgtgtacttt acaaactggg gcatctacgg cagaaacttc      360

cagccacaag acttggttgc ctctgacatc acccacgtga tctacccatt catgaacttc      420

caggctgacg gaaccgttgt ttctggtgat gcttacgctg actaccagaa gcactactcg      480

gacgactctt ggaacgacgt tggtaacaac gcctacggtt gtgtgaacca gctgttcaag      540

ctgaagaagg ccaacagaaa cctgaaggtg atgctgtcta ttggcggttg gacttggtcg      600

actaacttcc catctgctgc ttctaccgac gctaacagaa agaacttcgc caagaccgcc      660

atcacgttca tgaaggattg gggtttcgac ggtatcgacg ttgactggga atacccagct      720

gacgatactc aggctaccaa catggttctg ctgctgaaag agatcagatc gcagttggac      780

gcttacgcag ctcaatacgc tccaggttac cacttcctgt tgtctattgc tgctcctgct      840

ggtccagagc attactctgc attgcacatg gctgaccttg gtcaggttct ggactacgtt      900

aacctgatgg cttacgacta cgctggctct tggtcgtctt actctggtca cgatgctaac      960

ctgttcgcta acccatcgaa cccaaactcg tcgccataca acactgacca ggccatcaag     1020

gcctacatca acggtggtgt tccagcctct aagatcgttc tgggtatgcc aatctacggt     1080

agatcgttcg agtccaccaa cggtattggt cagacctaca acggtatcgg ctctggttct     1140

tgggagaacg gtatttggga ctacaaggtg ttgccaaagg ctggtgctac tgtgcagtac     1200

gactctgttg ctcaggccta ctactcttac gactcgtcgt ctaaagagct gatctcgttt     1260

gacaccccag acatggtgtc gaagaaggtg tcttacctga agaaccttgg ccttggcggt     1320

tcgatgtttt gggaagcttc tgctgacaag accggctctg actctctgat tggtacttct     1380

cacagagccc tgggttcttt ggactctact cagaacttgc tgtcgtaccc taacagccag     1440

tacgacaaca tcagatcggg cctgaactaa agatct                               1476


<210> 3
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Lys Phe Ser Phe Val Tyr Gly Leu Thr Gly Phe Leu Ala Ala Thr 
1               5                   10                  15      


Ser Ser Ala Leu Pro Ser Glu Ile Leu Ser Thr Gly Tyr Glu Arg Ser 
            20                  25                  30          


Ala Leu Glu Lys Arg Gly Asp Gly Tyr Leu Ile Met Cys Lys Asn Cys 
        35                  40                  45              


Asp Pro Asn Thr Gly Ser Cys Asp Trp Lys Gln Asn Trp Asn Thr Cys 
    50                  55                  60                  


Val Gly Ile Gly Ala Asn Val His Trp Met Val Thr Gly Gly Ser Thr 
65                  70                  75                  80  


Asp Gly Lys Gln Gly Cys Ala Thr Ile Trp Glu Gly Ser Gly Cys Val 
                85                  90                  95      


Gly Arg Ser Thr Thr Met Cys Cys Pro Ala Asn Thr Cys Cys Asn Ile 
            100                 105                 110         


Asn Thr Gly Phe Tyr Ile Arg Ser Tyr Arg Arg Val Glu 
        115                 120                 125 


<210> 4
<211> 534
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
gaattcatga gatttccttc aatttttact gcagttttat tcgcagcatc ctccgcatta       60

gctgctccag tcaacactac aacagaagat gaaacggcac aaattccggc tgaagctgtc      120

atcggttact cagatttaga aggggatttc gatgttgctg ttttgccatt ttccaacagc      180

acaaataacg ggttattgtt tataaatact actattgcca gcattgctgc taaagaagaa      240

ggggtaagct tggagaaacg cggtgacggt tacctgatca tgtgcaagaa ctgtgaccca      300

aacaccggtt cttgtgactg gaagcagaac tggaacacct gtgttggtat cggtgctaac      360

gtgcactgga tggttactgg tggttctact gacggtaagc agggttgtgc taccatctgg      420

gaaggttctg gttgtgtggg aagatctacc accatgtgct gtccagctaa cacttgctgc      480

aacatcaaca ccggcttcta catcagatcg tacagaagag tcgagtaagg atcc            534


<210> 5
<211> 644
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 
            20                  25                  30          


His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 
    50                  55                  60                  


Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 
            100                 105                 110         


Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val 
        115                 120                 125             


Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 
    130                 135                 140                 


Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 
145                 150                 155                 160 


Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 
                165                 170                 175     


Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 
            180                 185                 190         


Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 
        195                 200                 205             


Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 
    210                 215                 220                 


Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr His Asn Pro Pro Ile 
                245                 250                 255     


Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 
            260                 265                 270         


Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly 
        275                 280                 285             


Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 
    290                 295                 300                 


Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr 
305                 310                 315                 320 


Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 
                325                 330                 335     


Leu Gly Pro Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 
            340                 345                 350         


Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser 
        355                 360                 365             


Gln Val Thr Asn Pro Ala Thr Ile Met Ile Gln Lys Gly Asn Phe Arg 
    370                 375                 380                 


Asn Gln Arg Lys Thr Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His 
385                 390                 395                 400 


Ile Ala Lys Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 
                405                 410                 415     


Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 
            420                 425                 430         


Phe Leu Gly Lys Ile Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe 
        435                 440                 445             


Leu Gln Ser Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 
    450                 455                 460                 


Phe Gly Glu Glu Thr Thr Thr Pro Ser Gln Lys Gln Glu Pro Ile Asp 
465                 470                 475                 480 


Lys Glu Leu Tyr Pro Leu Ala Ser Leu Arg Ser Leu Phe Gly Ser Asp 
                485                 490                 495     


Pro Ser Ser Gln Gly Gly Ser Thr Ser Ser Glu Phe Cys Ser Arg Arg 
            500                 505                 510         


Tyr Arg Gly Pro Gly Ile His Arg Pro Val Ala Thr Met Ala Ser Asn 
        515                 520                 525             


Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr Gly Asp Val Thr 
    530                 535                 540                 


Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu Trp Ile Ser Ser 
545                 550                 555                 560 


Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser Val Arg Gln Ser 
                565                 570                 575     


Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu Val Pro Lys Gly 
            580                 585                 590         


Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe Ala 
        595                 600                 605             


Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu Leu 
    610                 615                 620                 


Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly Ile 
625                 630                 635                 640 


Tyr Ala Ala Ala 
                


<210> 6
<211> 587
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
cccctctccc tccccccccc ctaacgttac tggccgaagc cgcttggaat aaggccggtg       60

tgcgtttgtc tatatgttat tttccaccat attgccgtct tttggcaatg tgagggcccg      120

gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc tcgccaaagg      180

aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt cttgaagaca      240

aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg acaggtgcct      300

ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac cccagtgcca      360

cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg tattcaacaa      420

ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg ggcctcggtg      480

cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt ctaggccccc cgaaccacgg      540

ggacgtggtt ttcctttgaa aaacacgatg ataatatggc cacaacc                    587


<210> 7
<211> 548
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Pro His Asp Arg Lys Asn Ser Ser Arg Arg Ala Trp Ala Ala Leu 
1               5                   10                  15      


Cys Ala Ala Val Leu Ala Val Ser Gly Ala Leu Val Gly Val Ala Ala 
            20                  25                  30          


Pro Ala Ser Ala Val Pro Ala Thr Ile Pro Leu Thr Ile Thr Asn Asp 
        35                  40                  45              


Ser Gly Arg Gly Pro Ile Tyr Leu Tyr Val Leu Gly Glu Arg Asp Gly 
    50                  55                  60                  


Val Ala Gly Trp Ala Asp Ala Gly Gly Thr Phe His Pro Trp Pro Gly 
65                  70                  75                  80  


Gly Val Gly Pro Val Pro Val Pro Ala Pro Asp Ala Ser Ile Ala Gly 
                85                  90                  95      


Pro Gly Pro Gly Gln Ser Val Thr Ile Arg Leu Pro Lys Leu Ser Gly 
            100                 105                 110         


Arg Val Tyr Tyr Ser Tyr Gly Gln Lys Met Thr Phe Gln Ile Val Leu 
        115                 120                 125             


Asp Gly Arg Leu Val Gln Pro Ala Val Gln Asn Asp Ser Asp Pro Asn 
    130                 135                 140                 


Arg Asn Ile Leu Phe Asn Trp Thr Glu Tyr Thr Leu Asn Asp Gly Gly 
145                 150                 155                 160 


Leu Trp Ile Asn Ser Thr Gln Val Asp His Trp Ser Ala Pro Tyr Gln 
                165                 170                 175     


Val Gly Val Gln Arg Ala Asp Gly Gln Val Leu Ser Thr Gly Met Leu 
            180                 185                 190         


Lys Pro Asn Gly Tyr Glu Ala Phe Tyr Thr Ala Leu Glu Ser Ala Gly 
        195                 200                 205             


Trp Gly Gly Leu Val Gln Arg Ala Pro Asp Gly Ser Arg Leu Arg Ala 
    210                 215                 220                 


Leu Asn Pro Ser His Gly Ile Asp Val Gly Lys Ile Ser Ser Ala Ser 
225                 230                 235                 240 


Ile Asp Ser Tyr Val Thr Glu Val Trp Asn Ser Tyr Arg Thr Arg Asp 
                245                 250                 255     


Met Cys Val Thr Pro Phe Ser His Glu Pro Gly Thr Gln Phe Arg Gly 
            260                 265                 270         


Arg Val Asp Gly Asp Trp Phe Arg Phe Arg Asn Gly Ser Gly Gln Glu 
        275                 280                 285             


Val Ala Ala Phe Lys Lys Pro Asp Ala Ser Ser Val Tyr Gly Cys His 
    290                 295                 300                 


Lys Asp Leu Gln Ala Pro Asn Asp His Val Val Gly Pro Ile Ala Arg 
305                 310                 315                 320 


Thr Leu Cys Ala Ala Leu Val Arg Thr Thr Ala Leu Thr Asn Pro Asn 
                325                 330                 335     


Gln Pro Asp Ala Asn Ser Ala Gly Phe Tyr Gln Asp Ala Arg Thr Asn 
            340                 345                 350         


Val Tyr Ala Lys Leu Ala His Gln Gln Met Ala Asn Gly Lys Ala Tyr 
        355                 360                 365             


Ala Phe Ala Phe Asp Asp Val Gly Ala His Glu Ser Leu Val His Asp 
    370                 375                 380                 


Gly Asn Pro Gln Ala Ala Tyr Ile Lys Leu Asp Pro Phe Thr Gly Thr 
385                 390                 395                 400 


Ala Thr Pro Ile Ala Asn Gly Gly Ser Thr Glu Gln Pro Gly Thr Pro 
                405                 410                 415     


Gly Gly Leu Pro Ala Gly Thr Gly Ala Leu Arg Ile Gly Ser Thr Leu 
            420                 425                 430         


Cys Leu Asp Val Pro Trp Ala Asp Pro Thr Asp Thr Asn Gln Val Gln 
        435                 440                 445             


Leu Ala Thr Cys Ser Gly Asn Ala Ala Gln Gln Trp Thr Arg Gly Thr 
    450                 455                 460                 


Asp Gly Thr Val Arg Ala Leu Gly Lys Cys Leu Asp Val Ala Arg Ser 
465                 470                 475                 480 


Gly Thr Ala Asp Gly Thr Ala Val Trp Ile Tyr Thr Cys Asn Gly Thr 
                485                 490                 495     


Gly Ala Gln Lys Trp Thr Tyr Asp Ser Ala Thr Lys Ala Leu Arg Asn 
            500                 505                 510         


Pro Gln Ser Gly Lys Cys Leu Asp Ala Gln Gly Gly Ala Pro Leu Arg 
        515                 520                 525             


Asp Gly Gln Lys Val Gln Leu Trp Thr Cys Asn Gln Thr Glu Ala Gln 
    530                 535                 540                 


Arg Trp Thr Leu 
545             


<210> 8
<211> 337
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Ala His Thr Val Ser Pro Val Asn Pro Asn Ala Gln Gln Thr Thr Lys 
1               5                   10                  15      


Thr Val Met Asn Trp Leu Ala His Leu Pro Asn Arg Thr Glu Asn Arg 
            20                  25                  30          


Val Leu Ser Gly Ala Phe Gly Gly Tyr Ser His Asp Thr Phe Ser Met 
        35                  40                  45              


Ala Glu Ala Asp Arg Ile Arg Ser Ala Thr Gly Gln Ser Pro Ala Ile 
    50                  55                  60                  


Tyr Gly Cys Asp Tyr Ala Arg Gly Trp Leu Glu Thr Ala Asn Ile Glu 
65                  70                  75                  80  


Asp Ser Ile Asp Val Ser Cys Asn Gly Asp Leu Met Ser Tyr Trp Lys 
                85                  90                  95      


Asn Gly Gly Ile Pro Gln Ile Ser Leu His Leu Ala Asn Pro Ala Phe 
            100                 105                 110         


Gln Ser Gly His Phe Lys Thr Pro Ile Thr Asn Asp Gln Tyr Lys Lys 
        115                 120                 125             


Ile Leu Asp Ser Ser Thr Ala Glu Gly Lys Arg Leu Asn Ala Met Leu 
    130                 135                 140                 


Ser Lys Ile Ala Asp Gly Leu Gln Glu Leu Glu Asn Gln Gly Val Pro 
145                 150                 155                 160 


Val Leu Phe Arg Pro Leu His Glu Met Asn Gly Glu Trp Phe Trp Trp 
                165                 170                 175     


Gly Leu Thr Ser Tyr Asn Gln Lys Asp Asn Glu Arg Ile Ser Leu Tyr 
            180                 185                 190         


Lys Gln Leu Tyr Lys Lys Ile Tyr His Tyr Met Thr Asp Thr Arg Gly 
        195                 200                 205             


Leu Asp His Leu Ile Trp Val Tyr Ser Pro Asp Ala Asn Arg Asp Phe 
    210                 215                 220                 


Lys Thr Asp Phe Tyr Pro Gly Ala Ser Tyr Val Asp Ile Val Gly Leu 
225                 230                 235                 240 


Asp Ala Tyr Phe Gln Asp Ala Tyr Ser Ile Asn Gly Tyr Asp Gln Leu 
                245                 250                 255     


Thr Ala Leu Asn Lys Pro Phe Ala Phe Thr Glu Val Gly Pro Gln Thr 
            260                 265                 270         


Ala Asn Gly Ser Phe Asp Tyr Ser Leu Phe Ile Asn Ala Ile Lys Gln 
        275                 280                 285             


Lys Tyr Pro Lys Thr Ile Tyr Phe Leu Ala Trp Asn Asp Glu Trp Ser 
    290                 295                 300                 


Pro Ala Val Asn Lys Gly Ala Ser Ala Leu Tyr His Asp Ser Trp Thr 
305                 310                 315                 320 


Leu Asn Lys Gly Glu Ile Trp Asn Gly Asp Ser Leu Thr Pro Ile Val 
                325                 330                 335     


Glu 
    


<210> 9
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg Thr Pro Val Ser Thr Asn Asp Val Ser Val Glu 
                85                  90                  95      


Lys Arg Ala Ser Gly Tyr Thr Asn Ala Val Tyr Phe Thr Asn Trp Gly 
            100                 105                 110         


Ile Tyr Gly Arg Asn Phe Gln Pro Gln Asp Leu Val Ala Ser Asp Ile 
        115                 120                 125             


Thr His Val Ile Tyr Pro Phe Met Asn Phe Gln Ala Asp Gly Thr Val 
    130                 135                 140                 


Val Ser Gly Asp Ala Tyr Ala Asp Tyr Gln Lys His Tyr Ser Asp Asp 
145                 150                 155                 160 


Ser Trp Asn Asp Val Gly Asn Asn Ala Tyr Gly Cys Val Asn Gln Leu 
                165                 170                 175     


Phe Lys Leu Lys Lys Ala Asn Arg Asn Leu Lys Val Met Leu Ser Ile 
            180                 185                 190         


Gly Gly Trp Thr Trp Ser Thr Asn Phe Pro Ser Ala Ala Ser Thr Asp 
        195                 200                 205             


Ala Asn Arg Lys Asn Phe Ala Lys Thr Ala Ile Thr Phe Met Lys Asp 
    210                 215                 220                 


Trp Gly Phe Asp Gly Ile Asp Val Asp Trp Glu Tyr Pro Ala Asp Asp 
225                 230                 235                 240 


Thr Gln Ala Thr Asn Met Val Leu Leu Leu Lys Glu Ile Arg Ser Gln 
                245                 250                 255     


Leu Asp Ala Tyr Ala Ala Gln Tyr Ala Pro Gly Tyr His Phe Leu Leu 
            260                 265                 270         


Ser Ile Ala Ala Pro Ala Gly Pro Glu His Tyr Ser Ala Leu His Met 
        275                 280                 285             


Ala Asp Leu Gly Gln Val Leu Asp Tyr Val Asn Leu Met Ala Tyr Asp 
    290                 295                 300                 


Tyr Ala Gly Ser Trp Ser Ser Tyr Ser Gly His Asp Ala Asn Leu Phe 
305                 310                 315                 320 


Ala Asn Pro Ser Asn Pro Asn Ser Ser Pro Tyr Asn Thr Asp Gln Ala 
                325                 330                 335     


Ile Lys Ala Tyr Ile Asn Gly Gly Val Pro Ala Ser Lys Ile Val Leu 
            340                 345                 350         


Gly Met Pro Ile Tyr Gly Arg Ser Phe Glu Ser Thr Asn Gly Ile Gly 
        355                 360                 365             


Gln Thr Tyr Asn Gly Ile Gly Ser Gly Ser Trp Glu Asn Gly Ile Trp 
    370                 375                 380                 


Asp Tyr Lys Val Leu Pro Lys Ala Gly Ala Thr Val Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Ala Gln Ala Tyr Tyr Ser Tyr Asp Ser Ser Ser Lys Glu Leu Ile 
                405                 410                 415     


Ser Phe Asp Thr Pro Asp Met Val Ser Lys Lys Val Ser Tyr Leu Lys 
            420                 425                 430         


Asn Leu Gly Leu Gly Gly Ser Met Phe Trp Glu Ala Ser Ala Asp Lys 
        435                 440                 445             


Thr Gly Ser Asp Ser Leu Ile Gly Thr Ser His Arg Ala Leu Gly Ser 
    450                 455                 460                 


Leu Asp Ser Thr Gln Asn Leu Leu Ser Tyr Pro Asn Ser Gln Tyr Asp 
465                 470                 475                 480 


Asn Ile Arg Ser Gly Leu Asn 
                485         


<210> 10
<211> 1935
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
atgggtgcta gagcttctgt tttgtctggt ggtgaattgg atagatggga aaagatcaga       60

ttaagaccag gtggtaagaa gaagtacaag ttgaaacata tcgtttgggc ctccagagaa      120

ttggaaagat ttgctgttaa tccaggcttg ttggaaactt ctgaaggttg cagacaaatc      180

ttgggtcaat tgcaaccatc tttacaaacc ggttctgaag aactgagatc cttgtataat      240

actgttgcta ccttgtactg cgtccatcaa agaattgaaa tcaaggatac caaagaggcc      300

ttggacaaga ttgaagaaga acagaacaag tccaagaaga aggctcaaca agctgctgct      360

gatactggtc attctaatca agtttctcag aactacccaa tcgtccaaaa cattcaaggt      420

caaatggttc atcaagccat ttctccaaga actttgaatg catgggtcaa agttgtagaa      480

gaaaaggctt tttcacctga ggttatccca atgttttctg ctttatctga aggtgctact      540

ccacaagatt tgaacactat gttgaacact gttggtggtc atcaagctgc tatgcaaatg      600

ttgaaagaaa ccattaacga agaggctgct gaatgggata gagttcatcc agttcatgct      660

ggtccaattg cacctggtca aatgagagaa cctagaggtt ctgatattgc tggtactact      720

tctaccttgc aagaacaaat tggttggatg actcataacc caccaattcc agttggtgaa      780

atctacaaga gatggatcat tttgggcttg aacaagatcg tcagaatgta ctctccaacc      840

tccattttgg atattagaca gggtccaaaa gaaccattca gagattacgt tgacagattc      900

tacaagacct tgagagctga acaagcttct caagaggtta agaattggat gaccgaaacc      960

ttgttggttc aaaatgctaa tccagattgc aagaccatct tgaaagcttt aggtccaggt     1020

gctacattgg aagaaatgat gactgcttgt caaggtgtag gtggtccagg tcataaggct     1080

agagttttgg ctgaagctat gtctcaagtt actaatccag ccaccattat gatccaaaag     1140

ggcaacttta gaaaccagag aaagaccgtt aagtgcttca actgtggtaa agaaggtcat     1200

attgctaaga actgtagagc cccaagaaaa aaaggttgtt ggaagtgcgg aaaagagggt     1260

catcaaatga aggattgcac tgaaagacaa gctaacttct tgggtaaaat ttggccatct     1320

cataagggta gaccaggtaa ctttttacaa tctagaccag aacctactgc tccaccagaa     1380

gaatctttta gatttggtga agaaaccacc actccatctc aaaagcaaga acctatcgac     1440

aaagagttgt atccattggc ttcattgaga tctttgttcg gttctgatcc atcatctcaa     1500

ggtggttcta catcttctga attctgctct agaagatata gaggtcctgg tattcataga     1560

ccagttgcta ctatggcttc taacttcact caattcgttt tggttgataa cggtggtact     1620

ggtgatgtta cagttgctcc atctaatttc gctaacggta ttgcagaatg gatctcctct     1680

aattctagat cccaagctta caaggttacc tgctctgtta gacaatcttc tgctcagaat     1740

agaaagtaca ccatcaaggt tgaagttcca aaaggtgctt ggagatctta cttgaacatg     1800

gaattgacca ttccaatttt cgccaccaac tctgattgtg aattgatcgt taaggctatg     1860

cagggtttgt tgaaggatgg taatccaatt ccatctgcta ttgctgctaa ttctggtatc     1920

tatgctgctg cttaa                                                      1935


<210> 11
<211> 1394
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
gtcgacatgg tgtctaaagg tgaagagttg ttcactggtg ttgttccaat tttggttgaa       60

ttggatggtg atgttaacgg ccataagttt tctgtttctg gtgaaggtga gggtgatgct      120

acttatggta aattgacttt gaagttcatc tgcaccacag gtaaattgcc agttccatgg      180

ccaactttgg ttactacttt gacttatggt gtccagtgct tttctagata cccagatcat      240

atgaagcaac acgacttttt caaatccgct atgccagaag gttacgttca agaaagaacc      300

atcttcttca aggatgacgg taactacaaa actagagccg aagttaagtt cgaaggtgat      360

accttggtta acaggattga attgaagggc atcgatttta aagaggacgg taacattttg      420

ggtcacaagt tggagtacaa ctacaactct cataacgttt acatcatggc cgacaagcaa      480

aagaacggta ttaaggttaa cttcaagatc aggcacaaca tcgaagatgg tagtgttcaa      540

ttggctgatc actaccaaca aaacactcca attggtgatg gtccagtttt gttgccagat      600

aaccattact tgtctaccca atctgctttg tctaaggacc caaacgaaaa aagggatcac      660

atggtcttgt tggaatttgt tactgctgct ggtattacct taggtatgga cgaattatac      720

aagtaaggat cctaaggtac ctaattgcct agaaaacatg aggatcaccc atgtctgcag      780

gtcgactcta gaaaacatga ggatcaccca tgtctgcagt attcccgggt tcattagatc      840

ctaaggtacc taattgccta gaaaacatga ggatcaccca tgtctgcagg tcgactctag      900

aaaacatgag gatcacccat gtctgcagta ttcccgggtt cattagatcc taaggtacct      960

aattgcctag aaaacatgag gatcacccat gtctgcaggt cgactccaga aaacatgagg     1020

atcacccatg tctgcagtat tcccgggttc attagatcct aaggtaccta attgcctaga     1080

aaacatgagg atcacccatg tctgcaggtc gactctagaa aacatgagga tcacccatgt     1140

ctgcagtatt cccgggttca ttagatccta aggtacctaa ttgcctagaa aacatgagga     1200

tcacccatgt ctgcaggtcg actctagaaa acatgaggat cacccatgtc tgcagtattc     1260

ccgggttcat tagatcctaa ggtacctaat tgcctagaaa acatgaggat cacccatgtc     1320

tgcaggtcga ctccagaaaa catgaggatc acccatgtct gcagtattcc cgggttcatt     1380

agatctgcgg ccgc                                                       1394


<210> 12
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (16)..(17)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, u, g, unknown or other

<400> 12
nrndsassan casssnnyn                                                    19


<210> 13
<211> 4011
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cgagctcggt acctcgcgaa      420

tgcatctaga tcccaatacc ggtaacctac aaacgggtgg aggatcaccc cacccgacac      480

ttcacaatca aggggtacaa tacacaaggg tggaggaaca ccccaccctc cagacacatt      540

acacagaaat ccaatcaaac agaagcacca tcagggcttc tgctaccaaa tttatctcaa      600

aaaactacaa caaggaatca ccatcaggga ttccctgtgc aatatacgtc aaacgagggc      660

cacgacggga ggacgatcac gcctcccgaa tatcggcatg tctggctttc gaattcagtg      720

cgtggagcat cagcccacgc agccaatcag agtcgaatac aagtcgactt tcgcgaagag      780

catcagcctt cgcgccattc ttacacaaac cacactctcc cctacaggaa cagcatcagc      840

gttcctgccc agtacccaac tcaagaaaat ttatgtcccc atgcagcatc agcgcatggg      900

ccccaagaat acatccccaa caaaatcaca tccgagcacc aacagggctc ggagtgttgt      960

ttcttgtcca actggacaaa ccctccatgg accatcaggc catggactct caccaacaag     1020

acaaaaacta ctcttctcga agcagcatca gcgcttcgaa acactcgagc atacattgtg     1080

cctatttctt gggtggacga tcacgccacc catgctctca cgaatttcaa aacacggaca     1140

aggacgagca ccaccagggc tcgtcgttcc acgtccaata cgattactta cctttcggga     1200

tcacgatcac ggatcccgca gctacatcac ttccactcag gacattcaag catgcacgat     1260

cacggcatgc tccacaagtc tcaaccacag aaactaccaa atgggttcag caccagcgaa     1320

cccactccta cctcaaacct cttcccacaa aactggcaag caggatcacc gcttgcccat     1380

tccaacatac caaatcaaaa acaattactg gtacagcatc agcgtaccag cccacatctc     1440

tcactactat caaaaaccaa accgttcagc aacagcgaac ggtacacacg gaaaaatcaa     1500

ctggtttaca aatacgaaag acgatcacgc tttcgtccag cgcaaactat tacgaaaaac     1560

atccgacggg aagagcaaca gccttcccgc ggcggaaaac ctcacaaaaa cacgacaaac     1620

ggatgcacga acacggcatc cgccgacaac ccacaaactt acaaccaggc aaacggtgca     1680

ggatcaccgc accgtacatc aaacacctca gatctcatat cgatattggg tcatcggatc     1740

ccgggcccgt cgactgcaga ggcctgcatg caagcttggc gtaatcatgg tcatagctgt     1800

ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa catacgagcc ggaagcataa     1860

agtgtaaagc ctggggtgcc taatgagtga gctaactcac attaattgcg ttgcgctcac     1920

tgcccgcttt ccagtcggga aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg     1980

cggggagagg cggtttgcgt attgggcgct cttccgcttc ctcgctcact gactcgctgc     2040

gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta atacggttat     2100

ccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag caaaaggcca     2160

ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc     2220

atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc     2280

aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg     2340

gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta     2400

ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg     2460

ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac     2520

acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag     2580

gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga agaacagtat     2640

ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat     2700

ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc     2760

gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt     2820

ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg atcttcacct     2880

agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat gagtaaactt     2940

ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc tgtctatttc     3000

gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg gagggcttac     3060

catctggccc cagtgctgca atgataccgc gagacccacg ctcaccggct ccagatttat     3120

cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca actttatccg     3180

cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg ccagttaata     3240

gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt gtcacgctcg tcgtttggta     3300

tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc cccatgttgt     3360

gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag     3420

tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg ccatccgtaa     3480

gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc     3540

gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat agcagaactt     3600

taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg atcttaccgc     3660

tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca gcatctttta     3720

ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa     3780

taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat tattgaagca     3840

tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag aaaaataaac     3900

aaataggggt tccgcgcaca tttccccgaa aagtgccacc tgacgtctaa gaaaccatta     3960

ttatcatgac attaacctat aaaaataggc gtatcacgag gccctttcgt c              4011


<210> 14
<211> 551
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Gly Ile Ile Ile Gln Phe Leu Val Val Ser Cys Leu Leu Ala Gly 
1               5                   10                  15      


Ala Gly Gly Leu Asp Pro Ala Ala Leu Met Gln Ile Gly Val Ile Pro 
            20                  25                  30          


Thr Asn Val Arg Gln Leu Met Tyr Tyr Thr Glu Ala Ser Ser Ala Phe 
        35                  40                  45              


Ile Val Val Lys Leu Met Pro Thr Ile Asp Ser Pro Ile Ser Gly Cys 
    50                  55                  60                  


Asn Ile Thr Ser Ile Ser Ser Tyr Asn Ala Thr Val Thr Lys Leu Leu 
65                  70                  75                  80  


Gln Pro Ile Gly Glu Asn Leu Glu Thr Ile Arg Asn Gln Leu Ile Pro 
                85                  90                  95      


Thr Arg Arg Arg Arg Arg Phe Ala Gly Val Val Ile Gly Leu Ala Ala 
            100                 105                 110         


Leu Gly Val Ala Thr Ala Ala Gln Val Thr Ala Ala Val Ala Leu Val 
        115                 120                 125             


Lys Ala Asn Glu Asn Ala Ala Ala Ile Leu Asn Leu Lys Asn Ala Ile 
    130                 135                 140                 


Gln Lys Thr Asn Ala Ala Val Ala Asp Val Val Gln Ala Thr Gln Ser 
145                 150                 155                 160 


Leu Gly Thr Ala Val Gln Ala Val Gln Asp His Ile Asn Ser Val Val 
                165                 170                 175     


Ser Pro Ala Ile Thr Ala Ala Asn Cys Lys Ala Gln Asp Ala Ile Ile 
            180                 185                 190         


Gly Ser Ile Leu Asn Leu Tyr Leu Thr Glu Leu Thr Thr Ile Phe His 
        195                 200                 205             


Asn Gln Ile Thr Asn Pro Ala Leu Ser Pro Ile Thr Ile Gln Ala Leu 
    210                 215                 220                 


Arg Ile Leu Leu Gly Ser Thr Leu Pro Thr Val Val Glu Lys Ser Phe 
225                 230                 235                 240 


Asn Thr Gln Ile Ser Ala Ala Glu Leu Leu Ser Ser Gly Leu Leu Thr 
                245                 250                 255     


Gly Gln Ile Val Gly Leu Asp Leu Thr Tyr Met Gln Met Val Ile Lys 
            260                 265                 270         


Ile Glu Leu Pro Thr Leu Thr Val Gln Pro Ala Thr Gln Ile Ile Asp 
        275                 280                 285             


Leu Ala Thr Ile Ser Ala Phe Ile Asn Asn Gln Glu Val Met Ala Gln 
    290                 295                 300                 


Leu Pro Thr Arg Val Met Val Thr Gly Ser Leu Ile Gln Ala Tyr Pro 
305                 310                 315                 320 


Ala Ser Gln Cys Thr Ile Thr Pro Asn Thr Val Tyr Cys Arg Tyr Asn 
                325                 330                 335     


Asp Ala Gln Val Leu Ser Asp Asp Thr Met Ala Cys Leu Gln Gly Asn 
            340                 345                 350         


Leu Thr Arg Cys Thr Phe Ser Pro Val Val Gly Ser Phe Phe Thr Arg 
        355                 360                 365             


Phe Val Leu Phe Asp Gly Ile Val Tyr Ala Asn Cys Arg Ser Met Leu 
    370                 375                 380                 


Cys Lys Cys Met Gln Pro Ala Ala Val Ile Leu Gln Pro Ser Ser Ser 
385                 390                 395                 400 


Pro Val Thr Val Ile Asp Met Tyr Lys Cys Val Ser Leu Gln Leu Asp 
                405                 410                 415     


Asn Leu Arg Phe Thr Ile Thr Gln Leu Ala Asn Val Thr Tyr Asn Ser 
            420                 425                 430         


Thr Ile Lys Leu Glu Ser Ser Gln Ile Leu Pro Ile Asp Pro Leu Asp 
        435                 440                 445             


Ile Ser Gln Asn Leu Ala Ala Val Asn Lys Ser Leu Ser Asp Ala Leu 
    450                 455                 460                 


Gln His Leu Ala Gln Ser Asp Thr Tyr Leu Ser Ala Ile Thr Ser Ala 
465                 470                 475                 480 


Thr Thr Thr Ser Val Leu Ser Ile Ile Ala Ile Cys Leu Gly Ser Leu 
                485                 490                 495     


Gly Phe Ile Leu Ile Ile Leu Leu Ser Val Val Val Trp Lys Leu Leu 
            500                 505                 510         


Thr Ile Val Ala Ala Asn Arg Asn Arg Met Glu Asn Phe Val Tyr His 
        515                 520                 525             


Asn Gln Ala Phe His His Ser Gln Ser Asp Leu Ser Glu Lys Asn Gln 
    530                 535                 540                 


Pro Ala Thr Leu Gly Thr Arg 
545                 550     


<210> 15
<211> 2255
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Met Ala Gly Ser Arg Glu Ile Leu Leu Pro Glu Val His Leu Asn Ser 
1               5                   10                  15      


Pro Ile Val Lys His Lys Leu Tyr Tyr Tyr Ile Leu Leu Gly Asn Leu 
            20                  25                  30          


Pro Asn Glu Ile Asp Leu Asp Asp Leu Gly Pro Leu His Asn Gln Asn 
        35                  40                  45              


Trp Asn Gln Ile Ala His Glu Glu Ser Asn Leu Ala Gln Arg Leu Val 
    50                  55                  60                  


Asn Val Arg Asn Phe Leu Ile Thr His Ile Pro Asp Leu Arg Lys Gly 
65                  70                  75                  80  


His Trp Gln Glu Tyr Val Asn Val Ile Leu Trp Pro Arg Ile Leu Pro 
                85                  90                  95      


Leu Ile Pro Asp Phe Lys Ile Asn Asp Gln Leu Pro Leu Leu Lys Asn 
            100                 105                 110         


Trp Asp Lys Leu Val Lys Glu Ser Cys Ser Val Ile Asn Ala Gly Thr 
        115                 120                 125             


Ser Gln Cys Ile Gln Asn Leu Ser Tyr Gly Leu Thr Gly Arg Gly Asn 
    130                 135                 140                 


Leu Phe Thr Arg Ser Arg Glu Leu Ser Gly Asp Arg Arg Asp Ile Asp 
145                 150                 155                 160 


Leu Lys Thr Val Val Ala Ala Trp His Asp Ser Asp Trp Lys Arg Ile 
                165                 170                 175     


Ser Asp Phe Trp Ile Met Ile Lys Phe Gln Met Arg Gln Leu Ile Val 
            180                 185                 190         


Arg Gln Thr Asp His Asn Asp Pro Asp Leu Ile Thr Tyr Ile Glu Asn 
        195                 200                 205             


Arg Glu Gly Ile Ile Ile Ile Thr Pro Glu Leu Val Ala Leu Phe Asn 
    210                 215                 220                 


Thr Glu Asn His Thr Leu Thr Tyr Met Thr Phe Glu Ile Val Leu Met 
225                 230                 235                 240 


Ile Ser Asp Met Tyr Glu Gly Arg His Asn Ile Leu Ser Leu Cys Thr 
                245                 250                 255     


Val Ser Thr Tyr Leu Asn Pro Leu Lys Lys Arg Ile Thr Tyr Leu Leu 
            260                 265                 270         


Ser Leu Val Asp Asn Leu Ala Phe Gln Ile Gly Asp Ala Val Tyr Asn 
        275                 280                 285             


Ile Ile Ala Leu Leu Glu Ser Phe Val Tyr Ala Gln Leu Gln Met Ser 
    290                 295                 300                 


Asp Pro Ile Pro Glu Leu Arg Gly Gln Phe His Ala Phe Val Cys Ser 
305                 310                 315                 320 


Glu Ile Leu Asp Ala Leu Arg Gly Thr Asn Ser Phe Thr Gln Asp Glu 
                325                 330                 335     


Leu Arg Thr Val Thr Thr Asn Leu Ile Ser Pro Phe Gln Asp Leu Thr 
            340                 345                 350         


Pro Asp Leu Thr Ala Glu Leu Leu Cys Ile Met Arg Leu Trp Gly His 
        355                 360                 365             


Pro Met Leu Thr Ala Ser Gln Ala Ala Gly Lys Val Arg Glu Ser Met 
    370                 375                 380                 


Cys Ala Gly Lys Val Leu Asp Phe Ser Thr Ile Met Lys Thr Leu Ala 
385                 390                 395                 400 


Phe Phe His Thr Ile Leu Ile Asn Gly Tyr Arg Arg Lys His His Gly 
                405                 410                 415     


Val Trp Pro Pro Leu Asn Leu Pro Gly Asn Ala Ser Lys Gly Leu Thr 
            420                 425                 430         


Glu Leu Met Asn Asp Asn Thr Glu Ile Ser Tyr Glu Phe Thr Leu Lys 
        435                 440                 445             


His Trp Lys Glu Ile Ser Leu Ile Lys Phe Lys Lys Cys Phe Asp Ala 
    450                 455                 460                 


Asp Ala Gly Glu Glu Leu Ser Ile Phe Met Lys Asp Lys Ala Ile Ser 
465                 470                 475                 480 


Ala Pro Lys Gln Asp Trp Met Ser Val Phe Arg Arg Ser Leu Ile Lys 
                485                 490                 495     


Gln Arg His Gln His His Gln Val Pro Leu Pro Asn Pro Phe Asn Arg 
            500                 505                 510         


Arg Leu Leu Leu Asn Phe Leu Glu Asp Asp Lys Phe Asp Pro Asn Val 
        515                 520                 525             


Glu Leu Gln Tyr Val Thr Ser Gly Glu Tyr Leu His Asp Asp Thr Phe 
    530                 535                 540                 


Cys Ala Ser Tyr Ser Leu Lys Glu Lys Glu Ile Lys Pro Asp Gly Arg 
545                 550                 555                 560 


Ile Phe Ala Lys Leu Thr Lys Arg Met Arg Ser Cys Gln Val Ile Ala 
                565                 570                 575     


Glu Ser Leu Leu Ala Asn His Ala Gly Lys Leu Met Lys Glu Asn Gly 
            580                 585                 590         


Val Val Met Asn Gln Leu Ser Leu Thr Lys Ser Leu Leu Thr Met Ser 
        595                 600                 605             


Gln Ile Gly Ile Ile Ser Glu Lys Ala Arg Lys Ser Thr Arg Asp Asn 
    610                 615                 620                 


Ile Asn Gln Pro Gly Phe Gln Asn Ile Gln Arg Asn Lys Ser His His 
625                 630                 635                 640 


Ser Lys Gln Val Asn Gln Arg Asp Pro Ser Asp Asp Phe Glu Leu Ala 
                645                 650                 655     


Ala Ser Phe Leu Thr Thr Asp Leu Lys Lys Tyr Cys Leu Gln Trp Arg 
            660                 665                 670         


Tyr Gln Thr Ile Ile Pro Phe Ala Gln Ser Leu Asn Arg Met Tyr Gly 
        675                 680                 685             


Tyr Pro His Leu Phe Glu Trp Ile His Leu Arg Leu Met Arg Ser Thr 
    690                 695                 700                 


Leu Tyr Val Gly Asp Pro Phe Asn Pro Pro Ala Asp Thr Ser Gln Phe 
705                 710                 715                 720 


Asp Leu Asp Lys Val Ile Asn Gly Asp Ile Phe Ile Val Ser Pro Arg 
                725                 730                 735     


Gly Gly Ile Glu Gly Leu Cys Gln Lys Ala Trp Thr Met Ile Ser Ile 
            740                 745                 750         


Ser Val Ile Ile Leu Ser Ala Thr Glu Ser Gly Thr Arg Val Met Ser 
        755                 760                 765             


Met Val Gln Gly Asp Asn Gln Ala Ile Ala Val Thr Thr Arg Val Pro 
    770                 775                 780                 


Arg Ser Leu Pro Thr Leu Glu Lys Lys Thr Ile Ala Phe Arg Ser Cys 
785                 790                 795                 800 


Asn Leu Phe Phe Glu Arg Leu Lys Cys Asn Asn Phe Gly Leu Gly His 
                805                 810                 815     


His Leu Lys Glu Gln Glu Thr Ile Ile Ser Ser His Phe Phe Val Tyr 
            820                 825                 830         


Ser Lys Arg Ile Phe Tyr Gln Gly Arg Ile Leu Thr Gln Ala Leu Lys 
        835                 840                 845             


Asn Ala Ser Lys Leu Cys Leu Thr Ala Asp Val Leu Gly Glu Cys Thr 
    850                 855                 860                 


Gln Ser Ser Cys Ser Asn Leu Ala Thr Thr Val Met Arg Leu Thr Glu 
865                 870                 875                 880 


Asn Gly Val Glu Lys Asp Ile Cys Phe Tyr Leu Asn Ile Tyr Met Thr 
                885                 890                 895     


Ile Lys Gln Leu Ser Tyr Asp Ile Ile Phe Pro Gln Val Ser Ile Pro 
            900                 905                 910         


Gly Asp Gln Ile Thr Leu Glu Tyr Ile Asn Asn Pro His Leu Val Ser 
        915                 920                 925             


Arg Leu Ala Leu Leu Pro Ser Gln Leu Gly Gly Leu Asn Tyr Leu Ser 
    930                 935                 940                 


Cys Ser Arg Leu Phe Asn Arg Asn Ile Gly Asp Pro Val Val Ser Ala 
945                 950                 955                 960 


Val Ala Asp Leu Lys Arg Leu Ile Lys Ser Gly Cys Met Asp Tyr Trp 
                965                 970                 975     


Ile Leu Tyr Asn Leu Leu Gly Arg Lys Pro Gly Asn Gly Ser Trp Ala 
            980                 985                 990         


Thr Leu Ala Ala Asp Pro Tyr Ser  Ile Asn Ile Glu Tyr  Gln Tyr Pro 
        995                 1000                 1005             


Pro Thr  Thr Ala Leu Lys Arg  His Thr Gln Gln Ala  Leu Met Glu 
    1010                 1015                 1020             


Leu Ser  Thr Asn Pro Met Leu  Arg Gly Ile Phe Ser  Asp Asn Ala 
    1025                 1030                 1035             


Gln Ala  Glu Glu Asn Asn Leu  Ala Arg Phe Leu Leu  Asp Arg Glu 
    1040                 1045                 1050             


Val Val  Phe Pro Arg Val Ala  His Ile Ile Ile Glu  Gln Thr Ser 
    1055                 1060                 1065             


Val Gly  Arg Arg Lys Gln Ile  Gln Gly Tyr Leu Asp  Ser Thr Arg 
    1070                 1075                 1080             


Ser Ile  Met Arg Lys Ser Leu  Glu Ser Lys Pro Leu  Ser Asn Arg 
    1085                 1090                 1095             


Lys Leu  Asn Glu Ile Leu Asp  Tyr Asn Ile Asn Tyr  Leu Ala Tyr 
    1100                 1105                 1110             


Asn Leu  Ala Leu Leu Lys Asn  Ala Ile Glu Pro Pro  Thr Tyr Leu 
    1115                 1120                 1125             


Lys Ala  Met Thr Leu Glu Thr  Cys Ser Ile Asp Ile  Ala Arg Ser 
    1130                 1135                 1140             


Leu Arg  Lys Leu Ser Trp Ala  Pro Leu Leu Gly Gly  Arg Asn Leu 
    1145                 1150                 1155             


Glu Gly  Leu Glu Thr Pro Asp  Pro Ile Glu Ile Thr  Ala Gly Ala 
    1160                 1165                 1170             


Leu Ile  Val Gly Ser Ser Tyr  Cys Glu Gln Cys Ala  Ala Gly Asp 
    1175                 1180                 1185             


Asn Arg  Phe Thr Trp Phe Phe  Leu Pro Ser Gly Ile  Glu Ile Gly 
    1190                 1195                 1200             


Gly Asp  Pro Arg Asp Asn Pro  Pro Ile Arg Val Pro  Tyr Ile Gly 
    1205                 1210                 1215             


Ser Arg  Thr Asp Glu Arg Arg  Val Ala Ser Met Ala  Tyr Ile Arg 
    1220                 1225                 1230             


Gly Ala  Ser Ser Ser Leu Lys  Ala Val Leu Arg Leu  Ala Gly Val 
    1235                 1240                 1245             


Tyr Ile  Trp Ala Phe Gly Asp  Thr Leu Glu Asn Trp  Ile Asp Ala 
    1250                 1255                 1260             


Leu Asp  Leu Ser His Thr Arg  Val Asn Ile Thr Leu  Glu Gln Leu 
    1265                 1270                 1275             


Gln Ser  Leu Thr Pro Leu Pro  Thr Ser Ala Asn Leu  Thr His Arg 
    1280                 1285                 1290             


Leu Asp  Asp Gly Thr Thr Thr  Leu Lys Phe Thr Pro  Ala Ser Ser 
    1295                 1300                 1305             


Tyr Thr  Phe Ser Ser Phe Thr  His Ile Ser Asn Asp  Glu Gln Tyr 
    1310                 1315                 1320             


Leu Thr  Ile Asn Asp Lys Thr  Ala Asp Ser Asn Ile  Ile Tyr Gln 
    1325                 1330                 1335             


Gln Leu  Met Ile Thr Gly Leu  Gly Ile Leu Glu Thr  Trp Asn Asn 
    1340                 1345                 1350             


Pro Pro  Ile Asn Arg Thr Phe  Glu Glu Ser Thr Leu  His Leu His 
    1355                 1360                 1365             


Thr Gly  Ala Ser Cys Cys Val  Arg Pro Val Asp Ser  Cys Ile Ile 
    1370                 1375                 1380             


Ser Glu  Ala Leu Thr Val Lys  Pro His Ile Thr Val  Pro Tyr Ser 
    1385                 1390                 1395             


Asn Lys  Phe Val Phe Asp Glu  Asp Pro Leu Ser Glu  Tyr Glu Thr 
    1400                 1405                 1410             


Ala Lys  Leu Glu Ser Leu Ser  Phe Gln Ala Gln Leu  Gly Asn Ile 
    1415                 1420                 1425             


Asp Ala  Val Asp Met Thr Gly  Lys Leu Thr Leu Leu  Ser Gln Phe 
    1430                 1435                 1440             


Thr Ala  Arg Gln Ile Ile Asn  Ala Ile Thr Gly Leu  Asp Glu Ser 
    1445                 1450                 1455             


Val Ser  Leu Thr Asn Asp Ala  Ile Val Ala Ser Asp  Tyr Val Ser 
    1460                 1465                 1470             


Asn Trp  Ile Ser Glu Cys Met  Tyr Thr Lys Leu Asp  Glu Leu Phe 
    1475                 1480                 1485             


Met Tyr  Cys Gly Trp Glu Leu  Leu Leu Glu Leu Ser  Tyr Gln Met 
    1490                 1495                 1500             


Tyr Tyr  Leu Arg Val Val Gly  Trp Ser Asn Ile Val  Asp Tyr Ser 
    1505                 1510                 1515             


Tyr Met  Ile Leu Arg Arg Ile  Pro Gly Ala Ala Leu  Asn Asn Leu 
    1520                 1525                 1530             


Ala Ser  Thr Leu Ser His Pro  Lys Leu Phe Arg Arg  Ala Ile Asn 
    1535                 1540                 1545             


Leu Asp  Ile Val Ala Pro Leu  Asn Ala Pro His Phe  Ala Ser Leu 
    1550                 1555                 1560             


Asp Tyr  Ile Lys Met Ser Val  Asp Ala Ile Leu Trp  Gly Cys Lys 
    1565                 1570                 1575             


Arg Val  Ile Asn Val Leu Ser  Asn Gly Gly Asp Leu  Glu Leu Val 
    1580                 1585                 1590             


Val Thr  Ser Glu Asp Ser Leu  Ile Leu Ser Asp Arg  Ser Met Asn 
    1595                 1600                 1605             


Leu Ile  Ala Arg Lys Leu Thr  Leu Leu Ser Leu Ile  His His Asn 
    1610                 1615                 1620             


Gly Leu  Glu Leu Pro Lys Ile  Lys Gly Phe Ser Pro  Asp Glu Lys 
    1625                 1630                 1635             


Cys Phe  Ala Leu Thr Glu Phe  Leu Arg Lys Val Val  Asn Ser Gly 
    1640                 1645                 1650             


Leu Ser  Ser Ile Glu Asn Leu  Ser Asn Phe Met Tyr  Asn Val Glu 
    1655                 1660                 1665             


Asn Pro  Arg Leu Ala Ala Phe  Ala Ser Asn Asn Tyr  Tyr Leu Thr 
    1670                 1675                 1680             


Arg Lys  Leu Leu Asn Ser Ile  Arg Asp Thr Glu Ser  Gly Gln Val 
    1685                 1690                 1695             


Ala Val  Thr Ser Tyr Tyr Glu  Ser Leu Glu Tyr Ile  Asp Ser Leu 
    1700                 1705                 1710             


Lys Leu  Thr Pro His Val Pro  Gly Thr Ser Cys Ile  Glu Asp Asp 
    1715                 1720                 1725             


Ser Leu  Cys Ile Asn Asp Tyr  Ile Ile Trp Ile Ile  Glu Ser Asn 
    1730                 1735                 1740             


Ala Asn  Leu Glu Lys Tyr Pro  Ile Pro Asn Ser Pro  Glu Asp Asp 
    1745                 1750                 1755             


Ser Asn  Phe His Asn Phe Lys  Leu Asn Ala Pro Ser  His His Thr 
    1760                 1765                 1770             


Leu Arg  Pro Leu Gly Leu Ser  Ser Thr Ala Trp Tyr  Lys Gly Ile 
    1775                 1780                 1785             


Ser Cys  Cys Arg Tyr Leu Glu  Arg Leu Lys Leu Pro  Gln Gly Asp 
    1790                 1795                 1800             


His Leu  Tyr Ile Ala Glu Gly  Ser Gly Ala Ser Met  Thr Ile Ile 
    1805                 1810                 1815             


Glu Tyr  Leu Phe Pro Gly Arg  Lys Ile Tyr Tyr Asn  Ser Leu Phe 
    1820                 1825                 1830             


Ser Ser  Gly Asp Asn Pro Pro  Gln Arg Asn Tyr Ala  Pro Met Pro 
    1835                 1840                 1845             


Thr Gln  Phe Ile Glu Ser Val  Pro Tyr Lys Leu Trp  Gln Ala His 
    1850                 1855                 1860             


Thr Asp  Gln Tyr Pro Glu Ile  Phe Glu Asp Phe Ile  Pro Leu Trp 
    1865                 1870                 1875             


Asn Gly  Asn Ala Ala Met Thr  Asp Ile Gly Met Thr  Ala Cys Val 
    1880                 1885                 1890             


Glu Phe  Ile Ile Asn Arg Val  Gly Pro Arg Thr Cys  Ser Leu Val 
    1895                 1900                 1905             


His Val  Asp Leu Glu Ser Ser  Ala Ser Leu Asn Gln  Gln Cys Leu 
    1910                 1915                 1920             


Ser Lys  Pro Ile Ile Asn Ala  Ile Ile Thr Ala Thr  Thr Val Leu 
    1925                 1930                 1935             


Cys Pro  His Gly Val Leu Ile  Leu Lys Tyr Ser Trp  Leu Pro Phe 
    1940                 1945                 1950             


Thr Arg  Phe Ser Thr Leu Ile  Thr Phe Leu Trp Cys  Tyr Phe Glu 
    1955                 1960                 1965             


Arg Ile  Thr Val Leu Arg Ser  Thr Tyr Ser Asp Pro  Ala Asn His 
    1970                 1975                 1980             


Glu Val  Tyr Leu Ile Cys Ile  Leu Ala Asn Asn Phe  Ala Phe Gln 
    1985                 1990                 1995             


Thr Val  Ser Gln Ala Thr Gly  Met Ala Met Thr Leu  Thr Asp Gln 
    2000                 2005                 2010             


Gly Phe  Thr Leu Ile Ser Pro  Glu Arg Ile Asn Gln  Tyr Trp Asp 
    2015                 2020                 2025             


Gly His  Leu Lys Gln Glu Arg  Ile Val Ala Glu Ala  Ile Asp Lys 
    2030                 2035                 2040             


Val Val  Leu Gly Glu Asn Ala  Leu Phe Asn Ser Ser  Asp Asn Glu 
    2045                 2050                 2055             


Leu Ile  Leu Lys Cys Gly Gly  Thr Pro Asn Ala Arg  Asn Leu Ile 
    2060                 2065                 2070             


Asp Ile  Glu Pro Val Ala Thr  Phe Ile Glu Phe Glu  Gln Leu Ile 
    2075                 2080                 2085             


Cys Thr  Met Leu Thr Thr His  Leu Lys Glu Ile Ile  Asp Ile Thr 
    2090                 2095                 2100             


Arg Ser  Gly Thr Gln Asp Tyr  Glu Ser Leu Leu Leu  Thr Pro Tyr 
    2105                 2110                 2115             


Asn Leu  Gly Leu Leu Gly Lys  Ile Ser Thr Ile Val  Arg Leu Leu 
    2120                 2125                 2130             


Thr Glu  Arg Ile Leu Asn His  Thr Ile Arg Asn Trp  Leu Ile Leu 
    2135                 2140                 2145             


Pro Pro  Ser Leu Arg Met Ile  Val Lys Gln Asp Leu  Glu Phe Gly 
    2150                 2155                 2160             


Ile Phe  Arg Ile Thr Ser Ile  Phe Asn Ser Asp Arg  Phe Leu Lys 
    2165                 2170                 2175             


Leu Ser  Pro Asn Arg Lys Tyr  Leu Ile Ala Gln Leu  Thr Ala Gly 
    2180                 2185                 2190             


Tyr Ile  Arg Lys Leu Ile Glu  Gly Asp Cys Asn Ile  Asp Leu Thr 
    2195                 2200                 2205             


Arg Pro  Ile Gln Lys Gln Ile  Trp Lys Ala Leu Gly  Cys Val Val 
    2210                 2215                 2220             


Tyr Cys  His Asp Pro Met Asp  Gln Arg Glu Ser Thr  Glu Phe Ile 
    2225                 2230                 2235             


Asp Ile  Asn Ile Asn Glu Glu  Ile Asp Arg Gly Ile  Asp Gly Glu 
    2240                 2245                 2250             


Glu Ile  
    2255 


<210> 16
<211> 509
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Ser Ser Val Leu Lys Ala Tyr Glu Arg Phe Thr Leu Thr Gln Glu 
1               5                   10                  15      


Leu Gln Asp Gln Ser Glu Glu Gly Thr Ile Pro Pro Thr Thr Leu Lys 
            20                  25                  30          


Pro Val Ile Arg Val Phe Ile Leu Thr Ser Asn Asn Pro Glu Leu Arg 
        35                  40                  45              


Ser Arg Leu Leu Leu Phe Cys Leu Arg Ile Val Leu Ser Asn Gly Ala 
    50                  55                  60                  


Arg Asp Ser His Arg Phe Gly Ala Leu Leu Thr Met Phe Ser Leu Pro 
65                  70                  75                  80  


Ser Ala Thr Met Leu Asn His Val Lys Leu Ala Asp Gln Ser Pro Glu 
                85                  90                  95      


Ala Asp Ile Glu Arg Val Glu Ile Asp Gly Phe Glu Glu Gly Ser Phe 
            100                 105                 110         


Arg Leu Ile Pro Asn Ala Arg Ser Gly Met Ser Arg Gly Glu Ile Asn 
        115                 120                 125             


Ala Tyr Ala Ala Leu Ala Glu Asp Leu Pro Asp Thr Leu Asn His Ala 
    130                 135                 140                 


Thr Pro Phe Val Asp Ser Glu Val Glu Gly Thr Ala Trp Asp Glu Ile 
145                 150                 155                 160 


Glu Thr Phe Leu Asp Met Cys Tyr Ser Val Leu Met Gln Ala Trp Ile 
                165                 170                 175     


Val Thr Cys Lys Cys Met Thr Ala Pro Asp Gln Pro Ala Ala Ser Ile 
            180                 185                 190         


Glu Lys Arg Leu Gln Lys Tyr Arg Gln Gln Gly Arg Ile Asn Pro Arg 
        195                 200                 205             


Tyr Leu Leu Gln Pro Glu Ala Arg Arg Ile Ile Gln Asn Val Ile Arg 
    210                 215                 220                 


Lys Gly Met Val Val Arg His Phe Leu Thr Phe Glu Leu Gln Leu Ala 
225                 230                 235                 240 


Arg Ala Gln Ser Leu Val Ser Asn Arg Tyr Tyr Ala Met Val Gly Asp 
                245                 250                 255     


Val Gly Lys Tyr Ile Glu Asn Cys Gly Met Gly Gly Phe Phe Leu Thr 
            260                 265                 270         


Leu Lys Tyr Ala Leu Gly Thr Arg Trp Pro Thr Leu Ala Leu Ala Ala 
        275                 280                 285             


Phe Ser Gly Glu Leu Thr Lys Leu Lys Ser Leu Met Ala Leu Tyr Gln 
    290                 295                 300                 


Thr Leu Gly Glu Gln Ala Arg Tyr Leu Ala Leu Leu Glu Ser Pro His 
305                 310                 315                 320 


Leu Met Asp Phe Ala Ala Ala Asn Tyr Pro Leu Leu Tyr Ser Tyr Ala 
                325                 330                 335     


Met Gly Ile Gly Tyr Val Leu Asp Val Asn Met Arg Asn Tyr Ala Phe 
            340                 345                 350         


Ser Arg Ser Tyr Met Asn Lys Thr Tyr Phe Gln Leu Gly Met Glu Thr 
        355                 360                 365             


Ala Arg Lys Gln Gln Gly Ala Val Asp Met Arg Met Ala Glu Asp Leu 
    370                 375                 380                 


Gly Leu Thr Gln Ala Glu Arg Thr Glu Met Ala Asn Thr Leu Ala Lys 
385                 390                 395                 400 


Leu Thr Thr Ala Asn Arg Gly Ala Asp Thr Arg Gly Gly Val Asn Pro 
                405                 410                 415     


Phe Ser Ser Val Thr Gly Thr Thr Gln Val Pro Ala Ser Ala Thr Gly 
            420                 425                 430         


Asp Thr Phe Glu Gly Tyr Met Ala Ala Asp Arg Leu Arg Gln Arg Tyr 
        435                 440                 445             


Ala Asp Ala Gly Thr Tyr Asp Asp Glu Met Pro Pro Leu Glu Glu Glu 
    450                 455                 460                 


Lys Glu Asp Asp Thr Ser Ala Gly Pro Arg Thr Gly Pro Thr Leu Glu 
465                 470                 475                 480 


Gln Val Ala Leu Asp Ile Gln Asn Ala Ala Val Gly Ala Pro Ile His 
                485                 490                 495     


Thr Asp Asp Leu Asn Ala Ala Leu Gly Asp Leu Asp Ile 
            500                 505                 


<210> 17
<211> 392
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Asp Pro Thr Asp Leu Ser Phe Ser Pro Asp Glu Ile Asn Lys Leu 
1               5                   10                  15      


Ile Glu Thr Gly Leu Asn Thr Val Glu Tyr Phe Thr Ser Gln Gln Val 
            20                  25                  30          


Thr Gly Thr Ser Ser Leu Glu Lys Asn Thr Ile Pro Pro Gly Val Thr 
        35                  40                  45              


Gly Leu Leu Thr Asn Ala Ala Glu Ala Lys Ile Gln Glu Ser Thr Asn 
    50                  55                  60                  


His Gln Lys Gly Ser Val Gly Gly Gly Ala Lys Pro Lys Lys Pro Arg 
65                  70                  75                  80  


Pro Lys Ile Ala Ile Val Pro Ala Asp Asp Lys Thr Val Pro Gly Lys 
                85                  90                  95      


Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Pro Ser Thr Gln 
            100                 105                 110         


Thr Val Leu Asp Leu Ser Gly Lys Thr Leu Pro Ser Gly Ser Tyr Lys 
        115                 120                 125             


Gly Val Lys Leu Ala Lys Phe Gly Lys Glu Asn Leu Met Thr Arg Phe 
    130                 135                 140                 


Ile Glu Glu Pro Arg Glu Asn Pro Ile Ala Thr Ser Phe Pro Ile Asp 
145                 150                 155                 160 


Phe Lys Arg Gly Ala Gly Ile Pro Ala Gly Ser Ile Glu Gly Ser Thr 
                165                 170                 175     


Gln Leu Asp Gly Trp Glu Met Lys Ser Arg Ser Leu Ser Gly Ala Ile 
            180                 185                 190         


His Pro Val Leu Gln Ser Pro Leu Gln Gln Gly Asp Leu Asn Ala Leu 
        195                 200                 205             


Val Thr Ser Val Gln Ser Leu Ala Leu Asn Val Asn Glu Ile Leu Asn 
    210                 215                 220                 


Thr Val Arg Asn Leu Asp Ser Arg Met Asn Gln Leu Glu Thr Lys Val 
225                 230                 235                 240 


Asp Arg Ile Leu Ser Ser Gln Ser Leu Ile Gln Thr Ile Lys Asn Asp 
                245                 250                 255     


Ile Val Gly Leu Lys Ala Gly Met Ala Thr Leu Glu Gly Met Ile Thr 
            260                 265                 270         


Thr Val Lys Ile Met Asp Pro Gly Val Pro Ser Asn Val Thr Val Glu 
        275                 280                 285             


Asp Val Arg Lys Thr Leu Ser Asn His Ala Val Val Val Pro Glu Ser 
    290                 295                 300                 


Phe Asn Asp Ser Phe Leu Thr Gln Ser Glu Asp Val Ile Ser Leu Asp 
305                 310                 315                 320 


Glu Leu Ala Arg Pro Thr Ala Thr Ser Val Lys Lys Ile Val Arg Lys 
                325                 330                 335     


Val Pro Pro Gln Lys Asp Leu Thr Gly Leu Lys Ile Thr Leu Glu Gln 
            340                 345                 350         


Leu Ala Lys Asp Cys Ile Ser Lys Pro Lys Met Arg Glu Glu Tyr Leu 
        355                 360                 365             


Leu Lys Ile Asn Gln Ala Ser Ser Glu Ala Gln Leu Ile Asp Leu Lys 
    370                 375                 380                 


Lys Ala Ile Ile Arg Ser Ala Ile 
385                 390         


<210> 18
<211> 5464
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 18
ggtacccacc agagattggc acccttccag acatatttcg ttcgcaaaga accataaaga       60

taaagaaccc tattcaacat acacctacca ctctccaagg ccaggcgatg attccacgca      120

agagggtatt ttgtggcccg tacactgtgt gaaaaacacc tggggtagta attggttgac      180

caaataatgg accaagtggt cactaagcat attaagattg tatacaaggg tttcttgact      240

gaccgtgaat actactccgc cttccacgac atctggaact tccataagac cgacatgaac      300

aagtacttag aaaagcatca tacagacgag gtttacattg tcggtgtagc tttggagtat      360

tgtgtcaaag ccaccgccat ttccgctgca gaactaggtt ataagaccac tgtcctgctg      420

gattacacaa gacccatcag cgatgatccc gaagtcatca ataaggttaa ggaagagttg      480

aaggcccaca acatcaatgt cgtggataaa taagagctga ataatacttc ttcaacctga      540

tgaactaggg tggcttgcaa atgcacaaat ctatataaca atatctatat atatgtatgt      600

acaccgaatt ccgacatatg gagaaggaat aataaaatat taactaacgt ctttacgcct      660

ctctttattc ttttttgggt aaattgctta aactatttgg ccggcccacc gcgaaaagat      720

ttggctgggc ctcaactaaa cgcgcctttt tggacttttc acgttgcagg gacagcaacg      780

tcaaaacttc tgcattaagg tagtttggta gcttggtagc cactttagta tttctgcctt      840

cttcgaatac cgacattatt tctcgccaat ccacattctc tctccccatc tgcatccttt      900

tatatttaat agggataggt tgttttagtt ctttgattcc gttttcattt caagagcaat      960

aatagcaatt tggaaaaaga aagcaagtaa aagaaagaag agatcttatt ttttgctttt     1020

tctcttgagg tcacatgatc gcaaaatggc aaatggcacg tgaagctgtc gatattgggg     1080

aactgtggtg gttggcaaat gactaattaa gttagtcaag gcgccatcct catgaaaact     1140

gtgtaacata ataaccgaag tgtcgaaaag gtggcacctt gtccaattga acacgctcga     1200

tgaaaaaaat aagatatata taaggttaag taaagcgtct gttagaaagg aagtttttcc     1260

tttttcttgc tctcttgtct tttcatctac tatttccttc gtgtaataca gggtcgtcag     1320

atacatagat acaattctat tacccccatc catacacccg ccgccaccat gccatctcat     1380

ttcgatactg ttcaactaca cgccggccaa gagaaccctg gtgacaatgc tcacagatcc     1440

agagctgtac caatttacgc caccacttct tatgttttcg aaaactctaa gcatggttcg     1500

caattgtttg gtctagaagt tccaggttac gtctattccc gtttccaaaa cccaaccagt     1560

aatgttttgg aagaaagaat tgctgcttta gaaggtggtg ctgctgcttt ggctgtttcc     1620

tccggtcaag ccgctcaaac ccttgccatc caaggtttgg cacacactgg tgacaacatc     1680

gtttccactt cttacttata cggtggtact tataaccagt tcaaaatctc gttcaaaaga     1740

tttggtatcg aggctagatt tgttgaaggt gacaatccag aagaattcga aaaggtcttt     1800

gatgaaagaa ccaaggctgt ttatttggaa accattggta atccaaagta caatgttccg     1860

gattttgaaa aaattgttgc aattgctcac aaacacggta ttccagttgt cgttgacaac     1920

acatttggtg ccggtggtta cttctgtcag ccaattaaat acggtgctga tattgtaaca     1980

cattctgcta ccaaatggat tggtggtcat ggtactacta tcggtggtat tattgttgac     2040

tctggtaagt tcccatggaa ggactaccca gaaaagttcc ctcaattctc tcaacctgcc     2100

gaaggatatc acggtactat ctacaatgaa gcctacggta acttggcata catcgttcat     2160

gttagaactg aactattaag agatttgggt ccattgatga acccatttgc ctctttcttg     2220

ctactacaag gtgttgaaac attatctttg agagctgaaa gacacggtga aaatgcattg     2280

aagttagcca aatggttaga acaatcccca tacgtatctt gggtttcata ccctggttta     2340

gcatctcatt ctcatcatga aaatgctaag aagtatctat ctaacggttt cggtggtgtc     2400

ttatctttcg gtgtaaaaga cttaccaaat gccgacaagg aaactgaccc attcaaactt     2460

tctggtgctc aagttgttga caatttaaag cttgcctcta acttggccaa tgttggtgat     2520

gccaagacct tagtcattgc tccatacttc actacccaca aacaattaaa tgacaaagaa     2580

aagttggcat ctggtgttac caaggactta attcgtgtct ctgttggtat cgaatttatt     2640

gatgacatta ttgcagactt ccagcaatct tttgaaactg ttttcgctgg ccaaaaacca     2700

taataagtgt gcgtaatgag ttgtaaaatt atgtataaac ctccatatcc aacttccaat     2760

ttaatctttc ttttttaatt ttcacttatt tgcgatacag aaagaggatc caacggagca     2820

gtgcggcgcg aggcacatct gcgtttcagg aacgcgaccg gtgaagacga ggacgcacgg     2880

aggagagtct tccttcggag ggctgtcacc cgctcggcgg cttctaatcc gtacttcaat     2940

atagcaatga gcagttaagc gtattactga aagttccaaa gagaaggttt ttttaggcta     3000

agataatggg gctctttaca tttccacaac atataagtaa gattagatat ggatatgtat     3060

atggatatgt atatggtggt aatgccatgt aatatgatta ttaaacttct ttgcgtccat     3120

ccaaaaaaaa agtaagaatt tttggtcgac cccgccgcca ccatgtctaa tttgttgact     3180

gttcatcaaa atttgccagc tttgccagtt gatgcaacgt ctgatgaggt aagaaagaat     3240

ttgatggata tgtttagaga tagacaagca ttctctgaac atacttggaa aatgttgttg     3300

tctgtttgta gatcttgggc tgcttggtgt aaattaaata atagaaaatg gtttccagct     3360

gaaccagaag atgttagaga ttatttgttg tatttgcaag ctagaggttt ggctgttaaa     3420

actatacaac aacatttggg tcaattaaat atgttgcata ggagatctgg tttgcctaga     3480

ccatctgatt ctaatgctgt atctttggtt atgagaagga ttagaaaaga aaatgttgat     3540

gcaggtgaaa gagctaaaca agcattggcg tttgaaagaa ctgattttga tcaagttaga     3600

tctttgatgg aaaattctga tagatgtcaa gatataagaa acttggcttt cttgggaatt     3660

gcttataata cattgttgag aattgctgaa attgctagaa ttagagttaa agacatttct     3720

agaactgatg gtggtagaat gttgattcat attggtagaa ctaaaacatt ggtttcaact     3780

gctggcgttg agaaagcatt gtctttgggt gttactaaat tggttgaaag atggatttct     3840

gtatctggtg tggctgatga cccaaataat tatttatttt gtagagttag aaagaatggt     3900

gttgcggctc catctgctac atctcagctc tctacccgtg ccttggaagg aatttttgaa     3960

gcaactcata gattgattta tggtgctaaa gatgattctg gtcaaagata tttagcatgg     4020

tctggtcatt ctgctagagt tggtgccgct agagatatgg ctagagctgg ggtatctatt     4080

cctgaaatta tgcaagctgg tggttggact aatgttaaca tcgtcatgaa ctatattaga     4140

aatttggatt ctgaaactgg tgcaatggtt agactcttgg aagatggtga ttaataagac     4200

cgcgtcatgt aattagttat gtcacgctta cattcacgcc ctccccccac atccgctcta     4260

accgaaaagg aaggagttag acaacctgaa gtctaggtcc ctatttattt ttttatagtt     4320

atgttagtat taagaacgtt atttatattt caaatttttc ttttttttct gtacagacgc     4380

gtgtacgcat gtaacattat actgaaaacc ttgcttgaga aggttttggg acgctcgaag     4440

gctttaattt gcgaattccg aggctctcct ttcatcatac cctctctaaa taaaatttat     4500

tcctagttat tcctttcttc ttcatatcct taatcatgca ttcactgcca tgtgcaaata     4560

aaggctcttg tggtagaaac ttttagctca aacgtggtaa aactatctca acgtccttcc     4620

gtagacaact ggtgagcagt gcttctgtaa cactgcagat ctccaatgat aaatcgatac     4680

cgtactaact gcccgcacta taatgaactc tttgtatccg taactattta aaatattcat     4740

tcatttctat aagctatatg tttatattta gattagaggg gttaaaagaa agtttttctc     4800

gaaagcttaa ttttagcttt tactttgaac ttctagtaat tgcgaggcag tatcgacaat     4860

gcaatctctg aacttattaa attggaatcc taataaattt ttggttttgc ggttgtcgca     4920

cttgcagcag ttttttgtca aaaaggttga gccgctacca ggttcgccag ttgctatctt     4980

gccttttaac tgtggaaatt cctcattcaa gatatccagc gcttcttgag agcaaaacat     5040

atcttcacat aagaatagtc tttggccagc gcattcgggt ttctcaaatg caagtaaatg     5100

agcttttgaa acatcgcgaa cgtcaataaa aggaccactg taattataaa aattgtcgcc     5160

taatttataa ctaaccaaat tggcaataat ggctgaagag ctatttattc catttctaag     5220

agagtcggca aatagctgag ggccaaaaac aaatcctggg ttgatggttg atagcgtaaa     5280

tttgatgctt gattggtttt cctcgagaaa atcccaagca gttttttcag caaatttctt     5340

ggaaccacag tatgcggaaa ccgcgttagc ttgacaactt tcccaagtat ctttgttcca     5400

actttcctca ttgacaacga aactagtgtc cttcatatct ccgggagatg caagggcagg     5460

tacc                                                                  5464


<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
ttatccgcct ccatccagtc                                                   20


<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
ctgcggccaa cttacttctg                                                   20


<210> 21
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
ccagctttgc cagttgatgc aac                                               23


<210> 22
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
gctctagcca tatctctagc ggcac                                             25


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
ggctgggcct caactaaacg                                                   20


<210> 24
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
cgatgttgtc accagtgtgt gcc                                               23


<210> 25
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
gtgccgctag agatatggct agagc                                             25


<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
ctgctgcaag tgcgacaacc                                                   20


<210> 27
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 27
caggtgcagc tgcaggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgtgccg cctctggacg caccttcagt gaatatgcca tgggctggtt ccgccaggct      120

ccagggaagg aacgtgagtt tgtagcaact attagctgga gtggtggtag cacatactat      180

acagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacggtgtat      240

ctgcaaatga acagcctgaa acctgatgac acggccgttt attactgtgc agcagccggg      300

ttaggtacgg tagtatcgga gtgggattat gactatgact actggggcca ggggacccag      360

gtcaccgtct cctca                                                       375


<210> 28
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 28
gacatccagt tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacagctcca tcaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      300

ccgtacactt ttggccaggg gaccaaggtg gaaatcaaa                             339


<210> 29
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 29
cagatgcagc tggtgcaatc tggaacagag gtgaaaaagc cgggggagtc tctgaagatc       60

tcctgtaagg gttctggata cggctttatc acctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga aaccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcaa caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatat attactgtgc ggggggttcg      300

gggatttcta cccctatgga cgtctggggc caagggacca cggtcaccgt c               351


<210> 30
<211> 1356
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 30
gaggtgcagc tggttgaatc tggcggagga ctggtgcagc ctggcagatc cctgagactg       60

tcttgtgccg ccagcggctt caccttcgac gattatgcca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcacctgga acagcggcca catcgattac      180

gccgatagcg tggaaggccg gttcaccatc agcagagaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgtgc caaggtgtcc      300

tacctgagca ccgccagcag cctggattat tggggacagg gcacactggt caccgtgtct      360

agcgcctcta caaagggccc tagcgtgttc cctctggctc ctagcagcaa gtctacaagc      420

ggaggaacag ccgctctggg ctgcctggtc aaggattact ttcccgagcc tgtgaccgtg      480

tcctggaact ctggcgctct gacaagcggc gtgcacacct ttccagctgt gctgcaaagc      540

agcggcctgt actctctgag cagcgtggtc acagtgccta gctctagcct gggcacccag      600

acctacatct gcaatgtgaa ccacaagcct agcaacacca aggtggacaa gaaggtggaa      660

cccaagagct gcgacaagac ccacacctgt cctccatgtc ctgctccaga actgctcggc      720

ggaccttccg tgttcctgtt tcctccaaag cctaaggaca ccctgatgat cagcagaacc      780

cctgaagtga cctgcgtggt ggtggatgtg tcccacgaag atcccgaagt gaagttcaac      840

tggtacgtgg acggcgtgga agtgcacaat gccaagacca agcctagaga ggaacagtac      900

aacagcacct acagagtggt gtccgtgctg accgtgctgc atcaggattg gctgaacggc      960

aaagagtaca agtgcaaagt gtccaacaag gccctgcctg ctcctatcga gaaaaccatc     1020

tccaaggcca agggccagcc tagagaaccc caggtttaca cactgcctcc aagcagggac     1080

gagctgacca agaatcaggt gtccctgacc tgcctcgtga agggcttcta cccttccgat     1140

atcgccgtgg aatgggagag caatggccag cctgagaaca actacaagac aacccctcct     1200

gtgctggaca gcgacggctc attcttcctg tacagcaagc tgacagtgga caagtccaga     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1320

acccagaagt ccctgagcct gtctcctggc aaataa                               1356


<210> 31
<211> 645
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc       60

atcacctgta gagccagcca gggcatcaga aactacctgg cctggtatca gcagaagccc      120

ggcaaggctc ctaagctgct gatctacgcc gccagcacac tgcagtctgg cgtgccatct      180

agattttccg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct      240

gaggacgtgg ccacctacta ctgccagaga tacaacagag ccccttacac cttcggccag      300

ggcaccaagg tggaaatcaa gagaacagtg gccgctccta gcgtgttcat cttcccacct      360

tccgacgagc agctgaaaag cggcacagcc tctgtcgtgt gcctgctgaa caacttctac      420

cccagagaag ccaaggtgca gtggaaggtg gacaacgctc tgcagtccgg caacagccaa      480

gagagcgtga cagagcagga cagcaaggac tccacctaca gcctgagcag caccctgaca      540

ctgagcaagg ccgactacga gaagcacaaa gtgtacgcct gcgaagtgac ccaccagggc      600

ctttctagcc ctgtgaccaa gagcttcaac cggggcgaat gttaa                      645


<210> 32
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 32
atggccctgt ggatgcgcct cctgcccctg ctggcgctgc tggccctctg gggacctgac       60

ccagccgcag cctttgtgaa ccaacacctg tgcggctcac acctggtgga agctctctac      120

ctagtgtgcg gggaacgagg cttcttctac acacccaaga cccgccggga ggcagaggac      180

ctgcaggtgg ggcaggtgga gctgggcggg ggccctggtg caggcagcct gcagcccttg      240

gccctggagg ggtccctgca gaagcgtggc attgtggaac aatgctgtac cagcatctgc      300

tccctctacc agctggagaa ctactgcaac tag                                   333


<210> 33
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Ser Thr Ser Ser Glu Phe Cys Ser Arg Arg Tyr Arg Gly Pro Gly Ile 
1               5                   10                  15      


His Arg Pro Val Ala Thr 
            20          


