                               SEQUENCE LISTING

<110> CATAMARAN BIO, INC.
 
<120> CELLULAR THERAPEUTICS ENGINEERED WITH SIGNAL MODULATORS AND 
      METHODS OF USE THEREOF

<130> 52526-0018WO1

<140>
<141>

<150> 63/118,008
<151> 2020-11-25

<160> 687   

<170> PatentIn version 3.5

<210> 1
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1
Gly Gly 
1       


<210> 2
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 2
Ala Ala 
1       


<210> 3
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="Ala"

<220>
<221> SITE
<222> (1)..(5)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 3
Leu Pro Xaa Thr Gly
1               5   


<210> 4
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 4
Leu Pro Xaa Thr Gly Gly 
1               5       


<210> 5
<211> 127
<212> PRT
<213> Homo sapiens

<400> 5
Lys Glu Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His 
1               5                   10                  15      


Ser Ile Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr 
            20                  25                  30          


Cys Ala Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr 
        35                  40                  45              


Cys Val Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn 
    50                  55                  60                  


Ile Ser Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn 
65                  70                  75                  80  


Gly Ser Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser 
                85                  90                  95      


His Ser Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg 
            100                 105                 110         


Pro Ser Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg 
        115                 120                 125         


<210> 6
<211> 138
<212> PRT
<213> Homo sapiens

<400> 6
Gly Cys Ile Asn Ile Thr Ser Ser Ala Ser Gln Glu Gly Thr Arg Leu 
1               5                   10                  15      


Asn Leu Ile Cys Thr Val Trp His Lys Lys Glu Glu Ala Glu Gly Phe 
            20                  25                  30          


Val Val Phe Leu Cys Lys Asp Arg Ser Gly Asp Cys Ser Pro Glu Thr 
        35                  40                  45              


Ser Leu Lys Gln Leu Arg Leu Lys Arg Asp Pro Gly Ile Asp Gly Val 
    50                  55                  60                  


Gly Glu Ile Ser Ser Gln Leu Met Phe Thr Ile Ser Gln Val Thr Pro 
65                  70                  75                  80  


Leu His Ser Gly Thr Tyr Gln Cys Cys Ala Arg Ser Gln Lys Ser Gly 
                85                  90                  95      


Ile Arg Leu Gln Gly His Phe Phe Ser Ile Leu Phe Thr Glu Thr Gly 
            100                 105                 110         


Asn Tyr Thr Val Thr Gly Leu Lys Gln Arg Gln His Leu Glu Phe Ser 
        115                 120                 125             


His Asn Glu Gly Thr Leu Ser Ser Gly Phe 
    130                 135             


<210> 7
<211> 215
<212> PRT
<213> Homo sapiens

<400> 7
Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu 
1               5                   10                  15      


Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys 
            20                  25                  30          


Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile 
        35                  40                  45              


Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys Glu Thr 
    50                  55                  60                  


Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val 
65                  70                  75                  80  


Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Pro Val Ala Ile 
                85                  90                  95      


Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn 
            100                 105                 110         


Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr 
        115                 120                 125             


Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly 
    130                 135                 140                 


Lys Pro Ala Ala Gln Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr 
145                 150                 155                 160 


Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys 
                165                 170                 175     


His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His Val Ser His 
            180                 185                 190         


Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly 
        195                 200                 205             


Ala Lys Lys Ser Ala Lys Leu 
    210                 215 


<210> 8
<211> 242
<212> PRT
<213> Homo sapiens

<400> 8
Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
        115                 120                 125             


Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu 
    130                 135                 140                 


Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
145                 150                 155                 160 


Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His 
                165                 170                 175     


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
            180                 185                 190         


Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg 
        195                 200                 205             


Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly 
    210                 215                 220                 


Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val 
225                 230                 235                 240 


Val His 
        


<210> 9
<211> 394
<212> PRT
<213> Homo sapiens

<400> 9
Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly Tyr Ser 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val Gly Tyr 
        35                  40                  45              


Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser Gly Arg 
    50                  55                  60                  


Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn Asp Thr 
                165                 170                 175     


Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn Arg Ser 
            180                 185                 190         


Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro Thr Ile 
        195                 200                 205             


Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser Leu Ser 
    210                 215                 220                 


Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asn 
225                 230                 235                 240 


Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr 
                245                 250                 255     


Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser Val Thr 
            260                 265                 270         


Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu Leu Ser 
        275                 280                 285             


Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr Val Thr 
    290                 295                 300                 


Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp Thr Gly 
305                 310                 315                 320 


Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser Ser Glu 
                325                 330                 335     


Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn Pro Val 
            340                 345                 350         


Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn Pro Ile 
        355                 360                 365             


Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr Asn Ala 
    370                 375                 380                 


Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly 
385                 390                 


<210> 10
<211> 126
<212> PRT
<213> Homo sapiens

<400> 10
Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210> 11
<211> 148
<212> PRT
<213> Homo sapiens

<400> 11
Gln Val Thr Asp Ile Asn Ser Lys Gly Leu Glu Leu Arg Lys Thr Val 
1               5                   10                  15      


Thr Thr Val Glu Thr Gln Asn Leu Glu Gly Leu His His Asp Gly Gln 
            20                  25                  30          


Phe Cys His Lys Pro Cys Pro Pro Gly Glu Arg Lys Ala Arg Asp Cys 
        35                  40                  45              


Thr Val Asn Gly Asp Glu Pro Asp Cys Val Pro Cys Gln Glu Gly Lys 
    50                  55                  60                  


Glu Tyr Thr Asp Lys Ala His Phe Ser Ser Lys Cys Arg Arg Cys Arg 
65                  70                  75                  80  


Leu Cys Asp Glu Gly His Gly Leu Glu Val Glu Ile Asn Cys Thr Arg 
                85                  90                  95      


Thr Gln Asn Thr Lys Cys Arg Cys Lys Pro Asn Phe Phe Cys Asn Ser 
            100                 105                 110         


Thr Val Cys Glu His Cys Asp Pro Cys Thr Lys Cys Glu His Gly Ile 
        115                 120                 125             


Ile Lys Glu Cys Thr Leu Thr Ser Asn Thr Lys Cys Lys Glu Glu Gly 
    130                 135                 140                 


Ser Arg Ser Asn 
145             


<210> 12
<211> 288
<212> PRT
<213> Homo sapiens

<400> 12
Leu Tyr Leu Gln Ala Trp Pro Asn Pro Val Phe Glu Gly Asp Ala Leu 
1               5                   10                  15      


Thr Leu Arg Cys Gln Gly Trp Lys Asn Thr Pro Leu Ser Gln Val Lys 
            20                  25                  30          


Phe Tyr Arg Asp Gly Lys Phe Leu His Phe Ser Lys Glu Asn Gln Thr 
        35                  40                  45              


Leu Ser Met Gly Ala Ala Thr Val Gln Ser Arg Gly Gln Tyr Ser Cys 
    50                  55                  60                  


Ser Gly Gln Val Met Tyr Ile Pro Gln Thr Phe Thr Gln Thr Ser Glu 
65                  70                  75                  80  


Thr Ala Met Val Gln Val Gln Glu Leu Phe Pro Pro Pro Val Leu Ser 
                85                  90                  95      


Ala Ile Pro Ser Pro Glu Pro Arg Glu Gly Ser Leu Val Thr Leu Arg 
            100                 105                 110         


Cys Gln Thr Lys Leu His Pro Leu Arg Ser Ala Leu Arg Leu Leu Phe 
        115                 120                 125             


Ser Phe His Lys Asp Gly His Thr Leu Gln Asp Arg Gly Pro His Pro 
    130                 135                 140                 


Glu Leu Cys Ile Pro Gly Ala Lys Glu Gly Asp Ser Gly Leu Tyr Trp 
145                 150                 155                 160 


Cys Glu Val Ala Pro Glu Gly Gly Gln Val Gln Lys Gln Ser Pro Gln 
                165                 170                 175     


Leu Glu Val Arg Val Gln Ala Pro Val Ser Arg Pro Val Leu Thr Leu 
            180                 185                 190         


His His Gly Pro Ala Asp Pro Ala Val Gly Asp Met Val Gln Leu Leu 
        195                 200                 205             


Cys Glu Ala Gln Arg Gly Ser Pro Pro Ile Leu Tyr Ser Phe Tyr Leu 
    210                 215                 220                 


Asp Glu Lys Ile Val Gly Asn His Ser Ala Pro Cys Gly Gly Thr Thr 
225                 230                 235                 240 


Ser Leu Leu Phe Pro Val Lys Ser Glu Gln Asp Ala Gly Asn Tyr Ser 
                245                 250                 255     


Cys Glu Ala Glu Asn Ser Val Ser Arg Glu Arg Ser Glu Pro Lys Lys 
            260                 265                 270         


Leu Ser Leu Lys Gly Ser Gln Val Leu Phe Thr Pro Ala Ser Asn Trp 
        275                 280                 285             


<210> 13
<211> 214
<212> PRT
<213> Homo sapiens

<400> 13
His Gly Thr Glu Leu Pro Ser Pro Pro Ser Val Trp Phe Glu Ala Glu 
1               5                   10                  15      


Phe Phe His His Ile Leu His Trp Thr Pro Ile Pro Asn Gln Ser Glu 
            20                  25                  30          


Ser Thr Cys Tyr Glu Val Ala Leu Leu Arg Tyr Gly Ile Glu Ser Trp 
        35                  40                  45              


Asn Ser Ile Ser Asn Cys Ser Gln Thr Leu Ser Tyr Asp Leu Thr Ala 
    50                  55                  60                  


Val Thr Leu Asp Leu Tyr His Ser Asn Gly Tyr Arg Ala Arg Val Arg 
65                  70                  75                  80  


Ala Val Asp Gly Ser Arg His Ser Asn Trp Thr Val Thr Asn Thr Arg 
                85                  90                  95      


Phe Ser Val Asp Glu Val Thr Leu Thr Val Gly Ser Val Asn Leu Glu 
            100                 105                 110         


Ile His Asn Gly Phe Ile Leu Gly Lys Ile Gln Leu Pro Arg Pro Lys 
        115                 120                 125             


Met Ala Pro Ala Asn Asp Thr Tyr Glu Ser Ile Phe Ser His Phe Arg 
    130                 135                 140                 


Glu Tyr Glu Ile Ala Ile Arg Lys Val Pro Gly Asn Phe Thr Phe Thr 
145                 150                 155                 160 


His Lys Lys Val Lys His Glu Asn Phe Ser Leu Leu Thr Ser Gly Glu 
                165                 170                 175     


Val Gly Glu Phe Cys Val Gln Val Lys Pro Ser Val Ala Ser Arg Ser 
            180                 185                 190         


Asn Lys Gly Met Trp Ser Lys Glu Glu Cys Ile Ser Leu Thr Arg Gln 
        195                 200                 205             


Tyr Phe Thr Val Thr Asn 
    210                 


<210> 14
<211> 201
<212> PRT
<213> Homo sapiens

<400> 14
Met Val Pro Pro Pro Glu Asn Val Arg Met Asn Ser Val Asn Phe Lys 
1               5                   10                  15      


Asn Ile Leu Gln Trp Glu Ser Pro Ala Phe Ala Lys Gly Asn Leu Thr 
            20                  25                  30          


Phe Thr Ala Gln Tyr Leu Ser Tyr Arg Ile Phe Gln Asp Lys Cys Met 
        35                  40                  45              


Asn Thr Thr Leu Thr Glu Cys Asp Phe Ser Ser Leu Ser Lys Tyr Gly 
    50                  55                  60                  


Asp His Thr Leu Arg Val Arg Ala Glu Phe Ala Asp Glu His Ser Asp 
65                  70                  75                  80  


Trp Val Asn Ile Thr Phe Cys Pro Val Asp Asp Thr Ile Ile Gly Pro 
                85                  90                  95      


Pro Gly Met Gln Val Glu Val Leu Ala Asp Ser Leu His Met Arg Phe 
            100                 105                 110         


Leu Ala Pro Lys Ile Glu Asn Glu Tyr Glu Thr Trp Thr Met Lys Asn 
        115                 120                 125             


Val Tyr Asn Ser Trp Thr Tyr Asn Val Gln Tyr Trp Lys Asn Gly Thr 
    130                 135                 140                 


Asp Glu Lys Phe Gln Ile Thr Pro Gln Tyr Asp Phe Glu Val Leu Arg 
145                 150                 155                 160 


Asn Leu Glu Pro Trp Thr Thr Tyr Cys Val Gln Val Arg Gly Phe Leu 
                165                 170                 175     


Pro Asp Arg Asn Lys Ala Gly Glu Trp Ser Glu Pro Val Cys Glu Gln 
            180                 185                 190         


Thr Thr His Asp Glu Thr Val Pro Ser 
        195                 200     


<210> 15
<211> 118
<212> PRT
<213> Homo sapiens

<400> 15
Met Pro Gly Val Cys Asp Arg Ala Pro Asp Phe Leu Ser Pro Ser Glu 
1               5                   10                  15      


Asp Gln Val Leu Arg Pro Ala Leu Gly Ser Ser Val Ala Leu Asn Cys 
            20                  25                  30          


Thr Ala Trp Val Val Ser Gly Pro His Cys Ser Leu Pro Ser Val Gln 
        35                  40                  45              


Trp Leu Lys Asp Gly Leu Pro Leu Gly Ile Gly Gly His Tyr Ser Leu 
    50                  55                  60                  


His Glu Tyr Ser Trp Val Lys Ala Asn Leu Ser Glu Val Leu Val Ser 
65                  70                  75                  80  


Ser Val Leu Gly Val Asn Val Thr Ser Thr Glu Val Tyr Gly Ala Phe 
                85                  90                  95      


Thr Cys Ser Ile Gln Asn Ile Ser Phe Ser Ser Phe Thr Leu Gln Arg 
            100                 105                 110         


Ala Gly Pro Thr Ser His 
        115             


<210> 16
<211> 346
<212> PRT
<213> Homo sapiens

<400> 16
Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg Gly Val Leu 
1               5                   10                  15      


Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro Gly Val Glu 
            20                  25                  30          


Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys Pro Ala Ala 
        35                  40                  45              


Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg Leu Leu Leu 
    50                  55                  60                  


Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys Tyr Arg Ala 
65                  70                  75                  80  


Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val Pro Pro Glu 
                85                  90                  95      


Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser Asn Val Val 
            100                 105                 110         


Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr Lys Ala Val 
        115                 120                 125             


Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp Phe Gln Glu 
    130                 135                 140                 


Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys Gln Leu Ala 
145                 150                 155                 160 


Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met Cys Val Ala 
                165                 170                 175     


Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe Gln Gly Cys 
            180                 185                 190         


Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val Thr Ala Val 
        195                 200                 205             


Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp Pro His Ser 
    210                 215                 220                 


Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg Tyr Arg Ala 
225                 230                 235                 240 


Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp Leu Gln His 
                245                 250                 255     


His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His Val Val Gln 
            260                 265                 270         


Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser Glu Trp Ser 
        275                 280                 285             


Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser Pro Pro Ala 
    290                 295                 300                 


Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr Asn Lys Asp 
305                 310                 315                 320 


Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr Ser Leu Pro 
                325                 330                 335     


Val Gln Asp Ser Ser Ser Val Pro Leu Pro 
            340                 345     


<210> 17
<211> 597
<212> PRT
<213> Homo sapiens

<400> 17
Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser Pro Glu Ser Pro Val Val 
1               5                   10                  15      


Gln Leu His Ser Asn Phe Thr Ala Val Cys Val Leu Lys Glu Lys Cys 
            20                  25                  30          


Met Asp Tyr Phe His Val Asn Ala Asn Tyr Ile Val Trp Lys Thr Asn 
        35                  40                  45              


His Phe Thr Ile Pro Lys Glu Gln Tyr Thr Ile Ile Asn Arg Thr Ala 
    50                  55                  60                  


Ser Ser Val Thr Phe Thr Asp Ile Ala Ser Leu Asn Ile Gln Leu Thr 
65                  70                  75                  80  


Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu Gln Asn Val Tyr Gly Ile 
                85                  90                  95      


Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys Pro Lys Asn Leu Ser Cys 
            100                 105                 110         


Ile Val Asn Glu Gly Lys Lys Met Arg Cys Glu Trp Asp Gly Gly Arg 
        115                 120                 125             


Glu Thr His Leu Glu Thr Asn Phe Thr Leu Lys Ser Glu Trp Ala Thr 
    130                 135                 140                 


His Lys Phe Ala Asp Cys Lys Ala Lys Arg Asp Thr Pro Thr Ser Cys 
145                 150                 155                 160 


Thr Val Asp Tyr Ser Thr Val Tyr Phe Val Asn Ile Glu Val Trp Val 
                165                 170                 175     


Glu Ala Glu Asn Ala Leu Gly Lys Val Thr Ser Asp His Ile Asn Phe 
            180                 185                 190         


Asp Pro Val Tyr Lys Val Lys Pro Asn Pro Pro His Asn Leu Ser Val 
        195                 200                 205             


Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr Asn 
    210                 215                 220                 


Pro Ser Ile Lys Ser Val Ile Ile Leu Lys Tyr Asn Ile Gln Tyr Arg 
225                 230                 235                 240 


Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr Ala 
                245                 250                 255     


Ser Thr Arg Ser Ser Phe Thr Val Gln Asp Leu Lys Pro Phe Thr Glu 
            260                 265                 270         


Tyr Val Phe Arg Ile Arg Cys Met Lys Glu Asp Gly Lys Gly Tyr Trp 
        275                 280                 285             


Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile Thr Tyr Glu Asp Arg Pro 
    290                 295                 300                 


Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile Asp Pro Ser His Thr Gln 
305                 310                 315                 320 


Gly Tyr Arg Thr Val Gln Leu Val Trp Lys Thr Leu Pro Pro Phe Glu 
                325                 330                 335     


Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val Thr Leu Thr Arg Trp Lys 
            340                 345                 350         


Ser His Leu Gln Asn Tyr Thr Val Asn Ala Thr Lys Leu Thr Val Asn 
        355                 360                 365             


Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu Thr Val Arg Asn Leu Val 
    370                 375                 380                 


Gly Lys Ser Asp Ala Ala Val Leu Thr Ile Pro Ala Cys Asp Phe Gln 
385                 390                 395                 400 


Ala Thr His Pro Val Met Asp Leu Lys Ala Phe Pro Lys Asp Asn Met 
                405                 410                 415     


Leu Trp Val Glu Trp Thr Thr Pro Arg Glu Ser Val Lys Lys Tyr Ile 
            420                 425                 430         


Leu Glu Trp Cys Val Leu Ser Asp Lys Ala Pro Cys Ile Thr Asp Trp 
        435                 440                 445             


Gln Gln Glu Asp Gly Thr Val His Arg Thr Tyr Leu Arg Gly Asn Leu 
    450                 455                 460                 


Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val Thr Pro Val Tyr Ala Asp 
465                 470                 475                 480 


Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala Tyr Leu Lys Gln Ala Pro 
                485                 490                 495     


Pro Ser Lys Gly Pro Thr Val Arg Thr Lys Lys Val Gly Lys Asn Glu 
            500                 505                 510         


Ala Val Leu Glu Trp Asp Gln Leu Pro Val Asp Val Gln Asn Gly Phe 
        515                 520                 525             


Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr Ile Ile Gly Asn Glu Thr 
    530                 535                 540                 


Ala Val Asn Val Asp Ser Ser His Thr Glu Tyr Thr Leu Ser Ser Leu 
545                 550                 555                 560 


Thr Ser Asp Thr Leu Tyr Met Val Arg Met Ala Ala Tyr Thr Asp Glu 
                565                 570                 575     


Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe Thr Thr Pro Lys Phe Ala 
            580                 585                 590         


Gln Gly Glu Ile Glu 
        595         


<210> 18
<211> 224
<212> PRT
<213> Homo sapiens

<400> 18
His Glu Gly Val His Arg Lys Pro Ser Leu Leu Ala His Pro Gly Pro 
1               5                   10                  15      


Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln Cys Trp Ser Asp Val 
            20                  25                  30          


Met Phe Glu His Phe Leu Leu His Arg Glu Gly Met Phe Asn Asp Thr 
        35                  40                  45              


Leu Arg Leu Ile Gly Glu His His Asp Gly Val Ser Lys Ala Asn Phe 
    50                  55                  60                  


Ser Ile Ser Arg Met Thr Gln Asp Leu Ala Gly Thr Tyr Arg Cys Tyr 
65                  70                  75                  80  


Gly Ser Val Thr His Ser Pro Tyr Gln Val Ser Ala Pro Ser Asp Pro 
                85                  90                  95      


Leu Asp Ile Val Ile Ile Gly Leu Tyr Glu Lys Pro Ser Leu Ser Ala 
            100                 105                 110         


Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Asn Val Thr Leu Ser Cys 
        115                 120                 125             


Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu Ser Arg Glu Gly Glu 
    130                 135                 140                 


Ala His Glu Arg Arg Leu Pro Ala Gly Pro Lys Val Asn Gly Thr Phe 
145                 150                 155                 160 


Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Arg 
                165                 170                 175     


Cys Phe Gly Ser Phe His Asp Ser Pro Tyr Glu Trp Ser Lys Ser Ser 
            180                 185                 190         


Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser Asn Ser Trp Pro 
        195                 200                 205             


Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn Pro Arg His Leu His 
    210                 215                 220                 


<210> 19
<211> 224
<212> PRT
<213> Homo sapiens

<400> 19
His Glu Gly Val His Arg Lys Pro Ser Leu Leu Ala His Pro Gly Arg 
1               5                   10                  15      


Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln Cys Trp Ser Asp Val 
            20                  25                  30          


Arg Phe Glu His Phe Leu Leu His Arg Glu Gly Lys Phe Lys Asp Thr 
        35                  40                  45              


Leu His Leu Ile Gly Glu His His Asp Gly Val Ser Lys Ala Asn Phe 
    50                  55                  60                  


Ser Ile Gly Pro Met Met Gln Asp Leu Ala Gly Thr Tyr Arg Cys Tyr 
65                  70                  75                  80  


Gly Ser Val Thr His Ser Pro Tyr Gln Leu Ser Ala Pro Ser Asp Pro 
                85                  90                  95      


Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro Ser Leu Ser Ala 
            100                 105                 110         


Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser Val Thr Leu Ser Cys 
        115                 120                 125             


Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu Ser Arg Glu Gly Glu 
    130                 135                 140                 


Ala His Glu Cys Arg Phe Ser Ala Gly Pro Lys Val Asn Gly Thr Phe 
145                 150                 155                 160 


Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Arg 
                165                 170                 175     


Cys Phe Gly Ser Phe Arg Asp Ser Pro Tyr Glu Trp Ser Asn Ser Ser 
            180                 185                 190         


Asp Pro Leu Leu Val Ser Val Ile Gly Asn Pro Ser Asn Ser Trp Pro 
        195                 200                 205             


Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn Pro Arg His Leu His 
    210                 215                 220                 


<210> 20
<211> 224
<212> PRT
<213> Homo sapiens

<400> 20
His Glu Gly Val His Arg Lys Pro Ser Leu Leu Ala His Pro Gly Pro 
1               5                   10                  15      


Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln Cys Trp Ser Asp Val 
            20                  25                  30          


Arg Phe Gln His Phe Leu Leu His Arg Glu Gly Lys Phe Lys Asp Thr 
        35                  40                  45              


Leu His Leu Ile Gly Glu His His Asp Gly Val Ser Lys Ala Asn Phe 
    50                  55                  60                  


Ser Ile Gly Pro Met Met Gln Asp Leu Ala Gly Thr Tyr Arg Cys Tyr 
65                  70                  75                  80  


Gly Ser Val Thr His Ser Pro Tyr Gln Leu Ser Ala Pro Ser Asp Pro 
                85                  90                  95      


Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro Ser Leu Ser Ala 
            100                 105                 110         


Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser Val Thr Leu Ser Cys 
        115                 120                 125             


Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu Ser Arg Glu Gly Glu 
    130                 135                 140                 


Ala His Glu Arg Arg Phe Ser Ala Gly Pro Lys Val Asn Gly Thr Phe 
145                 150                 155                 160 


Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Arg 
                165                 170                 175     


Cys Phe Gly Ser Phe Arg Asp Ser Pro Tyr Glu Trp Ser Asn Ser Ser 
            180                 185                 190         


Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser Asn Ser Trp Pro 
        195                 200                 205             


Ser Pro Thr Glu Pro Ser Ser Glu Thr Gly Asn Pro Arg His Leu His 
    210                 215                 220                 


<210> 21
<211> 217
<212> PRT
<213> Homo sapiens

<400> 21
His Glu Gly Gly Gln Asp Lys Pro Leu Leu Ser Ala Trp Pro Ser Ala 
1               5                   10                  15      


Val Val Pro Arg Gly Gly His Val Thr Leu Leu Cys Arg Ser Arg Leu 
            20                  25                  30          


Gly Phe Thr Ile Phe Ser Leu Tyr Lys Glu Asp Gly Val Pro Val Pro 
        35                  40                  45              


Glu Leu Tyr Asn Lys Ile Phe Trp Lys Ser Ile Leu Met Gly Pro Val 
    50                  55                  60                  


Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg Gly Ser His Pro Arg 
65                  70                  75                  80  


Ser Pro Ile Glu Trp Ser Ala Pro Ser Asn Pro Leu Val Ile Val Val 
                85                  90                  95      


Thr Gly Leu Phe Gly Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr 
            100                 105                 110         


Val Arg Thr Gly Glu Asn Val Thr Leu Ser Cys Ser Ser Arg Ser Ser 
        115                 120                 125             


Phe Asp Met Tyr His Leu Ser Arg Glu Gly Arg Ala His Glu Pro Arg 
    130                 135                 140                 


Leu Pro Ala Val Pro Ser Val Asn Gly Thr Phe Gln Ala Asp Phe Pro 
145                 150                 155                 160 


Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Thr Cys Phe Gly Ser Leu 
                165                 170                 175     


His Asp Ser Pro Tyr Glu Trp Ser Asp Pro Ser Asp Pro Leu Leu Val 
            180                 185                 190         


Ser Val Thr Gly Asn Ser Ser Ser Ser Ser Ser Ser Pro Thr Glu Pro 
        195                 200                 205             


Ser Ser Lys Thr Gly Ile Arg Arg His 
    210                 215         


<210> 22
<211> 217
<212> PRT
<213> Homo sapiens

<400> 22
His Glu Gly Gly Gln Asp Lys Pro Leu Leu Ser Ala Trp Pro Ser Ala 
1               5                   10                  15      


Val Val Pro Arg Gly Gly His Val Thr Leu Leu Cys Arg Ser Arg Leu 
            20                  25                  30          


Gly Phe Thr Ile Phe Ser Leu Tyr Lys Glu Asp Gly Val Pro Val Pro 
        35                  40                  45              


Glu Leu Tyr Asn Lys Ile Phe Trp Lys Ser Ile Leu Met Gly Pro Val 
    50                  55                  60                  


Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg Gly Ser His Pro Arg 
65                  70                  75                  80  


Ser Pro Ile Glu Trp Ser Ala Pro Ser Asn Pro Leu Val Ile Val Val 
                85                  90                  95      


Thr Gly Leu Phe Gly Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr 
            100                 105                 110         


Val Arg Thr Gly Glu Asn Val Thr Leu Ser Cys Ser Ser Arg Ser Ser 
        115                 120                 125             


Phe Asp Met Tyr His Leu Ser Arg Glu Gly Arg Ala His Glu Pro Arg 
    130                 135                 140                 


Leu Pro Ala Val Pro Ser Val Asp Gly Thr Phe Gln Ala Asp Phe Pro 
145                 150                 155                 160 


Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Thr Cys Phe Ser Ser Leu 
                165                 170                 175     


His Asp Ser Pro Tyr Glu Trp Ser Asp Pro Ser Asp Pro Leu Leu Val 
            180                 185                 190         


Ser Val Thr Gly Asn Ser Ser Ser Ser Ser Ser Ser Pro Thr Glu Pro 
        195                 200                 205             


Ser Ser Lys Thr Gly Ile Arg Arg His 
    210                 215         


<210> 23
<211> 319
<212> PRT
<213> Homo sapiens

<400> 23
His Met Gly Gly Gln Asp Lys Pro Phe Leu Ser Ala Trp Pro Ser Ala 
1               5                   10                  15      


Val Val Pro Arg Gly Gly His Val Thr Leu Arg Cys His Tyr Arg His 
            20                  25                  30          


Arg Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp Arg Ile His Ile Pro 
        35                  40                  45              


Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe Asn Met Ser Pro Val 
    50                  55                  60                  


Thr Thr Ala His Ala Gly Asn Tyr Thr Cys Arg Gly Ser His Pro His 
65                  70                  75                  80  


Ser Pro Thr Gly Trp Ser Ala Pro Ser Asn Pro Val Val Ile Met Val 
                85                  90                  95      


Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala His Pro Gly Pro Leu 
            100                 105                 110         


Val Lys Ser Gly Glu Arg Val Ile Leu Gln Cys Trp Ser Asp Ile Met 
        115                 120                 125             


Phe Glu His Phe Phe Leu His Lys Glu Gly Ile Ser Lys Asp Pro Ser 
    130                 135                 140                 


Arg Leu Val Gly Gln Ile His Asp Gly Val Ser Lys Ala Asn Phe Ser 
145                 150                 155                 160 


Ile Gly Pro Met Met Leu Ala Leu Ala Gly Thr Tyr Arg Cys Tyr Gly 
                165                 170                 175     


Ser Val Thr His Thr Pro Tyr Gln Leu Ser Ala Pro Ser Asp Pro Leu 
            180                 185                 190         


Asp Ile Val Val Thr Gly Pro Tyr Glu Lys Pro Ser Leu Ser Ala Gln 
        195                 200                 205             


Pro Gly Pro Lys Val Gln Ala Gly Glu Ser Val Thr Leu Ser Cys Ser 
    210                 215                 220                 


Ser Arg Ser Ser Tyr Asp Met Tyr His Leu Ser Arg Glu Gly Gly Ala 
225                 230                 235                 240 


His Glu Arg Arg Leu Pro Ala Val Arg Lys Val Asn Arg Thr Phe Gln 
                245                 250                 255     


Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Arg Cys 
            260                 265                 270         


Phe Gly Ser Phe Arg His Ser Pro Tyr Glu Trp Ser Asp Pro Ser Asp 
        275                 280                 285             


Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser Ser Ser Trp Pro Ser 
    290                 295                 300                 


Pro Thr Glu Pro Ser Ser Lys Ser Gly Asn Pro Arg His Leu His 
305                 310                 315                 


<210> 24
<211> 319
<212> PRT
<213> Homo sapiens

<400> 24
Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser Ala Arg Pro Ser Thr 
1               5                   10                  15      


Val Val Pro Arg Gly Gly His Val Ala Leu Gln Cys His Tyr Arg Arg 
            20                  25                  30          


Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp Arg Ser His Val Pro 
        35                  40                  45              


Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe Ile Met Gly Pro Val 
    50                  55                  60                  


Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg Gly Ser Arg Pro His 
65                  70                  75                  80  


Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro Leu Val Ile Met Val 
                85                  90                  95      


Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala His Pro Gly Pro Leu 
            100                 105                 110         


Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys Trp Ser Asp Val Met 
        115                 120                 125             


Phe Glu His Phe Phe Leu His Arg Glu Gly Ile Ser Glu Asp Pro Ser 
    130                 135                 140                 


Arg Leu Val Gly Gln Ile His Asp Gly Val Ser Lys Ala Asn Phe Ser 
145                 150                 155                 160 


Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr Tyr Arg Cys Tyr Gly 
                165                 170                 175     


Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala Pro Ser Asp Pro Leu 
            180                 185                 190         


Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro Ser Leu Ser Ala Gln 
        195                 200                 205             


Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val Thr Leu Ser Cys Ser 
    210                 215                 220                 


Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser Arg Glu Gly Glu Ala 
225                 230                 235                 240 


His Glu Arg Arg Leu Arg Ala Val Pro Lys Val Asn Arg Thr Phe Gln 
                245                 250                 255     


Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Arg Cys 
            260                 265                 270         


Phe Gly Ser Phe Arg Ala Leu Pro Cys Val Trp Ser Asn Ser Ser Asp 
        275                 280                 285             


Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser Ser Ser Trp Pro Ser 
    290                 295                 300                 


Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys Arg His Leu His 
305                 310                 315                 


<210> 25
<211> 297
<212> PRT
<213> Homo sapiens

<400> 25
Gln Asp Lys Pro Phe Leu Ser Ala Trp Pro Gly Thr Val Val Ser Glu 
1               5                   10                  15      


Gly Gln His Val Thr Leu Gln Cys Arg Ser Arg Leu Gly Phe Asn Glu 
            20                  25                  30          


Phe Ser Leu Ser Lys Glu Asp Gly Met Pro Val Pro Glu Leu Tyr Asn 
        35                  40                  45              


Arg Ile Phe Arg Asn Ser Phe Leu Met Gly Pro Val Thr Pro Ala His 
    50                  55                  60                  


Ala Gly Thr Tyr Arg Cys Cys Ser Ser His Pro His Ser Pro Thr Gly 
65                  70                  75                  80  


Trp Ser Ala Pro Ser Asn Pro Val Val Ile Met Val Thr Gly Val His 
                85                  90                  95      


Arg Lys Pro Ser Leu Leu Ala His Pro Gly Pro Leu Val Lys Ser Gly 
            100                 105                 110         


Glu Thr Val Ile Leu Gln Cys Trp Ser Asp Val Arg Phe Glu Arg Phe 
        115                 120                 125             


Leu Leu His Arg Glu Gly Ile Thr Glu Asp Pro Leu Arg Leu Val Gly 
    130                 135                 140                 


Gln Leu His Asp Ala Gly Ser Gln Val Asn Tyr Ser Met Gly Pro Met 
145                 150                 155                 160 


Thr Pro Ala Leu Ala Gly Thr Tyr Arg Cys Phe Gly Ser Val Thr His 
                165                 170                 175     


Leu Pro Tyr Glu Leu Ser Ala Pro Ser Asp Pro Leu Asp Ile Val Val 
            180                 185                 190         


Val Gly Leu Tyr Gly Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr 
        195                 200                 205             


Val Gln Ala Gly Glu Asn Val Thr Leu Ser Cys Ser Ser Arg Ser Leu 
    210                 215                 220                 


Phe Asp Ile Tyr His Leu Ser Arg Glu Ala Glu Ala Gly Glu Leu Arg 
225                 230                 235                 240 


Leu Thr Ala Val Leu Arg Val Asn Gly Thr Phe Gln Ala Asn Phe Pro 
                245                 250                 255     


Leu Gly Pro Val Thr His Gly Gly Asn Tyr Arg Cys Phe Gly Ser Phe 
            260                 265                 270         


Arg Ala Leu Pro His Ala Trp Ser Asp Pro Ser Asp Pro Leu Pro Val 
        275                 280                 285             


Ser Val Thr Gly Asn Ser Arg His Leu 
    290                 295         


<210> 26
<211> 428
<212> PRT
<213> Homo sapiens

<400> 26
Leu Gln Pro Gly Ala Glu Val Pro Val Val Trp Ala Gln Glu Gly Ala 
1               5                   10                  15      


Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser 
            20                  25                  30          


Leu Leu Arg Arg Ala Gly Val Thr Trp Gln His Gln Pro Asp Ser Gly 
        35                  40                  45              


Pro Pro Ala Ala Ala Pro Gly His Pro Leu Ala Pro Gly Pro His Pro 
    50                  55                  60                  


Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu 
65                  70                  75                  80  


Ser Val Gly Pro Gly Gly Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro 
                85                  90                  95      


Arg Val Gln Leu Asp Glu Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu 
            100                 105                 110         


Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala Gly Glu Tyr Arg Ala Ala 
        115                 120                 125             


Val His Leu Arg Asp Arg Ala Leu Ser Cys Arg Leu Arg Leu Arg Leu 
    130                 135                 140                 


Gly Gln Ala Ser Met Thr Ala Ser Pro Pro Gly Ser Leu Arg Ala Ser 
145                 150                 155                 160 


Asp Trp Val Ile Leu Asn Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala 
                165                 170                 175     


Ser Val His Trp Phe Arg Asn Arg Gly Gln Gly Arg Val Pro Val Arg 
            180                 185                 190         


Glu Ser Pro His His His Leu Ala Glu Ser Phe Leu Phe Leu Pro Gln 
        195                 200                 205             


Val Ser Pro Met Asp Ser Gly Pro Trp Gly Cys Ile Leu Thr Tyr Arg 
    210                 215                 220                 


Asp Gly Phe Asn Val Ser Ile Met Tyr Asn Leu Thr Val Leu Gly Leu 
225                 230                 235                 240 


Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala Gly Ala Gly Ser Arg Val 
                245                 250                 255     


Gly Leu Pro Cys Arg Leu Pro Ala Gly Val Gly Thr Arg Ser Phe Leu 
            260                 265                 270         


Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly Pro Asp Leu Leu Val Thr 
        275                 280                 285             


Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu Glu Asp Val Ser Gln Ala 
    290                 295                 300                 


Gln Ala Gly Thr Tyr Thr Cys His Ile His Leu Gln Glu Gln Gln Leu 
305                 310                 315                 320 


Asn Ala Thr Val Thr Leu Ala Ile Ile Thr Val Thr Pro Lys Ser Phe 
                325                 330                 335     


Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu Cys Glu Val Thr Pro Val 
            340                 345                 350         


Ser Gly Gln Glu Arg Phe Val Trp Ser Ser Leu Asp Thr Pro Ser Gln 
        355                 360                 365             


Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala Gln Glu Ala Gln Leu Leu 
    370                 375                 380                 


Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln Gly Glu Arg Leu Leu Gly 
385                 390                 395                 400 


Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser Pro Gly Ala Gln Arg Ser 
                405                 410                 415     


Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly His Leu 
            420                 425             


<210> 27
<211> 438
<212> PRT
<213> Homo sapiens

<400> 27
Gly His Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser Val Ile 
1               5                   10                  15      


Thr Gln Gly Ser Pro Val Thr Leu Arg Cys Gln Gly Gly Gln Glu Thr 
            20                  25                  30          


Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Thr Ala Leu Trp Ile Thr 
        35                  40                  45              


Arg Ile Pro Gln Glu Leu Val Lys Lys Gly Gln Phe Pro Ile Pro Ser 
    50                  55                  60                  


Ile Thr Trp Glu His Ala Gly Arg Tyr Arg Cys Tyr Tyr Gly Ser Asp 
65                  70                  75                  80  


Thr Ala Gly Arg Ser Glu Ser Ser Asp Pro Leu Glu Leu Val Val Thr 
                85                  90                  95      


Gly Ala Tyr Ile Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val Val 
            100                 105                 110         


Asn Ser Gly Gly Asn Val Ile Leu Gln Cys Asp Ser Gln Val Ala Phe 
        115                 120                 125             


Asp Gly Phe Ser Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln Cys 
    130                 135                 140                 


Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe Ser 
145                 150                 155                 160 


Val Gly Pro Val Ser Pro Ser Arg Arg Trp Trp Tyr Arg Cys Tyr Ala 
                165                 170                 175     


Tyr Asp Ser Asn Ser Pro Tyr Glu Trp Ser Leu Pro Ser Asp Leu Leu 
            180                 185                 190         


Glu Leu Leu Val Leu Gly Val Ser Lys Lys Pro Ser Leu Ser Val Gln 
        195                 200                 205             


Pro Gly Pro Ile Val Ala Pro Glu Glu Thr Leu Thr Leu Gln Cys Gly 
    210                 215                 220                 


Ser Asp Ala Gly Tyr Asn Arg Phe Val Leu Tyr Lys Asp Gly Glu Arg 
225                 230                 235                 240 


Asp Phe Leu Gln Leu Ala Gly Ala Gln Pro Gln Ala Gly Leu Ser Gln 
                245                 250                 255     


Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln Tyr 
            260                 265                 270         


Arg Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Trp Ser Ala Pro Ser 
        275                 280                 285             


Asp Pro Leu Asp Ile Leu Ile Ala Gly Gln Phe Tyr Asp Arg Val Ser 
    290                 295                 300                 


Leu Ser Val Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val Thr 
305                 310                 315                 320 


Leu Leu Cys Gln Ser Gln Gly Trp Met Gln Thr Phe Leu Leu Thr Lys 
                325                 330                 335     


Glu Gly Ala Ala Asp Asp Pro Trp Arg Leu Arg Ser Thr Tyr Gln Ser 
            340                 345                 350         


Gln Lys Tyr Gln Ala Glu Phe Pro Met Gly Pro Val Thr Ser Ala His 
        355                 360                 365             


Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu 
    370                 375                 380                 


Leu Thr His Pro Ser Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser 
385                 390                 395                 400 


Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro 
                405                 410                 415     


Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu 
            420                 425                 430         


Gly Arg His Leu Gly Val 
        435             


<210> 28
<211> 440
<212> PRT
<213> Homo sapiens

<400> 28
Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser 
1               5                   10                  15      


Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu 
            20                  25                  30          


Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp 
        35                  40                  45              


Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile 
    50                  55                  60                  


Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr 
65                  70                  75                  80  


Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met 
                85                  90                  95      


Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val 
            100                 105                 110         


Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala 
        115                 120                 125             


Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Glu Glu His Pro Gln 
    130                 135                 140                 


Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe 
145                 150                 155                 160 


Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr 
                165                 170                 175     


Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu 
            180                 185                 190         


Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Leu Ser Val 
        195                 200                 205             


Gln Pro Gly Pro Val Val Ala Pro Gly Glu Ser Leu Thr Leu Gln Cys 
    210                 215                 220                 


Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr Lys Glu Gly Glu 
225                 230                 235                 240 


Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro Gln Ala Gly Leu Ser 
                245                 250                 255     


Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln 
            260                 265                 270         


Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Cys Ser Ala Pro 
        275                 280                 285             


Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln Ile Arg Gly Thr Pro 
    290                 295                 300                 


Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val 
305                 310                 315                 320 


Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His Thr Phe Leu Leu Thr 
                325                 330                 335     


Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu Arg Ser Ile His Glu 
            340                 345                 350         


Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Ala 
        355                 360                 365             


His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu Asn Ser Asp Pro Tyr 
    370                 375                 380                 


Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu Val Val Ser Gly Pro 
385                 390                 395                 400 


Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro Ile Ser Thr Pro Ala 
                405                 410                 415     


Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser 
            420                 425                 430         


Gly Leu Gly Arg His Leu Gly Val 
        435                 440 


<210> 29
<211> 420
<212> PRT
<213> Homo sapiens

<400> 29
Gly Pro Phe Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser Val Ile 
1               5                   10                  15      


Ser Trp Gly Ser Pro Val Thr Ile Trp Cys Gln Gly Ser Gln Glu Ala 
            20                  25                  30          


Gln Glu Tyr Arg Leu His Lys Glu Gly Ser Pro Glu Pro Leu Asp Arg 
        35                  40                  45              


Asn Asn Pro Leu Glu Pro Lys Asn Lys Ala Arg Phe Ser Ile Pro Ser 
    50                  55                  60                  


Met Thr Glu His His Ala Gly Arg Tyr Arg Cys His Tyr Tyr Ser Ser 
65                  70                  75                  80  


Ala Gly Trp Ser Glu Pro Ser Asp Pro Leu Glu Met Val Met Thr Gly 
                85                  90                  95      


Ala Tyr Ser Lys Pro Thr Leu Ser Ala Leu Pro Ser Pro Val Val Ala 
            100                 105                 110         


Ser Gly Gly Asn Met Thr Leu Arg Cys Gly Ser Gln Lys Gly Tyr His 
        115                 120                 125             


His Phe Val Leu Met Lys Glu Gly Glu His Gln Leu Pro Arg Thr Leu 
    130                 135                 140                 


Asp Ser Gln Gln Leu His Ser Arg Gly Phe Gln Ala Leu Phe Pro Val 
145                 150                 155                 160 


Gly Pro Val Thr Pro Ser His Arg Trp Arg Phe Thr Cys Tyr Tyr Tyr 
                165                 170                 175     


Tyr Thr Asn Thr Pro Trp Val Trp Ser His Pro Ser Asp Pro Leu Glu 
            180                 185                 190         


Ile Leu Pro Ser Gly Val Ser Arg Lys Pro Ser Leu Leu Thr Leu Gln 
        195                 200                 205             


Gly Pro Val Leu Ala Pro Gly Gln Ser Leu Thr Leu Gln Cys Gly Ser 
    210                 215                 220                 


Asp Val Gly Tyr Asn Arg Phe Val Leu Tyr Lys Glu Gly Glu Arg Asp 
225                 230                 235                 240 


Phe Leu Gln Arg Pro Gly Gln Gln Pro Gln Ala Gly Leu Ser Gln Ala 
                245                 250                 255     


Asn Phe Thr Leu Gly Pro Val Ser Pro Ser Asn Gly Gly Gln Tyr Arg 
            260                 265                 270         


Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Trp Ser Ala Pro Ser Asp 
        275                 280                 285             


Pro Leu Asn Ile Leu Met Ala Gly Gln Ile Tyr Asp Thr Val Ser Leu 
    290                 295                 300                 


Ser Ala Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val Thr Leu 
305                 310                 315                 320 


Leu Cys Gln Ser Trp Trp Gln Phe Asp Thr Phe Leu Leu Thr Lys Glu 
                325                 330                 335     


Gly Ala Ala His Pro Pro Leu Arg Leu Arg Ser Met Tyr Gly Ala His 
            340                 345                 350         


Lys Tyr Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Ala His Ala 
        355                 360                 365             


Gly Thr Tyr Arg Cys Tyr Gly Ser Tyr Ser Ser Asn Pro His Leu Leu 
    370                 375                 380                 


Ser His Pro Ser Glu Pro Leu Glu Leu Val Val Ser Gly His Ser Gly 
385                 390                 395                 400 


Gly Ser Ser Leu Pro Pro Thr Gly Pro Pro Ser Thr Pro Gly Leu Gly 
                405                 410                 415     


Arg Tyr Leu Glu 
            420 


<210> 30
<211> 238
<212> PRT
<213> Homo sapiens

<400> 30
Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Trp Gly Asn Ser Val Thr Ile Trp Cys Gln Gly Thr Leu 
            20                  25                  30          


Glu Ala Arg Glu Tyr Arg Leu Asp Lys Glu Glu Ser Pro Ala Pro Trp 
        35                  40                  45              


Asp Arg Gln Asn Pro Leu Glu Pro Lys Asn Lys Ala Arg Phe Ser Ile 
    50                  55                  60                  


Pro Ser Met Thr Glu Asp Tyr Ala Gly Arg Tyr Arg Cys Tyr Tyr Arg 
65                  70                  75                  80  


Ser Pro Val Gly Trp Ser Gln Pro Ser Asp Pro Leu Glu Leu Val Met 
                85                  90                  95      


Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala Leu Pro Ser Pro Leu 
            100                 105                 110         


Val Thr Ser Gly Lys Ser Val Thr Leu Leu Cys Gln Ser Arg Ser Pro 
        115                 120                 125             


Met Asp Thr Phe Leu Leu Ile Lys Glu Arg Ala Ala His Pro Leu Leu 
    130                 135                 140                 


His Leu Arg Ser Glu His Gly Ala Gln Gln His Gln Ala Glu Phe Pro 
145                 150                 155                 160 


Met Ser Pro Val Thr Ser Val His Gly Gly Thr Tyr Arg Cys Phe Ser 
                165                 170                 175     


Ser His Gly Phe Ser His Tyr Leu Leu Ser His Pro Ser Asp Pro Leu 
            180                 185                 190         


Glu Leu Ile Val Ser Gly Ser Leu Glu Asp Pro Arg Pro Ser Pro Thr 
        195                 200                 205             


Arg Ser Val Ser Thr Ala Ala Gly Pro Glu Asp Gln Pro Leu Met Pro 
    210                 215                 220                 


Thr Gly Ser Val Pro His Ser Gly Leu Arg Arg His Trp Glu 
225                 230                 235             


<210> 31
<211> 435
<212> PRT
<213> Homo sapiens

<400> 31
Gly Thr Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Ala Ser Val Ile 
1               5                   10                  15      


Ala Arg Gly Lys Pro Val Thr Leu Trp Cys Gln Gly Pro Leu Glu Thr 
            20                  25                  30          


Glu Glu Tyr Arg Leu Asp Lys Glu Gly Leu Pro Trp Ala Arg Lys Arg 
        35                  40                  45              


Gln Asn Pro Leu Glu Pro Gly Ala Lys Ala Lys Phe His Ile Pro Ser 
    50                  55                  60                  


Thr Val Tyr Asp Ser Ala Gly Arg Tyr Arg Cys Tyr Tyr Glu Thr Pro 
65                  70                  75                  80  


Ala Gly Trp Ser Glu Pro Ser Asp Pro Leu Glu Leu Val Ala Thr Gly 
                85                  90                  95      


Phe Tyr Ala Glu Pro Thr Leu Leu Ala Leu Pro Ser Pro Val Val Ala 
            100                 105                 110         


Ser Gly Gly Asn Val Thr Leu Gln Cys Asp Thr Leu Asp Gly Leu Leu 
        115                 120                 125             


Thr Phe Val Leu Val Glu Glu Glu Gln Lys Leu Pro Arg Thr Leu Tyr 
    130                 135                 140                 


Ser Gln Lys Leu Pro Lys Gly Pro Ser Gln Ala Leu Phe Pro Val Gly 
145                 150                 155                 160 


Pro Val Thr Pro Ser Cys Arg Trp Arg Phe Arg Cys Tyr Tyr Tyr Tyr 
                165                 170                 175     


Arg Lys Asn Pro Gln Val Trp Ser Asn Pro Ser Asp Leu Leu Glu Ile 
            180                 185                 190         


Leu Val Pro Gly Val Ser Arg Lys Pro Ser Leu Leu Ile Pro Gln Gly 
        195                 200                 205             


Ser Val Val Ala Arg Gly Gly Ser Leu Thr Leu Gln Cys Arg Ser Asp 
    210                 215                 220                 


Val Gly Tyr Asp Ile Phe Val Leu Tyr Lys Glu Gly Glu His Asp Leu 
225                 230                 235                 240 


Val Gln Gly Ser Gly Gln Gln Pro Gln Ala Gly Leu Ser Gln Ala Asn 
                245                 250                 255     


Phe Thr Leu Gly Pro Val Ser Arg Ser His Gly Gly Gln Tyr Arg Cys 
            260                 265                 270         


Tyr Gly Ala His Asn Leu Ser Pro Arg Trp Ser Ala Pro Ser Asp Pro 
        275                 280                 285             


Leu Asp Ile Leu Ile Ala Gly Leu Ile Pro Asp Ile Pro Ala Leu Ser 
    290                 295                 300                 


Val Gln Pro Gly Pro Lys Val Ala Ser Gly Glu Asn Val Thr Leu Leu 
305                 310                 315                 320 


Cys Gln Ser Trp His Gln Ile Asp Thr Phe Phe Leu Thr Lys Glu Gly 
                325                 330                 335     


Ala Ala His Pro Pro Leu Cys Leu Lys Ser Lys Tyr Gln Ser Tyr Arg 
            340                 345                 350         


His Gln Ala Glu Phe Ser Met Ser Pro Val Thr Ser Ala Gln Gly Gly 
        355                 360                 365             


Thr Tyr Arg Cys Tyr Ser Ala Ile Arg Ser Tyr Pro Tyr Leu Leu Ser 
    370                 375                 380                 


Ser Pro Ser Tyr Pro Gln Glu Leu Val Val Ser Gly Pro Ser Gly Asp 
385                 390                 395                 400 


Pro Ser Leu Ser Pro Thr Gly Ser Thr Pro Thr Pro Gly Pro Glu Asp 
                405                 410                 415     


Gln Pro Leu Thr Pro Thr Gly Leu Asp Pro Gln Ser Gly Leu Gly Arg 
            420                 425                 430         


His Leu Gly 
        435 


<210> 32
<211> 118
<212> PRT
<213> Homo sapiens

<400> 32
Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser 
1               5                   10                  15      


Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala 
            20                  25                  30          


Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu 
        35                  40                  45              


Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala 
    50                  55                  60                  


Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp 
65                  70                  75                  80  


Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu 
                85                  90                  95      


Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys 
            100                 105                 110         


Glu His Pro Gln Leu Gly 
        115             


<210> 33
<211> 147
<212> PRT
<213> Homo sapiens

<400> 33
Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser 
        35                  40                  45              


Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140                 


Thr Leu Val 
145         


<210> 34
<211> 534
<212> PRT
<213> Homo sapiens

<400> 34
Met Asp Gly Arg Phe Trp Ile Arg Val Gln Glu Ser Val Met Val Pro 
1               5                   10                  15      


Glu Gly Leu Cys Ile Ser Val Pro Cys Ser Phe Ser Tyr Pro Arg Gln 
            20                  25                  30          


Asp Trp Thr Gly Ser Thr Pro Ala Tyr Gly Tyr Trp Phe Lys Ala Val 
        35                  40                  45              


Thr Glu Thr Thr Lys Gly Ala Pro Val Ala Thr Asn His Gln Ser Arg 
    50                  55                  60                  


Glu Val Glu Met Ser Thr Arg Gly Arg Phe Gln Leu Thr Gly Asp Pro 
65                  70                  75                  80  


Ala Lys Gly Asn Cys Ser Leu Val Ile Arg Asp Ala Gln Met Gln Asp 
                85                  90                  95      


Glu Ser Gln Tyr Phe Phe Arg Val Glu Arg Gly Ser Tyr Val Arg Tyr 
            100                 105                 110         


Asn Phe Met Asn Asp Gly Phe Phe Leu Lys Val Thr Ala Leu Thr Gln 
        115                 120                 125             


Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val 
    130                 135                 140                 


Thr Val Ile Cys Val Phe Asn Trp Ala Phe Glu Glu Cys Pro Pro Pro 
145                 150                 155                 160 


Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Ser Gln Gly Thr Lys Pro 
                165                 170                 175     


Thr Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Arg Pro Gln Asp 
            180                 185                 190         


His Asn Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val 
        195                 200                 205             


Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Arg Asp 
    210                 215                 220                 


Leu Val Ile Ser Ile Ser Arg Asp Asn Thr Pro Ala Leu Glu Pro Gln 
225                 230                 235                 240 


Pro Gln Gly Asn Val Pro Tyr Leu Glu Ala Gln Lys Gly Gln Phe Leu 
                245                 250                 255     


Arg Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp 
            260                 265                 270         


Val Leu Gln Asn Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg 
        275                 280                 285             


Pro Leu Gly Leu Glu Leu Pro Gly Val Lys Ala Gly Asp Ser Gly Arg 
    290                 295                 300                 


Tyr Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu 
305                 310                 315                 320 


Asp Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser 
                325                 330                 335     


Gln Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu 
            340                 345                 350         


Pro Val Leu Glu Gly Gln Ser Leu Cys Leu Val Cys Val Thr His Ser 
        355                 360                 365             


Ser Pro Pro Ala Arg Leu Ser Trp Thr Gln Arg Gly Gln Val Leu Ser 
    370                 375                 380                 


Pro Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Arg Val Gln 
385                 390                 395                 400 


Val Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His Pro Leu Gly 
                405                 410                 415     


Ser Gln His Val Ser Leu Ser Leu Ser Val His Tyr Ser Pro Lys Leu 
            420                 425                 430         


Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys 
        435                 440                 445             


Ser Ser Gln Ala Ser Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu 
    450                 455                 460                 


Glu Leu Leu Glu Gly Asn Ser Ser Gln Asp Ser Phe Glu Val Thr Pro 
465                 470                 475                 480 


Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly 
                485                 490                 495     


Leu Ser Ser Gly Leu Arg Leu Arg Cys Glu Ala Trp Asn Val His Gly 
            500                 505                 510         


Ala Gln Ser Gly Ser Ile Leu Gln Leu Pro Asp Lys Lys Gly Leu Ile 
        515                 520                 525             


Ser Thr Ala Phe Ser Asn 
    530                 


<210> 35
<211> 335
<212> PRT
<213> Homo sapiens

<400> 35
Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser Ser Val 
1               5                   10                  15      


Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe Ser Tyr 
            20                  25                  30          


Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr Trp Phe 
        35                  40                  45              


Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr Asn Asn 
    50                  55                  60                  


Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu 
65                  70                  75                  80  


Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg 
                85                  90                  95      


Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Asn Ile 
            100                 105                 110         


Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala Leu 
        115                 120                 125             


Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys 
    130                 135                 140                 


Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr 
145                 150                 155                 160 


Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu His Pro 
                165                 170                 175     


Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln His 
            180                 185                 190         


His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala Gly Val 
        195                 200                 205             


Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro Pro Gln Asn 
    210                 215                 220                 


Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser Thr Ala Leu 
225                 230                 235                 240 


Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser Leu Arg Leu 
                245                 250                 255     


Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp Thr Trp 
            260                 265                 270         


Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Leu Val Leu 
        275                 280                 285             


Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr Cys Arg Ala 
    290                 295                 300                 


Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu Ser Leu Gln 
305                 310                 315                 320 


Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu Leu 
                325                 330                 335 


<210> 36
<211> 331
<212> PRT
<213> Homo sapiens

<400> 36
Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
    210                 215                 220                 


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
                245                 250                 255     


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
            260                 265                 270         


Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
        275                 280                 285             


Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg 
    290                 295                 300                 


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
305                 310                 315                 320 


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly 
                325                 330     


<210> 37
<211> 498
<212> PRT
<213> Homo sapiens

<400> 37
Val Trp Glu Lys Thr Val Asn Thr Glu Glu Asn Val Tyr Ala Thr Leu 
1               5                   10                  15      


Gly Ser Asp Val Asn Leu Thr Cys Gln Thr Gln Thr Val Gly Phe Phe 
            20                  25                  30          


Val Gln Met Gln Trp Ser Lys Val Thr Asn Lys Ile Asp Leu Ile Ala 
        35                  40                  45              


Val Tyr His Pro Gln Tyr Gly Phe Tyr Cys Ala Tyr Gly Arg Pro Cys 
    50                  55                  60                  


Glu Ser Leu Val Thr Phe Thr Glu Thr Pro Glu Asn Gly Ser Lys Trp 
65                  70                  75                  80  


Thr Leu His Leu Arg Asn Met Ser Cys Ser Val Ser Gly Arg Tyr Glu 
                85                  90                  95      


Cys Met Leu Val Leu Tyr Pro Glu Gly Ile Gln Thr Lys Ile Tyr Asn 
            100                 105                 110         


Leu Leu Ile Gln Thr His Val Thr Ala Asp Glu Trp Asn Ser Asn His 
        115                 120                 125             


Thr Ile Glu Ile Glu Ile Asn Gln Thr Leu Glu Ile Pro Cys Phe Gln 
    130                 135                 140                 


Asn Ser Ser Ser Lys Ile Ser Ser Glu Phe Thr Tyr Ala Trp Ser Val 
145                 150                 155                 160 


Glu Asn Ser Ser Thr Asp Ser Trp Val Leu Leu Ser Lys Gly Ile Lys 
                165                 170                 175     


Glu Asp Asn Gly Thr Gln Glu Thr Leu Ile Ser Gln Asn His Leu Ile 
            180                 185                 190         


Ser Asn Ser Thr Leu Leu Lys Asp Arg Val Lys Leu Gly Thr Asp Tyr 
        195                 200                 205             


Arg Leu His Leu Ser Pro Val Gln Ile Phe Asp Asp Gly Arg Lys Phe 
    210                 215                 220                 


Ser Cys His Ile Arg Val Gly Pro Asn Lys Ile Leu Arg Ser Ser Thr 
225                 230                 235                 240 


Thr Val Lys Val Phe Ala Lys Pro Glu Ile Pro Val Ile Val Glu Asn 
                245                 250                 255     


Asn Ser Thr Asp Val Leu Val Glu Arg Arg Phe Thr Cys Leu Leu Lys 
            260                 265                 270         


Asn Val Phe Pro Lys Ala Asn Ile Thr Trp Phe Ile Asp Gly Ser Phe 
        275                 280                 285             


Leu His Asp Glu Lys Glu Gly Ile Tyr Ile Thr Asn Glu Glu Arg Lys 
    290                 295                 300                 


Gly Lys Asp Gly Phe Leu Glu Leu Lys Ser Val Leu Thr Arg Val His 
305                 310                 315                 320 


Ser Asn Lys Pro Ala Gln Ser Asp Asn Leu Thr Ile Trp Cys Met Ala 
                325                 330                 335     


Leu Ser Pro Val Pro Gly Asn Lys Val Trp Asn Ile Ser Ser Glu Lys 
            340                 345                 350         


Ile Thr Phe Leu Leu Gly Ser Glu Ile Ser Ser Thr Asp Pro Pro Leu 
        355                 360                 365             


Ser Val Thr Glu Ser Thr Leu Asp Thr Gln Pro Ser Pro Ala Ser Ser 
    370                 375                 380                 


Val Ser Pro Ala Arg Tyr Pro Ala Thr Ser Ser Val Thr Leu Val Asp 
385                 390                 395                 400 


Val Ser Ala Leu Arg Pro Asn Thr Thr Pro Gln Pro Ser Asn Ser Ser 
                405                 410                 415     


Met Thr Thr Arg Gly Phe Asn Tyr Pro Trp Thr Ser Ser Gly Thr Asp 
            420                 425                 430         


Thr Lys Lys Ser Val Ser Arg Ile Pro Ser Glu Thr Tyr Ser Ser Ser 
        435                 440                 445             


Pro Ser Gly Ala Gly Ser Thr Leu His Asp Asn Val Phe Thr Ser Thr 
    450                 455                 460                 


Ala Arg Ala Phe Ser Glu Val Pro Thr Thr Ala Asn Gly Ser Thr Lys 
465                 470                 475                 480 


Thr Asn His Val His Ile Thr Gly Ile Val Val Asn Lys Pro Lys Asp 
                485                 490                 495     


Gly Met 
        


<210> 38
<211> 93
<212> PRT
<213> Homo sapiens

<400> 38
Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Val 
1               5                   10                  15      


Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val 
            20                  25                  30          


Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp 
        35                  40                  45              


Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr Thr 
    50                  55                  60                  


Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro Thr 
65                  70                  75                  80  


Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu 
                85                  90              


<210> 39
<211> 144
<212> PRT
<213> Homo sapiens

<400> 39
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


<210> 40
<211> 120
<212> PRT
<213> Homo sapiens

<400> 40
Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
1               5                   10                  15      


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
            20                  25                  30          


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
        35                  40                  45              


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
    50                  55                  60                  


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
65                  70                  75                  80  


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr 
                85                  90                  95      


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
            100                 105                 110         


His Gly Ala Arg Phe Gln Ile Pro 
        115                 120 


<210> 41
<211> 181
<212> PRT
<213> Homo sapiens

<400> 41
Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro 
1               5                   10                  15      


Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp 
            20                  25                  30          


Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg 
        35                  40                  45              


Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn 
    50                  55                  60                  


Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr 
65                  70                  75                  80  


Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile 
                85                  90                  95      


Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys 
            100                 105                 110         


Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro 
        115                 120                 125             


Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu 
    130                 135                 140                 


Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn 
145                 150                 155                 160 


Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala 
                165                 170                 175     


Thr Ile Arg Ile Gly 
            180     


<210> 42
<211> 10
<212> PRT
<213> Homo sapiens

<400> 42
Met Ala Val Phe Lys Thr Thr Leu Trp Arg 
1               5                   10  


<210> 43
<211> 45
<212> PRT
<213> Homo sapiens

<400> 43
Met Asp Gln Gln Ala Ile Tyr Ala Glu Leu Asn Leu Pro Thr Asp Ser 
1               5                   10                  15      


Gly Pro Glu Ser Ser Ser Pro Ser Ser Leu Pro Arg Asp Val Cys Gln 
            20                  25                  30          


Gly Ser Pro Trp His Gln Phe Ala Leu Lys Leu Ser Cys 
        35                  40                  45  


<210> 44
<211> 38
<212> PRT
<213> Homo sapiens

<400> 44
Met Thr Asp Ser Val Ile Tyr Ser Met Leu Glu Leu Pro Thr Ala Thr 
1               5                   10                  15      


Gln Ala Gln Asn Asp Tyr Gly Pro Gln Gln Lys Ser Ser Ser Ser Arg 
            20                  25                  30          


Pro Ser Cys Ser Cys Leu 
        35              


<210> 45
<211> 70
<212> PRT
<213> Homo sapiens

<400> 45
Met Asp Asn Gln Gly Val Ile Tyr Ser Asp Leu Asn Leu Pro Pro Asn 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Pro Lys Gly Asn Lys Asn Ser Ile Leu 
            20                  25                  30          


Ala Thr Glu Gln Glu Ile Thr Tyr Ala Glu Leu Asn Leu Gln Lys Ala 
        35                  40                  45              


Ser Gln Asp Phe Gln Gly Asn Asp Lys Thr Tyr His Cys Lys Asp Leu 
    50                  55                  60                  


Pro Ser Ala Pro Glu Lys 
65                  70  


<210> 46
<211> 144
<212> PRT
<213> Homo sapiens

<400> 46
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


<210> 47
<211> 93
<212> PRT
<213> Homo sapiens

<400> 47
Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Val 
1               5                   10                  15      


Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val 
            20                  25                  30          


Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp 
        35                  40                  45              


Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr Thr 
    50                  55                  60                  


Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro Thr 
65                  70                  75                  80  


Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu 
                85                  90              


<210> 48
<211> 24
<212> PRT
<213> Homo sapiens

<400> 48
Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
1               5                   10                  15      


Tyr Ile Asn Met Pro Gly Arg Gly 
            20                  


<210> 49
<211> 126
<212> PRT
<213> Homo sapiens

<400> 49
His Trp Lys His Arg Val Ala Thr Arg Phe Thr Leu Pro Arg Phe Leu 
1               5                   10                  15      


Gln Arg Arg Ser Ser Arg Arg Lys Val Cys Thr Lys Thr Phe Leu Gly 
            20                  25                  30          


Pro Arg Ile Ile Gly Leu Arg His Glu Ile Ser Val Glu Thr Gln Asp 
        35                  40                  45              


His Lys Ser Ala Val Arg Gly Asn Asn Thr His Asp Asn Tyr Glu Asn 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Lys Ala Lys Gly Lys Thr Asp Lys Glu Leu 
65                  70                  75                  80  


Tyr Glu Asn Thr Gly Gln Ser Asn Phe Glu Glu His Ile Tyr Gly Asn 
                85                  90                  95      


Glu Thr Ser Ser Asp Tyr Tyr Asn Phe Gln Lys Pro Arg Pro Ser Glu 
            100                 105                 110         


Val Pro Gln Asp Glu Asp Ile Tyr Ile Leu Pro Asp Ser Tyr 
        115                 120                 125     


<210> 50
<211> 52
<212> PRT
<213> Homo sapiens

<400> 50
Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala 
1               5                   10                  15      


Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu 
            20                  25                  30          


Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg 
        35                  40                  45              


Pro Tyr Tyr Lys 
    50          


<210> 51
<211> 42
<212> PRT
<213> Homo sapiens

<400> 51
Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys 
1               5                   10                  15      


Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr 
            20                  25                  30          


Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
        35                  40          


<210> 52
<211> 61
<212> PRT
<213> Homo sapiens

<400> 52
Arg Lys Glu Leu Lys Arg Lys Lys Lys Trp Asp Leu Glu Ile Ser Leu 
1               5                   10                  15      


Asp Ser Gly His Glu Lys Lys Val Ile Ser Ser Leu Gln Glu Asp Arg 
            20                  25                  30          


His Leu Glu Glu Glu Leu Lys Cys Gln Glu Gln Lys Glu Glu Gln Leu 
        35                  40                  45              


Gln Glu Gly Val His Arg Lys Glu Pro Gln Gly Ala Thr 
    50                  55                  60      


<210> 53
<211> 77
<212> PRT
<213> Homo sapiens

<400> 53
Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
1               5                   10                  15      


Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
            20                  25                  30          


Gln Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
        35                  40                  45              


Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
    50                  55                  60                  


Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
65                  70                  75          


<210> 54
<211> 77
<212> PRT
<213> Homo sapiens

<400> 54
Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
1               5                   10                  15      


Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
            20                  25                  30          


Gln Pro Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
        35                  40                  45              


Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
    50                  55                  60                  


Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
65                  70                  75          


<210> 55
<211> 25
<212> PRT
<213> Homo sapiens

<400> 55
Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe 
1               5                   10                  15      


Lys Trp Arg Lys Asp Pro Gln Asp Lys 
            20                  25  


<210> 56
<211> 41
<212> PRT
<213> Homo sapiens

<400> 56
Glu Asn Trp His Ser His Thr Ala Leu Asn Lys Glu Ala Ser Ala Asp 
1               5                   10                  15      


Val Ala Glu Pro Ser Trp Ser Gln Gln Met Cys Gln Pro Gly Leu Thr 
            20                  25                  30          


Phe Ala Arg Thr Pro Ser Val Cys Lys 
        35                  40      


<210> 57
<211> 12
<212> PRT
<213> Homo sapiens

<400> 57
Lys Cys Asp Arg Lys Pro Asp Arg Thr Asn Ser Asn 
1               5                   10          


<210> 58
<211> 120
<212> PRT
<213> Homo sapiens

<400> 58
Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu 
1               5                   10                  15      


Phe Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu Lys Thr Arg Arg Asn 
            20                  25                  30          


His Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser 
        35                  40                  45              


Met Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr 
    50                  55                  60                  


Thr Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys 
65                  70                  75                  80  


Arg Asn His Ser Pro Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly 
                85                  90                  95      


Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu 
            100                 105                 110         


Leu Glu Asn Phe Asp Val Tyr Ser 
        115                 120 


<210> 59
<211> 77
<212> PRT
<213> Homo sapiens

<400> 59
Gln Leu Arg Arg Arg Gly Lys Thr Asn His Tyr Gln Thr Thr Val Glu 
1               5                   10                  15      


Lys Lys Ser Leu Thr Ile Tyr Ala Gln Val Gln Lys Pro Gly Pro Leu 
            20                  25                  30          


Gln Lys Lys Leu Asp Ser Phe Pro Ala Gln Asp Pro Cys Thr Thr Ile 
        35                  40                  45              


Tyr Val Ala Ala Thr Glu Pro Val Pro Glu Ser Val Gln Glu Thr Asn 
    50                  55                  60                  


Ser Ile Thr Val Tyr Ala Ser Val Thr Leu Pro Glu Ser 
65                  70                  75          


<210> 60
<211> 99
<212> PRT
<213> Homo sapiens

<400> 60
Arg Leu Phe Lys Arg Arg Gln Gly Arg Ile Phe Pro Glu Gly Ser Cys 
1               5                   10                  15      


Leu Asn Thr Phe Thr Lys Asn Pro Tyr Ala Ala Ser Lys Lys Thr Ile 
            20                  25                  30          


Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr Gln Pro Ala Glu Ser Arg 
        35                  40                  45              


Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val Leu Pro Ser Lys Glu Glu 
    50                  55                  60                  


Pro Val Asn Thr Val Tyr Ser Glu Val Gln Phe Ala Asp Lys Met Gly 
65                  70                  75                  80  


Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro Gly Thr Ser Ser Tyr Glu 
                85                  90                  95      


Ile Val Ile 
            


<210> 61
<211> 84
<212> PRT
<213> Homo sapiens

<400> 61
Leu Arg Lys Arg Arg Asp Ser Leu Ser Leu Ser Thr Gln Arg Thr Gln 
1               5                   10                  15      


Gly Pro Ala Glu Ser Ala Arg Asn Leu Glu Tyr Val Ser Val Ser Pro 
            20                  25                  30          


Thr Asn Asn Thr Val Tyr Ala Ser Val Thr His Ser Asn Arg Glu Thr 
        35                  40                  45              


Glu Ile Trp Thr Pro Arg Glu Asn Asp Thr Ile Thr Ile Tyr Ser Thr 
    50                  55                  60                  


Ile Asn His Ser Lys Glu Ser Lys Pro Thr Phe Ser Arg Ala Thr Ala 
65                  70                  75                  80  


Leu Asp Asn Val 
                


<210> 62
<211> 88
<212> PRT
<213> Homo sapiens

<400> 62
Trp Phe Leu Lys Arg Glu Arg Gln Glu Glu Tyr Ile Glu Glu Lys Lys 
1               5                   10                  15      


Arg Val Asp Ile Cys Arg Glu Thr Pro Asn Ile Cys Pro His Ser Gly 
            20                  25                  30          


Glu Asn Thr Glu Tyr Asp Thr Ile Pro His Thr Asn Arg Thr Ile Leu 
        35                  40                  45              


Lys Glu Asp Pro Ala Asn Thr Val Tyr Ser Thr Val Glu Ile Pro Lys 
    50                  55                  60                  


Lys Met Glu Asn Pro His Ser Leu Leu Thr Met Pro Asp Thr Pro Arg 
65                  70                  75                  80  


Leu Phe Ala Tyr Glu Asn Val Ile 
                85              


<210> 63
<211> 116
<212> PRT
<213> Homo sapiens

<400> 63
Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr 
1               5                   10                  15      


Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln 
            20                  25                  30          


Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro 
        35                  40                  45              


Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro 
    50                  55                  60                  


Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro 
                85                  90                  95      


Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser 
            100                 105                 110         


Pro Ser Ser Asn 
        115     


<210> 64
<211> 179
<212> PRT
<213> Homo sapiens

<400> 64
Lys Arg Lys Gly Arg Cys Ser Val Pro Ala Phe Cys Ser Ser Gln Ala 
1               5                   10                  15      


Glu Ala Pro Ala Asp Thr Pro Glu Pro Thr Ala Gly His Thr Leu Tyr 
            20                  25                  30          


Ser Val Leu Ser Gln Gly Tyr Glu Lys Leu Asp Thr Pro Leu Arg Pro 
        35                  40                  45              


Ala Arg Gln Gln Pro Thr Pro Thr Ser Asp Ser Ser Ser Asp Ser Asn 
    50                  55                  60                  


Leu Thr Thr Glu Glu Asp Glu Asp Arg Pro Glu Val His Lys Pro Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Glu Val Phe Asp Gln Val Thr Gln Glu Gly Ala Gly 
                85                  90                  95      


His Asp Pro Ala Pro Glu Gly Gln Ala Asp Tyr Asp Pro Val Thr Pro 
            100                 105                 110         


Tyr Val Thr Glu Val Glu Ser Val Val Gly Glu Asn Thr Met Tyr Ala 
        115                 120                 125             


Gln Val Phe Asn Leu Gln Gly Lys Thr Pro Val Ser Gln Lys Glu Glu 
    130                 135                 140                 


Ser Ser Ala Thr Ile Tyr Cys Ser Ile Arg Lys Pro Gln Val Val Pro 
145                 150                 155                 160 


Pro Pro Gln Gln Asn Asp Leu Glu Ile Pro Glu Ser Pro Thr Tyr Glu 
                165                 170                 175     


Asn Phe Thr 
            


<210> 65
<211> 55
<212> PRT
<213> Homo sapiens

<400> 65
Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
1               5                   10                  15      


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
            20                  25                  30          


Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
        35                  40                  45              


Gly Leu Asn Gln Arg Arg Ile 
    50                  55  


<210> 66
<211> 45
<212> PRT
<213> Homo sapiens

<400> 66
Gly Gln Asp Gly Val Arg Gln Ser Arg Ala Ser Asp Lys Gln Thr Leu 
1               5                   10                  15      


Leu Pro Asn Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp 
            20                  25                  30          


Gln Tyr Ser His Leu Gln Gly Asn Gln Leu Arg Arg Asn 
        35                  40                  45  


<210> 67
<211> 113
<212> PRT
<213> Homo sapiens

<400> 67
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210> 68
<211> 76
<212> PRT
<213> Homo sapiens

<400> 68
Ala Lys Thr Gly Arg Thr Ser Ile Gln Arg Asp Leu Lys Glu Gln Gln 
1               5                   10                  15      


Pro Gln Ala Leu Ala Pro Gly Arg Gly Pro Ser His Ser Ser Ala Phe 
            20                  25                  30          


Ser Met Ser Pro Leu Ser Thr Ala Gln Ala Pro Leu Pro Asn Pro Arg 
        35                  40                  45              


Thr Ala Ala Ser Ile Tyr Glu Glu Leu Leu Lys His Asp Thr Asn Ile 
    50                  55                  60                  


Tyr Cys Arg Met Asp His Lys Ala Glu Val Ala Ser 
65                  70                  75      


<210> 69
<211> 43
<212> PRT
<213> Homo sapiens

<400> 69
Lys His Arg Lys Gly Asn Asn Ala His Glu Asn Pro Lys Glu Val Ala 
1               5                   10                  15      


Ile His Leu His Ser Gln Gly Gly Ser Ser Val His Pro Arg Thr Leu 
            20                  25                  30          


Gln Thr Asn Glu Glu Asn Ser Arg Val Leu Pro 
        35                  40              


<210> 70
<211> 26
<212> PRT
<213> Homo sapiens

<400> 70
Arg Tyr Leu Gln Arg Arg Lys Lys Lys Gly Thr Tyr Leu Thr Asp Glu 
1               5                   10                  15      


Thr His Arg Glu Val Lys Phe Thr Ser Leu 
            20                  25      


<210> 71
<211> 46
<212> PRT
<213> Homo sapiens

<400> 71
Tyr Lys Lys Arg Arg Val His Leu Pro Gln Glu Gly Ala Phe Glu Asn 
1               5                   10                  15      


Thr Leu Tyr Phe Asn Ser Gln Ser Ser Pro Gly Thr Ser Asp Met Lys 
            20                  25                  30          


Asp Leu Val Gly Asn Ile Glu Gln Asn Glu His Ser Val Ile 
        35                  40                  45      


<210> 72
<211> 437
<212> PRT
<213> Homo sapiens

<400> 72
Arg Phe Cys Gly Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp Glu Glu 
1               5                   10                  15      


Lys Ile Pro Asn Pro Ser Lys Ser His Leu Phe Gln Asn Gly Ser Ala 
            20                  25                  30          


Glu Leu Trp Pro Pro Gly Ser Met Ser Ala Phe Thr Ser Gly Ser Pro 
        35                  40                  45              


Pro His Gln Gly Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu Gly Val 
    50                  55                  60                  


Phe Pro Val Gly Phe Gly Asp Ser Glu Val Ser Pro Leu Thr Ile Glu 
65                  70                  75                  80  


Asp Pro Lys His Val Cys Asp Pro Pro Ser Gly Pro Asp Thr Thr Pro 
                85                  90                  95      


Ala Ala Ser Asp Leu Pro Thr Glu Gln Pro Pro Ser Pro Gln Pro Gly 
            100                 105                 110         


Pro Pro Ala Ala Ser His Thr Pro Glu Lys Gln Ala Ser Ser Phe Asp 
        115                 120                 125             


Phe Asn Gly Pro Tyr Leu Gly Pro Pro His Ser Arg Ser Leu Pro Asp 
    130                 135                 140                 


Ile Leu Gly Gln Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln Lys Ser 
145                 150                 155                 160 


Pro Pro Pro Gly Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly Gly Gln 
                165                 170                 175     


Val Gln Leu Val Pro Leu Ala Gln Ala Met Gly Pro Gly Gln Ala Val 
            180                 185                 190         


Glu Val Glu Arg Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro Ser Leu 
        195                 200                 205             


Glu Ser Gly Gly Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg Val Gly 
    210                 215                 220                 


Gly Gln Asp Gln Lys Asp Ser Pro Val Ala Ile Pro Met Ser Ser Gly 
225                 230                 235                 240 


Asp Thr Glu Asp Pro Gly Val Ala Ser Gly Tyr Val Ser Ser Ala Asp 
                245                 250                 255     


Leu Val Phe Thr Pro Asn Ser Gly Ala Ser Ser Val Ser Leu Val Pro 
            260                 265                 270         


Ser Leu Gly Leu Pro Ser Asp Gln Thr Pro Ser Leu Cys Pro Gly Leu 
        275                 280                 285             


Ala Ser Gly Pro Pro Gly Ala Pro Gly Pro Val Lys Ser Gly Phe Glu 
    290                 295                 300                 


Gly Tyr Val Glu Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg Ser Pro 
305                 310                 315                 320 


Arg Asn Asn Pro Val Pro Pro Glu Ala Lys Ser Pro Val Leu Asn Pro 
                325                 330                 335     


Gly Glu Arg Pro Ala Asp Val Ser Pro Thr Ser Pro Gln Pro Glu Gly 
            340                 345                 350         


Leu Leu Val Leu Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro Gly Leu 
        355                 360                 365             


Gly Pro Gly Pro Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro Gly Pro 
    370                 375                 380                 


Gly Pro Glu Ile Lys Asn Leu Asp Gln Ala Phe Gln Val Lys Lys Pro 
385                 390                 395                 400 


Pro Gly Gln Ala Val Pro Gln Val Pro Val Ile Gln Leu Phe Lys Ala 
                405                 410                 415     


Leu Lys Gln Gln Asp Tyr Leu Ser Leu Pro Pro Trp Glu Val Asn Lys 
            420                 425                 430         


Pro Gly Glu Val Cys 
        435         


<210> 73
<211> 86
<212> PRT
<213> Homo sapiens

<400> 73
Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
1               5                   10                  15      


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            20                  25                  30          


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        35                  40                  45              


Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly 
    50                  55                  60                  


Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr 
65                  70                  75                  80  


Thr Leu Lys Pro Glu Thr 
                85      


<210> 74
<211> 119
<212> PRT
<213> Homo sapiens

<400> 74
Lys Leu Trp Arg Val Lys Lys Phe Leu Ile Pro Ser Val Pro Asp Pro 
1               5                   10                  15      


Lys Ser Ile Phe Pro Gly Leu Phe Glu Ile His Gln Gly Asn Phe Gln 
            20                  25                  30          


Glu Trp Ile Thr Asp Thr Gln Asn Val Ala His Leu His Lys Met Ala 
        35                  40                  45              


Gly Ala Glu Gln Glu Ser Gly Pro Glu Glu Pro Leu Val Val Gln Leu 
    50                  55                  60                  


Ala Lys Thr Glu Ala Glu Ser Pro Arg Met Leu Asp Pro Gln Thr Glu 
65                  70                  75                  80  


Glu Lys Glu Ala Ser Gly Gly Ser Leu Gln Leu Pro His Gln Pro Leu 
                85                  90                  95      


Gln Gly Gly Asp Val Val Thr Ile Gly Gly Phe Thr Phe Val Met Asn 
            100                 105                 110         


Asp Arg Ser Tyr Val Ala Leu 
        115                 


<210> 75
<211> 235
<212> PRT
<213> Homo sapiens

<400> 75
His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
1               5                   10                  15      


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
            20                  25                  30          


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
        35                  40                  45              


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
    50                  55                  60                  


Cys Trp Gly Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu Gly 
65                  70                  75                  80  


Pro Leu Leu Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr Leu 
                85                  90                  95      


Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp Leu 
            100                 105                 110         


Pro Gly Pro Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly Ser 
        115                 120                 125             


Glu Ala Ser Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro Glu 
    130                 135                 140                 


Gly Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser Ser 
145                 150                 155                 160 


Gln Leu Leu Arg Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr Pro 
                165                 170                 175     


Pro His Leu Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile Ser 
            180                 185                 190         


Thr Asp Tyr Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu Ser 
        195                 200                 205             


Asp Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala Ala 
    210                 215                 220                 


Glu Pro Leu Pro Pro Ser Tyr Val Ala Cys Ser 
225                 230                 235 


<210> 76
<211> 186
<212> PRT
<213> Homo sapiens

<400> 76
Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn Ser 
    50                  55                  60                  


Ser Glu Thr Cys Gly Leu Pro Thr Leu Val Gln Thr Tyr Val Leu Gln 
65                  70                  75                  80  


Gly Asp Pro Arg Ala Val Ser Thr Gln Pro Gln Ser Gln Ser Gly Thr 
                85                  90                  95      


Ser Asp Gln Val Leu Tyr Gly Gln Leu Leu Gly Ser Pro Thr Ser Pro 
            100                 105                 110         


Gly Pro Gly His Tyr Leu Arg Cys Asp Ser Thr Gln Pro Leu Leu Ala 
        115                 120                 125             


Gly Leu Thr Pro Ser Pro Lys Ser Tyr Glu Asn Leu Trp Phe Gln Ala 
    130                 135                 140                 


Ser Pro Leu Gly Thr Leu Val Thr Pro Ala Pro Ser Gln Glu Asp Asp 
145                 150                 155                 160 


Cys Val Phe Gly Pro Leu Leu Asn Phe Pro Leu Leu Gln Gly Ile Arg 
                165                 170                 175     


Val His Gly Met Glu Ala Leu Gly Ser Phe 
            180                 185     


<210> 77
<211> 54
<212> PRT
<213> Homo sapiens

<400> 77
Lys Arg Phe Leu Arg Ile Gln Arg Leu Phe Pro Pro Val Pro Gln Ile 
1               5                   10                  15      


Lys Asp Lys Leu Asn Asp Asn His Glu Val Glu Asp Glu Ile Ile Trp 
            20                  25                  30          


Glu Glu Phe Thr Pro Glu Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu 
        35                  40                  45              


Thr Val Lys Glu Ile Thr 
    50                  


<210> 78
<211> 100
<212> PRT
<213> Homo sapiens

<400> 78
Lys Val Phe Leu Arg Cys Ile Asn Tyr Val Phe Phe Pro Ser Leu Lys 
1               5                   10                  15      


Pro Ser Ser Ser Ile Asp Glu Tyr Phe Ser Glu Gln Pro Leu Lys Asn 
            20                  25                  30          


Leu Leu Leu Ser Thr Ser Glu Glu Gln Ile Glu Lys Cys Phe Ile Ile 
        35                  40                  45              


Glu Asn Ile Ser Thr Ile Ala Thr Val Glu Glu Thr Asn Gln Thr Asp 
    50                  55                  60                  


Glu Asp His Lys Lys Tyr Ser Ser Gln Thr Ser Gln Asp Ser Gly Asn 
65                  70                  75                  80  


Tyr Ser Asn Glu Asp Glu Ser Glu Ser Lys Thr Ser Glu Glu Leu Gln 
                85                  90                  95      


Gln Asp Phe Val 
            100 


<210> 79
<211> 251
<212> PRT
<213> Homo sapiens

<400> 79
Lys Trp Ile Gly Tyr Ile Cys Leu Arg Asn Ser Leu Pro Lys Val Leu 
1               5                   10                  15      


Asn Phe His Asn Phe Leu Ala Trp Pro Phe Pro Asn Leu Pro Pro Leu 
            20                  25                  30          


Glu Ala Met Asp Met Val Glu Val Ile Tyr Ile Asn Arg Lys Lys Lys 
        35                  40                  45              


Val Trp Asp Tyr Asn Tyr Asp Asp Glu Ser Asp Ser Asp Thr Glu Ala 
    50                  55                  60                  


Ala Pro Arg Thr Ser Gly Gly Gly Tyr Thr Met His Gly Leu Thr Val 
65                  70                  75                  80  


Arg Pro Leu Gly Gln Ala Ser Ala Thr Ser Thr Glu Ser Gln Leu Ile 
                85                  90                  95      


Asp Pro Glu Ser Glu Glu Glu Pro Asp Leu Pro Glu Val Asp Val Glu 
            100                 105                 110         


Leu Pro Thr Met Pro Lys Asp Ser Pro Gln Gln Leu Glu Leu Leu Ser 
        115                 120                 125             


Gly Pro Cys Glu Arg Arg Lys Ser Pro Leu Gln Asp Pro Phe Pro Glu 
    130                 135                 140                 


Glu Asp Tyr Ser Ser Thr Glu Gly Ser Gly Gly Arg Ile Thr Phe Asn 
145                 150                 155                 160 


Val Asp Leu Asn Ser Val Phe Leu Arg Val Leu Asp Asp Glu Asp Ser 
                165                 170                 175     


Asp Asp Leu Glu Ala Pro Leu Met Leu Ser Ser His Leu Glu Glu Met 
            180                 185                 190         


Val Asp Pro Glu Asp Pro Asp Asn Val Gln Ser Asn His Leu Leu Ala 
        195                 200                 205             


Ser Gly Glu Gly Thr Gln Pro Thr Phe Pro Ser Pro Ser Ser Glu Gly 
    210                 215                 220                 


Leu Trp Ser Glu Asp Ala Pro Ser Asp Gln Ser Asp Thr Ser Glu Ser 
225                 230                 235                 240 


Asp Val Asp Leu Gly Asp Gly Tyr Ile Met Arg 
                245                 250     


<210> 80
<211> 271
<212> PRT
<213> Homo sapiens

<400> 80
Lys Thr Leu Met Gly Asn Pro Trp Phe Gln Arg Ala Lys Met Pro Arg 
1               5                   10                  15      


Ala Leu Asp Phe Ser Gly His Thr His Pro Val Ala Thr Phe Gln Pro 
            20                  25                  30          


Ser Arg Pro Glu Ser Val Asn Asp Leu Phe Leu Cys Pro Gln Lys Glu 
        35                  40                  45              


Leu Thr Arg Gly Val Arg Pro Thr Pro Arg Val Arg Ala Pro Ala Thr 
    50                  55                  60                  


Gln Gln Thr Arg Trp Lys Lys Asp Leu Ala Glu Asp Glu Glu Glu Glu 
65                  70                  75                  80  


Asp Glu Glu Asp Thr Glu Asp Gly Val Ser Phe Gln Pro Tyr Ile Glu 
                85                  90                  95      


Pro Pro Ser Phe Leu Gly Gln Glu His Gln Ala Pro Gly His Ser Glu 
            100                 105                 110         


Ala Gly Gly Val Asp Ser Gly Arg Pro Arg Ala Pro Leu Val Pro Ser 
        115                 120                 125             


Glu Gly Ser Ser Ala Trp Asp Ser Ser Asp Arg Ser Trp Ala Ser Thr 
    130                 135                 140                 


Val Asp Ser Ser Trp Asp Arg Ala Gly Ser Ser Gly Tyr Leu Ala Glu 
145                 150                 155                 160 


Lys Gly Pro Gly Gln Gly Pro Gly Gly Asp Gly His Gln Glu Ser Leu 
                165                 170                 175     


Pro Pro Pro Glu Phe Ser Lys Asp Ser Gly Phe Leu Glu Glu Leu Pro 
            180                 185                 190         


Glu Asp Asn Leu Ser Ser Trp Ala Thr Trp Gly Thr Leu Pro Pro Glu 
        195                 200                 205             


Pro Asn Leu Val Pro Gly Gly Pro Pro Val Ser Leu Gln Thr Leu Thr 
    210                 215                 220                 


Phe Cys Trp Glu Ser Ser Pro Glu Glu Glu Glu Glu Ala Arg Glu Ser 
225                 230                 235                 240 


Glu Ile Glu Asp Ser Asp Ala Gly Ser Trp Gly Ala Glu Ser Thr Gln 
                245                 250                 255     


Arg Thr Glu Asp Arg Gly Arg Thr Leu Gly His Tyr Met Ala Arg 
            260                 265                 270     


<210> 81
<211> 182
<212> PRT
<213> Homo sapiens

<400> 81
Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu Asp Gly Lys Glu 
1               5                   10                  15      


Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu Glu Glu Glu Phe 
            20                  25                  30          


Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu Phe Gly Tyr Lys 
        35                  40                  45              


Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly Ile Val Thr Asp 
    50                  55                  60                  


Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu Leu Val Val Leu 
65                  70                  75                  80  


Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu Leu Glu Leu Lys 
                85                  90                  95      


Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile Asn Val Ile Leu 
            100                 105                 110         


Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys Glu Leu Lys Arg 
        115                 120                 125             


Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly Glu Lys Ser Lys 
    130                 135                 140                 


Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val Ala Met Pro Val 
145                 150                 155                 160 


Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln Gly Leu Ser Tyr 
                165                 170                 175     


Ser Ser Leu Lys Asn Val 
            180         


<210> 82
<211> 213
<212> PRT
<213> Homo sapiens

<400> 82
Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg Asp Ser Cys Tyr 
1               5                   10                  15      


Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr Tyr Asp Ala Tyr 
            20                  25                  30          


Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr Ser Asp Cys Asp 
        35                  40                  45              


Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu Lys Gln Cys Gly 
    50                  55                  60                  


Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val Gly Glu Asp Ile 
65                  70                  75                  80  


Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg Arg Leu Ile Ile 
                85                  90                  95      


Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu Gly Gly Ser Ser 
            100                 105                 110         


Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln Asp Gly Ile Lys 
        115                 120                 125             


Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr Glu Lys Met Pro 
    130                 135                 140                 


Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala Ile Arg Trp Ser 
145                 150                 155                 160 


Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr Arg Phe Trp Lys 
                165                 170                 175     


Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser Pro Ser Ser Lys 
            180                 185                 190         


His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu Gln Arg Glu Ala 
        195                 200                 205             


His Val Pro Leu Gly 
    210             


<210> 83
<211> 207
<212> PRT
<213> Homo sapiens

<400> 83
Leu Lys Met Phe Trp Ile Glu Ala Thr Leu Leu Trp Arg Asp Ile Ala 
1               5                   10                  15      


Lys Pro Tyr Lys Thr Arg Asn Asp Gly Lys Leu Tyr Asp Ala Tyr Val 
            20                  25                  30          


Val Tyr Pro Arg Asn Tyr Lys Ser Ser Thr Asp Gly Ala Ser Arg Val 
        35                  40                  45              


Glu His Phe Val His Gln Ile Leu Pro Asp Val Leu Glu Asn Lys Cys 
    50                  55                  60                  


Gly Tyr Thr Leu Cys Ile Tyr Gly Arg Asp Met Leu Pro Gly Glu Asp 
65                  70                  75                  80  


Val Val Thr Ala Val Glu Thr Asn Ile Arg Lys Ser Arg Arg His Ile 
                85                  90                  95      


Phe Ile Leu Thr Pro Gln Ile Thr His Asn Lys Glu Phe Ala Tyr Glu 
            100                 105                 110         


Gln Glu Val Ala Leu His Cys Ala Leu Ile Gln Asn Asp Ala Lys Val 
        115                 120                 125             


Ile Leu Ile Glu Met Glu Ala Leu Ser Glu Leu Asp Met Leu Gln Ala 
    130                 135                 140                 


Glu Ala Leu Gln Asp Ser Leu Gln His Leu Met Lys Val Gln Gly Thr 
145                 150                 155                 160 


Ile Lys Trp Arg Glu Asp His Ile Ala Asn Lys Arg Ser Leu Asn Ser 
                165                 170                 175     


Lys Phe Trp Lys His Val Arg Tyr Gln Met Pro Val Pro Ser Lys Ile 
            180                 185                 190         


Pro Arg Lys Ala Ser Ser Leu Thr Pro Leu Ala Ala Gln Lys Gln 
        195                 200                 205         


<210> 84
<211> 219
<212> PRT
<213> Homo sapiens

<400> 84
Asn Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg Ser Ala Phe His 
1               5                   10                  15      


Ser Thr Glu Thr Ile Val Asp Gly Lys Leu Tyr Asp Ala Tyr Val Leu 
            20                  25                  30          


Tyr Pro Lys Pro His Lys Glu Ser Gln Arg His Ala Val Asp Ala Leu 
        35                  40                  45              


Val Leu Asn Ile Leu Pro Glu Val Leu Glu Arg Gln Cys Gly Tyr Lys 
    50                  55                  60                  


Leu Phe Ile Phe Gly Arg Asp Glu Phe Pro Gly Gln Ala Val Ala Asn 
65                  70                  75                  80  


Val Ile Asp Glu Asn Val Lys Leu Cys Arg Arg Leu Ile Val Ile Val 
                85                  90                  95      


Val Pro Glu Ser Leu Gly Phe Gly Leu Leu Lys Asn Leu Ser Glu Glu 
            100                 105                 110         


Gln Ile Ala Val Tyr Ser Ala Leu Ile Gln Asp Gly Met Lys Val Ile 
        115                 120                 125             


Leu Ile Glu Leu Glu Lys Ile Glu Asp Tyr Thr Val Met Pro Glu Ser 
    130                 135                 140                 


Ile Gln Tyr Ile Lys Gln Lys His Gly Ala Ile Arg Trp His Gly Asp 
145                 150                 155                 160 


Phe Thr Glu Gln Ser Gln Cys Met Lys Thr Lys Phe Trp Lys Thr Val 
                165                 170                 175     


Arg Tyr His Met Pro Pro Arg Arg Cys Arg Pro Phe Pro Pro Val Gln 
            180                 185                 190         


Leu Leu Gln His Thr Pro Cys Tyr Arg Thr Ala Gly Pro Glu Leu Gly 
        195                 200                 205             


Ser Arg Arg Lys Lys Cys Thr Leu Thr Thr Gly 
    210                 215                 


<210> 85
<211> 31
<212> PRT
<213> Homo sapiens

<400> 85
Arg Leu Arg Arg Gly Gly Lys Asp Gly Ser Pro Lys Pro Gly Phe Leu 
1               5                   10                  15      


Ala Ser Val Ile Pro Val Asp Arg Arg Pro Gly Ala Pro Asn Leu 
            20                  25                  30      


<210> 86
<211> 92
<212> PRT
<213> Homo sapiens

<400> 86
Asn Arg Ala Ala Arg His Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala 
1               5                   10                  15      


Ser Ser Ala Ile Glu Phe Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile 
            20                  25                  30          


Asn Pro Val Asp Phe Gln Glu Glu Ala Ser Leu Gln Glu Ala Leu Val 
        35                  40                  45              


Val Glu Met Ser Trp Asp Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys 
    50                  55                  60                  


Thr Glu Leu Pro Glu Gly Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu 
65                  70                  75                  80  


Ser Leu Glu Asp Gly Asp Arg Cys Lys Ala Lys Met 
                85                  90          


<210> 87
<211> 219
<212> PRT
<213> Homo sapiens

<400> 87
His Tyr Phe Gln Gln Lys Val Phe Val Leu Leu Ala Ala Leu Arg Pro 
1               5                   10                  15      


Gln Trp Cys Ser Arg Glu Ile Pro Asp Pro Ala Asn Ser Thr Cys Ala 
            20                  25                  30          


Lys Lys Tyr Pro Ile Ala Glu Glu Lys Thr Gln Leu Pro Leu Asp Arg 
        35                  40                  45              


Leu Leu Ile Asp Trp Pro Thr Pro Glu Asp Pro Glu Pro Leu Val Ile 
    50                  55                  60                  


Ser Glu Val Leu His Gln Val Thr Pro Val Phe Arg His Pro Pro Cys 
65                  70                  75                  80  


Ser Asn Trp Pro Gln Arg Glu Lys Gly Ile Gln Gly His Gln Ala Ser 
                85                  90                  95      


Glu Lys Asp Met Met His Ser Ala Ser Ser Pro Pro Pro Pro Arg Ala 
            100                 105                 110         


Leu Gln Ala Glu Ser Arg Gln Leu Val Asp Leu Tyr Lys Val Leu Glu 
        115                 120                 125             


Ser Arg Gly Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr 
    130                 135                 140                 


Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser 
145                 150                 155                 160 


Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu 
                165                 170                 175     


Glu Glu Leu Glu Pro Gln His Ile Ser Leu Ser Val Phe Pro Ser Ser 
            180                 185                 190         


Ser Leu His Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu Thr Leu Asp 
        195                 200                 205             


Gln Leu Lys Met Arg Cys Asp Ser Leu Met Leu 
    210                 215                 


<210> 88
<211> 525
<212> PRT
<213> Homo sapiens

<400> 88
Cys Met Thr Trp Arg Leu Ala Gly Pro Gly Ser Glu Lys Tyr Ser Asp 
1               5                   10                  15      


Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala Asp Leu Ile Pro Pro 
            20                  25                  30          


Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr Ser Ala Asp His Pro 
        35                  40                  45              


Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln Phe Leu Leu Thr Ala 
    50                  55                  60                  


Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu Glu Gln Ala Ile Ser 
65                  70                  75                  80  


Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln Lys Gln Glu Met Val 
                85                  90                  95      


Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser Arg Gly Thr Arg Ala 
            100                 105                 110         


Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro Val Arg Leu Arg Cys 
        115                 120                 125             


Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr Ala Ala Met Asn Met 
    130                 135                 140                 


Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe Gly Thr Tyr Val Val 
145                 150                 155                 160 


Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp Val Pro Asp Leu Phe 
                165                 170                 175     


Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg Phe Glu Glu Val Tyr 
            180                 185                 190         


Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro Gly Arg Met His Arg 
        195                 200                 205             


Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg Ser Pro Gly Gly Arg 
    210                 215                 220                 


Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp Trp Gln Val Arg Cys 
225                 230                 235                 240 


Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser Ala Asp Asp Gln Asp 
                245                 250                 255     


Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu Pro Leu Leu Pro Pro 
            260                 265                 270         


Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val Arg Glu Pro Gly Ser 
        275                 280                 285             


Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly Glu Glu Gly Gly Ala 
    290                 295                 300                 


Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro Arg Gly Gln Pro Ala 
305                 310                 315                 320 


Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala Glu Glu Gly Ala Leu 
                325                 330                 335     


Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp Gly Ala Ala Val Arg 
            340                 345                 350         


Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro Leu Leu Gly Ser Pro 
        355                 360                 365             


Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro Val Asp Pro Glu Asp 
    370                 375                 380                 


Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser Pro Asp Leu Leu Pro 
385                 390                 395                 400 


Glu Asp Val Arg Glu His Leu Glu Gly Leu Met Leu Ser Leu Phe Glu 
                405                 410                 415     


Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys Ser Arg Pro Ala Met 
            420                 425                 430         


Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu Glu Gln Arg Gln Ser 
        435                 440                 445             


Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser Ser Pro Gln Pro Pro 
    450                 455                 460                 


Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu Glu Glu Gln Asp Pro 
465                 470                 475                 480 


Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp Leu Glu Ser Leu Arg 
                485                 490                 495     


Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu Gln Lys Asn Ser Gly 
            500                 505                 510         


Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro Ser Ala 
        515                 520                 525 


<210> 89
<211> 189
<212> PRT
<213> Homo sapiens

<400> 89
Arg His Glu Arg Ile Lys Lys Thr Ser Phe Ser Thr Thr Thr Leu Leu 
1               5                   10                  15      


Pro Pro Ile Lys Val Leu Val Val Tyr Pro Ser Glu Ile Cys Phe His 
            20                  25                  30          


His Thr Ile Cys Tyr Phe Thr Glu Phe Leu Gln Asn His Cys Arg Ser 
        35                  40                  45              


Glu Val Ile Leu Glu Lys Trp Gln Lys Lys Lys Ile Ala Glu Met Gly 
    50                  55                  60                  


Pro Val Gln Trp Leu Ala Thr Gln Lys Lys Ala Ala Asp Lys Val Val 
65                  70                  75                  80  


Phe Leu Leu Ser Asn Asp Val Asn Ser Val Cys Asp Gly Thr Cys Gly 
                85                  90                  95      


Lys Ser Glu Gly Ser Pro Ser Glu Asn Ser Gln Asp Leu Phe Pro Leu 
            100                 105                 110         


Ala Phe Asn Leu Phe Cys Ser Asp Leu Arg Ser Gln Ile His Leu His 
        115                 120                 125             


Lys Tyr Val Val Val Tyr Phe Arg Glu Ile Asp Thr Lys Asp Asp Tyr 
    130                 135                 140                 


Asn Ala Leu Ser Val Cys Pro Lys Tyr His Leu Met Lys Asp Ala Thr 
145                 150                 155                 160 


Ala Phe Cys Ala Glu Leu Leu His Val Lys Gln Gln Val Ser Ala Gly 
                165                 170                 175     


Lys Arg Ser Gln Ala Cys His Asp Gly Cys Cys Ser Leu 
            180                 185                 


<210> 90
<211> 232
<212> PRT
<213> Homo sapiens

<400> 90
Lys Lys Asp His Ala Lys Gly Trp Leu Arg Leu Leu Lys Gln Asp Val 
1               5                   10                  15      


Arg Ser Gly Ala Ala Ala Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser 
            20                  25                  30          


Ala Asp Asp Ser Gly Phe Glu Arg Leu Val Gly Ala Leu Ala Ser Ala 
        35                  40                  45              


Leu Cys Gln Leu Pro Leu Arg Val Ala Val Asp Leu Trp Ser Arg Arg 
    50                  55                  60                  


Glu Leu Ser Ala Gln Gly Pro Val Ala Trp Phe His Ala Gln Arg Arg 
65                  70                  75                  80  


Gln Thr Leu Gln Glu Gly Gly Val Val Val Leu Leu Phe Ser Pro Gly 
                85                  90                  95      


Ala Val Ala Leu Cys Ser Glu Trp Leu Gln Asp Gly Val Ser Gly Pro 
            100                 105                 110         


Gly Ala His Gly Pro His Asp Ala Phe Arg Ala Ser Leu Ser Cys Val 
        115                 120                 125             


Leu Pro Asp Phe Leu Gln Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala 
    130                 135                 140                 


Cys Phe Asp Arg Leu Leu His Pro Asp Ala Val Pro Ala Leu Phe Arg 
145                 150                 155                 160 


Thr Val Pro Val Phe Thr Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly 
                165                 170                 175     


Ala Leu Gln Gln Pro Arg Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg 
            180                 185                 190         


Ala Glu Gln Val Ser Arg Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe 
        195                 200                 205             


His Pro Pro Gly Thr Pro Ala Pro Gly Arg Gly Val Gly Pro Gly Ala 
    210                 215                 220                 


Gly Pro Gly Ala Gly Asp Gly Thr 
225                 230         


<210> 91
<211> 192
<212> PRT
<213> Homo sapiens

<400> 91
Thr Cys Arg Arg Pro Gln Ser Gly Pro Gly Pro Ala Arg Pro Val Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Asp Ser Glu Ala Gln Arg Arg Leu Val Gly Ala 
            20                  25                  30          


Leu Ala Glu Leu Leu Arg Ala Ala Leu Gly Gly Gly Arg Asp Val Ile 
        35                  40                  45              


Val Asp Leu Trp Glu Gly Arg His Val Ala Arg Val Gly Pro Leu Pro 
    50                  55                  60                  


Trp Leu Trp Ala Ala Arg Thr Arg Val Ala Arg Glu Gln Gly Thr Val 
65                  70                  75                  80  


Leu Leu Leu Trp Ser Gly Ala Asp Leu Arg Pro Val Ser Gly Pro Asp 
                85                  90                  95      


Pro Arg Ala Ala Pro Leu Leu Ala Leu Leu His Ala Ala Pro Arg Pro 
            100                 105                 110         


Leu Leu Leu Leu Ala Tyr Phe Ser Arg Leu Cys Ala Lys Gly Asp Ile 
        115                 120                 125             


Pro Pro Pro Leu Arg Ala Leu Pro Arg Tyr Arg Leu Leu Arg Asp Leu 
    130                 135                 140                 


Pro Arg Leu Leu Arg Ala Leu Asp Ala Arg Pro Phe Ala Glu Ala Thr 
145                 150                 155                 160 


Ser Trp Gly Arg Leu Gly Ala Arg Gln Arg Arg Gln Ser Arg Leu Glu 
                165                 170                 175     


Leu Cys Ser Arg Leu Glu Arg Glu Ala Ala Arg Leu Ala Asp Leu Gly 
            180                 185                 190         


<210> 92
<211> 191
<212> PRT
<213> Homo sapiens

<400> 92
Tyr Arg Val Asp Leu Val Leu Phe Tyr Arg His Leu Thr Arg Arg Asp 
1               5                   10                  15      


Glu Thr Leu Thr Asp Gly Lys Thr Tyr Asp Ala Phe Val Ser Tyr Leu 
            20                  25                  30          


Lys Glu Cys Arg Pro Glu Asn Gly Glu Glu His Thr Phe Ala Val Glu 
        35                  40                  45              


Ile Leu Pro Arg Val Leu Glu Lys His Phe Gly Tyr Lys Leu Cys Ile 
    50                  55                  60                  


Phe Glu Arg Asp Val Val Pro Gly Gly Ala Val Val Asp Glu Ile His 
65                  70                  75                  80  


Ser Leu Ile Glu Lys Ser Arg Arg Leu Ile Ile Val Leu Ser Lys Ser 
                85                  90                  95      


Tyr Met Ser Asn Glu Val Arg Tyr Glu Leu Glu Ser Gly Leu His Glu 
            100                 105                 110         


Ala Leu Val Glu Arg Lys Ile Lys Ile Ile Leu Ile Glu Phe Thr Pro 
        115                 120                 125             


Val Thr Asp Phe Thr Phe Leu Pro Gln Ser Leu Lys Leu Leu Lys Ser 
    130                 135                 140                 


His Arg Val Leu Lys Trp Lys Ala Asp Lys Ser Leu Ser Tyr Asn Ser 
145                 150                 155                 160 


Arg Phe Trp Lys Asn Leu Leu Tyr Leu Met Pro Ala Lys Thr Val Lys 
                165                 170                 175     


Pro Gly Arg Asp Glu Pro Glu Val Leu Pro Val Leu Ser Glu Ser 
            180                 185                 190     


<210> 93
<211> 222
<212> PRT
<213> Homo sapiens

<400> 93
Ser Ala Leu Leu Tyr Arg His Trp Ile Glu Ile Val Leu Leu Tyr Arg 
1               5                   10                  15      


Thr Tyr Gln Ser Lys Asp Gln Thr Leu Gly Asp Lys Lys Asp Phe Asp 
            20                  25                  30          


Ala Phe Val Ser Tyr Ala Lys Trp Ser Ser Phe Pro Ser Glu Ala Thr 
        35                  40                  45              


Ser Ser Leu Ser Glu Glu His Leu Ala Leu Ser Leu Phe Pro Asp Val 
    50                  55                  60                  


Leu Glu Asn Lys Tyr Gly Tyr Ser Leu Cys Leu Leu Glu Arg Asp Val 
65                  70                  75                  80  


Ala Pro Gly Gly Val Tyr Ala Glu Asp Ile Val Ser Ile Ile Lys Arg 
                85                  90                  95      


Ser Arg Arg Gly Ile Phe Ile Leu Ser Pro Asn Tyr Val Asn Gly Pro 
            100                 105                 110         


Ser Ile Phe Glu Leu Gln Ala Ala Val Asn Leu Ala Leu Asp Asp Gln 
        115                 120                 125             


Thr Leu Lys Leu Ile Leu Ile Lys Phe Cys Tyr Phe Gln Glu Pro Glu 
    130                 135                 140                 


Ser Leu Pro His Leu Val Lys Lys Ala Leu Arg Val Leu Pro Thr Val 
145                 150                 155                 160 


Thr Trp Arg Gly Leu Lys Ser Val Pro Pro Asn Ser Arg Phe Trp Ala 
                165                 170                 175     


Lys Met Arg Tyr His Met Pro Val Lys Asn Ser Gln Gly Phe Thr Trp 
            180                 185                 190         


Asn Gln Leu Arg Ile Thr Ser Arg Ile Phe Gln Trp Lys Gly Leu Ser 
        195                 200                 205             


Arg Thr Glu Thr Thr Gly Arg Ser Ser Gln Pro Lys Glu Trp 
    210                 215                 220         


<210> 94
<211> 286
<212> PRT
<213> Homo sapiens

<400> 94
Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu 
65                  70                  75                  80  


Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn 
                85                  90                  95      


Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala 
            100                 105                 110         


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp 
        115                 120                 125             


Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln 
    130                 135                 140                 


Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp 
145                 150                 155                 160 


Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro 
                165                 170                 175     


Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro 
            180                 185                 190         


Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly 
        195                 200                 205             


Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro 
    210                 215                 220                 


Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro 
225                 230                 235                 240 


Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu 
                245                 250                 255     


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
            260                 265                 270         


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285     


<210> 95
<211> 285
<212> PRT
<213> Homo sapiens

<400> 95
Ser Leu Lys Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala 
1               5                   10                  15      


Val Pro Ser Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser 
            20                  25                  30          


Gly Asp Phe Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu 
        35                  40                  45              


Glu Leu Gly Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr 
    50                  55                  60                  


Ser Cys His Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu 
65                  70                  75                  80  


Leu Gln Glu Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro 
                85                  90                  95      


Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu 
            100                 105                 110         


Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val 
        115                 120                 125             


Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp 
    130                 135                 140                 


Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly 
                165                 170                 175     


Cys Val Ser Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu 
            180                 185                 190         


Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly 
        195                 200                 205             


Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu 
    210                 215                 220                 


Ala Gly Ser Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly 
225                 230                 235                 240 


Phe Val Gly Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser 
                245                 250                 255     


Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val 
            260                 265                 270         


Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
        275                 280                 285 


<210> 96
<211> 325
<212> PRT
<213> Homo sapiens

<400> 96
Ser Tyr Arg Tyr Val Thr Lys Pro Pro Ala Pro Pro Asn Ser Leu Asn 
1               5                   10                  15      


Val Gln Arg Val Leu Thr Phe Gln Pro Leu Arg Phe Ile Gln Glu His 
            20                  25                  30          


Val Leu Ile Pro Val Phe Asp Leu Ser Gly Pro Ser Ser Leu Ala Gln 
        35                  40                  45              


Pro Val Gln Tyr Ser Gln Ile Arg Val Ser Gly Pro Arg Glu Pro Ala 
    50                  55                  60                  


Gly Ala Pro Gln Arg His Ser Leu Ser Glu Ile Thr Tyr Leu Gly Gln 
65                  70                  75                  80  


Pro Asp Ile Ser Ile Leu Gln Pro Ser Asn Val Pro Pro Pro Gln Ile 
                85                  90                  95      


Leu Ser Pro Leu Ser Tyr Ala Pro Asn Ala Ala Pro Glu Val Gly Pro 
            100                 105                 110         


Pro Ser Tyr Ala Pro Gln Val Thr Pro Glu Ala Gln Phe Pro Phe Tyr 
        115                 120                 125             


Ala Pro Gln Ala Ile Ser Lys Val Gln Pro Ser Ser Tyr Ala Pro Gln 
    130                 135                 140                 


Ala Thr Pro Asp Ser Trp Pro Pro Ser Tyr Gly Val Cys Met Glu Gly 
145                 150                 155                 160 


Ser Gly Lys Asp Ser Pro Thr Gly Thr Leu Ser Ser Pro Lys His Leu 
                165                 170                 175     


Arg Pro Lys Gly Gln Leu Gln Lys Glu Pro Pro Ala Gly Ser Cys Met 
            180                 185                 190         


Leu Gly Gly Leu Ser Leu Gln Glu Val Thr Ser Leu Ala Met Glu Glu 
        195                 200                 205             


Ser Gln Glu Ala Lys Ser Leu His Gln Pro Leu Gly Ile Cys Thr Asp 
    210                 215                 220                 


Arg Thr Ser Asp Pro Asn Val Leu His Ser Gly Glu Glu Gly Thr Pro 
225                 230                 235                 240 


Gln Tyr Leu Lys Gly Gln Leu Pro Leu Leu Ser Ser Val Gln Ile Glu 
                245                 250                 255     


Gly His Pro Met Ser Leu Pro Leu Gln Pro Pro Ser Arg Pro Cys Ser 
            260                 265                 270         


Pro Ser Asp Gln Gly Pro Ser Pro Trp Gly Leu Leu Glu Ser Leu Val 
        275                 280                 285             


Cys Pro Lys Asp Glu Ala Lys Ser Pro Ala Pro Glu Thr Ser Asp Leu 
    290                 295                 300                 


Glu Gln Pro Thr Glu Leu Asp Ser Leu Phe Arg Gly Leu Ala Leu Thr 
305                 310                 315                 320 


Val Gln Trp Glu Ser 
                325 


<210> 97
<211> 253
<212> PRT
<213> Homo sapiens

<400> 97
Asn Arg Ser Phe Arg Thr Gly Ile Lys Arg Arg Ile Leu Leu Leu Ile 
1               5                   10                  15      


Pro Lys Trp Leu Tyr Glu Asp Ile Pro Asn Met Lys Asn Ser Asn Val 
            20                  25                  30          


Val Lys Met Leu Gln Glu Asn Ser Glu Leu Met Asn Asn Asn Ser Ser 
        35                  40                  45              


Glu Gln Val Leu Tyr Val Asp Pro Met Ile Thr Glu Ile Lys Glu Ile 
    50                  55                  60                  


Phe Ile Pro Glu His Lys Pro Thr Asp Tyr Lys Lys Glu Asn Thr Gly 
65                  70                  75                  80  


Pro Leu Glu Thr Arg Asp Tyr Pro Gln Asn Ser Leu Phe Asp Asn Thr 
                85                  90                  95      


Thr Val Val Tyr Ile Pro Asp Leu Asn Thr Gly Tyr Lys Pro Gln Ile 
            100                 105                 110         


Ser Asn Phe Leu Pro Glu Gly Ser His Leu Ser Asn Asn Asn Glu Ile 
        115                 120                 125             


Thr Ser Leu Thr Leu Lys Pro Pro Val Asp Ser Leu Asp Ser Gly Asn 
    130                 135                 140                 


Asn Pro Arg Leu Gln Lys His Pro Asn Phe Ala Phe Ser Val Ser Ser 
145                 150                 155                 160 


Val Asn Ser Leu Ser Asn Thr Ile Phe Leu Gly Glu Leu Ser Leu Ile 
                165                 170                 175     


Leu Asn Gln Gly Glu Cys Ser Ser Pro Asp Ile Gln Asn Ser Val Glu 
            180                 185                 190         


Glu Glu Thr Thr Met Leu Leu Glu Asn Asp Ser Pro Ser Glu Thr Ile 
        195                 200                 205             


Pro Glu Gln Thr Leu Leu Pro Asp Glu Phe Val Ser Cys Leu Gly Ile 
    210                 215                 220                 


Val Asn Glu Glu Leu Pro Ser Ile Asn Thr Tyr Phe Pro Gln Asn Ile 
225                 230                 235                 240 


Leu Glu Ser His Phe Asn Arg Ile Ser Leu Leu Glu Lys 
                245                 250             


<210> 98
<211> 99
<212> PRT
<213> Homo sapiens

<400> 98
Thr Ser Gly Arg Cys Tyr His Leu Arg His Lys Val Leu Pro Arg Trp 
1               5                   10                  15      


Val Trp Glu Lys Val Pro Asp Pro Ala Asn Ser Ser Ser Gly Gln Pro 
            20                  25                  30          


His Met Glu Gln Val Pro Glu Ala Gln Pro Leu Gly Asp Leu Pro Ile 
        35                  40                  45              


Leu Glu Val Glu Glu Met Glu Pro Pro Pro Val Met Glu Ser Ser Gln 
    50                  55                  60                  


Pro Ala Gln Ala Thr Ala Pro Leu Asp Ser Gly Tyr Glu Lys His Phe 
65                  70                  75                  80  


Leu Pro Thr Pro Glu Glu Leu Gly Leu Leu Gly Pro Pro Arg Pro Gln 
                85                  90                  95      


Val Leu Ala 
            


<210> 99
<211> 53
<212> PRT
<213> Homo sapiens

<400> 99
Arg Arg Tyr Leu Val Met Gln Arg Leu Phe Pro Arg Ile Pro His Met 
1               5                   10                  15      


Lys Asp Pro Ile Gly Asp Ser Phe Gln Asn Asp Lys Leu Val Val Trp 
            20                  25                  30          


Glu Ala Gly Lys Ala Gly Leu Glu Glu Cys Leu Val Thr Glu Val Gln 
        35                  40                  45              


Val Val Gln Lys Thr 
    50              


<210> 100
<211> 277
<212> PRT
<213> Homo sapiens

<400> 100
Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp 
1               5                   10                  15      


Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro Arg 
            20                  25                  30          


His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe Thr 
        35                  40                  45              


Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe Pro 
    50                  55                  60                  


Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn Thr 
65                  70                  75                  80  


Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser Ser 
                85                  90                  95      


Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn Thr 
            100                 105                 110         


Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg His 
        115                 120                 125             


Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln Pro 
    130                 135                 140                 


Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp His 
145                 150                 155                 160 


Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys Gln 
                165                 170                 175     


Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu Arg 
            180                 185                 190         


Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu Lys 
        195                 200                 205             


Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln Met 
    210                 215                 220                 


Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly Thr 
225                 230                 235                 240 


Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala Thr 
                245                 250                 255     


Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln Gly 
            260                 265                 270         


Gly Tyr Met Pro Gln 
        275         


<210> 101
<211> 195
<212> PRT
<213> Homo sapiens

<400> 101
Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
    50                  55                  60                  


Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val 
65                  70                  75                  80  


Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser 
                85                  90                  95      


Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala 
            100                 105                 110         


Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu 
        115                 120                 125             


Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu 
    130                 135                 140                 


Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly 
145                 150                 155                 160 


Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser 
                165                 170                 175     


Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
            180                 185                 190         


Gln Asn Gln 
        195 


<210> 102
<211> 239
<212> PRT
<213> Homo sapiens

<400> 102
Tyr Arg Lys Arg Glu Trp Ile Lys Glu Thr Phe Tyr Pro Asp Ile Pro 
1               5                   10                  15      


Asn Pro Glu Asn Cys Lys Ala Leu Gln Phe Gln Lys Ser Val Cys Glu 
            20                  25                  30          


Gly Ser Ser Ala Leu Lys Thr Leu Glu Met Asn Pro Cys Thr Pro Asn 
        35                  40                  45              


Asn Val Glu Val Leu Glu Thr Arg Ser Ala Phe Pro Lys Ile Glu Asp 
    50                  55                  60                  


Thr Glu Ile Ile Ser Pro Val Ala Glu Arg Pro Glu Asp Arg Ser Asp 
65                  70                  75                  80  


Ala Glu Pro Glu Asn His Val Val Val Ser Tyr Cys Pro Pro Ile Ile 
                85                  90                  95      


Glu Glu Glu Ile Pro Asn Pro Ala Ala Asp Glu Ala Gly Gly Thr Ala 
            100                 105                 110         


Gln Val Ile Tyr Ile Asp Val Gln Ser Met Tyr Gln Pro Gln Ala Lys 
        115                 120                 125             


Pro Glu Glu Glu Gln Glu Asn Asp Pro Val Gly Gly Ala Gly Tyr Lys 
    130                 135                 140                 


Pro Gln Met His Leu Pro Ile Asn Ser Thr Val Glu Asp Ile Ala Ala 
145                 150                 155                 160 


Glu Glu Asp Leu Asp Lys Thr Ala Gly Tyr Arg Pro Gln Ala Asn Val 
                165                 170                 175     


Asn Thr Trp Asn Leu Val Ser Pro Asp Ser Pro Arg Ser Ile Asp Ser 
            180                 185                 190         


Asn Ser Glu Ile Val Ser Phe Gly Ser Pro Cys Ser Ile Asn Ser Arg 
        195                 200                 205             


Gln Phe Leu Ile Pro Pro Lys Asp Glu Asp Ser Pro Lys Ser Asn Gly 
    210                 215                 220                 


Gly Gly Trp Ser Phe Thr Asn Phe Phe Gln Asn Lys Pro Asn Asp 
225                 230                 235                 


<210> 103
<211> 434
<212> PRT
<213> Homo sapiens

<400> 103
Lys Tyr Lys Gln Lys Pro Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu 
1               5                   10                  15      


Ser Tyr Glu Gly Asn Ser Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro 
            20                  25                  30          


Tyr Asn Glu Lys Trp Glu Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys 
        35                  40                  45              


Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala Phe 
    50                  55                  60                  


Gly Leu Gly Lys Glu Asp Ala Val Leu Lys Val Ala Val Lys Met Leu 
65                  70                  75                  80  


Lys Ser Thr Ala His Ala Asp Glu Lys Glu Ala Leu Met Ser Glu Leu 
                85                  90                  95      


Lys Ile Met Ser His Leu Gly Gln His Glu Asn Ile Val Asn Leu Leu 
            100                 105                 110         


Gly Ala Cys Thr His Gly Gly Pro Val Leu Val Ile Thr Glu Tyr Cys 
        115                 120                 125             


Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Ala Glu Ala Met 
    130                 135                 140                 


Leu Gly Pro Ser Leu Ser Pro Gly Gln Asp Pro Glu Gly Gly Val Asp 
145                 150                 155                 160 


Tyr Lys Asn Ile His Leu Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly 
                165                 170                 175     


Phe Ser Ser Gln Gly Val Asp Thr Tyr Val Glu Met Arg Pro Val Ser 
            180                 185                 190         


Thr Ser Ser Asn Asp Ser Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp 
        195                 200                 205             


Gly Arg Pro Leu Glu Leu Arg Asp Leu Leu His Phe Ser Ser Gln Val 
    210                 215                 220                 


Ala Gln Gly Met Ala Phe Leu Ala Ser Lys Asn Cys Ile His Arg Asp 
225                 230                 235                 240 


Val Ala Ala Arg Asn Val Leu Leu Thr Asn Gly His Val Ala Lys Ile 
                245                 250                 255     


Gly Asp Phe Gly Leu Ala Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile 
            260                 265                 270         


Val Lys Gly Asn Ala Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser 
        275                 280                 285             


Ile Phe Asp Cys Val Tyr Thr Val Gln Ser Asp Val Trp Ser Tyr Gly 
    290                 295                 300                 


Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly 
305                 310                 315                 320 


Ile Leu Val Asn Ser Lys Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln 
                325                 330                 335     


Met Ala Gln Pro Ala Phe Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln 
            340                 345                 350         


Ala Cys Trp Ala Leu Glu Pro Thr His Arg Pro Thr Phe Gln Gln Ile 
        355                 360                 365             


Cys Ser Phe Leu Gln Glu Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp 
    370                 375                 380                 


Tyr Thr Asn Leu Pro Ser Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser 
385                 390                 395                 400 


Ser Ser Glu Leu Glu Glu Glu Ser Ser Ser Glu His Leu Thr Cys Cys 
                405                 410                 415     


Glu Gln Gly Asp Ile Ala Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln 
            420                 425                 430         


Phe Cys 
        


<210> 104
<211> 218
<212> PRT
<213> Homo sapiens

<400> 104
Lys Ser Gln Trp Ile Lys Glu Thr Cys Tyr Pro Asp Ile Pro Asp Pro 
1               5                   10                  15      


Tyr Lys Ser Ser Ile Leu Ser Leu Ile Lys Phe Lys Glu Asn Pro His 
            20                  25                  30          


Leu Ile Ile Met Asn Val Ser Asp Cys Ile Pro Asp Ala Ile Glu Val 
        35                  40                  45              


Val Ser Lys Pro Glu Gly Thr Lys Ile Gln Phe Leu Gly Thr Arg Lys 
    50                  55                  60                  


Ser Leu Thr Glu Thr Glu Leu Thr Lys Pro Asn Tyr Leu Tyr Leu Leu 
65                  70                  75                  80  


Pro Thr Glu Lys Asn His Ser Gly Pro Gly Pro Cys Ile Cys Phe Glu 
                85                  90                  95      


Asn Leu Thr Tyr Asn Gln Ala Ala Ser Asp Ser Gly Ser Cys Gly His 
            100                 105                 110         


Val Pro Val Ser Pro Lys Ala Pro Ser Met Leu Gly Leu Met Thr Ser 
        115                 120                 125             


Pro Glu Asn Val Leu Lys Ala Leu Glu Lys Asn Tyr Met Asn Ser Leu 
    130                 135                 140                 


Gly Glu Ile Pro Ala Gly Glu Thr Ser Leu Asn Tyr Val Ser Gln Leu 
145                 150                 155                 160 


Ala Ser Pro Met Phe Gly Asp Lys Asp Ser Leu Pro Thr Asn Pro Val 
                165                 170                 175     


Glu Ala Pro His Cys Ser Glu Tyr Lys Met Gln Met Ala Val Ser Leu 
            180                 185                 190         


Arg Leu Ala Leu Pro Pro Pro Thr Glu Asn Ser Ser Leu Ser Ser Ile 
        195                 200                 205             


Thr Leu Leu Asp Pro Gly Glu His Tyr Cys 
    210                 215             


<210> 105
<211> 542
<212> PRT
<213> Homo sapiens

<400> 105
Arg Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln 
1               5                   10                  15      


Glu Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn 
            20                  25                  30          


Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys 
        35                  40                  45              


Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile 
    50                  55                  60                  


Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg 
65                  70                  75                  80  


Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr 
                85                  90                  95      


Val Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile 
            100                 105                 110         


Cys Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly 
        115                 120                 125             


Cys Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln 
    130                 135                 140                 


Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu 
145                 150                 155                 160 


Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu 
                165                 170                 175     


Val Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys 
            180                 185                 190         


Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val 
        195                 200                 205             


Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr 
    210                 215                 220                 


His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met 
225                 230                 235                 240 


Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser 
                245                 250                 255     


Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr 
            260                 265                 270         


Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp 
        275                 280                 285             


Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala 
    290                 295                 300                 


Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His 
305                 310                 315                 320 


Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu 
                325                 330                 335     


Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln 
            340                 345                 350         


Gln Gly Phe Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser 
        355                 360                 365             


Ser Leu Ser Ala Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg 
    370                 375                 380                 


Asn Gly Leu Gln Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg 
385                 390                 395                 400 


Tyr Ser Ser Asp Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp Asp 
                405                 410                 415     


Thr Phe Leu Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg 
            420                 425                 430         


Pro Ala Gly Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn 
        435                 440                 445             


Pro Ala Pro Ser Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala 
    450                 455                 460                 


Val Gly Asn Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn 
465                 470                 475                 480 


Ser Thr Phe Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser His Gln 
                485                 490                 495     


Ile Ser Leu Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu 
            500                 505                 510         


Ala Lys Pro Asn Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu 
        515                 520                 525             


Tyr Leu Arg Val Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala 
    530                 535                 540         


<210> 106
<211> 350
<212> PRT
<213> Homo sapiens

<400> 106
Lys Gln Gln Arg Ile Lys Met Leu Ile Leu Pro Pro Val Pro Val Pro 
1               5                   10                  15      


Lys Ile Lys Gly Ile Asp Pro Asp Leu Leu Lys Glu Gly Lys Leu Glu 
            20                  25                  30          


Glu Val Asn Thr Ile Leu Ala Ile His Asp Ser Tyr Lys Pro Glu Phe 
        35                  40                  45              


His Ser Asp Asp Ser Trp Val Glu Phe Ile Glu Leu Asp Ile Asp Glu 
    50                  55                  60                  


Pro Asp Glu Lys Thr Glu Glu Ser Asp Thr Asp Arg Leu Leu Ser Ser 
65                  70                  75                  80  


Asp His Glu Lys Ser His Ser Asn Leu Gly Val Lys Asp Gly Asp Ser 
                85                  90                  95      


Gly Arg Thr Ser Cys Cys Glu Pro Asp Ile Leu Glu Thr Asp Phe Asn 
            100                 105                 110         


Ala Asn Asp Ile His Glu Gly Thr Ser Glu Val Ala Gln Pro Gln Arg 
        115                 120                 125             


Leu Lys Gly Glu Ala Asp Leu Leu Cys Leu Asp Gln Lys Asn Gln Asn 
    130                 135                 140                 


Asn Ser Pro Tyr His Asp Ala Cys Pro Ala Thr Gln Gln Pro Ser Val 
145                 150                 155                 160 


Ile Gln Ala Glu Lys Asn Lys Pro Gln Pro Leu Pro Thr Glu Gly Ala 
                165                 170                 175     


Glu Ser Thr His Gln Ala Ala His Ile Gln Leu Ser Asn Pro Ser Ser 
            180                 185                 190         


Leu Ser Asn Ile Asp Phe Tyr Ala Gln Val Ser Asp Ile Thr Pro Ala 
        195                 200                 205             


Gly Ser Val Val Leu Ser Pro Gly Gln Lys Asn Lys Ala Gly Met Ser 
    210                 215                 220                 


Gln Cys Asp Met His Pro Glu Met Val Ser Leu Cys Gln Glu Asn Phe 
225                 230                 235                 240 


Leu Met Asp Asn Ala Tyr Phe Cys Glu Ala Asp Ala Lys Lys Cys Ile 
                245                 250                 255     


Pro Val Ala Pro His Ile Lys Val Glu Ser His Ile Gln Pro Ser Leu 
            260                 265                 270         


Asn Gln Glu Asp Ile Tyr Ile Thr Thr Glu Ser Leu Thr Thr Ala Ala 
        275                 280                 285             


Gly Arg Pro Gly Thr Gly Glu His Val Pro Gly Ser Glu Met Pro Val 
    290                 295                 300                 


Pro Asp Tyr Thr Ser Ile His Ile Val Gln Ser Pro Gln Gly Leu Ile 
305                 310                 315                 320 


Leu Asn Ala Thr Ala Leu Pro Leu Pro Asp Lys Glu Phe Leu Ser Ser 
                325                 330                 335     


Cys Gly Tyr Val Ser Thr Asp Gln Leu Asn Lys Ile Met Pro 
            340                 345                 350 


<210> 107
<211> 403
<212> PRT
<213> Homo sapiens

<400> 107
Arg Lys Arg Gln Pro Asp Gly Pro Leu Gly Pro Leu Tyr Ala Ser Ser 
1               5                   10                  15      


Asn Pro Glu Tyr Leu Ser Ala Ser Asp Val Phe Pro Cys Ser Val Tyr 
            20                  25                  30          


Val Pro Asp Glu Trp Glu Val Ser Arg Glu Lys Ile Thr Leu Leu Arg 
        35                  40                  45              


Glu Leu Gly Gln Gly Ser Phe Gly Met Val Tyr Glu Gly Asn Ala Arg 
    50                  55                  60                  


Asp Ile Ile Lys Gly Glu Ala Glu Thr Arg Val Ala Val Lys Thr Val 
65                  70                  75                  80  


Asn Glu Ser Ala Ser Leu Arg Glu Arg Ile Glu Phe Leu Asn Glu Ala 
                85                  90                  95      


Ser Val Met Lys Gly Phe Thr Cys His His Val Val Arg Leu Leu Gly 
            100                 105                 110         


Val Val Ser Lys Gly Gln Pro Thr Leu Val Val Met Glu Leu Met Ala 
        115                 120                 125             


His Gly Asp Leu Lys Ser Tyr Leu Arg Ser Leu Arg Pro Glu Ala Glu 
    130                 135                 140                 


Asn Asn Pro Gly Arg Pro Pro Pro Thr Leu Gln Glu Met Ile Gln Met 
145                 150                 155                 160 


Ala Ala Glu Ile Ala Asp Gly Met Ala Tyr Leu Asn Ala Lys Lys Phe 
                165                 170                 175     


Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Val Ala His Asp Phe 
            180                 185                 190         


Thr Val Lys Ile Gly Asp Phe Gly Met Thr Arg Asp Ile Tyr Glu Thr 
        195                 200                 205             


Asp Tyr Tyr Arg Lys Gly Gly Lys Gly Leu Leu Pro Val Arg Trp Met 
    210                 215                 220                 


Ala Pro Glu Ser Leu Lys Asp Gly Val Phe Thr Thr Ser Ser Asp Met 
225                 230                 235                 240 


Trp Ser Phe Gly Val Val Leu Trp Glu Ile Thr Ser Leu Ala Glu Gln 
                245                 250                 255     


Pro Tyr Gln Gly Leu Ser Asn Glu Gln Val Leu Lys Phe Val Met Asp 
            260                 265                 270         


Gly Gly Tyr Leu Asp Gln Pro Asp Asn Cys Pro Glu Arg Val Thr Asp 
        275                 280                 285             


Leu Met Arg Met Cys Trp Gln Phe Asn Pro Lys Met Arg Pro Thr Phe 
    290                 295                 300                 


Leu Glu Ile Val Asn Leu Leu Lys Asp Asp Leu His Pro Ser Phe Pro 
305                 310                 315                 320 


Glu Val Ser Phe Phe His Ser Glu Glu Asn Lys Ala Pro Glu Ser Glu 
                325                 330                 335     


Glu Leu Glu Met Glu Phe Glu Asp Met Glu Asn Val Pro Leu Asp Arg 
            340                 345                 350         


Ser Ser His Cys Gln Arg Glu Glu Ala Gly Gly Arg Asp Gly Gly Ser 
        355                 360                 365             


Ser Leu Gly Phe Lys Arg Ser Tyr Glu Glu His Ile Pro Tyr Thr His 
    370                 375                 380                 


Met Asn Gly Gly Lys Lys Asn Gly Arg Ile Leu Thr Leu Pro Arg Ser 
385                 390                 395                 400 


Asn Pro Ser 
            


<210> 108
<211> 303
<212> PRT
<213> Homo sapiens

<400> 108
Ser His Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro 
1               5                   10                  15      


Lys Asn Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Pro Glu Thr 
            20                  25                  30          


Phe Glu His Leu Phe Ile Lys His Thr Ala Ser Val Thr Cys Gly Pro 
        35                  40                  45              


Leu Leu Leu Glu Pro Glu Thr Ile Ser Glu Asp Ile Ser Val Asp Thr 
    50                  55                  60                  


Ser Trp Lys Asn Lys Asp Glu Met Met Pro Thr Thr Val Val Ser Leu 
65                  70                  75                  80  


Leu Ser Thr Thr Asp Leu Glu Lys Gly Ser Val Cys Ile Ser Asp Gln 
                85                  90                  95      


Phe Asn Ser Val Asn Phe Ser Glu Ala Glu Gly Thr Glu Val Thr Tyr 
            100                 105                 110         


Glu Asp Glu Ser Gln Arg Gln Pro Phe Val Lys Tyr Ala Thr Leu Ile 
        115                 120                 125             


Ser Asn Ser Lys Pro Ser Glu Thr Gly Glu Glu Gln Gly Leu Ile Asn 
    130                 135                 140                 


Ser Ser Val Thr Lys Cys Phe Ser Ser Lys Asn Ser Pro Leu Lys Asp 
145                 150                 155                 160 


Ser Phe Ser Asn Ser Ser Trp Glu Ile Glu Ala Gln Ala Phe Phe Ile 
                165                 170                 175     


Leu Ser Asp Gln His Pro Asn Ile Ile Ser Pro His Leu Thr Phe Ser 
            180                 185                 190         


Glu Gly Leu Asp Glu Leu Leu Lys Leu Glu Gly Asn Phe Pro Glu Glu 
        195                 200                 205             


Asn Asn Asp Lys Lys Ser Ile Tyr Tyr Leu Gly Val Thr Ser Ile Lys 
    210                 215                 220                 


Lys Arg Glu Ser Gly Val Leu Leu Thr Asp Lys Ser Arg Val Ser Cys 
225                 230                 235                 240 


Pro Phe Pro Ala Pro Cys Leu Phe Thr Asp Ile Arg Val Leu Gln Asp 
                245                 250                 255     


Ser Cys Ser His Phe Val Glu Asn Asn Ile Asn Leu Gly Thr Ser Ser 
            260                 265                 270         


Lys Lys Thr Phe Ala Ser Tyr Met Pro Gln Phe Gln Thr Cys Ser Thr 
        275                 280                 285             


Gln Thr His Lys Ile Met Glu Asn Lys Met Cys Asp Leu Thr Val 
    290                 295                 300             


<210> 109
<211> 364
<212> PRT
<213> Homo sapiens

<400> 109
Lys Gly Tyr Ser Met Val Thr Cys Ile Phe Pro Pro Val Pro Gly Pro 
1               5                   10                  15      


Lys Ile Lys Gly Phe Asp Ala His Leu Leu Glu Lys Gly Lys Ser Glu 
            20                  25                  30          


Glu Leu Leu Ser Ala Leu Gly Cys Gln Asp Phe Pro Pro Thr Ser Asp 
        35                  40                  45              


Tyr Glu Asp Leu Leu Val Glu Tyr Leu Glu Val Asp Asp Ser Glu Asp 
    50                  55                  60                  


Gln His Leu Met Ser Val His Ser Lys Glu His Pro Ser Gln Gly Met 
65                  70                  75                  80  


Lys Pro Thr Tyr Leu Asp Pro Asp Thr Asp Ser Gly Arg Gly Ser Cys 
                85                  90                  95      


Asp Ser Pro Ser Leu Leu Ser Glu Lys Cys Glu Glu Pro Gln Ala Asn 
            100                 105                 110         


Pro Ser Thr Phe Tyr Asp Pro Glu Val Ile Glu Lys Pro Glu Asn Pro 
        115                 120                 125             


Glu Thr Thr His Thr Trp Asp Pro Gln Cys Ile Ser Met Glu Gly Lys 
    130                 135                 140                 


Ile Pro Tyr Phe His Ala Gly Gly Ser Lys Cys Ser Thr Trp Pro Leu 
145                 150                 155                 160 


Pro Gln Pro Ser Gln His Asn Pro Arg Ser Ser Tyr His Asn Ile Thr 
                165                 170                 175     


Asp Val Cys Glu Leu Ala Val Gly Pro Ala Gly Ala Pro Ala Thr Leu 
            180                 185                 190         


Leu Asn Glu Ala Gly Lys Asp Ala Leu Lys Ser Ser Gln Thr Ile Lys 
        195                 200                 205             


Ser Arg Glu Glu Gly Lys Ala Thr Gln Gln Arg Glu Val Glu Ser Phe 
    210                 215                 220                 


His Ser Glu Thr Asp Gln Asp Thr Pro Trp Leu Leu Pro Gln Glu Lys 
225                 230                 235                 240 


Thr Pro Phe Gly Ser Ala Lys Pro Leu Asp Tyr Val Glu Ile His Lys 
                245                 250                 255     


Val Asn Lys Asp Gly Ala Leu Ser Leu Leu Pro Lys Gln Arg Glu Asn 
            260                 265                 270         


Ser Gly Lys Pro Lys Lys Pro Gly Thr Pro Glu Asn Asn Lys Glu Tyr 
        275                 280                 285             


Ala Lys Val Ser Gly Val Met Asp Asn Asn Ile Leu Val Leu Val Pro 
    290                 295                 300                 


Asp Pro His Ala Lys Asn Val Ala Cys Phe Glu Glu Ser Ala Lys Glu 
305                 310                 315                 320 


Ala Pro Pro Ser Leu Glu Gln Asn Gln Ala Glu Lys Ala Leu Ala Asn 
                325                 330                 335     


Phe Thr Ala Thr Ser Ser Lys Cys Arg Leu Gln Leu Gly Gly Leu Asp 
            340                 345                 350         


Tyr Leu Asp Pro Ala Cys Phe Thr His Ser Phe His 
        355                 360                 


<210> 110
<211> 122
<212> PRT
<213> Homo sapiens

<400> 110
Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
1               5                   10                  15      


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
            20                  25                  30          


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
        35                  40                  45              


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
    50                  55                  60                  


Thr Pro Leu Pro Leu Cys Ser Ser Gln Ala Gln Met Asp Tyr Arg Arg 
65                  70                  75                  80  


Leu Gln Pro Ser Cys Leu Gly Thr Met Pro Leu Ser Val Cys Pro Pro 
                85                  90                  95      


Met Ala Glu Ser Gly Ser Cys Cys Thr Thr His Ile Ala Asn His Ser 
            100                 105                 110         


Tyr Leu Pro Leu Ser Tyr Trp Gln Gln Pro 
        115                 120         


<210> 111
<211> 542
<212> PRT
<213> Homo sapiens

<400> 111
Arg Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln 
1               5                   10                  15      


Glu Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn 
            20                  25                  30          


Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys 
        35                  40                  45              


Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile 
    50                  55                  60                  


Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg 
65                  70                  75                  80  


Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr 
                85                  90                  95      


Val Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile 
            100                 105                 110         


Cys Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly 
        115                 120                 125             


Cys Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln 
    130                 135                 140                 


Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu 
145                 150                 155                 160 


Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu 
                165                 170                 175     


Val Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys 
            180                 185                 190         


Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val 
        195                 200                 205             


Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr 
    210                 215                 220                 


His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met 
225                 230                 235                 240 


Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser 
                245                 250                 255     


Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr 
            260                 265                 270         


Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp 
        275                 280                 285             


Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala 
    290                 295                 300                 


Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His 
305                 310                 315                 320 


Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu 
                325                 330                 335     


Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln 
            340                 345                 350         


Gln Gly Phe Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser 
        355                 360                 365             


Ser Leu Ser Ala Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg 
    370                 375                 380                 


Asn Gly Leu Gln Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg 
385                 390                 395                 400 


Tyr Ser Ser Asp Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp Asp 
                405                 410                 415     


Thr Phe Leu Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg 
            420                 425                 430         


Pro Ala Gly Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn 
        435                 440                 445             


Pro Ala Pro Ser Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala 
    450                 455                 460                 


Val Gly Asn Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn 
465                 470                 475                 480 


Ser Thr Phe Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser His Gln 
                485                 490                 495     


Ile Ser Leu Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu 
            500                 505                 510         


Ala Lys Pro Asn Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu 
        515                 520                 525             


Tyr Leu Arg Val Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala 
    530                 535                 540         


<210> 112
<211> 580
<212> PRT
<213> Homo sapiens

<400> 112
Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg Arg Leu Leu 
1               5                   10                  15      


Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Ala Met Pro 
            20                  25                  30          


Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu Arg Lys Val 
        35                  40                  45              


Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile Trp 
    50                  55                  60                  


Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile Lys Val Leu 
65                  70                  75                  80  


Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala 
                85                  90                  95      


Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg Leu Leu Gly 
            100                 105                 110         


Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu Met Pro Tyr 
        115                 120                 125             


Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg Leu Gly Ser 
    130                 135                 140                 


Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly Met Ser Tyr 
145                 150                 155                 160 


Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val 
                165                 170                 175     


Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu Ala 
            180                 185                 190         


Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp Gly Gly Lys 
        195                 200                 205             


Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg Arg Arg Phe 
    210                 215                 220                 


Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu 
225                 230                 235                 240 


Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala Arg Glu Ile 
                245                 250                 255     


Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys 
            260                 265                 270         


Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ser 
        275                 280                 285             


Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe Ser Arg Met 
    290                 295                 300                 


Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu Asp Leu Gly 
305                 310                 315                 320 


Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu Leu Glu Asp 
                325                 330                 335     


Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr Leu Val Pro Gln 
            340                 345                 350         


Gln Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly Ala Gly Gly Met Val 
        355                 360                 365             


His His Arg His Arg Ser Ser Ser Thr Arg Ser Gly Gly Gly Asp Leu 
    370                 375                 380                 


Thr Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala Pro Arg Ser Pro Leu 
385                 390                 395                 400 


Ala Pro Ser Glu Gly Ala Gly Ser Asp Val Phe Asp Gly Asp Leu Gly 
                405                 410                 415     


Met Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro Thr His Asp Pro Ser 
            420                 425                 430         


Pro Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val Pro Leu Pro Ser Glu 
        435                 440                 445             


Thr Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser Pro Gln Pro Glu Tyr 
    450                 455                 460                 


Val Asn Gln Pro Asp Val Arg Pro Gln Pro Pro Ser Pro Arg Glu Gly 
465                 470                 475                 480 


Pro Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu Arg Pro Lys 
                485                 490                 495     


Thr Leu Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val Phe Ala Phe 
            500                 505                 510         


Gly Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln Gly Gly Ala 
        515                 520                 525             


Ala Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala Phe Asp Asn 
    530                 535                 540                 


Leu Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala Pro Pro Ser 
545                 550                 555                 560 


Thr Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr Leu Gly Leu 
                565                 570                 575     


Asp Val Pro Val 
            580 


<210> 113
<211> 435
<212> PRT
<213> Homo sapiens

<400> 113
Lys Lys Arg Lys Gln Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr 
1               5                   10                  15      


Asp Ala Arg Val His Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg 
            20                  25                  30          


Ser Val Ser Pro Thr Thr Glu Met Val Ser Asn Glu Ser Val Asp Tyr 
        35                  40                  45              


Arg Ala Thr Phe Pro Glu Asp Gln Phe Pro Asn Ser Ser Gln Asn Gly 
    50                  55                  60                  


Ser Cys Arg Gln Val Gln Tyr Pro Leu Thr Asp Met Ser Pro Ile Leu 
65                  70                  75                  80  


Thr Ser Gly Asp Ser Asp Ile Ser Ser Pro Leu Leu Gln Asn Thr Val 
                85                  90                  95      


His Ile Asp Leu Ser Ala Leu Asn Pro Glu Leu Val Gln Ala Val Gln 
            100                 105                 110         


His Val Val Ile Gly Pro Ser Ser Leu Ile Val His Phe Asn Glu Val 
        115                 120                 125             


Ile Gly Arg Gly His Phe Gly Cys Val Tyr His Gly Thr Leu Leu Asp 
    130                 135                 140                 


Asn Asp Gly Lys Lys Ile His Cys Ala Val Lys Ser Leu Asn Arg Ile 
145                 150                 155                 160 


Thr Asp Ile Gly Glu Val Ser Gln Phe Leu Thr Glu Gly Ile Ile Met 
                165                 170                 175     


Lys Asp Phe Ser His Pro Asn Val Leu Ser Leu Leu Gly Ile Cys Leu 
            180                 185                 190         


Arg Ser Glu Gly Ser Pro Leu Val Val Leu Pro Tyr Met Lys His Gly 
        195                 200                 205             


Asp Leu Arg Asn Phe Ile Arg Asn Glu Thr His Asn Pro Thr Val Lys 
    210                 215                 220                 


Asp Leu Ile Gly Phe Gly Leu Gln Val Ala Lys Gly Met Lys Tyr Leu 
225                 230                 235                 240 


Ala Ser Lys Lys Phe Val His Arg Asp Leu Ala Ala Arg Asn Cys Met 
                245                 250                 255     


Leu Asp Glu Lys Phe Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg 
            260                 265                 270         


Asp Met Tyr Asp Lys Glu Tyr Tyr Ser Val His Asn Lys Thr Gly Ala 
        275                 280                 285             


Lys Leu Pro Val Lys Trp Met Ala Leu Glu Ser Leu Gln Thr Gln Lys 
    290                 295                 300                 


Phe Thr Thr Lys Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu 
305                 310                 315                 320 


Leu Met Thr Arg Gly Ala Pro Pro Tyr Pro Asp Val Asn Thr Phe Asp 
                325                 330                 335     


Ile Thr Val Tyr Leu Leu Gln Gly Arg Arg Leu Leu Gln Pro Glu Tyr 
            340                 345                 350         


Cys Pro Asp Pro Leu Tyr Glu Val Met Leu Lys Cys Trp His Pro Lys 
        355                 360                 365             


Ala Glu Met Arg Pro Ser Phe Ser Glu Leu Val Ser Arg Ile Ser Ala 
    370                 375                 380                 


Ile Phe Ser Thr Phe Ile Gly Glu His Tyr Val His Val Asn Ala Thr 
385                 390                 395                 400 


Tyr Val Asn Val Lys Cys Val Ala Pro Tyr Pro Ser Leu Leu Ser Ser 
                405                 410                 415     


Glu Asp Asn Ala Asp Asp Glu Val Asp Thr Arg Pro Ala Ser Phe Trp 
            420                 425                 430         


Glu Thr Ser 
        435 


<210> 114
<211> 425
<212> PRT
<213> Homo sapiens

<400> 114
Lys Met Lys Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala 
1               5                   10                  15      


Val His Lys Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val 
            20                  25                  30          


Ser Ala Asp Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg 
        35                  40                  45              


Pro Ser Arg Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser 
    50                  55                  60                  


Glu Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg 
65                  70                  75                  80  


Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
                85                  90                  95      


Leu Ala Glu Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr 
            100                 105                 110         


Lys Val Ala Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu 
        115                 120                 125             


Ser Asp Leu Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
    130                 135                 140                 


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
145                 150                 155                 160 


Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
                165                 170                 175     


Gln Ala Arg Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His 
            180                 185                 190         


Asn Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr 
        195                 200                 205             


Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His 
    210                 215                 220                 


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met 
225                 230                 235                 240 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr 
                245                 250                 255     


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
            260                 265                 270         


Glu Ala Leu Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser 
        275                 280                 285             


Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
    290                 295                 300                 


Pro Gly Val Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
305                 310                 315                 320 


Arg Met Asp Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                325                 330                 335     


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
            340                 345                 350         


Leu Val Glu Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu 
        355                 360                 365             


Tyr Leu Asp Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro 
    370                 375                 380                 


Asp Thr Arg Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser 
385                 390                 395                 400 


His Glu Pro Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln 
                405                 410                 415     


Leu Ala Asn Gly Gly Leu Lys Arg Arg 
            420                 425 


<210> 115
<211> 423
<212> PRT
<213> Homo sapiens

<400> 115
Arg Met Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala 
1               5                   10                  15      


Val His Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val 
            20                  25                  30          


Ser Ala Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg 
        35                  40                  45              


Ile Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly 
    50                  55                  60                  


Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg 
65                  70                  75                  80  


Asp Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
                85                  90                  95      


Val Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu 
            100                 105                 110         


Ala Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys 
        115                 120                 125             


Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly 
    130                 135                 140                 


Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly 
145                 150                 155                 160 


Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu 
                165                 170                 175     


Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile 
            180                 185                 190         


Asn Arg Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys 
        195                 200                 205             


Thr Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys 
    210                 215                 220                 


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn 
225                 230                 235                 240 


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile 
                245                 250                 255     


Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met 
            260                 265                 270         


Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
        275                 280                 285             


Trp Ser Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser 
    290                 295                 300                 


Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu 
305                 310                 315                 320 


Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met 
                325                 330                 335     


Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe 
            340                 345                 350         


Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn 
        355                 360                 365             


Glu Glu Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser 
    370                 375                 380                 


Tyr Pro Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe 
385                 390                 395                 400 


Ser Pro Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His 
                405                 410                 415     


Ile Asn Gly Ser Val Lys Thr 
            420             


<210> 116
<211> 410
<212> PRT
<213> Homo sapiens

<400> 116
Arg Leu Arg Ser Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His 
1               5                   10                  15      


Lys Ile Ser Arg Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn 
            20                  25                  30          


Ala Ser Met Ser Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser 
        35                  40                  45              


Ser Gly Glu Gly Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro 
    50                  55                  60                  


Ala Asp Pro Lys Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys 
65                  70                  75                  80  


Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile 
                85                  90                  95      


Gly Ile Asp Lys Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys 
            100                 105                 110         


Met Leu Lys Asp Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser 
        115                 120                 125             


Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
    130                 135                 140                 


Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu 
145                 150                 155                 160 


Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro 
                165                 170                 175     


Pro Gly Leu Asp Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln 
            180                 185                 190         


Leu Thr Phe Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly 
        195                 200                 205             


Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala 
    210                 215                 220                 


Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe 
225                 230                 235                 240 


Gly Leu Ala Arg Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr 
                245                 250                 255     


Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
            260                 265                 270         


Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
        275                 280                 285             


Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val 
    290                 295                 300                 


Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
305                 310                 315                 320 


Ala Asn Cys Thr His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His 
                325                 330                 335     


Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
            340                 345                 350         


Asp Arg Val Leu Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser 
        355                 360                 365             


Ala Pro Phe Glu Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser 
    370                 375                 380                 


Ser Ser Ser Gly Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro 
385                 390                 395                 400 


Ala Pro Pro Ser Ser Gly Gly Ser Arg Thr 
                405                 410 


<210> 117
<211> 412
<212> PRT
<213> Homo sapiens

<400> 117
Arg Gly Gln Ala Leu His Gly Arg His Pro Arg Pro Pro Ala Thr Val 
1               5                   10                  15      


Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg Gln Phe Ser Leu Glu Ser 
            20                  25                  30          


Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu Val Arg Gly Val Arg Leu 
        35                  40                  45              


Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly Leu Val Ser Leu Asp Leu 
    50                  55                  60                  


Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg Leu Val Leu Gly 
65                  70                  75                  80  


Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Arg Ala Glu Ala 
                85                  90                  95      


Phe Gly Met Asp Pro Ala Arg Pro Asp Gln Ala Ser Thr Val Ala Val 
            100                 105                 110         


Lys Met Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu Ala Asp Leu Val 
        115                 120                 125             


Ser Glu Met Glu Val Met Lys Leu Ile Gly Arg His Lys Asn Ile Ile 
    130                 135                 140                 


Asn Leu Leu Gly Val Cys Thr Gln Glu Gly Pro Leu Tyr Val Ile Val 
145                 150                 155                 160 


Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg 
                165                 170                 175     


Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg Ser Ser Glu Gly 
            180                 185                 190         


Pro Leu Ser Phe Pro Val Leu Val Ser Cys Ala Tyr Gln Val Ala Arg 
        195                 200                 205             


Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys Ile His Arg Asp Leu Ala 
    210                 215                 220                 


Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp 
225                 230                 235                 240 


Phe Gly Leu Ala Arg Gly Val His His Ile Asp Tyr Tyr Lys Lys Thr 
                245                 250                 255     


Ser Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe 
            260                 265                 270         


Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Ile Leu 
        275                 280                 285             


Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro 
    290                 295                 300                 


Val Glu Glu Leu Phe Ser Leu Leu Arg Glu Gly His Arg Met Asp Arg 
305                 310                 315                 320 


Pro Pro His Cys Pro Pro Glu Leu Tyr Gly Leu Met Arg Glu Cys Trp 
                325                 330                 335     


His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Ala 
            340                 345                 350         


Leu Asp Lys Val Leu Leu Ala Val Ser Glu Glu Tyr Leu Asp Leu Arg 
        355                 360                 365             


Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly Gly Asp Ala Ser Ser Thr 
    370                 375                 380                 


Cys Ser Ser Ser Asp Ser Val Phe Ser His Asp Pro Leu Pro Leu Gly 
385                 390                 395                 400 


Ser Ser Ser Phe Pro Phe Gly Ser Gly Val Gln Thr 
                405                 410         


<210> 118
<211> 571
<212> PRT
<213> Homo sapiens

<400> 118
Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly Tyr 
1               5                   10                  15      


Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His Cys 
            20                  25                  30          


Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp Arg 
        35                  40                  45              


Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val Ile 
    50                  55                  60                  


Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr Val 
65                  70                  75                  80  


Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg Ala 
                85                  90                  95      


Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu Asn 
            100                 105                 110         


Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu Met 
        115                 120                 125             


Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu Arg 
    130                 135                 140                 


Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg Phe 
145                 150                 155                 160 


Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys Arg 
                165                 170                 175     


Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly Phe 
            180                 185                 190         


Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro Glu 
        195                 200                 205             


Asp Leu Tyr Lys Asp Phe Leu Thr Leu Glu His Leu Ile Cys Tyr Ser 
    210                 215                 220                 


Phe Gln Val Ala Lys Gly Met Glu Phe Leu Ala Ser Arg Lys Cys Ile 
225                 230                 235                 240 


His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Ser Glu Lys Asn Val 
                245                 250                 255     


Val Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro 
            260                 265                 270         


Asp Tyr Val Arg Lys Gly Asp Ala Arg Leu Pro Leu Lys Trp Met Ala 
        275                 280                 285             


Pro Glu Thr Ile Phe Asp Arg Val Tyr Thr Ile Gln Ser Asp Val Trp 
    290                 295                 300                 


Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro 
305                 310                 315                 320 


Tyr Pro Gly Val Lys Ile Asp Glu Glu Phe Cys Arg Arg Leu Lys Glu 
                325                 330                 335     


Gly Thr Arg Met Arg Ala Pro Asp Tyr Thr Thr Pro Glu Met Tyr Gln 
            340                 345                 350         


Thr Met Leu Asp Cys Trp His Gly Glu Pro Ser Gln Arg Pro Thr Phe 
        355                 360                 365             


Ser Glu Leu Val Glu His Leu Gly Asn Leu Leu Gln Ala Asn Ala Gln 
    370                 375                 380                 


Gln Asp Gly Lys Asp Tyr Ile Val Leu Pro Ile Ser Glu Thr Leu Ser 
385                 390                 395                 400 


Met Glu Glu Asp Ser Gly Leu Ser Leu Pro Thr Ser Pro Val Ser Cys 
                405                 410                 415     


Met Glu Glu Glu Glu Val Cys Asp Pro Lys Phe His Tyr Asp Asn Thr 
            420                 425                 430         


Ala Gly Ile Ser Gln Tyr Leu Gln Asn Ser Lys Arg Lys Ser Arg Pro 
        435                 440                 445             


Val Ser Val Lys Thr Phe Glu Asp Ile Pro Leu Glu Glu Pro Glu Val 
    450                 455                 460                 


Lys Val Ile Pro Asp Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala 
465                 470                 475                 480 


Ser Glu Glu Leu Lys Thr Leu Glu Asp Arg Thr Lys Leu Ser Pro Ser 
                485                 490                 495     


Phe Gly Gly Met Val Pro Ser Lys Ser Arg Glu Ser Val Ala Ser Glu 
            500                 505                 510         


Gly Ser Asn Gln Thr Ser Gly Tyr Gln Ser Gly Tyr His Ser Asp Asp 
        515                 520                 525             


Thr Asp Thr Thr Val Tyr Ser Ser Glu Glu Ala Glu Leu Leu Lys Leu 
    530                 535                 540                 


Ile Glu Ile Gly Val Gln Thr Gly Ser Thr Ala Gln Ile Leu Gln Pro 
545                 550                 555                 560 


Asp Ser Gly Thr Thr Leu Ser Ser Pro Pro Val 
                565                 570     


<210> 119
<211> 567
<212> PRT
<213> Homo sapiens

<400> 119
Phe Cys Asn Met Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr 
1               5                   10                  15      


Leu Ser Ile Ile Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys 
            20                  25                  30          


Glu Tyr Leu Ser Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg 
        35                  40                  45              


Leu His Leu Gly Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val 
    50                  55                  60                  


Glu Ala Ser Ala Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val 
65                  70                  75                  80  


Ala Val Lys Met Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala 
                85                  90                  95      


Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn 
            100                 105                 110         


Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met 
        115                 120                 125             


Val Ile Val Glu Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg 
    130                 135                 140                 


Ala Lys Arg Asp Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln 
145                 150                 155                 160 


Arg Gly Arg Phe Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg 
                165                 170                 175     


Arg Pro Gly Ser Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr 
            180                 185                 190         


Glu Gly Gly Ala Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu 
        195                 200                 205             


Trp Leu Ser Pro Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln 
    210                 215                 220                 


Val Ala Arg Gly Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg 
225                 230                 235                 240 


Asp Leu Ala Ala Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys 
                245                 250                 255     


Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr 
            260                 265                 270         


Val Arg Lys Gly Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu 
        275                 280                 285             


Ser Ile Phe Asp Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe 
    290                 295                 300                 


Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro 
305                 310                 315                 320 


Gly Val Gln Ile Asn Glu Glu Phe Cys Gln Arg Leu Arg Asp Gly Thr 
                325                 330                 335     


Arg Met Arg Ala Pro Glu Leu Ala Thr Pro Ala Ile Arg Arg Ile Met 
            340                 345                 350         


Leu Asn Cys Trp Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Glu 
        355                 360                 365             


Leu Val Glu Ile Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu 
    370                 375                 380                 


Glu Glu Glu Val Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu 
385                 390                 395                 400 


Gly Ser Phe Ser Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala 
                405                 410                 415     


Asp Ala Glu Asp Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala 
            420                 425                 430         


Arg Tyr Tyr Asn Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala 
        435                 440                 445             


Glu Thr Arg Gly Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met 
    450                 455                 460                 


Thr Pro Thr Thr Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly 
465                 470                 475                 480 


Met Val Leu Ala Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg 
                485                 490                 495     


Gln Glu Ser Gly Phe Ser Cys Lys Gly Pro Gly Gln Asn Val Ala Val 
            500                 505                 510         


Thr Arg Ala His Pro Asp Ser Gln Gly Arg Arg Arg Arg Pro Glu Arg 
        515                 520                 525             


Gly Ala Arg Gly Gly Gln Val Phe Tyr Asn Ser Glu Tyr Gly Glu Leu 
    530                 535                 540                 


Ser Glu Pro Ser Glu Glu Asp His Cys Ser Pro Ser Ala Arg Val Thr 
545                 550                 555                 560 


Phe Phe Thr Asp Asn Ser Tyr 
                565         


<210> 120
<211> 408
<212> PRT
<213> Homo sapiens

<400> 120
Arg Ser Arg Arg Ala Gln Arg Gln Arg Gln Gln Arg Gln Arg Asp Arg 
1               5                   10                  15      


Ala Thr Asp Val Asp Arg Glu Asp Lys Leu Trp Leu Lys Pro Tyr Val 
            20                  25                  30          


Asp Leu Gln Ala Tyr Glu Asp Pro Ala Gln Gly Ala Leu Asp Phe Thr 
        35                  40                  45              


Arg Glu Leu Asp Pro Ala Trp Leu Met Val Asp Thr Val Ile Gly Glu 
    50                  55                  60                  


Gly Glu Phe Gly Glu Val Tyr Arg Gly Thr Leu Arg Leu Pro Ser Gln 
65                  70                  75                  80  


Asp Cys Lys Thr Val Ala Ile Lys Thr Leu Lys Asp Thr Ser Pro Gly 
                85                  90                  95      


Gly Gln Trp Trp Asn Phe Leu Arg Glu Ala Thr Ile Met Gly Gln Phe 
            100                 105                 110         


Ser His Pro His Ile Leu His Leu Glu Gly Val Val Thr Lys Arg Lys 
        115                 120                 125             


Pro Ile Met Ile Ile Thr Glu Phe Met Glu Asn Gly Ala Leu Asp Ala 
    130                 135                 140                 


Phe Leu Arg Glu Arg Glu Asp Gln Leu Val Pro Gly Gln Leu Val Ala 
145                 150                 155                 160 


Met Leu Gln Gly Ile Ala Ser Gly Met Asn Tyr Leu Ser Asn His Asn 
                165                 170                 175     


Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Gln Asn 
            180                 185                 190         


Leu Cys Cys Lys Val Ser Asp Phe Gly Leu Thr Arg Leu Leu Asp Asp 
        195                 200                 205             


Phe Asp Gly Thr Tyr Glu Thr Gln Gly Gly Lys Ile Pro Ile Arg Trp 
    210                 215                 220                 


Thr Ala Pro Glu Ala Ile Ala His Arg Ile Phe Thr Thr Ala Ser Asp 
225                 230                 235                 240 


Val Trp Ser Phe Gly Ile Val Met Trp Glu Val Leu Ser Phe Gly Asp 
                245                 250                 255     


Lys Pro Tyr Gly Glu Met Ser Asn Gln Glu Val Met Lys Ser Ile Glu 
            260                 265                 270         


Asp Gly Tyr Arg Leu Pro Pro Pro Val Asp Cys Pro Ala Pro Leu Tyr 
        275                 280                 285             


Glu Leu Met Lys Asn Cys Trp Ala Tyr Asp Arg Ala Arg Arg Pro His 
    290                 295                 300                 


Phe Gln Lys Leu Gln Ala His Leu Glu Gln Leu Leu Ala Asn Pro His 
305                 310                 315                 320 


Ser Leu Arg Thr Ile Ala Asn Phe Asp Pro Arg Met Thr Leu Arg Leu 
                325                 330                 335     


Pro Ser Leu Ser Gly Ser Asp Gly Ile Pro Tyr Arg Thr Val Ser Glu 
            340                 345                 350         


Trp Leu Glu Ser Ile Arg Met Lys Arg Tyr Ile Leu His Phe His Ser 
        355                 360                 365             


Ala Gly Leu Asp Thr Met Glu Cys Val Leu Glu Leu Thr Ala Glu Asp 
    370                 375                 380                 


Leu Thr Gln Met Gly Ile Thr Leu Pro Gly His Gln Lys Arg Ile Leu 
385                 390                 395                 400 


Cys Ser Ile Gln Gly Phe Lys Asp 
                405             


<210> 121
<211> 421
<212> PRT
<213> Homo sapiens

<400> 121
Ser Arg Lys Arg Ala Tyr Ser Lys Glu Ala Val Tyr Ser Asp Lys Leu 
1               5                   10                  15      


Gln His Tyr Ser Thr Gly Arg Gly Ser Pro Gly Met Lys Ile Tyr Ile 
            20                  25                  30          


Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe Ala 
        35                  40                  45              


Lys Glu Ile Asp Val Ser Phe Val Lys Ile Glu Glu Val Ile Gly Ala 
    50                  55                  60                  


Gly Glu Phe Gly Glu Val Tyr Lys Gly Arg Leu Lys Leu Pro Gly Lys 
65                  70                  75                  80  


Arg Glu Ile Tyr Val Ala Ile Lys Thr Leu Lys Ala Gly Tyr Ser Glu 
                85                  90                  95      


Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met Gly Gln Phe 
            100                 105                 110         


Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Lys Ser Arg 
        115                 120                 125             


Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn Gly Ala Leu Asp Ser 
    130                 135                 140                 


Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly 
145                 150                 155                 160 


Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Glu Met Asn 
                165                 170                 175     


Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn 
            180                 185                 190         


Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Tyr Leu Gln Asp 
        195                 200                 205             


Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile Pro 
    210                 215                 220                 


Val Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys Phe Thr Ser 
225                 230                 235                 240 


Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser 
                245                 250                 255     


Phe Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Asn 
            260                 265                 270         


Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp Cys Pro Ala 
        275                 280                 285             


Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp Arg Asn Ser 
    290                 295                 300                 


Arg Pro Arg Phe Ala Glu Ile Val Asn Thr Leu Asp Lys Met Ile Arg 
305                 310                 315                 320 


Asn Pro Ala Ser Leu Lys Thr Val Ala Thr Ile Thr Ala Val Pro Ser 
                325                 330                 335     


Gln Pro Leu Leu Asp Arg Ser Ile Pro Asp Phe Thr Ala Phe Thr Thr 
            340                 345                 350         


Val Asp Asp Trp Leu Ser Ala Ile Lys Met Val Gln Tyr Arg Asp Ser 
        355                 360                 365             


Phe Leu Thr Ala Gly Phe Thr Ser Leu Gln Leu Val Thr Gln Met Thr 
    370                 375                 380                 


Ser Glu Asp Leu Leu Arg Ile Gly Ile Thr Leu Ala Gly His Gln Lys 
385                 390                 395                 400 


Lys Ile Leu Asn Ser Ile His Ser Met Arg Val Gln Ile Ser Gln Ser 
                405                 410                 415     


Pro Thr Ala Met Ala 
            420     


<210> 122
<211> 540
<212> PRT
<213> Homo sapiens

<400> 122
Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg Val Ile Glu Ser Ile 
1               5                   10                  15      


Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro 
            20                  25                  30          


Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly Leu Val Leu Gly Arg 
        35                  40                  45              


Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val Glu Gly Thr Ala Tyr 
    50                  55                  60                  


Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val Ala Val Lys Met Leu 
65                  70                  75                  80  


Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu 
                85                  90                  95      


Lys Ile Met Thr His Leu Gly Pro His Leu Asn Ile Val Asn Leu Leu 
            100                 105                 110         


Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys 
        115                 120                 125             


Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys Asn Arg Asp Ser Phe 
    130                 135                 140                 


Leu Ser His His Pro Glu Lys Pro Lys Lys Glu Leu Asp Ile Phe Gly 
145                 150                 155                 160 


Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr Val Ile Leu Ser Phe 
                165                 170                 175     


Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln Ala Asp Thr Thr Gln 
            180                 185                 190         


Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser Lys Tyr Ser Asp Ile 
        195                 200                 205             


Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr Lys Lys Lys Ser Met 
    210                 215                 220                 


Leu Asp Ser Glu Val Lys Asn Leu Leu Ser Asp Asp Asn Ser Glu Gly 
225                 230                 235                 240 


Leu Thr Leu Leu Asp Leu Leu Ser Phe Thr Tyr Gln Val Ala Arg Gly 
                245                 250                 255     


Met Glu Phe Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala 
            260                 265                 270         


Arg Asn Val Leu Leu Ala Gln Gly Lys Ile Val Lys Ile Cys Asp Phe 
        275                 280                 285             


Gly Leu Ala Arg Asp Ile Met His Asp Ser Asn Tyr Val Ser Lys Gly 
    290                 295                 300                 


Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp 
305                 310                 315                 320 


Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu 
                325                 330                 335     


Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr Pro Gly Met Met Val 
            340                 345                 350         


Asp Ser Thr Phe Tyr Asn Lys Ile Lys Ser Gly Tyr Arg Met Ala Lys 
        355                 360                 365             


Pro Asp His Ala Thr Ser Glu Val Tyr Glu Ile Met Val Lys Cys Trp 
    370                 375                 380                 


Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Tyr His Leu Ser Glu Ile 
385                 390                 395                 400 


Val Glu Asn Leu Leu Pro Gly Gln Tyr Lys Lys Ser Tyr Glu Lys Ile 
                405                 410                 415     


His Leu Asp Phe Leu Lys Ser Asp His Pro Ala Val Ala Arg Met Arg 
            420                 425                 430         


Val Asp Ser Asp Asn Ala Tyr Ile Gly Val Thr Tyr Lys Asn Glu Glu 
        435                 440                 445             


Asp Lys Leu Lys Asp Trp Glu Gly Gly Leu Asp Glu Gln Arg Leu Ser 
    450                 455                 460                 


Ala Asp Ser Gly Tyr Ile Ile Pro Leu Pro Asp Ile Asp Pro Val Pro 
465                 470                 475                 480 


Glu Glu Glu Asp Leu Gly Lys Arg Asn Arg His Ser Ser Gln Thr Ser 
                485                 490                 495     


Glu Glu Ser Ala Ile Glu Thr Gly Ser Ser Ser Ser Thr Phe Ile Lys 
            500                 505                 510         


Arg Glu Asp Glu Thr Ile Glu Asp Ile Asp Met Met Asp Asp Ile Gly 
        515                 520                 525             


Ile Asp Ser Ser Asp Leu Val Glu Asp Ser Phe Leu 
    530                 535                 540 


<210> 123
<211> 553
<212> PRT
<213> Homo sapiens

<400> 123
Met Leu Trp Gln Lys Lys Pro Arg Tyr Glu Ile Arg Trp Lys Val Ile 
1               5                   10                  15      


Glu Ser Val Ser Ser Asp Gly His Glu Tyr Ile Tyr Val Asp Pro Met 
            20                  25                  30          


Gln Leu Pro Tyr Asp Ser Thr Trp Glu Leu Pro Arg Asp Gln Leu Val 
        35                  40                  45              


Leu Gly Arg Thr Leu Gly Ser Gly Ala Phe Gly Gln Val Val Glu Ala 
    50                  55                  60                  


Thr Ala His Gly Leu Ser His Ser Gln Ala Thr Met Lys Val Ala Val 
65                  70                  75                  80  


Lys Met Leu Lys Ser Thr Ala Arg Ser Ser Glu Lys Gln Ala Leu Met 
                85                  90                  95      


Ser Glu Leu Lys Ile Met Ser His Leu Gly Pro His Leu Asn Val Val 
            100                 105                 110         


Asn Leu Leu Gly Ala Cys Thr Lys Gly Gly Pro Ile Tyr Ile Ile Thr 
        115                 120                 125             


Glu Tyr Cys Arg Tyr Gly Asp Leu Val Asp Tyr Leu His Arg Asn Lys 
    130                 135                 140                 


His Thr Phe Leu Gln His His Ser Asp Lys Arg Arg Pro Pro Ser Ala 
145                 150                 155                 160 


Glu Leu Tyr Ser Asn Ala Leu Pro Val Gly Leu Pro Leu Pro Ser His 
                165                 170                 175     


Val Ser Leu Thr Gly Glu Ser Asp Gly Gly Tyr Met Asp Met Ser Lys 
            180                 185                 190         


Asp Glu Ser Val Asp Tyr Val Pro Met Leu Asp Met Lys Gly Asp Val 
        195                 200                 205             


Lys Tyr Ala Asp Ile Glu Ser Ser Asn Tyr Met Ala Pro Tyr Asp Asn 
    210                 215                 220                 


Tyr Val Pro Ser Ala Pro Glu Arg Thr Cys Arg Ala Thr Leu Ile Asn 
225                 230                 235                 240 


Glu Ser Pro Val Leu Ser Tyr Met Asp Leu Val Gly Phe Ser Tyr Gln 
                245                 250                 255     


Val Ala Asn Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His Arg 
            260                 265                 270         


Asp Leu Ala Ala Arg Asn Val Leu Ile Cys Glu Gly Lys Leu Val Lys 
        275                 280                 285             


Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Met Arg Asp Ser Asn Tyr 
    290                 295                 300                 


Ile Ser Lys Gly Ser Thr Phe Leu Pro Leu Lys Trp Met Ala Pro Glu 
305                 310                 315                 320 


Ser Ile Phe Asn Ser Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser Phe 
                325                 330                 335     


Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Thr Pro Tyr Pro 
            340                 345                 350         


Glu Leu Pro Met Asn Glu Gln Phe Tyr Asn Ala Ile Lys Arg Gly Tyr 
        355                 360                 365             


Arg Met Ala Gln Pro Ala His Ala Ser Asp Glu Ile Tyr Glu Ile Met 
    370                 375                 380                 


Gln Lys Cys Trp Glu Glu Lys Phe Glu Ile Arg Pro Pro Phe Ser Gln 
385                 390                 395                 400 


Leu Val Leu Leu Leu Glu Arg Leu Leu Gly Glu Gly Tyr Lys Lys Lys 
                405                 410                 415     


Tyr Gln Gln Val Asp Glu Glu Phe Leu Arg Ser Asp His Pro Ala Ile 
            420                 425                 430         


Leu Arg Ser Gln Ala Arg Leu Pro Gly Phe His Gly Leu Arg Ser Pro 
        435                 440                 445             


Leu Asp Thr Ser Ser Val Leu Tyr Thr Ala Val Gln Pro Asn Glu Gly 
    450                 455                 460                 


Asp Asn Asp Tyr Ile Ile Pro Leu Pro Asp Pro Lys Pro Glu Val Ala 
465                 470                 475                 480 


Asp Glu Gly Pro Leu Glu Gly Ser Pro Ser Leu Ala Ser Ser Thr Leu 
                485                 490                 495     


Asn Glu Val Asn Thr Ser Ser Thr Ile Ser Cys Asp Ser Pro Leu Glu 
            500                 505                 510         


Pro Gln Asp Glu Pro Glu Pro Glu Pro Gln Leu Glu Leu Gln Val Glu 
        515                 520                 525             


Pro Glu Pro Glu Leu Glu Gln Leu Pro Asp Ser Gly Cys Pro Ala Pro 
    530                 535                 540                 


Arg Ala Glu Ala Glu Asp Ser Phe Leu 
545                 550             


<210> 124
<211> 61
<212> PRT
<213> Homo sapiens

<400> 124
Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu Asp Ala Gly Asp Glu 
1               5                   10                  15      


Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser 
            20                  25                  30          


Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr Gln Asp Val 
        35                  40                  45              


Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu Lys Pro 
    50                  55                  60      


<210> 125
<211> 49
<212> PRT
<213> Homo sapiens

<400> 125
Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu Asp His Thr Tyr 
1               5                   10                  15      


Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu Asp Ile Val Thr 
            20                  25                  30          


Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu His Pro Gly Gln 
        35                  40                  45              


Glu 
    


<210> 126
<211> 52
<212> PRT
<213> Homo sapiens

<400> 126
Lys Arg Ala Val Ser Thr Pro Ser Asn Glu Gly Ala Ile Ile Phe Leu 
1               5                   10                  15      


Pro Pro Trp Leu Phe Ser Arg Arg Arg Arg Leu Glu Arg Met Ser Arg 
            20                  25                  30          


Gly Arg Glu Lys Cys Tyr Ser Ser Pro Gly Tyr Pro Gln Glu Ser Ser 
        35                  40                  45              


Asn Gln Phe His 
    50          


<210> 127
<211> 61
<212> PRT
<213> Homo sapiens

<400> 127
Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr Glu Ser Trp 
1               5                   10                  15      


Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile Ser Thr Ser 
            20                  25                  30          


Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp Ile Tyr Val 
        35                  40                  45              


Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
    50                  55                  60      


<210> 128
<211> 39
<212> PRT
<213> Homo sapiens

<400> 128
Arg Leu Gln Ser Ile Phe Pro Asp Phe Ser Lys Ala Gly Met Glu Arg 
1               5                   10                  15      


Ala Phe Leu Pro Val Thr Ser Pro Asn Lys His Leu Gly Leu Val Thr 
            20                  25                  30          


Pro His Lys Thr Glu Leu Val 
        35                  


<210> 129
<211> 38
<212> PRT
<213> Homo sapiens

<400> 129
Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210> 130
<211> 29
<212> PRT
<213> Homo sapiens

<400> 130
Asn Arg Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys 
1               5                   10                  15      


Gly Thr Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro 
            20                  25                  


<210> 131
<211> 27
<212> PRT
<213> Homo sapiens

<400> 131
Gly Gln His Leu Arg Gln Gln Arg Met Gly Thr Tyr Gly Val Arg Ala 
1               5                   10                  15      


Ala Trp Arg Arg Leu Pro Gln Ala Phe Arg Pro 
            20                  25          


<210> 132
<211> 37
<212> PRT
<213> Homo sapiens

<400> 132
Arg Glu His Gln Arg Ser Gly Ser Tyr His Val Arg Glu Glu Ser Thr 
1               5                   10                  15      


Tyr Leu Pro Leu Thr Ser Met Gln Pro Thr Glu Ala Met Gly Glu Glu 
            20                  25                  30          


Pro Ser Arg Ala Glu 
        35          


<210> 133
<211> 114
<212> PRT
<213> Homo sapiens

<400> 133
Arg Trp Cys Ser Lys Lys Lys Asp Ala Ala Val Met Asn Gln Glu Pro 
1               5                   10                  15      


Ala Gly His Arg Thr Val Asn Arg Glu Asp Ser Asp Glu Gln Asp Pro 
            20                  25                  30          


Gln Glu Val Thr Tyr Ala Gln Leu Asp His Cys Ile Phe Thr Gln Arg 
        35                  40                  45              


Lys Ile Thr Gly Pro Ser Gln Arg Ser Lys Arg Pro Ser Thr Asp Thr 
    50                  55                  60                  


Ser Val Cys Ile Glu Leu Pro Asn Ala Glu Pro Arg Ala Leu Ser Pro 
65                  70                  75                  80  


Ala His Glu His His Ser Gln Ala Leu Met Gly Ser Ser Arg Glu Thr 
                85                  90                  95      


Thr Ala Leu Ser Gln Thr Gln Leu Ala Ser Ser Asn Val Pro Ala Ala 
            100                 105                 110         


Gly Ile 
        


<210> 134
<211> 40
<212> PRT
<213> Homo sapiens

<400> 134
Leu His Arg Trp Cys Ser Asp Lys Lys Asn Ala Ala Val Met Asp Gln 
1               5                   10                  15      


Glu Pro Ala Gly Asn Arg Thr Val Asn Ser Glu Asp Ser Asp Glu Gln 
            20                  25                  30          


Asp His Gln Glu Val Ser Tyr Ala 
        35                  40  


<210> 135
<211> 39
<212> PRT
<213> Homo sapiens

<400> 135
His Arg Trp Cys Ser Asn Lys Lys Asn Ala Ala Val Met Asp Gln Glu 
1               5                   10                  15      


Pro Ala Gly Asn Arg Thr Val Asn Ser Glu Asp Ser Asp Glu Gln Asp 
            20                  25                  30          


His Gln Glu Val Ser Tyr Ala 
        35                  


<210> 136
<211> 40
<212> PRT
<213> Homo sapiens

<400> 136
Leu His Arg Trp Cys Ser Asp Lys Lys Asn Ala Ser Val Met Asp Gln 
1               5                   10                  15      


Gly Pro Ala Gly Asn Arg Thr Val Asn Arg Glu Asp Ser Asp Glu Gln 
            20                  25                  30          


Asp His Gln Glu Val Ser Tyr Ala 
        35                  40  


<210> 137
<211> 39
<212> PRT
<213> Homo sapiens

<400> 137
His Arg Trp Cys Ser Asp Lys Lys Asn Ala Ala Val Met Asp Gln Glu 
1               5                   10                  15      


Pro Ala Gly Asn Arg Thr Val Asn Ser Glu Asp Ser Asp Glu Gln Asp 
            20                  25                  30          


His Gln Glu Val Ser Tyr Ala 
        35                  


<210> 138
<211> 40
<212> PRT
<213> Homo sapiens

<400> 138
Leu His Arg Trp Cys Ser Asn Lys Lys Asn Ala Ser Val Met Asp Gln 
1               5                   10                  15      


Gly Pro Ala Gly Asn Arg Thr Val Asn Arg Glu Asp Ser Asp Glu Gln 
            20                  25                  30          


Asp His Gln Glu Val Ser Tyr Ala 
        35                  40  


<210> 139
<211> 22
<212> PRT
<213> Homo sapiens

<400> 139
His Arg Trp Cys Ser Asn Lys Lys Lys Cys Cys Cys Asn Gly Pro Arg 
1               5                   10                  15      


Ala Cys Arg Glu Gln Lys 
            20          


<210> 140
<211> 25
<212> PRT
<213> Homo sapiens

<400> 140
Arg Lys Arg Thr Arg Glu Arg Ala Ser Arg Ala Ser Thr Trp Glu Gly 
1               5                   10                  15      


Arg Arg Arg Leu Asn Thr Gln Thr Leu 
            20                  25  


<210> 141
<211> 63
<212> PRT
<213> Homo sapiens

<400> 141
Trp Trp Gly Asp Ile Trp Trp Lys Thr Met Met Glu Leu Arg Ser Leu 
1               5                   10                  15      


Asp Thr Gln Lys Ala Thr Cys His Leu Gln Gln Val Thr Asp Leu Pro 
            20                  25                  30          


Trp Thr Ser Val Ser Ser Pro Val Glu Arg Glu Ile Leu Tyr His Thr 
        35                  40                  45              


Val Ala Arg Thr Lys Ile Ser Asp Asp Asp Asp Glu His Thr Leu 
    50                  55                  60              


<210> 142
<211> 45
<212> PRT
<213> Homo sapiens

<400> 142
Gly Ser Thr Val Tyr Tyr Gln Gly Lys Cys Leu Thr Trp Lys Gly Pro 
1               5                   10                  15      


Arg Arg Gln Leu Pro Ala Val Val Pro Ala Pro Leu Pro Pro Pro Cys 
            20                  25                  30          


Gly Ser Ser Ala His Leu Leu Pro Pro Val Pro Gly Gly 
        35                  40                  45  


<210> 143
<211> 39
<212> PRT
<213> Homo sapiens

<400> 143
Arg Thr Gln Ile Lys Lys Leu Cys Ser Trp Arg Asp Lys Asn Ser Ala 
1               5                   10                  15      


Ala Cys Val Val Tyr Glu Asp Met Ser His Ser Arg Cys Asn Thr Leu 
            20                  25                  30          


Ser Ser Pro Asn Gln Tyr Gln 
        35                  


<210> 144
<211> 40
<212> PRT
<213> Homo sapiens

<400> 144
Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln 
1               5                   10                  15      


Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg 
            20                  25                  30          


Phe Gln Lys Thr Cys Ser Pro Ile 
        35                  40  


<210> 145
<211> 41
<212> PRT
<213> Homo sapiens

<400> 145
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210> 146
<211> 111
<212> PRT
<213> Homo sapiens

<400> 146
Phe Trp Gly Arg Arg Ser Cys Gln Gln Arg Asp Ser Gly Asn Ser Pro 
1               5                   10                  15      


Gly Asn Ala Phe Tyr Ser Asn Val Leu Tyr Arg Pro Arg Gly Ala Pro 
            20                  25                  30          


Lys Lys Ser Glu Asp Cys Ser Gly Glu Gly Lys Asp Gln Arg Gly Gln 
        35                  40                  45              


Ser Ile Tyr Ser Thr Ser Phe Pro Gln Pro Ala Pro Arg Gln Pro His 
    50                  55                  60                  


Leu Ala Ser Arg Pro Cys Pro Ser Pro Arg Pro Cys Pro Ser Pro Arg 
65                  70                  75                  80  


Pro Gly His Pro Val Ser Met Val Arg Val Ser Pro Arg Pro Ser Pro 
                85                  90                  95      


Thr Gln Gln Pro Arg Pro Lys Gly Phe Pro Lys Val Gly Glu Glu 
            100                 105                 110     


<210> 147
<211> 68
<212> PRT
<213> Homo sapiens

<400> 147
Ala Phe Tyr Val Gln Ser Thr Ala Cys Lys Lys Gly Glu Tyr Asn Val 
1               5                   10                  15      


Gln Glu Ala Glu Ser Ser Gly Glu Ala Val Cys Leu Asn Gly Ala Gly 
            20                  25                  30          


Gly Gly Ala Gly Gly Ala Ala Gly Ala Glu Gly Gly Pro Glu Ala Ala 
        35                  40                  45              


Gly Gly Ala Ala Glu Ser Pro Ala Glu Gly Glu Val Phe Ala Ile Gln 
    50                  55                  60                  


Leu Thr Ser Ala 
65              


<210> 148
<211> 59
<212> PRT
<213> Homo sapiens

<400> 148
Tyr Lys Val Gly Phe Phe Lys Arg Asn Leu Lys Glu Lys Met Glu Ala 
1               5                   10                  15      


Gly Arg Gly Val Pro Asn Gly Ile Pro Ala Glu Asp Ser Glu Gln Leu 
            20                  25                  30          


Ala Ser Gly Gln Glu Ala Gly Asp Pro Gly Cys Leu Lys Pro Leu His 
        35                  40                  45              


Glu Lys Asp Ser Glu Ser Gly Gly Gly Lys Asp 
    50                  55                  


<210> 149
<211> 46
<212> PRT
<213> Homo sapiens

<400> 149
Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg Arg Phe Glu 
1               5                   10                  15      


Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro Leu Phe Lys 
            20                  25                  30          


Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu Ser 
        35                  40                  45      


<210> 150
<211> 85
<212> PRT
<213> Homo sapiens

<400> 150
Ile Met Lys Leu Arg Lys Ala His Val Ile Trp Lys Lys Glu Asn Glu 
1               5                   10                  15      


Val Ser Glu His Thr Leu Glu Ser Tyr Arg Ser Arg Ser Asn Asn Glu 
            20                  25                  30          


Glu Thr Ser Ser Glu Glu Lys Asn Gly Gln Ser Ser His Pro Met Arg 
        35                  40                  45              


Cys Met Asn Tyr Ile Thr Lys Leu Tyr Ser Glu Ala Lys Thr Lys Arg 
    50                  55                  60                  


Lys Glu Asn Val Gln His Ser Lys Leu Glu Glu Lys His Ile Gln Val 
65                  70                  75                  80  


Pro Glu Ser Ile Val 
                85  


<210> 151
<211> 141
<212> PRT
<213> Homo sapiens

<400> 151
Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu Gln 
1               5                   10                  15      


Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val Arg 
            20                  25                  30          


Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn Pro 
        35                  40                  45              


Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu Met 
    50                  55                  60                  


Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg Pro 
65                  70                  75                  80  


Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys Arg 
                85                  90                  95      


Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu Asp Glu 
            100                 105                 110         


Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu Arg Pro 
        115                 120                 125             


Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
    130                 135                 140     


<210> 152
<211> 15
<212> PRT
<213> Homo sapiens

<400> 152
Thr Arg Cys Gly Gly Pro Gln Gln Ser Arg Ala Glu Arg Pro Gly 
1               5                   10                  15  


<210> 153
<211> 44
<212> PRT
<213> Homo sapiens

<400> 153
Arg Ala Ala Arg Arg Arg Pro Glu His Leu Asp Thr Pro Asp Thr Pro 
1               5                   10                  15      


Pro Arg Ser Gln Ala Gln Glu Ser Asn Tyr Glu Asn Leu Ser Gln Met 
            20                  25                  30          


Asn Pro Arg Ser Pro Pro Ala Thr Met Cys Ser Pro 
        35                  40                  


<210> 154
<211> 26
<212> PRT
<213> Homo sapiens

<400> 154
Leu Leu Arg Val Arg Ser Cys Arg Arg Lys Ala Ala Arg Ala Ala Leu 
1               5                   10                  15      


Gly Met Glu Ala Ala Asp Ala Val Thr Asp 
            20                  25      


<210> 155
<211> 48
<212> PRT
<213> Homo sapiens

<400> 155
Lys Lys Tyr Phe Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe 
1               5                   10                  15      


Ser Ser Leu Gln Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val 
            20                  25                  30          


Gln Ala Glu Asp Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp 
        35                  40                  45              


<210> 156
<211> 185
<212> PRT
<213> Homo sapiens

<400> 156
Ser Tyr Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr 
1               5                   10                  15      


Gln Thr Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg 
            20                  25                  30          


Asn Leu Gln Phe His Ala Phe Ile Ser Tyr Ser Gly His Asp Ser Phe 
        35                  40                  45              


Trp Val Lys Asn Glu Leu Leu Pro Asn Leu Glu Lys Glu Gly Met Gln 
    50                  55                  60                  


Ile Cys Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu 
65                  70                  75                  80  


Asn Ile Ile Thr Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu 
                85                  90                  95      


Ser Pro Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe 
            100                 105                 110         


Ala His His Asn Leu Phe His Glu Gly Ser Asn Ser Leu Ile Leu Ile 
        115                 120                 125             


Leu Leu Glu Pro Ile Pro Gln Tyr Ser Ile Pro Ser Ser Tyr His Lys 
    130                 135                 140                 


Leu Lys Ser Leu Met Ala Arg Arg Thr Tyr Leu Glu Trp Pro Lys Glu 
145                 150                 155                 160 


Lys Ser Lys Arg Gly Leu Phe Trp Ala Asn Leu Arg Ala Ala Ile Asn 
                165                 170                 175     


Ile Lys Leu Thr Glu Gln Ala Lys Lys 
            180                 185 


<210> 157
<211> 214
<212> PRT
<213> Homo sapiens

<400> 157
Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg Met Leu Gly Gln Cys 
1               5                   10                  15      


Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr Gln Glu Gln Leu Lys 
            20                  25                  30          


Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser 
        35                  40                  45              


Leu Trp Val Lys Asn Glu Leu Ile Pro Asn Leu Glu Lys Glu Asp Gly 
    50                  55                  60                  


Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe Asp Pro Gly Lys Ser 
65                  70                  75                  80  


Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys Ser Tyr Lys Ser Ile 
                85                  90                  95      


Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu Trp Cys His Tyr Glu 
            100                 105                 110         


Phe Tyr Phe Ala His His Asn Leu Phe His Glu Asn Ser Asp His Ile 
        115                 120                 125             


Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr Cys Ile Pro Thr Arg 
    130                 135                 140                 


Tyr His Lys Leu Lys Ala Leu Leu Glu Lys Lys Ala Tyr Leu Glu Trp 
145                 150                 155                 160 


Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp Ala Asn Leu Arg Ala 
                165                 170                 175     


Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu Met Tyr Glu Leu Gln 
            180                 185                 190         


Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly Ser Thr Ile Ser Leu 
        195                 200                 205             


Met Arg Thr Asp Cys Leu 
    210                 


<210> 158
<211> 175
<212> PRT
<213> Homo sapiens

<400> 158
His Arg Phe His Gly Leu Trp Tyr Met Lys Met Met Trp Ala Trp Leu 
1               5                   10                  15      


Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile Cys Tyr 
            20                  25                  30          


Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu Asn 
        35                  40                  45              


Leu Met Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu Cys 
    50                  55                  60                  


Leu His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn Ile 
65                  70                  75                  80  


Ile Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser Glu 
                85                  90                  95      


Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser His 
            100                 105                 110         


Phe Arg Leu Phe Asp Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu Leu 
        115                 120                 125             


Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu Arg 
    130                 135                 140                 


Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu Ala 
145                 150                 155                 160 


Gln Arg Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser 
                165                 170                 175 


<210> 159
<211> 179
<212> PRT
<213> Homo sapiens

<400> 159
Glu Gly Trp Arg Ile Ser Phe Tyr Trp Asn Val Ser Val His Arg Val 
1               5                   10                  15      


Leu Gly Phe Lys Glu Ile Asp Arg Gln Thr Glu Gln Phe Glu Tyr Ala 
            20                  25                  30          


Ala Tyr Ile Ile His Ala Tyr Lys Asp Lys Asp Trp Val Trp Glu His 
        35                  40                  45              


Phe Ser Ser Met Glu Lys Glu Asp Gln Ser Leu Lys Phe Cys Leu Glu 
    50                  55                  60                  


Glu Arg Asp Phe Glu Ala Gly Val Phe Glu Leu Glu Ala Ile Val Asn 
65                  70                  75                  80  


Ser Ile Lys Arg Ser Arg Lys Ile Ile Phe Val Ile Thr His His Leu 
                85                  90                  95      


Leu Lys Asp Pro Leu Cys Lys Arg Phe Lys Val His His Ala Val Gln 
            100                 105                 110         


Gln Ala Ile Glu Gln Asn Leu Asp Ser Ile Ile Leu Val Phe Leu Glu 
        115                 120                 125             


Glu Ile Pro Asp Tyr Lys Leu Asn His Ala Leu Cys Leu Arg Arg Gly 
    130                 135                 140                 


Met Phe Lys Ser His Cys Ile Leu Asn Trp Pro Val Gln Lys Glu Arg 
145                 150                 155                 160 


Ile Gly Ala Phe Arg His Lys Leu Gln Val Ala Leu Gly Ser Lys Asn 
                165                 170                 175     


Ser Val His 
            


<210> 160
<211> 187
<212> PRT
<213> Homo sapiens

<400> 160
Lys Phe Tyr Phe His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly 
1               5                   10                  15      


Arg Gly Glu Asn Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp 
            20                  25                  30          


Glu Asp Trp Val Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val 
        35                  40                  45              


Pro Pro Phe Gln Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val 
    50                  55                  60                  


Ala Ile Ala Ala Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys 
65                  70                  75                  80  


Val Ile Val Val Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile 
                85                  90                  95      


Phe Glu Tyr Glu Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala 
            100                 105                 110         


Gly Ile Ile Phe Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg 
        115                 120                 125             


Gln Gln Val Glu Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu 
    130                 135                 140                 


Trp Glu Asp Ser Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg 
145                 150                 155                 160 


Lys Ala Leu Leu Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly 
                165                 170                 175     


Thr Gly Cys Asn Trp Gln Glu Ala Thr Ser Ile 
            180                 185         


<210> 161
<211> 198
<212> PRT
<213> Homo sapiens

<400> 161
Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys Thr Ala Gln Arg 
1               5                   10                  15      


Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro Asp Met Tyr Lys 
            20                  25                  30          


Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe Thr Trp Val Gln 
        35                  40                  45              


Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser Asp Gln Asn Arg 
    50                  55                  60                  


Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro Gly Glu Asn Arg 
65                  70                  75                  80  


Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg Lys Ile Val Cys 
                85                  90                  95      


Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys Leu Glu Ala Phe 
            100                 105                 110         


Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn Ser Ala Leu Ile 
        115                 120                 125             


Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu Met Lys His Gln 
    130                 135                 140                 


Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu Arg Trp Pro Glu 
145                 150                 155                 160 


Asp Phe Gln Asp Val Gly Trp Phe Leu His Lys Leu Ser Gln Gln Ile 
                165                 170                 175     


Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn Ile Pro Leu Gln 
            180                 185                 190         


Thr Val Ala Thr Ile Ser 
        195             


<210> 162
<211> 189
<212> PRT
<213> Homo sapiens

<400> 162
Tyr Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr Gln 
1               5                   10                  15      


Thr Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn 
            20                  25                  30          


Leu Gln Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser Ala Trp 
        35                  40                  45              


Val Lys Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln Ile 
    50                  55                  60                  


Cys Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu Asn 
65                  70                  75                  80  


Ile Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser 
                85                  90                  95      


Pro Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala 
            100                 105                 110         


His His Asn Leu Phe His Glu Gly Ser Asn Asn Leu Ile Leu Ile Leu 
        115                 120                 125             


Leu Glu Pro Ile Pro Gln Asn Ser Ile Pro Asn Lys Tyr His Lys Leu 
    130                 135                 140                 


Lys Ala Leu Met Thr Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu Lys 
145                 150                 155                 160 


Ser Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe Asn Met 
                165                 170                 175     


Lys Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser 
            180                 185                 


<210> 163
<211> 189
<212> PRT
<213> Homo sapiens

<400> 163
His Leu Tyr Phe Trp Asp Val Trp Tyr Ile Tyr His Phe Cys Lys Ala 
1               5                   10                  15      


Lys Ile Lys Gly Tyr Gln Arg Leu Ile Ser Pro Asp Cys Cys Tyr Asp 
            20                  25                  30          


Ala Phe Ile Val Tyr Asp Thr Lys Asp Pro Ala Val Thr Glu Trp Val 
        35                  40                  45              


Leu Ala Glu Leu Val Ala Lys Leu Glu Asp Pro Arg Glu Lys His Phe 
    50                  55                  60                  


Asn Leu Cys Leu Glu Glu Arg Asp Trp Leu Pro Gly Gln Pro Val Leu 
65                  70                  75                  80  


Glu Asn Leu Ser Gln Ser Ile Gln Leu Ser Lys Lys Thr Val Phe Val 
                85                  90                  95      


Met Thr Asp Lys Tyr Ala Lys Thr Glu Asn Phe Lys Ile Ala Phe Tyr 
            100                 105                 110         


Leu Ser His Gln Arg Leu Met Asp Glu Lys Val Asp Val Ile Ile Leu 
        115                 120                 125             


Ile Phe Leu Glu Lys Pro Phe Gln Lys Ser Lys Phe Leu Gln Leu Arg 
    130                 135                 140                 


Lys Arg Leu Cys Gly Ser Ser Val Leu Glu Trp Pro Thr Asn Pro Gln 
145                 150                 155                 160 


Ala His Pro Tyr Phe Trp Gln Cys Leu Lys Asn Ala Leu Ala Thr Asp 
                165                 170                 175     


Asn His Val Ala Tyr Ser Gln Val Phe Lys Glu Thr Val 
            180                 185                 


<210> 164
<211> 193
<212> PRT
<213> Homo sapiens

<400> 164
His His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val Cys Leu 
1               5                   10                  15      


Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr Phe Tyr 
            20                  25                  30          


Asp Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp 
        35                  40                  45              


Val Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp Lys Asn 
    50                  55                  60                  


Val Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile 
65                  70                  75                  80  


Ile Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr Val Phe 
                85                  90                  95      


Val Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe 
            100                 105                 110         


Tyr Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val Ile Ile 
        115                 120                 125             


Phe Ile Leu Leu Glu Pro Val Leu Gln His Ser Gln Tyr Leu Arg Leu 
    130                 135                 140                 


Arg Gln Arg Ile Cys Lys Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro 
145                 150                 155                 160 


Lys Ala Glu Gly Leu Phe Trp Gln Thr Leu Arg Asn Val Val Leu Thr 
                165                 170                 175     


Glu Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val Asp Ser Ile Lys Gln 
            180                 185                 190         


Tyr 
    


<210> 165
<211> 193
<212> PRT
<213> Homo sapiens

<400> 165
Gly Trp Asp Leu Trp Tyr Cys Phe His Leu Cys Leu Ala Trp Leu Pro 
1               5                   10                  15      


Trp Arg Gly Arg Gln Ser Gly Arg Asp Glu Asp Ala Leu Pro Tyr Asp 
            20                  25                  30          


Ala Phe Val Val Phe Asp Lys Thr Gln Ser Ala Val Ala Asp Trp Val 
        35                  40                  45              


Tyr Asn Glu Leu Arg Gly Gln Leu Glu Glu Cys Arg Gly Arg Trp Ala 
    50                  55                  60                  


Leu Arg Leu Cys Leu Glu Glu Arg Asp Trp Leu Pro Gly Lys Thr Leu 
65                  70                  75                  80  


Phe Glu Asn Leu Trp Ala Ser Val Tyr Gly Ser Arg Lys Thr Leu Phe 
                85                  90                  95      


Val Leu Ala His Thr Asp Arg Val Ser Gly Leu Leu Arg Ala Ser Phe 
            100                 105                 110         


Leu Leu Ala Gln Gln Arg Leu Leu Glu Asp Arg Lys Asp Val Val Val 
        115                 120                 125             


Leu Val Ile Leu Ser Pro Asp Gly Arg Arg Ser Arg Tyr Val Arg Leu 
    130                 135                 140                 


Arg Gln Arg Leu Cys Arg Gln Ser Val Leu Leu Trp Pro His Gln Pro 
145                 150                 155                 160 


Ser Gly Gln Arg Ser Phe Trp Ala Gln Leu Gly Met Ala Leu Thr Arg 
                165                 170                 175     


Asp Asn His His Phe Tyr Asn Arg Asn Phe Cys Gln Gly Pro Thr Ala 
            180                 185                 190         


Glu 
    


<210> 166
<211> 48
<212> PRT
<213> Homo sapiens

<400> 166
Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210> 167
<211> 383
<212> PRT
<213> Homo sapiens

<400> 167
Cys Tyr Arg Lys Lys Gly Lys Ala Leu Thr Ala Asn Leu Trp His Trp 
1               5                   10                  15      


Ile Asn Glu Ala Cys Gly Arg Leu Ser Gly Asp Lys Glu Ser Ser Gly 
            20                  25                  30          


Asp Ser Cys Val Ser Thr His Thr Ala Asn Phe Gly Gln Gln Gly Ala 
        35                  40                  45              


Cys Glu Gly Val Leu Leu Leu Thr Leu Glu Glu Lys Thr Phe Pro Glu 
    50                  55                  60                  


Asp Met Cys Tyr Pro Asp Gln Gly Gly Val Cys Gln Gly Thr Cys Val 
65                  70                  75                  80  


Gly Gly Gly Pro Tyr Ala Gln Gly Glu Asp Ala Arg Met Leu Ser Leu 
                85                  90                  95      


Val Ser Lys Thr Glu Ile Glu Glu Asp Ser Phe Arg Gln Met Pro Thr 
            100                 105                 110         


Glu Asp Glu Tyr Met Asp Arg Pro Ser Gln Pro Thr Asp Gln Leu Leu 
        115                 120                 125             


Phe Leu Thr Glu Pro Gly Ser Lys Ser Thr Pro Pro Phe Ser Glu Pro 
    130                 135                 140                 


Leu Glu Val Gly Glu Asn Asp Ser Leu Ser Gln Cys Phe Thr Gly Thr 
145                 150                 155                 160 


Gln Ser Thr Val Gly Ser Glu Ser Cys Asn Cys Thr Glu Pro Leu Cys 
                165                 170                 175     


Arg Thr Asp Trp Thr Pro Met Ser Ser Glu Asn Tyr Leu Gln Lys Glu 
            180                 185                 190         


Val Asp Ser Gly His Cys Pro His Trp Ala Ala Ser Pro Ser Pro Asn 
        195                 200                 205             


Trp Ala Asp Val Cys Thr Gly Cys Arg Asn Pro Pro Gly Glu Asp Cys 
    210                 215                 220                 


Glu Pro Leu Val Gly Ser Pro Lys Arg Gly Pro Leu Pro Gln Cys Ala 
225                 230                 235                 240 


Tyr Gly Met Gly Leu Pro Pro Glu Glu Glu Ala Ser Arg Thr Glu Ala 
                245                 250                 255     


Arg Asp Gln Pro Glu Asp Gly Ala Asp Gly Arg Leu Pro Ser Ser Ala 
            260                 265                 270         


Arg Ala Gly Ala Gly Ser Gly Ser Ser Pro Gly Gly Gln Ser Pro Ala 
        275                 280                 285             


Ser Gly Asn Val Thr Gly Asn Ser Asn Ser Thr Phe Ile Ser Ser Gly 
    290                 295                 300                 


Gln Val Met Asn Phe Lys Gly Asp Ile Ile Val Val Tyr Val Ser Gln 
305                 310                 315                 320 


Thr Ser Gln Glu Gly Ala Ala Ala Ala Ala Glu Pro Met Gly Arg Pro 
                325                 330                 335     


Val Gln Glu Glu Thr Leu Ala Arg Arg Asp Ser Phe Ala Gly Asn Gly 
            340                 345                 350         


Pro Arg Phe Pro Asp Pro Cys Gly Gly Pro Glu Gly Leu Arg Glu Pro 
        355                 360                 365             


Glu Lys Ala Ser Arg Pro Val Gln Glu Gln Gly Gly Ala Lys Ala 
    370                 375                 380             


<210> 168
<211> 28
<212> PRT
<213> Homo sapiens

<400> 168
Arg Arg Cys Arg Arg Arg Glu Lys Phe Thr Thr Pro Ile Glu Glu Thr 
1               5                   10                  15      


Gly Gly Glu Gly Cys Pro Ala Val Ala Leu Ile Gln 
            20                  25              


<210> 169
<211> 107
<212> PRT
<213> Homo sapiens

<400> 169
Lys Lys Arg Gly Asp Pro Cys Ser Cys Gln Pro Arg Ser Arg Pro Arg 
1               5                   10                  15      


Gln Ser Pro Ala Lys Ser Ser Gln Asp His Ala Met Glu Ala Gly Ser 
            20                  25                  30          


Pro Val Ser Thr Ser Pro Glu Pro Val Glu Thr Cys Ser Phe Cys Phe 
        35                  40                  45              


Pro Glu Cys Arg Ala Pro Thr Gln Glu Ser Ala Val Thr Pro Gly Thr 
    50                  55                  60                  


Pro Asp Pro Thr Cys Ala Gly Arg Trp Gly Cys His Thr Arg Thr Thr 
65                  70                  75                  80  


Val Leu Gln Pro Cys Pro His Ile Pro Asp Ser Gly Leu Gly Ile Val 
                85                  90                  95      


Cys Val Pro Ala Gln Glu Gly Gly Pro Gly Ala 
            100                 105         


<210> 170
<211> 85
<212> PRT
<213> Homo sapiens

<400> 170
Ser Trp Arg Arg Arg Gln Arg Arg Leu Arg Gly Ala Ser Ser Ala Glu 
1               5                   10                  15      


Ala Pro Asp Gly Asp Lys Asp Ala Pro Glu Pro Leu Asp Lys Val Ile 
            20                  25                  30          


Ile Leu Ser Pro Gly Ile Ser Asp Ala Thr Ala Pro Ala Trp Pro Pro 
        35                  40                  45              


Pro Gly Glu Asp Pro Gly Thr Thr Pro Pro Gly His Ser Val Pro Val 
    50                  55                  60                  


Pro Ala Thr Glu Leu Gly Ser Thr Glu Leu Val Thr Thr Lys Thr Ala 
65                  70                  75                  80  


Gly Pro Glu Gln Gln 
                85  


<210> 171
<211> 60
<212> PRT
<213> Homo sapiens

<400> 171
Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val 
1               5                   10                  15      


Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile 
            20                  25                  30          


Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu 
        35                  40                  45              


Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
    50                  55                  60  


<210> 172
<211> 155
<212> PRT
<213> Homo sapiens

<400> 172
Lys Arg Trp Asn Ser Cys Lys Gln Asn Lys Gln Gly Ala Asn Ser Arg 
1               5                   10                  15      


Pro Val Asn Gln Thr Pro Pro Pro Glu Gly Glu Lys Leu His Ser Asp 
            20                  25                  30          


Ser Gly Ile Ser Val Asp Ser Gln Ser Leu His Asp Gln Gln Pro His 
        35                  40                  45              


Thr Gln Thr Ala Ser Gly Gln Ala Leu Lys Gly Asp Gly Gly Leu Tyr 
    50                  55                  60                  


Ser Ser Leu Pro Pro Ala Lys Arg Glu Glu Val Glu Lys Leu Leu Asn 
65                  70                  75                  80  


Gly Ser Ala Gly Asp Thr Trp Arg His Leu Ala Gly Glu Leu Gly Tyr 
                85                  90                  95      


Gln Pro Glu His Ile Asp Ser Phe Thr His Glu Ala Cys Pro Val Arg 
            100                 105                 110         


Ala Leu Leu Ala Ser Trp Ala Thr Gln Asp Ser Ala Thr Leu Asp Ala 
        115                 120                 125             


Leu Leu Ala Ala Leu Arg Arg Ile Gln Arg Ala Asp Leu Val Glu Ser 
    130                 135                 140                 


Leu Cys Ser Glu Ser Thr Ala Thr Ser Pro Val 
145                 150                 155 


<210> 173
<211> 107
<212> PRT
<213> Homo sapiens

<400> 173
Arg Lys Ile Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly 
1               5                   10                  15      


Ser Gly Leu Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr 
            20                  25                  30          


Gly Asp Glu Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu 
        35                  40                  45              


Cys Thr Cys Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp 
    50                  55                  60                  


His Cys Phe Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val 
65                  70                  75                  80  


Thr Thr Lys Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser 
                85                  90                  95      


Ala Thr Glu Ile Glu Lys Ser Ile Ser Ala Arg 
            100                 105         


<210> 174
<211> 58
<212> PRT
<213> Homo sapiens

<400> 174
Gln Leu Gly Leu His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro 
1               5                   10                  15      


Arg Glu Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
            20                  25                  30          


Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu 
        35                  40                  45              


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
    50                  55              


<210> 175
<211> 232
<212> PRT
<213> Homo sapiens

<400> 175
Tyr Cys Lys Arg Gln Phe Met Glu Lys Lys Pro Ser Trp Ser Leu Arg 
1               5                   10                  15      


Ser Gln Asp Ile Gln Tyr Asn Gly Ser Glu Leu Ser Cys Phe Asp Arg 
            20                  25                  30          


Pro Gln Leu His Glu Tyr Ala His Arg Ala Cys Cys Gln Cys Arg Arg 
        35                  40                  45              


Asp Ser Val Gln Thr Cys Gly Pro Val Arg Leu Leu Pro Ser Met Cys 
    50                  55                  60                  


Cys Glu Glu Ala Cys Ser Pro Asn Pro Ala Thr Leu Gly Cys Gly Val 
65                  70                  75                  80  


His Ser Ala Ala Ser Leu Gln Ala Arg Asn Ala Gly Pro Ala Gly Glu 
                85                  90                  95      


Met Val Pro Thr Phe Phe Gly Ser Leu Thr Gln Ser Ile Cys Gly Glu 
            100                 105                 110         


Phe Ser Asp Ala Trp Pro Leu Met Gln Asn Pro Met Gly Gly Asp Asn 
        115                 120                 125             


Ile Ser Phe Cys Asp Ser Tyr Pro Glu Leu Thr Gly Glu Asp Ile His 
    130                 135                 140                 


Ser Leu Asn Pro Glu Leu Glu Ser Ser Thr Ser Leu Asp Ser Asn Ser 
145                 150                 155                 160 


Ser Gln Asp Leu Val Gly Gly Ala Val Pro Val Gln Ser His Ser Glu 
                165                 170                 175     


Asn Phe Thr Ala Ala Thr Asp Leu Ser Arg Tyr Asn Asn Thr Leu Val 
            180                 185                 190         


Glu Ser Ala Ser Thr Gln Asp Ala Leu Thr Met Arg Ser Gln Leu Asp 
        195                 200                 205             


Gln Glu Ser Gly Ala Val Ile His Pro Ala Thr Gln Thr Ser Leu Gln 
    210                 215                 220                 


Val Arg Gln Arg Leu Gly Ser Leu 
225                 230         


<210> 176
<211> 247
<212> PRT
<213> Homo sapiens

<400> 176
Asn Leu Leu Lys Arg Lys Gly Tyr His Cys Thr Ala His Lys Glu Val 
1               5                   10                  15      


Gly Pro Gly Pro Gly Gly Gly Gly Ser Gly Ile Asn Pro Ala Tyr Arg 
            20                  25                  30          


Thr Glu Asp Ala Asn Glu Asp Thr Ile Gly Val Leu Val Arg Leu Ile 
        35                  40                  45              


Thr Glu Lys Lys Glu Asn Ala Ala Ala Leu Glu Glu Leu Leu Lys Glu 
    50                  55                  60                  


Tyr His Ser Lys Gln Leu Val Gln Thr Ser His Arg Pro Val Ser Lys 
65                  70                  75                  80  


Leu Pro Pro Ala Pro Pro Asn Val Pro His Ile Cys Pro His Arg His 
                85                  90                  95      


His Leu His Thr Val Gln Gly Leu Ala Ser Leu Ser Gly Pro Cys Cys 
            100                 105                 110         


Ser Arg Cys Ser Gln Lys Lys Trp Pro Glu Val Leu Leu Ser Pro Glu 
        115                 120                 125             


Ala Val Ala Ala Thr Thr Pro Val Pro Ser Leu Leu Pro Asn Pro Thr 
    130                 135                 140                 


Arg Val Pro Lys Ala Gly Ala Lys Ala Gly Arg Gln Gly Glu Ile Thr 
145                 150                 155                 160 


Ile Leu Ser Val Gly Arg Phe Arg Val Ala Arg Ile Pro Glu Gln Arg 
                165                 170                 175     


Thr Ser Ser Met Val Ser Glu Val Lys Thr Ile Thr Glu Ala Gly Pro 
            180                 185                 190         


Ser Trp Gly Asp Leu Pro Asp Ser Pro Gln Pro Gly Leu Pro Pro Glu 
        195                 200                 205             


Gln Gln Ala Leu Leu Gly Ser Gly Gly Ser Arg Thr Lys Trp Leu Lys 
    210                 215                 220                 


Pro Pro Ala Glu Asn Lys Ala Glu Glu Asn Arg Tyr Val Val Arg Leu 
225                 230                 235                 240 


Ser Glu Ser Asn Leu Val Ile 
                245         


<210> 177
<211> 223
<212> PRT
<213> Homo sapiens

<400> 177
Met Tyr Arg Tyr Gln Arg Trp Lys Ser Lys Leu Tyr Ser Ile Val Cys 
1               5                   10                  15      


Gly Lys Ser Thr Pro Glu Lys Glu Gly Glu Leu Glu Gly Thr Thr Thr 
            20                  25                  30          


Lys Pro Leu Ala Pro Asn Pro Ser Phe Ser Pro Thr Pro Gly Phe Thr 
        35                  40                  45              


Pro Thr Leu Gly Phe Ser Pro Val Pro Ser Ser Thr Phe Thr Ser Ser 
    50                  55                  60                  


Ser Thr Tyr Thr Pro Gly Asp Cys Pro Asn Phe Ala Ala Pro Arg Arg 
65                  70                  75                  80  


Glu Val Ala Pro Pro Tyr Gln Gly Ala Asp Pro Ile Leu Ala Thr Ala 
                85                  90                  95      


Leu Ala Ser Asp Pro Ile Pro Asn Pro Leu Gln Lys Trp Glu Asp Ser 
            100                 105                 110         


Ala His Lys Pro Gln Ser Leu Asp Thr Asp Asp Pro Ala Thr Leu Tyr 
        115                 120                 125             


Ala Val Val Glu Asn Val Pro Pro Leu Arg Trp Lys Glu Phe Val Arg 
    130                 135                 140                 


Arg Leu Gly Leu Ser Asp His Glu Ile Asp Arg Leu Glu Leu Gln Asn 
145                 150                 155                 160 


Gly Arg Cys Leu Arg Glu Ala Gln Tyr Ser Met Leu Ala Thr Trp Arg 
                165                 170                 175     


Arg Arg Thr Pro Arg Arg Glu Ala Thr Leu Glu Leu Leu Gly Arg Val 
            180                 185                 190         


Leu Arg Asp Met Asp Leu Leu Gly Cys Leu Glu Asp Ile Glu Glu Ala 
        195                 200                 205             


Leu Cys Gly Pro Ala Ala Leu Pro Pro Ala Pro Ser Leu Leu Arg 
    210                 215                 220             


<210> 178
<211> 174
<212> PRT
<213> Homo sapiens

<400> 178
Lys Lys Lys Pro Leu Cys Leu Gln Arg Glu Ala Lys Val Pro His Leu 
1               5                   10                  15      


Pro Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His Leu 
            20                  25                  30          


Leu Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala 
        35                  40                  45              


Ser Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro 
    50                  55                  60                  


Gly Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser 
65                  70                  75                  80  


Ser Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys 
                85                  90                  95      


Ile Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser 
            100                 105                 110         


Gln Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu Ser 
        115                 120                 125             


Pro Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg 
    130                 135                 140                 


Ser Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys 
145                 150                 155                 160 


Pro Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
                165                 170                 


<210> 179
<211> 197
<212> PRT
<213> Homo sapiens

<400> 179
Thr Tyr Thr Tyr Arg His Cys Trp Pro His Lys Pro Leu Val Thr Ala 
1               5                   10                  15      


Asp Glu Ala Gly Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His Leu 
            20                  25                  30          


Ser Pro Leu Asp Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser Ser 
        35                  40                  45              


Glu Lys Ile Cys Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro Gly 
    50                  55                  60                  


Tyr Pro Glu Thr Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser Trp 
65                  70                  75                  80  


Asp Gln Leu Pro Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu 
                85                  90                  95      


Ser Pro Glu Ser Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro Gly 
            100                 105                 110         


Pro Gln Leu Tyr Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp Lys 
        115                 120                 125             


Glu Phe Val Arg Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala Val 
    130                 135                 140                 


Glu Val Glu Ile Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys 
145                 150                 155                 160 


Arg Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala Ala 
                165                 170                 175     


Leu Glu Arg Met Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser Arg 
            180                 185                 190         


Leu Gln Arg Gly Pro 
        195         


<210> 180
<211> 138
<212> PRT
<213> Homo sapiens

<400> 180
Leu Tyr Cys Lys Gln Phe Phe Asn Arg His Cys Gln Arg Gly Gly Leu 
1               5                   10                  15      


Leu Gln Phe Glu Ala Asp Lys Thr Ala Lys Glu Glu Ser Leu Phe Pro 
            20                  25                  30          


Val Pro Pro Ser Lys Glu Thr Ser Ala Glu Ser Gln Val Ser Glu Asn 
        35                  40                  45              


Ile Phe Gln Thr Gln Pro Leu Asn Pro Ile Leu Glu Asp Asp Cys Ser 
    50                  55                  60                  


Ser Thr Ser Gly Phe Pro Thr Gln Glu Ser Phe Thr Met Ala Ser Cys 
65                  70                  75                  80  


Thr Ser Glu Ser His Ser His Trp Val His Ser Pro Ile Glu Cys Thr 
                85                  90                  95      


Glu Leu Asp Leu Gln Lys Phe Ser Ser Ser Ala Ser Tyr Thr Gly Ala 
            100                 105                 110         


Glu Thr Leu Gly Gly Asn Thr Val Glu Ser Thr Gly Asp Arg Leu Glu 
        115                 120                 125             


Leu Asn Val Pro Phe Glu Val Pro Ser Pro 
    130                 135             


<210> 181
<211> 187
<212> PRT
<213> Homo sapiens

<400> 181
Lys Ser His Pro Ser Leu Cys Arg Lys Leu Gly Ser Leu Leu Lys Arg 
1               5                   10                  15      


Arg Pro Gln Gly Glu Gly Pro Asn Pro Val Ala Gly Ser Trp Glu Pro 
            20                  25                  30          


Pro Lys Ala His Pro Tyr Phe Pro Asp Leu Val Gln Pro Leu Leu Pro 
        35                  40                  45              


Ile Ser Gly Asp Val Ser Pro Val Ser Thr Gly Leu Pro Ala Ala Pro 
    50                  55                  60                  


Val Leu Glu Ala Gly Val Pro Gln Gln Gln Ser Pro Leu Asp Leu Thr 
65                  70                  75                  80  


Arg Glu Pro Gln Leu Glu Pro Gly Glu Gln Ser Gln Val Ala His Gly 
                85                  90                  95      


Thr Asn Gly Ile His Val Thr Gly Gly Ser Met Thr Ile Thr Gly Asn 
            100                 105                 110         


Ile Tyr Ile Tyr Asn Gly Pro Val Leu Gly Gly Pro Pro Gly Pro Gly 
        115                 120                 125             


Asp Leu Pro Ala Thr Pro Glu Pro Pro Tyr Pro Ile Pro Glu Glu Gly 
    130                 135                 140                 


Asp Pro Gly Pro Pro Gly Leu Ser Thr Pro His Gln Glu Asp Gly Lys 
145                 150                 155                 160 


Ala Trp His Leu Ala Glu Thr Glu His Cys Gly Ala Thr Pro Ser Asn 
                165                 170                 175     


Arg Gly Pro Arg Asn Gln Phe Ile Thr His Asp 
            180                 185         


<210> 182
<211> 42
<212> PRT
<213> Homo sapiens

<400> 182
Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210> 183
<211> 62
<212> PRT
<213> Homo sapiens

<400> 183
Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
1               5                   10                  15      


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
            20                  25                  30          


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
        35                  40                  45              


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    50                  55                  60          


<210> 184
<211> 189
<212> PRT
<213> Homo sapiens

<400> 184
Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu 
1               5                   10                  15      


Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser 
            20                  25                  30          


Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr 
        35                  40                  45              


Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu 
    50                  55                  60                  


Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln 
65                  70                  75                  80  


Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu 
                85                  90                  95      


Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr 
            100                 105                 110         


Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu 
        115                 120                 125             


Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu 
    130                 135                 140                 


Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu 
145                 150                 155                 160 


Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu 
                165                 170                 175     


Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185                 


<210> 185
<211> 42
<212> PRT
<213> Homo sapiens

<400> 185
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210> 186
<211> 240
<212> PRT
<213> Homo sapiens

<400> 186
Tyr Ile Leu Lys Thr Lys Pro Ser Ala Pro Ala Cys Cys Thr Ser His 
1               5                   10                  15      


Pro Gly Lys Ser Val Glu Ala Gln Val Ser Lys Asp Glu Glu Lys Lys 
            20                  25                  30          


Glu Ala Pro Asp Asn Val Val Met Phe Ser Glu Lys Asp Glu Phe Glu 
        35                  40                  45              


Lys Leu Thr Ala Thr Pro Ala Lys Pro Thr Lys Ser Glu Asn Asp Ala 
    50                  55                  60                  


Ser Ser Glu Asn Glu Gln Leu Leu Ser Arg Ser Val Asp Ser Asp Glu 
65                  70                  75                  80  


Glu Pro Ala Pro Asp Lys Gln Gly Ser Pro Glu Leu Cys Leu Leu Ser 
                85                  90                  95      


Leu Val His Leu Ala Arg Glu Lys Ser Ala Thr Ser Asn Lys Ser Ala 
            100                 105                 110         


Gly Ile Gln Ser Arg Arg Lys Lys Ile Leu Asp Val Tyr Ala Asn Val 
        115                 120                 125             


Cys Gly Val Val Glu Gly Leu Ser Pro Thr Glu Leu Pro Phe Asp Cys 
    130                 135                 140                 


Leu Glu Lys Thr Ser Arg Met Leu Ser Ser Thr Tyr Asn Ser Glu Lys 
145                 150                 155                 160 


Ala Val Val Lys Thr Trp Arg His Leu Ala Glu Ser Phe Gly Leu Lys 
                165                 170                 175     


Arg Asp Glu Ile Gly Gly Met Thr Asp Gly Met Gln Leu Phe Asp Arg 
            180                 185                 190         


Ile Ser Thr Ala Gly Tyr Ser Ile Pro Glu Leu Leu Thr Lys Leu Val 
        195                 200                 205             


Gln Ile Glu Arg Leu Asp Ala Val Glu Ser Leu Cys Ala Asp Ile Leu 
    210                 215                 220                 


Glu Trp Ala Gly Val Val Pro Pro Ala Ser Gln Pro His Ala Ala Ser 
225                 230                 235                 240 


<210> 187
<211> 235
<212> PRT
<213> Homo sapiens

<400> 187
His Cys His Arg Leu Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser 
1               5                   10                  15      


Leu Tyr Pro Arg Gly Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro 
            20                  25                  30          


Trp Pro Pro Ala Tyr Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln 
        35                  40                  45              


Pro Asp Leu Leu Pro Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser 
    50                  55                  60                  


His Arg Thr Pro Ser Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val 
65                  70                  75                  80  


Ala Ser Tyr Glu Asn Glu Gly Ala Ser Gly Ile Arg Gly Ala Gln Ala 
                85                  90                  95      


Gly Trp Gly Val Trp Gly Pro Ser Trp Thr Arg Leu Thr Pro Val Ser 
            100                 105                 110         


Leu Pro Pro Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp 
        115                 120                 125             


Tyr His Asn Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala 
    130                 135                 140                 


Thr Ser Thr Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile 
145                 150                 155                 160 


Arg Asp Ser Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val 
                165                 170                 175     


Pro Glu Ser Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu 
            180                 185                 190         


Tyr Val Asn Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu 
        195                 200                 205             


Pro Ala Ala Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly 
    210                 215                 220                 


Ala Pro Asp Tyr Glu Asn Leu Gln Glu Leu Asn 
225                 230                 235 


<210> 188
<211> 217
<212> PRT
<213> Homo sapiens

<400> 188
Arg Cys Ser Arg Pro Gly Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln 
1               5                   10                  15      


Arg Ser Leu Arg Glu Asp Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr 
            20                  25                  30          


Ser Leu Val Gly Gln Ala Trp Pro Gly Pro Leu Ala Asp Met Ala Pro 
        35                  40                  45              


Thr Arg Lys Asp Lys Leu Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro 
    50                  55                  60                  


Ala Ser Ser Arg Tyr Gln Asn Phe Ser Lys Gly Ser Arg His Gly Ser 
65                  70                  75                  80  


Glu Glu Ala Tyr Ile Asp Pro Ile Ala Met Glu Tyr Tyr Asn Trp Gly 
                85                  90                  95      


Arg Phe Ser Lys Pro Pro Glu Asp Asp Asp Ala Asn Ser Tyr Glu Asn 
            100                 105                 110         


Val Leu Ile Cys Lys Gln Lys Thr Thr Glu Thr Gly Ala Gln Gln Glu 
        115                 120                 125             


Gly Ile Gly Gly Leu Cys Arg Gly Asp Leu Ser Leu Ser Leu Ala Leu 
    130                 135                 140                 


Lys Thr Gly Pro Thr Ser Gly Leu Cys Pro Ser Ala Ser Pro Glu Glu 
145                 150                 155                 160 


Asp Glu Glu Ser Glu Asp Tyr Gln Asn Ser Ala Ser Ile His Gln Trp 
                165                 170                 175     


Arg Glu Ser Arg Lys Val Met Gly Gln Leu Gln Arg Glu Ala Ser Pro 
            180                 185                 190         


Gly Pro Val Gly Ser Pro Asp Glu Glu Asp Gly Glu Pro Asp Tyr Val 
        195                 200                 205             


Asn Gly Glu Val Ala Ala Thr Glu Ala 
    210                 215         


<210> 189
<211> 340
<212> PRT
<213> Homo sapiens

<400> 189
Trp Asn Trp Asn Lys Arg Lys Lys Arg Gln Val Pro Tyr Leu Arg Val 
1               5                   10                  15      


Thr Val Met Pro Leu Leu Thr Leu Pro Gln Thr Arg Gln Arg Ala Lys 
            20                  25                  30          


Asn Ile Tyr Asp Ile Leu Pro Trp Arg Gln Glu Asp Leu Gly Arg His 
        35                  40                  45              


Glu Ser Arg Ser Met Arg Ile Phe Ser Thr Glu Ser Leu Leu Ser Arg 
    50                  55                  60                  


Asn Ser Glu Ser Pro Glu His Val Pro Ser Gln Ala Gly Asn Ala Phe 
65                  70                  75                  80  


Gln Glu His Thr Ala His Ile His Ala Thr Glu Tyr Ala Val Gly Ile 
                85                  90                  95      


Tyr Asp Asn Ala Met Val Pro Gln Met Cys Gly Asn Leu Thr Pro Ser 
            100                 105                 110         


Ala His Cys Ile Asn Val Arg Ala Ser Arg Asp Cys Ala Ser Ile Ser 
        115                 120                 125             


Ser Glu Asp Ser His Asp Tyr Val Asn Val Pro Thr Ala Glu Glu Ile 
    130                 135                 140                 


Ala Glu Thr Leu Ala Ser Thr Lys Ser Pro Ser Arg Asn Leu Phe Val 
145                 150                 155                 160 


Leu Pro Ser Thr Gln Lys Leu Glu Phe Thr Glu Glu Arg Asp Glu Gly 
                165                 170                 175     


Cys Gly Asp Ala Gly Asp Cys Thr Ser Leu Tyr Ser Pro Gly Ala Glu 
            180                 185                 190         


Asp Ser Asp Ser Leu Ser Asn Gly Glu Gly Ser Ser Gln Ile Ser Asn 
        195                 200                 205             


Asp Tyr Val Asn Met Thr Gly Leu Asp Leu Ser Ala Ile Gln Glu Arg 
    210                 215                 220                 


Gln Leu Trp Val Ala Phe Gln Cys Cys Arg Asp Tyr Glu Asn Val Pro 
225                 230                 235                 240 


Ala Ala Asp Pro Ser Gly Ser Gln Gln Gln Ala Glu Lys Asp Val Pro 
                245                 250                 255     


Ser Ser Asn Ile Gly His Val Glu Asp Lys Thr Asp Asp Pro Gly Thr 
            260                 265                 270         


His Val Gln Cys Val Lys Arg Thr Phe Leu Ala Ser Gly Asp Tyr Ala 
        275                 280                 285             


Asp Phe Gln Pro Phe Thr Gln Ser Glu Asp Ser Gln Met Lys His Arg 
    290                 295                 300                 


Glu Glu Met Ser Asn Glu Asp Ser Ser Asp Tyr Glu Asn Val Leu Thr 
305                 310                 315                 320 


Ala Lys Leu Gly Gly Arg Asp Ser Glu Gln Gly Pro Gly Thr Gln Leu 
                325                 330                 335     


Leu Pro Asp Glu 
            340 


<210> 190
<211> 395
<212> PRT
<213> Homo sapiens

<400> 190
Ser Ser Cys Asp Arg Glu Lys Lys Pro Arg Gln His Ser Gly Asp His 
1               5                   10                  15      


Glu Asn Leu Met Asn Val Pro Ser Asp Lys Glu Met Phe Ser Arg Ser 
            20                  25                  30          


Val Thr Ser Leu Ala Thr Asp Ala Pro Ala Ser Ser Glu Gln Asn Gly 
        35                  40                  45              


Ala Leu Thr Asn Gly Asp Ile Leu Ser Glu Asp Ser Thr Leu Thr Cys 
    50                  55                  60                  


Met Gln His Tyr Glu Glu Val Gln Thr Ser Ala Ser Asp Leu Leu Asp 
65                  70                  75                  80  


Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His Gln Ser Arg Glu Leu 
                85                  90                  95      


Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr Met Leu Thr Ala Arg 
            100                 105                 110         


Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu Gly Pro Tyr Glu Val 
        115                 120                 125             


Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val Glu Asp Cys Leu Tyr 
    130                 135                 140                 


Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala Ala Ala His Leu Glu 
145                 150                 155                 160 


Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser Lys Glu Leu 
                165                 170                 175     


Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu Tyr Ala Ser 
            180                 185                 190         


Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val Asn Val Glu Ser Ile 
        195                 200                 205             


Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro Pro Val Pro 
    210                 215                 220                 


Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys Glu Gly Gly 
225                 230                 235                 240 


Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr Asn Lys Arg 
                245                 250                 255     


Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro Thr Leu Thr 
            260                 265                 270         


Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val Asn Lys Pro Gly Gln 
        275                 280                 285             


Leu Val Asn Lys Ser Gly Gln Ser Leu Thr Val Pro Glu Ser Thr Tyr 
    290                 295                 300                 


Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser Pro Ser Ser Cys Asn Asp 
305                 310                 315                 320 


Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys Thr Pro Asn Ser Thr Leu 
                325                 330                 335     


Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro Glu Pro Asp Tyr Glu Ala 
            340                 345                 350         


Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys Ala Thr Leu Gly Thr Asn 
        355                 360                 365             


Gly His His Gly Leu Val Pro Lys Glu Asn Asp Tyr Glu Ser Ile Ser 
    370                 375                 380                 


Asp Leu Gln Gln Gly Arg Asp Ile Thr Arg Leu 
385                 390                 395 


<210> 191
<211> 235
<212> PRT
<213> Homo sapiens

<400> 191
His Cys His Arg Leu Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser 
1               5                   10                  15      


Leu Tyr Pro Arg Gly Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro 
            20                  25                  30          


Trp Pro Pro Ala Tyr Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln 
        35                  40                  45              


Pro Asp Leu Leu Pro Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser 
    50                  55                  60                  


His Arg Thr Pro Ser Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val 
65                  70                  75                  80  


Ala Ser Tyr Glu Asn Glu Gly Ala Ser Gly Ile Arg Gly Ala Gln Ala 
                85                  90                  95      


Gly Trp Gly Val Trp Gly Pro Ser Trp Thr Arg Leu Thr Pro Val Ser 
            100                 105                 110         


Leu Pro Pro Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp 
        115                 120                 125             


Tyr His Asn Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala 
    130                 135                 140                 


Thr Ser Thr Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile 
145                 150                 155                 160 


Arg Asp Ser Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val 
                165                 170                 175     


Pro Glu Ser Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu 
            180                 185                 190         


Tyr Val Asn Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu 
        195                 200                 205             


Pro Ala Ala Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly 
    210                 215                 220                 


Ala Pro Asp Tyr Glu Asn Leu Gln Glu Leu Asn 
225                 230                 235 


<210> 192
<211> 21
<212> PRT
<213> Homo sapiens

<400> 192
Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg 
1               5                   10                  15      


Cys Cys Arg Arg Gly 
            20      


<210> 193
<211> 37
<212> PRT
<213> Homo sapiens

<400> 193
Met Ser Asp Ser Lys Glu Pro Arg Leu Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Glu Gln Leu Arg Gly Leu Gly Phe Arg Gln Thr Arg Gly Tyr Lys 
            20                  25                  30          


Ser Leu Ala Gly Cys 
        35          


<210> 194
<211> 33
<212> PRT
<213> Homo sapiens

<400> 194
Met Gln Asp Glu Asp Gly Tyr Ile Thr Leu Asn Ile Lys Thr Arg Lys 
1               5                   10                  15      


Pro Ala Leu Ile Ser Val Gly Ser Ala Ser Ser Ser Trp Trp Arg Val 
            20                  25                  30          


Met 
    


<210> 195
<211> 44
<212> PRT
<213> Homo sapiens

<400> 195
Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Thr 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Thr Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Ser Cys Ala Ala Ser Pro Pro Trp Arg 
        35                  40                  


<210> 196
<211> 35
<212> PRT
<213> Homo sapiens

<400> 196
Met His Glu Glu Glu Ile Tyr Thr Ser Leu Gln Trp Asp Ser Pro Ala 
1               5                   10                  15      


Pro Asp Thr Tyr Gln Lys Cys Leu Ser Ser Asn Lys Cys Ser Gly Ala 
            20                  25                  30          


Cys Cys Leu 
        35  


<210> 197
<211> 38
<212> PRT
<213> Homo sapiens

<400> 197
Met Gln Asp Glu Glu Arg Tyr Met Thr Leu Asn Val Gln Ser Lys Lys 
1               5                   10                  15      


Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr Ser Val 
            20                  25                  30          


Thr Leu His Trp Tyr Lys 
        35              


<210> 198
<211> 30
<212> PRT
<213> Homo sapiens

<400> 198
Met Glu Asn Glu Asp Gly Tyr Met Thr Leu Ser Phe Lys Asn Arg Cys 
1               5                   10                  15      


Lys Ser Lys Gln Lys Ser Lys Asp Phe Ser Leu Tyr Pro Gln 
            20                  25                  30  


<210> 199
<211> 70
<212> PRT
<213> Homo sapiens

<400> 199
Met Ser Lys Gln Arg Gly Thr Phe Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Ser 
            20                  25                  30          


Gly Thr Glu Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Pro 
        35                  40                  45              


Ser Leu Asn His Gln Gly Ile Asp Lys Ile Tyr Asp Cys Gln Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys 
65                  70  


<210> 200
<211> 51
<212> PRT
<213> Homo sapiens

<400> 200
Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser 
    50      


<210> 201
<211> 70
<212> PRT
<213> Homo sapiens

<400> 201
Met Ser Lys Gln Arg Gly Thr Phe Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Trp Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Ser 
            20                  25                  30          


Gly Thr Glu Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Ala 
        35                  40                  45              


Ser Leu Asn His Gln Gly Ile Asp Lys Ile Tyr Asp Cys Gln Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys 
65                  70  


<210> 202
<211> 19
<212> PRT
<213> Homo sapiens

<400> 202
Met Asn Ser Ser Lys Ser Ser Glu Thr Gln Cys Thr Glu Arg Gly Cys 
1               5                   10                  15      


Phe Ser Ser 
            


<210> 203
<211> 20
<212> PRT
<213> Homo sapiens

<400> 203
Met Met Gln Glu Gln Gln Pro Gln Ser Thr Glu Lys Arg Gly Trp Leu 
1               5                   10                  15      


Ser Leu Arg Leu 
            20  


<210> 204
<211> 39
<212> PRT
<213> Homo sapiens

<400> 204
Met Thr Arg Thr Tyr Glu Asn Phe Gln Tyr Leu Glu Asn Lys Val Lys 
1               5                   10                  15      


Val Gln Gly Phe Lys Asn Gly Pro Leu Pro Leu Gln Ser Leu Leu Gln 
            20                  25                  30          


Arg Leu Cys Ser Gly Pro Cys 
        35                  


<210> 205
<211> 17
<212> PRT
<213> Homo sapiens

<400> 205
Met Gly Leu Glu Lys Pro Gln Ser Lys Leu Glu Gly Gly Met His Pro 
1               5                   10                  15      


Gln 
    


<210> 206
<211> 21
<212> PRT
<213> Homo sapiens

<400> 206
Met Val Pro Glu Glu Glu Pro Gln Asp Arg Glu Lys Gly Leu Trp Trp 
1               5                   10                  15      


Phe Gln Leu Lys Val 
            20      


<210> 207
<211> 172
<212> PRT
<213> Homo sapiens

<400> 207
Met His Asn Leu Tyr Ser Ile Thr Gly Tyr Pro Asp Pro Pro Gly Thr 
1               5                   10                  15      


Met Glu Glu Glu Glu Glu Asp Asp Asp Tyr Glu Asn Ser Thr Pro Pro 
            20                  25                  30          


Tyr Lys Asp Leu Pro Pro Lys Pro Gly Thr Met Glu Glu Glu Glu Glu 
        35                  40                  45              


Asp Asp Asp Tyr Glu Asn Ser Thr Pro Pro Tyr Lys Asp Leu Pro Pro 
    50                  55                  60                  


Lys Pro Gly Thr Met Glu Glu Glu Glu Glu Asp Asp Asp Tyr Glu Asn 
65                  70                  75                  80  


Ser Thr Pro Pro Tyr Lys Asp Leu Pro Pro Lys Pro Gly Ser Ser Ala 
                85                  90                  95      


Pro Pro Arg Pro Pro Arg Ala Ala Lys Glu Thr Glu Lys Pro Pro Leu 
            100                 105                 110         


Pro Cys Lys Pro Arg Asn Met Thr Gly Leu Asp Leu Ala Ala Val Thr 
        115                 120                 125             


Cys Pro Pro Pro Gln Leu Ala Val Asn Leu Glu Pro Ser Pro Leu Gln 
    130                 135                 140                 


Pro Ser Leu Ala Ala Thr Pro Val Pro Trp Leu Asn Gln Arg Ser Gly 
145                 150                 155                 160 


Gly Pro Gly Cys Cys Gln Lys Arg Trp Met Val Tyr 
                165                 170         


<210> 208
<211> 17
<212> PRT
<213> Homo sapiens

<400> 208
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys 
    


<210> 209
<211> 37
<212> PRT
<213> Homo sapiens

<400> 209
Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg 
        35          


<210> 210
<211> 37
<212> PRT
<213> Homo sapiens

<400> 210
Met Asp Pro Gly Leu Gln Gln Ala Leu Asn Gly Met Ala Pro Pro Gly 
1               5                   10                  15      


Asp Thr Ala Met His Val Pro Ala Gly Ser Val Ala Ser His Leu Gly 
            20                  25                  30          


Thr Thr Ser Arg Ser 
        35          


<210> 211
<211> 35
<212> PRT
<213> Homo sapiens

<400> 211
Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu 
        35  


<210> 212
<211> 23
<212> PRT
<213> Homo sapiens

<400> 212
Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys 
            20              


<210> 213
<211> 22
<212> PRT
<213> Homo sapiens

<400> 213
Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys 
            20          


<210> 214
<211> 80
<212> PRT
<213> Homo sapiens

<400> 214
Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


<210> 215
<211> 28
<212> PRT
<213> Homo sapiens

<400> 215
Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro 
            20                  25              


<210> 216
<211> 17
<212> PRT
<213> Homo sapiens

<400> 216
Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val 
    


<210> 217
<211> 47
<212> PRT
<213> Homo sapiens

<400> 217
Met Arg Arg Ala Ser Arg Asp Tyr Thr Lys Tyr Leu Arg Gly Ser Glu 
1               5                   10                  15      


Glu Met Gly Gly Gly Pro Gly Ala Pro His Glu Gly Pro Leu His Ala 
            20                  25                  30          


Pro Pro Pro Pro Ala Pro His Gln Pro Pro Ala Ala Ser Arg Ser 
        35                  40                  45          


<210> 218
<211> 21
<212> PRT
<213> Homo sapiens

<400> 218
Met Ala Ala Arg Arg Ser Gln Arg Arg Arg Gly Arg Arg Gly Glu Pro 
1               5                   10                  15      


Gly Thr Ala Leu Leu 
            20      


<210> 219
<211> 28
<212> PRT
<213> Homo sapiens

<400> 219
Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      


Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser 
            20                  25              


<210> 220
<211> 46
<212> PRT
<213> Homo sapiens

<400> 220
Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys 
        35                  40                  45      


<210> 221
<211> 28
<212> PRT
<213> Homo sapiens

<400> 221
Met Cys Leu Ser His Leu Glu Asn Met Pro Leu Ser His Ser Arg Thr 
1               5                   10                  15      


Gln Gly Ala Gln Arg Ser Ser Trp Lys Leu Trp Leu 
            20                  25              


<210> 222
<211> 36
<212> PRT
<213> Homo sapiens

<400> 222
Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser Leu Cys Ala Arg 
1               5                   10                  15      


Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met 
            20                  25                  30          


Pro Gly Arg Gly 
        35      


<210> 223
<211> 21
<212> PRT
<213> Homo sapiens

<400> 223
Leu Leu Pro Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys 
1               5                   10                  15      


Leu Phe Cys Cys Leu 
            20      


<210> 224
<211> 20
<212> PRT
<213> Homo sapiens

<400> 224
Leu Gln Glu Lys Val Trp Val Met Leu Val Thr Ser Leu Val Ala Leu 
1               5                   10                  15      


Gln Gly Met Ser 
            20  


<210> 225
<211> 21
<212> PRT
<213> Homo sapiens

<400> 225
Tyr Ile Pro Tyr Ile Ile Leu Thr Ile Ile Ile Leu Thr Ile Val Gly 
1               5                   10                  15      


Phe Ile Trp Leu Leu 
            20      


<210> 226
<211> 23
<212> PRT
<213> Homo sapiens

<400> 226
Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Cys Leu Ile Phe Phe Ile Val 
            20              


<210> 227
<211> 24
<212> PRT
<213> Homo sapiens

<400> 227
Ala Ile Ala Gly Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile 
1               5                   10                  15      


Ala Val Ala Leu Ala Cys Phe Leu 
            20                  


<210> 228
<211> 21
<212> PRT
<213> Homo sapiens

<400> 228
Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe Tyr 
1               5                   10                  15      


Ser Phe Leu Leu Thr 
            20      


<210> 229
<211> 17
<212> PRT
<213> Homo sapiens

<400> 229
Leu Gly Trp Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp 
1               5                   10                  15      


Val 
    


<210> 230
<211> 21
<212> PRT
<213> Homo sapiens

<400> 230
Leu Val Pro Trp Leu Pro Ala Ser Leu Leu Gly Leu Met Val Ile Ala 
1               5                   10                  15      


Ala Ala Leu Leu Val 
            20      


<210> 231
<211> 21
<212> PRT
<213> Homo sapiens

<400> 231
Val Ile Ile Phe Phe Ala Phe Val Leu Leu Leu Ser Gly Ala Leu Ala 
1               5                   10                  15      


Tyr Cys Leu Ala Leu 
            20      


<210> 232
<211> 22
<212> PRT
<213> Homo sapiens

<400> 232
Trp Met Val Ala Val Ile Leu Met Ala Ser Val Phe Met Val Cys Leu 
1               5                   10                  15      


Ala Leu Leu Gly Cys Phe 
            20          


<210> 233
<211> 22
<212> PRT
<213> Homo sapiens

<400> 233
Val Ala Ala Val Leu Ala Ser Leu Leu Val Leu Leu Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Leu Leu Tyr Val 
            20          


<210> 234
<211> 21
<212> PRT
<213> Homo sapiens

<400> 234
Thr Phe Leu Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys 
1               5                   10                  15      


Ile Ala Ile Val Leu 
            20      


<210> 235
<211> 22
<212> PRT
<213> Homo sapiens

<400> 235
Ala Ile Val Val Pro Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu 
1               5                   10                  15      


Gly Val Leu Phe Cys Phe 
            20          


<210> 236
<211> 19
<212> PRT
<213> Homo sapiens

<400> 236
Ile Leu Ile Gly Thr Ser Val Val Ile Ile Leu Phe Ile Leu Leu Phe 
1               5                   10                  15      


Phe Leu Leu 
            


<210> 237
<211> 19
<212> PRT
<213> Homo sapiens

<400> 237
Ile Leu Ile Gly Thr Ser Val Val Ile Ile Leu Phe Ile Leu Leu Phe 
1               5                   10                  15      


Phe Leu Leu 
            


<210> 238
<211> 20
<212> PRT
<213> Homo sapiens

<400> 238
Val Leu Ile Gly Thr Ser Val Val Ile Ile Leu Phe Ile Leu Leu Leu 
1               5                   10                  15      


Phe Phe Leu Leu 
            20  


<210> 239
<211> 21
<212> PRT
<213> Homo sapiens

<400> 239
Leu His Ile Leu Ile Gly Thr Ser Val Ala Ile Ile Leu Phe Ile Ile 
1               5                   10                  15      


Leu Phe Phe Phe Leu 
            20      


<210> 240
<211> 21
<212> PRT
<213> Homo sapiens

<400> 240
Leu His Ile Leu Ile Gly Thr Ser Val Ala Ile Ile Leu Phe Ile Ile 
1               5                   10                  15      


Leu Phe Phe Phe Leu 
            20      


<210> 241
<211> 20
<212> PRT
<213> Homo sapiens

<400> 241
Ile Leu Ile Gly Thr Ser Val Val Ile Ile Leu Phe Ile Leu Leu Leu 
1               5                   10                  15      


Phe Phe Leu Leu 
            20  


<210> 242
<211> 20
<212> PRT
<213> Homo sapiens

<400> 242
Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe Ile Leu Leu Leu 
1               5                   10                  15      


Phe Phe Leu Leu 
            20  


<210> 243
<211> 21
<212> PRT
<213> Homo sapiens

<400> 243
His Val Leu Ile Gly Thr Ser Val Val Ile Ile Pro Phe Ala Ile Leu 
1               5                   10                  15      


Leu Phe Phe Leu Leu 
            20      


<210> 244
<211> 21
<212> PRT
<213> Homo sapiens

<400> 244
Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu Val Thr 
1               5                   10                  15      


Gly Ala Phe Gly Phe 
            20      


<210> 245
<211> 21
<212> PRT
<213> Homo sapiens

<400> 245
Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Phe Leu Ile 
            20      


<210> 246
<211> 21
<212> PRT
<213> Homo sapiens

<400> 246
Val Ile Gly Ile Leu Val Ala Val Val Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Phe Leu Ile 
            20      


<210> 247
<211> 21
<212> PRT
<213> Homo sapiens

<400> 247
Val Leu Ile Gly Val Ser Val Ala Phe Val Leu Leu Leu Phe Leu Leu 
1               5                   10                  15      


Leu Phe Leu Leu Leu 
            20      


<210> 248
<211> 21
<212> PRT
<213> Homo sapiens

<400> 248
Val Leu Ile Gly Val Leu Val Val Ser Ile Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Phe Leu Leu Leu 
            20      


<210> 249
<211> 21
<212> PRT
<213> Homo sapiens

<400> 249
Val Val Thr Gly Val Ser Val Ala Phe Val Leu Leu Leu Phe Leu Leu 
1               5                   10                  15      


Leu Phe Leu Leu Leu 
            20      


<210> 250
<211> 21
<212> PRT
<213> Homo sapiens

<400> 250
Ala Gly Thr Val Leu Leu Leu Arg Ala Gly Phe Tyr Ala Val Ser Phe 
1               5                   10                  15      


Leu Ser Val Ala Val 
            20      


<210> 251
<211> 21
<212> PRT
<213> Homo sapiens

<400> 251
Val Gly Val Val Gly Gly Leu Leu Gly Ser Leu Val Leu Leu Val Trp 
1               5                   10                  15      


Val Leu Ala Val Ile 
            20      


<210> 252
<211> 21
<212> PRT
<213> Homo sapiens

<400> 252
Gly Ala Phe Leu Gly Ile Gly Ile Thr Ala Leu Leu Phe Leu Cys Leu 
1               5                   10                  15      


Ala Leu Ile Ile Met 
            20      


<210> 253
<211> 23
<212> PRT
<213> Homo sapiens

<400> 253
Gly Ala Val Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Ser Phe 
1               5                   10                  15      


Cys Val Ile Phe Ile Val Val 
            20              


<210> 254
<211> 21
<212> PRT
<213> Homo sapiens

<400> 254
Val Val Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Ser Phe Cys 
1               5                   10                  15      


Val Ile Phe Val Val 
            20      


<210> 255
<211> 21
<212> PRT
<213> Homo sapiens

<400> 255
Ser Trp Pro Val Ile Val Ala Ala Leu Leu Phe Cys Cys Met Ile Leu 
1               5                   10                  15      


Phe Gly Leu Gly Val 
            20      


<210> 256
<211> 21
<212> PRT
<213> Homo sapiens

<400> 256
Ala Ala Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met 
1               5                   10                  15      


Leu Met Val Tyr Ile 
            20      


<210> 257
<211> 21
<212> PRT
<213> Homo sapiens

<400> 257
Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val 
1               5                   10                  15      


Ile Ile Ile Phe Tyr 
            20      


<210> 258
<211> 21
<212> PRT
<213> Homo sapiens

<400> 258
Leu Leu Gly Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val 
1               5                   10                  15      


Ile Val Val Val Ala 
            20      


<210> 259
<211> 21
<212> PRT
<213> Homo sapiens

<400> 259
Ile Tyr Ile Gly Ala Gly Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Phe Gly Ala Leu Ile 
            20      


<210> 260
<211> 21
<212> PRT
<213> Homo sapiens

<400> 260
Leu Ile Ser Gly Thr Leu Gly Ile Ile Cys Leu Ser Leu Met Ser Thr 
1               5                   10                  15      


Leu Gly Ile Leu Leu 
            20      


<210> 261
<211> 21
<212> PRT
<213> Homo sapiens

<400> 261
Ala Gly Ile Ile Leu Leu Val Leu Val Val Thr Gly Leu Ser Val Ser 
1               5                   10                  15      


Val Thr Ser Leu Ile 
            20      


<210> 262
<211> 21
<212> PRT
<213> Homo sapiens

<400> 262
Val Ala Ile Ala Leu Gly Leu Leu Thr Ala Val Leu Leu Ser Val Leu 
1               5                   10                  15      


Leu Tyr Gln Trp Ile 
            20      


<210> 263
<211> 23
<212> PRT
<213> Homo sapiens

<400> 263
Leu Ile Val Gly Ile Leu Gly Ile Ile Cys Leu Ile Leu Met Ala Ser 
1               5                   10                  15      


Val Val Thr Ile Val Val Ile 
            20              


<210> 264
<211> 21
<212> PRT
<213> Homo sapiens

<400> 264
Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
1               5                   10                  15      


Val Gly Ala Val Phe 
            20      


<210> 265
<211> 21
<212> PRT
<213> Homo sapiens

<400> 265
Ala Ile Ser Val Gly Ile Ser Leu Leu Leu Leu Leu Val Val Cys Gly 
1               5                   10                  15      


Ile Gly Cys Val Trp 
            20      


<210> 266
<211> 21
<212> PRT
<213> Homo sapiens

<400> 266
Gly Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu 
1               5                   10                  15      


Ile Ala Leu Ala Val 
            20      


<210> 267
<211> 21
<212> PRT
<213> Homo sapiens

<400> 267
Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr Gly Ile Val Leu 
1               5                   10                  15      


Thr Leu Leu Tyr Cys 
            20      


<210> 268
<211> 21
<212> PRT
<213> Homo sapiens

<400> 268
Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu Val Asn Thr Val 
1               5                   10                  15      


Leu Trp Val Thr Ile 
            20      


<210> 269
<211> 23
<212> PRT
<213> Homo sapiens

<400> 269
Ile Ile Val Ala Val Val Ile Ala Thr Ala Val Ala Ala Ile Val Ala 
1               5                   10                  15      


Ala Val Val Ala Leu Ile Tyr 
            20              


<210> 270
<211> 23
<212> PRT
<213> Homo sapiens

<400> 270
Ile Ile Val Ala Val Val Thr Gly Ile Ala Val Ala Ala Ile Val Ala 
1               5                   10                  15      


Ala Val Val Ala Leu Ile Tyr 
            20              


<210> 271
<211> 21
<212> PRT
<213> Homo sapiens

<400> 271
Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
1               5                   10                  15      


Leu Tyr Phe Ser Val 
            20      


<210> 272
<211> 19
<212> PRT
<213> Homo sapiens

<400> 272
Leu Ile Arg Met Ala Val Ala Gly Leu Val Leu Val Ala Leu Leu Ala 
1               5                   10                  15      


Ile Leu Val 
            


<210> 273
<211> 23
<212> PRT
<213> Homo sapiens

<400> 273
Tyr Ala Leu Ile Pro Ile Pro Leu Ala Val Ile Thr Thr Cys Ile Val 
1               5                   10                  15      


Leu Tyr Met Asn Gly Ile Leu 
            20              


<210> 274
<211> 21
<212> PRT
<213> Homo sapiens

<400> 274
Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe Leu Gly Thr Leu 
1               5                   10                  15      


Ala Cys Phe Cys Val 
            20      


<210> 275
<211> 21
<212> PRT
<213> Homo sapiens

<400> 275
Trp Ala Val Tyr Ala Gly Leu Leu Gly Gly Val Ile Met Ile Leu Ile 
1               5                   10                  15      


Met Val Val Ile Leu 
            20      


<210> 276
<211> 21
<212> PRT
<213> Homo sapiens

<400> 276
Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu Ser 
1               5                   10                  15      


Ser Val Phe Leu Phe 
            20      


<210> 277
<211> 21
<212> PRT
<213> Homo sapiens

<400> 277
Ile Leu Phe Met Val Ser Gly Ile Cys Ile Val Phe Gly Phe Ile Ile 
1               5                   10                  15      


Leu Leu Leu Leu Val 
            20      


<210> 278
<211> 21
<212> PRT
<213> Homo sapiens

<400> 278
Val Leu Leu Cys Leu Leu Leu Val Pro Leu Leu Leu Ser Leu Phe Val 
1               5                   10                  15      


Leu Gly Leu Phe Leu 
            20      


<210> 279
<211> 26
<212> PRT
<213> Homo sapiens

<400> 279
Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val 
1               5                   10                  15      


Phe Val Ala Leu Leu Val Phe Tyr Ile Thr 
            20                  25      


<210> 280
<211> 22
<212> PRT
<213> Homo sapiens

<400> 280
Leu Trp Ile Gly Leu Phe Leu Met Val Cys Leu Leu Cys Val Gly Ile 
1               5                   10                  15      


Phe Ser Trp Cys Ile Trp 
            20          


<210> 281
<211> 26
<212> PRT
<213> Homo sapiens

<400> 281
Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly 
1               5                   10                  15      


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
            20                  25      


<210> 282
<211> 21
<212> PRT
<213> Homo sapiens

<400> 282
Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val Leu Ala Val Gly 
1               5                   10                  15      


Val Tyr Phe Ile Ala 
            20      


<210> 283
<211> 21
<212> PRT
<213> Homo sapiens

<400> 283
Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210> 284
<211> 21
<212> PRT
<213> Homo sapiens

<400> 284
Ile Val Thr Gly Val Leu Val Gly Val Ala Leu Val Ala Ala Leu Val 
1               5                   10                  15      


Cys Phe Leu Leu Leu 
            20      


<210> 285
<211> 25
<212> PRT
<213> Homo sapiens

<400> 285
Ala Leu Ile Val Gly Thr Leu Ser Gly Thr Ile Phe Phe Ile Leu Leu 
1               5                   10                  15      


Ile Ile Phe Leu Ser Trp Ile Ile Leu 
            20                  25  


<210> 286
<211> 23
<212> PRT
<213> Homo sapiens

<400> 286
Val Trp Val Ile Ala Val Ile Val Ile Ala Ile Val Val Gly Val Ala 
1               5                   10                  15      


Val Ile Cys Val Val Pro Tyr 
            20              


<210> 287
<211> 21
<212> PRT
<213> Homo sapiens

<400> 287
Gly Val Val Ile Ile Val Ile Leu Leu Ile Leu Thr Gly Ala Gly Leu 
1               5                   10                  15      


Ala Ala Tyr Phe Phe 
            20      


<210> 288
<211> 17
<212> PRT
<213> Homo sapiens

<400> 288
Val Leu Ala Leu Ile Val Ile Phe Leu Thr Ile Ala Val Leu Leu Ala 
1               5                   10                  15      


Leu 
    


<210> 289
<211> 21
<212> PRT
<213> Homo sapiens

<400> 289
Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
1               5                   10                  15      


Val Tyr Phe Trp Leu 
            20      


<210> 290
<211> 21
<212> PRT
<213> Homo sapiens

<400> 290
Phe Ile Leu Ile Ser Ser Leu Ala Ile Leu Leu Met Val Ser Leu Leu 
1               5                   10                  15      


Leu Leu Ser Leu Trp 
            20      


<210> 291
<211> 23
<212> PRT
<213> Homo sapiens

<400> 291
Leu Ile Leu Thr Leu Ser Leu Ile Leu Val Val Ile Leu Val Leu Leu 
1               5                   10                  15      


Thr Val Leu Ala Leu Leu Ser 
            20              


<210> 292
<211> 23
<212> PRT
<213> Homo sapiens

<400> 292
Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr Cys Leu Cys 
1               5                   10                  15      


Gly Thr Ala Trp Leu Cys Cys 
            20              


<210> 293
<211> 26
<212> PRT
<213> Homo sapiens

<400> 293
Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu 
1               5                   10                  15      


Val Cys Gly Ile Val Leu Gly Phe Leu Phe 
            20                  25      


<210> 294
<211> 21
<212> PRT
<213> Homo sapiens

<400> 294
Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe Ala Leu Pro Phe 
1               5                   10                  15      


Val Ile Tyr Ala Ala 
            20      


<210> 295
<211> 21
<212> PRT
<213> Homo sapiens

<400> 295
Ile Gly Gly Ile Ile Thr Val Phe Leu Ile Ala Leu Val Leu Thr Ser 
1               5                   10                  15      


Thr Ile Val Thr Leu 
            20      


<210> 296
<211> 21
<212> PRT
<213> Homo sapiens

<400> 296
Phe Leu Val Leu Pro Ser Leu Leu Ile Leu Leu Leu Val Ile Ala Ala 
1               5                   10                  15      


Gly Gly Val Ile Trp 
            20      


<210> 297
<211> 21
<212> PRT
<213> Homo sapiens

<400> 297
Val Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu 
1               5                   10                  15      


Glu Met Val Leu Phe 
            20      


<210> 298
<211> 20
<212> PRT
<213> Homo sapiens

<400> 298
His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
1               5                   10                  15      


Val Phe Ile Tyr 
            20  


<210> 299
<211> 21
<212> PRT
<213> Homo sapiens

<400> 299
Ile Tyr Cys Ile Ile Ala Val Cys Ser Val Phe Leu Met Leu Ile Asn 
1               5                   10                  15      


Val Leu Val Ile Ile 
            20      


<210> 300
<211> 21
<212> PRT
<213> Homo sapiens

<400> 300
Ala Tyr Leu Ile Gly Gly Leu Ile Ala Leu Val Ala Val Ala Val Ser 
1               5                   10                  15      


Val Val Tyr Ile Tyr 
            20      


<210> 301
<211> 21
<212> PRT
<213> Homo sapiens

<400> 301
Ser Leu Gly Ile Leu Ser Phe Leu Gly Leu Val Ala Gly Ala Leu Ala 
1               5                   10                  15      


Leu Gly Leu Trp Leu 
            20      


<210> 302
<211> 25
<212> PRT
<213> Homo sapiens

<400> 302
Trp Leu Ile Phe Phe Ala Ser Leu Gly Ser Phe Leu Ser Ile Leu Leu 
1               5                   10                  15      


Val Gly Val Leu Gly Tyr Leu Gly Leu 
            20                  25  


<210> 303
<211> 21
<212> PRT
<213> Homo sapiens

<400> 303
Trp Met Ala Phe Val Ala Pro Ser Ile Cys Ile Ala Ile Ile Met Val 
1               5                   10                  15      


Gly Ile Phe Ser Thr 
            20      


<210> 304
<211> 21
<212> PRT
<213> Homo sapiens

<400> 304
Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser Val 
1               5                   10                  15      


Ile Leu Leu Ile Val 
            20      


<210> 305
<211> 21
<212> PRT
<213> Homo sapiens

<400> 305
Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val Leu Val Ala Gly 
1               5                   10                  15      


Ile Tyr Leu Met Trp 
            20      


<210> 306
<211> 21
<212> PRT
<213> Homo sapiens

<400> 306
Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala Ala Leu Ser 
1               5                   10                  15      


Leu Ile Leu Leu Leu 
            20      


<210> 307
<211> 21
<212> PRT
<213> Homo sapiens

<400> 307
Leu Gly Leu Leu Ile Leu Ala Leu Leu Ala Leu Leu Thr Leu Leu Gly 
1               5                   10                  15      


Val Val Leu Ala Leu 
            20      


<210> 308
<211> 21
<212> PRT
<213> Homo sapiens

<400> 308
Gly Met Ile Ile Ala Val Leu Ile Leu Val Ala Val Val Cys Leu Val 
1               5                   10                  15      


Thr Val Cys Val Ile 
            20      


<210> 309
<211> 21
<212> PRT
<213> Homo sapiens

<400> 309
Gly Val Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile Gly Thr Leu Val 
1               5                   10                  15      


Ala Val Leu Ala Ala 
            20      


<210> 310
<211> 25
<212> PRT
<213> Homo sapiens

<400> 310
Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
1               5                   10                  15      


Phe Ile Ile Leu Val Tyr Leu Leu Ile 
            20                  25  


<210> 311
<211> 21
<212> PRT
<213> Homo sapiens

<400> 311
Gly Trp Asn Pro His Leu Leu Leu Leu Leu Leu Leu Val Ile Val Phe 
1               5                   10                  15      


Ile Pro Ala Phe Trp 
            20      


<210> 312
<211> 21
<212> PRT
<213> Homo sapiens

<400> 312
Tyr Ser Phe Ser Gly Ala Phe Leu Phe Ser Met Gly Phe Leu Val Ala 
1               5                   10                  15      


Val Leu Cys Tyr Leu 
            20      


<210> 313
<211> 21
<212> PRT
<213> Homo sapiens

<400> 313
Leu Leu Leu Gly Met Ile Val Phe Ala Val Met Leu Ser Ile Leu Ser 
1               5                   10                  15      


Leu Ile Gly Ile Phe 
            20      


<210> 314
<211> 21
<212> PRT
<213> Homo sapiens

<400> 314
Val Leu Pro Gly Ile Leu Phe Leu Trp Gly Leu Phe Leu Leu Gly Cys 
1               5                   10                  15      


Gly Leu Ser Leu Ala 
            20      


<210> 315
<211> 20
<212> PRT
<213> Homo sapiens

<400> 315
Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu Val Cys Val 
1               5                   10                  15      


Phe Val Ile Cys 
            20  


<210> 316
<211> 22
<212> PRT
<213> Homo sapiens

<400> 316
Ala Ile Val Val Pro Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu 
1               5                   10                  15      


Gly Val Leu Phe Cys Phe 
            20          


<210> 317
<211> 25
<212> PRT
<213> Homo sapiens

<400> 317
Pro Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu 
1               5                   10                  15      


Leu Val Ile Leu Ala Cys Val Leu Trp 
            20                  25  


<210> 318
<211> 25
<212> PRT
<213> Homo sapiens

<400> 318
Val Gly Leu Ile Ile Ala Ile Leu Ile Pro Val Ala Val Ala Val Ile 
1               5                   10                  15      


Val Gly Val Val Thr Ser Ile Leu Cys 
            20                  25  


<210> 319
<211> 21
<212> PRT
<213> Homo sapiens

<400> 319
Val Val Val Ala Cys Met Ser Ile Met Ala Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Tyr 
            20      


<210> 320
<211> 21
<212> PRT
<213> Homo sapiens

<400> 320
Leu Ile His Ile Leu Leu Pro Met Val Phe Cys Val Leu Leu Ile Met 
1               5                   10                  15      


Val Met Cys Tyr Leu 
            20      


<210> 321
<211> 23
<212> PRT
<213> Homo sapiens

<400> 321
Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala 
1               5                   10                  15      


Leu Gly Ile Gly Leu Phe Met 
            20              


<210> 322
<211> 24
<212> PRT
<213> Homo sapiens

<400> 322
Phe Pro Trp Leu Leu Ile Ile Ile Phe Gly Ile Phe Gly Leu Thr Val 
1               5                   10                  15      


Met Leu Phe Val Phe Leu Phe Ser 
            20                  


<210> 323
<211> 23
<212> PRT
<213> Homo sapiens

<400> 323
Ile Ile Ile Gly Pro Leu Ile Phe Val Phe Leu Phe Ser Val Val Ile 
1               5                   10                  15      


Gly Ser Ile Tyr Leu Phe Leu 
            20              


<210> 324
<211> 23
<212> PRT
<213> Homo sapiens

<400> 324
Ala Gly Leu Tyr Val Ile Val Pro Val Ile Ile Ser Ser Ser Ile Leu 
1               5                   10                  15      


Leu Leu Gly Thr Leu Leu Ile 
            20              


<210> 325
<211> 24
<212> PRT
<213> Homo sapiens

<400> 325
Thr Thr Val Trp Ile Ser Val Ala Val Leu Ser Ala Val Ile Cys Leu 
1               5                   10                  15      


Ile Ile Val Trp Ala Val Ala Leu 
            20                  


<210> 326
<211> 22
<212> PRT
<213> Homo sapiens

<400> 326
Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val 
1               5                   10                  15      


Leu Gly Leu Leu Leu Leu 
            20          


<210> 327
<211> 23
<212> PRT
<213> Homo sapiens

<400> 327
Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala 
1               5                   10                  15      


Leu Gly Ile Gly Leu Phe Met 
            20              


<210> 328
<211> 23
<212> PRT
<213> Homo sapiens

<400> 328
Ser Ile Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly 
1               5                   10                  15      


Val Val Phe Gly Ile Leu Ile 
            20              


<210> 329
<211> 23
<212> PRT
<213> Homo sapiens

<400> 329
Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gly Phe Phe Leu Trp Leu 
            20              


<210> 330
<211> 21
<212> PRT
<213> Homo sapiens

<400> 330
Ile Ile Ile Tyr Cys Thr Gly Ala Phe Leu Ile Ser Cys Met Val Gly 
1               5                   10                  15      


Ser Val Ile Val Tyr 
            20      


<210> 331
<211> 21
<212> PRT
<213> Homo sapiens

<400> 331
Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile Ala Cys Met Val Val 
1               5                   10                  15      


Thr Val Ile Leu Cys 
            20      


<210> 332
<211> 21
<212> PRT
<213> Homo sapiens

<400> 332
Ile Leu Ser Tyr Gly Val Gly Phe Phe Leu Phe Ile Leu Val Val Ala 
1               5                   10                  15      


Ala Val Thr Leu Cys 
            20      


<210> 333
<211> 21
<212> PRT
<213> Homo sapiens

<400> 333
Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu Leu 
1               5                   10                  15      


Leu Ala Gly Leu Tyr 
            20      


<210> 334
<211> 21
<212> PRT
<213> Homo sapiens

<400> 334
Ile Ile Ile Leu Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu 
1               5                   10                  15      


Leu Leu Val Ile Ile 
            20      


<210> 335
<211> 21
<212> PRT
<213> Homo sapiens

<400> 335
Ile Val Ile Leu Val Gly Thr Gly Val Ile Ala Val Phe Phe Trp Val 
1               5                   10                  15      


Leu Leu Leu Leu Ile 
            20      


<210> 336
<211> 21
<212> PRT
<213> Homo sapiens

<400> 336
Ile Val Ala Val Ile Phe Gly Leu Leu Leu Gly Ala Ala Leu Leu Leu 
1               5                   10                  15      


Gly Ile Leu Val Phe 
            20      


<210> 337
<211> 23
<212> PRT
<213> Homo sapiens

<400> 337
Leu Ile Ala Gly Ser Ala Ala Ala Gly Val Val Phe Val Val Ser Leu 
1               5                   10                  15      


Val Ala Ile Ser Ile Val Cys 
            20              


<210> 338
<211> 21
<212> PRT
<213> Homo sapiens

<400> 338
Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
1               5                   10                  15      


Leu Val Val Ile Trp 
            20      


<210> 339
<211> 21
<212> PRT
<213> Homo sapiens

<400> 339
Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr Ile Ile Ser 
1               5                   10                  15      


Leu Ile Ile Leu Ile 
            20      


<210> 340
<211> 22
<212> PRT
<213> Homo sapiens

<400> 340
Ile Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro 
1               5                   10                  15      


Gly Thr Leu Leu Leu Phe 
            20          


<210> 341
<211> 21
<212> PRT
<213> Homo sapiens

<400> 341
Gly Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val 
1               5                   10                  15      


Pro Ile Phe Leu Leu 
            20      


<210> 342
<211> 20
<212> PRT
<213> Homo sapiens

<400> 342
Leu Gln Glu Lys Val Trp Val Met Leu Val Thr Ser Leu Val Ala Leu 
1               5                   10                  15      


Gln Gly Met Ser 
            20  


<210> 343
<211> 21
<212> PRT
<213> Homo sapiens

<400> 343
Gly Gly Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile 
1               5                   10                  15      


Ile Val Ile Phe Leu 
            20      


<210> 344
<211> 22
<212> PRT
<213> Homo sapiens

<400> 344
Ile Val Leu Leu Leu Ala Leu Val Ile Phe Tyr Leu Thr Leu Ile Ile 
1               5                   10                  15      


Phe Thr Cys Lys Phe Ala 
            20          


<210> 345
<211> 21
<212> PRT
<213> Homo sapiens

<400> 345
Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
1               5                   10                  15      


Gly Cys Ile Leu Ile 
            20      


<210> 346
<211> 23
<212> PRT
<213> Homo sapiens

<400> 346
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 
1               5                   10                  15      


Gly Leu Ser Thr Tyr Leu Tyr 
            20              


<210> 347
<211> 25
<212> PRT
<213> Homo sapiens

<400> 347
Met Val Ile Ile Val Thr Val Val Ser Val Leu Leu Ser Leu Phe Val 
1               5                   10                  15      


Thr Ser Val Leu Leu Cys Phe Ile Phe 
            20                  25  


<210> 348
<211> 25
<212> PRT
<213> Homo sapiens

<400> 348
Phe Val Pro Val Phe Val Ala Val Leu Leu Thr Leu Gly Val Val Thr 
1               5                   10                  15      


Ile Val Leu Ala Leu Met Tyr Val Phe 
            20                  25  


<210> 349
<211> 21
<212> PRT
<213> Homo sapiens

<400> 349
Ala Val Ile Arg Tyr Ser Val Ala Ile Ile Leu Phe Thr Ile Leu Pro 
1               5                   10                  15      


Phe Phe Leu Leu His 
            20      


<210> 350
<211> 19
<212> PRT
<213> Homo sapiens

<400> 350
Val Leu Ile Gly Thr Ser Val Val Lys Ile Pro Phe Thr Ile Leu Leu 
1               5                   10                  15      


Phe Phe Leu 
            


<210> 351
<211> 20
<212> PRT
<213> Homo sapiens

<400> 351
Val Leu Ile Gly Thr Ser Val Val Lys Ile Pro Phe Thr Ile Leu Leu 
1               5                   10                  15      


Phe Phe Leu Leu 
            20  


<210> 352
<211> 19
<212> PRT
<213> Homo sapiens

<400> 352
Val Leu Ile Gly Thr Ser Val Val Lys Leu Pro Phe Thr Ile Leu Leu 
1               5                   10                  15      


Phe Phe Leu 
            


<210> 353
<211> 20
<212> PRT
<213> Homo sapiens

<400> 353
Val Leu Ile Gly Thr Ser Val Val Lys Ile Pro Phe Thr Ile Leu Leu 
1               5                   10                  15      


Phe Phe Leu Leu 
            20  


<210> 354
<211> 19
<212> PRT
<213> Homo sapiens

<400> 354
Val Leu Ile Gly Thr Ser Val Val Lys Leu Pro Phe Thr Ile Leu Leu 
1               5                   10                  15      


Phe Phe Leu 
            


<210> 355
<211> 20
<212> PRT
<213> Homo sapiens

<400> 355
Ile Leu Ile Gly Thr Ser Val Val Lys Ile Pro Phe Thr Ile Leu Leu 
1               5                   10                  15      


Phe Phe Leu Leu 
            20  


<210> 356
<211> 21
<212> PRT
<213> Homo sapiens

<400> 356
Met Gly Leu Ala Phe Leu Val Leu Val Ala Leu Val Trp Phe Leu Val 
1               5                   10                  15      


Glu Asp Trp Leu Ser 
            20      


<210> 357
<211> 21
<212> PRT
<213> Homo sapiens

<400> 357
Leu Val Pro Val Phe Cys Gly Leu Leu Val Ala Lys Ser Leu Val Leu 
1               5                   10                  15      


Ser Ala Leu Leu Val 
            20      


<210> 358
<211> 21
<212> PRT
<213> Homo sapiens

<400> 358
Ala Gly Thr Val Leu Leu Leu Arg Ala Gly Phe Tyr Ala Val Ser Phe 
1               5                   10                  15      


Leu Ser Val Ala Val 
            20      


<210> 359
<211> 21
<212> PRT
<213> Homo sapiens

<400> 359
Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly Leu Gly Val 
1               5                   10                  15      


Ala Cys Val Leu Ala 
            20      


<210> 360
<211> 22
<212> PRT
<213> Homo sapiens

<400> 360
Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
1               5                   10                  15      


Gly Leu Gly Ile Phe Phe 
            20          


<210> 361
<211> 27
<212> PRT
<213> Homo sapiens

<400> 361
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210> 362
<211> 21
<212> PRT
<213> Homo sapiens

<400> 362
Phe Leu Phe Val Leu Leu Gly Val Gly Ser Met Gly Val Ala Ala Ile 
1               5                   10                  15      


Val Trp Gly Ala Trp 
            20      


<210> 363
<211> 21
<212> PRT
<213> Homo sapiens

<400> 363
Leu Trp Val Ala Val Gly Gly Ala Ala Gly Gly Ala Ala Leu Leu Ala 
1               5                   10                  15      


Ala Gly Ala Gly Leu 
            20      


<210> 364
<211> 21
<212> PRT
<213> Homo sapiens

<400> 364
Tyr Leu Tyr Val Leu Ser Gly Ile Gly Gly Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ile Phe Ile Val Leu 
            20      


<210> 365
<211> 23
<212> PRT
<213> Homo sapiens

<400> 365
Ile Ala Ala Ile Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly 
1               5                   10                  15      


Ile Leu Leu Leu Val Ile Trp 
            20              


<210> 366
<211> 21
<212> PRT
<213> Homo sapiens

<400> 366
Ile Leu Leu Leu Thr Leu Val Ser Phe Leu Ile Phe Ile Leu Phe Ile 
1               5                   10                  15      


Ile Val Gln Leu Phe 
            20      


<210> 367
<211> 19
<212> PRT
<213> Homo sapiens

<400> 367
Val Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile 
1               5                   10                  15      


Cys Gly Leu 
            


<210> 368
<211> 23
<212> PRT
<213> Homo sapiens

<400> 368
Thr Leu Ile Arg Gly Ala Leu Met Gly Ala Gly Phe Leu Leu Thr Tyr 
1               5                   10                  15      


Gly Leu Thr Trp Ile Tyr Tyr 
            20              


<210> 369
<211> 21
<212> PRT
<213> Homo sapiens

<400> 369
Val Ala Leu Leu Leu Gly Ala Leu Gly Phe Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Val Leu Ala Ala 
            20      


<210> 370
<211> 21
<212> PRT
<213> Homo sapiens

<400> 370
Val Val Leu Val Ala Val Gly Glu Val Ala Met Lys Ile Leu Leu Leu 
1               5                   10                  15      


Cys Leu Cys Leu Ile 
            20      


<210> 371
<211> 21
<212> PRT
<213> Homo sapiens

<400> 371
Ile Tyr Ala Gly Val Cys Ile Ser Val Leu Val Leu Leu Ala Leu Leu 
1               5                   10                  15      


Gly Val Ile Ile Ala 
            20      


<210> 372
<211> 21
<212> PRT
<213> Homo sapiens

<400> 372
Leu Leu Ile Val Thr Ile Val Ala Thr Met Leu Val Leu Ala Val Thr 
1               5                   10                  15      


Val Thr Ser Leu Cys 
            20      


<210> 373
<211> 21
<212> PRT
<213> Homo sapiens

<400> 373
Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu 
1               5                   10                  15      


Ala Val Ala Phe Cys 
            20      


<210> 374
<211> 21
<212> PRT
<213> Homo sapiens

<400> 374
Ala Leu Val Ser Gly Met Cys Cys Ala Leu Phe Leu Leu Ile Leu Leu 
1               5                   10                  15      


Thr Gly Val Leu Cys 
            20      


<210> 375
<211> 21
<212> PRT
<213> Homo sapiens

<400> 375
Phe Phe Met Ile Asn Thr Ser Ile Leu Leu Ile Phe Ile Phe Ile Val 
1               5                   10                  15      


Leu Leu Ile His Phe 
            20      


<210> 376
<211> 21
<212> PRT
<213> Homo sapiens

<400> 376
Thr Ile Ile Gly Val Ser Val Leu Ser Val Leu Val Val Ser Val Val 
1               5                   10                  15      


Ala Val Leu Val Tyr 
            20      


<210> 377
<211> 21
<212> PRT
<213> Homo sapiens

<400> 377
Phe Ser Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met 
1               5                   10                  15      


Thr Ile Leu Thr Val 
            20      


<210> 378
<211> 21
<212> PRT
<213> Homo sapiens

<400> 378
Leu Ile Val Thr Ile Gly Ala Thr Met Leu Val Leu Ala Val Thr Val 
1               5                   10                  15      


Thr Ser Leu Cys Ile 
            20      


<210> 379
<211> 21
<212> PRT
<213> Homo sapiens

<400> 379
Leu Ile Leu Phe Ser Leu Ser Ile Ser Val Ser Leu Phe Leu Met Val 
1               5                   10                  15      


Met Met Thr Ala Ser 
            20      


<210> 380
<211> 21
<212> PRT
<213> Homo sapiens

<400> 380
Ala Val Ile Leu Phe Phe Phe Thr Phe Phe Ile Thr Thr Met Val Met 
1               5                   10                  15      


Leu Ala Ala Leu Ala 
            20      


<210> 381
<211> 21
<212> PRT
<213> Homo sapiens

<400> 381
Phe Ala Leu Ser Leu Leu Ala Val Ala Leu Gly Leu Gly Val Pro Met 
1               5                   10                  15      


Leu His His Leu Cys 
            20      


<210> 382
<211> 21
<212> PRT
<213> Homo sapiens

<400> 382
Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly 
1               5                   10                  15      


Ala Leu Phe Leu His 
            20      


<210> 383
<211> 21
<212> PRT
<213> Homo sapiens

<400> 383
Gly Leu Ile Ile Leu Leu Leu Phe Ala Ser Val Ala Leu Val Ala Ala 
1               5                   10                  15      


Ile Ile Phe Gly Val 
            20      


<210> 384
<211> 21
<212> PRT
<213> Homo sapiens

<400> 384
Ile Leu Gly Gly Ala Leu Ser Leu Thr Phe Val Leu Gly Leu Leu Ser 
1               5                   10                  15      


Gly Phe Leu Val Trp 
            20      


<210> 385
<211> 21
<212> PRT
<213> Homo sapiens

<400> 385
Thr Leu Gly Leu Cys Leu Cys Ala Val Leu Cys Cys Phe Leu Val Ala 
1               5                   10                  15      


Val Ala Cys Phe Leu 
            20      


<210> 386
<211> 21
<212> PRT
<213> Homo sapiens

<400> 386
Phe Gly Ala Pro Ala Leu Leu Gly Leu Ala Leu Val Leu Ala Leu Val 
1               5                   10                  15      


Leu Val Gly Leu Val 
            20      


<210> 387
<211> 21
<212> PRT
<213> Homo sapiens

<400> 387
Trp Trp Phe Leu Ser Gly Ser Leu Val Ile Val Ile Val Cys Ser Thr 
1               5                   10                  15      


Val Gly Leu Ile Ile 
            20      


<210> 388
<211> 22
<212> PRT
<213> Homo sapiens

<400> 388
Leu Ile Pro Val Tyr Cys Ser Ile Leu Ala Ala Val Val Val Gly Leu 
1               5                   10                  15      


Val Ala Tyr Ile Ala Phe 
            20          


<210> 389
<211> 23
<212> PRT
<213> Homo sapiens

<400> 389
Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu Ile Ile Ser Leu Ala Val 
1               5                   10                  15      


Phe Val Leu Met Phe Leu Leu 
            20              


<210> 390
<211> 21
<212> PRT
<213> Homo sapiens

<400> 390
Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys Val Leu 
1               5                   10                  15      


Leu Leu Thr Ser Ala 
            20      


<210> 391
<211> 21
<212> PRT
<213> Homo sapiens

<400> 391
Ala Ala Val Ile Cys Ser Ala Leu Ala Thr Val Leu Leu Ala Leu Leu 
1               5                   10                  15      


Ile Leu Cys Val Ile 
            20      


<210> 392
<211> 21
<212> PRT
<213> Homo sapiens

<400> 392
Tyr Ala Val Ile Ala Ile Val Pro Val Phe Cys Leu Met Gly Leu Leu 
1               5                   10                  15      


Gly Ile Leu Val Cys 
            20      


<210> 393
<211> 21
<212> PRT
<213> Homo sapiens

<400> 393
Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Ile Gly Leu 
            20      


<210> 394
<211> 30
<212> PRT
<213> Homo sapiens

<400> 394
Phe Ala Leu Pro Val Gly Leu Ile Val Gly Val Thr Ala Leu Gly Leu 
1               5                   10                  15      


Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val 
            20                  25                  30  


<210> 395
<211> 21
<212> PRT
<213> Homo sapiens

<400> 395
Met Phe Trp Val Gln Val Leu Leu Ala Gly Leu Val Val Pro Leu Leu 
1               5                   10                  15      


Leu Gly Ala Thr Leu 
            20      


<210> 396
<211> 21
<212> PRT
<213> Homo sapiens

<400> 396
Leu Val Ala Leu Val Ser Ser Leu Leu Val Val Phe Thr Leu Ala Phe 
1               5                   10                  15      


Leu Gly Leu Phe Phe 
            20      


<210> 397
<211> 21
<212> PRT
<213> Homo sapiens

<400> 397
Leu Ala Val Leu Leu Pro Leu Ala Phe Phe Leu Leu Leu Ala Thr Val 
1               5                   10                  15      


Phe Ser Cys Ile Trp 
            20      


<210> 398
<211> 21
<212> PRT
<213> Homo sapiens

<400> 398
Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu 
            20      


<210> 399
<211> 22
<212> PRT
<213> Homo sapiens

<400> 399
Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile Leu 
1               5                   10                  15      


Leu Val Leu Val Phe Ile 
            20          


<210> 400
<211> 21
<212> PRT
<213> Homo sapiens

<400> 400
Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly Ser 
1               5                   10                  15      


Ser Ala Phe Leu Leu 
            20      


<210> 401
<211> 27
<212> PRT
<213> Homo sapiens

<400> 401
Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210> 402
<211> 21
<212> PRT
<213> Homo sapiens

<400> 402
Leu Ile Ile Ala Met Ser Thr Ile Phe Ile Met Ala Ile Ala Ile Val 
1               5                   10                  15      


Leu Ile Ile Met Phe 
            20      


<210> 403
<211> 23
<212> PRT
<213> Homo sapiens

<400> 403
Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu Pro Ile Leu Ala 
1               5                   10                  15      


Met Leu Met Ala Leu Cys Val 
            20              


<210> 404
<211> 21
<212> PRT
<213> Homo sapiens

<400> 404
Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val Leu Leu Gly Val Ala 
1               5                   10                  15      


Ala Ser Leu Cys Val 
            20      


<210> 405
<211> 21
<212> PRT
<213> Homo sapiens

<400> 405
Ile Phe Ser Gly Phe Ala Gly Leu Leu Ala Ile Leu Leu Val Val Ala 
1               5                   10                  15      


Val Phe Cys Ile Leu 
            20      


<210> 406
<211> 21
<212> PRT
<213> Homo sapiens

<400> 406
Leu Trp Gly Ser Leu Ala Ala Val Ala Ile Phe Phe Val Ile Thr Phe 
1               5                   10                  15      


Leu Ile Phe Leu Cys 
            20      


<210> 407
<211> 23
<212> PRT
<213> Homo sapiens

<400> 407
Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu Pro Ile Leu Ala 
1               5                   10                  15      


Met Leu Met Ala Leu Cys Val 
            20              


<210> 408
<211> 26
<212> PRT
<213> Homo sapiens

<400> 408
Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala Ala Leu Trp Ala Gly 
1               5                   10                  15      


Leu Leu Thr Leu Leu Leu Leu Trp His Trp 
            20                  25      


<210> 409
<211> 21
<212> PRT
<213> Homo sapiens

<400> 409
Leu Gly His Gly Pro Leu Val Leu Gln Leu Leu Ser Phe Thr Leu Leu 
1               5                   10                  15      


Ala Gly Leu Leu Val 
            20      


<210> 410
<211> 21
<212> PRT
<213> Homo sapiens

<400> 410
Ala Leu Ile Leu Leu Ile Leu Cys Val Gly Met Val Val Gly Leu Val 
1               5                   10                  15      


Ala Leu Gly Ile Trp 
            20      


<210> 411
<211> 21
<212> PRT
<213> Homo sapiens

<400> 411
Leu Ile Ala Val Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile 
1               5                   10                  15      


Ala Val Val Leu Gly 
            20      


<210> 412
<211> 21
<212> PRT
<213> Homo sapiens

<400> 412
Val Met Val Ile Ser Cys Val Phe Cys Met Gly Leu Leu Thr Ala Ser 
1               5                   10                  15      


Ile Phe Leu Gly Val 
            20      


<210> 413
<211> 21
<212> PRT
<213> Homo sapiens

<400> 413
Ile Leu Leu Gly Ile Ser Gly Thr Val Asn Gly Ile Leu Thr Leu Thr 
1               5                   10                  15      


Leu Ile Ser Leu Ile 
            20      


<210> 414
<211> 21
<212> PRT
<213> Homo sapiens

<400> 414
Tyr Tyr Cys Leu Leu Leu Ile Phe Gly Cys Ile Val Ile Leu Ile Phe 
1               5                   10                  15      


Ile Met Thr Gly Ile 
            20      


<210> 415
<211> 23
<212> PRT
<213> Homo sapiens

<400> 415
Leu Thr Ala Glu Val Leu Gly Ile Ile Cys Ile Val Leu Met Ala Thr 
1               5                   10                  15      


Val Leu Lys Thr Ile Val Leu 
            20              


<210> 416
<211> 21
<212> PRT
<213> Homo sapiens

<400> 416
Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly Ile Arg Phe 
1               5                   10                  15      


Ile Ile Met Val Ala 
            20      


<210> 417
<211> 23
<212> PRT
<213> Homo sapiens

<400> 417
Leu Thr Ala Glu Val Leu Gly Ile Ile Cys Ile Val Leu Met Ala Thr 
1               5                   10                  15      


Val Leu Lys Thr Ile Val Leu 
            20              


<210> 418
<211> 21
<212> PRT
<213> Homo sapiens

<400> 418
Gln Met Phe Leu Trp Thr Val Ala Gly Ile Pro Ile Leu Phe Leu Ser 
1               5                   10                  15      


Ala Cys Phe Ile Thr 
            20      


<210> 419
<211> 21
<212> PRT
<213> Homo sapiens

<400> 419
Trp Ser Val Ala Gly Ile Ser Ile Ala Leu Leu Ser Ala Cys Phe Ile 
1               5                   10                  15      


Val Ser Cys Val Val 
            20      


<210> 420
<211> 21
<212> PRT
<213> Homo sapiens

<400> 420
His Leu Leu Leu Ser Leu Gly Leu Gly Leu Leu Leu Leu Val Ile Ile 
1               5                   10                  15      


Cys Val Val Gly Phe 
            20      


<210> 421
<211> 21
<212> PRT
<213> Homo sapiens

<400> 421
Leu Ile Pro Ser Val Ile Ala Val Val Phe Ile Leu Leu Leu Ser Val 
1               5                   10                  15      


Cys Phe Ile Ala Ser 
            20      


<210> 422
<211> 23
<212> PRT
<213> Homo sapiens

<400> 422
Trp Ser Met Ala Val Val Ser Ile Leu Leu Leu Ser Val Cys Phe Thr 
1               5                   10                  15      


Val Ser Ser Val Val Pro His 
            20              


<210> 423
<211> 21
<212> PRT
<213> Homo sapiens

<400> 423
Leu Cys Leu Leu Val Val Thr Ser Leu Phe Leu Gly Cys Leu Gly Leu 
1               5                   10                  15      


Thr Val Thr Leu Ile 
            20      


<210> 424
<211> 21
<212> PRT
<213> Homo sapiens

<400> 424
Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile Cys 
1               5                   10                  15      


Leu Val Val Cys Ile 
            20      


<210> 425
<211> 21
<212> PRT
<213> Homo sapiens

<400> 425
Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly Ala Gly Leu Ala Val 
1               5                   10                  15      


Gln Gly Trp Phe Leu 
            20      


<210> 426
<211> 25
<212> PRT
<213> Homo sapiens

<400> 426
Tyr Phe Tyr Leu Thr Thr Ala Thr Leu Ala Leu Cys Leu Val Phe Thr 
1               5                   10                  15      


Val Ala Thr Ile Met Val Leu Val Val 
            20                  25  


<210> 427
<211> 21
<212> PRT
<213> Homo sapiens

<400> 427
Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe Cys Leu Leu 
1               5                   10                  15      


His Phe Gly Val Ile 
            20      


<210> 428
<211> 27
<212> PRT
<213> Homo sapiens

<400> 428
Leu Leu Leu Val Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu Cys 
1               5                   10                  15      


Phe Thr Tyr Ile Cys Leu His Phe Ser Ala Leu 
            20                  25          


<210> 429
<211> 24
<212> PRT
<213> Homo sapiens

<400> 429
Ile Phe Met Tyr Leu Leu Thr Val Phe Leu Ile Thr Gln Met Ile Gly 
1               5                   10                  15      


Ser Ala Leu Phe Ala Val Tyr Leu 
            20                  


<210> 430
<211> 22
<212> PRT
<213> Homo sapiens

<400> 430
Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
1               5                   10                  15      


Leu Gly Leu Gly Met Phe 
            20          


<210> 431
<211> 21
<212> PRT
<213> Homo sapiens

<400> 431
Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Cys Ala Val Phe Leu 
            20      


<210> 432
<211> 21
<212> PRT
<213> Homo sapiens

<400> 432
Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala Val 
1               5                   10                  15      


Thr Tyr Val Tyr Phe 
            20      


<210> 433
<211> 21
<212> PRT
<213> Homo sapiens

<400> 433
Met Phe Val Ala Leu Leu Gly Leu Gly Leu Gly Gln Val Val Cys Ser 
1               5                   10                  15      


Val Ala Leu Phe Phe 
            20      


<210> 434
<211> 21
<212> PRT
<213> Homo sapiens

<400> 434
Val Pro Leu Ala Leu Gly Leu Gly Leu Ala Leu Ala Cys Leu Gly Leu 
1               5                   10                  15      


Leu Leu Ala Val Val 
            20      


<210> 435
<211> 21
<212> PRT
<213> Homo sapiens

<400> 435
Val Ala Leu Trp Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys 
1               5                   10                  15      


Ala Met Ala Leu Leu 
            20      


<210> 436
<211> 21
<212> PRT
<213> Homo sapiens

<400> 436
Leu Leu Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr 
1               5                   10                  15      


Val Val Ser Phe Tyr 
            20      


<210> 437
<211> 21
<212> PRT
<213> Homo sapiens

<400> 437
Phe Cys Ser Ile Val Met Leu Leu Phe Leu Cys Ser Phe Ser Trp Leu 
1               5                   10                  15      


Ile Phe Ile Phe Leu 
            20      


<210> 438
<211> 45
<212> PRT
<213> Homo sapiens

<400> 438
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210> 439
<211> 55
<212> PRT
<213> Homo sapiens

<400> 439
Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp 
    50                  55  


<210> 440
<211> 232
<212> PRT
<213> Homo sapiens

<400> 440
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210> 441
<211> 236
<212> PRT
<213> Homo sapiens

<400> 441
Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Glu 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys 
225                 230                 235     


<210> 442
<211> 39
<212> PRT
<213> Homo sapiens

<400> 442
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro 
        35                  


<210> 443
<211> 16
<212> PRT
<213> Homo sapiens

<400> 443
Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn Pro Arg His Leu His 
1               5                   10                  15      


<210> 444
<211> 12
<212> PRT
<213> Homo sapiens

<400> 444
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210> 445
<211> 229
<212> PRT
<213> Homo sapiens

<400> 445
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210> 446
<211> 16
<212> PRT
<213> Homo sapiens

<400> 446
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
1               5                   10                  15      


<210> 447
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 447
Gly Gly Gly Gly Ser 
1               5   


<210> 448
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 448
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 449
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 449
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 450
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 450
Gly Gly Ser Gly Gly Ser Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr 
1               5                   10                  15      


Ala Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25  


<210> 451
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 451
Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  


<210> 452
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 452
Gly Gly Ser Gly Gly Ser Gly Gly Gly Pro Glu Asp Glu Pro Gly Ser 
1               5                   10                  15      


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25      


<210> 453
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 453
Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            20                  25                  30          


Glu Asp Gly Ser Gly Ser Gly Ser Gly Ser 
        35                  40          


<210> 454
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 454
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Glu Asp Glu Asp Glu Asp 
1               5                   10                  15      


Glu Asp Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            20                  25              


<210> 455
<211> 1
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 455
Ser 
1   


<210> 456
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 456
Gly Ser Gly Ser Gly Ser Gly Ser Glu Asp Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser 
        


<210> 457
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 457
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser 
        


<210> 458
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 458
Gly Cys Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 459
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 459
Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  


<210> 460
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 460
Ser Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Ser Pro Ala 
            20                  25      


<210> 461
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 461
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  


<210> 462
<211> 58
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 462
Ser Gly Arg Gly Ala Ser Ser Gly Ser Ser Gly Ser Gly Ser Gln Lys 
1               5                   10                  15      


Lys Pro Arg Tyr Glu Ile Arg Trp Lys Val Val Val Ile Ser Ala Ile 
            20                  25                  30          


Leu Ala Leu Val Val Leu Thr Val Ile Ser Leu Ile Ile Leu Ile Met 
        35                  40                  45              


Leu Trp Gly Ser Gly Met Gln Ser Pro Ala 
    50                  55              


<210> 463
<211> 30
<212> PRT
<213> Homo sapiens

<400> 463
Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly 
            20                  25                  30  


<210> 464
<211> 24
<212> PRT
<213> Homo sapiens

<400> 464
Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly 
            20                  


<210> 465
<211> 28
<212> PRT
<213> Homo sapiens

<400> 465
Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Ala Ser Ser Ser Leu Cys 
            20                  25              


<210> 466
<211> 17
<212> PRT
<213> Homo sapiens

<400> 466
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met 
    


<210> 467
<211> 34
<212> PRT
<213> Homo sapiens

<400> 467
Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala 
        


<210> 468
<211> 35
<212> PRT
<213> Homo sapiens

<400> 468
Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys 
        35  


<210> 469
<211> 25
<212> PRT
<213> Homo sapiens

<400> 469
Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala 
            20                  25  


<210> 470
<211> 19
<212> PRT
<213> Homo sapiens

<400> 470
Met Leu Leu Trp Thr Ala Val Leu Leu Phe Val Pro Cys Val Gly Lys 
1               5                   10                  15      


Thr Val Trp 
            


<210> 471
<211> 21
<212> PRT
<213> Homo sapiens

<400> 471
Met Leu Pro Cys Leu Val Val Leu Leu Ala Ala Leu Leu Ser Leu Arg 
1               5                   10                  15      


Leu Gly Ser Asp Ala 
            20      


<210> 472
<211> 19
<212> PRT
<213> Homo sapiens

<400> 472
Met Ala Trp Ser Leu Gly Ser Trp Leu Gly Gly Cys Leu Leu Val Ser 
1               5                   10                  15      


Ala Leu Gly 
            


<210> 473
<211> 19
<212> PRT
<213> Homo sapiens

<400> 473
Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala 
            


<210> 474
<211> 22
<212> PRT
<213> Homo sapiens

<400> 474
Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly 
            20          


<210> 475
<211> 21
<212> PRT
<213> Homo sapiens

<400> 475
Met Ser Leu Leu Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro 
            20      


<210> 476
<211> 21
<212> PRT
<213> Homo sapiens

<400> 476
Met Ser Leu Met Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro 
            20      


<210> 477
<211> 21
<212> PRT
<213> Homo sapiens

<400> 477
Met Ser Leu Met Val Val Ser Met Val Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro 
            20      


<210> 478
<211> 21
<212> PRT
<213> Homo sapiens

<400> 478
Met Ser Leu Met Val Ile Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Thr 
            20      


<210> 479
<211> 21
<212> PRT
<213> Homo sapiens

<400> 479
Met Ser Leu Met Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Thr 
            20      


<210> 480
<211> 21
<212> PRT
<213> Homo sapiens

<400> 480
Met Ser Leu Met Val Val Ser Met Ala Cys Val Gly Leu Phe Leu Val 
1               5                   10                  15      


Gln Arg Ala Gly Pro 
            20      


<210> 481
<211> 21
<212> PRT
<213> Homo sapiens

<400> 481
Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro 
            20      


<210> 482
<211> 25
<212> PRT
<213> Homo sapiens

<400> 482
Met Ser Leu Met Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Glu Gly Pro Trp Pro His Val Gly Gly 
            20                  25  


<210> 483
<211> 22
<212> PRT
<213> Homo sapiens

<400> 483
Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro 
            20          


<210> 484
<211> 23
<212> PRT
<213> Homo sapiens

<400> 484
Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala 
            20              


<210> 485
<211> 21
<212> PRT
<213> Homo sapiens

<400> 485
Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val 
            20      


<210> 486
<211> 23
<212> PRT
<213> Homo sapiens

<400> 486
Met Thr Pro Ala Leu Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Val Gln Ala 
            20              


<210> 487
<211> 21
<212> PRT
<213> Homo sapiens

<400> 487
Met Ile Pro Thr Phe Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Met 
            20      


<210> 488
<211> 23
<212> PRT
<213> Homo sapiens

<400> 488
Met Thr Leu Thr Leu Ser Val Leu Ile Cys Leu Gly Leu Ser Val Gly 
1               5                   10                  15      


Pro Arg Thr Cys Val Gln Ala 
            20              


<210> 489
<211> 18
<212> PRT
<213> Homo sapiens

<400> 489
Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala 
        


<210> 490
<211> 23
<212> PRT
<213> Homo sapiens

<400> 490
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp 
            20              


<210> 491
<211> 16
<212> PRT
<213> Homo sapiens

<400> 491
Met Leu Leu Pro Leu Leu Leu Ser Ser Leu Leu Gly Gly Ser Gln Ala 
1               5                   10                  15      


<210> 492
<211> 18
<212> PRT
<213> Homo sapiens

<400> 492
Met Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Val 
1               5                   10                  15      


Glu Gly 
        


<210> 493
<211> 17
<212> PRT
<213> Homo sapiens

<400> 493
Met Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala Glu 
1               5                   10                  15      


Gly 
    


<210> 494
<211> 21
<212> PRT
<213> Homo sapiens

<400> 494
Met Glu Lys Lys Trp Lys Tyr Cys Ala Val Tyr Tyr Ile Ile Gln Ile 
1               5                   10                  15      


His Phe Val Lys Gly 
            20      


<210> 495
<211> 33
<212> PRT
<213> Homo sapiens

<400> 495
Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala 
    


<210> 496
<211> 22
<212> PRT
<213> Homo sapiens

<400> 496
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser 
            20          


<210> 497
<211> 21
<212> PRT
<213> Homo sapiens

<400> 497
Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly 
            20      


<210> 498
<211> 21
<212> PRT
<213> Homo sapiens

<400> 498
Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser 
            20      


<210> 499
<211> 503
<212> PRT
<213> Homo sapiens

<400> 499
Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Cys His Asn Arg Thr Val Ile His His Arg Val Pro Asn 
145                 150                 155                 160 


Glu Glu Asp Pro Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr 
                165                 170                 175     


Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile Val Leu Gln 
        195                 200                 205             


Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp 
    210                 215                 220                 


Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg 
225                 230                 235                 240 


Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His 
                245                 250                 255     


Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr 
            260                 265                 270         


Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu 
        275                 280                 285             


Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys 
    290                 295                 300                 


Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His Met Glu Ile 
305                 310                 315                 320 


Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser 
                325                 330                 335     


Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu 
            340                 345                 350         


Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala 
        355                 360                 365             


Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu 
    370                 375                 380                 


Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Asp 
385                 390                 395                 400 


Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg Arg Cys Ser 
                405                 410                 415     


Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val 
            420                 425                 430         


Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln 
        435                 440                 445             


Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu 
    450                 455                 460                 


Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala 
465                 470                 475                 480 


Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser 
                485                 490                 495     


Gln Gln Glu Gly Ile Lys Met 
            500             


<210> 500
<211> 567
<212> PRT
<213> Homo sapiens

<400> 500
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210> 501
<211> 162
<212> PRT
<213> Homo sapiens

<400> 501
Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210> 502
<211> 161
<212> PRT
<213> Homo sapiens

<400> 502
Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu 
1               5                   10                  15      


Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His Val 
            20                  25                  30          


Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn 
        35                  40                  45              


Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln 
    50                  55                  60                  


Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro 
65                  70                  75                  80  


Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val 
                85                  90                  95      


Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn 
            100                 105                 110         


Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr 
        115                 120                 125             


Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys 
    130                 135                 140                 


Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr 
145                 150                 155                 160 


Ser 
    


<210> 503
<211> 114
<212> PRT
<213> Homo sapiens

<400> 503
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 504
<211> 267
<212> PRT
<213> Homo sapiens

<400> 504
Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210> 505
<211> 266
<212> PRT
<213> Homo sapiens

<400> 505
Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr Cys 
            20                  25                  30          


Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr 
        35                  40                  45              


Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg 
    50                  55                  60                  


Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr 
65                  70                  75                  80  


Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro 
                85                  90                  95      


Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala 
            100                 105                 110         


Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro 
        115                 120                 125             


Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala 
    130                 135                 140                 


Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly 
145                 150                 155                 160 


Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln 
                165                 170                 175     


Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro 
            180                 185                 190         


Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser 
        195                 200                 205             


Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala 
    210                 215                 220                 


Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met 
225                 230                 235                 240 


Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp 
                245                 250                 255     


Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265     


<210> 506
<211> 237
<212> PRT
<213> Homo sapiens

<400> 506
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val 
                165                 170                 175     


Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser 
            180                 185                 190         


Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser 
        195                 200                 205             


Val Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser 
    210                 215                 220                 


Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
225                 230                 235         


<210> 507
<211> 402
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 507
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu His 
                165                 170                 175     


Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr 
            180                 185                 190         


Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr 
        195                 200                 205             


Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro 
    210                 215                 220                 


Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala 
225                 230                 235                 240 


Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser 
                245                 250                 255     


Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn 
            260                 265                 270         


Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met 
        275                 280                 285             


Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu 
    290                 295                 300                 


Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu 
305                 310                 315                 320 


Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His 
                325                 330                 335     


Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly 
            340                 345                 350         


Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr 
        355                 360                 365             


Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met Glu Ala Leu Pro Val 
    370                 375                 380                 


Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser His 
385                 390                 395                 400 


His Leu 
        


<210> 508
<211> 201
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 508
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    130                 135                 140                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
145                 150                 155                 160 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                165                 170                 175     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            180                 185                 190         


Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        195                 200     


<210> 509
<211> 224
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 509
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser 
                165                 170                 175     


Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro 
            180                 185                 190         


Leu Ala Ser Val Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp 
        195                 200                 205             


Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
    210                 215                 220                 


<210> 510
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 510
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210> 511
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 511
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 512
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 512
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210> 513
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 513
Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210> 514
<211> 636
<212> PRT
<213> Tribolium castaneum

<400> 514
Met Met Leu Asn Trp Leu Lys Ser Gly Lys Leu Glu Ser Gln Ser Gln 
1               5                   10                  15      


Glu Gln Ser Ser Cys Tyr Leu Glu Asn Ser Asn Cys Leu Pro Pro Thr 
            20                  25                  30          


Leu Asp Ser Thr Asp Ile Ile Gly Glu Glu Asn Lys Ala Gly Thr Thr 
        35                  40                  45              


Ser Arg Lys Lys Arg Lys Tyr Asp Glu Asp Tyr Leu Asn Phe Gly Phe 
    50                  55                  60                  


Thr Trp Thr Gly Asp Lys Asp Glu Pro Asn Gly Leu Cys Val Ile Cys 
65                  70                  75                  80  


Glu Gln Val Val Asn Asn Ser Ser Leu Asn Pro Ala Lys Leu Lys Arg 
                85                  90                  95      


His Leu Asp Thr Lys His Pro Thr Leu Lys Gly Lys Ser Glu Tyr Phe 
            100                 105                 110         


Lys Arg Lys Cys Asn Glu Leu Asn Gln Lys Lys His Thr Phe Glu Arg 
        115                 120                 125             


Tyr Val Arg Asp Asp Asn Lys Asn Leu Leu Lys Ala Ser Tyr Leu Val 
    130                 135                 140                 


Ser Leu Arg Ile Ala Lys Gln Gly Glu Ala Tyr Thr Ile Ala Glu Lys 
145                 150                 155                 160 


Leu Ile Lys Pro Cys Thr Lys Asp Leu Thr Thr Cys Val Phe Gly Glu 
                165                 170                 175     


Lys Phe Ala Ser Lys Val Asp Leu Val Pro Leu Ser Asp Thr Thr Ile 
            180                 185                 190         


Ser Arg Arg Ile Glu Asp Met Ser Tyr Phe Cys Glu Ala Val Leu Val 
        195                 200                 205             


Asn Arg Leu Glu Asn Ala Lys Cys Gly Phe Thr Leu Gln Met Asp Glu 
    210                 215                 220                 


Ser Thr Asp Val Ala Gly Leu Ala Ile Leu Leu Val Phe Val Arg Tyr 
225                 230                 235                 240 


Ile His Glu Ser Ser Phe Glu Glu Asp Met Leu Phe Cys Lys Ala Leu 
                245                 250                 255     


Pro Thr Gln Thr Thr Gly Glu Glu Ile Phe Asn Leu Leu Asn Ala Tyr 
            260                 265                 270         


Phe Glu Lys His Ser Ile Pro Trp Asn Leu Cys Tyr His Ile Cys Thr 
        275                 280                 285             


Asp Gly Ala Lys Ala Met Val Gly Val Ile Lys Gly Val Ile Ala Arg 
    290                 295                 300                 


Ile Lys Lys Leu Val Pro Asp Ile Lys Ala Ser His Cys Cys Leu His 
305                 310                 315                 320 


Arg His Ala Leu Ala Val Lys Arg Ile Pro Asn Ala Leu His Glu Val 
                325                 330                 335     


Leu Asn Asp Ala Val Lys Met Ile Asn Phe Ile Lys Ser Arg Pro Leu 
            340                 345                 350         


Asn Ala Arg Val Phe Ala Leu Leu Cys Asp Asp Leu Gly Ser Leu His 
        355                 360                 365             


Lys Asn Leu Leu Leu His Thr Glu Val Arg Trp Leu Ser Arg Gly Lys 
    370                 375                 380                 


Val Leu Thr Arg Phe Trp Glu Leu Arg Asp Glu Ile Arg Ile Phe Phe 
385                 390                 395                 400 


Asn Glu Arg Glu Phe Ala Gly Lys Leu Asn Asp Thr Ser Trp Leu Gln 
                405                 410                 415     


Asn Leu Ala Tyr Ile Ala Asp Ile Phe Ser Tyr Leu Asn Glu Val Asn 
            420                 425                 430         


Leu Ser Leu Gln Gly Pro Asn Ser Thr Ile Phe Lys Val Asn Ser Arg 
        435                 440                 445             


Ile Asn Ser Ile Lys Ser Lys Leu Lys Leu Trp Glu Glu Cys Ile Thr 
    450                 455                 460                 


Lys Asn Asn Thr Glu Cys Phe Ala Asn Leu Asn Asp Phe Leu Glu Thr 
465                 470                 475                 480 


Ser Asn Thr Ala Leu Asp Pro Asn Leu Lys Ser Asn Ile Leu Glu His 
                485                 490                 495     


Leu Asn Gly Leu Lys Asn Thr Phe Leu Glu Tyr Phe Pro Pro Thr Cys 
            500                 505                 510         


Asn Asn Ile Ser Trp Val Glu Asn Pro Phe Asn Glu Cys Gly Asn Val 
        515                 520                 525             


Asp Thr Leu Pro Ile Lys Glu Arg Glu Gln Leu Ile Asp Ile Arg Thr 
    530                 535                 540                 


Asp Thr Thr Leu Lys Ser Ser Phe Val Pro Asp Gly Ile Gly Pro Phe 
545                 550                 555                 560 


Trp Ile Lys Leu Met Asp Glu Phe Pro Glu Ile Ser Lys Arg Ala Val 
                565                 570                 575     


Lys Glu Leu Met Pro Phe Val Thr Thr Tyr Leu Cys Glu Lys Ser Phe 
            580                 585                 590         


Ser Val Tyr Val Ala Thr Lys Thr Lys Tyr Arg Asn Arg Leu Asp Ala 
        595                 600                 605             


Glu Asp Asp Met Arg Leu Gln Leu Thr Thr Ile His Pro Asp Ile Asp 
    610                 615                 620                 


Asn Leu Cys Asn Asn Lys Gln Ala Gln Lys Ser His 
625                 630                 635     


<210> 515
<211> 636
<212> PRT
<213> Tribolium castaneum

<400> 515
Met Met Leu Asn Trp Leu Lys Ser Gly Lys Leu Glu Ser Gln Ser Gln 
1               5                   10                  15      


Glu Gln Ser Ser Cys Tyr Leu Glu Asn Ser Asn Cys Leu Pro Pro Thr 
            20                  25                  30          


Leu Asp Ser Thr Asp Ile Ile Gly Glu Glu Asn Lys Ala Gly Thr Thr 
        35                  40                  45              


Ser Arg Lys Lys Arg Lys Tyr Asp Glu Asp Tyr Leu Asn Phe Gly Phe 
    50                  55                  60                  


Thr Trp Thr Gly Asp Lys Asp Glu Pro Asn Gly Leu Cys Val Ile Cys 
65                  70                  75                  80  


Glu Gln Val Val Asn Asn Ser Ser Leu Asn Pro Ala Lys Leu Lys Arg 
                85                  90                  95      


His Leu Asp Thr Lys His Pro Thr Leu Lys Gly Lys Ser Glu Tyr Phe 
            100                 105                 110         


Lys Arg Lys Cys Asn Glu Leu Asn Gln Lys Lys His Thr Phe Glu Arg 
        115                 120                 125             


Tyr Val Arg Asp Asp Asn Lys Asn Leu Leu Lys Ala Ser Tyr Leu Val 
    130                 135                 140                 


Ser Leu Arg Ile Ala Lys Gln Gly Glu Ala Tyr Thr Ile Ala Glu Lys 
145                 150                 155                 160 


Leu Ile Lys Pro Cys Thr Lys Asp Leu Thr Thr Cys Val Phe Gly Glu 
                165                 170                 175     


Lys Phe Ala Ser Lys Val Asp Leu Val Pro Leu Ser Asp Thr Thr Ile 
            180                 185                 190         


Ser Arg Arg Ile Glu Asp Met Ser Tyr Phe Cys Glu Ala Val Leu Val 
        195                 200                 205             


Asn Arg Leu Glu Asn Ala Lys Cys Gly Phe Thr Leu Gln Met Asp Glu 
    210                 215                 220                 


Ser Thr Asp Val Ala Gly Leu Ala Ile Leu Leu Val Phe Val Arg Tyr 
225                 230                 235                 240 


Ile His Glu Ser Ser Phe Glu Glu Asp Met Leu Phe Cys Lys Ala Leu 
                245                 250                 255     


Pro Thr Gln Thr Thr Gly Glu Glu Ile Phe Asn Leu Leu Asn Ala Tyr 
            260                 265                 270         


Phe Glu Lys His Ser Ile Pro Trp Asn Leu Cys Tyr His Ile Cys Thr 
        275                 280                 285             


Asp Gly Ala Lys Ala Met Val Gly Val Ile Lys Gly Val Ile Ala Arg 
    290                 295                 300                 


Ile Lys Lys Leu Val Pro Asp Ile Lys Ala Ser His Cys Cys Leu His 
305                 310                 315                 320 


Arg His Ala Leu Ala Val Lys Arg Ile Pro Asn Ala Leu His Glu Val 
                325                 330                 335     


Leu Asn Asp Ala Val Lys Met Ile Asn Phe Ile Lys Ser Arg Pro Leu 
            340                 345                 350         


Asn Ala Arg Val Phe Ala Leu Leu Cys Asp Asp Leu Gly Ser Leu His 
        355                 360                 365             


Lys Asn Leu Leu Leu His Thr Glu Val Arg Trp Leu Ser Arg Gly Lys 
    370                 375                 380                 


Val Leu Thr Arg Phe Trp Glu Leu Arg Asp Glu Ile Arg Ile Phe Phe 
385                 390                 395                 400 


Asn Glu Arg Glu Phe Ala Gly Lys Leu Asn Asp Thr Ser Trp Leu Gln 
                405                 410                 415     


Asn Leu Ala Tyr Ile Ala Asp Ile Phe Ser Tyr Leu Asn Glu Val Asn 
            420                 425                 430         


Leu Ser Leu Gln Gly Pro Asn Ser Thr Ile Phe Lys Val Asn Ser Arg 
        435                 440                 445             


Ile Asn Ser Ile Lys Ser Lys Leu Lys Leu Trp Glu Glu Cys Ile Thr 
    450                 455                 460                 


Lys Asn Asn Thr Glu Cys Phe Ala Asn Leu Asn Asp Phe Leu Glu Thr 
465                 470                 475                 480 


Ser Asn Thr Ala Leu Asp Pro Asn Leu Lys Ser Asn Ile Leu Glu His 
                485                 490                 495     


Leu Asn Gly Leu Lys Asn Thr Phe Leu Glu Tyr Phe Pro Pro Thr Cys 
            500                 505                 510         


Asn Asn Ile Ser Trp Val Glu Asn Pro Phe Asn Glu Cys Gly Asn Val 
        515                 520                 525             


Asp Thr Leu Pro Ile Lys Glu Arg Glu Gln Leu Ile Asp Ile Arg Thr 
    530                 535                 540                 


Asp Thr Thr Leu Lys Ser Ser Phe Val Pro Asp Gly Ile Gly Pro Phe 
545                 550                 555                 560 


Trp Ile Lys Leu Met Asp Glu Phe Pro Glu Ile Ser Lys Arg Ala Val 
                565                 570                 575     


Lys Glu Leu Met Pro Phe Val Thr Thr Tyr Leu Cys Glu Lys Ser Phe 
            580                 585                 590         


Ser Val Tyr Val Ala Thr Lys Thr Lys Tyr Arg Asn Arg Leu Asp Ala 
        595                 600                 605             


Glu Asp Asp Met Arg Leu Gln Leu Thr Thr Ile His Pro Asp Ile Asp 
    610                 615                 620                 


Asn Leu Cys Asn Asn Lys Gln Ala Gln Lys Ser His 
625                 630                 635     


<210> 516
<211> 1911
<212> DNA
<213> Tribolium castaneum

<400> 516
atgatgttga attggctgaa aagtggaaag cttgaaagtc aatcacagga acagagttcc       60

tgctaccttg agaactctaa ctgcctgcca ccaacgctcg attctacaga tattatcggt      120

gaagagaaca aagctggtac cacctctcgc aagaagcgga aatatgacga ggactatctg      180

aacttcggtt ttacatggac tggcgacaag gatgagccca acggactttg tgtgatttgc      240

gagcaggtag tcaacaattc ctcacttaac ccggccaaac tgaaacgcca tttggacaca      300

aagcatccga cgcttaaagg caagagcgaa tacttcaaaa gaaaatgtaa cgagctcaat      360

caaaagaagc atacttttga gcgatacgta agggacgata acaagaacct cctgaaagct      420

tcttatctcg tcagtttgag aatagctaaa cagggcgagg catataccat agcggagaag      480

ttgatcaagc cttgcaccaa ggatctgaca acttgcgtat ttggagaaaa attcgcgagc      540

aaagttgatc tcgtccccct gtccgacacg actatttcaa ggcgaatcga agacatgagt      600

tacttctgtg aagccgtgct ggtgaacagg ttgaaaaatg ctaaatgtgg gtttacgctg      660

cagatggacg agtcaacaga tgttgccggt cttgcaatcc tgcttgtgtt tgttaggtac      720

atacatgaaa gctcttttga ggaggatatg ttgttctgca aagcacttcc cactcagacg      780

acaggggagg agattttcaa tcttctcaat gcctatttcg aaaagcactc catcccatgg      840

aatctgtgtt accacatttg cacagacggt gccaaggcaa tggtaggagt tattaaagga      900

gtcatagcga gaataaaaaa actcgtccct gatataaaag ctagccactg ttgcctgcat      960

cgccacgctt tggctgtaaa gcgaataccg aatgcattgc acgaggtgct caatgacgct     1020

gttaaaatga tcaacttcat caagtctcgg ccgttgaatg cgcgcgtctt cgctttgctg     1080

tgtgacgatt tggggagcct gcataaaaat cttcttcttc ataccgaagt gaggtggctg     1140

tctagaggaa aggtgctgac ccgattttgg gaactgagag atgaaattag aattttcttc     1200

aacgaaaggg aatttgccgg gaaattgaac gacaccagtt ggttgcaaaa tttggcatat     1260

atagctgaca tattcagtta tctgaatgaa gttaatcttt ccctgcaagg gccgaatagc     1320

acaatcttca aggtaaatag ccgcattaac agtattaaat caaagttgaa gttgtgggaa     1380

gagtgtataa cgaaaaataa cactgagtgt tttgcgaacc tcaacgattt tttggaaact     1440

tcaaacactg cgttggatcc aaacctgaag tctaatattt tggaacatct caacggtctt     1500

aagaacacct ttctggagta ttttccacct acgtgtaata atatctcctg ggtggagaat     1560

cctttcaatg aatgcggtaa cgtcgataca ctcccaataa aagagaggga acaattgatt     1620

gacatacgga ctgatacgac attgaaatct tcattcgtgc ctgatggtat aggaccattc     1680

tggatcaaac tgatggacga atttccagaa attagcaaac gagctgtcaa agagctcatg     1740

ccatttgtaa ccacttacct ctgtgagaaa tcattttccg tctatgtagc cacaaaaaca     1800

aaatatcgaa atagacttga tgctgaagac gatatgcgac tccaacttac tactatccat     1860

ccagacattg acaacctttg taacaacaag caggctcaga aatcccactg a              1911


<210> 517
<211> 1911
<212> DNA
<213> Tribolium castaneum

<400> 517
atgatgttga attggctgaa aagtggaaag cttgaaagtc aatcacagga acagagttcc       60

tgctaccttg agaactctaa ctgcctgcca ccaacgctcg attctacaga tattatcggt      120

gaagagaaca aagctggtac cacctctcgc aagaagcgga aatatgacga ggactatctg      180

aacttcggtt ttacatggac tggcgacaag gatgagccca acggactttg tgtgatttgc      240

gagcaggtag tcaacaattc ctcacttaac ccggccaaac tgaaacgcca tttggacaca      300

aagcatccga cgcttaaagg caagagcgaa tacttcaaaa gaaaatgtaa cgagctcaat      360

caaaagaagc atacttttga gcgatacgta agggacgata acaagaacct cctgaaagct      420

tcttatctcg tcagtttgag aatagctaaa cagggcgagg catataccat agcggagaag      480

ttgatcaagc cttgcaccaa ggatctgaca acttgcgtat ttggagaaaa attcgcgagc      540

aaagttgatc tcgtccccct gtccgacacg actatttcaa ggcgaatcga agacatgagt      600

tacttctgtg aagccgtgct ggtgaacagg ttgaaaaatg ctaaatgtgg gtttacgctg      660

cagatggacg agtcaacaga tgttgccggt cttgcaatcc tgcttgtgtt tgttaggtac      720

atacatgaaa gctcttttga ggaggatatg ttgttctgca aagcacttcc cactcagacg      780

acaggggagg agattttcaa tcttctcaat gcctatttcg aaaagcactc catcccatgg      840

aatctgtgtt accacatttg cacagacggt gccaaggcaa tggtaggagt tattaaagga      900

gtcatagcga gaataaaaaa actcgtccct gatataaaag ctagccactg ttgcctgcat      960

cgccacgctt tggctgtaaa gcgaataccg aatgcattgc acgaggtgct caatgacgct     1020

gttaaaatga tcaacttcat caagtctcgg ccgttgaatg cgcgcgtctt cgctttgctg     1080

tgtgacgatt tggggagcct gcataaaaat cttcttcttc ataccgaagt gaggtggctg     1140

tctagaggaa aggtgctgac ccgattttgg gaactgagag atgaaattag aattttcttc     1200

aacgaaaggg aatttgccgg gaaattgaac gacaccagtt ggttgcaaaa tttggcatat     1260

atagctgaca tattcagtta tctgaatgaa gttaatcttt ccctgcaagg gccgaatagc     1320

acaatcttca aggtaaatag ccgcattaac agtattaaat caaagttgaa gttgtgggaa     1380

gagtgtataa cgaaaaataa cactgagtgt tttgcgaacc tcaacgattt tttggaaact     1440

tcaaacactg cgttggatcc aaacctgaag tctaatattt tggaacatct caacggtctt     1500

aagaacacct ttctggagta ttttccacct acgtgtaata atatctcctg ggtggagaat     1560

cctttcaatg aatgcggtaa cgtcgataca ctcccaataa aagagaggga acaattgatt     1620

gacatacgga ctgatacgac attgaaatct tcattcgtgc ctgatggtat aggaccattc     1680

tggatcaaac tgatggacga atttccagaa attagcaaac gagctgtcaa agagctcatg     1740

ccatttgtaa ccacttacct ctgtgagaaa tcattttccg tctatgtagc cacaaaaaca     1800

aaatatcgaa atagacttga tgctgaagac gatatgcgac tccaacttac tactatccat     1860

ccagacattg acaacctttg taacaacaag caggctcaga aatcccactg a              1911


<210> 518
<211> 206
<212> PRT
<213> Staphylococcus aureus

<400> 518
Met Lys Lys Trp Thr Asn Arg Leu Met Thr Ile Ala Gly Val Val Leu 
1               5                   10                  15      


Ile Leu Val Ala Ala Tyr Leu Phe Ala Lys Pro His Ile Asp Asn Tyr 
            20                  25                  30          


Leu His Asp Lys Asp Lys Asp Glu Lys Ile Glu Gln Tyr Asp Lys Asn 
        35                  40                  45              


Val Lys Glu Gln Ala Ser Lys Asp Asn Lys Gln Gln Ala Lys Pro Gln 
    50                  55                  60                  


Ile Pro Lys Asp Lys Ser Lys Val Ala Gly Tyr Ile Glu Ile Pro Asp 
65                  70                  75                  80  


Ala Asp Ile Lys Glu Pro Val Tyr Pro Gly Pro Ala Thr Pro Glu Gln 
                85                  90                  95      


Leu Asn Arg Gly Val Ser Phe Ala Glu Glu Asn Glu Ser Leu Asp Asp 
            100                 105                 110         


Gln Asn Ile Ser Ile Ala Gly His Thr Phe Ile Asp Arg Pro Asn Tyr 
        115                 120                 125             


Gln Phe Thr Asn Leu Lys Ala Ala Lys Lys Gly Ser Met Val Tyr Phe 
    130                 135                 140                 


Lys Val Gly Asn Glu Thr Arg Lys Tyr Lys Met Thr Ser Ile Arg Asp 
145                 150                 155                 160 


Val Lys Pro Thr Asp Val Glu Val Leu Asp Glu Gln Lys Gly Lys Asp 
                165                 170                 175     


Lys Gln Leu Thr Leu Ile Thr Cys Asp Asp Tyr Asn Glu Lys Thr Gly 
            180                 185                 190         


Val Trp Glu Lys Arg Lys Ile Phe Val Ala Thr Glu Val Lys 
        195                 200                 205     


<210> 519
<211> 156
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 519
Met Gln Ala Lys Pro Gln Ile Pro Lys Asp Lys Ser Lys Val Ala Gly 
1               5                   10                  15      


Tyr Ile Glu Ile Pro Asp Ala Asp Ile Lys Glu Pro Val Tyr Pro Gly 
            20                  25                  30          


Pro Ala Thr Arg Glu Gln Leu Asn Arg Gly Val Ser Phe Ala Lys Glu 
        35                  40                  45              


Asn Gln Ser Leu Asp Asp Gln Asn Ile Ser Ile Ala Gly His Thr Phe 
    50                  55                  60                  


Ile Asp Arg Pro Asn Tyr Gln Phe Thr Asn Leu Lys Ala Ala Lys Lys 
65                  70                  75                  80  


Gly Ser Met Val Tyr Phe Lys Val Gly Asn Glu Thr Arg Lys Tyr Lys 
                85                  90                  95      


Met Thr Ser Ile Arg Asn Val Lys Pro Thr Ala Val Glu Val Leu Asp 
            100                 105                 110         


Glu Gln Lys Gly Lys Asp Lys Gln Leu Thr Leu Ile Thr Cys Asp Asp 
        115                 120                 125             


Tyr Asn Glu Glu Thr Gly Val Trp Glu Thr Arg Lys Ile Phe Val Ala 
    130                 135                 140                 


Thr Glu Val Lys Leu Glu His His His His His His 
145                 150                 155     


<210> 520
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 520
Leu Pro Xaa Thr Gly 
1               5   


<210> 521
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 521
Leu Pro Xaa Thr Ala 
1               5   


<210> 522
<211> 18
<212> DNA
<213> Homo sapiens

<400> 522
tgctgttgag gagctgga                                                     18


<210> 523
<211> 18
<212> DNA
<213> Homo sapiens

<400> 523
agcacaccag gcagagtt                                                     18


<210> 524
<211> 18
<212> DNA
<213> Homo sapiens

<400> 524
cggctgagga gcggaaga                                                     18


<210> 525
<211> 18
<212> DNA
<213> Homo sapiens

<400> 525
tggaggtgag caatcccc                                                     18


<210> 526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 526
ttaatacgac tcactatagg                                                   20


<210> 527
<211> 20
<212> DNA
<213> Homo sapiens

<400> 527
gttttagagc tagaaatagc                                                   20


<210> 528
<211> 240
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 528
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Val Tyr Phe Leu Gly 
            180                 185                 190         


Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg Lys 
        195                 200                 205             


Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln 
    210                 215                 220                 


Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
225                 230                 235                 240 


<210> 529
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 529
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Gly Val Leu Ala Gly Ile Val Met Gly Asp 
                165                 170                 175     


Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu Gly Arg 
            180                 185                 190         


Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg Lys Gln 
        195                 200                 205             


Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg 
    210                 215                 220                 


Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
225                 230                 235                 


<210> 530
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 530
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Leu Leu Ala Gly Leu Val Ala Ala Asp Ala 
                165                 170                 175     


Val Ala Ser Leu Leu Ile Val Gly Ala Val Phe Leu Cys Ala Arg Pro 
            180                 185                 190         


Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro 
        195                 200                 205             


Gly Arg Gly 
    210     


<210> 531
<211> 241
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 531
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu 
                165                 170                 175     


Pro Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser 
            180                 185                 190         


Leu Ser Leu Pro Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala 
        195                 200                 205             


Ser Leu Leu Ile Val Gly Ala Val Phe Leu Cys Ala Arg Pro Arg Arg 
    210                 215                 220                 


Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg 
225                 230                 235                 240 


Gly 
    


<210> 532
<211> 223
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 532
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Leu Cys Ala Arg Pro Arg Arg Ser Pro 
        195                 200                 205             


Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
    210                 215                 220             


<210> 533
<211> 227
<212> PRT
<213> Homo sapiens

<400> 533
Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Leu Leu Leu Gln Pro Pro 
1               5                   10                  15      


Ala Phe Leu Gln Pro Gly Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu 
            20                  25                  30          


Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser 
        35                  40                  45              


Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Ile Val 
    50                  55                  60                  


Pro Asn Val Arg Ile Ser Trp Arg Arg Gly His Phe His Gly Gln Ser 
65                  70                  75                  80  


Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg 
                85                  90                  95      


Leu Phe Leu Asn Trp Thr Glu Gly Gln Glu Ser Gly Phe Leu Arg Ile 
            100                 105                 110         


Ser Asn Leu Arg Lys Glu Asp Gln Ser Val Tyr Phe Cys Arg Val Glu 
        115                 120                 125             


Leu Asp Thr Arg Arg Ser Gly Arg Gln Gln Leu Gln Ser Ile Lys Gly 
    130                 135                 140                 


Thr Lys Leu Thr Ile Thr Gln Ala Val Thr Thr Thr Thr Thr Trp Arg 
145                 150                 155                 160 


Pro Ser Ser Thr Thr Thr Ile Ala Gly Leu Arg Val Thr Glu Ser Lys 
                165                 170                 175     


Gly His Ser Glu Ser Trp His Leu Ser Leu Asp Thr Ala Ile Arg Val 
            180                 185                 190         


Ala Leu Ala Val Ala Val Leu Lys Thr Val Ile Leu Gly Leu Leu Cys 
        195                 200                 205             


Leu Leu Leu Leu Trp Trp Arg Arg Arg Lys Gly Ser Arg Ala Pro Ser 
    210                 215                 220                 


Ser Asp Phe 
225         


<210> 534
<211> 21
<212> PRT
<213> Homo sapiens

<400> 534
Val Ala Leu Ala Val Ala Val Leu Lys Thr Val Ile Leu Gly Leu Leu 
1               5                   10                  15      


Cys Leu Leu Leu Leu 
            20      


<210> 535
<211> 15
<212> PRT
<213> Homo sapiens

<400> 535
Trp Trp Arg Arg Arg Lys Gly Ser Arg Ala Pro Ser Ser Asp Phe 
1               5                   10                  15  


<210> 536
<211> 598
<212> PRT
<213> Homo sapiens

<400> 536
Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn 
65                  70                  75                  80  


Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro 
            100                 105                 110         


Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys 
    130                 135                 140                 


Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu 
145                 150                 155                 160 


Glu Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser 
                165                 170                 175     


Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp 
            180                 185                 190         


Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser 
        195                 200                 205             


Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys 
    210                 215                 220                 


Pro Ser Leu Ser Val Gln Pro Gly Pro Val Val Ala Pro Gly Glu Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             


Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Cys Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 


Ile Arg Gly Thr Pro Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Ile His Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu 
385                 390                 395                 400 


Asn Ser Asp Pro Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Val Val Ser Gly Pro Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro 
            420                 425                 430         


Ile Ser Thr Pro Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
    450                 455                 460                 


Ile Leu Val Ala Val Val Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
465                 470                 475                 480 


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
                485                 490                 495     


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
            500                 505                 510         


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
        515                 520                 525             


Glu Glu Asn Leu Tyr Ala Ala Val Lys Asp Thr Gln Pro Glu Asp Gly 
    530                 535                 540                 


Val Glu Met Asp Thr Arg Ala Ala Ala Ser Glu Ala Pro Gln Asp Val 
545                 550                 555                 560 


Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu 
                565                 570                 575     


Pro Pro Pro Ser Gln Glu Arg Glu Pro Pro Ala Glu Pro Ser Ile Tyr 
            580                 585                 590         


Ala Thr Leu Ala Ile His 
        595             


<210> 537
<211> 440
<212> PRT
<213> Homo sapiens

<400> 537
Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser 
1               5                   10                  15      


Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu 
            20                  25                  30          


Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp 
        35                  40                  45              


Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile 
    50                  55                  60                  


Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr 
65                  70                  75                  80  


Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met 
                85                  90                  95      


Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val 
            100                 105                 110         


Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala 
        115                 120                 125             


Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Glu Glu His Pro Gln 
    130                 135                 140                 


Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe 
145                 150                 155                 160 


Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr 
                165                 170                 175     


Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu 
            180                 185                 190         


Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Leu Ser Val 
        195                 200                 205             


Gln Pro Gly Pro Val Val Ala Pro Gly Glu Ser Leu Thr Leu Gln Cys 
    210                 215                 220                 


Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr Lys Glu Gly Glu 
225                 230                 235                 240 


Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro Gln Ala Gly Leu Ser 
                245                 250                 255     


Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln 
            260                 265                 270         


Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Cys Ser Ala Pro 
        275                 280                 285             


Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln Ile Arg Gly Thr Pro 
    290                 295                 300                 


Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val 
305                 310                 315                 320 


Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His Thr Phe Leu Leu Thr 
                325                 330                 335     


Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu Arg Ser Ile His Glu 
            340                 345                 350         


Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Ala 
        355                 360                 365             


His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu Asn Ser Asp Pro Tyr 
    370                 375                 380                 


Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu Val Val Ser Gly Pro 
385                 390                 395                 400 


Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro Ile Ser Thr Pro Ala 
                405                 410                 415     


Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser 
            420                 425                 430         


Gly Leu Gly Arg His Leu Gly Val 
        435                 440 


<210> 538
<211> 147
<212> PRT
<213> Homo sapiens

<400> 538
Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile 
145         


<210> 539
<211> 503
<212> PRT
<213> Homo sapiens

<400> 539
Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Cys His Asn Arg Thr Val Ile His His Arg Val Pro Asn 
145                 150                 155                 160 


Glu Glu Asp Pro Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr 
                165                 170                 175     


Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile Val Leu Gln 
        195                 200                 205             


Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp 
    210                 215                 220                 


Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg 
225                 230                 235                 240 


Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His 
                245                 250                 255     


Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr 
            260                 265                 270         


Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu 
        275                 280                 285             


Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys 
    290                 295                 300                 


Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His Met Glu Ile 
305                 310                 315                 320 


Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser 
                325                 330                 335     


Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu 
            340                 345                 350         


Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala 
        355                 360                 365             


Pro Asn His Arg Val Gly Thr Glu Arg Tyr Met Ala Pro Glu Val Leu 
    370                 375                 380                 


Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Asp 
385                 390                 395                 400 


Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg Arg Cys Ser 
                405                 410                 415     


Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val 
            420                 425                 430         


Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln 
        435                 440                 445             


Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu 
    450                 455                 460                 


Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala 
465                 470                 475                 480 


Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser 
                485                 490                 495     


Gln Gln Glu Gly Ile Lys Met 
            500             


<210> 540
<211> 503
<212> PRT
<213> Homo sapiens

<400> 540
Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Cys His Asn Arg Thr Val Ile His His Arg Val Pro Asn 
145                 150                 155                 160 


Glu Glu Asp Pro Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr 
                165                 170                 175     


Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile Val Leu Gln 
        195                 200                 205             


Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp 
    210                 215                 220                 


Arg Gly Glu Glu Val Ala Val Arg Ile Phe Ser Ser Arg Glu Glu Arg 
225                 230                 235                 240 


Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His 
                245                 250                 255     


Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr 
            260                 265                 270         


Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu 
        275                 280                 285             


Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys 
    290                 295                 300                 


Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His Met Glu Ile 
305                 310                 315                 320 


Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser 
                325                 330                 335     


Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu 
            340                 345                 350         


Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala 
        355                 360                 365             


Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu 
    370                 375                 380                 


Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Asp 
385                 390                 395                 400 


Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg Arg Cys Ser 
                405                 410                 415     


Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val 
            420                 425                 430         


Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln 
        435                 440                 445             


Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu 
    450                 455                 460                 


Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala 
465                 470                 475                 480 


Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser 
                485                 490                 495     


Gln Gln Glu Gly Ile Lys Met 
            500             


<210> 541
<211> 503
<212> PRT
<213> Homo sapiens

<400> 541
Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Cys His Asn Arg Thr Val Ile His His Arg Val Pro Asn 
145                 150                 155                 160 


Glu Glu Asp Pro Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr 
                165                 170                 175     


Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Leu Pro Leu Leu Val Gln Arg Ile Ile Ala Arg Thr Ile Val Leu Gln 
        195                 200                 205             


Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp 
    210                 215                 220                 


Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg 
225                 230                 235                 240 


Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His 
                245                 250                 255     


Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr 
            260                 265                 270         


Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu 
        275                 280                 285             


Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys 
    290                 295                 300                 


Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His Met Glu Ile 
305                 310                 315                 320 


Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser 
                325                 330                 335     


Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu 
            340                 345                 350         


Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala 
        355                 360                 365             


Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu 
    370                 375                 380                 


Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Asp 
385                 390                 395                 400 


Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg Arg Cys Ser 
                405                 410                 415     


Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val 
            420                 425                 430         


Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln 
        435                 440                 445             


Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu 
    450                 455                 460                 


Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala 
465                 470                 475                 480 


Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser 
                485                 490                 495     


Gln Gln Glu Gly Ile Lys Met 
            500             


<210> 542
<211> 503
<212> PRT
<213> Homo sapiens

<400> 542
Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Cys His Asn Arg Thr Val Ile His His Arg Val Pro Asn 
145                 150                 155                 160 


Glu Glu Asp Pro Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr 
                165                 170                 175     


Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile Val Leu Gln 
        195                 200                 205             


Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp 
    210                 215                 220                 


Arg Gly Glu Glu Val Ala Val Glu Ile Phe Ser Ser Arg Glu Glu Arg 
225                 230                 235                 240 


Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His 
                245                 250                 255     


Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr 
            260                 265                 270         


Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu 
        275                 280                 285             


Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys 
    290                 295                 300                 


Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His Met Glu Ile 
305                 310                 315                 320 


Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser 
                325                 330                 335     


Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu 
            340                 345                 350         


Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala 
        355                 360                 365             


Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu 
    370                 375                 380                 


Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Asp 
385                 390                 395                 400 


Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg Arg Cys Ser 
                405                 410                 415     


Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val 
            420                 425                 430         


Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln 
        435                 440                 445             


Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu 
    450                 455                 460                 


Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala 
465                 470                 475                 480 


Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser 
                485                 490                 495     


Gln Gln Glu Gly Ile Lys Met 
            500             


<210> 543
<211> 503
<212> PRT
<213> Homo sapiens

<400> 543
Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Cys His Asn Arg Thr Val Ile His His Arg Val Pro Asn 
145                 150                 155                 160 


Glu Glu Asp Pro Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr 
                165                 170                 175     


Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile Val Leu Gln 
        195                 200                 205             


Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp 
    210                 215                 220                 


Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg 
225                 230                 235                 240 


Leu Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His 
                245                 250                 255     


Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr 
            260                 265                 270         


Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu 
        275                 280                 285             


Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys 
    290                 295                 300                 


Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His Met Glu Ile 
305                 310                 315                 320 


Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser 
                325                 330                 335     


Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu 
            340                 345                 350         


Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala 
        355                 360                 365             


Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu 
    370                 375                 380                 


Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Asp 
385                 390                 395                 400 


Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg Arg Cys Ser 
                405                 410                 415     


Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val 
            420                 425                 430         


Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln 
        435                 440                 445             


Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu 
    450                 455                 460                 


Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala 
465                 470                 475                 480 


Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser 
                485                 490                 495     


Gln Gln Glu Gly Ile Lys Met 
            500             


<210> 544
<211> 503
<212> PRT
<213> Homo sapiens

<400> 544
Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Cys His Asn Arg Thr Val Ile His His Arg Val Pro Asn 
145                 150                 155                 160 


Glu Glu Asp Pro Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr 
                165                 170                 175     


Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile Val Leu Gln 
        195                 200                 205             


Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp 
    210                 215                 220                 


Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg 
225                 230                 235                 240 


Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His 
                245                 250                 255     


Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr 
            260                 265                 270         


Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu 
        275                 280                 285             


Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys 
    290                 295                 300                 


Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His Arg Glu Ile 
305                 310                 315                 320 


Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser 
                325                 330                 335     


Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu 
            340                 345                 350         


Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala 
        355                 360                 365             


Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu 
    370                 375                 380                 


Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Asp 
385                 390                 395                 400 


Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg Arg Cys Ser 
                405                 410                 415     


Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val 
            420                 425                 430         


Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln 
        435                 440                 445             


Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu 
    450                 455                 460                 


Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala 
465                 470                 475                 480 


Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser 
                485                 490                 495     


Gln Gln Glu Gly Ile Lys Met 
            500             


<210> 545
<211> 503
<212> PRT
<213> Homo sapiens

<400> 545
Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Cys His Asn Arg Thr Val Ile His His Arg Val Pro Asn 
145                 150                 155                 160 


Glu Glu Asp Pro Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr 
                165                 170                 175     


Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile Val Leu Gln 
        195                 200                 205             


Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp 
    210                 215                 220                 


Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg 
225                 230                 235                 240 


Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His 
                245                 250                 255     


Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr 
            260                 265                 270         


Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu 
        275                 280                 285             


Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys 
    290                 295                 300                 


Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His Met Glu Ile 
305                 310                 315                 320 


Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser 
                325                 330                 335     


Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu 
            340                 345                 350         


Val Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala 
        355                 360                 365             


Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu 
    370                 375                 380                 


Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Asp 
385                 390                 395                 400 


Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg Arg Cys Ser 
                405                 410                 415     


Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val 
            420                 425                 430         


Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln 
        435                 440                 445             


Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu 
    450                 455                 460                 


Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala 
465                 470                 475                 480 


Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser 
                485                 490                 495     


Gln Gln Glu Gly Ile Lys Met 
            500             


<210> 546
<211> 503
<212> PRT
<213> Homo sapiens

<400> 546
Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Cys His Asn Arg Thr Val Ile His His Arg Val Pro Asn 
145                 150                 155                 160 


Glu Glu Asp Pro Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr 
                165                 170                 175     


Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile Val Leu Gln 
        195                 200                 205             


Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp 
    210                 215                 220                 


Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg 
225                 230                 235                 240 


Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His 
                245                 250                 255     


Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr 
            260                 265                 270         


Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu 
        275                 280                 285             


Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys 
    290                 295                 300                 


Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His Met Glu Ile 
305                 310                 315                 320 


Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser 
                325                 330                 335     


Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu 
            340                 345                 350         


Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala 
        355                 360                 365             


Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu 
    370                 375                 380                 


Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Gly 
385                 390                 395                 400 


Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg Arg Cys Ser 
                405                 410                 415     


Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val 
            420                 425                 430         


Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln 
        435                 440                 445             


Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu 
    450                 455                 460                 


Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala 
465                 470                 475                 480 


Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser 
                485                 490                 495     


Gln Gln Glu Gly Ile Lys Met 
            500             


<210> 547
<211> 503
<212> PRT
<213> Homo sapiens

<400> 547
Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Cys His Asn Arg Thr Val Ile His His Arg Val Pro Asn 
145                 150                 155                 160 


Glu Glu Asp Pro Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr 
                165                 170                 175     


Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile Val Leu Gln 
        195                 200                 205             


Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp 
    210                 215                 220                 


Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg 
225                 230                 235                 240 


Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His 
                245                 250                 255     


Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr 
            260                 265                 270         


Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu 
        275                 280                 285             


Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys 
    290                 295                 300                 


Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His Met Glu Ile 
305                 310                 315                 320 


Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser 
                325                 330                 335     


Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu 
            340                 345                 350         


Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala 
        355                 360                 365             


Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu 
    370                 375                 380                 


Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Asp 
385                 390                 395                 400 


Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg Arg Cys Ser 
                405                 410                 415     


Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val 
            420                 425                 430         


Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln 
        435                 440                 445             


Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu 
    450                 455                 460                 


Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala Pro Gly Ala 
465                 470                 475                 480 


Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser 
                485                 490                 495     


Gln Gln Glu Gly Ile Lys Met 
            500             


<210> 548
<211> 194
<212> PRT
<213> Homo sapiens

<400> 548
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln 
        


<210> 549
<211> 187
<212> PRT
<213> Homo sapiens

<400> 549
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr 
            180                 185         


<210> 550
<211> 567
<212> PRT
<213> Homo sapiens

<400> 550
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Cys Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210> 551
<211> 567
<212> PRT
<213> Homo sapiens

<400> 551
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala His 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210> 552
<211> 567
<212> PRT
<213> Homo sapiens

<400> 552
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Cys 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210> 553
<211> 567
<212> PRT
<213> Homo sapiens

<400> 553
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Cys Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210> 554
<211> 567
<212> PRT
<213> Homo sapiens

<400> 554
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser His Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210> 555
<211> 567
<212> PRT
<213> Homo sapiens

<400> 555
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu His Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210> 556
<211> 295
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 556
Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              


Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg Pro Ser 
    130                 135                 140                 


Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Leu Leu Pro 
145                 150                 155                 160 


Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu Phe Cys 
                165                 170                 175     


Cys Leu Arg Arg His Gln Gly Arg Val Lys Phe Ser Arg Ser Ala Asp 
            180                 185                 190         


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        195                 200                 205             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    210                 215                 220                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
225                 230                 235                 240 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                245                 250                 255     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            260                 265                 270         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        275                 280                 285             


Met Gln Ala Leu Pro Pro Arg 
    290                 295 


<210> 557
<211> 265
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 557
Lys Glu Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His 
1               5                   10                  15      


Ser Ile Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr 
            20                  25                  30          


Cys Ala Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr 
        35                  40                  45              


Cys Val Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn 
    50                  55                  60                  


Ile Ser Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn 
65                  70                  75                  80  


Gly Ser Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser 
                85                  90                  95      


His Ser Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg 
            100                 105                 110         


Pro Ser Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Leu 
        115                 120                 125             


Leu Pro Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu 
    130                 135                 140                 


Phe Cys Cys Leu Arg Arg His Gln Gly Arg Val Lys Phe Ser Arg Ser 
145                 150                 155                 160 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                165                 170                 175     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            180                 185                 190         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        195                 200                 205             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    210                 215                 220                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
225                 230                 235                 240 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                245                 250                 255     


Leu His Met Gln Ala Leu Pro Pro Arg 
            260                 265 


<210> 558
<211> 382
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 558
Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Ala Ser Ser Ser Leu Cys Met Asp Glu Lys 
            20                  25                  30          


Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu Val Asn Thr Ser 
        35                  40                  45              


Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys Cys Pro Pro Ile 
    50                  55                  60                  


Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile Ile Leu Arg Gly 
65                  70                  75                  80  


Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys Glu Thr Asn Glu Thr Lys 
                85                  90                  95      


Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val Ser Arg Pro Asp 
            100                 105                 110         


Gln Asn Ser Asp Leu Gln Ile Arg Pro Val Ala Ile Thr His Asp Gly 
        115                 120                 125             


Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn Phe His Arg Gly 
    130                 135                 140                 


Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr Leu Phe Gln Asn 
145                 150                 155                 160 


Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly Lys Pro Ala Ala 
                165                 170                 175     


Gln Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr Lys Gln Glu Tyr 
            180                 185                 190         


Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys His Trp Glu Val 
        195                 200                 205             


His Asn Val Ser Thr Val Thr Cys His Val Ser His Leu Thr Gly Asn 
    210                 215                 220                 


Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly Ala Lys Lys Ser 
225                 230                 235                 240 


Ala Lys Leu Tyr Ile Pro Tyr Ile Ile Leu Thr Ile Ile Ile Leu Thr 
                245                 250                 255     


Ile Val Gly Phe Ile Trp Leu Leu Lys Val Asn Gly Cys Arg Arg Val 
            260                 265                 270         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        275                 280                 285             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    290                 295                 300                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
305                 310                 315                 320 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                325                 330                 335     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            340                 345                 350         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        355                 360                 365             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    370                 375                 380         


<210> 559
<211> 354
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 559
Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu 
1               5                   10                  15      


Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys 
            20                  25                  30          


Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile 
        35                  40                  45              


Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys Glu Thr 
    50                  55                  60                  


Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val 
65                  70                  75                  80  


Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Pro Val Ala Ile 
                85                  90                  95      


Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn 
            100                 105                 110         


Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr 
        115                 120                 125             


Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly 
    130                 135                 140                 


Lys Pro Ala Ala Gln Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr 
145                 150                 155                 160 


Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys 
                165                 170                 175     


His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His Val Ser His 
            180                 185                 190         


Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly 
        195                 200                 205             


Ala Lys Lys Ser Ala Lys Leu Tyr Ile Pro Tyr Ile Ile Leu Thr Ile 
    210                 215                 220                 


Ile Ile Leu Thr Ile Val Gly Phe Ile Trp Leu Leu Lys Val Asn Gly 
225                 230                 235                 240 


Cys Arg Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
                245                 250                 255     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            260                 265                 270         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        275                 280                 285             


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    290                 295                 300                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
305                 310                 315                 320 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                325                 330                 335     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            340                 345                 350         


Pro Arg 
        


<210> 560
<211> 299
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 560
Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Arg Val Lys Phe Ser 
            180                 185                 190         


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        195                 200                 205             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    210                 215                 220                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
225                 230                 235                 240 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                245                 250                 255     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            260                 265                 270         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        275                 280                 285             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    290                 295                 


<210> 561
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 561
Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Phe Leu 
        115                 120                 125             


Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe Tyr Ser Phe 
    130                 135                 140                 


Leu Leu Thr Ala Val Ser Leu Ser Arg Val Lys Phe Ser Arg Ser Ala 
145                 150                 155                 160 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                165                 170                 175     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            180                 185                 190         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        195                 200                 205             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    210                 215                 220                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
225                 230                 235                 240 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                245                 250                 255     


His Met Gln Ala Leu Pro Pro Arg 
            260                 


<210> 562
<211> 308
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 562
Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        195                 200                 205             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    210                 215                 220                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
225                 230                 235                 240 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                245                 250                 255     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            260                 265                 270         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        275                 280                 285             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    290                 295                 300                 


Leu Pro Pro Arg 
305             


<210> 563
<211> 283
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 563
Gln Val Thr Asp Ile Asn Ser Lys Gly Leu Glu Leu Arg Lys Thr Val 
1               5                   10                  15      


Thr Thr Val Glu Thr Gln Asn Leu Glu Gly Leu His His Asp Gly Gln 
            20                  25                  30          


Phe Cys His Lys Pro Cys Pro Pro Gly Glu Arg Lys Ala Arg Asp Cys 
        35                  40                  45              


Thr Val Asn Gly Asp Glu Pro Asp Cys Val Pro Cys Gln Glu Gly Lys 
    50                  55                  60                  


Glu Tyr Thr Asp Lys Ala His Phe Ser Ser Lys Cys Arg Arg Cys Arg 
65                  70                  75                  80  


Leu Cys Asp Glu Gly His Gly Leu Glu Val Glu Ile Asn Cys Thr Arg 
                85                  90                  95      


Thr Gln Asn Thr Lys Cys Arg Cys Lys Pro Asn Phe Phe Cys Asn Ser 
            100                 105                 110         


Thr Val Cys Glu His Cys Asp Pro Cys Thr Lys Cys Glu His Gly Ile 
        115                 120                 125             


Ile Lys Glu Cys Thr Leu Thr Ser Asn Thr Lys Cys Lys Glu Glu Gly 
    130                 135                 140                 


Ser Arg Ser Asn Leu Gly Trp Leu Cys Leu Leu Leu Leu Pro Ile Pro 
145                 150                 155                 160 


Leu Ile Val Trp Val Lys Arg Lys Glu Val Gln Arg Val Lys Phe Ser 
                165                 170                 175     


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
            180                 185                 190         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        195                 200                 205             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    210                 215                 220                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
225                 230                 235                 240 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                245                 250                 255     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            260                 265                 270         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        275                 280             


<210> 564
<211> 375
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 564
Met Leu Pro Cys Leu Val Val Leu Leu Ala Ala Leu Leu Ser Leu Arg 
1               5                   10                  15      


Leu Gly Ser Asp Ala His Gly Thr Glu Leu Pro Ser Pro Pro Ser Val 
            20                  25                  30          


Trp Phe Glu Ala Glu Phe Phe His His Ile Leu His Trp Thr Pro Ile 
        35                  40                  45              


Pro Asn Gln Ser Glu Ser Thr Cys Tyr Glu Val Ala Leu Leu Arg Tyr 
    50                  55                  60                  


Gly Ile Glu Ser Trp Asn Ser Ile Ser Asn Cys Ser Gln Thr Leu Ser 
65                  70                  75                  80  


Tyr Asp Leu Thr Ala Val Thr Leu Asp Leu Tyr His Ser Asn Gly Tyr 
                85                  90                  95      


Arg Ala Arg Val Arg Ala Val Asp Gly Ser Arg His Ser Asn Trp Thr 
            100                 105                 110         


Val Thr Asn Thr Arg Phe Ser Val Asp Glu Val Thr Leu Thr Val Gly 
        115                 120                 125             


Ser Val Asn Leu Glu Ile His Asn Gly Phe Ile Leu Gly Lys Ile Gln 
    130                 135                 140                 


Leu Pro Arg Pro Lys Met Ala Pro Ala Asn Asp Thr Tyr Glu Ser Ile 
145                 150                 155                 160 


Phe Ser His Phe Arg Glu Tyr Glu Ile Ala Ile Arg Lys Val Pro Gly 
                165                 170                 175     


Asn Phe Thr Phe Thr His Lys Lys Val Lys His Glu Asn Phe Ser Leu 
            180                 185                 190         


Leu Thr Ser Gly Glu Val Gly Glu Phe Cys Val Gln Val Lys Pro Ser 
        195                 200                 205             


Val Ala Ser Arg Ser Asn Lys Gly Met Trp Ser Lys Glu Glu Cys Ile 
    210                 215                 220                 


Ser Leu Thr Arg Gln Tyr Phe Thr Val Thr Asn Val Ile Ile Phe Phe 
225                 230                 235                 240 


Ala Phe Val Leu Leu Leu Ser Gly Ala Leu Ala Tyr Cys Leu Ala Leu 
                245                 250                 255     


Gln Leu Tyr Val Arg Arg Arg Arg Val Lys Phe Ser Arg Ser Ala Asp 
            260                 265                 270         


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        275                 280                 285             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    290                 295                 300                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
305                 310                 315                 320 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                325                 330                 335     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            340                 345                 350         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        355                 360                 365             


Met Gln Ala Leu Pro Pro Arg 
    370                 375 


<210> 565
<211> 354
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 565
His Gly Thr Glu Leu Pro Ser Pro Pro Ser Val Trp Phe Glu Ala Glu 
1               5                   10                  15      


Phe Phe His His Ile Leu His Trp Thr Pro Ile Pro Asn Gln Ser Glu 
            20                  25                  30          


Ser Thr Cys Tyr Glu Val Ala Leu Leu Arg Tyr Gly Ile Glu Ser Trp 
        35                  40                  45              


Asn Ser Ile Ser Asn Cys Ser Gln Thr Leu Ser Tyr Asp Leu Thr Ala 
    50                  55                  60                  


Val Thr Leu Asp Leu Tyr His Ser Asn Gly Tyr Arg Ala Arg Val Arg 
65                  70                  75                  80  


Ala Val Asp Gly Ser Arg His Ser Asn Trp Thr Val Thr Asn Thr Arg 
                85                  90                  95      


Phe Ser Val Asp Glu Val Thr Leu Thr Val Gly Ser Val Asn Leu Glu 
            100                 105                 110         


Ile His Asn Gly Phe Ile Leu Gly Lys Ile Gln Leu Pro Arg Pro Lys 
        115                 120                 125             


Met Ala Pro Ala Asn Asp Thr Tyr Glu Ser Ile Phe Ser His Phe Arg 
    130                 135                 140                 


Glu Tyr Glu Ile Ala Ile Arg Lys Val Pro Gly Asn Phe Thr Phe Thr 
145                 150                 155                 160 


His Lys Lys Val Lys His Glu Asn Phe Ser Leu Leu Thr Ser Gly Glu 
                165                 170                 175     


Val Gly Glu Phe Cys Val Gln Val Lys Pro Ser Val Ala Ser Arg Ser 
            180                 185                 190         


Asn Lys Gly Met Trp Ser Lys Glu Glu Cys Ile Ser Leu Thr Arg Gln 
        195                 200                 205             


Tyr Phe Thr Val Thr Asn Val Ile Ile Phe Phe Ala Phe Val Leu Leu 
    210                 215                 220                 


Leu Ser Gly Ala Leu Ala Tyr Cys Leu Ala Leu Gln Leu Tyr Val Arg 
225                 230                 235                 240 


Arg Arg Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
                245                 250                 255     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            260                 265                 270         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        275                 280                 285             


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    290                 295                 300                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
305                 310                 315                 320 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                325                 330                 335     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            340                 345                 350         


Pro Arg 
        


<210> 566
<211> 361
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 566
Met Ala Trp Ser Leu Gly Ser Trp Leu Gly Gly Cys Leu Leu Val Ser 
1               5                   10                  15      


Ala Leu Gly Met Val Pro Pro Pro Glu Asn Val Arg Met Asn Ser Val 
            20                  25                  30          


Asn Phe Lys Asn Ile Leu Gln Trp Glu Ser Pro Ala Phe Ala Lys Gly 
        35                  40                  45              


Asn Leu Thr Phe Thr Ala Gln Tyr Leu Ser Tyr Arg Ile Phe Gln Asp 
    50                  55                  60                  


Lys Cys Met Asn Thr Thr Leu Thr Glu Cys Asp Phe Ser Ser Leu Ser 
65                  70                  75                  80  


Lys Tyr Gly Asp His Thr Leu Arg Val Arg Ala Glu Phe Ala Asp Glu 
                85                  90                  95      


His Ser Asp Trp Val Asn Ile Thr Phe Cys Pro Val Asp Asp Thr Ile 
            100                 105                 110         


Ile Gly Pro Pro Gly Met Gln Val Glu Val Leu Ala Asp Ser Leu His 
        115                 120                 125             


Met Arg Phe Leu Ala Pro Lys Ile Glu Asn Glu Tyr Glu Thr Trp Thr 
    130                 135                 140                 


Met Lys Asn Val Tyr Asn Ser Trp Thr Tyr Asn Val Gln Tyr Trp Lys 
145                 150                 155                 160 


Asn Gly Thr Asp Glu Lys Phe Gln Ile Thr Pro Gln Tyr Asp Phe Glu 
                165                 170                 175     


Val Leu Arg Asn Leu Glu Pro Trp Thr Thr Tyr Cys Val Gln Val Arg 
            180                 185                 190         


Gly Phe Leu Pro Asp Arg Asn Lys Ala Gly Glu Trp Ser Glu Pro Val 
        195                 200                 205             


Cys Glu Gln Thr Thr His Asp Glu Thr Val Pro Ser Trp Met Val Ala 
    210                 215                 220                 


Val Ile Leu Met Ala Ser Val Phe Met Val Cys Leu Ala Leu Leu Gly 
225                 230                 235                 240 


Cys Phe Ala Leu Leu Trp Cys Val Tyr Arg Val Lys Phe Ser Arg Ser 
                245                 250                 255     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            260                 265                 270         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        275                 280                 285             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    290                 295                 300                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
305                 310                 315                 320 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                325                 330                 335     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            340                 345                 350         


Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360     


<210> 567
<211> 342
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 567
Met Val Pro Pro Pro Glu Asn Val Arg Met Asn Ser Val Asn Phe Lys 
1               5                   10                  15      


Asn Ile Leu Gln Trp Glu Ser Pro Ala Phe Ala Lys Gly Asn Leu Thr 
            20                  25                  30          


Phe Thr Ala Gln Tyr Leu Ser Tyr Arg Ile Phe Gln Asp Lys Cys Met 
        35                  40                  45              


Asn Thr Thr Leu Thr Glu Cys Asp Phe Ser Ser Leu Ser Lys Tyr Gly 
    50                  55                  60                  


Asp His Thr Leu Arg Val Arg Ala Glu Phe Ala Asp Glu His Ser Asp 
65                  70                  75                  80  


Trp Val Asn Ile Thr Phe Cys Pro Val Asp Asp Thr Ile Ile Gly Pro 
                85                  90                  95      


Pro Gly Met Gln Val Glu Val Leu Ala Asp Ser Leu His Met Arg Phe 
            100                 105                 110         


Leu Ala Pro Lys Ile Glu Asn Glu Tyr Glu Thr Trp Thr Met Lys Asn 
        115                 120                 125             


Val Tyr Asn Ser Trp Thr Tyr Asn Val Gln Tyr Trp Lys Asn Gly Thr 
    130                 135                 140                 


Asp Glu Lys Phe Gln Ile Thr Pro Gln Tyr Asp Phe Glu Val Leu Arg 
145                 150                 155                 160 


Asn Leu Glu Pro Trp Thr Thr Tyr Cys Val Gln Val Arg Gly Phe Leu 
                165                 170                 175     


Pro Asp Arg Asn Lys Ala Gly Glu Trp Ser Glu Pro Val Cys Glu Gln 
            180                 185                 190         


Thr Thr His Asp Glu Thr Val Pro Ser Trp Met Val Ala Val Ile Leu 
        195                 200                 205             


Met Ala Ser Val Phe Met Val Cys Leu Ala Leu Leu Gly Cys Phe Ala 
    210                 215                 220                 


Leu Leu Trp Cys Val Tyr Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
225                 230                 235                 240 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                245                 250                 255     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            260                 265                 270         


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
        275                 280                 285             


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
    290                 295                 300                 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
305                 310                 315                 320 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                325                 330                 335     


Gln Ala Leu Pro Pro Arg 
            340         


<210> 568
<211> 759
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 568
Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Arg Val Lys Phe Ser Arg Ser Ala Asp 
                645                 650                 655     


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
            660                 665                 670         


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
        675                 680                 685             


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
    690                 695                 700                 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
705                 710                 715                 720 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
                725                 730                 735     


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
            740                 745                 750         


Met Gln Ala Leu Pro Pro Arg 
        755                 


<210> 569
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 569
Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser Pro Glu Ser Pro Val Val 
1               5                   10                  15      


Gln Leu His Ser Asn Phe Thr Ala Val Cys Val Leu Lys Glu Lys Cys 
            20                  25                  30          


Met Asp Tyr Phe His Val Asn Ala Asn Tyr Ile Val Trp Lys Thr Asn 
        35                  40                  45              


His Phe Thr Ile Pro Lys Glu Gln Tyr Thr Ile Ile Asn Arg Thr Ala 
    50                  55                  60                  


Ser Ser Val Thr Phe Thr Asp Ile Ala Ser Leu Asn Ile Gln Leu Thr 
65                  70                  75                  80  


Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu Gln Asn Val Tyr Gly Ile 
                85                  90                  95      


Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys Pro Lys Asn Leu Ser Cys 
            100                 105                 110         


Ile Val Asn Glu Gly Lys Lys Met Arg Cys Glu Trp Asp Gly Gly Arg 
        115                 120                 125             


Glu Thr His Leu Glu Thr Asn Phe Thr Leu Lys Ser Glu Trp Ala Thr 
    130                 135                 140                 


His Lys Phe Ala Asp Cys Lys Ala Lys Arg Asp Thr Pro Thr Ser Cys 
145                 150                 155                 160 


Thr Val Asp Tyr Ser Thr Val Tyr Phe Val Asn Ile Glu Val Trp Val 
                165                 170                 175     


Glu Ala Glu Asn Ala Leu Gly Lys Val Thr Ser Asp His Ile Asn Phe 
            180                 185                 190         


Asp Pro Val Tyr Lys Val Lys Pro Asn Pro Pro His Asn Leu Ser Val 
        195                 200                 205             


Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr Asn 
    210                 215                 220                 


Pro Ser Ile Lys Ser Val Ile Ile Leu Lys Tyr Asn Ile Gln Tyr Arg 
225                 230                 235                 240 


Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr Ala 
                245                 250                 255     


Ser Thr Arg Ser Ser Phe Thr Val Gln Asp Leu Lys Pro Phe Thr Glu 
            260                 265                 270         


Tyr Val Phe Arg Ile Arg Cys Met Lys Glu Asp Gly Lys Gly Tyr Trp 
        275                 280                 285             


Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile Thr Tyr Glu Asp Arg Pro 
    290                 295                 300                 


Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile Asp Pro Ser His Thr Gln 
305                 310                 315                 320 


Gly Tyr Arg Thr Val Gln Leu Val Trp Lys Thr Leu Pro Pro Phe Glu 
                325                 330                 335     


Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val Thr Leu Thr Arg Trp Lys 
            340                 345                 350         


Ser His Leu Gln Asn Tyr Thr Val Asn Ala Thr Lys Leu Thr Val Asn 
        355                 360                 365             


Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu Thr Val Arg Asn Leu Val 
    370                 375                 380                 


Gly Lys Ser Asp Ala Ala Val Leu Thr Ile Pro Ala Cys Asp Phe Gln 
385                 390                 395                 400 


Ala Thr His Pro Val Met Asp Leu Lys Ala Phe Pro Lys Asp Asn Met 
                405                 410                 415     


Leu Trp Val Glu Trp Thr Thr Pro Arg Glu Ser Val Lys Lys Tyr Ile 
            420                 425                 430         


Leu Glu Trp Cys Val Leu Ser Asp Lys Ala Pro Cys Ile Thr Asp Trp 
        435                 440                 445             


Gln Gln Glu Asp Gly Thr Val His Arg Thr Tyr Leu Arg Gly Asn Leu 
    450                 455                 460                 


Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val Thr Pro Val Tyr Ala Asp 
465                 470                 475                 480 


Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala Tyr Leu Lys Gln Ala Pro 
                485                 490                 495     


Pro Ser Lys Gly Pro Thr Val Arg Thr Lys Lys Val Gly Lys Asn Glu 
            500                 505                 510         


Ala Val Leu Glu Trp Asp Gln Leu Pro Val Asp Val Gln Asn Gly Phe 
        515                 520                 525             


Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr Ile Ile Gly Asn Glu Thr 
    530                 535                 540                 


Ala Val Asn Val Asp Ser Ser His Thr Glu Tyr Thr Leu Ser Ser Leu 
545                 550                 555                 560 


Thr Ser Asp Thr Leu Tyr Met Val Arg Met Ala Ala Tyr Thr Asp Glu 
                565                 570                 575     


Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe Thr Thr Pro Lys Phe Ala 
            580                 585                 590         


Gln Gly Glu Ile Glu Ala Ile Val Val Pro Val Cys Leu Ala Phe Leu 
        595                 600                 605             


Leu Thr Thr Leu Leu Gly Val Leu Phe Cys Phe Asn Lys Arg Asp Leu 
    610                 615                 620                 


Ile Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
625                 630                 635                 640 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                645                 650                 655     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            660                 665                 670         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        675                 680                 685             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    690                 695                 700                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
705                 710                 715                 720 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                725                 730                 735     


Arg 
    


<210> 570
<211> 334
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 570
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Met Gln Ile Pro Gln Ala Pro Trp Pro 
            20                  25                  30          


Val Val Trp Ala Val Leu Gln Leu Gly Trp Arg Pro Gly Trp Phe Leu 
        35                  40                  45              


Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
    50                  55                  60                  


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
65                  70                  75                  80  


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
                85                  90                  95      


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
            100                 105                 110         


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
        115                 120                 125             


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
    130                 135                 140                 


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
145                 150                 155                 160 


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
                165                 170                 175     


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu 
            180                 185                 190         


Val Val Val Gly Val Val Gly Gly Leu Leu Gly Ser Leu Val Leu Leu 
        195                 200                 205             


Val Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala Arg Gly Arg Val 
    210                 215                 220                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
225                 230                 235                 240 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                245                 250                 255     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            260                 265                 270         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        275                 280                 285             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    290                 295                 300                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
305                 310                 315                 320 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                325                 330                 


<210> 571
<211> 311
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 571
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Val Gly Val Val Gly 
                165                 170                 175     


Gly Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile 
            180                 185                 190         


Cys Ser Arg Ala Ala Arg Gly Arg Val Lys Phe Ser Arg Ser Ala Asp 
        195                 200                 205             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    210                 215                 220                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
225                 230                 235                 240 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                245                 250                 255     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            260                 265                 270         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        275                 280                 285             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    290                 295                 300                 


Met Gln Ala Leu Pro Pro Arg 
305                 310     


<210> 572
<211> 657
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 572
Met Glu Lys Lys Trp Lys Tyr Cys Ala Val Tyr Tyr Ile Ile Gln Ile 
1               5                   10                  15      


His Phe Val Lys Gly Val Trp Glu Lys Thr Val Asn Thr Glu Glu Asn 
            20                  25                  30          


Val Tyr Ala Thr Leu Gly Ser Asp Val Asn Leu Thr Cys Gln Thr Gln 
        35                  40                  45              


Thr Val Gly Phe Phe Val Gln Met Gln Trp Ser Lys Val Thr Asn Lys 
    50                  55                  60                  


Ile Asp Leu Ile Ala Val Tyr His Pro Gln Tyr Gly Phe Tyr Cys Ala 
65                  70                  75                  80  


Tyr Gly Arg Pro Cys Glu Ser Leu Val Thr Phe Thr Glu Thr Pro Glu 
                85                  90                  95      


Asn Gly Ser Lys Trp Thr Leu His Leu Arg Asn Met Ser Cys Ser Val 
            100                 105                 110         


Ser Gly Arg Tyr Glu Cys Met Leu Val Leu Tyr Pro Glu Gly Ile Gln 
        115                 120                 125             


Thr Lys Ile Tyr Asn Leu Leu Ile Gln Thr His Val Thr Ala Asp Glu 
    130                 135                 140                 


Trp Asn Ser Asn His Thr Ile Glu Ile Glu Ile Asn Gln Thr Leu Glu 
145                 150                 155                 160 


Ile Pro Cys Phe Gln Asn Ser Ser Ser Lys Ile Ser Ser Glu Phe Thr 
                165                 170                 175     


Tyr Ala Trp Ser Val Glu Asn Ser Ser Thr Asp Ser Trp Val Leu Leu 
            180                 185                 190         


Ser Lys Gly Ile Lys Glu Asp Asn Gly Thr Gln Glu Thr Leu Ile Ser 
        195                 200                 205             


Gln Asn His Leu Ile Ser Asn Ser Thr Leu Leu Lys Asp Arg Val Lys 
    210                 215                 220                 


Leu Gly Thr Asp Tyr Arg Leu His Leu Ser Pro Val Gln Ile Phe Asp 
225                 230                 235                 240 


Asp Gly Arg Lys Phe Ser Cys His Ile Arg Val Gly Pro Asn Lys Ile 
                245                 250                 255     


Leu Arg Ser Ser Thr Thr Val Lys Val Phe Ala Lys Pro Glu Ile Pro 
            260                 265                 270         


Val Ile Val Glu Asn Asn Ser Thr Asp Val Leu Val Glu Arg Arg Phe 
        275                 280                 285             


Thr Cys Leu Leu Lys Asn Val Phe Pro Lys Ala Asn Ile Thr Trp Phe 
    290                 295                 300                 


Ile Asp Gly Ser Phe Leu His Asp Glu Lys Glu Gly Ile Tyr Ile Thr 
305                 310                 315                 320 


Asn Glu Glu Arg Lys Gly Lys Asp Gly Phe Leu Glu Leu Lys Ser Val 
                325                 330                 335     


Leu Thr Arg Val His Ser Asn Lys Pro Ala Gln Ser Asp Asn Leu Thr 
            340                 345                 350         


Ile Trp Cys Met Ala Leu Ser Pro Val Pro Gly Asn Lys Val Trp Asn 
        355                 360                 365             


Ile Ser Ser Glu Lys Ile Thr Phe Leu Leu Gly Ser Glu Ile Ser Ser 
    370                 375                 380                 


Thr Asp Pro Pro Leu Ser Val Thr Glu Ser Thr Leu Asp Thr Gln Pro 
385                 390                 395                 400 


Ser Pro Ala Ser Ser Val Ser Pro Ala Arg Tyr Pro Ala Thr Ser Ser 
                405                 410                 415     


Val Thr Leu Val Asp Val Ser Ala Leu Arg Pro Asn Thr Thr Pro Gln 
            420                 425                 430         


Pro Ser Asn Ser Ser Met Thr Thr Arg Gly Phe Asn Tyr Pro Trp Thr 
        435                 440                 445             


Ser Ser Gly Thr Asp Thr Lys Lys Ser Val Ser Arg Ile Pro Ser Glu 
    450                 455                 460                 


Thr Tyr Ser Ser Ser Pro Ser Gly Ala Gly Ser Thr Leu His Asp Asn 
465                 470                 475                 480 


Val Phe Thr Ser Thr Ala Arg Ala Phe Ser Glu Val Pro Thr Thr Ala 
                485                 490                 495     


Asn Gly Ser Thr Lys Thr Asn His Val His Ile Thr Gly Ile Val Val 
            500                 505                 510         


Asn Lys Pro Lys Asp Gly Met Ser Trp Pro Val Ile Val Ala Ala Leu 
        515                 520                 525             


Leu Phe Cys Cys Met Ile Leu Phe Gly Leu Gly Val Arg Lys Trp Cys 
    530                 535                 540                 


Gln Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
545                 550                 555                 560 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                565                 570                 575     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            580                 585                 590         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        595                 600                 605             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    610                 615                 620                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
625                 630                 635                 640 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                645                 650                 655     


Arg 
    


<210> 573
<211> 636
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 573
Val Trp Glu Lys Thr Val Asn Thr Glu Glu Asn Val Tyr Ala Thr Leu 
1               5                   10                  15      


Gly Ser Asp Val Asn Leu Thr Cys Gln Thr Gln Thr Val Gly Phe Phe 
            20                  25                  30          


Val Gln Met Gln Trp Ser Lys Val Thr Asn Lys Ile Asp Leu Ile Ala 
        35                  40                  45              


Val Tyr His Pro Gln Tyr Gly Phe Tyr Cys Ala Tyr Gly Arg Pro Cys 
    50                  55                  60                  


Glu Ser Leu Val Thr Phe Thr Glu Thr Pro Glu Asn Gly Ser Lys Trp 
65                  70                  75                  80  


Thr Leu His Leu Arg Asn Met Ser Cys Ser Val Ser Gly Arg Tyr Glu 
                85                  90                  95      


Cys Met Leu Val Leu Tyr Pro Glu Gly Ile Gln Thr Lys Ile Tyr Asn 
            100                 105                 110         


Leu Leu Ile Gln Thr His Val Thr Ala Asp Glu Trp Asn Ser Asn His 
        115                 120                 125             


Thr Ile Glu Ile Glu Ile Asn Gln Thr Leu Glu Ile Pro Cys Phe Gln 
    130                 135                 140                 


Asn Ser Ser Ser Lys Ile Ser Ser Glu Phe Thr Tyr Ala Trp Ser Val 
145                 150                 155                 160 


Glu Asn Ser Ser Thr Asp Ser Trp Val Leu Leu Ser Lys Gly Ile Lys 
                165                 170                 175     


Glu Asp Asn Gly Thr Gln Glu Thr Leu Ile Ser Gln Asn His Leu Ile 
            180                 185                 190         


Ser Asn Ser Thr Leu Leu Lys Asp Arg Val Lys Leu Gly Thr Asp Tyr 
        195                 200                 205             


Arg Leu His Leu Ser Pro Val Gln Ile Phe Asp Asp Gly Arg Lys Phe 
    210                 215                 220                 


Ser Cys His Ile Arg Val Gly Pro Asn Lys Ile Leu Arg Ser Ser Thr 
225                 230                 235                 240 


Thr Val Lys Val Phe Ala Lys Pro Glu Ile Pro Val Ile Val Glu Asn 
                245                 250                 255     


Asn Ser Thr Asp Val Leu Val Glu Arg Arg Phe Thr Cys Leu Leu Lys 
            260                 265                 270         


Asn Val Phe Pro Lys Ala Asn Ile Thr Trp Phe Ile Asp Gly Ser Phe 
        275                 280                 285             


Leu His Asp Glu Lys Glu Gly Ile Tyr Ile Thr Asn Glu Glu Arg Lys 
    290                 295                 300                 


Gly Lys Asp Gly Phe Leu Glu Leu Lys Ser Val Leu Thr Arg Val His 
305                 310                 315                 320 


Ser Asn Lys Pro Ala Gln Ser Asp Asn Leu Thr Ile Trp Cys Met Ala 
                325                 330                 335     


Leu Ser Pro Val Pro Gly Asn Lys Val Trp Asn Ile Ser Ser Glu Lys 
            340                 345                 350         


Ile Thr Phe Leu Leu Gly Ser Glu Ile Ser Ser Thr Asp Pro Pro Leu 
        355                 360                 365             


Ser Val Thr Glu Ser Thr Leu Asp Thr Gln Pro Ser Pro Ala Ser Ser 
    370                 375                 380                 


Val Ser Pro Ala Arg Tyr Pro Ala Thr Ser Ser Val Thr Leu Val Asp 
385                 390                 395                 400 


Val Ser Ala Leu Arg Pro Asn Thr Thr Pro Gln Pro Ser Asn Ser Ser 
                405                 410                 415     


Met Thr Thr Arg Gly Phe Asn Tyr Pro Trp Thr Ser Ser Gly Thr Asp 
            420                 425                 430         


Thr Lys Lys Ser Val Ser Arg Ile Pro Ser Glu Thr Tyr Ser Ser Ser 
        435                 440                 445             


Pro Ser Gly Ala Gly Ser Thr Leu His Asp Asn Val Phe Thr Ser Thr 
    450                 455                 460                 


Ala Arg Ala Phe Ser Glu Val Pro Thr Thr Ala Asn Gly Ser Thr Lys 
465                 470                 475                 480 


Thr Asn His Val His Ile Thr Gly Ile Val Val Asn Lys Pro Lys Asp 
                485                 490                 495     


Gly Met Ser Trp Pro Val Ile Val Ala Ala Leu Leu Phe Cys Cys Met 
            500                 505                 510         


Ile Leu Phe Gly Leu Gly Val Arg Lys Trp Cys Gln Arg Val Lys Phe 
        515                 520                 525             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
    530                 535                 540                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
545                 550                 555                 560 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
                565                 570                 575     


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
            580                 585                 590         


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
        595                 600                 605             


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
    610                 615                 620                 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
625                 630                 635     


<210> 574
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 574
Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly 
    130                 135                 140                 


Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val 
145                 150                 155                 160 


Val Ala Leu Thr Arg Lys Lys Lys Ala Arg Val Lys Phe Ser Arg Ser 
                165                 170                 175     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            180                 185                 190         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        195                 200                 205             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    210                 215                 220                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
225                 230                 235                 240 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                245                 250                 255     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            260                 265                 270         


Leu His Met Gln Ala Leu Pro Pro Arg 
        275                 280     


<210> 575
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 575
Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
1               5                   10                  15      


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
            20                  25                  30          


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
        35                  40                  45              


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
    50                  55                  60                  


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
65                  70                  75                  80  


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr 
                85                  90                  95      


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
            100                 105                 110         


His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly Ala Met Ala Ala Thr 
        115                 120                 125             


Leu Val Val Ile Cys Thr Ala Val Ile Val Val Val Ala Leu Thr Arg 
    130                 135                 140                 


Lys Lys Lys Ala Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
145                 150                 155                 160 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                165                 170                 175     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            180                 185                 190         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        195                 200                 205             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    210                 215                 220                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
225                 230                 235                 240 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                245                 250                 255     


Leu Pro Pro Arg 
            260 


<210> 576
<211> 296
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 576
Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              


Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg Pro Ser 
    130                 135                 140                 


Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Phe Trp Val 
145                 150                 155                 160 


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
                165                 170                 175     


Val Ala Phe Ile Ile Phe Trp Val Arg Val Lys Phe Ser Arg Ser Ala 
            180                 185                 190         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        195                 200                 205             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    210                 215                 220                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
225                 230                 235                 240 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                245                 250                 255     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            260                 265                 270         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        275                 280                 285             


His Met Gln Ala Leu Pro Pro Arg 
    290                 295     


<210> 577
<211> 266
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 577
Lys Glu Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His 
1               5                   10                  15      


Ser Ile Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr 
            20                  25                  30          


Cys Ala Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr 
        35                  40                  45              


Cys Val Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn 
    50                  55                  60                  


Ile Ser Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn 
65                  70                  75                  80  


Gly Ser Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser 
                85                  90                  95      


His Ser Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg 
            100                 105                 110         


Pro Ser Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Phe 
        115                 120                 125             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    130                 135                 140                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Val Lys Phe Ser Arg 
145                 150                 155                 160 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                165                 170                 175     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            180                 185                 190         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        195                 200                 205             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    210                 215                 220                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
225                 230                 235                 240 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                245                 250                 255     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            260                 265     


<210> 578
<211> 382
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 578
Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Ala Ser Ser Ser Leu Cys Met Asp Glu Lys 
            20                  25                  30          


Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu Val Asn Thr Ser 
        35                  40                  45              


Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys Cys Pro Pro Ile 
    50                  55                  60                  


Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile Ile Leu Arg Gly 
65                  70                  75                  80  


Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys Glu Thr Asn Glu Thr Lys 
                85                  90                  95      


Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val Ser Arg Pro Asp 
            100                 105                 110         


Gln Asn Ser Asp Leu Gln Ile Arg Pro Val Ala Ile Thr His Asp Gly 
        115                 120                 125             


Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn Phe His Arg Gly 
    130                 135                 140                 


Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr Leu Phe Gln Asn 
145                 150                 155                 160 


Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly Lys Pro Ala Ala 
                165                 170                 175     


Gln Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr Lys Gln Glu Tyr 
            180                 185                 190         


Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys His Trp Glu Val 
        195                 200                 205             


His Asn Val Ser Thr Val Thr Cys His Val Ser His Leu Thr Gly Asn 
    210                 215                 220                 


Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly Ala Lys Lys Ser 
225                 230                 235                 240 


Ala Lys Leu Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
                245                 250                 255     


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Val 
            260                 265                 270         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        275                 280                 285             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    290                 295                 300                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
305                 310                 315                 320 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                325                 330                 335     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            340                 345                 350         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        355                 360                 365             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    370                 375                 380         


<210> 579
<211> 354
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 579
Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu 
1               5                   10                  15      


Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys 
            20                  25                  30          


Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile 
        35                  40                  45              


Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys Glu Thr 
    50                  55                  60                  


Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val 
65                  70                  75                  80  


Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Pro Val Ala Ile 
                85                  90                  95      


Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn 
            100                 105                 110         


Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr 
        115                 120                 125             


Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly 
    130                 135                 140                 


Lys Pro Ala Ala Gln Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr 
145                 150                 155                 160 


Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys 
                165                 170                 175     


His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His Val Ser His 
            180                 185                 190         


Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly 
        195                 200                 205             


Ala Lys Lys Ser Ala Lys Leu Phe Trp Val Leu Val Val Val Gly Gly 
    210                 215                 220                 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
225                 230                 235                 240 


Trp Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
                245                 250                 255     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            260                 265                 270         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        275                 280                 285             


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    290                 295                 300                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
305                 310                 315                 320 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                325                 330                 335     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            340                 345                 350         


Pro Arg 
        


<210> 580
<211> 300
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 580
Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
                165                 170                 175     


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Val Lys Phe 
            180                 185                 190         


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        195                 200                 205             


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    210                 215                 220                 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
225                 230                 235                 240 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                245                 250                 255     


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            260                 265                 270         


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        275                 280                 285             


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    290                 295                 300 


<210> 581
<211> 265
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 581
Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Phe Trp 
        115                 120                 125             


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
    130                 135                 140                 


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Val Lys Phe Ser Arg Ser 
145                 150                 155                 160 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                165                 170                 175     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            180                 185                 190         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        195                 200                 205             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    210                 215                 220                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
225                 230                 235                 240 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                245                 250                 255     


Leu His Met Gln Ala Leu Pro Pro Arg 
            260                 265 


<210> 582
<211> 312
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 582
Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Phe Trp Val 
                165                 170                 175     


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
            180                 185                 190         


Val Ala Phe Ile Ile Phe Trp Val Arg Val Lys Phe Ser Arg Ser Ala 
        195                 200                 205             


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    210                 215                 220                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
225                 230                 235                 240 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                245                 250                 255     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            260                 265                 270         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        275                 280                 285             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    290                 295                 300                 


His Met Gln Ala Leu Pro Pro Arg 
305                 310         


<210> 583
<211> 287
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 583
Gln Val Thr Asp Ile Asn Ser Lys Gly Leu Glu Leu Arg Lys Thr Val 
1               5                   10                  15      


Thr Thr Val Glu Thr Gln Asn Leu Glu Gly Leu His His Asp Gly Gln 
            20                  25                  30          


Phe Cys His Lys Pro Cys Pro Pro Gly Glu Arg Lys Ala Arg Asp Cys 
        35                  40                  45              


Thr Val Asn Gly Asp Glu Pro Asp Cys Val Pro Cys Gln Glu Gly Lys 
    50                  55                  60                  


Glu Tyr Thr Asp Lys Ala His Phe Ser Ser Lys Cys Arg Arg Cys Arg 
65                  70                  75                  80  


Leu Cys Asp Glu Gly His Gly Leu Glu Val Glu Ile Asn Cys Thr Arg 
                85                  90                  95      


Thr Gln Asn Thr Lys Cys Arg Cys Lys Pro Asn Phe Phe Cys Asn Ser 
            100                 105                 110         


Thr Val Cys Glu His Cys Asp Pro Cys Thr Lys Cys Glu His Gly Ile 
        115                 120                 125             


Ile Lys Glu Cys Thr Leu Thr Ser Asn Thr Lys Cys Lys Glu Glu Gly 
    130                 135                 140                 


Ser Arg Ser Asn Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
145                 150                 155                 160 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
                165                 170                 175     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            180                 185                 190         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        195                 200                 205             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    210                 215                 220                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
225                 230                 235                 240 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                245                 250                 255     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            260                 265                 270         


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        275                 280                 285         


<210> 584
<211> 374
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 584
Met Leu Pro Cys Leu Val Val Leu Leu Ala Ala Leu Leu Ser Leu Arg 
1               5                   10                  15      


Leu Gly Ser Asp Ala His Gly Thr Glu Leu Pro Ser Pro Pro Ser Val 
            20                  25                  30          


Trp Phe Glu Ala Glu Phe Phe His His Ile Leu His Trp Thr Pro Ile 
        35                  40                  45              


Pro Asn Gln Ser Glu Ser Thr Cys Tyr Glu Val Ala Leu Leu Arg Tyr 
    50                  55                  60                  


Gly Ile Glu Ser Trp Asn Ser Ile Ser Asn Cys Ser Gln Thr Leu Ser 
65                  70                  75                  80  


Tyr Asp Leu Thr Ala Val Thr Leu Asp Leu Tyr His Ser Asn Gly Tyr 
                85                  90                  95      


Arg Ala Arg Val Arg Ala Val Asp Gly Ser Arg His Ser Asn Trp Thr 
            100                 105                 110         


Val Thr Asn Thr Arg Phe Ser Val Asp Glu Val Thr Leu Thr Val Gly 
        115                 120                 125             


Ser Val Asn Leu Glu Ile His Asn Gly Phe Ile Leu Gly Lys Ile Gln 
    130                 135                 140                 


Leu Pro Arg Pro Lys Met Ala Pro Ala Asn Asp Thr Tyr Glu Ser Ile 
145                 150                 155                 160 


Phe Ser His Phe Arg Glu Tyr Glu Ile Ala Ile Arg Lys Val Pro Gly 
                165                 170                 175     


Asn Phe Thr Phe Thr His Lys Lys Val Lys His Glu Asn Phe Ser Leu 
            180                 185                 190         


Leu Thr Ser Gly Glu Val Gly Glu Phe Cys Val Gln Val Lys Pro Ser 
        195                 200                 205             


Val Ala Ser Arg Ser Asn Lys Gly Met Trp Ser Lys Glu Glu Cys Ile 
    210                 215                 220                 


Ser Leu Thr Arg Gln Tyr Phe Thr Val Thr Asn Phe Trp Val Leu Val 
225                 230                 235                 240 


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
                245                 250                 255     


Phe Ile Ile Phe Trp Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            260                 265                 270         


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        275                 280                 285             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    290                 295                 300                 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
305                 310                 315                 320 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
                325                 330                 335     


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
            340                 345                 350         


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
        355                 360                 365             


Gln Ala Leu Pro Pro Arg 
    370                 


<210> 585
<211> 353
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 585
His Gly Thr Glu Leu Pro Ser Pro Pro Ser Val Trp Phe Glu Ala Glu 
1               5                   10                  15      


Phe Phe His His Ile Leu His Trp Thr Pro Ile Pro Asn Gln Ser Glu 
            20                  25                  30          


Ser Thr Cys Tyr Glu Val Ala Leu Leu Arg Tyr Gly Ile Glu Ser Trp 
        35                  40                  45              


Asn Ser Ile Ser Asn Cys Ser Gln Thr Leu Ser Tyr Asp Leu Thr Ala 
    50                  55                  60                  


Val Thr Leu Asp Leu Tyr His Ser Asn Gly Tyr Arg Ala Arg Val Arg 
65                  70                  75                  80  


Ala Val Asp Gly Ser Arg His Ser Asn Trp Thr Val Thr Asn Thr Arg 
                85                  90                  95      


Phe Ser Val Asp Glu Val Thr Leu Thr Val Gly Ser Val Asn Leu Glu 
            100                 105                 110         


Ile His Asn Gly Phe Ile Leu Gly Lys Ile Gln Leu Pro Arg Pro Lys 
        115                 120                 125             


Met Ala Pro Ala Asn Asp Thr Tyr Glu Ser Ile Phe Ser His Phe Arg 
    130                 135                 140                 


Glu Tyr Glu Ile Ala Ile Arg Lys Val Pro Gly Asn Phe Thr Phe Thr 
145                 150                 155                 160 


His Lys Lys Val Lys His Glu Asn Phe Ser Leu Leu Thr Ser Gly Glu 
                165                 170                 175     


Val Gly Glu Phe Cys Val Gln Val Lys Pro Ser Val Ala Ser Arg Ser 
            180                 185                 190         


Asn Lys Gly Met Trp Ser Lys Glu Glu Cys Ile Ser Leu Thr Arg Gln 
        195                 200                 205             


Tyr Phe Thr Val Thr Asn Phe Trp Val Leu Val Val Val Gly Gly Val 
    210                 215                 220                 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
225                 230                 235                 240 


Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
                245                 250                 255     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            260                 265                 270         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        275                 280                 285             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    290                 295                 300                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
305                 310                 315                 320 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                325                 330                 335     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            340                 345                 350         


Arg 
    


<210> 586
<211> 359
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 586
Met Ala Trp Ser Leu Gly Ser Trp Leu Gly Gly Cys Leu Leu Val Ser 
1               5                   10                  15      


Ala Leu Gly Met Val Pro Pro Pro Glu Asn Val Arg Met Asn Ser Val 
            20                  25                  30          


Asn Phe Lys Asn Ile Leu Gln Trp Glu Ser Pro Ala Phe Ala Lys Gly 
        35                  40                  45              


Asn Leu Thr Phe Thr Ala Gln Tyr Leu Ser Tyr Arg Ile Phe Gln Asp 
    50                  55                  60                  


Lys Cys Met Asn Thr Thr Leu Thr Glu Cys Asp Phe Ser Ser Leu Ser 
65                  70                  75                  80  


Lys Tyr Gly Asp His Thr Leu Arg Val Arg Ala Glu Phe Ala Asp Glu 
                85                  90                  95      


His Ser Asp Trp Val Asn Ile Thr Phe Cys Pro Val Asp Asp Thr Ile 
            100                 105                 110         


Ile Gly Pro Pro Gly Met Gln Val Glu Val Leu Ala Asp Ser Leu His 
        115                 120                 125             


Met Arg Phe Leu Ala Pro Lys Ile Glu Asn Glu Tyr Glu Thr Trp Thr 
    130                 135                 140                 


Met Lys Asn Val Tyr Asn Ser Trp Thr Tyr Asn Val Gln Tyr Trp Lys 
145                 150                 155                 160 


Asn Gly Thr Asp Glu Lys Phe Gln Ile Thr Pro Gln Tyr Asp Phe Glu 
                165                 170                 175     


Val Leu Arg Asn Leu Glu Pro Trp Thr Thr Tyr Cys Val Gln Val Arg 
            180                 185                 190         


Gly Phe Leu Pro Asp Arg Asn Lys Ala Gly Glu Trp Ser Glu Pro Val 
        195                 200                 205             


Cys Glu Gln Thr Thr His Asp Glu Thr Val Pro Ser Phe Trp Val Leu 
    210                 215                 220                 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
225                 230                 235                 240 


Ala Phe Ile Ile Phe Trp Val Arg Val Lys Phe Ser Arg Ser Ala Asp 
                245                 250                 255     


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
            260                 265                 270         


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
        275                 280                 285             


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
    290                 295                 300                 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
305                 310                 315                 320 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
                325                 330                 335     


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
            340                 345                 350         


Met Gln Ala Leu Pro Pro Arg 
        355                 


<210> 587
<211> 340
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 587
Met Val Pro Pro Pro Glu Asn Val Arg Met Asn Ser Val Asn Phe Lys 
1               5                   10                  15      


Asn Ile Leu Gln Trp Glu Ser Pro Ala Phe Ala Lys Gly Asn Leu Thr 
            20                  25                  30          


Phe Thr Ala Gln Tyr Leu Ser Tyr Arg Ile Phe Gln Asp Lys Cys Met 
        35                  40                  45              


Asn Thr Thr Leu Thr Glu Cys Asp Phe Ser Ser Leu Ser Lys Tyr Gly 
    50                  55                  60                  


Asp His Thr Leu Arg Val Arg Ala Glu Phe Ala Asp Glu His Ser Asp 
65                  70                  75                  80  


Trp Val Asn Ile Thr Phe Cys Pro Val Asp Asp Thr Ile Ile Gly Pro 
                85                  90                  95      


Pro Gly Met Gln Val Glu Val Leu Ala Asp Ser Leu His Met Arg Phe 
            100                 105                 110         


Leu Ala Pro Lys Ile Glu Asn Glu Tyr Glu Thr Trp Thr Met Lys Asn 
        115                 120                 125             


Val Tyr Asn Ser Trp Thr Tyr Asn Val Gln Tyr Trp Lys Asn Gly Thr 
    130                 135                 140                 


Asp Glu Lys Phe Gln Ile Thr Pro Gln Tyr Asp Phe Glu Val Leu Arg 
145                 150                 155                 160 


Asn Leu Glu Pro Trp Thr Thr Tyr Cys Val Gln Val Arg Gly Phe Leu 
                165                 170                 175     


Pro Asp Arg Asn Lys Ala Gly Glu Trp Ser Glu Pro Val Cys Glu Gln 
            180                 185                 190         


Thr Thr His Asp Glu Thr Val Pro Ser Phe Trp Val Leu Val Val Val 
        195                 200                 205             


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
    210                 215                 220                 


Ile Phe Trp Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
225                 230                 235                 240 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                245                 250                 255     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            260                 265                 270         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        275                 280                 285             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    290                 295                 300                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
305                 310                 315                 320 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                325                 330                 335     


Leu Pro Pro Arg 
            340 


<210> 588
<211> 758
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 588
Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Phe Trp Val Leu Val 
    610                 615                 620                 


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
625                 630                 635                 640 


Phe Ile Ile Phe Trp Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                645                 650                 655     


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            660                 665                 670         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        675                 680                 685             


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
    690                 695                 700                 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
705                 710                 715                 720 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
                725                 730                 735     


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
            740                 745                 750         


Gln Ala Leu Pro Pro Arg 
        755             


<210> 589
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 589
Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser Pro Glu Ser Pro Val Val 
1               5                   10                  15      


Gln Leu His Ser Asn Phe Thr Ala Val Cys Val Leu Lys Glu Lys Cys 
            20                  25                  30          


Met Asp Tyr Phe His Val Asn Ala Asn Tyr Ile Val Trp Lys Thr Asn 
        35                  40                  45              


His Phe Thr Ile Pro Lys Glu Gln Tyr Thr Ile Ile Asn Arg Thr Ala 
    50                  55                  60                  


Ser Ser Val Thr Phe Thr Asp Ile Ala Ser Leu Asn Ile Gln Leu Thr 
65                  70                  75                  80  


Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu Gln Asn Val Tyr Gly Ile 
                85                  90                  95      


Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys Pro Lys Asn Leu Ser Cys 
            100                 105                 110         


Ile Val Asn Glu Gly Lys Lys Met Arg Cys Glu Trp Asp Gly Gly Arg 
        115                 120                 125             


Glu Thr His Leu Glu Thr Asn Phe Thr Leu Lys Ser Glu Trp Ala Thr 
    130                 135                 140                 


His Lys Phe Ala Asp Cys Lys Ala Lys Arg Asp Thr Pro Thr Ser Cys 
145                 150                 155                 160 


Thr Val Asp Tyr Ser Thr Val Tyr Phe Val Asn Ile Glu Val Trp Val 
                165                 170                 175     


Glu Ala Glu Asn Ala Leu Gly Lys Val Thr Ser Asp His Ile Asn Phe 
            180                 185                 190         


Asp Pro Val Tyr Lys Val Lys Pro Asn Pro Pro His Asn Leu Ser Val 
        195                 200                 205             


Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr Asn 
    210                 215                 220                 


Pro Ser Ile Lys Ser Val Ile Ile Leu Lys Tyr Asn Ile Gln Tyr Arg 
225                 230                 235                 240 


Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr Ala 
                245                 250                 255     


Ser Thr Arg Ser Ser Phe Thr Val Gln Asp Leu Lys Pro Phe Thr Glu 
            260                 265                 270         


Tyr Val Phe Arg Ile Arg Cys Met Lys Glu Asp Gly Lys Gly Tyr Trp 
        275                 280                 285             


Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile Thr Tyr Glu Asp Arg Pro 
    290                 295                 300                 


Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile Asp Pro Ser His Thr Gln 
305                 310                 315                 320 


Gly Tyr Arg Thr Val Gln Leu Val Trp Lys Thr Leu Pro Pro Phe Glu 
                325                 330                 335     


Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val Thr Leu Thr Arg Trp Lys 
            340                 345                 350         


Ser His Leu Gln Asn Tyr Thr Val Asn Ala Thr Lys Leu Thr Val Asn 
        355                 360                 365             


Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu Thr Val Arg Asn Leu Val 
    370                 375                 380                 


Gly Lys Ser Asp Ala Ala Val Leu Thr Ile Pro Ala Cys Asp Phe Gln 
385                 390                 395                 400 


Ala Thr His Pro Val Met Asp Leu Lys Ala Phe Pro Lys Asp Asn Met 
                405                 410                 415     


Leu Trp Val Glu Trp Thr Thr Pro Arg Glu Ser Val Lys Lys Tyr Ile 
            420                 425                 430         


Leu Glu Trp Cys Val Leu Ser Asp Lys Ala Pro Cys Ile Thr Asp Trp 
        435                 440                 445             


Gln Gln Glu Asp Gly Thr Val His Arg Thr Tyr Leu Arg Gly Asn Leu 
    450                 455                 460                 


Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val Thr Pro Val Tyr Ala Asp 
465                 470                 475                 480 


Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala Tyr Leu Lys Gln Ala Pro 
                485                 490                 495     


Pro Ser Lys Gly Pro Thr Val Arg Thr Lys Lys Val Gly Lys Asn Glu 
            500                 505                 510         


Ala Val Leu Glu Trp Asp Gln Leu Pro Val Asp Val Gln Asn Gly Phe 
        515                 520                 525             


Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr Ile Ile Gly Asn Glu Thr 
    530                 535                 540                 


Ala Val Asn Val Asp Ser Ser His Thr Glu Tyr Thr Leu Ser Ser Leu 
545                 550                 555                 560 


Thr Ser Asp Thr Leu Tyr Met Val Arg Met Ala Ala Tyr Thr Asp Glu 
                565                 570                 575     


Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe Thr Thr Pro Lys Phe Ala 
            580                 585                 590         


Gln Gly Glu Ile Glu Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
        595                 600                 605             


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
    610                 615                 620                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
625                 630                 635                 640 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                645                 650                 655     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            660                 665                 670         


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        675                 680                 685             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    690                 695                 700                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
705                 710                 715                 720 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730                 735     


<210> 590
<211> 333
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 590
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Met Gln Ile Pro Gln Ala Pro Trp Pro 
            20                  25                  30          


Val Val Trp Ala Val Leu Gln Leu Gly Trp Arg Pro Gly Trp Phe Leu 
        35                  40                  45              


Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
    50                  55                  60                  


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
65                  70                  75                  80  


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
                85                  90                  95      


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
            100                 105                 110         


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
        115                 120                 125             


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
    130                 135                 140                 


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
145                 150                 155                 160 


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr 
                165                 170                 175     


Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu 
            180                 185                 190         


Val Val Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
        195                 200                 205             


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Val Lys 
    210                 215                 220                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
225                 230                 235                 240 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                245                 250                 255     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            260                 265                 270         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        275                 280                 285             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    290                 295                 300                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
305                 310                 315                 320 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                325                 330             


<210> 591
<211> 310
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 591
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Phe Trp Val Leu Val 
                165                 170                 175     


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
            180                 185                 190         


Phe Ile Ile Phe Trp Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        195                 200                 205             


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    210                 215                 220                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
225                 230                 235                 240 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                245                 250                 255     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            260                 265                 270         


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
        275                 280                 285             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
    290                 295                 300                 


Gln Ala Leu Pro Pro Arg 
305                 310 


<210> 592
<211> 658
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 592
Met Glu Lys Lys Trp Lys Tyr Cys Ala Val Tyr Tyr Ile Ile Gln Ile 
1               5                   10                  15      


His Phe Val Lys Gly Val Trp Glu Lys Thr Val Asn Thr Glu Glu Asn 
            20                  25                  30          


Val Tyr Ala Thr Leu Gly Ser Asp Val Asn Leu Thr Cys Gln Thr Gln 
        35                  40                  45              


Thr Val Gly Phe Phe Val Gln Met Gln Trp Ser Lys Val Thr Asn Lys 
    50                  55                  60                  


Ile Asp Leu Ile Ala Val Tyr His Pro Gln Tyr Gly Phe Tyr Cys Ala 
65                  70                  75                  80  


Tyr Gly Arg Pro Cys Glu Ser Leu Val Thr Phe Thr Glu Thr Pro Glu 
                85                  90                  95      


Asn Gly Ser Lys Trp Thr Leu His Leu Arg Asn Met Ser Cys Ser Val 
            100                 105                 110         


Ser Gly Arg Tyr Glu Cys Met Leu Val Leu Tyr Pro Glu Gly Ile Gln 
        115                 120                 125             


Thr Lys Ile Tyr Asn Leu Leu Ile Gln Thr His Val Thr Ala Asp Glu 
    130                 135                 140                 


Trp Asn Ser Asn His Thr Ile Glu Ile Glu Ile Asn Gln Thr Leu Glu 
145                 150                 155                 160 


Ile Pro Cys Phe Gln Asn Ser Ser Ser Lys Ile Ser Ser Glu Phe Thr 
                165                 170                 175     


Tyr Ala Trp Ser Val Glu Asn Ser Ser Thr Asp Ser Trp Val Leu Leu 
            180                 185                 190         


Ser Lys Gly Ile Lys Glu Asp Asn Gly Thr Gln Glu Thr Leu Ile Ser 
        195                 200                 205             


Gln Asn His Leu Ile Ser Asn Ser Thr Leu Leu Lys Asp Arg Val Lys 
    210                 215                 220                 


Leu Gly Thr Asp Tyr Arg Leu His Leu Ser Pro Val Gln Ile Phe Asp 
225                 230                 235                 240 


Asp Gly Arg Lys Phe Ser Cys His Ile Arg Val Gly Pro Asn Lys Ile 
                245                 250                 255     


Leu Arg Ser Ser Thr Thr Val Lys Val Phe Ala Lys Pro Glu Ile Pro 
            260                 265                 270         


Val Ile Val Glu Asn Asn Ser Thr Asp Val Leu Val Glu Arg Arg Phe 
        275                 280                 285             


Thr Cys Leu Leu Lys Asn Val Phe Pro Lys Ala Asn Ile Thr Trp Phe 
    290                 295                 300                 


Ile Asp Gly Ser Phe Leu His Asp Glu Lys Glu Gly Ile Tyr Ile Thr 
305                 310                 315                 320 


Asn Glu Glu Arg Lys Gly Lys Asp Gly Phe Leu Glu Leu Lys Ser Val 
                325                 330                 335     


Leu Thr Arg Val His Ser Asn Lys Pro Ala Gln Ser Asp Asn Leu Thr 
            340                 345                 350         


Ile Trp Cys Met Ala Leu Ser Pro Val Pro Gly Asn Lys Val Trp Asn 
        355                 360                 365             


Ile Ser Ser Glu Lys Ile Thr Phe Leu Leu Gly Ser Glu Ile Ser Ser 
    370                 375                 380                 


Thr Asp Pro Pro Leu Ser Val Thr Glu Ser Thr Leu Asp Thr Gln Pro 
385                 390                 395                 400 


Ser Pro Ala Ser Ser Val Ser Pro Ala Arg Tyr Pro Ala Thr Ser Ser 
                405                 410                 415     


Val Thr Leu Val Asp Val Ser Ala Leu Arg Pro Asn Thr Thr Pro Gln 
            420                 425                 430         


Pro Ser Asn Ser Ser Met Thr Thr Arg Gly Phe Asn Tyr Pro Trp Thr 
        435                 440                 445             


Ser Ser Gly Thr Asp Thr Lys Lys Ser Val Ser Arg Ile Pro Ser Glu 
    450                 455                 460                 


Thr Tyr Ser Ser Ser Pro Ser Gly Ala Gly Ser Thr Leu His Asp Asn 
465                 470                 475                 480 


Val Phe Thr Ser Thr Ala Arg Ala Phe Ser Glu Val Pro Thr Thr Ala 
                485                 490                 495     


Asn Gly Ser Thr Lys Thr Asn His Val His Ile Thr Gly Ile Val Val 
            500                 505                 510         


Asn Lys Pro Lys Asp Gly Met Phe Trp Val Leu Val Val Val Gly Gly 
        515                 520                 525             


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    530                 535                 540                 


Trp Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
545                 550                 555                 560 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                565                 570                 575     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            580                 585                 590         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        595                 600                 605             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    610                 615                 620                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
625                 630                 635                 640 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                645                 650                 655     


Pro Arg 
        


<210> 593
<211> 637
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 593
Val Trp Glu Lys Thr Val Asn Thr Glu Glu Asn Val Tyr Ala Thr Leu 
1               5                   10                  15      


Gly Ser Asp Val Asn Leu Thr Cys Gln Thr Gln Thr Val Gly Phe Phe 
            20                  25                  30          


Val Gln Met Gln Trp Ser Lys Val Thr Asn Lys Ile Asp Leu Ile Ala 
        35                  40                  45              


Val Tyr His Pro Gln Tyr Gly Phe Tyr Cys Ala Tyr Gly Arg Pro Cys 
    50                  55                  60                  


Glu Ser Leu Val Thr Phe Thr Glu Thr Pro Glu Asn Gly Ser Lys Trp 
65                  70                  75                  80  


Thr Leu His Leu Arg Asn Met Ser Cys Ser Val Ser Gly Arg Tyr Glu 
                85                  90                  95      


Cys Met Leu Val Leu Tyr Pro Glu Gly Ile Gln Thr Lys Ile Tyr Asn 
            100                 105                 110         


Leu Leu Ile Gln Thr His Val Thr Ala Asp Glu Trp Asn Ser Asn His 
        115                 120                 125             


Thr Ile Glu Ile Glu Ile Asn Gln Thr Leu Glu Ile Pro Cys Phe Gln 
    130                 135                 140                 


Asn Ser Ser Ser Lys Ile Ser Ser Glu Phe Thr Tyr Ala Trp Ser Val 
145                 150                 155                 160 


Glu Asn Ser Ser Thr Asp Ser Trp Val Leu Leu Ser Lys Gly Ile Lys 
                165                 170                 175     


Glu Asp Asn Gly Thr Gln Glu Thr Leu Ile Ser Gln Asn His Leu Ile 
            180                 185                 190         


Ser Asn Ser Thr Leu Leu Lys Asp Arg Val Lys Leu Gly Thr Asp Tyr 
        195                 200                 205             


Arg Leu His Leu Ser Pro Val Gln Ile Phe Asp Asp Gly Arg Lys Phe 
    210                 215                 220                 


Ser Cys His Ile Arg Val Gly Pro Asn Lys Ile Leu Arg Ser Ser Thr 
225                 230                 235                 240 


Thr Val Lys Val Phe Ala Lys Pro Glu Ile Pro Val Ile Val Glu Asn 
                245                 250                 255     


Asn Ser Thr Asp Val Leu Val Glu Arg Arg Phe Thr Cys Leu Leu Lys 
            260                 265                 270         


Asn Val Phe Pro Lys Ala Asn Ile Thr Trp Phe Ile Asp Gly Ser Phe 
        275                 280                 285             


Leu His Asp Glu Lys Glu Gly Ile Tyr Ile Thr Asn Glu Glu Arg Lys 
    290                 295                 300                 


Gly Lys Asp Gly Phe Leu Glu Leu Lys Ser Val Leu Thr Arg Val His 
305                 310                 315                 320 


Ser Asn Lys Pro Ala Gln Ser Asp Asn Leu Thr Ile Trp Cys Met Ala 
                325                 330                 335     


Leu Ser Pro Val Pro Gly Asn Lys Val Trp Asn Ile Ser Ser Glu Lys 
            340                 345                 350         


Ile Thr Phe Leu Leu Gly Ser Glu Ile Ser Ser Thr Asp Pro Pro Leu 
        355                 360                 365             


Ser Val Thr Glu Ser Thr Leu Asp Thr Gln Pro Ser Pro Ala Ser Ser 
    370                 375                 380                 


Val Ser Pro Ala Arg Tyr Pro Ala Thr Ser Ser Val Thr Leu Val Asp 
385                 390                 395                 400 


Val Ser Ala Leu Arg Pro Asn Thr Thr Pro Gln Pro Ser Asn Ser Ser 
                405                 410                 415     


Met Thr Thr Arg Gly Phe Asn Tyr Pro Trp Thr Ser Ser Gly Thr Asp 
            420                 425                 430         


Thr Lys Lys Ser Val Ser Arg Ile Pro Ser Glu Thr Tyr Ser Ser Ser 
        435                 440                 445             


Pro Ser Gly Ala Gly Ser Thr Leu His Asp Asn Val Phe Thr Ser Thr 
    450                 455                 460                 


Ala Arg Ala Phe Ser Glu Val Pro Thr Thr Ala Asn Gly Ser Thr Lys 
465                 470                 475                 480 


Thr Asn His Val His Ile Thr Gly Ile Val Val Asn Lys Pro Lys Asp 
                485                 490                 495     


Gly Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
            500                 505                 510         


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Val Lys 
        515                 520                 525             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    530                 535                 540                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
545                 550                 555                 560 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                565                 570                 575     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            580                 585                 590         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        595                 600                 605             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    610                 615                 620                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
625                 630                 635         


<210> 594
<211> 280
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 594
Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Phe Trp Val 
    130                 135                 140                 


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
145                 150                 155                 160 


Val Ala Phe Ile Ile Phe Trp Val Arg Val Lys Phe Ser Arg Ser Ala 
                165                 170                 175     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            180                 185                 190         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        195                 200                 205             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    210                 215                 220                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
225                 230                 235                 240 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                245                 250                 255     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            260                 265                 270         


His Met Gln Ala Leu Pro Pro Arg 
        275                 280 


<210> 595
<211> 259
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 595
Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
1               5                   10                  15      


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
            20                  25                  30          


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
        35                  40                  45              


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
    50                  55                  60                  


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
65                  70                  75                  80  


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr 
                85                  90                  95      


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
            100                 105                 110         


His Gly Ala Arg Phe Gln Ile Pro Phe Trp Val Leu Val Val Val Gly 
        115                 120                 125             


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
    130                 135                 140                 


Phe Trp Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
145                 150                 155                 160 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                165                 170                 175     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            180                 185                 190         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        195                 200                 205             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    210                 215                 220                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
225                 230                 235                 240 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                245                 250                 255     


Pro Pro Arg 
            


<210> 596
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 596
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Ala Leu Arg Asn Val 
        195                 200                 205             


Pro Phe Arg Ser Glu Val Leu Gly Trp Asp Pro Asp Ser Leu Ala Asp 
    210                 215                 220                 


Tyr Phe Lys Lys Leu Asn Tyr Lys Asp Cys Glu Lys Ala Val Lys Lys 
225                 230                 235                 240 


Tyr His Ile Asp Gly Ala Arg Phe Leu Asn Leu Thr Glu Asn Asp Ile 
                245                 250                 255     


Gln Lys Phe Pro Lys Leu Arg Val Pro Ile Leu Ser Lys Leu Ser Gln 
            260                 265                 270         


Glu Ile Asn Lys Asn Glu Glu Arg Arg Ser Ile Phe Thr Arg Lys Pro 
        275                 280                 285             


Gln Val Pro Arg Phe Pro Glu Glu Thr Glu Ser His Glu Glu Asp Asn 
    290                 295                 300                 


Gly Gly Trp Ser Ser Phe Glu Glu Asp Asp Tyr Glu Ser Pro Asn Asp 
305                 310                 315                 320 


Asp Gln Asp Gly Glu Asp Asp Gly Asp Tyr Glu Ser Pro Asn Glu Glu 
                325                 330                 335     


Glu Glu Ala Pro Val Glu Asp Asp Ala Asp Tyr Glu Pro Pro Pro Ser 
            340                 345                 350         


Asn Asp Glu Glu Ala Leu Gln Asn Ser Ile Leu Pro Ala Lys Pro Phe 
        355                 360                 365             


Pro Asn Ser Asn Ser Met Tyr Ile Asp Arg Pro Pro Ser Gly Lys Thr 
    370                 375                 380                 


Pro Gln Gln Pro Pro Val Pro Pro Gln Arg Pro Met Ala Ala Leu Pro 
385                 390                 395                 400 


Pro Pro Pro Ala Gly Arg Asn His Ser Pro Leu Pro Pro Pro Gln Thr 
                405                 410                 415     


Asn His Glu Glu Pro Ser Arg Ser Arg Asn His Lys Thr Ala Lys Leu 
            420                 425                 430         


Pro Ala Pro Ser Ile Asp Arg Ser Thr Lys Pro Pro Leu Asp Arg Ser 
        435                 440                 445             


Leu Ala Pro Phe Asp Arg Glu Pro Phe Thr Leu Gly Lys Lys Pro Pro 
    450                 455                 460                 


Phe Ser Asp Lys Pro Ser Ile Pro Ala Gly Arg Ser Leu Gly Glu His 
465                 470                 475                 480 


Leu Pro Lys Ile Gln Lys Pro Pro Leu Pro Pro Thr Thr Glu Arg His 
                485                 490                 495     


Glu Arg Ser Ser Pro Leu Pro Gly Lys Lys Pro Pro Val Pro Lys His 
            500                 505                 510         


Gly Trp Gly Pro Asp Arg Arg Glu Asn Asp Glu Asp Asp Val His Gln 
        515                 520                 525             


Arg Pro Leu Pro Gln Pro Ala Leu Leu Pro Met Ser Ser Asn Thr Phe 
    530                 535                 540                 


Pro Ser Arg Ser Thr Lys Pro Ser Pro Met Asn Pro Leu Pro Ser Ser 
545                 550                 555                 560 


His Met Pro Gly Ala Phe Ser Glu Ser Asn Ser Ser Phe Pro Gln Ser 
                565                 570                 575     


Ala Ser Leu Pro Pro Tyr Phe Ser Gln Gly Pro Ser Asn Arg Pro Pro 
            580                 585                 590         


Ile Arg Ala Glu Gly Arg Asn Phe Pro Leu Pro Leu Pro Asn Lys Pro 
        595                 600                 605             


Arg Pro Pro Ser Pro Ala Glu Glu Glu Asn Ser Leu Asn Glu Glu Trp 
    610                 615                 620                 


Tyr Val Ser Tyr Ile Thr Arg Pro Glu Ala Glu Ala Ala Leu Arg Lys 
625                 630                 635                 640 


Ile Asn Gln Asp Gly Thr Phe Leu Val Arg Asp Ser Ser Lys Lys Thr 
                645                 650                 655     


Thr Thr Asn Pro Tyr Val Leu Met Val Leu Tyr Lys Asp Lys Val Tyr 
            660                 665                 670         


Asn Ile Gln Ile Arg Tyr Gln Lys Glu Ser Gln Val Tyr Leu Leu Gly 
        675                 680                 685             


Thr Gly Leu Arg Gly Lys Glu Asp Phe Leu Ser Val Ser Asp Ile Ile 
    690                 695                 700                 


Asp Tyr Phe Arg Lys Met Pro Leu Leu Leu Ile Asp Gly Lys Asn Arg 
705                 710                 715                 720 


Gly Ser Arg Tyr Gln Cys Thr Leu Thr His Ala Ala Gly Tyr Pro 
                725                 730                 735 


<210> 597
<211> 713
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 597
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                165                 170                 175     


Arg Leu Leu His Ser Ala Leu Arg Asn Val Pro Phe Arg Ser Glu Val 
            180                 185                 190         


Leu Gly Trp Asp Pro Asp Ser Leu Ala Asp Tyr Phe Lys Lys Leu Asn 
        195                 200                 205             


Tyr Lys Asp Cys Glu Lys Ala Val Lys Lys Tyr His Ile Asp Gly Ala 
    210                 215                 220                 


Arg Phe Leu Asn Leu Thr Glu Asn Asp Ile Gln Lys Phe Pro Lys Leu 
225                 230                 235                 240 


Arg Val Pro Ile Leu Ser Lys Leu Ser Gln Glu Ile Asn Lys Asn Glu 
                245                 250                 255     


Glu Arg Arg Ser Ile Phe Thr Arg Lys Pro Gln Val Pro Arg Phe Pro 
            260                 265                 270         


Glu Glu Thr Glu Ser His Glu Glu Asp Asn Gly Gly Trp Ser Ser Phe 
        275                 280                 285             


Glu Glu Asp Asp Tyr Glu Ser Pro Asn Asp Asp Gln Asp Gly Glu Asp 
    290                 295                 300                 


Asp Gly Asp Tyr Glu Ser Pro Asn Glu Glu Glu Glu Ala Pro Val Glu 
305                 310                 315                 320 


Asp Asp Ala Asp Tyr Glu Pro Pro Pro Ser Asn Asp Glu Glu Ala Leu 
                325                 330                 335     


Gln Asn Ser Ile Leu Pro Ala Lys Pro Phe Pro Asn Ser Asn Ser Met 
            340                 345                 350         


Tyr Ile Asp Arg Pro Pro Ser Gly Lys Thr Pro Gln Gln Pro Pro Val 
        355                 360                 365             


Pro Pro Gln Arg Pro Met Ala Ala Leu Pro Pro Pro Pro Ala Gly Arg 
    370                 375                 380                 


Asn His Ser Pro Leu Pro Pro Pro Gln Thr Asn His Glu Glu Pro Ser 
385                 390                 395                 400 


Arg Ser Arg Asn His Lys Thr Ala Lys Leu Pro Ala Pro Ser Ile Asp 
                405                 410                 415     


Arg Ser Thr Lys Pro Pro Leu Asp Arg Ser Leu Ala Pro Phe Asp Arg 
            420                 425                 430         


Glu Pro Phe Thr Leu Gly Lys Lys Pro Pro Phe Ser Asp Lys Pro Ser 
        435                 440                 445             


Ile Pro Ala Gly Arg Ser Leu Gly Glu His Leu Pro Lys Ile Gln Lys 
    450                 455                 460                 


Pro Pro Leu Pro Pro Thr Thr Glu Arg His Glu Arg Ser Ser Pro Leu 
465                 470                 475                 480 


Pro Gly Lys Lys Pro Pro Val Pro Lys His Gly Trp Gly Pro Asp Arg 
                485                 490                 495     


Arg Glu Asn Asp Glu Asp Asp Val His Gln Arg Pro Leu Pro Gln Pro 
            500                 505                 510         


Ala Leu Leu Pro Met Ser Ser Asn Thr Phe Pro Ser Arg Ser Thr Lys 
        515                 520                 525             


Pro Ser Pro Met Asn Pro Leu Pro Ser Ser His Met Pro Gly Ala Phe 
    530                 535                 540                 


Ser Glu Ser Asn Ser Ser Phe Pro Gln Ser Ala Ser Leu Pro Pro Tyr 
545                 550                 555                 560 


Phe Ser Gln Gly Pro Ser Asn Arg Pro Pro Ile Arg Ala Glu Gly Arg 
                565                 570                 575     


Asn Phe Pro Leu Pro Leu Pro Asn Lys Pro Arg Pro Pro Ser Pro Ala 
            580                 585                 590         


Glu Glu Glu Asn Ser Leu Asn Glu Glu Trp Tyr Val Ser Tyr Ile Thr 
        595                 600                 605             


Arg Pro Glu Ala Glu Ala Ala Leu Arg Lys Ile Asn Gln Asp Gly Thr 
    610                 615                 620                 


Phe Leu Val Arg Asp Ser Ser Lys Lys Thr Thr Thr Asn Pro Tyr Val 
625                 630                 635                 640 


Leu Met Val Leu Tyr Lys Asp Lys Val Tyr Asn Ile Gln Ile Arg Tyr 
                645                 650                 655     


Gln Lys Glu Ser Gln Val Tyr Leu Leu Gly Thr Gly Leu Arg Gly Lys 
            660                 665                 670         


Glu Asp Phe Leu Ser Val Ser Asp Ile Ile Asp Tyr Phe Arg Lys Met 
        675                 680                 685             


Pro Leu Leu Leu Ile Asp Gly Lys Asn Arg Gly Ser Arg Tyr Gln Cys 
    690                 695                 700                 


Thr Leu Thr His Ala Ala Gly Tyr Pro 
705                 710             


<210> 598
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 598
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Ala Ala Gly Gly Pro 
        195                 200                 205             


Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser Leu Pro Leu 
    210                 215                 220                 


Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu Phe Leu Asn 
225                 230                 235                 240 


Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala Glu Glu Met 
                245                 250                 255     


Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln Ala Asp Pro 
            260                 265                 270         


Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly Ala Ser Val 
        275                 280                 285             


Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp Asp Val Leu 
    290                 295                 300                 


Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln Lys Tyr Ile Leu 
305                 310                 315                 320 


Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln Val Ala Ala Val 
                325                 330                 335     


Asp Ser Ser Val Pro Arg Thr Ala Glu Leu Ala Gly Ile Thr Thr Leu 
            340                 345                 350         


Asp Asp Pro Leu Gly His Met Pro Glu Arg Phe Asp Ala Phe Ile Cys 
        355                 360                 365             


Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln Glu Met Ile Arg Gln Leu 
    370                 375                 380                 


Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys Val Ser Asp Arg Asp Val 
385                 390                 395                 400 


Leu Pro Gly Thr Cys Val Trp Ser Ile Ala Ser Glu Leu Ile Glu Lys 
                405                 410                 415     


Arg Cys Arg Arg Met Val Val Val Val Ser Asp Asp Tyr Leu Gln Ser 
            420                 425                 430         


Lys Glu Cys Asp Phe Gln Thr Lys Phe Ala Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Ala His Gln Lys Arg Leu Ile Pro Ile Lys Tyr Lys Ala Met Lys Lys 
    450                 455                 460                 


Glu Phe Pro Ser Ile Leu Arg Phe Ile Thr Val Cys Asp Tyr Thr Asn 
465                 470                 475                 480 


Pro Cys Thr Lys Ser Trp Phe Trp Thr Arg Leu Ala Lys Ala Leu Ser 
                485                 490                 495     


Leu Pro 
        


<210> 599
<211> 476
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 599
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                165                 170                 175     


Arg Leu Leu His Ser Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala 
            180                 185                 190         


Pro Val Ser Ser Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg 
        195                 200                 205             


Val Arg Arg Arg Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala 
    210                 215                 220                 


Ala Asp Trp Thr Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu 
225                 230                 235                 240 


Ile Arg Gln Leu Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp 
                245                 250                 255     


Ala Trp Gln Gly Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu 
            260                 265                 270         


Leu Thr Lys Leu Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser 
        275                 280                 285             


Ile Glu Glu Asp Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu 
    290                 295                 300                 


Ala Glu Lys Pro Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg 
305                 310                 315                 320 


Thr Ala Glu Leu Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His 
                325                 330                 335     


Met Pro Glu Arg Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile 
            340                 345                 350         


Gln Phe Val Gln Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg 
        355                 360                 365             


Leu Lys Leu Cys Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val 
    370                 375                 380                 


Trp Ser Ile Ala Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met Val 
385                 390                 395                 400 


Val Val Val Ser Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe Gln 
                405                 410                 415     


Thr Lys Phe Ala Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg Leu 
            420                 425                 430         


Ile Pro Ile Lys Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile Leu 
        435                 440                 445             


Arg Phe Ile Thr Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp 
    450                 455                 460                 


Phe Trp Thr Arg Leu Ala Lys Ala Leu Ser Leu Pro 
465                 470                 475     


<210> 600
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 600
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Gly Val Leu Ala Gly Ile Val Met Gly Asp 
                165                 170                 175     


Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu Gly Arg 
            180                 185                 190         


Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg Lys Gln 
        195                 200                 205             


Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg 
    210                 215                 220                 


Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
225                 230                 235                 


<210> 601
<211> 217
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 601
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Gly Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu 
145                 150                 155                 160 


Ile Ala Leu Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg 
                165                 170                 175     


Gly Ala Ala Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu 
            180                 185                 190         


Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp 
        195                 200                 205             


Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
    210                 215         


<210> 602
<211> 618
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 602
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Ala Ser Ser Ser Gly 
        195                 200                 205             


Ser Ser Pro Arg Pro Ala Pro Asp Glu Asn Glu Phe Pro Phe Gly Cys 
    210                 215                 220                 


Pro Pro Thr Val Cys Gln Asp Pro Lys Glu Pro Arg Ala Leu Cys Cys 
225                 230                 235                 240 


Ala Gly Cys Leu Ser Glu Asn Pro Arg Asn Gly Glu Asp Gln Ile Cys 
                245                 250                 255     


Pro Lys Cys Arg Gly Glu Asp Leu Gln Ser Ile Ser Pro Gly Ser Arg 
            260                 265                 270         


Leu Arg Thr Gln Glu Lys Ala His Pro Glu Val Ala Glu Ala Gly Ile 
        275                 280                 285             


Gly Cys Pro Phe Ala Gly Val Gly Cys Ser Phe Lys Gly Ser Pro Gln 
    290                 295                 300                 


Ser Val Gln Glu His Glu Val Thr Ser Gln Thr Ser His Leu Asn Leu 
305                 310                 315                 320 


Leu Leu Gly Phe Met Lys Gln Trp Lys Ala Arg Leu Gly Cys Gly Leu 
                325                 330                 335     


Glu Ser Gly Pro Met Ala Leu Glu Gln Asn Leu Ser Asp Leu Gln Leu 
            340                 345                 350         


Gln Ala Ala Val Glu Val Ala Gly Asp Leu Glu Val Asp Cys Tyr Arg 
        355                 360                 365             


Ala Pro Cys Ser Glu Ser Gln Glu Glu Leu Ala Leu Gln His Phe Met 
    370                 375                 380                 


Lys Glu Lys Leu Leu Ala Glu Leu Glu Gly Lys Leu Arg Val Phe Glu 
385                 390                 395                 400 


Asn Ile Val Ala Val Leu Asn Lys Glu Val Glu Ala Ser His Leu Ala 
                405                 410                 415     


Leu Ala Thr Ser Ile His Gln Ser Gln Leu Asp Arg Glu Arg Ile Leu 
            420                 425                 430         


Ser Leu Glu Gln Arg Val Val Glu Leu Gln Gln Thr Leu Ala Gln Lys 
        435                 440                 445             


Asp Gln Ala Leu Gly Lys Leu Glu Gln Ser Leu Arg Leu Met Glu Glu 
    450                 455                 460                 


Ala Ser Phe Asp Gly Thr Phe Leu Trp Lys Ile Thr Asn Val Thr Arg 
465                 470                 475                 480 


Arg Cys His Glu Ser Ala Cys Gly Arg Thr Val Ser Leu Phe Ser Pro 
                485                 490                 495     


Ala Phe Tyr Thr Ala Lys Tyr Gly Tyr Lys Leu Cys Leu Arg Leu Tyr 
            500                 505                 510         


Leu Asn Gly Asp Gly Thr Gly Lys Arg Thr His Leu Ser Leu Phe Ile 
        515                 520                 525             


Val Ile Met Arg Gly Glu Tyr Asp Ala Leu Leu Pro Trp Pro Phe Arg 
    530                 535                 540                 


Asn Lys Val Thr Phe Met Leu Leu Asp Gln Asn Asn Arg Glu His Ala 
545                 550                 555                 560 


Ile Asp Ala Phe Arg Pro Asp Leu Ser Ser Ala Ser Phe Gln Arg Pro 
                565                 570                 575     


Gln Ser Glu Thr Asn Val Ala Ser Gly Cys Pro Leu Phe Phe Pro Leu 
            580                 585                 590         


Ser Lys Leu Gln Ser Pro Lys His Ala Tyr Val Lys Asp Asp Thr Met 
        595                 600                 605             


Phe Leu Lys Cys Ile Val Glu Thr Ser Thr 
    610                 615             


<210> 603
<211> 596
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 603
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                165                 170                 175     


Arg Leu Leu His Ser Ala Ser Ser Ser Gly Ser Ser Pro Arg Pro Ala 
            180                 185                 190         


Pro Asp Glu Asn Glu Phe Pro Phe Gly Cys Pro Pro Thr Val Cys Gln 
        195                 200                 205             


Asp Pro Lys Glu Pro Arg Ala Leu Cys Cys Ala Gly Cys Leu Ser Glu 
    210                 215                 220                 


Asn Pro Arg Asn Gly Glu Asp Gln Ile Cys Pro Lys Cys Arg Gly Glu 
225                 230                 235                 240 


Asp Leu Gln Ser Ile Ser Pro Gly Ser Arg Leu Arg Thr Gln Glu Lys 
                245                 250                 255     


Ala His Pro Glu Val Ala Glu Ala Gly Ile Gly Cys Pro Phe Ala Gly 
            260                 265                 270         


Val Gly Cys Ser Phe Lys Gly Ser Pro Gln Ser Val Gln Glu His Glu 
        275                 280                 285             


Val Thr Ser Gln Thr Ser His Leu Asn Leu Leu Leu Gly Phe Met Lys 
    290                 295                 300                 


Gln Trp Lys Ala Arg Leu Gly Cys Gly Leu Glu Ser Gly Pro Met Ala 
305                 310                 315                 320 


Leu Glu Gln Asn Leu Ser Asp Leu Gln Leu Gln Ala Ala Val Glu Val 
                325                 330                 335     


Ala Gly Asp Leu Glu Val Asp Cys Tyr Arg Ala Pro Cys Ser Glu Ser 
            340                 345                 350         


Gln Glu Glu Leu Ala Leu Gln His Phe Met Lys Glu Lys Leu Leu Ala 
        355                 360                 365             


Glu Leu Glu Gly Lys Leu Arg Val Phe Glu Asn Ile Val Ala Val Leu 
    370                 375                 380                 


Asn Lys Glu Val Glu Ala Ser His Leu Ala Leu Ala Thr Ser Ile His 
385                 390                 395                 400 


Gln Ser Gln Leu Asp Arg Glu Arg Ile Leu Ser Leu Glu Gln Arg Val 
                405                 410                 415     


Val Glu Leu Gln Gln Thr Leu Ala Gln Lys Asp Gln Ala Leu Gly Lys 
            420                 425                 430         


Leu Glu Gln Ser Leu Arg Leu Met Glu Glu Ala Ser Phe Asp Gly Thr 
        435                 440                 445             


Phe Leu Trp Lys Ile Thr Asn Val Thr Arg Arg Cys His Glu Ser Ala 
    450                 455                 460                 


Cys Gly Arg Thr Val Ser Leu Phe Ser Pro Ala Phe Tyr Thr Ala Lys 
465                 470                 475                 480 


Tyr Gly Tyr Lys Leu Cys Leu Arg Leu Tyr Leu Asn Gly Asp Gly Thr 
                485                 490                 495     


Gly Lys Arg Thr His Leu Ser Leu Phe Ile Val Ile Met Arg Gly Glu 
            500                 505                 510         


Tyr Asp Ala Leu Leu Pro Trp Pro Phe Arg Asn Lys Val Thr Phe Met 
        515                 520                 525             


Leu Leu Asp Gln Asn Asn Arg Glu His Ala Ile Asp Ala Phe Arg Pro 
    530                 535                 540                 


Asp Leu Ser Ser Ala Ser Phe Gln Arg Pro Gln Ser Glu Thr Asn Val 
545                 550                 555                 560 


Ala Ser Gly Cys Pro Leu Phe Phe Pro Leu Ser Lys Leu Gln Ser Pro 
                565                 570                 575     


Lys His Ala Tyr Val Lys Asp Asp Thr Met Phe Leu Lys Cys Ile Val 
            580                 585                 590         


Glu Thr Ser Thr 
        595     


<210> 604
<211> 703
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 604
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Ala Ala Ala Ser Val 
        195                 200                 205             


Thr Pro Pro Gly Ser Leu Glu Leu Leu Gln Pro Gly Phe Ser Lys Thr 
    210                 215                 220                 


Leu Leu Gly Thr Lys Leu Glu Ala Lys Tyr Leu Cys Ser Ala Cys Arg 
225                 230                 235                 240 


Asn Val Leu Arg Arg Pro Phe Gln Ala Gln Cys Gly His Arg Tyr Cys 
                245                 250                 255     


Ser Phe Cys Leu Ala Ser Ile Leu Ser Ser Gly Pro Gln Asn Cys Ala 
            260                 265                 270         


Ala Cys Val His Glu Gly Ile Tyr Glu Glu Gly Ile Ser Ile Leu Glu 
        275                 280                 285             


Ser Ser Ser Ala Phe Pro Asp Asn Ala Ala Arg Arg Glu Val Glu Ser 
    290                 295                 300                 


Leu Pro Ala Val Cys Pro Ser Asp Gly Cys Thr Trp Lys Gly Thr Leu 
305                 310                 315                 320 


Lys Glu Tyr Glu Ser Cys His Glu Gly Arg Cys Pro Leu Met Leu Thr 
                325                 330                 335     


Glu Cys Pro Ala Cys Lys Gly Leu Val Arg Leu Gly Glu Lys Glu Arg 
            340                 345                 350         


His Leu Glu His Glu Cys Pro Glu Arg Ser Leu Ser Cys Arg His Cys 
        355                 360                 365             


Arg Ala Pro Cys Cys Gly Ala Asp Val Lys Ala His His Glu Val Cys 
    370                 375                 380                 


Pro Lys Phe Pro Leu Thr Cys Asp Gly Cys Gly Lys Lys Lys Ile Pro 
385                 390                 395                 400 


Arg Glu Lys Phe Gln Asp His Val Lys Thr Cys Gly Lys Cys Arg Val 
                405                 410                 415     


Pro Cys Arg Phe His Ala Ile Gly Cys Leu Glu Thr Val Glu Gly Glu 
            420                 425                 430         


Lys Gln Gln Glu His Glu Val Gln Trp Leu Arg Glu His Leu Ala Met 
        435                 440                 445             


Leu Leu Ser Ser Val Leu Glu Ala Lys Pro Leu Leu Gly Asp Gln Ser 
    450                 455                 460                 


His Ala Gly Ser Glu Leu Leu Gln Arg Cys Glu Ser Leu Glu Lys Lys 
465                 470                 475                 480 


Thr Ala Thr Phe Glu Asn Ile Val Cys Val Leu Asn Arg Glu Val Glu 
                485                 490                 495     


Arg Val Ala Met Thr Ala Glu Ala Cys Ser Arg Gln His Arg Leu Asp 
            500                 505                 510         


Gln Asp Lys Ile Glu Ala Leu Ser Ser Lys Val Gln Gln Leu Glu Arg 
        515                 520                 525             


Ser Ile Gly Leu Lys Asp Leu Ala Met Ala Asp Leu Glu Gln Lys Val 
    530                 535                 540                 


Leu Glu Met Glu Ala Ser Thr Tyr Asp Gly Val Phe Ile Trp Lys Ile 
545                 550                 555                 560 


Ser Asp Phe Ala Arg Lys Arg Gln Glu Ala Val Ala Gly Arg Ile Pro 
                565                 570                 575     


Ala Ile Phe Ser Pro Ala Phe Tyr Thr Ser Arg Tyr Gly Tyr Lys Met 
            580                 585                 590         


Cys Leu Arg Ile Tyr Leu Asn Gly Asp Gly Thr Gly Arg Gly Thr His 
        595                 600                 605             


Leu Ser Leu Phe Phe Val Val Met Lys Gly Pro Asn Asp Ala Leu Leu 
    610                 615                 620                 


Arg Trp Pro Phe Asn Gln Lys Val Thr Leu Met Leu Leu Asp Gln Asn 
625                 630                 635                 640 


Asn Arg Glu His Val Ile Asp Ala Phe Arg Pro Asp Val Thr Ser Ser 
                645                 650                 655     


Ser Phe Gln Arg Pro Val Asn Asp Met Asn Ile Ala Ser Gly Cys Pro 
            660                 665                 670         


Leu Phe Cys Pro Val Ser Lys Met Glu Ala Lys Asn Ser Tyr Val Arg 
        675                 680                 685             


Asp Asp Ala Ile Phe Ile Lys Ala Ile Val Asp Leu Thr Gly Leu 
    690                 695                 700             


<210> 605
<211> 681
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 605
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                165                 170                 175     


Arg Leu Leu His Ser Ala Ala Ala Ser Val Thr Pro Pro Gly Ser Leu 
            180                 185                 190         


Glu Leu Leu Gln Pro Gly Phe Ser Lys Thr Leu Leu Gly Thr Lys Leu 
        195                 200                 205             


Glu Ala Lys Tyr Leu Cys Ser Ala Cys Arg Asn Val Leu Arg Arg Pro 
    210                 215                 220                 


Phe Gln Ala Gln Cys Gly His Arg Tyr Cys Ser Phe Cys Leu Ala Ser 
225                 230                 235                 240 


Ile Leu Ser Ser Gly Pro Gln Asn Cys Ala Ala Cys Val His Glu Gly 
                245                 250                 255     


Ile Tyr Glu Glu Gly Ile Ser Ile Leu Glu Ser Ser Ser Ala Phe Pro 
            260                 265                 270         


Asp Asn Ala Ala Arg Arg Glu Val Glu Ser Leu Pro Ala Val Cys Pro 
        275                 280                 285             


Ser Asp Gly Cys Thr Trp Lys Gly Thr Leu Lys Glu Tyr Glu Ser Cys 
    290                 295                 300                 


His Glu Gly Arg Cys Pro Leu Met Leu Thr Glu Cys Pro Ala Cys Lys 
305                 310                 315                 320 


Gly Leu Val Arg Leu Gly Glu Lys Glu Arg His Leu Glu His Glu Cys 
                325                 330                 335     


Pro Glu Arg Ser Leu Ser Cys Arg His Cys Arg Ala Pro Cys Cys Gly 
            340                 345                 350         


Ala Asp Val Lys Ala His His Glu Val Cys Pro Lys Phe Pro Leu Thr 
        355                 360                 365             


Cys Asp Gly Cys Gly Lys Lys Lys Ile Pro Arg Glu Lys Phe Gln Asp 
    370                 375                 380                 


His Val Lys Thr Cys Gly Lys Cys Arg Val Pro Cys Arg Phe His Ala 
385                 390                 395                 400 


Ile Gly Cys Leu Glu Thr Val Glu Gly Glu Lys Gln Gln Glu His Glu 
                405                 410                 415     


Val Gln Trp Leu Arg Glu His Leu Ala Met Leu Leu Ser Ser Val Leu 
            420                 425                 430         


Glu Ala Lys Pro Leu Leu Gly Asp Gln Ser His Ala Gly Ser Glu Leu 
        435                 440                 445             


Leu Gln Arg Cys Glu Ser Leu Glu Lys Lys Thr Ala Thr Phe Glu Asn 
    450                 455                 460                 


Ile Val Cys Val Leu Asn Arg Glu Val Glu Arg Val Ala Met Thr Ala 
465                 470                 475                 480 


Glu Ala Cys Ser Arg Gln His Arg Leu Asp Gln Asp Lys Ile Glu Ala 
                485                 490                 495     


Leu Ser Ser Lys Val Gln Gln Leu Glu Arg Ser Ile Gly Leu Lys Asp 
            500                 505                 510         


Leu Ala Met Ala Asp Leu Glu Gln Lys Val Leu Glu Met Glu Ala Ser 
        515                 520                 525             


Thr Tyr Asp Gly Val Phe Ile Trp Lys Ile Ser Asp Phe Ala Arg Lys 
    530                 535                 540                 


Arg Gln Glu Ala Val Ala Gly Arg Ile Pro Ala Ile Phe Ser Pro Ala 
545                 550                 555                 560 


Phe Tyr Thr Ser Arg Tyr Gly Tyr Lys Met Cys Leu Arg Ile Tyr Leu 
                565                 570                 575     


Asn Gly Asp Gly Thr Gly Arg Gly Thr His Leu Ser Leu Phe Phe Val 
            580                 585                 590         


Val Met Lys Gly Pro Asn Asp Ala Leu Leu Arg Trp Pro Phe Asn Gln 
        595                 600                 605             


Lys Val Thr Leu Met Leu Leu Asp Gln Asn Asn Arg Glu His Val Ile 
    610                 615                 620                 


Asp Ala Phe Arg Pro Asp Val Thr Ser Ser Ser Phe Gln Arg Pro Val 
625                 630                 635                 640 


Asn Asp Met Asn Ile Ala Ser Gly Cys Pro Leu Phe Cys Pro Val Ser 
                645                 650                 655     


Lys Met Glu Ala Lys Asn Ser Tyr Val Arg Asp Asp Ala Ile Phe Ile 
            660                 665                 670         


Lys Ala Ile Val Asp Leu Thr Gly Leu 
        675                 680     


<210> 606
<211> 770
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 606
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Glu Ser Ser Lys Lys 
        195                 200                 205             


Met Asp Ser Pro Gly Ala Leu Gln Thr Asn Pro Pro Leu Lys Leu His 
    210                 215                 220                 


Thr Asp Arg Ser Ala Gly Thr Pro Val Phe Val Pro Glu Gln Gly Gly 
225                 230                 235                 240 


Tyr Lys Glu Lys Phe Val Lys Thr Val Glu Asp Lys Tyr Lys Cys Glu 
                245                 250                 255     


Lys Cys His Leu Val Leu Cys Ser Pro Lys Gln Thr Glu Cys Gly His 
            260                 265                 270         


Arg Phe Cys Glu Ser Cys Met Ala Ala Leu Leu Ser Ser Ser Ser Pro 
        275                 280                 285             


Lys Cys Thr Ala Cys Gln Glu Ser Ile Val Lys Asp Lys Val Phe Lys 
    290                 295                 300                 


Asp Asn Cys Cys Lys Arg Glu Ile Leu Ala Leu Gln Ile Tyr Cys Arg 
305                 310                 315                 320 


Asn Glu Ser Arg Gly Cys Ala Glu Gln Leu Met Leu Gly His Leu Leu 
                325                 330                 335     


Val His Leu Lys Asn Asp Cys His Phe Glu Glu Leu Pro Cys Val Arg 
            340                 345                 350         


Pro Asp Cys Lys Glu Lys Val Leu Arg Lys Asp Leu Arg Asp His Val 
        355                 360                 365             


Glu Lys Ala Cys Lys Tyr Arg Glu Ala Thr Cys Ser His Cys Lys Ser 
    370                 375                 380                 


Gln Val Pro Met Ile Ala Leu Gln Lys His Glu Asp Thr Asp Cys Pro 
385                 390                 395                 400 


Cys Val Val Val Ser Cys Pro His Lys Cys Ser Val Gln Thr Leu Leu 
                405                 410                 415     


Arg Ser Glu Leu Ser Ala His Leu Ser Glu Cys Val Asn Ala Pro Ser 
            420                 425                 430         


Thr Cys Ser Phe Lys Arg Tyr Gly Cys Val Phe Gln Gly Thr Asn Gln 
        435                 440                 445             


Gln Ile Lys Ala His Glu Ala Ser Ser Ala Val Gln His Val Asn Leu 
    450                 455                 460                 


Leu Lys Glu Trp Ser Asn Ser Leu Glu Lys Lys Val Ser Leu Leu Gln 
465                 470                 475                 480 


Asn Glu Ser Val Glu Lys Asn Lys Ser Ile Gln Ser Leu His Asn Gln 
                485                 490                 495     


Ile Cys Ser Phe Glu Ile Glu Ile Glu Arg Gln Lys Glu Met Leu Arg 
            500                 505                 510         


Asn Asn Glu Ser Lys Ile Leu His Leu Gln Arg Val Ile Asp Ser Gln 
        515                 520                 525             


Ala Glu Lys Leu Lys Glu Leu Asp Lys Glu Ile Arg Pro Phe Arg Gln 
    530                 535                 540                 


Asn Trp Glu Glu Ala Asp Ser Met Lys Ser Ser Val Glu Ser Leu Gln 
545                 550                 555                 560 


Asn Arg Val Thr Glu Leu Glu Ser Val Asp Lys Ser Ala Gly Gln Val 
                565                 570                 575     


Ala Arg Asn Thr Gly Leu Leu Glu Ser Gln Leu Ser Arg His Asp Gln 
            580                 585                 590         


Met Leu Ser Val His Asp Ile Arg Leu Ala Asp Met Asp Leu Arg Phe 
        595                 600                 605             


Gln Val Leu Glu Thr Ala Ser Tyr Asn Gly Val Leu Ile Trp Lys Ile 
    610                 615                 620                 


Arg Asp Tyr Lys Arg Arg Lys Gln Glu Ala Val Met Gly Lys Thr Leu 
625                 630                 635                 640 


Ser Leu Tyr Ser Gln Pro Phe Tyr Thr Gly Tyr Phe Gly Tyr Lys Met 
                645                 650                 655     


Cys Ala Arg Val Tyr Leu Asn Gly Asp Gly Met Gly Lys Gly Thr His 
            660                 665                 670         


Leu Ser Leu Phe Phe Val Ile Met Arg Gly Glu Tyr Asp Ala Leu Leu 
        675                 680                 685             


Pro Trp Pro Phe Lys Gln Lys Val Thr Leu Met Leu Met Asp Gln Gly 
    690                 695                 700                 


Ser Ser Arg Arg His Leu Gly Asp Ala Phe Lys Pro Asp Pro Asn Ser 
705                 710                 715                 720 


Ser Ser Phe Lys Lys Pro Thr Gly Glu Met Asn Ile Ala Ser Gly Cys 
                725                 730                 735     


Pro Val Phe Val Ala Gln Thr Val Leu Glu Asn Gly Thr Tyr Ile Lys 
            740                 745                 750         


Asp Asp Thr Ile Phe Ile Lys Val Ile Val Asp Thr Ser Asp Leu Pro 
        755                 760                 765             


Asp Pro 
    770 


<210> 607
<211> 748
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 607
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                165                 170                 175     


Arg Leu Leu His Ser Glu Ser Ser Lys Lys Met Asp Ser Pro Gly Ala 
            180                 185                 190         


Leu Gln Thr Asn Pro Pro Leu Lys Leu His Thr Asp Arg Ser Ala Gly 
        195                 200                 205             


Thr Pro Val Phe Val Pro Glu Gln Gly Gly Tyr Lys Glu Lys Phe Val 
    210                 215                 220                 


Lys Thr Val Glu Asp Lys Tyr Lys Cys Glu Lys Cys His Leu Val Leu 
225                 230                 235                 240 


Cys Ser Pro Lys Gln Thr Glu Cys Gly His Arg Phe Cys Glu Ser Cys 
                245                 250                 255     


Met Ala Ala Leu Leu Ser Ser Ser Ser Pro Lys Cys Thr Ala Cys Gln 
            260                 265                 270         


Glu Ser Ile Val Lys Asp Lys Val Phe Lys Asp Asn Cys Cys Lys Arg 
        275                 280                 285             


Glu Ile Leu Ala Leu Gln Ile Tyr Cys Arg Asn Glu Ser Arg Gly Cys 
    290                 295                 300                 


Ala Glu Gln Leu Met Leu Gly His Leu Leu Val His Leu Lys Asn Asp 
305                 310                 315                 320 


Cys His Phe Glu Glu Leu Pro Cys Val Arg Pro Asp Cys Lys Glu Lys 
                325                 330                 335     


Val Leu Arg Lys Asp Leu Arg Asp His Val Glu Lys Ala Cys Lys Tyr 
            340                 345                 350         


Arg Glu Ala Thr Cys Ser His Cys Lys Ser Gln Val Pro Met Ile Ala 
        355                 360                 365             


Leu Gln Lys His Glu Asp Thr Asp Cys Pro Cys Val Val Val Ser Cys 
    370                 375                 380                 


Pro His Lys Cys Ser Val Gln Thr Leu Leu Arg Ser Glu Leu Ser Ala 
385                 390                 395                 400 


His Leu Ser Glu Cys Val Asn Ala Pro Ser Thr Cys Ser Phe Lys Arg 
                405                 410                 415     


Tyr Gly Cys Val Phe Gln Gly Thr Asn Gln Gln Ile Lys Ala His Glu 
            420                 425                 430         


Ala Ser Ser Ala Val Gln His Val Asn Leu Leu Lys Glu Trp Ser Asn 
        435                 440                 445             


Ser Leu Glu Lys Lys Val Ser Leu Leu Gln Asn Glu Ser Val Glu Lys 
    450                 455                 460                 


Asn Lys Ser Ile Gln Ser Leu His Asn Gln Ile Cys Ser Phe Glu Ile 
465                 470                 475                 480 


Glu Ile Glu Arg Gln Lys Glu Met Leu Arg Asn Asn Glu Ser Lys Ile 
                485                 490                 495     


Leu His Leu Gln Arg Val Ile Asp Ser Gln Ala Glu Lys Leu Lys Glu 
            500                 505                 510         


Leu Asp Lys Glu Ile Arg Pro Phe Arg Gln Asn Trp Glu Glu Ala Asp 
        515                 520                 525             


Ser Met Lys Ser Ser Val Glu Ser Leu Gln Asn Arg Val Thr Glu Leu 
    530                 535                 540                 


Glu Ser Val Asp Lys Ser Ala Gly Gln Val Ala Arg Asn Thr Gly Leu 
545                 550                 555                 560 


Leu Glu Ser Gln Leu Ser Arg His Asp Gln Met Leu Ser Val His Asp 
                565                 570                 575     


Ile Arg Leu Ala Asp Met Asp Leu Arg Phe Gln Val Leu Glu Thr Ala 
            580                 585                 590         


Ser Tyr Asn Gly Val Leu Ile Trp Lys Ile Arg Asp Tyr Lys Arg Arg 
        595                 600                 605             


Lys Gln Glu Ala Val Met Gly Lys Thr Leu Ser Leu Tyr Ser Gln Pro 
    610                 615                 620                 


Phe Tyr Thr Gly Tyr Phe Gly Tyr Lys Met Cys Ala Arg Val Tyr Leu 
625                 630                 635                 640 


Asn Gly Asp Gly Met Gly Lys Gly Thr His Leu Ser Leu Phe Phe Val 
                645                 650                 655     


Ile Met Arg Gly Glu Tyr Asp Ala Leu Leu Pro Trp Pro Phe Lys Gln 
            660                 665                 670         


Lys Val Thr Leu Met Leu Met Asp Gln Gly Ser Ser Arg Arg His Leu 
        675                 680                 685             


Gly Asp Ala Phe Lys Pro Asp Pro Asn Ser Ser Ser Phe Lys Lys Pro 
    690                 695                 700                 


Thr Gly Glu Met Asn Ile Ala Ser Gly Cys Pro Val Phe Val Ala Gln 
705                 710                 715                 720 


Thr Val Leu Glu Asn Gly Thr Tyr Ile Lys Asp Asp Thr Ile Phe Ile 
                725                 730                 735     


Lys Val Ile Val Asp Thr Ser Asp Leu Pro Asp Pro 
            740                 745             


<210> 608
<211> 724
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 608
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Ser Leu Leu Asn Cys 
        195                 200                 205             


Glu Asn Ser Cys Gly Ser Ser Gln Ser Glu Ser Asp Cys Cys Val Ala 
    210                 215                 220                 


Met Ala Ser Ser Cys Ser Ala Val Thr Lys Asp Asp Ser Val Gly Gly 
225                 230                 235                 240 


Thr Ala Ser Thr Gly Asn Leu Ser Ser Ser Phe Met Glu Glu Ile Gln 
                245                 250                 255     


Gly Tyr Asp Val Glu Phe Asp Pro Pro Leu Glu Ser Lys Tyr Glu Cys 
            260                 265                 270         


Pro Ile Cys Leu Met Ala Leu Arg Glu Ala Val Gln Thr Pro Cys Gly 
        275                 280                 285             


His Arg Phe Cys Lys Ala Cys Ile Ile Lys Ser Ile Arg Asp Ala Gly 
    290                 295                 300                 


His Lys Cys Pro Val Asp Asn Glu Ile Leu Leu Glu Asn Gln Leu Phe 
305                 310                 315                 320 


Pro Asp Asn Phe Ala Lys Arg Glu Ile Leu Ser Leu Met Val Lys Cys 
                325                 330                 335     


Pro Asn Glu Gly Cys Leu His Lys Met Glu Leu Arg His Leu Glu Asp 
            340                 345                 350         


His Gln Ala His Cys Glu Phe Ala Leu Met Asp Cys Pro Gln Cys Gln 
        355                 360                 365             


Arg Pro Phe Gln Lys Phe His Ile Asn Ile His Ile Leu Lys Asp Cys 
    370                 375                 380                 


Pro Arg Arg Gln Val Ser Cys Asp Asn Cys Ala Ala Ser Met Ala Phe 
385                 390                 395                 400 


Glu Asp Lys Glu Ile His Asp Gln Asn Cys Pro Leu Ala Asn Val Ile 
                405                 410                 415     


Cys Glu Tyr Cys Asn Thr Ile Leu Ile Arg Glu Gln Met Pro Asn His 
            420                 425                 430         


Tyr Asp Leu Asp Cys Pro Thr Ala Pro Ile Pro Cys Thr Phe Ser Thr 
        435                 440                 445             


Phe Gly Cys His Glu Lys Met Gln Arg Asn His Leu Ala Arg His Leu 
    450                 455                 460                 


Gln Glu Asn Thr Gln Ser His Met Arg Met Leu Ala Gln Ala Val His 
465                 470                 475                 480 


Ser Leu Ser Val Ile Pro Asp Ser Gly Tyr Ile Ser Glu Val Arg Asn 
                485                 490                 495     


Phe Gln Glu Thr Ile His Gln Leu Glu Gly Arg Leu Val Arg Gln Asp 
            500                 505                 510         


His Gln Ile Arg Glu Leu Thr Ala Lys Met Glu Thr Gln Ser Met Tyr 
        515                 520                 525             


Val Ser Glu Leu Lys Arg Thr Ile Arg Thr Leu Glu Asp Lys Val Ala 
    530                 535                 540                 


Glu Ile Glu Ala Gln Gln Cys Asn Gly Ile Tyr Ile Trp Lys Ile Gly 
545                 550                 555                 560 


Asn Phe Gly Met His Leu Lys Cys Gln Glu Glu Glu Lys Pro Val Val 
                565                 570                 575     


Ile His Ser Pro Gly Phe Tyr Thr Gly Lys Pro Gly Tyr Lys Leu Cys 
            580                 585                 590         


Met Arg Leu His Leu Gln Leu Pro Thr Ala Gln Arg Cys Ala Asn Tyr 
        595                 600                 605             


Ile Ser Leu Phe Val His Thr Met Gln Gly Glu Tyr Asp Ser His Leu 
    610                 615                 620                 


Pro Trp Pro Phe Gln Gly Thr Ile Arg Leu Thr Ile Leu Asp Gln Ser 
625                 630                 635                 640 


Glu Ala Pro Val Arg Gln Asn His Glu Glu Ile Met Asp Ala Lys Pro 
                645                 650                 655     


Glu Leu Leu Ala Phe Gln Arg Pro Thr Ile Pro Arg Asn Pro Lys Gly 
            660                 665                 670         


Phe Gly Tyr Val Thr Phe Met His Leu Glu Ala Leu Arg Gln Arg Thr 
        675                 680                 685             


Phe Ile Lys Asp Asp Thr Leu Leu Val Arg Cys Glu Val Ser Thr Arg 
    690                 695                 700                 


Phe Asp Met Gly Ser Leu Arg Arg Glu Gly Phe Gln Pro Arg Ser Thr 
705                 710                 715                 720 


Asp Ala Gly Val 
                


<210> 609
<211> 702
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 609
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                165                 170                 175     


Arg Leu Leu His Ser Ser Leu Leu Asn Cys Glu Asn Ser Cys Gly Ser 
            180                 185                 190         


Ser Gln Ser Glu Ser Asp Cys Cys Val Ala Met Ala Ser Ser Cys Ser 
        195                 200                 205             


Ala Val Thr Lys Asp Asp Ser Val Gly Gly Thr Ala Ser Thr Gly Asn 
    210                 215                 220                 


Leu Ser Ser Ser Phe Met Glu Glu Ile Gln Gly Tyr Asp Val Glu Phe 
225                 230                 235                 240 


Asp Pro Pro Leu Glu Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met Ala 
                245                 250                 255     


Leu Arg Glu Ala Val Gln Thr Pro Cys Gly His Arg Phe Cys Lys Ala 
            260                 265                 270         


Cys Ile Ile Lys Ser Ile Arg Asp Ala Gly His Lys Cys Pro Val Asp 
        275                 280                 285             


Asn Glu Ile Leu Leu Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys 
    290                 295                 300                 


Arg Glu Ile Leu Ser Leu Met Val Lys Cys Pro Asn Glu Gly Cys Leu 
305                 310                 315                 320 


His Lys Met Glu Leu Arg His Leu Glu Asp His Gln Ala His Cys Glu 
                325                 330                 335     


Phe Ala Leu Met Asp Cys Pro Gln Cys Gln Arg Pro Phe Gln Lys Phe 
            340                 345                 350         


His Ile Asn Ile His Ile Leu Lys Asp Cys Pro Arg Arg Gln Val Ser 
        355                 360                 365             


Cys Asp Asn Cys Ala Ala Ser Met Ala Phe Glu Asp Lys Glu Ile His 
    370                 375                 380                 


Asp Gln Asn Cys Pro Leu Ala Asn Val Ile Cys Glu Tyr Cys Asn Thr 
385                 390                 395                 400 


Ile Leu Ile Arg Glu Gln Met Pro Asn His Tyr Asp Leu Asp Cys Pro 
                405                 410                 415     


Thr Ala Pro Ile Pro Cys Thr Phe Ser Thr Phe Gly Cys His Glu Lys 
            420                 425                 430         


Met Gln Arg Asn His Leu Ala Arg His Leu Gln Glu Asn Thr Gln Ser 
        435                 440                 445             


His Met Arg Met Leu Ala Gln Ala Val His Ser Leu Ser Val Ile Pro 
    450                 455                 460                 


Asp Ser Gly Tyr Ile Ser Glu Val Arg Asn Phe Gln Glu Thr Ile His 
465                 470                 475                 480 


Gln Leu Glu Gly Arg Leu Val Arg Gln Asp His Gln Ile Arg Glu Leu 
                485                 490                 495     


Thr Ala Lys Met Glu Thr Gln Ser Met Tyr Val Ser Glu Leu Lys Arg 
            500                 505                 510         


Thr Ile Arg Thr Leu Glu Asp Lys Val Ala Glu Ile Glu Ala Gln Gln 
        515                 520                 525             


Cys Asn Gly Ile Tyr Ile Trp Lys Ile Gly Asn Phe Gly Met His Leu 
    530                 535                 540                 


Lys Cys Gln Glu Glu Glu Lys Pro Val Val Ile His Ser Pro Gly Phe 
545                 550                 555                 560 


Tyr Thr Gly Lys Pro Gly Tyr Lys Leu Cys Met Arg Leu His Leu Gln 
                565                 570                 575     


Leu Pro Thr Ala Gln Arg Cys Ala Asn Tyr Ile Ser Leu Phe Val His 
            580                 585                 590         


Thr Met Gln Gly Glu Tyr Asp Ser His Leu Pro Trp Pro Phe Gln Gly 
        595                 600                 605             


Thr Ile Arg Leu Thr Ile Leu Asp Gln Ser Glu Ala Pro Val Arg Gln 
    610                 615                 620                 


Asn His Glu Glu Ile Met Asp Ala Lys Pro Glu Leu Leu Ala Phe Gln 
625                 630                 635                 640 


Arg Pro Thr Ile Pro Arg Asn Pro Lys Gly Phe Gly Tyr Val Thr Phe 
                645                 650                 655     


Met His Leu Glu Ala Leu Arg Gln Arg Thr Phe Ile Lys Asp Asp Thr 
            660                 665                 670         


Leu Leu Val Arg Cys Glu Val Ser Thr Arg Phe Asp Met Gly Ser Leu 
        675                 680                 685             


Arg Arg Glu Gly Phe Gln Pro Arg Ser Thr Asp Ala Gly Val 
    690                 695                 700         


<210> 610
<211> 423
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 610
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Ala Ser Ser Thr Ser 
        195                 200                 205             


Leu Pro Ala Pro Gly Ser Arg Pro Lys Lys Pro Leu Gly Lys Met Ala 
    210                 215                 220                 


Asp Trp Phe Arg Gln Thr Leu Leu Lys Lys Pro Lys Lys Arg Pro Asn 
225                 230                 235                 240 


Ser Pro Glu Ser Thr Ser Ser Asp Ala Ser Gln Pro Thr Ser Gln Asp 
                245                 250                 255     


Ser Pro Leu Pro Pro Ser Leu Ser Ser Val Thr Ser Pro Ser Leu Pro 
            260                 265                 270         


Pro Thr His Ala Ser Asp Ser Gly Ser Ser Arg Trp Ser Lys Asp Tyr 
        275                 280                 285             


Asp Val Cys Val Cys His Ser Glu Glu Asp Leu Val Ala Ala Gln Asp 
    290                 295                 300                 


Leu Val Ser Tyr Leu Glu Gly Ser Thr Ala Ser Leu Arg Cys Phe Leu 
305                 310                 315                 320 


Gln Leu Arg Asp Ala Thr Pro Gly Gly Ala Ile Val Ser Glu Leu Cys 
                325                 330                 335     


Gln Ala Leu Ser Ser Ser His Cys Arg Val Leu Leu Ile Thr Pro Gly 
            340                 345                 350         


Phe Leu Gln Asp Pro Trp Cys Lys Tyr Gln Met Leu Gln Ala Leu Thr 
        355                 360                 365             


Glu Ala Pro Gly Ala Glu Gly Cys Thr Ile Pro Leu Leu Ser Gly Leu 
    370                 375                 380                 


Ser Arg Ala Ala Tyr Pro Pro Glu Leu Arg Phe Met Tyr Tyr Val Asp 
385                 390                 395                 400 


Gly Arg Gly Pro Asp Gly Gly Phe Arg Gln Val Lys Glu Ala Val Met 
                405                 410                 415     


Arg Tyr Leu Gln Thr Leu Ser 
            420             


<210> 611
<211> 401
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 611
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                165                 170                 175     


Arg Leu Leu His Ser Ala Ser Ser Thr Ser Leu Pro Ala Pro Gly Ser 
            180                 185                 190         


Arg Pro Lys Lys Pro Leu Gly Lys Met Ala Asp Trp Phe Arg Gln Thr 
        195                 200                 205             


Leu Leu Lys Lys Pro Lys Lys Arg Pro Asn Ser Pro Glu Ser Thr Ser 
    210                 215                 220                 


Ser Asp Ala Ser Gln Pro Thr Ser Gln Asp Ser Pro Leu Pro Pro Ser 
225                 230                 235                 240 


Leu Ser Ser Val Thr Ser Pro Ser Leu Pro Pro Thr His Ala Ser Asp 
                245                 250                 255     


Ser Gly Ser Ser Arg Trp Ser Lys Asp Tyr Asp Val Cys Val Cys His 
            260                 265                 270         


Ser Glu Glu Asp Leu Val Ala Ala Gln Asp Leu Val Ser Tyr Leu Glu 
        275                 280                 285             


Gly Ser Thr Ala Ser Leu Arg Cys Phe Leu Gln Leu Arg Asp Ala Thr 
    290                 295                 300                 


Pro Gly Gly Ala Ile Val Ser Glu Leu Cys Gln Ala Leu Ser Ser Ser 
305                 310                 315                 320 


His Cys Arg Val Leu Leu Ile Thr Pro Gly Phe Leu Gln Asp Pro Trp 
                325                 330                 335     


Cys Lys Tyr Gln Met Leu Gln Ala Leu Thr Glu Ala Pro Gly Ala Glu 
            340                 345                 350         


Gly Cys Thr Ile Pro Leu Leu Ser Gly Leu Ser Arg Ala Ala Tyr Pro 
        355                 360                 365             


Pro Glu Leu Arg Phe Met Tyr Tyr Val Asp Gly Arg Gly Pro Asp Gly 
    370                 375                 380                 


Gly Phe Arg Gln Val Lys Glu Ala Val Met Arg Tyr Leu Gln Thr Leu 
385                 390                 395                 400 


Ser 
    


<210> 612
<211> 658
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 612
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Lys Leu Asn Lys 
        195                 200                 205             


Ile Thr Val Pro Ala Ser Gln Lys Leu Arg Gln Leu Gln Lys Met Val 
    210                 215                 220                 


His Asp Ile Lys Asn Asn Glu Gly Gly Ile Met Asn Lys Ile Lys Lys 
225                 230                 235                 240 


Leu Lys Val Lys Ala Pro Pro Ser Val Pro Arg Arg Asp Tyr Ala Ser 
                245                 250                 255     


Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp Ser Asp Asp Phe Asp Ser 
            260                 265                 270         


Asp Tyr Glu Asn Pro Asp Glu His Ser Asp Ser Glu Met Tyr Val Met 
        275                 280                 285             


Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr Glu Pro Pro Pro Val Glu 
    290                 295                 300                 


Gln Glu Thr Arg Pro Val His Pro Ala Leu Pro Phe Ala Arg Gly Glu 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Ser Ser Gln Arg His Ser Pro Pro Phe Ser Lys 
                325                 330                 335     


Thr Leu Pro Ser Lys Pro Ser Trp Pro Ser Glu Lys Ala Arg Leu Thr 
            340                 345                 350         


Ser Thr Leu Pro Ala Leu Thr Ala Leu Gln Lys Pro Gln Val Pro Pro 
        355                 360                 365             


Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala Asp Tyr Val Val Pro Val 
    370                 375                 380                 


Glu Asp Asn Asp Glu Asn Tyr Ile His Pro Thr Glu Ser Ser Ser Pro 
385                 390                 395                 400 


Pro Pro Glu Lys Ala Pro Met Val Asn Arg Ser Thr Lys Pro Asn Ser 
                405                 410                 415     


Ser Thr Pro Ala Ser Pro Pro Gly Thr Ala Ser Gly Arg Asn Ser Gly 
            420                 425                 430         


Ala Trp Glu Thr Lys Ser Pro Pro Pro Ala Ala Pro Ser Pro Leu Pro 
        435                 440                 445             


Arg Ala Gly Lys Lys Pro Thr Thr Pro Leu Lys Thr Thr Pro Val Ala 
    450                 455                 460                 


Ser Gln Gln Asn Ala Ser Ser Val Cys Glu Glu Lys Pro Ile Pro Ala 
465                 470                 475                 480 


Glu Arg His Arg Gly Ser Ser His Arg Gln Glu Ala Val Gln Ser Pro 
                485                 490                 495     


Val Phe Pro Pro Ala Gln Lys Gln Ile His Gln Lys Pro Ile Pro Leu 
            500                 505                 510         


Pro Arg Phe Thr Glu Gly Gly Asn Pro Thr Val Asp Gly Pro Leu Pro 
        515                 520                 525             


Ser Phe Ser Ser Asn Ser Thr Ile Ser Glu Gln Glu Ala Gly Val Leu 
    530                 535                 540                 


Cys Lys Pro Trp Tyr Ala Gly Ala Cys Asp Arg Lys Ser Ala Glu Glu 
545                 550                 555                 560 


Ala Leu His Arg Ser Asn Lys Asp Gly Ser Phe Leu Ile Arg Lys Ser 
                565                 570                 575     


Ser Gly His Asp Ser Lys Gln Pro Tyr Thr Leu Val Val Phe Phe Asn 
            580                 585                 590         


Lys Arg Val Tyr Asn Ile Pro Val Arg Phe Ile Glu Ala Thr Lys Gln 
        595                 600                 605             


Tyr Ala Leu Gly Arg Lys Lys Asn Gly Glu Glu Tyr Phe Gly Ser Val 
    610                 615                 620                 


Ala Glu Ile Ile Arg Asn His Gln His Ser Pro Leu Val Leu Ile Asp 
625                 630                 635                 640 


Ser Gln Asn Asn Thr Lys Asp Ser Thr Arg Leu Lys Tyr Ala Val Lys 
                645                 650                 655     


Val Ser 
        


<210> 613
<211> 636
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 613
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                165                 170                 175     


Arg Leu Leu His Ser Asp Lys Leu Asn Lys Ile Thr Val Pro Ala Ser 
            180                 185                 190         


Gln Lys Leu Arg Gln Leu Gln Lys Met Val His Asp Ile Lys Asn Asn 
        195                 200                 205             


Glu Gly Gly Ile Met Asn Lys Ile Lys Lys Leu Lys Val Lys Ala Pro 
    210                 215                 220                 


Pro Ser Val Pro Arg Arg Asp Tyr Ala Ser Glu Ser Pro Ala Asp Glu 
225                 230                 235                 240 


Glu Glu Gln Trp Ser Asp Asp Phe Asp Ser Asp Tyr Glu Asn Pro Asp 
                245                 250                 255     


Glu His Ser Asp Ser Glu Met Tyr Val Met Pro Ala Glu Glu Asn Ala 
            260                 265                 270         


Asp Asp Ser Tyr Glu Pro Pro Pro Val Glu Gln Glu Thr Arg Pro Val 
        275                 280                 285             


His Pro Ala Leu Pro Phe Ala Arg Gly Glu Tyr Ile Asp Asn Arg Ser 
    290                 295                 300                 


Ser Gln Arg His Ser Pro Pro Phe Ser Lys Thr Leu Pro Ser Lys Pro 
305                 310                 315                 320 


Ser Trp Pro Ser Glu Lys Ala Arg Leu Thr Ser Thr Leu Pro Ala Leu 
                325                 330                 335     


Thr Ala Leu Gln Lys Pro Gln Val Pro Pro Lys Pro Lys Gly Leu Leu 
            340                 345                 350         


Glu Asp Glu Ala Asp Tyr Val Val Pro Val Glu Asp Asn Asp Glu Asn 
        355                 360                 365             


Tyr Ile His Pro Thr Glu Ser Ser Ser Pro Pro Pro Glu Lys Ala Pro 
    370                 375                 380                 


Met Val Asn Arg Ser Thr Lys Pro Asn Ser Ser Thr Pro Ala Ser Pro 
385                 390                 395                 400 


Pro Gly Thr Ala Ser Gly Arg Asn Ser Gly Ala Trp Glu Thr Lys Ser 
                405                 410                 415     


Pro Pro Pro Ala Ala Pro Ser Pro Leu Pro Arg Ala Gly Lys Lys Pro 
            420                 425                 430         


Thr Thr Pro Leu Lys Thr Thr Pro Val Ala Ser Gln Gln Asn Ala Ser 
        435                 440                 445             


Ser Val Cys Glu Glu Lys Pro Ile Pro Ala Glu Arg His Arg Gly Ser 
    450                 455                 460                 


Ser His Arg Gln Glu Ala Val Gln Ser Pro Val Phe Pro Pro Ala Gln 
465                 470                 475                 480 


Lys Gln Ile His Gln Lys Pro Ile Pro Leu Pro Arg Phe Thr Glu Gly 
                485                 490                 495     


Gly Asn Pro Thr Val Asp Gly Pro Leu Pro Ser Phe Ser Ser Asn Ser 
            500                 505                 510         


Thr Ile Ser Glu Gln Glu Ala Gly Val Leu Cys Lys Pro Trp Tyr Ala 
        515                 520                 525             


Gly Ala Cys Asp Arg Lys Ser Ala Glu Glu Ala Leu His Arg Ser Asn 
    530                 535                 540                 


Lys Asp Gly Ser Phe Leu Ile Arg Lys Ser Ser Gly His Asp Ser Lys 
545                 550                 555                 560 


Gln Pro Tyr Thr Leu Val Val Phe Phe Asn Lys Arg Val Tyr Asn Ile 
                565                 570                 575     


Pro Val Arg Phe Ile Glu Ala Thr Lys Gln Tyr Ala Leu Gly Arg Lys 
            580                 585                 590         


Lys Asn Gly Glu Glu Tyr Phe Gly Ser Val Ala Glu Ile Ile Arg Asn 
        595                 600                 605             


His Gln His Ser Pro Leu Val Leu Ile Asp Ser Gln Asn Asn Thr Lys 
    610                 615                 620                 


Asp Ser Thr Arg Leu Lys Tyr Ala Val Lys Val Ser 
625                 630                 635     


<210> 614
<211> 419
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 614
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Glu Ala Ile Ala Lys 
        195                 200                 205             


Tyr Asp Phe Lys Ala Thr Ala Asp Asp Glu Leu Ser Phe Lys Arg Gly 
    210                 215                 220                 


Asp Ile Leu Lys Val Leu Asn Glu Glu Cys Asp Gln Asn Trp Tyr Lys 
225                 230                 235                 240 


Ala Glu Leu Asn Gly Lys Asp Gly Phe Ile Pro Lys Asn Tyr Ile Glu 
                245                 250                 255     


Met Lys Pro His Pro Trp Phe Phe Gly Lys Ile Pro Arg Ala Lys Ala 
            260                 265                 270         


Glu Glu Met Leu Ser Lys Gln Arg His Asp Gly Ala Phe Leu Ile Arg 
        275                 280                 285             


Glu Ser Glu Ser Ala Pro Gly Asp Phe Ser Leu Ser Val Lys Phe Gly 
    290                 295                 300                 


Asn Asp Val Gln His Phe Lys Val Leu Arg Asp Gly Ala Gly Lys Tyr 
305                 310                 315                 320 


Phe Leu Trp Val Val Lys Phe Asn Ser Leu Asn Glu Leu Val Asp Tyr 
                325                 330                 335     


His Arg Ser Thr Ser Val Ser Arg Asn Gln Gln Ile Phe Leu Arg Asp 
            340                 345                 350         


Ile Glu Gln Val Pro Gln Gln Pro Thr Tyr Val Gln Ala Leu Phe Asp 
        355                 360                 365             


Phe Asp Pro Gln Glu Asp Gly Glu Leu Gly Phe Arg Arg Gly Asp Phe 
    370                 375                 380                 


Ile His Val Met Asp Asn Ser Asp Pro Asn Trp Trp Lys Gly Ala Cys 
385                 390                 395                 400 


His Gly Gln Thr Gly Met Phe Pro Arg Asn Tyr Val Thr Pro Val Asn 
                405                 410                 415     


Arg Asn Val 
            


<210> 615
<211> 397
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 615
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                165                 170                 175     


Arg Leu Leu His Ser Glu Ala Ile Ala Lys Tyr Asp Phe Lys Ala Thr 
            180                 185                 190         


Ala Asp Asp Glu Leu Ser Phe Lys Arg Gly Asp Ile Leu Lys Val Leu 
        195                 200                 205             


Asn Glu Glu Cys Asp Gln Asn Trp Tyr Lys Ala Glu Leu Asn Gly Lys 
    210                 215                 220                 


Asp Gly Phe Ile Pro Lys Asn Tyr Ile Glu Met Lys Pro His Pro Trp 
225                 230                 235                 240 


Phe Phe Gly Lys Ile Pro Arg Ala Lys Ala Glu Glu Met Leu Ser Lys 
                245                 250                 255     


Gln Arg His Asp Gly Ala Phe Leu Ile Arg Glu Ser Glu Ser Ala Pro 
            260                 265                 270         


Gly Asp Phe Ser Leu Ser Val Lys Phe Gly Asn Asp Val Gln His Phe 
        275                 280                 285             


Lys Val Leu Arg Asp Gly Ala Gly Lys Tyr Phe Leu Trp Val Val Lys 
    290                 295                 300                 


Phe Asn Ser Leu Asn Glu Leu Val Asp Tyr His Arg Ser Thr Ser Val 
305                 310                 315                 320 


Ser Arg Asn Gln Gln Ile Phe Leu Arg Asp Ile Glu Gln Val Pro Gln 
                325                 330                 335     


Gln Pro Thr Tyr Val Gln Ala Leu Phe Asp Phe Asp Pro Gln Glu Asp 
            340                 345                 350         


Gly Glu Leu Gly Phe Arg Arg Gly Asp Phe Ile His Val Met Asp Asn 
        355                 360                 365             


Ser Asp Pro Asn Trp Trp Lys Gly Ala Cys His Gly Gln Thr Gly Met 
    370                 375                 380                 


Phe Pro Arg Asn Tyr Val Thr Pro Val Asn Arg Asn Val 
385                 390                 395         


<210> 616
<211> 266
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 616
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Ile Ile Val Ala Val Val Ile Ala Thr Ala 
                165                 170                 175     


Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr Cys Arg Lys 
            180                 185                 190         


Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala Ala Gln Phe 
        195                 200                 205             


Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg Gln Leu Glu 
    210                 215                 220                 


Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr Met Thr Leu 
225                 230                 235                 240 


Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr Leu Thr Leu 
                245                 250                 255     


Pro Pro Asn Asp His Val Asn Ser Asn Asn 
            260                 265     


<210> 617
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 617
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Ile Ile Val Ala Val Val Ile Ala Thr Ala Val Ala Ala Ile Val Ala 
145                 150                 155                 160 


Ala Val Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser Ala Asn 
                165                 170                 175     


Ser Thr Asp Pro Val Lys Ala Ala Gln Phe Glu Pro Pro Gly Arg Gln 
            180                 185                 190         


Met Ile Ala Ile Arg Lys Arg Gln Leu Glu Glu Thr Asn Asn Asp Tyr 
        195                 200                 205             


Glu Thr Ala Asp Gly Gly Tyr Met Thr Leu Asn Pro Arg Ala Pro Thr 
    210                 215                 220                 


Asp Asp Asp Lys Asn Ile Tyr Leu Thr Leu Pro Pro Asn Asp His Val 
225                 230                 235                 240 


Asn Ser Asn Asn 
                


<210> 618
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 618
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Ser Phe Cys Leu Val Met Val Leu Leu 
                165                 170                 175     


Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg 
            180                 185                 190         


Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp 
        195                 200                 205             


Pro Gln Asp Lys 
    210         


<210> 619
<211> 190
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 619
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
145                 150                 155                 160 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
                165                 170                 175     


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
            180                 185                 190 


<210> 620
<211> 307
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 620
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Leu Val Ile Ile Val Ile Leu Ser Ala 
                165                 170                 175     


Leu Phe Leu Gly Thr Leu Ala Cys Phe Cys Val Trp Arg Arg Lys Arg 
            180                 185                 190         


Lys Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu Phe Leu Thr Ile Tyr 
        195                 200                 205             


Glu Asp Val Lys Asp Leu Lys Thr Arg Arg Asn His Glu Gln Glu Gln 
    210                 215                 220                 


Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser Met Ile Gln Ser Gln 
225                 230                 235                 240 


Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr Thr Leu Tyr Ser Leu 
                245                 250                 255     


Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg Asn His Ser Pro 
            260                 265                 270         


Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys 
        275                 280                 285             


Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp 
    290                 295                 300                 


Val Tyr Ser 
305         


<210> 621
<211> 285
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 621
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe Leu Gly Thr Leu 
145                 150                 155                 160 


Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu 
                165                 170                 175     


Thr Ser Pro Lys Glu Phe Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu 
            180                 185                 190         


Lys Thr Arg Arg Asn His Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly 
        195                 200                 205             


Ser Thr Ile Tyr Ser Met Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser 
    210                 215                 220                 


Gln Glu Pro Ala Tyr Thr Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys 
225                 230                 235                 240 


Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser Phe Asn Ser Thr Ile 
                245                 250                 255     


Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg 
            260                 265                 270         


Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val Tyr Ser 
        275                 280                 285 


<210> 622
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 622
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Trp Ala Val Tyr Ala Gly Leu Leu Gly Gly 
                165                 170                 175     


Val Ile Met Ile Leu Ile Met Val Val Ile Leu Gln Leu Arg Arg Arg 
            180                 185                 190         


Gly Lys Thr Asn His Tyr Gln Thr Thr Val Glu Lys Lys Ser Leu Thr 
        195                 200                 205             


Ile Tyr Ala Gln Val Gln Lys Pro Gly Pro Leu Gln Lys Lys Leu Asp 
    210                 215                 220                 


Ser Phe Pro Ala Gln Asp Pro Cys Thr Thr Ile Tyr Val Ala Ala Thr 
225                 230                 235                 240 


Glu Pro Val Pro Glu Ser Val Gln Glu Thr Asn Ser Ile Thr Val Tyr 
                245                 250                 255     


Ala Ser Val Thr Leu Pro Glu Ser 
            260                 


<210> 623
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 623
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Trp Ala Val Tyr Ala Gly Leu Leu Gly Gly Val Ile Met Ile Leu Ile 
145                 150                 155                 160 


Met Val Val Ile Leu Gln Leu Arg Arg Arg Gly Lys Thr Asn His Tyr 
                165                 170                 175     


Gln Thr Thr Val Glu Lys Lys Ser Leu Thr Ile Tyr Ala Gln Val Gln 
            180                 185                 190         


Lys Pro Gly Pro Leu Gln Lys Lys Leu Asp Ser Phe Pro Ala Gln Asp 
        195                 200                 205             


Pro Cys Thr Thr Ile Tyr Val Ala Ala Thr Glu Pro Val Pro Glu Ser 
    210                 215                 220                 


Val Gln Glu Thr Asn Ser Ile Thr Val Tyr Ala Ser Val Thr Leu Pro 
225                 230                 235                 240 


Glu Ser 
        


<210> 624
<211> 286
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 624
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Leu Leu Ser Val Leu Ala Met Phe Phe Leu 
                165                 170                 175     


Leu Val Leu Ile Leu Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg 
            180                 185                 190         


Arg Gln Gly Arg Ile Phe Pro Glu Gly Ser Cys Leu Asn Thr Phe Thr 
        195                 200                 205             


Lys Asn Pro Tyr Ala Ala Ser Lys Lys Thr Ile Tyr Thr Tyr Ile Met 
    210                 215                 220                 


Ala Ser Arg Asn Thr Gln Pro Ala Glu Ser Arg Ile Tyr Asp Glu Ile 
225                 230                 235                 240 


Leu Gln Ser Lys Val Leu Pro Ser Lys Glu Glu Pro Val Asn Thr Val 
                245                 250                 255     


Tyr Ser Glu Val Gln Phe Ala Asp Lys Met Gly Lys Ala Ser Thr Gln 
            260                 265                 270         


Asp Ser Lys Pro Pro Gly Thr Ser Ser Tyr Glu Ile Val Ile 
        275                 280                 285     


<210> 625
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 625
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu Ser 
145                 150                 155                 160 


Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Gly Arg Ile Phe 
                165                 170                 175     


Pro Glu Gly Ser Cys Leu Asn Thr Phe Thr Lys Asn Pro Tyr Ala Ala 
            180                 185                 190         


Ser Lys Lys Thr Ile Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr Gln 
        195                 200                 205             


Pro Ala Glu Ser Arg Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val Leu 
    210                 215                 220                 


Pro Ser Lys Glu Glu Pro Val Asn Thr Val Tyr Ser Glu Val Gln Phe 
225                 230                 235                 240 


Ala Asp Lys Met Gly Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro Gly 
                245                 250                 255     


Thr Ser Ser Tyr Glu Ile Val Ile 
            260                 


<210> 626
<211> 271
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 626
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Ile Leu Phe Met Val Ser Gly Ile Cys Ile 
                165                 170                 175     


Val Phe Gly Phe Ile Ile Leu Leu Leu Leu Val Leu Arg Lys Arg Arg 
            180                 185                 190         


Asp Ser Leu Ser Leu Ser Thr Gln Arg Thr Gln Gly Pro Ala Glu Ser 
        195                 200                 205             


Ala Arg Asn Leu Glu Tyr Val Ser Val Ser Pro Thr Asn Asn Thr Val 
    210                 215                 220                 


Tyr Ala Ser Val Thr His Ser Asn Arg Glu Thr Glu Ile Trp Thr Pro 
225                 230                 235                 240 


Arg Glu Asn Asp Thr Ile Thr Ile Tyr Ser Thr Ile Asn His Ser Lys 
                245                 250                 255     


Glu Ser Lys Pro Thr Phe Ser Arg Ala Thr Ala Leu Asp Asn Val 
            260                 265                 270     


<210> 627
<211> 249
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 627
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Ile Leu Phe Met Val Ser Gly Ile Cys Ile Val Phe Gly Phe Ile Ile 
145                 150                 155                 160 


Leu Leu Leu Leu Val Leu Arg Lys Arg Arg Asp Ser Leu Ser Leu Ser 
                165                 170                 175     


Thr Gln Arg Thr Gln Gly Pro Ala Glu Ser Ala Arg Asn Leu Glu Tyr 
            180                 185                 190         


Val Ser Val Ser Pro Thr Asn Asn Thr Val Tyr Ala Ser Val Thr His 
        195                 200                 205             


Ser Asn Arg Glu Thr Glu Ile Trp Thr Pro Arg Glu Asn Asp Thr Ile 
    210                 215                 220                 


Thr Ile Tyr Ser Thr Ile Asn His Ser Lys Glu Ser Lys Pro Thr Phe 
225                 230                 235                 240 


Ser Arg Ala Thr Ala Leu Asp Asn Val 
                245                 


<210> 628
<211> 275
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 628
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Leu Leu Cys Leu Leu Leu Val Pro Leu 
                165                 170                 175     


Leu Leu Ser Leu Phe Val Leu Gly Leu Phe Leu Trp Phe Leu Lys Arg 
            180                 185                 190         


Glu Arg Gln Glu Glu Tyr Ile Glu Glu Lys Lys Arg Val Asp Ile Cys 
        195                 200                 205             


Arg Glu Thr Pro Asn Ile Cys Pro His Ser Gly Glu Asn Thr Glu Tyr 
    210                 215                 220                 


Asp Thr Ile Pro His Thr Asn Arg Thr Ile Leu Lys Glu Asp Pro Ala 
225                 230                 235                 240 


Asn Thr Val Tyr Ser Thr Val Glu Ile Pro Lys Lys Met Glu Asn Pro 
                245                 250                 255     


His Ser Leu Leu Thr Met Pro Asp Thr Pro Arg Leu Phe Ala Tyr Glu 
            260                 265                 270         


Asn Val Ile 
        275 


<210> 629
<211> 253
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 629
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Val Leu Leu Cys Leu Leu Leu Val Pro Leu Leu Leu Ser Leu Phe Val 
145                 150                 155                 160 


Leu Gly Leu Phe Leu Trp Phe Leu Lys Arg Glu Arg Gln Glu Glu Tyr 
                165                 170                 175     


Ile Glu Glu Lys Lys Arg Val Asp Ile Cys Arg Glu Thr Pro Asn Ile 
            180                 185                 190         


Cys Pro His Ser Gly Glu Asn Thr Glu Tyr Asp Thr Ile Pro His Thr 
        195                 200                 205             


Asn Arg Thr Ile Leu Lys Glu Asp Pro Ala Asn Thr Val Tyr Ser Thr 
    210                 215                 220                 


Val Glu Ile Pro Lys Lys Met Glu Asn Pro His Ser Leu Leu Thr Met 
225                 230                 235                 240 


Pro Asp Thr Pro Arg Leu Phe Ala Tyr Glu Asn Val Ile 
                245                 250             


<210> 630
<211> 308
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 630
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly 
                165                 170                 175     


Gly Ser Leu Leu Met Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr 
            180                 185                 190         


Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr 
        195                 200                 205             


Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln 
    210                 215                 220                 


Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro 
                245                 250                 255     


Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro 
            260                 265                 270         


Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro 
        275                 280                 285             


Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser 
    290                 295                 300                 


Pro Ser Ser Asn 
305             


<210> 631
<211> 286
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 631
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val 
145                 150                 155                 160 


Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln Arg 
                165                 170                 175     


Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val Ala 
            180                 185                 190         


Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr Pro 
        195                 200                 205             


Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His Arg 
    210                 215                 220                 


Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val Gln 
225                 230                 235                 240 


His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val His 
                245                 250                 255     


Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys Pro 
            260                 265                 270         


Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn 
        275                 280                 285     


<210> 632
<211> 367
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 632
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Leu Trp Ile Gly Leu Phe Leu Met Val Cys 
                165                 170                 175     


Leu Leu Cys Val Gly Ile Phe Ser Trp Cys Ile Trp Lys Arg Lys Gly 
            180                 185                 190         


Arg Cys Ser Val Pro Ala Phe Cys Ser Ser Gln Ala Glu Ala Pro Ala 
        195                 200                 205             


Asp Thr Pro Glu Pro Thr Ala Gly His Thr Leu Tyr Ser Val Leu Ser 
    210                 215                 220                 


Gln Gly Tyr Glu Lys Leu Asp Thr Pro Leu Arg Pro Ala Arg Gln Gln 
225                 230                 235                 240 


Pro Thr Pro Thr Ser Asp Ser Ser Ser Asp Ser Asn Leu Thr Thr Glu 
                245                 250                 255     


Glu Asp Glu Asp Arg Pro Glu Val His Lys Pro Ile Ser Gly Arg Tyr 
            260                 265                 270         


Glu Val Phe Asp Gln Val Thr Gln Glu Gly Ala Gly His Asp Pro Ala 
        275                 280                 285             


Pro Glu Gly Gln Ala Asp Tyr Asp Pro Val Thr Pro Tyr Val Thr Glu 
    290                 295                 300                 


Val Glu Ser Val Val Gly Glu Asn Thr Met Tyr Ala Gln Val Phe Asn 
305                 310                 315                 320 


Leu Gln Gly Lys Thr Pro Val Ser Gln Lys Glu Glu Ser Ser Ala Thr 
                325                 330                 335     


Ile Tyr Cys Ser Ile Arg Lys Pro Gln Val Val Pro Pro Pro Gln Gln 
            340                 345                 350         


Asn Asp Leu Glu Ile Pro Glu Ser Pro Thr Tyr Glu Asn Phe Thr 
        355                 360                 365         


<210> 633
<211> 345
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 633
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Leu Trp Ile Gly Leu Phe Leu Met Val Cys Leu Leu Cys Val Gly Ile 
145                 150                 155                 160 


Phe Ser Trp Cys Ile Trp Lys Arg Lys Gly Arg Cys Ser Val Pro Ala 
                165                 170                 175     


Phe Cys Ser Ser Gln Ala Glu Ala Pro Ala Asp Thr Pro Glu Pro Thr 
            180                 185                 190         


Ala Gly His Thr Leu Tyr Ser Val Leu Ser Gln Gly Tyr Glu Lys Leu 
        195                 200                 205             


Asp Thr Pro Leu Arg Pro Ala Arg Gln Gln Pro Thr Pro Thr Ser Asp 
    210                 215                 220                 


Ser Ser Ser Asp Ser Asn Leu Thr Thr Glu Glu Asp Glu Asp Arg Pro 
225                 230                 235                 240 


Glu Val His Lys Pro Ile Ser Gly Arg Tyr Glu Val Phe Asp Gln Val 
                245                 250                 255     


Thr Gln Glu Gly Ala Gly His Asp Pro Ala Pro Glu Gly Gln Ala Asp 
            260                 265                 270         


Tyr Asp Pro Val Thr Pro Tyr Val Thr Glu Val Glu Ser Val Val Gly 
        275                 280                 285             


Glu Asn Thr Met Tyr Ala Gln Val Phe Asn Leu Gln Gly Lys Thr Pro 
    290                 295                 300                 


Val Ser Gln Lys Glu Glu Ser Ser Ala Thr Ile Tyr Cys Ser Ile Arg 
305                 310                 315                 320 


Lys Pro Gln Val Val Pro Pro Pro Gln Gln Asn Asp Leu Glu Ile Pro 
                325                 330                 335     


Glu Ser Pro Thr Tyr Glu Asn Phe Thr 
            340                 345 


<210> 634
<211> 424
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 634
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Leu Ile Leu Thr Leu Ser Leu Ile Leu Val 
                165                 170                 175     


Val Ile Leu Val Leu Leu Thr Val Leu Ala Leu Leu Ser His Arg Arg 
            180                 185                 190         


Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro Glu Ser Glu 
        195                 200                 205             


Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln Leu Trp Leu 
    210                 215                 220                 


Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr Pro Phe Thr 
225                 230                 235                 240 


Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg Cys Trp Gly 
                245                 250                 255     


Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu Gly Pro Leu Leu 
            260                 265                 270         


Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr Leu Val Leu Asp 
        275                 280                 285             


Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp Leu Pro Gly Pro 
    290                 295                 300                 


Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly Ser Glu Ala Ser 
305                 310                 315                 320 


Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro Glu Gly Ala Ser 
                325                 330                 335     


Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser Ser Gln Leu Leu 
            340                 345                 350         


Arg Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr Pro Pro His Leu 
        355                 360                 365             


Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile Ser Thr Asp Tyr 
    370                 375                 380                 


Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu Ser Asp Gly Pro 
385                 390                 395                 400 


Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala Ala Glu Pro Leu 
                405                 410                 415     


Pro Pro Ser Tyr Val Ala Cys Ser 
            420                 


<210> 635
<211> 402
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 635
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Leu Ile Leu Thr Leu Ser Leu Ile Leu Val Val Ile Leu Val Leu Leu 
145                 150                 155                 160 


Thr Val Leu Ala Leu Leu Ser His Arg Arg Ala Leu Lys Gln Lys Ile 
                165                 170                 175     


Trp Pro Gly Ile Pro Ser Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr 
            180                 185                 190         


Thr His Lys Gly Asn Phe Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys 
        195                 200                 205             


Leu Trp Trp Ser Pro Cys Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser 
    210                 215                 220                 


Leu Glu Val Leu Ser Glu Arg Cys Trp Gly Thr Met Gln Ala Val Glu 
225                 230                 235                 240 


Pro Gly Thr Asp Asp Glu Gly Pro Leu Leu Glu Pro Val Gly Ser Glu 
                245                 250                 255     


His Ala Gln Asp Thr Tyr Leu Val Leu Asp Lys Trp Leu Leu Pro Arg 
            260                 265                 270         


Asn Pro Pro Ser Glu Asp Leu Pro Gly Pro Gly Gly Ser Val Asp Ile 
        275                 280                 285             


Val Ala Met Asp Glu Gly Ser Glu Ala Ser Ser Cys Ser Ser Ala Leu 
    290                 295                 300                 


Ala Ser Lys Pro Ser Pro Glu Gly Ala Ser Ala Ala Ser Phe Glu Tyr 
305                 310                 315                 320 


Thr Ile Leu Asp Pro Ser Ser Gln Leu Leu Arg Pro Trp Thr Leu Cys 
                325                 330                 335     


Pro Glu Leu Pro Pro Thr Pro Pro His Leu Lys Tyr Leu Tyr Leu Val 
            340                 345                 350         


Val Ser Asp Ser Gly Ile Ser Thr Asp Tyr Ser Ser Gly Asp Ser Gln 
        355                 360                 365             


Gly Ala Gln Gly Gly Leu Ser Asp Gly Pro Tyr Ser Asn Pro Tyr Glu 
    370                 375                 380                 


Asn Ser Leu Ile Pro Ala Ala Glu Pro Leu Pro Pro Ser Tyr Val Ala 
385                 390                 395                 400 


Cys Ser 
        


<210> 636
<211> 375
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 636
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu 
                165                 170                 175     


Leu Leu Thr Cys Leu Cys Gly Thr Ala Trp Leu Cys Cys Ser Pro Asn 
            180                 185                 190         


Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala His Ser Ser 
        195                 200                 205             


Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala Phe Gln Leu 
    210                 215                 220                 


Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val Leu Glu Glu 
225                 230                 235                 240 


Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn Ser Ser Glu Thr 
                245                 250                 255     


Cys Gly Leu Pro Thr Leu Val Gln Thr Tyr Val Leu Gln Gly Asp Pro 
            260                 265                 270         


Arg Ala Val Ser Thr Gln Pro Gln Ser Gln Ser Gly Thr Ser Asp Gln 
        275                 280                 285             


Val Leu Tyr Gly Gln Leu Leu Gly Ser Pro Thr Ser Pro Gly Pro Gly 
    290                 295                 300                 


His Tyr Leu Arg Cys Asp Ser Thr Gln Pro Leu Leu Ala Gly Leu Thr 
305                 310                 315                 320 


Pro Ser Pro Lys Ser Tyr Glu Asn Leu Trp Phe Gln Ala Ser Pro Leu 
                325                 330                 335     


Gly Thr Leu Val Thr Pro Ala Pro Ser Gln Glu Asp Asp Cys Val Phe 
            340                 345                 350         


Gly Pro Leu Leu Asn Phe Pro Leu Leu Gln Gly Ile Arg Val His Gly 
        355                 360                 365             


Met Glu Ala Leu Gly Ser Phe 
    370                 375 


<210> 637
<211> 353
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 637
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr Cys Leu Cys 
145                 150                 155                 160 


Gly Thr Ala Trp Leu Cys Cys Ser Pro Asn Arg Lys Asn Pro Leu Trp 
                165                 170                 175     


Pro Ser Val Pro Asp Pro Ala His Ser Ser Leu Gly Ser Trp Val Pro 
            180                 185                 190         


Thr Ile Met Glu Glu Asp Ala Phe Gln Leu Pro Gly Leu Gly Thr Pro 
        195                 200                 205             


Pro Ile Thr Lys Leu Thr Val Leu Glu Glu Asp Glu Lys Lys Pro Val 
    210                 215                 220                 


Pro Trp Glu Ser His Asn Ser Ser Glu Thr Cys Gly Leu Pro Thr Leu 
225                 230                 235                 240 


Val Gln Thr Tyr Val Leu Gln Gly Asp Pro Arg Ala Val Ser Thr Gln 
                245                 250                 255     


Pro Gln Ser Gln Ser Gly Thr Ser Asp Gln Val Leu Tyr Gly Gln Leu 
            260                 265                 270         


Leu Gly Ser Pro Thr Ser Pro Gly Pro Gly His Tyr Leu Arg Cys Asp 
        275                 280                 285             


Ser Thr Gln Pro Leu Leu Ala Gly Leu Thr Pro Ser Pro Lys Ser Tyr 
    290                 295                 300                 


Glu Asn Leu Trp Phe Gln Ala Ser Pro Leu Gly Thr Leu Val Thr Pro 
305                 310                 315                 320 


Ala Pro Ser Gln Glu Asp Asp Cys Val Phe Gly Pro Leu Leu Asn Phe 
                325                 330                 335     


Pro Leu Leu Gln Gly Ile Arg Val His Gly Met Glu Ala Leu Gly Ser 
            340                 345                 350         


Phe 
    


<210> 638
<211> 621
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 638
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Val Val Ala Cys Met Ser Ile Met Ala 
                165                 170                 175     


Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys 
            180                 185                 190         


Pro Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn 
        195                 200                 205             


Ser Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp 
    210                 215                 220                 


Glu Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly 
225                 230                 235                 240 


Ala Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu 
                245                 250                 255     


Asp Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His 
            260                 265                 270         


Ala Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His 
        275                 280                 285             


Leu Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His 
    290                 295                 300                 


Gly Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu 
305                 310                 315                 320 


Leu Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu 
                325                 330                 335     


Ser Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His 
            340                 345                 350         


Leu Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly 
        355                 360                 365             


Val Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp 
    370                 375                 380                 


Ser Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu 
385                 390                 395                 400 


Leu Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala 
                405                 410                 415     


Phe Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn 
            420                 425                 430         


Val Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu 
        435                 440                 445             


Ala Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala 
    450                 455                 460                 


Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val 
465                 470                 475                 480 


Tyr Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu 
                485                 490                 495     


Ile Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser 
            500                 505                 510         


Lys Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala 
        515                 520                 525             


Phe Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu 
    530                 535                 540                 


Glu Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln 
545                 550                 555                 560 


Glu Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro 
                565                 570                 575     


Ser Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu 
            580                 585                 590         


Glu Glu Ser Ser Ser Glu His Leu Thr Cys Cys Glu Gln Gly Asp Ile 
        595                 600                 605             


Ala Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys 
    610                 615                 620     


<210> 639
<211> 599
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 639
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Val Val Val Ala Cys Met Ser Ile Met Ala Leu Leu Leu Leu Leu Leu 
145                 150                 155                 160 


Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro Lys Tyr Gln Val Arg 
                165                 170                 175     


Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser Tyr Thr Phe Ile Asp 
            180                 185                 190         


Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu Phe Pro Arg Asn Asn 
        195                 200                 205             


Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val 
    210                 215                 220                 


Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp Ala Val Leu Lys Val 
225                 230                 235                 240 


Ala Val Lys Met Leu Lys Ser Thr Ala His Ala Asp Glu Lys Glu Ala 
                245                 250                 255     


Leu Met Ser Glu Leu Lys Ile Met Ser His Leu Gly Gln His Glu Asn 
            260                 265                 270         


Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly Gly Pro Val Leu Val 
        275                 280                 285             


Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg 
    290                 295                 300                 


Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser Pro Gly Gln Asp Pro 
305                 310                 315                 320 


Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu Glu Lys Lys Tyr Val 
                325                 330                 335     


Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val Asp Thr Tyr Val Glu 
            340                 345                 350         


Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser Phe Ser Glu Gln Asp 
        355                 360                 365             


Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu Arg Asp Leu Leu His 
    370                 375                 380                 


Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe Leu Ala Ser Lys Asn 
385                 390                 395                 400 


Cys Ile His Arg Asp Val Ala Ala Arg Asn Val Leu Leu Thr Asn Gly 
                405                 410                 415     


His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala Arg Asp Ile Met Asn 
            420                 425                 430         


Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg Leu Pro Val Lys Trp 
        435                 440                 445             


Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr Thr Val Gln Ser Asp 
    450                 455                 460                 


Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Leu 
465                 470                 475                 480 


Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys Phe Tyr Lys Leu Val 
                485                 490                 495     


Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe Ala Pro Lys Asn Ile 
            500                 505                 510         


Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu Pro Thr His Arg Pro 
        515                 520                 525             


Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu Gln Ala Gln Glu Asp 
    530                 535                 540                 


Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser Ser Ser Arg Ser Gly 
545                 550                 555                 560 


Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu Glu Ser Ser Ser Glu 
                565                 570                 575     


His Leu Thr Cys Cys Glu Gln Gly Asp Ile Ala Gln Pro Leu Leu Gln 
            580                 585                 590         


Pro Asn Asn Tyr Gln Phe Cys 
        595                 


<210> 640
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 640
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Ile Ile Ile Tyr Cys Thr Gly Ala Phe Leu 
                165                 170                 175     


Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys Ser Gly 
            180                 185                 190         


Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys Leu Ala 
        195                 200                 205             


Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp Ser Ser 
    210                 215                 220                 


Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser 
225                 230                 235                 240 


Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro 
                245                 250                 255     


Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys 
            260                 265                 270         


Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile 
        275                 280                 285             


Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala Val Lys 
    290                 295                 300                 


Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser 
305                 310                 315                 320 


Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
                325                 330                 335     


Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu 
            340                 345                 350         


Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro 
        355                 360                 365             


Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu Glu Gln 
    370                 375                 380                 


Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly 
385                 390                 395                 400 


Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala 
                405                 410                 415     


Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe 
            420                 425                 430         


Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr 
        435                 440                 445             


Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
    450                 455                 460                 


Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
465                 470                 475                 480 


Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val 
                485                 490                 495     


Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
            500                 505                 510         


Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His 
        515                 520                 525             


Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
    530                 535                 540                 


Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser 
545                 550                 555                 560 


Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser 
                565                 570                 575     


Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro 
            580                 585                 590         


Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn Gly Gly 
        595                 600                 605             


Leu Lys Arg Arg 
    610         


<210> 641
<211> 590
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 641
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Ile Ile Ile Tyr Cys Thr Gly Ala Phe Leu Ile Ser Cys Met Val Gly 
145                 150                 155                 160 


Ser Val Ile Val Tyr Lys Met Lys Ser Gly Thr Lys Lys Ser Asp Phe 
                165                 170                 175     


His Ser Gln Met Ala Val His Lys Leu Ala Lys Ser Ile Pro Leu Arg 
            180                 185                 190         


Arg Gln Val Thr Val Ser Ala Asp Ser Ser Ala Ser Met Asn Ser Gly 
        195                 200                 205             


Val Leu Leu Val Arg Pro Ser Arg Leu Ser Ser Ser Gly Thr Pro Met 
    210                 215                 220                 


Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu 
225                 230                 235                 240 


Leu Pro Arg Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys 
                245                 250                 255     


Phe Gly Gln Val Val Leu Ala Glu Ala Ile Gly Leu Asp Lys Asp Lys 
            260                 265                 270         


Pro Asn Arg Val Thr Lys Val Ala Val Lys Met Leu Lys Ser Asp Ala 
        275                 280                 285             


Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser Glu Met Glu Met Met Lys 
    290                 295                 300                 


Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr 
305                 310                 315                 320 


Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn 
                325                 330                 335     


Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro Pro Gly Leu Glu Tyr Cys 
            340                 345                 350         


Tyr Asn Pro Ser His Asn Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu 
        355                 360                 365             


Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser 
    370                 375                 380                 


Lys Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr 
385                 390                 395                 400 


Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile 
                405                 410                 415     


His His Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val 
            420                 425                 430         


Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Ile Tyr Thr His Gln 
        435                 440                 445             


Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu 
    450                 455                 460                 


Gly Gly Ser Pro Tyr Pro Gly Val Pro Val Glu Glu Leu Phe Lys Leu 
465                 470                 475                 480 


Leu Lys Glu Gly His Arg Met Asp Lys Pro Ser Asn Cys Thr Asn Glu 
                485                 490                 495     


Leu Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg 
            500                 505                 510         


Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Val Ala Leu 
        515                 520                 525             


Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser Met Pro Leu Asp Gln Tyr 
    530                 535                 540                 


Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser Thr Cys Ser Ser Gly Glu 
545                 550                 555                 560 


Asp Ser Val Phe Ser His Glu Pro Leu Pro Glu Glu Pro Cys Leu Pro 
                565                 570                 575     


Arg His Pro Ala Gln Leu Ala Asn Gly Gly Leu Lys Arg Arg 
            580                 585                 590 


<210> 642
<211> 248
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 642
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Gly Gly Thr Val Leu Leu Leu Leu Phe Val 
                165                 170                 175     


Ile Ser Ile Thr Thr Ile Ile Val Ile Phe Leu Asn Arg Arg Arg Arg 
            180                 185                 190         


Arg Glu Arg Arg Asp Leu Phe Thr Glu Ser Trp Asp Thr Gln Lys Ala 
        195                 200                 205             


Pro Asn Asn Tyr Arg Ser Pro Ile Ser Thr Ser Gln Pro Thr Asn Gln 
    210                 215                 220                 


Ser Met Asp Asp Thr Arg Glu Asp Ile Tyr Val Asn Tyr Pro Thr Phe 
225                 230                 235                 240 


Ser Arg Arg Pro Lys Thr Arg Val 
                245             


<210> 643
<211> 226
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 643
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Gly Gly Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile 
145                 150                 155                 160 


Ile Val Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu 
                165                 170                 175     


Phe Thr Glu Ser Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser 
            180                 185                 190         


Pro Ile Ser Thr Ser Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg 
        195                 200                 205             


Glu Asp Ile Tyr Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr 
    210                 215                 220                 


Arg Val 
225     


<210> 644
<211> 225
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 644
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe 
                165                 170                 175     


Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp Leu Thr Lys 
            180                 185                 190         


Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe 
        195                 200                 205             


Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr 
    210                 215                 220                 


Leu 
225 


<210> 645
<211> 203
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 645
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
145                 150                 155                 160 


Gly Cys Ile Leu Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser 
                165                 170                 175     


Val His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr 
            180                 185                 190         


Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu 
        195                 200             


<210> 646
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 646
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Met Gly Leu Ala Phe Leu Val Leu Val Ala 
                165                 170                 175     


Leu Val Trp Phe Leu Val Glu Asp Trp Leu Ser Arg Lys Arg Thr Arg 
            180                 185                 190         


Glu Arg Ala Ser Arg Ala Ser Thr Trp Glu Gly Arg Arg Arg Leu Asn 
        195                 200                 205             


Thr Gln Thr Leu 
    210         


<210> 647
<211> 190
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 647
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Met Gly Leu Ala Phe Leu Val Leu Val Ala Leu Val Trp Phe Leu Val 
145                 150                 155                 160 


Glu Asp Trp Leu Ser Arg Lys Arg Thr Arg Glu Arg Ala Ser Arg Ala 
                165                 170                 175     


Ser Thr Trp Glu Gly Arg Arg Arg Leu Asn Thr Gln Thr Leu 
            180                 185                 190 


<210> 648
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 648
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Leu Val Pro Val Phe Cys Gly Leu Leu Val 
                165                 170                 175     


Ala Lys Ser Leu Val Leu Ser Ala Leu Leu Val Trp Trp Gly Asp Ile 
            180                 185                 190         


Trp Trp Lys Thr Met Met Glu Leu Arg Ser Leu Asp Thr Gln Lys Ala 
        195                 200                 205             


Thr Cys His Leu Gln Gln Val Thr Asp Leu Pro Trp Thr Ser Val Ser 
    210                 215                 220                 


Ser Pro Val Glu Arg Glu Ile Leu Tyr His Thr Val Ala Arg Thr Lys 
225                 230                 235                 240 


Ile Ser Asp Asp Asp Asp Glu His Thr Leu 
                245                 250 


<210> 649
<211> 228
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 649
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Leu Val Pro Val Phe Cys Gly Leu Leu Val Ala Lys Ser Leu Val Leu 
145                 150                 155                 160 


Ser Ala Leu Leu Val Trp Trp Gly Asp Ile Trp Trp Lys Thr Met Met 
                165                 170                 175     


Glu Leu Arg Ser Leu Asp Thr Gln Lys Ala Thr Cys His Leu Gln Gln 
            180                 185                 190         


Val Thr Asp Leu Pro Trp Thr Ser Val Ser Ser Pro Val Glu Arg Glu 
        195                 200                 205             


Ile Leu Tyr His Thr Val Ala Arg Thr Lys Ile Ser Asp Asp Asp Asp 
    210                 215                 220                 


Glu His Thr Leu 
225             


<210> 650
<211> 232
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 650
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Ala Gly Thr Val Leu Leu Leu Arg Ala Gly 
                165                 170                 175     


Phe Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val Tyr 
            180                 185                 190         


Tyr Gln Gly Lys Cys Leu Thr Trp Lys Gly Pro Arg Arg Gln Leu Pro 
        195                 200                 205             


Ala Val Val Pro Ala Pro Leu Pro Pro Pro Cys Gly Ser Ser Ala His 
    210                 215                 220                 


Leu Leu Pro Pro Val Pro Gly Gly 
225                 230         


<210> 651
<211> 210
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 651
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Ala Gly Thr Val Leu Leu Leu Arg Ala Gly Phe Tyr Ala Val Ser Phe 
145                 150                 155                 160 


Leu Ser Val Ala Val Gly Ser Thr Val Tyr Tyr Gln Gly Lys Cys Leu 
                165                 170                 175     


Thr Trp Lys Gly Pro Arg Arg Gln Leu Pro Ala Val Val Pro Ala Pro 
            180                 185                 190         


Leu Pro Pro Pro Cys Gly Ser Ser Ala His Leu Leu Pro Pro Val Pro 
        195                 200                 205             


Gly Gly 
    210 


<210> 652
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 652
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asn Lys Pro Ile Thr 
        195                 200                 205             


Pro Ser Thr Tyr Val Arg Cys Leu Asn Val Gly Leu Ile Arg Lys Leu 
    210                 215                 220                 


Ser Asp Phe Ile Asp Pro Gln Glu Gly Trp Lys Lys Leu Ala Val Ala 
225                 230                 235                 240 


Ile Lys Lys Pro Ser Gly Asp Asp Arg Tyr Asn Gln Phe His Ile Arg 
                245                 250                 255     


Arg Phe Glu Ala Leu Leu Gln Thr Gly Lys Ser Pro Thr Ser Glu Leu 
            260                 265                 270         


Leu Phe Asp Trp Gly Thr Thr Asn Cys Thr Val Gly Asp Leu Val Asp 
        275                 280                 285             


Leu Leu Ile Gln Asn Glu Phe Phe Ala Pro Ala Ser Leu Leu Leu Pro 
    290                 295                 300                 


Asp Ala Val Pro Lys Thr Ala Asn Thr Leu Pro Ser Lys Glu Ala Ile 
305                 310                 315                 320 


Thr Val Gln Gln Lys Gln Met Pro Phe Cys Asp Lys Asp Arg Thr Leu 
                325                 330                 335     


Met Thr Pro Val Gln Asn Leu Glu Gln Ser Tyr Met Pro Pro Asp Ser 
            340                 345                 350         


Ser Ser Pro Glu Asn Lys Ser Leu Glu Val Ser Asp Thr Arg Phe His 
        355                 360                 365             


Ser Phe Ser Phe Tyr Glu Leu Lys Asn Val Thr Asn Asn Phe Asp Glu 
    370                 375                 380                 


Arg Pro Ile Ser Val Gly Gly Asn Lys Met Gly Glu Gly Gly Phe Gly 
385                 390                 395                 400 


Val Val Tyr Lys Gly Tyr Val Asn Asn Thr Thr Val Ala Val Lys Lys 
                405                 410                 415     


Leu Ala Ala Met Val Asp Ile Thr Thr Glu Glu Leu Lys Gln Gln Phe 
            420                 425                 430         


Asp Gln Glu Ile Lys Val Met Ala Lys Cys Gln His Glu Asn Leu Val 
        435                 440                 445             


Glu Leu Leu Gly Phe Ser Ser Asp Gly Asp Asp Leu Cys Leu Val Tyr 
    450                 455                 460                 


Val Tyr Met Pro Asn Gly Ser Leu Leu Asp Arg Leu Ser Cys Leu Asp 
465                 470                 475                 480 


Gly Thr Pro Pro Leu Ser Trp His Met Arg Cys Lys Ile Ala Gln Gly 
                485                 490                 495     


Ala Ala Asn Gly Ile Asn Phe Leu His Glu Asn His His Ile His Arg 
            500                 505                 510         


Asp Ile Lys Ser Ala Asn Ile Leu Leu Asp Glu Ala Phe Thr Ala Lys 
        515                 520                 525             


Ile Ser Asp Phe Gly Leu Ala Arg Ala Ser Glu Lys Phe Ala Gln Thr 
    530                 535                 540                 


Val Met Thr Ser Arg Ile Val Gly Thr Thr Ala Tyr Met Ala Pro Glu 
545                 550                 555                 560 


Ala Leu Arg Gly Glu Ile Thr Pro Lys Ser Asp Ile Tyr Ser Phe Gly 
                565                 570                 575     


Val Val Leu Leu Glu Ile Ile Thr Gly Leu Pro Ala Val Asp Glu His 
            580                 585                 590         


Arg Glu Pro Gln Leu Leu Leu Asp Ile Lys Glu Glu Ile Glu Asp Glu 
        595                 600                 605             


Glu Lys Thr Ile Glu Asp Tyr Ile Asp Lys Lys Met Asn Asp Ala Asp 
    610                 615                 620                 


Ser Thr Ser Val Glu Ala Met Tyr Ser Val Ala Ser Gln Cys Leu His 
625                 630                 635                 640 


Glu Lys Lys Asn Lys Arg Pro Asp Ile Lys Lys Val Gln Gln Leu Leu 
                645                 650                 655     


Gln Glu Met Thr Ala Ser 
            660         


<210> 653
<211> 640
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 653
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                165                 170                 175     


Arg Leu Leu His Ser Asn Lys Pro Ile Thr Pro Ser Thr Tyr Val Arg 
            180                 185                 190         


Cys Leu Asn Val Gly Leu Ile Arg Lys Leu Ser Asp Phe Ile Asp Pro 
        195                 200                 205             


Gln Glu Gly Trp Lys Lys Leu Ala Val Ala Ile Lys Lys Pro Ser Gly 
    210                 215                 220                 


Asp Asp Arg Tyr Asn Gln Phe His Ile Arg Arg Phe Glu Ala Leu Leu 
225                 230                 235                 240 


Gln Thr Gly Lys Ser Pro Thr Ser Glu Leu Leu Phe Asp Trp Gly Thr 
                245                 250                 255     


Thr Asn Cys Thr Val Gly Asp Leu Val Asp Leu Leu Ile Gln Asn Glu 
            260                 265                 270         


Phe Phe Ala Pro Ala Ser Leu Leu Leu Pro Asp Ala Val Pro Lys Thr 
        275                 280                 285             


Ala Asn Thr Leu Pro Ser Lys Glu Ala Ile Thr Val Gln Gln Lys Gln 
    290                 295                 300                 


Met Pro Phe Cys Asp Lys Asp Arg Thr Leu Met Thr Pro Val Gln Asn 
305                 310                 315                 320 


Leu Glu Gln Ser Tyr Met Pro Pro Asp Ser Ser Ser Pro Glu Asn Lys 
                325                 330                 335     


Ser Leu Glu Val Ser Asp Thr Arg Phe His Ser Phe Ser Phe Tyr Glu 
            340                 345                 350         


Leu Lys Asn Val Thr Asn Asn Phe Asp Glu Arg Pro Ile Ser Val Gly 
        355                 360                 365             


Gly Asn Lys Met Gly Glu Gly Gly Phe Gly Val Val Tyr Lys Gly Tyr 
    370                 375                 380                 


Val Asn Asn Thr Thr Val Ala Val Lys Lys Leu Ala Ala Met Val Asp 
385                 390                 395                 400 


Ile Thr Thr Glu Glu Leu Lys Gln Gln Phe Asp Gln Glu Ile Lys Val 
                405                 410                 415     


Met Ala Lys Cys Gln His Glu Asn Leu Val Glu Leu Leu Gly Phe Ser 
            420                 425                 430         


Ser Asp Gly Asp Asp Leu Cys Leu Val Tyr Val Tyr Met Pro Asn Gly 
        435                 440                 445             


Ser Leu Leu Asp Arg Leu Ser Cys Leu Asp Gly Thr Pro Pro Leu Ser 
    450                 455                 460                 


Trp His Met Arg Cys Lys Ile Ala Gln Gly Ala Ala Asn Gly Ile Asn 
465                 470                 475                 480 


Phe Leu His Glu Asn His His Ile His Arg Asp Ile Lys Ser Ala Asn 
                485                 490                 495     


Ile Leu Leu Asp Glu Ala Phe Thr Ala Lys Ile Ser Asp Phe Gly Leu 
            500                 505                 510         


Ala Arg Ala Ser Glu Lys Phe Ala Gln Thr Val Met Thr Ser Arg Ile 
        515                 520                 525             


Val Gly Thr Thr Ala Tyr Met Ala Pro Glu Ala Leu Arg Gly Glu Ile 
    530                 535                 540                 


Thr Pro Lys Ser Asp Ile Tyr Ser Phe Gly Val Val Leu Leu Glu Ile 
545                 550                 555                 560 


Ile Thr Gly Leu Pro Ala Val Asp Glu His Arg Glu Pro Gln Leu Leu 
                565                 570                 575     


Leu Asp Ile Lys Glu Glu Ile Glu Asp Glu Glu Lys Thr Ile Glu Asp 
            580                 585                 590         


Tyr Ile Asp Lys Lys Met Asn Asp Ala Asp Ser Thr Ser Val Glu Ala 
        595                 600                 605             


Met Tyr Ser Val Ala Ser Gln Cys Leu His Glu Lys Lys Asn Lys Arg 
    610                 615                 620                 


Pro Asp Ile Lys Lys Val Gln Gln Leu Leu Gln Glu Met Thr Ala Ser 
625                 630                 635                 640 


<210> 654
<211> 374
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 654
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Thr Ile Ile Gly Val Ser Val Leu Ser Val 
                165                 170                 175     


Leu Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe His 
            180                 185                 190         


Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn Ile 
        195                 200                 205             


Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val Arg 
    210                 215                 220                 


Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln Leu 
225                 230                 235                 240 


Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala Asn 
                245                 250                 255     


Ile Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val Val 
            260                 265                 270         


Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu Ile 
        275                 280                 285             


Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe Ile 
    290                 295                 300                 


Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu Leu 
305                 310                 315                 320 


Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser Val 
                325                 330                 335     


Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu Asp 
            340                 345                 350         


Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn Trp 
        355                 360                 365             


Gln Glu Ala Thr Ser Ile 
    370                 


<210> 655
<211> 352
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 655
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Thr Ile Ile Gly Val Ser Val Leu Ser Val Leu Val Val Ser Val Val 
145                 150                 155                 160 


Ala Val Leu Val Tyr Lys Phe Tyr Phe His Leu Met Leu Leu Ala Gly 
                165                 170                 175     


Cys Ile Lys Tyr Gly Arg Gly Glu Asn Ile Tyr Asp Ala Phe Val Ile 
            180                 185                 190         


Tyr Ser Ser Gln Asp Glu Asp Trp Val Arg Asn Glu Leu Val Lys Asn 
        195                 200                 205             


Leu Glu Glu Gly Val Pro Pro Phe Gln Leu Cys Leu His Tyr Arg Asp 
    210                 215                 220                 


Phe Ile Pro Gly Val Ala Ile Ala Ala Asn Ile Ile His Glu Gly Phe 
225                 230                 235                 240 


His Lys Ser Arg Lys Val Ile Val Val Val Ser Gln His Phe Ile Gln 
                245                 250                 255     


Ser Arg Trp Cys Ile Phe Glu Tyr Glu Ile Ala Gln Thr Trp Gln Phe 
            260                 265                 270         


Leu Ser Ser Arg Ala Gly Ile Ile Phe Ile Val Leu Gln Lys Val Glu 
        275                 280                 285             


Lys Thr Leu Leu Arg Gln Gln Val Glu Leu Tyr Arg Leu Leu Ser Arg 
    290                 295                 300                 


Asn Thr Tyr Leu Glu Trp Glu Asp Ser Val Leu Gly Arg His Ile Phe 
305                 310                 315                 320 


Trp Arg Arg Leu Arg Lys Ala Leu Leu Asp Gly Lys Ser Trp Asn Pro 
                325                 330                 335     


Glu Gly Thr Val Gly Thr Gly Cys Asn Trp Gln Glu Ala Thr Ser Ile 
            340                 345                 350         


<210> 656
<211> 384
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 656
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Met Phe Trp Val Gln Val Leu Leu Ala Gly 
                165                 170                 175     


Leu Val Val Pro Leu Leu Leu Gly Ala Thr Leu Thr Tyr Thr Tyr Arg 
            180                 185                 190         


His Cys Trp Pro His Lys Pro Leu Val Thr Ala Asp Glu Ala Gly Met 
        195                 200                 205             


Glu Ala Leu Thr Pro Pro Pro Ala Thr His Leu Ser Pro Leu Asp Ser 
    210                 215                 220                 


Ala His Thr Leu Leu Ala Pro Pro Asp Ser Ser Glu Lys Ile Cys Thr 
225                 230                 235                 240 


Val Gln Leu Val Gly Asn Ser Trp Thr Pro Gly Tyr Pro Glu Thr Gln 
                245                 250                 255     


Glu Ala Leu Cys Pro Gln Val Thr Trp Ser Trp Asp Gln Leu Pro Ser 
            260                 265                 270         


Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu Ser Pro Glu Ser Pro 
        275                 280                 285             


Ala Gly Ser Pro Ala Met Met Leu Gln Pro Gly Pro Gln Leu Tyr Asp 
    290                 295                 300                 


Val Met Asp Ala Val Pro Ala Arg Arg Trp Lys Glu Phe Val Arg Thr 
305                 310                 315                 320 


Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala Val Glu Val Glu Ile Gly 
                325                 330                 335     


Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys Arg Trp Arg Gln Gln 
            340                 345                 350         


Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala Ala Leu Glu Arg Met Gly 
        355                 360                 365             


Leu Asp Gly Cys Val Glu Asp Leu Arg Ser Arg Leu Gln Arg Gly Pro 
    370                 375                 380                 


<210> 657
<211> 362
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 657
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Met Phe Trp Val Gln Val Leu Leu Ala Gly Leu Val Val Pro Leu Leu 
145                 150                 155                 160 


Leu Gly Ala Thr Leu Thr Tyr Thr Tyr Arg His Cys Trp Pro His Lys 
                165                 170                 175     


Pro Leu Val Thr Ala Asp Glu Ala Gly Met Glu Ala Leu Thr Pro Pro 
            180                 185                 190         


Pro Ala Thr His Leu Ser Pro Leu Asp Ser Ala His Thr Leu Leu Ala 
        195                 200                 205             


Pro Pro Asp Ser Ser Glu Lys Ile Cys Thr Val Gln Leu Val Gly Asn 
    210                 215                 220                 


Ser Trp Thr Pro Gly Tyr Pro Glu Thr Gln Glu Ala Leu Cys Pro Gln 
225                 230                 235                 240 


Val Thr Trp Ser Trp Asp Gln Leu Pro Ser Arg Ala Leu Gly Pro Ala 
                245                 250                 255     


Ala Ala Pro Thr Leu Ser Pro Glu Ser Pro Ala Gly Ser Pro Ala Met 
            260                 265                 270         


Met Leu Gln Pro Gly Pro Gln Leu Tyr Asp Val Met Asp Ala Val Pro 
        275                 280                 285             


Ala Arg Arg Trp Lys Glu Phe Val Arg Thr Leu Gly Leu Arg Glu Ala 
    290                 295                 300                 


Glu Ile Glu Ala Val Glu Val Glu Ile Gly Arg Phe Arg Asp Gln Gln 
305                 310                 315                 320 


Tyr Glu Met Leu Lys Arg Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly 
                325                 330                 335     


Ala Val Tyr Ala Ala Leu Glu Arg Met Gly Leu Asp Gly Cys Val Glu 
            340                 345                 350         


Asp Leu Arg Ser Arg Leu Gln Arg Gly Pro 
        355                 360         


<210> 658
<211> 837
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 658
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Ala Ser Ser Gly Met 
        195                 200                 205             


Ala Asp Ser Ala Asn His Leu Pro Phe Phe Phe Gly Asn Ile Thr Arg 
    210                 215                 220                 


Glu Glu Ala Glu Asp Tyr Leu Val Gln Gly Gly Met Ser Asp Gly Leu 
225                 230                 235                 240 


Tyr Leu Leu Arg Gln Ser Arg Asn Tyr Leu Gly Gly Phe Ala Leu Ser 
                245                 250                 255     


Val Ala His Gly Arg Lys Ala His His Tyr Thr Ile Glu Arg Glu Leu 
            260                 265                 270         


Asn Gly Thr Tyr Ala Ile Ala Gly Gly Arg Thr His Ala Ser Pro Ala 
        275                 280                 285             


Asp Leu Cys His Tyr His Ser Gln Glu Ser Asp Gly Leu Val Cys Leu 
    290                 295                 300                 


Leu Lys Lys Pro Phe Asn Arg Pro Gln Gly Val Gln Pro Lys Thr Gly 
305                 310                 315                 320 


Pro Phe Glu Asp Leu Lys Glu Asn Leu Ile Arg Glu Tyr Val Lys Gln 
                325                 330                 335     


Thr Trp Asn Leu Gln Gly Gln Ala Leu Glu Gln Ala Ile Ile Ser Gln 
            340                 345                 350         


Lys Pro Gln Leu Glu Lys Leu Ile Ala Thr Thr Ala His Glu Lys Met 
        355                 360                 365             


Pro Trp Phe His Gly Lys Ile Ser Arg Glu Glu Ser Glu Gln Ile Val 
    370                 375                 380                 


Leu Ile Gly Ser Lys Thr Asn Gly Lys Phe Leu Ile Arg Ala Arg Asp 
385                 390                 395                 400 


Asn Asn Gly Ser Tyr Ala Leu Cys Leu Leu His Glu Gly Lys Val Leu 
                405                 410                 415     


His Tyr Arg Ile Asp Lys Asp Lys Thr Gly Lys Leu Ser Ile Pro Glu 
            420                 425                 430         


Gly Lys Lys Phe Asp Thr Leu Trp Gln Leu Val Glu His Tyr Ser Tyr 
        435                 440                 445             


Lys Ala Asp Gly Leu Leu Arg Val Leu Thr Val Pro Cys Gln Lys Ile 
    450                 455                 460                 


Gly Thr Gln Gly Asn Val Asn Phe Gly Gly Arg Pro Gln Leu Pro Gly 
465                 470                 475                 480 


Ser His Pro Ala Thr Trp Ser Ala Gly Gly Ile Ile Ser Arg Ile Lys 
                485                 490                 495     


Ser Tyr Ser Phe Pro Lys Pro Gly His Arg Lys Ser Ser Pro Ala Gln 
            500                 505                 510         


Gly Asn Arg Gln Glu Ser Thr Val Ser Phe Asn Pro Tyr Glu Pro Glu 
        515                 520                 525             


Leu Ala Pro Trp Ala Ala Asp Lys Gly Pro Gln Arg Glu Ala Leu Pro 
    530                 535                 540                 


Met Asp Thr Glu Val Tyr Glu Ser Pro Tyr Ala Asp Pro Glu Glu Ile 
545                 550                 555                 560 


Arg Pro Lys Glu Val Tyr Leu Asp Arg Lys Leu Leu Thr Leu Glu Asp 
                565                 570                 575     


Lys Glu Leu Gly Ser Gly Asn Phe Gly Thr Val Lys Lys Gly Tyr Tyr 
            580                 585                 590         


Gln Met Lys Lys Val Val Lys Thr Val Ala Val Lys Ile Leu Lys Asn 
        595                 600                 605             


Glu Ala Asn Asp Pro Ala Leu Lys Asp Glu Leu Leu Ala Glu Ala Asn 
    610                 615                 620                 


Val Met Gln Gln Leu Asp Asn Pro Tyr Ile Val Arg Met Ile Gly Ile 
625                 630                 635                 640 


Cys Glu Ala Glu Ser Trp Met Leu Val Met Glu Met Ala Glu Leu Gly 
                645                 650                 655     


Pro Leu Asn Lys Tyr Leu Gln Gln Asn Arg His Val Lys Asp Lys Asn 
            660                 665                 670         


Ile Ile Glu Leu Val His Gln Val Ser Met Gly Met Lys Tyr Leu Glu 
        675                 680                 685             


Glu Ser Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Leu 
    690                 695                 700                 


Val Thr Gln His Tyr Ala Lys Ile Ser Asp Phe Gly Leu Ser Lys Ala 
705                 710                 715                 720 


Leu Arg Ala Asp Glu Asn Tyr Tyr Lys Ala Gln Thr His Gly Lys Trp 
                725                 730                 735     


Pro Val Lys Trp Tyr Ala Pro Glu Cys Ile Asn Tyr Tyr Lys Phe Ser 
            740                 745                 750         


Ser Lys Ser Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Ala Phe 
        755                 760                 765             


Ser Tyr Gly Gln Lys Pro Tyr Arg Gly Met Lys Gly Ser Glu Val Thr 
    770                 775                 780                 


Ala Met Leu Glu Lys Gly Glu Arg Met Gly Cys Pro Ala Gly Cys Pro 
785                 790                 795                 800 


Arg Glu Met Tyr Asp Leu Met Asn Leu Cys Trp Thr Tyr Asp Val Glu 
                805                 810                 815     


Asn Arg Pro Gly Phe Ala Ala Val Glu Leu Arg Leu Arg Asn Tyr Tyr 
            820                 825                 830         


Tyr Asp Val Val Asn 
        835         


<210> 659
<211> 815
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 659
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                165                 170                 175     


Arg Leu Leu His Ser Ala Ser Ser Gly Met Ala Asp Ser Ala Asn His 
            180                 185                 190         


Leu Pro Phe Phe Phe Gly Asn Ile Thr Arg Glu Glu Ala Glu Asp Tyr 
        195                 200                 205             


Leu Val Gln Gly Gly Met Ser Asp Gly Leu Tyr Leu Leu Arg Gln Ser 
    210                 215                 220                 


Arg Asn Tyr Leu Gly Gly Phe Ala Leu Ser Val Ala His Gly Arg Lys 
225                 230                 235                 240 


Ala His His Tyr Thr Ile Glu Arg Glu Leu Asn Gly Thr Tyr Ala Ile 
                245                 250                 255     


Ala Gly Gly Arg Thr His Ala Ser Pro Ala Asp Leu Cys His Tyr His 
            260                 265                 270         


Ser Gln Glu Ser Asp Gly Leu Val Cys Leu Leu Lys Lys Pro Phe Asn 
        275                 280                 285             


Arg Pro Gln Gly Val Gln Pro Lys Thr Gly Pro Phe Glu Asp Leu Lys 
    290                 295                 300                 


Glu Asn Leu Ile Arg Glu Tyr Val Lys Gln Thr Trp Asn Leu Gln Gly 
305                 310                 315                 320 


Gln Ala Leu Glu Gln Ala Ile Ile Ser Gln Lys Pro Gln Leu Glu Lys 
                325                 330                 335     


Leu Ile Ala Thr Thr Ala His Glu Lys Met Pro Trp Phe His Gly Lys 
            340                 345                 350         


Ile Ser Arg Glu Glu Ser Glu Gln Ile Val Leu Ile Gly Ser Lys Thr 
        355                 360                 365             


Asn Gly Lys Phe Leu Ile Arg Ala Arg Asp Asn Asn Gly Ser Tyr Ala 
    370                 375                 380                 


Leu Cys Leu Leu His Glu Gly Lys Val Leu His Tyr Arg Ile Asp Lys 
385                 390                 395                 400 


Asp Lys Thr Gly Lys Leu Ser Ile Pro Glu Gly Lys Lys Phe Asp Thr 
                405                 410                 415     


Leu Trp Gln Leu Val Glu His Tyr Ser Tyr Lys Ala Asp Gly Leu Leu 
            420                 425                 430         


Arg Val Leu Thr Val Pro Cys Gln Lys Ile Gly Thr Gln Gly Asn Val 
        435                 440                 445             


Asn Phe Gly Gly Arg Pro Gln Leu Pro Gly Ser His Pro Ala Thr Trp 
    450                 455                 460                 


Ser Ala Gly Gly Ile Ile Ser Arg Ile Lys Ser Tyr Ser Phe Pro Lys 
465                 470                 475                 480 


Pro Gly His Arg Lys Ser Ser Pro Ala Gln Gly Asn Arg Gln Glu Ser 
                485                 490                 495     


Thr Val Ser Phe Asn Pro Tyr Glu Pro Glu Leu Ala Pro Trp Ala Ala 
            500                 505                 510         


Asp Lys Gly Pro Gln Arg Glu Ala Leu Pro Met Asp Thr Glu Val Tyr 
        515                 520                 525             


Glu Ser Pro Tyr Ala Asp Pro Glu Glu Ile Arg Pro Lys Glu Val Tyr 
    530                 535                 540                 


Leu Asp Arg Lys Leu Leu Thr Leu Glu Asp Lys Glu Leu Gly Ser Gly 
545                 550                 555                 560 


Asn Phe Gly Thr Val Lys Lys Gly Tyr Tyr Gln Met Lys Lys Val Val 
                565                 570                 575     


Lys Thr Val Ala Val Lys Ile Leu Lys Asn Glu Ala Asn Asp Pro Ala 
            580                 585                 590         


Leu Lys Asp Glu Leu Leu Ala Glu Ala Asn Val Met Gln Gln Leu Asp 
        595                 600                 605             


Asn Pro Tyr Ile Val Arg Met Ile Gly Ile Cys Glu Ala Glu Ser Trp 
    610                 615                 620                 


Met Leu Val Met Glu Met Ala Glu Leu Gly Pro Leu Asn Lys Tyr Leu 
625                 630                 635                 640 


Gln Gln Asn Arg His Val Lys Asp Lys Asn Ile Ile Glu Leu Val His 
                645                 650                 655     


Gln Val Ser Met Gly Met Lys Tyr Leu Glu Glu Ser Asn Phe Val His 
            660                 665                 670         


Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Val Thr Gln His Tyr Ala 
        675                 680                 685             


Lys Ile Ser Asp Phe Gly Leu Ser Lys Ala Leu Arg Ala Asp Glu Asn 
    690                 695                 700                 


Tyr Tyr Lys Ala Gln Thr His Gly Lys Trp Pro Val Lys Trp Tyr Ala 
705                 710                 715                 720 


Pro Glu Cys Ile Asn Tyr Tyr Lys Phe Ser Ser Lys Ser Asp Val Trp 
                725                 730                 735     


Ser Phe Gly Val Leu Met Trp Glu Ala Phe Ser Tyr Gly Gln Lys Pro 
            740                 745                 750         


Tyr Arg Gly Met Lys Gly Ser Glu Val Thr Ala Met Leu Glu Lys Gly 
        755                 760                 765             


Glu Arg Met Gly Cys Pro Ala Gly Cys Pro Arg Glu Met Tyr Asp Leu 
    770                 775                 780                 


Met Asn Leu Cys Trp Thr Tyr Asp Val Glu Asn Arg Pro Gly Phe Ala 
785                 790                 795                 800 


Ala Val Glu Leu Arg Leu Arg Asn Tyr Tyr Tyr Asp Val Val Asn 
                805                 810                 815 


<210> 660
<211> 714
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 660
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Gly Cys Ile Lys Ser 
        195                 200                 205             


Lys Gly Lys Asp Ser Leu Ser Asp Asp Gly Val Asp Leu Lys Thr Gln 
    210                 215                 220                 


Pro Val Arg Asn Thr Glu Arg Thr Ile Tyr Val Arg Asp Pro Thr Ser 
225                 230                 235                 240 


Asn Lys Gln Gln Arg Pro Val Pro Glu Ser Gln Leu Leu Pro Gly Gln 
                245                 250                 255     


Arg Phe Gln Thr Lys Asp Pro Glu Glu Gln Gly Asp Ile Val Val Ala 
            260                 265                 270         


Leu Tyr Pro Tyr Asp Gly Ile His Pro Asp Asp Leu Ser Phe Lys Lys 
        275                 280                 285             


Gly Glu Lys Met Lys Val Leu Glu Glu His Gly Glu Trp Trp Lys Ala 
    290                 295                 300                 


Lys Ser Leu Leu Thr Lys Lys Glu Gly Phe Ile Pro Ser Asn Tyr Val 
305                 310                 315                 320 


Ala Lys Leu Asn Thr Leu Glu Thr Glu Glu Trp Phe Phe Lys Asp Ile 
                325                 330                 335     


Thr Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro Gly Asn Ser Ala 
            340                 345                 350         


Gly Ala Phe Leu Ile Arg Glu Ser Glu Thr Leu Lys Gly Ser Phe Ser 
        355                 360                 365             


Leu Ser Val Arg Asp Phe Asp Pro Val His Gly Asp Val Ile Lys His 
    370                 375                 380                 


Tyr Lys Ile Arg Ser Leu Asp Asn Gly Gly Tyr Tyr Ile Ser Pro Arg 
385                 390                 395                 400 


Ile Thr Phe Pro Cys Ile Ser Asp Met Ile Lys His Tyr Gln Lys Gln 
                405                 410                 415     


Ala Asp Gly Leu Cys Arg Arg Leu Glu Lys Ala Cys Ile Ser Pro Lys 
            420                 425                 430         


Pro Gln Lys Pro Trp Asp Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser 
        435                 440                 445             


Ile Lys Leu Val Lys Arg Leu Gly Ala Gly Gln Phe Gly Glu Val Trp 
    450                 455                 460                 


Met Gly Tyr Tyr Asn Asn Ser Thr Lys Val Ala Val Lys Thr Leu Lys 
465                 470                 475                 480 


Pro Gly Thr Met Ser Val Gln Ala Phe Leu Glu Glu Ala Asn Leu Met 
                485                 490                 495     


Lys Thr Leu Gln His Asp Lys Leu Val Arg Leu Tyr Ala Val Val Thr 
            500                 505                 510         


Arg Glu Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Ala Lys Gly Ser 
        515                 520                 525             


Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly Gly Lys Val Leu Leu Pro 
    530                 535                 540                 


Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala Glu Gly Met Ala Tyr Ile 
545                 550                 555                 560 


Glu Arg Lys Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Val Leu 
                565                 570                 575     


Val Ser Glu Ser Leu Met Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg 
            580                 585                 590         


Val Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys Phe Pro 
        595                 600                 605             


Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Phe Gly Cys Phe Thr Ile 
    610                 615                 620                 


Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Tyr Glu Ile Val Thr 
625                 630                 635                 640 


Tyr Gly Lys Ile Pro Tyr Pro Gly Arg Thr Asn Ala Asp Val Met Thr 
                645                 650                 655     


Ala Leu Ser Gln Gly Tyr Arg Met Pro Arg Val Glu Asn Cys Pro Asp 
            660                 665                 670         


Glu Leu Tyr Asp Ile Met Lys Met Cys Trp Lys Glu Lys Ala Glu Glu 
        675                 680                 685             


Arg Pro Thr Phe Asp Tyr Leu Gln Ser Val Leu Asp Asp Phe Tyr Thr 
    690                 695                 700                 


Ala Thr Glu Gly Gln Tyr Gln Gln Gln Pro 
705                 710                 


<210> 661
<211> 692
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 661
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                165                 170                 175     


Arg Leu Leu His Ser Gly Cys Ile Lys Ser Lys Gly Lys Asp Ser Leu 
            180                 185                 190         


Ser Asp Asp Gly Val Asp Leu Lys Thr Gln Pro Val Arg Asn Thr Glu 
        195                 200                 205             


Arg Thr Ile Tyr Val Arg Asp Pro Thr Ser Asn Lys Gln Gln Arg Pro 
    210                 215                 220                 


Val Pro Glu Ser Gln Leu Leu Pro Gly Gln Arg Phe Gln Thr Lys Asp 
225                 230                 235                 240 


Pro Glu Glu Gln Gly Asp Ile Val Val Ala Leu Tyr Pro Tyr Asp Gly 
                245                 250                 255     


Ile His Pro Asp Asp Leu Ser Phe Lys Lys Gly Glu Lys Met Lys Val 
            260                 265                 270         


Leu Glu Glu His Gly Glu Trp Trp Lys Ala Lys Ser Leu Leu Thr Lys 
        275                 280                 285             


Lys Glu Gly Phe Ile Pro Ser Asn Tyr Val Ala Lys Leu Asn Thr Leu 
    290                 295                 300                 


Glu Thr Glu Glu Trp Phe Phe Lys Asp Ile Thr Arg Lys Asp Ala Glu 
305                 310                 315                 320 


Arg Gln Leu Leu Ala Pro Gly Asn Ser Ala Gly Ala Phe Leu Ile Arg 
                325                 330                 335     


Glu Ser Glu Thr Leu Lys Gly Ser Phe Ser Leu Ser Val Arg Asp Phe 
            340                 345                 350         


Asp Pro Val His Gly Asp Val Ile Lys His Tyr Lys Ile Arg Ser Leu 
        355                 360                 365             


Asp Asn Gly Gly Tyr Tyr Ile Ser Pro Arg Ile Thr Phe Pro Cys Ile 
    370                 375                 380                 


Ser Asp Met Ile Lys His Tyr Gln Lys Gln Ala Asp Gly Leu Cys Arg 
385                 390                 395                 400 


Arg Leu Glu Lys Ala Cys Ile Ser Pro Lys Pro Gln Lys Pro Trp Asp 
                405                 410                 415     


Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser Ile Lys Leu Val Lys Arg 
            420                 425                 430         


Leu Gly Ala Gly Gln Phe Gly Glu Val Trp Met Gly Tyr Tyr Asn Asn 
        435                 440                 445             


Ser Thr Lys Val Ala Val Lys Thr Leu Lys Pro Gly Thr Met Ser Val 
    450                 455                 460                 


Gln Ala Phe Leu Glu Glu Ala Asn Leu Met Lys Thr Leu Gln His Asp 
465                 470                 475                 480 


Lys Leu Val Arg Leu Tyr Ala Val Val Thr Arg Glu Glu Pro Ile Tyr 
                485                 490                 495     


Ile Ile Thr Glu Tyr Met Ala Lys Gly Ser Leu Leu Asp Phe Leu Lys 
            500                 505                 510         


Ser Asp Glu Gly Gly Lys Val Leu Leu Pro Lys Leu Ile Asp Phe Ser 
        515                 520                 525             


Ala Gln Ile Ala Glu Gly Met Ala Tyr Ile Glu Arg Lys Asn Tyr Ile 
    530                 535                 540                 


His Arg Asp Leu Arg Ala Ala Asn Val Leu Val Ser Glu Ser Leu Met 
545                 550                 555                 560 


Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Val Ile Glu Asp Asn Glu 
                565                 570                 575     


Tyr Thr Ala Arg Glu Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro 
            580                 585                 590         


Glu Ala Ile Asn Phe Gly Cys Phe Thr Ile Lys Ser Asp Val Trp Ser 
        595                 600                 605             


Phe Gly Ile Leu Leu Tyr Glu Ile Val Thr Tyr Gly Lys Ile Pro Tyr 
    610                 615                 620                 


Pro Gly Arg Thr Asn Ala Asp Val Met Thr Ala Leu Ser Gln Gly Tyr 
625                 630                 635                 640 


Arg Met Pro Arg Val Glu Asn Cys Pro Asp Glu Leu Tyr Asp Ile Met 
                645                 650                 655     


Lys Met Cys Trp Lys Glu Lys Ala Glu Glu Arg Pro Thr Phe Asp Tyr 
            660                 665                 670         


Leu Gln Ser Val Leu Asp Asp Phe Tyr Thr Ala Thr Glu Gly Gln Tyr 
        675                 680                 685             


Gln Gln Gln Pro 
    690         


<210> 662
<211> 745
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 662
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Gly Cys Ile Lys Ser 
        195                 200                 205             


Lys Glu Asn Lys Ser Pro Ala Ile Lys Tyr Arg Pro Glu Asn Thr Pro 
    210                 215                 220                 


Glu Pro Val Ser Thr Ser Val Ser His Tyr Gly Ala Glu Pro Thr Thr 
225                 230                 235                 240 


Val Ser Pro Cys Pro Ser Ser Ser Ala Lys Gly Thr Ala Val Asn Phe 
                245                 250                 255     


Ser Ser Leu Ser Met Thr Pro Phe Gly Gly Ser Ser Gly Val Thr Pro 
            260                 265                 270         


Phe Gly Gly Ala Ser Ser Ser Phe Ser Val Val Pro Ser Ser Tyr Pro 
        275                 280                 285             


Ala Gly Leu Thr Gly Gly Val Thr Ile Phe Val Ala Leu Tyr Asp Tyr 
    290                 295                 300                 


Glu Ala Arg Thr Thr Glu Asp Leu Ser Phe Lys Lys Gly Glu Arg Phe 
305                 310                 315                 320 


Gln Ile Ile Asn Asn Thr Glu Gly Asp Trp Trp Glu Ala Arg Ser Ile 
                325                 330                 335     


Ala Thr Gly Lys Asn Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Ala 
            340                 345                 350         


Asp Ser Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys Met Gly Arg Lys 
        355                 360                 365             


Asp Ala Glu Arg Leu Leu Leu Asn Pro Gly Asn Gln Arg Gly Ile Phe 
    370                 375                 380                 


Leu Val Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile 
385                 390                 395                 400 


Arg Asp Trp Asp Glu Ile Arg Gly Asp Asn Val Lys His Tyr Lys Ile 
                405                 410                 415     


Arg Lys Leu Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe 
            420                 425                 430         


Asp Thr Leu Gln Lys Leu Val Lys His Tyr Thr Glu His Ala Asp Gly 
        435                 440                 445             


Leu Cys His Lys Leu Thr Thr Val Cys Pro Thr Val Lys Pro Gln Thr 
    450                 455                 460                 


Gln Gly Leu Ala Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser Leu Arg 
465                 470                 475                 480 


Leu Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu Val Trp Met Gly 
                485                 490                 495     


Thr Trp Asn Gly Thr Thr Lys Val Ala Ile Lys Thr Leu Lys Pro Gly 
            500                 505                 510         


Thr Met Met Pro Glu Ala Phe Leu Gln Glu Ala Gln Ile Met Lys Lys 
        515                 520                 525             


Leu Arg His Asp Lys Leu Val Pro Leu Tyr Ala Val Val Ser Glu Glu 
    530                 535                 540                 


Pro Ile Tyr Ile Val Thr Glu Phe Met Ser Lys Gly Ser Leu Leu Asp 
545                 550                 555                 560 


Phe Leu Lys Glu Gly Asp Gly Lys Tyr Leu Lys Leu Pro Gln Leu Val 
                565                 570                 575     


Asp Met Ala Ala Gln Ile Ala Asp Gly Met Ala Tyr Ile Glu Arg Met 
            580                 585                 590         


Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Gly Glu 
        595                 600                 605             


Asn Leu Val Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu 
    610                 615                 620                 


Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp 
625                 630                 635                 640 


Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp 
                645                 650                 655     


Val Trp Ser Phe Gly Ile Leu Gln Thr Glu Leu Val Thr Lys Gly Arg 
            660                 665                 670         


Val Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu Glu Gln Val Glu 
        675                 680                 685             


Arg Gly Tyr Arg Met Pro Cys Pro Gln Gly Cys Pro Glu Ser Leu His 
    690                 695                 700                 


Glu Leu Met Asn Leu Cys Trp Lys Lys Asp Pro Asp Glu Arg Pro Thr 
705                 710                 715                 720 


Phe Glu Tyr Ile Gln Ser Phe Leu Glu Asp Tyr Phe Thr Ala Thr Glu 
                725                 730                 735     


Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
            740                 745 


<210> 663
<211> 723
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 663
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                165                 170                 175     


Arg Leu Leu His Ser Gly Cys Ile Lys Ser Lys Glu Asn Lys Ser Pro 
            180                 185                 190         


Ala Ile Lys Tyr Arg Pro Glu Asn Thr Pro Glu Pro Val Ser Thr Ser 
        195                 200                 205             


Val Ser His Tyr Gly Ala Glu Pro Thr Thr Val Ser Pro Cys Pro Ser 
    210                 215                 220                 


Ser Ser Ala Lys Gly Thr Ala Val Asn Phe Ser Ser Leu Ser Met Thr 
225                 230                 235                 240 


Pro Phe Gly Gly Ser Ser Gly Val Thr Pro Phe Gly Gly Ala Ser Ser 
                245                 250                 255     


Ser Phe Ser Val Val Pro Ser Ser Tyr Pro Ala Gly Leu Thr Gly Gly 
            260                 265                 270         


Val Thr Ile Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg Thr Thr Glu 
        275                 280                 285             


Asp Leu Ser Phe Lys Lys Gly Glu Arg Phe Gln Ile Ile Asn Asn Thr 
    290                 295                 300                 


Glu Gly Asp Trp Trp Glu Ala Arg Ser Ile Ala Thr Gly Lys Asn Gly 
305                 310                 315                 320 


Tyr Ile Pro Ser Asn Tyr Val Ala Pro Ala Asp Ser Ile Gln Ala Glu 
                325                 330                 335     


Glu Trp Tyr Phe Gly Lys Met Gly Arg Lys Asp Ala Glu Arg Leu Leu 
            340                 345                 350         


Leu Asn Pro Gly Asn Gln Arg Gly Ile Phe Leu Val Arg Glu Ser Glu 
        355                 360                 365             


Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp Asp Glu Ile 
    370                 375                 380                 


Arg Gly Asp Asn Val Lys His Tyr Lys Ile Arg Lys Leu Asp Asn Gly 
385                 390                 395                 400 


Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Asp Thr Leu Gln Lys Leu 
                405                 410                 415     


Val Lys His Tyr Thr Glu His Ala Asp Gly Leu Cys His Lys Leu Thr 
            420                 425                 430         


Thr Val Cys Pro Thr Val Lys Pro Gln Thr Gln Gly Leu Ala Lys Asp 
        435                 440                 445             


Ala Trp Glu Ile Pro Arg Glu Ser Leu Arg Leu Glu Val Lys Leu Gly 
    450                 455                 460                 


Gln Gly Cys Phe Gly Glu Val Trp Met Gly Thr Trp Asn Gly Thr Thr 
465                 470                 475                 480 


Lys Val Ala Ile Lys Thr Leu Lys Pro Gly Thr Met Met Pro Glu Ala 
                485                 490                 495     


Phe Leu Gln Glu Ala Gln Ile Met Lys Lys Leu Arg His Asp Lys Leu 
            500                 505                 510         


Val Pro Leu Tyr Ala Val Val Ser Glu Glu Pro Ile Tyr Ile Val Thr 
        515                 520                 525             


Glu Phe Met Ser Lys Gly Ser Leu Leu Asp Phe Leu Lys Glu Gly Asp 
    530                 535                 540                 


Gly Lys Tyr Leu Lys Leu Pro Gln Leu Val Asp Met Ala Ala Gln Ile 
545                 550                 555                 560 


Ala Asp Gly Met Ala Tyr Ile Glu Arg Met Asn Tyr Ile His Arg Asp 
                565                 570                 575     


Leu Arg Ala Ala Asn Ile Leu Val Gly Glu Asn Leu Val Cys Lys Ile 
            580                 585                 590         


Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala 
        595                 600                 605             


Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala 
    610                 615                 620                 


Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile 
625                 630                 635                 640 


Leu Gln Thr Glu Leu Val Thr Lys Gly Arg Val Pro Tyr Pro Gly Met 
                645                 650                 655     


Val Asn Arg Glu Val Leu Glu Gln Val Glu Arg Gly Tyr Arg Met Pro 
            660                 665                 670         


Cys Pro Gln Gly Cys Pro Glu Ser Leu His Glu Leu Met Asn Leu Cys 
        675                 680                 685             


Trp Lys Lys Asp Pro Asp Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser 
    690                 695                 700                 


Phe Leu Glu Asp Tyr Phe Thr Ala Thr Glu Pro Gln Tyr Gln Pro Gly 
705                 710                 715                 720 


Glu Asn Leu 
            


<210> 664
<211> 731
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 664
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Gly Cys Val Phe Cys 
        195                 200                 205             


Lys Lys Leu Glu Pro Val Ala Thr Ala Lys Glu Asp Ala Gly Leu Glu 
    210                 215                 220                 


Gly Asp Phe Arg Ser Tyr Gly Ala Ala Asp His Tyr Gly Pro Asp Pro 
225                 230                 235                 240 


Thr Lys Ala Arg Pro Ala Ser Ser Phe Ala His Ile Pro Asn Tyr Ser 
                245                 250                 255     


Asn Phe Ser Ser Gln Ala Ile Asn Pro Gly Phe Leu Asp Ser Gly Thr 
            260                 265                 270         


Ile Arg Gly Val Ser Gly Ile Gly Val Thr Leu Phe Ile Ala Leu Tyr 
        275                 280                 285             


Asp Tyr Glu Ala Arg Thr Glu Asp Asp Leu Thr Phe Thr Lys Gly Glu 
    290                 295                 300                 


Lys Phe His Ile Leu Asn Asn Thr Glu Gly Asp Trp Trp Glu Ala Arg 
305                 310                 315                 320 


Ser Leu Ser Ser Gly Lys Thr Gly Cys Ile Pro Ser Asn Tyr Val Ala 
                325                 330                 335     


Pro Val Asp Ser Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys Ile Gly 
            340                 345                 350         


Arg Lys Asp Ala Glu Arg Gln Leu Leu Ser Pro Gly Asn Pro Gln Gly 
        355                 360                 365             


Ala Phe Leu Ile Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu 
    370                 375                 380                 


Ser Ile Arg Asp Trp Asp Gln Thr Arg Gly Asp His Val Lys His Tyr 
385                 390                 395                 400 


Lys Ile Arg Lys Leu Asp Met Gly Gly Tyr Tyr Ile Thr Thr Arg Val 
                405                 410                 415     


Gln Phe Asn Ser Val Gln Glu Leu Val Gln His Tyr Met Glu Val Asn 
            420                 425                 430         


Asp Gly Leu Cys Asn Leu Leu Ile Ala Pro Cys Thr Ile Met Lys Pro 
        435                 440                 445             


Gln Thr Leu Gly Leu Ala Lys Asp Ala Trp Glu Ile Ser Arg Ser Ser 
    450                 455                 460                 


Ile Thr Leu Glu Arg Arg Leu Gly Thr Gly Cys Phe Gly Asp Val Trp 
465                 470                 475                 480 


Leu Gly Thr Trp Asn Gly Ser Thr Lys Val Ala Val Lys Thr Leu Lys 
                485                 490                 495     


Pro Gly Thr Met Ser Pro Lys Ala Phe Leu Glu Glu Ala Gln Val Met 
            500                 505                 510         


Lys Leu Leu Arg His Asp Lys Leu Val Gln Leu Tyr Ala Val Val Ser 
        515                 520                 525             


Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe Met Cys His Gly Ser Leu 
    530                 535                 540                 


Leu Asp Phe Leu Lys Asn Pro Glu Gly Gln Asp Leu Arg Leu Pro Gln 
545                 550                 555                 560 


Leu Val Asp Met Ala Ala Gln Val Ala Glu Gly Met Ala Tyr Met Glu 
                565                 570                 575     


Arg Met Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val 
            580                 585                 590         


Gly Glu Arg Leu Ala Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu 
        595                 600                 605             


Ile Lys Asp Asp Glu Tyr Asn Pro Cys Gln Gly Ser Lys Phe Pro Ile 
    610                 615                 620                 


Lys Trp Thr Ala Pro Glu Ala Ala Leu Phe Gly Arg Phe Thr Ile Lys 
625                 630                 635                 640 


Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Ile Thr Lys 
                645                 650                 655     


Gly Arg Ile Pro Tyr Pro Gly Met Asn Lys Arg Glu Val Leu Glu Gln 
            660                 665                 670         


Val Glu Gln Gly Tyr His Met Pro Cys Pro Pro Gly Cys Pro Ala Ser 
        675                 680                 685             


Leu Tyr Glu Ala Met Glu Gln Thr Trp Arg Leu Asp Pro Glu Glu Arg 
    690                 695                 700                 


Pro Thr Phe Glu Tyr Leu Gln Ser Phe Leu Glu Asp Tyr Phe Thr Ser 
705                 710                 715                 720 


Ala Glu Pro Gln Tyr Gln Pro Gly Asp Gln Thr 
                725                 730     


<210> 665
<211> 709
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 665
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                165                 170                 175     


Arg Leu Leu His Ser Gly Cys Val Phe Cys Lys Lys Leu Glu Pro Val 
            180                 185                 190         


Ala Thr Ala Lys Glu Asp Ala Gly Leu Glu Gly Asp Phe Arg Ser Tyr 
        195                 200                 205             


Gly Ala Ala Asp His Tyr Gly Pro Asp Pro Thr Lys Ala Arg Pro Ala 
    210                 215                 220                 


Ser Ser Phe Ala His Ile Pro Asn Tyr Ser Asn Phe Ser Ser Gln Ala 
225                 230                 235                 240 


Ile Asn Pro Gly Phe Leu Asp Ser Gly Thr Ile Arg Gly Val Ser Gly 
                245                 250                 255     


Ile Gly Val Thr Leu Phe Ile Ala Leu Tyr Asp Tyr Glu Ala Arg Thr 
            260                 265                 270         


Glu Asp Asp Leu Thr Phe Thr Lys Gly Glu Lys Phe His Ile Leu Asn 
        275                 280                 285             


Asn Thr Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Ser Ser Gly Lys 
    290                 295                 300                 


Thr Gly Cys Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
305                 310                 315                 320 


Ala Glu Glu Trp Tyr Phe Gly Lys Ile Gly Arg Lys Asp Ala Glu Arg 
                325                 330                 335     


Gln Leu Leu Ser Pro Gly Asn Pro Gln Gly Ala Phe Leu Ile Arg Glu 
            340                 345                 350         


Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp Asp 
        355                 360                 365             


Gln Thr Arg Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu Asp 
    370                 375                 380                 


Met Gly Gly Tyr Tyr Ile Thr Thr Arg Val Gln Phe Asn Ser Val Gln 
385                 390                 395                 400 


Glu Leu Val Gln His Tyr Met Glu Val Asn Asp Gly Leu Cys Asn Leu 
                405                 410                 415     


Leu Ile Ala Pro Cys Thr Ile Met Lys Pro Gln Thr Leu Gly Leu Ala 
            420                 425                 430         


Lys Asp Ala Trp Glu Ile Ser Arg Ser Ser Ile Thr Leu Glu Arg Arg 
        435                 440                 445             


Leu Gly Thr Gly Cys Phe Gly Asp Val Trp Leu Gly Thr Trp Asn Gly 
    450                 455                 460                 


Ser Thr Lys Val Ala Val Lys Thr Leu Lys Pro Gly Thr Met Ser Pro 
465                 470                 475                 480 


Lys Ala Phe Leu Glu Glu Ala Gln Val Met Lys Leu Leu Arg His Asp 
                485                 490                 495     


Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu Pro Ile Tyr Ile 
            500                 505                 510         


Val Thr Glu Phe Met Cys His Gly Ser Leu Leu Asp Phe Leu Lys Asn 
        515                 520                 525             


Pro Glu Gly Gln Asp Leu Arg Leu Pro Gln Leu Val Asp Met Ala Ala 
    530                 535                 540                 


Gln Val Ala Glu Gly Met Ala Tyr Met Glu Arg Met Asn Tyr Ile His 
545                 550                 555                 560 


Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Gly Glu Arg Leu Ala Cys 
                565                 570                 575     


Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Lys Asp Asp Glu Tyr 
            580                 585                 590         


Asn Pro Cys Gln Gly Ser Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu 
        595                 600                 605             


Ala Ala Leu Phe Gly Arg Phe Thr Ile Lys Ser Asp Val Trp Ser Phe 
    610                 615                 620                 


Gly Ile Leu Leu Thr Glu Leu Ile Thr Lys Gly Arg Ile Pro Tyr Pro 
625                 630                 635                 640 


Gly Met Asn Lys Arg Glu Val Leu Glu Gln Val Glu Gln Gly Tyr His 
                645                 650                 655     


Met Pro Cys Pro Pro Gly Cys Pro Ala Ser Leu Tyr Glu Ala Met Glu 
            660                 665                 670         


Gln Thr Trp Arg Leu Asp Pro Glu Glu Arg Pro Thr Phe Glu Tyr Leu 
        675                 680                 685             


Gln Ser Phe Leu Glu Asp Tyr Phe Thr Ser Ala Glu Pro Gln Tyr Gln 
    690                 695                 700                 


Pro Gly Asp Gln Thr 
705                 


<210> 666
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 666
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        195                 200                 205             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    210                 215                 220                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
225                 230                 235     


<210> 667
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 667
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Lys Arg Gly Arg 
                165                 170                 175     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            180                 185                 190         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        195                 200                 205             


Glu Gly Gly Cys Glu Leu 
    210                 


<210> 668
<211> 217
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 668
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys 
        195                 200                 205             


Val Tyr Ile Asn Met Pro Gly Arg Gly 
    210                 215         


<210> 669
<211> 195
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 669
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Leu Cys Ala Arg Pro 
                165                 170                 175     


Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro 
            180                 185                 190         


Gly Arg Gly 
        195 


<210> 670
<211> 234
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 670
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
        195                 200                 205             


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
    210                 215                 220                 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
225                 230                 


<210> 671
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 671
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                165                 170                 175     


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
            180                 185                 190         


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
        195                 200                 205             


Ala Tyr Arg Ser 
    210         


<210> 672
<211> 305
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 672
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
        195                 200                 205             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    210                 215                 220                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
225                 230                 235                 240 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                245                 250                 255     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            260                 265                 270         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        275                 280                 285             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    290                 295                 300                 


Arg 
305 


<210> 673
<211> 283
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 673
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
145                 150                 155                 160 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Val Lys Phe Ser 
                165                 170                 175     


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
            180                 185                 190         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        195                 200                 205             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    210                 215                 220                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
225                 230                 235                 240 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                245                 250                 255     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            260                 265                 270         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        275                 280             


<210> 674
<211> 199
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 674
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser 
        195                 


<210> 675
<211> 177
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 675
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val 
145                 150                 155                 160 


Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser 
                165                 170                 175     


Ser 


<210> 676
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 676
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210> 677
<211> 231
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 677
Met Ser Lys Gln Arg Gly Thr Phe Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Ser 
            20                  25                  30          


Gly Thr Glu Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Pro 
        35                  40                  45              


Ser Leu Asn His Gln Gly Ile Asp Lys Ile Tyr Asp Cys Gln Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Phe 
                85                  90                  95      


Leu Glu Gln Asn Asn Ser Ser Pro Asn Thr Arg Thr Gln Lys Ala Arg 
            100                 105                 110         


His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn Ser Cys 
        115                 120                 125             


Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu Leu Ala 
    130                 135                 140                 


Cys Thr Ser Lys Asn Ser Ser Leu Leu Ser Ile Asp Asn Glu Glu Glu 
145                 150                 155                 160 


Met Lys Phe Leu Ser Ile Ile Ser Pro Ser Ser Trp Ile Gly Val Phe 
                165                 170                 175     


Arg Asn Ser Ser His His Pro Trp Val Thr Met Asn Gly Leu Ala Phe 
            180                 185                 190         


Lys His Glu Ile Lys Asp Ser Asp Asn Ala Glu Leu Asn Cys Ala Val 
        195                 200                 205             


Leu Gln Val Asn Arg Leu Lys Ser Ala Gln Cys Gly Ser Ser Ile Ile 
    210                 215                 220                 


Tyr His Cys Lys His Lys Leu 
225                 230     


<210> 678
<211> 391
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 678
Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Met Phe Trp 
                165                 170                 175     


Val Gln Val Leu Leu Ala Gly Leu Val Val Pro Leu Leu Leu Gly Ala 
            180                 185                 190         


Thr Leu Thr Tyr Thr Tyr Arg His Cys Trp Pro His Lys Pro Leu Val 
        195                 200                 205             


Thr Ala Asp Glu Ala Gly Met Glu Ala Leu Thr Pro Pro Pro Ala Thr 
    210                 215                 220                 


His Leu Ser Pro Leu Asp Ser Ala His Thr Leu Leu Ala Pro Pro Asp 
225                 230                 235                 240 


Ser Ser Glu Lys Ile Cys Thr Val Gln Leu Val Gly Asn Ser Trp Thr 
                245                 250                 255     


Pro Gly Tyr Pro Glu Thr Gln Glu Ala Leu Cys Pro Gln Val Thr Trp 
            260                 265                 270         


Ser Trp Asp Gln Leu Pro Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro 
        275                 280                 285             


Thr Leu Ser Pro Glu Ser Pro Ala Gly Ser Pro Ala Met Met Leu Gln 
    290                 295                 300                 


Pro Gly Pro Gln Leu Tyr Asp Val Met Asp Ala Val Pro Ala Arg Arg 
305                 310                 315                 320 


Trp Lys Glu Phe Val Arg Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu 
                325                 330                 335     


Ala Val Glu Val Glu Ile Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met 
            340                 345                 350         


Leu Lys Arg Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr 
        355                 360                 365             


Ala Ala Leu Glu Arg Met Gly Leu Asp Gly Cys Val Glu Asp Leu Arg 
    370                 375                 380                 


Ser Arg Leu Gln Arg Gly Pro 
385                 390     


<210> 679
<211> 366
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 679
Gln Val Thr Asp Ile Asn Ser Lys Gly Leu Glu Leu Arg Lys Thr Val 
1               5                   10                  15      


Thr Thr Val Glu Thr Gln Asn Leu Glu Gly Leu His His Asp Gly Gln 
            20                  25                  30          


Phe Cys His Lys Pro Cys Pro Pro Gly Glu Arg Lys Ala Arg Asp Cys 
        35                  40                  45              


Thr Val Asn Gly Asp Glu Pro Asp Cys Val Pro Cys Gln Glu Gly Lys 
    50                  55                  60                  


Glu Tyr Thr Asp Lys Ala His Phe Ser Ser Lys Cys Arg Arg Cys Arg 
65                  70                  75                  80  


Leu Cys Asp Glu Gly His Gly Leu Glu Val Glu Ile Asn Cys Thr Arg 
                85                  90                  95      


Thr Gln Asn Thr Lys Cys Arg Cys Lys Pro Asn Phe Phe Cys Asn Ser 
            100                 105                 110         


Thr Val Cys Glu His Cys Asp Pro Cys Thr Lys Cys Glu His Gly Ile 
        115                 120                 125             


Ile Lys Glu Cys Thr Leu Thr Ser Asn Thr Lys Cys Lys Glu Glu Gly 
    130                 135                 140                 


Ser Arg Ser Asn Met Phe Trp Val Gln Val Leu Leu Ala Gly Leu Val 
145                 150                 155                 160 


Val Pro Leu Leu Leu Gly Ala Thr Leu Thr Tyr Thr Tyr Arg His Cys 
                165                 170                 175     


Trp Pro His Lys Pro Leu Val Thr Ala Asp Glu Ala Gly Met Glu Ala 
            180                 185                 190         


Leu Thr Pro Pro Pro Ala Thr His Leu Ser Pro Leu Asp Ser Ala His 
        195                 200                 205             


Thr Leu Leu Ala Pro Pro Asp Ser Ser Glu Lys Ile Cys Thr Val Gln 
    210                 215                 220                 


Leu Val Gly Asn Ser Trp Thr Pro Gly Tyr Pro Glu Thr Gln Glu Ala 
225                 230                 235                 240 


Leu Cys Pro Gln Val Thr Trp Ser Trp Asp Gln Leu Pro Ser Arg Ala 
                245                 250                 255     


Leu Gly Pro Ala Ala Ala Pro Thr Leu Ser Pro Glu Ser Pro Ala Gly 
            260                 265                 270         


Ser Pro Ala Met Met Leu Gln Pro Gly Pro Gln Leu Tyr Asp Val Met 
        275                 280                 285             


Asp Ala Val Pro Ala Arg Arg Trp Lys Glu Phe Val Arg Thr Leu Gly 
    290                 295                 300                 


Leu Arg Glu Ala Glu Ile Glu Ala Val Glu Val Glu Ile Gly Arg Phe 
305                 310                 315                 320 


Arg Asp Gln Gln Tyr Glu Met Leu Lys Arg Trp Arg Gln Gln Gln Pro 
                325                 330                 335     


Ala Gly Leu Gly Ala Val Tyr Ala Ala Leu Glu Arg Met Gly Leu Asp 
            340                 345                 350         


Gly Cys Val Glu Asp Leu Arg Ser Arg Leu Gln Arg Gly Pro 
        355                 360                 365     


<210> 680
<211> 472
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 680
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Ser Leu Lys Thr His 
            180                 185                 190         


Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser Pro Glu 
        195                 200                 205             


Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe Lys Lys 
    210                 215                 220                 


Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly Pro Trp 
225                 230                 235                 240 


Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His Pro Pro 
                245                 250                 255     


Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu Pro Ala 
            260                 265                 270         


Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp Pro Thr 
        275                 280                 285             


Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro 
    290                 295                 300                 


Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala Glu Gly 
305                 310                 315                 320 


Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala Leu 
                325                 330                 335     


Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp Pro Leu 
            340                 345                 350         


Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser Ala Gly 
        355                 360                 365             


Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg Leu Lys 
    370                 375                 380                 


Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro Trp Gly 
385                 390                 395                 400 


Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser Pro Leu 
                405                 410                 415     


Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly Ser Asp 
            420                 425                 430         


Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp Glu Gly 
        435                 440                 445             


Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro Pro Leu 
    450                 455                 460                 


Ser Ser Pro Gly Pro Gln Ala Ser 
465                 470         


<210> 681
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 681
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val 
145                 150                 155                 160 


Ile Ile Ile Phe Tyr Ser Leu Lys Thr His Pro Leu Trp Arg Leu Trp 
                165                 170                 175     


Lys Lys Ile Trp Ala Val Pro Ser Pro Glu Arg Phe Phe Met Pro Leu 
            180                 185                 190         


Tyr Lys Gly Cys Ser Gly Asp Phe Lys Lys Trp Val Gly Ala Pro Phe 
        195                 200                 205             


Thr Gly Ser Ser Leu Glu Leu Gly Pro Trp Ser Pro Glu Val Pro Ser 
    210                 215                 220                 


Thr Leu Glu Val Tyr Ser Cys His Pro Pro Arg Ser Pro Ala Lys Arg 
225                 230                 235                 240 


Leu Gln Leu Thr Glu Leu Gln Glu Pro Ala Glu Leu Val Glu Ser Asp 
                245                 250                 255     


Gly Val Pro Lys Pro Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly Gly 
            260                 265                 270         


Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser Ile 
        275                 280                 285             


Asp Thr Val Thr Val Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro Cys 
    290                 295                 300                 


Ser Cys Glu Asp Asp Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly Leu 
305                 310                 315                 320 


Glu Pro Ser Pro Gly Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr Thr 
                325                 330                 335     


Val Leu Ser Cys Gly Cys Val Ser Ala Gly Ser Pro Gly Leu Gly Gly 
            340                 345                 350         


Pro Leu Gly Ser Leu Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp Gly 
        355                 360                 365             


Glu Asp Trp Ala Gly Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly Gly 
    370                 375                 380                 


Val Ser Glu Ser Glu Ala Gly Ser Pro Leu Ala Gly Leu Asp Met Asp 
385                 390                 395                 400 


Thr Phe Asp Ser Gly Phe Val Gly Ser Asp Cys Ser Ser Pro Val Glu 
                405                 410                 415     


Cys Asp Phe Thr Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu 
            420                 425                 430         


Arg Gln Trp Val Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln 
        435                 440                 445             


Ala Ser 
    450 


<210> 682
<211> 272
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 682
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Thr Ile Pro Pro His Val Gln Lys Ser Val Asn 
            20                  25                  30          


Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln 
        35                  40                  45              


Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys 
    50                  55                  60                  


Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln 
65                  70                  75                  80  


Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu 
                85                  90                  95      


Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu 
            100                 105                 110         


Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro 
        115                 120                 125             


Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp 
    130                 135                 140                 


Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu 
145                 150                 155                 160 


Leu Val Ile Phe Gln Val Val Ile Ser Val Gly Ser Met Gly Leu Ile 
                165                 170                 175     


Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg 
            180                 185                 190         


Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly 
        195                 200                 205             


Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu 
    210                 215                 220                 


Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro 
225                 230                 235                 240 


Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln 
                245                 250                 255     


His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
            260                 265                 270         


<210> 683
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 683
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140                 


Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
145                 150                 155                 160 


Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys 
                165                 170                 175     


Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp 
            180                 185                 190         


Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser 
        195                 200                 205             


Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu 
    210                 215                 220                 


Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp 
225                 230                 235                 240 


Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
                245                 250     


<210> 684
<211> 221
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 684
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp 
            20                  25                  30          


Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu 
        35                  40                  45              


Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp 
    50                  55                  60                  


Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr 
65                  70                  75                  80  


Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys 
                85                  90                  95      


Ile Glu Leu Pro Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val 
            100                 105                 110         


Glu Leu Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu 
        115                 120                 125             


Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr 
    130                 135                 140                 


Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser 
145                 150                 155                 160 


Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp 
                165                 170                 175     


Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly 
            180                 185                 190         


Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro 
        195                 200                 205             


Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
    210                 215                 220     


<210> 685
<211> 200
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 685
Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Val 
1               5                   10                  15      


Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val 
            20                  25                  30          


Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp 
        35                  40                  45              


Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr Thr 
    50                  55                  60                  


Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro Thr 
65                  70                  75                  80  


Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Val Val Ile 
                85                  90                  95      


Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys Val Tyr Phe 
            100                 105                 110         


Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu 
        115                 120                 125             


Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val 
    130                 135                 140                 


Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu 
145                 150                 155                 160 


Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly 
                165                 170                 175     


Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro 
            180                 185                 190         


Cys Tyr Thr Leu Lys Pro Glu Thr 
        195                 200 


<210> 686
<211> 432
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 686
Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Ser Leu Lys Thr His Pro Leu Trp Arg Leu Trp Lys Lys 
145                 150                 155                 160 


Ile Trp Ala Val Pro Ser Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys 
                165                 170                 175     


Gly Cys Ser Gly Asp Phe Lys Lys Trp Val Gly Ala Pro Phe Thr Gly 
            180                 185                 190         


Ser Ser Leu Glu Leu Gly Pro Trp Ser Pro Glu Val Pro Ser Thr Leu 
        195                 200                 205             


Glu Val Tyr Ser Cys His Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln 
    210                 215                 220                 


Leu Thr Glu Leu Gln Glu Pro Ala Glu Leu Val Glu Ser Asp Gly Val 
225                 230                 235                 240 


Pro Lys Pro Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala 
                245                 250                 255     


Tyr Ser Glu Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr 
            260                 265                 270         


Val Thr Val Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys 
        275                 280                 285             


Glu Asp Asp Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro 
    290                 295                 300                 


Ser Pro Gly Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr Thr Val Leu 
305                 310                 315                 320 


Ser Cys Gly Cys Val Ser Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu 
                325                 330                 335     


Gly Ser Leu Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp 
            340                 345                 350         


Trp Ala Gly Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly Gly Val Ser 
        355                 360                 365             


Glu Ser Glu Ala Gly Ser Pro Leu Ala Gly Leu Asp Met Asp Thr Phe 
    370                 375                 380                 


Asp Ser Gly Phe Val Gly Ser Asp Cys Ser Ser Pro Val Glu Cys Asp 
385                 390                 395                 400 


Phe Thr Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln 
                405                 410                 415     


Trp Val Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
            420                 425                 430         


<210> 687
<211> 399
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 687
Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Val 
1               5                   10                  15      


Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val 
            20                  25                  30          


Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp 
        35                  40                  45              


Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr Thr 
    50                  55                  60                  


Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro Thr 
65                  70                  75                  80  


Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala Val 
                85                  90                  95      


Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met Val 
            100                 105                 110         


Tyr Ile Ser Leu Lys Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile 
        115                 120                 125             


Trp Ala Val Pro Ser Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly 
    130                 135                 140                 


Cys Ser Gly Asp Phe Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser 
145                 150                 155                 160 


Ser Leu Glu Leu Gly Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu 
                165                 170                 175     


Val Tyr Ser Cys His Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu 
            180                 185                 190         


Thr Glu Leu Gln Glu Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro 
        195                 200                 205             


Lys Pro Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr 
    210                 215                 220                 


Ser Glu Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val 
225                 230                 235                 240 


Thr Val Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu 
                245                 250                 255     


Asp Asp Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser 
            260                 265                 270         


Pro Gly Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser 
        275                 280                 285             


Cys Gly Cys Val Ser Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly 
    290                 295                 300                 


Ser Leu Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp 
305                 310                 315                 320 


Ala Gly Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu 
                325                 330                 335     


Ser Glu Ala Gly Ser Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp 
            340                 345                 350         


Ser Gly Phe Val Gly Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe 
        355                 360                 365             


Thr Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp 
    370                 375                 380                 


Val Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
385                 390                 395                     


