                         SEQUENCE LISTING

<110>  BIO-TECHNE CORPORATION
       Goetz, Christine  A.
       Bonnevier, Jody
       Hammerbeck, Christopher D.
       Resnik, Ernesto R.
       Munshi, Cyrus B.
       Tan, Enqing
 
<120>  ANTI-SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS ANTIBODIES

<130>  0541.000015WO01

<150>  US 63/117,960
<151>  2020-11-24

<150>  US 63/194,501
<151>  2021-05-28

<160>  104   

<170>  PatentIn version 3.5

<210>  1
<211>  107
<212>  PRT
<213>  mouse

<400>  1

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Phe 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  2
<211>  108
<212>  PRT
<213>  mouse

<400>  2

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Tyr Met 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  3
<211>  107
<212>  PRT
<213>  mouse

<400>  3

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  4
<211>  111
<212>  PRT
<213>  mouse

<400>  4

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Thr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Ser Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  5
<211>  111
<212>  PRT
<213>  mouse

<400>  5

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Ala Ser Phe Met His Trp Cys Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Tyr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  6
<211>  107
<212>  PRT
<213>  mouse

<400>  6

Asp Ile Val Leu Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  7
<211>  112
<212>  PRT
<213>  mouse

<400>  7

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Ala Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Phe Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  8
<211>  107
<212>  PRT
<213>  mouse

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  9
<211>  107
<212>  PRT
<213>  mouse

<400>  9

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Tyr Ser Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  10
<211>  107
<212>  PRT
<213>  mouse

<400>  10

Asp Val Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Val Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Ser Ser Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  11
<211>  107
<212>  PRT
<213>  mouse

<400>  11

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Met Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  12
<211>  107
<212>  PRT
<213>  mouse

<400>  12

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Val Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asp Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  13
<211>  107
<212>  PRT
<213>  mouse

<400>  13

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  14
<211>  107
<212>  PRT
<213>  mouse

<400>  14

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Asn Leu Glu Met Lys 
            100                 105         


<210>  15
<211>  107
<212>  PRT
<213>  mouse

<400>  15

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Val Pro Ala Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
65                  70                  75                  80  


Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Tyr Met Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  16
<211>  107
<212>  PRT
<213>  mouse

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Cys Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Ala Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Phe Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  17
<211>  118
<212>  PRT
<213>  mouse

<400>  17

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asn Pro Leu Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  18
<211>  120
<212>  PRT
<213>  mouse

<400>  18

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Phe Val Arg Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Ser Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Tyr Phe Gly Ser Gly Ser Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  19
<211>  118
<212>  PRT
<213>  mouse

<400>  19

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asn Pro Leu Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  20
<211>  121
<212>  PRT
<213>  mouse

<400>  20

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Thr Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Lys Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Glu Asp Asn Leu Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  21
<211>  121
<212>  PRT
<213>  mouse

<400>  21

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Ile Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Thr Gly Ser Thr Tyr Asn Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Lys Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Glu Asp Asn Leu Tyr Phe Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  22
<211>  119
<212>  PRT
<213>  mouse

<400>  22

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Ile Leu Phe Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  23
<211>  117
<212>  PRT
<213>  mouse

<400>  23

Gln Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ile Tyr 
            20                  25                  30          


Trp Met His Trp Val Gln Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asp Tyr Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  24
<211>  120
<212>  PRT
<213>  mouse

<400>  24

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Ile Val Asp Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  25
<211>  118
<212>  PRT
<213>  mouse

<400>  25

Glu Val Leu Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Gly Asn Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  26
<211>  118
<212>  PRT
<213>  mouse

<400>  26

Glu Val Leu Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Phe Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Gly Asn Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  27
<211>  119
<212>  PRT
<213>  mouse

<400>  27

Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Pro Gly Asn Gly Asp Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Lys Glu Asp Asp Gly Phe Tyr Pro Trp Phe Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  28
<211>  120
<212>  PRT
<213>  mouse

<400>  28

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Ser Ile His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Val Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Tyr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ser Asp Tyr Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  29
<211>  117
<212>  PRT
<213>  mouse

<400>  29

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Leu Gly Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Tyr Tyr Tyr Ala Met Asp Ser Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  30
<211>  118
<212>  PRT
<213>  mouse

<400>  30

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Ser Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Ser Ala Thr Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  31
<211>  120
<212>  PRT
<213>  mouse

<400>  31

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Asp Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  32
<211>  11
<212>  PRT
<213>  mouse

<400>  32

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Asn 
1               5                   10      


<210>  33
<211>  7
<212>  PRT
<213>  mouse

<400>  33

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  34
<211>  9
<212>  PRT
<213>  mouse

<400>  34

Leu Gln Tyr Asp Glu Phe Pro Tyr Thr 
1               5                   


<210>  35
<211>  10
<212>  PRT
<213>  mouse

<400>  35

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  36
<211>  7
<212>  PRT
<213>  mouse

<400>  36

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  37
<211>  11
<212>  PRT
<213>  mouse

<400>  37

Gln Gln Tyr His Ser Tyr Pro Tyr Met Tyr Thr 
1               5                   10      


<210>  38
<211>  15
<212>  PRT
<213>  mouse

<400>  38

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Ala Ser Phe Met His 
1               5                   10                  15  


<210>  39
<211>  7
<212>  PRT
<213>  mouse

<400>  39

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  mouse

<400>  40

Gln Gln Asn Tyr Glu Asp Pro Trp Thr 
1               5                   


<210>  41
<211>  11
<212>  PRT
<213>  mouse

<400>  41

Lys Ala Ser Gln Asn Val Arg Thr Ala Val Ala 
1               5                   10      


<210>  42
<211>  7
<212>  PRT
<213>  mouse

<400>  42

Leu Ala Ser Asn Arg His Thr 
1               5           


<210>  43
<211>  9
<212>  PRT
<213>  mouse

<400>  43

Leu Gln His Trp Asn Tyr Pro Leu Thr 
1               5                   


<210>  44
<211>  16
<212>  PRT
<213>  mouse

<400>  44

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  45
<211>  7
<212>  PRT
<213>  mouse

<400>  45

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  46
<211>  9
<212>  PRT
<213>  mouse

<400>  46

Met Gln His Leu Glu Tyr Pro Tyr Thr 
1               5                   


<210>  47
<211>  15
<212>  PRT
<213>  mouse

<400>  47

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Thr Ser Phe Met His 
1               5                   10                  15  


<210>  48
<211>  9
<212>  PRT
<213>  mouse

<400>  48

Gln Gln Asn Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  49
<211>  11
<212>  PRT
<213>  mouse

<400>  49

Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Ser 
1               5                   10      


<210>  50
<211>  7
<212>  PRT
<213>  mouse

<400>  50

Ala Ala Ser Thr Leu Asp Ser 
1               5           


<210>  51
<211>  9
<212>  PRT
<213>  mouse

<400>  51

Leu Gln Tyr Ala Ser Tyr Pro Trp Thr 
1               5                   


<210>  52
<211>  11
<212>  PRT
<213>  mouse

<400>  52

Arg Ala Ser Gln Ser Ile Gly Thr Ser Ile His 
1               5                   10      


<210>  53
<211>  7
<212>  PRT
<213>  mouse

<400>  53

Tyr Ala Ser Glu Ser Ile Ser 
1               5           


<210>  54
<211>  9
<212>  PRT
<213>  mouse

<400>  54

Gln Gln Ser Tyr Ser Trp Pro Thr Thr 
1               5                   


<210>  55
<211>  11
<212>  PRT
<213>  mouse

<400>  55

Arg Ala Ser Gln Ser Ile Gly Thr Ser Leu His 
1               5                   10      


<210>  56
<211>  7
<212>  PRT
<213>  mouse

<400>  56

Tyr Val Ser Glu Ser Ile Ser 
1               5           


<210>  57
<211>  9
<212>  PRT
<213>  mouse

<400>  57

Gln Gln Ser Ser Ser Trp Pro Thr Thr 
1               5                   


<210>  58
<211>  11
<212>  PRT
<213>  mouse

<400>  58

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  59
<211>  7
<212>  PRT
<213>  mouse

<400>  59

Arg Ala Asn Arg Met Val Asp 
1               5           


<210>  60
<211>  11
<212>  PRT
<213>  mouse

<400>  60

Arg Val Ser Lys Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  61
<211>  7
<212>  PRT
<213>  mouse

<400>  61

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  62
<211>  11
<212>  PRT
<213>  mouse

<400>  62

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  63
<211>  7
<212>  PRT
<213>  mouse

<400>  63

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  64
<211>  9
<212>  PRT
<213>  mouse

<400>  64

Gln Gln Tyr Asn Arg Tyr Pro Trp Thr 
1               5                   


<210>  65
<211>  11
<212>  PRT
<213>  mouse

<400>  65

Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  66
<211>  7
<212>  PRT
<213>  mouse

<400>  66

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  67
<211>  9
<212>  PRT
<213>  mouse

<400>  67

Gln Gln Tyr Ser Lys Leu Pro Phe Thr 
1               5                   


<210>  68
<211>  11
<212>  PRT
<213>  mouse

<400>  68

Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Cys 
1               5                   10      


<210>  69
<211>  5
<212>  PRT
<213>  mouse

<400>  69

Asn Tyr Thr Met His 
1               5   


<210>  70
<211>  17
<212>  PRT
<213>  mouse

<400>  70

Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  71
<211>  9
<212>  PRT
<213>  mouse

<400>  71

Arg Asn Pro Leu Tyr Ala Met Asp Tyr 
1               5                   


<210>  72
<211>  5
<212>  PRT
<213>  mouse

<400>  72

Asp Asp Tyr Met His 
1               5   


<210>  73
<211>  17
<212>  PRT
<213>  mouse

<400>  73

Trp Ile Asp Pro Glu Asn Gly Asn Ser Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  74
<211>  11
<212>  PRT
<213>  mouse

<400>  74

Gly Glu Tyr Phe Gly Ser Gly Ser Phe Ala Tyr 
1               5                   10      


<210>  75
<211>  5
<212>  PRT
<213>  mouse

<400>  75

Thr Tyr Thr Met His 
1               5   


<210>  76
<211>  5
<212>  PRT
<213>  mouse

<400>  76

Ser Tyr Trp Ile His 
1               5   


<210>  77
<211>  17
<212>  PRT
<213>  mouse

<400>  77

Arg Ile Tyr Pro Gly Thr Gly Ser Thr Tyr Asn Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  78
<211>  12
<212>  PRT
<213>  mouse

<400>  78

Gly Glu Asp Asn Leu Tyr Phe Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  79
<211>  5
<212>  PRT
<213>  mouse

<400>  79

Asp Ala Trp Met Asp 
1               5   


<210>  80
<211>  19
<212>  PRT
<213>  mouse

<400>  80

Glu Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  81
<211>  8
<212>  PRT
<213>  mouse

<400>  81

Phe Ile Thr Tyr Ala Met Asp Tyr 
1               5               


<210>  82
<211>  5
<212>  PRT
<213>  mouse

<400>  82

Ile Tyr Trp Met His 
1               5   


<210>  83
<211>  17
<212>  PRT
<213>  mouse

<400>  83

Met Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  84
<211>  8
<212>  PRT
<213>  mouse

<400>  84

Arg Gly Asp Tyr Asn Phe Asp Tyr 
1               5               


<210>  85
<211>  17
<212>  PRT
<213>  mouse

<400>  85

Arg Ile Tyr Pro Gly Thr Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  86
<211>  12
<212>  PRT
<213>  mouse

<400>  86

Gly Glu Asp Asn Leu Tyr Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  87
<211>  5
<212>  PRT
<213>  mouse

<400>  87

Glu Tyr Thr Met His 
1               5   


<210>  88
<211>  17
<212>  PRT
<213>  mouse

<400>  88

Gly Ile Asn Pro Asn Ile Val Asp Thr Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  89
<211>  11
<212>  PRT
<213>  mouse

<400>  89

Asp Gly Tyr Pro Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  90
<211>  5
<212>  PRT
<213>  mouse

<400>  90

Asp Tyr Asn Met Asp 
1               5   


<210>  91
<211>  17
<212>  PRT
<213>  mouse

<400>  91

Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  92
<211>  9
<212>  PRT
<213>  mouse

<400>  92

Glu Gly Tyr Gly Asn Tyr Phe Asp Tyr 
1               5                   


<210>  93
<211>  17
<212>  PRT
<213>  mouse

<400>  93

Asp Ile Asn Pro Asn Asn Gly Phe Thr Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  94
<211>  5
<212>  PRT
<213>  mouse

<400>  94

Asp His Ala Ile His 
1               5   


<210>  95
<211>  17
<212>  PRT
<213>  mouse

<400>  95

Tyr Ile Ser Pro Gly Asn Gly Asp Ile Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  96
<211>  10
<212>  PRT
<213>  mouse

<400>  96

Asp Asp Gly Phe Tyr Pro Trp Phe Val Tyr 
1               5                   10  


<210>  97
<211>  5
<212>  PRT
<213>  mouse

<400>  97

Ser His Ser Ile His 
1               5   


<210>  98
<211>  17
<212>  PRT
<213>  mouse

<400>  98

Ala Val Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Tyr Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  99
<211>  11
<212>  PRT
<213>  mouse

<400>  99

Asp Gly Tyr Ser Asp Tyr Tyr Ala Met Asp Cys 
1               5                   10      


<210>  100
<211>  5
<212>  PRT
<213>  mouse

<400>  100

Asp Tyr Tyr Met His 
1               5   


<210>  101
<211>  17
<212>  PRT
<213>  mouse

<400>  101

Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Leu 
1               5                   10                  15      


Gly 
    


<210>  102
<211>  8
<212>  PRT
<213>  mouse

<400>  102

Trp Tyr Tyr Tyr Ala Met Asp Ser 
1               5               


<210>  103
<211>  9
<212>  PRT
<213>  mouse

<400>  103

Pro Ser Ala Thr Ser Tyr Phe Asp Tyr 
1               5                   


<210>  104
<211>  17
<212>  PRT
<213>  mouse

<400>  104

Gly Ile Asn Pro Asn Asn Gly Asp Thr Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


