                         SEQUENCE LISTING

<110>  PROVIDENCE HEALTH & SERVICES - OREGON
 
<120>  T CELL RECEPTORS SPECIFIC FOR A MUTANT FORM OF THE RET ONCOGENE 
       AND USES THEREOF

<130>  6727-105223-02

<150>  US 63/117,859
<151>  2020-11-24

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  394
<212>  DNA
<213>  Homo sapiens

<400>  1
atgaactatt ctccaggctt agtatctctg atactcttac tgcttggaag aacccgtgga       60

aattcagtga cccagatgga agggccagtg actctctcag aagaggcctt cctgactata      120

aactgcacgt acacagccac aggataccct tcccttttct ggtatgtcca atatcctgga      180

gaaggtctac agctcctcct gaaagccacg aaggctgatg acaagggaag caacaaaggt      240

tttgaagcca cataccgtaa agaaaccact tctttccact tggagaaagg ctcagttcaa      300

gtgtcagact cagcggtgta cttctgtgct ctgagtgaga acgccggtaa ccagttctat      360

tttgggacag ggacaagttt gacggtcatt ccaa                                  394


<210>  2
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asn Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser 
            100                 105                 110         


Glu Asn Ala Gly Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr 
        115                 120                 125             


Val Ile Pro 
    130     


<210>  3
<211>  388
<212>  DNA
<213>  Homo sapiens

<400>  3
atgagcatcg gcctcctgtg ctgtgcagcc ttgtctctcc tgtgggcagg tccagtgaat       60

gctggtgtca ctcagacccc aaaattccag gtcctgaaga caggacagag catgacactg      120

cagtgtgccc aggatatgaa ccatgaatac atgtcctggt atcgacaaga cccaggcatg      180

gggctgaggc tgattcatta ctcagttggt gctggtatca ctgaccaagg agaagtcccc      240

aatggctaca atgtctccag atcaaccaca gaggatttcc cgctcaggct gctgtcggct      300

gctccctccc agacatctgt gtacttctgt gccagcagcc gagggaatac gcagtatttt      360

ggcccaggca cccggctgac agtgctcg                                         388


<210>  4
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Arg Gly Asn Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Leu 
    


<210>  5
<211>  403
<212>  DNA
<213>  Homo sapiens

<400>  5
atgtcacttt ctagcctgct gaaggtggtc acagcttcac tgtggctagg acctggcatt       60

gcccagaaga taactcaaac ccaaccagga atgttcgtgc aggaaaagga ggctgtgact      120

ctggactgca catatgacac cagtgatcaa agttatggtc tattctggta caagcagccc      180

agcagtgggg aaatgatttt tcttatttat caggggtctt atgacgagca aaatgcaaca      240

gaaggtcgct actcattgaa tttccagaag gcaagaaaat ccgccaacct tgtcatctcc      300

gcttcacaac tgggggactc agcaatgtat ttctgtgcaa tgagagaggg cgatggtgat      360

gacatgcgct ttggagcagg gaccagactg acagtaaaac caa                        403


<210>  6
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Gln Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Arg Glu Gly Asp Gly Asp Asp Met Arg Phe Gly Ala Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Lys Pro 
    130                 


<210>  7
<211>  409
<212>  DNA
<213>  Homo sapiens

<400>  7
atggatacct ggctcgtatg ctgggcaatt tttagtctct tgaaagcagg actcacagaa       60

cctgaagtca cccagactcc cagccatcag gtcacacaga tgggacagga agtgatcttg      120

cgctgtgtcc ccatctctaa tcacttatac ttctattggt acagacaaat cttggggcag      180

aaagtcgagt ttctggtttc cttttataat aatgaaatct cagagaagtc tgaaatattc      240

gatgatcaat tctcagttga aaggcctgat ggatcaaatt tcactctgaa gatccggtcc      300

acaaagctgg aggactcagc catgtacttc tgtgccagca gttctcagat tcagacggtc      360

atgaacactg aagctttctt tggacaaggc accagactca cagttgtag                  409


<210>  8
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Leu Arg Cys Val Pro Ile Ser Asn His Leu 
        35                  40                  45              


Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe Leu 
    50                  55                  60                  


Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe Asp 
65                  70                  75                  80  


Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu Lys 
                85                  90                  95      


Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Ser Gln Ile Gln Thr Val Met Asn Thr Glu Ala Phe Phe Gly Gln 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Val 
    130                 135 


<210>  9
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  9

Val Lys Arg Ser Gln Gly Arg Ile Pro Val Lys Trp Met Ala Ile Glu 
1               5                   10                  15      


Ser Leu Phe Asp His Ile Tyr Thr Thr 
            20                  25  


<210>  10
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  10

Val Lys Arg Ser Gln Gly Arg Ile Pro Val Lys Trp Thr Ala Ile Glu 
1               5                   10                  15      


Ser Leu Phe Asp His Ile Tyr Thr Thr 
            20                  25  


<210>  11
<211>  1114
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg 
            100                 105                 110         


Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser 
        115                 120                 125             


Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu 
145                 150                 155                 160 


Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu 
        195                 200                 205             


Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val 
225                 230                 235                 240 


Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val 
                245                 250                 255     


Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe 
            260                 265                 270         


Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro 
305                 310                 315                 320 


Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn 
                325                 330                 335     


Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His 
            340                 345                 350         


Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg 
        355                 360                 365             


Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala 
                405                 410                 415     


Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala 
            420                 425                 430         


Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn 
        435                 440                 445             


Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile 
    450                 455                 460                 


Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu 
465                 470                 475                 480 


Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala 
                485                 490                 495     


Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu 
            500                 505                 510         


Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly 
            580                 585                 590         


Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr 
        595                 600                 605             


Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys 
                645                 650                 655     


Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro 
705                 710                 715                 720 


Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                725                 730                 735     


Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr 
            740                 745                 750         


Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His 
    770                 775                 780                 


Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
785                 790                 795                 800 


Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                805                 810                 815     


Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser 
            820                 825                 830         


Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met 
        835                 840                 845             


Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr 
    850                 855                 860                 


Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
865                 870                 875                 880 


Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                885                 890                 895     


Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg 
            900                 905                 910         


Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
        915                 920                 925             


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
    930                 935                 940                 


Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
945                 950                 955                 960 


Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                965                 970                 975     


Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
            980                 985                 990         


Asp Lys Arg Pro Val Phe Ala Asp  Ile Ser Lys Asp Leu  Glu Lys Met 
        995                 1000                 1005             


Met Val  Lys Arg Arg Asp Tyr  Leu Asp Leu Ala Ala  Ser Thr Pro 
    1010                 1015                 1020             


Ser Asp  Ser Leu Ile Tyr Asp  Asp Gly Leu Ser Glu  Glu Glu Thr 
    1025                 1030                 1035             


Pro Leu  Val Asp Cys Asn Asn  Ala Pro Leu Pro Arg  Ala Leu Pro 
    1040                 1045                 1050             


Ser Thr  Trp Ile Glu Asn Lys  Leu Tyr Gly Met Ser  Asp Pro Asn 
    1055                 1060                 1065             


Trp Pro  Gly Glu Ser Pro Val  Pro Leu Thr Arg Ala  Asp Gly Thr 
    1070                 1075                 1080             


Asn Thr  Gly Phe Pro Arg Tyr  Pro Asn Asp Ser Val  Tyr Ala Asn 
    1085                 1090                 1095             


Trp Met  Leu Ser Pro Ser Ala  Ala Lys Leu Met Asp  Thr Phe Asp 
    1100                 1105                 1110             


Ser 
    


<210>  12
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Asn or Asp

<400>  12

Xaa Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  13
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  14
<211>  173
<212>  PRT
<213>  Mus musculus

<400>  14

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
                165                 170             


<210>  15
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<400>  15

Xaa Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys 
1               5                   10                  15      


Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr 
            20                  25                  30          


Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala 
    50                  55                  60                  


Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser 
65                  70                  75                  80  


Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp 
                85                  90                  95      


Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe 
            100                 105                 110         


Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala 
        115                 120                 125             


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140     


<210>  16
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     


<210>  17
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  17

Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     


Ser Arg Gly 
            


<210>  18
<211>  421
<212>  DNA
<213>  Homo sapiens

<400>  18
atggccatgc tcctgggggc atcagtgctg attctgtggc ttcagccaga ctgggtaaac       60

agtcaacaga agaatgatga ccagcaagtt aagcaaaatt caccatccct gagcgtccag      120

gaaggaagaa tttctattct gaactgtgac tatactaaca gcatgtttga ttatttccta      180

tggtacaaaa aataccctgc tgaaggtcct acattcctga tatctataag ttccattaag      240

gataaaaatg aagatggaag attcactgtc ttcttaaaca aaagtgccaa gcacctctct      300

ctgcacattg tgccctccca gcctggagac tctgcagtgt acttctgtgc agcaagcggc      360

catggaggaa gccaaggaaa tctcatcttt ggaaaaggca ctaaactctc tgttaaacca      420

a                                                                      421


<210>  19
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro 
1               5                   10                  15      


Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln 
            20                  25                  30          


Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn 
        35                  40                  45              


Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys 
    50                  55                  60                  


Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys 
65                  70                  75                  80  


Asp Lys Asn Glu Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala 
                85                  90                  95      


Lys His Leu Ser Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Ala Ser Gly His Gly Gly Ser Gln Gly Asn Leu 
        115                 120                 125             


Ile Phe Gly Lys Gly Thr Lys Leu Ser Val Lys Pro 
    130                 135                 140 


<210>  20
<211>  409
<212>  DNA
<213>  Homo sapiens

<400>  20
atgggcacca ggctcctctg ctgggtggtc ctgggtttcc tagggacaga tcacacaggt       60

gctggagtct cccagtcccc taggtacaaa gtcgcaaaga gaggacagga tgtagctctc      120

aggtgtgatc caatttcggg tcatgtatcc cttttttggt accaacaggc cctggggcag      180

gggccagagt ttctgactta tttccagaat gaagctcaac tagacaaatc ggggctgccc      240

agtgatcgct tctttgcaga aaggcctgag ggatccgtct ccactctgaa gatccagcgc      300

acacagcagg aggactccgc cgtgtatctc tgtgccagca gcttaaggtt tttgggacag      360

ggctcctacg agcagtactt cgggccgggc accaggctca cggtcacag                  409


<210>  21
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly Thr Arg Leu Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Ala 
            20                  25                  30          


Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Val Ser Leu Phe Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Phe Ala Glu Arg Pro Glu Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Arg Phe Leu Gly Gln Gly Ser Tyr Glu Gln Tyr Phe Gly 
        115                 120                 125             


Pro Gly Thr Arg Leu Thr Val Thr 
    130                 135     


