                         SEQUENCE LISTING

<110>  RAMOT AT TEL-AVIV UNIVERSITY LTD.
 
<120>  HUMANIZED ANTIBODIES AND FRAGMENTS THEREOF BINDING TO 
       CARBOHYDRATE ANTIGENS AND USES THEREOF

<130>  RAMOT-0103 PCT

<150>  63117493
<151>  2020-11-24

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  1

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Gly Asn Lys Gly Asn Asn His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser Lys Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Gly Thr Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  2
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  2

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  3

Lys Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Gly Asn Lys Gly Asn Asn His Ala Thr Asn Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser Lys Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Gly Thr Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Arg Phe Ala Tyr Trp Gly Gln Gly Thr Pro Val Thr 
            100                 105                 110         


Val Pro Ala 
        115 


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  4

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Pro Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  5

Asp Ala Trp Met Asp 
1               5   


<210>  6
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  6

Glu Ile Gly Asn Lys Gly Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  7

Arg Phe Ala Tyr 
1               


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  8

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  9

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  10

Leu Gln Tyr Asp Glu Phe Pro Arg Thr Phe 
1               5                   10  


<210>  11
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  11

Glu Ile Gly Asn Lys Gly Asn Asn His Ala Thr Asn Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  12
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Gly Asn Lys Gly Asn Asn His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  13
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  14
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Gly Asn Lys Gly Asn Asn His Ala Thr Asn Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Arg Phe Ala Tyr Trp Gly Gln Gly Thr Pro Val Thr 
            100                 105                 110         


Val Pro Ser 
        115 


<210>  15
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Pro Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  16
<211>  345
<212>  DNA
<213>  Homo sapiens

<400>  16
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gatgcctgga tggattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttgccgaa attggtaaca agggcaataa tcacgccacg      180

tactatgccg agtctgtaaa aggaagattc accatctcaa gagatgattc aaagaactca      240

ctgtatctgc aaatgaacag cctgaaaacc gaggacacgg ccgtgtatta ctgtaccact      300

aggtttgcat attggggcca aggaaccctg gtcaccgtct cctca                      345


<210>  17
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  17
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aggcatccca agatatcaac tcatacttga gttggttcca gcagaaacca      120

gggaaagccc ctaagctcct gatctaccgt gccaataggc ttgtggatgg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtttacag tatgatgagt ttccacgtac ttttggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  18
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  18
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gatgcctgga tggattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttgccgaa attggtaaca agggcaataa tcacgccacg      180

aactatgccg agtctgtaaa aggaagattc accatctcaa gagatgattc aaagaactca      240

ctgtatctgc aaatgaacag cctgaaaacc gaggacacgg ccgtgtatta ctgtaccact      300

aggtttgcat attggggcca aggaaccccg gtcaccgtcc cttca                      345


<210>  19
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  19
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcccttgca aggcatccca agatatcaac tcatacttga gttggttcca gcagaaacca      120

gggaaagccc ctaagctcct gatctaccgt gccaataggc ttgtggatgg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtttacag tatgatgagt ttccacgtac ttttggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  20

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  21
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  21
ggaggtggcg gtagcggagg cggcggttct ggaggtggcg ggagc                       45


<210>  22
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Gly Asn Lys Gly Asn Asn His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
    130                 135                 140                 


Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn 
145                 150                 155                 160 


Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
                165                 170                 175     


Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu 
        195                 200                 205             


Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe 
    210                 215                 220                 


Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235         


<210>  23
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Gly Asn Lys Gly Asn Asn His Ala Thr Asn Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Arg Phe Ala Tyr Trp Gly Gln Gly Thr Pro Val Thr 
            100                 105                 110         


Val Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
    130                 135                 140                 


Val Gly Asp Arg Val Thr Ile Pro Cys Lys Ala Ser Gln Asp Ile Asn 
145                 150                 155                 160 


Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
                165                 170                 175     


Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu 
        195                 200                 205             


Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe 
    210                 215                 220                 


Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235         


<210>  24
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  25

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  26
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  26

Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Thr 
            20                  25                  30          


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  27

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  28
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  29
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  29

Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  30
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  30

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  31

Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  32

Trp Gly Gln Gly Thr Pro Val Thr Val Pro Ser 
1               5                   10      


<210>  33
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  33

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Pro Cys 
            20              


<210>  34
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  34

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Gly Asn Lys Gly Asn Asn His Ala Thr Asn Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser Lys Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Gly Thr Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  35

Gly Gly Gly Gly Ser 
1               5   


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  36

Gly Phe Thr Phe Ser Asp Ala Trp Met Asp 
1               5                   10  


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  37

Asn Lys Gly Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser Val Lys Gly 
1               5                   10                  15      


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  38

Asn Lys Gly Asn Asn His Ala Thr Asn Tyr Ala Glu Ser Val Lys Gly 
1               5                   10                  15      


