                         SEQUENCE LISTING

<110>  Cancer Research Technology Ltd
 
<120>  NUCLEIC ACID CONSTRUCTS AND CELLS

<130>  P307835WO

<150>  GB2018554.2
<151>  2020-11-25

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  629
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Cys Lys Val Leu Leu Asn Ile Gly Gln Gln Met Leu Arg Arg 
1               5                   10                  15      


Lys Val Val Asp Cys Ser Arg Glu Glu Thr Arg Leu Ser Arg Cys Leu 
            20                  25                  30          


Asn Thr Phe Asp Leu Val Ala Leu Gly Val Gly Ser Thr Leu Gly Ala 
        35                  40                  45              


Gly Val Tyr Val Leu Ala Gly Ala Val Ala Arg Glu Asn Ala Gly Pro 
    50                  55                  60                  


Ala Ile Val Ile Ser Phe Leu Ile Ala Ala Leu Ala Ser Val Leu Ala 
65                  70                  75                  80  


Gly Leu Cys Tyr Gly Glu Phe Gly Ala Arg Val Pro Lys Thr Gly Ser 
                85                  90                  95      


Ala Tyr Leu Tyr Ser Tyr Val Thr Val Gly Glu Leu Trp Ala Phe Ile 
            100                 105                 110         


Thr Gly Trp Asn Leu Ile Leu Ser Tyr Ile Ile Gly Thr Ser Ser Val 
        115                 120                 125             


Ala Arg Ala Trp Ser Ala Thr Phe Asp Glu Leu Ile Gly Arg Pro Ile 
    130                 135                 140                 


Gly Glu Phe Ser Arg Thr His Met Thr Leu Asn Ala Pro Gly Val Leu 
145                 150                 155                 160 


Ala Glu Asn Pro Asp Ile Phe Ala Val Ile Ile Ile Leu Ile Leu Thr 
                165                 170                 175     


Gly Leu Leu Thr Leu Gly Val Lys Glu Ser Ala Met Val Asn Lys Ile 
            180                 185                 190         


Phe Thr Cys Ile Asn Val Leu Val Leu Gly Phe Ile Met Val Ser Gly 
        195                 200                 205             


Phe Val Lys Gly Ser Val Lys Asn Trp Gln Leu Thr Glu Glu Asp Phe 
    210                 215                 220                 


Gly Asn Thr Ser Gly Arg Leu Cys Leu Asn Asn Asp Thr Lys Glu Gly 
225                 230                 235                 240 


Lys Pro Gly Val Gly Gly Phe Met Pro Phe Gly Phe Ser Gly Val Leu 
                245                 250                 255     


Ser Gly Ala Ala Thr Cys Phe Tyr Ala Phe Val Gly Phe Asp Cys Ile 
            260                 265                 270         


Ala Thr Thr Gly Glu Glu Val Lys Asn Pro Gln Lys Ala Ile Pro Val 
        275                 280                 285             


Gly Ile Val Ala Ser Leu Leu Ile Cys Phe Ile Ala Tyr Phe Gly Val 
    290                 295                 300                 


Ser Ala Ala Leu Thr Leu Met Met Pro Tyr Phe Cys Leu Asp Asn Asn 
305                 310                 315                 320 


Ser Pro Leu Pro Asp Ala Phe Lys His Val Gly Trp Glu Gly Ala Lys 
                325                 330                 335     


Tyr Ala Val Ala Val Gly Ser Leu Cys Ala Leu Ser Ala Ser Leu Leu 
            340                 345                 350         


Gly Ser Met Phe Pro Met Pro Arg Val Ile Tyr Ala Met Ala Glu Asp 
        355                 360                 365             


Gly Leu Leu Phe Lys Phe Leu Ala Asn Val Asn Asp Arg Thr Lys Thr 
    370                 375                 380                 


Pro Ile Ile Ala Thr Leu Ala Ser Gly Ala Val Ala Ala Val Met Ala 
385                 390                 395                 400 


Phe Leu Phe Asp Leu Lys Asp Leu Val Asp Leu Met Ser Ile Gly Thr 
                405                 410                 415     


Leu Leu Ala Tyr Ser Leu Val Ala Ala Cys Val Leu Val Leu Arg Tyr 
            420                 425                 430         


Gln Pro Glu Gln Pro Asn Leu Val Tyr Gln Met Ala Ser Thr Ser Asp 
        435                 440                 445             


Glu Leu Asp Pro Ala Asp Gln Asn Glu Leu Ala Ser Thr Asn Asp Ser 
    450                 455                 460                 


Gln Leu Gly Phe Leu Pro Glu Ala Glu Met Phe Ser Leu Lys Thr Ile 
465                 470                 475                 480 


Leu Ser Pro Lys Asn Met Glu Pro Ser Lys Ile Ser Gly Leu Ile Val 
                485                 490                 495     


Asn Ile Ser Thr Ser Leu Ile Ala Val Leu Ile Ile Thr Phe Cys Ile 
            500                 505                 510         


Val Thr Val Leu Gly Arg Glu Ala Leu Thr Lys Gly Ala Leu Trp Ala 
        515                 520                 525             


Val Phe Leu Leu Ala Gly Ser Ala Leu Leu Cys Ala Val Val Thr Gly 
    530                 535                 540                 


Val Ile Trp Arg Gln Pro Glu Ser Lys Thr Lys Leu Ser Phe Lys Val 
545                 550                 555                 560 


Pro Phe Leu Pro Val Leu Pro Ile Leu Ser Ile Phe Val Asn Val Tyr 
                565                 570                 575     


Leu Met Met Gln Leu Asp Gln Gly Thr Trp Val Arg Phe Ala Val Trp 
            580                 585                 590         


Met Leu Ile Gly Phe Ile Ile Tyr Phe Gly Tyr Gly Leu Trp His Ser 
        595                 600                 605             


Glu Glu Ala Ser Leu Asp Ala Asp Gln Ala Arg Thr Pro Asp Gly Asn 
    610                 615                 620                 


Leu Asp Gln Cys Lys 
625                 


<210>  2
<211>  1890
<212>  DNA
<213>  Homo sapiens

<400>  2
atggggtgca aagtcctgct caacattggg cagcagatgc tgcggcggaa ggtggtggac       60

tgtagccggg aggagacgcg gctgtctcgc tgcctgaaca cttttgatct ggtggccctc      120

ggggtgggca gcacactggg tgctggtgtc tacgtcctgg ctggagctgt ggcccgtgag      180

aatgcaggcc ctgccattgt catctccttc ctgatcgctg cgctggcctc agtgctggct      240

ggcctgtgct atggcgagtt tggtgctcgg gtccccaaga cgggctcagc ttacctctac      300

agctatgtca ccgttggaga gctctgggcc ttcatcaccg gctggaactt aatcctctcc      360

tacatcatcg gtacttcaag cgtagcgagg gcctggagcg ccaccttcga cgagctgata      420

ggcagaccca tcggggagtt ctcacggaca cacatgactc tgaacgcccc cggcgtgctg      480

gctgaaaacc ccgacatatt cgcagtgatc ataattctca tcttgacagg acttttaact      540

cttggtgtga aagagtcggc catggtcaac aaaatattca cttgtattaa cgtcctggtc      600

ctgggcttca taatggtgtc aggatttgtg aaaggatcgg ttaaaaactg gcagctcacg      660

gaggaggatt ttgggaacac atcaggccgt ctctgtttga acaatgacac aaaagaaggg      720

aagcccggtg ttggtggatt catgcccttc gggttctctg gtgtcctgtc gggggcagcg      780

acttgcttct atgccttcgt gggctttgac tgcatcgcca ccacaggtga agaggtgaag      840

aacccacaga aggccatccc cgtggggatc gtggcgtccc tcttgatctg cttcatcgcc      900

tactttgggg tgtcggctgc cctcacgctc atgatgccct acttctgcct ggacaataac      960

agccccctgc ccgacgcctt taagcacgtg ggctgggaag gtgccaagta cgcagtggcc     1020

gtgggctccc tctgcgctct ttccgccagt cttctaggtt ccatgtttcc catgcctcgg     1080

gttatctatg ccatggctga ggatggactg ctatttaaat tcttagccaa cgtcaatgat     1140

aggaccaaaa caccaataat cgccacatta gcctcgggtg ccgttgctgc tgtgatggcc     1200

ttcctctttg acctgaagga cttggtggac ctcatgtcca ttggcactct cctggcttac     1260

tcgttggtgg ctgcctgtgt gttggtctta cggtaccagc cagagcagcc taacctggta     1320

taccagatgg ccagtacttc cgacgagtta gatccagcag accaaaatga attggcaagc     1380

accaatgatt cccagctggg ctttttacca gaggcagaga tgttctcttt gaaaaccata     1440

ctctcaccca aaaacatgga gccttccaaa atctctgggc taattgtgaa catttcaacc     1500

agcctcatag ctgttctcat catcaccttc tgcattgtga ccgtgcttgg aagggaggct     1560

ctcaccaaag gggcgctgtg ggcagtcttt ctgctcgcag ggtctgccct cctctgtgcc     1620

gtggtcacgg gcgtcatctg gaggcagccc gagagcaaga ccaagctctc atttaaggtt     1680

cccttcctgc cagtgctccc catcctgagc atcttcgtga acgtctatct catgatgcag     1740

ctggaccagg gcacctgggt ccggtttgct gtgtggatgc tgataggctt catcatctac     1800

tttggctatg gcctgtggca cagcgaggag gcgtccctgg atgccgacca agcaaggact     1860

cctgacggca acttggacca gtgcaagtga                                      1890


<210>  3
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Gly Ala Gly Pro Lys Arg Arg Ala Leu Ala Ala Pro Ala Ala 
1               5                   10                  15      


Glu Glu Lys Glu Glu Ala Arg Glu Lys Met Leu Ala Ala Lys Ser Ala 
            20                  25                  30          


Asp Gly Ser Ala Pro Ala Gly Glu Gly Glu Gly Val Thr Leu Gln Arg 
        35                  40                  45              


Asn Ile Thr Leu Leu Asn Gly Val Ala Ile Ile Val Gly Thr Ile Ile 
    50                  55                  60                  


Gly Ser Gly Ile Phe Val Thr Pro Thr Gly Val Leu Lys Glu Ala Gly 
65                  70                  75                  80  


Ser Pro Gly Leu Ala Leu Val Val Trp Ala Ala Cys Gly Val Phe Ser 
                85                  90                  95      


Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr Ile Ser Lys 
            100                 105                 110         


Ser Gly Gly Asp Tyr Ala Tyr Met Leu Glu Val Tyr Gly Ser Leu Pro 
        115                 120                 125             


Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu Ile Ile Arg Pro Ser Ser 
    130                 135                 140                 


Gln Tyr Ile Val Ala Leu Val Phe Ala Thr Tyr Leu Leu Lys Pro Leu 
145                 150                 155                 160 


Phe Pro Thr Cys Pro Val Pro Glu Glu Ala Ala Lys Leu Val Ala Cys 
                165                 170                 175     


Leu Cys Val Leu Leu Leu Thr Ala Val Asn Cys Tyr Ser Val Lys Ala 
            180                 185                 190         


Ala Thr Arg Val Gln Asp Ala Phe Ala Ala Ala Lys Leu Leu Ala Leu 
        195                 200                 205             


Ala Leu Ile Ile Leu Leu Gly Phe Val Gln Ile Gly Lys Gly Asp Val 
    210                 215                 220                 


Ser Asn Leu Asp Pro Asn Phe Ser Phe Glu Gly Thr Lys Leu Asp Val 
225                 230                 235                 240 


Gly Asn Ile Val Leu Ala Leu Tyr Ser Gly Leu Phe Ala Tyr Gly Gly 
                245                 250                 255     


Trp Asn Tyr Leu Asn Phe Val Thr Glu Glu Met Ile Asn Pro Tyr Arg 
            260                 265                 270         


Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu Pro Ile Val Thr Leu Val 
        275                 280                 285             


Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr Thr Leu Ser Thr Glu Gln 
    290                 295                 300                 


Met Leu Ser Ser Glu Ala Val Ala Val Asp Phe Gly Asn Tyr His Leu 
305                 310                 315                 320 


Gly Val Met Ser Trp Ile Ile Pro Val Phe Val Gly Leu Ser Cys Phe 
                325                 330                 335     


Gly Ser Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu Phe Phe Val 
            340                 345                 350         


Gly Ser Arg Glu Gly His Leu Pro Ser Ile Leu Ser Met Ile His Pro 
        355                 360                 365             


Gln Leu Leu Thr Pro Val Pro Ser Leu Val Phe Thr Cys Val Met Thr 
    370                 375                 380                 


Leu Leu Tyr Ala Phe Ser Lys Asp Ile Phe Ser Val Ile Asn Phe Phe 
385                 390                 395                 400 


Ser Phe Phe Asn Trp Leu Cys Val Ala Leu Ala Ile Ile Gly Met Ile 
                405                 410                 415     


Trp Leu Arg His Arg Lys Pro Glu Leu Glu Arg Pro Ile Lys Val Asn 
            420                 425                 430         


Leu Ala Leu Pro Val Phe Phe Ile Leu Ala Cys Leu Phe Leu Ile Ala 
        435                 440                 445             


Val Ser Phe Trp Lys Thr Pro Val Glu Cys Gly Ile Gly Phe Thr Ile 
    450                 455                 460                 


Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe Gly Val Trp Trp Lys Asn 
465                 470                 475                 480 


Lys Pro Lys Trp Leu Leu Gln Gly Ile Phe Ser Thr Thr Val Leu Cys 
                485                 490                 495     


Gln Lys Leu Met Gln Val Val Pro Gln Glu Thr 
            500                 505         


<210>  4
<211>  1524
<212>  DNA
<213>  Homo sapiens

<400>  4
atggcgggtg cgggcccgaa gcggcgcgcg ctagcggcgc cggcggccga ggagaaggaa       60

gaggcgcggg agaagatgct ggccgccaag agcgcggacg gctcggcgcc ggcaggcgag      120

ggcgagggcg tgaccctgca gcggaacatc acgctgctca acggcgtggc catcatcgtg      180

gggaccatta tcggctcggg catcttcgtg acgcccacgg gcgtgctcaa ggaggcaggc      240

tcgccggggc tggcgctggt ggtgtgggcc gcgtgcggcg tcttctccat cgtgggcgcg      300

ctctgctacg cggagctcgg caccaccatc tccaaatcgg gcggcgacta cgcctacatg      360

ctggaggtct acggctcgct gcccgccttc ctcaagctct ggatcgagct gctcatcatc      420

cggccttcat cgcagtacat cgtggccctg gtcttcgcca cctacctgct caagccgctc      480

ttccccacct gcccggtgcc cgaggaggca gccaagctcg tggcctgcct ctgcgtgctg      540

ctgctcacgg ccgtgaactg ctacagcgtg aaggccgcca cccgggtcca ggatgccttt      600

gccgccgcca agctcctggc cctggccctg atcatcctgc tgggcttcgt ccagatcggg      660

aagggtgatg tgtccaatct agatcccaac ttctcatttg aaggcaccaa actggatgtg      720

gggaacattg tgctggcatt atacagcggc ctctttgcct atggaggatg gaattacttg      780

aatttcgtca cagaggaaat gatcaacccc tacagaaacc tgcccctggc catcatcatc      840

tccctgccca tcgtgacgct ggtgtacgtg ctgaccaacc tggcctactt caccaccctg      900

tccaccgagc agatgctgtc gtccgaggcc gtggccgtgg acttcgggaa ctatcacctg      960

ggcgtcatgt cctggatcat ccccgtcttc gtgggcctgt cctgcttcgg ctccgtcaat     1020

gggtccctgt tcacatcctc caggctcttc ttcgtggggt cccgggaagg ccacctgccc     1080

tccatcctct ccatgatcca cccacagctc ctcacccccg tgccgtccct cgtgttcacg     1140

tgtgtgatga cgctgctcta cgccttctcc aaggacatct tctccgtcat caacttcttc     1200

agcttcttca actggctctg cgtggccctg gccatcatcg gcatgatctg gctgcgccac     1260

agaaagcctg agcttgagcg gcccatcaag gtgaacctgg ccctgcctgt gttcttcatc     1320

ctggcctgcc tcttcctgat cgccgtctcc ttctggaaga cacccgtgga gtgtggcatc     1380

ggcttcacca tcatcctcag cgggctgccc gtctacttct tcggggtctg gtggaaaaac     1440

aagcccaagt ggctcctcca gggcatcttc tccacgaccg tcctgtgtca gaagctcatg     1500

caggtggtcc cccaggagac atag                                            1524


<210>  5
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 
1               5                   10                  15      


Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 
            20                  25                  30          


Ala Gly Asp Asp Ser Glu Leu Gly Ser His Cys Val Ala Gln Thr Gly 
        35                  40                  45              


Leu Glu Leu Leu Ala Ser Gly Asp Pro Leu Pro Ser Ala Ser Gln Asn 
    50                  55                  60                  


Ala Glu Met Ile Glu Thr Gly Ser Asp Cys Val Thr Gln Ala Gly Leu 
65                  70                  75                  80  


Gln Leu Leu Ala Ser Ser Asp Pro Pro Ala Leu Ala Ser Lys Asn Ala 
                85                  90                  95      


Glu Val Thr Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu 
            100                 105                 110         


Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala 
        115                 120                 125             


Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val 
    130                 135                 140                 


Lys Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys 
145                 150                 155                 160 


Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro 
                165                 170                 175     


Gly Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly 
            180                 185                 190         


Trp Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro 
        195                 200                 205             


Arg Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu 
    210                 215                 220                 


Tyr Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn 
225                 230                 235                 240 


Leu Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val 
                245                 250                 255     


Lys Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val 
            260                 265                 270         


Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu 
        275                 280                 285             


Asp Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val 
    290                 295                 300                 


Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser 
305                 310                 315                 320 


Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe 
                325                 330                 335     


Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn 
            340                 345                 350         


Leu Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys 
        355                 360                 365             


Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp 
    370                 375                 380                 


Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu 
385                 390                 395                 400 


Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys 
                405                 410                 415     


Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser 
            420                 425                 430         


Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln 
        435                 440                 445             


Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro 
    450                 455                 460                 


Val Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro 
465                 470                 475                 480 


Gly Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe 
                485                 490                 495     


Pro Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln 
            500                 505                 510         


Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp 
        515                 520                 525             


Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His Ala Phe 
    530                 535                 540                 


Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn 
545                 550                 555                 560 


Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala 
                565                 570                 575     


Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys 
            580                 585                 590         


Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro 
        595                 600                 605             


Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu 
    610                 615                 620                 


Arg Phe Pro Tyr Ala Ala 
625                 630 


<210>  6
<211>  1896
<212>  DNA
<213>  Homo sapiens

<400>  6
atggagctac agcctcctga agcctcgatc gccgtcgtgt cgattccgcg ccagttgcct       60

ggctcacatt cggaggctgg tgtccagggt ctcagcgcgg gggacgactc agagacgggg      120

tctgactgtg ttacccaggc tggtcttcaa ctcttggcct caagtgatcc tcctgcctta      180

gcttccaaga atgctgaggt tacagtagaa acggggtttc accatgttag ccaggctgat      240

attgaattcc tgacctcaat tgatccgact gcctcggcct ccggaagtgc tgggattaca      300

ggcaccatga gccaggacac cgaggtggat atgaaggagg tggagctgaa tgagttagag      360

cccgagaagc agccgatgaa cgcggcgtct ggggcggcca tgtccctggc gggagccgag      420

aagaatggtc tggtgaagat caaggtggcg gaagacgagg cggaggcggc agccgcggct      480

aagttcacgg gcctgtccaa ggaggagctg ctgaaggtgg caggcagccc cggctgggta      540

cgcacccgct gggcactgct gctgctcttc tggctcggct ggctcggcat gcttgctggt      600

gccgtggtca taatcgtgcg agcgccgcgt tgtcgcgagc taccggcgca gaagtggtgg      660

cacacgggcg ccctctaccg catcggcgac cttcaggcct tccagggcca cggcgcgggc      720

aacctggcgg gtctgaaggg gcgtctcgat tacctgagct ctctgaaggt gaagggcctt      780

gtgctgggtc caattcacaa gaaccagaag gatgatgtcg ctcagactga cttgctgcag      840

atcgacccca attttggctc caaggaagat tttgacagtc tcttgcaatc ggctaaaaaa      900

aagagcatcc gtgtcattct ggaccttact cccaactacc ggggtgagaa ctcgtggttc      960

tccactcagg ttgacactgt ggccaccaag gtgaaggatg ctctggagtt ttggctgcaa     1020

gctggcgtgg atgggttcca ggttcgggac atagagaatc tgaaggatgc atcctcattc     1080

ttggctgagt ggcaaaatat caccaagggc ttcagtgaag acaggctctt gattgcgggg     1140

actaactcct ccgaccttca gcagatcctg agcctactcg aatccaacaa agacttgctg     1200

ttgactagct catacctgtc tgattctggt tctactgggg agcatacaaa atccctagtc     1260

acacagtatt tgaatgccac tggcaatcgc tggtgcagct ggagtttgtc tcaggcaagg     1320

ctcctgactt ccttcttgcc ggctcaactt ctccgactct accagctgat gctcttcacc     1380

ctgccaggga cccctgtttt cagctacggg gatgagattg gcctggatgc agctgccctt     1440

cctggacagc ctatggaggc tccagtcatg ctgtgggatg agtccagctt ccctgacatc     1500

ccaggggctg taagtgccaa catgactgtg aagggccaga gtgaagaccc tggctccctc     1560

ctttccttgt tccggcggct gagtgaccag cggagtaagg agcgctccct actgcatggg     1620

gacttccacg cgttctccgc tgggcctgga ctcttctcct atatccgcca ctgggaccag     1680

aatgagcgtt ttctggtagt gcttaacttt ggggatgtgg gcctctcggc tggactgcag     1740

gcctccgacc tgcctgccag cgccagcctg ccagccaagg ctgacctcct gctcagcacc     1800

cagccaggcc gtgaggaggg ctcccctctt gagctggaac gcctgaaact ggagcctcac     1860

gaagggctgc tgctccgctt cccctacgcg gcctga                               1896


<210>  7
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val Arg Lys Pro Val Val Ser Thr Ile Ser Lys Gly Gly Tyr Leu 
1               5                   10                  15      


Gln Gly Asn Val Asn Gly Arg Leu Pro Ser Leu Gly Asn Lys Glu Pro 
            20                  25                  30          


Pro Gly Gln Glu Lys Val Gln Leu Lys Arg Lys Val Thr Leu Leu Arg 
        35                  40                  45              


Gly Val Ser Ile Ile Ile Gly Thr Ile Ile Gly Ala Gly Ile Phe Ile 
    50                  55                  60                  


Ser Pro Lys Gly Val Leu Gln Asn Thr Gly Ser Val Gly Met Ser Leu 
65                  70                  75                  80  


Thr Ile Trp Thr Val Cys Gly Val Leu Ser Leu Phe Gly Ala Leu Ser 
                85                  90                  95      


Tyr Ala Glu Leu Gly Thr Thr Ile Lys Lys Ser Gly Gly His Tyr Thr 
            100                 105                 110         


Tyr Ile Leu Glu Val Phe Gly Pro Leu Pro Ala Phe Val Arg Val Trp 
        115                 120                 125             


Val Glu Leu Leu Ile Ile Arg Pro Ala Ala Thr Ala Val Ile Ser Leu 
    130                 135                 140                 


Ala Phe Gly Arg Tyr Ile Leu Glu Pro Phe Phe Ile Gln Cys Glu Ile 
145                 150                 155                 160 


Pro Glu Leu Ala Ile Lys Leu Ile Thr Ala Val Gly Ile Thr Val Val 
                165                 170                 175     


Met Val Leu Asn Ser Met Ser Val Ser Trp Ser Ala Arg Ile Gln Ile 
            180                 185                 190         


Phe Leu Thr Phe Cys Lys Leu Thr Ala Ile Leu Ile Ile Ile Val Pro 
        195                 200                 205             


Gly Val Met Gln Leu Ile Lys Gly Gln Thr Gln Asn Phe Lys Asp Ala 
    210                 215                 220                 


Phe Ser Gly Arg Asp Ser Ser Ile Thr Arg Leu Pro Leu Ala Phe Tyr 
225                 230                 235                 240 


Tyr Gly Met Tyr Ala Tyr Ala Gly Trp Phe Tyr Leu Asn Phe Val Thr 
                245                 250                 255     


Glu Glu Val Glu Asn Pro Glu Lys Thr Ile Pro Leu Ala Ile Cys Ile 
            260                 265                 270         


Ser Met Ala Ile Val Thr Ile Gly Tyr Val Leu Thr Asn Val Ala Tyr 
        275                 280                 285             


Phe Thr Thr Ile Asn Ala Glu Glu Leu Leu Leu Ser Asn Ala Val Ala 
    290                 295                 300                 


Val Thr Phe Ser Glu Arg Leu Leu Gly Asn Phe Ser Leu Ala Val Pro 
305                 310                 315                 320 


Ile Phe Val Ala Leu Ser Cys Phe Gly Ser Met Asn Gly Gly Val Phe 
                325                 330                 335     


Ala Val Ser Arg Leu Phe Tyr Val Ala Ser Arg Glu Gly His Leu Pro 
            340                 345                 350         


Glu Ile Leu Ser Met Ile His Val Arg Lys His Thr Pro Leu Pro Ala 
        355                 360                 365             


Val Ile Val Leu His Pro Leu Thr Met Ile Met Leu Phe Ser Gly Asp 
    370                 375                 380                 


Leu Asp Ser Leu Leu Asn Phe Leu Ser Phe Ala Arg Trp Leu Phe Ile 
385                 390                 395                 400 


Gly Leu Ala Val Ala Gly Leu Ile Tyr Leu Arg Tyr Lys Cys Pro Asp 
                405                 410                 415     


Met His Arg Pro Phe Lys Val Pro Leu Phe Ile Pro Ala Leu Phe Ser 
            420                 425                 430         


Phe Thr Cys Leu Phe Met Val Ala Leu Ser Leu Tyr Ser Asp Pro Phe 
        435                 440                 445             


Ser Thr Gly Ile Gly Phe Val Ile Thr Leu Thr Gly Val Pro Ala Tyr 
    450                 455                 460                 


Tyr Leu Phe Ile Ile Trp Asp Lys Lys Pro Arg Trp Phe Arg Ile Met 
465                 470                 475                 480 


Ser Glu Lys Ile Thr Arg Thr Leu Gln Ile Ile Leu Glu Val Val Pro 
                485                 490                 495     


Glu Glu Asp Lys Leu 
            500     


<210>  8
<211>  1506
<212>  DNA
<213>  Homo sapiens

<400>  8
atggtcagaa agcctgttgt gtccaccatc tccaaaggag gttacctgca gggaaatgtt       60

aacgggaggc tgccttccct gggcaacaag gagccacctg ggcaggagaa agtgcagctg      120

aagaggaaag tcactttact gaggggagtc tccattatca ttggcaccat cattggagca      180

ggaatcttca tctctcctaa gggcgtgctc cagaacacgg gcagcgtggg catgtctctg      240

accatctgga cggtgtgtgg ggtcctgtca ctatttggag ctttgtctta tgctgaattg      300

ggaacaacta taaagaaatc tggaggtcat tacacatata ttttggaagt ctttggtcca      360

ttaccagctt ttgtacgagt ctgggtggaa ctcctcataa tacgccctgc agctactgct      420

gtgatatccc tggcatttgg acgctacatt ctggaaccat tttttattca atgtgaaatc      480

cctgaacttg cgatcaagct cattacagct gtgggcataa ctgtagtgat ggtcctaaat      540

agcatgagtg tcagctggag cgcccggatc cagattttct taaccttttg caagctcaca      600

gcaattctga taattatagt ccctggagtt atgcagctaa ttaaaggtca aacgcagaac      660

tttaaagacg ccttttcagg aagagattca agtattacgc ggttgccact ggctttttat      720

tatggaatgt atgcatatgc tggctggttt tacctcaact ttgttactga agaagtagaa      780

aaccctgaaa aaaccattcc ccttgcaata tgtatatcca tggccattgt caccattggc      840

tatgtgctga caaatgtggc ctactttacg accattaatg ctgaggagct gctgctttca      900

aatgcagtgg cagtgacctt ttctgagcgg ctactgggaa atttctcatt agcagttccg      960

atctttgttg ccctctcctg ctttggctcc atgaacggtg gtgtgtttgc tgtctccagg     1020

ttattctatg ttgcgtctcg agagggtcac cttccagaaa tcctctccat gattcatgtc     1080

cgcaagcaca ctcctctacc agctgttatt gttttgcacc ctttgacaat gataatgctc     1140

ttctctggag acctcgacag tcttttgaat ttcctcagtt ttgccaggtg gctttttatt     1200

gggctggcag ttgctgggct gatttatctt cgatacaaat gcccagatat gcatcgtcct     1260

ttcaaggtgc cactgttcat cccagctttg ttttccttca catgcctctt catggttgcc     1320

ctttccctct attcggaccc atttagtaca gggattggct tcgtcatcac tctgactgga     1380

gtccctgcgt attatctctt tattatatgg gacaagaaac ccaggtggtt tagaataatg     1440

tcggagaaaa taaccagaac attacaaata atactggaag ttgtaccaga agaagataag     1500

ttatga                                                                1506


<210>  9
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A CLEAVAGE SEQUENCE

<400>  9
gccaccaact tcagcctgct gaagcaggcc ggcgacgtgg aggaaaaccc tggcccc          57


<210>  10
<211>  1109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR targeting GD2

<400>  10

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Ile Leu Leu 
        355                 360                 365             


Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser 
    370                 375                 380                 


Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg Asn Gly Asn Thr 
385                 390                 395                 400 


Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                405                 410                 415     


Ile His Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
            420                 425                 430         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
        435                 440                 445             


Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro 
    450                 455                 460                 


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp 
465                 470                 475                 480 


Ala Ala Pro Thr Val Ser Ile Phe Pro Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Glu Val Lys Leu Gln Gln Ser Gly Pro Ser Leu Val Glu Pro 
            500                 505                 510         


Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr 
        515                 520                 525             


Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly Lys Ser Leu Glu 
    530                 535                 540                 


Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln 
545                 550                 555                 560 


Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
                565                 570                 575     


Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            580                 585                 590         


Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly Thr Ser Val Thr 
        595                 600                 605             


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Gly Arg Val Thr 
    610                 615                 620                 


Val Ser Ser Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
625                 630                 635                 640 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                645                 650                 655     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            660                 665                 670         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        675                 680                 685             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    690                 695                 700                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
705                 710                 715                 720 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                725                 730                 735     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            740                 745                 750         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        755                 760                 765             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    770                 775                 780                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
785                 790                 795                 800 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                805                 810                 815     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            820                 825                 830         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        835                 840                 845             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys 
    850                 855                 860                 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
865                 870                 875                 880 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
                885                 890                 895     


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
            900                 905                 910         


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
        915                 920                 925             


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    930                 935                 940                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
945                 950                 955                 960 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                965                 970                 975     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
            980                 985                 990         


Asn Gln Leu Tyr Asn Glu Leu Asn  Leu Gly Arg Arg Glu  Glu Tyr Asp 
        995                 1000                 1005             


Val Leu  Asp Lys Arg Arg Gly  Arg Asp Pro Glu Met  Gly Gly Lys 
    1010                 1015                 1020             


Pro Arg  Arg Lys Asn Pro Gln  Glu Gly Leu Tyr Asn  Glu Leu Gln 
    1025                 1030                 1035             


Lys Asp  Lys Met Ala Glu Ala  Tyr Ser Glu Ile Gly  Met Lys Gly 
    1040                 1045                 1050             


Glu Arg  Arg Arg Gly Lys Gly  His Asp Gly Leu Tyr  Gln Gly Leu 
    1055                 1060                 1065             


Ser Thr  Ala Thr Lys Asp Thr  Tyr Asp Ala Leu His  Met Gln Ala 
    1070                 1075                 1080             


Leu Pro  Pro Arg Gly Ser Gly  Ala Thr Asn Phe Ser  Leu Leu Lys 
    1085                 1090                 1095             


Gln Ala  Gly Asp Val Glu Glu  Asn Pro Gly Pro 
    1100                 1105                 


<210>  11
<211>  857
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR targeting CD33

<400>  11

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gly Ser Asn Ile 
        355                 360                 365             


Met Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly Glu Lys 
    370                 375                 380                 


Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe Phe Ser Ser Ser 
385                 390                 395                 400 


Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro Gly Gln Ser Pro 
                405                 410                 415     


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
            420                 425                 430         


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        435                 440                 445             


Ser Val Gln Ser Glu Asp Leu Ala Ile Tyr Tyr Cys His Gln Tyr Leu 
    450                 455                 460                 


Ser Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly 
465                 470                 475                 480 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Val 
                485                 490                 495     


Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val 
            500                 505                 510         


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile 
        515                 520                 525             


His Trp Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Val Gly Val 
    530                 535                 540                 


Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln Lys Phe Lys Gly 
545                 550                 555                 560 


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr Met Gln 
                565                 570                 575     


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
            580                 585                 590         


Glu Val Arg Leu Arg Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val 
        595                 600                 605             


Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    610                 615                 620                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
625                 630                 635                 640 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                645                 650                 655     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            660                 665                 670         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
        675                 680                 685             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    690                 695                 700                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
705                 710                 715                 720 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                725                 730                 735     


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            740                 745                 750         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        755                 760                 765             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    770                 775                 780                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
785                 790                 795                 800 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                805                 810                 815     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            820                 825                 830         


Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        835                 840                 845             


Gly Asp Val Glu Glu Asn Pro Gly Pro 
    850                 855         


<210>  12
<211>  850
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR targeting mesothelin

<400>  12

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Met Gln Val Gln 
        355                 360                 365             


Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Lys 
    370                 375                 380                 


Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn 
385                 390                 395                 400 


Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Leu Ile 
                405                 410                 415     


Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys 
            420                 425                 430         


Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Asp Leu 
        435                 440                 445             


Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly 
    450                 455                 460                 


Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
465                 470                 475                 480 


Thr Val Ser Ser Gly Val Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            500                 505                 510         


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
        515                 520                 525             


Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
    530                 535                 540                 


Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe 
545                 550                 555                 560 


Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val 
                565                 570                 575     


Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr 
            580                 585                 590         


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr 
        595                 600                 605             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    610                 615                 620                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
625                 630                 635                 640 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                645                 650                 655     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            660                 665                 670         


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        675                 680                 685             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    690                 695                 700                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
705                 710                 715                 720 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
                725                 730                 735     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            740                 745                 750         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        755                 760                 765             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    770                 775                 780                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
785                 790                 795                 800 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                805                 810                 815     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala 
            820                 825                 830         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        835                 840                 845             


Gly Pro 
    850 


<210>  13
<211>  864
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR targeting EGFR

<400>  13

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu 
        355                 360                 365             


Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser Leu Lys Leu 
    370                 375                 380                 


Ser Cys Val Thr Ser Gly Phe Thr Phe Arg Lys Phe Gly Met Ser Trp 
385                 390                 395                 400 


Val Arg Gln Thr Ser Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser 
                405                 410                 415     


Thr Gly Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe 
            420                 425                 430         


Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser 
        435                 440                 445             


Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Arg Gly Tyr 
    450                 455                 460                 


Ser Ser Thr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
465                 470                 475                 480 


Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ser Val 
            500                 505                 510         


Ala Thr Gly Glu Lys Val Thr Ile Arg Cys Met Thr Ser Thr Asp Ile 
        515                 520                 525             


Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys 
    530                 535                 540                 


Phe Leu Ile Ser Glu Gly Asn Thr Leu Arg Gly Val Pro Ser Arg Phe 
545                 550                 555                 560 


Ser Ser Ser Gly Thr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr 
                565                 570                 575     


Leu Ser Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln Ser Phe Asn Val 
            580                 585                 590         


Pro Leu Thr Phe Gly Asp Gly Thr Lys Leu Glu Lys Ala Leu Glu Gln 
        595                 600                 605             


Lys Leu Ile Ser Glu Glu Asp Leu Ala Lys Pro Thr Thr Thr Pro Ala 
    610                 615                 620                 


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
625                 630                 635                 640 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                645                 650                 655     


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            660                 665                 670         


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        675                 680                 685             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    690                 695                 700                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
705                 710                 715                 720 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                725                 730                 735     


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
            740                 745                 750         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        755                 760                 765             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    770                 775                 780                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
785                 790                 795                 800 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                805                 810                 815     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            820                 825                 830         


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn 
        835                 840                 845             


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
    850                 855                 860                 


<210>  14
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GD2 target binding moiety

<400>  14

Asp Ile Leu Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Glu Val Lys Leu Gln Gln Ser Gly Pro Ser 
    130                 135                 140                 


Leu Val Glu Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly 
145                 150                 155                 160 


Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly 
                165                 170                 175     


Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr 
            180                 185                 190         


Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp 
    210                 215                 220                 


Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr 
                245                 250                 255     


Gly Arg Val Thr Val Ser Ser 
            260             


<210>  15
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 target binding moiety

<400>  15

Gly Ser Asn Ile Met Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser 
1               5                   10                  15      


Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe 
            20                  25                  30          


Phe Ser Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro 
        35                  40                  45              


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser 
    50                  55                  60                  


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
65                  70                  75                  80  


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Leu Ala Ile Tyr Tyr Cys 
                85                  90                  95      


His Gln Tyr Leu Ser Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro 
    130                 135                 140                 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
145                 150                 155                 160 


Ser Tyr Tyr Ile His Trp Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu 
                165                 170                 175     


Trp Val Gly Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln 
            180                 185                 190         


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr 
        195                 200                 205             


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Glu Val Arg Leu Arg Tyr Phe Asp Val Trp Gly Ala 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser 
                245             


<210>  16
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mesothelin target binding moiety

<400>  16

Met Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly 
            20                  25                  30          


Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
        35                  40                  45              


Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Val Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr 
                165                 170                 175     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Gly Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  17
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFRVIII target binding moiety

<400>  17

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Arg Lys Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Ser Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Tyr Ser Ser Thr Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ser Leu Ser Val Ala Thr Gly Glu Lys Val Thr Ile Arg Cys Met Thr 
145                 150                 155                 160 


Ser Thr Asp Ile Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Glu Pro Pro Lys Phe Leu Ile Ser Glu Gly Asn Thr Leu Arg Pro Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Ser Ser Gly Thr Gly Thr Asp Phe Val Phe 
        195                 200                 205             


Thr Ile Glu Asn Thr Leu Ser Glu Asp Val Gly Asp Tyr 
    210                 215                 220     


<210>  18
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alternative EGFRvIII binding moiety

<400>  18

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Leu Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Arg Lys Phe Gly Met Ser Trp Val Arg Gln Thr Ser Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Ser Ile Ser Thr Gly Gly Tyr Asn Thr Tyr Tyr Ser 
65                  70                  75                  80  


Asp Asn Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Tyr Ser Ser Thr Ser Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Ser Leu Ser Val Ala Thr Gly Glu Lys Val Thr Ile Arg 
                165                 170                 175     


Cys Met Thr Ser Thr Asp Ile Asp Asp Asp Met Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Glu Pro Pro Lys Phe Leu Ile Ser Glu Gly Asn Thr Leu 
        195                 200                 205             


Arg Pro Gly Val Pro Ser Arg Phe Ser Ser Ser Gly Thr Gly Thr Asp 
    210                 215                 220                 


Phe Val Phe Thr Ile Glu Asn Thr Leu Ser Glu Asp Val Gly Asp Tyr 
225                 230                 235                 240 


Tyr Cys Leu Gln Ser Phe Asn Val Pro Leu Thr Phe Gly Asp Gly Thr 
                245                 250                 255     


Lys Leu Glu Lys Ala Leu 
            260         


<210>  19
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  alternative EGFRvIII target binding moiety (EGFRvIII scFv 
       sequence derived from MR1 antibody)

<400>  19
atggactgga tttggcgcat ccttttcctt gtcggcgctg ctaccggcgc gcattctcag       60

gtacaactcc agcagtctgg gggaggctta gtgaagcctg gagcgtctct gaaactctcc      120

tgtgtaacct ctggattcac tttcagaaaa tttggcatgt cttgggttcg ccagactagt      180

gacaagaggc tggaatgggt cgcatccatt agtactggcg gttataacac gtactattca      240

gacaatgtaa agggccgatt caccatctcc agagagaatg ccaagaacac cctgtacctg      300

caaatgagta gtctgaagtc tgaggacacg gccttgtatt actgtacaag aggctattct      360

agtacctctt atgctatgga ctactggggc caagggacca cggtcaccgt ctcctcaagt      420

ggaggcggtt caggcggagg tggctctggc ggtggcggat cggacatcga gctcactcag      480

tctccagcat ccctgtccgt ggctacagga gaaaaagtca ctatcagatg catgaccagc      540

actgatattg atgatgatat gaactggtac cagcagaagc caggggaacc ccctaagttc      600

cttatttcag aaggcaatac tcttcggccg ggagtcccat cccgattttc cagcagtggc      660

actggcacag attttgtttt tacaattgaa aacacactct cggaagatgt tggagattac      720

tactgtttgc aaagctttaa cgtgcctctt acattcggtg atggcaccaa gcttgaaaaa      780

gctcta                                                                 786


<210>  20
<211>  4086
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR (as fusion target-binding protein) and SLC7A5 (as 
       amino acid transporter)

<400>  20
atgcctcgcg gctggacagc cctgtgcctg ctgtctctgc tgccatccgg cttcatgagc       60

ctggataata acggcacagc caccccagag ctgcctacac agggcacctt cagcaatgtg      120

tccacaaacg tgagctatca ggagaccaca accccttcta ccctgggatc cacaagcctg      180

caccccgtgt ctcagcacgg caacgaagcc accaccaaca tcaccgagac cacagtgaag      240

tttacctcca cctctgtgat tacctctgtg tacggaaata caaactccag cgtgcagtct      300

cagacatctg tgatctccac agtgtttaca acacctgcca atgtgtccac cccagagaca      360

accctgaagc ccagcctgtc tcctggaaat gtgtccgatc tgtctaccac ctccaccagc      420

ctggccacct ctcccaccaa gccctatacc tcctcttctc ccatcctgag cgatatcaaa      480

gccgagatca aatgcagcgg gattcgggaa gtgaaactga cacagggcat ctgcctggaa      540

cagaataaga catccagctg cgccgagttt aagaaagata gaggagaggg actggccagg      600

gtgctgtgtg gcgaagagca ggccgacgcc gatgccggcg cccaggtgtg ttccctgctg      660

ctggcccagt ctgaggtgcg cccccagtgc ctgctgctgg tgctggccaa tcggacagaa      720

attagcagca agctgcagct gatgaaaaaa caccagagcg atctgaaaaa gctgggcatc      780

ctggacttta ccgagcagga cgtggcctct caccagagct acagccagaa aacactgatc      840

gccctggtga ccagcggagc cctgctggcc gtgctgggca tcaccggata tttcctgatg      900

aataggcgca gctggagccc caccggcgaa cggctggagc tggagcctgt cgaccgagtg      960

aagcagaccc tgaactttga tctgctgaag ctggccggcg acgtggagtc caaccccggg     1020

ccagggaata tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac     1080

gccgccaggc cgggatccaa catcatgctg acccagagcc ctagcagcct ggccgtgtct     1140

gccggcgaga aagtgaccat gagctgcaag agcagccaga gcgtgttctt cagcagctcc     1200

cagaagaact acctagcctg gtatcagcag atcccaggcc agagccctaa gctgctgatc     1260

tactgggcca gcaccagaga aagcggcgtg cccgatagat tcaccggaag cggttctggc     1320

accgacttca ccctgacaat cagcagcgtg cagagcgagg acctggccat ctactactgc     1380

caccagtacc tgagcagccg gacctttggc ggaggcacca agctggaaat caagagaggc     1440

ggcggaggct caggcggagg cggatctagt ggcggaggat ctcaggtgca gctgcagcag     1500

ccaggcgccg aggtcgtgaa acctggcgcc tctgtgaaga tgtcctgcaa ggccagcggc     1560

tacaccttca ccagctacta catccactgg atcaagcaga cccctggaca gggcctggaa     1620

tgggtgggag tgatctaccc cggcaacgac gacatcagct acaaccagaa gttcaagggc     1680

aaggccaccc tgaccgccga caagtctagc accaccgcct acatgcagct gtccagcctg     1740

accagcgagg acagcgccgt gtactactgc gccagagaag tgcggctgcg gtacttcgat     1800

gtgtggggag ccggcaccac cgtgaccgtg tcatctacca cgacgccagc accgcgacca     1860

ccaacaccgg cgccaaccat cgcatcgcag cccctgtccc tgcgcccaga ggcgtgccga     1920

ccagcggcgg ggggcgcagt gcacacgagg gggctggact tcgcctgtga tatctacatc     1980

tgggcgccct tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac     2040

tgcaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta     2100

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     2160

tgtgaactga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag     2220

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     2280

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     2340

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     2400

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     2460

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgcgccac caacttcagc     2520

ctgctgaagc aggccggcga cgtggaggaa aaccctggcc ccatggccgg cgctggacct     2580

aagagaaggg ctctggctgc tcccgctgct gaggagaaag aagaggctag agagaagatg     2640

ctggctgcta agagcgccga tggctccgct cccgccggag aaggagaggg cgtgacactg     2700

cagaggaaca tcacactgct caacggcgtc gccattatcg tgggcaccat cattggaagc     2760

ggcatcttcg tgacccccac cggcgtgctg aaggaggctg gatcccccgg actggctctg     2820

gtggtctggg ctgcttgcgg cgtgttcagc attgtgggcg ctctgtgtta cgccgaactg     2880

ggcaccacca ttagcaaaag cggaggagac tacgcctaca tgctggaagt gtacggaagc     2940

ctccccgcct tcctcaagct gtggatcgag ctgctgatca ttaggccttc cagccagtac     3000

atcgtcgccc tcgtcttcgc cacatatctg ctcaagcctc tgtttcccac atgccccgtg     3060

cccgaggagg ctgctaaact ggtcgcttgt ctctgtgtgc tgctgctgac agccgtcaat     3120

tgttacagcg tcaaggctgc cacaagagtg caagacgctt ttgccgccgc taagctgctc     3180

gccctcgctc tgatcattct gctgggcttc gtccaaattg gcaagggcga tgtcagcaat     3240

ctggacccca acttctcctt cgagggcacc aaactcgacg tgggcaacat cgtgctcgct     3300

ctgtattccg gactgttcgc ttacggaggc tggaactatc tgaacttcgt caccgaggag     3360

atgatcaacc cctatagaaa tctgcctctg gctatcatca tctctctgcc catcgtcaca     3420

ctggtgtatg tgctcaccaa tctggcctac ttcaccacac tgagcacaga acagatgctg     3480

tccagcgaag ccgtcgccgt ggactttggc aactatcatc tgggcgtgat gagctggatc     3540

atccccgtgt tcgtcggact gagctgcttc ggctccgtga atggatccct ctttacaagc     3600

tctagactct tcttcgtggg ctctagagag ggacatctgc ctagcatcct cagcatgatt     3660

caccctcagc tgctgacccc cgtgccctct ctggtgttca catgcgtgat gacactgctg     3720

tacgccttca gcaaggatat cttcagcgtg attaattttt ttagcttttt caactggctc     3780

tgcgtggctc tggccatcat tggcatgatt tggctgagac atagaaaacc cgagctggag     3840

aggcccatca aagtgaatct ggctctgccc gtgttcttca ttctcgcttg tctgtttctg     3900

attgccgtgt ccttctggaa gacccccgtg gaatgcggca ttggcttcac catcattctg     3960

tccggcctcc ccgtgtactt cttcggcgtc tggtggaaga acaagcccaa gtggctgctg     4020

caaggcatct tcagcaccac agtgctgtgc caaaagctga tgcaagtggt gccccaagag     4080

acatga                                                                4086


<210>  21
<211>  1361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence produced on expression of the nucleic acids 
       construct of Sequence ID No: 20

<400>  21

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gly Ser Asn Ile 
        355                 360                 365             


Met Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly Glu Lys 
    370                 375                 380                 


Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe Phe Ser Ser Ser 
385                 390                 395                 400 


Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro Gly Gln Ser Pro 
                405                 410                 415     


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
            420                 425                 430         


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        435                 440                 445             


Ser Val Gln Ser Glu Asp Leu Ala Ile Tyr Tyr Cys His Gln Tyr Leu 
    450                 455                 460                 


Ser Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly 
465                 470                 475                 480 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Val 
                485                 490                 495     


Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val 
            500                 505                 510         


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile 
        515                 520                 525             


His Trp Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Val Gly Val 
    530                 535                 540                 


Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln Lys Phe Lys Gly 
545                 550                 555                 560 


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr Met Gln 
                565                 570                 575     


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
            580                 585                 590         


Glu Val Arg Leu Arg Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val 
        595                 600                 605             


Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    610                 615                 620                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
625                 630                 635                 640 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                645                 650                 655     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            660                 665                 670         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
        675                 680                 685             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    690                 695                 700                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
705                 710                 715                 720 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                725                 730                 735     


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            740                 745                 750         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        755                 760                 765             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    770                 775                 780                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
785                 790                 795                 800 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                805                 810                 815     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            820                 825                 830         


Pro Pro Arg Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
        835                 840                 845             


Glu Glu Asn Pro Gly Pro Met Ala Gly Ala Gly Pro Lys Arg Arg Ala 
    850                 855                 860                 


Leu Ala Ala Pro Ala Ala Glu Glu Lys Glu Glu Ala Arg Glu Lys Met 
865                 870                 875                 880 


Leu Ala Ala Lys Ser Ala Asp Gly Ser Ala Pro Ala Gly Glu Gly Glu 
                885                 890                 895     


Gly Val Thr Leu Gln Arg Asn Ile Thr Leu Leu Asn Gly Val Ala Ile 
            900                 905                 910         


Ile Val Gly Thr Ile Ile Gly Ser Gly Ile Phe Val Thr Pro Thr Gly 
        915                 920                 925             


Val Leu Lys Glu Ala Gly Ser Pro Gly Leu Ala Leu Val Val Trp Ala 
    930                 935                 940                 


Ala Cys Gly Val Phe Ser Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu 
945                 950                 955                 960 


Gly Thr Thr Ile Ser Lys Ser Gly Gly Asp Tyr Ala Tyr Met Leu Glu 
                965                 970                 975     


Val Tyr Gly Ser Leu Pro Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu 
            980                 985                 990         


Ile Ile Arg Pro Ser Ser Gln Tyr  Ile Val Ala Leu Val  Phe Ala Thr 
        995                 1000                 1005             


Tyr Leu  Leu Lys Pro Leu Phe  Pro Thr Cys Pro Val  Pro Glu Glu 
    1010                 1015                 1020             


Ala Ala  Lys Leu Val Ala Cys  Leu Cys Val Leu Leu  Leu Thr Ala 
    1025                 1030                 1035             


Val Asn  Cys Tyr Ser Val Lys  Ala Ala Thr Arg Val  Gln Asp Ala 
    1040                 1045                 1050             


Phe Ala  Ala Ala Lys Leu Leu  Ala Leu Ala Leu Ile  Ile Leu Leu 
    1055                 1060                 1065             


Gly Phe  Val Gln Ile Gly Lys  Gly Asp Val Ser Asn  Leu Asp Pro 
    1070                 1075                 1080             


Asn Phe  Ser Phe Glu Gly Thr  Lys Leu Asp Val Gly  Asn Ile Val 
    1085                 1090                 1095             


Leu Ala  Leu Tyr Ser Gly Leu  Phe Ala Tyr Gly Gly  Trp Asn Tyr 
    1100                 1105                 1110             


Leu Asn  Phe Val Thr Glu Glu  Met Ile Asn Pro Tyr  Arg Asn Leu 
    1115                 1120                 1125             


Pro Leu  Ala Ile Ile Ile Ser  Leu Pro Ile Val Thr  Leu Val Tyr 
    1130                 1135                 1140             


Val Leu  Thr Asn Leu Ala Tyr  Phe Thr Thr Leu Ser  Thr Glu Gln 
    1145                 1150                 1155             


Met Leu  Ser Ser Glu Ala Val  Ala Val Asp Phe Gly  Asn Tyr His 
    1160                 1165                 1170             


Leu Gly  Val Met Ser Trp Ile  Ile Pro Val Phe Val  Gly Leu Ser 
    1175                 1180                 1185             


Cys Phe  Gly Ser Val Asn Gly  Ser Leu Phe Thr Ser  Ser Arg Leu 
    1190                 1195                 1200             


Phe Phe  Val Gly Ser Arg Glu  Gly His Leu Pro Ser  Ile Leu Ser 
    1205                 1210                 1215             


Met Ile  His Pro Gln Leu Leu  Thr Pro Val Pro Ser  Leu Val Phe 
    1220                 1225                 1230             


Thr Cys  Val Met Thr Leu Leu  Tyr Ala Phe Ser Lys  Asp Ile Phe 
    1235                 1240                 1245             


Ser Val  Ile Asn Phe Phe Ser  Phe Phe Asn Trp Leu  Cys Val Ala 
    1250                 1255                 1260             


Leu Ala  Ile Ile Gly Met Ile  Trp Leu Arg His Arg  Lys Pro Glu 
    1265                 1270                 1275             


Leu Glu  Arg Pro Ile Lys Val  Asn Leu Ala Leu Pro  Val Phe Phe 
    1280                 1285                 1290             


Ile Leu  Ala Cys Leu Phe Leu  Ile Ala Val Ser Phe  Trp Lys Thr 
    1295                 1300                 1305             


Pro Val  Glu Cys Gly Ile Gly  Phe Thr Ile Ile Leu  Ser Gly Leu 
    1310                 1315                 1320             


Pro Val  Tyr Phe Phe Gly Val  Trp Trp Lys Asn Lys  Pro Lys Trp 
    1325                 1330                 1335             


Leu Leu  Gln Gly Ile Phe Ser  Thr Thr Val Leu Cys  Gln Lys Leu 
    1340                 1345                 1350             


Met Gln  Val Val Pro Gln Glu  Thr 
    1355                 1360     


<210>  22
<211>  4068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR (as fusion target-binding protein) and SLC7A11 (as 
       amino acid transporter)

<400>  22
atgcctcgcg gctggacagc cctgtgcctg ctgtctctgc tgccatccgg cttcatgagc       60

ctggataata acggcacagc caccccagag ctgcctacac agggcacctt cagcaatgtg      120

tccacaaacg tgagctatca ggagaccaca accccttcta ccctgggatc cacaagcctg      180

caccccgtgt ctcagcacgg caacgaagcc accaccaaca tcaccgagac cacagtgaag      240

tttacctcca cctctgtgat tacctctgtg tacggaaata caaactccag cgtgcagtct      300

cagacatctg tgatctccac agtgtttaca acacctgcca atgtgtccac cccagagaca      360

accctgaagc ccagcctgtc tcctggaaat gtgtccgatc tgtctaccac ctccaccagc      420

ctggccacct ctcccaccaa gccctatacc tcctcttctc ccatcctgag cgatatcaaa      480

gccgagatca aatgcagcgg gattcgggaa gtgaaactga cacagggcat ctgcctggaa      540

cagaataaga catccagctg cgccgagttt aagaaagata gaggagaggg actggccagg      600

gtgctgtgtg gcgaagagca ggccgacgcc gatgccggcg cccaggtgtg ttccctgctg      660

ctggcccagt ctgaggtgcg cccccagtgc ctgctgctgg tgctggccaa tcggacagaa      720

attagcagca agctgcagct gatgaaaaaa caccagagcg atctgaaaaa gctgggcatc      780

ctggacttta ccgagcagga cgtggcctct caccagagct acagccagaa aacactgatc      840

gccctggtga ccagcggagc cctgctggcc gtgctgggca tcaccggata tttcctgatg      900

aataggcgca gctggagccc caccggcgaa cggctggagc tggagcctgt cgaccgagtg      960

aagcagaccc tgaactttga tctgctgaag ctggccggcg acgtggagtc caaccccggg     1020

ccagggaata tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac     1080

gccgccaggc cgggatccaa catcatgctg acccagagcc ctagcagcct ggccgtgtct     1140

gccggcgaga aagtgaccat gagctgcaag agcagccaga gcgtgttctt cagcagctcc     1200

cagaagaact acctagcctg gtatcagcag atcccaggcc agagccctaa gctgctgatc     1260

tactgggcca gcaccagaga aagcggcgtg cccgatagat tcaccggaag cggttctggc     1320

accgacttca ccctgacaat cagcagcgtg cagagcgagg acctggccat ctactactgc     1380

caccagtacc tgagcagccg gacctttggc ggaggcacca agctggaaat caagagaggc     1440

ggcggaggct caggcggagg cggatctagt ggcggaggat ctcaggtgca gctgcagcag     1500

ccaggcgccg aggtcgtgaa acctggcgcc tctgtgaaga tgtcctgcaa ggccagcggc     1560

tacaccttca ccagctacta catccactgg atcaagcaga cccctggaca gggcctggaa     1620

tgggtgggag tgatctaccc cggcaacgac gacatcagct acaaccagaa gttcaagggc     1680

aaggccaccc tgaccgccga caagtctagc accaccgcct acatgcagct gtccagcctg     1740

accagcgagg acagcgccgt gtactactgc gccagagaag tgcggctgcg gtacttcgat     1800

gtgtggggag ccggcaccac cgtgaccgtg tcatctacca cgacgccagc accgcgacca     1860

ccaacaccgg cgccaaccat cgcatcgcag cccctgtccc tgcgcccaga ggcgtgccga     1920

ccagcggcgg ggggcgcagt gcacacgagg gggctggact tcgcctgtga tatctacatc     1980

tgggcgccct tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac     2040

tgcaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta     2100

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     2160

tgtgaactga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag     2220

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     2280

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     2340

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     2400

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     2460

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgcgccac caacttcagc     2520

ctgctgaagc aggccggcga cgtggaggaa aaccctggcc ccatggtgag gaaacccgtg     2580

gtgtccacaa tcagcaaggg cggctatctg caaggcaatg tgaacggcag actgcctagc     2640

ctcggaaaca aggaaccccc cggccaagag aaggtgcagc tgaagaggaa agtgacactg     2700

ctgagaggcg tctccatcat tatcggcacc atcatcggag ctggcatctt catcagccct     2760

aagggcgtgc tccagaacac cggatccgtc ggcatgtctc tgaccatctg gaccgtctgc     2820

ggcgtgctgt ctctgtttgg cgccctctcc tacgccgagc tgggaacaac catcaagaag     2880

tccggcggcc actataccta cattctggaa gtcttcggcc ctctgcccgc ctttgtgaga     2940

gtgtgggtgg agctgctgat cattagaccc gccgccaccg ctgtcatttc tctggctttc     3000

ggaaggtaca ttctggagcc cttcttcatc cagtgtgaga tccccgagct ggctatcaag     3060

ctgatcaccg ctgtcggcat caccgtggtc atggtcctca acagcatgag cgtgagctgg     3120

agcgctagga tccagatctt tctgaccttc tgcaagctga cagccattct gatcatcatt     3180

gtccccggag tcatgcagct gattaagggc cagacccaga actttaagga cgcctttagc     3240

ggaagagaca gcagcatcac aaggctgccc ctcgcctttt actacggcat gtacgcctat     3300

gccggctggt tttatctgaa cttcgtcacc gaggaggtgg agaaccccga gaagaccatc     3360

cctctggcca tctgcatctc catggccatc gtgacaatcg gatacgtgct caccaacgtc     3420

gcctacttta ccaccatcaa tgccgaagag ctgctgctct ccaatgctgt cgccgtcaca     3480

ttttccgaaa ggctgctggg caatttctct ctggccgtgc ctatctttgt ggctctgagc     3540

tgtttcggca gcatgaacgg cggagtgttc gccgtgtcta gactgttcta cgtggcctcc     3600

agagagggac atctgcccga gatcctctcc atgatccacg tgaggaagca cacccctctg     3660

cccgccgtga tcgtgctcca ccctctgacc atgatcatgc tcttttccgg agatctggat     3720

tctctgctga actttctgtc cttcgctaga tggctgttta tcggactggc tgtggccgga     3780

ctgatttatc tgagatacaa gtgccccgac atgcacagac cctttaaggt gcctctgttt     3840

atccccgctc tgttcagctt cacatgtctg ttcatggtcg ccctctccct ctacagcgac     3900

cccttctcca ccggcatcgg attcgtcatt acactgaccg gcgtgcccgc ctattacctc     3960

tttatcatct gggacaagaa gcctagatgg tttaggatca tgagcgagaa gatcacaaga     4020

accctccaaa tcattctcga ggtggtcccc gaggaagata agctgtga                  4068


<210>  23
<211>  1355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence produced on expression of the nucleic acids 
       construct of Sequence ID No: 21

<400>  23

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gly Ser Asn Ile 
        355                 360                 365             


Met Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly Glu Lys 
    370                 375                 380                 


Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe Phe Ser Ser Ser 
385                 390                 395                 400 


Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro Gly Gln Ser Pro 
                405                 410                 415     


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
            420                 425                 430         


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        435                 440                 445             


Ser Val Gln Ser Glu Asp Leu Ala Ile Tyr Tyr Cys His Gln Tyr Leu 
    450                 455                 460                 


Ser Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly 
465                 470                 475                 480 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Val 
                485                 490                 495     


Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val 
            500                 505                 510         


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile 
        515                 520                 525             


His Trp Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Val Gly Val 
    530                 535                 540                 


Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln Lys Phe Lys Gly 
545                 550                 555                 560 


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr Met Gln 
                565                 570                 575     


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
            580                 585                 590         


Glu Val Arg Leu Arg Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val 
        595                 600                 605             


Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    610                 615                 620                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
625                 630                 635                 640 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                645                 650                 655     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            660                 665                 670         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
        675                 680                 685             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    690                 695                 700                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
705                 710                 715                 720 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                725                 730                 735     


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            740                 745                 750         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        755                 760                 765             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    770                 775                 780                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
785                 790                 795                 800 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                805                 810                 815     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            820                 825                 830         


Pro Pro Arg Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
        835                 840                 845             


Glu Glu Asn Pro Gly Pro Met Val Arg Lys Pro Val Val Ser Thr Ile 
    850                 855                 860                 


Ser Lys Gly Gly Tyr Leu Gln Gly Asn Val Asn Gly Arg Leu Pro Ser 
865                 870                 875                 880 


Leu Gly Asn Lys Glu Pro Pro Gly Gln Glu Lys Val Gln Leu Lys Arg 
                885                 890                 895     


Lys Val Thr Leu Leu Arg Gly Val Ser Ile Ile Ile Gly Thr Ile Ile 
            900                 905                 910         


Gly Ala Gly Ile Phe Ile Ser Pro Lys Gly Val Leu Gln Asn Thr Gly 
        915                 920                 925             


Ser Val Gly Met Ser Leu Thr Ile Trp Thr Val Cys Gly Val Leu Ser 
    930                 935                 940                 


Leu Phe Gly Ala Leu Ser Tyr Ala Glu Leu Gly Thr Thr Ile Lys Lys 
945                 950                 955                 960 


Ser Gly Gly His Tyr Thr Tyr Ile Leu Glu Val Phe Gly Pro Leu Pro 
                965                 970                 975     


Ala Phe Val Arg Val Trp Val Glu Leu Leu Ile Ile Arg Pro Ala Ala 
            980                 985                 990         


Thr Ala Val Ile Ser Leu Ala Phe  Gly Arg Tyr Ile Leu  Glu Pro Phe 
        995                 1000                 1005             


Phe Ile  Gln Cys Glu Ile Pro  Glu Leu Ala Ile Lys  Leu Ile Thr 
    1010                 1015                 1020             


Ala Val  Gly Ile Thr Val Val  Met Val Leu Asn Ser  Met Ser Val 
    1025                 1030                 1035             


Ser Trp  Ser Ala Arg Ile Gln  Ile Phe Leu Thr Phe  Cys Lys Leu 
    1040                 1045                 1050             


Thr Ala  Ile Leu Ile Ile Ile  Val Pro Gly Val Met  Gln Leu Ile 
    1055                 1060                 1065             


Lys Gly  Gln Thr Gln Asn Phe  Lys Asp Ala Phe Ser  Gly Arg Asp 
    1070                 1075                 1080             


Ser Ser  Ile Thr Arg Leu Pro  Leu Ala Phe Tyr Tyr  Gly Met Tyr 
    1085                 1090                 1095             


Ala Tyr  Ala Gly Trp Phe Tyr  Leu Asn Phe Val Thr  Glu Glu Val 
    1100                 1105                 1110             


Glu Asn  Pro Glu Lys Thr Ile  Pro Leu Ala Ile Cys  Ile Ser Met 
    1115                 1120                 1125             


Ala Ile  Val Thr Ile Gly Tyr  Val Leu Thr Asn Val  Ala Tyr Phe 
    1130                 1135                 1140             


Thr Thr  Ile Asn Ala Glu Glu  Leu Leu Leu Ser Asn  Ala Val Ala 
    1145                 1150                 1155             


Val Thr  Phe Ser Glu Arg Leu  Leu Gly Asn Phe Ser  Leu Ala Val 
    1160                 1165                 1170             


Pro Ile  Phe Val Ala Leu Ser  Cys Phe Gly Ser Met  Asn Gly Gly 
    1175                 1180                 1185             


Val Phe  Ala Val Ser Arg Leu  Phe Tyr Val Ala Ser  Arg Glu Gly 
    1190                 1195                 1200             


His Leu  Pro Glu Ile Leu Ser  Met Ile His Val Arg  Lys His Thr 
    1205                 1210                 1215             


Pro Leu  Pro Ala Val Ile Val  Leu His Pro Leu Thr  Met Ile Met 
    1220                 1225                 1230             


Leu Phe  Ser Gly Asp Leu Asp  Ser Leu Leu Asn Phe  Leu Ser Phe 
    1235                 1240                 1245             


Ala Arg  Trp Leu Phe Ile Gly  Leu Ala Val Ala Gly  Leu Ile Tyr 
    1250                 1255                 1260             


Leu Arg  Tyr Lys Cys Pro Asp  Met His Arg Pro Phe  Lys Val Pro 
    1265                 1270                 1275             


Leu Phe  Ile Pro Ala Leu Phe  Ser Phe Thr Cys Leu  Phe Met Val 
    1280                 1285                 1290             


Ala Leu  Ser Leu Tyr Ser Asp  Pro Phe Ser Thr Gly  Ile Gly Phe 
    1295                 1300                 1305             


Val Ile  Thr Leu Thr Gly Val  Pro Ala Tyr Tyr Leu  Phe Ile Ile 
    1310                 1315                 1320             


Trp Asp  Lys Lys Pro Arg Trp  Phe Arg Ile Met Ser  Glu Lys Ile 
    1325                 1330                 1335             


Thr Arg  Thr Leu Gln Ile Ile  Leu Glu Val Val Pro  Glu Glu Asp 
    1340                 1345                 1350             


Lys Leu  
    1355 


