SEQUENCE LISTING

<110> Cellectis SA

<120> USE OF AMINOQUINOLINE COMPOUNDS FOR HIGHER GENE INTEGRATION

<130> P243009PC00

<150> US63119302
<151> 2020-11-30

<150> PA202170087
<151> 2021-02-25

<160> 49

<170> PatentIn version 3.5

<210>  1

<211>  653
<212>  PRT
<213>  homo sapiens

<220>
<223>  IDUA polypeptide sequence

<400>  1
Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser 
1               5                   10                  15      


Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val 
            20                  25                  30          


His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg 
        35                  40                  45              


Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr 
    50                  55                  60                  


Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val 
65                  70                  75                  80  


Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu 
                85                  90                  95      


Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr 
            100                 105                 110         


His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro 
        115                 120                 125             


Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu 
    130                 135                 140                 


Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala 
145                 150                 155                 160 


Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn 
                165                 170                 175     


Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser 
            180                 185                 190         


Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly 
        195                 200                 205             


Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser 
    210                 215                 220                 


Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His 
225                 230                 235                 240 


Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu 
                245                 250                 255     


Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile 
            260                 265                 270         


Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro 
        275                 280                 285             


Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val 
    290                 295                 300                 


Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala 
305                 310                 315                 320 


Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn 
                325                 330                 335     


Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe 
            340                 345                 350         


Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg 
        355                 360                 365             


Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys 
    370                 375                 380                 


Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln 
385                 390                 395                 400 


Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His 
                405                 410                 415     


Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp 
            420                 425                 430         


Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala 
        435                 440                 445             


His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro 
    450                 455                 460                 


Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu 
465                 470                 475                 480 


Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro 
                485                 490                 495     


Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala 
            500                 505                 510         


Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro 
        515                 520                 525             


Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro 
    530                 535                 540                 


Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr 
545                 550                 555                 560 


Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys 
                565                 570                 575     


Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr 
            580                 585                 590         


Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser 
        595                 600                 605             


Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp 
    610                 615                 620                 


Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu 
625                 630                 635                 640 


Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro 
                645                 650             


<210>  2

<211>  653
<212>  PRT
<213>  homo sapiens

<220>
<223>  IDS polypeptide sequence

<400>  2
Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser 
1               5                   10                  15      


Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val 
            20                  25                  30          


His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg 
        35                  40                  45              


Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr 
    50                  55                  60                  


Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val 
65                  70                  75                  80  


Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu 
                85                  90                  95      


Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr 
            100                 105                 110         


His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro 
        115                 120                 125             


Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu 
    130                 135                 140                 


Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala 
145                 150                 155                 160 


Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn 
                165                 170                 175     


Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser 
            180                 185                 190         


Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly 
        195                 200                 205             


Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser 
    210                 215                 220                 


Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His 
225                 230                 235                 240 


Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu 
                245                 250                 255     


Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile 
            260                 265                 270         


Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro 
        275                 280                 285             


Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val 
    290                 295                 300                 


Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala 
305                 310                 315                 320 


Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn 
                325                 330                 335     


Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe 
            340                 345                 350         


Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg 
        355                 360                 365             


Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys 
    370                 375                 380                 


Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln 
385                 390                 395                 400 


Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His 
                405                 410                 415     


Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp 
            420                 425                 430         


Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala 
        435                 440                 445             


His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro 
    450                 455                 460                 


Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu 
465                 470                 475                 480 


Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro 
                485                 490                 495     


Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala 
            500                 505                 510         


Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro 
        515                 520                 525             


Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro 
    530                 535                 540                 


Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr 
545                 550                 555                 560 


Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys 
                565                 570                 575     


Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr 
            580                 585                 590         


Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser 
        595                 600                 605             


Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp 
    610                 615                 620                 


Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu 
625                 630                 635                 640 


Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro 
                645                 650             


<210>  3

<211>  533
<212>  PRT
<213>  homo sapiens

<220>
<223>  ARSB polypeptide sequence

<400>  3
Met Gly Pro Arg Gly Ala Ala Ser Leu Pro Arg Gly Pro Gly Pro Arg 
1               5                   10                  15      


Arg Leu Leu Leu Pro Val Val Leu Pro Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Ala Pro Pro Gly Ser Gly Ala Gly Ala Ser Arg Pro Pro His Leu Val 
        35                  40                  45              


Phe Leu Leu Ala Asp Asp Leu Gly Trp Asn Asp Val Gly Phe His Gly 
    50                  55                  60                  


Ser Arg Ile Arg Thr Pro His Leu Asp Ala Leu Ala Ala Gly Gly Val 
65                  70                  75                  80  


Leu Leu Asp Asn Tyr Tyr Thr Gln Pro Leu Cys Thr Pro Ser Arg Ser 
                85                  90                  95      


Gln Leu Leu Thr Gly Arg Tyr Gln Ile Arg Thr Gly Leu Gln His Gln 
            100                 105                 110         


Ile Ile Trp Pro Cys Gln Pro Ser Cys Val Pro Leu Asp Glu Lys Leu 
        115                 120                 125             


Leu Pro Gln Leu Leu Lys Glu Ala Gly Tyr Thr Thr His Met Val Gly 
    130                 135                 140                 


Lys Trp His Leu Gly Met Tyr Arg Lys Glu Cys Leu Pro Thr Arg Arg 
145                 150                 155                 160 


Gly Phe Asp Thr Tyr Phe Gly Tyr Leu Leu Gly Ser Glu Asp Tyr Tyr 
                165                 170                 175     


Ser His Glu Arg Cys Thr Leu Ile Asp Ala Leu Asn Val Thr Arg Cys 
            180                 185                 190         


Ala Leu Asp Phe Arg Asp Gly Glu Glu Val Ala Thr Gly Tyr Lys Asn 
        195                 200                 205             


Met Tyr Ser Thr Asn Ile Phe Thr Lys Arg Ala Ile Ala Leu Ile Thr 
    210                 215                 220                 


Asn His Pro Pro Glu Lys Pro Leu Phe Leu Tyr Leu Ala Leu Gln Ser 
225                 230                 235                 240 


Val His Glu Pro Leu Gln Val Pro Glu Glu Tyr Leu Lys Pro Tyr Asp 
                245                 250                 255     


Phe Ile Gln Asp Lys Asn Arg His His Tyr Ala Gly Met Val Ser Leu 
            260                 265                 270         


Met Asp Glu Ala Val Gly Asn Val Thr Ala Ala Leu Lys Ser Ser Gly 
        275                 280                 285             


Leu Trp Asn Asn Thr Val Phe Ile Phe Ser Thr Asp Asn Gly Gly Gln 
    290                 295                 300                 


Thr Leu Ala Gly Gly Asn Asn Trp Pro Leu Arg Gly Arg Lys Trp Ser 
305                 310                 315                 320 


Leu Trp Glu Gly Gly Val Arg Gly Val Gly Phe Val Ala Ser Pro Leu 
                325                 330                 335     


Leu Lys Gln Lys Gly Val Lys Asn Arg Glu Leu Ile His Ile Ser Asp 
            340                 345                 350         


Trp Leu Pro Thr Leu Val Lys Leu Ala Arg Gly His Thr Asn Gly Thr 
        355                 360                 365             


Lys Pro Leu Asp Gly Phe Asp Val Trp Lys Thr Ile Ser Glu Gly Ser 
    370                 375                 380                 


Pro Ser Pro Arg Ile Glu Leu Leu His Asn Ile Asp Pro Asn Phe Val 
385                 390                 395                 400 


Asp Ser Ser Pro Cys Pro Arg Asn Ser Met Ala Pro Ala Lys Asp Asp 
                405                 410                 415     


Ser Ser Leu Pro Glu Tyr Ser Ala Phe Asn Thr Ser Val His Ala Ala 
            420                 425                 430         


Ile Arg His Gly Asn Trp Lys Leu Leu Thr Gly Tyr Pro Gly Cys Gly 
        435                 440                 445             


Tyr Trp Phe Pro Pro Pro Ser Gln Tyr Asn Val Ser Glu Ile Pro Ser 
    450                 455                 460                 


Ser Asp Pro Pro Thr Lys Thr Leu Trp Leu Phe Asp Ile Asp Arg Asp 
465                 470                 475                 480 


Pro Glu Glu Arg His Asp Leu Ser Arg Glu Tyr Pro His Ile Val Thr 
                485                 490                 495     


Lys Leu Leu Ser Arg Leu Gln Phe Tyr His Lys His Ser Val Pro Val 
            500                 505                 510         


Tyr Phe Pro Ala Gln Asp Pro Arg Cys Asp Pro Lys Ala Thr Gly Val 
        515                 520                 525             


Trp Gly Pro Trp Met 
    530             


<210>  4

<211>  651
<212>  PRT
<213>  homo sapiens

<220>
<223>  GUSB polypeptide sequence

<400>  4
Met Ala Arg Gly Ser Ala Val Ala Trp Ala Ala Leu Gly Pro Leu Leu 
1               5                   10                  15      


Trp Gly Cys Ala Leu Gly Leu Gln Gly Gly Met Leu Tyr Pro Gln Glu 
            20                  25                  30          


Ser Pro Ser Arg Glu Cys Lys Glu Leu Asp Gly Leu Trp Ser Phe Arg 
        35                  40                  45              


Ala Asp Phe Ser Asp Asn Arg Arg Arg Gly Phe Glu Glu Gln Trp Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Trp Glu Ser Gly Pro Thr Val Asp Met Pro Val Pro 
65                  70                  75                  80  


Ser Ser Phe Asn Asp Ile Ser Gln Asp Trp Arg Leu Arg His Phe Val 
                85                  90                  95      


Gly Trp Val Trp Tyr Glu Arg Glu Val Ile Leu Pro Glu Arg Trp Thr 
            100                 105                 110         


Gln Asp Leu Arg Thr Arg Val Val Leu Arg Ile Gly Ser Ala His Ser 
        115                 120                 125             


Tyr Ala Ile Val Trp Val Asn Gly Val Asp Thr Leu Glu His Glu Gly 
    130                 135                 140                 


Gly Tyr Leu Pro Phe Glu Ala Asp Ile Ser Asn Leu Val Gln Val Gly 
145                 150                 155                 160 


Pro Leu Pro Ser Arg Leu Arg Ile Thr Ile Ala Ile Asn Asn Thr Leu 
                165                 170                 175     


Thr Pro Thr Thr Leu Pro Pro Gly Thr Ile Gln Tyr Leu Thr Asp Thr 
            180                 185                 190         


Ser Lys Tyr Pro Lys Gly Tyr Phe Val Gln Asn Thr Tyr Phe Asp Phe 
        195                 200                 205             


Phe Asn Tyr Ala Gly Leu Gln Arg Ser Val Leu Leu Tyr Thr Thr Pro 
    210                 215                 220                 


Thr Thr Tyr Ile Asp Asp Ile Thr Val Thr Thr Ser Val Glu Gln Asp 
225                 230                 235                 240 


Ser Gly Leu Val Asn Tyr Gln Ile Ser Val Lys Gly Ser Asn Leu Phe 
                245                 250                 255     


Lys Leu Glu Val Arg Leu Leu Asp Ala Glu Asn Lys Val Val Ala Asn 
            260                 265                 270         


Gly Thr Gly Thr Gln Gly Gln Leu Lys Val Pro Gly Val Ser Leu Trp 
        275                 280                 285             


Trp Pro Tyr Leu Met His Glu Arg Pro Ala Tyr Leu Tyr Ser Leu Glu 
    290                 295                 300                 


Val Gln Leu Thr Ala Gln Thr Ser Leu Gly Pro Val Ser Asp Phe Tyr 
305                 310                 315                 320 


Thr Leu Pro Val Gly Ile Arg Thr Val Ala Val Thr Lys Ser Gln Phe 
                325                 330                 335     


Leu Ile Asn Gly Lys Pro Phe Tyr Phe His Gly Val Asn Lys His Glu 
            340                 345                 350         


Asp Ala Asp Ile Arg Gly Lys Gly Phe Asp Trp Pro Leu Leu Val Lys 
        355                 360                 365             


Asp Phe Asn Leu Leu Arg Trp Leu Gly Ala Asn Ala Phe Arg Thr Ser 
    370                 375                 380                 


His Tyr Pro Tyr Ala Glu Glu Val Met Gln Met Cys Asp Arg Tyr Gly 
385                 390                 395                 400 


Ile Val Val Ile Asp Glu Cys Pro Gly Val Gly Leu Ala Leu Pro Gln 
                405                 410                 415     


Phe Phe Asn Asn Val Ser Leu His His His Met Gln Val Met Glu Glu 
            420                 425                 430         


Val Val Arg Arg Asp Lys Asn His Pro Ala Val Val Met Trp Ser Val 
        435                 440                 445             


Ala Asn Glu Pro Ala Ser His Leu Glu Ser Ala Gly Tyr Tyr Leu Lys 
    450                 455                 460                 


Met Val Ile Ala His Thr Lys Ser Leu Asp Pro Ser Arg Pro Val Thr 
465                 470                 475                 480 


Phe Val Ser Asn Ser Asn Tyr Ala Ala Asp Lys Gly Ala Pro Tyr Val 
                485                 490                 495     


Asp Val Ile Cys Leu Asn Ser Tyr Tyr Ser Trp Tyr His Asp Tyr Gly 
            500                 505                 510         


His Leu Glu Leu Ile Gln Leu Gln Leu Ala Thr Gln Phe Glu Asn Trp 
        515                 520                 525             


Tyr Lys Lys Tyr Gln Lys Pro Ile Ile Gln Ser Glu Tyr Gly Ala Glu 
    530                 535                 540                 


Thr Ile Ala Gly Phe His Gln Asp Pro Pro Leu Met Phe Thr Glu Glu 
545                 550                 555                 560 


Tyr Gln Lys Ser Leu Leu Glu Gln Tyr His Leu Gly Leu Asp Gln Lys 
                565                 570                 575     


Arg Arg Lys Tyr Val Val Gly Glu Leu Ile Trp Asn Phe Ala Asp Phe 
            580                 585                 590         


Met Thr Glu Gln Ser Pro Thr Arg Val Leu Gly Asn Lys Lys Gly Ile 
        595                 600                 605             


Phe Thr Arg Gln Arg Gln Pro Lys Ser Ala Ala Phe Leu Leu Arg Glu 
    610                 615                 620                 


Arg Tyr Trp Lys Ile Ala Asn Glu Thr Arg Tyr Pro His Ser Val Ala 
625                 630                 635                 640 


Lys Ser Gln Cys Leu Glu Asn Ser Leu Phe Thr 
                645                 650     


<210>  5

<211>  745
<212>  PRT
<213>  homo sapiens

<220>
<223>  ABCD1 polypeptide sequence

<400>  5
Met Pro Val Leu Ser Arg Pro Arg Pro Trp Arg Gly Asn Thr Leu Lys 
1               5                   10                  15      


Arg Thr Ala Val Leu Leu Ala Leu Ala Ala Tyr Gly Ala His Lys Val 
            20                  25                  30          


Tyr Pro Leu Val Arg Gln Cys Leu Ala Pro Ala Arg Gly Leu Gln Ala 
        35                  40                  45              


Pro Ala Gly Glu Pro Thr Gln Glu Ala Ser Gly Val Ala Ala Ala Lys 
    50                  55                  60                  


Ala Gly Met Asn Arg Val Phe Leu Gln Arg Leu Leu Trp Leu Leu Arg 
65                  70                  75                  80  


Leu Leu Phe Pro Arg Val Leu Cys Arg Glu Thr Gly Leu Leu Ala Leu 
                85                  90                  95      


His Ser Ala Ala Leu Val Ser Arg Thr Phe Leu Ser Val Tyr Val Ala 
            100                 105                 110         


Arg Leu Asp Gly Arg Leu Ala Arg Cys Ile Val Arg Lys Asp Pro Arg 
        115                 120                 125             


Ala Phe Gly Trp Gln Leu Leu Gln Trp Leu Leu Ile Ala Leu Pro Ala 
    130                 135                 140                 


Thr Phe Val Asn Ser Ala Ile Arg Tyr Leu Glu Gly Gln Leu Ala Leu 
145                 150                 155                 160 


Ser Phe Arg Ser Arg Leu Val Ala His Ala Tyr Arg Leu Tyr Phe Ser 
                165                 170                 175     


Gln Gln Thr Tyr Tyr Arg Val Ser Asn Met Asp Gly Arg Leu Arg Asn 
            180                 185                 190         


Pro Asp Gln Ser Leu Thr Glu Asp Val Val Ala Phe Ala Ala Ser Val 
        195                 200                 205             


Ala His Leu Tyr Ser Asn Leu Thr Lys Pro Leu Leu Asp Val Ala Val 
    210                 215                 220                 


Thr Ser Tyr Thr Leu Leu Arg Ala Ala Arg Ser Arg Gly Ala Gly Thr 
225                 230                 235                 240 


Ala Trp Pro Ser Ala Ile Ala Gly Leu Val Val Phe Leu Thr Ala Asn 
                245                 250                 255     


Val Leu Arg Ala Phe Ser Pro Lys Phe Gly Glu Leu Val Ala Glu Glu 
            260                 265                 270         


Ala Arg Arg Lys Gly Glu Leu Arg Tyr Met His Ser Arg Val Val Ala 
        275                 280                 285             


Asn Ser Glu Glu Ile Ala Phe Tyr Gly Gly His Glu Val Glu Leu Ala 
    290                 295                 300                 


Leu Leu Gln Arg Ser Tyr Gln Asp Leu Ala Ser Gln Ile Asn Leu Ile 
305                 310                 315                 320 


Leu Leu Glu Arg Leu Trp Tyr Val Met Leu Glu Gln Phe Leu Met Lys 
                325                 330                 335     


Tyr Val Trp Ser Ala Ser Gly Leu Leu Met Val Ala Val Pro Ile Ile 
            340                 345                 350         


Thr Ala Thr Gly Tyr Ser Glu Ser Asp Ala Glu Ala Val Lys Lys Ala 
        355                 360                 365             


Ala Leu Glu Lys Lys Glu Glu Glu Leu Val Ser Glu Arg Thr Glu Ala 
    370                 375                 380                 


Phe Thr Ile Ala Arg Asn Leu Leu Thr Ala Ala Ala Asp Ala Ile Glu 
385                 390                 395                 400 


Arg Ile Met Ser Ser Tyr Lys Glu Val Thr Glu Leu Ala Gly Tyr Thr 
                405                 410                 415     


Ala Arg Val His Glu Met Phe Gln Val Phe Glu Asp Val Gln Arg Cys 
            420                 425                 430         


His Phe Lys Arg Pro Arg Glu Leu Glu Asp Ala Gln Ala Gly Ser Gly 
        435                 440                 445             


Thr Ile Gly Arg Ser Gly Val Arg Val Glu Gly Pro Leu Lys Ile Arg 
    450                 455                 460                 


Gly Gln Val Val Asp Val Glu Gln Gly Ile Ile Cys Glu Asn Ile Pro 
465                 470                 475                 480 


Ile Val Thr Pro Ser Gly Glu Val Val Val Ala Ser Leu Asn Ile Arg 
                485                 490                 495     


Val Glu Glu Gly Met His Leu Leu Ile Thr Gly Pro Asn Gly Cys Gly 
            500                 505                 510         


Lys Ser Ser Leu Phe Arg Ile Leu Gly Gly Leu Trp Pro Thr Tyr Gly 
        515                 520                 525             


Gly Val Leu Tyr Lys Pro Pro Pro Gln Arg Met Phe Tyr Ile Pro Gln 
    530                 535                 540                 


Arg Pro Tyr Met Ser Val Gly Ser Leu Arg Asp Gln Val Ile Tyr Pro 
545                 550                 555                 560 


Asp Ser Val Glu Asp Met Gln Arg Lys Gly Tyr Ser Glu Gln Asp Leu 
                565                 570                 575     


Glu Ala Ile Leu Asp Val Val His Leu His His Ile Leu Gln Arg Glu 
            580                 585                 590         


Gly Gly Trp Glu Ala Met Cys Asp Trp Lys Asp Val Leu Ser Gly Gly 
        595                 600                 605             


Glu Lys Gln Arg Ile Gly Met Ala Arg Met Phe Tyr His Arg Pro Lys 
    610                 615                 620                 


Tyr Ala Leu Leu Asp Glu Cys Thr Ser Ala Val Ser Ile Asp Val Glu 
625                 630                 635                 640 


Gly Lys Ile Phe Gln Ala Ala Lys Asp Ala Gly Ile Ala Leu Leu Ser 
                645                 650                 655     


Ile Thr His Arg Pro Ser Leu Trp Lys Tyr His Thr His Leu Leu Gln 
            660                 665                 670         


Phe Asp Gly Glu Gly Gly Trp Lys Phe Glu Lys Leu Asp Ser Ala Ala 
        675                 680                 685             


Arg Leu Ser Leu Thr Glu Glu Lys Gln Arg Leu Glu Gln Gln Leu Ala 
    690                 695                 700                 


Gly Ile Pro Lys Met Gln Arg Arg Leu Gln Glu Leu Cys Gln Ile Leu 
705                 710                 715                 720 


Gly Glu Ala Val Ala Pro Ala His Val Pro Ala Pro Ser Pro Gln Gly 
                725                 730                 735     


Pro Gly Gly Leu Gln Gly Ala Ser Thr 
            740                 745 


<210>  6

<211>  685
<212>  PRT
<213>  homo sapiens

<220>
<223>  GALC  polypeptide sequence

<400>  6
Met Ala Glu Trp Leu Leu Ser Ala Ser Trp Gln Arg Arg Ala Lys Ala 
1               5                   10                  15      


Met Thr Ala Ala Ala Gly Ser Ala Gly Arg Ala Ala Val Pro Leu Leu 
            20                  25                  30          


Leu Cys Ala Leu Leu Ala Pro Gly Gly Ala Tyr Val Leu Asp Asp Ser 
        35                  40                  45              


Asp Gly Leu Gly Arg Glu Phe Asp Gly Ile Gly Ala Val Ser Gly Gly 
    50                  55                  60                  


Gly Ala Thr Ser Arg Leu Leu Val Asn Tyr Pro Glu Pro Tyr Arg Ser 
65                  70                  75                  80  


Gln Ile Leu Asp Tyr Leu Phe Lys Pro Asn Phe Gly Ala Ser Leu His 
                85                  90                  95      


Ile Leu Lys Val Glu Ile Gly Gly Asp Gly Gln Thr Thr Asp Gly Thr 
            100                 105                 110         


Glu Pro Ser His Met His Tyr Ala Leu Asp Glu Asn Tyr Phe Arg Gly 
        115                 120                 125             


Tyr Glu Trp Trp Leu Met Lys Glu Ala Lys Lys Arg Asn Pro Asn Ile 
    130                 135                 140                 


Thr Leu Ile Gly Leu Pro Trp Ser Phe Pro Gly Trp Leu Gly Lys Gly 
145                 150                 155                 160 


Phe Asp Trp Pro Tyr Val Asn Leu Gln Leu Thr Ala Tyr Tyr Val Val 
                165                 170                 175     


Thr Trp Ile Val Gly Ala Lys Arg Tyr His Asp Leu Asp Ile Asp Tyr 
            180                 185                 190         


Ile Gly Ile Trp Asn Glu Arg Ser Tyr Asn Ala Asn Tyr Ile Lys Ile 
        195                 200                 205             


Leu Arg Lys Met Leu Asn Tyr Gln Gly Leu Gln Arg Val Lys Ile Ile 
    210                 215                 220                 


Ala Ser Asp Asn Leu Trp Glu Ser Ile Ser Ala Ser Met Leu Leu Asp 
225                 230                 235                 240 


Ala Glu Leu Phe Lys Val Val Asp Val Ile Gly Ala His Tyr Pro Gly 
                245                 250                 255     


Thr His Ser Ala Lys Asp Ala Lys Leu Thr Gly Lys Lys Leu Trp Ser 
            260                 265                 270         


Ser Glu Asp Phe Ser Thr Leu Asn Ser Asp Met Gly Ala Gly Cys Trp 
        275                 280                 285             


Gly Arg Ile Leu Asn Gln Asn Tyr Ile Asn Gly Tyr Met Thr Ser Thr 
    290                 295                 300                 


Ile Ala Trp Asn Leu Val Ala Ser Tyr Tyr Glu Gln Leu Pro Tyr Gly 
305                 310                 315                 320 


Arg Cys Gly Leu Met Thr Ala Gln Glu Pro Trp Ser Gly His Tyr Val 
                325                 330                 335     


Val Glu Ser Pro Val Trp Val Ser Ala His Thr Thr Gln Phe Thr Gln 
            340                 345                 350         


Pro Gly Trp Tyr Tyr Leu Lys Thr Val Gly His Leu Glu Lys Gly Gly 
        355                 360                 365             


Ser Tyr Val Ala Leu Thr Asp Gly Leu Gly Asn Leu Thr Ile Ile Ile 
    370                 375                 380                 


Glu Thr Met Ser His Lys His Ser Lys Cys Ile Arg Pro Phe Leu Pro 
385                 390                 395                 400 


Tyr Phe Asn Val Ser Gln Gln Phe Ala Thr Phe Val Leu Lys Gly Ser 
                405                 410                 415     


Phe Ser Glu Ile Pro Glu Leu Gln Val Trp Tyr Thr Lys Leu Gly Lys 
            420                 425                 430         


Thr Ser Glu Arg Phe Leu Phe Lys Gln Leu Asp Ser Leu Trp Leu Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Thr Leu Ser Leu His Glu Asp Glu Leu Phe 
    450                 455                 460                 


Thr Leu Thr Thr Leu Thr Thr Gly Arg Lys Gly Ser Tyr Pro Leu Pro 
465                 470                 475                 480 


Pro Lys Ser Gln Pro Phe Pro Ser Thr Tyr Lys Asp Asp Phe Asn Val 
                485                 490                 495     


Asp Tyr Pro Phe Phe Ser Glu Ala Pro Asn Phe Ala Asp Gln Thr Gly 
            500                 505                 510         


Val Phe Glu Tyr Phe Thr Asn Ile Glu Asp Pro Gly Glu His His Phe 
        515                 520                 525             


Thr Leu Arg Gln Val Leu Asn Gln Arg Pro Ile Thr Trp Ala Ala Asp 
    530                 535                 540                 


Ala Ser Asn Thr Ile Ser Ile Ile Gly Asp Tyr Asn Trp Thr Asn Leu 
545                 550                 555                 560 


Thr Ile Lys Cys Asp Val Tyr Ile Glu Thr Pro Asp Thr Gly Gly Val 
                565                 570                 575     


Phe Ile Ala Gly Arg Val Asn Lys Gly Gly Ile Leu Ile Arg Ser Ala 
            580                 585                 590         


Arg Gly Ile Phe Phe Trp Ile Phe Ala Asn Gly Ser Tyr Arg Val Thr 
        595                 600                 605             


Gly Asp Leu Ala Gly Trp Ile Ile Tyr Ala Leu Gly Arg Val Glu Val 
    610                 615                 620                 


Thr Ala Lys Lys Trp Tyr Thr Leu Thr Leu Thr Ile Lys Gly His Phe 
625                 630                 635                 640 


Thr Ser Gly Met Leu Asn Asp Lys Ser Leu Trp Thr Asp Ile Pro Val 
                645                 650                 655     


Asn Phe Pro Lys Asn Gly Trp Ala Ala Ile Gly Thr His Ser Phe Glu 
            660                 665                 670         


Phe Ala Gln Phe Asp Asn Phe Leu Val Glu Ala Thr Arg 
        675                 680                 685 


<210>  7

<211>  509
<212>  PRT
<213>  homo sapiens

<220>
<223>  ARSA  polypeptide sequence

<400>  7
Met Ser Met Gly Ala Pro Arg Ser Leu Leu Leu Ala Leu Ala Ala Gly 
1               5                   10                  15      


Leu Ala Val Ala Arg Pro Pro Asn Ile Val Leu Ile Phe Ala Asp Asp 
            20                  25                  30          


Leu Gly Tyr Gly Asp Leu Gly Cys Tyr Gly His Pro Ser Ser Thr Thr 
        35                  40                  45              


Pro Asn Leu Asp Gln Leu Ala Ala Gly Gly Leu Arg Phe Thr Asp Phe 
    50                  55                  60                  


Tyr Val Pro Val Ser Leu Cys Thr Pro Ser Arg Ala Ala Leu Leu Thr 
65                  70                  75                  80  


Gly Arg Leu Pro Val Arg Met Gly Met Tyr Pro Gly Val Leu Val Pro 
                85                  90                  95      


Ser Ser Arg Gly Gly Leu Pro Leu Glu Glu Val Thr Val Ala Glu Val 
            100                 105                 110         


Leu Ala Ala Arg Gly Tyr Leu Thr Gly Met Ala Gly Lys Trp His Leu 
        115                 120                 125             


Gly Val Gly Pro Glu Gly Ala Phe Leu Pro Pro His Gln Gly Phe His 
    130                 135                 140                 


Arg Phe Leu Gly Ile Pro Tyr Ser His Asp Gln Gly Pro Cys Gln Asn 
145                 150                 155                 160 


Leu Thr Cys Phe Pro Pro Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln 
                165                 170                 175     


Gly Leu Val Pro Ile Pro Leu Leu Ala Asn Leu Ser Val Glu Ala Gln 
            180                 185                 190         


Pro Pro Trp Leu Pro Gly Leu Glu Ala Arg Tyr Met Ala Phe Ala His 
        195                 200                 205             


Asp Leu Met Ala Asp Ala Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr 
    210                 215                 220                 


Tyr Ala Ser His His Thr His Tyr Pro Gln Phe Ser Gly Gln Ser Phe 
225                 230                 235                 240 


Ala Glu Arg Ser Gly Arg Gly Pro Phe Gly Asp Ser Leu Met Glu Leu 
                245                 250                 255     


Asp Ala Ala Val Gly Thr Leu Met Thr Ala Ile Gly Asp Leu Gly Leu 
            260                 265                 270         


Leu Glu Glu Thr Leu Val Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr 
        275                 280                 285             


Met Arg Met Ser Arg Gly Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys 
    290                 295                 300                 


Gly Thr Thr Tyr Glu Gly Gly Val Arg Glu Pro Ala Leu Ala Phe Trp 
305                 310                 315                 320 


Pro Gly His Ile Ala Pro Gly Val Thr His Glu Leu Ala Ser Ser Leu 
                325                 330                 335     


Asp Leu Leu Pro Thr Leu Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn 
            340                 345                 350         


Val Thr Leu Asp Gly Phe Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly 
        355                 360                 365             


Lys Ser Pro Arg Gln Ser Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu 
    370                 375                 380                 


Val Arg Gly Val Phe Ala Val Arg Thr Gly Lys Tyr Lys Ala His Phe 
385                 390                 395                 400 


Phe Thr Gln Gly Ser Ala His Ser Asp Thr Thr Ala Asp Pro Ala Cys 
                405                 410                 415     


His Ala Ser Ser Ser Leu Thr Ala His Glu Pro Pro Leu Leu Tyr Asp 
            420                 425                 430         


Leu Ser Lys Asp Pro Gly Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala 
        435                 440                 445             


Gly Ala Thr Pro Glu Val Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu 
    450                 455                 460                 


Lys Ala Gln Leu Asp Ala Ala Val Thr Phe Gly Pro Ser Gln Val Ala 
465                 470                 475                 480 


Arg Gly Glu Asp Pro Ala Leu Gln Ile Cys Cys His Pro Gly Cys Thr 
                485                 490                 495     


Pro Arg Pro Ala Cys Cys His Cys Pro Asp Pro His Ala 
            500                 505                 


<210>  8

<211>  527
<212>  PRT
<213>  homo sapiens

<220>
<223>  PSAP polypeptide sequence

<400>  8
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala 
1               5                   10                  15      


Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp 
            20                  25                  30          


Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys 
        35                  40                  45              


Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp 
    50                  55                  60                  


Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn 
65                  70                  75                  80  


Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp 
                85                  90                  95      


Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser 
            100                 105                 110         


Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro 
        115                 120                 125             


Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His 
    130                 135                 140                 


Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro 
145                 150                 155                 160 


Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro 
                165                 170                 175     


Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys 
            180                 185                 190         


Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile 
        195                 200                 205             


Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu 
    210                 215                 220                 


His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile 
225                 230                 235                 240 


Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met 
                245                 250                 255     


Met His Met Gln Asp Gln Gln Pro Lys Glu Ile Cys Ala Leu Val Gly 
            260                 265                 270         


Phe Cys Asp Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala 
        275                 280                 285             


Lys Val Ala Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro 
    290                 295                 300                 


Ile Lys Lys His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val 
305                 310                 315                 320 


Cys Glu Phe Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys 
                325                 330                 335     


Thr Glu Lys Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu 
            340                 345                 350         


Pro Lys Ser Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly 
        355                 360                 365             


Ser Ser Ile Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val 
    370                 375                 380                 


Cys Ser Met Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr 
385                 390                 395                 400 


Val His Val Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys 
                405                 410                 415     


Lys Leu Val Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys 
            420                 425                 430         


Gln Glu Ile Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp 
        435                 440                 445             


Pro Tyr Gln Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val 
    450                 455                 460                 


Leu Ile Glu Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu 
465                 470                 475                 480 


Lys Ile Gly Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu 
                485                 490                 495     


Lys Cys Ile Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala 
            500                 505                 510         


Ala Gln Cys Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn 
        515                 520                 525         


<210>  9

<211>  536
<212>  PRT
<213>  homo sapiens

<220>
<223>  GBA polypeptide sequence

<400>  9
Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  10

<211>  466
<212>  PRT
<213>  homo sapiens

<220>
<223>  FUCA1 polypeptide sequence

<400>  10
Met Arg Ala Pro Gly Met Arg Ser Arg Pro Ala Gly Pro Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Phe Leu Gly Ala Ala Glu Ser Val Arg Arg Ala Gln 
            20                  25                  30          


Pro Pro Arg Arg Tyr Thr Pro Asp Trp Pro Ser Leu Asp Ser Arg Pro 
        35                  40                  45              


Leu Pro Ala Trp Phe Asp Glu Ala Lys Phe Gly Val Phe Ile His Trp 
    50                  55                  60                  


Gly Val Phe Ser Val Pro Ala Trp Gly Ser Glu Trp Phe Trp Trp His 
65                  70                  75                  80  


Trp Gln Gly Glu Gly Arg Pro Gln Tyr Gln Arg Phe Met Arg Asp Asn 
                85                  90                  95      


Tyr Pro Pro Gly Phe Ser Tyr Ala Asp Phe Gly Pro Gln Phe Thr Ala 
            100                 105                 110         


Arg Phe Phe His Pro Glu Glu Trp Ala Asp Leu Phe Gln Ala Ala Gly 
        115                 120                 125             


Ala Lys Tyr Val Val Leu Thr Thr Lys His His Glu Gly Phe Thr Asn 
    130                 135                 140                 


Trp Pro Ser Pro Val Ser Trp Asn Trp Asn Ser Lys Asp Val Gly Pro 
145                 150                 155                 160 


His Arg Asp Leu Val Gly Glu Leu Gly Thr Ala Leu Arg Lys Arg Asn 
                165                 170                 175     


Ile Arg Tyr Gly Leu Tyr His Ser Leu Leu Glu Trp Phe His Pro Leu 
            180                 185                 190         


Tyr Leu Leu Asp Lys Lys Asn Gly Phe Lys Thr Gln His Phe Val Ser 
        195                 200                 205             


Ala Lys Thr Met Pro Glu Leu Tyr Asp Leu Val Asn Ser Tyr Lys Pro 
    210                 215                 220                 


Asp Leu Ile Trp Ser Asp Gly Glu Trp Glu Cys Pro Asp Thr Tyr Trp 
225                 230                 235                 240 


Asn Ser Thr Asn Phe Leu Ser Trp Leu Tyr Asn Asp Ser Pro Val Lys 
                245                 250                 255     


Asp Glu Val Val Val Asn Asp Arg Trp Gly Gln Asn Cys Ser Cys His 
            260                 265                 270         


His Gly Gly Tyr Tyr Asn Cys Glu Asp Lys Phe Lys Pro Gln Ser Leu 
        275                 280                 285             


Pro Asp His Lys Trp Glu Met Cys Thr Ser Ile Asp Lys Phe Ser Trp 
    290                 295                 300                 


Gly Tyr Arg Arg Asp Met Ala Leu Ser Asp Val Thr Glu Glu Ser Glu 
305                 310                 315                 320 


Ile Ile Ser Glu Leu Val Gln Thr Val Ser Leu Gly Gly Asn Tyr Leu 
                325                 330                 335     


Leu Asn Ile Gly Pro Thr Lys Asp Gly Leu Ile Val Pro Ile Phe Gln 
            340                 345                 350         


Glu Arg Leu Leu Ala Val Gly Lys Trp Leu Ser Ile Asn Gly Glu Ala 
        355                 360                 365             


Ile Tyr Ala Ser Lys Pro Trp Arg Val Gln Trp Glu Lys Asn Thr Thr 
    370                 375                 380                 


Ser Val Trp Tyr Thr Ser Lys Gly Ser Ala Val Tyr Ala Ile Phe Leu 
385                 390                 395                 400 


His Trp Pro Glu Asn Gly Val Leu Asn Leu Glu Ser Pro Ile Thr Thr 
                405                 410                 415     


Ser Thr Thr Lys Ile Thr Met Leu Gly Ile Gln Gly Asp Leu Lys Trp 
            420                 425                 430         


Ser Thr Asp Pro Asp Lys Gly Leu Phe Ile Ser Leu Pro Gln Leu Pro 
        435                 440                 445             


Pro Ser Ala Val Pro Ala Glu Phe Ala Trp Thr Ile Lys Leu Thr Gly 
    450                 455                 460                 


Val Lys 
465     


<210>  11

<211>  1011
<212>  PRT
<213>  homo sapiens

<220>
<223>  MAN2B1 polypeptide sequence

<400>  11
Met Gly Ala Tyr Ala Arg Ala Ser Gly Val Cys Ala Arg Gly Cys Leu 
1               5                   10                  15      


Asp Ser Ala Gly Pro Trp Thr Met Ser Arg Ala Leu Arg Pro Pro Leu 
            20                  25                  30          


Pro Pro Leu Cys Phe Phe Leu Leu Leu Leu Ala Ala Ala Gly Ala Arg 
        35                  40                  45              


Ala Gly Gly Tyr Glu Thr Cys Pro Thr Val Gln Pro Asn Met Leu Asn 
    50                  55                  60                  


Val His Leu Leu Pro His Thr His Asp Asp Val Gly Trp Leu Lys Thr 
65                  70                  75                  80  


Val Asp Gln Tyr Phe Tyr Gly Ile Lys Asn Asp Ile Gln His Ala Gly 
                85                  90                  95      


Val Gln Tyr Ile Leu Asp Ser Val Ile Ser Ala Leu Leu Ala Asp Pro 
            100                 105                 110         


Thr Arg Arg Phe Ile Tyr Val Glu Ile Ala Phe Phe Ser Arg Trp Trp 
        115                 120                 125             


His Gln Gln Thr Asn Ala Thr Gln Glu Val Val Arg Asp Leu Val Arg 
    130                 135                 140                 


Gln Gly Arg Leu Glu Phe Ala Asn Gly Gly Trp Val Met Asn Asp Glu 
145                 150                 155                 160 


Ala Ala Thr His Tyr Gly Ala Ile Val Asp Gln Met Thr Leu Gly Leu 
                165                 170                 175     


Arg Phe Leu Glu Asp Thr Phe Gly Asn Asp Gly Arg Pro Arg Val Ala 
            180                 185                 190         


Trp His Ile Asp Pro Phe Gly His Ser Arg Glu Gln Ala Ser Leu Phe 
        195                 200                 205             


Ala Gln Met Gly Phe Asp Gly Phe Phe Phe Gly Arg Leu Asp Tyr Gln 
    210                 215                 220                 


Asp Lys Trp Val Arg Met Gln Lys Leu Glu Met Glu Gln Val Trp Arg 
225                 230                 235                 240 


Ala Ser Thr Ser Leu Lys Pro Pro Thr Ala Asp Leu Phe Thr Gly Val 
                245                 250                 255     


Leu Pro Asn Gly Tyr Asn Pro Pro Arg Asn Leu Cys Trp Asp Val Leu 
            260                 265                 270         


Cys Val Asp Gln Pro Leu Val Glu Asp Pro Arg Ser Pro Glu Tyr Asn 
        275                 280                 285             


Ala Lys Glu Leu Val Asp Tyr Phe Leu Asn Val Ala Thr Ala Gln Gly 
    290                 295                 300                 


Arg Tyr Tyr Arg Thr Asn His Thr Val Met Thr Met Gly Ser Asp Phe 
305                 310                 315                 320 


Gln Tyr Glu Asn Ala Asn Met Trp Phe Lys Asn Leu Asp Lys Leu Ile 
                325                 330                 335     


Arg Leu Val Asn Ala Gln Gln Ala Lys Gly Ser Ser Val His Val Leu 
            340                 345                 350         


Tyr Ser Thr Pro Ala Cys Tyr Leu Trp Glu Leu Asn Lys Ala Asn Leu 
        355                 360                 365             


Thr Trp Ser Val Lys His Asp Asp Phe Phe Pro Tyr Ala Asp Gly Pro 
    370                 375                 380                 


His Gln Phe Trp Thr Gly Tyr Phe Ser Ser Arg Pro Ala Leu Lys Arg 
385                 390                 395                 400 


Tyr Glu Arg Leu Ser Tyr Asn Phe Leu Gln Val Cys Asn Gln Leu Glu 
                405                 410                 415     


Ala Leu Val Gly Leu Ala Ala Asn Val Gly Pro Tyr Gly Ser Gly Asp 
            420                 425                 430         


Ser Ala Pro Leu Asn Glu Ala Met Ala Val Leu Gln His His Asp Ala 
        435                 440                 445             


Val Ser Gly Thr Ser Arg Gln His Val Ala Asn Asp Tyr Ala Arg Gln 
    450                 455                 460                 


Leu Ala Ala Gly Trp Gly Pro Cys Glu Val Leu Leu Ser Asn Ala Leu 
465                 470                 475                 480 


Ala Arg Leu Arg Gly Phe Lys Asp His Phe Thr Phe Cys Gln Gln Leu 
                485                 490                 495     


Asn Ile Ser Ile Cys Pro Leu Ser Gln Thr Ala Ala Arg Phe Gln Val 
            500                 505                 510         


Ile Val Tyr Asn Pro Leu Gly Arg Lys Val Asn Trp Met Val Arg Leu 
        515                 520                 525             


Pro Val Ser Glu Gly Val Phe Val Val Lys Asp Pro Asn Gly Arg Thr 
    530                 535                 540                 


Val Pro Ser Asp Val Val Ile Phe Pro Ser Ser Asp Ser Gln Ala His 
545                 550                 555                 560 


Pro Pro Glu Leu Leu Phe Ser Ala Ser Leu Pro Ala Leu Gly Phe Ser 
                565                 570                 575     


Thr Tyr Ser Val Ala Gln Val Pro Arg Trp Lys Pro Gln Ala Arg Ala 
            580                 585                 590         


Pro Gln Pro Ile Pro Arg Arg Ser Trp Ser Pro Ala Leu Thr Ile Glu 
        595                 600                 605             


Asn Glu His Ile Arg Ala Thr Phe Asp Pro Asp Thr Gly Leu Leu Met 
    610                 615                 620                 


Glu Ile Met Asn Met Asn Gln Gln Leu Leu Leu Pro Val Arg Gln Thr 
625                 630                 635                 640 


Phe Phe Trp Tyr Asn Ala Ser Ile Gly Asp Asn Glu Ser Asp Gln Ala 
                645                 650                 655     


Ser Gly Ala Tyr Ile Phe Arg Pro Asn Gln Gln Lys Pro Leu Pro Val 
            660                 665                 670         


Ser Arg Trp Ala Gln Ile His Leu Val Lys Thr Pro Leu Val Gln Glu 
        675                 680                 685             


Val His Gln Asn Phe Ser Ala Trp Cys Ser Gln Val Val Arg Leu Tyr 
    690                 695                 700                 


Pro Gly Gln Arg His Leu Glu Leu Glu Trp Ser Val Gly Pro Ile Pro 
705                 710                 715                 720 


Val Gly Asp Thr Trp Gly Lys Glu Val Ile Ser Arg Phe Asp Thr Pro 
                725                 730                 735     


Leu Glu Thr Lys Gly Arg Phe Tyr Thr Asp Ser Asn Gly Arg Glu Ile 
            740                 745                 750         


Leu Glu Arg Arg Arg Asp Tyr Arg Pro Thr Trp Lys Leu Asn Gln Thr 
        755                 760                 765             


Glu Pro Val Ala Gly Asn Tyr Tyr Pro Val Asn Thr Arg Ile Tyr Ile 
    770                 775                 780                 


Thr Asp Gly Asn Met Gln Leu Thr Val Leu Thr Asp Arg Ser Gln Gly 
785                 790                 795                 800 


Gly Ser Ser Leu Arg Asp Gly Ser Leu Glu Leu Met Val His Arg Arg 
                805                 810                 815     


Leu Leu Lys Asp Asp Gly Arg Gly Val Ser Glu Pro Leu Met Glu Asn 
            820                 825                 830         


Gly Ser Gly Ala Trp Val Arg Gly Arg His Leu Val Leu Leu Asp Thr 
        835                 840                 845             


Ala Gln Ala Ala Ala Ala Gly His Arg Leu Leu Ala Glu Gln Glu Val 
    850                 855                 860                 


Leu Ala Pro Gln Val Val Leu Ala Pro Gly Gly Gly Ala Ala Tyr Asn 
865                 870                 875                 880 


Leu Gly Ala Pro Pro Arg Thr Gln Phe Ser Gly Leu Arg Arg Asp Leu 
                885                 890                 895     


Pro Pro Ser Val His Leu Leu Thr Leu Ala Ser Trp Gly Pro Glu Met 
            900                 905                 910         


Val Leu Leu Arg Leu Glu His Gln Phe Ala Val Gly Glu Asp Ser Gly 
        915                 920                 925             


Arg Asn Leu Ser Ala Pro Val Thr Leu Asn Leu Arg Asp Leu Phe Ser 
    930                 935                 940                 


Thr Phe Thr Ile Thr Arg Leu Gln Glu Thr Thr Leu Val Ala Asn Gln 
945                 950                 955                 960 


Leu Arg Glu Ala Ala Ser Arg Leu Lys Trp Thr Thr Asn Thr Gly Pro 
                965                 970                 975     


Thr Pro His Gln Thr Pro Tyr Gln Leu Asp Pro Ala Asn Ile Thr Leu 
            980                 985                 990         


Glu Pro Met Glu Ile Arg Thr Phe Leu Ala Ser Val Gln Trp Lys Glu 
        995                 1000                1005            


Val Asp Gly 
    1010    


<210>  12

<211>  346
<212>  PRT
<213>  homo sapiens

<220>
<223>  AGA polypeptide sequence

<400>  12
Met Ala Arg Lys Ser Asn Leu Pro Val Leu Leu Val Pro Phe Leu Leu 
1               5                   10                  15      


Cys Gln Ala Leu Val Arg Cys Ser Ser Pro Leu Pro Leu Val Val Asn 
            20                  25                  30          


Thr Trp Pro Phe Lys Asn Ala Thr Glu Ala Ala Trp Arg Ala Leu Ala 
        35                  40                  45              


Ser Gly Gly Ser Ala Leu Asp Ala Val Glu Ser Gly Cys Ala Met Cys 
    50                  55                  60                  


Glu Arg Glu Gln Cys Asp Gly Ser Val Gly Phe Gly Gly Ser Pro Asp 
65                  70                  75                  80  


Glu Leu Gly Glu Thr Thr Leu Asp Ala Met Ile Met Asp Gly Thr Thr 
                85                  90                  95      


Met Asp Val Gly Ala Val Gly Asp Leu Arg Arg Ile Lys Asn Ala Ile 
            100                 105                 110         


Gly Val Ala Arg Lys Val Leu Glu His Thr Thr His Thr Leu Leu Val 
        115                 120                 125             


Gly Glu Ser Ala Thr Thr Phe Ala Gln Ser Met Gly Phe Ile Asn Glu 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ala Ser Gln Ala Leu His Ser Asp Trp Leu Ala 
145                 150                 155                 160 


Arg Asn Cys Gln Pro Asn Tyr Trp Arg Asn Val Ile Pro Asp Pro Ser 
                165                 170                 175     


Lys Tyr Cys Gly Pro Tyr Lys Pro Pro Gly Ile Leu Lys Gln Asp Ile 
            180                 185                 190         


Pro Ile His Lys Glu Thr Glu Asp Asp Arg Gly His Asp Thr Ile Gly 
        195                 200                 205             


Met Val Val Ile His Lys Thr Gly His Ile Ala Ala Gly Thr Ser Thr 
    210                 215                 220                 


Asn Gly Ile Lys Phe Lys Ile His Gly Arg Val Gly Asp Ser Pro Ile 
225                 230                 235                 240 


Pro Gly Ala Gly Ala Tyr Ala Asp Asp Thr Ala Gly Ala Ala Ala Ala 
                245                 250                 255     


Thr Gly Asn Gly Asp Ile Leu Met Arg Phe Leu Pro Ser Tyr Gln Ala 
            260                 265                 270         


Val Glu Tyr Met Arg Arg Gly Glu Asp Pro Thr Ile Ala Cys Gln Lys 
        275                 280                 285             


Val Ile Ser Arg Ile Gln Lys His Phe Pro Glu Phe Phe Gly Ala Val 
    290                 295                 300                 


Ile Cys Ala Asn Val Thr Gly Ser Tyr Gly Ala Ala Cys Asn Lys Leu 
305                 310                 315                 320 


Ser Thr Phe Thr Gln Phe Ser Phe Met Val Tyr Asn Ser Glu Lys Asn 
                325                 330                 335     


Gln Pro Thr Glu Glu Lys Val Asp Cys Ile 
            340                 345     


<210>  13

<211>  411
<212>  PRT
<213>  homo sapiens

<220>
<223>  ASAH1 polypeptide sequence

<400>  13
Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Trp Thr Glu Asp Cys Arg 
        35                  40                  45              


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
    50                  55                  60                  


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
65                  70                  75                  80  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
                85                  90                  95      


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
            100                 105                 110         


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
        115                 120                 125             


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly 
    130                 135                 140                 


Glu Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr 
145                 150                 155                 160 


Ser Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn 
                165                 170                 175     


Met Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp 
            180                 185                 190         


Val Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln 
        195                 200                 205             


Arg Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val 
    210                 215                 220                 


Gly Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn 
225                 230                 235                 240 


Glu Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile 
                245                 250                 255     


Leu Gly Lys Lys Asp Val Met Trp Ile Gly Phe Leu Thr Arg Thr Val 
            260                 265                 270         


Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys 
        275                 280                 285             


Thr Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser 
    290                 295                 300                 


Gly Glu Gly Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val 
305                 310                 315                 320 


Tyr Glu Leu Asp Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn 
                325                 330                 335     


Tyr Asp Arg Trp Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro 
            340                 345                 350         


Ala Lys Met Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu 
        355                 360                 365             


Thr Met Tyr Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr 
    370                 375                 380                 


Val Tyr Thr Thr Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr 
385                 390                 395                 400 


Leu Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp 
                405                 410     


<210>  14

<211>  529
<212>  PRT
<213>  homo sapiens

<220>
<223>  HEXA polypeptide sequence

<400>  14
Met Thr Ser Ser Arg Leu Trp Phe Ser Leu Leu Leu Ala Ala Ala Phe 
1               5                   10                  15      


Ala Gly Arg Ala Thr Ala Leu Trp Pro Trp Pro Gln Asn Phe Gln Thr 
            20                  25                  30          


Ser Asp Gln Arg Tyr Val Leu Tyr Pro Asn Asn Phe Gln Phe Gln Tyr 
        35                  40                  45              


Asp Val Ser Ser Ala Ala Gln Pro Gly Cys Ser Val Leu Asp Glu Ala 
    50                  55                  60                  


Phe Gln Arg Tyr Arg Asp Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg 
65                  70                  75                  80  


Pro Tyr Leu Thr Gly Lys Arg His Thr Leu Glu Lys Asn Val Leu Val 
                85                  90                  95      


Val Ser Val Val Thr Pro Gly Cys Asn Gln Leu Pro Thr Leu Glu Ser 
            100                 105                 110         


Val Glu Asn Tyr Thr Leu Thr Ile Asn Asp Asp Gln Cys Leu Leu Leu 
        115                 120                 125             


Ser Glu Thr Val Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser Gln 
    130                 135                 140                 


Leu Val Trp Lys Ser Ala Glu Gly Thr Phe Phe Ile Asn Lys Thr Glu 
145                 150                 155                 160 


Ile Glu Asp Phe Pro Arg Phe Pro His Arg Gly Leu Leu Leu Asp Thr 
                165                 170                 175     


Ser Arg His Tyr Leu Pro Leu Ser Ser Ile Leu Asp Thr Leu Asp Val 
            180                 185                 190         


Met Ala Tyr Asn Lys Leu Asn Val Phe His Trp His Leu Val Asp Asp 
        195                 200                 205             


Pro Ser Phe Pro Tyr Glu Ser Phe Thr Phe Pro Glu Leu Met Arg Lys 
    210                 215                 220                 


Gly Ser Tyr Asn Pro Val Thr His Ile Tyr Thr Ala Gln Asp Val Lys 
225                 230                 235                 240 


Glu Val Ile Glu Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Ala Glu 
                245                 250                 255     


Phe Asp Thr Pro Gly His Thr Leu Ser Trp Gly Pro Gly Ile Pro Gly 
            260                 265                 270         


Leu Leu Thr Pro Cys Tyr Ser Gly Ser Glu Pro Ser Gly Thr Phe Gly 
        275                 280                 285             


Pro Val Asn Pro Ser Leu Asn Asn Thr Tyr Glu Phe Met Ser Thr Phe 
    290                 295                 300                 


Phe Leu Glu Val Ser Ser Val Phe Pro Asp Phe Tyr Leu His Leu Gly 
305                 310                 315                 320 


Gly Asp Glu Val Asp Phe Thr Cys Trp Lys Ser Asn Pro Glu Ile Gln 
                325                 330                 335     


Asp Phe Met Arg Lys Lys Gly Phe Gly Glu Asp Phe Lys Gln Leu Glu 
            340                 345                 350         


Ser Phe Tyr Ile Gln Thr Leu Leu Asp Ile Val Ser Ser Tyr Gly Lys 
        355                 360                 365             


Gly Tyr Val Val Trp Gln Glu Val Phe Asp Asn Lys Val Lys Ile Gln 
    370                 375                 380                 


Pro Asp Thr Ile Ile Gln Val Trp Arg Glu Asp Ile Pro Val Asn Tyr 
385                 390                 395                 400 


Met Lys Glu Leu Glu Leu Val Thr Lys Ala Gly Phe Arg Ala Leu Leu 
                405                 410                 415     


Ser Ala Pro Trp Tyr Leu Asn Arg Ile Ser Tyr Gly Pro Asp Trp Lys 
            420                 425                 430         


Asp Phe Tyr Ile Val Glu Pro Leu Ala Phe Glu Gly Thr Pro Glu Gln 
        435                 440                 445             


Lys Ala Leu Val Ile Gly Gly Glu Ala Cys Met Trp Gly Glu Tyr Val 
    450                 455                 460                 


Asp Asn Thr Asn Leu Val Pro Arg Leu Trp Pro Arg Ala Gly Ala Val 
465                 470                 475                 480 


Ala Glu Arg Leu Trp Ser Asn Lys Leu Thr Ser Asp Leu Thr Phe Ala 
                485                 490                 495     


Tyr Glu Arg Leu Ser His Phe Arg Cys Glu Leu Leu Arg Arg Gly Val 
            500                 505                 510         


Gln Ala Gln Pro Leu Asn Val Gly Phe Cys Glu Gln Glu Phe Glu Gln 
        515                 520                 525             


Thr 
    


<210>  15

<211>  952
<212>  PRT
<213>  homo sapiens

<220>
<223>  GAA polypeptide sequence

<400>  15
Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  16

<211>  631
<212>  PRT
<213>  homo sapiens

<220>
<223>  SMPD1 polypeptide sequence

<400>  16
Met Pro Arg Tyr Gly Ala Ser Leu Arg Gln Ser Cys Pro Arg Ser Gly 
1               5                   10                  15      


Arg Glu Gln Gly Gln Asp Gly Thr Ala Gly Ala Pro Gly Leu Leu Trp 
            20                  25                  30          


Met Gly Leu Val Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala 
        35                  40                  45              


Leu Ser Asp Ser Arg Val Leu Trp Ala Pro Ala Glu Ala His Pro Leu 
    50                  55                  60                  


Ser Pro Gln Gly His Pro Ala Arg Leu His Arg Ile Val Pro Arg Leu 
65                  70                  75                  80  


Arg Asp Val Phe Gly Trp Gly Asn Leu Thr Cys Pro Ile Cys Lys Gly 
                85                  90                  95      


Leu Phe Thr Ala Ile Asn Leu Gly Leu Lys Lys Glu Pro Asn Val Ala 
            100                 105                 110         


Arg Val Gly Ser Val Ala Ile Lys Leu Cys Asn Leu Leu Lys Ile Ala 
        115                 120                 125             


Pro Pro Ala Val Cys Gln Ser Ile Val His Leu Phe Glu Asp Asp Met 
    130                 135                 140                 


Val Glu Val Trp Arg Arg Ser Val Leu Ser Pro Ser Glu Ala Cys Gly 
145                 150                 155                 160 


Leu Leu Leu Gly Ser Thr Cys Gly His Trp Asp Ile Phe Ser Ser Trp 
                165                 170                 175     


Asn Ile Ser Leu Pro Thr Val Pro Lys Pro Pro Pro Lys Pro Pro Ser 
            180                 185                 190         


Pro Pro Ala Pro Gly Ala Pro Val Ser Arg Ile Leu Phe Leu Thr Asp 
        195                 200                 205             


Leu His Trp Asp His Asp Tyr Leu Glu Gly Thr Asp Pro Asp Cys Ala 
    210                 215                 220                 


Asp Pro Leu Cys Cys Arg Arg Gly Ser Gly Leu Pro Pro Ala Ser Arg 
225                 230                 235                 240 


Pro Gly Ala Gly Tyr Trp Gly Glu Tyr Ser Lys Cys Asp Leu Pro Leu 
                245                 250                 255     


Arg Thr Leu Glu Ser Leu Leu Ser Gly Leu Gly Pro Ala Gly Pro Phe 
            260                 265                 270         


Asp Met Val Tyr Trp Thr Gly Asp Ile Pro Ala His Asp Val Trp His 
        275                 280                 285             


Gln Thr Arg Gln Asp Gln Leu Arg Ala Leu Thr Thr Val Thr Ala Leu 
    290                 295                 300                 


Val Arg Lys Phe Leu Gly Pro Val Pro Val Tyr Pro Ala Val Gly Asn 
305                 310                 315                 320 


His Glu Ser Thr Pro Val Asn Ser Phe Pro Pro Pro Phe Ile Glu Gly 
                325                 330                 335     


Asn His Ser Ser Arg Trp Leu Tyr Glu Ala Met Ala Lys Ala Trp Glu 
            340                 345                 350         


Pro Trp Leu Pro Ala Glu Ala Leu Arg Thr Leu Arg Ile Gly Gly Phe 
        355                 360                 365             


Tyr Ala Leu Ser Pro Tyr Pro Gly Leu Arg Leu Ile Ser Leu Asn Met 
    370                 375                 380                 


Asn Phe Cys Ser Arg Glu Asn Phe Trp Leu Leu Ile Asn Ser Thr Asp 
385                 390                 395                 400 


Pro Ala Gly Gln Leu Gln Trp Leu Val Gly Glu Leu Gln Ala Ala Glu 
                405                 410                 415     


Asp Arg Gly Asp Lys Val His Ile Ile Gly His Ile Pro Pro Gly His 
            420                 425                 430         


Cys Leu Lys Ser Trp Ser Trp Asn Tyr Tyr Arg Ile Val Ala Arg Tyr 
        435                 440                 445             


Glu Asn Thr Leu Ala Ala Gln Phe Phe Gly His Thr His Val Asp Glu 
    450                 455                 460                 


Phe Glu Val Phe Tyr Asp Glu Glu Thr Leu Ser Arg Pro Leu Ala Val 
465                 470                 475                 480 


Ala Phe Leu Ala Pro Ser Ala Thr Thr Tyr Ile Gly Leu Asn Pro Gly 
                485                 490                 495     


Tyr Arg Val Tyr Gln Ile Asp Gly Asn Tyr Ser Gly Ser Ser His Val 
            500                 505                 510         


Val Leu Asp His Glu Thr Tyr Ile Leu Asn Leu Thr Gln Ala Asn Ile 
        515                 520                 525             


Pro Gly Ala Ile Pro His Trp Gln Leu Leu Tyr Arg Ala Arg Glu Thr 
    530                 535                 540                 


Tyr Gly Leu Pro Asn Thr Leu Pro Thr Ala Trp His Asn Leu Val Tyr 
545                 550                 555                 560 


Arg Met Arg Gly Asp Met Gln Leu Phe Gln Thr Phe Trp Phe Leu Tyr 
                565                 570                 575     


His Lys Gly His Pro Pro Ser Glu Pro Cys Gly Thr Pro Cys Arg Leu 
            580                 585                 590         


Ala Thr Leu Cys Ala Gln Leu Ser Ala Arg Ala Asp Ser Pro Ala Leu 
        595                 600                 605             


Cys Arg His Leu Met Pro Asp Gly Ser Leu Pro Glu Ala Gln Ser Leu 
    610                 615                 620                 


Trp Pro Arg Pro Leu Phe Cys 
625                 630     


<210>  17

<211>  399
<212>  PRT
<213>  homo sapiens

<220>
<223>  LIPA polypeptide sequence

<400>  17
Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Thr 
1               5                   10                  15      


Leu His Ser Glu Gly Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu 
            20                  25                  30          


Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser 
        35                  40                  45              


Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
    50                  55                  60                  


Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro 
65                  70                  75                  80  


Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
                85                  90                  95      


Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
            100                 105                 110         


Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
        115                 120                 125             


His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
    130                 135                 140                 


Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
145                 150                 155                 160 


Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
                165                 170                 175     


Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
            180                 185                 190         


Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
        195                 200                 205             


Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile 
    210                 215                 220                 


Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu 
225                 230                 235                 240 


Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu 
                245                 250                 255     


Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu 
            260                 265                 270         


Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr 
        275                 280                 285             


Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys 
    290                 295                 300                 


Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr 
305                 310                 315                 320 


Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro 
                325                 330                 335     


Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp 
            340                 345                 350         


Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser 
        355                 360                 365             


Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro 
    370                 375                 380                 


Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
385                 390                 395                 


<210>  18

<211>  1030
<212>  PRT
<213>  homo sapiens

<220>
<223>  CDKL5 polypeptide sequence

<400>  18
Met Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
1               5                   10                  15      


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
            20                  25                  30          


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
        35                  40                  45              


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
    50                  55                  60                  


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
                85                  90                  95      


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
            100                 105                 110         


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
        115                 120                 125             


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
    130                 135                 140                 


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
145                 150                 155                 160 


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
                165                 170                 175     


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
            180                 185                 190         


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
        195                 200                 205             


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
    210                 215                 220                 


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
225                 230                 235                 240 


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
                245                 250                 255     


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
            260                 265                 270         


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
        275                 280                 285             


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
    290                 295                 300                 


Arg Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser 
305                 310                 315                 320 


Ser Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln 
                325                 330                 335     


Ser His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly 
            340                 345                 350         


Leu Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn 
        355                 360                 365             


Gly Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr 
    370                 375                 380                 


Gln Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn 
385                 390                 395                 400 


Asn Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu 
                405                 410                 415     


Phe Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys 
            420                 425                 430         


Tyr Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met 
        435                 440                 445             


Glu Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln 
    450                 455                 460                 


Ser Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro 
465                 470                 475                 480 


Ser Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys 
                485                 490                 495     


Ser Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser 
            500                 505                 510         


Thr Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr 
        515                 520                 525             


Ser Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro 
    530                 535                 540                 


Ser Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr 
545                 550                 555                 560 


Thr Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His 
                565                 570                 575     


Met Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe 
            580                 585                 590         


Ser Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro 
        595                 600                 605             


His Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly 
    610                 615                 620                 


Leu Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn 
625                 630                 635                 640 


Ser Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu 
                645                 650                 655     


Met Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr 
            660                 665                 670         


Ser Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp 
        675                 680                 685             


Pro His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr 
    690                 695                 700                 


Asn Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser 
705                 710                 715                 720 


Pro Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val 
                725                 730                 735     


Ser Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg 
            740                 745                 750         


Gln Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser 
        755                 760                 765             


Glu Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys 
    770                 775                 780                 


Lys Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp 
785                 790                 795                 800 


Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser 
                805                 810                 815     


Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln 
            820                 825                 830         


Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala 
        835                 840                 845             


Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala 
    850                 855                 860                 


Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser 
865                 870                 875                 880 


Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys 
                885                 890                 895     


Gly Arg Pro Ala Leu Gln Leu Pro Asp Gly Gly Cys Asp Gly Arg Arg 
            900                 905                 910         


Gln Arg His His Ser Gly Pro Gln Asp Arg Arg Phe Met Leu Arg Thr 
        915                 920                 925             


Thr Glu Gln Gln Gly Glu Tyr Phe Cys Cys Gly Asp Pro Lys Lys Pro 
    930                 935                 940                 


His Thr Pro Cys Val Pro Asn Arg Ala Leu His Arg Pro Ile Ser Ser 
945                 950                 955                 960 


Pro Ala Pro Tyr Pro Val Leu Gln Val Arg Gly Thr Ser Met Cys Pro 
                965                 970                 975     


Thr Leu Gln Val Arg Gly Thr Asp Ala Phe Ser Cys Pro Thr Gln Gln 
            980                 985                 990         


Ser Gly Phe Ser Phe Phe Val Arg His Val Met Arg Glu Ala Leu Ile 
        995                 1000                1005            


His Arg Ala Gln Val Asn Gln Ala Ala Leu Leu Thr Tyr His Glu Asn 
    1010                1015                1020                


Ala Ala Leu Thr Gly Lys 
1025                1030


<210>  19

<211>  147
<212>  PRT
<213>  homo sapiens

<220>
<223>  HBB

<400>  19
Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  20

<211>  261
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD40L

<400>  20
Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  21

<211>  1144
<212>  PRT
<213>  homo sapiens

<220>
<223>  ADCY3

<400>  21
Met Pro Arg Asn Gln Gly Phe Ser Glu Pro Glu Tyr Ser Ala Glu Tyr 
1               5                   10                  15      


Ser Ala Glu Tyr Ser Val Ser Leu Pro Ser Asp Pro Asp Arg Gly Val 
            20                  25                  30          


Gly Arg Thr His Glu Ile Ser Val Arg Asn Ser Gly Ser Cys Leu Cys 
        35                  40                  45              


Leu Pro Arg Phe Met Arg Leu Thr Phe Val Pro Glu Ser Leu Glu Asn 
    50                  55                  60                  


Leu Tyr Gln Thr Tyr Phe Lys Arg Gln Arg His Glu Thr Leu Leu Val 
65                  70                  75                  80  


Leu Val Val Phe Ala Ala Leu Phe Asp Cys Tyr Val Val Val Met Cys 
                85                  90                  95      


Ala Val Val Phe Ser Ser Asp Lys Leu Ala Ser Leu Ala Val Ala Gly 
            100                 105                 110         


Ile Gly Leu Val Leu Asp Ile Ile Leu Phe Val Leu Cys Lys Lys Gly 
        115                 120                 125             


Leu Leu Pro Asp Arg Val Thr Arg Arg Val Leu Pro Tyr Val Leu Trp 
    130                 135                 140                 


Leu Leu Ile Thr Ala Gln Ile Phe Ser Tyr Leu Gly Leu Asn Phe Ala 
145                 150                 155                 160 


Arg Ala His Ala Ala Ser Asp Thr Val Gly Trp Gln Val Phe Phe Val 
                165                 170                 175     


Phe Ser Phe Phe Ile Thr Leu Pro Leu Ser Leu Ser Pro Ile Val Ile 
            180                 185                 190         


Ile Ser Val Val Ser Cys Val Val His Thr Leu Val Leu Gly Val Thr 
        195                 200                 205             


Val Ala Gln Gln Gln Gln Glu Glu Leu Lys Gly Met Gln Leu Leu Arg 
    210                 215                 220                 


Glu Ile Leu Ala Asn Val Phe Leu Tyr Leu Cys Ala Ile Ala Val Gly 
225                 230                 235                 240 


Ile Met Ser Tyr Tyr Met Ala Asp Arg Lys His Arg Lys Ala Phe Leu 
                245                 250                 255     


Glu Ala Arg Gln Ser Leu Glu Val Lys Met Asn Leu Glu Glu Gln Ser 
            260                 265                 270         


Gln Gln Gln Glu Asn Leu Met Leu Ser Ile Leu Pro Lys His Val Ala 
        275                 280                 285             


Asp Glu Met Leu Lys Asp Met Lys Lys Asp Glu Ser Gln Lys Asp Gln 
    290                 295                 300                 


Gln Gln Phe Asn Thr Met Tyr Met Tyr Arg His Glu Asn Val Ser Ile 
305                 310                 315                 320 


Leu Phe Ala Asp Ile Val Gly Phe Thr Gln Leu Ser Ser Ala Cys Ser 
                325                 330                 335     


Ala Gln Glu Leu Val Lys Leu Leu Asn Glu Leu Phe Ala Arg Phe Asp 
            340                 345                 350         


Lys Leu Ala Ala Lys Tyr His Gln Leu Arg Ile Lys Ile Leu Gly Asp 
        355                 360                 365             


Cys Tyr Tyr Cys Ile Cys Gly Leu Pro Asp Tyr Arg Glu Asp His Ala 
    370                 375                 380                 


Val Cys Ser Ile Leu Met Gly Leu Ala Met Val Glu Ala Ile Ser Tyr 
385                 390                 395                 400 


Val Arg Glu Lys Thr Lys Thr Gly Val Asp Met Arg Val Gly Val His 
                405                 410                 415     


Thr Gly Thr Val Leu Gly Gly Val Leu Gly Gln Lys Arg Trp Gln Tyr 
            420                 425                 430         


Asp Val Trp Ser Thr Asp Val Thr Val Ala Asn Lys Met Glu Ala Gly 
        435                 440                 445             


Gly Ile Pro Gly Arg Val His Ile Ser Gln Ser Thr Met Asp Cys Leu 
    450                 455                 460                 


Lys Gly Glu Phe Asp Val Glu Pro Gly Asp Gly Gly Ser Arg Cys Asp 
465                 470                 475                 480 


Tyr Leu Glu Glu Lys Gly Ile Glu Thr Tyr Leu Ile Ile Ala Ser Lys 
                485                 490                 495     


Pro Glu Val Lys Lys Thr Ala Thr Gln Asn Gly Leu Asn Gly Ser Ala 
            500                 505                 510         


Leu Pro Asn Gly Ala Pro Ala Ser Ser Lys Ser Ser Ser Pro Ala Leu 
        515                 520                 525             


Ile Glu Thr Lys Glu Pro Asn Gly Ser Ala His Ser Ser Gly Ser Thr 
    530                 535                 540                 


Ser Glu Lys Pro Glu Glu Gln Asp Ala Gln Ala Asp Asn Pro Ser Phe 
545                 550                 555                 560 


Pro Asn Pro Arg Arg Arg Leu Arg Leu Gln Asp Leu Ala Asp Arg Val 
                565                 570                 575     


Val Asp Ala Ser Glu Asp Glu His Glu Leu Asn Gln Leu Leu Asn Glu 
            580                 585                 590         


Ala Leu Leu Glu Arg Glu Ser Ala Gln Val Val Lys Lys Arg Asn Thr 
        595                 600                 605             


Phe Leu Leu Ser Met Arg Phe Met Asp Pro Glu Met Glu Thr Arg Tyr 
    610                 615                 620                 


Ser Val Glu Lys Glu Lys Gln Ser Gly Ala Ala Phe Ser Cys Ser Cys 
625                 630                 635                 640 


Val Val Leu Leu Cys Thr Ala Leu Val Glu Ile Leu Ile Asp Pro Trp 
                645                 650                 655     


Leu Met Thr Asn Tyr Val Thr Phe Met Val Gly Glu Ile Leu Leu Leu 
            660                 665                 670         


Ile Leu Thr Ile Cys Ser Leu Ala Ala Ile Phe Pro Arg Ala Phe Pro 
        675                 680                 685             


Lys Lys Leu Val Ala Phe Ser Thr Trp Ile Asp Arg Thr Arg Trp Ala 
    690                 695                 700                 


Arg Asn Thr Trp Ala Met Leu Ala Ile Phe Ile Leu Val Met Ala Asn 
705                 710                 715                 720 


Val Val Asp Met Leu Ser Cys Leu Gln Tyr Tyr Thr Gly Pro Ser Asn 
                725                 730                 735     


Ala Thr Ala Gly Met Glu Thr Glu Gly Ser Cys Leu Glu Asn Pro Lys 
            740                 745                 750         


Tyr Tyr Asn Tyr Val Ala Val Leu Ser Leu Ile Ala Thr Ile Met Leu 
        755                 760                 765             


Val Gln Val Ser His Met Val Lys Leu Thr Leu Met Leu Leu Val Ala 
    770                 775                 780                 


Gly Ala Val Ala Thr Ile Asn Leu Tyr Ala Trp Arg Pro Val Phe Asp 
785                 790                 795                 800 


Glu Tyr Asp His Lys Arg Phe Arg Glu His Asp Leu Pro Met Val Ala 
                805                 810                 815     


Leu Glu Gln Met Gln Gly Phe Asn Pro Gly Leu Asn Gly Thr Asp Arg 
            820                 825                 830         


Leu Pro Leu Val Pro Ser Lys Tyr Ser Met Thr Val Met Val Phe Leu 
        835                 840                 845             


Met Met Leu Ser Phe Tyr Tyr Phe Ser Arg His Val Glu Lys Leu Ala 
    850                 855                 860                 


Arg Thr Leu Phe Leu Trp Lys Ile Glu Val His Asp Gln Lys Glu Arg 
865                 870                 875                 880 


Val Tyr Glu Met Arg Arg Trp Asn Glu Ala Leu Val Thr Asn Met Leu 
                885                 890                 895     


Pro Glu His Val Ala Arg His Phe Leu Gly Ser Lys Lys Arg Asp Glu 
            900                 905                 910         


Glu Leu Tyr Ser Gln Thr Tyr Asp Glu Ile Gly Val Met Phe Ala Ser 
        915                 920                 925             


Leu Pro Asn Phe Ala Asp Phe Tyr Thr Glu Glu Ser Ile Asn Asn Gly 
    930                 935                 940                 


Gly Ile Glu Cys Leu Arg Phe Leu Asn Glu Ile Ile Ser Asp Phe Asp 
945                 950                 955                 960 


Ser Leu Leu Asp Asn Pro Lys Phe Arg Val Ile Thr Lys Ile Lys Thr 
                965                 970                 975     


Ile Gly Ser Thr Tyr Met Ala Ala Ser Gly Val Thr Pro Asp Val Asn 
            980                 985                 990         


Thr Asn Gly Phe Ala Ser Ser Asn Lys Glu Asp Lys Ser Glu Arg Glu 
        995                 1000                1005            


Arg Trp Gln His Leu Ala Asp Leu Ala Asp Phe Ala Leu Ala Met Lys 
    1010                1015                1020                


Asp Thr Leu Thr Asn Ile Asn Asn Gln Ser Phe Asn Asn Phe Met Leu 
1025                1030                1035                1040


Arg Ile Gly Met Asn Lys Gly Gly Val Leu Ala Gly Val Ile Gly Ala 
                1045                1050                1055    


Arg Lys Pro His Tyr Asp Ile Trp Gly Asn Thr Val Asn Val Ala Ser 
            1060                1065                1070        


Arg Met Glu Ser Thr Gly Val Met Gly Asn Ile Gln Val Val Glu Glu 
        1075                1080                1085            


Thr Gln Val Ile Leu Arg Glu Tyr Gly Phe Arg Phe Val Arg Arg Gly 
    1090                1095                1100                


Pro Ile Phe Val Lys Gly Lys Gly Glu Leu Leu Thr Phe Phe Leu Lys 
1105                1110                1115                1120


Gly Arg Asp Lys Leu Ala Thr Phe Pro Asn Gly Pro Ser Val Thr Leu 
                1125                1130                1135    


Pro His Gln Val Val Asp Asn Ser 
            1140                


<210>  22

<211>  247
<212>  PRT
<213>  homo sapiens

<220>
<223>  BDNF

<400>  22
Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  23

<211>  950
<212>  PRT
<213>  homo sapiens

<220>
<223>  KSR2

<400>  23
Met Asp Glu Glu Asn Met Thr Lys Ser Glu Glu Gln Gln Pro Leu Ser 
1               5                   10                  15      


Leu Gln Lys Ala Leu Gln Gln Cys Glu Leu Val Gln Asn Met Ile Asp 
            20                  25                  30          


Leu Ser Ile Ser Asn Leu Glu Gly Leu Arg Thr Lys Cys Ala Thr Ser 
        35                  40                  45              


Asn Asp Leu Thr Gln Lys Glu Ile Arg Thr Leu Glu Ser Lys Leu Val 
    50                  55                  60                  


Lys Tyr Phe Ser Arg Gln Leu Ser Cys Lys Lys Lys Val Ala Leu Gln 
65                  70                  75                  80  


Glu Arg Asn Ala Glu Leu Asp Gly Phe Pro Gln Leu Arg His Trp Phe 
                85                  90                  95      


Arg Ile Val Asp Val Arg Lys Glu Val Leu Glu Glu Ile Ser Pro Gly 
            100                 105                 110         


Gln Leu Ser Leu Glu Asp Leu Leu Glu Met Thr Asp Glu Gln Val Cys 
        115                 120                 125             


Glu Thr Val Glu Lys Tyr Gly Ala Asn Arg Glu Glu Cys Ala Arg Leu 
    130                 135                 140                 


Asn Ala Ser Leu Ser Cys Leu Arg Asn Val His Met Ser Gly Gly Asn 
145                 150                 155                 160 


Leu Ser Lys Gln Asp Trp Thr Ile Gln Trp Pro Thr Thr Glu Thr Gly 
                165                 170                 175     


Lys Glu Asn Asn Pro Val Cys Pro Pro Glu Pro Thr Pro Trp Ile Arg 
            180                 185                 190         


Thr His Leu Ser Gln Ser Pro Arg Val Pro Ser Lys Cys Val Gln His 
        195                 200                 205             


Tyr Cys His Thr Ser Pro Thr Pro Gly Ala Pro Val Tyr Thr His Val 
    210                 215                 220                 


Asp Arg Leu Thr Val Asp Ala Tyr Pro Gly Leu Cys Pro Pro Pro Pro 
225                 230                 235                 240 


Leu Glu Ser Gly His Arg Ser Leu Pro Pro Ser Pro Arg Gln Arg His 
                245                 250                 255     


Ala Val Arg Thr Pro Pro Arg Thr Pro Asn Ile Val Thr Thr Val Thr 
            260                 265                 270         


Pro Pro Gly Thr Pro Pro Met Arg Lys Lys Asn Lys Leu Lys Pro Pro 
        275                 280                 285             


Gly Thr Pro Pro Pro Ser Ser Arg Lys Leu Ile His Leu Ile Pro Gly 
    290                 295                 300                 


Phe Thr Ala Leu His Arg Ser Lys Ser His Glu Phe Gln Leu Gly His 
305                 310                 315                 320 


Arg Val Asp Glu Ala His Thr Pro Lys Ala Lys Lys Lys Ser Lys Pro 
                325                 330                 335     


Leu Asn Leu Lys Ile His Ser Ser Val Gly Ser Cys Glu Asn Ile Pro 
            340                 345                 350         


Ser Gln Gln Arg Ser Pro Leu Leu Ser Glu Arg Ser Leu Arg Ser Phe 
        355                 360                 365             


Phe Val Gly His Ala Pro Phe Leu Pro Ser Thr Pro Pro Val His Thr 
    370                 375                 380                 


Glu Ala Asn Phe Ser Ala Asn Thr Leu Ser Val Pro Arg Trp Ser Pro 
385                 390                 395                 400 


Gln Ile Pro Arg Arg Asp Leu Gly Asn Ser Ile Lys His Arg Phe Ser 
                405                 410                 415     


Thr Lys Tyr Trp Met Ser Gln Thr Cys Thr Val Cys Gly Lys Gly Met 
            420                 425                 430         


Leu Phe Gly Leu Lys Cys Lys Asn Cys Lys Leu Lys Cys His Asn Lys 
        435                 440                 445             


Cys Thr Lys Glu Ala Pro Pro Cys His Leu Leu Ile Ile His Arg Gly 
    450                 455                 460                 


Asp Pro Ala Arg Leu Val Arg Thr Glu Ser Val Pro Cys Asp Ile Asn 
465                 470                 475                 480 


Asn Pro Leu Arg Lys Pro Pro Arg Tyr Ser Asp Leu His Ile Ser Gln 
                485                 490                 495     


Thr Leu Pro Lys Thr Asn Lys Ile Asn Lys Asp His Ile Pro Val Pro 
            500                 505                 510         


Tyr Gln Pro Asp Ser Ser Ser Asn Pro Ser Ser Thr Thr Ser Ser Thr 
        515                 520                 525             


Pro Ser Ser Pro Ala Pro Pro Leu Pro Pro Ser Ala Thr Pro Pro Ser 
    530                 535                 540                 


Pro Leu His Pro Ser Pro Gln Cys Thr Arg Gln Gln Lys Asn Phe Asn 
545                 550                 555                 560 


Leu Pro Ala Ser His Tyr Tyr Lys Tyr Lys Gln Gln Phe Ile Phe Pro 
                565                 570                 575     


Asp Val Val Pro Val Pro Glu Thr Pro Thr Arg Ala Pro Gln Val Ile 
            580                 585                 590         


Leu His Pro Val Thr Ser Asn Pro Ile Leu Glu Gly Asn Pro Leu Leu 
        595                 600                 605             


Gln Ile Glu Val Glu Pro Thr Ser Glu Asn Glu Glu Val His Asp Glu 
    610                 615                 620                 


Ala Glu Glu Ser Glu Asp Asp Phe Glu Glu Met Asn Leu Ser Leu Leu 
625                 630                 635                 640 


Ser Ala Arg Ser Phe Pro Arg Lys Ala Ser Gln Thr Ser Ile Phe Leu 
                645                 650                 655     


Gln Glu Trp Asp Ile Pro Phe Glu Gln Leu Glu Ile Gly Glu Leu Ile 
            660                 665                 670         


Gly Lys Gly Arg Phe Gly Gln Val Tyr His Gly Arg Trp His Gly Glu 
        675                 680                 685             


Val Ala Ile Arg Leu Ile Asp Ile Glu Arg Asp Asn Glu Asp Gln Leu 
    690                 695                 700                 


Lys Ala Phe Lys Arg Glu Val Met Ala Tyr Arg Gln Thr Arg His Glu 
705                 710                 715                 720 


Asn Val Val Leu Phe Met Gly Ala Cys Met Ser Pro Pro His Leu Ala 
                725                 730                 735     


Ile Ile Thr Ser Leu Cys Lys Gly Arg Thr Leu Tyr Ser Val Val Arg 
            740                 745                 750         


Asp Ala Lys Ile Val Leu Asp Val Asn Lys Thr Arg Gln Ile Ala Gln 
        755                 760                 765             


Glu Ile Val Lys Gly Met Gly Tyr Leu His Ala Lys Gly Ile Leu His 
    770                 775                 780                 


Lys Asp Leu Lys Ser Lys Asn Val Phe Tyr Asp Asn Gly Lys Val Val 
785                 790                 795                 800 


Ile Thr Asp Phe Gly Leu Phe Ser Ile Ser Gly Val Leu Gln Ala Gly 
                805                 810                 815     


Arg Arg Glu Asp Lys Leu Arg Ile Gln Asn Gly Trp Leu Cys His Leu 
            820                 825                 830         


Ala Pro Glu Ile Ile Arg Gln Leu Ser Pro Asp Thr Glu Glu Asp Lys 
        835                 840                 845             


Leu Pro Phe Ser Lys His Ser Asp Val Phe Ala Leu Gly Thr Ile Trp 
    850                 855                 860                 


Tyr Glu Leu His Ala Arg Glu Trp Pro Phe Lys Thr Gln Pro Ala Glu 
865                 870                 875                 880 


Ala Ile Ile Trp Gln Met Gly Thr Gly Met Lys Pro Asn Leu Ser Gln 
                885                 890                 895     


Ile Gly Met Gly Lys Glu Ile Ser Asp Ile Leu Leu Phe Cys Trp Ala 
            900                 905                 910         


Phe Glu Gln Glu Glu Arg Pro Thr Phe Thr Lys Leu Met Asp Met Leu 
        915                 920                 925             


Glu Lys Leu Pro Lys Arg Asn Arg Arg Leu Ser His Pro Gly His Phe 
    930                 935                 940                 


Trp Lys Ser Ala Glu Leu 
945                 950 


<210>  24

<211>  167
<212>  PRT
<213>  homo sapiens

<220>
<223>  LEP

<400>  24
Met His Trp Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu 
1               5                   10                  15      


Phe Tyr Val Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys 
            20                  25                  30          


Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr 
        35                  40                  45              


Gln Ser Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro 
    50                  55                  60                  


Gly Leu His Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala 
65                  70                  75                  80  


Val Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln 
                85                  90                  95      


Ile Ser Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala 
            100                 105                 110         


Phe Ser Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu 
        115                 120                 125             


Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val 
    130                 135                 140                 


Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln 
145                 150                 155                 160 


Leu Asp Leu Ser Pro Gly Cys 
                165         


<210>  25

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  TRAC TALEN target

<400>  25
ttcctcctac tcaccatcag cctcctggtt atggtacagg taagagcaa                 49


<210>  26

<211>  47
<212>  DNA
<213>  artificial

<220>
<223>  B2M TALEN target

<400>  26
tccgtggcct tagctgtgct cgcgctactc tctctttctg gcctgga                   47


<210>  27

<211>  2282
<212>  DNA
<213>  artificial

<220>
<223>  HLA-E  AAV insert

<400>  27
caccccagat cggagggcgc cgatgtacag acagcaaact cacccagtct agtgcatgcc     60
ttcttaaaca tcacgagact ctaagaaaag gaaactgaaa acgggaaagt ccctctctct    120
aacctggcac tgcgtcgctg gcttggagac aggtgacggt ccctgcgggc cttgtcctga    180
ttggctgggc acgcgtttaa tataagtgga ggcgtcgcgc tggcgggcat tcctgaagct    240
gacagcattc gggccgagat gtctcgctcc gtggccttag ctgtgctcgc gctactctct    300
cttagcggcc tcgaagctgt tatggctccg cggactttaa ttttaggtgg tggcggatcc    360
ggtggtggcg gttctggtgg tggcggctcc atccagcgta cgcccaaaat tcaagtctac    420
agccgacatc ctgcagagaa cggcaaatct aatttcctga actgctatgt atcaggcttt    480
caccctagcg atatagaagt ggacctgctg aaaaacggag agaggataga aaaggtcgaa    540
cacagcgacc tctccttttc caaggactgg agcttttatc ttctgtatta tactgaattt    600
acacccacgg aaaaagatga gtatgcgtgc cgagtaaacc acgtcacgct gtcacagccc    660
aaaatagtaa aatgggatcg cgacatgggt ggtggcggtt ctggtggtgg cggtagtggc    720
ggcggaggaa gcggtggtgg cggttccgga tctcactcct tgaagtattt ccacacttcc    780
gtgtcccggc ccggccgcgg ggagccccgc ttcatctctg tgggctacgt ggacgacacc    840
cagttcgtgc gcttcgacaa cgacgccgcg agtccgagga tggtgccgcg ggcgccgtgg    900
atggagcagg aggggtcaga gtattgggac cgggagacac ggagcgccag ggacaccgca    960
cagattttcc gagtgaacct gcggacgctg cgcggctact acaatcagag cgaggccggg   1020
tctcacaccc tgcagtggat gcatggctgc gagctggggc ccgacaggcg cttcctccgc   1080
gggtatgaac agttcgccta cgacggcaag gattatctca ccctgaatga ggacctgcgc   1140
tcctggaccg cggtggacac ggcggctcag atctccgagc aaaagtcaaa tgatgcctct   1200
gaggcggagc accagagagc ctacctggaa gacacatgcg tggagtggct ccacaaatac   1260
ctggagaagg ggaaggagac gctgcttcac ctggagcccc caaagacaca cgtgactcac   1320
caccccatct ctgaccatga ggccaccctg aggtgctggg ctctgggctt ctaccctgcg   1380
gagatcacac tgacctggca gcaggatggg gagggccata cccaggacac ggagctcgtg   1440
gagaccaggc ctgcagggga tggaaccttc cagaagtggg cagctgtggt ggtgccttct   1500
ggagaggagc agagatacac gtgccatgtg cagcatgagg ggctacccga gcccgtcacc   1560
ctgagatgga agccggcttc ccagcccacc atccccatcg tgggcatcat tgctggcctg   1620
gttctccttg gatctgtggt ctctggagct gtggttgctg ctgtgatatg gaggaagaag   1680
agctcaggtg gaaaaggagg gagctactat aaggctgagt ggagcgacag tgcccagggg   1740
tctgagtctc acagcttgta actgtgcctt ctagttgcca gccatctgtt gtttgcccct   1800
cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg   1860
aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc   1920
aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat gcggtgggct   1980
ctatgtctct ttctggcctg gaggctatcc agcgtgagtc tctcctaccc tcccgctctg   2040
gtccttcctc tcccgctctg caccctctgt ggccctcgct gtgctctctc gctccgtgac   2100
ttcccttctc caagttctcc ttggtggccc gccgtggggc tagtccaggg ctggatctcg   2160
gggaagcggc ggggtggcct gggagtgggg aagggggtgc gcacccggga cgcgcgctac   2220
ttgccccttt cggcggggag caggggagac ctttggccta cggcgacggg agggtcggga   2280
ca                                                                  2282


<210>  28

<211>  2572
<212>  DNA
<213>  artificial

<220>
<223>  Mesothelin CAR AAV insert

<400>  28
gataagtagc cctgcatttc aggtttcctt gagtggcagg ccaggcctgg ccgtgaacgt     60
tcactgaaat catggcctct tggccaagat tgatagcttg tgcctgtccc tgagtcccag    120
tccatcacga gcagctggtt tctaagatgc tatttcccgt ataaagcatg agaccgtgac    180
ttgccagccc cacagagccc cgcccttgtc catcactggc atctggactc cagcctgggt    240
tggggcaaag agggaaatga gatcatgtcc taaccctgat cctcttgtcc cacagatatc    300
cagggcagcg gcgtgaagca gaccctgaac ttcgacctgc tgaagctggc aggcgatgtg    360
gagtccaatc caggacctat ggctctgccc gtcaccgctc tgctgctgcc actggccctg    420
ctgctgcacg cagcaaggcc acaggtgcag ctgcagcagc ctggcgcaga gctggtgaag    480
cctggcgcca gcatgaagct gtcctgcaag gcctctggct acacattcac ctcctattgg    540
atgcactggg tgaagcagcg cccaggccag ggactggagt ggatcggcat gatccacccc    600
aactctgaca ataccatcta ctatgagaag tttaagagca aggccacact gaccgtggat    660
aagagctcct ctacagccta catgcagctg agctccctga cctccgagga ctctgccgtg    720
tactattgcg ccatcatcat cacacccgtg gtgcctaagt tcgattattg gggccagggc    780
accacactga ccgtgtctag cggaggagga ggaagcggag gaggagaatc cggcggcggc    840
ggctctgaca tcgtgatgac acagagccac cagtttatga gcacctccgt gggcgaccgg    900
gtgagcgtga cctgtaaggc ctcccacgat gtgggcacct ctgtggcctg gtaccagcag    960
aagccaggcc agagccccaa gctgctgatc tattgggcct ccacaaggca caccggagtg   1020
ccagaccgct tcacaggatc tggaagcggc accgacttca ccctgaccat cagcaacgtg   1080
cagtccgagg acctggccga ttacttctgt cagcagtact cctcttatcc tctgacattt   1140
ggcgcaggaa ccaagctgga gctgaagagg gcctctgatc caggctccgg cggaggagaa   1200
tcctgccctt acagcaaccc atccctgtgc tctggaggag gaggatcttg tccctatagc   1260
aatcctagcc tgtgctccgg cggaggaggc agcaccacaa ccccagcacc aaggccacct   1320
acacctgcac caaccatcgc atcccagcca ctgtctctga ggccagaggc atgcagacct   1380
gcagcaggcg gcgccgtgca caccagaggc ctggacttcg cctgcgatat ctacatctgg   1440
gcacctctgg caggaacatg tggcgtgctg ctgctgtccc tggtcatcac cctgtattgt   1500
aagcgaggcc ggaagaaact gctgtatatt ttcaaacagc cctttatgag acctgtgcag   1560
actacccagg aggaagacgg ctgcagctgt aggttccccg aggaagagga aggcgggtgt   1620
gagctgaggg tcaagtttag ccgctccgca gatgcccctg cttaccagca ggggcagaat   1680
cagctgtata acgagctgaa tctgggacgg agagaggaat acgacgtgct ggataaaagg   1740
cgcgggagag accccgaaat gggaggcaag ccacgacgga aaaaccccca ggagggcctg   1800
tacaatgaac tgcagaagga caaaatggca gaggcctata gtgaaatcgg gatgaaggga   1860
gagagaaggc gcggcaaagg gcacgatggc ctgtaccagg ggctgtctac tgccaccaag   1920
gacacctatg atgctctgca tatgcaggca ctgcctccaa ggtgataatc tagagggccc   1980
gtttaaaccc gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc   2040
ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa   2100
aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg   2160
gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg   2220
ggctctatga ctagtggcga attcccgtgt accagctgag agactctaaa tccagtgaca   2280
agtctgtctg cctattcacc gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt   2340
ctgatgtgta tatcacagac aaaactgtgc tagacatgag gtctatggac ttcaagagca   2400
acagtgctgt ggcctggagc aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca   2460
gcattattcc agaagacacc ttcttcccca gcccaggtaa gggcagcttt ggtgccttcg   2520
caggctgttt ccttgcttca ggaaatcgga tcccccaggt agataagtag ca           2572


<210>  29

<211>  224
<212>  DNA
<213>  artificial

<220>
<223>  BGH poly A sequence

<400>  29
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc     60
tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc    120
tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt    180
gggaagacaa tagcaggcat gctggggatg cggtgggctc tatg                     224


<210>  30

<211>  301
<212>  DNA
<213>  artificial

<220>
<223>  B2M Left homology arm

<400>  30
cgcgcacccc agatcggagg gcgccgatgt acagacagca aactcaccca gtctagtgca     60
tgccttctta aacatcacga gactctaaga aaaggaaact gaaaacggga aagtccctct    120
ctctaacctg gcactgcgtc gctggcttgg agacaggtga cggtccctgc gggccttgtc    180
ctgattggct gggcacgcgt ttaatataag tggaggcgtc gcgctggcgg gcattcctga    240
agctgacagc attcgggccg agatgtctcg ctccgtggcc ttagctgtgc tcgcgctact    300
c                                                                    301


<210>  31

<211>  300
<212>  DNA
<213>  artificial

<220>
<223>  B2M Right homology arm

<400>  31
tctctttctg gcctggaggc tatccagcgt gagtctctcc taccctcccg ctctggtcct     60
tcctctcccg ctctgcaccc tctgtggccc tcgctgtgct ctctcgctcc gtgacttccc    120
ttctccaagt tctccttggt ggcccgccgt ggggctagtc cagggctgga tctcggggaa    180
gcggcggggt ggcctgggag tggggaaggg ggtgcgcacc cgggacgcgc gctacttgcc    240
cctttcggcg gggagcaggg gagacctttg gcctacggcg acgggagggt cgggacaaag    300


<210>  32

<211>  2781
<212>  DNA
<213>  artificial

<220>
<223>  TRAC TALEN left Nucl. Seq

<400>  32
atgggcgatc ctaaaaagaa acgtaaggtc atcgatatcg ccgatctacg cacgctcggc     60
tacagccagc agcaacagga gaagatcaaa ccgaaggttc gttcgacagt ggcgcagcac    120
cacgaggcac tggtcggcca cgggtttaca cacgcgcaca tcgttgcgtt aagccaacac    180
ccggcagcgt tagggaccgt cgctgtcaag tatcaggaca tgatcgcagc gttgccagag    240
gcgacacacg aagcgatcgt tggcgtcggc aaacagtggt ccggcgcacg cgctctggag    300
gccttgctca cggtggcggg agagttgaga ggtccaccgt tacagttgga cacaggccaa    360
cttctcaaga ttgcaaaacg tggcggcgtg accgcagtgg aggcagtgca tgcatggcgc    420
aatgcactga cgggtgcccc gctcaacttg accccccagc aggtggtggc catcgccagc    480
aatggcggtg gcaagcaggc gctggagacg gtccagcggc tgttgccggt gctgtgccag    540
gcccacggct tgacccccca gcaggtggtg gccatcgcca gcaataatgg tggcaagcag    600
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccc    660
cagcaggtgg tggccatcgc cagcaatggc ggtggcaagc aggcgctgga gacggtccag    720
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cggagcaggt ggtggccatc    780
gccagccacg atggcggcaa gcaggcgctg gagacggtcc agcggctgtt gccggtgctg    840
tgccaggccc acggcttgac cccggagcag gtggtggcca tcgccagcca cgatggcggc    900
aagcaggcgc tggagacggt ccagcggctg ttgccggtgc tgtgccaggc ccacggcttg    960
accccggagc aggtggtggc catcgccagc cacgatggcg gcaagcaggc gctggagacg   1020
gtccagcggc tgttgccggt gctgtgccag gcccacggct tgaccccgga gcaggtggtg   1080
gccatcgcca gcaatattgg tggcaagcag gcgctggaga cggtgcaggc gctgttgccg   1140
gtgctgtgcc aggcccacgg cttgaccccg gagcaggtgg tggccatcgc cagccacgat   1200
ggcggcaagc aggcgctgga gacggtccag cggctgttgc cggtgctgtg ccaggcccac   1260
ggcttgaccc cggagcaggt ggtggccatc gccagcaata ttggtggcaa gcaggcgctg   1320
gagacggtgc aggcgctgtt gccggtgctg tgccaggccc acggcttgac cccccagcag   1380
gtggtggcca tcgccagcaa taatggtggc aagcaggcgc tggagacggt ccagcggctg   1440
ttgccggtgc tgtgccaggc ccacggcttg accccggagc aggtggtggc catcgccagc   1500
aatattggtg gcaagcaggc gctggagacg gtgcaggcgc tgttgccggt gctgtgccag   1560
gcccacggct tgacccccca gcaggtggtg gccatcgcca gcaatggcgg tggcaagcag   1620
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccg   1680
gagcaggtgg tggccatcgc cagcaatatt ggtggcaagc aggcgctgga gacggtgcag   1740
gcgctgttgc cggtgctgtg ccaggcccac ggcttgaccc cccagcaggt ggtggccatc   1800
gccagcaatg gcggtggcaa gcaggcgctg gagacggtcc agcggctgtt gccggtgctg   1860
tgccaggccc acggcttgac cccggagcag gtggtggcca tcgccagcca cgatggcggc   1920
aagcaggcgc tggagacggt ccagcggctg ttgccggtgc tgtgccaggc ccacggcttg   1980
acccctcagc aggtggtggc catcgccagc aatggcggcg gcaggccggc gctggagagc   2040
attgttgccc agttatctcg ccctgatccg gcgttggccg cgttgaccaa cgaccacctc   2100
gtcgccttgg cctgcctcgg cgggcgtcct gcgctggatg cagtgaaaaa gggattgggg   2160
gatcctatca gccgttccca gctggtgaag tccgagctgg aggagaagaa atccgagttg   2220
aggcacaagc tgaagtacgt gccccacgag tacatcgagc tgatcgagat cgcccggaac   2280
agcacccagg accgtatcct ggagatgaag gtgatggagt tcttcatgaa ggtgtacggc   2340
tacaggggca agcacctggg cggctccagg aagcccgacg gcgccatcta caccgtgggc   2400
tcccccatcg actacggcgt gatcgtggac accaaggcct actccggcgg ctacaacctg   2460
cccatcggcc aggccgacga aatgcagagg tacgtggagg agaaccagac caggaacaag   2520
cacatcaacc ccaacgagtg gtggaaggtg tacccctcca gcgtgaccga gttcaagttc   2580
ctgttcgtgt ccggccactt caagggcaac tacaaggccc agctgaccag gctgaaccac   2640
atcaccaact gcaacggcgc cgtgctgtcc gtggaggagc tcctgatcgg cggcgagatg   2700
atcaaggccg gcaccctgac cctggaggag gtgaggagga agttcaacaa cggcgagatc   2760
aacttcgcgg ccgactgata a                                             2781


<210>  33

<211>  2781
<212>  DNA
<213>  artificial

<220>
<223>  TRAC TALEN right Nucl. Seq

<400>  33
atgggcgatc ctaaaaagaa acgtaaggtc atcgatatcg ccgatctacg cacgctcggc     60
tacagccagc agcaacagga gaagatcaaa ccgaaggttc gttcgacagt ggcgcagcac    120
cacgaggcac tggtcggcca cgggtttaca cacgcgcaca tcgttgcgtt aagccaacac    180
ccggcagcgt tagggaccgt cgctgtcaag tatcaggaca tgatcgcagc gttgccagag    240
gcgacacacg aagcgatcgt tggcgtcggc aaacagtggt ccggcgcacg cgctctggag    300
gccttgctca cggtggcggg agagttgaga ggtccaccgt tacagttgga cacaggccaa    360
cttctcaaga ttgcaaaacg tggcggcgtg accgcagtgg aggcagtgca tgcatggcgc    420
aatgcactga cgggtgcccc gctcaacttg accccggagc aggtggtggc catcgccagc    480
cacgatggcg gcaagcaggc gctggagacg gtccagcggc tgttgccggt gctgtgccag    540
gcccacggct tgacccccca gcaggtggtg gccatcgcca gcaatggcgg tggcaagcag    600
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccg    660
gagcaggtgg tggccatcgc cagccacgat ggcggcaagc aggcgctgga gacggtccag    720
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cggagcaggt ggtggccatc    780
gccagcaata ttggtggcaa gcaggcgctg gagacggtgc aggcgctgtt gccggtgctg    840
tgccaggccc acggcttgac cccccagcag gtggtggcca tcgccagcaa taatggtggc    900
aagcaggcgc tggagacggt ccagcggctg ttgccggtgc tgtgccaggc ccacggcttg    960
accccggagc aggtggtggc catcgccagc cacgatggcg gcaagcaggc gctggagacg   1020
gtccagcggc tgttgccggt gctgtgccag gcccacggct tgacccccca gcaggtggtg   1080
gccatcgcca gcaatggcgg tggcaagcag gcgctggaga cggtccagcg gctgttgccg   1140
gtgctgtgcc aggcccacgg cttgaccccc cagcaggtgg tggccatcgc cagcaataat   1200
ggtggcaagc aggcgctgga gacggtccag cggctgttgc cggtgctgtg ccaggcccac   1260
ggcttgaccc cccagcaggt ggtggccatc gccagcaata atggtggcaa gcaggcgctg   1320
gagacggtcc agcggctgtt gccggtgctg tgccaggccc acggcttgac cccccagcag   1380
gtggtggcca tcgccagcaa tggcggtggc aagcaggcgc tggagacggt ccagcggctg   1440
ttgccggtgc tgtgccaggc ccacggcttg accccggagc aggtggtggc catcgccagc   1500
aatattggtg gcaagcaggc gctggagacg gtgcaggcgc tgttgccggt gctgtgccag   1560
gcccacggct tgaccccgga gcaggtggtg gccatcgcca gccacgatgg cggcaagcag   1620
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccg   1680
gagcaggtgg tggccatcgc cagcaatatt ggtggcaagc aggcgctgga gacggtgcag   1740
gcgctgttgc cggtgctgtg ccaggcccac ggcttgaccc cggagcaggt ggtggccatc   1800
gccagccacg atggcggcaa gcaggcgctg gagacggtcc agcggctgtt gccggtgctg   1860
tgccaggccc acggcttgac cccccagcag gtggtggcca tcgccagcaa taatggtggc   1920
aagcaggcgc tggagacggt ccagcggctg ttgccggtgc tgtgccaggc ccacggcttg   1980
acccctcagc aggtggtggc catcgccagc aatggcggcg gcaggccggc gctggagagc   2040
attgttgccc agttatctcg ccctgatccg gcgttggccg cgttgaccaa cgaccacctc   2100
gtcgccttgg cctgcctcgg cgggcgtcct gcgctggatg cagtgaaaaa gggattgggg   2160
gatcctatca gccgttccca gctggtgaag tccgagctgg aggagaagaa atccgagttg   2220
aggcacaagc tgaagtacgt gccccacgag tacatcgagc tgatcgagat cgcccggaac   2280
agcacccagg accgtatcct ggagatgaag gtgatggagt tcttcatgaa ggtgtacggc   2340
tacaggggca agcacctggg cggctccagg aagcccgacg gcgccatcta caccgtgggc   2400
tcccccatcg actacggcgt gatcgtggac accaaggcct actccggcgg ctacaacctg   2460
cccatcggcc aggccgacga aatgcagagg tacgtggagg agaaccagac caggaacaag   2520
cacatcaacc ccaacgagtg gtggaaggtg tacccctcca gcgtgaccga gttcaagttc   2580
ctgttcgtgt ccggccactt caagggcaac tacaaggccc agctgaccag gctgaaccac   2640
atcaccaact gcaacggcgc cgtgctgtcc gtggaggagc tcctgatcgg cggcgagatg   2700
atcaaggccg gcaccctgac cctggaggag gtgaggagga agttcaacaa cggcgagatc   2760
aacttcgcgg ccgactgata a                                             2781


<210>  34

<211>  2781
<212>  DNA
<213>  artificial

<220>
<223>  B2M TALEN left Nucl. Seq

<400>  34
atgggcgatc ctaaaaagaa acgtaaggtc atcgatatcg ccgatctacg cacgctcggc     60
tacagccagc agcaacagga gaagatcaaa ccgaaggttc gttcgacagt ggcgcagcac    120
cacgaggcac tggtcggcca cgggtttaca cacgcgcaca tcgttgcgtt aagccaacac    180
ccggcagcgt tagggaccgt cgctgtcaag tatcaggaca tgatcgcagc gttgccagag    240
gcgacacacg aagcgatcgt tggcgtcggc aaacagtggt ccggcgcacg cgctctggag    300
gccttgctca cggtggcggg agagttgaga ggtccaccgt tacagttgga cacaggccaa    360
cttctcaaga ttgcaaaacg tggcggcgtg accgcagtgg aggcagtgca tgcatggcgc    420
aatgcactga cgggtgcccc gctcaacttg accccggagc aggtggtggc catcgccagc    480
cacgatggcg gcaagcaggc gctggagacg gtccagcggc tgttgccggt gctgtgccag    540
gcccacggct tgaccccgga gcaggtggtg gccatcgcca gccacgatgg cggcaagcag    600
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccc    660
cagcaggtgg tggccatcgc cagcaataat ggtggcaagc aggcgctgga gacggtccag    720
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cccagcaggt ggtggccatc    780
gccagcaatg gcggtggcaa gcaggcgctg gagacggtcc agcggctgtt gccggtgctg    840
tgccaggccc acggcttgac cccccagcag gtggtggcca tcgccagcaa taatggtggc    900
aagcaggcgc tggagacggt ccagcggctg ttgccggtgc tgtgccaggc ccacggcttg    960
accccccagc aggtggtggc catcgccagc aataatggtg gcaagcaggc gctggagacg   1020
gtccagcggc tgttgccggt gctgtgccag gcccacggct tgaccccgga gcaggtggtg   1080
gccatcgcca gccacgatgg cggcaagcag gcgctggaga cggtccagcg gctgttgccg   1140
gtgctgtgcc aggcccacgg cttgaccccg gagcaggtgg tggccatcgc cagccacgat   1200
ggcggcaagc aggcgctgga gacggtccag cggctgttgc cggtgctgtg ccaggcccac   1260
ggcttgaccc cccagcaggt ggtggccatc gccagcaatg gcggtggcaa gcaggcgctg   1320
gagacggtcc agcggctgtt gccggtgctg tgccaggccc acggcttgac cccccagcag   1380
gtggtggcca tcgccagcaa tggcggtggc aagcaggcgc tggagacggt ccagcggctg   1440
ttgccggtgc tgtgccaggc ccacggcttg accccggagc aggtggtggc catcgccagc   1500
aatattggtg gcaagcaggc gctggagacg gtgcaggcgc tgttgccggt gctgtgccag   1560
gcccacggct tgacccccca gcaggtggtg gccatcgcca gcaataatgg tggcaagcag   1620
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccg   1680
gagcaggtgg tggccatcgc cagccacgat ggcggcaagc aggcgctgga gacggtccag   1740
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cccagcaggt ggtggccatc   1800
gccagcaatg gcggtggcaa gcaggcgctg gagacggtcc agcggctgtt gccggtgctg   1860
tgccaggccc acggcttgac cccccagcag gtggtggcca tcgccagcaa taatggtggc   1920
aagcaggcgc tggagacggt ccagcggctg ttgccggtgc tgtgccaggc ccacggcttg   1980
acccctcagc aggtggtggc catcgccagc aatggcggcg gcaggccggc gctggagagc   2040
attgttgccc agttatctcg ccctgatccg gcgttggccg cgttgaccaa cgaccacctc   2100
gtcgccttgg cctgcctcgg cgggcgtcct gcgctggatg cagtgaaaaa gggattgggg   2160
gatcctatca gccgttccca gctggtgaag tccgagctgg aggagaagaa atccgagttg   2220
aggcacaagc tgaagtacgt gccccacgag tacatcgagc tgatcgagat cgcccggaac   2280
agcacccagg accgtatcct ggagatgaag gtgatggagt tcttcatgaa ggtgtacggc   2340
tacaggggca agcacctggg cggctccagg aagcccgacg gcgccatcta caccgtgggc   2400
tcccccatcg actacggcgt gatcgtggac accaaggcct actccggcgg ctacaacctg   2460
cccatcggcc aggccgacga aatgcagagg tacgtggagg agaaccagac caggaacaag   2520
cacatcaacc ccaacgagtg gtggaaggtg tacccctcca gcgtgaccga gttcaagttc   2580
ctgttcgtgt ccggccactt caagggcaac tacaaggccc agctgaccag gctgaaccac   2640
atcaccaact gcaacggcgc cgtgctgtcc gtggaggagc tcctgatcgg cggcgagatg   2700
atcaaggccg gcaccctgac cctggaggag gtgaggagga agttcaacaa cggcgagatc   2760
aacttcgcgg ccgactgata a                                             2781


<210>  35

<211>  2781
<212>  DNA
<213>  artificial

<220>
<223>  B2M TALEN right Nucl. Seq

<400>  35
atgggcgatc ctaaaaagaa acgtaaggtc atcgatatcg ccgatctacg cacgctcggc     60
tacagccagc agcaacagga gaagatcaaa ccgaaggttc gttcgacagt ggcgcagcac    120
cacgaggcac tggtcggcca cgggtttaca cacgcgcaca tcgttgcgtt aagccaacac    180
ccggcagcgt tagggaccgt cgctgtcaag tatcaggaca tgatcgcagc gttgccagag    240
gcgacacacg aagcgatcgt tggcgtcggc aaacagtggt ccggcgcacg cgctctggag    300
gccttgctca cggtggcggg agagttgaga ggtccaccgt tacagttgga cacaggccaa    360
cttctcaaga ttgcaaaacg tggcggcgtg accgcagtgg aggcagtgca tgcatggcgc    420
aatgcactga cgggtgcccc gctcaacttg accccggagc aggtggtggc catcgccagc    480
cacgatggcg gcaagcaggc gctggagacg gtccagcggc tgttgccggt gctgtgccag    540
gcccacggct tgaccccgga gcaggtggtg gccatcgcca gccacgatgg cggcaagcag    600
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccg    660
gagcaggtgg tggccatcgc cagcaatatt ggtggcaagc aggcgctgga gacggtgcag    720
gcgctgttgc cggtgctgtg ccaggcccac ggcttgaccc cccagcaggt ggtggccatc    780
gccagcaata atggtggcaa gcaggcgctg gagacggtcc agcggctgtt gccggtgctg    840
tgccaggccc acggcttgac cccccagcag gtggtggcca tcgccagcaa taatggtggc    900
aagcaggcgc tggagacggt ccagcggctg ttgccggtgc tgtgccaggc ccacggcttg    960
accccggagc aggtggtggc catcgccagc cacgatggcg gcaagcaggc gctggagacg   1020
gtccagcggc tgttgccggt gctgtgccag gcccacggct tgaccccgga gcaggtggtg   1080
gccatcgcca gccacgatgg cggcaagcag gcgctggaga cggtccagcg gctgttgccg   1140
gtgctgtgcc aggcccacgg cttgaccccg gagcaggtgg tggccatcgc cagcaatatt   1200
ggtggcaagc aggcgctgga gacggtgcag gcgctgttgc cggtgctgtg ccaggcccac   1260
ggcttgaccc cccagcaggt ggtggccatc gccagcaata atggtggcaa gcaggcgctg   1320
gagacggtcc agcggctgtt gccggtgctg tgccaggccc acggcttgac cccggagcag   1380
gtggtggcca tcgccagcaa tattggtggc aagcaggcgc tggagacggt gcaggcgctg   1440
ttgccggtgc tgtgccaggc ccacggcttg accccggagc aggtggtggc catcgccagc   1500
aatattggtg gcaagcaggc gctggagacg gtgcaggcgc tgttgccggt gctgtgccag   1560
gcccacggct tgaccccgga gcaggtggtg gccatcgcca gcaatattgg tggcaagcag   1620
gcgctggaga cggtgcaggc gctgttgccg gtgctgtgcc aggcccacgg cttgaccccc   1680
cagcaggtgg tggccatcgc cagcaataat ggtggcaagc aggcgctgga gacggtccag   1740
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cggagcaggt ggtggccatc   1800
gccagcaata ttggtggcaa gcaggcgctg gagacggtgc aggcgctgtt gccggtgctg   1860
tgccaggccc acggcttgac cccccagcag gtggtggcca tcgccagcaa taatggtggc   1920
aagcaggcgc tggagacggt ccagcggctg ttgccggtgc tgtgccaggc ccacggcttg   1980
acccctcagc aggtggtggc catcgccagc aatggcggcg gcaggccggc gctggagagc   2040
attgttgccc agttatctcg ccctgatccg gcgttggccg cgttgaccaa cgaccacctc   2100
gtcgccttgg cctgcctcgg cgggcgtcct gcgctggatg cagtgaaaaa gggattgggg   2160
gatcctatca gccgttccca gctggtgaag tccgagctgg aggagaagaa atccgagttg   2220
aggcacaagc tgaagtacgt gccccacgag tacatcgagc tgatcgagat cgcccggaac   2280
agcacccagg accgtatcct ggagatgaag gtgatggagt tcttcatgaa ggtgtacggc   2340
tacaggggca agcacctggg cggctccagg aagcccgacg gcgccatcta caccgtgggc   2400
tcccccatcg actacggcgt gatcgtggac accaaggcct actccggcgg ctacaacctg   2460
cccatcggcc aggccgacga aatgcagagg tacgtggagg agaaccagac caggaacaag   2520
cacatcaacc ccaacgagtg gtggaaggtg tacccctcca gcgtgaccga gttcaagttc   2580
ctgttcgtgt ccggccactt caagggcaac tacaaggccc agctgaccag gctgaaccac   2640
atcaccaact gcaacggcgc cgtgctgtcc gtggaggagc tcctgatcgg cggcgagatg   2700
atcaaggccg gcaccctgac cctggaggag gtgaggagga agttcaacaa cggcgagatc   2760
aacttcgcgg ccgactgata a                                             2781


<210>  36

<211>  925
<212>  PRT
<213>  artificial

<220>
<223>  TRAC TALEN left Protein. Seq

<400>  36
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 


<210>  37

<211>  925
<212>  PRT
<213>  artificial

<220>
<223>  TRAC TALEN right Prot. Seq

<400>  37
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 


<210>  38

<211>  925
<212>  PRT
<213>  artificial

<220>
<223>  B2M TALEN left Prot. Seq

<400>  38
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 


<210>  39

<211>  925
<212>  PRT
<213>  artificial

<220>
<223>  B2M TALEN right Prot. Seq

<400>  39
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 


<210>  40

<211>  74
<212>  PRT
<213>  artificial

<220>
<223>  i53 Prot. Seq

<400>  40
Met Leu Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ala Phe Ala Gly Lys 
        35                  40                  45              


Ser Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Leu Lys Asp 
    50                  55                  60                  


Ser Lys Leu His Pro Leu Leu Arg Leu Arg 
65                  70                  


<210>  41

<211>  233
<212>  PRT
<213>  artificial

<220>
<223>  Bclxl Prot.Seq

<400>  41
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         


His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 


Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 


Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp 
                165                 170                 175     


His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
            180                 185                 190         


Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
        195                 200                 205             


Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
    210                 215                 220                 


Leu Leu Gly Ser Leu Phe Ser Arg Lys 
225                 230             


<210>  42

<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  B2M Signal Seq

<400>  42
Ser Leu Ser Gly Leu Glu Ala 
1               5           


<210>  43

<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  HLA-G peptid

<400>  43
Val Met Ala Pro Arg Thr Leu Ile Leu 
1               5                   


<210>  44

<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  3xG4S linker

<400>  44
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  45

<211>  99
<212>  PRT
<213>  artificial

<220>
<223>  B2M peptide

<400>  45
Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu 
1               5                   10                  15      


Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro 
            20                  25                  30          


Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys 
        35                  40                  45              


Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu 
    50                  55                  60                  


Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  46

<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  4xG4S linker

<400>  46
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  47

<211>  335
<212>  PRT
<213>  artificial

<220>
<223>  HLA-E  full length

<400>  47
His Ser Leu Lys Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg Gly 
1               5                   10                  15      


Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln Phe Val 
            20                  25                  30          


Arg Phe Asp Asn Asp Ala Ala Ser Pro Arg Met Val Pro Arg Ala Pro 
        35                  40                  45              


Trp Met Glu Gln Glu Gly Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser 
    50                  55                  60                  


Ala Arg Asp Thr Ala Gln Ile Phe Arg Val Asn Leu Arg Thr Leu Arg 
65                  70                  75                  80  


Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Trp Met 
                85                  90                  95      


His Gly Cys Glu Leu Gly Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu 
            100                 105                 110         


Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu 
        115                 120                 125             


Arg Ser Trp Thr Ala Val Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys 
    130                 135                 140                 


Ser Asn Asp Ala Ser Glu Ala Glu His Gln Arg Ala Tyr Leu Glu Asp 
145                 150                 155                 160 


Thr Cys Val Glu Trp Leu His Lys Tyr Leu Glu Lys Gly Lys Glu Thr 
                165                 170                 175     


Leu Leu His Leu Glu Pro Pro Lys Thr His Val Thr His His Pro Ile 
            180                 185                 190         


Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro 
        195                 200                 205             


Ala Glu Ile Thr Leu Thr Trp Gln Gln Asp Gly Glu Gly His Thr Gln 
    210                 215                 220                 


Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln 
225                 230                 235                 240 


Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr 
                245                 250                 255     


Cys His Val Gln His Glu Gly Leu Pro Glu Pro Val Thr Leu Arg Trp 
            260                 265                 270         


Lys Pro Ala Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile Ala Gly 
        275                 280                 285             


Leu Val Leu Leu Gly Ser Val Val Ser Gly Ala Val Val Ala Ala Val 
    290                 295                 300                 


Ile Trp Arg Lys Lys Ser Ser Gly Gly Lys Gly Gly Ser Tyr Tyr Lys 
305                 310                 315                 320 


Ala Glu Trp Ser Asp Ser Ala Gln Gly Ser Glu Ser His Ser Leu 
                325                 330                 335 


<210>  48

<211>  225
<212>  DNA
<213>  artificial

<220>
<223>  i53 Nucl. Seq

<400>  48
atgttgattt tcgtgaaaac ccttaccggg aaaaccatca ccctcgaggt tgaaccctcg     60
gatacgatag aaaatgtaaa ggccaagatc caggataagg aaggaattcc tcctgatcag    120
cagagactgg cctttgctgg caaatcgctg gaagatggac gtactttgtc tgactacaat    180
attctaaagg actctaaact tcatcctctg ttgagacttc gttga                    225


<210>  49

<211>  702
<212>  DNA
<213>  artificial

<220>
<223>  Bclxl Nucl.Seq

<400>  49
atgtctcaga gcaaccggga gctggtggtt gactttctct cctacaagct ttcccagaaa     60
ggatacagct ggagtcagtt tagtgatgtg gaagagaaca ggactgaggc cccagaaggg    120
actgaatcgg agatggagac ccccagtgcc atcaatggca acccatcctg gcacctggca    180
gacagccccg cggtgaatgg agccactggc cacagcagca gtttggatgc ccgggaggtg    240
atccccatgg cagcagtaaa gcaagcgctg agggaggcag gcgacgagtt tgaactgcgg    300
taccggcggg cattcagtga cctgacatcc cagctccaca tcaccccagg gacagcatat    360
cagagctttg aacaggtagt gaatgaactc ttccgggatg gggtaaactg gggtcgcatt    420
gtggcctttt tctccttcgg cggggcactg tgcgtggaaa gcgtagacaa ggagatgcag    480
gtattggtga gtcggatcgc agcttggatg gccacttacc tgaatgacca cctagagcct    540
tggatccagg agaacggcgg ctgggatact tttgtggaac tctatgggaa caatgcagca    600
gccgagagcc gaaagggcca ggaacgcttc aaccgctggt tcctgacggg catgactgtg    660
gccggcgtgg ttctgctggg ctcactcttc agtcggaaat ga                       702


























