                         SEQUENCE LISTING

<110>  CENTRE LEON BERARD
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       INSERM (Institut National de la Santé et de la Recherche 
       Médicale)
       UNIVERSITE CLAUDE BERNARD LYON 1
 
<120>  Ribosomal RNAs 2'O-methylation as a novel source of biomarkers 
       relevant for diagnosis, prognosis and therapy of cancers

<130>  B380161PCT D41031

<150>  EP20306461.3
<151>  2020-11-27

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  5070
<212>  DNA
<213>  Homo sapiens

<400>  1
cgcgacctca gatcagacgt ggcgacccgc tgaatttaag catattagtc agcggaggag       60

aagaaactaa ccaggattcc ctcagtaacg gcgagtgaac agggaagagc ccagcgccga      120

atccccgccc cgcggcgggg cgcgggacat gtggcgtacg gaagacccgc tccccggcgc      180

cgctcgtggg gggcccaagt ccttctgatc gaggcccagc ccgtggacgg tgtgaggccg      240

gtagcggccc ccggcgcgcc gggcccgggt cttcccggag tcgggttgct tgggaatgca      300

gcccaaagcg ggtggtaaac tccatctaag gctaaatacc ggcacgagac cgatagtcaa      360

caagtaccgt aagggaaagt tgaaaagaac tttgaagaga gagttcaaga gggcgtgaaa      420

ccgttaagag gtaaacgggt ggggtccgcg cagtccgccc ggaggattca acccggcggc      480

gggtccggcc gtgtcggcgg cccggcggat ctttcccgcc ccccgttcct cccgacccct      540

ccacccgccc tcccttcccc cgccgcccct cctcctcctc cccggagggg gcgggctccg      600

gcgggtgcgg gggtgggcgg gcggggccgg gggtggggtc ggcgggggac cgtcccccga      660

ccggcgaccg gccgccgccg ggcgcatttc caccgcggcg gtgcgccgcg accggctccg      720

ggacggctgg gaaggcccgg cggggaaggt ggctcggggg gccccgtccg tccgtccgtc      780

cgtcctcctc ctcccccgtc tccgcccccc ggccccgcgt cctccctcgg gagggcgcgc      840

gggtcggggc ggcggcggcg gcggcggtgg cggcggcggc ggcggcggcg ggaccgaaac      900

cccccccgag tgttacagcc cccccggcag cagcactcgc cgaatcccgg ggccgaggga      960

gcgagacccg tcgccgcgct ctcccccctc ccggcgccca cccccgcggg gaatcccccg     1020

cgaggggggt ctcccccgcg ggggcgcgcc ggcgtctcct cgtggggggg ccgggccacc     1080

cctcccacgg cgcgaccgct ctcccacccc tcctccccgc gcccccgccc cggcgacggg     1140

gggggtgccg cgcgcgggtc ggggggcggg gcggactgtc cccagtgcgc cccgggcggg     1200

tcgcgccgtc gggcccgggg gaggttctct cggggccacg cgcgcgtccc ccgaagaggg     1260

ggacggcgga gcgagcgcac ggggtcggcg gcgacgtcgg ctacccaccc gacccgtctt     1320

gaaacacgga ccaaggagtc taacacgtgc gcgagtcggg ggctcgcacg aaagccgccg     1380

tggcgcaatg aaggtgaagg ccggcgcgct cgccggccga ggtgggatcc cgaggcctct     1440

ccagtccgcc gagggcgcac caccggcccg tctcgcccgc cgcgccgggg aggtggagca     1500

cgagcgcacg tgttaggacc cgaaagatgg tgaactatgc ctgggcaggg cgaagccaga     1560

ggaaactctg gtggaggtcc gtagcggtcc tgacgtgcaa atcggtcgtc cgacctgggt     1620

ataggggcga aagactaatc gaaccatcta gtagctggtt ccctccgaag tttccctcag     1680

gatagctggc gctctcgcag acccgacgca cccccgccac gcagttttat ccggtaaagc     1740

gaatgattag aggtcttggg gccgaaacga tctcaaccta ttctcaaact ttaaatgggt     1800

aagaagcccg gctcgctggc gtggagccgg gcgtggaatg cgagtgccta gtgggccact     1860

tttggtaagc agaactggcg ctgcgggatg aaccgaacgc cgggttaagg cgcccgatgc     1920

cgacgctcat cagaccccag aaaaggtgtt ggttgatata gacagcagga cggtggccat     1980

ggaagtcgga atccgctaag gagtgtgtaa caactcacct gccgaatcaa ctagccctga     2040

aaatggatgg cgctggagcg tcgggcccat acccggccgt cgccggcagt cgagagtgga     2100

cgggagcggc gggggcggcg cgcgcgcgcg cgcgtgtggt gtgcgtcgga gggcggcggc     2160

ggcggcggcg gcgggggtgt ggggtccttc ccccgccccc ccccccacgc ctcctcccct     2220

cctcccgccc acgccccgct ccccgccccc ggagccccgc ggacgctacg ccgcgacgag     2280

taggagggcc gctgcggtga gccttgaagc ctagggcgcg ggcccgggtg gagccgccgc     2340

aggtgcagat cttggtggta gtagcaaata ttcaaacgag aactttgaag gccgaagtgg     2400

agaagggttc catgtgaaca gcagttgaac atgggtcagt cggtcctgag agatgggcga     2460

gcgccgttcc gaagggacgg gcgatggcct ccgttgccct cggccgatcg aaagggagtc     2520

gggttcagat ccccgaatcc ggagtggcgg agatgggcgc cgcgaggcgt ccagtgcggt     2580

aacgcgaccg atcccggaga agccggcggg agccccgggg agagttctct tttctttgtg     2640

aagggcaggg cgccctggaa tgggttcgcc ccgagagagg ggcccgtgcc ttggaaagcg     2700

tcgcggttcc ggcggcgtcc ggtgagctct cgctggccct tgaaaatccg ggggagaggg     2760

tgtaaatctc gcgccgggcc gtacccatat ccgcagcagg tctccaaggt gaacagcctc     2820

tggcatgttg gaacaatgta ggtaagggaa gtcggcaagc cggatccgta acttcgggat     2880

aaggattggc tctaagggct gggtcggtcg ggctggggcg cgaagcgggg ctgggcgcgc     2940

gccgcggctg gacgaggcgc cgccgccccc cccacgcccg gggcaccccc ctcgcggccc     3000

tcccccgccc caccccgcgc gcgccgctcg ctccctcccc gccccgcgcc ctctctctct     3060

ctctctcccc cgctccccgt cctcccccct ccccggggga gcgccgcgtg ggggcggcgg     3120

cggggggaga agggtcgggg cggcaggggc cggcggcggc ccgccgcggg gccccggcgg     3180

cgggggcacg gtcccccgcg aggggggccc gggcacccgg ggggccggcg gcggcggcga     3240

ctctggacgc gagccgggcc cttcccgtgg atcgccccag ctgcggcggg cgtcgcggcc     3300

gcccccgggg agcccggcgg gcgccggcgc gccccccccc ccaccccacg tctcgtcgcg     3360

cgcgcgtccg ctgggggcgg ggagcggtcg ggcggcggcg gtcggcgggc ggcggggcgg     3420

ggcggttcgt ccccccgccc tacccccccg gccccgtccg ccccccgttc ccccctcctc     3480

ctcggcgcgc ggcggcggcg gcggcaggcg gcggaggggc cgcgggccgg tcccccccgc     3540

cgggtccgcc cccggggccg cggttccgcg cggcgcctcg cctcggccgg cgcctagcag     3600

ccgacttaga actggtgcgg accaggggaa tccgactgtt taattaaaac aaagcatcgc     3660

gaaggcccgc ggcgggtgtt gacgcgatgt gatttctgcc cagtgctctg aatgtcaaag     3720

tgaagaaatt caatgaagcg cgggtaaacg gcgggagtaa ctatgactct cttaaggtag     3780

ccaaatgcct cgtcatctaa ttagtgacgc gcatgaatgg atgaacgaga ttcccactgt     3840

ccctacctac tatccagcga aaccacagcc aagggaacgg gcttggcgga atcagcgggg     3900

aaagaagacc ctgttgagct tgactctagt ctggcacggt gaagagacat gagaggtgta     3960

gaataagtgg gaggcccccg gcgccccccc ggtgtccccg cgaggggccc ggggcggggt     4020

ccgccggccc tgcgggccgc cggtgaaata ccactactct gatcgttttt tcactgaccc     4080

ggtgaggcgg gggggcgagc cccgaggggc tctcgcttct ggcgccaagc gcccggccgc     4140

gcgccggccg ggcgcgaccc gctccgggga cagtgccagg tggggagttt gactggggcg     4200

gtacacctgt caaacggtaa cgcaggtgtc ctaaggcgag ctcagggagg acagaaacct     4260

cccgtggagc agaagggcaa aagctcgctt gatcttgatt ttcagtacga atacagaccg     4320

tgaaagcggg gcctcacgat ccttctgacc ttttgggttt taagcaggag gtgtcagaaa     4380

agttaccaca gggataactg gcttgtggcg gccaagcgtt catagcgacg tcgctttttg     4440

atccttcgat gtcggctctt cctatcattg tgaagcagaa ttcaccaagc gttggattgt     4500

tcacccacta atagggaacg tgagctgggt ttagaccgtc gtgagacagg ttagttttac     4560

cctactgatg atgtgttgtt gccatggtaa tcctgctcag tacgagagga accgcaggtt     4620

cagacatttg gtgtatgtgc ttggctgagg agccaatggg gcgaagctac catctgtggg     4680

attatgactg aacgcctcta agtcagaatc ccgcccaggc ggaacgatac ggcagcgccg     4740

cggagcctcg gttggcctcg gatagccggt cccccgcctg tccccgccgg cgggccgccc     4800

cccccctcca cgcgccccgc gcgcgcggga gggcgcgtgc cccgccgcgc gccgggaccg     4860

gggtccggtg cggagtgccc ttcgtcctgg gaaacggggc gcggccggag aggcggccgc     4920

cccctcgccc gtcacgcacc gcacgttcgt ggggaacctg gcgctaaacc attcgtagac     4980

gacctgcttc tgggtcgggg tttcgtacgt agcagagcag ctccctcgct gcgatctatt     5040

gaaagtcagc cctcgacaca agggtttgtc                                      5070


<210>  2
<211>  1869
<212>  DNA
<213>  Homo sapiens

<400>  2
tacctggttg atcctgccag tagcatatgc ttgtctcaaa gattaagcca tgcatgtctg       60

agtacgcacg gccggtacag tgaaactgcg aatggctcat taaatcagtt atggttcctt      120

tggtcgctcg ctcctctcct acttggataa ctgtggtaat tctagagcta atacatgccg      180

acgggcgctg acccccttcg cgggggggat gcgtgcattt atcagatcaa aaccaacccg      240

gtcagcccct ctccggcccc ggccgggggg cgggcgccgg cggctttggt gactctagat      300

aacctcgggc cgatcgcacg ccccccgtgg cggcgacgac ccattcgaac gtctgcccta      360

tcaactttcg atggtagtcg ccgtgcctac catggtgacc acgggtgacg gggaatcagg      420

gttcgattcc ggagagggag cctgagaaac ggctaccaca tccaaggaag gcagcaggcg      480

cgcaaattac ccactcccga cccggggagg tagtgacgaa aaataacaat acaggactct      540

ttcgaggccc tgtaattgga atgagtccac tttaaatcct ttaacgagga tccattggag      600

ggcaagtctg gtgccagcag ccgcggtaat tccagctcca atagcgtata ttaaagttgc      660

tgcagttaaa aagctcgtag ttggatcttg ggagcgggcg ggcggtccgc cgcgaggcga      720

gccaccgccc gtccccgccc cttgcctctc ggcgccccct cgatgctctt agctgagtgt      780

cccgcggggc ccgaagcgtt tactttgaaa aaattagagt gttcaaagca ggcccgagcc      840

gcctggatac cgcagctagg aataatggaa taggaccgcg gttctatttt gttggttttc      900

ggaactgagg ccatgattaa gagggacggc cgggggcatt cgtattgcgc cgctagaggt      960

gaaattcttg gaccggcgca agacggacca gagcgaaagc atttgccaag aatgttttca     1020

ttaatcaaga acgaaagtcg gaggttcgaa gacgatcaga taccgtcgta gttccgacca     1080

taaacgatgc cgaccggcga tgcggcggcg ttattcccat gacccgccgg gcagcttccg     1140

ggaaaccaaa gtctttgggt tccgggggga gtatggttgc aaagctgaaa cttaaaggaa     1200

ttgacggaag ggcaccacca ggagtggagc ctgcggctta atttgactca acacgggaaa     1260

cctcacccgg cccggacacg gacaggattg acagattgat agctctttct cgattccgtg     1320

ggtggtggtg catggccgtt cttagttggt ggagcgattt gtctggttaa ttccgataac     1380

gaacgagact ctggcatgct aactagttac gcgacccccg agcggtcggc gtcccccaac     1440

ttcttagagg gacaagtggc gttcagccac ccgagattga gcaataacag gtctgtgatg     1500

cccttagatg tccggggctg cacgcgcgct acactgactg gctcagcgtg tgcctaccct     1560

acgccggcag gcgcgggtaa cccgttgaac cccattcgtg atggggatcg gggattgcaa     1620

ttattcccca tgaacgagga attcccagta agtgcgggtc ataagcttgc gttgattaag     1680

tccctgccct ttgtacacac cgcccgtcgc tactaccgat tggatggttt agtgaggccc     1740

tcggatcggc cccgccgggg tcggcccacg gccctggcgg agcgctgaga agacggtcga     1800

acttgactat ctagaggaag taaaagtcgt aacaaggttt ccgtaggtga acctgcggaa     1860

ggatcatta                                                             1869


<210>  3
<211>  157
<212>  DNA
<213>  Homo sapiens

<400>  3
cgactcttag cggtggatca ctcggctcgt gcgtcgatga agaacgcagc tagctgcgag       60

aattaatgtg aattgcagga cacattgatc atcgacactt cgaacgcact tgcggccccg      120

ggttcctccc ggggctacgc ctgtctgagc gtcgctt                               157


