                         SEQUENCE LISTING

<110>  Innate Pharma
 
<120>  Treatment of cancer

<130>  Nectin-4-2 PCT

<140>  PCT/EP2021/082872
<141>  2021-11-24

<150>  US 63/118,198
<151>  2020-11-25

<150>  US 63/229,589
<151>  2020-08-05

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial

<400>  1

Met Pro Leu Ser Leu Gly Ala Glu Met Trp Gly Pro Glu Ala Trp Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Ser Phe Thr Gly Arg Cys Pro Ala Gly 
            20                  25                  30          


Glu Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp Ala 
        35                  40                  45              


Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly Gln 
    50                  55                  60                  


Val Ala Trp Ala Arg Val Asp Ala Gly Glu Gly Ala Gln Glu Leu Ala 
65                  70                  75                  80  


Leu Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu Gly 
                85                  90                  95      


Arg Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser Val 
            100                 105                 110         


Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys Arg 
        115                 120                 125             


Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Leu Arg Leu Arg 
    130                 135                 140                 


Val Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu Glu 
145                 150                 155                 160 


Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser 
                165                 170                 175     


Pro Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr Ser 
            180                 185                 190         


Ser Arg Ser Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu Phe 
        195                 200                 205             


His Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val 
    210                 215                 220                 


Val Ser His Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Ile Leu 
225                 230                 235                 240 


His Val Ser Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp Gln 
                245                 250                 255     


Asn Leu Trp His Ile Gly Arg Glu Gly Ala Met Leu Lys Cys Leu Ser 
            260                 265                 270         


Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp Thr Arg Leu Asp Gly Pro 
        275                 280                 285             


Leu Pro Ser Gly Val Arg Val Asp Gly Asp Thr Leu Gly Phe Pro Pro 
    290                 295                 300                 


Leu Thr Thr Glu His Ser Gly Ile Tyr Val Cys His Val Ser Asn Glu 
305                 310                 315                 320 


Phe Ser Ser Arg Asp Ser Gln Val Thr Val Asp Val Leu Asp Pro Gln 
                325                 330                 335     


Glu Asp Ser Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Val Val 
            340                 345                 350         


Val Gly Val Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val Val 
        355                 360                 365             


Val Leu Met Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr Gln 
    370                 375                 380                 


Lys Tyr Glu Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg Arg 
385                 390                 395                 400 


Leu His Ser His His Thr Asp Pro Arg Ser Gln Pro Glu Glu Ser Val 
                405                 410                 415     


Gly Leu Arg Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser Ser 
            420                 425                 430         


Cys Ser Val Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr Leu 
        435                 440                 445             


Thr Thr Val Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro Gly 
    450                 455                 460                 


Ser Gly Arg Ala Glu Glu Glu Glu Asp Gln Asp Glu Gly Ile Lys Gln 
465                 470                 475                 480 


Ala Met Asn His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys Pro 
                485                 490                 495     


Thr Gly Asn Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val 
            500                 505                 510 


<210>  2
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial

<400>  2

Gly Arg Cys Pro Ala Gly Glu Leu Glu Thr Ser Asp Val Val Thr Val 
1               5                   10                  15      


Val Leu Gly Gln Asp Ala Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser 
            20                  25                  30          


Gly Glu Gln Val Gly Gln Val Ala Trp Ala Arg Val Asp Ala Gly Glu 
        35                  40                  45              


Gly Ala Gln Glu Leu Ala Leu Leu His Ser Lys Tyr Gly Leu His Val 
    50                  55                  60                  


Ser Pro Ala Tyr Glu Gly Arg Val Glu Gln Pro Pro Pro Pro Arg Asn 
65                  70                  75                  80  


Pro Leu Asp Gly Ser Val Leu Leu Arg Asn Ala Val Gln Ala Asp Glu 
                85                  90                  95      


Gly Glu Tyr Glu Cys Arg Val Ser Thr Phe Pro Ala Gly Ser Phe Gln 
            100                 105                 110         


Ala Arg Leu Arg Leu Arg Val Leu Val Pro Pro Leu Pro Ser Leu Asn 
        115                 120                 125             


Pro Gly Pro Ala Leu Glu Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser 
    130                 135                 140                 


Cys Thr Ala Glu Gly Ser Pro Ala Pro Ser Val Thr Trp Asp Thr Glu 
145                 150                 155                 160 


Val Lys Gly Thr Thr Ser Ser Arg Ser Phe Lys His Ser Arg Ser Ala 
                165                 170                 175     


Ala Val Thr Ser Glu Phe His Leu Val Pro Ser Arg Ser Met Asn Gly 
            180                 185                 190         


Gln Pro Leu Thr Cys Val Val Ser His Pro Gly Leu Leu Gln Asp Gln 
        195                 200                 205             


Arg Ile Thr His Ile Leu His Val Ser Phe Leu Ala Glu Ala Ser Val 
    210                 215                 220                 


Arg Gly Leu Glu Asp Gln Asn Leu Trp His Ile Gly Arg Glu Gly Ala 
225                 230                 235                 240 


Met Leu Lys Cys Leu Ser Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp 
                245                 250                 255     


Thr Arg Leu Asp Gly Pro Leu Pro Ser Gly Val Arg Val Asp Gly Asp 
            260                 265                 270         


Thr Leu Gly Phe Pro Pro Leu Thr Thr Glu His Ser Gly Ile Tyr Val 
        275                 280                 285             


Cys His Val Ser Asn Glu Phe Ser Ser Arg Asp Ser Gln Val Thr Val 
    290                 295                 300                 


Asp Val Leu Asp Pro Gln Glu Asp Ser Gly Lys Gln Val Asp Leu Val 
305                 310                 315                 320 


Ser Ala Ser Val Val 
                325 


<210>  3
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Glu Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp 
1               5                   10                  15      


Ala Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly 
            20                  25                  30          


Gln Val Ala Trp Ala Arg Val Asp Ala Gly Glu Gly Ala Gln Glu Leu 
        35                  40                  45              


Ala Leu Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu 
    50                  55                  60                  


Gly Arg Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser 
65                  70                  75                  80  


Val Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys 
                85                  90                  95      


Arg Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Leu Arg Leu 
            100                 105                 110         


Arg 
    


<210>  4
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  4

Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu Glu Glu Gly Gln 
1               5                   10                  15      


Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser Pro Ala Pro 
            20                  25                  30          


Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr Ser Ser Arg Ser 
        35                  40                  45              


Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu Phe His Leu Val 
    50                  55                  60                  


Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val Val Ser His 
65                  70                  75                  80  


Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr 
                85                  90  


<210>  5
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Ser Val Arg Gly Leu Glu Asp Gln Asn Leu Trp His Ile Gly Arg 
1               5                   10                  15      


Glu Gly Ala Met Leu Lys Cys Leu Ser Glu Gly Gln Pro Pro Pro Ser 
            20                  25                  30          


Tyr Asn Trp Thr Arg Leu Asp Gly Pro Leu Pro Ser Gly Val Arg Val 
        35                  40                  45              


Asp Gly Asp Thr Leu Gly Phe Pro Pro Leu Thr Thr Glu His Ser Gly 
    50                  55                  60                  


Ile Tyr Val Cys His Val Ser Asn Glu Phe Ser Ser Arg Asp Ser Gln 
65                  70                  75                  80  


Val Thr Val Asp Val Leu Asp Pro Gln Glu Asp Ser Gly Lys Gln Val 
                85                  90                  95      


Asp Leu Val Ser Ala Ser Val 
            100             


<210>  6
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  6

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Leu Asp Lys Ser Ser Ser Thr Thr Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Tyr Gly Asn Tyr Gly Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  7
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  7

Asp Val Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  8
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  8

Ser Tyr Trp Met His 
1               5   


<210>  9
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  9

Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  10
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  10

Gly Tyr Gly Asn Tyr Gly Asp Tyr 
1               5               


<210>  11
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  11

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  12
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  12

Gln Met Ser Asn Leu Ala Ser 
1               5           


<210>  13
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  13

Ala Gln Asn Leu Glu Leu Pro Trp Thr 
1               5                   


<210>  14
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  14

Gly Tyr Ile Phe Thr Ser Tyr Trp 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  15

Ile Asp Pro Ser Asp Ser Tyr Thr 
1               5               


<210>  16
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  16

Val Arg Gly Tyr Gly Asn Tyr Gly Asp Tyr 
1               5                   10  


<210>  17
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  17

Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
1               5                   10      


<210>  18
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  18

Gln Met Ser 
1           


<210>  19
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  19

Gly Tyr Ile Phe Thr Ser Tyr 
1               5           


<210>  20
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  20

Pro Ser Asp Ser 
1               


<210>  21
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  21

Tyr Gly Asn Tyr Gly Asp 
1               5       


<210>  22
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  22

Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
1               5                   10          


<210>  23
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  23

Asn Leu Glu Leu Pro Trp 
1               5       


<210>  24
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  24

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Tyr Gly Asn Tyr Gly Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  25
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  25

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  26
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  26

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  27
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  27

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  28
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  28

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Leu Ile His Ala Met Asp Asn Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  29
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Asn Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Phe Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  30
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial

<400>  30

Gly Glu Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp 
1               5                   10                  15      


Ala Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly 
            20                  25                  30          


Gln Val Ala Trp Ala Arg Val Asp Ala Gly Glu Gly Ala Gln Glu Leu 
        35                  40                  45              


Ala Leu Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu 
    50                  55                  60                  


Gly Arg Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser 
65                  70                  75                  80  


Val Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys 
                85                  90                  95      


Arg Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Leu Arg Leu 
            100                 105                 110         


Arg Val Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu 
        115                 120                 125             


Glu Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly 
    130                 135                 140                 


Ser Pro Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr 
145                 150                 155                 160 


Ser Ser Arg Ser Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu 
                165                 170                 175     


Phe His Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys 
            180                 185                 190         


Val Val Ser His Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Ile 
        195                 200                 205             


Leu His Val Ser Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp 
    210                 215                 220                 


Gln Asn Leu Trp His Ile Gly Arg Glu Gly Ala Met Leu Lys Cys Leu 
225                 230                 235                 240 


Ser Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp Thr Arg Leu Asp Gly 
                245                 250                 255     


Pro Leu Pro Ser Gly Val Arg Val Asp Gly Asp Thr Leu Gly Phe Pro 
            260                 265                 270         


Pro Leu Thr Thr Glu His Ser Gly Ile Tyr Val Cys His Val Ser Asn 
        275                 280                 285             


Glu Phe Ser Ser Arg Asp Ser Gln Val Thr Val Asp Val Leu Asp Pro 
    290                 295                 300                 


Gln Glu Asp Ser Gly Lys Gln Val Asp Leu Val Ser Ala Ser His His 
305                 310                 315                 320 


His His His His Leu His His Ile Leu Asp Ala Gln Lys Met Val Trp 
                325                 330                 335     


Asn His Arg 
            


<210>  31
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  31

Gly Glu Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp 
1               5                   10                  15      


Ala Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly 
            20                  25                  30          


Gln Val Ala Trp Ala Arg Val Asp Ala Gly Glu Gly Ala Gln Glu Leu 
        35                  40                  45              


Ala Leu Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu 
    50                  55                  60                  


Gly Arg Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser 
65                  70                  75                  80  


Val Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys 
                85                  90                  95      


Arg Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Leu Arg Leu 
            100                 105                 110         


Arg Val Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu 
        115                 120                 125             


Glu Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly 
    130                 135                 140                 


Ser Pro Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr 
145                 150                 155                 160 


Ser Ser Arg Ser Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu 
                165                 170                 175     


Phe His Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys 
            180                 185                 190         


Val Val Ser His Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Ile 
        195                 200                 205             


Leu His Val Ser Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp 
    210                 215                 220                 


Gln Asn Leu Trp His Ile Gly Arg Glu Gly Ala Met Leu Lys Cys Leu 
225                 230                 235                 240 


Ser Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp Thr Arg Leu Asp Gly 
                245                 250                 255     


Pro Leu Pro Ser Gly Val Arg Val Asp Gly Asp Thr Leu Gly Phe Pro 
            260                 265                 270         


Pro Leu Thr Thr Glu His Ser Gly Ile Tyr Val Cys His Val Ser Asn 
        275                 280                 285             


Glu Phe Ser Ser Arg Asp Ser Gln Val Thr Val Asp Val Leu Asp Pro 
    290                 295                 300                 


Gln Glu Asp Ser Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Val 
305                 310                 315                 320 


Val Val Gly Val Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val 
                325                 330                 335     


Val Val Leu Met Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr 
            340                 345                 350         


Gln Lys Tyr Glu Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg 
        355                 360                 365             


Arg Leu His Ser His His Thr Asp Pro Arg Ser Gln Pro Glu Glu Ser 
    370                 375                 380                 


Val Gly Leu Arg Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser 
385                 390                 395                 400 


Ser Cys Ser Val Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr 
                405                 410                 415     


Leu Thr Thr Val Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro 
            420                 425                 430         


Gly Ser Gly Arg Ala Glu Glu Glu Glu Asp Gln Asp Glu Gly Ile Lys 
        435                 440                 445             


Gln Ala Met Asn His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys 
    450                 455                 460                 


Pro Thr Gly Asn Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val 
465                 470                 475                 


<210>  32
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  32

Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu Glu Glu Gly Gln 
1               5                   10                  15      


Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser Pro Ala Pro 
            20                  25                  30          


Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr Ser Ser Arg Ser 
        35                  40                  45              


Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu Phe His Leu Val 
    50                  55                  60                  


Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val Val Ser His 
65                  70                  75                  80  


Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Ile Leu His Val Ser 
                85                  90                  95      


Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp Gln Asn Leu Trp 
            100                 105                 110         


His Ile Gly Arg Glu Gly Ala Met Leu Lys Cys Leu Ser Glu Gly Gln 
        115                 120                 125             


Pro Pro Pro Ser Tyr Asn Trp Thr Arg Leu Asp Gly Pro Leu Pro Ser 
    130                 135                 140                 


Gly Val Arg Val Asp Gly Asp Thr Leu Gly Phe Pro Pro Leu Thr Thr 
145                 150                 155                 160 


Glu His Ser Gly Ile Tyr Val Cys His Val Ser Asn Glu Phe Ser Ser 
                165                 170                 175     


Arg Asp Ser Gln Val Thr Val Asp Val Leu Asp Pro Gln Glu Asp Ser 
            180                 185                 190         


Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Val Val Val Gly Val 
        195                 200                 205             


Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val Val Val Leu Met 
    210                 215                 220                 


Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr Gln Lys Tyr Glu 
225                 230                 235                 240 


Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg Arg Leu His Ser 
                245                 250                 255     


His His Thr Asp Pro Arg Ser Gln Pro Glu Glu Ser Val Gly Leu Arg 
            260                 265                 270         


Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser Ser Cys Ser Val 
        275                 280                 285             


Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr Leu Thr Thr Val 
    290                 295                 300                 


Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro Gly Ser Gly Arg 
305                 310                 315                 320 


Ala Glu Glu Glu Glu Asp Gln Asp Glu Gly Ile Lys Gln Ala Met Asn 
                325                 330                 335     


His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys Pro Thr Gly Asn 
            340                 345                 350         


Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val 
        355                 360             


<210>  33
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  33

Ala Ser Val Arg Gly Leu Glu Asp Gln Asn Leu Trp His Ile Gly Arg 
1               5                   10                  15      


Glu Gly Ala Met Leu Lys Cys Leu Ser Glu Gly Gln Pro Pro Pro Ser 
            20                  25                  30          


Tyr Asn Trp Thr Arg Leu Asp Gly Pro Leu Pro Ser Gly Val Arg Val 
        35                  40                  45              


Asp Gly Asp Thr Leu Gly Phe Pro Pro Leu Thr Thr Glu His Ser Gly 
    50                  55                  60                  


Ile Tyr Val Cys His Val Ser Asn Glu Phe Ser Ser Arg Asp Ser Gln 
65                  70                  75                  80  


Val Thr Val Asp Val Leu Asp Pro Gln Glu Asp Ser Gly Lys Gln Val 
                85                  90                  95      


Asp Leu Val Ser Ala Ser Val Val Val Val Gly Val Ile Ala Ala Leu 
            100                 105                 110         


Leu Phe Cys Leu Leu Val Val Val Val Val Leu Met Ser Arg Tyr His 
        115                 120                 125             


Arg Arg Lys Ala Gln Gln Met Thr Gln Lys Tyr Glu Glu Glu Leu Thr 
    130                 135                 140                 


Leu Thr Arg Glu Asn Ser Ile Arg Arg Leu His Ser His His Thr Asp 
145                 150                 155                 160 


Pro Arg Ser Gln Pro Glu Glu Ser Val Gly Leu Arg Ala Glu Gly His 
                165                 170                 175     


Pro Asp Ser Leu Lys Asp Asn Ser Ser Cys Ser Val Met Ser Glu Glu 
            180                 185                 190         


Pro Glu Gly Arg Ser Tyr Ser Thr Leu Thr Thr Val Arg Glu Ile Glu 
        195                 200                 205             


Thr Gln Thr Glu Leu Leu Ser Pro Gly Ser Gly Arg Ala Glu Glu Glu 
    210                 215                 220                 


Glu Asp Gln Asp Glu Gly Ile Lys Gln Ala Met Asn His Phe Val Gln 
225                 230                 235                 240 


Glu Asn Gly Thr Leu Arg Ala Lys Pro Thr Gly Asn Gly Ile Tyr Ile 
                245                 250                 255     


Asn Gly Arg Gly His Leu Val 
            260             


<210>  34
<211>  477
<212>  PRT
<213>  Mus musculus

<400>  34

Glu Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp Ala 
1               5                   10                  15      


Lys Leu Pro Cys Phe Tyr Arg Gly Asp Pro Asp Glu Gln Val Gly Gln 
            20                  25                  30          


Val Ala Trp Ala Arg Val Asp Pro Asn Glu Gly Ile Arg Glu Leu Ala 
        35                  40                  45              


Leu Leu His Ser Lys Tyr Gly Leu His Val Asn Pro Ala Tyr Glu Asp 
    50                  55                  60                  


Arg Val Glu Gln Pro Pro Pro Pro Arg Asp Pro Leu Asp Gly Ser Val 
65                  70                  75                  80  


Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys Arg 
                85                  90                  95      


Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Met Arg Leu Arg 
            100                 105                 110         


Val Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Pro Leu Glu 
        115                 120                 125             


Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser 
    130                 135                 140                 


Pro Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Gln Ser 
145                 150                 155                 160 


Ser Arg Ser Phe Thr His Pro Arg Ser Ala Ala Val Thr Ser Glu Phe 
                165                 170                 175     


His Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val 
            180                 185                 190         


Val Ser His Pro Gly Leu Leu Gln Asp Arg Arg Ile Thr His Thr Leu 
        195                 200                 205             


Gln Val Ala Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp Gln 
    210                 215                 220                 


Asn Leu Trp Gln Val Gly Arg Glu Gly Ala Thr Leu Lys Cys Leu Ser 
225                 230                 235                 240 


Glu Gly Gln Pro Pro Pro Lys Tyr Asn Trp Thr Arg Leu Asp Gly Pro 
                245                 250                 255     


Leu Pro Ser Gly Val Arg Val Lys Gly Asp Thr Leu Gly Phe Pro Pro 
            260                 265                 270         


Leu Thr Thr Glu His Ser Gly Val Tyr Val Cys His Val Ser Asn Glu 
        275                 280                 285             


Leu Ser Ser Arg Asp Ser Gln Val Thr Val Glu Val Leu Asp Pro Glu 
    290                 295                 300                 


Asp Pro Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Ile Ile Val 
305                 310                 315                 320 


Gly Val Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val Val Val 
                325                 330                 335     


Leu Met Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr Gln Lys 
            340                 345                 350         


Tyr Glu Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg Arg Leu 
        355                 360                 365             


His Ser His His Ser Asp Pro Arg Ser Gln Pro Glu Glu Ser Val Gly 
    370                 375                 380                 


Leu Arg Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser Ser Cys 
385                 390                 395                 400 


Ser Val Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr Leu Thr 
                405                 410                 415     


Thr Val Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro Gly Ser 
            420                 425                 430         


Gly Arg Thr Glu Glu Asp Asp Asp Gln Asp Glu Gly Ile Lys Gln Ala 
        435                 440                 445             


Met Asn His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys Pro Thr 
    450                 455                 460                 


Gly Asn Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val 
465                 470                 475         


<210>  35
<211>  508
<212>  PRT
<213>  Rattus rattus

<400>  35

Met Pro Leu Ser Leu Gly Ala Glu Met Trp Gly Pro Glu Ala Trp Leu 
1               5                   10                  15      


Leu Leu Leu Phe Leu Ala Ser Phe Thr Gly Arg Tyr Ser Ala Gly Glu 
            20                  25                  30          


Leu Glu Thr Ser Asp Leu Val Thr Val Val Leu Gly Gln Asp Ala Lys 
        35                  40                  45              


Leu Pro Cys Phe Tyr Arg Gly Asp Pro Asp Glu Gln Val Gly Gln Val 
    50                  55                  60                  


Ala Trp Ala Arg Val Asp Pro Asn Glu Gly Thr Arg Glu Leu Ala Leu 
65                  70                  75                  80  


Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu Asp Arg 
                85                  90                  95      


Val Glu Gln Pro Pro Pro Pro Arg Asp Pro Leu Asp Gly Ser Ile Leu 
            100                 105                 110         


Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys Arg Val 
        115                 120                 125             


Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Met Arg Leu Arg Val 
    130                 135                 140                 


Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Pro Leu Glu Glu 
145                 150                 155                 160 


Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser Pro 
                165                 170                 175     


Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Gln Ser Ser 
            180                 185                 190         


Arg Ser Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu Phe His 
        195                 200                 205             


Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val Val 
    210                 215                 220                 


Ser His Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Thr Leu Gln 
225                 230                 235                 240 


Val Ala Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp Gln Asn 
                245                 250                 255     


Leu Trp His Val Gly Arg Glu Gly Ala Thr Leu Lys Cys Leu Ser Glu 
            260                 265                 270         


Gly Gln Pro Pro Pro Lys Tyr Asn Trp Thr Arg Leu Asp Gly Pro Leu 
        275                 280                 285             


Pro Ser Gly Val Arg Val Lys Gly Asp Thr Leu Gly Phe Pro Pro Leu 
    290                 295                 300                 


Thr Thr Glu His Ser Gly Val Tyr Val Cys His Val Ser Asn Glu Leu 
305                 310                 315                 320 


Ser Ser Arg Ala Ser Gln Val Thr Val Glu Val Leu Asp Pro Glu Asp 
                325                 330                 335     


Pro Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Val Val Val Gly 
            340                 345                 350         


Val Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val Val Val Leu 
        355                 360                 365             


Met Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr Gln Lys Tyr 
    370                 375                 380                 


Glu Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg Arg Leu His 
385                 390                 395                 400 


Ser His His Thr Asp Pro Arg Ser Gln Pro Glu Glu Ser Val Gly Leu 
                405                 410                 415     


Arg Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser Ser Cys Ser 
            420                 425                 430         


Val Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr Leu Thr Thr 
        435                 440                 445             


Val Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro Gly Ser Gly 
    450                 455                 460                 


Arg Thr Glu Glu Glu Asp Asp Gln Asp Glu Gly Ile Lys Gln Ala Met 
465                 470                 475                 480 


Asn His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys Pro Thr Gly 
                485                 490                 495     


Asn Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val 
            500                 505             


<210>  36
<211>  479
<212>  PRT
<213>  Canis lupus

<400>  36

Gly Glu Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp 
1               5                   10                  15      


Ala Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly 
            20                  25                  30          


Gln Val Ala Trp Ala Arg Ala Asp Ala Gly Glu Gly Ala Gln Glu Leu 
        35                  40                  45              


Ala Leu Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu 
    50                  55                  60                  


Gly Arg Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser 
65                  70                  75                  80  


Val Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys 
                85                  90                  95      


Arg Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Leu Arg Leu 
            100                 105                 110         


Arg Val Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu 
        115                 120                 125             


Glu Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly 
    130                 135                 140                 


Ser Pro Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr 
145                 150                 155                 160 


Ser Ser Arg Ser Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu 
                165                 170                 175     


Phe His Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys 
            180                 185                 190         


Val Val Ser His Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Ile 
        195                 200                 205             


Leu His Val Ser Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp 
    210                 215                 220                 


Gln Asn Leu Trp His Val Gly Arg Glu Gly Ala Met Leu Lys Cys Leu 
225                 230                 235                 240 


Ser Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp Thr Arg Leu Asp Gly 
                245                 250                 255     


Pro Leu Pro Ser Gly Val Arg Val Asp Gly Asp Thr Leu Gly Phe Pro 
            260                 265                 270         


Pro Leu Thr Thr Glu His Ser Gly Ile Tyr Val Cys His Val Ser Asn 
        275                 280                 285             


Glu Phe Ser Ser Arg Asp Ser Gln Val Thr Val Asp Val Leu Asp Pro 
    290                 295                 300                 


Gln Glu Asp Ser Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Val 
305                 310                 315                 320 


Val Val Gly Val Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val 
                325                 330                 335     


Val Val Leu Met Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr 
            340                 345                 350         


Gln Lys Tyr Glu Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg 
        355                 360                 365             


Arg Leu His Ser His His Thr Asp Pro Arg Ser Gln Pro Glu Glu Ser 
    370                 375                 380                 


Val Gly Leu Arg Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser 
385                 390                 395                 400 


Ser Cys Ser Val Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr 
                405                 410                 415     


Leu Thr Thr Val Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro 
            420                 425                 430         


Gly Ser Gly Arg Thr Glu Glu Glu Glu Asp Gln Asp Glu Gly Ile Lys 
        435                 440                 445             


Gln Ala Met Asn His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys 
    450                 455                 460                 


Pro Thr Gly Asn Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val 
465                 470                 475                 


<210>  37
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gly Leu Ala Gly Ala Ala Gly Arg Trp Trp Gly Leu Ala Leu Gly 
1               5                   10                  15      


Leu Thr Ala Phe Phe Leu Pro Gly Val His Ser Gln Val Val Gln Val 
            20                  25                  30          


Asn Asp Ser Met Tyr Gly Phe Ile Gly Thr Asp Val Val Leu His Cys 
        35                  40                  45              


Ser Phe Ala Asn Pro Leu Pro Ser Val Lys Ile Thr Gln Val Thr Trp 
    50                  55                  60                  


Gln Lys Ser Thr Asn Gly Ser Lys Gln Asn Val Ala Ile Tyr Asn Pro 
65                  70                  75                  80  


Ser Met Gly Val Ser Val Leu Ala Pro Tyr Arg Glu Arg Val Glu Phe 
                85                  90                  95      


Leu Arg Pro Ser Phe Thr Asp Gly Thr Ile Arg Leu Ser Arg Leu Glu 
            100                 105                 110         


Leu Glu Asp Glu Gly Val Tyr Ile Cys Glu Phe Ala Thr Phe Pro Thr 
        115                 120                 125             


Gly Asn Arg Glu Ser Gln Leu Asn Leu Thr Val Met Ala Lys Pro Thr 
    130                 135                 140                 


Asn Trp Ile Glu Gly Thr Gln Ala Val Leu Arg Ala Lys Lys Gly Gln 
145                 150                 155                 160 


Asp Asp Lys Val Leu Val Ala Thr Cys Thr Ser Ala Asn Gly Lys Pro 
                165                 170                 175     


Pro Ser Val Val Ser Trp Glu Thr Arg Leu Lys Gly Glu Ala Glu Tyr 
            180                 185                 190         


Gln Glu Ile Arg Asn Pro Asn Gly Thr Val Thr Val Ile Ser Arg Tyr 
        195                 200                 205             


Arg Leu Val Pro Ser Arg Glu Ala His Gln Gln Ser Leu Ala Cys Ile 
    210                 215                 220                 


Val Asn Tyr His Met Asp Arg Phe Lys Glu Ser Leu Thr Leu Asn Val 
225                 230                 235                 240 


Gln Tyr Glu Pro Glu Val Thr Ile Glu Gly Phe Asp Gly Asn Trp Tyr 
                245                 250                 255     


Leu Gln Arg Met Asp Val Lys Leu Thr Cys Lys Ala Asp Ala Asn Pro 
            260                 265                 270         


Pro Ala Thr Glu Tyr His Trp Thr Thr Leu Asn Gly Ser Leu Pro Lys 
        275                 280                 285             


Gly Val Glu Ala Gln Asn Arg Thr Leu Phe Phe Lys Gly Pro Ile Asn 
    290                 295                 300                 


Tyr Ser Leu Ala Gly Thr Tyr Ile Cys Glu Ala Thr Asn Pro Ile Gly 
305                 310                 315                 320 


Thr Arg Ser Gly Gln Val Glu Val Asn Ile Thr Glu Phe Pro Tyr Thr 
                325                 330                 335     


Pro Ser Pro Pro Glu His Gly Arg Arg Ala Gly Pro Val Pro Thr Ala 
            340                 345                 350         


Ile Ile Gly Gly Val Ala Gly Ser Ile Leu Leu Val Leu Ile Val Val 
        355                 360                 365             


Gly Gly Ile Val Val Ala Leu Arg Arg Arg Arg His Thr Phe Lys Gly 
    370                 375                 380                 


Asp Tyr Ser Thr Lys Lys His Val Tyr Gly Asn Gly Tyr Ser Lys Ala 
385                 390                 395                 400 


Gly Ile Pro Gln His His Pro Pro Met Ala Gln Asn Leu Gln Tyr Pro 
                405                 410                 415     


Asp Asp Ser Asp Asp Glu Lys Lys Ala Gly Pro Leu Gly Gly Ser Ser 
            420                 425                 430         


Tyr Glu Glu Glu Glu Glu Glu Glu Glu Gly Gly Gly Gly Gly Glu Arg 
        435                 440                 445             


Lys Val Gly Gly Pro His Pro Lys Tyr Asp Glu Asp Ala Lys Arg Pro 
    450                 455                 460                 


Tyr Phe Thr Val Asp Glu Ala Glu Ala Arg Gln Asp Gly Tyr Gly Asp 
465                 470                 475                 480 


Arg Thr Leu Gly Tyr Gln Tyr Asp Pro Glu Gln Leu Asp Leu Ala Glu 
                485                 490                 495     


Asn Met Val Ser Gln Asn Asp Gly Ser Phe Ile Ser Lys Lys Glu Trp 
            500                 505                 510         


Tyr Val 
        


<210>  38
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Arg Ala Ala Ala Leu Leu Pro Ser Arg Ser Pro Pro Thr Pro 
1               5                   10                  15      


Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Glu Thr Gly Ala Gln 
            20                  25                  30          


Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly 
        35                  40                  45              


Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr 
    50                  55                  60                  


Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln 
65                  70                  75                  80  


Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro 
                85                  90                  95      


Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr 
            100                 105                 110         


Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His 
        115                 120                 125             


Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr 
    130                 135                 140                 


Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile Ala 
145                 150                 155                 160 


Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln Asp 
                165                 170                 175     


Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro Ala 
            180                 185                 190         


Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr Gln 
        195                 200                 205             


Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe Thr 
    210                 215                 220                 


Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys Val 
225                 230                 235                 240 


Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu Ser 
                245                 250                 255     


Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn Trp 
            260                 265                 270         


Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser Asn 
        275                 280                 285             


Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe Pro 
    290                 295                 300                 


Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val Asp 
305                 310                 315                 320 


Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val Gly 
                325                 330                 335     


Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn Thr 
            340                 345                 350         


Ala Gly Ala Gly Ala Thr Gly Gly Ile Ile Gly Gly Ile Ile Ala Ala 
        355                 360                 365             


Ile Ile Ala Thr Ala Val Ala Ala Thr Gly Ile Leu Ile Cys Arg Gln 
    370                 375                 380                 


Gln Arg Lys Glu Gln Thr Leu Gln Gly Ala Glu Glu Asp Glu Asp Leu 
385                 390                 395                 400 


Glu Gly Pro Pro Ser Tyr Lys Pro Pro Thr Pro Lys Ala Lys Leu Glu 
                405                 410                 415     


Ala Gln Glu Met Pro Ser Gln Leu Phe Thr Leu Gly Ala Ser Glu His 
            420                 425                 430         


Ser Pro Leu Lys Thr Pro Tyr Phe Asp Ala Gly Ala Ser Cys Thr Glu 
        435                 440                 445             


Gln Glu Met Pro Arg Tyr His Glu Leu Pro Thr Leu Glu Glu Arg Ser 
    450                 455                 460                 


Gly Pro Leu His Pro Gly Ala Thr Ser Leu Gly Ser Pro Ile Pro Val 
465                 470                 475                 480 


Pro Pro Gly Pro Pro Ala Val Glu Asp Val Ser Leu Asp Leu Glu Asp 
                485                 490                 495     


Glu Glu Gly Glu Glu Glu Glu Glu Tyr Leu Asp Lys Ile Asn Pro Ile 
            500                 505                 510         


Tyr Asp Ala Leu Ser Tyr Ser Ser Pro Ser Asp Ser Tyr Gln Gly Lys 
        515                 520                 525             


Gly Phe Val Met Ser Arg Ala Met Tyr Val 
    530                 535             


<210>  39
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Arg Thr Leu Arg Pro Ser Pro Leu Cys Pro Gly Gly Gly Lys 
1               5                   10                  15      


Ala Gln Leu Ser Ser Ala Ser Leu Leu Gly Ala Gly Leu Leu Leu Gln 
            20                  25                  30          


Pro Pro Thr Pro Pro Pro Leu Leu Leu Leu Leu Phe Pro Leu Leu Leu 
        35                  40                  45              


Phe Ser Arg Leu Cys Gly Ala Leu Ala Gly Pro Ile Ile Val Glu Pro 
    50                  55                  60                  


His Val Thr Ala Val Trp Gly Lys Asn Val Ser Leu Lys Cys Leu Ile 
65                  70                  75                  80  


Glu Val Asn Glu Thr Ile Thr Gln Ile Ser Trp Glu Lys Ile His Gly 
                85                  90                  95      


Lys Ser Ser Gln Thr Val Ala Val His His Pro Gln Tyr Gly Phe Ser 
            100                 105                 110         


Val Gln Gly Glu Tyr Gln Gly Arg Val Leu Phe Lys Asn Tyr Ser Leu 
        115                 120                 125             


Asn Asp Ala Thr Ile Thr Leu His Asn Ile Gly Phe Ser Asp Ser Gly 
    130                 135                 140                 


Lys Tyr Ile Cys Lys Ala Val Thr Phe Pro Leu Gly Asn Ala Gln Ser 
145                 150                 155                 160 


Ser Thr Thr Val Thr Val Leu Val Glu Pro Thr Val Ser Leu Ile Lys 
                165                 170                 175     


Gly Pro Asp Ser Leu Ile Asp Gly Gly Asn Glu Thr Val Ala Ala Ile 
            180                 185                 190         


Cys Ile Ala Ala Thr Gly Lys Pro Val Ala His Ile Asp Trp Glu Gly 
        195                 200                 205             


Asp Leu Gly Glu Met Glu Ser Thr Thr Thr Ser Phe Pro Asn Glu Thr 
    210                 215                 220                 


Ala Thr Ile Ile Ser Gln Tyr Lys Leu Phe Pro Thr Arg Phe Ala Arg 
225                 230                 235                 240 


Gly Arg Arg Ile Thr Cys Val Val Lys His Pro Ala Leu Glu Lys Asp 
                245                 250                 255     


Ile Arg Tyr Ser Phe Ile Leu Asp Ile Gln Tyr Ala Pro Glu Val Ser 
            260                 265                 270         


Val Thr Gly Tyr Asp Gly Asn Trp Phe Val Gly Arg Lys Gly Val Asn 
        275                 280                 285             


Leu Lys Cys Asn Ala Asp Ala Asn Pro Pro Pro Phe Lys Ser Val Trp 
    290                 295                 300                 


Ser Arg Leu Asp Gly Gln Trp Pro Asp Gly Leu Leu Ala Ser Asp Asn 
305                 310                 315                 320 


Thr Leu His Phe Val His Pro Leu Thr Phe Asn Tyr Ser Gly Val Tyr 
                325                 330                 335     


Ile Cys Lys Val Thr Asn Ser Leu Gly Gln Arg Ser Asp Gln Lys Val 
            340                 345                 350         


Ile Tyr Ile Ser Asp Pro Pro Thr Thr Thr Thr Leu Gln Pro Thr Ile 
        355                 360                 365             


Gln Trp His Pro Ser Thr Ala Asp Ile Glu Asp Leu Ala Thr Glu Pro 
    370                 375                 380                 


Lys Lys Leu Pro Phe Pro Leu Ser Thr Leu Ala Thr Ile Lys Asp Asp 
385                 390                 395                 400 


Thr Ile Ala Thr Ile Ile Ala Ser Val Val Gly Gly Ala Leu Phe Ile 
                405                 410                 415     


Val Leu Val Ser Val Leu Ala Gly Ile Phe Cys Tyr Arg Arg Arg Arg 
            420                 425                 430         


Thr Phe Arg Gly Asp Tyr Phe Ala Lys Asn Tyr Ile Pro Pro Ser Asp 
        435                 440                 445             


Met Gln Lys Glu Ser Gln Ile Asp Val Leu Gln Gln Asp Glu Leu Asp 
    450                 455                 460                 


Ser Tyr Pro Asp Ser Val Lys Lys Glu Asn Lys Asn Pro Val Asn Asn 
465                 470                 475                 480 


Leu Ile Arg Lys Asp Tyr Leu Glu Glu Pro Glu Lys Thr Gln Trp Asn 
                485                 490                 495     


Asn Val Glu Asn Leu Asn Arg Phe Glu Arg Pro Met Asp Tyr Tyr Glu 
            500                 505                 510         


Asp Leu Lys Met Gly Met Lys Phe Val Ser Asp Glu His Tyr Asp Glu 
        515                 520                 525             


Asn Glu Asp Asp Leu Val Ser His Val Asp Gly Ser Val Ile Ser Arg 
    530                 535                 540                 


Arg Glu Trp Tyr Val 
545                 


<210>  40
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  40

Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp 
1               5                   10                  15      


Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr 
            20                  25                  30          


His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met 
        35                  40                  45              


Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg 
    50                  55                  60                  


Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys 
                85                  90                  95      


Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu 
            100                 105                 110         


Arg Val Leu Ala Lys Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln 
        115                 120                 125             


Leu Thr Gly Glu Pro Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly 
    130                 135                 140                 


Arg Pro Pro Ala Gln Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro 
145                 150                 155                 160 


Asn Thr Ser Gln Val Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr 
                165                 170                 175     


Ser Leu Trp Ile Leu Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val 
            180                 185                 190         


Thr Cys Lys Val Glu His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr 
        195                 200                 205             


Val Asn Leu Thr Val Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr 
    210                 215                 220                 


Asp Asn Asn Trp Tyr Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Asn Pro Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met 
                245                 250                 255     


Gly Pro Leu Pro Pro Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile 
            260                 265                 270         


Arg Pro Val Asp Lys Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr 
        275                 280                 285             


Asn Ala Leu Gly Ala Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu 
    290                 295                 300                 


Gly Pro Pro Ser Glu His Ser Gly Ile Ser Arg Asn Ala Ile Ile Phe 
305                 310                 315                 320 


Leu Val Leu Gly Ile Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile 
                325                 330                 335     


Tyr Phe Tyr Trp Ser Lys Cys Ser Arg Glu Val Leu Trp His Cys His 
            340                 345                 350         


Leu Cys Pro Ser Ser Thr Glu His Ala Ser Ala Ser Ala Asn Gly His 
        355                 360                 365             


Val Ser Tyr Ser Ala Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro 
    370                 375                 380                 


Gln Thr Glu Gly Thr Arg 
385                 390 


<210>  41
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial

<400>  41

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  42
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  42

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Asn His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Lys Asn Gly Asp Ile Ile His Asn Gln Asn Phe 
    50                  55                  60                  


Met Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Cys Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Gly Ser Ser Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  43
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  43

Asp Ile Val Met Thr Gln Ser Pro Thr Ser Leu Val Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Thr Thr Pro 
            20                  25                  30          


Arg Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  44
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  44

Glu Tyr Thr Ile His 
1               5   


<210>  45
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  45

Arg Ile Asn Pro Lys Asn Gly Asp Ile Ile His Asn Gln Asn Phe Met 
1               5                   10                  15      


Gly 
    


<210>  46
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  46

Ser Gly Tyr Gly Ser Ser Tyr Gly Phe Ala Tyr 
1               5                   10      


<210>  47
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  47

Arg Ala Ser Gln Ser Val Thr Thr Pro Arg Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  48
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  48

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  49
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  49

Gln His Ser Trp Glu Ile Pro Tyr Thr 
1               5                   


<210>  50
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  50

Gln Val Gln Leu Lys Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ile Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Asn Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ala 
        115             


<210>  51
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  51

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Ser Ala Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro His Phe Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  52
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  52

Ser Tyr Trp Met His 
1               5   


<210>  53
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  53

Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  54
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  54

Ser Gly Asn Tyr Asp Ala Met Asp Tyr 
1               5                   


<210>  55
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  55

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  56
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  56

Gln Met Ser Asn Leu Ala Ser 
1               5           


<210>  57
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  57

Ala Gln Asn Leu Glu Leu Pro Trp Thr 
1               5                   


