                         SEQUENCE LISTING

<110>  SHANGHAI BENEMAE PHARMACEUTICAL CORPORATION
 
<120>  NOVEL ANTI-LAG3 ANTIBODIES AND METHODS OF MAKING AND USING THE 
       SAME

<130>  057783-8019.WO01

<150>  PCT/US20/132111
<151>  2020-11-27

<160>  112   

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  1

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Asn Tyr Ser Asp Cys Arg Gly Pro Tyr His Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  2
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  2

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Leu Ser Gly Ser Gly Tyr Gly Cys Arg Gly Pro Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  3
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  3

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Gly Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Leu 
        35                  40                  45              


Ala Cys Ile Ser Gly Ser Asp Gly Ser Thr His Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Met Ala 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Phe Gly Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Gly Ser Cys Ser Gly Ser Trp Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  4
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  4

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asn Glu His 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr His Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Asn Met Ser Arg Asp Asp Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Leu Gly Arg Asp Cys Gln Gly Gly Gln Trp Lys Thr Ser 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  5
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  5

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Gly Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Gly Leu 
        35                  40                  45              


Ser Cys Ile Ser Gly Ser Asp Gly Ser Thr His Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Met Ala 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Phe Gly Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Gly Ser Cys Ser Gly Ser Trp Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  6
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  6

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Gly Tyr 
            20                  25                  30          


Ala Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Leu 
        35                  40                  45              


Ser Cys Ile Ser Gly Thr Asp Gly Ser Thr His Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Met Ala 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Phe Gly Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Gly Ser Cys Ser Gly Ser Trp Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Ile Thr Val Ser Ser 
        115                 120 


<210>  7
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  7

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asn Glu His 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr His Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asp Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Leu Gly Arg Asp Cys Gln Gly Gly Gln Trp Lys Thr Ser 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  8
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  8

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Glu Ser Phe Ser 
            20                  25                  30          


Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr Tyr Thr Asp 
    50                  55                  60                  


Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly Arg Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  9
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Thr Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Tyr Ser Asp Cys Arg Gly Pro Tyr Glu Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  10
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Tyr Gly Asp Cys Arg Gly Pro Tyr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  11
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  11

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Phe Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ser Ser Arg Asp Asn Ala Lys Asp Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Arg Arg Gly Tyr Gly Cys Ser Gly Pro Trp His Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  12
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  12

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asn Glu His 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr His Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asp Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Leu Gly Arg Asp Cys Gln Gly Gly Gln Trp Lys Thr Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  13
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  13

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe Asp Asp Thr 
            20                  25                  30          


Ala Thr Gly Trp Phe Arg Gln Ala Pro Gly Lys Asn Arg Glu Gly Val 
        35                  40                  45              


Ala Cys Ile Ser Ser Ser Asp Gly Arg Ile His Tyr Ile Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Lys Gly Ser Thr Asp Cys Gln Gly Ala Ile Trp Gly 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Ile Val Ser Ser 
        115                 120                 


<210>  14
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  14

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Tyr Gly Asp Cys Arg Gly Pro Tyr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  15
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  15

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Ser Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Cys Ile Thr Ser Ser Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Trp Gln Thr Cys Thr Gly Pro Tyr Asp His Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  16
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  16

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asn Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Arg Asn Ala Gly Ser Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Val Pro Asp Tyr Gly Asp Ile Thr Asp Cys Gly Gly Lys 
            100                 105                 110         


Trp Asp Asp Tyr Trp Gly Pro Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  17
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  17

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asp Asp Tyr 
            20                  25                  30          


Ser Ile Gly Trp Phe Arg Gln Ala Pro Gly Arg His Arg Glu Val Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Thr Lys Tyr Ala Asp Ser Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asn Asn Ala Glu Asp Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
                85                  90                  95      


Arg Ser Gly Asp Gly Cys Asn Gly Arg Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  18
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  18

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Thr Val Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Gly Ile His Gly Thr Ser Cys Asn Thr Ser Trp Lys Tyr 
            100                 105                 110         


Tyr Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  19
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  19

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Cys Ile Ser Gly Ser Asp Gly Gly Thr His Tyr His Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asn Lys Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gln Ala Asp Arg Cys Leu Gly Gly Ile Trp Pro Thr Gly 
            100                 105                 110         


Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  20

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  21

Gly Phe Thr Leu Asp Tyr Tyr Ala 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  22

Gly Leu Thr Leu Asp Gly Tyr Ala 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  23

Gly Phe Thr Leu Asn Glu His Ala 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  24

Gly Ser Ile Glu Ser Phe Ser Phe 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  25

Gly Phe Phe Phe Asp Asp Tyr Ala 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  26

Gly Phe Thr Phe Asp Asp Thr Ala 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  27

Gly Phe Thr Leu Asp Ser Tyr Ala 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  28

Gly Phe Thr Leu Asp Asn Tyr Ala 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  29

Gly Phe Ile Phe Asp Asp Tyr Ser 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  30

Gly Phe Thr Leu Asp Tyr Tyr Thr 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  31

Gly Phe Thr Leu Asp Asp Tyr Ala 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  32

Ile Arg Ser Ser Asp Gly Ser Thr 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  33

Ile Ser Ser Ser Asp Gly Ser Thr 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  34

Ile Ser Gly Ser Asp Gly Ser Thr 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  35

Ile Ser Gly Thr Asp Gly Ser Thr 
1               5               


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  36

Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser 
1               5                   10  


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  37

Ile Ser Ser Ser Asp Gly Arg Ile 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  38

Ile Thr Ser Ser Asp Gly Arg Thr 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  39

Ile Ser Arg Asn Ala Gly Ser Thr 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  40

Ile Ser Ser Ser Asp Thr Lys Tyr 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  41

Ile Ser Gly Ser Asp Gly Gly Thr 
1               5               


<210>  42
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  42

Ala Lys Asp Asn Tyr Ser Asp Cys Arg Gly Pro Tyr His Tyr 
1               5                   10                  


<210>  43
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  43

Ala Arg Asp Ser Leu Ser Gly Ser Gly Tyr Gly Cys Arg Gly Pro Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  44

Ala Ala Arg Arg Gly Ser Cys Ser Gly Ser Trp Thr Tyr 
1               5                   10              


<210>  45
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  45

Ala Ala Ala Leu Gly Arg Asp Cys Gln Gly Gly Gln Trp Lys Thr Ser 
1               5                   10                  15      


Ser 
    


<210>  46
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  46

Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly Arg Tyr 
1               5                   10              


<210>  47
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  47

Ala Thr Asp Arg Tyr Ser Asp Cys Arg Gly Pro Tyr Glu Asn 
1               5                   10                  


<210>  48
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  48

Ala Ala Asp Pro Tyr Gly Asp Cys Arg Gly Pro Tyr Asp Tyr 
1               5                   10                  


<210>  49
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  49

Ala Val Arg Arg Gly Tyr Gly Cys Ser Gly Pro Trp His Tyr 
1               5                   10                  


<210>  50
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  50

Ala Ala Ala Leu Gly Arg Asp Cys Gln Gly Gly Gln Trp Lys Thr Asp 
1               5                   10                  15      


Ser 
    


<210>  51
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  51

Ala Ala Ala Arg Lys Gly Ser Thr Asp Cys Gln Gly Ala Ile Trp Gly 
1               5                   10                  15      


Ser 
    


<210>  52
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  52

Ala Ala Asp Arg Trp Gln Thr Cys Thr Gly Pro Tyr Asp His 
1               5                   10                  


<210>  53
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  53

Ala Ala Arg Val Pro Asp Tyr Gly Asp Ile Thr Asp Cys Gly Gly Lys 
1               5                   10                  15      


Trp Asp Asp Tyr 
            20  


<210>  54
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  54

Ala Ala Arg Ser Gly Asp Gly Cys Asn Gly Arg Trp Asp Tyr 
1               5                   10                  


<210>  55
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  55

Ala Thr Pro Gly Ile His Gly Thr Ser Cys Asn Thr Ser Trp Lys Tyr 
1               5                   10                  15      


<210>  56
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  56

Ala Arg Ala Gln Ala Asp Arg Cys Leu Gly Gly Ile Trp Pro Thr Gly 
1               5                   10                  15      


Asp 
    


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4S linker

<400>  57

Gly Gly Gly Gly Ser 
1               5   


<210>  58
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  58

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Glu 
        35                  40                  45              


Ser Phe Ser Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
    50                  55                  60                  


Glu Leu Val Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr 
65                  70                  75                  80  


Tyr Thr Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly 
        115                 120                 125             


Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp 
                165                 170                 175     


Tyr Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
            180                 185                 190         


Gly Val Ser Cys Ile Arg Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Thr Lys Asn Thr 
    210                 215                 220                 


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Thr Asp Arg Tyr Ser Asp Cys Arg Gly Pro Tyr Glu Asn 
                245                 250                 255     


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


<210>  59
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  59

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu 
        35                  40                  45              


Asp Tyr Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Gly Val Ser Cys Ile Arg Ser Ser Asp Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Thr Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Thr Asp Arg Tyr Ser Asp Cys Arg Gly Pro Tyr Glu 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Glu Ser Phe 
                165                 170                 175     


Ser Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
            180                 185                 190         


Val Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr Tyr Thr 
        195                 200                 205             


Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Phe Cys Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly Arg Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


<210>  60
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  60

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Glu 
        35                  40                  45              


Ser Phe Ser Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
    50                  55                  60                  


Glu Leu Val Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr 
65                  70                  75                  80  


Tyr Thr Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly 
        115                 120                 125             


Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Phe Thr Leu Asp Tyr Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Glu Arg Glu Gly Val Ser Cys Ile Arg Ser Ser Asp Gly Ser 
        195                 200                 205             


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp 
    210                 215                 220                 


Asn Thr Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asp Arg Tyr Ser Asp Cys Arg 
                245                 250                 255     


Gly Pro Tyr Glu Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 270         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        275                 280                 285             


Pro Glu Leu Leu Gly 
    290             


<210>  61
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  61

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu 
        35                  40                  45              


Asp Tyr Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Gly Val Ser Cys Ile Arg Ser Ser Asp Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Thr Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Thr Asp Arg Tyr Ser Asp Cys Arg Gly Pro Tyr Glu 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                165                 170                 175     


Ser Ile Glu Ser Phe Ser Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly 
            180                 185                 190         


Lys Gln Arg Glu Leu Val Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser 
        195                 200                 205             


Phe Ser Thr Tyr Thr Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Phe Cys Asn Val Asp Pro Trp Ser Gln Ser 
                245                 250                 255     


Trp Pro Gly Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 270         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        275                 280                 285             


Pro Glu Leu Leu Gly 
    290             


<210>  62
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  62

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Glu 
        35                  40                  45              


Ser Phe Ser Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
    50                  55                  60                  


Glu Leu Val Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr 
65                  70                  75                  80  


Tyr Thr Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly 
        115                 120                 125             


Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Ala Ile Gly Trp 
            180                 185                 190         


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser Cys Ile Arg 
        195                 200                 205             


Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Ser Asp Asn Thr Lys Asn Thr Val Tyr Leu Gln Met Asn 
225                 230                 235                 240 


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asp Arg 
                245                 250                 255     


Tyr Ser Asp Cys Arg Gly Pro Tyr Glu Asn Trp Gly Gln Gly Thr Gln 
            260                 265                 270         


Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
        275                 280                 285             


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    290                 295             


<210>  63
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  63

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu 
        35                  40                  45              


Asp Tyr Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Gly Val Ser Cys Ile Arg Ser Ser Asp Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Thr Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Thr Asp Arg Tyr Ser Asp Cys Arg Gly Pro Tyr Glu 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Ser Ile Glu Ser Phe Ser Phe Met Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Gly Phe Thr Gly 
        195                 200                 205             


Ala Ala Ser Leu Ser Phe Ser Thr Tyr Thr Asp Ala Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn Val Asp 
                245                 250                 255     


Pro Trp Ser Gln Ser Trp Pro Gly Arg Tyr Trp Gly Gln Gly Thr Gln 
            260                 265                 270         


Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
        275                 280                 285             


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    290                 295             


<210>  64
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  64

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Glu 
        35                  40                  45              


Ser Phe Ser Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
    50                  55                  60                  


Glu Leu Val Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr 
65                  70                  75                  80  


Tyr Thr Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly 
        115                 120                 125             


Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp 
                165                 170                 175     


Gly Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
            180                 185                 190         


Gly Leu Ala Cys Ile Ser Gly Ser Asp Gly Ser Thr His Tyr Leu Asp 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr 
    210                 215                 220                 


Met Ala Leu Gln Met Asn Ser Leu Gln Phe Gly Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Ala Arg Arg Gly Ser Cys Ser Gly Ser Trp Thr Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265     


<210>  65
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  65

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu 
        35                  40                  45              


Asp Gly Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Gly Leu Ala Cys Ile Ser Gly Ser Asp Gly Ser Thr His Tyr Leu 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn 
                85                  90                  95      


Thr Met Ala Leu Gln Met Asn Ser Leu Gln Phe Gly Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Arg Arg Gly Ser Cys Ser Gly Ser Trp Thr Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Glu Ser Phe Ser 
                165                 170                 175     


Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
            180                 185                 190         


Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr Tyr Thr Asp 
        195                 200                 205             


Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
    210                 215                 220                 


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Phe Cys Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly Arg Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285         


<210>  66
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  66

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Glu 
        35                  40                  45              


Ser Phe Ser Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
    50                  55                  60                  


Glu Leu Val Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr 
65                  70                  75                  80  


Tyr Thr Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly 
        115                 120                 125             


Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gln Leu Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Leu Thr Leu Asp Gly Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Glu Arg Glu Gly Leu Ala Cys Ile Ser Gly Ser Asp Gly Ser 
        195                 200                 205             


Thr His Tyr Leu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 


Asn Gly Lys Asn Thr Met Ala Leu Gln Met Asn Ser Leu Gln Phe Gly 
225                 230                 235                 240 


Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Arg Arg Gly Ser Cys Ser Gly 
                245                 250                 255     


Ser Trp Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu 
            260                 265                 270         


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        275                 280                 285             


Glu Leu Leu Gly 
    290         


<210>  67
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  67

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu 
        35                  40                  45              


Asp Gly Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Gly Leu Ala Cys Ile Ser Gly Ser Asp Gly Ser Thr His Tyr Leu 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn 
                85                  90                  95      


Thr Met Ala Leu Gln Met Asn Ser Leu Gln Phe Gly Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Arg Arg Gly Ser Cys Ser Gly Ser Trp Thr Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser 
                165                 170                 175     


Ile Glu Ser Phe Ser Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gln Arg Glu Leu Val Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe 
        195                 200                 205             


Ser Thr Tyr Thr Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Phe Cys Asn Val Asp Pro Trp Ser Gln Ser Trp 
                245                 250                 255     


Pro Gly Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu 
            260                 265                 270         


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        275                 280                 285             


Glu Leu Leu Gly 
    290         


<210>  68
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  68

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Glu 
        35                  40                  45              


Ser Phe Ser Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
    50                  55                  60                  


Glu Leu Val Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr 
65                  70                  75                  80  


Tyr Thr Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly 
        115                 120                 125             


Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Gly Tyr Ala Ile Gly Trp 
            180                 185                 190         


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Leu Ala Cys Ile Ser 
        195                 200                 205             


Gly Ser Asp Gly Ser Thr His Tyr Leu Asp Ser Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Met Ala Leu Gln Met Asn 
225                 230                 235                 240 


Ser Leu Gln Phe Gly Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Arg Arg 
                245                 250                 255     


Gly Ser Cys Ser Gly Ser Trp Thr Tyr Trp Gly Gln Gly Thr Gln Val 
            260                 265                 270         


Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
        275                 280                 285             


Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    290                 295         


<210>  69
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  69

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu 
        35                  40                  45              


Asp Gly Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Gly Leu Ala Cys Ile Ser Gly Ser Asp Gly Ser Thr His Tyr Leu 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn 
                85                  90                  95      


Thr Met Ala Leu Gln Met Asn Ser Leu Gln Phe Gly Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Arg Arg Gly Ser Cys Ser Gly Ser Trp Thr Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Glu Ser Phe Ser Phe Met Gly Trp Tyr Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Gly Phe Thr Gly Ala 
        195                 200                 205             


Ala Ser Leu Ser Phe Ser Thr Tyr Thr Asp Ala Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn 
225                 230                 235                 240 


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn Val Asp Pro 
                245                 250                 255     


Trp Ser Gln Ser Trp Pro Gly Arg Tyr Trp Gly Gln Gly Thr Gln Val 
            260                 265                 270         


Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
        275                 280                 285             


Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    290                 295         


<210>  70
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  70

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Glu 
        35                  40                  45              


Ser Phe Ser Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
    50                  55                  60                  


Glu Leu Val Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr 
65                  70                  75                  80  


Tyr Thr Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly 
        115                 120                 125             


Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Thr 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe Asp 
                165                 170                 175     


Asp Thr Ala Thr Gly Trp Phe Arg Gln Ala Pro Gly Lys Asn Arg Glu 
            180                 185                 190         


Gly Val Ala Cys Ile Ser Ser Ser Asp Gly Arg Ile His Tyr Ile Asp 
        195                 200                 205             


Ser Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Lys Thr 
    210                 215                 220                 


Val Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Ala Ala Arg Lys Gly Ser Thr Asp Cys Gln Gly Ala Ile 
                245                 250                 255     


Trp Gly Ser Trp Gly Gln Gly Thr Gln Val Ile Val Ser Ser Glu Pro 
            260                 265                 270         


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Leu Leu Gly 
    290     


<210>  71
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  71

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln 
            20                  25                  30          


Thr Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe 
        35                  40                  45              


Asp Asp Thr Ala Thr Gly Trp Phe Arg Gln Ala Pro Gly Lys Asn Arg 
    50                  55                  60                  


Glu Gly Val Ala Cys Ile Ser Ser Ser Asp Gly Arg Ile His Tyr Ile 
65                  70                  75                  80  


Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Lys 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Ala Arg Lys Gly Ser Thr Asp Cys Gln Gly Ala 
        115                 120                 125             


Ile Trp Gly Ser Trp Gly Gln Gly Thr Gln Val Ile Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
                165                 170                 175     


Glu Ser Phe Ser Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln 
            180                 185                 190         


Arg Glu Leu Val Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser 
        195                 200                 205             


Thr Tyr Thr Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Phe Cys Asn Val Asp Pro Trp Ser Gln Ser Trp Pro 
                245                 250                 255     


Gly Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro 
            260                 265                 270         


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Leu Leu Gly 
    290     


<210>  72
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  72

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Glu 
        35                  40                  45              


Ser Phe Ser Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
    50                  55                  60                  


Glu Leu Val Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr 
65                  70                  75                  80  


Tyr Thr Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly 
        115                 120                 125             


Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gln Leu Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Ala Gln Thr Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ala 
                165                 170                 175     


Gly Phe Thr Phe Asp Asp Thr Ala Thr Gly Trp Phe Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Asn Arg Glu Gly Val Ala Cys Ile Ser Ser Ser Asp Gly Arg 
        195                 200                 205             


Ile His Tyr Ile Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp 
    210                 215                 220                 


Asn Ala Lys Lys Thr Val Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Arg Lys Gly Ser Thr Asp 
                245                 250                 255     


Cys Gln Gly Ala Ile Trp Gly Ser Trp Gly Gln Gly Thr Gln Val Ile 
            260                 265                 270         


Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
        275                 280                 285             


Cys Pro Ala Pro Glu Leu Leu Gly 
    290                 295     


<210>  73
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  73

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln 
            20                  25                  30          


Thr Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe 
        35                  40                  45              


Asp Asp Thr Ala Thr Gly Trp Phe Arg Gln Ala Pro Gly Lys Asn Arg 
    50                  55                  60                  


Glu Gly Val Ala Cys Ile Ser Ser Ser Asp Gly Arg Ile His Tyr Ile 
65                  70                  75                  80  


Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Lys 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Ala Arg Lys Gly Ser Thr Asp Cys Gln Gly Ala 
        115                 120                 125             


Ile Trp Gly Ser Trp Gly Gln Gly Thr Gln Val Ile Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Ser Ile Glu Ser Phe Ser Phe Met Gly Trp Tyr Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Gly Phe Thr Gly Ala Ala 
        195                 200                 205             


Ser Leu Ser Phe Ser Thr Tyr Thr Asp Ala Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn Val Asp Pro Trp 
                245                 250                 255     


Ser Gln Ser Trp Pro Gly Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            260                 265                 270         


Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
        275                 280                 285             


Cys Pro Ala Pro Glu Leu Leu Gly 
    290                 295     


<210>  74
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  74

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Glu 
        35                  40                  45              


Ser Phe Ser Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
    50                  55                  60                  


Glu Leu Val Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr 
65                  70                  75                  80  


Tyr Thr Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly 
        115                 120                 125             


Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Ala Gln Thr Gly Gly Ser Leu Arg Leu 
                165                 170                 175     


Ser Cys Ala Ala Ala Gly Phe Thr Phe Asp Asp Thr Ala Thr Gly Trp 
            180                 185                 190         


Phe Arg Gln Ala Pro Gly Lys Asn Arg Glu Gly Val Ala Cys Ile Ser 
        195                 200                 205             


Ser Ser Asp Gly Arg Ile His Tyr Ile Asp Ser Ala Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Lys Asp Asn Ala Lys Lys Thr Val Tyr Leu Gln Met Asp 
225                 230                 235                 240 


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Arg 
                245                 250                 255     


Lys Gly Ser Thr Asp Cys Gln Gly Ala Ile Trp Gly Ser Trp Gly Gln 
            260                 265                 270         


Gly Thr Gln Val Ile Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr 
        275                 280                 285             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    290                 295                 300     


<210>  75
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  75

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln 
            20                  25                  30          


Thr Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe 
        35                  40                  45              


Asp Asp Thr Ala Thr Gly Trp Phe Arg Gln Ala Pro Gly Lys Asn Arg 
    50                  55                  60                  


Glu Gly Val Ala Cys Ile Ser Ser Ser Asp Gly Arg Ile His Tyr Ile 
65                  70                  75                  80  


Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Lys 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Ala Arg Lys Gly Ser Thr Asp Cys Gln Gly Ala 
        115                 120                 125             


Ile Trp Gly Ser Trp Gly Gln Gly Thr Gln Val Ile Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu 
145                 150                 155                 160 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu 
                165                 170                 175     


Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Glu Ser Phe Ser Phe Met 
            180                 185                 190         


Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Gly 
        195                 200                 205             


Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr Tyr Thr Asp Ala Val 
    210                 215                 220                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
225                 230                 235                 240 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                245                 250                 255     


Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly Arg Tyr Trp Gly Gln 
            260                 265                 270         


Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr 
        275                 280                 285             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    290                 295                 300     


<210>  76
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb fusion

<400>  76

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Glu 
        35                  40                  45              


Ser Phe Ser Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
    50                  55                  60                  


Glu Leu Val Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr 
65                  70                  75                  80  


Tyr Thr Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly 
        115                 120                 125             


Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys 
    130                 135                 140                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
145                 150                 155                 160 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                165                 170                 175     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            180                 185                 190         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        195                 200                 205             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser 
    210                 215                 220                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
225                 230                 235                 240 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                245                 250                 255     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            260                 265                 270         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        275                 280                 285             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    290                 295                 300                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
305                 310                 315                 320 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                325                 330                 335     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            340                 345                 350         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        355                 360                 365             


Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 
    370                 375                 380                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
385                 390                 395                 400 


Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Ala Ile Gly Trp Phe Arg 
                405                 410                 415     


Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser Cys Ile Arg Ser Ser 
            420                 425                 430         


Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        435                 440                 445             


Ser Ser Asp Asn Thr Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
    450                 455                 460                 


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asp Arg Tyr Ser 
465                 470                 475                 480 


Asp Cys Arg Gly Pro Tyr Glu Asn Trp Gly Gln Gly Thr Gln Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210>  77
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of the BMS antibody

<400>  77

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Arg Gly Ser Thr Asn Ser Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Leu Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Phe Gly Tyr Ser Asp Tyr Glu Tyr Asn Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  78
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of the BMS antibody

<400>  78

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Asn Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  79
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS2-2 antibody

<400>  79

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Ser Gln Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile His Trp Thr Ser Ser Val Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Tyr Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr His Tyr Tyr Thr His Arg Gly Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  80
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17-H1 sdAb

<400>  80

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Ala Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Leu 
        35                  40                  45              


Ala Cys Ile Ser Gly Ser Asp Gly Ser Thr His Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Met Ala 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Phe Gly Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Gly Ser Cys Ser Gly Ser Trp Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  81
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17-H2 sdAb

<400>  81

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Glu Gly Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Leu 
        35                  40                  45              


Ala Cys Ile Ser Gly Ser Asp Gly Ser Thr His Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Met Ala 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Phe Gly Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Gly Ser Cys Ser Gly Ser Trp Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  82
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17-H3 sdAb

<400>  82

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Gly Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Leu 
        35                  40                  45              


Ala Cys Ile Ser Gly Ser Asp Ala Ser Thr His Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Met Ala 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Phe Gly Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Gly Ser Cys Ser Gly Ser Trp Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  83
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17-H4 sdAb

<400>  83

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Gly Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Leu 
        35                  40                  45              


Ala Cys Ile Ser Gly Ser Glu Gly Ser Thr His Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Met Ala 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Phe Gly Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Gly Ser Cys Ser Gly Ser Trp Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  84
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17-H5 sdAb

<400>  84

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Ala Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Leu 
        35                  40                  45              


Ala Cys Ile Ser Gly Ser Asp Ala Ser Thr His Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Met Ala 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Phe Gly Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Gly Ser Cys Ser Gly Ser Trp Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  85
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  27-H1

<400>  85

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Ser Ser Asp Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Thr Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Tyr Ser Asp Cys Arg Gly Pro Tyr Glu Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  86
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  27-H2 sdAb

<400>  86

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Ser Ser Glu Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Thr Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Tyr Ser Asp Cys Arg Gly Pro Tyr Glu Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  87
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KN035 HC

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  88
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KN035 LC

<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  89
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17-H5B1 sdAb

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Ala Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Cys Ile Ser Gly Ser Asp Ala Ser Thr His Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Gly Ser Cys Ser Gly Ser Trp Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  90
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17-H5B2 sdAb

<400>  90

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Ala Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Cys Ile Ser Gly Ser Asp Ala Ser Thr His Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Gly Ser Cys Ser Gly Ser Trp Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  91
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17-H5B3 sdAb

<400>  91

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Ala Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Leu 
        35                  40                  45              


Ala Cys Ile Ser Gly Ser Asp Ala Ser Thr His Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Gly Ser Cys Ser Gly Ser Trp Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  92
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  25-B5 sdAb

<400>  92

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Glu Ser Phe Ser 
            20                  25                  30          


Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr Tyr Thr Asp 
    50                  55                  60                  


Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly Arg Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  93
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  25-B6 sdAb

<400>  93

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Glu Ser Phe Ser 
            20                  25                  30          


Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr Tyr Thr Asp 
    50                  55                  60                  


Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly Arg Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  94
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  25-B7 sdAb

<400>  94

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Glu Ser Phe Ser 
            20                  25                  30          


Phe Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr Tyr Thr Asp 
    50                  55                  60                  


Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Asn Val Asp Pro Trp Ser Gln Ser Trp Pro Gly Arg Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  95
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  27-H1B1 sdAb

<400>  95

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ser Cys Ile Arg Ser Ser Asp Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Tyr Ser Asp Cys Arg Gly Pro Tyr Glu Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  96
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  27-H1B2

<400>  96

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ser Cys Ile Arg Ser Ser Asp Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Tyr Ser Asp Cys Arg Gly Pro Tyr Glu Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  97
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  27-H1B3 sdAb

<400>  97

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Ser Ser Asp Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Tyr Ser Asp Cys Arg Gly Pro Tyr Glu Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  98

Gly Leu Thr Leu Asp Gly Tyr Ala Ile Gly 
1               5                   10  


<210>  99
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  99

Gly Leu Thr Leu Asp Ala Tyr Ala Ile Gly 
1               5                   10  


<210>  100
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  100

Gly Leu Thr Leu Glu Gly Tyr Ala Ile Gly 
1               5                   10  


<210>  101
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  101

Gly Phe Thr Leu Asp Tyr Tyr Ala Ile Gly 
1               5                   10  


<210>  102
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  102

Cys Ile Ser Gly Ser Asp Gly Ser Thr His Tyr Leu Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  103

Cys Ile Ser Gly Ser Asp Ala Ser Thr His Tyr Leu Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  104
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  104

Cys Ile Ser Gly Ser Glu Gly Ser Thr His Tyr Leu Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  105
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  105

Cys Ile Arg Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  106
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  106

Cys Ile Arg Ser Ser Asp Ala Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  107
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  107

Cys Ile Arg Ser Ser Glu Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  108
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  108

Arg Arg Gly Ser Cys Ser Gly Ser Trp Thr Tyr 
1               5                   10      


<210>  109
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  109

Asp Arg Tyr Ser Asp Cys Arg Gly Pro Tyr Glu Asn 
1               5                   10          


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  110

Gly Ser Ile Glu Ser Phe Ser Phe Met Gly 
1               5                   10  


<210>  111
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  111

Gly Phe Thr Gly Ala Ala Ser Leu Ser Phe Ser Thr Tyr Thr Asp Ala 
1               5                   10                  15      


Val Lys Gly 
            


<210>  112
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  112

Asp Pro Trp Ser Gln Ser Trp Pro Gly Arg Tyr 
1               5                   10      




