                         SEQUENCE LISTING

<110>  Ϻ＼޹˾
 
<120>  RasͻλļʶRasͻTϸ

<130>  IEC210307PCT

<150>  PCT/CN2020/131149
<151>  2020-11-24

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  188
<212>  PRT
<213>  ˹

<220>
<223>  RAS G12Vͻ就

<400>  1

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  2
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  RAS G12Vͻ就aa3-13/G12V-T9

<400>  2

Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly 
1               5                   10      


<210>  3
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  RAS G12Vͻ就aa2-13/G12V-T3

<400>  3

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly 
1               5                   10          


<210>  4
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  RAS G12Vͻ就aa3-14/G12V-T16

<400>  4

Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val 
1               5                   10          


<210>  5
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  RAS G12Vͻ就aa2-14/G12V-T15

<400>  5

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val 
1               5                   10              


<210>  6
<211>  134
<212>  PRT
<213>  ˹

<220>
<223>  B13.14.1 TCR V(alpha)

<400>  6

Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Asp Gly Arg Gly Gly Gly Asn Lys Leu Thr Phe Gly Thr Gly Thr 
        115                 120                 125             


Gln Leu Lys Val Glu Leu 
    130                 


<210>  7
<211>  133
<212>  PRT
<213>  ˹

<220>
<223>  B13.14.1 TCR V(beta)

<400>  7

Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Pro Gly Gln Arg Asp Asn Ser Pro Leu His Phe Gly Asn Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Thr 
    130             


<210>  8
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  B13.14.1 TCR CDR1(alpha)

<400>  8

Val Ser Gly Asn Pro Tyr 
1               5       


<210>  9
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  B13.14.1 TCR CDR2(alpha)

<400>  9

Tyr Ile Thr Gly Asp Asn Leu Val 
1               5               


<210>  10
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  B13.14.1 TCR CDR3(alpha)

<400>  10

Ala Val Arg Asp Gly Arg Gly Gly Gly Asn Lys Leu Thr 
1               5                   10              


<210>  11
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  B13.14.1 TCR CDR1(beta)

<400>  11

Leu Asn His Asp Ala 
1               5   


<210>  12
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  B13.14.1 TCR CDR2(beta)

<400>  12

Ser Gln Ile Val Asn Asp 
1               5       


<210>  13
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  B13.14.1 TCR CDR3(beta)

<400>  13

Ala Ser Ser Pro Gly Gln Arg Asp Asn Ser Pro Leu His 
1               5                   10              


<210>  14
<211>  2012
<212>  DNA
<213>  ˹

<220>
<223>  Ras G12V-mRNA

<400>  14
cttgttcttt ttgcagaagc tcagaataaa cgctcaactt tgggccacca tgccccggca       60

gctcagcgcg gcggccgcgc tcttcgcgtc cctggccgta attttgcacg atggcagtca      120

aatgagagca aaagcatttc cagaaaccag agattattct caacctactg cagcagcaac      180

agtacaggac ataaaaaaac ctgtccagca accagctaag caagcacctc accaaacttt      240

agcagcaaga ttcatggatg gtcatatcac ctttcaaaca gcggccacag taaaaattcc      300

aacaactacc ccagcgacta caaaaaacac tgcaaccacc agcccaatta cctacaccct      360

ggtcacaacc caggccacac ccaacaactc acacacagct cctccagtta ctgaagttac      420

agtcggccct agcttagccc cttattcact gccacccacc atcaccccac cagctcatac      480

aactggaacc agttcatcaa ccgtcagcca cacaactggg aacaccactc aacccagtaa      540

ccagaccacc cttccagcaa ctttatcgat agcactgcac aaaagcacaa ccggtcagaa      600

gcctgttcaa cccacccatg ccccaggaac aacggcagct gcccacaata ccacccgcac      660

agctgcacct gcctccacgg ttcctgggcc cacccttgca cctcagccat cgtcagtcaa      720

gactggaatt tatcaggttc taaacggaag cagactctgt ataaaagcag agatggggat      780

acagctgatt gttcaagaca aggagtcggt tttttcacct cggagatact tcaacatcga      840

ccccaacgca acgcaagcct ctgggaactg tggcacccga aaatccaacc ttctgttgaa      900

ttttcagggc ggatttgtga atctcacatt taccaaggat gaagaatcat attatatcag      960

tgaagtggga gcctatttga ccgtctcaga tccagagaca atttaccaag gaatcaaaca     1020

tgcggtggtg atgttccaga cagcagtcgg gcattccttc aagtgcgtga gtgaacagag     1080

cctccagttg tcagcccacc tgcaggtgaa aacaaccgat gtccaacttc aagcctttga     1140

ttttgaagat gaccactttg gaaatgtgga tgagtgctcg tctgactaca caactgaata     1200

taaacttgtg gtagttggag ctgttggcgt aggcaagagt gccttgacga tacagctaat     1260

tcagaatcat tttgtggacg aatatgatcc aacaatagag gattcctaca ggaagcaagt     1320

agtaattgat ggagaaacct gtctcttgga tattctcgac acagcaggtc aagaggagta     1380

cagtgcaatg agggaccagt acatgaggac tggggagggc tttctttgtg tatttgccat     1440

aaataatact aaatcatttg aagatattca ccattataga gaacaaatta aaagagttaa     1500

ggactctgaa gatgtaccta tggtcctagt aggaaataaa tgtgatttgc cttctagaac     1560

agtagacaca aaacaggctc aggacttagc aagaagttat ggaattcctt ttattgaaac     1620

atcagcaaag acaagacagg gtgttgatga tgccttctat acattagttc gagaaattcg     1680

aaaacataaa gaaaagatga gcaaagatgg taaaaagaag aaaaagaagt caaagacaaa     1740

gtgtgtaatt atgattgtgc ttcctgtgat tggggccatc gtggttggtc tctgccttat     1800

gggtatgggt gtctataaaa tccgcctaag gtgtcaatca tctggatacc agagaatcta     1860

atcctctaga ggatctggtt accactaaac cagcctcaag aacacccgaa tggagtctct     1920

aagctacata ataccaactt acacttacaa aatgttgtcc cccaaaatgt agccattcgt     1980

atctgctcct aataaaaaga aagtttcttc ac                                   2012


<210>  15
<211>  402
<212>  DNA
<213>  ˹

<220>
<223>  B13.14.1 TCR V(alpha)

<400>  15
atggcctctg cacccatctc gatgcttgcg atgctcttca cattgagtgg gctgagagct       60

cagtcagtgg ctcagccgga agatcaggtc aacgttgctg aagggaatcc tctgactgtg      120

aaatgcacct attcagtctc tggaaaccct tatctttttt ggtatgttca ataccccaac      180

cgaggcctcc agttccttct gaaatacatc acaggggata acctggttaa aggcagctat      240

ggctttgaag ctgaatttaa caagagccaa acctccttcc acctgaagaa accatctgcc      300

cttgtgagcg actccgcttt gtacttctgt gctgtgagag acggtagggg aggaggaaac      360

aaactcacct ttgggacagg cactcagcta aaagtggaac tc                         402


<210>  16
<211>  399
<212>  DNA
<213>  ˹

<220>
<223>  B13.14.1 TCR V(beta)

<400>  16
atgagcaacc aggtgctctg ctgtgtggtc ctttgtctcc tgggagcaaa caccgtggat       60

ggtggaatca ctcagtcccc aaagtacctg ttcagaaagg aaggacagaa tgtgaccctg      120

agttgtgaac agaatttgaa ccacgatgcc atgtactggt accgacagga cccagggcaa      180

gggctgagat tgatctacta ctcacagata gtaaatgact ttcagaaagg agatatagct      240

gaagggtaca gcgtctctcg ggagaagaag gaatcctttc ctctcactgt gacatcggcc      300

caaaagaacc cgacagcttt ctatctctgt gccagtagcc ccggacaacg agataattca      360

cccctccact ttgggaacgg gaccaggctc actgtgaca                             399


<210>  17
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  Ras WT-T15

<400>  17

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val 
1               5                   10              


<210>  18
<211>  137
<212>  PRT
<213>  ˹

<220>
<223>  TCR(alpha)㶨

<400>  18

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser 
            100                 105                 110         


Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  19
<211>  411
<212>  DNA
<213>  ˹

<220>
<223>  TCR(alpha)㶨

<400>  19
gacatccaga acccagaacc tgctgtgtac cagttaaaag atcctcggtc tcaggacagc       60

accctctgcc tgttcaccga ctttgactcc caaatcaatg tgccgaaaac catggaatct      120

ggaacgttca tcactgacaa aactgtgctg gacatgaaag ctatggattc caagagcaat      180

ggggccattg cctggagcaa ccagacaagc ttcacctgcc aagatatctt caaagagacc      240

aacgccacct accccagttc agacgttccc tgtgatgcca cgttgactga gaaaagcttt      300

gaaacagata tgaacctaaa ctttcaaaac ctgtcagtta tgggactccg aatcctcctg      360

ctgaaagtag ccggatttaa cctgctcatg acgctgaggc tgtggtccag t               411


<210>  20
<211>  173
<212>  PRT
<213>  ˹

<220>
<223>  TCR(beta)㶨

<400>  20

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  21
<211>  519
<212>  DNA
<213>  ˹

<220>
<223>  TCR(beta)㶨

<400>  21
gaggacctgc gcaacgtcac cccaccaaag gtcagtttgt ttgagccatc aaaggcggag       60

atcgccaaca aacagaaagc tacgctcgtg tgtttggctc ggggcttctt cccagaccac      120

gtagaacttt cctggtgggt caatggaaag gaggttcatt ccggagtgtc cactgatccc      180

caagcgtaca aggaatccaa ctatagctac tgtctctcat ctcggctccg ggtgagtgcg      240

acattctggc ataatcctcg gaaccacttt cgatgccaag tgcagtttca tgggttgagc      300

gaggaagaca agtggcccga gggcagtcct aaaccagtca ctcaaaacat aagcgccgag      360

gcatggggta gagccgattg tgggattact agcgcttcat accaacaagg ggtattgagc      420

gctacaattc tttacgaaat tctcctcggc aaggcgacgc tctacgccgt actggtgtct      480

actctcgtgg ttatggcaat ggtgaaacgg aaaaacagc                             519


<210>  22
<211>  57
<212>  DNA
<213>  ˹

<220>
<223>  P2A

<400>  22
gccaccaact tcagcctgct gaagcaggcc ggcgacgtgg aggagaaccc cggcccc          57


<210>  23
<211>  813
<212>  DNA
<213>  ˹

<220>
<223>  B13.14.1/TRAV+mCa

<400>  23
atggcctctg cacccatctc gatgcttgcg atgctcttca cattgagtgg gctgagagct       60

cagtcagtgg ctcagccgga agatcaggtc aacgttgctg aagggaatcc tctgactgtg      120

aaatgcacct attcagtctc tggaaaccct tatctttttt ggtatgttca ataccccaac      180

cgaggcctcc agttccttct gaaatacatc acaggggata acctggttaa aggcagctat      240

ggctttgaag ctgaatttaa caagagccaa acctccttcc acctgaagaa accatctgcc      300

cttgtgagcg actccgcttt gtacttctgt gctgtgagag acggtagggg aggaggaaac      360

aaactcacct ttgggacagg cactcagcta aaagtggaac tcgacatcca gaacccagaa      420

cctgctgtgt accagttaaa agatcctcgg tctcaggaca gcaccctctg cctgttcacc      480

gactttgact cccaaatcaa tgtgccgaaa accatggaat ctggaacgtt catcactgac      540

aaaactgtgc tggacatgaa agctatggat tccaagagca atggggccat tgcctggagc      600

aaccagacaa gcttcacctg ccaagatatc ttcaaagaga ccaacgccac ctaccccagt      660

tcagacgttc cctgtgatgc cacgttgact gagaaaagct ttgaaacaga tatgaaccta      720

aactttcaaa acctgtcagt tatgggactc cgaatcctcc tgctgaaagt agccggattt      780

aacctgctca tgacgctgag gctgtggtcc agt                                   813


<210>  24
<211>  918
<212>  DNA
<213>  ˹

<220>
<223>  B13.14.1/TRBV+mCb

<400>  24
atgagcaacc aggtgctctg ctgtgtggtc ctttgtctcc tgggagcaaa caccgtggat       60

ggtggaatca ctcagtcccc aaagtacctg ttcagaaagg aaggacagaa tgtgaccctg      120

agttgtgaac agaatttgaa ccacgatgcc atgtactggt accgacagga cccagggcaa      180

gggctgagat tgatctacta ctcacagata gtaaatgact ttcagaaagg agatatagct      240

gaagggtaca gcgtctctcg ggagaagaag gaatcctttc ctctcactgt gacatcggcc      300

caaaagaacc cgacagcttt ctatctctgt gccagtagcc ccggacaacg agataattca      360

cccctccact ttgggaacgg gaccaggctc actgtgacag aggacctgcg caacgtcacc      420

ccaccaaagg tcagtttgtt tgagccatca aaggcggaga tcgccaacaa acagaaagct      480

acgctcgtgt gtttggctcg gggcttcttc ccagaccacg tagaactttc ctggtgggtc      540

aatggaaagg aggttcattc cggagtgtcc actgatcccc aagcgtacaa ggaatccaac      600

tatagctact gtctctcatc tcggctccgg gtgagtgcga cattctggca taatcctcgg      660

aaccactttc gatgccaagt gcagtttcat gggttgagcg aggaagacaa gtggcccgag      720

ggcagtccta aaccagtcac tcaaaacata agcgccgagg catggggtag agccgattgt      780

gggattacta gcgcttcata ccaacaaggg gtattgagcg ctacaattct ttacgaaatt      840

ctcctcggca aggcgacgct ctacgccgta ctggtgtcta ctctcgtggt tatggcaatg      900

gtgaaacgga aaaacagc                                                    918


<210>  25
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  TCR CDR3(alpha)ͨʽ


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa ѡG, A, D, L, M, Q, R, S, V, W, Y

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa ѡR, A, D, G, H, I, K, L, M, N, P, Q, S, T, V, W, Y

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  XaaѡG, A, D, E, F, H, I, K, L, M, N, P, Q, R, S, T, V, W, Y

<400>  25

Ala Val Arg Asp Xaa Xaa Xaa Gly Gly Asn Lys Leu Thr 
1               5                   10              


<210>  26
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  TCR CDR3(beta)ͨʽ


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa ѡP, A, H, M, S, T, V, Y

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa ѡQS

<400>  26

Ala Ser Ser Xaa Gly Xaa Arg Asp Asn Ser Pro Leu His 
1               5                   10              


<210>  27
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  TCR CDR1(alpha)ͨʽ


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  XaaѡN, A, D, E, F, G, H, I, K, L, M, P, Q, R, S, T, V, W, Y

<400>  27

Val Ser Gly Xaa Pro Tyr 
1               5       


<210>  28
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  TCR CDR2(alpha)ͨʽ


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa ѡI, A, D, E, F, G, H, K, L, M, N, P, Q, R, S, T, V, W, Y

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  XaaѡT, A, D, E, H, I, L, N, Q, R, S, W, Y

<400>  28

Tyr Xaa Xaa Gly Asp Asn Leu Val 
1               5               


<210>  29
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  TCR CDR2(beta)ͨʽ


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  XaaѡQ, A, F, G, H, I, K, L, M, N, P, R, S, T, V, W, Y

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  XaaѡI, F, H, T, V

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  XaaѡD, A, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, Y

<400>  29

Ser Xaa Xaa Val Asn Xaa 
1               5       


<210>  30
<211>  45
<212>  PRT
<213>  ˹

<220>
<223>  B13.14.1 TCR FR1(alpha)

<400>  30

Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser 
        35                  40                  45  


<210>  31
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  B13.14.1 TCR FR2(alpha)

<400>  31

Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
1               5                   10                  15      


Lys 
    


<210>  32
<211>  34
<212>  PRT
<213>  ˹

<220>
<223>  B13.14.1 TCR FR3(alpha)

<400>  32

Lys Gly Ser Tyr Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser 
1               5                   10                  15      


Phe His Leu Lys Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr 
            20                  25                  30          


Phe Cys 
        


<210>  33
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  B13.14.1 TCR FR4(alpha)

<400>  33

Phe Gly Thr Gly Thr Gln Leu Lys Val Glu Leu 
1               5                   10      


<210>  34
<211>  45
<212>  PRT
<213>  ˹

<220>
<223>  B13.14.1 TCR FR1(beta)

<400>  34

Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn 
        35                  40                  45  


<210>  35
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  B13.14.1 TCR FR2(beta)

<400>  35

Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu Ile Tyr 
1               5                   10                  15      


Tyr 
    


<210>  36
<211>  37
<212>  PRT
<213>  ˹

<220>
<223>  B13.14.1 TCR FR3(beta)

<400>  36

Phe Gln Lys Gly Asp Ile Ala Glu Gly Tyr Ser Val Ser Arg Glu Lys 
1               5                   10                  15      


Lys Glu Ser Phe Pro Leu Thr Val Thr Ser Ala Gln Lys Asn Pro Thr 
            20                  25                  30          


Ala Phe Tyr Leu Cys 
        35          


<210>  37
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  B13.14.1 TCR FR4(beta)

<400>  37

Phe Gly Asn Gly Thr Arg Leu Thr Val Thr 
1               5                   10  


<210>  38
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  TCR FR2(alpha)ͨʽ


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa ѡK, A, D, E, F, G, H, I, L, M, N, P, Q, R, S, T, V, W, Y

<400>  38

Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu 
1               5                   10                  15      


Xaa 
    


<210>  39
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  TCR FR2(beta)ͨʽ


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  XaaѡY, A, E, F, I, K, L, M, N, P, Q, R, S, T, V, W

<400>  39

Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu Ile Tyr 
1               5                   10                  15      


Xaa 
    


<210>  40
<211>  37
<212>  PRT
<213>  ˹

<220>
<223>  TCR FR3(beta)ͨʽ


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  XaaѡQ, A, D, E, F, G, H, I, K, L, M, N, P, R, S, T, V, W, Y

<400>  40

Phe Xaa Lys Gly Asp Ile Ala Glu Gly Tyr Ser Val Ser Arg Glu Lys 
1               5                   10                  15      


Lys Glu Ser Phe Pro Leu Thr Val Thr Ser Ala Gln Lys Asn Pro Thr 
            20                  25                  30          


Ala Phe Tyr Leu Cys 
        35          


<210>  41
<211>  23
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T1

<400>  41

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys Ser 
1               5                   10                  15      


Ala Leu Thr Ile Gln Leu Ile 
            20              


<210>  42
<211>  14
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T2

<400>  42

Ala Val Gly Val Gly Lys Ser Ala Leu Thr Ile Gln Leu Ile 
1               5                   10                  


<210>  43
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T4

<400>  43

Val Val Val Gly Ala Val Gly Val Gly Lys Ser 
1               5                   10      


<210>  44
<211>  14
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T5

<400>  44

Val Gly Ala Val Gly Val Gly Lys Ser Ala Leu Thr Ile Gln 
1               5                   10                  


<210>  45
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T6

<400>  45

Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly 
1               5                   10          


<210>  46
<211>  14
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T7

<400>  46

Val Val Val Gly Ala Val Gly Val Gly Lys Ser Ala Leu Thr 
1               5                   10                  


<210>  47
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T8

<400>  47

Leu Val Val Val Gly Ala Val Gly Val Gly Lys Ser 
1               5                   10          


<210>  48
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T10

<400>  48

Tyr Lys Leu Val Val Val Gly Ala Val Gly 
1               5                   10  


<210>  49
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T11

<400>  49

Lys Leu Val Val Val Gly Ala Val Gly 
1               5                   


<210>  50
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T12

<400>  50

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val 
1               5                   10      


<210>  51
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T13

<400>  51

Glu Tyr Lys Leu Val Val Val Gly Ala Val 
1               5                   10  


<210>  52
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T14

<400>  52

Tyr Lys Leu Val Val Val Gly Ala Val 
1               5                   


<210>  53
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T17

<400>  53

Tyr Lys Leu Val Val Val Gly Ala Val Gly Val 
1               5                   10      


<210>  54
<211>  14
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T18

<400>  54

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly 
1               5                   10                  


<210>  55
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T19

<400>  55

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys 
1               5                   10                  15  


<210>  56
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T20

<400>  56

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys Ser 
1               5                   10                  15      


<210>  57
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T21

<400>  57

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys Ser 
1               5                   10                  15      


Ala 
    


<210>  58
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T15-A1

<400>  58

Ala Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val 
1               5                   10              


<210>  59
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T15-A2

<400>  59

Thr Ala Tyr Lys Leu Val Val Val Gly Ala Val Gly Val 
1               5                   10              


<210>  60
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T15-A3

<400>  60

Thr Glu Ala Lys Leu Val Val Val Gly Ala Val Gly Val 
1               5                   10              


<210>  61
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T15-A4

<400>  61

Thr Glu Tyr Ala Leu Val Val Val Gly Ala Val Gly Val 
1               5                   10              


<210>  62
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T15-A5

<400>  62

Thr Glu Tyr Lys Ala Val Val Val Gly Ala Val Gly Val 
1               5                   10              


<210>  63
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T15-A6

<400>  63

Thr Glu Tyr Lys Leu Ala Val Val Gly Ala Val Gly Val 
1               5                   10              


<210>  64
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T15-A7

<400>  64

Thr Glu Tyr Lys Leu Val Ala Val Gly Ala Val Gly Val 
1               5                   10              


<210>  65
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T15-A8

<400>  65

Thr Glu Tyr Lys Leu Val Val Ala Gly Ala Val Gly Val 
1               5                   10              


<210>  66
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T15-A9

<400>  66

Thr Glu Tyr Lys Leu Val Val Val Ala Ala Val Gly Val 
1               5                   10              


<210>  67
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T15-G10

<400>  67

Thr Glu Tyr Lys Leu Val Val Val Ala Gly Val Gly Val 
1               5                   10              


<210>  68
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T15-A12

<400>  68

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Ala Val 
1               5                   10              


<210>  69
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  G12V-T15-A13

<400>  69

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Ala 
1               5                   10              


