                         SEQUENCE LISTING

<110>  Health Research, Inc.
 
<120>  COMPOUNDS AND METHODS TO TARGET GLUCOSE-STIMULATED 
       PHOSPHOHISTIDINE SIGNALING AND ESOPHAGEAL CANCER GROWTH

<130>  003551.01012

<150>  63/117,432
<151>  2020-11-23

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAK segment

<400>  1

His Gly Asp Ala Thr Asp Val Arg Gly Ile Ile Gln Lys 
1               5                   10              


<210>  2
<211>  1052
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Ala Tyr Leu Asp Pro Asn Leu Asn His Thr Pro Asn Ser 
1               5                   10                  15      


Ser Thr Lys Thr His Leu Gly Thr Gly Met Glu Arg Ser Pro Gly Ala 
            20                  25                  30          


Met Glu Arg Val Leu Lys Val Phe His Tyr Phe Glu Ser Asn Ser Glu 
        35                  40                  45              


Pro Thr Thr Trp Ala Ser Ile Ile Arg His Gly Asp Ala Thr Asp Val 
    50                  55                  60                  


Arg Gly Ile Ile Gln Lys Ile Val Asp Ser His Lys Val Lys His Val 
65                  70                  75                  80  


Ala Cys Tyr Gly Phe Arg Leu Ser His Leu Arg Ser Glu Glu Val His 
                85                  90                  95      


Trp Leu His Val Asp Met Gly Val Ser Ser Val Arg Glu Lys Tyr Glu 
            100                 105                 110         


Leu Ala His Pro Pro Glu Glu Trp Lys Tyr Glu Leu Arg Ile Arg Tyr 
        115                 120                 125             


Leu Pro Lys Gly Phe Leu Asn Gln Phe Thr Glu Asp Lys Pro Thr Leu 
    130                 135                 140                 


Asn Phe Phe Tyr Gln Gln Val Lys Ser Asp Tyr Met Leu Glu Ile Ala 
145                 150                 155                 160 


Asp Gln Val Asp Gln Glu Ile Ala Leu Lys Leu Gly Cys Leu Glu Ile 
                165                 170                 175     


Arg Arg Ser Tyr Trp Glu Met Arg Gly Asn Ala Leu Glu Lys Lys Ser 
            180                 185                 190         


Asn Tyr Glu Val Leu Glu Lys Asp Val Gly Leu Lys Arg Phe Phe Pro 
        195                 200                 205             


Lys Ser Leu Leu Asp Ser Val Lys Ala Lys Thr Leu Arg Lys Leu Ile 
    210                 215                 220                 


Gln Gln Thr Phe Arg Gln Phe Ala Asn Leu Asn Arg Glu Glu Ser Ile 
225                 230                 235                 240 


Leu Lys Phe Phe Glu Ile Leu Ser Pro Val Tyr Arg Phe Asp Lys Glu 
                245                 250                 255     


Cys Phe Lys Cys Ala Leu Gly Ser Ser Trp Ile Ile Ser Val Glu Leu 
            260                 265                 270         


Ala Ile Gly Pro Glu Glu Gly Ile Ser Tyr Leu Thr Asp Lys Gly Cys 
        275                 280                 285             


Asn Pro Thr His Leu Ala Asp Phe Thr Gln Val Gln Thr Ile Gln Tyr 
    290                 295                 300                 


Ser Asn Ser Glu Asp Lys Asp Arg Lys Gly Met Leu Gln Leu Lys Ile 
305                 310                 315                 320 


Ala Gly Ala Pro Glu Pro Leu Thr Val Thr Ala Pro Ser Leu Thr Ile 
                325                 330                 335     


Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys Arg Leu Val Asn 
            340                 345                 350         


Gly Thr Ser Gln Ser Phe Ile Ile Arg Pro Gln Lys Glu Gly Glu Arg 
        355                 360                 365             


Ala Leu Pro Ser Ile Pro Lys Leu Ala Asn Ser Glu Lys Gln Gly Met 
    370                 375                 380                 


Arg Thr His Ala Val Ser Val Ser Glu Thr Asp Asp Tyr Ala Glu Ile 
385                 390                 395                 400 


Ile Asp Glu Glu Asp Thr Tyr Thr Met Pro Ser Thr Arg Asp Tyr Glu 
                405                 410                 415     


Ile Gln Arg Glu Arg Ile Glu Leu Gly Arg Cys Ile Gly Glu Gly Gln 
            420                 425                 430         


Phe Gly Asp Val His Gln Gly Ile Tyr Met Ser Pro Glu Asn Pro Ala 
        435                 440                 445             


Leu Ala Val Ala Ile Lys Thr Cys Lys Asn Cys Thr Ser Asp Ser Val 
    450                 455                 460                 


Arg Glu Lys Phe Leu Gln Glu Ala Leu Thr Met Arg Gln Phe Asp His 
465                 470                 475                 480 


Pro His Ile Val Lys Leu Ile Gly Val Ile Thr Glu Asn Pro Val Trp 
                485                 490                 495     


Ile Ile Met Glu Leu Cys Thr Leu Gly Glu Leu Arg Ser Phe Leu Gln 
            500                 505                 510         


Val Arg Lys Tyr Ser Leu Asp Leu Ala Ser Leu Ile Leu Tyr Ala Tyr 
        515                 520                 525             


Gln Leu Ser Thr Ala Leu Ala Tyr Leu Glu Ser Lys Arg Phe Val His 
    530                 535                 540                 


Arg Asp Ile Ala Ala Arg Asn Val Leu Val Ser Ser Asn Asp Cys Val 
545                 550                 555                 560 


Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Met Glu Asp Ser Thr Tyr 
                565                 570                 575     


Tyr Lys Ala Ser Lys Gly Lys Leu Pro Ile Lys Trp Met Ala Pro Glu 
            580                 585                 590         


Ser Ile Asn Phe Arg Arg Phe Thr Ser Ala Ser Asp Val Trp Met Phe 
        595                 600                 605             


Gly Val Cys Met Trp Glu Ile Leu Met His Gly Val Lys Pro Phe Gln 
    610                 615                 620                 


Gly Val Lys Asn Asn Asp Val Ile Gly Arg Ile Glu Asn Gly Glu Arg 
625                 630                 635                 640 


Leu Pro Met Pro Pro Asn Cys Pro Pro Thr Leu Tyr Ser Leu Met Thr 
                645                 650                 655     


Lys Cys Trp Ala Tyr Asp Pro Ser Arg Arg Pro Arg Phe Thr Glu Leu 
            660                 665                 670         


Lys Ala Gln Leu Ser Thr Ile Leu Glu Glu Glu Lys Ala Gln Gln Glu 
        675                 680                 685             


Glu Arg Met Arg Met Glu Ser Arg Arg Gln Ala Thr Val Ser Trp Asp 
    690                 695                 700                 


Ser Gly Gly Ser Asp Glu Ala Pro Pro Lys Pro Ser Arg Pro Gly Tyr 
705                 710                 715                 720 


Pro Ser Pro Arg Ser Ser Glu Gly Phe Tyr Pro Ser Pro Gln His Met 
                725                 730                 735     


Val Gln Thr Asn His Tyr Gln Val Ser Gly Tyr Pro Gly Ser His Gly 
            740                 745                 750         


Ile Thr Ala Met Ala Gly Ser Ile Tyr Pro Gly Gln Ala Ser Leu Leu 
        755                 760                 765             


Asp Gln Thr Asp Ser Trp Asn His Arg Pro Gln Glu Ile Ala Met Trp 
    770                 775                 780                 


Gln Pro Asn Val Glu Asp Ser Thr Val Leu Asp Leu Arg Gly Ile Gly 
785                 790                 795                 800 


Gln Val Leu Pro Thr His Leu Met Glu Glu Arg Leu Ile Arg Gln Gln 
                805                 810                 815     


Gln Glu Met Glu Glu Asp Gln Arg Trp Leu Glu Lys Glu Glu Arg Phe 
            820                 825                 830         


Leu Lys Pro Asp Val Arg Leu Ser Arg Gly Ser Ile Asp Arg Glu Asp 
        835                 840                 845             


Gly Ser Leu Gln Gly Pro Ile Gly Asn Gln His Ile Tyr Gln Pro Val 
    850                 855                 860                 


Gly Lys Pro Asp Pro Ala Ala Pro Pro Lys Lys Pro Pro Arg Pro Gly 
865                 870                 875                 880 


Ala Pro Gly His Leu Gly Ser Leu Ala Ser Leu Ser Ser Pro Ala Asp 
                885                 890                 895     


Ser Tyr Asn Glu Gly Val Lys Leu Gln Pro Gln Glu Ile Ser Pro Pro 
            900                 905                 910         


Pro Thr Ala Asn Leu Asp Arg Ser Asn Asp Lys Val Tyr Glu Asn Val 
        915                 920                 925             


Thr Gly Leu Val Lys Ala Val Ile Glu Met Ser Ser Lys Ile Gln Pro 
    930                 935                 940                 


Ala Pro Pro Glu Glu Tyr Val Pro Met Val Lys Glu Val Gly Leu Ala 
945                 950                 955                 960 


Leu Arg Thr Leu Leu Ala Thr Val Asp Glu Thr Ile Pro Leu Leu Pro 
                965                 970                 975     


Ala Ser Thr His Arg Glu Ile Glu Met Ala Gln Lys Leu Leu Asn Ser 
            980                 985                 990         


Asp Leu Gly Glu Leu Ile Asn Lys  Met Lys Leu Ala Gln  Gln Tyr Val 
        995                 1000                 1005             


Met Thr  Ser Leu Gln Gln Glu  Tyr Lys Lys Gln Met  Leu Thr Ala 
    1010                 1015                 1020             


Ala His  Ala Leu Ala Val Asp  Ala Lys Asn Leu Leu  Asp Val Ile 
    1025                 1030                 1035             


Asp Gln  Ala Arg Leu Lys Met  Leu Gly Gln Thr Arg  Pro His 
    1040                 1045                 1050         


