                         SEQUENCE LISTING

<110>  Inozyme Pharma, Inc.
       Huertas, Pedro
       Wenkert, Deborah
 
<120>  Treatment of ENPP1 Deficiency and ABCC6 Deficiency

<130>  4427-10902

<140>  Not Yet Assigned
<141>  2021-11-19

<150>  63/116,086
<151>  2020-11-19

<150>  63/116,106
<151>  2020-11-19

<150>  63/116,093
<151>  2020-11-19

<150>  63/219,229
<151>  2021-07-07

<150>  63/237,351
<151>  2021-08-26

<160>  115   

<170>  PatentIn version 3.5

<210>  1
<211>  925
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser Arg Gly Gly Glu Gly 
1               5                   10                  15      


Gly Arg Ala Pro Arg Glu Gly Pro Ala Gly Asn Gly Arg Asp Arg Gly 
            20                  25                  30          


Arg Ser His Ala Ala Glu Ala Pro Gly Asp Pro Gln Ala Ala Ala Ser 
        35                  40                  45              


Leu Leu Ala Pro Met Asp Val Gly Glu Glu Pro Leu Glu Lys Ala Ala 
    50                  55                  60                  


Arg Ala Arg Thr Ala Lys Asp Pro Asn Thr Tyr Lys Val Leu Ser Leu 
65                  70                  75                  80  


Val Leu Ser Val Cys Val Leu Thr Thr Ile Leu Gly Cys Ile Phe Gly 
                85                  90                  95      


Leu Lys Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys 
            100                 105                 110         


Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu 
        115                 120                 125             


Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu 
    130                 135                 140                 


His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr 
145                 150                 155                 160 


Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys 
                165                 170                 175     


Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu 
            180                 185                 190         


Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu 
        195                 200                 205             


Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr 
    210                 215                 220                 


Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys 
225                 230                 235                 240 


Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr 
                245                 250                 255     


Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His 
            260                 265                 270         


Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe 
        275                 280                 285             


Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu 
    290                 295                 300                 


Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe 
305                 310                 315                 320 


Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile 
                325                 330                 335     


Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala 
            340                 345                 350         


Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr 
        355                 360                 365             


Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro 
    370                 375                 380                 


Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val 
385                 390                 395                 400 


Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu 
                405                 410                 415     


Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys 
            420                 425                 430         


Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys 
        435                 440                 445             


Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp 
    450                 455                 460                 


Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys 
465                 470                 475                 480 


Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro 
                485                 490                 495     


Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe 
            500                 505                 510         


Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys 
        515                 520                 525             


Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met 
    530                 535                 540                 


Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu 
545                 550                 555                 560 


Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu 
                565                 570                 575     


Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn 
            580                 585                 590         


His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val 
        595                 600                 605             


His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu 
    610                 615                 620                 


Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr 
625                 630                 635                 640 


Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr 
                645                 650                 655     


Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys 
            660                 665                 670         


Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu 
        675                 680                 685             


Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser 
    690                 695                 700                 


Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu 
705                 710                 715                 720 


Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser 
                725                 730                 735     


Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile 
            740                 745                 750         


Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser 
        755                 760                 765             


Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr 
    770                 775                 780                 


Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp 
785                 790                 795                 800 


Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys 
                805                 810                 815     


Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe 
            820                 825                 830         


Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys 
        835                 840                 845             


Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn 
    850                 855                 860                 


Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu 
865                 870                 875                 880 


Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr 
                885                 890                 895     


Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu 
            900                 905                 910         


Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
        915                 920                 925 


<210>  2
<211>  827
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP1 Polypeptide

<400>  2

Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys Phe Glu 
1               5                   10                  15      


Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu Leu Gly 
            20                  25                  30          


Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu His Ile 
        35                  40                  45              


Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr Arg Ser 
    50                  55                  60                  


Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys Cys Ile 
65                  70                  75                  80  


Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu Glu Pro 
                85                  90                  95      


Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro 
            100                 105                 110         


Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His 
        115                 120                 125             


Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys Gly 
    130                 135                 140                 


Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro 
145                 150                 155                 160 


Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile 
                165                 170                 175     


Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe Ser Leu 
            180                 185                 190         


Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile 
        195                 200                 205             


Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp 
    210                 215                 220                 


Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile Tyr Lys 
225                 230                 235                 240 


Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val Leu 
                245                 250                 255     


Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr Thr Leu 
            260                 265                 270         


Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro Val Ser 
        275                 280                 285             


Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val Gly Met 
    290                 295                 300                 


Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu Asn Leu 
305                 310                 315                 320 


Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr 
                325                 330                 335     


Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys Val Ile 
            340                 345                 350         


Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr 
        355                 360                 365             


Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu 
    370                 375                 380                 


Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro Lys Arg 
385                 390                 395                 400 


Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu 
                405                 410                 415     


Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys 
            420                 425                 430         


Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met Gln Ala 
        435                 440                 445             


Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu Ala Asp 
    450                 455                 460                 


Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Asn 
465                 470                 475                 480 


Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu 
                485                 490                 495     


Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val His Pro 
            500                 505                 510         


Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys 
        515                 520                 525             


Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe 
    530                 535                 540                 


Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr Leu Pro 
545                 550                 555                 560 


Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys Leu Leu 
                565                 570                 575     


Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro 
            580                 585                 590         


Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser Thr Glu 
        595                 600                 605             


Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro 
    610                 615                 620                 


Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly 
625                 630                 635                 640 


Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser 
                645                 650                 655     


Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser Phe Gln 
            660                 665                 670         


Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr Ala Glu 
        675                 680                 685             


Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp Phe Asp 
    690                 695                 700                 


Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys Arg Arg 
705                 710                 715                 720 


Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe Ile Val 
                725                 730                 735     


Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys Glu Asn 
            740                 745                 750         


Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn Ser Glu 
        755                 760                 765             


Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu Leu Leu 
    770                 775                 780                 


Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr Gly Leu 
785                 790                 795                 800 


Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu Lys Leu 
                805                 810                 815     


Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
            820                 825         


<210>  3
<211>  1063
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP1 Polypeptide

<400>  3

Phe Thr Ala Gly Leu Lys Pro Ser Cys Ala Lys Glu Val Lys Ser Cys 
1               5                   10                  15      


Lys Gly Arg Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala 
            20                  25                  30          


Ala Cys Val Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys 
        35                  40                  45              


Ile Glu Pro Glu His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu 
    50                  55                  60                  


Lys Arg Leu Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp 
65                  70                  75                  80  


Lys Gly Asp Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys 
                85                  90                  95      


Ser Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro 
            100                 105                 110         


Ala Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe 
        115                 120                 125             


Arg Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser 
    130                 135                 140                 


Lys Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr 
145                 150                 155                 160 


Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr 
                165                 170                 175     


Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met 
            180                 185                 190         


Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp 
        195                 200                 205             


Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys 
    210                 215                 220                 


Ser Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile 
225                 230                 235                 240 


Phe Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu 
                245                 250                 255     


Arg Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg 
            260                 265                 270         


Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His 
        275                 280                 285             


Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val 
    290                 295                 300                 


Asp Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu 
305                 310                 315                 320 


His Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln 
                325                 330                 335     


Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val 
            340                 345                 350         


Lys Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser 
        355                 360                 365             


Asp Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg 
    370                 375                 380                 


Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys 
385                 390                 395                 400 


His Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu 
                405                 410                 415     


Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro 
            420                 425                 430         


Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val 
        435                 440                 445             


Phe Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys 
    450                 455                 460                 


His Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu 
465                 470                 475                 480 


Met Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His 
                485                 490                 495     


Gly Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His 
            500                 505                 510         


Pro Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro 
        515                 520                 525             


Arg Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu 
    530                 535                 540                 


Asp Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile 
545                 550                 555                 560 


Lys His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu 
                565                 570                 575     


Asn Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser 
            580                 585                 590         


Gln Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn 
        595                 600                 605             


Asp Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe 
    610                 615                 620                 


Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn 
625                 630                 635                 640 


Thr Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn 
                645                 650                 655     


Ser Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro 
            660                 665                 670         


Met Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu 
        675                 680                 685             


Leu Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly 
    690                 695                 700                 


Pro Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn 
705                 710                 715                 720 


Leu Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro 
                725                 730                 735     


Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr 
            740                 745                 750         


Pro Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His 
        755                 760                 765             


Arg Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser 
    770                 775                 780                 


Trp Val Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val 
785                 790                 795                 800 


Glu His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val 
                805                 810                 815     


Ser Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu 
            820                 825                 830         


Asp Leu Ile Asn Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        835                 840                 845             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    850                 855                 860                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
865                 870                 875                 880 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                885                 890                 895     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            900                 905                 910         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        915                 920                 925             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    930                 935                 940                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
945                 950                 955                 960 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
                965                 970                 975     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            980                 985                 990         


Ile Ala Val Glu Trp Glu Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys 
        995                 1000                 1005             


Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr 
    1010                 1015                 1020             


Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val 
    1025                 1030                 1035             


Phe Ser  Cys Ser Val Met His  Glu Ala Leu His Asn  His Tyr Thr 
    1040                 1045                 1050             


Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 
    1055                 1060             


<210>  4
<211>  1060
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP1 Polypeptide

<400>  4

Gly Leu Lys Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg 
1               5                   10                  15      


Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val 
            20                  25                  30          


Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro 
        35                  40                  45              


Glu His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu 
    50                  55                  60                  


Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp 
65                  70                  75                  80  


Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val 
                85                  90                  95      


Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe 
            100                 105                 110         


Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu 
        115                 120                 125             


Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys 
    130                 135                 140                 


Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys 
145                 150                 155                 160 


Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser 
                165                 170                 175     


His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser 
            180                 185                 190         


Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly 
        195                 200                 205             


Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr 
    210                 215                 220                 


Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp 
225                 230                 235                 240 


Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu 
                245                 250                 255     


Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe 
            260                 265                 270         


Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly 
        275                 280                 285             


Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met 
    290                 295                 300                 


Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys 
305                 310                 315                 320 


Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys 
                325                 330                 335     


Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile 
            340                 345                 350         


Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro 
        355                 360                 365             


Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser 
    370                 375                 380                 


Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu 
385                 390                 395                 400 


Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr 
                405                 410                 415     


Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg 
            420                 425                 430         


Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn 
        435                 440                 445             


Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile 
    450                 455                 460                 


Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp 
465                 470                 475                 480 


Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu 
                485                 490                 495     


Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu 
            500                 505                 510         


Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn 
        515                 520                 525             


Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln 
    530                 535                 540                 


Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu 
545                 550                 555                 560 


Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile 
                565                 570                 575     


Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile 
            580                 585                 590         


Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe 
        595                 600                 605             


Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro 
    610                 615                 620                 


Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val 
625                 630                 635                 640 


Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly 
                645                 650                 655     


Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln 
            660                 665                 670         


Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys 
        675                 680                 685             


Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe 
    690                 695                 700                 


Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln 
705                 710                 715                 720 


Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe 
                725                 730                 735     


Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His 
            740                 745                 750         


Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp 
        755                 760                 765             


Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu 
    770                 775                 780                 


Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile 
785                 790                 795                 800 


Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile 
                805                 810                 815     


Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Leu Ile 
            820                 825                 830         


Asn Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        835                 840                 845             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    850                 855                 860                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
865                 870                 875                 880 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                885                 890                 895     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            900                 905                 910         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        915                 920                 925             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    930                 935                 940                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
945                 950                 955                 960 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                965                 970                 975     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            980                 985                 990         


Glu Trp Glu Ser Asn Gly Gln Pro  Glu Asn Asn Tyr Lys  Thr Thr Pro 
        995                 1000                 1005             


Pro Val  Leu Asp Ser Asp Gly  Ser Phe Phe Leu Tyr  Ser Lys Leu 
    1010                 1015                 1020             


Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly Asn Val  Phe Ser Cys 
    1025                 1030                 1035             


Ser Val  Met His Glu Ala Leu  His Asn His Tyr Thr  Gln Lys Ser 
    1040                 1045                 1050             


Leu Ser  Leu Ser Pro Gly Lys  
    1055                 1060 


<210>  5
<211>  1057
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP1 Polypeptide

<400>  5

Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys Phe Glu 
1               5                   10                  15      


Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu Leu Gly 
            20                  25                  30          


Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu His Ile 
        35                  40                  45              


Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr Arg Ser 
    50                  55                  60                  


Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys Cys Ile 
65                  70                  75                  80  


Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu Glu Pro 
                85                  90                  95      


Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro 
            100                 105                 110         


Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His 
        115                 120                 125             


Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys Gly 
    130                 135                 140                 


Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro 
145                 150                 155                 160 


Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile 
                165                 170                 175     


Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe Ser Leu 
            180                 185                 190         


Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile 
        195                 200                 205             


Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp 
    210                 215                 220                 


Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile Tyr Lys 
225                 230                 235                 240 


Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val Leu 
                245                 250                 255     


Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr Thr Leu 
            260                 265                 270         


Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro Val Ser 
        275                 280                 285             


Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val Gly Met 
    290                 295                 300                 


Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu Asn Leu 
305                 310                 315                 320 


Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr 
                325                 330                 335     


Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys Val Ile 
            340                 345                 350         


Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr 
        355                 360                 365             


Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu 
    370                 375                 380                 


Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro Lys Arg 
385                 390                 395                 400 


Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu 
                405                 410                 415     


Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys 
            420                 425                 430         


Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met Gln Ala 
        435                 440                 445             


Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu Ala Asp 
    450                 455                 460                 


Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Asn 
465                 470                 475                 480 


Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu 
                485                 490                 495     


Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val His Pro 
            500                 505                 510         


Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys 
        515                 520                 525             


Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe 
    530                 535                 540                 


Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr Leu Pro 
545                 550                 555                 560 


Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys Leu Leu 
                565                 570                 575     


Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro 
            580                 585                 590         


Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser Thr Glu 
        595                 600                 605             


Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro 
    610                 615                 620                 


Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly 
625                 630                 635                 640 


Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser 
                645                 650                 655     


Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser Phe Gln 
            660                 665                 670         


Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr Ala Glu 
        675                 680                 685             


Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp Phe Asp 
    690                 695                 700                 


Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys Arg Arg 
705                 710                 715                 720 


Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe Ile Val 
                725                 730                 735     


Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys Glu Asn 
            740                 745                 750         


Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn Ser Glu 
        755                 760                 765             


Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu Leu Leu 
    770                 775                 780                 


Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr Gly Leu 
785                 790                 795                 800 


Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu Lys Leu 
                805                 810                 815     


Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Leu Ile Asn Asp Lys 
            820                 825                 830         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        835                 840                 845             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    850                 855                 860                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
865                 870                 875                 880 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                885                 890                 895     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            900                 905                 910         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        915                 920                 925             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    930                 935                 940                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
945                 950                 955                 960 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                965                 970                 975     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            980                 985                 990         


Ser Asn Gly Gln Pro Glu Asn Asn  Tyr Lys Thr Thr Pro  Pro Val Leu 
        995                 1000                 1005             


Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser Lys Leu  Thr Val Asp 
    1010                 1015                 1020             


Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe Ser Cys  Ser Val Met 
    1025                 1030                 1035             


His Glu  Ala Leu His Asn His  Tyr Thr Gln Lys Ser  Leu Ser Leu 
    1040                 1045                 1050             


Ser Pro  Gly Lys 
    1055         


<210>  6
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG1 Fc

<400>  6

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  7
<211>  906
<212>  PRT
<213>  Mus musculus

<400>  7

Met Glu Arg Asp Gly Asp Gln Ala Gly His Gly Pro Arg His Gly Ser 
1               5                   10                  15      


Ala Gly Asn Gly Arg Glu Leu Glu Ser Pro Ala Ala Ala Ser Leu Leu 
            20                  25                  30          


Ala Pro Met Asp Leu Gly Glu Glu Pro Leu Glu Lys Ala Glu Arg Ala 
        35                  40                  45              


Arg Pro Ala Lys Asp Pro Asn Thr Tyr Lys Val Leu Ser Leu Val Leu 
    50                  55                  60                  


Ser Val Cys Val Leu Thr Thr Ile Leu Gly Cys Ile Phe Gly Leu Lys 
65                  70                  75                  80  


Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys Phe Glu 
                85                  90                  95      


Arg Thr Phe Ser Asn Cys Arg Cys Asp Ala Ala Cys Val Ser Leu Gly 
            100                 105                 110         


Asn Cys Cys Leu Asp Phe Gln Glu Thr Cys Val Glu Pro Thr His Ile 
        115                 120                 125             


Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Ser Arg Phe 
    130                 135                 140                 


Val Cys Ser Cys Ala Asp Asp Cys Lys Thr His Asn Asp Cys Cys Ile 
145                 150                 155                 160 


Asn Tyr Ser Ser Val Cys Gln Asp Lys Lys Ser Trp Val Glu Glu Thr 
                165                 170                 175     


Cys Glu Ser Ile Asp Thr Pro Glu Cys Pro Ala Glu Phe Glu Ser Pro 
            180                 185                 190         


Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His 
        195                 200                 205             


Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Asn Cys Gly 
    210                 215                 220                 


Thr Tyr Thr Lys Asn Met Arg Pro Met Tyr Pro Thr Lys Thr Phe Pro 
225                 230                 235                 240 


Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile 
                245                 250                 255     


Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe Ser Leu 
            260                 265                 270         


Lys Ser Lys Glu Lys Phe Asn Pro Leu Trp Tyr Lys Gly Gln Pro Ile 
        275                 280                 285             


Trp Val Thr Ala Asn His Gln Glu Val Lys Ser Gly Thr Tyr Phe Trp 
    290                 295                 300                 


Pro Gly Ser Asp Val Glu Ile Asp Gly Ile Leu Pro Asp Ile Tyr Lys 
305                 310                 315                 320 


Val Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val Leu 
                325                 330                 335     


Glu Trp Leu Gln Leu Pro Ser His Glu Arg Pro His Phe Tyr Thr Leu 
            340                 345                 350         


Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser His Gly Pro Val Ser 
        355                 360                 365             


Ser Glu Val Ile Lys Ala Leu Gln Lys Val Asp Arg Leu Val Gly Met 
    370                 375                 380                 


Leu Met Asp Gly Leu Lys Asp Leu Gly Leu Asp Lys Cys Leu Asn Leu 
385                 390                 395                 400 


Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr 
                405                 410                 415     


Val Tyr Leu Asn Lys Tyr Leu Gly Asp Val Asn Asn Val Lys Val Val 
            420                 425                 430         


Tyr Gly Pro Ala Ala Arg Leu Arg Pro Thr Asp Val Pro Glu Thr Tyr 
        435                 440                 445             


Tyr Ser Phe Asn Tyr Glu Ala Leu Ala Lys Asn Leu Ser Cys Arg Glu 
    450                 455                 460                 


Pro Asn Gln His Phe Arg Pro Tyr Leu Lys Pro Phe Leu Pro Lys Arg 
465                 470                 475                 480 


Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu 
                485                 490                 495     


Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys 
            500                 505                 510         


Gly Ser Gly Phe His Gly Ser Asp Asn Leu Phe Ser Asn Met Gln Ala 
        515                 520                 525             


Leu Phe Ile Gly Tyr Gly Pro Ala Phe Lys His Gly Ala Glu Val Asp 
    530                 535                 540                 


Ser Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Gly 
545                 550                 555                 560 


Leu Ile Pro Ala Pro Asn Asn Gly Ser His Gly Ser Leu Asn His Leu 
                565                 570                 575     


Leu Lys Lys Pro Ile Tyr Asn Pro Ser His Pro Lys Glu Glu Gly Phe 
            580                 585                 590         


Leu Ser Gln Cys Pro Ile Lys Ser Thr Ser Asn Asp Leu Gly Cys Thr 
        595                 600                 605             


Cys Asp Pro Trp Ile Val Pro Ile Lys Asp Phe Glu Lys Gln Leu Asn 
    610                 615                 620                 


Leu Thr Thr Glu Asp Val Asp Asp Ile Tyr His Met Thr Val Pro Tyr 
625                 630                 635                 640 


Gly Arg Pro Arg Ile Leu Leu Lys Gln His Arg Val Cys Leu Leu Gln 
                645                 650                 655     


Gln Gln Gln Phe Leu Thr Gly Tyr Ser Leu Asp Leu Leu Met Pro Leu 
            660                 665                 670         


Trp Ala Ser Tyr Thr Phe Leu Ser Asn Asp Gln Phe Ser Arg Asp Asp 
        675                 680                 685             


Phe Ser Asn Cys Leu Tyr Gln Asp Leu Arg Ile Pro Leu Ser Pro Val 
    690                 695                 700                 


His Lys Cys Ser Tyr Tyr Lys Ser Asn Ser Lys Leu Ser Tyr Gly Phe 
705                 710                 715                 720 


Leu Thr Pro Pro Arg Leu Asn Arg Val Ser Asn His Ile Tyr Ser Glu 
                725                 730                 735     


Ala Leu Leu Thr Ser Asn Ile Val Pro Met Tyr Gln Ser Phe Gln Val 
            740                 745                 750         


Ile Trp His Tyr Leu His Asp Thr Leu Leu Gln Arg Tyr Ala His Glu 
        755                 760                 765             


Arg Asn Gly Ile Asn Val Val Ser Gly Pro Val Phe Asp Phe Asp Tyr 
    770                 775                 780                 


Asp Gly Arg Tyr Asp Ser Leu Glu Ile Leu Lys Gln Asn Ser Arg Val 
785                 790                 795                 800 


Ile Arg Ser Gln Glu Ile Leu Ile Pro Thr His Phe Phe Ile Val Leu 
                805                 810                 815     


Thr Ser Cys Lys Gln Leu Ser Glu Thr Pro Leu Glu Cys Ser Ala Leu 
            820                 825                 830         


Glu Ser Ser Ala Tyr Ile Leu Pro His Arg Pro Asp Asn Ile Glu Ser 
        835                 840                 845             


Cys Thr His Gly Lys Arg Glu Ser Ser Trp Val Glu Glu Leu Leu Thr 
    850                 855                 860                 


Leu His Arg Ala Arg Val Thr Asp Val Glu Leu Ile Thr Gly Leu Ser 
865                 870                 875                 880 


Phe Tyr Gln Asp Arg Gln Glu Ser Val Ser Glu Leu Leu Arg Leu Lys 
                885                 890                 895     


Thr His Leu Pro Ile Phe Ser Gln Glu Asp 
            900                 905     


<210>  8
<211>  924
<212>  PRT
<213>  Bos taurus

<400>  8

Met Glu Arg Asp Ser Cys Ala Gly Gly Gly Ser Arg Gly Gly Glu Gly 
1               5                   10                  15      


Gly Arg Gly Pro Arg Glu Gly Leu Ala Gly Asn Gly Arg Asp Pro Gly 
            20                  25                  30          


Pro Gly Arg Ala Ala Glu Ala Ser Gly Glu Pro Gln Ala Ala Ala Ser 
        35                  40                  45              


Leu Leu Ala Pro Met Asp Leu Gly Glu Glu Pro Leu Glu Arg Ala Ala 
    50                  55                  60                  


Arg Ala Arg Pro Ala Lys Asp Pro Asn Thr Tyr Lys Val Leu Ser Leu 
65                  70                  75                  80  


Val Leu Ser Val Cys Val Leu Thr Thr Ile Leu Gly Cys Ile Phe Gly 
                85                  90                  95      


Leu Lys Pro Ser Cys Ala Lys Glu Ile Lys Ser Cys Lys Gly Arg Cys 
            100                 105                 110         


Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Asp 
        115                 120                 125             


Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu 
    130                 135                 140                 


Arg Ile Trp Thr Cys Thr Lys Phe Arg Cys Gly Glu Lys Arg Leu Ser 
145                 150                 155                 160 


Arg Ser Leu Cys Ser Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys 
                165                 170                 175     


Cys Ile Asn His Gly Ser Val Cys Arg Gly Glu Lys Ser Trp Ala Glu 
            180                 185                 190         


Glu Glu Cys Asp Ser Ile Asp Glu Pro Gln Cys Pro Ala Gly Phe Glu 
        195                 200                 205             


Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr 
    210                 215                 220                 


Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Thr 
225                 230                 235                 240 


Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr 
                245                 250                 255     


Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His 
            260                 265                 270         


Gly Ile Ile Asp Asn Asn Ile Tyr Asp Pro Gln Met Asn Ala Asn Phe 
        275                 280                 285             


Ala Leu Lys Asn Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu 
    290                 295                 300                 


Pro Ile Trp Leu Thr Ala Lys Tyr Gln Gly Leu Lys Thr Gly Thr Phe 
305                 310                 315                 320 


Phe Trp Pro Gly Ser Asp Val Lys Ile Asn Gly Ile Phe Pro Asp Ile 
                325                 330                 335     


Tyr Lys Ile Tyr Asn Val Ser Val Pro Phe Glu Glu Arg Ile Leu Ala 
            340                 345                 350         


Ile Leu Lys Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr 
        355                 360                 365             


Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro 
    370                 375                 380                 


Val Ser Ser Glu Val Ile Arg Ala Leu Gln Arg Val Asp Asn Met Val 
385                 390                 395                 400 


Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu 
                405                 410                 415     


Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys 
            420                 425                 430         


Lys Tyr Val Tyr Leu Asn Lys Tyr Leu Gly Asp Thr Lys Asp Tyr Lys 
        435                 440                 445             


Val Val Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp 
    450                 455                 460                 


Lys Tyr Tyr Ser Phe Asp Tyr Glu Gly Ile Ala Lys Asn Leu Ser Cys 
465                 470                 475                 480 


Gln Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro 
                485                 490                 495     


Lys Arg Leu His Phe Ala Lys Asn Asp Arg Ile Glu Arg Leu Thr Phe 
            500                 505                 510         


Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys 
        515                 520                 525             


Tyr Cys Gly Gly Gly Phe His Gly Ser Asp Asn Thr Phe Leu Asn Met 
    530                 535                 540                 


Gln Ala Leu Phe Ile Gly Tyr Gly Pro Gly Phe Lys His Ser Thr Glu 
545                 550                 555                 560 


Val Asp Ser Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu 
                565                 570                 575     


Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn 
            580                 585                 590         


His Leu Leu Ser Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val 
        595                 600                 605             


Arg Pro Leu Val Gln Cys Pro Phe Thr Arg Ala Pro Arg Glu Ser Leu 
    610                 615                 620                 


Asp Cys Ser Cys Asp Pro Ser Ile Leu Pro Ile Val Asp Phe Gln Thr 
625                 630                 635                 640 


Gln Leu Asn Leu Thr Met Ala Glu Glu Lys Thr Ile Lys Arg Gly Ala 
                645                 650                 655     


Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Asn Ser Thr Val Cys Leu 
            660                 665                 670         


Leu Tyr Gln His Gln Phe Val Ser Gly Tyr Ser Arg Asp Ile Leu Met 
        675                 680                 685             


Pro Leu Trp Thr Ser Tyr Thr Ile Gly Arg Asn Asp Ser Phe Ser Thr 
    690                 695                 700                 


Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Leu Arg Ile Pro Leu Ser 
705                 710                 715                 720 


Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Ala Lys Leu Ser Tyr 
                725                 730                 735     


Gly Leu Leu Ser Pro Pro Gln Leu His Lys Gly Ser Ser Gln Val Tyr 
            740                 745                 750         


Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser Phe 
        755                 760                 765             


Gln Val Ile Trp His Tyr Leu His Gly Thr Leu Leu Gln Arg Tyr Ala 
    770                 775                 780                 


Glu Glu Arg Asn Gly Leu Asn Val Val Ser Gly Pro Val Phe Asp Ser 
785                 790                 795                 800 


Asp Tyr Asp Gly Arg Tyr Asp Ser Leu Glu Thr Leu Lys Gln Asn Ser 
                805                 810                 815     


Lys Ile Ile Arg Asn Leu Glu Val Leu Ile Pro Thr His Phe Phe Leu 
            820                 825                 830         


Val Leu Thr Ser Cys Lys Asn Thr Ser Gln Thr Pro Leu Gln Cys Glu 
        835                 840                 845             


Asn Leu Asp Ala Met Ala Phe Ile Leu Pro His Lys Thr Asp Asn Ser 
    850                 855                 860                 


Glu Ser Cys Ala His Gly Lys His Glu Ser Leu Trp Val Glu Glu Leu 
865                 870                 875                 880 


Leu Lys Leu His Thr Ala Arg Ile Thr Asp Val Glu His Ile Thr Gly 
                885                 890                 895     


Leu Ser Phe Tyr Gln Glu Arg Lys Glu Pro Ile Ser Asp Ile Leu Lys 
            900                 905                 910         


Leu Lys Thr His Leu Pro Thr Phe Asn Gln Glu Asp 
        915                 920                 


<210>  9
<211>  925
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  9

Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser Arg Gly Gly Glu Gly 
1               5                   10                  15      


Gly Arg Ala Pro Arg Glu Gly Pro Ala Gly Asn Ser Arg Asp Pro Gly 
            20                  25                  30          


Arg Ser His Ala Ala Glu Ala Pro Gly Asn Pro Gln Ala Ala Ala Ser 
        35                  40                  45              


Leu Leu Ala Pro Met Asp Val Gly Glu Glu Pro Leu Glu Lys Ala Ala 
    50                  55                  60                  


Arg Ala Arg Thr Ala Lys Asp Pro Asn Thr Tyr Lys Val Leu Ser Leu 
65                  70                  75                  80  


Val Leu Ser Val Cys Val Leu Thr Thr Ile Leu Gly Cys Ile Phe Gly 
                85                  90                  95      


Leu Lys Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys 
            100                 105                 110         


Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu 
        115                 120                 125             


Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu 
    130                 135                 140                 


His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr 
145                 150                 155                 160 


Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Gln Gly Asp Cys 
                165                 170                 175     


Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu 
            180                 185                 190         


Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu 
        195                 200                 205             


Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr 
    210                 215                 220                 


Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys 
225                 230                 235                 240 


Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr 
                245                 250                 255     


Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His 
            260                 265                 270         


Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe 
        275                 280                 285             


Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu 
    290                 295                 300                 


Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe 
305                 310                 315                 320 


Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile 
                325                 330                 335     


Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala 
            340                 345                 350         


Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr 
        355                 360                 365             


Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro 
    370                 375                 380                 


Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Asn Met Val 
385                 390                 395                 400 


Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu 
                405                 410                 415     


Asn Leu Ile Leu Val Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys 
            420                 425                 430         


Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys 
        435                 440                 445             


Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp 
    450                 455                 460                 


Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys 
465                 470                 475                 480 


Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro 
                485                 490                 495     


Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe 
            500                 505                 510         


Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys 
        515                 520                 525             


Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Ile Phe Ser Asn Met 
    530                 535                 540                 


Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu 
545                 550                 555                 560 


Val Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu 
                565                 570                 575     


Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn 
            580                 585                 590         


His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val 
        595                 600                 605             


His Pro Leu Ile Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu 
    610                 615                 620                 


Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr 
625                 630                 635                 640 


Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Asn Ile Lys His Glu Thr 
                645                 650                 655     


Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Lys Asn Thr Ile Cys 
            660                 665                 670         


Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu 
        675                 680                 685             


Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser 
    690                 695                 700                 


Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Ser Leu 
705                 710                 715                 720 


Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser 
                725                 730                 735     


Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Arg Gly Ile 
            740                 745                 750         


Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser 
        755                 760                 765             


Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr 
    770                 775                 780                 


Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp 
785                 790                 795                 800 


Phe Asp Tyr Asp Gly Arg Tyr Asp Ser Leu Glu Ile Leu Arg Gln Lys 
                805                 810                 815     


Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe 
            820                 825                 830         


Ile Val Leu Thr Ser Cys Lys Asp Ala Ser Gln Thr Pro Leu His Cys 
        835                 840                 845             


Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn 
    850                 855                 860                 


Ser Glu Ser Cys Leu His Gly Lys His Glu Ser Ser Trp Val Glu Glu 
865                 870                 875                 880 


Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr 
                885                 890                 895     


Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu 
            900                 905                 910         


Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
        915                 920                 925 


<210>  10
<211>  925
<212>  PRT
<213>  Papio hamadryas

<400>  10

Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser Gln Gly Gly Gly Lys 
1               5                   10                  15      


Gly Gly Arg Gly Pro Arg Glu Gly Leu Ala Gly Asn Gly Arg Asp Pro 
            20                  25                  30          


Ser His Gly Gln Ala Ser Glu Ala Pro Gly Asp Pro Gln Ala Ala Ala 
        35                  40                  45              


Ser Leu Leu Ala Pro Met Asp Leu Gly Glu Glu Pro Leu Glu Lys Ala 
    50                  55                  60                  


Ala Gly Ala Arg Pro Ala Lys Asp Pro Asn Thr Tyr Lys Val Leu Ser 
65                  70                  75                  80  


Leu Val Leu Ser Val Cys Val Leu Thr Thr Ile Leu Gly Cys Ile Phe 
                85                  90                  95      


Gly Leu Lys Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg 
            100                 105                 110         


Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Val Ala Cys Val 
        115                 120                 125             


Asp Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro 
    130                 135                 140                 


Glu Arg Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu 
145                 150                 155                 160 


Ser Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Glu Arg Gly Asp 
                165                 170                 175     


Cys Cys Ile Asn Tyr Ser Ala Val Cys Gln Gly Glu Lys Ser Trp Val 
            180                 185                 190         


Glu Glu Thr Cys Glu Asn Ile Asn Glu Pro Gln Cys Pro Glu Gly Phe 
        195                 200                 205             


Glu Met Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu 
    210                 215                 220                 


Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys 
225                 230                 235                 240 


Lys Cys Gly Thr Tyr Ala Lys Asn Met Arg Pro Val Tyr Pro Thr Lys 
                245                 250                 255     


Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser 
            260                 265                 270         


His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser 
        275                 280                 285             


Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly 
    290                 295                 300                 


Glu Pro Ile Trp Leu Thr Ala Lys Tyr Gln Gly Leu Arg Ser Gly Thr 
305                 310                 315                 320 


Phe Phe Trp Pro Gly Ser Asp Val Lys Ile Asn Gly Ile Phe Pro Asp 
                325                 330                 335     


Ile Tyr Lys Ile Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu 
            340                 345                 350         


Ala Ile Leu Lys Trp Leu Arg Leu Pro Lys Asp Glu Arg Pro His Phe 
        355                 360                 365             


Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly 
    370                 375                 380                 


Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Asn Met 
385                 390                 395                 400 


Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Gln Cys 
                405                 410                 415     


Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys 
            420                 425                 430         


Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Thr Lys Asn Ile 
        435                 440                 445             


Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro 
    450                 455                 460                 


Glu Lys Tyr Tyr Ser Phe Asn Tyr Glu Asn Ile Ala Arg Asn Leu Ser 
465                 470                 475                 480 


Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu 
                485                 490                 495     


Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr 
            500                 505                 510         


Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Ser Pro Ser Glu Arg 
        515                 520                 525             


Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn 
    530                 535                 540                 


Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Gln His Gly Ile 
545                 550                 555                 560 


Glu Val Asp Ser Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp 
                565                 570                 575     


Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu 
            580                 585                 590         


Asn His Leu Leu Lys Asn Pro Ile Tyr Thr Pro Lys His Pro Lys Glu 
        595                 600                 605             


Val Gln Pro Ser Val Gln Cys Pro Leu Ala Gly Ser Pro Arg Asp Ser 
    610                 615                 620                 


Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Val Asp Phe Gln 
625                 630                 635                 640 


Thr Gln Phe Asn Leu Thr Thr Ala Glu Glu Lys Asn Ile Asn Arg Ala 
                645                 650                 655     


Ser Leu Pro Tyr Gly Arg Pro Arg Leu Leu Gln Lys Lys Ser Ser Val 
            660                 665                 670         


Cys Leu Leu Tyr Gln His Gln Phe Val Ser Gly Tyr Ser His Asp Val 
        675                 680                 685             


Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asn Arg Asn Asp Ser Phe 
    690                 695                 700                 


Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Leu Arg Ile Ser 
705                 710                 715                 720 


Phe Ser Pro Ile His Asn Cys Ser Phe Tyr Lys Asn Asn Ala Lys Leu 
                725                 730                 735     


Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Ser Lys Asp Ser Ser Gln 
            740                 745                 750         


Ile Tyr Ser Glu Ala Leu Leu Thr Ser Asn Ile Val Pro Met Tyr Gln 
        755                 760                 765             


Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Gln Arg 
    770                 775                 780                 


Tyr Ala Glu Glu Arg Asn Ser Ile Asn Val Val Ser Gly Pro Val Phe 
785                 790                 795                 800 


Asp Ser Asp Tyr Asp Gly Arg Tyr Asp Ser Ser Glu Ala Leu Lys Arg 
                805                 810                 815     


Asn Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe 
            820                 825                 830         


Phe Ile Val Ile Thr Ser Cys Lys Asn Thr Ser Gln Thr Pro Leu Gln 
        835                 840                 845             


Cys Asp Asn Leu Asp Pro Leu Ala Phe Ile Leu Pro His Arg Ser Asp 
    850                 855                 860                 


Asn Ser Glu Ser Cys Val His Glu Lys Arg Glu Ser Ser Trp Ile Glu 
865                 870                 875                 880 


Glu Leu Leu Met Met His Arg Ala Arg Ile Met Asp Val Glu His Ile 
                885                 890                 895     


Thr Gly Leu Ser Phe Tyr Gln Glu Arg Lys Glu Pro Val Ser Asp Ile 
            900                 905                 910         


Leu Lys Leu Lys Thr His Leu Pro Thr Val Ser Gln Glu 
        915                 920                 925 


<210>  11

<400>  11
000

<210>  12

<400>  12
000

<210>  13

<400>  13
000

<210>  14

<400>  14
000

<210>  15

<400>  15
000

<210>  16

<400>  16
000

<210>  17

<400>  17
000

<210>  18

<400>  18
000

<210>  19

<400>  19
000

<210>  20

<400>  20
000

<210>  21

<400>  21
000

<210>  22

<400>  22
000

<210>  23

<400>  23
000

<210>  24

<400>  24
000

<210>  25

<400>  25
000

<210>  26

<400>  26
000

<210>  27
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  27

Gly Gly Gly Ala 
1               


<210>  28
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  28

Gly Gly Gly Ser 
1               


<210>  29
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  29

Gly Gly Gly Gly 
1               


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  30

Gly Gly Gly Gly Ala 
1               5   


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  31

Gly Gly Gly Gly Ser 
1               5   


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  32

Gly Gly Gly Gly Gly 
1               5   


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  33

Gly Gly Ala Gly 
1               


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  34

Gly Gly Ser Gly 
1               


<210>  35
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  35

Ala Gly Gly Gly 
1               


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  36

Ser Gly Gly Gly Gly 
1               5   


<210>  37
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  37

Ser Gly Gly Gly 
1               


<210>  38
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  38

Gly Ala Gly Ala 
1               


<210>  39
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  39

Gly Ser Gly Ser 
1               


<210>  40
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  40

Gly Ala Gly Ala Gly Ala 
1               5       


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  41

Gly Ser Gly Ser Gly Ser 
1               5       


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  42

Gly Ala Gly Ala Gly Ala Gly Ala 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  43

Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  44

Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
1               5                   10  


<210>  45
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  45

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210>  46
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  46

Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
1               5                   10          


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  47

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10          


<210>  48
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  48

Gly Gly Ala Gly Gly Ala 
1               5       


<210>  49
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  49

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  50

Gly Gly Ala Gly Gly Ala Gly Gly Ala 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  51

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  52

Gly Gly Ala Gly Gly Ala Gly Gly Ala Gly Gly Ala 
1               5                   10          


<210>  53
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  53

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10          


<210>  54
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  54

Gly Gly Ala Gly 
1               


<210>  55
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  55

Gly Gly Ser Gly 
1               


<210>  56
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  56

Gly Gly Ala Gly 
1               


<210>  57
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  57

Gly Gly Ser Gly 
1               


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  58

Gly Gly Ala Gly Gly Gly Ala Gly 
1               5               


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  59

Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210>  60
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  60

Gly Gly Ala Gly Gly Gly Ala Gly Gly Gly Ala Gly 
1               5                   10          


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  61

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10          


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  62

Gly Gly Gly Gly Ala 
1               5   


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  63

Gly Gly Gly Gly Ser 
1               5   


<210>  64
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  64

Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala 
1               5                   10                  15  


<210>  65
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  65

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  66

Gly Gly Gly Ala Gly 
1               5   


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  67

Gly Gly Gly Ala Gly Gly 
1               5       


<210>  68
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  68

Gly Gly Gly Ala Gly Gly Gly 
1               5           


<210>  69

<400>  69
000

<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  70

Thr Gly Gly Gly Gly 
1               5   


<210>  71
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  71

Ala Ala Ala Leu 
1               


<210>  72
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  72

Ala Ala Ala Lys 
1               


<210>  73
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  73

Ala Ala Ala Arg 
1               


<210>  74
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  74

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  75
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  75

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  76
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  76

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  77
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  77

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  78

Gly Glu Asn Leu Tyr Phe Gln Ser Gly Gly 
1               5                   10  


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  79

Ser Ala Cys Tyr Cys Glu Leu Ser 
1               5               


<210>  80
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  80

Arg Ser Ile Ala Thr 
1               5   


<210>  81
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  81

Arg Pro Ala Cys Lys Ile Pro Asn Asp Leu Lys Gln Lys Val Met Asn 
1               5                   10                  15      


His 
    


<210>  82
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  82

Gly Gly Ser Ala Gly Gly Ser Gly Ser Gly Ser Ser Gly Gly Ser Ser 
1               5                   10                  15      


Gly Ala Ser Gly Thr Gly Thr Ala Gly Gly Thr Gly Ser Gly Ser Gly 
            20                  25                  30          


Thr Gly Ser Gly 
        35      


<210>  83
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  83

Ala Ala Ala Asn Ser Ser Ile Asp Leu Ile Ser Val Pro Val Asp Ser 
1               5                   10                  15      


Arg 
    


<210>  84
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  84

Gly Gly Ser Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly 
1               5                   10                  15      


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser 
        35      


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  85

Glu Ala Ala Ala Lys 
1               5   


<210>  86
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  86

Pro Ala Pro Ala Pro 
1               5   


<210>  87

<400>  87
000

<210>  88

<400>  88
000

<210>  89

<400>  89
000

<210>  90

<400>  90
000

<210>  91
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  MISC_FEATURE
<223>  Features section of the listing that any one or all of amino 
       acids 1-15 can either be present or absent

<400>  91

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15  


<210>  92
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  92

Asp Ser Ser Ser Glu Glu Lys Phe Leu Arg Arg Ile Gly Arg Phe Gly 
1               5                   10                  15      


<210>  93
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  93

Glu Glu Glu Glu Glu Glu Glu Pro Arg Gly Asp Thr 
1               5                   10          


<210>  94
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  94

Ala Pro Trp His Leu Ser Ser Gln Tyr Ser Arg Thr 
1               5                   10          


<210>  95
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  95

Ser Thr Leu Pro Ile Pro His Glu Phe Ser Arg Glu 
1               5                   10          


<210>  96
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  96

Val Thr Lys His Leu Asn Gln Ile Ser Gln Ser Tyr 
1               5                   10          


<210>  97
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  MISC_FEATURE
<223>  Features section of the listing that any one or all of amino 
       acids 2-15 can either be present or absent

<400>  97

Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
1               5                   10                  15  


<210>  98
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  98

Arg Ser Gly Ser Gly Gly Ser 
1               5           


<210>  99
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  MISC_FEATURE
<223>  Features section of the listing that any one or all of amino 
       acids 2-15 can either be present or absent

<400>  99

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
1               5                   10                  15  


<210>  100
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  100

Leu Val Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10                  15      


<210>  101
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  101

Val Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10                  15  


<210>  102
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  102

Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10                  


<210>  103
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  103

Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10              


<210>  104
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  104

Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10          


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  105

Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10      


<210>  106
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  106

Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10  


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  107

Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  108

Gly Leu Gly Leu Gly Leu Arg Lys 
1               5               


<210>  109
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  109

Leu Gly Leu Gly Leu Arg Lys 
1               5           


<210>  110
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  110

Gly Leu Gly Leu Arg Lys 
1               5       


<210>  111
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  111

Leu Gly Leu Arg Lys 
1               5   


<210>  112
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  112

Gly Leu Arg Lys 
1               


<210>  113

<400>  113
000

<210>  114

<400>  114
000

<210>  115
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  MISC_FEATURE
<223>  Features section of the listing that any one or all of amino 
       acids 2-15 can either be present or absent

<400>  115

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15  


