                         SEQUENCE LISTING

<110>  Seattle Children's Hospital D/B/A Seattle Children's 
       Research Institute
       Battell Memorial Institute
 
<120>  IMMUNOMODULATORY CLINICAL BIOMARKER PROFILES AND USES THEREOF

<130>  S281-0022PCT/SCRI.349WO

<150>  63/116,750
<151>  2020-11-20

<150>  63/166,952
<151>  2021-03-26

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward PCR primer for actin

<400>  1
gagaaaatct ggcaccacac c                                                 21


<210>  2
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse PCR primer for actin

<400>  2
ggatagcaca gcctggatag caa                                               23


<210>  3
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward PCR primer for IL-18R1

<400>  3
gtggaagatc gcagtaatat agttccgg                                          28


<210>  4
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse PCR primer for IL-18R1

<400>  4
cattcagcaa agcagagcag ttga                                              24


<210>  5
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward PCR primer for IL-18RAP

<400>  5
gattctgtag attctcccag cg                                                22


<210>  6
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse PCR primer for IL-18RAP

<400>  6
cctgagtatc cccttcattt ctgg                                              24


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward PCR primer for CD161

<400>  7
aaatgcagtg tggacattca a                                                 21


<210>  8
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse PCR primer for CD161

<400>  8
ctcggagttg ctgccaata                                                    19


<210>  9
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      


Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Ala Glu Asp Asp Glu Asn 
            20                  25                  30          


Leu Glu Ser Asp Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile 
        35                  40                  45              


Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro 
    50                  55                  60                  


Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg 
65                  70                  75                  80  


Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met 
                85                  90                  95      


Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys 
            100                 105                 110         


Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile 
        115                 120                 125             


Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
    130                 135                 140                 


His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe 
145                 150                 155                 160 


Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys 
                165                 170                 175     


Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu 
            180                 185                 190         


Asp 
    


<210>  10
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  10

Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 
            20                  25                  30          


Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 
        35                  40                  45              


Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 
65                  70                  75                  80  


Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 
                85                  90                  95      


Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 
            100                 105                 110         


Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 
        115                 120                 125             


Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 
    130                 135                 140                 


Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp 
145                 150                 155         


<210>  11
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 
1               5                   10                  15      


Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 
            20                  25                  30          


Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 
        35                  40                  45              


Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 
    50                  55                  60                  


Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Asn Gly 
65                  70                  75                  80  


Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn Phe Ser 
                85                  90                  95      


Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu Pro Gly 
            100                 105                 110         


Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr Gly Thr 
        115                 120                 125             


Gln Leu Cys Lys Ala Leu Val Leu Glu Gln Leu Thr Pro Ala Leu His 
    130                 135                 140                 


Ser Thr Asn Phe Ser Cys Val Leu Val Asp Pro Glu Gln Val Val Gln 
145                 150                 155                 160 


Arg His Val Val Leu Ala Gln Leu Trp Ala Gly Leu Arg Ala Thr Leu 
                165                 170                 175     


Pro Pro Thr Gln Glu Ala Leu Pro Ser Ser His Ser Ser Pro Gln Gln 
            180                 185                 190         


Gln Gly 
        


<210>  12
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  12

Thr Pro Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser 
1               5                   10                  15      


Thr Lys Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys 
            20                  25                  30          


Gln Cys Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu 
        35                  40                  45              


Asn Gly Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn 
    50                  55                  60                  


Phe Ser Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu 
65                  70                  75                  80  


Pro Gly Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr 
                85                  90                  95      


Gly Thr Gln Leu Cys Lys Ala Leu Val Leu Glu Gln Leu Thr Pro Ala 
            100                 105                 110         


Leu His Ser Thr Asn Phe Ser Cys Val Leu Val Asp Pro Glu Gln Val 
        115                 120                 125             


Val Gln Arg His Val Val Leu Ala Gln Leu Trp Ala Gly Leu Arg Ala 
    130                 135                 140                 


Thr Leu Pro Pro Thr Gln Glu Ala Leu Pro Ser Ser His Ser Ser Pro 
145                 150                 155                 160 


Gln Gln Gln Gly 
                


<210>  13
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Asn Cys Arg Glu Leu Pro Leu Thr Leu Trp Val Leu Ile Ser Val 
1               5                   10                  15      


Ser Thr Ala Glu Ser Cys Thr Ser Arg Pro His Ile Thr Val Val Glu 
            20                  25                  30          


Gly Glu Pro Phe Tyr Leu Lys His Cys Ser Cys Ser Leu Ala His Glu 
        35                  40                  45              


Ile Glu Thr Thr Thr Lys Ser Trp Tyr Lys Ser Ser Gly Ser Gln Glu 
    50                  55                  60                  


His Val Glu Leu Asn Pro Arg Ser Ser Ser Arg Ile Ala Leu His Asp 
65                  70                  75                  80  


Cys Val Leu Glu Phe Trp Pro Val Glu Leu Asn Asp Thr Gly Ser Tyr 
                85                  90                  95      


Phe Phe Gln Met Lys Asn Tyr Thr Gln Lys Trp Lys Leu Asn Val Ile 
            100                 105                 110         


Arg Arg Asn Lys His Ser Cys Phe Thr Glu Arg Gln Val Thr Ser Lys 
        115                 120                 125             


Ile Val Glu Val Lys Lys Phe Phe Gln Ile Thr Cys Glu Asn Ser Tyr 
    130                 135                 140                 


Tyr Gln Thr Leu Val Asn Ser Thr Ser Leu Tyr Lys Asn Cys Lys Lys 
145                 150                 155                 160 


Leu Leu Leu Glu Asn Asn Lys Asn Pro Thr Ile Lys Lys Asn Ala Glu 
                165                 170                 175     


Phe Glu Asp Gln Gly Tyr Tyr Ser Cys Val His Phe Leu His His Asn 
            180                 185                 190         


Gly Lys Leu Phe Asn Ile Thr Lys Thr Phe Asn Ile Thr Ile Val Glu 
        195                 200                 205             


Asp Arg Ser Asn Ile Val Pro Val Leu Leu Gly Pro Lys Leu Asn His 
    210                 215                 220                 


Val Ala Val Glu Leu Gly Lys Asn Val Arg Leu Asn Cys Ser Ala Leu 
225                 230                 235                 240 


Leu Asn Glu Glu Asp Val Ile Tyr Trp Met Phe Gly Glu Glu Asn Gly 
                245                 250                 255     


Ser Asp Pro Asn Ile His Glu Glu Lys Glu Met Arg Ile Met Thr Pro 
            260                 265                 270         


Glu Gly Lys Trp His Ala Ser Lys Val Leu Arg Ile Glu Asn Ile Gly 
        275                 280                 285             


Glu Ser Asn Leu Asn Val Leu Tyr Asn Cys Thr Val Ala Ser Thr Gly 
    290                 295                 300                 


Gly Thr Asp Thr Lys Ser Phe Ile Leu Val Arg Lys Ala Asp Met Ala 
305                 310                 315                 320 


Asp Ile Pro Gly His Val Phe Thr Arg Gly Met Ile Ile Ala Val Leu 
                325                 330                 335     


Ile Leu Val Ala Val Val Cys Leu Val Thr Val Cys Val Ile Tyr Arg 
            340                 345                 350         


Val Asp Leu Val Leu Phe Tyr Arg His Leu Thr Arg Arg Asp Glu Thr 
        355                 360                 365             


Leu Thr Asp Gly Lys Thr Tyr Asp Ala Phe Val Ser Tyr Leu Lys Glu 
    370                 375                 380                 


Cys Arg Pro Glu Asn Gly Glu Glu His Thr Phe Ala Val Glu Ile Leu 
385                 390                 395                 400 


Pro Arg Val Leu Glu Lys His Phe Gly Tyr Lys Leu Cys Ile Phe Glu 
                405                 410                 415     


Arg Asp Val Val Pro Gly Gly Ala Val Val Asp Glu Ile His Ser Leu 
            420                 425                 430         


Ile Glu Lys Ser Arg Arg Leu Ile Ile Val Leu Ser Lys Ser Tyr Met 
        435                 440                 445             


Ser Asn Glu Val Arg Tyr Glu Leu Glu Ser Gly Leu His Glu Ala Leu 
    450                 455                 460                 


Val Glu Arg Lys Ile Lys Ile Ile Leu Ile Glu Phe Thr Pro Val Thr 
465                 470                 475                 480 


Asp Phe Thr Phe Leu Pro Gln Ser Leu Lys Leu Leu Lys Ser His Arg 
                485                 490                 495     


Val Leu Lys Trp Lys Ala Asp Lys Ser Leu Ser Tyr Asn Ser Arg Phe 
            500                 505                 510         


Trp Lys Asn Leu Leu Tyr Leu Met Pro Ala Lys Thr Val Lys Pro Gly 
        515                 520                 525             


Arg Asp Glu Pro Glu Val Leu Pro Val Leu Ser Glu Ser 
    530                 535                 540     


<210>  14
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Glu Ser Cys Thr Ser Arg Pro His Ile Thr Val Val Glu Gly Glu 
1               5                   10                  15      


Pro Phe Tyr Leu Lys His Cys Ser Cys Ser Leu Ala His Glu Ile Glu 
            20                  25                  30          


Thr Thr Thr Lys Ser Trp Tyr Lys Ser Ser Gly Ser Gln Glu His Val 
        35                  40                  45              


Glu Leu Asn Pro Arg Ser Ser Ser Arg Ile Ala Leu His Asp Cys Val 
    50                  55                  60                  


Leu Glu Phe Trp Pro Val Glu Leu Asn Asp Thr Gly Ser Tyr Phe Phe 
65                  70                  75                  80  


Gln Met Lys Asn Tyr Thr Gln Lys Trp Lys Leu Asn Val Ile Arg Arg 
                85                  90                  95      


Asn Lys His Ser Cys Phe Thr Glu Arg Gln Val Thr Ser Lys Ile Val 
            100                 105                 110         


Glu Val Lys Lys Phe Phe Gln Ile Thr Cys Glu Asn Ser Tyr Tyr Gln 
        115                 120                 125             


Thr Leu Val Asn Ser Thr Ser Leu Tyr Lys Asn Cys Lys Lys Leu Leu 
    130                 135                 140                 


Leu Glu Asn Asn Lys Asn Pro Thr Ile Lys Lys Asn Ala Glu Phe Glu 
145                 150                 155                 160 


Asp Gln Gly Tyr Tyr Ser Cys Val His Phe Leu His His Asn Gly Lys 
                165                 170                 175     


Leu Phe Asn Ile Thr Lys Thr Phe Asn Ile Thr Ile Val Glu Asp Arg 
            180                 185                 190         


Ser Asn Ile Val Pro Val Leu Leu Gly Pro Lys Leu Asn His Val Ala 
        195                 200                 205             


Val Glu Leu Gly Lys Asn Val Arg Leu Asn Cys Ser Ala Leu Leu Asn 
    210                 215                 220                 


Glu Glu Asp Val Ile Tyr Trp Met Phe Gly Glu Glu Asn Gly Ser Asp 
225                 230                 235                 240 


Pro Asn Ile His Glu Glu Lys Glu Met Arg Ile Met Thr Pro Glu Gly 
                245                 250                 255     


Lys Trp His Ala Ser Lys Val Leu Arg Ile Glu Asn Ile Gly Glu Ser 
            260                 265                 270         


Asn Leu Asn Val Leu Tyr Asn Cys Thr Val Ala Ser Thr Gly Gly Thr 
        275                 280                 285             


Asp Thr Lys Ser Phe Ile Leu Val Arg Lys Ala Asp Met Ala Asp Ile 
    290                 295                 300                 


Pro Gly His Val Phe Thr Arg Gly Met Ile Ile Ala Val Leu Ile Leu 
305                 310                 315                 320 


Val Ala Val Val Cys Leu Val Thr Val Cys Val Ile Tyr Arg Val Asp 
                325                 330                 335     


Leu Val Leu Phe Tyr Arg His Leu Thr Arg Arg Asp Glu Thr Leu Thr 
            340                 345                 350         


Asp Gly Lys Thr Tyr Asp Ala Phe Val Ser Tyr Leu Lys Glu Cys Arg 
        355                 360                 365             


Pro Glu Asn Gly Glu Glu His Thr Phe Ala Val Glu Ile Leu Pro Arg 
    370                 375                 380                 


Val Leu Glu Lys His Phe Gly Tyr Lys Leu Cys Ile Phe Glu Arg Asp 
385                 390                 395                 400 


Val Val Pro Gly Gly Ala Val Val Asp Glu Ile His Ser Leu Ile Glu 
                405                 410                 415     


Lys Ser Arg Arg Leu Ile Ile Val Leu Ser Lys Ser Tyr Met Ser Asn 
            420                 425                 430         


Glu Val Arg Tyr Glu Leu Glu Ser Gly Leu His Glu Ala Leu Val Glu 
        435                 440                 445             


Arg Lys Ile Lys Ile Ile Leu Ile Glu Phe Thr Pro Val Thr Asp Phe 
    450                 455                 460                 


Thr Phe Leu Pro Gln Ser Leu Lys Leu Leu Lys Ser His Arg Val Leu 
465                 470                 475                 480 


Lys Trp Lys Ala Asp Lys Ser Leu Ser Tyr Asn Ser Arg Phe Trp Lys 
                485                 490                 495     


Asn Leu Leu Tyr Leu Met Pro Ala Lys Thr Val Lys Pro Gly Arg Asp 
            500                 505                 510         


Glu Pro Glu Val Leu Pro Val Leu Ser Glu Ser 
        515                 520             


<210>  15
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Leu Cys Leu Gly Trp Ile Phe Leu Trp Leu Val Ala Gly Glu Arg 
1               5                   10                  15      


Ile Lys Gly Phe Asn Ile Ser Gly Cys Ser Thr Lys Lys Leu Leu Trp 
            20                  25                  30          


Thr Tyr Ser Thr Arg Ser Glu Glu Glu Phe Val Leu Phe Cys Asp Leu 
        35                  40                  45              


Pro Glu Pro Gln Lys Ser His Phe Cys His Arg Asn Arg Leu Ser Pro 
    50                  55                  60                  


Lys Gln Val Pro Glu His Leu Pro Phe Met Gly Ser Asn Asp Leu Ser 
65                  70                  75                  80  


Asp Val Gln Trp Tyr Gln Gln Pro Ser Asn Gly Asp Pro Leu Glu Asp 
                85                  90                  95      


Ile Arg Lys Ser Tyr Pro His Ile Ile Gln Asp Lys Cys Thr Leu His 
            100                 105                 110         


Phe Leu Thr Pro Gly Val Asn Asn Ser Gly Ser Tyr Ile Cys Arg Pro 
        115                 120                 125             


Lys Met Ile Lys Ser Pro Tyr Asp Val Ala Cys Cys Val Lys Met Ile 
    130                 135                 140                 


Leu Glu Val Lys Pro Gln Thr Asn Ala Ser Cys Glu Tyr Ser Ala Ser 
145                 150                 155                 160 


His Lys Gln Asp Leu Leu Leu Gly Ser Thr Gly Ser Ile Ser Cys Pro 
                165                 170                 175     


Ser Leu Ser Cys Gln Ser Asp Ala Gln Ser Pro Ala Val Thr Trp Tyr 
            180                 185                 190         


Lys Asn Gly Lys Leu Leu Ser Val Glu Arg Ser Asn Arg Ile Val Val 
        195                 200                 205             


Asp Glu Val Tyr Asp Tyr His Gln Gly Thr Tyr Val Cys Asp Tyr Thr 
    210                 215                 220                 


Gln Ser Asp Thr Val Ser Ser Trp Thr Val Arg Ala Val Val Gln Val 
225                 230                 235                 240 


Arg Thr Ile Val Gly Asp Thr Lys Leu Lys Pro Asp Ile Leu Asp Pro 
                245                 250                 255     


Val Glu Asp Thr Leu Glu Val Glu Leu Gly Lys Pro Leu Thr Ile Ser 
            260                 265                 270         


Cys Lys Ala Arg Phe Gly Phe Glu Arg Val Phe Asn Pro Val Ile Lys 
        275                 280                 285             


Trp Tyr Ile Lys Asp Ser Asp Leu Glu Trp Glu Val Ser Val Pro Glu 
    290                 295                 300                 


Ala Lys Ser Ile Lys Ser Thr Leu Lys Asp Glu Ile Ile Glu Arg Asn 
305                 310                 315                 320 


Ile Ile Leu Glu Lys Val Thr Gln Arg Asp Leu Arg Arg Lys Phe Val 
                325                 330                 335     


Cys Phe Val Gln Asn Ser Ile Gly Asn Thr Thr Gln Ser Val Gln Leu 
            340                 345                 350         


Lys Glu Lys Arg Gly Val Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile 
        355                 360                 365             


Gly Thr Leu Val Ala Val Leu Ala Ala Ser Ala Leu Leu Tyr Arg His 
    370                 375                 380                 


Trp Ile Glu Ile Val Leu Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln 
385                 390                 395                 400 


Thr Leu Gly Asp Lys Lys Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys 
                405                 410                 415     


Trp Ser Ser Phe Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu Glu His 
            420                 425                 430         


Leu Ala Leu Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr 
        435                 440                 445             


Ser Leu Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val Tyr Ala 
    450                 455                 460                 


Glu Asp Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile 
465                 470                 475                 480 


Leu Ser Pro Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln Ala 
                485                 490                 495     


Ala Val Asn Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile Leu Ile 
            500                 505                 510         


Lys Phe Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His Leu Val Lys 
        515                 520                 525             


Lys Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg Gly Leu Lys Ser 
    530                 535                 540                 


Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met Arg Tyr His Met Pro 
545                 550                 555                 560 


Val Lys Asn Ser Gln Gly Phe Thr Trp Asn Gln Leu Arg Ile Thr Ser 
                565                 570                 575     


Arg Ile Phe Gln Trp Lys Gly Leu Ser Arg Thr Glu Thr Thr Gly Arg 
            580                 585                 590         


Ser Ser Gln Pro Lys Glu Trp 
        595                 


<210>  16
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  16

Phe Asn Ile Ser Gly Cys Ser Thr Lys Lys Leu Leu Trp Thr Tyr Ser 
1               5                   10                  15      


Thr Arg Ser Glu Glu Glu Phe Val Leu Phe Cys Asp Leu Pro Glu Pro 
            20                  25                  30          


Gln Lys Ser His Phe Cys His Arg Asn Arg Leu Ser Pro Lys Gln Val 
        35                  40                  45              


Pro Glu His Leu Pro Phe Met Gly Ser Asn Asp Leu Ser Asp Val Gln 
    50                  55                  60                  


Trp Tyr Gln Gln Pro Ser Asn Gly Asp Pro Leu Glu Asp Ile Arg Lys 
65                  70                  75                  80  


Ser Tyr Pro His Ile Ile Gln Asp Lys Cys Thr Leu His Phe Leu Thr 
                85                  90                  95      


Pro Gly Val Asn Asn Ser Gly Ser Tyr Ile Cys Arg Pro Lys Met Ile 
            100                 105                 110         


Lys Ser Pro Tyr Asp Val Ala Cys Cys Val Lys Met Ile Leu Glu Val 
        115                 120                 125             


Lys Pro Gln Thr Asn Ala Ser Cys Glu Tyr Ser Ala Ser His Lys Gln 
    130                 135                 140                 


Asp Leu Leu Leu Gly Ser Thr Gly Ser Ile Ser Cys Pro Ser Leu Ser 
145                 150                 155                 160 


Cys Gln Ser Asp Ala Gln Ser Pro Ala Val Thr Trp Tyr Lys Asn Gly 
                165                 170                 175     


Lys Leu Leu Ser Val Glu Arg Ser Asn Arg Ile Val Val Asp Glu Val 
            180                 185                 190         


Tyr Asp Tyr His Gln Gly Thr Tyr Val Cys Asp Tyr Thr Gln Ser Asp 
        195                 200                 205             


Thr Val Ser Ser Trp Thr Val Arg Ala Val Val Gln Val Arg Thr Ile 
    210                 215                 220                 


Val Gly Asp Thr Lys Leu Lys Pro Asp Ile Leu Asp Pro Val Glu Asp 
225                 230                 235                 240 


Thr Leu Glu Val Glu Leu Gly Lys Pro Leu Thr Ile Ser Cys Lys Ala 
                245                 250                 255     


Arg Phe Gly Phe Glu Arg Val Phe Asn Pro Val Ile Lys Trp Tyr Ile 
            260                 265                 270         


Lys Asp Ser Asp Leu Glu Trp Glu Val Ser Val Pro Glu Ala Lys Ser 
        275                 280                 285             


Ile Lys Ser Thr Leu Lys Asp Glu Ile Ile Glu Arg Asn Ile Ile Leu 
    290                 295                 300                 


Glu Lys Val Thr Gln Arg Asp Leu Arg Arg Lys Phe Val Cys Phe Val 
305                 310                 315                 320 


Gln Asn Ser Ile Gly Asn Thr Thr Gln Ser Val Gln Leu Lys Glu Lys 
                325                 330                 335     


Arg Gly Val Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile Gly Thr Leu 
            340                 345                 350         


Val Ala Val Leu Ala Ala Ser Ala Leu Leu Tyr Arg His Trp Ile Glu 
        355                 360                 365             


Ile Val Leu Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln Thr Leu Gly 
    370                 375                 380                 


Asp Lys Lys Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys Trp Ser Ser 
385                 390                 395                 400 


Phe Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu Glu His Leu Ala Leu 
                405                 410                 415     


Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr Ser Leu Cys 
            420                 425                 430         


Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val Tyr Ala Glu Asp Ile 
        435                 440                 445             


Val Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile Leu Ser Pro 
    450                 455                 460                 


Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln Ala Ala Val Asn 
465                 470                 475                 480 


Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile Leu Ile Lys Phe Cys 
                485                 490                 495     


Tyr Phe Gln Glu Pro Glu Ser Leu Pro His Leu Val Lys Lys Ala Leu 
            500                 505                 510         


Arg Val Leu Pro Thr Val Thr Trp Arg Gly Leu Lys Ser Val Pro Pro 
        515                 520                 525             


Asn Ser Arg Phe Trp Ala Lys Met Arg Tyr His Met Pro Val Lys Asn 
    530                 535                 540                 


Ser Gln Gly Phe Thr Trp Asn Gln Leu Arg Ile Thr Ser Arg Ile Phe 
545                 550                 555                 560 


Gln Trp Lys Gly Leu Ser Arg Thr Glu Thr Thr Gly Arg Ser Ser Gln 
                565                 570                 575     


Pro Lys Glu Trp 
            580 


<210>  17
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  18
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  19
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
        115                 120                 125             


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
    130                 135                 140                 


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
145                 150                 155                 160 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
                165                 170                 175     


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
            180                 185                 190         


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
        195                 200                 205             


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
    210                 215                 220                 


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
225                 230                 235                 240 


Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
                245                 250                 255     


Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
            260                 265                 270         


<210>  20
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  20

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln Val Ala Val Ala Gly 
    210                 215                 220                 


Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu Ser Gly Leu Thr Trp 
225                 230                 235                 240 


Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
                245                 250     


<210>  21
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          


Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 
    50                  55                  60                  


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
65                  70                  75                  80  


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
                85                  90                  95      


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
            100                 105                 110         


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
        115                 120                 125             


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
    130                 135                 140                 


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
145                 150                 155                 160 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
                165                 170                 175     


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
            180                 185                 190         


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
        195                 200                 205             


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
    210                 215                 220                 


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
225                 230                 235                 240 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250             


<210>  22
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  22

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210>  23
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  24
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  24

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210>  25
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Arg Met Leu Leu His Leu Ser Leu Leu Ala Leu Gly Ala Ala Tyr 
1               5                   10                  15      


Val Tyr Ala Ile Pro Thr Glu Ile Pro Thr Ser Ala Leu Val Lys Glu 
            20                  25                  30          


Thr Leu Ala Leu Leu Ser Thr His Arg Thr Leu Leu Ile Ala Asn Glu 
        35                  40                  45              


Thr Leu Arg Ile Pro Val Pro Val His Lys Asn His Gln Leu Cys Thr 
    50                  55                  60                  


Glu Glu Ile Phe Gln Gly Ile Gly Thr Leu Glu Ser Gln Thr Val Gln 
65                  70                  75                  80  


Gly Gly Thr Val Glu Arg Leu Phe Lys Asn Leu Ser Leu Ile Lys Lys 
                85                  90                  95      


Tyr Ile Asp Gly Gln Lys Lys Lys Cys Gly Glu Glu Arg Arg Arg Val 
            100                 105                 110         


Asn Gln Phe Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Met Asn Thr 
        115                 120                 125             


Glu Trp Ile Ile Glu Ser 
    130                 


<210>  26
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  26

Ile Pro Thr Glu Ile Pro Thr Ser Ala Leu Val Lys Glu Thr Leu Ala 
1               5                   10                  15      


Leu Leu Ser Thr His Arg Thr Leu Leu Ile Ala Asn Glu Thr Leu Arg 
            20                  25                  30          


Ile Pro Val Pro Val His Lys Asn His Gln Leu Cys Thr Glu Glu Ile 
        35                  40                  45              


Phe Gln Gly Ile Gly Thr Leu Glu Ser Gln Thr Val Gln Gly Gly Thr 
    50                  55                  60                  


Val Glu Arg Leu Phe Lys Asn Leu Ser Leu Ile Lys Lys Tyr Ile Asp 
65                  70                  75                  80  


Gly Gln Lys Lys Lys Cys Gly Glu Glu Arg Arg Arg Val Asn Gln Phe 
                85                  90                  95      


Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Met Asn Thr Glu Trp Ile 
            100                 105                 110         


Ile Glu Ser 
        115 


<210>  27
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  28
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  28

Val Pro Pro Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln 
1               5                   10                  15      


Pro Leu Thr Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu 
            20                  25                  30          


Asp Gly Ile Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met 
        35                  40                  45              


Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro 
    50                  55                  60                  


Lys Met Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu 
65                  70                  75                  80  


Thr Cys Leu Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr 
                85                  90                  95      


Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg 
            100                 105                 110         


Ala Val Gln Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys 
        115                 120                 125             


Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala 
    130                 135                 140                 


Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met 
145                 150                 155                 160 


Thr Thr His Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser 
                165                 170                 175     


Leu Arg Ala Leu Arg Gln Met 
            180             


<210>  29
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 
1               5                   10                  15      


Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 
            20                  25                  30          


Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 
        35                  40                  45              


Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 
    50                  55                  60                  


Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 
65                  70                  75                  80  


Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 
                85                  90                  95      


Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 
            100                 105                 110         


Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140                 


<210>  30
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  30

Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile 
1               5                   10                  15      


Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn 
            20                  25                  30          


Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg 
        35                  40                  45              


Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln 
    50                  55                  60                  


Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val 
65                  70                  75                  80  


Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn 
                85                  90                  95      


Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu 
            100                 105                 110         


Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
        115                 120                 125     


<210>  31
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  31

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  32
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  32

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


<210>  33
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
        115                 120                 125             


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
    130                 135                 140                 


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Ile 
            


<210>  34
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  34

Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     


<210>  35
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  36
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe Asn 
1               5                   10                  15      


Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly Ile 
            20                  25                  30          


Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser Gln 
        35                  40                  45              


Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp Gln 
    50                  55                  60                  


Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val Lys 
65                  70                  75                  80  


Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu Thr 
                85                  90                  95      


Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His Glu 
            100                 105                 110         


Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly Lys 
        115                 120                 125             


Arg Lys Arg Ser Gln Met Leu Phe Arg Gly Arg Arg Ala Ser Gln 
    130                 135                 140             


<210>  37
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  38
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  38

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210>  39
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Glu Ala Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  40
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  40

Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala Arg Asp 
1               5                   10                  15      


Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile Gly Ser 
            20                  25                  30          


Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys Arg Gly 
        35                  40                  45              


Pro Gly Gly Val Trp Ala Ala Glu Ala Ile Ser Asp Ala Arg Glu Asn 
    50                  55                  60                  


Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala Asp Gln 
65                  70                  75                  80  


Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His Phe Arg 
                85                  90                  95      


Pro Ala Gly Leu Pro Glu Lys Tyr 
            100                 


<210>  41
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Glu Lys Leu Leu Cys Phe Leu Val Leu Thr Ser Leu Ser His Ala 
1               5                   10                  15      


Phe Gly Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu 
            20                  25                  30          


Ser Asp Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu 
        35                  40                  45              


Lys Ala Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr 
    50                  55                  60                  


Arg Gly Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu 
65                  70                  75                  80  


Ile Leu Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly 
                85                  90                  95      


Gly Ser Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val 
            100                 105                 110         


His Ile Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp 
        115                 120                 125             


Val Asp Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr 
    130                 135                 140                 


Val Gly Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe 
145                 150                 155                 160 


Gly Gly Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn 
                165                 170                 175     


Val Asn Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile 
            180                 185                 190         


Tyr Leu Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu 
        195                 200                 205             


Lys Tyr Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro 
    210                 215                 220                 


<210>  42
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  42

Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu Ser Asp 
1               5                   10                  15      


Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu Lys Ala 
            20                  25                  30          


Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr Arg Gly 
        35                  40                  45              


Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu Ile Leu 
    50                  55                  60                  


Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly Gly Ser 
65                  70                  75                  80  


Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val His Ile 
                85                  90                  95      


Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp Val Asp 
            100                 105                 110         


Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr Val Gly 
        115                 120                 125             


Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe Gly Gly 
    130                 135                 140                 


Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn Val Asn 
145                 150                 155                 160 


Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile Tyr Leu 
                165                 170                 175     


Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu Lys Tyr 
            180                 185                 190         


Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro 
        195                 200                 205     


<210>  43
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Asp Gln Gln Ala Ile Tyr Ala Glu Leu Asn Leu Pro Thr Asp Ser 
1               5                   10                  15      


Gly Pro Glu Ser Ser Ser Pro Ser Ser Leu Pro Arg Asp Val Cys Gln 
            20                  25                  30          


Gly Ser Pro Trp His Gln Phe Ala Leu Lys Leu Ser Cys Ala Gly Ile 
        35                  40                  45              


Ile Leu Leu Val Leu Val Val Thr Gly Leu Ser Val Ser Val Thr Ser 
    50                  55                  60                  


Leu Ile Gln Lys Ser Ser Ile Glu Lys Cys Ser Val Asp Ile Gln Gln 
65                  70                  75                  80  


Ser Arg Asn Lys Thr Thr Glu Arg Pro Gly Leu Leu Asn Cys Pro Ile 
                85                  90                  95      


Tyr Trp Gln Gln Leu Arg Glu Lys Cys Leu Leu Phe Ser His Thr Val 
            100                 105                 110         


Asn Pro Trp Asn Asn Ser Leu Ala Asp Cys Ser Thr Lys Glu Ser Ser 
        115                 120                 125             


Leu Leu Leu Ile Arg Asp Lys Asp Glu Leu Ile His Thr Gln Asn Leu 
    130                 135                 140                 


Ile Arg Asp Lys Ala Ile Leu Phe Trp Ile Gly Leu Asn Phe Ser Leu 
145                 150                 155                 160 


Ser Glu Lys Asn Trp Lys Trp Ile Asn Gly Ser Phe Leu Asn Ser Asn 
                165                 170                 175     


Asp Leu Glu Ile Arg Gly Asp Ala Lys Glu Asn Ser Cys Ile Ser Ile 
            180                 185                 190         


Ser Gln Thr Ser Val Tyr Ser Glu Tyr Cys Ser Thr Glu Ile Arg Trp 
        195                 200                 205             


Ile Cys Gln Lys Glu Leu Thr Pro Val Arg Asn Lys Val Tyr Pro Asp 
    210                 215                 220                 


Ser 
225 


<210>  44
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Thr Leu Asp Gly His 
        355                 360                 365             


Met Val Val Arg Ser His Ala Arg Val Ser Ser Leu Thr Leu Lys Ser 
    370                 375                 380                 


Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr 
385                 390                 395                 400 


Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro 
                405                 410                 415     


Lys Leu Gln Gly Pro Val Ala Val Tyr Thr Trp Glu Gly Asn Gln Val 
            420                 425                 430         


Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp 
        435                 440                 445             


Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys 
    450                 455                 460                 


Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser 
465                 470                 475                 480 


Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly 
                485                 490                 495     


Gln Glu Ser Leu Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser 
            500                 505                 510         


Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln 
        515                 520                 525             


Phe Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys 
    530                 535                 540                 


Ala Glu Trp Arg Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr 
545                 550                 555                 560 


Asp Ala Lys Glu Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu 
                565                 570                 575     


Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys 
            580                 585                 590         


Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val 
        595                 600                 605             


Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp 
    610                 615                 620                 


Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser 
625                 630                 635                 640 


Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp 
                645                 650                 655     


Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu Lys 
            660                 665                 670         


Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn 
        675                 680                 685             


Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala 
    690                 695                 700                 


Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser 
705                 710                 715                 720 


Thr Gly Ala Ile Val Gly Ile Leu Ile Val Ile Phe Val Leu Leu Leu 
                725                 730                 735     


Val Val Val Asp Ile Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe 
            740                 745                 750         


Met Cys Ile Ala Val Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys 
        755                 760                 765             


Gly Lys Asp Met Glu Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser 
    770                 775                 780                 


Lys Glu Pro Ile Val Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn 
785                 790                 795                 800 


His Asp Gly Gly Lys His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr 
                805                 810                 815     


Glu Pro Glu Lys Gly Pro Val Glu Ala Lys Pro Glu Cys Gln Glu Thr 
            820                 825                 830         


Glu Thr Lys Pro Ala Pro Ala Glu Val Lys Thr Val Pro Asn Asp Ala 
        835                 840                 845             


Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
    850                 855             


<210>  45
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  45

Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser Val Gly Glu 
1               5                   10                  15      


Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys Asp Lys Asp 
            20                  25                  30          


Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro Asn Gln Gln 
        35                  40                  45              


Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr Leu Thr Ile 
    50                  55                  60                  


Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys Val Val Thr 
65                  70                  75                  80  


Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val Lys Ile Phe 
                85                  90                  95      


Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu Phe Arg Glu 
            100                 105                 110         


Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser Leu Pro Pro 
        115                 120                 125             


Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu Lys Lys Asp 
    130                 135                 140                 


Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile Arg Gly Ile 
145                 150                 155                 160 


Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg Ile Leu Ala 
                165                 170                 175     


Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val Asn Val Pro 
            180                 185                 190         


Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr Ala Asn Leu 
        195                 200                 205             


Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe Pro Glu Pro 
    210                 215                 220                 


Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln Glu Glu Asp 
225                 230                 235                 240 


Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu Thr Ile Lys 
                245                 250                 255     


Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile Ala Glu Asn 
            260                 265                 270         


Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val Phe Ala Lys 
        275                 280                 285             


Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu Leu Glu Glu 
    290                 295                 300                 


Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile Pro Ser Ile 
305                 310                 315                 320 


Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu Lys Ala Ser 
                325                 330                 335     


Trp Thr Arg Pro Glu Lys Gln Glu Thr Leu Asp Gly His Met Val Val 
            340                 345                 350         


Arg Ser His Ala Arg Val Ser Ser Leu Thr Leu Lys Ser Ile Gln Tyr 
        355                 360                 365             


Thr Asp Ala Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr Ile Gly Gln 
    370                 375                 380                 


Asp Ser Gln Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro Lys Leu Gln 
385                 390                 395                 400 


Gly Pro Val Ala Val Tyr Thr Trp Glu Gly Asn Gln Val Asn Ile Thr 
                405                 410                 415     


Cys Glu Val Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp Phe Arg Asp 
            420                 425                 430         


Gly Gln Leu Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys Ile Tyr Asn 
        435                 440                 445             


Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser Glu Asn Asp 
    450                 455                 460                 


Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly Gln Glu Ser 
465                 470                 475                 480 


Leu Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser Pro Ser Ile 
                485                 490                 495     


Asp Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln Phe Asp Glu 
            500                 505                 510         


Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys Ala Glu Trp 
        515                 520                 525             


Arg Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr Asp Ala Lys 
    530                 535                 540                 


Glu Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu Lys Pro Glu 
545                 550                 555                 560 


Thr Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys Gly Leu Gly 
                565                 570                 575     


Glu Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val Gln Gly Glu 
            580                 585                 590         


Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser 
        595                 600                 605             


Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg 
    610                 615                 620                 


His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu 
625                 630                 635                 640 


Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp 
                645                 650                 655     


Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly 
            660                 665                 670         


Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr 
        675                 680                 685             


Ala Ile Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser Thr Gly Ala 
    690                 695                 700                 


Ile Val Gly Ile Leu Ile Val Ile Phe Val Leu Leu Leu Val Val Val 
705                 710                 715                 720 


Asp Ile Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe Met Cys Ile 
                725                 730                 735     


Ala Val Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys Gly Lys Asp 
            740                 745                 750         


Met Glu Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser Lys Glu Pro 
        755                 760                 765             


Ile Val Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn His Asp Gly 
    770                 775                 780                 


Gly Lys His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr Glu Pro Glu 
785                 790                 795                 800 


Lys Gly Pro Val Glu Ala Lys Pro Glu Cys Gln Glu Thr Glu Thr Lys 
                805                 810                 815     


Pro Ala Pro Ala Glu Val Lys Thr Val Pro Asn Asp Ala Thr Gln Thr 
            820                 825                 830         


Lys Glu Asn Glu Ser Lys Ala 
        835                 


<210>  46
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  46
atggctgctg aaccagtaga agacaattgc atcaactttg tggcaatgaa atttattgac       60

aatacgcttt actttatagc tgaagatgat gaaaacctgg aatcagatta ctttggcaag      120

cttgaatcta aattatcagt cataagaaat ttgaatgacc aagttctctt cattgaccaa      180

ggaaatcggc ctctatttga agatatgact gattctgact gtagagataa tgcaccccgg      240

accatattta ttataagtat gtataaagat agccagccta gaggtatggc tgtaactatc      300

tctgtgaagt gtgagaaaat ttcaactctc tcctgtgaga acaaaattat ttcctttaag      360

gaaatgaatc ctcctgataa catcaaggat acaaaaagtg acatcatatt ctttcagaga      420

agtgtcccag gacatgataa taagatgcaa tttgaatctt catcatacga aggatacttt      480

ctagcttgtg aaaaagagag agaccttttt aaactcattt tgaaaaaaga ggatgaattg      540

ggggatagat ctataatgtt cactgttcaa aacgaagact ag                         582


<210>  47
<211>  474
<212>  DNA
<213>  Homo sapiens

<400>  47
tactttggca agcttgaatc taaattatca gtcataagaa atttgaatga ccaagttctc       60

ttcattgacc aaggaaatcg gcctctattt gaagatatga ctgattctga ctgtagagat      120

aatgcacccc ggaccatatt tattataagt atgtataaag atagccagcc tagaggtatg      180

gctgtaacta tctctgtgaa gtgtgagaaa atttcaactc tctcctgtga gaacaaaatt      240

atttccttta aggaaatgaa tcctcctgat aacatcaagg atacaaaaag tgacatcata      300

ttctttcaga gaagtgtccc aggacatgat aataagatgc aatttgaatc ttcatcatac      360

gaaggatact ttctagcttg tgaaaaagag agagaccttt ttaaactcat tttgaaaaaa      420

gaggatgaat tgggggatag atctataatg ttcactgttc aaaacgaaga ctag            474


<210>  48
<211>  585
<212>  DNA
<213>  Homo sapiens

<400>  48
atgaccatga gacacaactg gacaccagac ctcagccctt tgtgggtcct gctcctgtgt       60

gcccacgtcg tcactctcct ggtcagagcc acacctgtct cgcagaccac cacagctgcc      120

actgcctcag ttagaagcac aaaggacccc tgcccctccc agcccccagt gttcccagca      180

gctaagcagt gtccagcatt ggaagtgacc tggccagagg tggaagtgcc actgaatgga      240

acgctgagct tatcctgtgt ggcctgcagc cgcttcccca acttcagcat cctctactgg      300

ctgggcaatg gttccttcat tgagcacctc ccaggccgac tgtgggaggg gagcaccagc      360

cgggaacgtg ggagcacagg tacgcagctg tgcaaggcct tggtgctgga gcagctgacc      420

cctgccctgc acagcaccaa cttctcctgt gtgctcgtgg accctgaaca ggttgtccag      480

cgtcacgtcg tcctggccca gctctgggct gggctgaggg caaccttgcc ccccacccaa      540

gaagccctgc cctccagcca cagcagtcca cagcagcagg gttaa                      585


<210>  49
<211>  495
<212>  DNA
<213>  Homo sapiens

<400>  49
acacctgtct cgcagaccac cacagctgcc actgcctcag ttagaagcac aaaggacccc       60

tgcccctccc agcccccagt gttcccagca gctaagcagt gtccagcatt ggaagtgacc      120

tggccagagg tggaagtgcc actgaatgga acgctgagct tatcctgtgt ggcctgcagc      180

cgcttcccca acttcagcat cctctactgg ctgggcaatg gttccttcat tgagcacctc      240

ccaggccgac tgtgggaggg gagcaccagc cgggaacgtg ggagcacagg tacgcagctg      300

tgcaaggcct tggtgctgga gcagctgacc cctgccctgc acagcaccaa cttctcctgt      360

gtgctcgtgg accctgaaca ggttgtccag cgtcacgtcg tcctggccca gctctgggct      420

gggctgaggg caaccttgcc ccccacccaa gaagccctgc cctccagcca cagcagtcca      480

cagcagcagg gttaa                                                       495


<210>  50
<211>  1626
<212>  DNA
<213>  Homo sapiens

<400>  50
atgaattgta gagaattacc cttgaccctt tgggtgctta tatctgtaag cactgcagaa       60

tcttgtactt cacgtcccca cattactgtg gttgaagggg aacctttcta tctgaaacat      120

tgctcgtgtt cacttgcaca tgagattgaa acaaccacca aaagctggta caaaagcagt      180

ggatcacagg aacatgtgga gctgaaccca aggagttcct cgagaattgc tttgcatgat      240

tgtgttttgg agttttggcc agttgagttg aatgacacag gatcttactt tttccaaatg      300

aaaaattata ctcagaaatg gaaattaaat gtcatcagaa gaaataaaca cagctgtttc      360

actgaaagac aagtaactag taaaattgtg gaagttaaaa aattttttca gataacctgt      420

gaaaacagtt actatcaaac actggtcaac agcacatcat tgtataagaa ctgtaaaaag      480

ctactactgg agaacaataa aaacccaacg ataaagaaga acgccgagtt tgaagatcag      540

gggtattact cctgcgtgca tttccttcat cataatggaa aactatttaa tatcaccaaa      600

accttcaata taacaatagt ggaagatcgc agtaatatag ttccggttct tcttggacca      660

aagcttaacc atgttgcagt ggaattagga aaaaacgtaa ggctcaactg ctctgctttg      720

ctgaatgaag aggatgtaat ttattggatg ttcggggaag aaaatggatc ggatcctaat      780

atacatgaag agaaagaaat gagaattatg actccagaag gcaaatggca tgcttcaaaa      840

gtattgagaa ttgaaaatat tggtgaaagc aatctaaatg ttttatataa ttgcactgtg      900

gccagcacgg gaggcacaga caccaaaagc ttcatcttgg tgagaaaagc agacatggct      960

gatatcccag gccacgtctt cacaagagga atgatcatag ctgttttgat cttggtggca     1020

gtagtgtgcc tagtgactgt gtgtgtcatt tatagagttg acttggttct attttataga     1080

catttaacga gaagagatga aacattaaca gatggaaaaa catatgatgc ttttgtgtct     1140

tacctaaaag aatgccgacc tgaaaatgga gaggagcaca cctttgctgt ggagattttg     1200

cccagggtgt tggagaaaca ttttgggtat aagttatgca tatttgaaag ggatgtagtg     1260

cctggaggag ctgttgttga tgaaatccac tcactgatag agaaaagccg aagactaatc     1320

attgtcctaa gtaaaagtta tatgtctaat gaggtcaggt atgaacttga aagtggactc     1380

catgaagcat tggtggaaag aaaaattaaa ataatcttaa ttgaatttac acctgttact     1440

gacttcacat tcttgcccca atcactaaag cttttgaaat ctcacagagt tctgaagtgg     1500

aaggccgata aatctctttc ttataactca aggttctgga agaaccttct ttacttaatg     1560

cctgcaaaaa cagtcaagcc aggtagagac gaaccggaag tcttgcctgt tctttccgag     1620

tcttaa                                                                1626


<210>  51
<211>  1572
<212>  DNA
<213>  Homo sapiens

<400>  51
gcagaatctt gtacttcacg tccccacatt actgtggttg aaggggaacc tttctatctg       60

aaacattgct cgtgttcact tgcacatgag attgaaacaa ccaccaaaag ctggtacaaa      120

agcagtggat cacaggaaca tgtggagctg aacccaagga gttcctcgag aattgctttg      180

catgattgtg ttttggagtt ttggccagtt gagttgaatg acacaggatc ttactttttc      240

caaatgaaaa attatactca gaaatggaaa ttaaatgtca tcagaagaaa taaacacagc      300

tgtttcactg aaagacaagt aactagtaaa attgtggaag ttaaaaaatt ttttcagata      360

acctgtgaaa acagttacta tcaaacactg gtcaacagca catcattgta taagaactgt      420

aaaaagctac tactggagaa caataaaaac ccaacgataa agaagaacgc cgagtttgaa      480

gatcaggggt attactcctg cgtgcatttc cttcatcata atggaaaact atttaatatc      540

accaaaacct tcaatataac aatagtggaa gatcgcagta atatagttcc ggttcttctt      600

ggaccaaagc ttaaccatgt tgcagtggaa ttaggaaaaa acgtaaggct caactgctct      660

gctttgctga atgaagagga tgtaatttat tggatgttcg gggaagaaaa tggatcggat      720

cctaatatac atgaagagaa agaaatgaga attatgactc cagaaggcaa atggcatgct      780

tcaaaagtat tgagaattga aaatattggt gaaagcaatc taaatgtttt atataattgc      840

actgtggcca gcacgggagg cacagacacc aaaagcttca tcttggtgag aaaagcagac      900

atggctgata tcccaggcca cgtcttcaca agaggaatga tcatagctgt tttgatcttg      960

gtggcagtag tgtgcctagt gactgtgtgt gtcatttata gagttgactt ggttctattt     1020

tatagacatt taacgagaag agatgaaaca ttaacagatg gaaaaacata tgatgctttt     1080

gtgtcttacc taaaagaatg ccgacctgaa aatggagagg agcacacctt tgctgtggag     1140

attttgccca gggtgttgga gaaacatttt gggtataagt tatgcatatt tgaaagggat     1200

gtagtgcctg gaggagctgt tgttgatgaa atccactcac tgatagagaa aagccgaaga     1260

ctaatcattg tcctaagtaa aagttatatg tctaatgagg tcaggtatga acttgaaagt     1320

ggactccatg aagcattggt ggaaagaaaa attaaaataa tcttaattga atttacacct     1380

gttactgact tcacattctt gccccaatca ctaaagcttt tgaaatctca cagagttctg     1440

aagtggaagg ccgataaatc tctttcttat aactcaaggt tctggaagaa ccttctttac     1500

ttaatgcctg caaaaacagt caagccaggt agagacgaac cggaagtctt gcctgttctt     1560

tccgagtctt aa                                                         1572


<210>  52
<211>  1800
<212>  DNA
<213>  Homo sapiens

<400>  52
atgctctgtt tgggctggat atttctttgg cttgttgcag gagagcgaat taaaggattt       60

aatatttcag gttgttccac aaaaaaactc ctttggacat attctacaag gagtgaagag      120

gaatttgtct tattttgtga tttaccagag ccacagaaat cacatttctg ccacagaaat      180

cgactctcac caaaacaagt ccctgagcac ctgcccttca tgggtagtaa cgacctatct      240

gatgtccaat ggtaccaaca accttcgaat ggagatccat tagaggacat taggaaaagc      300

tatcctcaca tcattcagga caaatgtacc cttcactttt tgaccccagg ggtgaataat      360

tctgggtcat atatttgtag acccaagatg attaagagcc cctatgatgt agcctgttgt      420

gtcaagatga ttttagaagt taagccccag acaaatgcat cctgtgagta ttccgcatca      480

cataagcaag acctacttct tgggagcact ggctctattt cttgccccag tctcagctgc      540

caaagtgatg cacaaagtcc agcggtaacc tggtacaaga atggaaaact cctctctgtg      600

gaaaggagca accgaatcgt agtggatgaa gtttatgact atcaccaggg cacatatgta      660

tgtgattaca ctcagtcgga tactgtgagt tcgtggacag tcagagctgt tgttcaagtg      720

agaaccattg tgggagacac taaactcaaa ccagatattc tggatcctgt cgaggacaca      780

ctggaagtag aacttggaaa gcctttaact attagctgca aagcacgatt tggctttgaa      840

agggtcttta accctgtcat aaaatggtac atcaaagatt ctgacctaga gtgggaagtc      900

tcagtacctg aggcgaaaag tattaaatcc actttaaagg atgaaatcat tgagcgtaat      960

atcatcttgg aaaaagtcac tcagcgtgat cttcgcagga agtttgtttg ctttgtccag     1020

aactccattg gaaacacaac ccagtccgtc caactgaaag aaaagagagg agtggtgctc     1080

ctgtacatcc tgcttggcac catcgggacc ctggtggccg tgctggcggc gagtgccctc     1140

ctctacaggc actggattga aatagtgctg ctgtaccgga cctaccagag caaggatcag     1200

acgcttgggg ataaaaagga ttttgatgct ttcgtatcct atgcaaaatg gagctctttt     1260

ccaagtgagg ccacttcatc tctgagtgaa gaacacttgg ccctgagcct atttcctgat     1320

gttttagaaa acaaatatgg atatagcctg tgtttgcttg aaagagatgt ggctccagga     1380

ggagtgtatg cagaagacat tgtgagcatt attaagagaa gcagaagagg aatatttatc     1440

ttgagcccca actatgtcaa tggacccagt atctttgaac tacaagcagc agtgaatctt     1500

gccttggatg atcaaacact gaaactcatt ttaattaagt tctgttactt ccaagagcca     1560

gagtctctac ctcatctcgt gaaaaaagct ctcagggttt tgcccacagt tacttggaga     1620

ggcttaaaat cagttcctcc caattctagg ttctgggcca aaatgcgcta ccacatgcct     1680

gtgaaaaact ctcagggatt cacgtggaac cagctcagaa ttacctctag gatttttcag     1740

tggaaaggac tcagtagaac agaaaccact gggaggagct cccagcctaa ggaatggtga     1800


<210>  53
<211>  1743
<212>  DNA
<213>  Homo sapiens

<400>  53
tttaatattt caggttgttc cacaaaaaaa ctcctttgga catattctac aaggagtgaa       60

gaggaatttg tcttattttg tgatttacca gagccacaga aatcacattt ctgccacaga      120

aatcgactct caccaaaaca agtccctgag cacctgccct tcatgggtag taacgaccta      180

tctgatgtcc aatggtacca acaaccttcg aatggagatc cattagagga cattaggaaa      240

agctatcctc acatcattca ggacaaatgt acccttcact ttttgacccc aggggtgaat      300

aattctgggt catatatttg tagacccaag atgattaaga gcccctatga tgtagcctgt      360

tgtgtcaaga tgattttaga agttaagccc cagacaaatg catcctgtga gtattccgca      420

tcacataagc aagacctact tcttgggagc actggctcta tttcttgccc cagtctcagc      480

tgccaaagtg atgcacaaag tccagcggta acctggtaca agaatggaaa actcctctct      540

gtggaaagga gcaaccgaat cgtagtggat gaagtttatg actatcacca gggcacatat      600

gtatgtgatt acactcagtc ggatactgtg agttcgtgga cagtcagagc tgttgttcaa      660

gtgagaacca ttgtgggaga cactaaactc aaaccagata ttctggatcc tgtcgaggac      720

acactggaag tagaacttgg aaagccttta actattagct gcaaagcacg atttggcttt      780

gaaagggtct ttaaccctgt cataaaatgg tacatcaaag attctgacct agagtgggaa      840

gtctcagtac ctgaggcgaa aagtattaaa tccactttaa aggatgaaat cattgagcgt      900

aatatcatct tggaaaaagt cactcagcgt gatcttcgca ggaagtttgt ttgctttgtc      960

cagaactcca ttggaaacac aacccagtcc gtccaactga aagaaaagag aggagtggtg     1020

ctcctgtaca tcctgcttgg caccatcggg accctggtgg ccgtgctggc ggcgagtgcc     1080

ctcctctaca ggcactggat tgaaatagtg ctgctgtacc ggacctacca gagcaaggat     1140

cagacgcttg gggataaaaa ggattttgat gctttcgtat cctatgcaaa atggagctct     1200

tttccaagtg aggccacttc atctctgagt gaagaacact tggccctgag cctatttcct     1260

gatgttttag aaaacaaata tggatatagc ctgtgtttgc ttgaaagaga tgtggctcca     1320

ggaggagtgt atgcagaaga cattgtgagc attattaaga gaagcagaag aggaatattt     1380

atcttgagcc ccaactatgt caatggaccc agtatctttg aactacaagc agcagtgaat     1440

cttgccttgg atgatcaaac actgaaactc attttaatta agttctgtta cttccaagag     1500

ccagagtctc tacctcatct cgtgaaaaaa gctctcaggg ttttgcccac agttacttgg     1560

agaggcttaa aatcagttcc tcccaattct aggttctggg ccaaaatgcg ctaccacatg     1620

cctgtgaaaa actctcaggg attcacgtgg aaccagctca gaattacctc taggattttt     1680

cagtggaaag gactcagtag aacagaaacc actgggagga gctcccagcc taaggaatgg     1740

tga                                                                   1743


<210>  54
<211>  462
<212>  DNA
<213>  Homo sapiens

<400>  54
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactt ga                         462


<210>  55
<211>  402
<212>  DNA
<213>  Homo sapiens

<400>  55
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat       60

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      120

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      180

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      240

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      300

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      360

tggattacct tttgtcaaag catcatctca acactgactt ga                         402


<210>  56
<211>  819
<212>  DNA
<213>  Homo sapiens

<400>  56
atggattcat acctgctgat gtggggactg ctcacgttca tcatggtgcc tggctgccag       60

gcagagctct gtgacgatga cccgccagag atcccacacg ccacattcaa agccatggcc      120

tacaaggaag gaaccatgtt gaactgtgaa tgcaagagag gtttccgcag aataaaaagc      180

gggtcactct atatgctctg tacaggaaac tctagccact cgtcctggga caaccaatgt      240

caatgcacaa gctctgccac tcggaacaca acgaaacaag tgacacctca acctgaagaa      300

cagaaagaaa ggaaaaccac agaaatgcaa agtccaatgc agccagtgga ccaagcgagc      360

cttccaggtc actgcaggga acctccacca tgggaaaatg aagccacaga gagaatttat      420

catttcgtgg tggggcagat ggtttattat cagtgcgtcc agggatacag ggctctacac      480

agaggtcctg ctgagagcgt ctgcaaaatg acccacggga agacaaggtg gacccagccc      540

cagctcatat gcacaggtga aatggagacc agtcagtttc caggtgaaga gaagcctcag      600

gcaagccccg aaggccgtcc tgagagtgag acttcctgcc tcgtcacaac aacagatttt      660

caaatacaga cagaaatggc tgcaaccatg gagacgtcca tatttacaac agagtaccag      720

gtagcagtgg ccggctgtgt tttcctgctg atcagcgtcc tcctcctgag tgggctcacc      780

tggcagcgga gacagaggaa gagtagaaga acaatctag                             819


<210>  57
<211>  756
<212>  DNA
<213>  Homo sapiens

<400>  57
gagctctgtg acgatgaccc gccagagatc ccacacgcca cattcaaagc catggcctac       60

aaggaaggaa ccatgttgaa ctgtgaatgc aagagaggtt tccgcagaat aaaaagcggg      120

tcactctata tgctctgtac aggaaactct agccactcgt cctgggacaa ccaatgtcaa      180

tgcacaagct ctgccactcg gaacacaacg aaacaagtga cacctcaacc tgaagaacag      240

aaagaaagga aaaccacaga aatgcaaagt ccaatgcagc cagtggacca agcgagcctt      300

ccaggtcact gcagggaacc tccaccatgg gaaaatgaag ccacagagag aatttatcat      360

ttcgtggtgg ggcagatggt ttattatcag tgcgtccagg gatacagggc tctacacaga      420

ggtcctgctg agagcgtctg caaaatgacc cacgggaaga caaggtggac ccagccccag      480

ctcatatgca caggtgaaat ggagaccagt cagtttccag gtgaagagaa gcctcaggca      540

agccccgaag gccgtcctga gagtgagact tcctgcctcg tcacaacaac agattttcaa      600

atacagacag aaatggctgc aaccatggag acgtccatat ttacaacaga gtaccaggta      660

gcagtggccg gctgtgtttt cctgctgatc agcgtcctcc tcctgagtgg gctcacctgg      720

cagcggagac agaggaagag tagaagaaca atctag                                756


<210>  58
<211>  762
<212>  DNA
<213>  Homo sapiens

<400>  58
atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg       60

catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc      120

ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc      180

gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg      240

gccgtcagca acatgctcca gaaggccaga caaactctag aattttaccc ttgcacttct      300

gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta      360

ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact      420

aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt      480

atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg      540

atggatccta agaggcagat ctttctagat caaaacatgc tggcagttat tgatgagctg      600

atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg      660

gatttttata aaactaaaat caagctctgc atacttcttc atgctttcag aattcgggca      720

gtgactattg atagagtgat gagctatctg aatgcttcct aa                         762


<210>  59
<211>  594
<212>  DNA
<213>  Homo sapiens

<400>  59
agaaacctcc ccgtggccac tccagaccca ggaatgttcc catgccttca ccactcccaa       60

aacctgctga gggccgtcag caacatgctc cagaaggcca gacaaactct agaattttac      120

ccttgcactt ctgaagagat tgatcatgaa gatatcacaa aagataaaac cagcacagtg      180

gaggcctgtt taccattgga attaaccaag aatgagagtt gcctaaattc cagagagacc      240

tctttcataa ctaatgggag ttgcctggcc tccagaaaga cctcttttat gatggccctg      300

tgccttagta gtatttatga agacttgaag atgtaccagg tggagttcaa gaccatgaat      360

gcaaagcttc tgatggatcc taagaggcag atctttctag atcaaaacat gctggcagtt      420

attgatgagc tgatgcaggc cctgaatttc aacagtgaga ctgtgccaca aaaatcctcc      480

cttgaagaac cggattttta taaaactaaa atcaagctct gcatacttct tcatgctttc      540

agaattcggg cagtgactat tgatagagtg atgagctatc tgaatgcttc ctaa            594


<210>  60
<211>  987
<212>  DNA
<213>  Homo sapiens

<400>  60
atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc       60

gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat      120

gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg      180

accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa      240

gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg      300

ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag      360

aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc      420

acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga      480

ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc      540

agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca      600

gctgctgagg agagtctgcc cattgaggtc atggtggatg ccgttcacaa gctcaagtat      660

gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac      720

ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac      780

acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaggt ccagggcaag      840

agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc      900

cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc      960

gaatgggcat ctgtgccctg cagttag                                          987


<210>  61
<211>  921
<212>  DNA
<213>  Homo sapiens

<400>  61
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtta g                                                921


<210>  62
<211>  405
<212>  DNA
<213>  Homo sapiens

<400>  62
atgaggatgc ttctgcattt gagtttgcta gctcttggag ctgcctacgt gtatgccatc       60

cccacagaaa ttcccacaag tgcattggtg aaagagacct tggcactgct ttctactcat      120

cgaactctgc tgatagccaa tgagactctg aggattcctg ttcctgtaca taaaaatcac      180

caactgtgca ctgaagaaat ctttcaggga ataggcacac tggagagtca aactgtgcaa      240

gggggtactg tggaaagact attcaaaaac ttgtccttaa taaagaaata cattgacggc      300

caaaaaaaaa agtgtggaga agaaagacgg agagtaaacc aattcctaga ctacctgcaa      360

gagtttcttg gtgtaatgaa caccgagtgg ataatagaaa gttga                      405


<210>  63
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  63
atccccacag aaattcccac aagtgcattg gtgaaagaga ccttggcact gctttctact       60

catcgaactc tgctgatagc caatgagact ctgaggattc ctgttcctgt acataaaaat      120

caccaactgt gcactgaaga aatctttcag ggaataggca cactggagag tcaaactgtg      180

caagggggta ctgtggaaag actattcaaa aacttgtcct taataaagaa atacattgac      240

ggccaaaaaa aaaagtgtgg agaagaaaga cggagagtaa accaattcct agactacctg      300

caagagtttc ttggtgtaat gaacaccgag tggataatag aaagttga                   348


<210>  64
<211>  639
<212>  DNA
<213>  Homo sapiens

<400>  64
atgaactcct tctccacaag cgccttcggt ccagttgcct tctccctggg gctgctcctg       60

gtgttgcctg ctgccttccc tgccccagta cccccaggag aagattccaa agatgtagcc      120

gccccacaca gacagccact cacctcttca gaacgaattg acaaacaaat tcggtacatc      180

ctcgacggca tctcagccct gagaaaggag acatgtaaca agagtaacat gtgtgaaagc      240

agcaaagagg cactggcaga aaacaacctg aaccttccaa agatggctga aaaagatgga      300

tgcttccaat ctggattcaa tgaggagact tgcctggtga aaatcatcac tggtcttttg      360

gagtttgagg tatacctaga gtacctccag aacagatttg agagtagtga ggaacaagcc      420

agagctgtgc agatgagtac aaaagtcctg atccagttcc tgcagaaaaa ggcaaagaat      480

ctagatgcaa taaccacccc tgacccaacc acaaatgcca gcctgctgac gaagctgcag      540

gcacagaacc agtggctgca ggacatgaca actcatctca ttctgcgcag ctttaaggag      600

ttcctgcagt ccagcctgag ggctcttcgg caaatgtag                             639


<210>  65
<211>  552
<212>  DNA
<213>  Homo sapiens

<400>  65
gtacccccag gagaagattc caaagatgta gccgccccac acagacagcc actcacctct       60

tcagaacgaa ttgacaaaca aattcggtac atcctcgacg gcatctcagc cctgagaaag      120

gagacatgta acaagagtaa catgtgtgaa agcagcaaag aggcactggc agaaaacaac      180

ctgaaccttc caaagatggc tgaaaaagat ggatgcttcc aatctggatt caatgaggag      240

acttgcctgg tgaaaatcat cactggtctt ttggagtttg aggtatacct agagtacctc      300

cagaacagat ttgagagtag tgaggaacaa gccagagctg tgcagatgag tacaaaagtc      360

ctgatccagt tcctgcagaa aaaggcaaag aatctagatg caataaccac ccctgaccca      420

accacaaatg ccagcctgct gacgaagctg caggcacaga accagtggct gcaggacatg      480

acaactcatc tcattctgcg cagctttaag gagttcctgc agtccagcct gagggctctt      540

cggcaaatgt ag                                                          552


<210>  66
<211>  435
<212>  DNA
<213>  Homo sapiens

<400>  66
atgcttctgg ccatggtcct tacctctgcc ctgctcctgt gctccgtggc aggccagggg       60

tgtccaacct tggcggggat cctggacatc aacttcctca tcaacaagat gcaggaagat      120

ccagcttcca agtgccactg cagtgctaat gtgaccagtt gtctctgttt gggcattccc      180

tctgacaact gcaccagacc atgcttcagt gagagactgt ctcagatgac caataccacc      240

atgcaaacaa gatacccact gattttcagt cgggtgaaaa aatcagttga agtactaaag      300

aacaacaagt gtccatattt ttcctgtgaa cagccatgca accaaaccac ggcaggcaac      360

gcgctgacat ttctgaagag tcttctggaa attttccaga aagaaaagat gagagggatg      420

agaggcaaga tatga                                                       435


<210>  67
<211>  381
<212>  DNA
<213>  Homo sapiens

<400>  67
caggggtgtc caaccttggc ggggatcctg gacatcaact tcctcatcaa caagatgcag       60

gaagatccag cttccaagtg ccactgcagt gctaatgtga ccagttgtct ctgtttgggc      120

attccctctg acaactgcac cagaccatgc ttcagtgaga gactgtctca gatgaccaat      180

accaccatgc aaacaagata cccactgatt ttcagtcggg tgaaaaaatc agttgaagta      240

ctaaagaaca acaagtgtcc atatttttcc tgtgaacagc catgcaacca aaccacggca      300

ggcaacgcgc tgacatttct gaagagtctt ctggaaattt tccagaaaga aaagatgaga      360

gggatgagag gcaagatatg a                                                381


<210>  68
<211>  537
<212>  DNA
<213>  Homo sapiens

<400>  68
atgcacagct cagcactgct ctgttgcctg gtcctcctga ctggggtgag ggccagccca       60

ggccagggca cccagtctga gaacagctgc acccacttcc caggcaacct gcctaacatg      120

cttcgagatc tccgagatgc cttcagcaga gtgaagactt tctttcaaat gaaggatcag      180

ctggacaact tgttgttaaa ggagtccttg ctggaggact ttaagggtta cctgggttgc      240

caagccttgt ctgagatgat ccagttttac ctggaggagg tgatgcccca agctgagaac      300

caagacccag acatcaaggc gcatgtgaac tccctggggg agaacctgaa gaccctcagg      360

ctgaggctac ggcgctgtca tcgatttctt ccctgtgaaa acaagagcaa ggccgtggag      420

caggtgaaga atgcctttaa taagctccaa gagaaaggca tctacaaagc catgagtgag      480

tttgacatct tcatcaacta catagaagcc tacatgacaa tgaagatacg aaactga         537


<210>  69
<211>  483
<212>  DNA
<213>  Homo sapiens

<400>  69
agcccaggcc agggcaccca gtctgagaac agctgcaccc acttcccagg caacctgcct       60

aacatgcttc gagatctccg agatgccttc agcagagtga agactttctt tcaaatgaag      120

gatcagctgg acaacttgtt gttaaaggag tccttgctgg aggactttaa gggttacctg      180

ggttgccaag ccttgtctga gatgatccag ttttacctgg aggaggtgat gccccaagct      240

gagaaccaag acccagacat caaggcgcat gtgaactccc tgggggagaa cctgaagacc      300

ctcaggctga ggctacggcg ctgtcatcga tttcttccct gtgaaaacaa gagcaaggcc      360

gtggagcagg tgaagaatgc ctttaataag ctccaagaga aaggcatcta caaagccatg      420

agtgagtttg acatcttcat caactacata gaagcctaca tgacaatgaa gatacgaaac      480

tga                                                                    483


<210>  70
<211>  540
<212>  DNA
<213>  Homo sapiens

<400>  70
atggccgccc tgcagaaatc tgtgagctct ttccttatgg ggaccctggc caccagctgc       60

ctccttctct tggccctctt ggtacaggga ggagcagctg cgcccatcag ctcccactgc      120

aggcttgaca agtccaactt ccagcagccc tatatcacca accgcacctt catgctggct      180

aaggaggcta gcttggctga taacaacaca gacgttcgtc tcattgggga gaaactgttc      240

cacggagtca gtatgagtga gcgctgctat ctgatgaagc aggtgctgaa cttcaccctt      300

gaagaagtgc tgttccctca atctgatagg ttccagcctt atatgcagga ggtggtgccc      360

ttcctggcca ggctcagcaa caggctaagc acatgtcata ttgaaggtga tgacctgcat      420

atccagagga atgtgcaaaa gctgaaggac acagtgaaaa agcttggaga gagtggagag      480

atcaaagcaa ttggagaact ggatttgctg tttatgtctc tgagaaatgc ctgcatttga      540


<210>  71
<211>  441
<212>  DNA
<213>  Homo sapiens

<400>  71
gcgcccatca gctcccactg caggcttgac aagtccaact tccagcagcc ctatatcacc       60

aaccgcacct tcatgctggc taaggaggct agcttggctg ataacaacac agacgttcgt      120

ctcattgggg agaaactgtt ccacggagtc agtatgagtg agcgctgcta tctgatgaag      180

caggtgctga acttcaccct tgaagaagtg ctgttccctc aatctgatag gttccagcct      240

tatatgcagg aggtggtgcc cttcctggcc aggctcagca acaggctaag cacatgtcat      300

attgaaggtg atgacctgca tatccagagg aatgtgcaaa agctgaagga cacagtgaaa      360

aagcttggag agagtggaga gatcaaagca attggagaac tggatttgct gtttatgtct      420

ctgagaaatg cctgcatttg a                                                441


<210>  72
<211>  501
<212>  DNA
<213>  Homo sapiens

<400>  72
atgaaatata caagttatat cttggctttt cagctctgca tcgttttggg ttctcttggc       60

tgttactgcc aggacccata tgtaaaagaa gcagaaaacc ttaagaaata ttttaatgca      120

ggtcattcag atgtagcgga taatggaact cttttcttag gcattttgaa gaattggaaa      180

gaggagagtg acagaaaaat aatgcagagc caaattgtct ccttttactt caaacttttt      240

aaaaacttta aagatgacca gagcatccaa aagagtgtgg agaccatcaa ggaagacatg      300

aatgtcaagt ttttcaatag caacaaaaag aaacgagatg acttcgaaaa gctgactaat      360

tattcggtaa ctgacttgaa tgtccaacgc aaagcaatac atgaactcat ccaagtgatg      420

gctgaactgt cgccagcagc taaaacaggg aagcgaaaaa ggagtcagat gctgtttcga      480

ggtcgaagag catcccagta a                                                501


<210>  73
<211>  432
<212>  DNA
<213>  Homo sapiens

<400>  73
caggacccat atgtaaaaga agcagaaaac cttaagaaat attttaatgc aggtcattca       60

gatgtagcgg ataatggaac tcttttctta ggcattttga agaattggaa agaggagagt      120

gacagaaaaa taatgcagag ccaaattgtc tccttttact tcaaactttt taaaaacttt      180

aaagatgacc agagcatcca aaagagtgtg gagaccatca aggaagacat gaatgtcaag      240

tttttcaata gcaacaaaaa gaaacgagat gacttcgaaa agctgactaa ttattcggta      300

actgacttga atgtccaacg caaagcaata catgaactca tccaagtgat ggctgaactg      360

tcgccagcag ctaaaacagg gaagcgaaaa aggagtcaga tgctgtttcg aggtcgaaga      420

gcatcccagt aa                                                          432


<210>  74
<211>  435
<212>  DNA
<213>  Homo sapiens

<400>  74
atgtggctgc agagcctgct gctcttgggc actgtggcct gcagcatctc tgcacccgcc       60

cgctcgccca gccccagcac gcagccctgg gagcatgtga atgccatcca ggaggcccgg      120

cgtctcctga acctgagtag agacactgct gctgagatga atgaaacagt agaagtcatc      180

tcagaaatgt ttgacctcca ggagccgacc tgcctacaga cccgcctgga gctgtacaag      240

cagggcctgc ggggcagcct caccaagctc aagggcccct tgaccatgat ggccagccac      300

tacaagcagc actgccctcc aaccccggaa acttcctgtg caacccagat tatcaccttt      360

gaaagtttca aagagaacct gaaggacttt ctgcttgtca tcccctttga ctgctgggag      420

ccagtccagg agtga                                                       435


<210>  75
<211>  384
<212>  DNA
<213>  Homo sapiens

<400>  75
gcacccgccc gctcgcccag ccccagcacg cagccctggg agcatgtgaa tgccatccag       60

gaggcccggc gtctcctgaa cctgagtaga gacactgctg ctgagatgaa tgaaacagta      120

gaagtcatct cagaaatgtt tgacctccag gagccgacct gcctacagac ccgcctggag      180

ctgtacaagc agggcctgcg gggcagcctc accaagctca agggcccctt gaccatgatg      240

gccagccact acaagcagca ctgccctcca accccggaaa cttcctgtgc aacccagatt      300

atcacctttg aaagtttcaa agagaacctg aaggactttc tgcttgtcat cccctttgac      360

tgctgggagc cagtccagga gtga                                             384


<210>  76
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  76
atgaagcttc tcacgggcct ggttttctgc tccttggtcc tgggtgtcag cagccgaagc       60

ttcttttcgt tccttggcga ggcttttgat ggggctcggg acatgtggag agcctactct      120

gacatgagag aagccaatta catcggctca gacaaatact tccatgctcg ggggaactat      180

gatgctgcca aaaggggacc tgggggtgcc tgggctgcag aagtgatcac cgatgccaga      240

gagaatatcc agagattctt tggccatggt gcggaggact cgctggctga tcaggctgcc      300

aatgaatggg gcaggagtgg caaagacccc aatcacttcc gacctgctgg cctgcctgag      360

aaatactga                                                              369


<210>  77
<211>  315
<212>  DNA
<213>  Homo sapiens

<400>  77
cgaagcttct tttcgttcct tggcgaggct tttgatgggg ctcgggacat gtggagagcc       60

tactctgaca tgagagaagc caattacatc ggctcagaca aatacttcca tgctcggggg      120

aactatgatg ctgccaaaag gggacctggg ggtgcctggg ctgcagaagt gatcaccgat      180

gccagagaga atatccagag attctttggc catggtgcgg aggactcgct ggctgatcag      240

gctgccaatg aatggggcag gagtggcaaa gaccccaatc acttccgacc tgctggcctg      300

cctgagaaat actga                                                       315


<210>  78
<211>  675
<212>  DNA
<213>  Homo sapiens

<400>  78
atggagaagc tgttgtgttt cttggtcttg accagcctct ctcatgcttt tggccagaca       60

gacatgtcga ggaaggcttt tgtgtttccc aaagagtcgg atacttccta tgtatccctc      120

aaagcaccgt taacgaagcc tctcaaagcc ttcactgtgt gcctccactt ctacacggaa      180

ctgtcctcga cccgtgggta cagtattttc tcgtatgcca ccaagagaca agacaatgag      240

attctcatat tttggtctaa ggatatagga tacagtttta cagtgggtgg gtctgaaata      300

ttattcgagg ttcctgaagt cacagtagct ccagtacaca tttgtacaag ctgggagtcc      360

gcctcaggga tcgtggagtt ctgggtagat gggaagccca gggtgaggaa gagtctgaag      420

aagggataca ctgtgggggc agaagcaagc atcatcttgg ggcaggagca ggattccttc      480

ggtgggaact ttgaaggaag ccagtccctg gtgggagaca ttggaaatgt gaacatgtgg      540

gactttgtgc tgtcaccaga tgagattaac accatctatc ttggcgggcc cttcagtcct      600

aatgtcctga actggcgggc actgaagtat gaagtgcaag gcgaagtgtt caccaaaccc      660

cagctgtggc cctga                                                       675


<210>  79
<211>  621
<212>  DNA
<213>  Homo sapiens

<400>  79
cagacagaca tgtcgaggaa ggcttttgtg tttcccaaag agtcggatac ttcctatgta       60

tccctcaaag caccgttaac gaagcctctc aaagccttca ctgtgtgcct ccacttctac      120

acggaactgt cctcgacccg tgggtacagt attttctcgt atgccaccaa gagacaagac      180

aatgagattc tcatattttg gtctaaggat ataggataca gttttacagt gggtgggtct      240

gaaatattat tcgaggttcc tgaagtcaca gtagctccag tacacatttg tacaagctgg      300

gagtccgcct cagggatcgt ggagttctgg gtagatggga agcccagggt gaggaagagt      360

ctgaagaagg gatacactgt gggggcagaa gcaagcatca tcttggggca ggagcaggat      420

tccttcggtg ggaactttga aggaagccag tccctggtgg gagacattgg aaatgtgaac      480

atgtgggact ttgtgctgtc accagatgag attaacacca tctatcttgg cgggcccttc      540

agtcctaatg tcctgaactg gcgggcactg aagtatgaag tgcaaggcga agtgttcacc      600

aaaccccagc tgtggccctg a                                                621


<210>  80
<211>  678
<212>  DNA
<213>  Homo sapiens

<400>  80
atggaccaac aagcaatata tgctgagtta aacttaccca cagactcagg cccagaaagt       60

tcttcacctt catctcttcc tcgggatgtc tgtcagggtt caccttggca tcaatttgcc      120

ctgaaactta gctgtgctgg gattattctc cttgtcttgg ttgttactgg gttgagtgtt      180

tcagtgacat ccttaataca gaaatcatca atagaaaaat gcagtgtgga cattcaacag      240

agcaggaata aaacaacaga gagaccgggt ctcttaaact gcccaatata ttggcagcaa      300

ctccgagaga aatgcttgtt attttctcac actgtcaacc cttggaataa cagtctagct      360

gattgttcca ccaaagaatc cagcctgctg cttattcgag ataaggatga attgatacac      420

acacagaacc tgatacgtga caaagcaatt ctgttttgga ttggattaaa tttttcatta      480

tcagaaaaga actggaagtg gataaacggc tcttttttaa attctaatga cttagaaatt      540

agaggtgatg ctaaagaaaa cagctgtatt tccatctcac agacatctgt gtattctgag      600

tactgtagta cagaaatcag atggatctgc caaaaagaac taacacctgt gagaaataaa      660

gtgtatcctg actcttga                                                    678


<210>  81
<211>  2577
<212>  DNA
<213>  Homo sapiens

<400>  81
atgctgcaaa ctaaggatct catctggact ttgtttttcc tgggaactgc agtttctctg       60

caggtggata ttgttcccag ccagggggag atcagcgttg gagagtccaa attcttctta      120

tgccaagtgg caggagatgc caaagataaa gacatctcct ggttctcccc caatggagaa      180

aagctcaccc caaaccagca gcggatctca gtggtgtgga atgatgattc ctcctccacc      240

ctcaccatct ataacgccaa catcgacgac gccggcattt acaagtgtgt ggttacaggc      300

gaggatggca gtgagtcaga ggccaccgtc aacgtgaaga tctttcagaa gctcatgttc      360

aagaatgcgc caaccccaca ggagttccgg gagggggaag atgccgtgat tgtgtgtgat      420

gtggtcagct ccctcccacc aaccatcatc tggaaacaca aaggccgaga tgtcatcctg      480

aaaaaagatg tccgattcat agtcctgtcc aacaactacc tgcagatccg gggcatcaag      540

aaaacagatg agggcactta tcgctgtgag ggcagaatcc tggcacgggg ggagatcaac      600

ttcaaggaca ttcaggtcat tgtgaatgtg ccacctacca tccaggccag gcagaatatt      660

gtgaatgcca ccgccaacct cggccagtcc gtcaccctgg tgtgcgatgc cgaaggcttc      720

ccagagccca ccatgagctg gacaaaggat ggggaacaga tagagcaaga ggaagacgat      780

gagaagtaca tcttcagcga cgatagttcc cagctgacca tcaaaaaggt ggataagaac      840

gacgaggctg agtacatctg cattgctgag aacaaggctg gcgagcagga tgcgaccatc      900

cacctcaaag tctttgcaaa acccaaaatc acatatgtag agaaccagac tgccatggaa      960

ttagaggagc aggtcactct tacctgtgaa gcctccggag accccattcc ctccatcacc     1020

tggaggactt ctacccggaa catcagcagc gaagaaaagg cttcgtggac tcgaccagag     1080

aagcaagaga ctctggatgg gcacatggtg gtgcgtagcc atgcccgtgt gtcgtcgctg     1140

accctgaaga gcatccagta cactgatgcc ggagagtaca tctgcaccgc cagcaacacc     1200

atcggccagg actcccagtc catgtacctt gaagtgcaat atgccccaaa gctacagggc     1260

cctgtggctg tgtacacttg ggaggggaac caggtgaaca tcacctgcga ggtatttgcc     1320

tatcccagtg ccacgatctc atggtttcgg gatggccagc tgctgccaag ctccaattac     1380

agcaatatca agatctacaa caccccctct gccagctatc tggaggtgac cccagactct     1440

gagaatgatt ttgggaacta caactgtact gcagtgaacc gcattgggca ggagtccttg     1500

gaattcatcc ttgttcaagc agacaccccc tcttcaccat ccatcgacca ggtggagcca     1560

tactccagca cagcccaggt gcagtttgat gaaccagagg ccacaggtgg ggtgcccatc     1620

ctcaaataca aagctgagtg gagagcagtt ggtgaagaag tatggcattc caagtggtat     1680

gatgccaagg aagccagcat ggagggcatc gtcaccatcg tgggcctgaa gcccgaaaca     1740

acgtacgccg taaggctggc ggcgctcaat ggcaaagggc tgggtgagat cagcgcggcc     1800

tccgagttca agacgcagcc agtccaaggg gaacccagtg cacctaagct cgaagggcag     1860

atgggagagg atggaaactc tattaaagtg aacctgatca agcaggatga cggcggctcc     1920

cccatcagac actatctggt caggtaccga gcgctctcct ccgagtggaa accagagatc     1980

aggctcccgt ctggcagtga ccacgtcatg ctgaagtccc tggactggaa tgctgagtat     2040

gaggtctacg tggtggctga gaaccagcaa ggaaaatcca aggcggctca ttttgtgttc     2100

aggacctcgg cccagcccac agccatccca gccaacggca gccccacctc aggcctgagc     2160

accggggcca tcgtgggcat cctcatcgtc atcttcgtcc tgctcctggt ggttgtggac     2220

atcacctgct acttcctgaa caagtgtggc ctgttcatgt gcattgcggt caacctgtgt     2280

ggaaaagccg ggcccggggc caagggcaag gacatggagg agggcaaggc cgccttctcg     2340

aaagatgagt ccaaggagcc catcgtggag gttcgaacgg aggaggagag gaccccaaac     2400

catgatggag ggaaacacac agagcccaac gagaccacgc cactgacgga gcccgagaag     2460

ggccccgtag aagcaaagcc agagtgccag gagacagaaa cgaagccagc gccagccgaa     2520

gtcaagacgg tccccaatga cgccacacag acaaaggaga acgagagcaa agcatga        2577


<210>  82
<211>  2520
<212>  DNA
<213>  Homo sapiens

<400>  82
ctgcaggtgg atattgttcc cagccagggg gagatcagcg ttggagagtc caaattcttc       60

ttatgccaag tggcaggaga tgccaaagat aaagacatct cctggttctc ccccaatgga      120

gaaaagctca ccccaaacca gcagcggatc tcagtggtgt ggaatgatga ttcctcctcc      180

accctcacca tctataacgc caacatcgac gacgccggca tttacaagtg tgtggttaca      240

ggcgaggatg gcagtgagtc agaggccacc gtcaacgtga agatctttca gaagctcatg      300

ttcaagaatg cgccaacccc acaggagttc cgggaggggg aagatgccgt gattgtgtgt      360

gatgtggtca gctccctccc accaaccatc atctggaaac acaaaggccg agatgtcatc      420

ctgaaaaaag atgtccgatt catagtcctg tccaacaact acctgcagat ccggggcatc      480

aagaaaacag atgagggcac ttatcgctgt gagggcagaa tcctggcacg gggggagatc      540

aacttcaagg acattcaggt cattgtgaat gtgccaccta ccatccaggc caggcagaat      600

attgtgaatg ccaccgccaa cctcggccag tccgtcaccc tggtgtgcga tgccgaaggc      660

ttcccagagc ccaccatgag ctggacaaag gatggggaac agatagagca agaggaagac      720

gatgagaagt acatcttcag cgacgatagt tcccagctga ccatcaaaaa ggtggataag      780

aacgacgagg ctgagtacat ctgcattgct gagaacaagg ctggcgagca ggatgcgacc      840

atccacctca aagtctttgc aaaacccaaa atcacatatg tagagaacca gactgccatg      900

gaattagagg agcaggtcac tcttacctgt gaagcctccg gagaccccat tccctccatc      960

acctggagga cttctacccg gaacatcagc agcgaagaaa aggcttcgtg gactcgacca     1020

gagaagcaag agactctgga tgggcacatg gtggtgcgta gccatgcccg tgtgtcgtcg     1080

ctgaccctga agagcatcca gtacactgat gccggagagt acatctgcac cgccagcaac     1140

accatcggcc aggactccca gtccatgtac cttgaagtgc aatatgcccc aaagctacag     1200

ggccctgtgg ctgtgtacac ttgggagggg aaccaggtga acatcacctg cgaggtattt     1260

gcctatccca gtgccacgat ctcatggttt cgggatggcc agctgctgcc aagctccaat     1320

tacagcaata tcaagatcta caacaccccc tctgccagct atctggaggt gaccccagac     1380

tctgagaatg attttgggaa ctacaactgt actgcagtga accgcattgg gcaggagtcc     1440

ttggaattca tccttgttca agcagacacc ccctcttcac catccatcga ccaggtggag     1500

ccatactcca gcacagccca ggtgcagttt gatgaaccag aggccacagg tggggtgccc     1560

atcctcaaat acaaagctga gtggagagca gttggtgaag aagtatggca ttccaagtgg     1620

tatgatgcca aggaagccag catggagggc atcgtcacca tcgtgggcct gaagcccgaa     1680

acaacgtacg ccgtaaggct ggcggcgctc aatggcaaag ggctgggtga gatcagcgcg     1740

gcctccgagt tcaagacgca gccagtccaa ggggaaccca gtgcacctaa gctcgaaggg     1800

cagatgggag aggatggaaa ctctattaaa gtgaacctga tcaagcagga tgacggcggc     1860

tcccccatca gacactatct ggtcaggtac cgagcgctct cctccgagtg gaaaccagag     1920

atcaggctcc cgtctggcag tgaccacgtc atgctgaagt ccctggactg gaatgctgag     1980

tatgaggtct acgtggtggc tgagaaccag caaggaaaat ccaaggcggc tcattttgtg     2040

ttcaggacct cggcccagcc cacagccatc ccagccaacg gcagccccac ctcaggcctg     2100

agcaccgggg ccatcgtggg catcctcatc gtcatcttcg tcctgctcct ggtggttgtg     2160

gacatcacct gctacttcct gaacaagtgt ggcctgttca tgtgcattgc ggtcaacctg     2220

tgtggaaaag ccgggcccgg ggccaagggc aaggacatgg aggagggcaa ggccgccttc     2280

tcgaaagatg agtccaagga gcccatcgtg gaggttcgaa cggaggagga gaggacccca     2340

aaccatgatg gagggaaaca cacagagccc aacgagacca cgccactgac ggagcccgag     2400

aagggccccg tagaagcaaa gccagagtgc caggagacag aaacgaagcc agcgccagcc     2460

gaagtcaaga cggtccccaa tgacgccaca cagacaaagg agaacgagag caaagcatga     2520


