                         SEQUENCE LISTING

<110>  Vir Biotechnology, Inc.
       Humabs BioMed SA
 
<120>  BROADLY NEUTRALIZING ANTIBODIES 
       AGAINST INFLUENZA NEURAMINIDASE

<130>  930585.414WO

<150>  US 63/117,448
<151>  2020-11-23

<150>  US 63/123,424
<151>  2020-12-09

<150>  US 63/197,160
<151>  2021-06-04

<150>  US 63/261,463
<151>  2021-09-21

<160>  236   

<170>  PatentIn version 3.5

<210>  1
<211>  385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI1 VH (wt-nt)

<400>  1
caagttcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaggatc       60

tcctgcaagg cctctggtga caccttcaac aactatgttc tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggggga atcatcccta tctctggtat cccacattac      180

gcacagaagt tccagggcag agtcgcaatt atcgcggacg aatccgcgag cacagtctac      240

atggagttga gcagcctacg atctgaggac tcggccgtat attactgtgc gagagcggtt      300

tccgattatt ttaatcgaga cctcggctgg gatgattact actttccttt gtggggccag      360

ggcaccctgg tcaccgtctc ctcag                                            385


<210>  2
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI1 VH (aa)

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Asp Thr Phe Asn Asn Tyr 
            20                  25                  30          


Val Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Ser Gly Ile Pro His Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Ile Ile Ala Asp Glu Ser Ala Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Asp Asp 
            100                 105                 110         


Tyr Tyr Phe Pro Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI1 CDRH1 (aa)

<400>  3

Gly Asp Thr Phe Asn Asn Tyr Val 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI1 CDRH2 (aa)

<400>  4

Ile Ile Pro Ile Ser Gly Ile Pro 
1               5               


<210>  5
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI1 CDRH3 (aa)

<400>  5

Ala Arg Ala Val Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Asp Asp 
1               5                   10                  15      


Tyr Tyr Phe Pro Leu 
            20      


<210>  6
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI1 VH (co-nt)

<400>  6
caggtgcagc tggtgcagtc tggagctgag gtgaagaggc caggatccag cgtgcggatc       60

agctgcaagg cttctggcga caccttcaac aattacgtgc tgtcctgggt gaggcaggct      120

ccaggacagg gactggagtg gatgggcggc atcatcccca tcagcggcat ccctcactac      180

gcccagaagt ttcagggcag ggtggccatc atcgctgacg agtccgctag cacagtgtat      240

atggagctgt cttccctgag atctgaggat tccgccgtgt actattgtgc cagagccgtg      300

tccgactatt tcaaccgcga tctgggctgg gacgattact attttccact gtggggacag      360

ggcaccctgg tgacagtgag ctct                                             384


<210>  7
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI1 Vk (wt-nt)

<400>  7
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctcttctgca gggccagtcg gagtgttagt gacaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctttggt gcctccacca gggccactgg tgtcccagcc      180

aggttcggtg gcagtgggtc tgggacacag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcat tataatacct ggcctccgtg gaccttcggc      300

caagggacca aggtggaaat caaac                                            325


<210>  8
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI1 VK (aa)

<400>  8

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Arg Ser Val Ser Asp Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Gly Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asn Thr Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI1 CDRL1(aa)

<400>  9

Arg Ser Val Ser Asp Asn 
1               5       


<210>  10
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI1 CDRL2(aa)

<400>  10

Gly Ala Ser 
1           


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI1 CDRL3(aa)

<400>  11

Gln His Tyr Asn Thr Trp Pro Pro Trp Thr 
1               5                   10  


<210>  12
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI1 Vk (co-nt)

<400>  12
gagatcgtga tgacccagtc tcctgccaca ctgtccgtgt ccccaggcga gagggccaca       60

ctgttctgca gggctagcag gtccgtgtcc gacaacctgg cctggtacca gcagaagcca      120

ggccaggctc ccagactgct gatctttgga gcttccacca gagctacagg cgtgccagct      180

aggttcggag gaagcggatc tggcacccag tttaccctga caatctccag cctgcagagc      240

gaggatttcg ccgtgtacta ttgtcagcac tataatacct ggcccccttg gacatttggc      300

cagggcacca aggtggagat caag                                             324


<210>  13
<211>  385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI2 VH (wt-nt)

<400>  13
caggttcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgagggtc       60

tcctgcaagg cttctggagc caccttcaat aaccatgttc tcacctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctg tctctggaaa aacaacctac      180

gcacagaagt tccagggcag agtcgcgata agcacggacg aatccgcgag cacagcctat      240

atggagttga gcagcctgag atctgaggac tcggccatat attactgtgc gagagcggtt      300

tccgattact ttaatcgaga cctcggctgg gaagattatt actttccgat ctggggccag      360

ggcaccctgg tcaccgtctc ttcag                                            385


<210>  14
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI2 VH (aa)

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Ala Thr Phe Asn Asn His 
            20                  25                  30          


Val Leu Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Val Ser Gly Lys Thr Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Ile Ser Thr Asp Glu Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asp 
            100                 105                 110         


Tyr Tyr Phe Pro Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI2 CDRH1 (aa)

<400>  15

Gly Ala Thr Phe Asn Asn His Val 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI2 CDRH2 (aa)

<400>  16

Ile Ile Pro Val Ser Gly Lys Thr 
1               5               


<210>  17
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI2 CDRH3 (aa)

<400>  17

Ala Arg Ala Val Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asp 
1               5                   10                  15      


Tyr Tyr Phe Pro Ile 
            20      


<210>  18
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI2 VH (co-nt)

<400>  18
caggtgcagc tggtgcagtc tggagctgag gtgaagaggc caggatccag cgtgcgggtg       60

agctgcaagg cttctggagc taccttcaac aatcacgtgc tgacatgggt gaggcaggct      120

ccaggacagg gactggagtg gatgggcggc atcatccccg tgtccggcaa gaccacatac      180

gcccagaagt ttcagggcag ggtggctatc agcaccgatg agtccgccag cacagcttat      240

atggagctgt cttccctgag atctgaggac tccgccatct actattgtgc cagagccgtg      300

tccgactact tcaaccgcga tctgggctgg gaggactact attttcccat ctggggccag      360

ggcaccctgg tgacagtgag ctct                                             384


<210>  19
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI2 Vk (wt-nt)

<400>  19
gacgtagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagt agcaacttgg cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tgtcccagcc      180

aggttcagtg gcagtgggtc tgggacacag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcac tataataact ggcctccgtg gacgttcggc      300

caagggacca agttggaaat caaac                                            325


<210>  20
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI2 VK (aa)

<400>  20

Asp Val Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI2 CDRL1(aa)

<400>  21

Gln Ser Val Ser Ser Asn 
1               5       


<210>  22
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI2 CDRL2(aa)

<400>  22

Gly Ala Ser 
1           


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI2 CDRL3(aa)

<400>  23

Gln His Tyr Asn Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210>  24
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI2 Vk (co-nt)

<400>  24
gacgtggtca tgacccagtc tcctgccaca ctgagcgtgt ctccaggaga gagggccacc       60

ctgtcctgca gggcttccca gagcgtgtcc agcaacctgg cctggtacca gcagaagcca      120

ggccaggctc ccaggctgct gatctatgga gctagcacca gagctacagg cgtgccagct      180

cgcttctctg gatccggaag cggcacacag tttaccctga caatctcttc cctgcagtct      240

gaggatttcg ccgtgtacta ttgtcagcac tacaacaatt ggcccccttg gacctttggc      300

cagggcacaa agctggagat caag                                             324


<210>  25
<211>  385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI3 VH (wt-nt)

<400>  25
caggttcagc tggtgcagtc gggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagc caccttcagc aacaatgtta tagcctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatggggggg atccacccta tctctgctac agcaacctac      180

gcacagaagt tccagggcag agtcgcgatt gccgcggacg aattaacgag cacagcctac      240

atggagttga atggcctgag atctgaggac tcggccgtgt attactgtgc gagagcgggg      300

tccgattact ttaatagaga cctcggctgg gaaaattact actttgactc ctggggccag      360

ggaaccctgg tcaccgtctc gtcag                                            385


<210>  26
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI3 VH (aa)

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ala Thr Phe Ser Asn Asn 
            20                  25                  30          


Val Ile Ala Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile His Pro Ile Ser Ala Thr Ala Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Ile Ala Ala Asp Glu Leu Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Gly Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asn 
            100                 105                 110         


Tyr Tyr Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI3 CDRH1 (aa)

<400>  27

Gly Ala Thr Phe Ser Asn Asn Val 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI3 CDRH2 (aa)

<400>  28

Ile His Pro Ile Ser Ala Thr Ala 
1               5               


<210>  29
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI3 CDRH3 (aa)

<400>  29

Ala Arg Ala Gly Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asn 
1               5                   10                  15      


Tyr Tyr Phe Asp Ser 
            20      


<210>  30
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI3 VH (co-nt)

<400>  30
caggtgcagc tggtgcagtc cggagctgag gtgaagaggc caggatccag cgtgaaggtg       60

tcctgcaagg ccagcggcgc taccttcagc aacaatgtga tcgcttgggt gagacaggct      120

ccaggacagg gactggagtg gatgggagga atccacccta tcagcgccac cgctacatac      180

gcccagaagt ttcagggcag agtggctatc gccgctgacg agctgacctc tacagcctat      240

atggagctga acggcctgcg cagcgaggat tccgccgtgt actattgtgc cagggctggc      300

tctgactact tcaaccggga tctgggctgg gagaattact attttgactc ctggggccag      360

ggcaccctgg tgacagtgtc ttcc                                             384


<210>  31
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI3 Vk (wt-nt)

<400>  31
gaaatattga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca ggatgttagc ggcaacttag cctggtacca gcagagacct      120

ggccaggctc ccaggctcct tatctatggt gcatccacga gggccactgg tgtcccagcc      180

aggttcactg gcgctgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaggattttg cactttatta ctgtcagcac tataataact ggcctccgtg gaccttcggc      300

caagggacca aggtggaaat caaac                                            325


<210>  32
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI3 Vk (aa)

<400>  32

Glu Ile Leu Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Val Ser Gly Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Thr Gly 
    50                  55                  60                  


Ala Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Leu Tyr Tyr Cys Gln His Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI3 CDRL1(aa)

<400>  33

Gln Asp Val Ser Gly Asn 
1               5       


<210>  34
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI3 CDRL2(aa)

<400>  34

Gly Ala Ser 
1           


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI3 CDRL3(aa)

<400>  35

Gln His Tyr Asn Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210>  36
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI3 Vk (co-nt)

<400>  36
gagatcctga tgacccagtc ccctgccaca ctgtccgtgt ccccaggaga gagggccacc       60

ctgagctgca gggcttctca ggacgtgtcc ggcaacctgg cctggtacca gcagagacca      120

ggacaggctc caaggctgct gatctatgga gcttccacca gggctacagg cgtgccagct      180

agattcaccg gcgctggaag cggcacagag tttaccctga caatctccag cctgcagtct      240

gaggatttcg ctctgtacta ttgtcagcac tacaacaatt ggcccccttg gacctttggc      300

cagggcacaa aggtggagat caag                                             324


<210>  37
<211>  385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI4 VH (wt-nt)

<400>  37
caggagcagc tggtacagtc tggggctgag gtgaagaagc cggggtcctc ggtgagggtc       60

tcctgcaagg cctctggaga caccttcagc agatatacta tcagctgggt tcgacaggcc      120

cccggacaag gacttgagtg gatgggaggg atcatcgctc tctctcgaag agcgacatac      180

gcacagaagt tccagggcag agttaccatt accgcggacg aatccgcgac cacagcctac      240

atacaactga gcggcctgac atctgacgac acggccgtat attactgtgc gagagcacac      300

tccgattact ttaatagaga cctcggctgg gaagattact actttgacta ctggggccag      360

ggaaccctgg tcaccgtctc ctcag                                            385


<210>  38
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI4 VH (aa)

<400>  38

Gln Glu Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Arg Tyr 
            20                  25                  30          


Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Ala Leu Ser Arg Arg Ala Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Ala Thr Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala His Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asp 
            100                 105                 110         


Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI4 CDRH1 (aa)

<400>  39

Gly Asp Thr Phe Ser Arg Tyr Thr 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI4 CDRH2 (aa)

<400>  40

Ile Ile Ala Leu Ser Arg Arg Ala 
1               5               


<210>  41
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI4 CDRH3 (aa)

<400>  41

Ala Arg Ala His Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asp 
1               5                   10                  15      


Tyr Tyr Phe Asp Tyr 
            20      


<210>  42
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI4 VH (co-nt)

<400>  42
caggagcagc tggtgcagtc cggagctgag gtgaagaagc caggatccag cgtgagagtg       60

agctgcaagg cttctggcga caccttctct agatacacaa tctcctgggt gcgccaggct      120

cctggacagg gactggagtg gatgggagga atcatcgctc tgagcaggcg ggccacctac      180

gctcagaagt ttcagggccg cgtgaccatc acagccgatg agtctgccac cacagcttat      240

atccagctgt ccggcctgac cagcgacgat acagccgtgt actattgtgc cagggctcac      300

agcgactact tcaaccggga tctgggctgg gaggactact attttgatta ttggggccag      360

ggcaccctgg tgacagtgtc ttcc                                             384


<210>  43
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI4 Vk (wt-nt)

<400>  43
gaagtagtgc tgacgcagtc tccagccacc ctgtctgtgt ctctagggga aagagccatc       60

ctctcctgca gggccagtca gagtgttagc accaacttag cctggtacca gcagagacct      120

ggccaggctc ccaggctcct catctctggt gcatccacca gggccacggg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcacgctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctccgtg gacgttcggc      300

caagggacca aggtggaaat cagac                                            325


<210>  44
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI4 VK (aa)

<400>  44

Glu Val Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Ile Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg 
            100                 105             


<210>  45
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI4 CDRL1 (aa)

<400>  45

Gln Ser Val Ser Thr Asn 
1               5       


<210>  46
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI4 CDRL2 (aa)

<400>  46

Gly Ala Ser 
1           


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI4 CDRL3 (aa)

<400>  47

Gln Gln Tyr Asn Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210>  48
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI4 Vk (co-nt)

<400>  48
gaggtggtgc tgacccagtc ccctgccaca ctgtccgtgt ccctgggaga gagggctatc       60

ctgagctgca gggctagcca gtccgtgtcc accaacctgg cctggtacca gcagagacca      120

ggacaggctc caaggctgct gatcagcgga gcttctacca gggctacagg catcccagcc      180

agattcagcg gctctggctc cggcacagag tttaccctga caatctccag cctgcagtct      240

gaggacttcg ccgtgtacta ttgtcagcag tataacaatt ggcccccttg gacctttggc      300

cagggcacaa aggtggagat cagg                                             324


<210>  49
<211>  385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI5 VH (wt-nt)

<400>  49
caggtgcagc tgatacaatc tgaggctgag gtgaagaagc ctgggtcctc ggtgagggtc       60

tcctgcaagg cttctggaga caccttcagc aaatatacta tcggctgggt gcgacaggcc      120

cccggacaag ggcttgagtg gatgggaggg atcatccctc tctctcgaac agcgacctac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgac cacagtttac      240

atgcaactga gcggcctgag atctgacgac acggccgcat attactgtgc gagagcacgc      300

tcggattact ttaatagaga cctcggctgg gacgattact actttgatta ctggggccag      360

ggaaccctgg tcaccgtctc ctcag                                            385


<210>  50
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI5 VH (aa)

<400>  50

Gln Val Gln Leu Ile Gln Ser Glu Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Lys Tyr 
            20                  25                  30          


Thr Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Ser Arg Thr Ala Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Arg Ser Asp Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Arg Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Asp Asp 
            100                 105                 110         


Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI5 CDRH1 (aa)

<400>  51

Gly Asp Thr Phe Ser Lys Tyr Thr 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI5 CDRH2 (aa)

<400>  52

Ile Ile Pro Leu Ser Arg Thr Ala 
1               5               


<210>  53
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI5 CDRH3 (aa)

<400>  53

Ala Arg Ala Arg Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Asp Asp 
1               5                   10                  15      


Tyr Tyr Phe Asp Tyr 
            20      


<210>  54
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI5 VH (co-nt)

<400>  54
caggtgcagc tgatccagag cgaggccgag gtgaagaagc caggctccag cgtgagggtg       60

agctgcaagg cttctggcga cacattctct aagtacacca tcggatgggt gcggcaggct      120

ccaggacagg gcctggagtg gatgggcggc atcatccctc tgtctagaac agccacctac      180

gctcagaagt ttcagggccg cgtgacaatc accgctgacg agtccaccac aaccgtgtat      240

atgcagctgt ccggcctgag aagcgacgat acagccgctt actattgtgc cagggctcgg      300

tccgactact tcaaccgcga tctgggctgg gacgattact attttgatta ttggggccag      360

ggcacactgg tgaccgtgtc ttcc                                             384


<210>  55
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI5 Vk (wt-nt)

<400>  55
gaaatagtga tgacgcagtc tccagccaac ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gactgttagc accaacttag cctggtacca gcagaagcct      120

ggccaggctc ccaggctcct catctctggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcacgctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataatt ggcctccgtg gacgttcggc      300

caagggacca aggtggaaat cagac                                            325


<210>  56
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI5 VK (aa)

<400>  56

Glu Ile Val Met Thr Gln Ser Pro Ala Asn Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg 
            100                 105             


<210>  57
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI5 CDRL1(aa)

<400>  57

Gln Thr Val Ser Thr Asn 
1               5       


<210>  58
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI5 CDRL2(aa)

<400>  58

Gly Ala Ser 
1           


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI5 CDRL3(aa)

<400>  59

Gln Gln Tyr Asn Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210>  60
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI5 Vk (co-nt)

<400>  60
gagatcgtga tgacccagtc ccctgctaac ctgtccgtgt ccccaggaga gagggccaca       60

ctgtcctgcc gggctagcca gaccgtgtct acaaatctgg cctggtacca gcagaagcca      120

ggacaggctc caaggctgct gatcagcgga gcttctacca gagctacagg catcccagct      180

cgcttcagcg gatctggatc cggcaccgag tttaccctga caatctccag cctgcagagc      240

gaggacttcg ccgtgtacta ttgtcagcag tataacaatt ggcccccttg gacctttggc      300

cagggcacaa aggtggagat caga                                             324


<210>  61
<211>  385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI6 VH (wt-nt)

<400>  61
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctctggagg caccttcagt agtcaagtta tcagctgggt gcgagaggcc      120

ccaggacaag ggcttgagtg gatgggaggg atcattccta tcactggaat agcgaacaac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg gatccacggg cacagtctac      240

atggagttga gcagcctgag atctggggac acggccgtct attactgtgc gagagcgggt      300

tcggattatt ttaatagaga cctcggctgg gaaaattact actttgaata ttggggccag      360

ggaaccctgg tcaccgtctc ctcag                                            385


<210>  62
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI6 VH (aa)

<400>  62

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Gln 
            20                  25                  30          


Val Ile Ser Trp Val Arg Glu Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Thr Gly Ile Ala Asn Asn Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Gly Ser Thr Gly Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asn 
            100                 105                 110         


Tyr Tyr Phe Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI6 CDRH1 (aa)

<400>  63

Gly Gly Thr Phe Ser Ser Gln Val 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI6 CDRH2 (aa)

<400>  64

Ile Ile Pro Ile Thr Gly Ile Ala 
1               5               


<210>  65
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI6 CDRH3 (aa)

<400>  65

Ala Arg Ala Gly Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asn 
1               5                   10                  15      


Tyr Tyr Phe Glu Tyr 
            20      


<210>  66
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI6 VH (co-nt)

<400>  66
caggtgcagc tggtgcagag cggagctgag gtgaagaagc caggctccag cgtgaaggtg       60

tcttgcaagg cttccggcgg caccttctct tcccaggtca tctcttgggt gagggaggct      120

ccaggacagg gactggagtg gatgggcggc atcatcccta tcacaggcat cgccaacaat      180

gctcagaagt ttcagggcag agtgaccatc acagccgacg gcagcaccgg cacagtgtac      240

atggagctga gctctctgcg ctctggcgat accgccgtgt actattgtgc cagggctggc      300

tccgactact tcaaccggga tctgggctgg gagaattact attttgagta ttggggccag      360

ggcaccctgg tgacagtgtc cagc                                             384


<210>  67
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI6 Vk (wt-nt)

<400>  67
gaaatcgtga tgacacagtc tccagccacc ctgtctgtat ctccagggga aagagccatc       60

ctctcctgca gggccagtca gagtgttagc acccacttag cctggtacca gcagaaacct      120

ggccaggctc ccagactcct cgtttttgat gcatccacca gggccactgg tgtcccagcc      180

agattcggtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattctg ctgtttatta ctgtcaacac tataataact ggcctccgtg gacgttcggc      300

caagggacca acgtggaaat cagac                                            325


<210>  68
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI6 VK (aa)

<400>  68

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Ile Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr His 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Val 
        35                  40                  45              


Phe Asp Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Gly Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Ser Ala Val Tyr Tyr Cys Gln His Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Asn Val Glu Ile Arg 
            100                 105             


<210>  69
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI6 CDRL1(aa)

<400>  69

Gln Ser Val Ser Thr His 
1               5       


<210>  70
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI6 CDRL2(aa)

<400>  70

Asp Ala Ser 
1           


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI6 CDRL3(aa)

<400>  71

Gln His Tyr Asn Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210>  72
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI6 Vk (co-nt)

<400>  72
gagatcgtga tgacccagtc tcctgccaca ctgtccgtgt ccccaggaga gagggctatc       60

ctgtcctgca gggctagcca gtccgtgtcc acccacctgg cctggtacca gcagaagcca      120

ggccaggctc ccaggctgct ggtgttcgac gctagcacca gagctacagg cgtgccagct      180

aggttcggag gaagcggatc tggcacagag tttaccctga caatctccag cctgcagtcc      240

gaggattccg ccgtgtacta ttgtcagcat tataacaatt ggcccccttg gacctttggc      300

cagggcacaa acgtggagat caga                                             324


<210>  73
<211>  385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI7 VH (wt-nt)

<400>  73
caagtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaagtc       60

tcctgtaaga cttctggagg caccttcaat aggcaagtta tcagctgggt gcgacaggcc      120

ccaggacaag gacttgagtg gatgggaggg atcctccctc ttactggtag aggggacgag      180

gcagagaggt ttcagggcag agtcaccatt accgcggacg aatctgagag tacagtctac      240

atggacttga gcagcctgag atctggggac acggccgtct attactgtgc gagagcgcgt      300

tcggattact ttaatagaga cctcggctgg gaaaattact actttgaatc ttggggccag      360

ggaaccctgg tcaccgtctc ctcag                                            385


<210>  74
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI7 VH (aa)

<400>  74

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Asn Arg Gln 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Leu Pro Leu Thr Gly Arg Gly Asp Glu Ala Glu Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Glu Ser Thr Val Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Arg Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asn 
            100                 105                 110         


Tyr Tyr Phe Glu Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI7 CDRH1 (aa)

<400>  75

Gly Gly Thr Phe Asn Arg Gln Val 
1               5               


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI7 CDRH2 (aa)

<400>  76

Ile Leu Pro Leu Thr Gly Arg Gly 
1               5               


<210>  77
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI7 CDRH3 (aa)

<400>  77

Ala Arg Ala Arg Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asn 
1               5                   10                  15      


Tyr Tyr Phe Glu Ser 
            20      


<210>  78
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI7 VH (co-nt)

<400>  78
caggtgcagc tggtgcagtc cggagctgag gtgaagaagc caggctccag cgtgaaggtg       60

tcttgcaaga cctccggcgg cacattcaac aggcaggtca tcagctgggt gcggcaggct      120

ccaggacagg gactggagtg gatgggagga atcctgcctc tgaccggcag gggcgacgag      180

gccgagagat ttcagggccg cgtgaccatc acagctgatg agtccgagag caccgtgtac      240

atggacctgt cttccctgag aagcggcgat acagccgtgt actattgtgc cagggctcgg      300

tctgactatt tcaaccgcga tctgggctgg gagaattact attttgagtc ttggggccag      360

ggcaccctgg tgacagtgag ctct                                             384


<210>  79
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI7 Vk (wt-nt)

<400>  79
gaaatcgtga tgacgcagtc tccagccacc ctgtctgtat ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagt accgacttag tctggtacca gcagaaacct      120

ggccaggctc cccggctcct catttatgat gcatccacta gggccactgg tatcccagcc      180

aggttcggtg gcagggggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattctg ctgtttatta ctgtcagcac tattcttact ggcctccgtg gacattcggc      300

caagggacca aagtggaaat caatc                                            325


<210>  80
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI7 VK (aa)

<400>  80

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Asp 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Gly Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Ser Ala Val Tyr Tyr Cys Gln His Tyr Ser Tyr Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Asn 
            100                 105             


<210>  81
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI7 CDRL1(aa)

<400>  81

Gln Ser Val Ser Thr Asp 
1               5       


<210>  82
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI7 CDRL2(aa)

<400>  82

Asp Ala Ser 
1           


<210>  83
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI7 CDRL3(aa)

<400>  83

Gln His Tyr Ser Tyr Trp Pro Pro Trp Thr 
1               5                   10  


<210>  84
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI7 Vk (co-nt)

<400>  84
gagatcgtga tgacccagtc ccctgccaca ctgtccgtgt ccccaggaga gagagccacc       60

ctgagctgca gggctagcca gtccgtgtcc acagacctgg tgtggtacca gcagaagcca      120

ggacaggctc caaggctgct gatctatgat gcctctacca gagctacagg catcccagct      180

aggttcggag gaaggggatc cggcaccgag tttaccctga caatctccag cctgcagagc      240

gaggactccg ccgtgtacta ttgtcagcac tacagctatt ggcccccttg gaccttcggc      300

cagggcacaa aggtggagat caac                                             324


<210>  85
<211>  385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI9 VH (wt-nt)

<400>  85
caggtccacc tggtgcagtc tggggctgag gtgaaggagc ctgggtcctc ggtgacggtc       60

tcctgcaagg catctggagg cagcttcaac aaccaggcta ttagctgggt gcgacaggcc      120

ccaggacaag gccttgagtg gatgggaggg atcttcccta tctctggcac accgaccagc      180

gcacagaggt tccagggcag agtcacattt accgcggacg agtccacgac cacagtctac      240

atggatctga gcagcctgag atctgacgac acggccgtct actactgtgc gagagcgggt      300

tcggattact ttaatagaga cctcggctgg gaaaactact actttgcgtc ctggggccag      360

ggaaccctgg tcaccgtctc ctcag                                            385


<210>  86
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9 VH (aa)

<400>  86

Gln Val His Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Asn Asn Gln 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Phe Pro Ile Ser Gly Thr Pro Thr Ser Ala Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asn 
            100                 105                 110         


Tyr Tyr Phe Ala Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9 CDRH1 (aa)

<400>  87

Gly Gly Ser Phe Asn Asn Gln Ala 
1               5               


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9 CDRH2 (aa)

<400>  88

Ile Phe Pro Ile Ser Gly Thr Pro 
1               5               


<210>  89
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9 CDRH3 (aa)

<400>  89

Ala Arg Ala Gly Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asn 
1               5                   10                  15      


Tyr Tyr Phe Ala Ser 
            20      


<210>  90
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI9 VH (co-nt)

<400>  90
caggtgcacc tggtgcagag cggagctgag gtgaaggagc caggatccag cgtgacagtg       60

tcttgcaagg cttccggcgg cagcttcaac aatcaggcta tctcctgggt gaggcaggct      120

ccaggacagg gactggagtg gatgggcggc atctttccca tctctggcac acctacctcc      180

gcccagaggt tccagggaag ggtgaccttc accgctgacg agagcaccac aaccgtgtac      240

atggatctgt cttccctgag atctgacgat accgccgtgt actattgtgc cagagctggc      300

tccgactatt tcaaccgcga tctgggctgg gagaattact attttgcttc ctggggccag      360

ggcacactgg tgaccgtgag ctct                                             384


<210>  91
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI9 Vk (wt-nt)

<400>  91
gaaatcgtga tgacgcagtc tccagccacc ctgtctctat cttcagggga aagagccacc       60

ctctcctgca gggccagtcg gagtgttagt agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catttatgat gcatccacca gggccactgg tttttcagcc      180

aggttcgctg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattctg ctatttatta ctgtcagcag tataataact ggcctccgtg gacgttcggc      300

caagggacca aggtggaaat caaac                                            325


<210>  92
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9 VK (aa)

<400>  92

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Ser Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Arg Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Arg Ala Thr Gly Phe Ser Ala Arg Phe Ala Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Ser Ala Ile Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  93
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9 CDRL1(aa)

<400>  93

Arg Ser Val Ser Ser Asn 
1               5       


<210>  94
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9 CDRL2(aa)

<400>  94

Asp Ala Ser 
1           


<210>  95
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9 CDRL3(aa)

<400>  95

Gln Gln Tyr Asn Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210>  96
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI9 Vk (co-nt)

<400>  96
gagatcgtga tgacccagtc cccagccaca ctgagcctgt ccagcggaga gagggccacc       60

ctgtcctgca gggcttcccg gagcgtgtct tccaacctgg cctggtacca gcagaagcca      120

ggccaggctc ccagactgct gatctatgac gcctctacca gagctacagg cttctccgcc      180

aggtttgctg gatctggatc cggcacagag ttcaccctga caatcagctc tctgcagagc      240

gaggattctg ctatctacta ttgtcagcag tacaacaatt ggcccccttg gacctttggc      300

cagggcacaa aggtggagat caag                                             324


<210>  97
<211>  385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI10 VH (wt-nt)

<400>  97
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaagtc       60

tcctgcaagg cttctggagg caccttgagt agtcaagtta ttagctgggt gcgacaggcc      120

ccaggacaag gactggagtg gatcggaggg atcatcccca ccactggtac agggggcgcg      180

gcagaggggt tccagggcag agtctccatt tccgcggacg aatccaggag cacagtctac      240

atggaactga ccagcctgac ttctggggac acggccgtct attattgtgc gagagcggtt      300

tcggattact ttaatagaga cctcggctgg gaaaattact actttgaatc ttggggccag      360

ggaaccctgg tcaccgtctc ctcag                                            385


<210>  98
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI10 VH (aa)

<400>  98

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ser Ser Gln 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Thr Gly Thr Gly Gly Ala Ala Glu Gly Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Ile Ser Ala Asp Glu Ser Arg Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asn 
            100                 105                 110         


Tyr Tyr Phe Glu Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI10 CDRH1 (aa)

<400>  99

Gly Gly Thr Leu Ser Ser Gln Val 
1               5               


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI10 CDRH2 (aa)

<400>  100

Ile Ile Pro Thr Thr Gly Thr Gly 
1               5               


<210>  101
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI10 CDRH3 (aa)

<400>  101

Ala Arg Ala Val Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asn 
1               5                   10                  15      


Tyr Tyr Phe Glu Ser 
            20      


<210>  102
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI10 VH (co-nt)

<400>  102
caggtgcagc tggtgcagag cggagctgag gtgaagaagc caggctccag cgtgaaggtg       60

tcctgcaagg ctagcggcgg caccctgtct tcccaggtca tctcttgggt gaggcaggct      120

ccaggacagg gactggagtg gatcggcggc atcatcccta ccacaggcac aggcggagct      180

gctgagggat tccagggcag agtgtccatc agcgccgacg agtctcgctc caccgtgtac      240

atggagctga ccagcctgac atctggcgat acagccgtgt actattgtgc cagggccgtg      300

tccgactatt tcaaccggga tctgggctgg gagaattact attttgagtc ctggggccag      360

ggcaccctgg tgacagtgag ctct                                             384


<210>  103
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI10 Vk (wt-nt)

<400>  103
gaaatcgtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcttgca gggccagtcg gagtgttagt atcaacttag cctggtacca acagaaacct      120

ggccaggctc cccggctcct catttatgat gcatctacga gggccactgg catcccagcc      180

aggttcggtg gcagggggtc tggaacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattctg ctgtttatta ctgtcagcac tataataact ggcctccgtg gacattcggc      300

caagggacca gagtggaaat caaac                                            325


<210>  104
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI10 VK (aa)

<400>  104

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Arg Ser Val Ser Ile Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Gly Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Ser Ala Val Tyr Tyr Cys Gln His Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys 
            100                 105             


<210>  105
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI10 CDRL1(aa)

<400>  105

Arg Ser Val Ser Ile Asn 
1               5       


<210>  106
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI10 CDRL2(aa)

<400>  106

Asp Ala Ser 
1           


<210>  107
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI10 CDRL3(aa)

<400>  107

Gln His Tyr Asn Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210>  108
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI10 Vk (co-nt)

<400>  108
gagatcgtga tgacccagtc ccctgccaca ctgtccgtgt ccccaggaga gagagccacc       60

ctgagctgca gggctagcag gtccgtgtcc atcaacctgg cctggtacca gcagaagcca      120

ggccaggctc ccaggctgct gatctatgac gcttctacca gggctacagg catcccagct      180

agattcggag gaaggggatc cggaacagag tttaccctga caatctccag cctgcagagc      240

gaggattccg ccgtgtacta ttgtcagcac tacaacaatt ggccaccttg gaccttcggc      300

cagggaacac gcgtggagat caag                                             324


<210>  109
<211>  385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI12 VH (wt-nt)

<400>  109
caggtgcacc tggtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgagggtc       60

tcctgcaagg cttctggaga ctccttcaac aaatatgaag tcagctgggt gcgacaggcc      120

cccggacatg gacttgagtg gatgggaggg atcatccctc tctctcctat agcgaggtac      180

gcagagaaat ttcagggcag agtcacgatt accgcggacg aattcacgag cacggtctat      240

atacaactga ccagcctgag atctgacgac acggccgtat actactgtgc gacaacacgt      300

tcggattact ttaatagaga cctcggctgg gaagattact tctttgacca ctggggccag      360

ggaaccctgg tcaccgtctc ctcag                                            385


<210>  110
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI12 VH (aa)

<400>  110

Gln Val His Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Asp Ser Phe Asn Lys Tyr 
            20                  25                  30          


Glu Val Ser Trp Val Arg Gln Ala Pro Gly His Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Ser Pro Ile Ala Arg Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Phe Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Ile Gln Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Thr Arg Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asp 
            100                 105                 110         


Tyr Phe Phe Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  111
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI12 CDRH1 (aa)

<400>  111

Gly Asp Ser Phe Asn Lys Tyr Glu 
1               5               


<210>  112
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI12 CDRH2 (aa)

<400>  112

Ile Ile Pro Leu Ser Pro Ile Ala 
1               5               


<210>  113
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI12 CDRH3 (aa)

<400>  113

Ala Thr Thr Arg Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asp 
1               5                   10                  15      


Tyr Phe Phe Asp His 
            20      


<210>  114
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI12 VH (co-nt)

<400>  114
caggtgcacc tggtgcagtc tggcgccgag gtgaagaagc caggctccag cgtgagggtg       60

tcctgcaagg ctagcggcga ctctttcaac aagtacgagg tgagctgggt gagacaggct      120

ccaggacatg gactggagtg gatgggcggc atcatccccc tgtctcctat cgccagatac      180

gctgagaagt tccagggccg cgtgaccatc acagctgatg agtttacctc cacagtgtat      240

atccagctga cctccctgag gagcgacgat acagccgtgt actattgtgc taccacaagg      300

agcgactact ttaatcggga tctgggctgg gaggactatt tctttgatca ctggggccag      360

ggcaccctgg tgacagtgtc ttcc                                             384


<210>  115
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI12 Vk (wt-nt)

<400>  115
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtattagc accaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctctggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg gagtttatta ctgtcagcac tataataact ggcctccgtg gacgttcggc      300

caagggacca aggtggaaat caaac                                            325


<210>  116
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI12 VK (aa)

<400>  116

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Val Tyr Tyr Cys Gln His Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  117
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI12 CDRL1(aa)

<400>  117

Gln Ser Ile Ser Thr Asn 
1               5       


<210>  118
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI12 CDRL2(aa)

<400>  118

Gly Ala Ser 
1           


<210>  119
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI12 CDRL3(aa)

<400>  119

Gln His Tyr Asn Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210>  120
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI12 Vk (co-nt)

<400>  120
gagatcgtga tgacccagtc ccctgccaca ctgtccgtgt ccccaggaga gagggccacc       60

ctgagctgcc gggctagcca gtctatctcc acaaacctgg cctggtacca gcagaagcca      120

ggacaggctc caaggctgct gatcagcgga gcttctacca gagctacagg catcccagct      180

cgcttcagcg gatctggatc cggaaccgag tttaccctga caatctccag cctgcagtct      240

gaggacttcg gcgtgtacta ttgtcagcac tataacaatt ggcccccttg gacctttggc      300

cagggcacaa aggtggagat caag                                             324


<210>  121
<211>  385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI13 VH (wt-nt)

<400>  121
caggttcagc tggtgcaatc tggggctgag gtgaagaggc ctgggtcctc ggtgagggtc       60

tcctgcaagg gttctggaga caccttcaac aactatgtta tcagttgggt gcgacaggcc      120

cctggccaag ggcttgagtg gatggggggg atcatcccta tctttcaaac accaaactac      180

gcagagaagt tccagggcag agtcgcgatt accgcggacg aatccacgag cacggcctac      240

atggagttga gcagcctgag atctgaggac tcggccattt attactgtgc gagagcgaat      300

tccgattact ttaatagaga cctcggctgg gaaaattact actttgaaga ctggggccag      360

ggaaccctgg tcaccgtctc ctcag                                            385


<210>  122
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI13 VH (aa)

<400>  122

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Gly Ser Gly Asp Thr Phe Asn Asn Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gln Thr Pro Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asn Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asn 
            100                 105                 110         


Tyr Tyr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  123
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI13 CDRH1 (aa)

<400>  123

Gly Asp Thr Phe Asn Asn Tyr Val 
1               5               


<210>  124
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI13 CDRH2 (aa)

<400>  124

Ile Ile Pro Ile Phe Gln Thr Pro 
1               5               


<210>  125
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI13 CDRH3 (aa)

<400>  125

Ala Arg Ala Asn Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asn 
1               5                   10                  15      


Tyr Tyr Phe Glu Asp 
            20      


<210>  126
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI13 VH (co-nt)

<400>  126
caggtgcagc tggtgcagtc cggagctgag gtgaagaggc caggatccag cgtgcgggtg       60

agctgcaagg gatctggcga caccttcaac aattacgtga tcagctgggt gaggcaggct      120

ccaggacagg gactggagtg gatgggcggc atcatcccca tcttccagac ccctaactac      180

gctgagaagt ttcagggcag ggtggccatc acagctgacg agtccaccag cacagcctat      240

atggagctgt cttccctgag atctgaggat tccgctatct actattgtgc cagagctaac      300

tctgactatt tcaatcgcga tctgggctgg gagaattact attttgagga ttggggccag      360

ggcaccctgg tgacagtgag ctct                                             384


<210>  127
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI13 Vk (wt-nt)

<400>  127
gaaagagtga tgacgcagtc tccagccacc ctttctgtgt ctccaggggg aagagccacc       60

ctctcctgca gggccagtca gagtgttggt agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatgat gcttctgcca gggccactgg tgtcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttctctctct ccatcaacag cctgcagtct      240

gaagattctg cagtttatta ctgtcagcac tataatatct ggccgccgtg gacgttcggc      300

caagggacca aggtggaaat caaac                                            325


<210>  128
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI13 VK (aa)

<400>  128

Glu Arg Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Gly Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ala Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ser Leu Ser Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Ser Ala Val Tyr Tyr Cys Gln His Tyr Asn Ile Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  129
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI13 CDRL1(aa)

<400>  129

Gln Ser Val Gly Ser Asn 
1               5       


<210>  130
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI13 CDRL2(aa)

<400>  130

Asp Ala Ser 
1           


<210>  131
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI13 CDRL3(aa)

<400>  131

Gln His Tyr Asn Ile Trp Pro Pro Trp Thr 
1               5                   10  


<210>  132
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI13 Vk (co-nt)

<400>  132
gagagagtga tgacccagtc tcctgctaca ctgtccgtga gcccaggagg aagggctacc       60

ctgtcctgca gggcttctca gtccgtggga agcaacctgg cttggtacca gcagaagcca      120

ggccaggccc ccagactgct gatctatgac gcttccgcta gagctaccgg cgtgccagct      180

cgcttcagcg gatctggctc cggcacagag tttagcctgt ctatcaactc cctgcagagc      240

gaggattctg ccgtgtacta ttgtcagcac tacaatatct ggccaccttg gaccttcggc      300

cagggaacaa aggtggagat caag                                             324


<210>  133
<211>  385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI14 VH (wt-nt)

<400>  133
caagttcagt tggtgcagtc tggggctgag ctgaagcggc ctgggtcctc ggtgaggatc       60

tcctgcaagg cctctggtgt caccttcaac aagtatgttc tcagctgggt gcgactggcc      120

cctggacaag ggcttgagtg gatgggagga atcatcccta tttctggtat accacattac      180

gcagagaagt tccagggcag agtcgcgatt accgcggacg aatccacgag cacagtctac      240

atggagttga gcagcctacg atctgaggac tcggccctat attactgtgc gagagcggtc      300

tccgattatt ttaatcggga cctcggctgg gatgattact actttccttt gtggggccac      360

ggcaccctgg tcaccgtctc ctcag                                            385


<210>  134
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI14 VH (aa)

<400>  134

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Val Thr Phe Asn Lys Tyr 
            20                  25                  30          


Val Leu Ser Trp Val Arg Leu Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Ser Gly Ile Pro His Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Ile Thr Ala Asp Glu Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Asp Asp 
            100                 105                 110         


Tyr Tyr Phe Pro Leu Trp Gly His Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  135
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI14 CDRH1 (aa)

<400>  135

Gly Val Thr Phe Asn Lys Tyr Val 
1               5               


<210>  136
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI14 CDRH2 (aa)

<400>  136

Ile Ile Pro Ile Ser Gly Ile Pro 
1               5               


<210>  137
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI14 CDRH3 (aa)

<400>  137

Ala Arg Ala Val Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Asp Asp 
1               5                   10                  15      


Tyr Tyr Phe Pro Leu 
            20      


<210>  138
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI14 VH (co-nt)

<400>  138
caggtgcagc tggtgcagtc tggagctgag ctgaagaggc caggatccag cgtgcggatc       60

agctgcaagg cttctggcgt gaccttcaac aagtacgtgc tgtcctgggt gaggctggct      120

ccaggacagg gactggagtg gatgggcggc atcatcccca tcagcggcat ccctcactac      180

gctgagaagt ttcagggcag ggtggccatc acagctgacg agtccaccag cacagtgtat      240

atggagctgt cttccctgag atctgaggat tccgccctgt actattgtgc cagagccgtg      300

tccgactatt tcaatcgcga tctgggctgg gacgattact attttcccct gtggggccat      360

ggcaccctgg tgacagtgag ctct                                             384


<210>  139
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI14 Vk (wt-nt)

<400>  139
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagcgccacc       60

ctcttctgca gggccagtcg gagtgttagt gacaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctttggt gcttccacca gggccactgg tgtcccagcc      180

aggttcggtg gcagtgggtc tgggacacag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcat tataataact ggcctccgtg gacgttcggc      300

caagggacca aggtggagat caaac                                            325


<210>  140
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI14 VK (aa)

<400>  140

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Phe Cys Arg Ala Ser Arg Ser Val Ser Asp Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Gly Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  141
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI14 CDRL1(aa)

<400>  141

Arg Ser Val Ser Asp Asn 
1               5       


<210>  142
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI14 CDRL2(aa)

<400>  142

Gly Ala Ser 
1           


<210>  143
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI14 CDRL3(aa)

<400>  143

Gln His Tyr Asn Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210>  144
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI14 Vk (co-nt)

<400>  144
gagatcgtga tgacccagtc ccctgccaca ctgtccgtgt ccccaggaga gagcgccacc       60

ctgttctgca gggctagcag gtccgtgtcc gacaacctgg cctggtacca gcagaagcca      120

ggccaggctc ccaggctgct gatctttggc gcctctacca gagctacagg cgtgccagct      180

aggttcggag gaagcggatc tggcacacag tttaccctga caatctccag cctgcagtcc      240

gaggatttcg ccgtgtacta ttgtcagcac tataacaatt ggcccccttg gacctttggc      300

cagggcacaa aggtggagat caag                                             324


<210>  145
<211>  385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI17 VH (wt-nt)

<400>  145
caggttcaac tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgcaagc cttccggagg caccttcagc aacaatgtta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccca cctctggtat agcaaactac      180

gcgcagaagt tccagggcag agtcgcgatt attgcggaca aatctacgag cacagtctac      240

atggcgttga gcagcctgag atctgaggac tcggccgtgt atttctgtgc cagagcgcgg      300

tccgactact tcaatagaga cctcggctgg gaagattact actttgagaa ctggggccag      360

ggaaccctgg tcaccgtctc ctcag                                            385


<210>  146
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI17 VH (aa)

<400>  146

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser Gly Gly Thr Phe Ser Asn Asn 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Ser Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Ile Ile Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Ala Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Arg Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asp 
            100                 105                 110         


Tyr Tyr Phe Glu Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  147
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI17 CDRH1 (aa)

<400>  147

Gly Gly Thr Phe Ser Asn Asn Val 
1               5               


<210>  148
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI17 CDRH2 (aa)

<400>  148

Ile Ile Pro Thr Ser Gly Ile Ala 
1               5               


<210>  149
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI17 CDRH3 (aa)

<400>  149

Ala Arg Ala Arg Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asp 
1               5                   10                  15      


Tyr Tyr Phe Glu Asn 
            20      


<210>  150
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI17 VH (co-nt)

<400>  150
caggtgcagc tggtgcagtc cggagctgag gtgaagaggc caggctccag cgtgaaggtg       60

agctgcaagc cttctggcgg caccttctcc aacaatgtga tcagctgggt gagacaggct      120

ccaggacagg gactggagtg gatgggagga atcatcccca catctggcat cgccaactac      180

gctcagaagt ttcagggcag ggtggccatc atcgctgata agtccaccag cacagtgtat      240

atggccctgt cttccctgag atctgaggac tccgccgtgt acttctgtgc cagggctcgg      300

tccgactact tcaaccgcga tctgggctgg gaggactact atttcgagaa ttggggccag      360

ggcaccctgg tgacagtgag ctct                                             384


<210>  151
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI17 Vk (wt-nt)

<400>  151
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttggc agcagcttag tctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tgtcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcac tataataact ggcctccgtg gacgttcggc      300

caagggacca aggtggaaat caaac                                            325


<210>  152
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI17 VK (aa)

<400>  152

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  153
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI17 CDRL1(aa)

<400>  153

Gln Ser Val Gly Ser Ser 
1               5       


<210>  154
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI17 CDRL2(aa)

<400>  154

Gly Ala Ser 
1           


<210>  155
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI17 CDRL3(aa)

<400>  155

Gln His Tyr Asn Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210>  156
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI17 Vk (co-nt)

<400>  156
gagatcgtga tgacccagtc tcctgccaca ctgagcgtgt ctccaggaga gagggccacc       60

ctgtcctgca gggcttccca gagcgtggga tccagcctgg tgtggtacca gcagaagcca      120

ggacaggctc caaggctgct gatctatgga gctagcacca gagctacagg cgtgccagct      180

cgcttctctg gatccggaag cggcacagag tttaccctga caatctcttc cctgcagtct      240

gaggacttcg ccgtgtacta ttgtcagcac tacaacaatt ggcccccttg gacctttggc      300

cagggcacaa aggtggagat caag                                             324


<210>  157
<211>  385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI19 VH (wt-nt)

<400>  157
caagttcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgagggtc       60

tcctgcaagg cttctgaagg caccttcaac aagtatactc tcacctgggt gcgacaggcc      120

cctggacagg gacttgagtg gatgggagga atcatcccta tctccggtat agcaaactac      180

gcacagaagt tccagggcag agtcgcgatt accgcggacg aatccacgac cacagcctac      240

atggaattga gcagcctaag atctgaagac tcggccgtat attactgtgc gacagcggtc      300

tccgattatt ttaatcgaga cctcggctgg gaagattact actttccgtt ctggggccag      360

ggcaccctgg tcaccgtcgc ctcag                                            385


<210>  158
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI19 VH (aa)

<400>  158

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Glu Gly Thr Phe Asn Lys Tyr 
            20                  25                  30          


Thr Leu Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Ser Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Val Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asp 
            100                 105                 110         


Tyr Tyr Phe Pro Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ala Ser 
        115                 120                 125             


<210>  159
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI19 CDRH1 (aa)

<400>  159

Glu Gly Thr Phe Asn Lys Tyr Thr 
1               5               


<210>  160
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI19 CDRH2 (aa)

<400>  160

Ile Ile Pro Ile Ser Gly Ile Ala 
1               5               


<210>  161
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI19 CDRH3 (aa)

<400>  161

Ala Thr Ala Val Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asp 
1               5                   10                  15      


Tyr Tyr Phe Pro Phe 
            20      


<210>  162
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI19 VH (co-nt)

<400>  162
caggtgcagc tggtgcagtc cggagctgag gtgaagaggc caggatccag cgtgcgggtg       60

tcctgcaagg ctagcgaggg cacattcaac aagtacacac tgacctgggt gaggcaggct      120

ccaggacagg gactggagtg gatgggcggc atcatcccta tctctggcat cgccaattac      180

gctcagaagt ttcagggcag agtggccatc acagctgatg agtccaccac aaccgcctat      240

atggagctgt cttccctgag aagcgaggac tccgccgtgt actattgtgc caccgctgtg      300

agcgactatt tcaaccgcga tctgggctgg gaggactact atttcccctt ttggggccag      360

ggcacactgg tgaccgtggc ttct                                             384


<210>  163
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI19 Vk (wt-nt)

<400>  163
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccgggggc cagagccacc       60

ctcttctgca gggccagtcg gagtgttagt gacaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctttggt gcatccacca gggccactgg tgtcccagcc      180

aggttcagtg gaagtgggtc tgggacacag ttcactctca ccatcagcag cctgcagtcc      240

gaagattttg cagtttatta ctgtcagcat tataatattt ggcctccgtg gacgttcggc      300

caagggacca aggtggagat caaac                                            325


<210>  164
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI19 VK (aa)

<400>  164

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Ala Arg Ala Thr Leu Phe Cys Arg Ala Ser Arg Ser Val Ser Asp Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asn Ile Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  165
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI19 CDRL1(aa)

<400>  165

Arg Ser Val Ser Asp Asn 
1               5       


<210>  166
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI19 CDRL2(aa)

<400>  166

Gly Ala Ser 
1           


<210>  167
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI19 CDRL3(aa)

<400>  167

Gln His Tyr Asn Ile Trp Pro Pro Trp Thr 
1               5                   10  


<210>  168
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI19 Vk (co-nt)

<400>  168
gagatcgtga tgacccagtc ccctgctaca ctgtccgtgt ccccaggagc tagggctacc       60

ctgttctgca gggctagcag gtccgtgtcc gacaacctgg cttggtacca gcagaagcca      120

ggccaggccc ccagactgct gatctttgga gctagcacca gagctacagg cgtgccagct      180

cgcttcagcg gatctggatc cggcacacag tttaccctga caatctccag cctgcagtct      240

gaggatttcg ccgtgtacta ttgtcagcac tataatatct ggcccccttg gacctttggc      300

cagggcacaa aggtggagat caag                                             324


<210>  169

<400>  169
000

<210>  170
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI3-VH-W110F (nt)

<400>  170
caggtgcagc tggtgcagtc cggagctgag gtgaagaggc caggatccag cgtgaaggtg       60

tcctgcaagg ccagcggcgc taccttcagc aacaatgtga tcgcttgggt gagacaggct      120

ccaggacagg gactggagtg gatgggagga atccacccta tcagcgccac cgctacatac      180

gcccagaagt ttcagggcag agtggctatc gccgctgacg agctgacctc tacagcctat      240

atggagctga acggcctgcg cagcgaggat tccgccgtgt actattgtgc cagggctggc      300

tctgactact tcaaccggga tctgggcttc gagaattact attttgactc ctggggccag      360

ggcaccctgg tgacagtgtc ttcc                                             384


<210>  171
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI3-VH-W110F (aa)

<400>  171

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ala Thr Phe Ser Asn Asn 
            20                  25                  30          


Val Ile Ala Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile His Pro Ile Ser Ala Thr Ala Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Ile Ala Ala Asp Glu Leu Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Gly Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Ser Asp Tyr Phe Asn Arg Asp Leu Gly Phe Glu Asn 
            100                 105                 110         


Tyr Tyr Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  172
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI3-VH-W110F CDRH3 (aa)

<400>  172

Ala Arg Ala Gly Ser Asp Tyr Phe Asn Arg Asp Leu Gly Phe Glu Asn 
1               5                   10                  15      


Tyr Tyr Phe Asp Ser 
            20      


<210>  173
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI3-VK-W94F (nt)

<400>  173
gagatcctga tgacccagtc ccctgccaca ctgtccgtgt ccccaggaga gagggccacc       60

ctgagctgca gggcttctca ggacgtgtcc ggcaacctgg cctggtacca gcagagacca      120

ggacaggctc caaggctgct gatctatgga gcttccacca gggctacagg cgtgccagct      180

agattcaccg gcgctggaag cggcacagag tttaccctga caatctccag cctgcagtct      240

gaggatttcg ctctgtacta ttgtcagcac tacaacaatt ttcccccttg gacctttggc      300

cagggcacaa aggtggagat caag                                             324


<210>  174
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI3-VK-W94F (aa)

<400>  174

Glu Ile Leu Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Val Ser Gly Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Thr Gly 
    50                  55                  60                  


Ala Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Leu Tyr Tyr Cys Gln His Tyr Asn Asn Phe Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  175
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI3-VK-W94F CDRL3 (aa)

<400>  175

Gln His Tyr Asn Asn Phe Pro Pro Trp Thr 
1               5                   10  


<210>  176
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI3-VK-W97F (nt)

<400>  176
gagatcctga tgacccagtc ccctgccaca ctgtccgtgt ccccaggaga gagggccacc       60

ctgagctgca gggcttctca ggacgtgtcc ggcaacctgg cctggtacca gcagagacca      120

ggacaggctc caaggctgct gatctatgga gcttccacca gggctacagg cgtgccagct      180

agattcaccg gcgctggaag cggcacagag tttaccctga caatctccag cctgcagtct      240

gaggatttcg ctctgtacta ttgtcagcac tacaacaatt ggcccccttt cacctttggc      300

cagggcacaa aggtggagat caag                                             324


<210>  177
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI3-VK-W97F (aa)

<400>  177

Glu Ile Leu Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Val Ser Gly Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Thr Gly 
    50                  55                  60                  


Ala Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Leu Tyr Tyr Cys Gln His Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  178
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI3-VK-W97F CDRL3 (aa)

<400>  178

Gln His Tyr Asn Asn Trp Pro Pro Phe Thr 
1               5                   10  


<210>  179
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI3-VK-W94F-W97F (nt)

<400>  179
gagatcctga tgacccagtc ccctgccaca ctgtccgtgt ccccaggaga gagggccacc       60

ctgagctgca gggcttctca ggacgtgtcc ggcaacctgg cctggtacca gcagagacca      120

ggacaggctc caaggctgct gatctatgga gcttccacca gggctacagg cgtgccagct      180

agattcaccg gcgctggaag cggcacagag tttaccctga caatctccag cctgcagtct      240

gaggatttcg ctctgtacta ttgtcagcac tacaacaatt ttcccccttt cacctttggc      300

cagggcacaa aggtggagat caag                                             324


<210>  180
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI3-VK-W94F-W97F (aa)

<400>  180

Glu Ile Leu Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Val Ser Gly Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Thr Gly 
    50                  55                  60                  


Ala Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Leu Tyr Tyr Cys Gln His Tyr Asn Asn Phe Pro Pro 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  181
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI3-VK-W94F-W97F CDRL3 (aa)

<400>  181

Gln His Tyr Asn Asn Phe Pro Pro Phe Thr 
1               5                   10  


<210>  182
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI9-VH-W110F (nt)

<400>  182
caggtgcacc tggtgcagag cggagctgag gtgaaggagc caggatccag cgtgacagtg       60

tcttgcaagg cttccggcgg cagcttcaac aatcaggcta tctcctgggt gaggcaggct      120

ccaggacagg gactggagtg gatgggcggc atctttccca tctctggcac acctacctcc      180

gcccagaggt tccagggaag ggtgaccttc accgctgacg agagcaccac aaccgtgtac      240

atggatctgt cttccctgag atctgacgat accgccgtgt actattgtgc cagagctggc      300

tccgactatt tcaaccgcga tctgggcttc gagaattact attttgcttc ctggggccag      360

ggcacactgg tgaccgtgag ctct                                             384


<210>  183
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9-VH-W110F (aa)

<400>  183

Gln Val His Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Asn Asn Gln 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Phe Pro Ile Ser Gly Thr Pro Thr Ser Ala Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Ser Asp Tyr Phe Asn Arg Asp Leu Gly Phe Glu Asn 
            100                 105                 110         


Tyr Tyr Phe Ala Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  184
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9-VH-W110F CDRH3 (aa)

<400>  184

Ala Arg Ala Gly Ser Asp Tyr Phe Asn Arg Asp Leu Gly Phe Glu Asn 
1               5                   10                  15      


Tyr Tyr Phe Ala Ser 
            20      


<210>  185
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI9-VK-W94F (nt)

<400>  185
gagatcgtga tgacccagtc cccagccaca ctgagcctgt ccagcggaga gagggccacc       60

ctgtcctgca gggcttcccg gagcgtgtct tccaacctgg cctggtacca gcagaagcca      120

ggccaggctc ccagactgct gatctatgac gcctctacca gagctacagg cttctccgcc      180

aggtttgctg gatctggatc cggcacagag ttcaccctga caatcagctc tctgcagagc      240

gaggattctg ctatctacta ttgtcagcag tacaacaatt tccccccttg gacctttggc      300

cagggcacaa aggtggagat caag                                             324


<210>  186
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9-VK-W94F (aa)

<400>  186

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Ser Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Arg Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Arg Ala Thr Gly Phe Ser Ala Arg Phe Ala Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Ser Ala Ile Tyr Tyr Cys Gln Gln Tyr Asn Asn Phe Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  187
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9-VK-W94F CDRL3 (aa)

<400>  187

Gln Gln Tyr Asn Asn Phe Pro Pro Trp Thr 
1               5                   10  


<210>  188
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI9-VK-W97F (nt)

<400>  188
gagatcgtga tgacccagtc cccagccaca ctgagcctgt ccagcggaga gagggccacc       60

ctgtcctgca gggcttcccg gagcgtgtct tccaacctgg cctggtacca gcagaagcca      120

ggccaggctc ccagactgct gatctatgac gcctctacca gagctacagg cttctccgcc      180

aggtttgctg gatctggatc cggcacagag ttcaccctga caatcagctc tctgcagagc      240

gaggattctg ctatctacta ttgtcagcag tacaacaatt ggcccccttt cacctttggc      300

cagggcacaa aggtggagat caag                                             324


<210>  189
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9-VK-W97F (aa)

<400>  189

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Ser Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Arg Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Arg Ala Thr Gly Phe Ser Ala Arg Phe Ala Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Ser Ala Ile Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  190
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9-VK-W97F CDRL3 (aa)

<400>  190

Gln Gln Tyr Asn Asn Trp Pro Pro Phe Thr 
1               5                   10  


<210>  191
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI9-VK-W94F-W97F (nt)

<400>  191
gagatcgtga tgacccagtc cccagccaca ctgagcctgt ccagcggaga gagggccacc       60

ctgtcctgca gggcttcccg gagcgtgtct tccaacctgg cctggtacca gcagaagcca      120

ggccaggctc ccagactgct gatctatgac gcctctacca gagctacagg cttctccgcc      180

aggtttgctg gatctggatc cggcacagag ttcaccctga caatcagctc tctgcagagc      240

gaggattctg ctatctacta ttgtcagcag tacaacaatt ttcccccttt cacctttggc      300

cagggcacaa aggtggagat caag                                             324


<210>  192
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9-VK-W94F-W97F (aa)

<400>  192

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Ser Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Arg Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Arg Ala Thr Gly Phe Ser Ala Arg Phe Ala Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Ser Ala Ile Tyr Tyr Cys Gln Gln Tyr Asn Asn Phe Pro Pro 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  193
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9-VK-W94F-W97F CDRL3 (aa)

<400>  193

Gln Gln Tyr Asn Asn Phe Pro Pro Phe Thr 
1               5                   10  


<210>  194
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FM08 VH

<400>  194

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Tyr 
            20                  25                  30          


Asn Ala Val Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Gly Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Glu Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Ser Gly His Ile Thr Val Phe Gly Val Asn Val 
            100                 105                 110         


Asp Ala Phe Asp Met Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125             


<210> 195
<211> 103
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FM08 VL

<400> 195
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Leu Ser Ser Tyr
            20                  25                  30
Thr His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45
Tyr Ala Ala Ser Ser Arg Gly Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Thr Phe Gly Gln
                85                  90                  95
Gly Thr Lys Val Glu Ile Lys
            100


<210>  196
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT hIgG1 Fc

<400>  196

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  197
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric hinge sequence

<400>  197

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro 
            


<210>  198
<211>  386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI17-v19-VH (co-nt)

<400>  198
caggtccagc tggtccagag tggggcagag gtcaaagagc cagggtcttc agtcacagtc       60

tcatgcaaag caagcggagg aacattttcc aacaatgtga tcagctgggt gaggcaggct      120

ccaggacagg gactggagtg gatgggcggc atcatcccta cctctggcat cgccaactac      180

gctcagaagt tccagggcag agtggccatc atcgctgaca agtctacctc cacagtgtat      240

atggccctgt ccagcctgag aagcgaggat tccgccgtgt acttctgcgc cagggctcgg      300

tccgactact tcaaccgcga tctgggttgg gaggactatt actttgaaaa ctgggggcag      360

ggcacactgg tcactgtctc atcagc                                           386


<210>  199
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI17-v19-VH (aa)

<400>  199

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Asn 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Ser Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Ile Ile Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Ala Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Arg Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asp 
            100                 105                 110         


Tyr Tyr Phe Glu Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  200
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI17-v19-VK (co-nt)

<400>  200
gaaattgtga tgacccagtc tccagccact ctgtcagtct ctccagggga acgagccact       60

ctgtcatgtc gggcctctca gtccgtcggc tccagcctgg cttggtacca gcagaagcca      120

ggacaggctc ctaggctgct gatctatgga gctagcacca gggctacagg cgtgccagct      180

cggttcagcg gatctggatc cggcaccgag tttaccctga caatctcttc cctgcagtct      240

gaggacttcg ccgtgtacta ttgccagcac tacaataact ggcctccttg gacattcggg      300

caggggacaa aagtcgagat taag                                             324


<210>  201
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI17-v19-VK (aa)

<400>  201

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  202
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI19-v3-VH (co-nt)

<400>  202
caggtccagc tggtgcagag tggtgccgag gtcaaaaagc cagggtcaag tgtcaaagtc       60

agttgtaaag catcagaggg aacattcaac aagtacacaa tcagctgggt gagacaggct      120

ccaggacagg gactggagtg gatgggcggc atcatcccta tctctggcat cgccaattac      180

gctcagaagt tccagggccg cgtggccatc acagctgacg agtccaccac aaccgcctat      240

atggagctgt ccagcctgag gtctgaggat tccgccgtgt actattgcgc caccgctgtg      300

agcgactact tcaaccggga tctgggctgg gaggactatt attttccatt ctggggtcag      360

gggacactgg tcaccgtctc ttcc                                             384


<210>  203
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI19-v3-VH (aa)

<400>  203

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Glu Gly Thr Phe Asn Lys Tyr 
            20                  25                  30          


Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Ser Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Val Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asp 
            100                 105                 110         


Tyr Tyr Phe Pro Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  204
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI19-v3-VK (co-nt)

<400>  204
gagatcgtga tgacccagtc ccctgctaca ctgtccgtgt ccccaggagc tagggctacc       60

ctgttctgca gggctagcag gtccgtgtcc gacaacctgg cttggtacca gcagaagcca      120

ggccaggccc ccagactgct gatctttgga gctagcacca gagctacagg cgtgccagct      180

cgcttcagcg gatctggatc cggcacacag tttaccctga caatctccag cctgcagtct      240

gaggatttcg ccgtgtacta ttgtcagcac tataatatct ggcccccttg gacctttggc      300

cagggcacaa aggtggagat caag                                             324


<210>  205
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI19-v3-VK (aa)

<400>  205

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Ala Arg Ala Thr Leu Phe Cys Arg Ala Ser Arg Ser Val Ser Asp Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asn Ile Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  206
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI9-v5-VH (co-nt)

<400>  206
caggtgcacc tggtgcagag cggagctgag gtgaaggagc caggatccag cgtgacagtg       60

tcttgcaagg cttccggcgg cagcttcaac aatcaggcta tctcctgggt gaggcaggct      120

ccaggacagg gactggagtg gatgggcggc atctttccca tctctggcac acctacctcc      180

gcccagaggt tccagggaag ggtgaccttc accgctgacg agagcaccac aaccgtgtac      240

atggatctgt cttccctgag atctgacgat accgccgtgt actattgtgc cagagctggc      300

tccgactatt tcaaccgcga tctgggctgg gagaattact attttgcttc ctggggccag      360

ggcacactgg tgaccgtgag ctct                                             384


<210>  207
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9-v5-VH (aa)

<400>  207

Gln Val His Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Asn Asn Gln 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Phe Pro Ile Ser Gly Thr Pro Thr Ser Ala Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asn 
            100                 105                 110         


Tyr Tyr Phe Ala Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  208
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FNI9-v5-VK (co-nt)

<400>  208
gagattgtga tgacccagtc ccctgctacc ctgagcgtgt cccccggaga gagagctacc       60

ctgagttgcc gcgccagccg cagtgtctct gacaacctgg cttggtacca gcagaagcca      120

ggacaggctc ctaggctgct gatctatggc gcctccacca gggctacagg catcccagct      180

cggttctctg gatccggaag cggcaccgag tttaccctga caatctccag cctgcagagc      240

gaggatttcg ccgtgtacta ttgccagcat tacaacatct ggcctccttg gacattcggt      300

cagggaacta aagtggaaat taag                                             324


<210>  209
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI9-v5-VK (aa)

<400>  209

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Arg Ser Val Ser Asp Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asn Ile Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  210
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgHG1*01, G1m3 CH1-CH3 with M428L and N434S mutations and 
       C-terminal lysine

<400>  210

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  211
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kappa light chain CL

<400>  211

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  212
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI17-v19 heavy chain with M428L and N434S mutations in CH3 and a
       C-terminal lysine

<400>  212

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Asn 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Ser Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Ile Ile Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Ala Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Arg Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asp 
            100                 105                 110         


Tyr Tyr Phe Glu Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        355                 360                 365             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  213
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI17-v19 heavy chain with M428L and N434S mutations in CH3, 
       without C-terminal lysine

<400>  213

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Asn 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Ser Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Ile Ile Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Ala Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Arg Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asp 
            100                 105                 110         


Tyr Tyr Phe Glu Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        355                 360                 365             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455         


<210>  214
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNI17-v19 light chain

<400>  214

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  215
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgHG1*01, G1m3 CH1-CH3 with M428L and N434S mutations, without 
       C-terminal lysine

<400>  215

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 

<210> 216
<211> 128
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI17-v13 VH

<400> 216
Gln Val Gln Leu Val Gln Ser Gly Ala Arg Val Lys Glu Pro Gly Ser
 1               5                  10                  15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Asn
            20                  25                  30
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45
Gly Gly Ile Ile Pro Thr Ser Gly Ile Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60
Gln Gly Arg Val Ala Ile Ile Ala Asp Lys Ser Thr Ser Thr Val Tyr
65                  70                  75                  80
Met Ala Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95
Ala Arg Ala Arg Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asp
            100                 105                 110
Tyr Tyr Phe Glu Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 217
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI17-v13 VK

<400> 217
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser
            20                  25                  30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asn Asn Trp Pro Pro
                85                  90                  95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 218
<211> 407
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Codon-optimized nucleotide
      sequence encoding FNI17-v19-VH with N-terminal
      amino acids T-G-V-H-S and C-terminal amino acids
      A-S

<400> 218
accggtgtac attctcaggt ccagctggtc cagagtgggg cagaggtcaa agagccaggg      60
tcttcagtca cagtctcatg caaagcaagc ggaggaacat tttccaacaa tgtgatcagc     120
tgggtgaggc aggctccagg acagggactg gagtggatgg gcggcatcat ccctacctct     180
ggcatcgcca actacgctca gaagttccag ggcagagtgg ccatcatcgc tgacaagtct     240
acctccacag tgtatatggc cctgtccagc ctgagaagcg aggattccgc cgtgtacttc     300
tgcgccaggg ctcggtccga ctacttcaac cgcgatctgg gttgggagga ctattacttt     360
gaaaactggg ggcagggcac actggtcact gtctcatcag cgtcgac                   407

<210> 219
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI antibody consensus CDRH3
      amino acid sequence

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = R or T

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = A or T

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = V, G, H, R, or N

<220> 
<221> VARIANT        
<222> 14
<223> Xaa = W or F

<220> 
<221> VARIANT        
<222> 15
<223> Xaa = D or E

<220> 
<221> VARIANT        
<222> 16
<223> Xaa = D or N

<220> 
<221> VARIANT        
<222> 18
<223> Xaa = Y or F

<220> 
<221> VARIANT        
<222> 20
<223> Xaa = P, D, E, or A

<220> 
<221> VARIANT        
<222> 21
<223> Xaa = L, I, S, Y, H, D, N, or F

<400> 219
Ala Xaa Xaa Xaa Ser Asp Tyr Phe Asn Arg Asp Leu Gly Xaa Xaa Xaa
 1               5                  10                  15
Tyr Xaa Phe Xaa Xaa
            20

<210> 220
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI antibody consensus CDRH1
      amino acid sequence

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = G or E

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = D, A, G, or V

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = T or S

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = F or L

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = N or S

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = N, R, K, or S

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Y, H, Q, or N

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = V, T, A, or E

<400> 220
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5

<210> 221
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI antibody consensus CDRH2
      amino acid sequence

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = I, H, L, or F

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = P or A

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = I, V, L, or T

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = S, T, or F

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = G, A, R, P, or Q

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = I, K, R, or T

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = P, T, A, or G

<400> 221
Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5

<210> 222
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI antibody consensus CDRL1
      amino acid sequence

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Q or R

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = T, S or D

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = V or I

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = S or G

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = S, G, I, T, or D

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = N, D, H, or S

<400> 222
Xaa Xaa Xaa Xaa Xaa Xaa
 1               5

<210> 223
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI antibody consensus CDRL2
      amino acid sequence

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = G or D

<400> 223
Xaa Ala Ser
 1

<210> 224
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI antibody consensus CDRL3
      amino acid sequence

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Q or H

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = N, T, or I

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = W or F

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = W or F;

<400> 224
Gln Xaa Tyr Asn Xaa Xaa Pro Pro Xaa Thr
 1               5                  10

<210> 225

<400> 225
 000

<210> 226

<400> 226
 000

<210> 227
<211> 384
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI-UCA-IGH

<400> 227
caggtgcagc tggtgcagtc tggcgccgag gtgaagaagc caggctccag cgtgaaggtg      60
agctgcaagg cttctggcgg caccttctct tcctacgcta tctcctgggt gaggcaggct     120
ccaggacagg gactggagtg gatgggcggc atcatcccta tcttcggcac agccaactac     180
gctcagaagt ttcagggcag agtgaccatc acagccgacg agtctacctc cacagcttat     240
atggagctga gctctctgcg ctccgaggat accgccgtgt actattgtgc cagggctggc     300
agcgactact tcaaccggga tctgggctgg gagaattact attttgacta ttggggccag     360
ggcaccctgg tgacagtgtc cagc                                            384

<210> 228
<211> 128
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI-UCA VH

<400> 228
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
            20                  25                  30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Ala Gly Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asn
            100                 105                 110
Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 229
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI-UCA-IGK

<400> 229
gagatcgtga tgacccagtc tcctgccaca ctgagcgtgt ctccaggaga gagggccacc      60
ctgtcctgca gggcttccca gagcgtgtcc agcaacctgg cctggtacca gcagaagcca     120
ggccaggctc ccaggctgct gatctatggc gccagcacca gagctacagg catcccagct     180
cgcttctctg gatccggaag cggcacagag tttaccctga caatctcttc cctgcagtct     240
gaggacttcg ccgtgtacta ttgtcagcag tacaacaatt ggcccccttg gacctttggc     300
cagggcacaa aggtggagat caag                                            324

<210> 230
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI-UCA VK

<400> 230
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
            20                  25                  30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro
                85                  90                  95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 231
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI-UCA CDRH1

<400> 231
Gly Gly Thr Phe Ser Ser Tyr Ala
 1               5

<210> 232
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI-UCA CDRH2

<400> 232
Ile Ile Pro Ile Phe Gly Thr Ala
 1               5

<210> 233
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI-UCA CDRH3

<400> 233
Ala Arg Ala Gly Ser Asp Tyr Phe Asn Arg Asp Leu Gly Trp Glu Asn
 1               5                  10                  15
Tyr Tyr Phe Asp Tyr
            20

<210> 234
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI-UCA CDRL1

<400> 234
Gln Ser Val Ser Ser Asn
 1               5

<210> 235
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI-UCA CDRL2

<400> 235
Gly Ala Ser
 1

<210> 236
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence FNI-UCA CDRL3

<400> 236
Gln Gln Tyr Asn Asn Trp Pro Pro Trp Thr
 1               5                  10

