                               SEQUENCE LISTING

<110> BIOGEN MA INC.
 
<120> VIRAL VECTOR POTENCY ASSAY

<130> 2011256-0944

<140> PCT/US2021/060056
<141> 2021-11-19

<150> 63/116,472
<151> 2020-11-20

<160> 23    

<170> PatentIn version 3.5

<210> 1
<211> 648
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1
Met Ala Asp Thr Leu Pro Ser Glu Phe Asp Val Ile Val Ile Gly Thr 
1               5                   10                  15      


Gly Leu Pro Glu Ser Ile Ile Ala Ala Ala Cys Ser Arg Ser Gly Arg 
            20                  25                  30          


Arg Val Leu His Val Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala 
        35                  40                  45              


Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Glu 
    50                  55                  60                  


Asn Ser Asp Ile Val Ser Asp Ser Pro Val Trp Gln Asp Gln Ile Leu 
65                  70                  75                  80  


Glu Asn Glu Glu Ala Ile Ala Leu Ser Arg Lys Asp Thr Ile Gln His 
                85                  90                  95      


Val Glu Val Phe Cys Tyr Ala Ser Gln Asp Leu His Glu Asp Val Glu 
            100                 105                 110         


Glu Ala Gly Ala Leu Gln Lys Asn His Ala Leu Val Thr Ser Ala Asn 
        115                 120                 125             


Ser Thr Glu Ala Ala Asp Ser Ala Phe Leu Pro Thr Glu Asp Glu Ser 
    130                 135                 140                 


Leu Ser Thr Met Ser Cys Glu Met Leu Thr Glu Gln Thr Pro Ser Ser 
145                 150                 155                 160 


Asp Pro Glu Asn Ala Leu Glu Val Asn Gly Ala Glu Val Thr Gly Glu 
                165                 170                 175     


Lys Glu Asn His Cys Asp Asp Lys Thr Cys Val Pro Ser Thr Ser Ala 
            180                 185                 190         


Glu Asp Met Ser Glu Asn Val Pro Ile Ala Glu Asp Thr Thr Glu Gln 
        195                 200                 205             


Pro Lys Lys Asn Arg Ile Thr Tyr Ser Gln Ile Ile Glu Gly Arg Arg 
    210                 215                 220                 


Phe Asn Ile Asp Leu Val Ser Lys Leu Leu Tyr Ser Arg Gly Leu Leu 
225                 230                 235                 240 


Ile Asp Leu Leu Ile Lys Ser Asn Val Ser Arg Tyr Ala Glu Phe Asn 
                245                 250                 255     


Ile Thr Arg Ile Leu Ala Phe Arg Glu Gly Arg Val Glu Gln Val Pro 
            260                 265                 270         


Cys Ser Arg Ala Asp Val Phe Asn Ser Lys Gln Leu Thr Met Val Glu 
        275                 280                 285             


Lys Arg Met Leu Met Lys Phe Leu Thr Phe Cys Met Glu Tyr Glu Lys 
    290                 295                 300                 


Tyr Pro Asp Glu Tyr Gly Tyr Glu Glu Ile Thr Phe Tyr Glu Tyr Leu 
305                 310                 315                 320 


Lys Thr Gln Lys Leu Thr Pro Asn Leu Gln Tyr Ile Val Met His Ser 
                325                 330                 335     


Ile Ala Met Thr Ser Glu Thr Ala Ser Ser Thr Ile Asp Gly Leu Lys 
            340                 345                 350         


Ala Thr Lys Asn Phe Leu His Cys Leu Gly Arg Tyr Gly Asn Thr Pro 
        355                 360                 365             


Phe Leu Phe Pro Leu Tyr Gly Gln Gly Glu Leu Pro Gln Cys Phe Cys 
    370                 375                 380                 


Arg Met Cys Ala Val Phe Gly Gly Ile Tyr Cys Leu Arg His Ser Val 
385                 390                 395                 400 


Gln Cys Leu Val Val Asp Lys Glu Ser Arg Lys Cys Lys Ala Ile Ile 
                405                 410                 415     


Asp Gln Phe Gly Gln Arg Ile Ile Ser Glu His Phe Leu Val Glu Asp 
            420                 425                 430         


Ser Tyr Phe Pro Glu Asn Met Cys Ser Arg Val Gln Tyr Arg Gln Ile 
        435                 440                 445             


Ser Arg Ala Val Leu Ile Thr Asp Arg Ser Val Leu Thr Asp Ser Asp 
    450                 455                 460                 


Gln Gln Ile Ser Ile Leu Thr Val Pro Ala Glu Glu Pro Gly Thr Phe 
465                 470                 475                 480 


Ala Val Arg Val Ile Glu Leu Cys Ser Ser Thr Met Thr Cys Met Lys 
                485                 490                 495     


Gly Thr Tyr Leu Val His Leu Thr Cys Thr Ser Ser Lys Thr Ala Arg 
            500                 505                 510         


Glu Asp Leu Glu Ser Val Val Gln Lys Leu Phe Val Pro Tyr Thr Glu 
        515                 520                 525             


Met Glu Ile Glu Asn Glu Gln Val Glu Lys Pro Arg Ile Leu Trp Ala 
    530                 535                 540                 


Leu Tyr Phe Asn Met Arg Asp Ser Ser Asp Ile Ser Arg Ser Cys Tyr 
545                 550                 555                 560 


Asn Asp Leu Pro Ser Asn Val Tyr Val Cys Ser Gly Pro Asp Cys Gly 
                565                 570                 575     


Leu Gly Asn Asp Asn Ala Val Lys Gln Ala Glu Thr Leu Phe Gln Glu 
            580                 585                 590         


Ile Cys Pro Asn Glu Asp Phe Cys Pro Pro Pro Pro Asn Pro Glu Asp 
        595                 600                 605             


Ile Ile Leu Asp Gly Asp Ser Leu Gln Pro Glu Ala Ser Glu Ser Ser 
    610                 615                 620                 


Ala Ile Pro Glu Ala Asn Ser Glu Thr Phe Lys Glu Ser Thr Asn Leu 
625                 630                 635                 640 


Gly Asn Leu Glu Glu Ser Ser Glu 
                645             


<210> 2
<211> 653
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Met Ala Asp Thr Leu Pro Ser Glu Phe Asp Val Ile Val Ile Gly Thr 
1               5                   10                  15      


Gly Leu Pro Glu Ser Ile Ile Ala Ala Ala Cys Ser Arg Ser Gly Arg 
            20                  25                  30          


Arg Val Leu His Val Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala 
        35                  40                  45              


Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Glu 
    50                  55                  60                  


Asn Ser Asp Ile Val Ser Asp Ser Pro Val Trp Gln Asp Gln Ile Leu 
65                  70                  75                  80  


Glu Asn Glu Glu Ala Ile Ala Leu Ser Arg Lys Asp Lys Thr Ile Gln 
                85                  90                  95      


His Val Glu Val Phe Cys Tyr Ala Ser Gln Asp Leu His Glu Asp Val 
            100                 105                 110         


Glu Glu Ala Gly Ala Leu Gln Lys Asn His Ala Leu Val Thr Ser Ala 
        115                 120                 125             


Asn Ser Thr Glu Ala Ala Asp Ser Ala Phe Leu Pro Thr Glu Asp Glu 
    130                 135                 140                 


Ser Leu Ser Thr Met Ser Cys Glu Met Leu Thr Glu Gln Thr Pro Ser 
145                 150                 155                 160 


Ser Asp Pro Glu Asn Ala Leu Glu Val Asn Gly Ala Glu Val Thr Gly 
                165                 170                 175     


Glu Lys Glu Asn His Cys Asp Asp Lys Thr Cys Val Pro Ser Thr Ser 
            180                 185                 190         


Ala Glu Asp Met Ser Glu Asn Val Pro Ile Ala Glu Asp Thr Thr Glu 
        195                 200                 205             


Gln Pro Lys Lys Asn Arg Ile Thr Tyr Ser Gln Ile Ile Lys Glu Gly 
    210                 215                 220                 


Arg Arg Phe Asn Ile Asp Leu Val Ser Lys Leu Leu Tyr Ser Arg Gly 
225                 230                 235                 240 


Leu Leu Ile Asp Leu Leu Ile Lys Ser Asn Val Ser Arg Tyr Ala Glu 
                245                 250                 255     


Phe Lys Asn Ile Thr Arg Ile Leu Ala Phe Arg Glu Gly Arg Val Glu 
            260                 265                 270         


Gln Val Pro Cys Ser Arg Ala Asp Val Phe Asn Ser Lys Gln Leu Thr 
        275                 280                 285             


Met Val Glu Lys Arg Met Leu Met Lys Phe Leu Thr Phe Cys Met Glu 
    290                 295                 300                 


Tyr Glu Lys Tyr Pro Asp Glu Tyr Lys Gly Tyr Glu Glu Ile Thr Phe 
305                 310                 315                 320 


Tyr Glu Tyr Leu Lys Thr Gln Lys Leu Thr Pro Asn Leu Gln Tyr Ile 
                325                 330                 335     


Val Met His Ser Ile Ala Met Thr Ser Glu Thr Ala Ser Ser Thr Ile 
            340                 345                 350         


Asp Gly Leu Lys Ala Thr Lys Asn Phe Leu His Cys Leu Gly Arg Tyr 
        355                 360                 365             


Gly Asn Thr Pro Phe Leu Phe Pro Leu Tyr Gly Gln Gly Glu Leu Pro 
    370                 375                 380                 


Gln Cys Phe Cys Arg Met Cys Ala Val Phe Gly Gly Ile Tyr Cys Leu 
385                 390                 395                 400 


Arg His Ser Val Gln Cys Leu Val Val Asp Lys Glu Ser Arg Lys Cys 
                405                 410                 415     


Lys Ala Ile Ile Asp Gln Phe Gly Gln Arg Ile Ile Ser Glu His Phe 
            420                 425                 430         


Leu Val Glu Asp Ser Tyr Phe Pro Glu Asn Met Cys Ser Arg Val Gln 
        435                 440                 445             


Tyr Arg Gln Ile Ser Arg Ala Val Leu Ile Thr Asp Arg Ser Val Leu 
    450                 455                 460                 


Lys Thr Asp Ser Asp Gln Gln Ile Ser Ile Leu Thr Val Pro Ala Glu 
465                 470                 475                 480 


Glu Pro Gly Thr Phe Ala Val Arg Val Ile Glu Leu Cys Ser Ser Thr 
                485                 490                 495     


Met Thr Cys Met Lys Gly Thr Tyr Leu Val His Leu Thr Cys Thr Ser 
            500                 505                 510         


Ser Lys Thr Ala Arg Glu Asp Leu Glu Ser Val Val Gln Lys Leu Phe 
        515                 520                 525             


Val Pro Tyr Thr Glu Met Glu Ile Glu Asn Glu Gln Val Glu Lys Pro 
    530                 535                 540                 


Arg Ile Leu Trp Ala Leu Tyr Phe Asn Met Arg Asp Ser Ser Asp Ile 
545                 550                 555                 560 


Ser Arg Ser Cys Tyr Asn Asp Leu Pro Ser Asn Val Tyr Val Cys Ser 
                565                 570                 575     


Gly Pro Asp Cys Gly Leu Gly Asn Asp Asn Ala Val Lys Gln Ala Glu 
            580                 585                 590         


Thr Leu Phe Gln Glu Ile Cys Pro Asn Glu Asp Phe Cys Pro Pro Pro 
        595                 600                 605             


Pro Asn Pro Glu Asp Ile Ile Leu Asp Gly Asp Ser Leu Gln Pro Glu 
    610                 615                 620                 


Ala Ser Glu Ser Ser Ala Ile Pro Glu Ala Asn Ser Glu Thr Phe Lys 
625                 630                 635                 640 


Glu Ser Thr Asn Leu Gly Asn Leu Glu Glu Ser Ser Glu 
                645                 650             


<210> 3
<211> 1947
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 3
atggcggata ctctcccttc ggagtttgat gtgatcgtaa tagggacggg tttgcctgaa       60

tccatcattg cagctgcatg ttcaagaagt ggccggagag ttctgcatgt tgattcaaga      120

agctactatg gaggaaactg ggccagtttt agcttttcag gactattgtc ctggctaaag      180

gaataccagg aaaacagtga cattgtaagt gacagtccag tgtggcaagc cgatccttga      240

aaatgaagag ccattgctct tagcaggaag gacaaaacat tcaacatgtg gaagtatttt      300

gttatgccag tcaggatttg catgaagatg tcgaagaagc tggtgcactg cagaaaaatc      360

atgctcttgt gacatctgca aactccacag aagctgcaga ttctgccttc ctgcctacgg      420

aggatgagtc attaagcact atgagctgtg aaatgctcac agaacaaact ccaagcagcg      480

atccagagaa tgcgctagaa gtaaatggtg ctgaagtgac aggggaaaaa gaaaaccatt      540

gtgatgataa aacttgtgtg ccatcaactt cagcagaaga catgagtgaa aatgtgccta      600

tagcagaaga taccacagag caaccaaaga aaaacagaat tacttactca caaattatta      660

aagaaggcag gagatttaat attgatttag tatcaaagct gctgtattct cgaggattac      720

taattgatct tctaatcaaa tctaatgtta gtcgatatgc agagtttaaa aatattacca      780

ggattcttgc atttcgagaa ggcgagtgga acaggttccg tgttccggcg atgtctttaa      840

tagcaaacaa cttactatgg tagaaaagcg aatgctaatg aaatttctta cattttgtat      900

ggaatatgag aaatatcctg atgaatataa aggatatgaa gagatcacat ttttgaattt      960

taaagactca aaaattaacc cccaacctcc aatatattgt catgcattca attgcaatga     1020

catcagagac agccagcagc accatagatg gtctcaaagc taccaaaaac tttcttcact     1080

gtcttgggcg gtatggcaac actccatttt tgtttccttt atatggccaa ggagaactcc     1140

cccagtgttt ctgcaggatg tgtgctgtgt ttggtggaat ttattgtctt cgccattcag     1200

tacagtgcct tgtagtggac aaagaatcca gaaaatgtaa agcaattata gatcagtttg     1260

gtcagagaat aatctctgag catttcctcg tggaggacag ttactttcct gagaacatgt     1320

gctcacgtgt gcaatacagg cagatctcca gggcagtgct gattacagaa gatctgtcct     1380

aaaaacagat tcagatcaac gatttccttt tgacagtgcc agcagaggaa ccaggaactt     1440

ttgctgttcg ggtcattgag ttatgttctt caacgatgac atgcatgaaa ggcacctatt     1500

tggttcattt gacttgcaca tcttctaaaa cagcaagaga agatttagaa tcagttgtgc     1560

agaaattgtt tgttccatat actgaaatgg agatagaaaa tgaacaagta gaaaagccaa     1620

gaattctgtg ggctctttac ttcaatatga gagattcgtc agacatcagc aggagctgtt     1680

ataatgattt accatccaac gtttatgtct gctctggccc agattgtggt ttaggaaatg     1740

ataatgcagt caaacaggct gaaacacttt tccaggaaat ctgccccaat gaagatttct     1800

gtccccctcc ccaaatcctg aagacattat ccttgatgga gacagtttac agccagaggc     1860

ttcagaatcc agtgccatac cagaggctaa ctcggagact ttcaaggaaa gcacaaacct     1920

tggaaaccta gaggagtcct ctgaaaa                                         1947


<210> 4
<211> 1985
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 4
gatatcgaat tcctgcagcc cggcggcacc atggcggata ctctcccttc ggagtttgat       60

gtgatcgtaa tagggacggg tttgcctgaa tccatcattg cagctgcatg ttcaagaagt      120

ggccggagag ttctgcatgt tgattcaaga agctactatg gaggaaactg ggccagtttt      180

agcttttcag gactattgtc ctggctaaag gaataccagg aaaacagtga cattgtaagt      240

gacagtccag tgtggcaaga ccagatcctt gaaaatgaag aagccattgc tcttagcagg      300

aaggacaaaa ctattcaaca tgtggaagta ttttgttatg ccagtcagga tttgcatgaa      360

gatgtcgaag aagctggtgc actgcagaaa aatcatgctc ttgtgacatc tgcaaactcc      420

acagaagctg cagattctgc cttcctgcct acggaggatg agtcattaag cactatgagc      480

tgtgaaatgc tcacagaaca aactccaagc agcgatccag agaatgcgct agaagtaaat      540

ggtgctgaag tgacagggga aaaagaaaac cattgtgatg ataaaacttg tgtgccatca      600

acttcagcag aagacatgag tgaaaatgtg cctatagcag aagataccac agagcaacca      660

aagaaaaacg aattacttac tcacaaatat taagaaggca ggagattaat attgatttag      720

tatcaaagct gctgtattct cgaggattac taattgatct tctaatcaaa tctaatgtta      780

gtcgatatgc agagtttaaa aatattacca ggattcttgc atttcgagaa ggacgagtgg      840

aacaggttcc gtgttccaga gcagatgtct ttaatagcaa acaacttact atggtagaaa      900

agcgaatgct aatgaaattt cttacatttt gtatggaata tgagaaatat cctgatgaat      960

ataaaggata tgaagagatc acattttatg aatatttaaa gactcaaaaa ttaaccccca     1020

acctccaata tattgtcatg cattcaattg caatgacatc agagacagcc agcagcacca     1080

tagatggtct caaagctacc aaaaactttc ttcactgtct tgggcggtat ggcaacactc     1140

catttttgtt tcctttatat ggccaaggag aactccccca gtgtttctgc aggatgtgtg     1200

ctgtgtttgg tggaatttat tgtcttcgcc attcagtaca gtgccttgta gtggacaaag     1260

aatccagaaa atgtaaagca attatagatc agtttggtca gagaataatc tctgagcatt     1320

tcctcgtgga ggacagttac tttcctgaga acatgtgctc acgtgtgcaa tacaggcaga     1380

tctccagggc agtgctgatt acagatagat ctgtcctaaa aacagattca gatcaacaga     1440

tttccatttt gacagtgcca gcagaggaac caggaacttt tgctgttcgg gtcattgagt     1500

tatgttcttc aacgatgaca tgctgaaagg cacctatttg gttcatttga cttgcacatc     1560

ttctaaaaca gcaagagaag atttagaatc agttgtgcag aaattgtttg ttccatatac     1620

tgaaatggag atagaaaatg aacaagtaga aaagccaaga attctgtggg ctctttactt     1680

caatatgaga gattcgtcag acatcagcag gagctgttat aatgatttac catccaacgt     1740

ttatgtctgc tctggcccag attgtggttt aggaaatgat aatgcagtca aacaggctga     1800

aacacttttc caggaaatct gccccaatga agatttctgt ccccctccac caaatcctga     1860

agacattatc cttgatggag acagtttaca gccagaggct tcagaatcca gtgccatacc     1920

agaggctaac tcggagactt tcaggaaagc acaaaccttg gaaacctaga ggagtcctct     1980

gaaaa                                                                 1985


<210> 5
<211> 1962
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 5
atggcggata ctctcccttc ggagtttgat gtgatcgtaa tagggacggg tttgcctgaa       60

tccatcattg cagctgcatg ttcaagaagt ggccggagag ttctgcatgt tgattcaaga      120

agctactatg gaggaaactg ggccagtttt agcttttcag gactattgtc ctggctaaag      180

gaataccagg aaaacagtga cattgtaagt gacagtccag tgtggcaaga ccagatcctt      240

gaaaatgaag aagccattgc tcttagcagg aaggacaaaa ctattcaaca tgtggaagta      300

ttttgttatg ccagtcagga tttgcatgaa gatgtcgaag aagctggtgc actgcagaaa      360

aatcatgctc ttgtgacatc tgcaaactcc acagaagctg cagattctgc cttcctgcct      420

acggaggatg agtcattaag cactatgagc tgtgaaatgc tcacagaaca aactccaagc      480

agcgatccag agaatgcgct agaagtaaat ggtgctgaag tgacagggga aaaagaaaac      540

cattgtgatg ataaaacttg tgtgccatca acttcagcag aagacatgag tgaaaatgtg      600

cctatagcag aagataccac agagcaacca aagaaaaaca gaattactta ctcacaaatt      660

attaaagaag gcaggagatt taatattgat ttagtatcaa agctgctgta ttctcgagga      720

ttactaattg atcttctaat caaatctaat gttagtcgat atgcagagtt taaaaatatt      780

accaggattc ttgcatttcg agaaggacga gtggaacagg ttccgtgttc cagagcagat      840

gtctttaata gcaaacaact tactatggta gaaaagcgaa tgctaatgaa atttcttaca      900

ttttgtatgg aatatgagaa atatcctgat gaatataaag gatatgaaga gatcacattt      960

tatgaatatt taaagactca aaaattaacc cccaacctcc aatatattgt catgcattca     1020

attgcaatga catcagagac agccagcagc accatagatg gtctcaaagc taccaaaaac     1080

tttcttcact gtcttgggcg gtatggcaac actccatttt tgtttccttt atatggccaa     1140

ggagaactcc cccagtgttt ctgcaggatg tgtgctgtgt ttggtggaat ttattgtctt     1200

cgccattcag tacagtgcct tgtagtggac aaagaatcca gaaaatgtaa agcaattata     1260

gatcagtttg gtcagagaat aatctctgag catttcctcg tggaggacag ttactttcct     1320

gagaacatgt gctcacgtgt gcaatacagg cagatctcca gggcagtgct gattacagat     1380

agatctgtcc taaaaacaga ttcagatcaa cagatttcca ttttgacagt gccagcagag     1440

gaaccaggaa cttttgctgt tcgggtcatt gagttatgtt cttcaacgat gacatgcatg     1500

aaaggcacct atttggttca tttgacttgc acatcttcta aaacagcaag agaagattta     1560

gaatcagttg tgcagaaatt gtttgttcca tatactgaaa tggagataga aaatgaacaa     1620

gtagaaaagc caagaattct gtgggctctt tacttcaata tgagagattc gtcagacatc     1680

agcaggagct gttataatga tttaccatcc aacgtttatg tctgctctgg cccagattgt     1740

ggtttaggaa atgataatgc agtcaaacag gctgaaacac ttttccagga aatctgcccc     1800

aatgaagatt tctgtccccc tccaccaaat cctgaagaca ttatccttga tggagacagt     1860

ttacagccag aggcttcaga atccagtgcc ataccagagg ctaactcgga gactttcaag     1920

gaaagcacaa accttggaaa cctagaggag tcctctgaat aa                        1962


<210> 6
<211> 1992
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 6
gatatcgaat tcctgcagcc cggcggcacc atggcggata ctctcccttc ggagtttgat       60

gtgatcgtaa tagggacggg tttgcctgaa tccatcattg cagctgcatg ttcaagaagt      120

ggccggagag ttctgcatgt tgattcaaga agctactatg gaggaaactg ggccagtttt      180

agcttttcag gactattgtc ctggctaaag gaataccagg aaaacagtga cattgtaagt      240

gacagtccag tgtggcaaga ccagatcctt gaaaatgaag aagccattgc tcttagcagg      300

aaggacaaaa ctattcaaca tgtggaagta ttttgttatg ccagtcagga tttgcatgaa      360

gatgtcgaag aagctggtgc actgcagaaa aatcatgctc ttgtgacatc tgcaaactcc      420

acagaagctg cagattctgc cttcctgcct acggaggatg agtcattaag cactatgagc      480

tgtgaaatgc tcacagaaca aactccaagc agcgatccag agaatgcgct agaagtaaat      540

ggtgctgaag tgacagggga aaaagaaaac cattgtgatg ataaaacttg tgtgccatca      600

acttcagcag aagacatgag tgaaaatgtg cctatagcag aagataccac agagcaacca      660

aagaaaaaca gaattactta ctcacaaatt attaaagaag gcaggagatt taatattgat      720

ttagtatcaa agctgctgta ttctcgagga ttactaattg atcttctaat caaatctaat      780

gttagtcgat atgcagagtt taaaaatatt accaggattc ttgcatttcg agaaggacga      840

gtggaacagg ttccgtgttc cagagcagat gtctttaata gcaaacaact tactatggta      900

gaaaagcgaa tgctaatgaa atttcttaca ttttgtatgg aatatgagaa atatcctgat      960

gaatataaag gatatgaaga gatcacattt tatgaatatt taaagactca aaaattaacc     1020

cccaacctcc aatatattgt catgcattca attgcaatga catcagagac agccagcagc     1080

accatagatg gtctcaaagc taccaaaaac tttcttcact gtcttgggcg gtatggcaac     1140

actccatttt tgtttccttt atatggccaa ggagaactcc cccagtgttt ctgcaggatg     1200

tgtgctgtgt ttggtggaat ttattgtctt cgccattcag tacagtgcct tgtagtggac     1260

aaagaatcca gaaaatgtaa agcaattata gatcagtttg gtcagagaat aatctctgag     1320

catttcctcg tggaggacag ttactttcct gagaacatgt gctcacgtgt gcaatacagg     1380

cagatctcca gggcagtgct gattacagat agatctgtcc taaaaacaga ttcagatcaa     1440

cagatttcca ttttgacagt gccagcagag gaaccaggaa cttttgctgt tcgggtcatt     1500

gagttatgtt cttcaacgat gacatgcatg aaaggcacct atttggttca tttgacttgc     1560

acatcttcta aaacagcaag agaagattta gaatcagttg tgcagaaatt gtttgttcca     1620

tatactgaaa tggagataga aaatgaacaa gtagaaaagc caagaattct gtgggctctt     1680

tacttcaata tgagagattc gtcagacatc agcaggagct gttataatga tttaccatcc     1740

aacgtttatg tctgctctgg cccagattgt ggtttaggaa atgataatgc agtcaaacag     1800

gctgaaacac ttttccagga aatctgcccc aatgaagatt tctgtccccc tccaccaaat     1860

cctgaagaca ttatccttga tggagacagt ttacagccag aggcttcaga atccagtgcc     1920

ataccagagg ctaactcgga gactttcaag gaaagcacaa accttggaaa cctagaggag     1980

tcctctgaat aa                                                         1992


<210> 7
<211> 208
<212> PRT
<213> Homo sapiens

<400> 7
Met Ser Thr Gly Gly Asp Phe Gly Asn Pro Leu Arg Lys Phe Lys Leu 
1               5                   10                  15      


Val Phe Leu Gly Glu Gln Ser Val Gly Lys Thr Ser Leu Ile Thr Arg 
            20                  25                  30          


Phe Met Tyr Asp Ser Phe Asp Asn Thr Tyr Gln Ala Thr Ile Gly Ile 
        35                  40                  45              


Asp Phe Leu Ser Lys Thr Met Tyr Leu Glu Asp Arg Thr Val Arg Leu 
    50                  55                  60                  


Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser Leu Ile Pro 
65                  70                  75                  80  


Ser Tyr Ile Arg Asp Ser Thr Val Ala Val Val Val Tyr Asp Ile Thr 
                85                  90                  95      


Asn Val Asn Ser Phe Gln Gln Thr Thr Lys Trp Ile Asp Asp Val Arg 
            100                 105                 110         


Thr Glu Arg Gly Ser Asp Val Ile Ile Met Leu Val Gly Asn Lys Thr 
        115                 120                 125             


Asp Leu Ala Asp Lys Arg Gln Val Ser Ile Glu Glu Gly Glu Arg Lys 
    130                 135                 140                 


Ala Lys Glu Leu Asn Val Met Phe Ile Glu Thr Ser Ala Lys Ala Gly 
145                 150                 155                 160 


Tyr Asn Val Lys Gln Leu Phe Arg Arg Val Ala Ala Ala Leu Pro Gly 
                165                 170                 175     


Met Glu Ser Thr Gln Asp Arg Ser Arg Glu Asp Met Ile Asp Ile Lys 
            180                 185                 190         


Leu Glu Lys Pro Gln Glu Gln Pro Val Ser Glu Gly Gly Cys Ser Cys 
        195                 200                 205             


<210> 8
<211> 208
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Met Ser Thr Gly Gly Asp Phe Gly Asn Pro Leu Arg Lys Phe Lys Leu 
1               5                   10                  15      


Val Phe Leu Gly Glu Gln Ser Val Gly Lys Thr Ser Leu Ile Thr Arg 
            20                  25                  30          


Phe Met Tyr Asp Ser Phe Asp Asn Thr Tyr Gln Ala Thr Ile Gly Ile 
        35                  40                  45              


Asp Phe Leu Ser Lys Thr Met Tyr Leu Glu Asp Arg Thr Val Arg Leu 
    50                  55                  60                  


Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser Leu Ile Pro 
65                  70                  75                  80  


Ser Tyr Ile Arg Asp Ser Thr Val Ala Val Val Val Tyr Asp Ile Thr 
                85                  90                  95      


Asn Val Asn Ser Phe Gln Gln Thr Thr Lys Trp Ile Asp Asp Val Arg 
            100                 105                 110         


Thr Glu Arg Gly Ser Asp Val Ile Ile Met Leu Val Gly Asn Lys Thr 
        115                 120                 125             


Asp Leu Ala Asp Lys Arg Gln Val Ser Ile Glu Glu Gly Glu Arg Lys 
    130                 135                 140                 


Ala Lys Glu Leu Asn Val Met Phe Ile Glu Thr Ser Ala Lys Ala Gly 
145                 150                 155                 160 


Tyr Asn Val Lys Gln Leu Phe Arg Arg Val Ala Ala Ala Leu Pro Gly 
                165                 170                 175     


Met Glu Ser Thr Gln Asp Arg Ser Arg Glu Asp Met Ile Asp Ile Lys 
            180                 185                 190         


Leu Glu Lys Pro Gln Glu Gln Pro Val Ser Glu Gly Gly Cys Ser Cys 
        195                 200                 205             


<210> 9
<211> 3419
<212> DNA
<213> Homo sapiens

<400> 9
gcacgcacgc acgcacgcca gcggccggcg gggccgcagg ctcgcgcccg ggctcgcccc       60

gcgccgctcc agaggctcgc gcactcagca ggttgggctg cggcggcggc ggcagctgtg      120

gaagctcagg cgctgcgcgt gagaggtccc agatacgtct gcggttccgg ctccgccacc      180

ctcagcttct cttccccagg tctgggagcc gagtgcggaa ggagggaacg gccctagctt      240

tgggaagcca gaggacaccc ctggctcctg ccgacaccgc cctccttccc ttcccagccg      300

cgggcctcgc tcggtgctag gctactctgc cgggaggcgg cggcggctgc cagtctgtgg      360

agagtcctgc tgccctccag ccgggctcct ccaccgggcc ttgcaggggc cgagagagct      420

cggtgcccgc ccttccgctc gcctttttcg tcagctggct ggagcagcat cggtccggga      480

ggtctctagg ctgaggcggc ggccgctcct ctagttccac aatgtccacg ggcggagact      540

tcgggaatcc gctgaggaaa ttcaagctgg tgttcctggg ggagcaaagc gttggaaaga      600

catctttgat caccagattc atgtatgaca gttttgacaa cacctatcag gcaacaattg      660

gcattgactt tttatcaaaa actatgtact tggaggatcg aacagtacga ttgcaattat      720

gggacacagc aggtcaagag cggttcagga gcttgattcc tagctacatt cgtgactcca      780

ctgtggcagt tgttgtttat gatatcacaa atgttaactc attccagcaa actacaaagt      840

ggattgatga tgtcagaaca gaaagaggaa gtgatgttat catcatgcta gtaggaaata      900

aaacagatct tgctgacaag aggcaagtgt caattgagga gggagagagg aaagccaaag      960

agctgaatgt tatgtttatt gaaactagtg caaaagctgg atacaatgta aagcagctct     1020

ttcgacgtgt agcagcagct ttgccgggaa tggaaagcac acaggacaga agcagagaag     1080

atatgattga cataaaactg gaaaagcctc aggagcaacc agtcagtgaa ggaggctgtt     1140

cctgctaatc tcccatgtca tcttcaacct tcttcagaag ctcactgctt tggccccctt     1200

actctttcat tgactgcagt gtgaatattg gcttgaacct tttcccttca gtaataacgt     1260

attgcaattc atcattgctg cctgtctcgt ggagatgatc tattagcttc acaagcacaa     1320

caaaagtcag tgtcttcatt atttatattt tacaaaaagc caaaatattt cagcatattc     1380

cagtgataac tttaaaaatt agatacattt tcttaacatt tttttctttt ttaatgttat     1440

gataatgtac ttcaaaatga tggaaatctc aacagtatga gtatggcttg gttaacgagc     1500

ggtatgttca cagcctactt tatctctcct tgcttttctc acctctcact tacccccatt     1560

ccctattacc ctattcttac ctagcctccc ccgacttcct caaaacaaac aagagatggc     1620

aaagcagcag ttctaccaag cccattggaa ttatccttta attttacaga taccacttgc     1680

tgtaggctac ggaccaagat gtccaaaatt attcttgagc actgatataa attacggtct     1740

tctttgaggt caaaattcag ccatcatggt aggcagtgct tgaatgagaa aaggctcctg     1800

gtgcatcttc aaaatgagtc ctaaagaaca tactgagtac ttagaagtag aagaacataa     1860

gatgtatttc tgactaaaac aaatggctct ttcacatgtg ctttattaga ctctgggaga     1920

gaaaattaac caagtgcttc agaacaggtt tttagtattt aattcttcac ggtaagaaaa     1980

tgaagttcta atgaactgtt tctcccaagg ttttaaaatt gtcaagagtt attctgtttg     2040

tttaaaaaat aagaaacctc tttaagcaat agattttgct tgggttttct tttttaaaaa     2100

cataatactg tgcaggcaag gcactgtaaa agttttaatt ccttccagaa gaaccagtgg     2160

aagaatttaa atttggcgct acgatcaaaa ctactgaatt agtagaaata atgatgtcta     2220

aagcttacca acaaaagaac cctcagcaga ataacaaaaa ctttgctcag gacatttgag     2280

gtcaaattga agacggaaac cggaaaccgt tttcttgtaa gcccctagag gcagatcagg     2340

taaagcatac atagtagagg gaaaggagag aatggaaata aaactcaata ttatgcagat     2400

ttatgcctta ttttttagca ttttttaagg ttgggtcttt caggctggtt ttggtttgta     2460

ttagatctgt atagtttaat taactggtga tttagtttta tatttaagct acaattaatc     2520

ttttttcttt ggtgatattt atttctttgc cttttttttt tttaacaact ttcaatcttc     2580

agatgtttcg ttgaatctat ttagagcttc accatggcaa tatgtatttc ccttaaaaca     2640

ctgcaaacaa atatactagg agtgtgccct tttaatcttt actagttatt gtgagattgc     2700

tgtgtaagct aataaacaca tttgtaaata cattgtttgc aggacgaaaa cttctgagtt     2760

acagctcagg aaaagcctgc tgaatttatg ttgtaagcat tacttaacac agtataaaga     2820

tgaaaagaca acaaaaatat cttcatactt cctcatcccc tcattggaac aaaaccttaa     2880

actgggagaa ccttagtccc ctctctttcc tcttcctcct ccacttccca cttattgtca     2940

ccttgtaata ttcagagagc acttggatta tggatctgaa tagagaaatg cttacagata     3000

atcattagcc cacataccag taacttatac ttaaagatgg gatggagttg taaagtgctt     3060

ttataataca atataattgt taaaggcaag ggttgactct ttgttttatt ttgacatggc     3120

atgtcctgaa ataaatattg attcaatatg gcagatgggt catattcttt atttggaaga     3180

agttgtgact tctgacatgg gtgtgattgt cttcctacac tgttgcattt gattcttttt     3240

atgtattttt aagaaagtaa ccagttatac tgcttttaat attgattggt ctttttattt     3300

ggcttggagt tcttcaaagc attgaagtgt gttcatagtc caggtttttt ttttaataaa     3360

cacaattttg ctgccaaaaa tatataaata aaacacgaaa gaaaacaaaa aaaaaaaaa      3419


<210> 10
<211> 627
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 10
atgtccacgg gcggagactt cgggaatccg ctgaggaaat tcaagctggt gttcctgggg       60

gagcaaagcg ttggaaagac atctttgatc accagattca tgtatgacag ttttgacaac      120

acctatcagg caacaattgg cattgacttt ttatcaaaaa ctatgtactt ggaggatcga      180

acagtacgat tgcaattatg ggacacagca ggtcaagagc ggttcaggag cttgattcct      240

agctacattc gtgactccac tgtggcagtt gttgtttatg atatcacaaa tgttaactca      300

ttccagcaaa ctacaaagtg gattgatgat gtcagaacag aaagaggaag tgatgttatc      360

atcatgctag taggaaataa aacagatctt gctgacaaga ggcaagtgtc aattgaggag      420

ggagagagga aagccaaaga gctgaatgtt atgtttattg aaactagtgc aaaagctgga      480

tacaatgtaa agcagctctt tcgacgtgta gcagcagctt tgccgggaat ggaaagcaca      540

caggacagaa gcagagaaga tatgattgac ataaaactgg aaaagcctca ggagcaacca      600

gtcagtgaag gaggctgttc ctgctaa                                          627


<210> 11
<211> 3419
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 11
gcacgcacgc acgcacgcca gcggccggcg gggccgcagg ctcgcgcccg ggctcgcccc       60

gcgccgctcc agaggctcgc gcactcagca ggttgggctg cggcggcggc ggcagctgtg      120

gaagctcagg cgctgcgcgt gagaggtccc agatacgtct gcggttccgg ctccgccacc      180

ctcagcttct cttccccagg tctgggagcc gagtgcggaa ggagggaacg gccctagctt      240

tgggaagcca gaggacaccc ctggctcctg ccgacaccgc cctccttccc ttcccagccg      300

cgggcctcgc tcggtgctag gctactctgc cgggaggcgg cggcggctgc cagtctgtgg      360

agagtcctgc tgccctccag ccgggctcct ccaccgggcc ttgcaggggc cgagagagct      420

cggtgcccgc ccttccgctc gcctttttcg tcagctggct ggagcagcat cggtccggga      480

ggtctctagg ctgaggcggc ggccgctcct ctagttccac aatgtccacg ggcggagact      540

tcgggaatcc gctgaggaaa ttcaagctgg tgttcctggg ggagcaaagc gttggaaaga      600

catctttgat caccagattc atgtatgaca gttttgacaa cacctatcag gcaacaattg      660

gcattgactt tttatcaaaa actatgtact tggaggatcg aacagtacga ttgcaattat      720

gggacacagc aggtcaagag cggttcagga gcttgattcc tagctacatt cgtgactcca      780

ctgtggcagt tgttgtttat gatatcacaa atgttaactc attccagcaa actacaaagt      840

ggattgatga tgtcagaaca gaaagaggaa gtgatgttat catcatgcta gtaggaaata      900

aaacagatct tgctgacaag aggcaagtgt caattgagga gggagagagg aaagccaaag      960

agctgaatgt tatgtttatt gaaactagtg caaaagctgg atacaatgta aagcagctct     1020

ttcgacgtgt agcagcagct ttgccgggaa tggaaagcac acaggacaga agcagagaag     1080

atatgattga cataaaactg gaaaagcctc aggagcaacc agtcagtgaa ggaggctgtt     1140

cctgctaatc tcccatgtca tcttcaacct tcttcagaag ctcactgctt tggccccctt     1200

actctttcat tgactgcagt gtgaatattg gcttgaacct tttcccttca gtaataacgt     1260

attgcaattc atcattgctg cctgtctcgt ggagatgatc tattagcttc acaagcacaa     1320

caaaagtcag tgtcttcatt atttatattt tacaaaaagc caaaatattt cagcatattc     1380

cagtgataac tttaaaaatt agatacattt tcttaacatt tttttctttt ttaatgttat     1440

gataatgtac ttcaaaatga tggaaatctc aacagtatga gtatggcttg gttaacgagc     1500

ggtatgttca cagcctactt tatctctcct tgcttttctc acctctcact tacccccatt     1560

ccctattacc ctattcttac ctagcctccc ccgacttcct caaaacaaac aagagatggc     1620

aaagcagcag ttctaccaag cccattggaa ttatccttta attttacaga taccacttgc     1680

tgtaggctac ggaccaagat gtccaaaatt attcttgagc actgatataa attacggtct     1740

tctttgaggt caaaattcag ccatcatggt aggcagtgct tgaatgagaa aaggctcctg     1800

gtgcatcttc aaaatgagtc ctaaagaaca tactgagtac ttagaagtag aagaacataa     1860

gatgtatttc tgactaaaac aaatggctct ttcacatgtg ctttattaga ctctgggaga     1920

gaaaattaac caagtgcttc agaacaggtt tttagtattt aattcttcac ggtaagaaaa     1980

tgaagttcta atgaactgtt tctcccaagg ttttaaaatt gtcaagagtt attctgtttg     2040

tttaaaaaat aagaaacctc tttaagcaat agattttgct tgggttttct tttttaaaaa     2100

cataatactg tgcaggcaag gcactgtaaa agttttaatt ccttccagaa gaaccagtgg     2160

aagaatttaa atttggcgct acgatcaaaa ctactgaatt agtagaaata atgatgtcta     2220

aagcttacca acaaaagaac cctcagcaga ataacaaaaa ctttgctcag gacatttgag     2280

gtcaaattga agacggaaac cggaaaccgt tttcttgtaa gcccctagag gcagatcagg     2340

taaagcatac atagtagagg gaaaggagag aatggaaata aaactcaata ttatgcagat     2400

ttatgcctta ttttttagca ttttttaagg ttgggtcttt caggctggtt ttggtttgta     2460

ttagatctgt atagtttaat taactggtga tttagtttta tatttaagct acaattaatc     2520

ttttttcttt ggtgatattt atttctttgc cttttttttt tttaacaact ttcaatcttc     2580

agatgtttcg ttgaatctat ttagagcttc accatggcaa tatgtatttc ccttaaaaca     2640

ctgcaaacaa atatactagg agtgtgccct tttaatcttt actagttatt gtgagattgc     2700

tgtgtaagct aataaacaca tttgtaaata cattgtttgc aggacgaaaa cttctgagtt     2760

acagctcagg aaaagcctgc tgaatttatg ttgtaagcat tacttaacac agtataaaga     2820

tgaaaagaca acaaaaatat cttcatactt cctcatcccc tcattggaac aaaaccttaa     2880

actgggagaa ccttagtccc ctctctttcc tcttcctcct ccacttccca cttattgtca     2940

ccttgtaata ttcagagagc acttggatta tggatctgaa tagagaaatg cttacagata     3000

atcattagcc cacataccag taacttatac ttaaagatgg gatggagttg taaagtgctt     3060

ttataataca atataattgt taaaggcaag ggttgactct ttgttttatt ttgacatggc     3120

atgtcctgaa ataaatattg attcaatatg gcagatgggt catattcttt atttggaaga     3180

agttgtgact tctgacatgg gtgtgattgt cttcctacac tgttgcattt gattcttttt     3240

atgtattttt aagaaagtaa ccagttatac tgcttttaat attgattggt ctttttattt     3300

ggcttggagt tcttcaaagc attgaagtgt gttcatagtc caggtttttt ttttaataaa     3360

cacaattttg ctgccaaaaa tatataaata aaacacgaaa gaaaacaaaa aaaaaaaaa      3419


<210> 12
<211> 221
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Met Ser Asp Gly Asp Tyr Asp Tyr Leu Ile Lys Phe Leu Ala Leu Gly 
1               5                   10                  15      


Asp Ser Gly Val Gly Lys Thr Ser Val Leu Tyr Gln Tyr Thr Asp Gly 
            20                  25                  30          


Lys Phe Asn Ser Lys Phe Ile Thr Thr Val Gly Ile Asp Phe Arg Glu 
        35                  40                  45              


Lys Arg Val Val Tyr Arg Ala Ser Gly Pro Asp Gly Ala Thr Gly Arg 
    50                  55                  60                  


Gly Gln Arg Ile His Leu Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg 
65                  70                  75                  80  


Phe Arg Ser Leu Thr Thr Ala Phe Phe Arg Asp Ala Met Gly Phe Leu 
                85                  90                  95      


Leu Leu Phe Asp Leu Thr Asn Glu Gln Ser Phe Leu Asn Val Arg Asn 
            100                 105                 110         


Trp Ile Ser Gln Leu Gln Met His Ala Tyr Cys Glu Asn Pro Asp Ile 
        115                 120                 125             


Val Leu Cys Gly Asn Lys Ser Asp Leu Glu Asp Gln Arg Val Val Lys 
    130                 135                 140                 


Glu Glu Glu Ala Ile Ala Leu Ala Glu Lys Tyr Gly Ile Pro Tyr Phe 
145                 150                 155                 160 


Glu Thr Ser Ala Ala Asn Gly Thr Asn Ile Ser Gln Ala Ile Glu Met 
                165                 170                 175     


Leu Leu Asp Leu Ile Met Lys Arg Met Glu Arg Cys Val Asp Lys Ser 
            180                 185                 190         


Trp Ile Pro Glu Gly Val Val Arg Ser Asn Gly His Ala Ser Thr Asp 
        195                 200                 205             


Gln Leu Ser Glu Glu Lys Glu Lys Gly Ala Cys Gly Cys 
    210                 215                 220     


<210> 13
<211> 567
<212> PRT
<213> Homo sapiens

<400> 13
Met His Gly Arg Leu Lys Val Lys Thr Ser Glu Glu Gln Ala Glu Ala 
1               5                   10                  15      


Lys Arg Leu Glu Arg Glu Gln Lys Leu Lys Leu Tyr Gln Ser Ala Thr 
            20                  25                  30          


Gln Ala Val Phe Gln Lys Arg Gln Ala Gly Glu Leu Asp Glu Ser Val 
        35                  40                  45              


Leu Glu Leu Thr Ser Gln Ile Leu Gly Ala Asn Pro Asp Phe Ala Thr 
    50                  55                  60                  


Leu Trp Asn Cys Arg Arg Glu Val Leu Gln Gln Leu Glu Thr Gln Lys 
65                  70                  75                  80  


Ser Pro Glu Glu Leu Ala Ala Leu Val Lys Ala Glu Leu Gly Phe Leu 
                85                  90                  95      


Glu Ser Cys Leu Arg Val Asn Pro Lys Ser Tyr Gly Thr Trp His His 
            100                 105                 110         


Arg Cys Trp Leu Leu Gly Arg Leu Pro Glu Pro Asn Trp Thr Arg Glu 
        115                 120                 125             


Leu Glu Leu Cys Ala Arg Phe Leu Glu Val Asp Glu Arg Asn Phe His 
    130                 135                 140                 


Cys Trp Asp Tyr Arg Arg Phe Val Ala Thr Gln Ala Ala Val Pro Pro 
145                 150                 155                 160 


Ala Glu Glu Leu Ala Phe Thr Asp Ser Leu Ile Thr Arg Asn Phe Ser 
                165                 170                 175     


Asn Tyr Ser Ser Trp His Tyr Arg Ser Cys Leu Leu Pro Gln Leu His 
            180                 185                 190         


Pro Gln Pro Asp Ser Gly Pro Gln Gly Arg Leu Pro Glu Asp Val Leu 
        195                 200                 205             


Leu Lys Glu Leu Glu Leu Val Gln Asn Ala Phe Phe Thr Asp Pro Asn 
    210                 215                 220                 


Asp Gln Ser Ala Trp Phe Tyr His Arg Trp Leu Leu Gly Arg Ala Asp 
225                 230                 235                 240 


Pro Gln Asp Ala Leu Arg Cys Leu His Val Ser Arg Asp Glu Ala Cys 
                245                 250                 255     


Leu Thr Val Ser Phe Ser Arg Pro Leu Leu Val Gly Ser Arg Met Glu 
            260                 265                 270         


Ile Leu Leu Leu Met Val Asp Asp Ser Pro Leu Ile Val Glu Trp Arg 
        275                 280                 285             


Thr Pro Asp Gly Arg Asn Arg Pro Ser His Val Trp Leu Cys Asp Leu 
    290                 295                 300                 


Pro Ala Ala Ser Leu Asn Asp Gln Leu Pro Gln His Thr Phe Arg Val 
305                 310                 315                 320 


Ile Trp Thr Ala Gly Asp Val Gln Lys Glu Cys Val Leu Leu Lys Gly 
                325                 330                 335     


Arg Gln Glu Gly Trp Cys Arg Asp Ser Thr Thr Asp Glu Gln Leu Phe 
            340                 345                 350         


Arg Cys Glu Leu Ser Val Glu Lys Ser Thr Val Leu Gln Ser Glu Leu 
        355                 360                 365             


Glu Ser Cys Lys Glu Leu Gln Glu Leu Glu Pro Glu Asn Lys Trp Cys 
    370                 375                 380                 


Leu Leu Thr Ile Ile Leu Leu Met Arg Ala Leu Asp Pro Leu Leu Tyr 
385                 390                 395                 400 


Glu Lys Glu Thr Leu Gln Tyr Phe Gln Thr Leu Lys Ala Val Asp Pro 
                405                 410                 415     


Met Arg Ala Thr Tyr Leu Asp Asp Leu Arg Ser Lys Phe Leu Leu Glu 
            420                 425                 430         


Asn Ser Val Leu Lys Met Glu Tyr Ala Glu Val Arg Val Leu His Leu 
        435                 440                 445             


Ala His Lys Asp Leu Thr Val Leu Cys His Leu Glu Gln Leu Leu Leu 
    450                 455                 460                 


Val Thr His Leu Asp Leu Ser His Asn Arg Leu Arg Thr Leu Pro Pro 
465                 470                 475                 480 


Ala Leu Ala Ala Leu Arg Cys Leu Glu Val Leu Gln Ala Ser Asp Asn 
                485                 490                 495     


Ala Ile Glu Ser Leu Asp Gly Val Thr Asn Leu Pro Arg Leu Gln Glu 
            500                 505                 510         


Leu Leu Leu Cys Asn Asn Arg Leu Gln Gln Pro Ala Val Leu Gln Pro 
        515                 520                 525             


Leu Ala Ser Cys Pro Arg Leu Val Leu Leu Asn Leu Gln Gly Asn Pro 
    530                 535                 540                 


Leu Cys Gln Ala Val Gly Ile Leu Glu Gln Leu Ala Glu Leu Leu Pro 
545                 550                 555                 560 


Ser Val Ser Ser Val Leu Thr 
                565         


<210> 14
<211> 567
<212> PRT
<213> Rattus norvegicus

<400> 14
Met His Gly Arg Leu Lys Val Lys Thr Ser Glu Glu Gln Ala Glu Ala 
1               5                   10                  15      


Lys Arg Leu Glu Arg Glu Gln Lys Leu Lys Leu Tyr Gln Ser Ala Thr 
            20                  25                  30          


Gln Ala Val Phe Gln Lys Arg Gln Ala Gly Glu Leu Asp Glu Ser Val 
        35                  40                  45              


Leu Glu Leu Thr Ser Gln Ile Leu Gly Ala Asn Pro Asp Phe Ala Thr 
    50                  55                  60                  


Leu Trp Asn Cys Arg Arg Glu Val Leu Gln His Leu Glu Thr Glu Lys 
65                  70                  75                  80  


Ser Pro Glu Glu Ser Ala Ala Leu Val Lys Ala Glu Leu Gly Phe Leu 
                85                  90                  95      


Glu Ser Cys Leu Arg Val Asn Pro Lys Ser Tyr Gly Thr Trp His His 
            100                 105                 110         


Arg Cys Trp Leu Leu Ser Arg Leu Pro Glu Pro Asn Trp Ala Arg Glu 
        115                 120                 125             


Leu Glu Leu Cys Ala Arg Phe Leu Glu Ala Asp Glu Arg Asn Phe His 
    130                 135                 140                 


Cys Trp Asp Tyr Arg Arg Phe Val Ala Ala Gln Ala Ala Val Ala Pro 
145                 150                 155                 160 


Ala Glu Glu Leu Ala Phe Thr Asp Ser Leu Ile Thr Arg Asn Phe Ser 
                165                 170                 175     


Asn Tyr Ser Ser Trp His Tyr Arg Ser Cys Leu Leu Pro Gln Leu His 
            180                 185                 190         


Pro Gln Pro Asp Ser Gly Pro Gln Gly Arg Leu Pro Glu Asn Val Leu 
        195                 200                 205             


Leu Lys Glu Leu Glu Leu Val Gln Asn Ala Phe Phe Thr Asp Pro Asn 
    210                 215                 220                 


Asp Gln Ser Ala Trp Phe Tyr His Arg Trp Leu Leu Gly Arg Ala Glu 
225                 230                 235                 240 


Pro His Asp Val Leu Cys Cys Val His Val Ser Arg Glu Glu Ala Cys 
                245                 250                 255     


Leu Ser Val Cys Phe Ser Arg Pro Leu Thr Val Gly Ser Arg Met Gly 
            260                 265                 270         


Thr Leu Leu Leu Met Val Asp Glu Ala Pro Leu Ser Val Glu Trp Arg 
        275                 280                 285             


Thr Pro Asp Gly Arg Asn Arg Pro Ser His Val Trp Leu Cys Asp Leu 
    290                 295                 300                 


Pro Ala Ala Ser Leu Asn Asp Gln Leu Pro Gln His Thr Phe Arg Val 
305                 310                 315                 320 


Ile Trp Thr Gly Ser Asp Ser Gln Lys Glu Cys Val Leu Leu Lys Asp 
                325                 330                 335     


Arg Pro Glu Cys Trp Cys Arg Asp Ser Ala Thr Asp Glu Gln Leu Phe 
            340                 345                 350         


Arg Cys Glu Leu Ser Val Glu Lys Ser Thr Val Leu Gln Ser Glu Leu 
        355                 360                 365             


Glu Ser Cys Lys Glu Leu Gln Glu Leu Glu Pro Glu Asn Lys Trp Cys 
    370                 375                 380                 


Leu Leu Thr Ile Ile Leu Leu Met Arg Ala Leu Asp Pro Leu Leu Tyr 
385                 390                 395                 400 


Glu Lys Glu Thr Leu Gln Tyr Phe Ser Thr Leu Lys Ala Val Asp Pro 
                405                 410                 415     


Met Arg Ala Ala Tyr Leu Asp Asp Leu Arg Ser Lys Phe Leu Leu Glu 
            420                 425                 430         


Asn Ser Val Leu Lys Met Glu Tyr Ala Asp Val Arg Val Leu His Leu 
        435                 440                 445             


Ala His Lys Asp Leu Thr Val Leu Cys His Leu Glu Gln Leu Leu Leu 
    450                 455                 460                 


Val Thr His Leu Asp Leu Ser His Asn Arg Leu Arg Ala Leu Pro Pro 
465                 470                 475                 480 


Ala Leu Ala Ala Leu Arg Cys Leu Glu Val Leu Gln Ala Ser Asp Asn 
                485                 490                 495     


Ala Leu Glu Asn Val Asp Gly Val Ala Asn Leu Pro Arg Leu Gln Glu 
            500                 505                 510         


Leu Leu Leu Cys Asn Asn Arg Leu Gln Gln Ser Ala Ala Ile Gln Pro 
        515                 520                 525             


Leu Val Ser Cys Pro Arg Leu Val Leu Leu Asn Leu Gln Gly Asn Ser 
    530                 535                 540                 


Leu Cys Gln Glu Glu Gly Ile Gln Glu Arg Leu Ala Glu Met Leu Pro 
545                 550                 555                 560 


Ser Val Ser Ser Ile Leu Thr 
                565         


<210> 15
<211> 565
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Met His Gly Arg Leu Lys Val Lys Thr Ser Glu Glu Gln Ala Glu Ala 
1               5                   10                  15      


Lys Arg Leu Glu Arg Glu Gln Lys Leu Lys Leu Tyr Gln Ser Ala Thr 
            20                  25                  30          


Gln Ala Val Phe Gln Lys Arg Gln Ala Gly Glu Leu Asp Glu Ser Val 
        35                  40                  45              


Leu Glu Leu Thr Ser Gln Ile Leu Gly Ala Asn Pro Asp Phe Ala Thr 
    50                  55                  60                  


Leu Trp Asn Cys Arg Arg Glu Val Leu Gln Gln Leu Glu Thr Gln Lys 
65                  70                  75                  80  


Ser Pro Glu Glu Leu Ala Ala Leu Val Lys Ala Glu Leu Gly Phe Leu 
                85                  90                  95      


Glu Ser Cys Leu Arg Val Asn Pro Lys Ser Tyr Gly Thr Trp His His 
            100                 105                 110         


Arg Cys Leu Leu Gly Arg Leu Pro Glu Pro Asn Trp Thr Arg Glu Leu 
        115                 120                 125             


Glu Leu Cys Ala Arg Phe Leu Glu Val Asp Glu Arg Asn Phe His Cys 
    130                 135                 140                 


Trp Asp Tyr Arg Arg Phe Val Ala Thr Gln Ala Ala Val Pro Pro Ala 
145                 150                 155                 160 


Glu Glu Leu Ala Phe Thr Asp Ser Leu Ile Thr Arg Asn Phe Ser Asn 
                165                 170                 175     


Tyr Ser Ser Trp His Tyr Arg Ser Cys Leu Leu Pro Gln Leu His Pro 
            180                 185                 190         


Gln Pro Asp Ser Gly Pro Gln Gly Arg Leu Pro Glu Asp Val Leu Leu 
        195                 200                 205             


Lys Glu Leu Glu Leu Val Gln Asn Ala Phe Phe Thr Asp Pro Asn Asp 
    210                 215                 220                 


Gln Ser Ala Trp Phe Tyr His Arg Trp Leu Leu Gly Arg Ala Asp Pro 
225                 230                 235                 240 


Gln Asp Ala Leu Arg Cys Leu His Val Ser Arg Asp Glu Ala Cys Leu 
                245                 250                 255     


Thr Val Ser Phe Ser Arg Pro Leu Leu Val Gly Ser Arg Met Glu Ile 
            260                 265                 270         


Leu Leu Leu Met Val Asp Asp Ser Pro Leu Ile Val Glu Trp Arg Thr 
        275                 280                 285             


Pro Asp Gly Arg Asn Arg Pro Ser His Val Trp Leu Cys Asp Leu Pro 
    290                 295                 300                 


Ala Ala Ser Leu Asn Asp Gln Leu Pro Gln His Thr Phe Arg Val Ile 
305                 310                 315                 320 


Trp Thr Ala Gly Asp Val Gln Lys Glu Cys Val Leu Leu Lys Gly Arg 
                325                 330                 335     


Gln Glu Gly Trp Cys Arg Asp Ser Thr Thr Asp Glu Gln Leu Phe Arg 
            340                 345                 350         


Cys Glu Leu Ser Val Glu Lys Ser Thr Val Leu Gln Ser Glu Leu Glu 
        355                 360                 365             


Ser Cys Lys Glu Leu Gln Glu Leu Glu Pro Glu Asn Lys Trp Cys Leu 
    370                 375                 380                 


Leu Ile Ile Leu Leu Met Arg Ala Leu Asp Pro Leu Leu Tyr Glu Lys 
385                 390                 395                 400 


Glu Thr Leu Gln Tyr Phe Gln Thr Leu Lys Ala Val Asp Pro Met Arg 
                405                 410                 415     


Ala Thr Tyr Leu Asp Asp Leu Arg Ser Lys Phe Leu Leu Glu Asn Ser 
            420                 425                 430         


Val Leu Lys Met Glu Tyr Ala Glu Val Arg Val Leu His Leu Ala His 
        435                 440                 445             


Lys Asp Leu Thr Val Leu Cys His Leu Glu Gln Leu Leu Leu Val Thr 
    450                 455                 460                 


His Leu Asp Leu Ser His Asn Arg Leu Arg Thr Leu Pro Pro Ala Leu 
465                 470                 475                 480 


Ala Ala Leu Arg Cys Leu Glu Val Leu Gln Ala Ser Asp Asn Ala Ile 
                485                 490                 495     


Glu Ser Leu Asp Gly Val Thr Asn Leu Pro Arg Leu Gln Glu Leu Leu 
            500                 505                 510         


Leu Cys Asn Asn Arg Leu Gln Gln Pro Ala Val Leu Gln Pro Leu Ala 
        515                 520                 525             


Ser Cys Pro Arg Leu Val Leu Leu Asn Leu Gln Gly Asn Pro Leu Cys 
    530                 535                 540                 


Gln Ala Val Gly Ile Leu Glu Gln Leu Ala Glu Leu Leu Pro Ser Val 
545                 550                 555                 560 


Ser Ser Val Leu Thr 
                565 


<210> 16
<211> 563
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Met His Gly Arg Leu Lys Val Lys Thr Ser Glu Glu Gln Ala Glu Ala 
1               5                   10                  15      


Lys Arg Leu Glu Arg Glu Gln Lys Leu Lys Leu Tyr Gln Ser Ala Thr 
            20                  25                  30          


Gln Ala Val Phe Gln Lys Arg Gln Ala Gly Glu Leu Asp Glu Ser Val 
        35                  40                  45              


Leu Glu Leu Thr Ser Gln Ile Leu Gly Ala Asn Pro Asp Phe Ala Thr 
    50                  55                  60                  


Leu Trp Asn Cys Arg Arg Glu Val Leu Gln His Leu Glu Thr Glu Lys 
65                  70                  75                  80  


Ser Pro Glu Glu Ser Ala Ala Leu Val Lys Ala Glu Leu Gly Phe Leu 
                85                  90                  95      


Glu Ser Cys Leu Arg Val Asn Pro Lys Ser Tyr Gly Thr His His Arg 
            100                 105                 110         


Cys Trp Leu Leu Ser Arg Leu Pro Glu Pro Asn Trp Ala Arg Glu Leu 
        115                 120                 125             


Glu Leu Cys Ala Arg Phe Leu Glu Ala Asp Glu Arg Asn Phe His Cys 
    130                 135                 140                 


Trp Asp Tyr Arg Arg Phe Val Ala Ala Gln Ala Ala Val Ala Pro Ala 
145                 150                 155                 160 


Glu Glu Leu Ala Phe Thr Asp Ser Leu Ile Thr Arg Asn Phe Ser Asn 
                165                 170                 175     


Tyr Ser Ser His Tyr Arg Ser Cys Leu Leu Pro Gln Leu His Pro Gln 
            180                 185                 190         


Pro Asp Ser Gly Pro Gln Gly Arg Leu Pro Glu Asn Val Leu Leu Lys 
        195                 200                 205             


Glu Leu Glu Leu Val Gln Asn Ala Phe Phe Thr Asp Pro Asn Asp Gln 
    210                 215                 220                 


Ser Ala Trp Phe Tyr His Arg Leu Leu Gly Arg Ala Glu Pro His Asp 
225                 230                 235                 240 


Val Leu Cys Cys Val His Val Ser Arg Glu Glu Ala Cys Leu Ser Val 
                245                 250                 255     


Cys Phe Ser Arg Pro Leu Thr Val Gly Ser Arg Met Gly Thr Leu Leu 
            260                 265                 270         


Leu Met Val Asp Glu Ala Pro Leu Ser Val Glu Trp Arg Thr Pro Asp 
        275                 280                 285             


Gly Arg Asn Arg Pro Ser His Val Trp Leu Cys Asp Leu Pro Ala Ala 
    290                 295                 300                 


Ser Leu Asn Asp Gln Leu Pro Gln His Thr Phe Arg Val Ile Trp Thr 
305                 310                 315                 320 


Gly Ser Asp Ser Gln Lys Glu Cys Val Leu Leu Lys Asp Arg Pro Glu 
                325                 330                 335     


Cys Trp Cys Arg Asp Ser Ala Thr Asp Glu Gln Leu Phe Arg Cys Glu 
            340                 345                 350         


Leu Ser Val Glu Lys Ser Thr Val Leu Gln Ser Glu Leu Glu Ser Cys 
        355                 360                 365             


Lys Glu Leu Gln Glu Leu Glu Pro Glu Asn Trp Cys Leu Leu Thr Ile 
    370                 375                 380                 


Ile Leu Leu Met Arg Ala Leu Asp Pro Leu Leu Tyr Glu Lys Glu Thr 
385                 390                 395                 400 


Leu Gln Tyr Phe Ser Thr Leu Lys Ala Val Asp Pro Met Arg Ala Ala 
                405                 410                 415     


Tyr Leu Asp Asp Leu Arg Ser Lys Phe Leu Leu Glu Asn Ser Val Leu 
            420                 425                 430         


Lys Met Glu Tyr Ala Asp Val Arg Val Leu His Leu Ala His Lys Asp 
        435                 440                 445             


Leu Thr Val Leu Cys His Leu Glu Gln Leu Leu Leu Val Thr His Leu 
    450                 455                 460                 


Asp Leu Ser His Asn Arg Leu Arg Ala Leu Pro Pro Ala Leu Ala Ala 
465                 470                 475                 480 


Leu Arg Cys Leu Glu Val Leu Gln Ala Ser Asp Asn Ala Leu Glu Asn 
                485                 490                 495     


Val Asp Gly Val Ala Asn Leu Pro Arg Leu Gln Glu Leu Leu Leu Cys 
            500                 505                 510         


Asn Asn Arg Leu Gln Gln Ser Ala Ala Ile Gln Pro Leu Val Ser Cys 
        515                 520                 525             


Pro Arg Leu Val Leu Leu Asn Leu Gln Gly Asn Ser Leu Cys Gln Glu 
    530                 535                 540                 


Glu Gly Ile Gln Glu Arg Leu Ala Glu Met Leu Pro Ser Val Ser Ser 
545                 550                 555                 560 


Ile Leu Thr 
            


<210> 17
<211> 567
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Met His Gly Arg Leu Lys Val Lys Thr Ser Glu Glu Gln Ala Glu Ala 
1               5                   10                  15      


Lys Arg Leu Glu Arg Glu Gln Lys Leu Lys Leu Tyr Gln Ser Ala Thr 
            20                  25                  30          


Gln Ala Val Phe Gln Lys Arg Gln Ala Gly Glu Leu Asp Glu Ser Val 
        35                  40                  45              


Leu Glu Leu Thr Ser Gln Ile Leu Gly Ala Asn Pro Asp Phe Ala Thr 
    50                  55                  60                  


Leu Trp Asn Cys Arg Arg Glu Val Leu Gln Gln Leu Glu Thr Gln Lys 
65                  70                  75                  80  


Ser Pro Glu Glu Leu Ala Ala Leu Val Lys Ala Glu Leu Gly Phe Leu 
                85                  90                  95      


Glu Ser Cys Leu Arg Val Asn Pro Lys Ser Tyr Gly Thr Trp His His 
            100                 105                 110         


Arg Cys Trp Leu Leu Gly Arg Leu Pro Glu Pro Asn Trp Thr Arg Glu 
        115                 120                 125             


Leu Glu Leu Cys Ala Arg Phe Leu Glu Val Asp Glu Arg Asn Phe His 
    130                 135                 140                 


Cys Trp Asp Tyr Arg Arg Phe Val Ala Thr Gln Ala Ala Val Pro Pro 
145                 150                 155                 160 


Ala Glu Glu Leu Ala Phe Thr Asp Ser Leu Ile Thr Arg Asn Phe Ser 
                165                 170                 175     


Asn Tyr Ser Ser Trp His Tyr Arg Ser Cys Leu Leu Pro Gln Leu His 
            180                 185                 190         


Pro Gln Pro Asp Ser Gly Pro Gln Gly Arg Leu Pro Glu Asp Val Leu 
        195                 200                 205             


Leu Lys Glu Leu Glu Leu Val Gln Asn Ala Phe Phe Thr Asp Pro Asn 
    210                 215                 220                 


Asp Gln Ser Ala Trp Phe Tyr His Arg Trp Leu Leu Gly Arg Ala Asp 
225                 230                 235                 240 


Pro Gln Asp Ala Leu Arg Cys Leu His Val Ser Arg Asp Glu Ala Cys 
                245                 250                 255     


Leu Thr Val Ser Phe Ser Arg Pro Leu Leu Val Gly Ser Arg Met Glu 
            260                 265                 270         


Ile Leu Leu Leu Met Val Asp Asp Ser Pro Leu Ile Val Glu Trp Arg 
        275                 280                 285             


Thr Pro Asp Gly Arg Asn Arg Pro Ser His Val Trp Leu Cys Asp Leu 
    290                 295                 300                 


Pro Ala Ala Ser Leu Asn Asp Gln Leu Pro Gln His Thr Phe Arg Val 
305                 310                 315                 320 


Ile Trp Thr Ala Gly Asp Val Gln Lys Glu Cys Val Leu Leu Lys Gly 
                325                 330                 335     


Arg Gln Glu Gly Trp Cys Arg Asp Ser Thr Thr Asp Glu Gln Leu Phe 
            340                 345                 350         


Arg Cys Glu Leu Ser Val Glu Lys Ser Thr Val Leu Gln Ser Glu Leu 
        355                 360                 365             


Glu Ser Cys Lys Glu Leu Gln Glu Leu Glu Pro Glu Asn Lys Trp Cys 
    370                 375                 380                 


Leu Leu Thr Ile Ile Leu Leu Met Arg Ala Leu Asp Pro Leu Leu Tyr 
385                 390                 395                 400 


Glu Lys Glu Thr Leu Gln Tyr Phe Gln Thr Leu Lys Ala Val Asp Pro 
                405                 410                 415     


Met Arg Ala Thr Tyr Leu Asp Asp Leu Arg Ser Lys Phe Leu Leu Glu 
            420                 425                 430         


Asn Ser Val Leu Lys Met Glu Tyr Ala Glu Val Arg Val Leu His Leu 
        435                 440                 445             


Ala His Lys Asp Leu Thr Val Leu Cys His Leu Glu Gln Leu Leu Leu 
    450                 455                 460                 


Val Thr His Leu Asp Leu Ser His Asn Arg Leu Arg Thr Leu Pro Pro 
465                 470                 475                 480 


Ala Leu Ala Ala Leu Arg Cys Leu Glu Val Leu Gln Ala Ser Asp Asn 
                485                 490                 495     


Ala Ile Glu Ser Leu Asp Gly Val Thr Asn Leu Pro Arg Leu Gln Glu 
            500                 505                 510         


Leu Leu Leu Cys Asn Asn Arg Leu Gln Gln Pro Ala Val Leu Gln Pro 
        515                 520                 525             


Leu Ala Ser Cys Pro Arg Leu Val Leu Leu Asn Leu Gln Gly Asn Pro 
    530                 535                 540                 


Leu Cys Gln Ala Val Gly Ile Leu Glu Gln Leu Ala Glu Leu Leu Pro 
545                 550                 555                 560 


Ser Val Ser Ser Val Leu Thr 
                565         


<210> 18
<211> 567
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Met His Gly Arg Leu Lys Val Lys Thr Ser Glu Glu Gln Ala Glu Ala 
1               5                   10                  15      


Lys Arg Leu Glu Arg Glu Gln Lys Leu Lys Leu Tyr Gln Ser Ala Thr 
            20                  25                  30          


Gln Ala Val Phe Gln Lys Arg Gln Ala Gly Glu Leu Asp Glu Ser Val 
        35                  40                  45              


Leu Glu Leu Thr Ser Gln Ile Leu Gly Ala Asn Pro Asp Phe Ala Thr 
    50                  55                  60                  


Leu Trp Asn Cys Arg Arg Glu Val Leu Gln His Leu Glu Thr Glu Lys 
65                  70                  75                  80  


Ser Pro Glu Glu Ser Ala Ala Leu Val Lys Ala Glu Leu Gly Phe Leu 
                85                  90                  95      


Glu Ser Cys Leu Arg Val Asn Pro Lys Ser Tyr Gly Thr Trp His His 
            100                 105                 110         


Arg Cys Trp Leu Leu Ser Arg Leu Pro Glu Pro Asn Trp Ala Arg Glu 
        115                 120                 125             


Leu Glu Leu Cys Ala Arg Phe Leu Glu Ala Asp Glu Arg Asn Phe His 
    130                 135                 140                 


Cys Trp Asp Tyr Arg Arg Phe Val Ala Ala Gln Ala Ala Val Ala Pro 
145                 150                 155                 160 


Ala Glu Glu Leu Ala Phe Thr Asp Ser Leu Ile Thr Arg Asn Phe Ser 
                165                 170                 175     


Asn Tyr Ser Ser Trp His Tyr Arg Ser Cys Leu Leu Pro Gln Leu His 
            180                 185                 190         


Pro Gln Pro Asp Ser Gly Pro Gln Gly Arg Leu Pro Glu Asn Val Leu 
        195                 200                 205             


Leu Lys Glu Leu Glu Leu Val Gln Asn Ala Phe Phe Thr Asp Pro Asn 
    210                 215                 220                 


Asp Gln Ser Ala Trp Phe Tyr His Arg Trp Leu Leu Gly Arg Ala Glu 
225                 230                 235                 240 


Pro His Asp Val Leu Cys Cys Val His Val Ser Arg Glu Glu Ala Cys 
                245                 250                 255     


Leu Ser Val Cys Phe Ser Arg Pro Leu Thr Val Gly Ser Arg Met Gly 
            260                 265                 270         


Thr Leu Leu Leu Met Val Asp Glu Ala Pro Leu Ser Val Glu Trp Arg 
        275                 280                 285             


Thr Pro Asp Gly Arg Asn Arg Pro Ser His Val Trp Leu Cys Asp Leu 
    290                 295                 300                 


Pro Ala Ala Ser Leu Asn Asp Gln Leu Pro Gln His Thr Phe Arg Val 
305                 310                 315                 320 


Ile Trp Thr Gly Ser Asp Ser Gln Lys Glu Cys Val Leu Leu Lys Asp 
                325                 330                 335     


Arg Pro Glu Cys Trp Cys Arg Asp Ser Ala Thr Asp Glu Gln Leu Phe 
            340                 345                 350         


Arg Cys Glu Leu Ser Val Glu Lys Ser Thr Val Leu Gln Ser Glu Leu 
        355                 360                 365             


Glu Ser Cys Lys Glu Leu Gln Glu Leu Glu Pro Glu Asn Lys Trp Cys 
    370                 375                 380                 


Leu Leu Thr Ile Ile Leu Leu Met Arg Ala Leu Asp Pro Leu Leu Tyr 
385                 390                 395                 400 


Glu Lys Glu Thr Leu Gln Tyr Phe Ser Thr Leu Lys Ala Val Asp Pro 
                405                 410                 415     


Met Arg Ala Ala Tyr Leu Asp Asp Leu Arg Ser Lys Phe Leu Leu Glu 
            420                 425                 430         


Asn Ser Val Leu Lys Met Glu Tyr Ala Asp Val Arg Val Leu His Leu 
        435                 440                 445             


Ala His Lys Asp Leu Thr Val Leu Cys His Leu Glu Gln Leu Leu Leu 
    450                 455                 460                 


Val Thr His Leu Asp Leu Ser His Asn Arg Leu Arg Ala Leu Pro Pro 
465                 470                 475                 480 


Ala Leu Ala Ala Leu Arg Cys Leu Glu Val Leu Gln Ala Ser Asp Asn 
                485                 490                 495     


Ala Leu Glu Asn Val Asp Gly Val Ala Asn Leu Pro Arg Leu Gln Glu 
            500                 505                 510         


Leu Leu Leu Cys Asn Asn Arg Leu Gln Gln Ser Ala Ala Ile Gln Pro 
        515                 520                 525             


Leu Val Ser Cys Pro Arg Leu Val Leu Leu Asn Leu Gln Gly Asn Ser 
    530                 535                 540                 


Leu Cys Gln Glu Glu Gly Ile Gln Glu Arg Leu Ala Glu Met Leu Pro 
545                 550                 555                 560 


Ser Val Ser Ser Ile Leu Thr 
                565         


<210> 19
<211> 331
<212> PRT
<213> Homo sapiens

<400> 19
Met Gly Thr Pro Gln Lys Asp Val Ile Ile Lys Ser Asp Ala Pro Asp 
1               5                   10                  15      


Thr Leu Leu Leu Glu Lys His Ala Asp Tyr Ile Ala Ser Tyr Gly Ser 
            20                  25                  30          


Lys Lys Asp Asp Tyr Glu Tyr Cys Met Ser Glu Tyr Leu Arg Met Ser 
        35                  40                  45              


Gly Ile Tyr Trp Gly Leu Thr Val Met Asp Leu Met Gly Gln Leu His 
    50                  55                  60                  


Arg Met Asn Arg Glu Glu Ile Leu Ala Phe Ile Lys Ser Cys Gln His 
65                  70                  75                  80  


Glu Cys Gly Gly Ile Ser Ala Ser Ile Gly His Asp Pro His Leu Leu 
                85                  90                  95      


Tyr Thr Leu Ser Ala Val Gln Ile Leu Thr Leu Tyr Asp Ser Ile Asn 
            100                 105                 110         


Val Ile Asp Val Asn Lys Val Val Glu Tyr Val Lys Gly Leu Gln Lys 
        115                 120                 125             


Glu Asp Gly Ser Phe Ala Gly Asp Ile Trp Gly Glu Ile Asp Thr Arg 
    130                 135                 140                 


Phe Ser Phe Cys Ala Val Ala Thr Leu Ala Leu Leu Gly Lys Leu Asp 
145                 150                 155                 160 


Ala Ile Asn Val Glu Lys Ala Ile Glu Phe Val Leu Ser Cys Met Asn 
                165                 170                 175     


Phe Asp Gly Gly Phe Gly Cys Arg Pro Gly Ser Glu Ser His Ala Gly 
            180                 185                 190         


Gln Ile Tyr Cys Cys Thr Gly Phe Leu Ala Ile Thr Ser Gln Leu His 
        195                 200                 205             


Gln Val Asn Ser Asp Leu Leu Gly Trp Trp Leu Cys Glu Arg Gln Leu 
    210                 215                 220                 


Pro Ser Gly Gly Leu Asn Gly Arg Pro Glu Lys Leu Pro Asp Val Cys 
225                 230                 235                 240 


Tyr Ser Trp Trp Val Leu Ala Ser Leu Lys Ile Ile Gly Arg Leu His 
                245                 250                 255     


Trp Ile Asp Arg Glu Lys Leu Arg Asn Phe Ile Leu Ala Cys Gln Asp 
            260                 265                 270         


Glu Glu Thr Gly Gly Phe Ala Asp Arg Pro Gly Asp Met Val Asp Pro 
        275                 280                 285             


Phe His Thr Leu Phe Gly Ile Ala Gly Leu Ser Leu Leu Gly Glu Glu 
    290                 295                 300                 


Gln Ile Lys Pro Val Asn Pro Val Phe Cys Met Pro Glu Glu Val Leu 
305                 310                 315                 320 


Gln Arg Val Asn Val Gln Pro Glu Leu Val Ser 
                325                 330     


<210> 20
<211> 331
<212> PRT
<213> Rattus norvegicus

<400> 20
Met Gly Thr Gln Gln Lys Asp Val Thr Ile Lys Ser Asp Ala Pro Asp 
1               5                   10                  15      


Thr Leu Leu Leu Glu Lys His Ala Asp Tyr Ile Ala Ser Tyr Gly Ser 
            20                  25                  30          


Lys Lys Asp Asp Tyr Glu Tyr Cys Met Ser Glu Tyr Leu Arg Met Ser 
        35                  40                  45              


Gly Val Tyr Trp Gly Leu Thr Val Met Asp Leu Met Gly Gln Leu His 
    50                  55                  60                  


Arg Met Asn Lys Glu Glu Ile Leu Val Phe Ile Lys Ser Cys Gln His 
65                  70                  75                  80  


Glu Cys Gly Gly Val Ser Ala Ser Ile Gly His Asp Pro His Leu Leu 
                85                  90                  95      


Tyr Thr Leu Ser Ala Val Gln Ile Leu Thr Leu Tyr Asp Ser Ile His 
            100                 105                 110         


Val Ile Asn Val Asp Lys Val Val Ala Tyr Val Gln Ser Leu Gln Lys 
        115                 120                 125             


Glu Asp Gly Ser Phe Ala Gly Asp Ile Trp Gly Glu Ile Asp Thr Arg 
    130                 135                 140                 


Phe Ser Phe Cys Ala Val Ala Thr Leu Ala Leu Leu Gly Lys Leu Asp 
145                 150                 155                 160 


Ala Ile Asn Val Glu Lys Ala Ile Glu Phe Val Leu Ser Cys Met Asn 
                165                 170                 175     


Phe Asp Gly Gly Phe Gly Cys Arg Pro Gly Ser Glu Ser His Ala Gly 
            180                 185                 190         


Gln Ile Tyr Cys Cys Thr Gly Phe Leu Ala Ile Thr Ser Gln Leu His 
        195                 200                 205             


Gln Val Asn Ser Asp Leu Leu Gly Trp Trp Leu Cys Glu Arg Gln Leu 
    210                 215                 220                 


Pro Ser Gly Gly Leu Asn Gly Arg Pro Glu Lys Leu Pro Asp Val Cys 
225                 230                 235                 240 


Tyr Ser Trp Trp Val Leu Ala Ser Leu Lys Ile Ile Gly Arg Leu His 
                245                 250                 255     


Trp Ile Asp Arg Glu Lys Leu Arg Ser Phe Ile Leu Ala Cys Gln Asp 
            260                 265                 270         


Glu Glu Thr Gly Gly Phe Ala Asp Arg Pro Gly Asp Met Val Asp Pro 
        275                 280                 285             


Phe His Thr Leu Phe Gly Ile Ala Gly Leu Ser Leu Leu Gly Glu Glu 
    290                 295                 300                 


Gln Ile Lys Pro Val Ser Pro Val Phe Cys Met Pro Glu Glu Val Leu 
305                 310                 315                 320 


Gln Arg Val Asn Val Gln Pro Glu Leu Val Ser 
                325                 330     


<210> 21
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Met Gly Thr Pro Gln Lys Asp Val Ile Ile Lys Ser Asp Ala Pro Asp 
1               5                   10                  15      


Thr Leu Leu Leu Glu Lys His Ala Asp Tyr Ile Ala Ser Tyr Gly Ser 
            20                  25                  30          


Lys Lys Asp Asp Tyr Glu Tyr Cys Met Ser Glu Tyr Leu Arg Met Ser 
        35                  40                  45              


Gly Ile Tyr Trp Gly Leu Thr Val Met Asp Leu Met Gly Gln Leu His 
    50                  55                  60                  


Arg Met Asn Arg Glu Glu Ile Leu Ala Phe Ile Lys Ser Cys Gln His 
65                  70                  75                  80  


Glu Cys Gly Gly Ile Ser Ala Ser Ile Gly His Asp Pro His Leu Leu 
                85                  90                  95      


Tyr Thr Leu Ser Ala Val Gln Ile Leu Thr Leu Tyr Asp Ser Ile Asn 
            100                 105                 110         


Val Ile Asp Val Asn Lys Val Val Glu Tyr Val Lys Gly Leu Gln Lys 
        115                 120                 125             


Glu Asp Gly Ser Phe Ala Gly Asp Ile Trp Gly Glu Ile Asp Thr Arg 
    130                 135                 140                 


Phe Ser Phe Cys Ala Val Ala Thr Leu Ala Leu Leu Gly Lys Leu Asp 
145                 150                 155                 160 


Ala Ile Asn Val Glu Lys Ala Ile Glu Phe Val Leu Ser Cys Met Asn 
                165                 170                 175     


Phe Asp Gly Gly Phe Gly Cys Arg Pro Gly Ser Glu Ser His Ala Gly 
            180                 185                 190         


Gln Ile Tyr Cys Cys Thr Gly Phe Leu Ala Ile Thr Ser Gln Leu His 
        195                 200                 205             


Gln Val Asn Ser Asp Leu Leu Gly Trp Trp Leu Cys Glu Arg Gln Leu 
    210                 215                 220                 


Pro Ser Gly Gly Leu Asn Gly Arg Pro Glu Lys Leu Pro Asp Val Cys 
225                 230                 235                 240 


Tyr Ser Trp Trp Val Leu Ala Ser Leu Lys Ile Ile Gly Arg Leu His 
                245                 250                 255     


Trp Ile Asp Arg Glu Lys Leu Arg Asn Phe Ile Leu Ala Cys Gln Asp 
            260                 265                 270         


Glu Glu Thr Gly Gly Phe Ala Asp Arg Pro Gly Asp Met Val Asp Pro 
        275                 280                 285             


Phe His Thr Leu Phe Gly Ile Ala Gly Leu Ser Leu Leu Gly Glu Glu 
    290                 295                 300                 


Gln Ile Lys Pro Val Asn Pro Val Phe Cys Met Pro Glu Glu Val Leu 
305                 310                 315                 320 


Gln Arg Val Asn Val Gln Pro Glu Leu Val Ser 
                325                 330     


<210> 22
<211> 328
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 22
Met Gly Thr Gln Gln Lys Asp Val Thr Ile Lys Ser Asp Ala Pro Asp 
1               5                   10                  15      


Thr Leu Leu Leu Glu Lys His Ala Asp Tyr Ile Ala Ser Tyr Gly Ser 
            20                  25                  30          


Lys Lys Asp Asp Tyr Glu Tyr Cys Met Ser Glu Tyr Leu Arg Met Ser 
        35                  40                  45              


Gly Val Tyr Trp Gly Leu Thr Val Met Asp Leu Met Gly Gln Leu His 
    50                  55                  60                  


Arg Met Asn Lys Glu Glu Ile Leu Val Phe Ile Lys Ser Cys Gln His 
65                  70                  75                  80  


Glu Cys Gly Gly Val Ser Ala Ser Ile Gly His Asp Pro His Leu Leu 
                85                  90                  95      


Tyr Thr Leu Ser Ala Val Gln Ile Leu Thr Leu Tyr Asp Ser Ile His 
            100                 105                 110         


Val Ile Asn Val Asp Lys Val Val Ala Tyr Val Gln Ser Leu Gln Glu 
        115                 120                 125             


Asp Gly Ser Phe Ala Gly Asp Ile Gly Glu Ile Asp Thr Arg Phe Ser 
    130                 135                 140                 


Phe Cys Ala Val Ala Thr Leu Ala Leu Leu Gly Lys Leu Asp Ala Ile 
145                 150                 155                 160 


Asn Val Glu Lys Ala Ile Glu Phe Val Leu Ser Cys Met Asn Phe Asp 
                165                 170                 175     


Gly Gly Phe Gly Cys Arg Pro Gly Ser Glu Ser His Ala Gly Gln Ile 
            180                 185                 190         


Tyr Cys Cys Thr Gly Phe Leu Ala Ile Thr Ser Gln Leu His Gln Val 
        195                 200                 205             


Asn Ser Asp Leu Leu Gly Trp Trp Leu Cys Glu Arg Gln Leu Pro Ser 
    210                 215                 220                 


Gly Gly Leu Asn Gly Arg Pro Glu Lys Leu Pro Asp Val Cys Tyr Ser 
225                 230                 235                 240 


Trp Trp Val Leu Ala Ser Leu Lys Ile Ile Gly Arg Leu His Ile Asp 
                245                 250                 255     


Arg Glu Lys Leu Arg Ser Phe Ile Leu Ala Cys Gln Asp Glu Glu Thr 
            260                 265                 270         


Gly Gly Phe Ala Asp Arg Pro Gly Asp Met Val Asp Pro Phe His Thr 
        275                 280                 285             


Leu Phe Gly Ile Ala Gly Leu Ser Leu Leu Gly Glu Glu Gln Ile Lys 
    290                 295                 300                 


Pro Val Ser Pro Val Phe Cys Met Pro Glu Glu Val Leu Gln Arg Val 
305                 310                 315                 320 


Asn Val Gln Pro Glu Leu Val Ser 
                325             


<210> 23
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 23
Met Gly Thr Gln Gln Lys Asp Val Thr Ile Lys Ser Asp Ala Pro Asp 
1               5                   10                  15      


Thr Leu Leu Leu Glu Lys His Ala Asp Tyr Ile Ala Ser Tyr Gly Ser 
            20                  25                  30          


Lys Lys Asp Asp Tyr Glu Tyr Cys Met Ser Glu Tyr Leu Arg Met Ser 
        35                  40                  45              


Gly Val Tyr Trp Gly Leu Thr Val Met Asp Leu Met Gly Gln Leu His 
    50                  55                  60                  


Arg Met Asn Lys Glu Glu Ile Leu Val Phe Ile Lys Ser Cys Gln His 
65                  70                  75                  80  


Glu Cys Gly Gly Val Ser Ala Ser Ile Gly His Asp Pro His Leu Leu 
                85                  90                  95      


Tyr Thr Leu Ser Ala Val Gln Ile Leu Thr Leu Tyr Asp Ser Ile His 
            100                 105                 110         


Val Ile Asn Val Asp Lys Val Val Ala Tyr Val Gln Ser Leu Gln Lys 
        115                 120                 125             


Glu Asp Gly Ser Phe Ala Gly Asp Ile Trp Gly Glu Ile Asp Thr Arg 
    130                 135                 140                 


Phe Ser Phe Cys Ala Val Ala Thr Leu Ala Leu Leu Gly Lys Leu Asp 
145                 150                 155                 160 


Ala Ile Asn Val Glu Lys Ala Ile Glu Phe Val Leu Ser Cys Met Asn 
                165                 170                 175     


Phe Asp Gly Gly Phe Gly Cys Arg Pro Gly Ser Glu Ser His Ala Gly 
            180                 185                 190         


Gln Ile Tyr Cys Cys Thr Gly Phe Leu Ala Ile Thr Ser Gln Leu His 
        195                 200                 205             


Gln Val Asn Ser Asp Leu Leu Gly Trp Trp Leu Cys Glu Arg Gln Leu 
    210                 215                 220                 


Pro Ser Gly Gly Leu Asn Gly Arg Pro Glu Lys Leu Pro Asp Val Cys 
225                 230                 235                 240 


Tyr Ser Trp Trp Val Leu Ala Ser Leu Lys Ile Ile Gly Arg Leu His 
                245                 250                 255     


Trp Ile Asp Arg Glu Lys Leu Arg Ser Phe Ile Leu Ala Cys Gln Asp 
            260                 265                 270         


Glu Glu Thr Gly Gly Phe Ala Asp Arg Pro Gly Asp Met Val Asp Pro 
        275                 280                 285             


Phe His Thr Leu Phe Gly Ile Ala Gly Leu Ser Leu Leu Gly Glu Glu 
    290                 295                 300                 


Gln Ile Lys Pro Val Ser Pro Val Phe Cys Met Pro Glu Glu Val Leu 
305                 310                 315                 320 


Gln Arg Val Asn Val Gln Pro Glu Leu Val Ser 
                325                 330     


