                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  NOVEL VAR2CSA IMMUNOGENS AND METHODS OF USE THEREOF

<130>  758113

<150>  US 63/115,729
<151>  2020-11-19

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  2642
<212>  PRT
<213>  Plasmodium falciparum

<400>  1

Met Asp Lys Ser Ser Ile Ala Asn Lys Ile Glu Ala Tyr Leu Gly Ala 
1               5                   10                  15      


Lys Ser Asp Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Arg Lys 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
            100                 105                 110         


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
                165                 170                 175     


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
        195                 200                 205             


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
    210                 215                 220                 


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
225                 230                 235                 240 


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
                245                 250                 255     


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
            260                 265                 270         


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
        275                 280                 285             


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
    290                 295                 300                 


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
305                 310                 315                 320 


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
                325                 330                 335     


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
            340                 345                 350         


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
        355                 360                 365             


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
    370                 375                 380                 


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
385                 390                 395                 400 


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
                405                 410                 415     


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
            420                 425                 430         


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
        435                 440                 445             


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
    450                 455                 460                 


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
465                 470                 475                 480 


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
                485                 490                 495     


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
            500                 505                 510         


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
        515                 520                 525             


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
    530                 535                 540                 


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
545                 550                 555                 560 


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
                565                 570                 575     


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
            580                 585                 590         


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
        595                 600                 605             


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
    610                 615                 620                 


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
625                 630                 635                 640 


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
                645                 650                 655     


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
            660                 665                 670         


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
        675                 680                 685             


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
    690                 695                 700                 


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
705                 710                 715                 720 


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly 
                725                 730                 735     


Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp 
            740                 745                 750         


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
        755                 760                 765             


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys Lys 
    770                 775                 780                 


Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Glu 
785                 790                 795                 800 


Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Asp Cys Lys 
                805                 810                 815     


Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln 
            820                 825                 830         


Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg 
        835                 840                 845             


Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala 
    850                 855                 860                 


Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu 
865                 870                 875                 880 


Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu 
                885                 890                 895     


Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr 
            900                 905                 910         


Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser Lys 
        915                 920                 925             


Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu 
    930                 935                 940                 


Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro 
945                 950                 955                 960 


Thr Asn Glu Glu Thr Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp 
                965                 970                 975     


Ser Cys Gly Ser Ala Arg Thr Met Lys Arg Gly Tyr Lys Asn Asp Asn 
            980                 985                 990         


Tyr Glu Leu Cys Lys Tyr Asn Gly  Val Asp Val Lys Pro  Thr Thr Val 
        995                 1000                 1005             


Arg Ser  Asn Ser Ser Lys Leu  Asp Asp Lys Asp Val  Thr Phe Phe 
    1010                 1015                 1020             


Asn Leu  Phe Glu Gln Trp Asn  Lys Glu Ile Gln Tyr  Gln Ile Glu 
    1025                 1030                 1035             


Gln Tyr  Met Thr Asn Thr Lys  Ile Ser Cys Asn Asn  Glu Lys Asn 
    1040                 1045                 1050             


Val Leu  Ser Arg Val Ser Asp  Glu Ala Ala Gln Pro  Lys Phe Ser 
    1055                 1060                 1065             


Asp Asn  Glu Arg Asp Arg Asn  Ser Ile Thr His Glu  Asp Lys Asn 
    1070                 1075                 1080             


Cys Lys  Glu Lys Cys Lys Cys  Tyr Ser Leu Trp Ile  Glu Lys Ile 
    1085                 1090                 1095             


Asn Asp  Gln Trp Asp Lys Gln  Lys Asp Asn Tyr Asn  Lys Phe Gln 
    1100                 1105                 1110             


Arg Lys  Gln Ile Tyr Asp Ala  Asn Lys Gly Ser Gln  Asn Lys Lys 
    1115                 1120                 1125             


Val Val  Ser Leu Ser Asn Phe  Leu Phe Phe Ser Cys  Trp Glu Glu 
    1130                 1135                 1140             


Tyr Ile  Gln Lys Tyr Phe Asn  Gly Asp Trp Ser Lys  Ile Lys Asn 
    1145                 1150                 1155             


Ile Gly  Ser Asp Thr Phe Glu  Phe Leu Ile Lys Lys  Cys Gly Asn 
    1160                 1165                 1170             


Asp Ser  Gly Asp Gly Glu Thr  Ile Phe Ser Glu Lys  Leu Asn Asn 
    1175                 1180                 1185             


Ala Glu  Lys Lys Cys Lys Glu  Asn Glu Ser Thr Asn  Asn Lys Met 
    1190                 1195                 1200             


Lys Ser  Ser Glu Thr Ser Cys  Asp Cys Ser Glu Pro  Ile Tyr Ile 
    1205                 1210                 1215             


Arg Gly  Cys Gln Pro Lys Ile  Tyr Asp Gly Lys Ile  Phe Pro Gly 
    1220                 1225                 1230             


Lys Gly  Gly Glu Lys Gln Trp  Ile Cys Lys Asp Thr  Ile Ile His 
    1235                 1240                 1245             


Gly Asp  Thr Asn Gly Ala Cys  Ile Pro Pro Arg Thr  Gln Asn Leu 
    1250                 1255                 1260             


Cys Val  Gly Glu Leu Trp Asp  Lys Arg Tyr Gly Gly  Arg Ser Asn 
    1265                 1270                 1275             


Ile Lys  Asn Asp Thr Lys Glu  Ser Leu Lys Gln Lys  Ile Lys Asn 
    1280                 1285                 1290             


Ala Ile  Gln Lys Glu Thr Glu  Leu Leu Tyr Glu Tyr  His Asp Lys 
    1295                 1300                 1305             


Gly Thr  Ala Ile Ile Ser Arg  Asn Pro Met Lys Gly  Gln Lys Glu 
    1310                 1315                 1320             


Lys Glu  Glu Lys Asn Asn Asp  Ser Asn Gly Leu Pro  Lys Gly Phe 
    1325                 1330                 1335             


Cys His  Ala Val Gln Arg Ser  Phe Ile Asp Tyr Lys  Asn Met Ile 
    1340                 1345                 1350             


Leu Gly  Thr Ser Val Asn Ile  Tyr Glu Tyr Ile Gly  Lys Leu Gln 
    1355                 1360                 1365             


Glu Asp  Ile Lys Lys Ile Ile  Glu Lys Gly Thr Thr  Lys Gln Asn 
    1370                 1375                 1380             


Gly Lys  Thr Val Gly Ser Gly  Ala Glu Asn Val Asn  Ala Trp Trp 
    1385                 1390                 1395             


Lys Gly  Ile Glu Gly Glu Met  Trp Asp Ala Val Arg  Cys Ala Ile 
    1400                 1405                 1410             


Thr Lys  Ile Asn Lys Lys Gln  Lys Lys Asn Gly Thr  Phe Ser Ile 
    1415                 1420                 1425             


Asp Glu  Cys Gly Ile Phe Pro  Pro Thr Gly Asn Asp  Glu Asp Gln 
    1430                 1435                 1440             


Ser Val  Ser Trp Phe Lys Glu  Trp Ser Glu Gln Phe  Cys Ile Glu 
    1445                 1450                 1455             


Arg Leu  Gln Tyr Glu Lys Asn  Ile Arg Asp Ala Cys  Thr Asn Asn 
    1460                 1465                 1470             


Gly Gln  Gly Asp Lys Ile Gln  Gly Asp Cys Lys Arg  Lys Cys Glu 
    1475                 1480                 1485             


Glu Tyr  Lys Lys Tyr Ile Ser  Glu Lys Lys Gln Glu  Trp Asp Lys 
    1490                 1495                 1500             


Gln Lys  Thr Lys Tyr Glu Asn  Lys Tyr Val Gly Lys  Ser Ala Ser 
    1505                 1510                 1515             


Asp Leu  Leu Lys Glu Asn Tyr  Pro Glu Cys Ile Ser  Ala Asn Phe 
    1520                 1525                 1530             


Asp Phe  Ile Phe Asn Asp Asn  Ile Glu Tyr Lys Thr  Tyr Tyr Pro 
    1535                 1540                 1545             


Tyr Gly  Asp Tyr Ser Ser Ile  Cys Ser Cys Glu Gln  Val Lys Tyr 
    1550                 1555                 1560             


Tyr Glu  Tyr Asn Asn Ala Glu  Lys Lys Asn Asn Lys  Ser Leu Cys 
    1565                 1570                 1575             


His Glu  Lys Gly Asn Asp Arg  Thr Trp Ser Lys Lys  Tyr Ile Lys 
    1580                 1585                 1590             


Lys Leu  Glu Asn Gly Arg Thr  Leu Glu Gly Val Tyr  Val Pro Pro 
    1595                 1600                 1605             


Arg Arg  Gln Gln Leu Cys Leu  Tyr Glu Leu Phe Pro  Ile Ile Ile 
    1610                 1615                 1620             


Lys Asn  Lys Asn Asp Ile Thr  Asn Ala Lys Lys Glu  Leu Leu Glu 
    1625                 1630                 1635             


Thr Leu  Gln Ile Val Ala Glu  Arg Glu Ala Tyr Tyr  Leu Trp Lys 
    1640                 1645                 1650             


Gln Tyr  His Ala His Asn Asp  Thr Thr Tyr Leu Ala  His Lys Lys 
    1655                 1660                 1665             


Ala Cys  Cys Ala Ile Arg Gly  Ser Phe Tyr Asp Leu  Glu Asp Ile 
    1670                 1675                 1680             


Ile Lys  Gly Asn Asp Leu Val  His Asp Glu Tyr Thr  Lys Tyr Ile 
    1685                 1690                 1695             


Asp Ser  Lys Leu Asn Glu Ile  Phe Asp Ser Ser Asn  Lys Asn Asp 
    1700                 1705                 1710             


Ile Glu  Thr Lys Arg Ala Arg  Thr Asp Trp Trp Glu  Asn Glu Ala 
    1715                 1720                 1725             


Ile Ala  Val Pro Asn Ile Thr  Gly Ala Asn Lys Ser  Asp Pro Lys 
    1730                 1735                 1740             


Thr Ile  Arg Gln Leu Val Trp  Asp Ala Met Gln Ser  Gly Val Arg 
    1745                 1750                 1755             


Lys Ala  Ile Asp Glu Glu Lys  Glu Lys Lys Lys Pro  Asn Glu Asn 
    1760                 1765                 1770             


Phe Pro  Pro Cys Met Gly Val  Gln His Ile Gly Ile  Ala Lys Pro 
    1775                 1780                 1785             


Gln Phe  Ile Arg Trp Leu Glu  Glu Trp Thr Asn Glu  Phe Cys Glu 
    1790                 1795                 1800             


Lys Tyr  Thr Lys Tyr Phe Glu  Asp Met Lys Ser Asn  Cys Asn Leu 
    1805                 1810                 1815             


Arg Lys  Gly Ala Asp Asp Cys  Asp Asp Asn Ser Asn  Ile Glu Cys 
    1820                 1825                 1830             


Lys Lys  Ala Cys Ala Asn Tyr  Thr Asn Trp Leu Asn  Pro Lys Arg 
    1835                 1840                 1845             


Ile Glu  Trp Asn Gly Met Ser  Asn Tyr Tyr Asn Lys  Ile Tyr Arg 
    1850                 1855                 1860             


Lys Ser  Asn Lys Glu Ser Glu  Asp Gly Lys Asp Tyr  Ser Met Ile 
    1865                 1870                 1875             


Met Glu  Pro Thr Val Ile Asp  Tyr Leu Asn Lys Arg  Cys Asn Gly 
    1880                 1885                 1890             


Glu Ile  Asn Gly Asn Tyr Ile  Cys Cys Ser Cys Lys  Asn Ile Gly 
    1895                 1900                 1905             


Glu Asn  Ser Thr Ser Gly Thr  Val Asn Lys Lys Leu  Gln Lys Lys 
    1910                 1915                 1920             


Glu Thr  Gln Cys Glu Asp Asn  Lys Gly Pro Leu Asp  Leu Met Asn 
    1925                 1930                 1935             


Lys Val  Leu Asn Lys Met Asp  Pro Lys Tyr Ser Glu  His Lys Met 
    1940                 1945                 1950             


Lys Cys  Thr Glu Val Tyr Leu  Glu His Val Glu Glu  Gln Leu Lys 
    1955                 1960                 1965             


Glu Ile  Asp Asn Ala Ile Lys  Asp Tyr Lys Leu Tyr  Pro Leu Asp 
    1970                 1975                 1980             


Arg Cys  Phe Asp Asp Lys Ser  Lys Met Lys Val Cys  Asp Leu Ile 
    1985                 1990                 1995             


Gly Asp  Ala Ile Gly Cys Lys  His Lys Thr Lys Leu  Asp Glu Leu 
    2000                 2005                 2010             


Asp Glu  Trp Asn Asp Val Asp  Met Arg Asp Pro Tyr  Asn Lys Tyr 
    2015                 2020                 2025             


Lys Gly  Val Leu Ile Pro Pro  Arg Arg Arg Gln Leu  Cys Phe Ser 
    2030                 2035                 2040             


Arg Ile  Val Arg Gly Pro Ala  Asn Leu Arg Asn Leu  Lys Glu Phe 
    2045                 2050                 2055             


Lys Glu  Glu Ile Leu Lys Gly  Ala Gln Ser Glu Gly  Lys Phe Leu 
    2060                 2065                 2070             


Gly Asn  Tyr Tyr Asn Glu Asp  Lys Asp Lys Glu Lys  Ala Leu Glu 
    2075                 2080                 2085             


Ala Met  Lys Asn Ser Phe Tyr  Asp Tyr Glu Tyr Ile  Ile Lys Gly 
    2090                 2095                 2100             


Ser Asp  Met Leu Thr Asn Ile  Gln Phe Lys Asp Ile  Lys Arg Lys 
    2105                 2110                 2115             


Leu Asp  Arg Leu Leu Glu Lys  Glu Thr Asn Asn Thr  Glu Lys Val 
    2120                 2125                 2130             


Asp Asp  Trp Trp Glu Thr Asn  Lys Lys Ser Ile Trp  Asn Ala Met 
    2135                 2140                 2145             


Leu Cys  Gly Tyr Lys Lys Ser  Gly Asn Lys Ile Ile  Asp Pro Ser 
    2150                 2155                 2160             


Trp Cys  Thr Ile Pro Thr Thr  Glu Thr Pro Pro Gln  Phe Leu Arg 
    2165                 2170                 2175             


Trp Ile  Lys Glu Trp Gly Thr  Asn Val Cys Ile Gln  Lys Glu Glu 
    2180                 2185                 2190             


His Lys  Glu Tyr Val Lys Ser  Lys Cys Ser Asn Val  Thr Asn Leu 
    2195                 2200                 2205             


Gly Ala  Gln Glu Ser Glu Ser  Lys Asn Cys Thr Ser  Glu Ile Lys 
    2210                 2215                 2220             


Lys Tyr  Gln Glu Trp Ser Arg  Lys Arg Ser Ile Gln  Trp Glu Ala 
    2225                 2230                 2235             


Ile Ser  Glu Gly Tyr Lys Lys  Tyr Lys Gly Met Asp  Glu Phe Lys 
    2240                 2245                 2250             


Asn Thr  Phe Lys Asn Ile Lys  Glu Pro Asp Ala Asn  Glu Pro Asn 
    2255                 2260                 2265             


Ala Asn  Glu Tyr Leu Lys Lys  His Cys Ser Lys Cys  Pro Cys Gly 
    2270                 2275                 2280             


Phe Asn  Asp Met Gln Glu Ile  Thr Lys Tyr Thr Asn  Ile Gly Asn 
    2285                 2290                 2295             


Glu Ala  Phe Lys Gln Ile Lys  Glu Gln Val Asp Ile  Pro Ala Glu 
    2300                 2305                 2310             


Leu Glu  Asp Val Ile Tyr Arg  Leu Lys His His Glu  Tyr Asp Lys 
    2315                 2320                 2325             


Gly Asn  Asp Tyr Ile Cys Asn  Lys Tyr Lys Asn Ile  Asn Val Asn 
    2330                 2335                 2340             


Met Lys  Lys Asn Asn Asp Asp  Thr Trp Thr Asp Leu  Val Lys Asn 
    2345                 2350                 2355             


Ser Ser  Asp Ile Asn Lys Gly  Val Leu Leu Pro Pro  Arg Arg Lys 
    2360                 2365                 2370             


Asn Leu  Phe Leu Lys Ile Asp  Glu Ser Asp Ile Cys  Lys Tyr Lys 
    2375                 2380                 2385             


Arg Asp  Pro Lys Leu Phe Lys  Asp Phe Ile Tyr Ser  Ser Ala Ile 
    2390                 2395                 2400             


Ser Glu  Val Glu Arg Leu Lys  Lys Val Tyr Gly Glu  Ala Lys Thr 
    2405                 2410                 2415             


Lys Val  Val His Ala Met Lys  Tyr Ser Phe Ala Asp  Ile Gly Ser 
    2420                 2425                 2430             


Ile Ile  Lys Gly Asp Asp Met  Met Glu Asn Asn Ser  Ser Asp Lys 
    2435                 2440                 2445             


Ile Gly  Lys Ile Leu Gly Asp  Gly Val Gly Gln Asn  Glu Lys Arg 
    2450                 2455                 2460             


Lys Lys  Trp Trp Asp Met Asn  Lys Tyr His Ile Trp  Glu Ser Met 
    2465                 2470                 2475             


Leu Cys  Gly Tyr Lys His Ala  Tyr Gly Asn Ile Ser  Glu Asn Asp 
    2480                 2485                 2490             


Arg Lys  Met Leu Asp Ile Pro  Asn Asn Asp Asp Glu  His Gln Phe 
    2495                 2500                 2505             


Leu Arg  Trp Phe Gln Glu Trp  Thr Glu Asn Phe Cys  Thr Lys Arg 
    2510                 2515                 2520             


Asn Glu  Leu Tyr Glu Asn Met  Val Thr Ala Cys Asn  Ser Ala Lys 
    2525                 2530                 2535             


Cys Asn  Thr Ser Asn Gly Ser  Val Asp Lys Lys Glu  Cys Thr Glu 
    2540                 2545                 2550             


Ala Cys  Lys Asn Tyr Ser Asn  Phe Ile Leu Ile Lys  Lys Lys Glu 
    2555                 2560                 2565             


Tyr Gln  Ser Leu Asn Ser Gln  Tyr Asp Met Asn Tyr  Lys Glu Thr 
    2570                 2575                 2580             


Lys Ala  Glu Lys Lys Glu Ser  Pro Glu Tyr Phe Lys  Asp Lys Cys 
    2585                 2590                 2595             


Asn Gly  Glu Cys Ser Cys Leu  Ser Glu Tyr Phe Lys  Asp Glu Thr 
    2600                 2605                 2610             


Arg Trp  Lys Asn Pro Tyr Glu  Thr Leu Asp Asp Thr  Glu Val Lys 
    2615                 2620                 2625             


Asn Asn  Cys Met Cys Lys Pro  Pro Pro Pro Ala Ser  Asn Asn 
    2630                 2635                 2640         


<210>  2
<211>  2649
<212>  PRT
<213>  Plasmodium falciparum

<400>  2

Met Asp Ser Thr Ser Thr Ile Ala Asn Lys Ile Glu Glu Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asp Asp Ser Lys Ile Asp Glu Leu Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Asp Pro Cys Glu Lys Lys Leu Pro Pro Tyr Asp Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Gly Lys Pro Glu Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Glu Arg Leu Cys Thr Tyr Asn Leu Glu Asn 
            100                 105                 110         


Leu Lys Phe Asp Lys Ile Arg Asp Asn Asn Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Lys Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Lys Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu 
            180                 185                 190         


Asn Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Lys Tyr Thr 
        195                 200                 205             


Lys Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly 
225                 230                 235                 240 


Trp Arg Thr Ser Gly Lys Ser Asp Arg Lys Lys Asn Phe Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Lys Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr 
        275                 280                 285             


Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser 
305                 310                 315                 320 


Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp 
                325                 330                 335     


Lys Thr Glu Trp Glu Asn Gln Glu Asn Lys Tyr Lys Asp Leu Tyr Glu 
            340                 345                 350         


Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp 
        355                 360                 365             


Tyr Val Lys Asp Phe Phe Glu Lys Leu Glu Ala Asn Tyr Ser Ser Leu 
    370                 375                 380                 


Glu Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys 
385                 390                 395                 400 


Leu Ser Phe Ile Leu Asn Pro Ser Asp Ala Asn Asn Pro Ser Gly Glu 
                405                 410                 415     


Thr Ala Asn His Asn Asp Glu Ala Cys Asn Cys Asn Glu Ser Gly Ile 
            420                 425                 430         


Ser Ser Val Gly Gln Ala Gln Thr Ser Gly Pro Ser Ser Asn Lys Thr 
        435                 440                 445             


Cys Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Glu Cys Lys 
    450                 455                 460                 


Asp Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Lys Ile Cys 
465                 470                 475                 480 


Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys Gln 
                485                 490                 495     


Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg Gly 
            500                 505                 510         


Ser Ser Ser Asn Asp Ser Cys Asp Asn Lys Asn Gln Asp Glu Cys Gln 
        515                 520                 525             


Lys Lys Leu Glu Lys Val Phe Ala Ser Leu Thr Asn Gly Tyr Lys Cys 
    530                 535                 540                 


Asp Lys Cys Lys Ser Gly Thr Ser Arg Ser Lys Lys Lys Trp Ile Trp 
545                 550                 555                 560 


Lys Lys Ser Ser Gly Asn Glu Glu Gly Leu Gln Glu Glu Tyr Ala Asn 
                565                 570                 575     


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Tyr Leu Gly Asn Leu 
            580                 585                 590         


Pro Lys Leu Glu Asn Val Cys Glu Asp Val Lys Asp Ile Asn Phe Asp 
        595                 600                 605             


Thr Lys Glu Lys Phe Leu Ala Gly Cys Leu Ile Val Ser Phe His Glu 
    610                 615                 620                 


Gly Lys Asn Leu Lys Lys Arg Tyr Pro Gln Asn Lys Asn Ser Gly Asn 
625                 630                 635                 640 


Lys Glu Asn Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly 
                645                 650                 655     


Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp 
            660                 665                 670         


Leu Glu Leu Asn Leu Gln Asn Asn Phe Gly Lys Leu Phe Gly Lys Tyr 
        675                 680                 685             


Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp 
705                 710                 715                 720 


Thr Ala Met Lys His Gly Ala Glu Met Asn Ile Thr Thr Cys Asn Ala 
                725                 730                 735     


Asp Gly Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr 
            740                 745                 750         


Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu 
        755                 760                 765             


Asn Phe Cys Glu Gln Arg Gln Ala Lys Val Lys Asp Val Ile Thr Asn 
    770                 775                 780                 


Cys Lys Ser Cys Lys Glu Ser Gly Asn Lys Cys Lys Thr Glu Cys Lys 
785                 790                 795                 800 


Thr Lys Cys Lys Asp Glu Cys Glu Lys Tyr Lys Lys Phe Ile Glu Ala 
                805                 810                 815     


Cys Gly Thr Ala Gly Gly Gly Ile Gly Thr Ala Gly Ser Pro Trp Ser 
            820                 825                 830         


Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys His Ile Glu Asp 
        835                 840                 845             


Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly Thr Ser Ser 
    850                 855                 860                 


Thr Thr Asn Ala Ala Ala Ser Thr Asp Glu Asn Lys Cys Val Gln Ser 
865                 870                 875                 880 


Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr 
                885                 890                 895     


Pro Ser Ser Tyr Leu Ser Asn Val Leu Asp Asp Asn Ile Cys Gly Ala 
            900                 905                 910         


Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Glu Lys 
        915                 920                 925             


Cys Asn Lys Glu Arg Asp Lys Ser Lys Ser Gln Ser Ser Asp Thr Leu 
    930                 935                 940                 


Val Val Val Asn Val Pro Ser Pro Leu Gly Asn Thr Pro Tyr Arg Tyr 
945                 950                 955                 960 


Lys Tyr Ala Cys Gln Cys Lys Ile Pro Thr Asn Glu Glu Thr Cys Asp 
                965                 970                 975     


Asp Arg Lys Glu Tyr Met Asn Gln Trp Ser Cys Gly Ser Ala Arg Thr 
            980                 985                 990         


Met Lys Arg Gly Tyr Lys Asn Asp  Asn Tyr Glu Leu Cys  Lys Tyr Asn 
        995                 1000                 1005             


Gly Val  Asp Val Lys Pro Thr  Thr Val Arg Ser Asn  Ser Ser Lys 
    1010                 1015                 1020             


Leu Asp  Gly Asn Asp Val Thr  Phe Phe Asn Leu Phe  Glu Gln Trp 
    1025                 1030                 1035             


Asn Lys  Glu Ile Gln Tyr Gln  Ile Glu Gln Tyr Met  Thr Asn Ala 
    1040                 1045                 1050             


Asn Ile  Ser Cys Ile Asp Glu  Lys Glu Val Leu Asp  Ser Val Ser 
    1055                 1060                 1065             


Asp Glu  Gly Thr Pro Lys Val  Arg Gly Gly Tyr Glu  Asp Gly Arg 
    1070                 1075                 1080             


Asn Asn  Asn Thr Asp Gln Gly  Thr Asn Cys Lys Glu  Lys Cys Lys 
    1085                 1090                 1095             


Cys Tyr  Lys Leu Trp Ile Glu  Lys Ile Asn Asp Gln  Trp Gly Lys 
    1100                 1105                 1110             


Gln Lys  Asp Asn Tyr Asn Lys  Phe Arg Ser Lys Gln  Ile Tyr Asp 
    1115                 1120                 1125             


Ala Asn  Lys Gly Ser Gln Asn  Lys Lys Val Val Ser  Leu Ser Asn 
    1130                 1135                 1140             


Phe Leu  Phe Phe Ser Cys Trp  Glu Glu Tyr Ile Gln  Lys Tyr Phe 
    1145                 1150                 1155             


Asn Gly  Asp Trp Ser Lys Ile  Lys Asn Ile Gly Ser  Asp Thr Phe 
    1160                 1165                 1170             


Glu Phe  Leu Ile Lys Lys Cys  Gly Asn Asn Ser Ala  His Gly Glu 
    1175                 1180                 1185             


Glu Ile  Phe Asn Glu Lys Leu  Lys Asn Ala Glu Lys  Lys Cys Lys 
    1190                 1195                 1200             


Glu Asn  Glu Ser Thr Asp Thr  Asn Ile Asn Lys Ser  Glu Thr Ser 
    1205                 1210                 1215             


Cys Asp  Leu Asn Ala Thr Asn  Tyr Ile Arg Gly Cys  Gln Ser Lys 
    1220                 1225                 1230             


Thr Tyr  Asp Gly Lys Ile Phe  Pro Gly Lys Gly Gly  Glu Lys Gln 
    1235                 1240                 1245             


Trp Ile  Cys Lys Asp Thr Ile  Ile His Gly Asp Thr  Asn Gly Ala 
    1250                 1255                 1260             


Cys Ile  Pro Pro Arg Thr Gln  Asn Leu Cys Val Gly  Glu Leu Trp 
    1265                 1270                 1275             


Asp Lys  Ser Tyr Gly Gly Arg  Ser Asn Ile Lys Asn  Asp Thr Lys 
    1280                 1285                 1290             


Glu Leu  Leu Lys Glu Lys Ile  Lys Asn Ala Ile His  Lys Glu Thr 
    1295                 1300                 1305             


Glu Leu  Leu Tyr Glu Tyr His  Asp Thr Gly Thr Ala  Ile Ile Ser 
    1310                 1315                 1320             


Lys Asn  Asp Lys Lys Gly Gln  Lys Gly Lys Asn Asp  Pro Asn Gly 
    1325                 1330                 1335             


Leu Pro  Lys Gly Phe Cys His  Ala Val Gln Arg Ser  Phe Ile Asp 
    1340                 1345                 1350             


Tyr Lys  Asn Met Ile Leu Gly  Thr Ser Val Asn Ile  Tyr Glu His 
    1355                 1360                 1365             


Ile Gly  Lys Leu Gln Glu Asp  Ile Lys Lys Ile Ile  Glu Lys Gly 
    1370                 1375                 1380             


Thr Pro  Gln Gln Lys Asp Lys  Ile Gly Gly Val Gly  Ser Ser Thr 
    1385                 1390                 1395             


Glu Asn  Val Asn Ala Trp Trp  Lys Gly Ile Glu Arg  Glu Met Trp 
    1400                 1405                 1410             


Asp Ala  Val Arg Cys Ala Ile  Thr Lys Ile Asn Lys  Lys Asn Asn 
    1415                 1420                 1425             


Asn Ser  Ile Phe Asn Gly Asp  Glu Cys Gly Val Ser  Pro Pro Thr 
    1430                 1435                 1440             


Gly Asn  Asp Glu Asp Gln Ser  Val Ser Trp Phe Lys  Glu Trp Gly 
    1445                 1450                 1455             


Glu Gln  Phe Cys Ile Glu Arg  Leu Arg Tyr Glu Gln  Asn Ile Arg 
    1460                 1465                 1470             


Glu Ala  Cys Thr Ile Asn Gly  Lys Asn Glu Lys Lys  Cys Ile Asn 
    1475                 1480                 1485             


Ser Lys  Ser Gly Gln Gly Asp  Lys Ile Gln Gly Ala  Cys Lys Arg 
    1490                 1495                 1500             


Lys Cys  Glu Lys Tyr Lys Lys  Tyr Ile Ser Glu Lys  Lys Gln Glu 
    1505                 1510                 1515             


Trp Asp  Lys Gln Lys Thr Lys  Tyr Glu Asn Lys Tyr  Val Gly Lys 
    1520                 1525                 1530             


Ser Ala  Ser Asp Leu Leu Lys  Glu Asn Tyr Pro Glu  Cys Ile Ser 
    1535                 1540                 1545             


Ala Asn  Phe Asp Phe Ile Phe  Asn Asp Asn Ile Glu  Tyr Lys Thr 
    1550                 1555                 1560             


Tyr Tyr  Pro Tyr Gly Asp Tyr  Ser Ser Ile Cys Ser  Cys Glu Gln 
    1565                 1570                 1575             


Val Lys  Tyr Tyr Lys Tyr Asn  Asn Ala Glu Lys Lys  Asn Asn Lys 
    1580                 1585                 1590             


Ser Leu  Cys Tyr Glu Lys Asp  Asn Asp Met Thr Trp  Ser Lys Lys 
    1595                 1600                 1605             


Tyr Ile  Lys Lys Leu Glu Asn  Gly Arg Ser Leu Glu  Gly Val Tyr 
    1610                 1615                 1620             


Val Pro  Pro Arg Arg Gln Gln  Leu Cys Leu Tyr Glu  Leu Phe Pro 
    1625                 1630                 1635             


Ile Ile  Ile Lys Asn Glu Glu  Gly Met Glu Lys Ala  Lys Glu Glu 
    1640                 1645                 1650             


Leu Leu  Glu Thr Leu Gln Ile  Val Ala Glu Arg Glu  Ala Tyr Tyr 
    1655                 1660                 1665             


Leu Trp  Lys Gln Tyr Asn Pro  Thr Gly Lys Gly Ile  Asp Asp Ala 
    1670                 1675                 1680             


Asn Lys  Lys Ala Cys Cys Ala  Ile Arg Gly Ser Phe  Tyr Asp Leu 
    1685                 1690                 1695             


Glu Asp  Ile Ile Lys Gly Asn  Asp Leu Val His Asp  Glu Tyr Thr 
    1700                 1705                 1710             


Lys Tyr  Ile Asp Ser Lys Leu  Asn Glu Ile Phe Gly  Ser Ser Asp 
    1715                 1720                 1725             


Thr Asn  Asp Ile Asp Thr Lys  Arg Ala Arg Thr Asp  Trp Trp Glu 
    1730                 1735                 1740             


Asn Glu  Thr Ile Thr Asn Gly  Thr Asp Arg Lys Thr  Ile Arg Gln 
    1745                 1750                 1755             


Leu Val  Trp Asp Ala Met Gln  Ser Gly Val Arg Tyr  Ala Val Glu 
    1760                 1765                 1770             


Glu Lys  Asn Glu Asn Phe Pro  Leu Cys Met Gly Val  Glu His Ile 
    1775                 1780                 1785             


Gly Ile  Ala Lys Pro Gln Phe  Ile Arg Trp Leu Glu  Glu Trp Thr 
    1790                 1795                 1800             


Asn Glu  Phe Cys Glu Lys Tyr  Thr Lys Tyr Phe Glu  Asp Met Lys 
    1805                 1810                 1815             


Ser Lys  Cys Asp Pro Pro Lys  Arg Ala Asp Thr Cys  Gly Asp Asn 
    1820                 1825                 1830             


Ser Asn  Ile Glu Cys Lys Lys  Ala Cys Ala Asn Tyr  Thr Asn Trp 
    1835                 1840                 1845             


Leu Asn  Pro Lys Arg Ile Glu  Trp Asn Gly Met Ser  Asn Tyr Tyr 
    1850                 1855                 1860             


Asn Lys  Ile Tyr Arg Lys Ser  Asn Lys Glu Ser Glu  Gly Gly Lys 
    1865                 1870                 1875             


Asp Tyr  Ser Met Ile Met Ala  Pro Thr Val Ile Asp  Tyr Leu Asn 
    1880                 1885                 1890             


Lys Arg  Cys His Gly Glu Ile  Asn Gly Asn Tyr Ile  Cys Cys Ser 
    1895                 1900                 1905             


Cys Lys  Asn Ile Gly Ala Tyr  Asn Thr Thr Ser Gly  Thr Val Asn 
    1910                 1915                 1920             


Lys Lys  Leu Gln Lys Lys Glu  Thr Glu Cys Glu Glu  Glu Lys Gly 
    1925                 1930                 1935             


Pro Leu  Asp Leu Met Asn Glu  Val Leu Asn Lys Met  Asp Lys Lys 
    1940                 1945                 1950             


Tyr Ser  Ala His Lys Met Lys  Cys Thr Glu Val Tyr  Leu Glu His 
    1955                 1960                 1965             


Val Glu  Glu Gln Leu Asn Glu  Ile Asp Asn Ala Ile  Lys Asp Tyr 
    1970                 1975                 1980             


Lys Leu  Tyr Pro Leu Asp Arg  Cys Phe Asp Asp Gln  Thr Lys Met 
    1985                 1990                 1995             


Lys Val  Cys Asp Leu Ile Ala  Asp Ala Ile Gly Cys  Lys Asp Lys 
    2000                 2005                 2010             


Thr Lys  Leu Asp Glu Leu Asp  Glu Trp Asn Asp Met  Asp Leu Arg 
    2015                 2020                 2025             


Gly Thr  Tyr Asn Lys His Lys  Gly Val Leu Ile Pro  Pro Arg Arg 
    2030                 2035                 2040             


Arg Gln  Leu Cys Phe Ser Arg  Ile Val Arg Gly Pro  Ala Asn Leu 
    2045                 2050                 2055             


Arg Ser  Leu Asn Glu Phe Lys  Glu Glu Ile Leu Lys  Gly Ala Gln 
    2060                 2065                 2070             


Ser Glu  Gly Lys Phe Leu Gly  Asn Tyr Tyr Lys Glu  His Lys Asp 
    2075                 2080                 2085             


Lys Glu  Lys Ala Leu Glu Ala  Met Lys Asn Ser Phe  Tyr Asp Tyr 
    2090                 2095                 2100             


Glu Asp  Ile Ile Lys Gly Thr  Asp Met Leu Thr Asn  Ile Glu Phe 
    2105                 2110                 2115             


Lys Asp  Ile Lys Ile Lys Leu  Asp Arg Leu Leu Glu  Lys Glu Thr 
    2120                 2125                 2130             


Asn Asn  Thr Lys Lys Ala Glu  Asp Trp Trp Lys Thr  Asn Lys Lys 
    2135                 2140                 2145             


Ser Ile  Trp Asn Ala Met Leu  Cys Gly Tyr Lys Lys  Ser Gly Asn 
    2150                 2155                 2160             


Lys Ile  Ile Asp Pro Ser Trp  Cys Thr Ile Pro Thr  Thr Glu Thr 
    2165                 2170                 2175             


Pro Pro  Gln Phe Leu Arg Trp  Ile Lys Glu Trp Gly  Thr Asn Val 
    2180                 2185                 2190             


Cys Ile  Gln Lys Gln Glu His  Lys Glu Tyr Val Lys  Ser Lys Cys 
    2195                 2200                 2205             


Ser Asn  Val Thr Asn Leu Gly  Ala Gln Ala Ser Glu  Ser Asn Asn 
    2210                 2215                 2220             


Cys Thr  Ser Glu Ile Lys Lys  Tyr Gln Glu Trp Ser  Arg Lys Arg 
    2225                 2230                 2235             


Ser Ile  Arg Trp Glu Thr Ile  Ser Lys Arg Tyr Lys  Lys Tyr Lys 
    2240                 2245                 2250             


Arg Met  Asp Ile Leu Lys Asp  Val Lys Glu Pro Asp  Ala Asn Thr 
    2255                 2260                 2265             


Tyr Leu  Arg Glu His Cys Ser  Lys Cys Pro Cys Gly  Phe Asn Asp 
    2270                 2275                 2280             


Met Glu  Glu Met Asn Asn Asn  Glu Asp Asn Glu Lys  Glu Ala Phe 
    2285                 2290                 2295             


Lys Gln  Ile Lys Glu Gln Val  Lys Ile Pro Ala Glu  Leu Glu Asp 
    2300                 2305                 2310             


Val Ile  Tyr Arg Ile Lys His  His Glu Tyr Asp Lys  Gly Asn Asp 
    2315                 2320                 2325             


Tyr Ile  Cys Asn Lys Tyr Lys  Asn Ile His Asp Arg  Met Lys Lys 
    2330                 2335                 2340             


Asn Asn  Gly Asn Phe Val Thr  Asp Asn Phe Val Lys  Lys Ser Trp 
    2345                 2350                 2355             


Glu Ile  Ser Asn Gly Val Leu  Ile Pro Pro Arg Arg  Lys Asn Leu 
    2360                 2365                 2370             


Phe Leu  Tyr Ile Asp Pro Ser  Lys Ile Cys Glu Tyr  Lys Lys Asp 
    2375                 2380                 2385             


Pro Lys  Leu Phe Lys Asp Phe  Ile Tyr Trp Ser Ala  Phe Thr Glu 
    2390                 2395                 2400             


Val Glu  Arg Leu Lys Lys Ala  Tyr Gly Gly Ala Arg  Ala Lys Val 
    2405                 2410                 2415             


Val His  Ala Met Lys Tyr Ser  Phe Thr Asp Ile Gly  Ser Ile Ile 
    2420                 2425                 2430             


Lys Gly  Asp Asp Met Met Glu  Lys Asn Ser Ser Asp  Lys Ile Gly 
    2435                 2440                 2445             


Lys Ile  Leu Gly Asp Thr Asp  Gly Gln Asn Glu Lys  Arg Lys Lys 
    2450                 2455                 2460             


Trp Trp  Asp Met Asn Lys Tyr  His Ile Trp Glu Ser  Met Leu Cys 
    2465                 2470                 2475             


Gly Tyr  Arg Glu Ala Glu Gly  Asp Thr Glu Thr Asn  Glu Asn Cys 
    2480                 2485                 2490             


Arg Phe  Pro Asp Ile Glu Ser  Val Pro Gln Phe Leu  Arg Trp Phe 
    2495                 2500                 2505             


Gln Glu  Trp Ser Glu Asn Phe  Cys Asp Arg Arg Gln  Lys Leu Tyr 
    2510                 2515                 2520             


Asp Lys  Leu Asn Ser Glu Cys  Ile Ser Ala Glu Cys  Thr Asn Gly 
    2525                 2530                 2535             


Ser Val  Asp Asn Ser Lys Cys  Thr His Ala Cys Val  Asn Tyr Lys 
    2540                 2545                 2550             


Asn Tyr  Ile Leu Thr Lys Lys  Thr Glu Tyr Glu Ile  Gln Thr Asn 
    2555                 2560                 2565             


Lys Tyr  Asp Asn Glu Phe Lys  Asn Lys Asn Ser Asn  Asp Lys Asp 
    2570                 2575                 2580             


Ala Pro  Asp Tyr Leu Lys Glu  Lys Cys Asn Asp Asn  Lys Cys Glu 
    2585                 2590                 2595             


Cys Leu  Asn Lys His Ile Asp  Asp Lys Asn Lys Thr  Trp Lys Asn 
    2600                 2605                 2610             


Pro Tyr  Glu Thr Leu Glu Asp  Thr Phe Lys Ser Lys  Cys Asp Cys 
    2615                 2620                 2625             


Pro Lys  Pro Leu Pro Ser Pro  Ile Lys Pro Asp Asp  Leu Pro Pro 
    2630                 2635                 2640             


Gln Ala  Asp Glu Pro Phe 
    2645                 


<210>  3
<211>  1599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3

Met Asp Lys Ser Ser Ile Ala Asn Lys Ile Glu Ala Tyr Leu Gly Ala 
1               5                   10                  15      


Lys Ser Asp Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Arg Lys 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
            100                 105                 110         


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
                165                 170                 175     


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
        195                 200                 205             


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
    210                 215                 220                 


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
225                 230                 235                 240 


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
                245                 250                 255     


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
            260                 265                 270         


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
        275                 280                 285             


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
    290                 295                 300                 


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
305                 310                 315                 320 


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
                325                 330                 335     


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
            340                 345                 350         


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
        355                 360                 365             


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
    370                 375                 380                 


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
385                 390                 395                 400 


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
                405                 410                 415     


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
            420                 425                 430         


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
        435                 440                 445             


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
    450                 455                 460                 


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
465                 470                 475                 480 


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
                485                 490                 495     


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
            500                 505                 510         


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
        515                 520                 525             


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
    530                 535                 540                 


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
545                 550                 555                 560 


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
                565                 570                 575     


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
            580                 585                 590         


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
        595                 600                 605             


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
    610                 615                 620                 


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
625                 630                 635                 640 


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
                645                 650                 655     


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
            660                 665                 670         


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
        675                 680                 685             


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
    690                 695                 700                 


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
705                 710                 715                 720 


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly 
                725                 730                 735     


Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp 
            740                 745                 750         


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
        755                 760                 765             


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys Lys 
    770                 775                 780                 


Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Glu 
785                 790                 795                 800 


Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Asp Cys Lys 
                805                 810                 815     


Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln 
            820                 825                 830         


Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg 
        835                 840                 845             


Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala 
    850                 855                 860                 


Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu 
865                 870                 875                 880 


Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu 
                885                 890                 895     


Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr 
            900                 905                 910         


Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser Lys 
        915                 920                 925             


Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu 
    930                 935                 940                 


Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro 
945                 950                 955                 960 


Thr Asn Glu Glu Thr Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp 
                965                 970                 975     


Ser Cys Gly Ser Ala Arg Thr Met Lys Arg Gly Tyr Lys Asn Asp Asn 
            980                 985                 990         


Tyr Glu Leu Cys Lys Tyr Asn Gly  Val Asp Val Lys Pro  Thr Thr Val 
        995                 1000                 1005             


Arg Ser  Asn Ser Ser Lys Leu  Asp Asp Lys Asp Val  Thr Phe Phe 
    1010                 1015                 1020             


Asn Leu  Phe Glu Gln Trp Asn  Lys Glu Ile Gln Tyr  Gln Ile Glu 
    1025                 1030                 1035             


Gln Tyr  Met Thr Asn Thr Lys  Ile Ser Cys Asn Asn  Glu Lys Asn 
    1040                 1045                 1050             


Val Leu  Ser Arg Val Ser Asp  Glu Ala Ala Gln Pro  Lys Phe Ser 
    1055                 1060                 1065             


Asp Asn  Glu Arg Asp Arg Asn  Ser Ile Thr His Glu  Asp Lys Asn 
    1070                 1075                 1080             


Cys Lys  Glu Lys Cys Lys Cys  Tyr Ser Leu Trp Ile  Glu Lys Ile 
    1085                 1090                 1095             


Asn Asp  Gln Trp Asp Lys Gln  Lys Asp Asn Tyr Asn  Lys Phe Gln 
    1100                 1105                 1110             


Arg Lys  Gln Ile Tyr Asp Ala  Asn Lys Gly Ser Gln  Asn Lys Lys 
    1115                 1120                 1125             


Val Val  Ser Leu Ser Asn Phe  Leu Phe Phe Ser Cys  Trp Glu Glu 
    1130                 1135                 1140             


Tyr Ile  Gln Lys Tyr Phe Asn  Gly Asp Trp Ser Lys  Ile Lys Asn 
    1145                 1150                 1155             


Ile Gly  Ser Asp Thr Phe Glu  Phe Leu Ile Lys Lys  Cys Gly Asn 
    1160                 1165                 1170             


Asp Ser  Gly Asp Gly Glu Thr  Ile Phe Ser Glu Lys  Leu Asn Asn 
    1175                 1180                 1185             


Ala Glu  Lys Lys Cys Lys Glu  Asn Glu Ser Thr Asn  Asn Lys Met 
    1190                 1195                 1200             


Lys Ser  Ser Glu Thr Ser Gly  Ser Gly Ser Gly Ala  Glu Lys Lys 
    1205                 1210                 1215             


Asn Asn  Lys Ser Leu Cys His  Glu Lys Gly Asn Asp  Arg Thr Trp 
    1220                 1225                 1230             


Ser Lys  Lys Tyr Ile Lys Lys  Leu Glu Asn Gly Arg  Thr Leu Glu 
    1235                 1240                 1245             


Gly Val  Tyr Val Pro Pro Arg  Arg Gln Gln Leu Cys  Leu Tyr Glu 
    1250                 1255                 1260             


Leu Phe  Pro Ile Ile Ile Lys  Asn Lys Asn Asp Ile  Thr Asn Ala 
    1265                 1270                 1275             


Lys Lys  Glu Leu Leu Glu Thr  Leu Gln Ile Val Ala  Glu Arg Glu 
    1280                 1285                 1290             


Ala Tyr  Tyr Leu Trp Lys Gln  Tyr His Ala His Asn  Asp Thr Thr 
    1295                 1300                 1305             


Tyr Leu  Ala His Lys Lys Ala  Cys Cys Ala Ile Arg  Gly Ser Phe 
    1310                 1315                 1320             


Tyr Asp  Leu Glu Asp Ile Ile  Lys Gly Asn Asp Leu  Val His Asp 
    1325                 1330                 1335             


Glu Tyr  Thr Lys Tyr Ile Asp  Ser Lys Leu Asn Glu  Ile Phe Asp 
    1340                 1345                 1350             


Ser Ser  Asn Lys Asn Asp Ile  Glu Thr Lys Arg Ala  Arg Thr Asp 
    1355                 1360                 1365             


Trp Trp  Glu Asn Glu Ala Ile  Ala Val Pro Asn Ile  Thr Gly Ala 
    1370                 1375                 1380             


Asn Lys  Ser Asp Pro Lys Thr  Ile Arg Gln Leu Val  Trp Asp Ala 
    1385                 1390                 1395             


Met Gln  Ser Gly Val Arg Lys  Ala Ile Asp Glu Glu  Lys Glu Lys 
    1400                 1405                 1410             


Lys Lys  Pro Asn Glu Asn Phe  Pro Pro Cys Met Gly  Val Gln His 
    1415                 1420                 1425             


Ile Gly  Ile Ala Lys Pro Gln  Phe Ile Arg Trp Leu  Glu Glu Trp 
    1430                 1435                 1440             


Thr Asn  Glu Phe Cys Glu Lys  Tyr Thr Lys Tyr Phe  Glu Asp Met 
    1445                 1450                 1455             


Lys Ser  Asn Cys Asn Leu Arg  Lys Gly Ala Asp Asp  Cys Asp Asp 
    1460                 1465                 1470             


Asn Ser  Asn Ile Glu Cys Lys  Lys Ala Cys Ala Asn  Tyr Thr Asn 
    1475                 1480                 1485             


Trp Leu  Asn Pro Lys Arg Ile  Glu Trp Asn Gly Met  Ser Asn Tyr 
    1490                 1495                 1500             


Tyr Asn  Lys Ile Tyr Arg Lys  Ser Asn Lys Glu Ser  Glu Asp Gly 
    1505                 1510                 1515             


Lys Asp  Tyr Ser Met Ile Met  Glu Pro Thr Val Ile  Asp Tyr Leu 
    1520                 1525                 1530             


Asn Lys  Arg Cys Asn Gly Glu  Ile Asn Gly Asn Tyr  Ile Cys Cys 
    1535                 1540                 1545             


Ser Cys  Lys Asn Ile Gly Glu  Asn Ser Thr Ser Gly  Thr Val Asn 
    1550                 1555                 1560             


Lys Lys  Leu Gln Lys Lys Glu  Thr Gln Cys Glu Asp  Asn Lys Gly 
    1565                 1570                 1575             


Pro Leu  Asp Leu Met Asn Lys  Val Leu Asn Lys Met  Asp Pro Lys 
    1580                 1585                 1590             


Tyr Ser  Glu His Lys Met 
    1595                 


<210>  4
<211>  1596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4

Met Asp Ser Thr Ser Thr Ile Ala Asn Lys Ile Glu Glu Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asp Asp Ser Lys Ile Asp Glu Leu Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Asp Pro Cys Glu Lys Lys Leu Pro Pro Tyr Asp Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Gly Lys Pro Glu Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Glu Arg Leu Cys Thr Tyr Asn Leu Glu Asn 
            100                 105                 110         


Leu Lys Phe Asp Lys Ile Arg Asp Asn Asn Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Lys Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Lys Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu 
            180                 185                 190         


Asn Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Lys Tyr Thr 
        195                 200                 205             


Lys Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly 
225                 230                 235                 240 


Trp Arg Thr Ser Gly Lys Ser Asp Arg Lys Lys Asn Phe Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Lys Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr 
        275                 280                 285             


Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser 
305                 310                 315                 320 


Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp 
                325                 330                 335     


Lys Thr Glu Trp Glu Asn Gln Glu Asn Lys Tyr Lys Asp Leu Tyr Glu 
            340                 345                 350         


Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp 
        355                 360                 365             


Tyr Val Lys Asp Phe Phe Glu Lys Leu Glu Ala Asn Tyr Ser Ser Leu 
    370                 375                 380                 


Glu Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys 
385                 390                 395                 400 


Leu Ser Phe Ile Leu Asn Pro Ser Asp Ala Asn Asn Pro Ser Gly Glu 
                405                 410                 415     


Thr Ala Asn His Asn Asp Glu Ala Cys Asn Cys Asn Glu Ser Gly Ile 
            420                 425                 430         


Ser Ser Val Gly Gln Ala Gln Thr Ser Gly Pro Ser Ser Asn Lys Thr 
        435                 440                 445             


Cys Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Glu Cys Lys 
    450                 455                 460                 


Asp Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Lys Ile Cys 
465                 470                 475                 480 


Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys Gln 
                485                 490                 495     


Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg Gly 
            500                 505                 510         


Ser Ser Ser Asn Asp Ser Cys Asp Asn Lys Asn Gln Asp Glu Cys Gln 
        515                 520                 525             


Lys Lys Leu Glu Lys Val Phe Ala Ser Leu Thr Asn Gly Tyr Lys Cys 
    530                 535                 540                 


Asp Lys Cys Lys Ser Gly Thr Ser Arg Ser Lys Lys Lys Trp Ile Trp 
545                 550                 555                 560 


Lys Lys Ser Ser Gly Asn Glu Glu Gly Leu Gln Glu Glu Tyr Ala Asn 
                565                 570                 575     


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Tyr Leu Gly Asn Leu 
            580                 585                 590         


Pro Lys Leu Glu Asn Val Cys Glu Asp Val Lys Asp Ile Asn Phe Asp 
        595                 600                 605             


Thr Lys Glu Lys Phe Leu Ala Gly Cys Leu Ile Val Ser Phe His Glu 
    610                 615                 620                 


Gly Lys Asn Leu Lys Lys Arg Tyr Pro Gln Asn Lys Asn Ser Gly Asn 
625                 630                 635                 640 


Lys Glu Asn Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly 
                645                 650                 655     


Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp 
            660                 665                 670         


Leu Glu Leu Asn Leu Gln Asn Asn Phe Gly Lys Leu Phe Gly Lys Tyr 
        675                 680                 685             


Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp 
705                 710                 715                 720 


Thr Ala Met Lys His Gly Ala Glu Met Asn Ile Thr Thr Cys Asn Ala 
                725                 730                 735     


Asp Gly Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr 
            740                 745                 750         


Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu 
        755                 760                 765             


Asn Phe Cys Glu Gln Arg Gln Ala Lys Val Lys Asp Val Ile Thr Asn 
    770                 775                 780                 


Cys Lys Ser Cys Lys Glu Ser Gly Asn Lys Cys Lys Thr Glu Cys Lys 
785                 790                 795                 800 


Thr Lys Cys Lys Asp Glu Cys Glu Lys Tyr Lys Lys Phe Ile Glu Ala 
                805                 810                 815     


Cys Gly Thr Ala Gly Gly Gly Ile Gly Thr Ala Gly Ser Pro Trp Ser 
            820                 825                 830         


Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys His Ile Glu Asp 
        835                 840                 845             


Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly Thr Ser Ser 
    850                 855                 860                 


Thr Thr Asn Ala Ala Ala Ser Thr Asp Glu Asn Lys Cys Val Gln Ser 
865                 870                 875                 880 


Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr 
                885                 890                 895     


Pro Ser Ser Tyr Leu Ser Asn Val Leu Asp Asp Asn Ile Cys Gly Ala 
            900                 905                 910         


Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Glu Lys 
        915                 920                 925             


Cys Asn Lys Glu Arg Asp Lys Ser Lys Ser Gln Ser Ser Asp Thr Leu 
    930                 935                 940                 


Val Val Val Asn Val Pro Ser Pro Leu Gly Asn Thr Pro Tyr Arg Tyr 
945                 950                 955                 960 


Lys Tyr Ala Cys Gln Cys Lys Ile Pro Thr Asn Glu Glu Thr Cys Asp 
                965                 970                 975     


Asp Arg Lys Glu Tyr Met Asn Gln Trp Ser Cys Gly Ser Ala Arg Thr 
            980                 985                 990         


Met Lys Arg Gly Tyr Lys Asn Asp  Asn Tyr Glu Leu Cys  Lys Tyr Asn 
        995                 1000                 1005             


Gly Val  Asp Val Lys Pro Thr  Thr Val Arg Ser Asn  Ser Ser Lys 
    1010                 1015                 1020             


Leu Asp  Gly Asn Asp Val Thr  Phe Phe Asn Leu Phe  Glu Gln Trp 
    1025                 1030                 1035             


Asn Lys  Glu Ile Gln Tyr Gln  Ile Glu Gln Tyr Met  Thr Asn Ala 
    1040                 1045                 1050             


Asn Ile  Ser Cys Ile Asp Glu  Lys Glu Val Leu Asp  Ser Val Ser 
    1055                 1060                 1065             


Asp Glu  Gly Thr Pro Lys Val  Arg Gly Gly Tyr Glu  Asp Gly Arg 
    1070                 1075                 1080             


Asn Asn  Asn Thr Asp Gln Gly  Thr Asn Cys Lys Glu  Lys Cys Lys 
    1085                 1090                 1095             


Cys Tyr  Lys Leu Trp Ile Glu  Lys Ile Asn Asp Gln  Trp Gly Lys 
    1100                 1105                 1110             


Gln Lys  Asp Asn Tyr Asn Lys  Phe Arg Ser Lys Gln  Ile Tyr Asp 
    1115                 1120                 1125             


Ala Asn  Lys Gly Ser Gln Asn  Lys Lys Val Val Ser  Leu Ser Asn 
    1130                 1135                 1140             


Phe Leu  Phe Phe Ser Cys Trp  Glu Glu Tyr Ile Gln  Lys Tyr Phe 
    1145                 1150                 1155             


Asn Gly  Asp Trp Ser Lys Ile  Lys Asn Ile Gly Ser  Asp Thr Phe 
    1160                 1165                 1170             


Glu Phe  Leu Ile Lys Lys Cys  Gly Asn Asn Ser Ala  His Gly Glu 
    1175                 1180                 1185             


Glu Ile  Phe Asn Glu Lys Leu  Lys Asn Ala Glu Lys  Lys Cys Lys 
    1190                 1195                 1200             


Glu Asn  Glu Ser Thr Asp Thr  Asn Ile Asn Lys Ser  Glu Thr Ser 
    1205                 1210                 1215             


Gly Ser  Gly Ser Gly Ala Glu  Lys Lys Asn Asn Lys  Ser Leu Cys 
    1220                 1225                 1230             


Tyr Glu  Lys Asp Asn Asp Met  Thr Trp Ser Lys Lys  Tyr Ile Lys 
    1235                 1240                 1245             


Lys Leu  Glu Asn Gly Arg Ser  Leu Glu Gly Val Tyr  Val Pro Pro 
    1250                 1255                 1260             


Arg Arg  Gln Gln Leu Cys Leu  Tyr Glu Leu Phe Pro  Ile Ile Ile 
    1265                 1270                 1275             


Lys Asn  Glu Glu Gly Met Glu  Lys Ala Lys Glu Glu  Leu Leu Glu 
    1280                 1285                 1290             


Thr Leu  Gln Ile Val Ala Glu  Arg Glu Ala Tyr Tyr  Leu Trp Lys 
    1295                 1300                 1305             


Gln Tyr  Asn Pro Thr Gly Lys  Gly Ile Asp Asp Ala  Asn Lys Lys 
    1310                 1315                 1320             


Ala Cys  Cys Ala Ile Arg Gly  Ser Phe Tyr Asp Leu  Glu Asp Ile 
    1325                 1330                 1335             


Ile Lys  Gly Asn Asp Leu Val  His Asp Glu Tyr Thr  Lys Tyr Ile 
    1340                 1345                 1350             


Asp Ser  Lys Leu Asn Glu Ile  Phe Gly Ser Ser Asp  Thr Asn Asp 
    1355                 1360                 1365             


Ile Asp  Thr Lys Arg Ala Arg  Thr Asp Trp Trp Glu  Asn Glu Thr 
    1370                 1375                 1380             


Ile Thr  Asn Gly Thr Asp Arg  Lys Thr Ile Arg Gln  Leu Val Trp 
    1385                 1390                 1395             


Asp Ala  Met Gln Ser Gly Val  Arg Tyr Ala Val Glu  Glu Lys Asn 
    1400                 1405                 1410             


Glu Asn  Phe Pro Leu Cys Met  Gly Val Glu His Ile  Gly Ile Ala 
    1415                 1420                 1425             


Lys Pro  Gln Phe Ile Arg Trp  Leu Glu Glu Trp Thr  Asn Glu Phe 
    1430                 1435                 1440             


Cys Glu  Lys Tyr Thr Lys Tyr  Phe Glu Asp Met Lys  Ser Lys Cys 
    1445                 1450                 1455             


Asp Pro  Pro Lys Arg Ala Asp  Thr Cys Gly Asp Asn  Ser Asn Ile 
    1460                 1465                 1470             


Glu Cys  Lys Lys Ala Cys Ala  Asn Tyr Thr Asn Trp  Leu Asn Pro 
    1475                 1480                 1485             


Lys Arg  Ile Glu Trp Asn Gly  Met Ser Asn Tyr Tyr  Asn Lys Ile 
    1490                 1495                 1500             


Tyr Arg  Lys Ser Asn Lys Glu  Ser Glu Gly Gly Lys  Asp Tyr Ser 
    1505                 1510                 1515             


Met Ile  Met Ala Pro Thr Val  Ile Asp Tyr Leu Asn  Lys Arg Cys 
    1520                 1525                 1530             


His Gly  Glu Ile Asn Gly Asn  Tyr Ile Cys Cys Ser  Cys Lys Asn 
    1535                 1540                 1545             


Ile Gly  Ala Tyr Asn Thr Thr  Ser Gly Thr Val Asn  Lys Lys Leu 
    1550                 1555                 1560             


Gln Lys  Lys Glu Thr Glu Cys  Glu Glu Glu Lys Gly  Pro Leu Asp 
    1565                 1570                 1575             


Leu Met  Asn Glu Val Leu Asn  Lys Met Asp Lys Lys  Tyr Ser Ala 
    1580                 1585                 1590             


His Lys  Met 
    1595     


<210>  5
<211>  1951
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5

Met Asp Lys Ser Ser Ile Ala Asn Lys Ile Glu Ala Tyr Leu Gly Ala 
1               5                   10                  15      


Lys Ser Asp Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Arg Lys 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
            100                 105                 110         


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
                165                 170                 175     


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
        195                 200                 205             


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
    210                 215                 220                 


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
225                 230                 235                 240 


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
                245                 250                 255     


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
            260                 265                 270         


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
        275                 280                 285             


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
    290                 295                 300                 


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
305                 310                 315                 320 


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
                325                 330                 335     


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
            340                 345                 350         


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
        355                 360                 365             


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
    370                 375                 380                 


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
385                 390                 395                 400 


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
                405                 410                 415     


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
            420                 425                 430         


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
        435                 440                 445             


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
    450                 455                 460                 


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
465                 470                 475                 480 


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
                485                 490                 495     


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
            500                 505                 510         


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
        515                 520                 525             


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
    530                 535                 540                 


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
545                 550                 555                 560 


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
                565                 570                 575     


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
            580                 585                 590         


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
        595                 600                 605             


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
    610                 615                 620                 


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
625                 630                 635                 640 


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
                645                 650                 655     


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
            660                 665                 670         


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
        675                 680                 685             


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
    690                 695                 700                 


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
705                 710                 715                 720 


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly 
                725                 730                 735     


Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp 
            740                 745                 750         


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
        755                 760                 765             


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys Lys 
    770                 775                 780                 


Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Glu 
785                 790                 795                 800 


Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Asp Cys Lys 
                805                 810                 815     


Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln 
            820                 825                 830         


Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg 
        835                 840                 845             


Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala 
    850                 855                 860                 


Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu 
865                 870                 875                 880 


Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu 
                885                 890                 895     


Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr 
            900                 905                 910         


Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser Lys 
        915                 920                 925             


Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu 
    930                 935                 940                 


Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro 
945                 950                 955                 960 


Thr Asn Glu Glu Thr Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp 
                965                 970                 975     


Ser Cys Gly Ser Ala Arg Thr Met Lys Arg Gly Tyr Lys Asn Asp Asn 
            980                 985                 990         


Tyr Glu Leu Cys Lys Tyr Asn Gly  Val Asp Val Lys Pro  Thr Thr Val 
        995                 1000                 1005             


Arg Ser  Asn Ser Ser Lys Leu  Asp Asp Lys Asp Val  Thr Phe Phe 
    1010                 1015                 1020             


Asn Leu  Phe Glu Gln Trp Asn  Lys Glu Ile Gln Tyr  Gln Ile Glu 
    1025                 1030                 1035             


Gln Tyr  Met Thr Asn Thr Lys  Ile Ser Cys Asn Asn  Glu Lys Asn 
    1040                 1045                 1050             


Val Leu  Ser Arg Val Ser Asp  Glu Ala Ala Gln Pro  Lys Phe Ser 
    1055                 1060                 1065             


Asp Asn  Glu Arg Asp Arg Asn  Ser Ile Thr His Glu  Asp Lys Asn 
    1070                 1075                 1080             


Cys Lys  Glu Lys Cys Lys Cys  Tyr Ser Leu Trp Ile  Glu Lys Ile 
    1085                 1090                 1095             


Asn Asp  Gln Trp Asp Lys Gln  Lys Asp Asn Tyr Asn  Lys Phe Gln 
    1100                 1105                 1110             


Arg Lys  Gln Ile Tyr Asp Ala  Asn Lys Gly Ser Gln  Asn Lys Lys 
    1115                 1120                 1125             


Val Val  Ser Leu Ser Asn Phe  Leu Phe Phe Ser Cys  Trp Glu Glu 
    1130                 1135                 1140             


Tyr Ile  Gln Lys Tyr Phe Asn  Gly Asp Trp Ser Lys  Ile Lys Asn 
    1145                 1150                 1155             


Ile Gly  Ser Asp Thr Phe Glu  Phe Leu Ile Lys Lys  Cys Gly Asn 
    1160                 1165                 1170             


Asp Ser  Gly Asp Gly Glu Thr  Ile Phe Ser Glu Lys  Leu Asn Asn 
    1175                 1180                 1185             


Ala Glu  Lys Lys Cys Lys Glu  Asn Glu Ser Thr Asn  Asn Lys Met 
    1190                 1195                 1200             


Lys Ser  Ser Glu Thr Ser Cys  Asp Cys Ser Glu Pro  Ile Tyr Ile 
    1205                 1210                 1215             


Arg Gly  Cys Gln Pro Lys Ile  Tyr Asp Gly Lys Ile  Phe Pro Gly 
    1220                 1225                 1230             


Lys Gly  Gly Glu Lys Gln Trp  Ile Cys Lys Asp Thr  Ile Ile His 
    1235                 1240                 1245             


Gly Asp  Thr Asn Gly Ala Cys  Ile Pro Pro Arg Thr  Gln Asn Leu 
    1250                 1255                 1260             


Cys Val  Gly Glu Leu Trp Asp  Lys Arg Tyr Gly Gly  Arg Ser Asn 
    1265                 1270                 1275             


Ile Lys  Asn Asp Thr Lys Glu  Ser Leu Lys Gln Lys  Ile Lys Asn 
    1280                 1285                 1290             


Ala Ile  Gln Lys Glu Thr Glu  Leu Leu Tyr Glu Tyr  His Asp Lys 
    1295                 1300                 1305             


Gly Thr  Ala Ile Ile Ser Arg  Asn Pro Met Lys Gly  Gln Lys Glu 
    1310                 1315                 1320             


Lys Glu  Glu Lys Asn Asn Asp  Ser Asn Gly Leu Pro  Lys Gly Phe 
    1325                 1330                 1335             


Cys His  Ala Val Gln Arg Ser  Phe Ile Asp Tyr Lys  Asn Met Ile 
    1340                 1345                 1350             


Leu Gly  Thr Ser Val Asn Ile  Tyr Glu Tyr Ile Gly  Lys Leu Gln 
    1355                 1360                 1365             


Glu Asp  Ile Lys Lys Ile Ile  Glu Lys Gly Thr Thr  Lys Gln Asn 
    1370                 1375                 1380             


Gly Lys  Thr Val Gly Ser Gly  Ala Glu Asn Val Asn  Ala Trp Trp 
    1385                 1390                 1395             


Lys Gly  Ile Glu Gly Glu Met  Trp Asp Ala Val Arg  Cys Ala Ile 
    1400                 1405                 1410             


Thr Lys  Ile Asn Lys Lys Gln  Lys Lys Asn Gly Thr  Phe Ser Ile 
    1415                 1420                 1425             


Asp Glu  Cys Gly Ile Phe Pro  Pro Thr Gly Asn Asp  Glu Asp Gln 
    1430                 1435                 1440             


Ser Val  Ser Trp Phe Lys Glu  Trp Ser Glu Gln Phe  Cys Ile Glu 
    1445                 1450                 1455             


Arg Leu  Gln Tyr Glu Lys Asn  Ile Arg Asp Ala Cys  Thr Asn Asn 
    1460                 1465                 1470             


Gly Gln  Gly Asp Lys Ile Gln  Gly Asp Cys Lys Arg  Lys Cys Glu 
    1475                 1480                 1485             


Glu Tyr  Lys Lys Tyr Ile Ser  Glu Lys Lys Gln Glu  Trp Asp Lys 
    1490                 1495                 1500             


Gln Lys  Thr Lys Tyr Glu Asn  Lys Tyr Val Gly Lys  Ser Ala Ser 
    1505                 1510                 1515             


Asp Leu  Leu Lys Glu Asn Tyr  Pro Glu Cys Ile Ser  Ala Asn Phe 
    1520                 1525                 1530             


Asp Phe  Ile Phe Asn Asp Asn  Ile Glu Tyr Lys Thr  Tyr Tyr Pro 
    1535                 1540                 1545             


Tyr Gly  Asp Tyr Ser Ser Ile  Cys Ser Cys Glu Gln  Val Lys Tyr 
    1550                 1555                 1560             


Tyr Glu  Tyr Asn Asn Ala Glu  Lys Lys Asn Asn Lys  Ser Leu Cys 
    1565                 1570                 1575             


His Glu  Lys Gly Asn Asp Arg  Thr Trp Ser Lys Lys  Tyr Ile Lys 
    1580                 1585                 1590             


Lys Leu  Glu Asn Gly Arg Thr  Leu Glu Gly Val Tyr  Val Pro Pro 
    1595                 1600                 1605             


Arg Arg  Gln Gln Leu Cys Leu  Tyr Glu Leu Phe Pro  Ile Ile Ile 
    1610                 1615                 1620             


Lys Asn  Lys Asn Asp Ile Thr  Asn Ala Lys Lys Glu  Leu Leu Glu 
    1625                 1630                 1635             


Thr Leu  Gln Ile Val Ala Glu  Arg Glu Ala Tyr Tyr  Leu Trp Lys 
    1640                 1645                 1650             


Gln Tyr  His Ala His Asn Asp  Thr Thr Tyr Leu Ala  His Lys Lys 
    1655                 1660                 1665             


Ala Cys  Cys Ala Ile Arg Gly  Ser Phe Tyr Asp Leu  Glu Asp Ile 
    1670                 1675                 1680             


Ile Lys  Gly Asn Asp Leu Val  His Asp Glu Tyr Thr  Lys Tyr Ile 
    1685                 1690                 1695             


Asp Ser  Lys Leu Asn Glu Ile  Phe Asp Ser Ser Asn  Lys Asn Asp 
    1700                 1705                 1710             


Ile Glu  Thr Lys Arg Ala Arg  Thr Asp Trp Trp Glu  Asn Glu Ala 
    1715                 1720                 1725             


Ile Ala  Val Pro Asn Ile Thr  Gly Ala Asn Lys Ser  Asp Pro Lys 
    1730                 1735                 1740             


Thr Ile  Arg Gln Leu Val Trp  Asp Ala Met Gln Ser  Gly Val Arg 
    1745                 1750                 1755             


Lys Ala  Ile Asp Glu Glu Lys  Glu Lys Lys Lys Pro  Asn Glu Asn 
    1760                 1765                 1770             


Phe Pro  Pro Cys Met Gly Val  Gln His Ile Gly Ile  Ala Lys Pro 
    1775                 1780                 1785             


Gln Phe  Ile Arg Trp Leu Glu  Glu Trp Thr Asn Glu  Phe Cys Glu 
    1790                 1795                 1800             


Lys Tyr  Thr Lys Tyr Phe Glu  Asp Met Lys Ser Asn  Cys Asn Leu 
    1805                 1810                 1815             


Arg Lys  Gly Ala Asp Asp Cys  Asp Asp Asn Ser Asn  Ile Glu Cys 
    1820                 1825                 1830             


Lys Lys  Ala Cys Ala Asn Tyr  Thr Asn Trp Leu Asn  Pro Lys Arg 
    1835                 1840                 1845             


Ile Glu  Trp Asn Gly Met Ser  Asn Tyr Tyr Asn Lys  Ile Tyr Arg 
    1850                 1855                 1860             


Lys Ser  Asn Lys Glu Ser Glu  Asp Gly Lys Asp Tyr  Ser Met Ile 
    1865                 1870                 1875             


Met Glu  Pro Thr Val Ile Asp  Tyr Leu Asn Lys Arg  Cys Asn Gly 
    1880                 1885                 1890             


Glu Ile  Asn Gly Asn Tyr Ile  Cys Cys Ser Cys Lys  Asn Ile Gly 
    1895                 1900                 1905             


Glu Asn  Ser Thr Ser Gly Thr  Val Asn Lys Lys Leu  Gln Lys Lys 
    1910                 1915                 1920             


Glu Thr  Gln Cys Glu Asp Asn  Lys Gly Pro Leu Asp  Leu Met Asn 
    1925                 1930                 1935             


Lys Val  Leu Asn Lys Met Asp  Pro Lys Tyr Ser Glu  His 
    1940                 1945                 1950     


<210>  6
<211>  1957
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6

Met Asp Ser Thr Ser Thr Ile Ala Asn Lys Ile Glu Glu Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asp Asp Ser Lys Ile Asp Glu Leu Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Asp Pro Cys Glu Lys Lys Leu Pro Pro Tyr Asp Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Gly Lys Pro Glu Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Glu Arg Leu Cys Thr Tyr Asn Leu Glu Asn 
            100                 105                 110         


Leu Lys Phe Asp Lys Ile Arg Asp Asn Asn Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Lys Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Lys Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu 
            180                 185                 190         


Asn Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Lys Tyr Thr 
        195                 200                 205             


Lys Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly 
225                 230                 235                 240 


Trp Arg Thr Ser Gly Lys Ser Asp Arg Lys Lys Asn Phe Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Lys Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr 
        275                 280                 285             


Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser 
305                 310                 315                 320 


Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp 
                325                 330                 335     


Lys Thr Glu Trp Glu Asn Gln Glu Asn Lys Tyr Lys Asp Leu Tyr Glu 
            340                 345                 350         


Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp 
        355                 360                 365             


Tyr Val Lys Asp Phe Phe Glu Lys Leu Glu Ala Asn Tyr Ser Ser Leu 
    370                 375                 380                 


Glu Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys 
385                 390                 395                 400 


Leu Ser Phe Ile Leu Asn Pro Ser Asp Ala Asn Asn Pro Ser Gly Glu 
                405                 410                 415     


Thr Ala Asn His Asn Asp Glu Ala Cys Asn Cys Asn Glu Ser Gly Ile 
            420                 425                 430         


Ser Ser Val Gly Gln Ala Gln Thr Ser Gly Pro Ser Ser Asn Lys Thr 
        435                 440                 445             


Cys Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Glu Cys Lys 
    450                 455                 460                 


Asp Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Lys Ile Cys 
465                 470                 475                 480 


Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys Gln 
                485                 490                 495     


Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg Gly 
            500                 505                 510         


Ser Ser Ser Asn Asp Ser Cys Asp Asn Lys Asn Gln Asp Glu Cys Gln 
        515                 520                 525             


Lys Lys Leu Glu Lys Val Phe Ala Ser Leu Thr Asn Gly Tyr Lys Cys 
    530                 535                 540                 


Asp Lys Cys Lys Ser Gly Thr Ser Arg Ser Lys Lys Lys Trp Ile Trp 
545                 550                 555                 560 


Lys Lys Ser Ser Gly Asn Glu Glu Gly Leu Gln Glu Glu Tyr Ala Asn 
                565                 570                 575     


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Tyr Leu Gly Asn Leu 
            580                 585                 590         


Pro Lys Leu Glu Asn Val Cys Glu Asp Val Lys Asp Ile Asn Phe Asp 
        595                 600                 605             


Thr Lys Glu Lys Phe Leu Ala Gly Cys Leu Ile Val Ser Phe His Glu 
    610                 615                 620                 


Gly Lys Asn Leu Lys Lys Arg Tyr Pro Gln Asn Lys Asn Ser Gly Asn 
625                 630                 635                 640 


Lys Glu Asn Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly 
                645                 650                 655     


Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp 
            660                 665                 670         


Leu Glu Leu Asn Leu Gln Asn Asn Phe Gly Lys Leu Phe Gly Lys Tyr 
        675                 680                 685             


Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp 
705                 710                 715                 720 


Thr Ala Met Lys His Gly Ala Glu Met Asn Ile Thr Thr Cys Asn Ala 
                725                 730                 735     


Asp Gly Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr 
            740                 745                 750         


Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu 
        755                 760                 765             


Asn Phe Cys Glu Gln Arg Gln Ala Lys Val Lys Asp Val Ile Thr Asn 
    770                 775                 780                 


Cys Lys Ser Cys Lys Glu Ser Gly Asn Lys Cys Lys Thr Glu Cys Lys 
785                 790                 795                 800 


Thr Lys Cys Lys Asp Glu Cys Glu Lys Tyr Lys Lys Phe Ile Glu Ala 
                805                 810                 815     


Cys Gly Thr Ala Gly Gly Gly Ile Gly Thr Ala Gly Ser Pro Trp Ser 
            820                 825                 830         


Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys His Ile Glu Asp 
        835                 840                 845             


Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly Thr Ser Ser 
    850                 855                 860                 


Thr Thr Asn Ala Ala Ala Ser Thr Asp Glu Asn Lys Cys Val Gln Ser 
865                 870                 875                 880 


Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr 
                885                 890                 895     


Pro Ser Ser Tyr Leu Ser Asn Val Leu Asp Asp Asn Ile Cys Gly Ala 
            900                 905                 910         


Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Glu Lys 
        915                 920                 925             


Cys Asn Lys Glu Arg Asp Lys Ser Lys Ser Gln Ser Ser Asp Thr Leu 
    930                 935                 940                 


Val Val Val Asn Val Pro Ser Pro Leu Gly Asn Thr Pro Tyr Arg Tyr 
945                 950                 955                 960 


Lys Tyr Ala Cys Gln Cys Lys Ile Pro Thr Asn Glu Glu Thr Cys Asp 
                965                 970                 975     


Asp Arg Lys Glu Tyr Met Asn Gln Trp Ser Cys Gly Ser Ala Arg Thr 
            980                 985                 990         


Met Lys Arg Gly Tyr Lys Asn Asp  Asn Tyr Glu Leu Cys  Lys Tyr Asn 
        995                 1000                 1005             


Gly Val  Asp Val Lys Pro Thr  Thr Val Arg Ser Asn  Ser Ser Lys 
    1010                 1015                 1020             


Leu Asp  Gly Asn Asp Val Thr  Phe Phe Asn Leu Phe  Glu Gln Trp 
    1025                 1030                 1035             


Asn Lys  Glu Ile Gln Tyr Gln  Ile Glu Gln Tyr Met  Thr Asn Ala 
    1040                 1045                 1050             


Asn Ile  Ser Cys Ile Asp Glu  Lys Glu Val Leu Asp  Ser Val Ser 
    1055                 1060                 1065             


Asp Glu  Gly Thr Pro Lys Val  Arg Gly Gly Tyr Glu  Asp Gly Arg 
    1070                 1075                 1080             


Asn Asn  Asn Thr Asp Gln Gly  Thr Asn Cys Lys Glu  Lys Cys Lys 
    1085                 1090                 1095             


Cys Tyr  Lys Leu Trp Ile Glu  Lys Ile Asn Asp Gln  Trp Gly Lys 
    1100                 1105                 1110             


Gln Lys  Asp Asn Tyr Asn Lys  Phe Arg Ser Lys Gln  Ile Tyr Asp 
    1115                 1120                 1125             


Ala Asn  Lys Gly Ser Gln Asn  Lys Lys Val Val Ser  Leu Ser Asn 
    1130                 1135                 1140             


Phe Leu  Phe Phe Ser Cys Trp  Glu Glu Tyr Ile Gln  Lys Tyr Phe 
    1145                 1150                 1155             


Asn Gly  Asp Trp Ser Lys Ile  Lys Asn Ile Gly Ser  Asp Thr Phe 
    1160                 1165                 1170             


Glu Phe  Leu Ile Lys Lys Cys  Gly Asn Asn Ser Ala  His Gly Glu 
    1175                 1180                 1185             


Glu Ile  Phe Asn Glu Lys Leu  Lys Asn Ala Glu Lys  Lys Cys Lys 
    1190                 1195                 1200             


Glu Asn  Glu Ser Thr Asp Thr  Asn Ile Asn Lys Ser  Glu Thr Ser 
    1205                 1210                 1215             


Cys Asp  Leu Asn Ala Thr Asn  Tyr Ile Arg Gly Cys  Gln Ser Lys 
    1220                 1225                 1230             


Thr Tyr  Asp Gly Lys Ile Phe  Pro Gly Lys Gly Gly  Glu Lys Gln 
    1235                 1240                 1245             


Trp Ile  Cys Lys Asp Thr Ile  Ile His Gly Asp Thr  Asn Gly Ala 
    1250                 1255                 1260             


Cys Ile  Pro Pro Arg Thr Gln  Asn Leu Cys Val Gly  Glu Leu Trp 
    1265                 1270                 1275             


Asp Lys  Ser Tyr Gly Gly Arg  Ser Asn Ile Lys Asn  Asp Thr Lys 
    1280                 1285                 1290             


Glu Leu  Leu Lys Glu Lys Ile  Lys Asn Ala Ile His  Lys Glu Thr 
    1295                 1300                 1305             


Glu Leu  Leu Tyr Glu Tyr His  Asp Thr Gly Thr Ala  Ile Ile Ser 
    1310                 1315                 1320             


Lys Asn  Asp Lys Lys Gly Gln  Lys Gly Lys Asn Asp  Pro Asn Gly 
    1325                 1330                 1335             


Leu Pro  Lys Gly Phe Cys His  Ala Val Gln Arg Ser  Phe Ile Asp 
    1340                 1345                 1350             


Tyr Lys  Asn Met Ile Leu Gly  Thr Ser Val Asn Ile  Tyr Glu His 
    1355                 1360                 1365             


Ile Gly  Lys Leu Gln Glu Asp  Ile Lys Lys Ile Ile  Glu Lys Gly 
    1370                 1375                 1380             


Thr Pro  Gln Gln Lys Asp Lys  Ile Gly Gly Val Gly  Ser Ser Thr 
    1385                 1390                 1395             


Glu Asn  Val Asn Ala Trp Trp  Lys Gly Ile Glu Arg  Glu Met Trp 
    1400                 1405                 1410             


Asp Ala  Val Arg Cys Ala Ile  Thr Lys Ile Asn Lys  Lys Asn Asn 
    1415                 1420                 1425             


Asn Ser  Ile Phe Asn Gly Asp  Glu Cys Gly Val Ser  Pro Pro Thr 
    1430                 1435                 1440             


Gly Asn  Asp Glu Asp Gln Ser  Val Ser Trp Phe Lys  Glu Trp Gly 
    1445                 1450                 1455             


Glu Gln  Phe Cys Ile Glu Arg  Leu Arg Tyr Glu Gln  Asn Ile Arg 
    1460                 1465                 1470             


Glu Ala  Cys Thr Ile Asn Gly  Lys Asn Glu Lys Lys  Cys Ile Asn 
    1475                 1480                 1485             


Ser Lys  Ser Gly Gln Gly Asp  Lys Ile Gln Gly Ala  Cys Lys Arg 
    1490                 1495                 1500             


Lys Cys  Glu Lys Tyr Lys Lys  Tyr Ile Ser Glu Lys  Lys Gln Glu 
    1505                 1510                 1515             


Trp Asp  Lys Gln Lys Thr Lys  Tyr Glu Asn Lys Tyr  Val Gly Lys 
    1520                 1525                 1530             


Ser Ala  Ser Asp Leu Leu Lys  Glu Asn Tyr Pro Glu  Cys Ile Ser 
    1535                 1540                 1545             


Ala Asn  Phe Asp Phe Ile Phe  Asn Asp Asn Ile Glu  Tyr Lys Thr 
    1550                 1555                 1560             


Tyr Tyr  Pro Tyr Gly Asp Tyr  Ser Ser Ile Cys Ser  Cys Glu Gln 
    1565                 1570                 1575             


Val Lys  Tyr Tyr Lys Tyr Asn  Asn Ala Glu Lys Lys  Asn Asn Lys 
    1580                 1585                 1590             


Ser Leu  Cys Tyr Glu Lys Asp  Asn Asp Met Thr Trp  Ser Lys Lys 
    1595                 1600                 1605             


Tyr Ile  Lys Lys Leu Glu Asn  Gly Arg Ser Leu Glu  Gly Val Tyr 
    1610                 1615                 1620             


Val Pro  Pro Arg Arg Gln Gln  Leu Cys Leu Tyr Glu  Leu Phe Pro 
    1625                 1630                 1635             


Ile Ile  Ile Lys Asn Glu Glu  Gly Met Glu Lys Ala  Lys Glu Glu 
    1640                 1645                 1650             


Leu Leu  Glu Thr Leu Gln Ile  Val Ala Glu Arg Glu  Ala Tyr Tyr 
    1655                 1660                 1665             


Leu Trp  Lys Gln Tyr Asn Pro  Thr Gly Lys Gly Ile  Asp Asp Ala 
    1670                 1675                 1680             


Asn Lys  Lys Ala Cys Cys Ala  Ile Arg Gly Ser Phe  Tyr Asp Leu 
    1685                 1690                 1695             


Glu Asp  Ile Ile Lys Gly Asn  Asp Leu Val His Asp  Glu Tyr Thr 
    1700                 1705                 1710             


Lys Tyr  Ile Asp Ser Lys Leu  Asn Glu Ile Phe Gly  Ser Ser Asp 
    1715                 1720                 1725             


Thr Asn  Asp Ile Asp Thr Lys  Arg Ala Arg Thr Asp  Trp Trp Glu 
    1730                 1735                 1740             


Asn Glu  Thr Ile Thr Asn Gly  Thr Asp Arg Lys Thr  Ile Arg Gln 
    1745                 1750                 1755             


Leu Val  Trp Asp Ala Met Gln  Ser Gly Val Arg Tyr  Ala Val Glu 
    1760                 1765                 1770             


Glu Lys  Asn Glu Asn Phe Pro  Leu Cys Met Gly Val  Glu His Ile 
    1775                 1780                 1785             


Gly Ile  Ala Lys Pro Gln Phe  Ile Arg Trp Leu Glu  Glu Trp Thr 
    1790                 1795                 1800             


Asn Glu  Phe Cys Glu Lys Tyr  Thr Lys Tyr Phe Glu  Asp Met Lys 
    1805                 1810                 1815             


Ser Lys  Cys Asp Pro Pro Lys  Arg Ala Asp Thr Cys  Gly Asp Asn 
    1820                 1825                 1830             


Ser Asn  Ile Glu Cys Lys Lys  Ala Cys Ala Asn Tyr  Thr Asn Trp 
    1835                 1840                 1845             


Leu Asn  Pro Lys Arg Ile Glu  Trp Asn Gly Met Ser  Asn Tyr Tyr 
    1850                 1855                 1860             


Asn Lys  Ile Tyr Arg Lys Ser  Asn Lys Glu Ser Glu  Gly Gly Lys 
    1865                 1870                 1875             


Asp Tyr  Ser Met Ile Met Ala  Pro Thr Val Ile Asp  Tyr Leu Asn 
    1880                 1885                 1890             


Lys Arg  Cys His Gly Glu Ile  Asn Gly Asn Tyr Ile  Cys Cys Ser 
    1895                 1900                 1905             


Cys Lys  Asn Ile Gly Ala Tyr  Asn Thr Thr Ser Gly  Thr Val Asn 
    1910                 1915                 1920             


Lys Lys  Leu Gln Lys Lys Glu  Thr Glu Cys Glu Glu  Glu Lys Gly 
    1925                 1930                 1935             


Pro Leu  Asp Leu Met Asn Glu  Val Leu Asn Lys Met  Asp Lys Lys 
    1940                 1945                 1950             


Tyr Ser  Ala His 
    1955         


<210>  7
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7

Lys Met Lys Cys Thr Glu Val Tyr Leu Glu His Val Glu Glu Gln Leu 
1               5                   10                  15      


Lys Glu Ile Asp Asn Ala Ile Lys Asp Tyr Lys Leu Tyr Pro Leu Asp 
            20                  25                  30          


Arg Cys Phe Asp Asp Lys Ser Lys Met Lys Val Cys Asp Leu Ile Gly 
        35                  40                  45              


Asp Ala Ile Gly Cys Lys His Lys Thr Lys Leu Asp Glu Leu Asp Glu 
    50                  55                  60                  


Trp Asn Asp Val Asp Met Arg Asp Pro Tyr Asn Lys Tyr Lys Gly Val 
65                  70                  75                  80  


Leu Ile Pro Pro Arg Arg Arg Gln Leu Cys Phe Ser Arg Ile Val Arg 
                85                  90                  95      


Gly Pro Ala Asn Leu Arg Asn Leu Lys Glu Phe Lys Glu Glu Ile Leu 
            100                 105                 110         


Lys Gly Ala Gln Ser Glu Gly Lys Phe Leu Gly Asn Tyr Tyr Asn Glu 
        115                 120                 125             


Asp Lys Asp Lys Glu Lys Ala Leu Glu Ala Met Lys Asn Ser Phe Tyr 
    130                 135                 140                 


Asp Tyr Glu Tyr Ile Ile Lys Gly Ser Asp Met Leu Thr Asn Ile Gln 
145                 150                 155                 160 


Phe Lys Asp Ile Lys Arg Lys Leu Asp Arg Leu Leu Glu Lys Glu Thr 
                165                 170                 175     


Asn Asn Thr Glu Lys Val Asp Asp Trp Trp Glu Thr Asn Lys Lys Ser 
            180                 185                 190         


Ile Trp Asn Ala Met Leu Cys Gly Tyr Lys Lys Ser Gly Asn Lys Ile 
        195                 200                 205             


Ile Asp Pro Ser Trp Cys Thr Ile Pro Thr Thr Glu Thr Pro Pro Gln 
    210                 215                 220                 


Phe Leu Arg Trp Ile Lys Glu Trp Gly Thr Asn Val Cys Ile Gln Lys 
225                 230                 235                 240 


Glu Glu His Lys Glu Tyr Val Lys Ser Lys Cys Ser Asn Val Thr Asn 
                245                 250                 255     


Leu Gly Ala Gln Glu Ser Glu Ser Lys Asn Cys Thr Ser Glu Ile Lys 
            260                 265                 270         


Lys Tyr Gln Glu Trp Ser Arg Lys Arg Ser Ile Gln Trp Glu Ala Ile 
        275                 280                 285             


Ser Glu Gly Tyr Lys Lys Tyr Lys Gly Met Asp Glu Phe Lys Asn Thr 
    290                 295                 300                 


Phe Lys Asn Ile Lys Glu Pro Asp Ala Asn Glu Pro Asn Ala Asn Glu 
305                 310                 315                 320 


Tyr Leu Lys Lys His Cys Ser Lys Cys Pro Cys Gly Phe Asn Asp Met 
                325                 330                 335     


Gln Glu Ile Thr Lys Tyr Thr Asn Ile Gly Asn Glu Ala Phe Lys Gln 
            340                 345                 350         


Ile Lys Glu Gln Val Asp Ile Pro Ala Glu Leu Glu Asp Val Ile Tyr 
        355                 360                 365             


Arg Leu Lys His His Glu Tyr Asp Lys Gly Asn Asp Tyr Ile Cys Asn 
    370                 375                 380                 


Lys Tyr Lys Asn Ile Asn Val Asn Met Lys Lys Asn Asn Asp Asp Thr 
385                 390                 395                 400 


Trp Thr Asp Leu Val Lys Asn Ser Ser Asp Ile Asn Lys Gly Val Leu 
                405                 410                 415     


Leu Pro Pro Arg Arg Lys Asn Leu Phe Leu Lys Ile Asp Glu Ser Asp 
            420                 425                 430         


Ile Cys Lys Tyr Lys Arg Asp Pro Lys Leu Phe Lys Asp Phe Ile Tyr 
        435                 440                 445             


Ser Ser Ala Ile Ser Glu Val Glu Arg Leu Lys Lys Val Tyr Gly Glu 
    450                 455                 460                 


Ala Lys Thr Lys Val Val His Ala Met Lys Tyr Ser Phe Ala Asp Ile 
465                 470                 475                 480 


Gly Ser Ile Ile Lys Gly Asp Asp Met Met Glu Asn Asn Ser Ser Asp 
                485                 490                 495     


Lys Ile Gly Lys Ile Leu Gly Asp Gly Val Gly Gln Asn Glu Lys Arg 
            500                 505                 510         


Lys Lys Trp Trp Asp Met Asn Lys Tyr His Ile Trp Glu Ser Met Leu 
        515                 520                 525             


Cys Gly Tyr Lys His Ala Tyr Gly Asn Ile Ser Glu Asn Asp Arg Lys 
    530                 535                 540                 


Met Leu Asp Ile Pro Asn Asn Asp Asp Glu His Gln Phe Leu Arg Trp 
545                 550                 555                 560 


Phe Gln Glu Trp Thr Glu Asn Phe Cys Thr Lys Arg Asn Glu Leu Tyr 
                565                 570                 575     


Glu Asn Met Val Thr Ala Cys Asn Ser Ala Lys Cys Asn Thr Ser Asn 
            580                 585                 590         


Gly Ser Val Asp Lys Lys Glu Cys Thr Glu Ala Cys Lys Asn Tyr Ser 
        595                 600                 605             


Asn Phe Ile Leu Ile Lys Lys Lys Glu Tyr Gln Ser Leu Asn Ser Gln 
    610                 615                 620                 


Tyr Asp Met Asn Tyr Lys Glu Thr Lys Ala Glu Lys Lys Glu Ser Pro 
625                 630                 635                 640 


Glu Tyr Phe Lys Asp Lys Cys Asn Gly Glu Cys Ser Cys Leu Ser Glu 
                645                 650                 655     


Tyr Phe Lys Asp Glu Thr Arg Trp Lys Asn Pro Tyr Glu Thr Leu Asp 
            660                 665                 670         


Asp Thr Glu Val Lys Asn Asn Cys Met Cys Lys Pro Pro Pro Pro Ala 
        675                 680                 685             


Ser Asn Asn Thr Ser Asp Ile Leu Gln Lys Thr Ile Pro Phe 
    690                 695                 700         


<210>  8
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8

Lys Met Lys Cys Thr Glu Val Tyr Leu Glu His Val Glu Glu Gln Leu 
1               5                   10                  15      


Asn Glu Ile Asp Asn Ala Ile Lys Asp Tyr Lys Leu Tyr Pro Leu Asp 
            20                  25                  30          


Arg Cys Phe Asp Asp Gln Thr Lys Met Lys Val Cys Asp Leu Ile Ala 
        35                  40                  45              


Asp Ala Ile Gly Cys Lys Asp Lys Thr Lys Leu Asp Glu Leu Asp Glu 
    50                  55                  60                  


Trp Asn Asp Met Asp Leu Arg Gly Thr Tyr Asn Lys His Lys Gly Val 
65                  70                  75                  80  


Leu Ile Pro Pro Arg Arg Arg Gln Leu Cys Phe Ser Arg Ile Val Arg 
                85                  90                  95      


Gly Pro Ala Asn Leu Arg Ser Leu Asn Glu Phe Lys Glu Glu Ile Leu 
            100                 105                 110         


Lys Gly Ala Gln Ser Glu Gly Lys Phe Leu Gly Asn Tyr Tyr Lys Glu 
        115                 120                 125             


His Lys Asp Lys Glu Lys Ala Leu Glu Ala Met Lys Asn Ser Phe Tyr 
    130                 135                 140                 


Asp Tyr Glu Asp Ile Ile Lys Gly Thr Asp Met Leu Thr Asn Ile Glu 
145                 150                 155                 160 


Phe Lys Asp Ile Lys Ile Lys Leu Asp Arg Leu Leu Glu Lys Glu Thr 
                165                 170                 175     


Asn Asn Thr Lys Lys Ala Glu Asp Trp Trp Lys Thr Asn Lys Lys Ser 
            180                 185                 190         


Ile Trp Asn Ala Met Leu Cys Gly Tyr Lys Lys Ser Gly Asn Lys Ile 
        195                 200                 205             


Ile Asp Pro Ser Trp Cys Thr Ile Pro Thr Thr Glu Thr Pro Pro Gln 
    210                 215                 220                 


Phe Leu Arg Trp Ile Lys Glu Trp Gly Thr Asn Val Cys Ile Gln Lys 
225                 230                 235                 240 


Gln Glu His Lys Glu Tyr Val Lys Ser Lys Cys Ser Asn Val Thr Asn 
                245                 250                 255     


Leu Gly Ala Gln Ala Ser Glu Ser Asn Asn Cys Thr Ser Glu Ile Lys 
            260                 265                 270         


Lys Tyr Gln Glu Trp Ser Arg Lys Arg Ser Ile Arg Trp Glu Thr Ile 
        275                 280                 285             


Ser Lys Arg Tyr Lys Lys Tyr Lys Arg Met Asp Ile Leu Lys Asp Val 
    290                 295                 300                 


Lys Glu Pro Asp Ala Asn Thr Tyr Leu Arg Glu His Cys Ser Lys Cys 
305                 310                 315                 320 


Pro Cys Gly Phe Asn Asp Met Glu Glu Met Asn Asn Asn Glu Asp Asn 
                325                 330                 335     


Glu Lys Glu Ala Phe Lys Gln Ile Lys Glu Gln Val Lys Ile Pro Ala 
            340                 345                 350         


Glu Leu Glu Asp Val Ile Tyr Arg Ile Lys His His Glu Tyr Asp Lys 
        355                 360                 365             


Gly Asn Asp Tyr Ile Cys Asn Lys Tyr Lys Asn Ile His Asp Arg Met 
    370                 375                 380                 


Lys Lys Asn Asn Gly Asn Phe Val Thr Asp Asn Phe Val Lys Lys Ser 
385                 390                 395                 400 


Trp Glu Ile Ser Asn Gly Val Leu Ile Pro Pro Arg Arg Lys Asn Leu 
                405                 410                 415     


Phe Leu Tyr Ile Asp Pro Ser Lys Ile Cys Glu Tyr Lys Lys Asp Pro 
            420                 425                 430         


Lys Leu Phe Lys Asp Phe Ile Tyr Trp Ser Ala Phe Thr Glu Val Glu 
        435                 440                 445             


Arg Leu Lys Lys Ala Tyr Gly Gly Ala Arg Ala Lys Val Val His Ala 
    450                 455                 460                 


Met Lys Tyr Ser Phe Thr Asp Ile Gly Ser Ile Ile Lys Gly Asp Asp 
465                 470                 475                 480 


Met Met Glu Lys Asn Ser Ser Asp Lys Ile Gly Lys Ile Leu Gly Asp 
                485                 490                 495     


Thr Asp Gly Gln Asn Glu Lys Arg Lys Lys Trp Trp Asp Met Asn Lys 
            500                 505                 510         


Tyr His Ile Trp Glu Ser Met Leu Cys Gly Tyr Arg Glu Ala Glu Gly 
        515                 520                 525             


Asp Thr Glu Thr Asn Glu Asn Cys Arg Phe Pro Asp Ile Glu Ser Val 
    530                 535                 540                 


Pro Gln Phe Leu Arg Trp Phe Gln Glu Trp Ser Glu Asn Phe Cys Asp 
545                 550                 555                 560 


Arg Arg Gln Lys Leu Tyr Asp Lys Leu Asn Ser Glu Cys Ile Ser Ala 
                565                 570                 575     


Glu Cys Thr Asn Gly Ser Val Asp Asn Ser Lys Cys Thr His Ala Cys 
            580                 585                 590         


Val Asn Tyr Lys Asn Tyr Ile Leu Thr Lys Lys Thr Glu Tyr Glu Ile 
        595                 600                 605             


Gln Thr Asn Lys Tyr Asp Asn Glu Phe Lys Asn Lys Asn Ser Asn Asp 
    610                 615                 620                 


Lys Asp Ala Pro Asp Tyr Leu Lys Glu Lys Cys Asn Asp Asn Lys Cys 
625                 630                 635                 640 


Glu Cys Leu Asn Lys His Ile Asp Asp Lys Asn Lys Thr Trp Lys Asn 
                645                 650                 655     


Pro Tyr Glu Thr Leu Glu Asp Thr Phe Lys Ser Lys Cys Asp Cys Pro 
            660                 665                 670         


Lys Pro Leu Pro Ser Pro Ile Lys Pro Asp Asp Leu Pro Pro Gln Ala 
        675                 680                 685             


Asp Glu Pro Phe 
    690         


<210>  9
<211>  1355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9

Met Asp Lys Ser Ser Ile Ala Asn Lys Ile Glu Ala Tyr Leu Gly Ala 
1               5                   10                  15      


Lys Ser Asp Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Arg Lys 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
            100                 105                 110         


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
                165                 170                 175     


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
        195                 200                 205             


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
    210                 215                 220                 


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
225                 230                 235                 240 


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
                245                 250                 255     


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
            260                 265                 270         


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
        275                 280                 285             


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
    290                 295                 300                 


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
305                 310                 315                 320 


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
                325                 330                 335     


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
            340                 345                 350         


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
        355                 360                 365             


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
    370                 375                 380                 


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
385                 390                 395                 400 


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
                405                 410                 415     


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
            420                 425                 430         


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
        435                 440                 445             


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
    450                 455                 460                 


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
465                 470                 475                 480 


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
                485                 490                 495     


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
            500                 505                 510         


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
        515                 520                 525             


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
    530                 535                 540                 


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
545                 550                 555                 560 


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
                565                 570                 575     


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
            580                 585                 590         


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
        595                 600                 605             


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
    610                 615                 620                 


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
625                 630                 635                 640 


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
                645                 650                 655     


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
            660                 665                 670         


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
        675                 680                 685             


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
    690                 695                 700                 


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
705                 710                 715                 720 


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly 
                725                 730                 735     


Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp 
            740                 745                 750         


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
        755                 760                 765             


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys Lys 
    770                 775                 780                 


Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Glu 
785                 790                 795                 800 


Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Asp Cys Lys 
                805                 810                 815     


Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln 
            820                 825                 830         


Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg 
        835                 840                 845             


Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala 
    850                 855                 860                 


Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu 
865                 870                 875                 880 


Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu 
                885                 890                 895     


Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr 
            900                 905                 910         


Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser Lys 
        915                 920                 925             


Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu 
    930                 935                 940                 


Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro 
945                 950                 955                 960 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Lys Lys Asn Asn 
                965                 970                 975     


Lys Ser Leu Cys His Glu Lys Gly Asn Asp Arg Thr Trp Ser Lys Lys 
            980                 985                 990         


Tyr Ile Lys Lys Leu Glu Asn Gly  Arg Thr Leu Glu Gly  Val Tyr Val 
        995                 1000                 1005             


Pro Pro  Arg Arg Gln Gln Leu  Cys Leu Tyr Glu Leu  Phe Pro Ile 
    1010                 1015                 1020             


Ile Ile  Lys Asn Lys Asn Asp  Ile Thr Asn Ala Lys  Lys Glu Leu 
    1025                 1030                 1035             


Leu Glu  Thr Leu Gln Ile Val  Ala Glu Arg Glu Ala  Tyr Tyr Leu 
    1040                 1045                 1050             


Trp Lys  Gln Tyr His Ala His  Asn Asp Thr Thr Tyr  Leu Ala His 
    1055                 1060                 1065             


Lys Lys  Ala Cys Cys Ala Ile  Arg Gly Ser Phe Tyr  Asp Leu Glu 
    1070                 1075                 1080             


Asp Ile  Ile Lys Gly Asn Asp  Leu Val His Asp Glu  Tyr Thr Lys 
    1085                 1090                 1095             


Tyr Ile  Asp Ser Lys Leu Asn  Glu Ile Phe Asp Ser  Ser Asn Lys 
    1100                 1105                 1110             


Asn Asp  Ile Glu Thr Lys Arg  Ala Arg Thr Asp Trp  Trp Glu Asn 
    1115                 1120                 1125             


Glu Ala  Ile Ala Val Pro Asn  Ile Thr Gly Ala Asn  Lys Ser Asp 
    1130                 1135                 1140             


Pro Lys  Thr Ile Arg Gln Leu  Val Trp Asp Ala Met  Gln Ser Gly 
    1145                 1150                 1155             


Val Arg  Lys Ala Ile Asp Glu  Glu Lys Glu Lys Lys  Lys Pro Asn 
    1160                 1165                 1170             


Glu Asn  Phe Pro Pro Cys Met  Gly Val Gln His Ile  Gly Ile Ala 
    1175                 1180                 1185             


Lys Pro  Gln Phe Ile Arg Trp  Leu Glu Glu Trp Thr  Asn Glu Phe 
    1190                 1195                 1200             


Cys Glu  Lys Tyr Thr Lys Tyr  Phe Glu Asp Met Lys  Ser Asn Cys 
    1205                 1210                 1215             


Asn Leu  Arg Lys Gly Ala Asp  Asp Cys Asp Asp Asn  Ser Asn Ile 
    1220                 1225                 1230             


Glu Cys  Lys Lys Ala Cys Ala  Asn Tyr Thr Asn Trp  Leu Asn Pro 
    1235                 1240                 1245             


Lys Arg  Ile Glu Trp Asn Gly  Met Ser Asn Tyr Tyr  Asn Lys Ile 
    1250                 1255                 1260             


Tyr Arg  Lys Ser Asn Lys Glu  Ser Glu Asp Gly Lys  Asp Tyr Ser 
    1265                 1270                 1275             


Met Ile  Met Glu Pro Thr Val  Ile Asp Tyr Leu Asn  Lys Arg Cys 
    1280                 1285                 1290             


Asn Gly  Glu Ile Asn Gly Asn  Tyr Ile Cys Cys Ser  Cys Lys Asn 
    1295                 1300                 1305             


Ile Gly  Glu Asn Ser Thr Ser  Gly Thr Val Asn Lys  Lys Leu Gln 
    1310                 1315                 1320             


Lys Lys  Glu Thr Gln Cys Glu  Asp Asn Lys Gly Pro  Leu Asp Leu 
    1325                 1330                 1335             


Met Asn  Lys Val Leu Asn Lys  Met Asp Pro Lys Tyr  Ser Glu His 
    1340                 1345                 1350             


Lys Met  
    1355 


<210>  10
<211>  1352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10

Met Asp Ser Thr Ser Thr Ile Ala Asn Lys Ile Glu Glu Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asp Asp Ser Lys Ile Asp Glu Leu Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Asp Pro Cys Glu Lys Lys Leu Pro Pro Tyr Asp Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Gly Lys Pro Glu Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Glu Arg Leu Cys Thr Tyr Asn Leu Glu Asn 
            100                 105                 110         


Leu Lys Phe Asp Lys Ile Arg Asp Asn Asn Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Lys Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Lys Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu 
            180                 185                 190         


Asn Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Lys Tyr Thr 
        195                 200                 205             


Lys Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly 
225                 230                 235                 240 


Trp Arg Thr Ser Gly Lys Ser Asp Arg Lys Lys Asn Phe Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Lys Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr 
        275                 280                 285             


Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser 
305                 310                 315                 320 


Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp 
                325                 330                 335     


Lys Thr Glu Trp Glu Asn Gln Glu Asn Lys Tyr Lys Asp Leu Tyr Glu 
            340                 345                 350         


Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp 
        355                 360                 365             


Tyr Val Lys Asp Phe Phe Glu Lys Leu Glu Ala Asn Tyr Ser Ser Leu 
    370                 375                 380                 


Glu Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys 
385                 390                 395                 400 


Leu Ser Phe Ile Leu Asn Pro Ser Asp Ala Asn Asn Pro Ser Gly Glu 
                405                 410                 415     


Thr Ala Asn His Asn Asp Glu Ala Cys Asn Cys Asn Glu Ser Gly Ile 
            420                 425                 430         


Ser Ser Val Gly Gln Ala Gln Thr Ser Gly Pro Ser Ser Asn Lys Thr 
        435                 440                 445             


Cys Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Glu Cys Lys 
    450                 455                 460                 


Asp Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Lys Ile Cys 
465                 470                 475                 480 


Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys Gln 
                485                 490                 495     


Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg Gly 
            500                 505                 510         


Ser Ser Ser Asn Asp Ser Cys Asp Asn Lys Asn Gln Asp Glu Cys Gln 
        515                 520                 525             


Lys Lys Leu Glu Lys Val Phe Ala Ser Leu Thr Asn Gly Tyr Lys Cys 
    530                 535                 540                 


Asp Lys Cys Lys Ser Gly Thr Ser Arg Ser Lys Lys Lys Trp Ile Trp 
545                 550                 555                 560 


Lys Lys Ser Ser Gly Asn Glu Glu Gly Leu Gln Glu Glu Tyr Ala Asn 
                565                 570                 575     


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Tyr Leu Gly Asn Leu 
            580                 585                 590         


Pro Lys Leu Glu Asn Val Cys Glu Asp Val Lys Asp Ile Asn Phe Asp 
        595                 600                 605             


Thr Lys Glu Lys Phe Leu Ala Gly Cys Leu Ile Val Ser Phe His Glu 
    610                 615                 620                 


Gly Lys Asn Leu Lys Lys Arg Tyr Pro Gln Asn Lys Asn Ser Gly Asn 
625                 630                 635                 640 


Lys Glu Asn Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly 
                645                 650                 655     


Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp 
            660                 665                 670         


Leu Glu Leu Asn Leu Gln Asn Asn Phe Gly Lys Leu Phe Gly Lys Tyr 
        675                 680                 685             


Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp 
705                 710                 715                 720 


Thr Ala Met Lys His Gly Ala Glu Met Asn Ile Thr Thr Cys Asn Ala 
                725                 730                 735     


Asp Gly Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr 
            740                 745                 750         


Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu 
        755                 760                 765             


Asn Phe Cys Glu Gln Arg Gln Ala Lys Val Lys Asp Val Ile Thr Asn 
    770                 775                 780                 


Cys Lys Ser Cys Lys Glu Ser Gly Asn Lys Cys Lys Thr Glu Cys Lys 
785                 790                 795                 800 


Thr Lys Cys Lys Asp Glu Cys Glu Lys Tyr Lys Lys Phe Ile Glu Ala 
                805                 810                 815     


Cys Gly Thr Ala Gly Gly Gly Ile Gly Thr Ala Gly Ser Pro Trp Ser 
            820                 825                 830         


Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys His Ile Glu Asp 
        835                 840                 845             


Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly Thr Ser Ser 
    850                 855                 860                 


Thr Thr Asn Ala Ala Ala Ser Thr Asp Glu Asn Lys Cys Val Gln Ser 
865                 870                 875                 880 


Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr 
                885                 890                 895     


Pro Ser Ser Tyr Leu Ser Asn Val Leu Asp Asp Asn Ile Cys Gly Ala 
            900                 905                 910         


Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Glu Lys 
        915                 920                 925             


Cys Asn Lys Glu Arg Asp Lys Ser Lys Ser Gln Ser Ser Asp Thr Leu 
    930                 935                 940                 


Val Val Val Asn Val Pro Ser Pro Leu Gly Asn Thr Pro Tyr Arg Tyr 
945                 950                 955                 960 


Lys Tyr Ala Cys Gln Cys Lys Ile Pro Gly Gly Gly Gly Ser Gly Gly 
                965                 970                 975     


Gly Gly Ser Ala Glu Lys Lys Asn Asn Lys Ser Leu Cys Tyr Glu Lys 
            980                 985                 990         


Asp Asn Asp Met Thr Trp Ser Lys  Lys Tyr Ile Lys Lys  Leu Glu Asn 
        995                 1000                 1005             


Gly Arg  Ser Leu Glu Gly Val  Tyr Val Pro Pro Arg  Arg Gln Gln 
    1010                 1015                 1020             


Leu Cys  Leu Tyr Glu Leu Phe  Pro Ile Ile Ile Lys  Asn Glu Glu 
    1025                 1030                 1035             


Gly Met  Glu Lys Ala Lys Glu  Glu Leu Leu Glu Thr  Leu Gln Ile 
    1040                 1045                 1050             


Val Ala  Glu Arg Glu Ala Tyr  Tyr Leu Trp Lys Gln  Tyr Asn Pro 
    1055                 1060                 1065             


Thr Gly  Lys Gly Ile Asp Asp  Ala Asn Lys Lys Ala  Cys Cys Ala 
    1070                 1075                 1080             


Ile Arg  Gly Ser Phe Tyr Asp  Leu Glu Asp Ile Ile  Lys Gly Asn 
    1085                 1090                 1095             


Asp Leu  Val His Asp Glu Tyr  Thr Lys Tyr Ile Asp  Ser Lys Leu 
    1100                 1105                 1110             


Asn Glu  Ile Phe Gly Ser Ser  Asp Thr Asn Asp Ile  Asp Thr Lys 
    1115                 1120                 1125             


Arg Ala  Arg Thr Asp Trp Trp  Glu Asn Glu Thr Ile  Thr Asn Gly 
    1130                 1135                 1140             


Thr Asp  Arg Lys Thr Ile Arg  Gln Leu Val Trp Asp  Ala Met Gln 
    1145                 1150                 1155             


Ser Gly  Val Arg Tyr Ala Val  Glu Glu Lys Asn Glu  Asn Phe Pro 
    1160                 1165                 1170             


Leu Cys  Met Gly Val Glu His  Ile Gly Ile Ala Lys  Pro Gln Phe 
    1175                 1180                 1185             


Ile Arg  Trp Leu Glu Glu Trp  Thr Asn Glu Phe Cys  Glu Lys Tyr 
    1190                 1195                 1200             


Thr Lys  Tyr Phe Glu Asp Met  Lys Ser Lys Cys Asp  Pro Pro Lys 
    1205                 1210                 1215             


Arg Ala  Asp Thr Cys Gly Asp  Asn Ser Asn Ile Glu  Cys Lys Lys 
    1220                 1225                 1230             


Ala Cys  Ala Asn Tyr Thr Asn  Trp Leu Asn Pro Lys  Arg Ile Glu 
    1235                 1240                 1245             


Trp Asn  Gly Met Ser Asn Tyr  Tyr Asn Lys Ile Tyr  Arg Lys Ser 
    1250                 1255                 1260             


Asn Lys  Glu Ser Glu Gly Gly  Lys Asp Tyr Ser Met  Ile Met Ala 
    1265                 1270                 1275             


Pro Thr  Val Ile Asp Tyr Leu  Asn Lys Arg Cys His  Gly Glu Ile 
    1280                 1285                 1290             


Asn Gly  Asn Tyr Ile Cys Cys  Ser Cys Lys Asn Ile  Gly Ala Tyr 
    1295                 1300                 1305             


Asn Thr  Thr Ser Gly Thr Val  Asn Lys Lys Leu Gln  Lys Lys Glu 
    1310                 1315                 1320             


Thr Glu  Cys Glu Glu Glu Lys  Gly Pro Leu Asp Leu  Met Asn Glu 
    1325                 1330                 1335             


Val Leu  Asn Lys Met Asp Lys  Lys Tyr Ser Ala His  Lys Met 
    1340                 1345                 1350         


<210>  11
<211>  1186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11

Met Asp Lys Ser Ser Ile Ala Asn Lys Ile Glu Ala Tyr Leu Gly Ala 
1               5                   10                  15      


Lys Ser Asp Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Arg Lys 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
            100                 105                 110         


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
                165                 170                 175     


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
        195                 200                 205             


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
    210                 215                 220                 


Ile Thr Cys Gly Ala Arg Ser Asn Asp Gly Ser Gly Ser Gly Leu Glu 
225                 230                 235                 240 


Leu Cys Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu 
                245                 250                 255     


Asp Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp 
            260                 265                 270         


Phe Tyr Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg 
        275                 280                 285             


Glu Glu Cys Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr 
    290                 295                 300                 


Cys Ser Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys 
305                 310                 315                 320 


Lys Trp Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu 
                325                 330                 335     


Tyr Gln Gln Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr 
            340                 345                 350         


Asp Asp Tyr Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser 
        355                 360                 365             


Ser Leu Glu Asn Tyr Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Ser Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn 
385                 390                 395                 400 


Trp Ile Trp Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu 
                405                 410                 415     


Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu 
            420                 425                 430         


Val Val Cys Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn 
        435                 440                 445             


Ile Arg Thr Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe 
    450                 455                 460                 


His Glu Gly Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp 
465                 470                 475                 480 


Asn Gly Lys Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr 
                485                 490                 495     


Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys 
            500                 505                 510         


Asp Leu Glu Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Gly Gly 
        515                 520                 525             


Gly Gly Ser Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr 
    530                 535                 540                 


Asn Lys Lys Tyr Ile Trp Leu Ala Met Lys His Gly Ala Gly Met Asn 
545                 550                 555                 560 


Ser Thr Thr Cys Cys Gly Asp Gly Ser Val Thr Gly Ser Gly Ser Ser 
                565                 570                 575     


Cys Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe 
            580                 585                 590         


Leu Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg Gln Glu Lys Val 
        595                 600                 605             


Lys Pro Val Ile Glu Asn Cys Lys Ser Cys Lys Glu Ser Gly Gly Thr 
    610                 615                 620                 


Cys Asn Gly Glu Cys Lys Thr Glu Cys Lys Asn Lys Cys Glu Val Tyr 
625                 630                 635                 640 


Lys Lys Phe Ile Glu Asp Cys Lys Gly Gly Asp Gly Thr Ala Gly Ser 
                645                 650                 655     


Ser Trp Val Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys Tyr 
            660                 665                 670         


Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly 
        675                 680                 685             


Ser Gly Ser Gly Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His 
    690                 695                 700                 


Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val 
705                 710                 715                 720 


Leu Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr 
                725                 730                 735     


Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser 
            740                 745                 750         


Lys Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro 
        755                 760                 765             


Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile 
    770                 775                 780                 


Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Gly Ser 
785                 790                 795                 800 


Gly Ala Glu Lys Lys Asn Asn Lys Ser Leu Cys His Glu Lys Gly Asn 
                805                 810                 815     


Asp Arg Thr Trp Ser Lys Lys Tyr Ile Lys Lys Leu Glu Asn Gly Arg 
            820                 825                 830         


Thr Leu Glu Gly Val Tyr Val Pro Pro Arg Arg Gln Gln Leu Cys Leu 
        835                 840                 845             


Tyr Glu Leu Phe Pro Ile Ile Ile Lys Asn Lys Asn Asp Ile Thr Asn 
    850                 855                 860                 


Ala Lys Lys Glu Leu Leu Glu Thr Leu Gln Ile Val Ala Glu Arg Glu 
865                 870                 875                 880 


Ala Tyr Tyr Leu Trp Lys Gln Tyr His Ala His Asn Asp Thr Thr Tyr 
                885                 890                 895     


Leu Ala His Lys Lys Ala Cys Cys Ala Ile Arg Gly Ser Phe Tyr Asp 
            900                 905                 910         


Leu Glu Asp Ile Ile Lys Gly Asn Asp Leu Val His Asp Glu Tyr Thr 
        915                 920                 925             


Lys Tyr Ile Asp Ser Lys Leu Asn Glu Ile Phe Asp Ser Ser Asn Lys 
    930                 935                 940                 


Asn Asp Ile Glu Thr Lys Arg Ala Arg Thr Asp Trp Trp Glu Asn Glu 
945                 950                 955                 960 


Ala Ile Ala Val Pro Asn Ile Thr Gly Ala Asn Lys Ser Asp Pro Lys 
                965                 970                 975     


Thr Ile Arg Gln Leu Val Trp Asp Ala Met Gln Ser Gly Val Arg Lys 
            980                 985                 990         


Ala Ile Asp Glu Glu Lys Glu Lys  Lys Lys Pro Asn Glu  Asn Phe Pro 
        995                 1000                 1005             


Pro Cys  Met Gly Val Gln His  Ile Gly Ile Ala Lys  Pro Gln Phe 
    1010                 1015                 1020             


Ile Arg  Trp Leu Glu Glu Trp  Thr Asn Glu Phe Cys  Glu Lys Tyr 
    1025                 1030                 1035             


Thr Lys  Tyr Phe Glu Asp Met  Lys Ser Asn Cys Asn  Leu Arg Lys 
    1040                 1045                 1050             


Gly Ala  Asp Asp Cys Asp Asp  Asn Ser Asn Ile Glu  Cys Lys Lys 
    1055                 1060                 1065             


Ala Cys  Ala Asn Tyr Thr Asn  Trp Leu Asn Pro Lys  Arg Ile Glu 
    1070                 1075                 1080             


Trp Asn  Gly Met Ser Asn Tyr  Tyr Asn Lys Ile Tyr  Arg Lys Ser 
    1085                 1090                 1095             


Asn Lys  Glu Ser Glu Asp Gly  Lys Asp Tyr Ser Met  Ile Met Glu 
    1100                 1105                 1110             


Pro Thr  Val Ile Asp Tyr Leu  Asn Lys Arg Cys Asn  Gly Glu Ile 
    1115                 1120                 1125             


Asn Gly  Asn Tyr Ile Cys Cys  Ser Cys Lys Asn Ile  Gly Glu Asn 
    1130                 1135                 1140             


Ser Thr  Ser Gly Thr Val Asn  Lys Lys Leu Gln Lys  Lys Glu Thr 
    1145                 1150                 1155             


Gln Cys  Glu Asp Asn Lys Gly  Pro Leu Asp Leu Met  Asn Lys Val 
    1160                 1165                 1170             


Leu Asn  Lys Met Asp Pro Lys  Tyr Ser Glu His Lys  Met 
    1175                 1180                 1185     


<210>  12
<211>  1186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12

Met Asp Ser Thr Ser Thr Ile Ala Asn Lys Ile Glu Glu Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asp Asp Ser Lys Ile Asp Glu Leu Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Asp Pro Cys Glu Lys Lys Leu Pro Pro Tyr Asp Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Gly Lys Pro Glu Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Glu Arg Leu Cys Thr Tyr Asn Leu Glu Asn 
            100                 105                 110         


Leu Lys Phe Asp Lys Ile Arg Asp Asn Asn Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Lys Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Lys Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu 
            180                 185                 190         


Asn Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Lys Tyr Thr 
        195                 200                 205             


Lys Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly 
225                 230                 235                 240 


Trp Arg Thr Ser Gly Lys Ser Asp Arg Lys Lys Asn Phe Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Lys Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr 
        275                 280                 285             


Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser 
305                 310                 315                 320 


Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp 
                325                 330                 335     


Lys Thr Glu Trp Glu Asn Gln Glu Asn Lys Tyr Lys Asp Leu Tyr Glu 
            340                 345                 350         


Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp 
        355                 360                 365             


Tyr Val Lys Asp Phe Phe Glu Lys Leu Glu Ala Asn Tyr Ser Ser Leu 
    370                 375                 380                 


Glu Asn Tyr Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Ser Lys Ser Gly Thr Ser Arg Ser Lys Lys Lys Trp Ile Trp 
                405                 410                 415     


Lys Lys Ser Ser Gly Asn Glu Glu Gly Leu Gln Glu Glu Tyr Ala Asn 
            420                 425                 430         


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Tyr Leu Gly Asn Leu 
        435                 440                 445             


Pro Lys Leu Glu Asn Val Cys Glu Asp Val Lys Asp Ile Asn Phe Asp 
    450                 455                 460                 


Thr Lys Glu Lys Phe Leu Ala Gly Cys Leu Ile Val Ser Phe His Glu 
465                 470                 475                 480 


Gly Lys Asn Leu Lys Lys Arg Tyr Pro Gln Asn Lys Asn Ser Gly Asn 
                485                 490                 495     


Lys Glu Asn Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly 
            500                 505                 510         


Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp 
        515                 520                 525             


Leu Glu Leu Asn Leu Gln Asn Asn Phe Gly Lys Leu Phe Gly Gly Gly 
    530                 535                 540                 


Gly Ser Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn 
545                 550                 555                 560 


Lys Lys Tyr Ile Trp Thr Ala Met Lys His Gly Ala Glu Met Asn Ile 
                565                 570                 575     


Thr Thr Cys Asn Ala Asp Gly Ser Val Thr Gly Ser Gly Ser Ser Cys 
            580                 585                 590         


Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu 
        595                 600                 605             


Gln Glu Trp Val Glu Asn Phe Cys Glu Gln Arg Gln Ala Lys Val Lys 
    610                 615                 620                 


Asp Val Ile Thr Asn Cys Lys Ser Cys Lys Glu Ser Gly Asn Lys Cys 
625                 630                 635                 640 


Lys Thr Glu Cys Lys Thr Lys Cys Lys Asp Glu Cys Glu Lys Tyr Lys 
                645                 650                 655     


Lys Phe Ile Glu Ala Cys Gly Thr Ala Gly Gly Gly Ile Gly Thr Ala 
            660                 665                 670         


Gly Ser Pro Trp Ser Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser 
        675                 680                 685             


Lys His Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn 
    690                 695                 700                 


Cys Gly Gly Gly Gly Ser Cys Val Gln Ser Asp Ile Asp Ser Phe Phe 
705                 710                 715                 720 


Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser 
                725                 730                 735     


Asn Val Leu Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr 
            740                 745                 750         


Thr Tyr Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Arg Asp 
        755                 760                 765             


Lys Ser Lys Ser Gln Ser Ser Asp Thr Leu Val Val Val Asn Val Pro 
    770                 775                 780                 


Ser Pro Leu Gly Asn Thr Pro Tyr Arg Tyr Lys Tyr Ala Cys Gln Cys 
785                 790                 795                 800 


Lys Ile Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Lys 
                805                 810                 815     


Lys Asn Asn Lys Ser Leu Cys Tyr Glu Lys Asp Asn Asp Met Thr Trp 
            820                 825                 830         


Ser Lys Lys Tyr Ile Lys Lys Leu Glu Asn Gly Arg Ser Leu Glu Gly 
        835                 840                 845             


Val Tyr Val Pro Pro Arg Arg Gln Gln Leu Cys Leu Tyr Glu Leu Phe 
    850                 855                 860                 


Pro Ile Ile Ile Lys Asn Glu Glu Gly Met Glu Lys Ala Lys Glu Glu 
865                 870                 875                 880 


Leu Leu Glu Thr Leu Gln Ile Val Ala Glu Arg Glu Ala Tyr Tyr Leu 
                885                 890                 895     


Trp Lys Gln Tyr Asn Pro Thr Gly Lys Gly Ile Asp Asp Ala Asn Lys 
            900                 905                 910         


Lys Ala Cys Cys Ala Ile Arg Gly Ser Phe Tyr Asp Leu Glu Asp Ile 
        915                 920                 925             


Ile Lys Gly Asn Asp Leu Val His Asp Glu Tyr Thr Lys Tyr Ile Asp 
    930                 935                 940                 


Ser Lys Leu Asn Glu Ile Phe Gly Ser Ser Asp Thr Asn Asp Ile Asp 
945                 950                 955                 960 


Thr Lys Arg Ala Arg Thr Asp Trp Trp Glu Asn Glu Thr Ile Thr Asn 
                965                 970                 975     


Gly Thr Asp Arg Lys Thr Ile Arg Gln Leu Val Trp Asp Ala Met Gln 
            980                 985                 990         


Ser Gly Val Arg Tyr Ala Val Glu  Glu Lys Asn Glu Asn  Phe Pro Leu 
        995                 1000                 1005             


Cys Met  Gly Val Glu His Ile  Gly Ile Ala Lys Pro  Gln Phe Ile 
    1010                 1015                 1020             


Arg Trp  Leu Glu Glu Trp Thr  Asn Glu Phe Cys Glu  Lys Tyr Thr 
    1025                 1030                 1035             


Lys Tyr  Phe Glu Asp Met Lys  Ser Lys Cys Asp Pro  Pro Lys Arg 
    1040                 1045                 1050             


Ala Asp  Thr Cys Gly Asp Asn  Ser Asn Ile Glu Cys  Lys Lys Ala 
    1055                 1060                 1065             


Cys Ala  Asn Tyr Thr Asn Trp  Leu Asn Pro Lys Arg  Ile Glu Trp 
    1070                 1075                 1080             


Asn Gly  Met Ser Asn Tyr Tyr  Asn Lys Ile Tyr Arg  Lys Ser Asn 
    1085                 1090                 1095             


Lys Glu  Ser Glu Gly Gly Lys  Asp Tyr Ser Met Ile  Met Ala Pro 
    1100                 1105                 1110             


Thr Val  Ile Asp Tyr Leu Asn  Lys Arg Cys His Gly  Glu Ile Asn 
    1115                 1120                 1125             


Gly Asn  Tyr Ile Cys Cys Ser  Cys Lys Asn Ile Gly  Ala Tyr Asn 
    1130                 1135                 1140             


Thr Thr  Ser Gly Thr Val Asn  Lys Lys Leu Gln Lys  Lys Glu Thr 
    1145                 1150                 1155             


Glu Cys  Glu Glu Glu Lys Gly  Pro Leu Asp Leu Met  Asn Glu Val 
    1160                 1165                 1170             


Leu Asn  Lys Met Asp Lys Lys  Tyr Ser Ala His Lys  Met 
    1175                 1180                 1185     


<210>  13
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13

Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp Lys Lys 
1               5                   10                  15      


Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn Thr Ile 
            20                  25                  30          


Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys Leu Asp 
        35                  40                  45              


Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr Asn Ser 
    50                  55                  60                  


Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly Lys Asn 
65                  70                  75                  80  


Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys Lys Leu 
                85                  90                  95      


Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile Lys 
            100                 105                 110         


Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu Leu Asn 
        115                 120                 125             


Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys Lys Asn 
    130                 135                 140                 


Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu Leu Arg 
145                 150                 155                 160 


Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala Met Lys 
                165                 170                 175     


His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly Ser Val 
            180                 185                 190         


Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu Ile 
        195                 200                 205             


Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe Cys Lys 
    210                 215                 220                 


Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys Lys Ser Cys 
225                 230                 235                 240 


Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Glu Cys Lys 
                245                 250                 255     


Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Asp Cys Lys Gly Gly 
            260                 265                 270         


Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln Ile Tyr 
        275                 280                 285             


Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala 
    290                 295                 300                 


Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala Glu Asn 
305                 310                 315                 320 


Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp 
                325                 330                 335     


Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp Asp 
            340                 345                 350         


Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr 
        355                 360                 365             


Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser Lys Leu Gln 
    370                 375                 380                 


Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
385                 390                 395                 400 


Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro 
                405                 410                 


<210>  14
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14

Lys Ser Gly Thr Ser Arg Ser Lys Lys Lys Trp Ile Trp Lys Lys Ser 
1               5                   10                  15      


Ser Gly Asn Glu Glu Gly Leu Gln Glu Glu Tyr Ala Asn Thr Ile Gly 
            20                  25                  30          


Leu Pro Pro Arg Thr Gln Ser Leu Tyr Leu Gly Asn Leu Pro Lys Leu 
        35                  40                  45              


Glu Asn Val Cys Glu Asp Val Lys Asp Ile Asn Phe Asp Thr Lys Glu 
    50                  55                  60                  


Lys Phe Leu Ala Gly Cys Leu Ile Val Ser Phe His Glu Gly Lys Asn 
65                  70                  75                  80  


Leu Lys Lys Arg Tyr Pro Gln Asn Lys Asn Ser Gly Asn Lys Glu Asn 
                85                  90                  95      


Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile 
            100                 105                 110         


Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu Leu 
        115                 120                 125             


Asn Leu Gln Asn Asn Phe Gly Lys Leu Phe Gly Lys Tyr Ile Lys Lys 
    130                 135                 140                 


Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu Leu 
145                 150                 155                 160 


Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Thr Ala Met 
                165                 170                 175     


Lys His Gly Ala Glu Met Asn Ile Thr Thr Cys Asn Ala Asp Gly Ser 
            180                 185                 190         


Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu 
        195                 200                 205             


Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu Asn Phe Cys 
    210                 215                 220                 


Glu Gln Arg Gln Ala Lys Val Lys Asp Val Ile Thr Asn Cys Lys Ser 
225                 230                 235                 240 


Cys Lys Glu Ser Gly Asn Lys Cys Lys Thr Glu Cys Lys Thr Lys Cys 
                245                 250                 255     


Lys Asp Glu Cys Glu Lys Tyr Lys Lys Phe Ile Glu Ala Cys Gly Thr 
            260                 265                 270         


Ala Gly Gly Gly Ile Gly Thr Ala Gly Ser Pro Trp Ser Lys Arg Trp 
        275                 280                 285             


Asp Gln Ile Tyr Lys Arg Tyr Ser Lys His Ile Glu Asp Ala Lys Arg 
    290                 295                 300                 


Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly Thr Ser Ser Thr Thr Asn 
305                 310                 315                 320 


Ala Ala Ala Ser Thr Asp Glu Asn Lys Cys Val Gln Ser Asp Ile Asp 
                325                 330                 335     


Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser 
            340                 345                 350         


Tyr Leu Ser Asn Val Leu Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala 
        355                 360                 365             


Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys 
    370                 375                 380                 


Glu Arg Asp Lys Ser Lys Ser Gln Ser Ser Asp Thr Leu Val Val Val 
385                 390                 395                 400 


Asn Val Pro Ser Pro Leu Gly Asn Thr Pro Tyr Arg Tyr Lys Tyr Ala 
                405                 410                 415     


Cys Gln Cys Lys Ile Pro 
            420         


<210>  15
<211>  1807
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15

Met Asp Lys Ser Ser Ile Ala Asn Lys Ile Glu Ala Tyr Leu Gly Ala 
1               5                   10                  15      


Lys Ser Asp Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Arg Lys 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
            100                 105                 110         


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
                165                 170                 175     


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
        195                 200                 205             


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
    210                 215                 220                 


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
225                 230                 235                 240 


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
                245                 250                 255     


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
            260                 265                 270         


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
        275                 280                 285             


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
    290                 295                 300                 


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
305                 310                 315                 320 


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
                325                 330                 335     


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
            340                 345                 350         


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
        355                 360                 365             


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
    370                 375                 380                 


Asn Tyr Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Ser Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
                405                 410                 415     


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
            420                 425                 430         


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
        435                 440                 445             


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
    450                 455                 460                 


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
465                 470                 475                 480 


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
                485                 490                 495     


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
            500                 505                 510         


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
        515                 520                 525             


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
    530                 535                 540                 


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
545                 550                 555                 560 


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
                565                 570                 575     


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly 
            580                 585                 590         


Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp 
        595                 600                 605             


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
    610                 615                 620                 


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys Lys 
625                 630                 635                 640 


Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Glu 
                645                 650                 655     


Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Asp Cys Lys 
            660                 665                 670         


Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln 
        675                 680                 685             


Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg 
    690                 695                 700                 


Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala 
705                 710                 715                 720 


Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu 
                725                 730                 735     


Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu 
            740                 745                 750         


Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr 
        755                 760                 765             


Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser Lys 
    770                 775                 780                 


Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu 
785                 790                 795                 800 


Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro 
                805                 810                 815     


Thr Asn Glu Glu Thr Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp 
            820                 825                 830         


Ser Cys Gly Ser Ala Arg Thr Met Lys Arg Gly Tyr Lys Asn Asp Asn 
        835                 840                 845             


Tyr Glu Leu Cys Lys Tyr Asn Gly Val Asp Val Lys Pro Thr Thr Val 
    850                 855                 860                 


Arg Ser Asn Ser Ser Lys Leu Asp Asp Lys Asp Val Thr Phe Phe Asn 
865                 870                 875                 880 


Leu Phe Glu Gln Trp Asn Lys Glu Ile Gln Tyr Gln Ile Glu Gln Tyr 
                885                 890                 895     


Met Thr Asn Thr Lys Ile Ser Cys Asn Asn Glu Lys Asn Val Leu Ser 
            900                 905                 910         


Arg Val Ser Asp Glu Ala Ala Gln Pro Lys Phe Ser Asp Asn Glu Arg 
        915                 920                 925             


Asp Arg Asn Ser Ile Thr His Glu Asp Lys Asn Cys Lys Glu Lys Cys 
    930                 935                 940                 


Lys Cys Tyr Ser Leu Trp Ile Glu Lys Ile Asn Asp Gln Trp Asp Lys 
945                 950                 955                 960 


Gln Lys Asp Asn Tyr Asn Lys Phe Gln Arg Lys Gln Ile Tyr Asp Ala 
                965                 970                 975     


Asn Lys Gly Ser Gln Asn Lys Lys Val Val Ser Leu Ser Asn Phe Leu 
            980                 985                 990         


Phe Phe Ser Cys Trp Glu Glu Tyr  Ile Gln Lys Tyr Phe  Asn Gly Asp 
        995                 1000                 1005             


Trp Ser  Lys Ile Lys Asn Ile  Gly Ser Asp Thr Phe  Glu Phe Leu 
    1010                 1015                 1020             


Ile Lys  Lys Cys Gly Asn Asp  Ser Gly Asp Gly Glu  Thr Ile Phe 
    1025                 1030                 1035             


Ser Glu  Lys Leu Asn Asn Ala  Glu Lys Lys Cys Lys  Glu Asn Glu 
    1040                 1045                 1050             


Ser Thr  Asn Asn Lys Met Lys  Ser Ser Glu Thr Ser  Cys Asp Cys 
    1055                 1060                 1065             


Ser Glu  Pro Ile Tyr Ile Arg  Gly Cys Gln Pro Lys  Ile Tyr Asp 
    1070                 1075                 1080             


Gly Lys  Ile Phe Pro Gly Lys  Gly Gly Glu Lys Gln  Trp Ile Cys 
    1085                 1090                 1095             


Lys Asp  Thr Ile Ile His Gly  Asp Thr Asn Gly Ala  Cys Ile Pro 
    1100                 1105                 1110             


Pro Arg  Thr Gln Asn Leu Cys  Val Gly Glu Leu Trp  Asp Lys Arg 
    1115                 1120                 1125             


Tyr Gly  Gly Arg Ser Asn Ile  Lys Asn Asp Thr Lys  Glu Ser Leu 
    1130                 1135                 1140             


Lys Gln  Lys Ile Lys Asn Ala  Ile Gln Lys Glu Thr  Glu Leu Leu 
    1145                 1150                 1155             


Tyr Glu  Tyr His Asp Lys Gly  Thr Ala Ile Ile Ser  Arg Asn Pro 
    1160                 1165                 1170             


Met Lys  Gly Gln Lys Glu Lys  Glu Glu Lys Asn Asn  Asp Ser Asn 
    1175                 1180                 1185             


Gly Leu  Pro Lys Gly Phe Cys  His Ala Val Gln Arg  Ser Phe Ile 
    1190                 1195                 1200             


Asp Tyr  Lys Asn Met Ile Leu  Gly Thr Ser Val Asn  Ile Tyr Glu 
    1205                 1210                 1215             


Tyr Ile  Gly Lys Leu Gln Glu  Asp Ile Lys Lys Ile  Ile Glu Lys 
    1220                 1225                 1230             


Gly Thr  Thr Lys Gln Asn Gly  Lys Thr Val Gly Ser  Gly Ala Glu 
    1235                 1240                 1245             


Asn Val  Asn Ala Trp Trp Lys  Gly Ile Glu Gly Glu  Met Trp Asp 
    1250                 1255                 1260             


Ala Val  Arg Cys Ala Ile Thr  Lys Ile Asn Lys Lys  Gln Lys Lys 
    1265                 1270                 1275             


Asn Gly  Thr Phe Ser Ile Asp  Glu Cys Gly Ile Phe  Pro Pro Thr 
    1280                 1285                 1290             


Gly Asn  Asp Glu Asp Gln Ser  Val Ser Trp Phe Lys  Glu Trp Ser 
    1295                 1300                 1305             


Glu Gln  Phe Cys Ile Glu Arg  Leu Gln Tyr Glu Lys  Asn Ile Arg 
    1310                 1315                 1320             


Asp Ala  Cys Thr Asn Asn Gly  Gln Gly Asp Lys Ile  Gln Gly Asp 
    1325                 1330                 1335             


Cys Lys  Arg Lys Cys Glu Glu  Tyr Lys Lys Tyr Ile  Ser Glu Lys 
    1340                 1345                 1350             


Lys Gln  Glu Trp Asp Lys Gln  Lys Thr Lys Tyr Glu  Asn Lys Tyr 
    1355                 1360                 1365             


Val Gly  Lys Ser Ala Ser Asp  Leu Leu Lys Glu Asn  Tyr Pro Glu 
    1370                 1375                 1380             


Cys Ile  Ser Ala Asn Phe Asp  Phe Ile Phe Asn Asp  Asn Ile Glu 
    1385                 1390                 1395             


Tyr Lys  Thr Tyr Tyr Pro Tyr  Gly Asp Tyr Ser Ser  Ile Cys Ser 
    1400                 1405                 1410             


Cys Glu  Gln Val Lys Tyr Tyr  Glu Tyr Asn Asn Ala  Glu Lys Lys 
    1415                 1420                 1425             


Asn Asn  Lys Ser Leu Cys His  Glu Lys Gly Asn Asp  Arg Thr Trp 
    1430                 1435                 1440             


Ser Lys  Lys Tyr Ile Lys Lys  Leu Glu Asn Gly Arg  Thr Leu Glu 
    1445                 1450                 1455             


Gly Val  Tyr Val Pro Pro Arg  Arg Gln Gln Leu Cys  Leu Tyr Glu 
    1460                 1465                 1470             


Leu Phe  Pro Ile Ile Ile Lys  Asn Lys Asn Asp Ile  Thr Asn Ala 
    1475                 1480                 1485             


Lys Lys  Glu Leu Leu Glu Thr  Leu Gln Ile Val Ala  Glu Arg Glu 
    1490                 1495                 1500             


Ala Tyr  Tyr Leu Trp Lys Gln  Tyr His Ala His Asn  Asp Thr Thr 
    1505                 1510                 1515             


Tyr Leu  Ala His Lys Lys Ala  Cys Cys Ala Ile Arg  Gly Ser Phe 
    1520                 1525                 1530             


Tyr Asp  Leu Glu Asp Ile Ile  Lys Gly Asn Asp Leu  Val His Asp 
    1535                 1540                 1545             


Glu Tyr  Thr Lys Tyr Ile Asp  Ser Lys Leu Asn Glu  Ile Phe Asp 
    1550                 1555                 1560             


Ser Ser  Asn Lys Asn Asp Ile  Glu Thr Lys Arg Ala  Arg Thr Asp 
    1565                 1570                 1575             


Trp Trp  Glu Asn Glu Ala Ile  Ala Val Pro Asn Ile  Thr Gly Ala 
    1580                 1585                 1590             


Asn Lys  Ser Asp Pro Lys Thr  Ile Arg Gln Leu Val  Trp Asp Ala 
    1595                 1600                 1605             


Met Gln  Ser Gly Val Arg Lys  Ala Ile Asp Glu Glu  Lys Glu Lys 
    1610                 1615                 1620             


Lys Lys  Pro Asn Glu Asn Phe  Pro Pro Cys Met Gly  Val Gln His 
    1625                 1630                 1635             


Ile Gly  Ile Ala Lys Pro Gln  Phe Ile Arg Trp Leu  Glu Glu Trp 
    1640                 1645                 1650             


Thr Asn  Glu Phe Cys Glu Lys  Tyr Thr Lys Tyr Phe  Glu Asp Met 
    1655                 1660                 1665             


Lys Ser  Asn Cys Asn Leu Arg  Lys Gly Ala Asp Asp  Cys Asp Asp 
    1670                 1675                 1680             


Asn Ser  Asn Ile Glu Cys Lys  Lys Ala Cys Ala Asn  Tyr Thr Asn 
    1685                 1690                 1695             


Trp Leu  Asn Pro Lys Arg Ile  Glu Trp Asn Gly Met  Ser Asn Tyr 
    1700                 1705                 1710             


Tyr Asn  Lys Ile Tyr Arg Lys  Ser Asn Lys Glu Ser  Glu Asp Gly 
    1715                 1720                 1725             


Lys Asp  Tyr Ser Met Ile Met  Glu Pro Thr Val Ile  Asp Tyr Leu 
    1730                 1735                 1740             


Asn Lys  Arg Cys Asn Gly Glu  Ile Asn Gly Asn Tyr  Ile Cys Cys 
    1745                 1750                 1755             


Ser Cys  Lys Asn Ile Gly Glu  Asn Ser Thr Ser Gly  Thr Val Asn 
    1760                 1765                 1770             


Lys Lys  Leu Gln Lys Lys Glu  Thr Gln Cys Glu Asp  Asn Lys Gly 
    1775                 1780                 1785             


Pro Leu  Asp Leu Met Asn Lys  Val Leu Asn Lys Met  Asp Pro Lys 
    1790                 1795                 1800             


Tyr Ser  Glu His 
    1805         


<210>  16
<211>  1808
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16

Met Asp Ser Thr Ser Thr Ile Ala Asn Lys Ile Glu Glu Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asp Asp Ser Lys Ile Asp Glu Leu Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Asp Pro Cys Glu Lys Lys Leu Pro Pro Tyr Asp Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Gly Lys Pro Glu Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Glu Arg Leu Cys Thr Tyr Asn Leu Glu Asn 
            100                 105                 110         


Leu Lys Phe Asp Lys Ile Arg Asp Asn Asn Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Lys Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Lys Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu 
            180                 185                 190         


Asn Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Lys Tyr Thr 
        195                 200                 205             


Lys Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly 
225                 230                 235                 240 


Trp Arg Thr Ser Gly Lys Ser Asp Arg Lys Lys Asn Phe Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Lys Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr 
        275                 280                 285             


Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser 
305                 310                 315                 320 


Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp 
                325                 330                 335     


Lys Thr Glu Trp Glu Asn Gln Glu Asn Lys Tyr Lys Asp Leu Tyr Glu 
            340                 345                 350         


Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp 
        355                 360                 365             


Tyr Val Lys Asp Phe Phe Glu Lys Leu Glu Ala Asn Tyr Ser Ser Leu 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Lys Ser 
385                 390                 395                 400 


Gly Thr Ser Arg Ser Lys Lys Lys Trp Ile Trp Lys Lys Ser Ser Gly 
                405                 410                 415     


Asn Glu Glu Gly Leu Gln Glu Glu Tyr Ala Asn Thr Ile Gly Leu Pro 
            420                 425                 430         


Pro Arg Thr Gln Ser Leu Tyr Leu Gly Asn Leu Pro Lys Leu Glu Asn 
        435                 440                 445             


Val Cys Glu Asp Val Lys Asp Ile Asn Phe Asp Thr Lys Glu Lys Phe 
    450                 455                 460                 


Leu Ala Gly Cys Leu Ile Val Ser Phe His Glu Gly Lys Asn Leu Lys 
465                 470                 475                 480 


Lys Arg Tyr Pro Gln Asn Lys Asn Ser Gly Asn Lys Glu Asn Leu Cys 
                485                 490                 495     


Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly 
            500                 505                 510         


Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu Leu Asn Leu 
        515                 520                 525             


Gln Asn Asn Phe Gly Lys Leu Phe Gly Lys Tyr Ile Lys Lys Asn Asn 
    530                 535                 540                 


Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu Leu Arg Glu 
545                 550                 555                 560 


Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Thr Ala Met Lys His 
                565                 570                 575     


Gly Ala Glu Met Asn Ile Thr Thr Cys Asn Ala Asp Gly Ser Val Thr 
            580                 585                 590         


Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro 
        595                 600                 605             


Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu Asn Phe Cys Glu Gln 
    610                 615                 620                 


Arg Gln Ala Lys Val Lys Asp Val Ile Thr Asn Cys Lys Ser Cys Lys 
625                 630                 635                 640 


Glu Ser Gly Asn Lys Cys Lys Thr Glu Cys Lys Thr Lys Cys Lys Asp 
                645                 650                 655     


Glu Cys Glu Lys Tyr Lys Lys Phe Ile Glu Ala Cys Gly Thr Ala Gly 
            660                 665                 670         


Gly Gly Ile Gly Thr Ala Gly Ser Pro Trp Ser Lys Arg Trp Asp Gln 
        675                 680                 685             


Ile Tyr Lys Arg Tyr Ser Lys His Ile Glu Asp Ala Lys Arg Asn Arg 
    690                 695                 700                 


Lys Ala Gly Thr Lys Asn Cys Gly Thr Ser Ser Thr Thr Asn Ala Ala 
705                 710                 715                 720 


Ala Ser Thr Asp Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe 
                725                 730                 735     


Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu 
            740                 745                 750         


Ser Asn Val Leu Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp 
        755                 760                 765             


Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Arg 
    770                 775                 780                 


Asp Lys Ser Lys Ser Gln Ser Ser Asp Thr Leu Val Val Val Asn Val 
785                 790                 795                 800 


Pro Ser Pro Leu Gly Asn Thr Pro Tyr Arg Tyr Lys Tyr Ala Cys Gln 
                805                 810                 815     


Cys Lys Ile Pro Thr Asn Glu Glu Thr Cys Asp Asp Arg Lys Glu Tyr 
            820                 825                 830         


Met Asn Gln Trp Ser Cys Gly Ser Ala Arg Thr Met Lys Arg Gly Tyr 
        835                 840                 845             


Lys Asn Asp Asn Tyr Glu Leu Cys Lys Tyr Asn Gly Val Asp Val Lys 
    850                 855                 860                 


Pro Thr Thr Val Arg Ser Asn Ser Ser Lys Leu Asp Gly Asn Asp Val 
865                 870                 875                 880 


Thr Phe Phe Asn Leu Phe Glu Gln Trp Asn Lys Glu Ile Gln Tyr Gln 
                885                 890                 895     


Ile Glu Gln Tyr Met Thr Asn Ala Asn Ile Ser Cys Ile Asp Glu Lys 
            900                 905                 910         


Glu Val Leu Asp Ser Val Ser Asp Glu Gly Thr Pro Lys Val Arg Gly 
        915                 920                 925             


Gly Tyr Glu Asp Gly Arg Asn Asn Asn Thr Asp Gln Gly Thr Asn Cys 
    930                 935                 940                 


Lys Glu Lys Cys Lys Cys Tyr Lys Leu Trp Ile Glu Lys Ile Asn Asp 
945                 950                 955                 960 


Gln Trp Gly Lys Gln Lys Asp Asn Tyr Asn Lys Phe Arg Ser Lys Gln 
                965                 970                 975     


Ile Tyr Asp Ala Asn Lys Gly Ser Gln Asn Lys Lys Val Val Ser Leu 
            980                 985                 990         


Ser Asn Phe Leu Phe Phe Ser Cys  Trp Glu Glu Tyr Ile  Gln Lys Tyr 
        995                 1000                 1005             


Phe Asn  Gly Asp Trp Ser Lys  Ile Lys Asn Ile Gly  Ser Asp Thr 
    1010                 1015                 1020             


Phe Glu  Phe Leu Ile Lys Lys  Cys Gly Asn Asn Ser  Ala His Gly 
    1025                 1030                 1035             


Glu Glu  Ile Phe Asn Glu Lys  Leu Lys Asn Ala Glu  Lys Lys Cys 
    1040                 1045                 1050             


Lys Glu  Asn Glu Ser Thr Asp  Thr Asn Ile Asn Lys  Ser Glu Thr 
    1055                 1060                 1065             


Ser Cys  Asp Leu Asn Ala Thr  Asn Tyr Ile Arg Gly  Cys Gln Ser 
    1070                 1075                 1080             


Lys Thr  Tyr Asp Gly Lys Ile  Phe Pro Gly Lys Gly  Gly Glu Lys 
    1085                 1090                 1095             


Gln Trp  Ile Cys Lys Asp Thr  Ile Ile His Gly Asp  Thr Asn Gly 
    1100                 1105                 1110             


Ala Cys  Ile Pro Pro Arg Thr  Gln Asn Leu Cys Val  Gly Glu Leu 
    1115                 1120                 1125             


Trp Asp  Lys Ser Tyr Gly Gly  Arg Ser Asn Ile Lys  Asn Asp Thr 
    1130                 1135                 1140             


Lys Glu  Leu Leu Lys Glu Lys  Ile Lys Asn Ala Ile  His Lys Glu 
    1145                 1150                 1155             


Thr Glu  Leu Leu Tyr Glu Tyr  His Asp Thr Gly Thr  Ala Ile Ile 
    1160                 1165                 1170             


Ser Lys  Asn Asp Lys Lys Gly  Gln Lys Gly Lys Asn  Asp Pro Asn 
    1175                 1180                 1185             


Gly Leu  Pro Lys Gly Phe Cys  His Ala Val Gln Arg  Ser Phe Ile 
    1190                 1195                 1200             


Asp Tyr  Lys Asn Met Ile Leu  Gly Thr Ser Val Asn  Ile Tyr Glu 
    1205                 1210                 1215             


His Ile  Gly Lys Leu Gln Glu  Asp Ile Lys Lys Ile  Ile Glu Lys 
    1220                 1225                 1230             


Gly Thr  Pro Gln Gln Lys Asp  Lys Ile Gly Gly Val  Gly Ser Ser 
    1235                 1240                 1245             


Thr Glu  Asn Val Asn Ala Trp  Trp Lys Gly Ile Glu  Arg Glu Met 
    1250                 1255                 1260             


Trp Asp  Ala Val Arg Cys Ala  Ile Thr Lys Ile Asn  Lys Lys Asn 
    1265                 1270                 1275             


Asn Asn  Ser Ile Phe Asn Gly  Asp Glu Cys Gly Val  Ser Pro Pro 
    1280                 1285                 1290             


Thr Gly  Asn Asp Glu Asp Gln  Ser Val Ser Trp Phe  Lys Glu Trp 
    1295                 1300                 1305             


Gly Glu  Gln Phe Cys Ile Glu  Arg Leu Arg Tyr Glu  Gln Asn Ile 
    1310                 1315                 1320             


Arg Glu  Ala Cys Thr Ile Asn  Gly Lys Asn Glu Lys  Lys Cys Ile 
    1325                 1330                 1335             


Asn Ser  Lys Ser Gly Gln Gly  Asp Lys Ile Gln Gly  Ala Cys Lys 
    1340                 1345                 1350             


Arg Lys  Cys Glu Lys Tyr Lys  Lys Tyr Ile Ser Glu  Lys Lys Gln 
    1355                 1360                 1365             


Glu Trp  Asp Lys Gln Lys Thr  Lys Tyr Glu Asn Lys  Tyr Val Gly 
    1370                 1375                 1380             


Lys Ser  Ala Ser Asp Leu Leu  Lys Glu Asn Tyr Pro  Glu Cys Ile 
    1385                 1390                 1395             


Ser Ala  Asn Phe Asp Phe Ile  Phe Asn Asp Asn Ile  Glu Tyr Lys 
    1400                 1405                 1410             


Thr Tyr  Tyr Pro Tyr Gly Asp  Tyr Ser Ser Ile Cys  Ser Cys Glu 
    1415                 1420                 1425             


Gln Val  Lys Tyr Tyr Lys Tyr  Asn Asn Ala Glu Lys  Lys Asn Asn 
    1430                 1435                 1440             


Lys Ser  Leu Cys Tyr Glu Lys  Asp Asn Asp Met Thr  Trp Ser Lys 
    1445                 1450                 1455             


Lys Tyr  Ile Lys Lys Leu Glu  Asn Gly Arg Ser Leu  Glu Gly Val 
    1460                 1465                 1470             


Tyr Val  Pro Pro Arg Arg Gln  Gln Leu Cys Leu Tyr  Glu Leu Phe 
    1475                 1480                 1485             


Pro Ile  Ile Ile Lys Asn Glu  Glu Gly Met Glu Lys  Ala Lys Glu 
    1490                 1495                 1500             


Glu Leu  Leu Glu Thr Leu Gln  Ile Val Ala Glu Arg  Glu Ala Tyr 
    1505                 1510                 1515             


Tyr Leu  Trp Lys Gln Tyr Asn  Pro Thr Gly Lys Gly  Ile Asp Asp 
    1520                 1525                 1530             


Ala Asn  Lys Lys Ala Cys Cys  Ala Ile Arg Gly Ser  Phe Tyr Asp 
    1535                 1540                 1545             


Leu Glu  Asp Ile Ile Lys Gly  Asn Asp Leu Val His  Asp Glu Tyr 
    1550                 1555                 1560             


Thr Lys  Tyr Ile Asp Ser Lys  Leu Asn Glu Ile Phe  Gly Ser Ser 
    1565                 1570                 1575             


Asp Thr  Asn Asp Ile Asp Thr  Lys Arg Ala Arg Thr  Asp Trp Trp 
    1580                 1585                 1590             


Glu Asn  Glu Thr Ile Thr Asn  Gly Thr Asp Arg Lys  Thr Ile Arg 
    1595                 1600                 1605             


Gln Leu  Val Trp Asp Ala Met  Gln Ser Gly Val Arg  Tyr Ala Val 
    1610                 1615                 1620             


Glu Glu  Lys Asn Glu Asn Phe  Pro Leu Cys Met Gly  Val Glu His 
    1625                 1630                 1635             


Ile Gly  Ile Ala Lys Pro Gln  Phe Ile Arg Trp Leu  Glu Glu Trp 
    1640                 1645                 1650             


Thr Asn  Glu Phe Cys Glu Lys  Tyr Thr Lys Tyr Phe  Glu Asp Met 
    1655                 1660                 1665             


Lys Ser  Lys Cys Asp Pro Pro  Lys Arg Ala Asp Thr  Cys Gly Asp 
    1670                 1675                 1680             


Asn Ser  Asn Ile Glu Cys Lys  Lys Ala Cys Ala Asn  Tyr Thr Asn 
    1685                 1690                 1695             


Trp Leu  Asn Pro Lys Arg Ile  Glu Trp Asn Gly Met  Ser Asn Tyr 
    1700                 1705                 1710             


Tyr Asn  Lys Ile Tyr Arg Lys  Ser Asn Lys Glu Ser  Glu Gly Gly 
    1715                 1720                 1725             


Lys Asp  Tyr Ser Met Ile Met  Ala Pro Thr Val Ile  Asp Tyr Leu 
    1730                 1735                 1740             


Asn Lys  Arg Cys His Gly Glu  Ile Asn Gly Asn Tyr  Ile Cys Cys 
    1745                 1750                 1755             


Ser Cys  Lys Asn Ile Gly Ala  Tyr Asn Thr Thr Ser  Gly Thr Val 
    1760                 1765                 1770             


Asn Lys  Lys Leu Gln Lys Lys  Glu Thr Glu Cys Glu  Glu Glu Lys 
    1775                 1780                 1785             


Gly Pro  Leu Asp Leu Met Asn  Glu Val Leu Asn Lys  Met Asp Lys 
    1790                 1795                 1800             


Lys Tyr  Ser Ala His 
    1805             


<210>  17
<211>  1455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17

Met Asp Lys Ser Ser Ile Ala Asn Lys Ile Glu Ala Tyr Leu Gly Ala 
1               5                   10                  15      


Lys Ser Asp Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Arg Lys 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
            100                 105                 110         


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
                165                 170                 175     


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
        195                 200                 205             


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
    210                 215                 220                 


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
225                 230                 235                 240 


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
                245                 250                 255     


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
            260                 265                 270         


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
        275                 280                 285             


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
    290                 295                 300                 


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
305                 310                 315                 320 


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
                325                 330                 335     


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
            340                 345                 350         


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
        355                 360                 365             


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
    370                 375                 380                 


Asn Tyr Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Ser Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
                405                 410                 415     


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
            420                 425                 430         


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
        435                 440                 445             


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
    450                 455                 460                 


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
465                 470                 475                 480 


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
                485                 490                 495     


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
            500                 505                 510         


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
        515                 520                 525             


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
    530                 535                 540                 


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
545                 550                 555                 560 


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
                565                 570                 575     


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly 
            580                 585                 590         


Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp 
        595                 600                 605             


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
    610                 615                 620                 


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys Lys 
625                 630                 635                 640 


Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Glu 
                645                 650                 655     


Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Asp Cys Lys 
            660                 665                 670         


Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln 
        675                 680                 685             


Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg 
    690                 695                 700                 


Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala 
705                 710                 715                 720 


Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu 
                725                 730                 735     


Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu 
            740                 745                 750         


Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr 
        755                 760                 765             


Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser Lys 
    770                 775                 780                 


Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu 
785                 790                 795                 800 


Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro 
                805                 810                 815     


Thr Asn Glu Glu Thr Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp 
            820                 825                 830         


Ser Cys Gly Ser Ala Arg Thr Met Lys Arg Gly Tyr Lys Asn Asp Asn 
        835                 840                 845             


Tyr Glu Leu Cys Lys Tyr Asn Gly Val Asp Val Lys Pro Thr Thr Val 
    850                 855                 860                 


Arg Ser Asn Ser Ser Lys Leu Asp Asp Lys Asp Val Thr Phe Phe Asn 
865                 870                 875                 880 


Leu Phe Glu Gln Trp Asn Lys Glu Ile Gln Tyr Gln Ile Glu Gln Tyr 
                885                 890                 895     


Met Thr Asn Thr Lys Ile Ser Cys Asn Asn Glu Lys Asn Val Leu Ser 
            900                 905                 910         


Arg Val Ser Asp Glu Ala Ala Gln Pro Lys Phe Ser Asp Asn Glu Arg 
        915                 920                 925             


Asp Arg Asn Ser Ile Thr His Glu Asp Lys Asn Cys Lys Glu Lys Cys 
    930                 935                 940                 


Lys Cys Tyr Ser Leu Trp Ile Glu Lys Ile Asn Asp Gln Trp Asp Lys 
945                 950                 955                 960 


Gln Lys Asp Asn Tyr Asn Lys Phe Gln Arg Lys Gln Ile Tyr Asp Ala 
                965                 970                 975     


Asn Lys Gly Ser Gln Asn Lys Lys Val Val Ser Leu Ser Asn Phe Leu 
            980                 985                 990         


Phe Phe Ser Cys Trp Glu Glu Tyr  Ile Gln Lys Tyr Phe  Asn Gly Asp 
        995                 1000                 1005             


Trp Ser  Lys Ile Lys Asn Ile  Gly Ser Asp Thr Phe  Glu Phe Leu 
    1010                 1015                 1020             


Ile Lys  Lys Cys Gly Asn Asp  Ser Gly Asp Gly Glu  Thr Ile Phe 
    1025                 1030                 1035             


Ser Glu  Lys Leu Asn Asn Ala  Glu Lys Lys Cys Lys  Glu Asn Glu 
    1040                 1045                 1050             


Ser Thr  Asn Asn Lys Met Lys  Ser Ser Glu Thr Ser  Gly Ser Gly 
    1055                 1060                 1065             


Ser Gly  Ala Glu Lys Lys Asn  Asn Lys Ser Leu Cys  His Glu Lys 
    1070                 1075                 1080             


Gly Asn  Asp Arg Thr Trp Ser  Lys Lys Tyr Ile Lys  Lys Leu Glu 
    1085                 1090                 1095             


Asn Gly  Arg Thr Leu Glu Gly  Val Tyr Val Pro Pro  Arg Arg Gln 
    1100                 1105                 1110             


Gln Leu  Cys Leu Tyr Glu Leu  Phe Pro Ile Ile Ile  Lys Asn Lys 
    1115                 1120                 1125             


Asn Asp  Ile Thr Asn Ala Lys  Lys Glu Leu Leu Glu  Thr Leu Gln 
    1130                 1135                 1140             


Ile Val  Ala Glu Arg Glu Ala  Tyr Tyr Leu Trp Lys  Gln Tyr His 
    1145                 1150                 1155             


Ala His  Asn Asp Thr Thr Tyr  Leu Ala His Lys Lys  Ala Cys Cys 
    1160                 1165                 1170             


Ala Ile  Arg Gly Ser Phe Tyr  Asp Leu Glu Asp Ile  Ile Lys Gly 
    1175                 1180                 1185             


Asn Asp  Leu Val His Asp Glu  Tyr Thr Lys Tyr Ile  Asp Ser Lys 
    1190                 1195                 1200             


Leu Asn  Glu Ile Phe Asp Ser  Ser Asn Lys Asn Asp  Ile Glu Thr 
    1205                 1210                 1215             


Lys Arg  Ala Arg Thr Asp Trp  Trp Glu Asn Glu Ala  Ile Ala Val 
    1220                 1225                 1230             


Pro Asn  Ile Thr Gly Ala Asn  Lys Ser Asp Pro Lys  Thr Ile Arg 
    1235                 1240                 1245             


Gln Leu  Val Trp Asp Ala Met  Gln Ser Gly Val Arg  Lys Ala Ile 
    1250                 1255                 1260             


Asp Glu  Glu Lys Glu Lys Lys  Lys Pro Asn Glu Asn  Phe Pro Pro 
    1265                 1270                 1275             


Cys Met  Gly Val Gln His Ile  Gly Ile Ala Lys Pro  Gln Phe Ile 
    1280                 1285                 1290             


Arg Trp  Leu Glu Glu Trp Thr  Asn Glu Phe Cys Glu  Lys Tyr Thr 
    1295                 1300                 1305             


Lys Tyr  Phe Glu Asp Met Lys  Ser Asn Cys Asn Leu  Arg Lys Gly 
    1310                 1315                 1320             


Ala Asp  Asp Cys Asp Asp Asn  Ser Asn Ile Glu Cys  Lys Lys Ala 
    1325                 1330                 1335             


Cys Ala  Asn Tyr Thr Asn Trp  Leu Asn Pro Lys Arg  Ile Glu Trp 
    1340                 1345                 1350             


Asn Gly  Met Ser Asn Tyr Tyr  Asn Lys Ile Tyr Arg  Lys Ser Asn 
    1355                 1360                 1365             


Lys Glu  Ser Glu Asp Gly Lys  Asp Tyr Ser Met Ile  Met Glu Pro 
    1370                 1375                 1380             


Thr Val  Ile Asp Tyr Leu Asn  Lys Arg Cys Asn Gly  Glu Ile Asn 
    1385                 1390                 1395             


Gly Asn  Tyr Ile Cys Cys Ser  Cys Lys Asn Ile Gly  Glu Asn Ser 
    1400                 1405                 1410             


Thr Ser  Gly Thr Val Asn Lys  Lys Leu Gln Lys Lys  Glu Thr Gln 
    1415                 1420                 1425             


Cys Glu  Asp Asn Lys Gly Pro  Leu Asp Leu Met Asn  Lys Val Leu 
    1430                 1435                 1440             


Asn Lys  Met Asp Pro Lys Tyr  Ser Glu His Lys Met  
    1445                 1450                 1455 


<210>  18
<211>  1447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18

Met Asp Ser Thr Ser Thr Ile Ala Asn Lys Ile Glu Glu Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asp Asp Ser Lys Ile Asp Glu Leu Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Asp Pro Cys Glu Lys Lys Leu Pro Pro Tyr Asp Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Gly Lys Pro Glu Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Glu Arg Leu Cys Thr Tyr Asn Leu Glu Asn 
            100                 105                 110         


Leu Lys Phe Asp Lys Ile Arg Asp Asn Asn Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Lys Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Lys Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu 
            180                 185                 190         


Asn Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Lys Tyr Thr 
        195                 200                 205             


Lys Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly 
225                 230                 235                 240 


Trp Arg Thr Ser Gly Lys Ser Asp Arg Lys Lys Asn Phe Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Lys Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr 
        275                 280                 285             


Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser 
305                 310                 315                 320 


Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp 
                325                 330                 335     


Lys Thr Glu Trp Glu Asn Gln Glu Asn Lys Tyr Lys Asp Leu Tyr Glu 
            340                 345                 350         


Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp 
        355                 360                 365             


Tyr Val Lys Asp Phe Phe Glu Lys Leu Glu Ala Asn Tyr Ser Ser Leu 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Lys Ser 
385                 390                 395                 400 


Gly Thr Ser Arg Ser Lys Lys Lys Trp Ile Trp Lys Lys Ser Ser Gly 
                405                 410                 415     


Asn Glu Glu Gly Leu Gln Glu Glu Tyr Ala Asn Thr Ile Gly Leu Pro 
            420                 425                 430         


Pro Arg Thr Gln Ser Leu Tyr Leu Gly Asn Leu Pro Lys Leu Glu Asn 
        435                 440                 445             


Val Cys Glu Asp Val Lys Asp Ile Asn Phe Asp Thr Lys Glu Lys Phe 
    450                 455                 460                 


Leu Ala Gly Cys Leu Ile Val Ser Phe His Glu Gly Lys Asn Leu Lys 
465                 470                 475                 480 


Lys Arg Tyr Pro Gln Asn Lys Asn Ser Gly Asn Lys Glu Asn Leu Cys 
                485                 490                 495     


Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly 
            500                 505                 510         


Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu Leu Asn Leu 
        515                 520                 525             


Gln Asn Asn Phe Gly Lys Leu Phe Gly Lys Tyr Ile Lys Lys Asn Asn 
    530                 535                 540                 


Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu Leu Arg Glu 
545                 550                 555                 560 


Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Thr Ala Met Lys His 
                565                 570                 575     


Gly Ala Glu Met Asn Ile Thr Thr Cys Asn Ala Asp Gly Ser Val Thr 
            580                 585                 590         


Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro 
        595                 600                 605             


Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu Asn Phe Cys Glu Gln 
    610                 615                 620                 


Arg Gln Ala Lys Val Lys Asp Val Ile Thr Asn Cys Lys Ser Cys Lys 
625                 630                 635                 640 


Glu Ser Gly Asn Lys Cys Lys Thr Glu Cys Lys Thr Lys Cys Lys Asp 
                645                 650                 655     


Glu Cys Glu Lys Tyr Lys Lys Phe Ile Glu Ala Cys Gly Thr Ala Gly 
            660                 665                 670         


Gly Gly Ile Gly Thr Ala Gly Ser Pro Trp Ser Lys Arg Trp Asp Gln 
        675                 680                 685             


Ile Tyr Lys Arg Tyr Ser Lys His Ile Glu Asp Ala Lys Arg Asn Arg 
    690                 695                 700                 


Lys Ala Gly Thr Lys Asn Cys Gly Thr Ser Ser Thr Thr Asn Ala Ala 
705                 710                 715                 720 


Ala Ser Thr Asp Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe 
                725                 730                 735     


Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu 
            740                 745                 750         


Ser Asn Val Leu Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp 
        755                 760                 765             


Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Arg 
    770                 775                 780                 


Asp Lys Ser Lys Ser Gln Ser Ser Asp Thr Leu Val Val Val Asn Val 
785                 790                 795                 800 


Pro Ser Pro Leu Gly Asn Thr Pro Tyr Arg Tyr Lys Tyr Ala Cys Gln 
                805                 810                 815     


Cys Lys Ile Pro Thr Asn Glu Glu Thr Cys Asp Asp Arg Lys Glu Tyr 
            820                 825                 830         


Met Asn Gln Trp Ser Cys Gly Ser Ala Arg Thr Met Lys Arg Gly Tyr 
        835                 840                 845             


Lys Asn Asp Asn Tyr Glu Leu Cys Lys Tyr Asn Gly Val Asp Val Lys 
    850                 855                 860                 


Pro Thr Thr Val Arg Ser Asn Ser Ser Lys Leu Asp Gly Asn Asp Val 
865                 870                 875                 880 


Thr Phe Phe Asn Leu Phe Glu Gln Trp Asn Lys Glu Ile Gln Tyr Gln 
                885                 890                 895     


Ile Glu Gln Tyr Met Thr Asn Ala Asn Ile Ser Cys Ile Asp Glu Lys 
            900                 905                 910         


Glu Val Leu Asp Ser Val Ser Asp Glu Gly Thr Pro Lys Val Arg Gly 
        915                 920                 925             


Gly Tyr Glu Asp Gly Arg Asn Asn Asn Thr Asp Gln Gly Thr Asn Cys 
    930                 935                 940                 


Lys Glu Lys Cys Lys Cys Tyr Lys Leu Trp Ile Glu Lys Ile Asn Asp 
945                 950                 955                 960 


Gln Trp Gly Lys Gln Lys Asp Asn Tyr Asn Lys Phe Arg Ser Lys Gln 
                965                 970                 975     


Ile Tyr Asp Ala Asn Lys Gly Ser Gln Asn Lys Lys Val Val Ser Leu 
            980                 985                 990         


Ser Asn Phe Leu Phe Phe Ser Cys  Trp Glu Glu Tyr Ile  Gln Lys Tyr 
        995                 1000                 1005             


Phe Asn  Gly Asp Trp Ser Lys  Ile Lys Asn Ile Gly  Ser Asp Thr 
    1010                 1015                 1020             


Phe Glu  Phe Leu Ile Lys Lys  Cys Gly Asn Asn Ser  Ala His Gly 
    1025                 1030                 1035             


Glu Glu  Ile Phe Asn Glu Lys  Leu Lys Asn Ala Glu  Lys Lys Cys 
    1040                 1045                 1050             


Lys Glu  Asn Glu Ser Thr Asp  Thr Asn Ile Asn Lys  Ser Glu Thr 
    1055                 1060                 1065             


Ser Gly  Ser Gly Ser Gly Ala  Glu Lys Lys Asn Asn  Lys Ser Leu 
    1070                 1075                 1080             


Cys Tyr  Glu Lys Asp Asn Asp  Met Thr Trp Ser Lys  Lys Tyr Ile 
    1085                 1090                 1095             


Lys Lys  Leu Glu Asn Gly Arg  Ser Leu Glu Gly Val  Tyr Val Pro 
    1100                 1105                 1110             


Pro Arg  Arg Gln Gln Leu Cys  Leu Tyr Glu Leu Phe  Pro Ile Ile 
    1115                 1120                 1125             


Ile Lys  Asn Glu Glu Gly Met  Glu Lys Ala Lys Glu  Glu Leu Leu 
    1130                 1135                 1140             


Glu Thr  Leu Gln Ile Val Ala  Glu Arg Glu Ala Tyr  Tyr Leu Trp 
    1145                 1150                 1155             


Lys Gln  Tyr Asn Pro Thr Gly  Lys Gly Ile Asp Asp  Ala Asn Lys 
    1160                 1165                 1170             


Lys Ala  Cys Cys Ala Ile Arg  Gly Ser Phe Tyr Asp  Leu Glu Asp 
    1175                 1180                 1185             


Ile Ile  Lys Gly Asn Asp Leu  Val His Asp Glu Tyr  Thr Lys Tyr 
    1190                 1195                 1200             


Ile Asp  Ser Lys Leu Asn Glu  Ile Phe Gly Ser Ser  Asp Thr Asn 
    1205                 1210                 1215             


Asp Ile  Asp Thr Lys Arg Ala  Arg Thr Asp Trp Trp  Glu Asn Glu 
    1220                 1225                 1230             


Thr Ile  Thr Asn Gly Thr Asp  Arg Lys Thr Ile Arg  Gln Leu Val 
    1235                 1240                 1245             


Trp Asp  Ala Met Gln Ser Gly  Val Arg Tyr Ala Val  Glu Glu Lys 
    1250                 1255                 1260             


Asn Glu  Asn Phe Pro Leu Cys  Met Gly Val Glu His  Ile Gly Ile 
    1265                 1270                 1275             


Ala Lys  Pro Gln Phe Ile Arg  Trp Leu Glu Glu Trp  Thr Asn Glu 
    1280                 1285                 1290             


Phe Cys  Glu Lys Tyr Thr Lys  Tyr Phe Glu Asp Met  Lys Ser Lys 
    1295                 1300                 1305             


Cys Asp  Pro Pro Lys Arg Ala  Asp Thr Cys Gly Asp  Asn Ser Asn 
    1310                 1315                 1320             


Ile Glu  Cys Lys Lys Ala Cys  Ala Asn Tyr Thr Asn  Trp Leu Asn 
    1325                 1330                 1335             


Pro Lys  Arg Ile Glu Trp Asn  Gly Met Ser Asn Tyr  Tyr Asn Lys 
    1340                 1345                 1350             


Ile Tyr  Arg Lys Ser Asn Lys  Glu Ser Glu Gly Gly  Lys Asp Tyr 
    1355                 1360                 1365             


Ser Met  Ile Met Ala Pro Thr  Val Ile Asp Tyr Leu  Asn Lys Arg 
    1370                 1375                 1380             


Cys His  Gly Glu Ile Asn Gly  Asn Tyr Ile Cys Cys  Ser Cys Lys 
    1385                 1390                 1395             


Asn Ile  Gly Ala Tyr Asn Thr  Thr Ser Gly Thr Val  Asn Lys Lys 
    1400                 1405                 1410             


Leu Gln  Lys Lys Glu Thr Glu  Cys Glu Glu Glu Lys  Gly Pro Leu 
    1415                 1420                 1425             


Asp Leu  Met Asn Glu Val Leu  Asn Lys Met Asp Lys  Lys Tyr Ser 
    1430                 1435                 1440             


Ala His  Lys Met 
    1445         


<210>  19
<211>  1975
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19

Met Asp Lys Ser Ser Ile Gly Asp Lys Ile Glu Glu Tyr Leu Lys Glu 
1               5                   10                  15      


Lys Ser Asp Asp Ser Lys Ile Asp Glu Leu Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Lys Asn 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr Glu 
    50                  55                  60                  


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Gln Gln Asn Leu Tyr Lys Ala Ser Glu Asn Asn Lys Asn Val Phe 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Asn Leu 
            100                 105                 110         


Asn Val Glu Arg Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Ile Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Ile Ala Asp Ile Ile Arg Gly Arg Asp Gly Asn Lys Cys Glu Thr Lys 
                165                 170                 175     


Ser Thr Asn Asn Val Glu Glu Leu Ile Lys Lys Phe Phe Glu Lys Asn 
            180                 185                 190         


Tyr Arg Glu Asn Lys Glu Tyr Lys Arg Lys Tyr Pro Asn Asp Asp Pro 
        195                 200                 205             


Lys Tyr Thr Lys Leu Arg Glu Asp Trp Trp Thr Lys Asn Arg Gln Lys 
    210                 215                 220                 


Val Trp Glu Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile 
225                 230                 235                 240 


Lys Arg Gly Trp Thr Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys Leu 
                245                 250                 255     


Glu Leu Cys Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys 
            260                 265                 270         


Leu Asp Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu 
        275                 280                 285             


Asp Leu Tyr Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His 
    290                 295                 300                 


Arg Glu Glu Cys Thr Ser Glu Asp His Lys Ser Lys Glu Gly Ala Ser 
305                 310                 315                 320 


Tyr Cys Asn Met Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val 
                325                 330                 335     


Lys Lys Trp Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Lys Asp 
            340                 345                 350         


Leu Tyr Gln Gln Glu Asn Glu Thr Ser Ser Ser Ser Lys Lys Lys Ser 
        355                 360                 365             


Arg Tyr Asp Asp Tyr Val Lys Glu Phe Phe Lys Lys Leu Asn Glu Ala 
    370                 375                 380                 


Asn Tyr Ser Ser Leu Glu Asn Tyr Ile Lys Asp Asp Pro Tyr Ser Lys 
385                 390                 395                 400 


Glu Tyr Val Thr Lys Leu Ser Phe Ile Pro Asn Ser Ser Asp Ala Asn 
                405                 410                 415     


Thr Ser Ser Glu Lys Ile Gln Lys Asn Asn Asp Glu Val Cys Asn Pro 
            420                 425                 430         


Asn Glu Ser Gly Ile Ser Ser Val Glu Gln Ala Gln Thr Ser Gly Pro 
        435                 440                 445             


Ser Ser Asn Lys Thr Cys Ile Thr His Ser Ser Ile Lys Ala Asn Lys 
    450                 455                 460                 


Lys Lys Glu Cys Lys Asp Val Lys Leu Gly Val Arg Glu Asn Asp Lys 
465                 470                 475                 480 


Asp Leu Lys Ile Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp 
                485                 490                 495     


Asn Cys Cys Cys Gln Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser 
            500                 505                 510         


Asp Asn Lys Arg Gly Ser Ser Ser Asn Asp Ser Cys Asp Asn Lys Asn 
        515                 520                 525             


Gln Asp Glu Cys Gln Lys Lys Leu Asp Glu Ala Leu Glu Ser Leu His 
    530                 535                 540                 


Asn Gly Tyr Lys Asn Gln Lys Cys Lys Ser Gly Thr Ser Thr Val Asn 
545                 550                 555                 560 


Lys Lys Trp Ile Trp Lys Lys Ser Ser Gly Asn Lys Glu Gly Leu Gln 
                565                 570                 575     


Lys Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu 
            580                 585                 590         


Tyr Leu Gly Asn Leu Pro Lys Leu Glu Asn Val Ser Lys Gly Val Thr 
        595                 600                 605             


Asp Ile Ile Tyr Asp Thr Lys Glu Lys Phe Leu Ala Gly Cys Leu Ile 
    610                 615                 620                 


Val Ser Phe His Glu Gly Lys Asn Leu Lys Thr Ser His Glu Lys Lys 
625                 630                 635                 640 


Asn Asp Asp Asn Gly Lys Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe 
                645                 650                 655     


Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu 
            660                 665                 670         


Tyr Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ala Phe Gly Lys Leu 
        675                 680                 685             


Phe Arg Lys Tyr Ile Lys Lys Asn Ile Ser Ala Glu Gln Asp Thr Ser 
    690                 695                 700                 


Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys 
705                 710                 715                 720 


Lys Tyr Ile Trp Ile Ala Met Lys His Gly Ala Gly Met Asn Gly Thr 
                725                 730                 735     


Thr Cys Cys Gly Asp Gly Ser Ser Gly Glu Asn Gln Thr Asn Ser Cys 
            740                 745                 750         


Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu 
        755                 760                 765             


Gln Glu Trp Val Glu His Phe Cys Glu Gln Arg Gln Ala Lys Val Lys 
    770                 775                 780                 


Asp Val Ile Thr Asn Cys Lys Ser Cys Lys Asn Thr Ser Gly Glu Arg 
785                 790                 795                 800 


Lys Ile Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Lys Cys Lys Asn 
                805                 810                 815     


Lys Cys Glu Ala Tyr Lys Thr Phe Ile Glu His Cys Lys Gly Gly Asp 
            820                 825                 830         


Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln Ile Tyr Lys 
        835                 840                 845             


Arg Tyr Ser Lys His Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly 
    850                 855                 860                 


Thr Lys Ser Cys Gly Thr Ser Thr Ala Glu Asn Lys Cys Val Gln Ser 
865                 870                 875                 880 


Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr 
                885                 890                 895     


Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp Glu Asn Asn Cys Gly Glu 
            900                 905                 910         


Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Thr Lys Asn Cys Asp Ile 
        915                 920                 925             


Gln Lys Asp Lys Ser Lys Ser Gln Ser Ser Asp Thr Leu Val Val Val 
    930                 935                 940                 


Asn Val Pro Ser Pro Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala 
945                 950                 955                 960 


Cys Gln Cys Lys Ile Pro Thr Thr Glu Glu Thr Cys Asp Asp Arg Lys 
                965                 970                 975     


Glu Tyr Met Asn Gln Trp Ser Cys Gly Ser Ala Arg Thr Met Lys Arg 
            980                 985                 990         


Gly Tyr Lys Asn Asp Asn Tyr Glu  Leu Cys Lys Tyr Asn  Gly Val Asp 
        995                 1000                 1005             


Val Lys  Pro Thr Thr Val Arg  Ser Ser Ser Thr Lys  Leu Asp Gly 
    1010                 1015                 1020             


Asn Asp  Val Met Phe Phe Asn  Leu Phe Glu Gln Trp  Asn Lys Glu 
    1025                 1030                 1035             


Ile Gln  Tyr Gln Ile Glu Gln  Tyr Met Thr Asn Ala  Asn Ile Ser 
    1040                 1045                 1050             


Cys Asn  Asn Glu Met Lys Val  Leu Ser Ser Ser Ser  Glu Glu Ser 
    1055                 1060                 1065             


Gln Asn  Gln Asn Gly Ser Asp  His His Asp Gly Arg  Asn Asn Asn 
    1070                 1075                 1080             


Thr Asp  Gln Ser Thr Asn Cys  Lys Glu Lys Cys Glu  Cys Tyr Lys 
    1085                 1090                 1095             


Leu Trp  Ile Glu Lys Ile Lys  Lys Gln Trp Gly Lys  Gln Lys Asn 
    1100                 1105                 1110             


Asn Tyr  Asn Lys Phe Arg Ser  Lys Gln Ile Tyr Asp  Ala Asn Lys 
    1115                 1120                 1125             


Gly Pro  Gln Asn Lys Lys Val  Val Ser Leu Ser His  Phe Leu Phe 
    1130                 1135                 1140             


Phe Ser  Cys Trp Glu Glu Tyr  Ile Gln Lys Gln Phe  Asn Gly Asp 
    1145                 1150                 1155             


Trp Ser  Lys Ile Lys Asn Ile  Gly Ser Asp Thr Phe  Glu Phe Leu 
    1160                 1165                 1170             


Ile Lys  Lys Cys Gly Asn Asn  Ser Gly Asp Gly Glu  Thr Ile Phe 
    1175                 1180                 1185             


Asn Lys  Lys Leu Lys Asn Ala  Glu Lys Lys Cys Lys  Glu Asn Glu 
    1190                 1195                 1200             


Ser Thr  Asp Thr Lys Met Lys  Ser Ser Glu Thr Ser  Cys Asp Leu 
    1205                 1210                 1215             


Asn Ala  Thr Asn Tyr Ile Arg  Gly Cys Gln Ser Lys  Thr Tyr Asp 
    1220                 1225                 1230             


Gly Lys  Ile Phe Pro Gly Lys  Gly Gly Glu Lys Gln  Trp Ile Cys 
    1235                 1240                 1245             


Lys Asp  Thr Ile Ile His Gly  Asp Thr Asn Gly Ala  Cys Ile Pro 
    1250                 1255                 1260             


Pro Arg  Thr Gln Asn Leu Cys  Val Gly Asn Leu Trp  Asp Lys Ser 
    1265                 1270                 1275             


Tyr Gly  Gly Arg Ser Asn Ile  Lys Asn Asp Thr Lys  Glu Ser Leu 
    1280                 1285                 1290             


Lys Asn  Lys Leu Lys Asn Ala  Ile Gln Lys Glu Thr  Glu Leu Leu 
    1295                 1300                 1305             


Tyr Glu  Tyr His Asp Lys Gly  Thr Ala Ile Ile Ser  Arg Asn Pro 
    1310                 1315                 1320             


Met Lys  Glu Gly Gly Glu Asp  Gly Lys Gly Lys Gln  Lys Glu Gly 
    1325                 1330                 1335             


Gly Glu  Glu Ala Asn Asn Asn  Ser Asn Gly Leu Pro  Lys Gly Phe 
    1340                 1345                 1350             


Cys His  Ala Val Gln Arg Ser  Phe Ile Asp Tyr Lys  Asn Met Ile 
    1355                 1360                 1365             


Leu Gly  Thr Ser Val Asn Thr  Tyr Glu Tyr Ile Gly  Lys Leu Gln 
    1370                 1375                 1380             


Glu Asp  Ile Lys Lys Ile Ile  Glu Lys Gly Thr Pro  Gln Gln Lys 
    1385                 1390                 1395             


Asp Lys  Ile Gly Gly Val Gly  Ser Ser Thr Glu Asn  Val Asn Ala 
    1400                 1405                 1410             


Trp Trp  Lys Gly Ile Glu Gly  Glu Met Trp Asp Ala  Val Arg Cys 
    1415                 1420                 1425             


Ala Ile  Thr Lys Ile Lys Lys  Gln Lys Lys Asn Gly  Thr Phe Asn 
    1430                 1435                 1440             


Gly Asp  Glu Cys Gly Val Ser  Pro Pro Thr Gly Asn  Asp Glu Asp 
    1445                 1450                 1455             


Gln Phe  Val Ser Trp Phe Lys  Glu Trp Gly Glu Gln  Phe Cys Ile 
    1460                 1465                 1470             


Glu Arg  Leu Arg Tyr Glu Gln  Asn Ile Arg Glu Ala  Cys Thr Ile 
    1475                 1480                 1485             


Asn Gly  Lys Asn Glu Lys Lys  Cys Ile Asn Ser Lys  Ser Gly Gln 
    1490                 1495                 1500             


Gly Asp  Lys Ile Gln Gly Ala  Cys Lys Arg Lys Cys  Glu Lys Tyr 
    1505                 1510                 1515             


Lys Lys  Tyr Ile Ser Glu Lys  Lys Gln Glu Trp Asp  Lys Gln Lys 
    1520                 1525                 1530             


Thr Lys  Tyr Glu Asn Lys Tyr  Val Gly Lys Ser Ala  Ser Asp Leu 
    1535                 1540                 1545             


Leu Lys  Glu Asn Tyr Pro Glu  Cys Ile Ser Ala Asn  Phe Asp Phe 
    1550                 1555                 1560             


Ile Phe  Asn Asp Asn Ile Glu  Tyr Lys Thr Tyr Tyr  Pro Tyr Gly 
    1565                 1570                 1575             


Asp Tyr  Ser Ser Ile Cys Ser  Cys Glu Gln Val Lys  Tyr Tyr Lys 
    1580                 1585                 1590             


Tyr Asn  Asn Ala Glu Lys Lys  Asn Asn Lys Ser Leu  Cys His Glu 
    1595                 1600                 1605             


Lys Gly  Asn Asp Arg Thr Trp  Ser Lys Lys Tyr Ile  Lys Lys Leu 
    1610                 1615                 1620             


Glu Asn  Gly Arg Thr Leu Glu  Gly Val Tyr Val Pro  Pro Arg Arg 
    1625                 1630                 1635             


Gln Gln  Leu Cys Leu Tyr Glu  Leu Phe Pro Ile Ile  Ile Lys Asn 
    1640                 1645                 1650             


Lys Asn  Asp Ile Thr Asn Ala  Lys Glu Glu Leu Leu  Glu Thr Leu 
    1655                 1660                 1665             


Gln Ile  Val Ala Glu Arg Glu  Ala Tyr Tyr Leu Trp  Lys Gln Tyr 
    1670                 1675                 1680             


Asn Pro  Thr Gly Lys Gly Ile  Asp Asp Ala Asn Lys  Lys Ala Cys 
    1685                 1690                 1695             


Cys Ala  Ile Arg Gly Ser Phe  Tyr Asp Leu Glu Asp  Ile Ile Lys 
    1700                 1705                 1710             


Gly Asn  Asp Leu Val His Asp  Glu Tyr Thr Lys Tyr  Ile Asp Ser 
    1715                 1720                 1725             


Lys Leu  Asn Glu Ile Phe Gly  Ser Ser Asn Lys Asn  Asp Ile Glu 
    1730                 1735                 1740             


Thr Lys  Arg Ala Arg Thr Asp  Trp Trp Glu Asn Glu  Thr Ile Thr 
    1745                 1750                 1755             


Asn Gly  Thr Asp Arg Lys Thr  Ile Arg Gln Leu Val  Trp Asp Ala 
    1760                 1765                 1770             


Met Gln  Ser Gly Val Arg Lys  Ala Ile Asp Glu Glu  Lys Glu Lys 
    1775                 1780                 1785             


Lys Lys  Pro Asn Glu Asn Phe  Pro Pro Cys Met Gly  Val Glu His 
    1790                 1795                 1800             


Ile Gly  Ile Ala Lys Pro Gln  Phe Ile Arg Trp Leu  Glu Glu Trp 
    1805                 1810                 1815             


Thr Asn  Glu Phe Cys Glu Glu  Tyr Thr Lys Tyr Phe  Glu Asp Met 
    1820                 1825                 1830             


Lys Ser  Asn Cys Asn Arg Arg  Lys Gly Ala Asp Asp  Cys Gly Asp 
    1835                 1840                 1845             


Asn Thr  Asn Ile Glu Cys Lys  Lys Ala Cys Ala Asn  Tyr Thr Asn 
    1850                 1855                 1860             


Trp Leu  Asn Pro Lys Arg Ile  Glu Trp Asn Gly Met  Ser Asn Tyr 
    1865                 1870                 1875             


Tyr Asn  Lys Ile Tyr Arg Lys  Ser Asn Lys Glu Ser  Glu Asp Gly 
    1880                 1885                 1890             


Lys Asp  Tyr Ser Met Ile Met  Glu Pro Thr Val Ile  Asp Tyr Leu 
    1895                 1900                 1905             


Asn Lys  Arg Cys Asn Gly Glu  Ile Asn Gly Asn Tyr  Ile Cys Cys 
    1910                 1915                 1920             


Ser Cys  Lys Asn Ile Gly Ala  Tyr Asn Thr Thr Ser  Gly Thr Val 
    1925                 1930                 1935             


Asn Lys  Lys Leu Gln Lys Lys  Glu Thr Glu Cys Glu  Asp Asn Lys 
    1940                 1945                 1950             


Gly Pro  Leu Asp Leu Met Asn  Glu Val Leu Asn Lys  Met Asp Glu 
    1955                 1960                 1965             


Lys Tyr  Ser Lys Leu Asn Leu  
    1970                 1975 


<210>  20
<211>  1980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20

Met Asp Ser Thr Ser Thr Ile Gly Asp Lys Ile Glu Ala Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asn Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Lys Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn 
    50                  55                  60                  


Asp Pro Cys Glu Lys Lys Glu Leu Ser Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Asn Asn Lys Asn Ile 
                85                  90                  95      


Phe Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Lys 
            100                 105                 110         


Leu Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Ile Leu Tyr His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Ile Ala Asp Ile Ile Arg Gly Thr Asp Gln Leu Lys Gly Ser Asn 
                165                 170                 175     


Ile Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Lys 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Pro Asn Asp Asp Glu Asn Tyr Lys 
        195                 200                 205             


Lys Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Arg 
225                 230                 235                 240 


Trp Thr Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys Leu Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Leu Tyr 
        275                 280                 285             


Arg Glu Glu Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Lys Asn Val Glu Ser Asn Glu Gly Ala Ser Tyr Cys Asn 
305                 310                 315                 320 


Met Cys Lys Glu Lys His Thr Lys Tyr Cys Glu Cys Val Lys Lys Trp 
                325                 330                 335     


Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Glu 
            340                 345                 350         


Gln Glu Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
        355                 360                 365             


Val Lys Asp Phe Phe Glu Lys Leu Lys Gly Asn Gly Tyr Ser Ser Ala 
    370                 375                 380                 


Asn Ser Tyr Val Lys Asp Asp Pro Tyr Ser Ala Glu Tyr Val Thr Lys 
385                 390                 395                 400 


Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Thr Ser Ser Glu Thr 
                405                 410                 415     


Pro Ser Lys Tyr Tyr Asp Glu Val Cys Asn Cys Asn Glu Ser Glu Ile 
            420                 425                 430         


Ser Ser Val Gly Gln Ala Gln Thr Ser Gly Pro Ser Ser Asn Lys Thr 
        435                 440                 445             


Cys Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Val Cys Lys 
    450                 455                 460                 


Asp Val Lys Leu Gly Ile Asn Asn Asn Asp Lys Val Leu Arg Val Cys 
465                 470                 475                 480 


Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys Gln 
                485                 490                 495     


Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Lys Asn Gln Ser 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Asp Glu Cys 
        515                 520                 525             


Gln Lys Lys Leu Glu Lys Val Phe Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Cys Asp Lys Cys Lys Ser Gly Thr Ser Arg Ser Lys Lys Lys Trp Ile 
545                 550                 555                 560 


Trp Arg Lys Ser Ser Gly Asn Glu Glu Gly Leu Gln Lys Glu Tyr Ala 
                565                 570                 575     


Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Tyr Leu Gly Asn 
            580                 585                 590         


Leu Pro Lys Leu Glu Asn Val Cys Lys Gly Val Thr Asp Ile Ile Tyr 
        595                 600                 605             


Asp Thr Lys Glu Lys Phe Leu Ser Gly Cys Leu Ile Ala Ala Phe His 
    610                 615                 620                 


Glu Gly Lys Asn Leu Lys Thr Ser His Glu Lys Lys Asn Asp Asp Asn 
625                 630                 635                 640 


Gly Lys Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly 
                645                 650                 655     


Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Asp Phe Thr Lys Asp 
            660                 665                 670         


Leu Glu Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr 
        675                 680                 685             


Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp 
705                 710                 715                 720 


Thr Ala Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Ser Gly 
                725                 730                 735     


Asp Gly Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Met Pro Thr 
            740                 745                 750         


Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu 
        755                 760                 765             


His Phe Cys Lys Gln Arg Gln Glu Lys Val Lys Asp Val Ile Thr Asn 
    770                 775                 780                 


Cys Asn Ser Cys Lys Glu Cys Gly Asp Thr Cys Asn Gly Glu Cys Lys 
785                 790                 795                 800 


Thr Glu Cys Lys Thr Lys Cys Lys Gly Glu Cys Glu Lys Tyr Lys Asn 
                805                 810                 815     


Phe Ile Glu Glu Cys Asn Gly Thr Ala Asp Gly Gly Thr Ser Gly Ser 
            820                 825                 830         


Ser Trp Ser Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys Tyr 
        835                 840                 845             


Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly 
    850                 855                 860                 


Thr Ser Ser Thr Thr Asn Ala Ala Ala Ser Thr Thr Glu Asn Lys Cys 
865                 870                 875                 880 


Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly 
                885                 890                 895     


Leu Thr Thr Pro Ser Ser Tyr Leu Ser Asn Val Leu Asp Asp Asn Ile 
            900                 905                 910         


Cys Gly Glu Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr 
        915                 920                 925             


Lys Asn Cys Asp Ile Gln Lys Lys Thr Pro Lys Pro Gln Ser Cys Asp 
    930                 935                 940                 


Thr Leu Val Val Val Asn Val Pro Ser Pro Leu Gly Asn Thr Pro His 
945                 950                 955                 960 


Gly Tyr Lys Tyr Val Cys Glu Cys Lys Ile Pro Thr Thr Glu Glu Thr 
                965                 970                 975     


Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp Ile Ile Asp Thr Ser 
            980                 985                 990         


Lys Lys Gln Lys Gly Ser Gly Ser  Thr Asn Asn Asp Tyr  Glu Leu Tyr 
        995                 1000                 1005             


Thr Tyr  Asn Gly Val Gln Ile  Lys Gln Ala Ala Gly  Thr Leu Lys 
    1010                 1015                 1020             


Asn Ser  Lys Leu Asp Glu Asn  Asp Val Met Phe Phe  Asn Leu Phe 
    1025                 1030                 1035             


Glu Gln  Trp Asn Lys Glu Ile  Gln Tyr Gln Ile Glu  Gln Tyr Met 
    1040                 1045                 1050             


Thr Asn  Thr Lys Ile Ser Cys  Asn Asn Glu Lys Asn  Val Leu Ser 
    1055                 1060                 1065             


Arg Val  Ser Glu Glu Ser Gln  Asn Gln Asn Gly Ser  Asp His His 
    1070                 1075                 1080             


Asp Gly  Gly Asn Asn Asn Thr  Asp Gln Gly Thr Asn  Cys Lys Lys 
    1085                 1090                 1095             


Asn Cys  Glu Cys Tyr Glu Leu  Trp Ile Lys Lys Ile  Thr Glu Gln 
    1100                 1105                 1110             


Trp Glu  Thr Gln Lys Lys Asn  Tyr Asn Lys Phe Gln  Ser Lys Gln 
    1115                 1120                 1125             


Ile Tyr  Asp Gly Asn Asn Ala  Ser His Lys Lys Glu  Ile Val Lys 
    1130                 1135                 1140             


Leu Ser  His Phe Leu Phe Phe  Ser Cys Trp Glu Glu  Tyr Ile Gln 
    1145                 1150                 1155             


Lys Tyr  Phe Asn Gly Asp Trp  Ser Lys Ile Lys Asn  Ile Gly Ser 
    1160                 1165                 1170             


Asp Thr  Phe Glu Phe Leu Ile  Lys Lys Cys Gly Asn  Asn Ser Gly 
    1175                 1180                 1185             


Asp Gly  Glu Thr Ile Phe Ser  Glu Lys Leu Lys Asn  Ala Gln Gln 
    1190                 1195                 1200             


Gln Cys  Lys Glu Ile Gln Asn  Thr Asp Thr Lys Ile  Asn Pro Ser 
    1205                 1210                 1215             


Val Ile  Ser Ser Val Leu Asn  Ala Thr Asn Tyr Ile  Arg Gly Cys 
    1220                 1225                 1230             


Gln Pro  Lys Arg Tyr Asp Gly  Phe Ile Ser Pro Gly  Lys Gly Gly 
    1235                 1240                 1245             


Glu Lys  Gln Trp Ile Cys Lys  Asp Thr Ile Thr His  Gly Asp Thr 
    1250                 1255                 1260             


Asn Gly  Ala Cys Ile Pro Pro  Arg Thr Gln Asn Leu  Cys Val Gly 
    1265                 1270                 1275             


Glu Leu  Trp Tyr Lys Arg Tyr  Gly Gly Arg Ser Asn  Ile Lys Asn 
    1280                 1285                 1290             


Asp Thr  Lys Glu Ser Leu Lys  Asn Lys Leu Lys Asn  Ala Ile Gln 
    1295                 1300                 1305             


Lys Glu  Thr Glu Leu Leu Tyr  Glu Tyr His Asp Thr  Gly Thr Ala 
    1310                 1315                 1320             


Ile Ile  Ser Arg Asn Pro Met  Lys Glu Gly Gly Glu  Asp Gly Lys 
    1325                 1330                 1335             


Gly Lys  Gln Lys Glu Gly Gly  Glu Glu Ala Asn Asn  Asn Ser Asn 
    1340                 1345                 1350             


Gly Leu  Pro Lys Gly Phe Cys  His Ala Val Gln Arg  Ser Phe Ile 
    1355                 1360                 1365             


Asp Tyr  Lys Asn Met Ile Leu  Gly Thr Ser Val Asn  Ile Tyr Glu 
    1370                 1375                 1380             


Tyr Ile  Gly Lys Leu Gln Glu  Asp Ile Lys Lys Ile  Ile Glu Gln 
    1385                 1390                 1395             


Glu Arg  Thr Lys Thr Lys Asp  Lys Ile Gly Gly Ser  Gly Ala Asp 
    1400                 1405                 1410             


Lys Val  Asn Asp Trp Trp Lys  Gly Ile Glu Gly Glu  Met Trp Asp 
    1415                 1420                 1425             


Ala Val  Lys Cys Ala Ile Thr  Lys Ile Lys Lys Gln  Lys Lys Asn 
    1430                 1435                 1440             


Gly Thr  Tyr Thr Gly Asn Glu  Cys Gly Val Ser Pro  Pro Thr Gly 
    1445                 1450                 1455             


Asn Asp  Glu Asp Gln Ser Val  Ser Trp Phe Lys Glu  Trp Gly Glu 
    1460                 1465                 1470             


Gln Phe  Cys Ile Glu Arg Leu  Arg Tyr Glu Gln Asn  Ile Arg Glu 
    1475                 1480                 1485             


Ala Cys  Thr Ile Asn Gly Lys  Asn Glu Lys Lys Cys  Ile Asn Ser 
    1490                 1495                 1500             


Lys Ser  Gly Gln Glu Asp Lys  Val Glu Gly Ala Cys  Lys Arg Lys 
    1505                 1510                 1515             


Cys Glu  Lys Tyr Lys Lys Tyr  Ile Ser Glu Lys Lys  Gln Glu Trp 
    1520                 1525                 1530             


Asp Lys  Gln Lys Thr Lys Tyr  Glu Asn Lys Tyr Val  Gly Lys Ser 
    1535                 1540                 1545             


Ala Ser  Asp Leu Leu Lys Glu  Asn Tyr Pro Glu Cys  Ile Ser Ala 
    1550                 1555                 1560             


Asn Phe  Asp Phe Ile Phe Asn  Asp Lys Ala Asp His  Lys Lys Tyr 
    1565                 1570                 1575             


Tyr Pro  Tyr Gly Asp Tyr Ser  Ser Ile Cys Ser Cys  Glu Gln Val 
    1580                 1585                 1590             


Lys Tyr  Tyr Lys Tyr Asn Asn  Ala Glu Lys Lys Asn  Asn Lys Ser 
    1595                 1600                 1605             


Leu Cys  His Glu Lys Gly Asn  Asp Arg Thr Trp Ser  Lys Lys Tyr 
    1610                 1615                 1620             


Ile Lys  Lys Leu Glu Asn Gly  Arg Ser Leu Glu Gly  Val Tyr Val 
    1625                 1630                 1635             


Pro Pro  Arg Arg Gln Gln Leu  Cys Leu Tyr Glu Leu  Phe Pro Ile 
    1640                 1645                 1650             


Ile Ile  Lys Asn Glu Glu Gly  Met Glu Lys Ala Lys  Glu Glu Leu 
    1655                 1660                 1665             


Leu Glu  Thr Leu Gln Ile Val  Ala Glu Arg Glu Ala  Tyr Tyr Leu 
    1670                 1675                 1680             


Trp Lys  Gln Tyr Asn Pro Thr  Gly Lys Gly Ile Asp  Asp Ala Asn 
    1685                 1690                 1695             


Lys Lys  Ala Cys Cys Ala Ile  Arg Gly Ser Phe Tyr  Asp Leu Glu 
    1700                 1705                 1710             


Asp Ile  Ile Lys Gly Asn Asp  Leu Val His Asp Glu  Tyr Thr Lys 
    1715                 1720                 1725             


Tyr Ile  Asp Ser Lys Leu Asn  Glu Ile Phe Gly Ser  Ser Asn Lys 
    1730                 1735                 1740             


Asn Asp  Ile Asp Thr Lys Arg  Ala Arg Thr Asp Trp  Trp Glu Asn 
    1745                 1750                 1755             


Glu Thr  Ile Asp Val Ala Asn  Gly Thr Asp His Lys  Thr Ile Arg 
    1760                 1765                 1770             


Gln Leu  Val Trp Asp Ala Met  Gln Ser Gly Val Arg  Lys Ala Ile 
    1775                 1780                 1785             


Asp Glu  Glu Asn Glu Lys Lys  Lys Gln Asn Lys Asn  Phe Pro Pro 
    1790                 1795                 1800             


Cys Met  Gly Val Glu His Ile  Gly Ile Ala Lys Pro  Gln Phe Ile 
    1805                 1810                 1815             


Arg Trp  Leu Glu Glu Trp Thr  Asn Glu Phe Cys Glu  Glu Tyr Thr 
    1820                 1825                 1830             


Lys Tyr  Phe Gly Ala Ile Asn  Ser Asn Cys Asn Arg  Arg Lys Gly 
    1835                 1840                 1845             


Ala Asp  Asp Cys Gly Asp Asn  Ser Asn Ile Glu Cys  Lys Arg Ala 
    1850                 1855                 1860             


Cys Ala  Asn Tyr Thr Asn Trp  Leu Asn Pro Lys Arg  Ile Glu Trp 
    1865                 1870                 1875             


Asn Gly  Met Ser Asn Tyr Tyr  Asn Lys Ile Tyr Arg  Lys Ser Asn 
    1880                 1885                 1890             


Lys Glu  Ser Glu Asp Gly Lys  Asp Tyr Ser Met Ile  Met Ala Pro 
    1895                 1900                 1905             


Thr Val  Ile Asp Tyr Leu Asn  Lys Arg Cys Asn Gly  Glu Ile Asn 
    1910                 1915                 1920             


Gly Asn  Tyr Ile Cys Cys Ser  Cys Lys Asn Ile Gly  Glu Asn Tyr 
    1925                 1930                 1935             


Asn Pro  Ser Pro Ala Gln Lys  Thr Lys Gly Ser Lys  Lys Lys Asp 
    1940                 1945                 1950             


Glu Gln  Cys Glu Asp Asn Lys  Gly Pro Leu Asp Leu  Met Asn Glu 
    1955                 1960                 1965             


Val Leu  Asn Lys Met Asp Glu  Lys Tyr Ser Ala His  
    1970                 1975                 1980 


<210>  21
<211>  1965
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21

Met Asp Ser Thr Ser Thr Ile Gly Asp Lys Ile Glu Glu Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asn Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Lys Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Glu Pro Cys Asp Ser Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Asp Glu Asn Leu Phe Lys Ala Ser Gly Asn His Lys Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Gln His Met Cys Ile Lys Asn Leu Glu Asn 
            100                 105                 110         


Leu Lys Phe Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Ile Leu Tyr His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Ile Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Lys Phe Glu Pro Tyr Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Lys 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Gln Asn Asp Asp Glu Asn Tyr Lys 
        195                 200                 205             


Lys Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Arg 
225                 230                 235                 240 


Trp Arg Thr Ser Gly Lys Ser Asn Gly Glu Asn Lys Leu Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Tyr Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Leu Tyr 
        275                 280                 285             


Arg Glu Glu Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Lys Asn Val Asp Ser Lys Glu Gly Thr Ser Tyr Cys Asn 
305                 310                 315                 320 


Met Cys Lys Glu Lys His Thr Lys Tyr Cys Glu Phe Val Asn Lys Trp 
                325                 330                 335     


Lys Ser Glu Trp Lys Asn Gln Glu Asn Lys Tyr Lys Asp Leu Tyr Gln 
            340                 345                 350         


Gln Glu Asn Lys Thr Ser Ser Ser Ser Lys Asn Thr Ser Arg Tyr Asp 
        355                 360                 365             


Asn Tyr Val Lys Glu Phe Phe Glu Lys Leu Glu Ala Asn Tyr Lys Ser 
    370                 375                 380                 


Leu Glu Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Val Thr 
385                 390                 395                 400 


Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Thr Ser Ser Gly 
                405                 410                 415     


Glu Thr Ala Asn His Asn Asp Glu Ala Cys Asn Arg Asn Glu Ser Glu 
            420                 425                 430         


Ile Ser Ser Val Glu Gln Ala Pro Ile Ser Gly Pro Ser Ser Asn Lys 
        435                 440                 445             


Thr Cys Asn Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Glu Cys 
    450                 455                 460                 


Lys Asp Val Lys Leu Gly Ile Asn Asn Asn Asp Lys Asp Leu Lys Ile 
465                 470                 475                 480 


Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys 
                485                 490                 495     


Gln Asp Phe Leu Arg Met Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asp Asn Lys Asn Gln Asp Glu Cys 
        515                 520                 525             


Gln Thr Lys Leu Asp Glu Ala Leu Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Cys Glu Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Asn Gln Trp 
545                 550                 555                 560 


Ile Trp Lys Lys Ser Arg Gly Thr Glu Gly Gly Leu Gln Glu Glu Tyr 
                565                 570                 575     


Ala Asn Thr Ile Ala Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val 
            580                 585                 590         


Cys Leu His Glu Lys Glu Glu Lys Thr Gln His Lys Thr Ile Ser Thr 
        595                 600                 605             


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
    610                 615                 620                 


Lys Asn Leu Lys Lys Arg Tyr His Gln Asn Lys Asn Ala Asp Asn Glu 
625                 630                 635                 640 


Lys Lys Lys Gly Glu Asn Lys Lys Lys Leu Cys Lys Ala Leu Lys Tyr 
                645                 650                 655     


Ser Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp 
            660                 665                 670         


Asn Glu Tyr Thr Lys Asp Leu Glu Leu Asn Leu Gln Gln Ile Phe Gly 
        675                 680                 685             


Lys Leu Phe Arg Lys Tyr Ile Lys Lys Asn Ile Ser Thr Glu Gln Asp 
    690                 695                 700                 


Thr Leu Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr 
705                 710                 715                 720 


Asn Lys Lys Tyr Ile Trp Leu Ala Met Lys His Gly Ala Glu Met Asn 
                725                 730                 735     


Gly Thr Thr Cys Cys Gly Asp Gly Ser Ser Gly Glu Asn Gln Thr Asn 
            740                 745                 750         


Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg 
        755                 760                 765             


Phe Leu Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg Gln Glu Asn 
    770                 775                 780                 


Val Asn Ala Val Ile Glu Asn Cys Lys Ser Cys Lys Glu Cys Gly Gly 
785                 790                 795                 800 


Thr Cys Gly Ser Asp Cys Lys Thr Glu Cys Glu Lys Lys Cys Lys Ala 
                805                 810                 815     


Tyr Lys Glu Phe Ile Glu Lys Cys Glu Gly Gln Ala Ala Glu Gly Thr 
            820                 825                 830         


Ser Gly Tyr Ser Trp Ser Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr 
        835                 840                 845             


Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys 
    850                 855                 860                 


Asn Cys Gly Thr Ser Ser Gly Ala Thr Ser Gly Val Thr Thr Thr Glu 
865                 870                 875                 880 


Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile 
                885                 890                 895     


Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp 
            900                 905                 910         


Asp Asn Ile Cys Gly Ala Asp Asn Ala Pro Trp Thr Thr Tyr Thr Thr 
        915                 920                 925             


Tyr Thr Thr Lys Asn Cys Asp Lys Glu Lys Asp Lys Ser Lys Ser Gln 
    930                 935                 940                 


Ser Cys Asp Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
945                 950                 955                 960 


Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro Thr Thr 
                965                 970                 975     


Glu Glu Ser Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp Ile Ile 
            980                 985                 990         


Asp Asn Thr Lys Asn Pro Lys Gly  Ser Arg Ser Thr Asn  Asn Asp Tyr 
        995                 1000                 1005             


Glu Leu  Tyr Thr Tyr Asn Gly  Val Lys Glu Thr Lys  Leu Pro Lys 
    1010                 1015                 1020             


Lys Leu  Asn Ser Ser Lys Leu  Asp Glu Asn Asp Val  Thr Phe Phe 
    1025                 1030                 1035             


Asn Leu  Phe Glu Gln Trp Asn  Lys Glu Ile Gln Tyr  Gln Ile Glu 
    1040                 1045                 1050             


Gln Tyr  Met Thr Asn Thr Lys  Ile Ser Cys Asn Asn  Glu Lys Asn 
    1055                 1060                 1065             


Val Leu  Ser Ser Ser Ser Glu  Glu Ser Lys Asn Gln  Asn Gly Ser 
    1070                 1075                 1080             


Asp His  His Asp Gly Gly Asn  Asn Asn Ile Asn Gln  Gly Thr Asn 
    1085                 1090                 1095             


Cys Lys  Glu Lys Cys Glu Cys  Tyr Glu Leu Trp Ile  Lys Lys Ile 
    1100                 1105                 1110             


Lys Glu  Gln Trp Asp Lys Gln  Lys Asn Asn Tyr Asn  Lys Phe Gln 
    1115                 1120                 1125             


Ser Lys  Gln Ile Tyr Asp Ala  Arg Lys Ser Ser Gln  Asn Lys Lys 
    1130                 1135                 1140             


Glu Ile  Val Lys Leu Ser His  Phe Leu Phe Phe Ser  Cys Trp Glu 
    1145                 1150                 1155             


Glu Tyr  Ile Gln Lys Tyr Phe  Asn Gly Asp Trp Ser  Lys Ile Lys 
    1160                 1165                 1170             


Asn Ile  Gly Ser Asp Thr Phe  Glu Phe Leu Ile Lys  Lys Cys Gly 
    1175                 1180                 1185             


Asn Asn  Ser Gly Asp Gly Glu  Thr Ile Phe Ser Glu  Lys Leu Lys 
    1190                 1195                 1200             


Asn Ala  His Ile Lys Cys Lys  Glu Asn Glu Ser Thr  Asp Thr Lys 
    1205                 1210                 1215             


Ile Asn  Lys Ser Glu Thr Ser  Ser Lys Cys Asn Lys  Thr Asn Tyr 
    1220                 1225                 1230             


Ile Arg  Gly Cys Gln Ser Lys  Arg Tyr Asp Gly Lys  Ile Phe Pro 
    1235                 1240                 1245             


Gly Lys  Gly Gly Glu Lys Gln  Trp Ile Cys Lys Asp  Thr Ile Thr 
    1250                 1255                 1260             


His Gly  Asp Thr Asn Gly Ala  Cys Ile Pro Pro Arg  Thr Gln Asn 
    1265                 1270                 1275             


Leu Cys  Val Gly Glu Leu Trp  Asp Lys Ser Tyr Gly  Gly Arg Ser 
    1280                 1285                 1290             


Asn Ile  Lys Asn Asp Thr Lys  Glu Leu Leu Lys Asn  Lys Leu Lys 
    1295                 1300                 1305             


Asn Ala  Ile Gln Lys Glu Thr  Glu Leu Leu Tyr Glu  Tyr His Asp 
    1310                 1315                 1320             


Lys Gly  Thr Ala Ile Ile Ser  Gln Asn Asp Lys Lys  Gly Gln Lys 
    1325                 1330                 1335             


Gly Lys  Asn Asp Pro Asn Gly  Leu Pro Lys Gly Phe  Cys His Ala 
    1340                 1345                 1350             


Val Gln  Arg Ser Phe Ile Asp  Tyr Lys Asn Met Ile  Leu Gly Thr 
    1355                 1360                 1365             


Ser Val  Asn Thr Tyr Glu Tyr  Ile Gly Lys Leu Gln  Glu Asp Ile 
    1370                 1375                 1380             


Lys Lys  Ile Ile Glu Lys Gly  Thr Thr Lys Gln Asn  Gly Lys Thr 
    1385                 1390                 1395             


Val Gly  Ser Gly Ala Asp Lys  Val Asn Asp Trp Trp  Lys Glu Ile 
    1400                 1405                 1410             


Glu Lys  Asp Met Trp Gly Ala  Val Lys Ser Gly Ile  Lys Thr Ile 
    1415                 1420                 1425             


Lys Lys  Gln Asn Asn Lys Cys  Thr Tyr Thr Gly Asn  Glu Cys Gly 
    1430                 1435                 1440             


Val Ser  Pro Pro Thr Gly Asn  Asp Glu Asp Gln Phe  Val Ser Trp 
    1445                 1450                 1455             


Phe Lys  Glu Trp Gly Glu Gln  Phe Cys Ile Glu Arg  Leu Gln Tyr 
    1460                 1465                 1470             


Glu Gln  Asn Ile Arg Asp Ala  Cys Thr Asn Asn Gly  Lys Asn Glu 
    1475                 1480                 1485             


Lys Lys  Cys Ile Asn Ser Lys  Asn Asn Asn Glu Lys  Glu Ile Gln 
    1490                 1495                 1500             


Gly Asp  Cys Lys Arg Lys Cys  Glu Glu Tyr Lys Lys  Tyr Ile Ser 
    1505                 1510                 1515             


Glu Lys  Lys Gln Glu Trp Asp  Lys Gln Lys Thr Lys  Tyr Glu Asn 
    1520                 1525                 1530             


Lys Tyr  Val Gly Lys Ser Ala  Ser Asp Leu Leu Lys  Glu Asn Tyr 
    1535                 1540                 1545             


Pro Glu  Cys Ile Ser Ala Asn  Phe Asp Phe Ile Phe  Asn Asp Asn 
    1550                 1555                 1560             


Ile Glu  Tyr Lys Thr Tyr Tyr  Pro Tyr Gly Asp Tyr  Ser Ser Ile 
    1565                 1570                 1575             


Cys Ser  Cys Glu Gln Val Lys  Tyr Tyr Lys Tyr Asn  Asn Ala Glu 
    1580                 1585                 1590             


Lys Lys  Asn Asn Lys Ser Leu  Cys His Glu Lys Gly  Asn Asp Arg 
    1595                 1600                 1605             


Thr Trp  Ser Lys Lys Tyr Ile  Lys Lys Leu Glu Asn  Gly Arg Thr 
    1610                 1615                 1620             


Leu Glu  Gly Val Tyr Val Pro  Pro Arg Arg Gln Gln  Leu Cys Leu 
    1625                 1630                 1635             


Tyr Glu  Leu Phe Pro Ile Ile  Ile Lys Lys Glu Lys  Asp Met Glu 
    1640                 1645                 1650             


Lys Ala  Lys Glu Leu Leu Glu  Thr Leu Gln Ile Val  Ala Glu Arg 
    1655                 1660                 1665             


Glu Ala  Tyr Tyr Leu Trp Lys  Gln Tyr Asn Pro Thr  Gly Lys Gly 
    1670                 1675                 1680             


Ile Asp  Asp Ala Asn Lys Lys  Ala His Lys Lys Ala  Cys Cys Ala 
    1685                 1690                 1695             


Ile Arg  Gly Ser Phe Tyr Asp  Leu Glu Asp Ile Ile  Lys Gly Asn 
    1700                 1705                 1710             


Asp Leu  Val His Asp Glu Tyr  Thr Lys Tyr Ile Asp  Ser Lys Leu 
    1715                 1720                 1725             


Asn Glu  Ile Phe Gly Ser Ser  Asn Thr Asn Asp Ile  Glu Thr Lys 
    1730                 1735                 1740             


Arg Ala  Arg Thr Asp Trp Trp  Glu Asn Glu Thr Ile  Gly Val Ala 
    1745                 1750                 1755             


Asn Gly  Thr Asp Ser Lys Thr  Ile Arg Gln Leu Val  Trp Asp Ala 
    1760                 1765                 1770             


Met Gln  Ser Gly Val Ile Tyr  Ala Glu Glu Lys Lys  Glu Asn Phe 
    1775                 1780                 1785             


Pro Pro  Cys Met Arg Val Glu  His Ile Gly Ile Ala  Lys Pro Gln 
    1790                 1795                 1800             


Phe Ile  Arg Trp Leu Glu Glu  Trp Thr Asn Glu Phe  Cys Glu Lys 
    1805                 1810                 1815             


Tyr Thr  Lys Tyr Phe Glu Asp  Met Lys Ser Lys Cys  Asp Pro Pro 
    1820                 1825                 1830             


Lys Gly  Ala Asp Asp Cys Asp  Asp Asn Ser Asn Ile  Glu Cys Lys 
    1835                 1840                 1845             


Arg Ala  Cys Ala Asn Tyr Thr  Asn Trp Leu Asn Pro  Lys Arg Ile 
    1850                 1855                 1860             


Glu Trp  Asn Gly Met Ser Asn  Tyr Tyr Asn Lys Ile  Tyr Arg Lys 
    1865                 1870                 1875             


Ser Asn  Lys Glu Ser Glu Asp  Gly Lys Asp Tyr Ser  Met Ile Met 
    1880                 1885                 1890             


Glu Pro  Thr Val Ile Asp Tyr  Leu Asn Lys Arg Cys  His Gly Glu 
    1895                 1900                 1905             


Ile Asn  Gly Asn Tyr Ile Cys  Cys Ser Cys Lys Asn  Ile Gly Glu 
    1910                 1915                 1920             


Asn Ser  Thr Ser Gly Thr Val  Asn Lys Lys Leu Gln  Lys Lys Glu 
    1925                 1930                 1935             


Thr Glu  Cys Glu Asp Asn Lys  Gly Pro Leu Asp Leu  Met Asn Glu 
    1940                 1945                 1950             


Val Leu  Asn Lys Met Asp Lys  Lys Tyr Ser Ala His  
    1955                 1960                 1965 


<210>  22
<211>  1963
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22

Met Asp Lys Ser Ser Ile Gly Asp Lys Ile Glu Ala Tyr Leu Glu Lys 
1               5                   10                  15      


Lys Ser Asp Glu Ser Asp Ile Glu Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Arg Lys 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr Glu 
    50                  55                  60                  


Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Ile Asp Glu Trp Lys 
65                  70                  75                  80  


Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Lys Pro Glu Asn Ile Cys 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Asn Leu 
            100                 105                 110         


Lys Phe Asp Lys Ile Arg Asp Asn Asn Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn Lys 
                165                 170                 175     


Phe Glu Pro Cys Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn Asp 
            180                 185                 190         


Lys Val Leu Gln Asp Lys Tyr Pro Asn Asp Asp Pro Lys Tyr Thr Lys 
        195                 200                 205             


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
    210                 215                 220                 


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Leu Gly Trp 
225                 230                 235                 240 


Thr Ser Ser Lys Glu Ser Glu Gly Asp Asn Lys Leu Glu Leu Cys Arg 
                245                 250                 255     


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
            260                 265                 270         


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
        275                 280                 285             


Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His Arg Glu Glu Cys 
    290                 295                 300                 


Thr Arg Lys Asn Val Glu Ser Lys Glu Gly Thr Ser Tyr Cys Thr Asn 
305                 310                 315                 320 


Cys Lys Glu Lys Cys Lys Lys Tyr Cys Glu Tyr Val Asn Lys Trp Lys 
                325                 330                 335     


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Asn Asp Leu Tyr Gln Gln 
            340                 345                 350         


Glu Asn Lys Thr Ser Ser Ser Ser Lys Lys Lys Ser Arg Tyr Asp Asp 
        355                 360                 365             


Tyr Val Lys Glu Phe Phe Lys Asn Phe Lys Gly Asp Asn Tyr Lys Ser 
    370                 375                 380                 


Leu Glu Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr 
385                 390                 395                 400 


Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Thr Glu Asn Ala Ser Glu 
                405                 410                 415     


Thr Pro Ser Lys Tyr Tyr Asp Glu Ala Cys Asn Cys Asn Glu Ser Glu 
            420                 425                 430         


Ile Ala Ser Val Gly Gln Ala Gln Thr Ser Gly Pro Ser Ser Asn Lys 
        435                 440                 445             


Thr Cys Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Glu Cys 
    450                 455                 460                 


Lys Asp Val Lys Leu Gly Ile Asn Asn Asn Asp Lys Val Leu Arg Val 
465                 470                 475                 480 


Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys 
                485                 490                 495     


Gln Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asp Lys Asn Ser Glu Glu Ile Cys 
        515                 520                 525             


Gln Lys Lys Leu Glu Lys Val Phe Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Cys Asp Lys Cys Lys Ser Gly Thr Ser Arg Ser Lys Lys Lys Trp Ile 
545                 550                 555                 560 


Trp Lys Lys Ser Ser Gly Asn Glu Glu Gly Leu Gln Lys Glu Tyr Ala 
                565                 570                 575     


Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Cys 
            580                 585                 590         


Leu His Glu Lys Glu Gly Lys Thr Gln His Lys Thr Ile Ser Thr Asn 
        595                 600                 605             


Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly Lys 
    610                 615                 620                 


Asn Leu Lys Thr Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys Lys 
625                 630                 635                 640 


Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile 
                645                 650                 655     


Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu Leu 
            660                 665                 670         


Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys Lys 
        675                 680                 685             


Asn Asn Thr Ala Glu Gln His Thr Ser Tyr Ser Ser Leu Asp Glu Leu 
    690                 695                 700                 


Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Thr Ala Met 
705                 710                 715                 720 


Lys His Gly Ala Gly Met Asn Gly Thr Thr Cys Ser Cys Ser Gly Asp 
                725                 730                 735     


Ser Ser Asn Asp Met Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg 
            740                 745                 750         


Phe Leu Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg Gln Glu Lys 
        755                 760                 765             


Val Asn Ala Val Ile Glu Asn Cys Asn Ser Cys Lys Glu Ser Gly Gly 
    770                 775                 780                 


Thr Cys Asn Ser Asp Cys Lys Thr Glu Cys Lys Asn Lys Cys Glu Ala 
785                 790                 795                 800 


Tyr Lys Glu Phe Ile Glu Asp Cys Lys Gly Gly Gly Thr Gly Thr Ala 
                805                 810                 815     


Gly Ser Pro Trp Ser Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser 
            820                 825                 830         


Lys His Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn 
        835                 840                 845             


Cys Gly Thr Ser Ser Thr Thr Asn Ala Ala Ala Ser Thr Asp Glu Asn 
    850                 855                 860                 


Lys Cys Val Gln Ser Asp Val Asp Ser Phe Phe Lys His Leu Ile Asp 
865                 870                 875                 880 


Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Asn Val Leu Asp Asp 
                885                 890                 895     


Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr 
            900                 905                 910         


Thr Thr Thr Lys Asn Cys Asp Ile Gln Lys Lys Thr Pro Lys Ser Gln 
        915                 920                 925             


Ser Cys Asp Thr Leu Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
    930                 935                 940                 


Thr Pro His Glu Tyr Lys Tyr Ala Cys Glu Cys Lys Ile Pro Thr Thr 
945                 950                 955                 960 


Glu Glu Thr Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp Ser Cys 
                965                 970                 975     


Gly Ser Ala Gln Thr Val Arg Gly Arg Ser Gly Lys Asp Asp Tyr Glu 
            980                 985                 990         


Leu Tyr Thr Tyr Asn Gly Val Lys  Glu Thr Lys Pro Leu  Gly Thr Leu 
        995                 1000                 1005             


Lys Asn  Ser Lys Leu Asp Gly  Asn Asp Val Met Phe  Phe Asn Leu 
    1010                 1015                 1020             


Phe Glu  Gln Trp Asn Lys Glu  Ile Gln Tyr Gln Ile  Glu Gln Tyr 
    1025                 1030                 1035             


Met Thr  Asn Thr Lys Ile Ser  Cys Asn Asn Glu Met  Lys Ile Leu 
    1040                 1045                 1050             


Ser Ser  Ser Ser Glu Glu Ser  Gln Asn Gln Asn Gly  Ser Asp His 
    1055                 1060                 1065             


His Asp  Gly Arg Asn Asn Asn  Ile Asn Gln Gly Thr  Asn Cys Lys 
    1070                 1075                 1080             


Lys Asn  Cys Glu Cys Tyr Ser  Leu Trp Ile Glu Lys  Ile Lys Lys 
    1085                 1090                 1095             


Gln Trp  Asp Lys Gln Lys Asp  Asn Tyr Asn Lys Phe  Gln Arg Lys 
    1100                 1105                 1110             


Gln Ile  Tyr Asp Ala Asn Lys  Gly Pro Gln Asn Lys  Lys Val Val 
    1115                 1120                 1125             


Ser Leu  Ser His Phe Leu Phe  Phe Ser Cys Trp Glu  Glu Tyr Ile 
    1130                 1135                 1140             


Gln Lys  Tyr Phe Asn Gly Asp  Trp Ser Lys Ile Lys  Asn Ile Gly 
    1145                 1150                 1155             


Ser Asp  Thr Phe Glu Phe Leu  Ile Lys Lys Cys Gly  Asn Asp Ser 
    1160                 1165                 1170             


Gly Asp  Gly Glu Thr Ile Phe  Asn Lys Lys Leu Asn  Asn Ala Asn 
    1175                 1180                 1185             


Ile Lys  Cys Asn Glu Asn Ala  Ser Lys Asp Thr Lys  Ile Asn Lys 
    1190                 1195                 1200             


Ser Glu  Thr Ser Ser Lys Cys  Ser Glu Pro Ile Tyr  Ile Arg Gly 
    1205                 1210                 1215             


Cys Gln  Ser Lys Arg Tyr Asp  Gly Phe Ile Ser Pro  Gly Lys Gly 
    1220                 1225                 1230             


Gly Glu  Lys Gln Trp Ile Cys  Lys Asp Thr Ile Ile  His Gly Asp 
    1235                 1240                 1245             


Thr Asn  Gly Ala Cys Ile Pro  Pro Arg Thr Gln Asn  Leu Cys Val 
    1250                 1255                 1260             


Gly Glu  Leu Trp Asp Lys Arg  Tyr Gly Gly Arg Ser  Asn Ile Lys 
    1265                 1270                 1275             


Asn Asp  Thr Lys Glu Ser Leu  Lys Asn Lys Leu Lys  Asn Ala Ile 
    1280                 1285                 1290             


Gln Lys  Glu Thr Glu Leu Leu  Tyr Glu Tyr His Asp  Thr Gly Thr 
    1295                 1300                 1305             


Ala Ile  Ile Ser Arg Asn Pro  Met Lys Glu Gly Gly  Glu Asp Gly 
    1310                 1315                 1320             


Lys Gly  Lys Gln Lys Glu Gly  Gly Glu Glu Ala Asn  Asn Asn Phe 
    1325                 1330                 1335             


Asn Gly  Leu Pro Lys Gly Phe  Cys His Ala Val Gln  Arg Ser Phe 
    1340                 1345                 1350             


Ile Asp  Tyr Lys Asn Met Ile  Leu Gly Thr Ser Val  Ser Thr Tyr 
    1355                 1360                 1365             


Glu Tyr  Ile Gly Lys Leu Gln  Glu Asp Ile Lys Lys  Ile Ile Glu 
    1370                 1375                 1380             


Gln Gly  Arg Lys Pro Lys Asp  Lys Thr Val Gly Ser  Gly Ala Asp 
    1385                 1390                 1395             


Lys Val  Asn Asp Trp Trp Lys  Glu Ile Glu Lys Asp  Met Trp Gly 
    1400                 1405                 1410             


Ala Val  Lys Cys Gly Ile Lys  Thr Ile Lys Lys Gln  Lys Lys Asn 
    1415                 1420                 1425             


Gly Thr  Phe Asn Gly Asp Glu  Cys Gly Val Ser Pro  Pro Thr Gly 
    1430                 1435                 1440             


Asn Asp  Glu Asp Gln Phe Val  Ser Trp Phe Lys Glu  Trp Gly Glu 
    1445                 1450                 1455             


Gln Phe  Cys Ile Glu Arg Leu  Arg Tyr Glu Gln Asn  Ile Arg Asp 
    1460                 1465                 1470             


Ala Cys  Ile Asn Lys Asp Met  Glu Gln Asn Lys Cys  Ile Asn Ser 
    1475                 1480                 1485             


Lys Asn  Asn Asn Glu Lys Glu  Ile Gln Gly Asp Cys  Lys Arg Lys 
    1490                 1495                 1500             


Cys Glu  Lys Tyr Lys Lys Tyr  Ile Ser Glu Lys Lys  Gln Glu Trp 
    1505                 1510                 1515             


Asp Lys  Gln Lys Thr Lys Tyr  Glu Asn Lys Tyr Val  Gly Lys Ser 
    1520                 1525                 1530             


Ala Ser  Asp Leu Leu Lys Glu  Asn Tyr Pro Glu Cys  Ile Ser Ala 
    1535                 1540                 1545             


Asn Phe  Asp Phe Ile Phe Asn  Asp Asn Ile Glu Tyr  Lys Thr Tyr 
    1550                 1555                 1560             


Tyr Pro  Tyr Gly Asp Tyr Ser  Ser Ile Cys Ser Cys  Glu Gln Val 
    1565                 1570                 1575             


Lys Tyr  Tyr Lys Tyr Ile Lys  Asp Lys Gly Gln Asn  Asn Lys Ser 
    1580                 1585                 1590             


Leu Cys  His Glu Lys Gly Asn  Asp Arg Thr Trp Ser  Lys Lys Tyr 
    1595                 1600                 1605             


Ile Lys  Lys Leu Glu Asn Gly  Arg Thr Leu Glu Gly  Val Tyr Val 
    1610                 1615                 1620             


Pro Pro  Arg Arg Gln Gln Leu  Cys Leu Tyr Glu Leu  Phe Pro Ile 
    1625                 1630                 1635             


Ile Ile  Lys Lys Glu Lys Asp  Met Glu Lys Ala Lys  Glu Glu Leu 
    1640                 1645                 1650             


Leu Glu  Thr Leu Gln Ile Val  Ala Glu Arg Glu Ala  Tyr Tyr Leu 
    1655                 1660                 1665             


Trp Lys  Gln Tyr His Ala His  Asn Asp Thr Thr Tyr  Leu Ala His 
    1670                 1675                 1680             


Lys Lys  Ala Cys Cys Ala Ile  Arg Gly Ser Phe Tyr  Asp Leu Glu 
    1685                 1690                 1695             


Asp Ile  Ile Lys Gly Asn Asp  Leu Val His Asp Glu  Tyr Thr Lys 
    1700                 1705                 1710             


Tyr Ile  Asp Ser Lys Leu Asn  Glu Ile Phe Gly Ser  Ser Asn Lys 
    1715                 1720                 1725             


Asn Asp  Ile Glu Thr Lys Arg  Ala Arg Thr Asp Trp  Trp Glu Asn 
    1730                 1735                 1740             


Glu Thr  Ile Asp Val Ala Asn  Gly Thr Asp Arg Lys  Thr Ile Arg 
    1745                 1750                 1755             


Gln Leu  Val Trp Asp Ala Met  Gln Ser Gly Val Arg  Lys Ala Ile 
    1760                 1765                 1770             


Asp Glu  Glu Lys Glu Lys Lys  Lys Pro Asn Lys Asn  Phe Pro Pro 
    1775                 1780                 1785             


Cys Met  Gly Val Glu His Ile  Gly Ile Ala Lys Pro  Gln Phe Ile 
    1790                 1795                 1800             


Arg Trp  Leu Glu Glu Trp Thr  Asn Glu Phe Cys Glu  Glu Tyr Thr 
    1805                 1810                 1815             


Lys Tyr  Phe Gly Ala Ile Asn  Ser Asn Cys Asn Leu  Arg Lys Gly 
    1820                 1825                 1830             


Ala Asp  Asp Cys Gly Asp Asn  Ser Asn Ile Glu Cys  Lys Arg Ala 
    1835                 1840                 1845             


Cys Ala  Asn Tyr Thr Asn Trp  Leu Asn Pro Lys Arg  Ile Glu Trp 
    1850                 1855                 1860             


Asn Gly  Met Ser Asn Tyr Tyr  Asn Lys Ile Tyr Arg  Lys Ser Asn 
    1865                 1870                 1875             


Lys Glu  Ser Glu Asp Gly Lys  Asp Tyr Ser Met Ile  Met Glu Pro 
    1880                 1885                 1890             


Thr Val  Ile Asp Tyr Leu Asn  Lys Arg Cys Asn Gly  Glu Ile Asn 
    1895                 1900                 1905             


Gly Asn  Tyr Ile Cys Cys Ser  Cys Lys Asn Ile Gly  Glu Asn Ser 
    1910                 1915                 1920             


Thr Ser  Pro Val Ala Asn Lys  Lys Ala Gln Arg Lys  Glu Thr Glu 
    1925                 1930                 1935             


Cys Glu  Glu Glu Lys Gly Pro  Leu Asp Leu Met Asn  Glu Val Leu 
    1940                 1945                 1950             


Asn Lys  Met Asp Glu Lys Tyr  Ser Ala His 
    1955                 1960             


<210>  23
<211>  1974
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23

Met Asp Lys Ser Ser Ile Gly Asp Lys Ile Glu Glu Tyr Leu Lys Glu 
1               5                   10                  15      


Lys Ser Asn Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Arg Ser Gly Gly Asp Gly Tyr Tyr Leu Lys Asn 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Asp Glu Asn Leu Tyr Lys Ala Ser Glu Asn Asn Lys Asn Ile Phe 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Lys Leu 
            100                 105                 110         


Asn Val Glu Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Leu Ala Asp Ile Ile Arg Gly Arg Asp Gly Asn Lys Cys Glu Thr Lys 
                165                 170                 175     


Ser Thr Asn Asn Val Glu Glu Leu Ile Lys Lys Phe Phe Glu Lys Asn 
            180                 185                 190         


Tyr Arg Glu Asn Lys Glu Tyr Lys Arg Lys Tyr Arg Asn Asp Asp Pro 
        195                 200                 205             


Lys Tyr Thr Lys Leu Arg Glu Asp Trp Trp Thr Lys Asn Arg Gln Lys 
    210                 215                 220                 


Val Trp Glu Val Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile 
225                 230                 235                 240 


Lys Arg Arg Trp Arg Thr Ser Gly Lys Ser Asn Gly Glu Asn Lys Leu 
                245                 250                 255     


Glu Leu Cys Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Lys 
            260                 265                 270         


Leu Asp Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu 
        275                 280                 285             


Asp Leu Tyr Arg Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His 
    290                 295                 300                 


Arg Glu Glu Cys Thr Ser Glu Asp Asp Lys Ser Lys Glu Val Thr Ser 
305                 310                 315                 320 


Tyr Cys Asn Met Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Tyr Val 
                325                 330                 335     


Asn Lys Trp Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu 
            340                 345                 350         


Leu Tyr Glu Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Ala Ser Arg 
        355                 360                 365             


Tyr Asp Asp Tyr Val Lys Asp Phe Phe Lys Lys Leu Asn Glu Ala Asn 
    370                 375                 380                 


Tyr Lys Ser Leu Asp Asp Tyr Ile Lys Asp Asp Pro Tyr Ser Lys Glu 
385                 390                 395                 400 


Tyr Val Thr Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Thr 
                405                 410                 415     


Ser Ser Gly Glu Thr Ala Asn His Asn Asp Glu Ala Cys Asn Pro Asn 
            420                 425                 430         


Glu Ser Glu Ile Ser Ser Val Gly Gln Ala Pro Ile Ser Asp Pro Ser 
        435                 440                 445             


Ser Asn Lys Thr Cys Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys 
    450                 455                 460                 


Lys Glu Cys Lys His Val Lys Leu Gly Val Arg Glu Asn Asp Lys Val 
465                 470                 475                 480 


Leu Arg Val Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn 
                485                 490                 495     


Cys Cys Cys Gln Asp Leu Leu Gly Met Leu Gln Glu Pro Arg Ile Asp 
            500                 505                 510         


Lys Asn Gln Arg Gly Ser Ser Ser Asn Gly Ser Cys Asp Lys Asn Ser 
        515                 520                 525             


Glu Glu Ile Cys Gln Lys Lys Leu Asp Glu Ala Leu Ala Ser Leu Thr 
    530                 535                 540                 


Asn Gly Tyr Lys Cys Asp Lys Cys Lys Ser Gly Thr Ser Thr Val Asn 
545                 550                 555                 560 


Lys Asn Trp Ile Trp Lys Lys Tyr Ser Gly Lys Glu Gly Gly Leu Gln 
                565                 570                 575     


Glu Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu 
            580                 585                 590         


Cys Leu Val Cys Leu His Glu Lys Glu Gly Lys Thr Gln His Lys Thr 
        595                 600                 605             


Ile Ser Thr Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Asp Ala Phe 
    610                 615                 620                 


His Glu Gly Lys Asn Leu Lys Thr Ser His Gln Asn Lys Asn Ser Gly 
625                 630                 635                 640 


Asn Lys Glu Asn Leu Cys Lys Asp Leu Lys Tyr Ser Phe Ala Asp Tyr 
                645                 650                 655     


Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys 
            660                 665                 670         


Asp Leu Glu Leu Asn Leu Gln Lys Ala Phe Gly Lys Leu Phe Arg Lys 
        675                 680                 685             


Tyr Ile Lys Lys Asn Asn Thr Ala Glu Gln His Thr Ser Tyr Ser Ser 
    690                 695                 700                 


Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile 
705                 710                 715                 720 


Trp Leu Ala Met Lys His Gly Ala Gly Met Asn Gly Thr Thr Cys Cys 
                725                 730                 735     


Gly Asp Gly Ser Val Thr Gly Ser Ser Asp Ser Gly Ser Thr Thr Cys 
            740                 745                 750         


Ser Gly Asp Asn Gly Ser Ile Ser Cys Asp Asp Ile Pro Thr Ile Asp 
        755                 760                 765             


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
    770                 775                 780                 


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Thr Asn Cys Asn 
785                 790                 795                 800 


Ser Cys Lys Asn Thr Ser Ser Lys Thr Lys Leu Gly Gly Thr Cys Asn 
                805                 810                 815     


Ser Asp Cys Glu Lys Lys Cys Lys Asp Glu Cys Glu Lys Tyr Lys Lys 
            820                 825                 830         


Phe Ile Glu Glu Phe Cys Thr Ala Ala Gly Gly Thr Ser Gly Ser Pro 
        835                 840                 845             


Trp Ser Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile 
    850                 855                 860                 


Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly Pro 
865                 870                 875                 880 


Ser Ser Thr Thr Ser Thr Ala Glu Asn Lys Cys Val Gln Ser Asp Ile 
                885                 890                 895     


Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser 
            900                 905                 910         


Ser Tyr Leu Ser Ile Val Leu Asp Glu Asn Asn Cys Gly Glu Asp Asn 
        915                 920                 925             


Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Lys Asn Cys Asp 
    930                 935                 940                 


Ile Gln Lys Lys Thr Pro Lys Ser Gln Ser Cys Asn Thr Ala Val Val 
945                 950                 955                 960 


Val Asn Val Pro Ser Pro Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr 
                965                 970                 975     


Ala Cys Gln Cys Lys Ile Pro Thr Thr Glu Glu Ser Cys Asp Asp Arg 
            980                 985                 990         


Lys Glu Tyr Met Asn Gln Trp Ser  Ser Gly Ser Ala Gln  Thr Val Arg 
        995                 1000                 1005             


Gly Arg  Ser Thr Asn Asn Asp  Tyr Glu Leu Tyr Thr  Tyr Asn Gly 
    1010                 1015                 1020             


Val Lys  Glu Thr Lys Leu Pro  Lys Lys Leu Asn Ser  Ser Lys Leu 
    1025                 1030                 1035             


Asp Gly  Asn Asp Val Met Phe  Phe Asn Leu Phe Glu  Gln Trp Asn 
    1040                 1045                 1050             


Lys Glu  Ile Gln Tyr Gln Ile  Glu Gln Tyr Met Thr  Asn Ala Asn 
    1055                 1060                 1065             


Ile Ser  Cys Asn Asn Glu Met  Asn Val Leu Ser Ser  Ser Ser Glu 
    1070                 1075                 1080             


Glu Ser  Lys Asn Gln Asn Gly  Ser Asp His Pro Asp  Gly Arg Asn 
    1085                 1090                 1095             


Asn Asn  Ile Asn Gln Gly Thr  Asn Cys Lys Glu Lys  Cys Lys Cys 
    1100                 1105                 1110             


Tyr Glu  Leu Trp Ile Lys Lys  Ile Lys Glu Gln Trp  Gly Lys Gln 
    1115                 1120                 1125             


Lys Asp  Asn Tyr Asn Lys Phe  Glu Lys Lys Thr Ser  Asn Asp Ala 
    1130                 1135                 1140             


Arg Lys  Ser Ser Gln Asn Lys  Lys Val Val Ser Leu  Ser His Phe 
    1145                 1150                 1155             


Leu Phe  Phe Ser Cys Trp Glu  Glu Tyr Ile Gln Lys  Tyr Phe Asn 
    1160                 1165                 1170             


Gly Asp  Trp Ser Lys Ile Lys  Asn Ile Gly Ser Asp  Thr Phe Asp 
    1175                 1180                 1185             


Phe Leu  Ile Lys Lys Cys Gly  Asn Asp Ser Ala His  Gly Glu Thr 
    1190                 1195                 1200             


Ile Phe  Asn Lys Lys Leu Asn  Asn Ala Asn Ile Lys  Cys Asn Glu 
    1205                 1210                 1215             


Asn Glu  Ser Thr Asn Asn Lys  Met Lys Ser Ser Glu  Thr Ser Cys 
    1220                 1225                 1230             


Asp Cys  Ser Glu Pro Ile Tyr  Ile Arg Gly Cys Gln  Ser Lys Thr 
    1235                 1240                 1245             


Tyr Asp  Gly Lys Ile Phe Pro  Gly Lys Gly Gly Glu  Lys Gln Trp 
    1250                 1255                 1260             


Ile Cys  Lys Asp Thr Ile Thr  His Gly Asp Thr Asn  Gly Ala Cys 
    1265                 1270                 1275             


Ile Pro  Pro Arg Thr Gln Asn  Leu Cys Val Gly Glu  Leu Trp Asp 
    1280                 1285                 1290             


Lys Arg  Tyr Gly Gly Arg Ser  Asn Ile Lys Asn Asp  Thr Lys Glu 
    1295                 1300                 1305             


Ser Leu  Lys Asn Lys Leu Lys  Asn Ala Ile Gln Lys  Glu Thr Glu 
    1310                 1315                 1320             


Leu Leu  Tyr Glu Tyr His Asp  Lys Gly Thr Ala Ile  Ile Ser Gln 
    1325                 1330                 1335             


Asn Asp  Lys Lys Glu Lys Ala  Asn Asn Asn Asn Ser  Asn Gly Leu 
    1340                 1345                 1350             


Pro Lys  Gly Phe Cys His Ala  Val Gln Arg Ser Phe  Ile Asp Tyr 
    1355                 1360                 1365             


Lys Asn  Met Ile Leu Gly Thr  Ser Val Asn Ile Tyr  Glu His Ile 
    1370                 1375                 1380             


Gly Lys  Leu Gln Glu Asp Ile  Lys Lys Ile Ile Glu  Gln Glu Thr 
    1385                 1390                 1395             


Thr Lys  Gln Asn Gly Lys Thr  Val Gly Gly Ala Asp  Lys Val Asn 
    1400                 1405                 1410             


Ala Trp  Trp Lys Gly Ile Glu  Gly Glu Met Trp Gly  Ala Val Arg 
    1415                 1420                 1425             


Cys Ala  Ile Thr Lys Ile Asn  Lys Lys Lys Lys Asn  Gly Thr Phe 
    1430                 1435                 1440             


Ser Ile  Asp Glu Cys Gly Ile  Phe Pro Pro Thr Gly  Asn Asp Glu 
    1445                 1450                 1455             


Asp Gln  Ser Val Ser Trp Phe  Lys Glu Trp Gly Glu  Gln Phe Cys 
    1460                 1465                 1470             


Ile Glu  Arg Leu Gln Tyr Glu  Gln Asn Ile Arg Glu  Ala Cys Thr 
    1475                 1480                 1485             


Ile Asn  Gly Lys Asn Gly Lys  Lys Cys Ile Asn Ser  Lys Ser Gly 
    1490                 1495                 1500             


Gln Glu  Asp Lys Ile Gln Gly  Ala Cys Lys Arg Lys  Cys Glu Lys 
    1505                 1510                 1515             


Tyr Lys  Lys Tyr Ile Ser Glu  Lys Lys Gln Glu Trp  Asp Lys Gln 
    1520                 1525                 1530             


Lys Thr  Lys Tyr Glu Asn Lys  Tyr Val Gly Lys Ser  Ala Ser Asp 
    1535                 1540                 1545             


Leu Leu  Lys Glu Asn Tyr Pro  Glu Cys Ile Ser Ala  Asn Phe Asp 
    1550                 1555                 1560             


Phe Ile  Phe Asn Asp Asn Ile  Glu Tyr Lys Thr Tyr  Tyr Pro Tyr 
    1565                 1570                 1575             


Gly Asp  Tyr Ser Ser Ile Cys  Ser Cys Glu Gln Val  Lys Tyr Tyr 
    1580                 1585                 1590             


Glu Tyr  Asn Asn Ala Glu Lys  Lys Asn Asn Lys Ser  Leu Cys His 
    1595                 1600                 1605             


Glu Lys  Gly Asn Asp Arg Thr  Trp Ser Lys Lys Tyr  Ile Lys Lys 
    1610                 1615                 1620             


Leu Glu  Asn Gly Arg Thr Leu  Glu Gly Val Tyr Val  Pro Pro Arg 
    1625                 1630                 1635             


Arg Gln  Gln Leu Cys Leu Tyr  Glu Leu Phe Pro Ile  Ile Ile Lys 
    1640                 1645                 1650             


Asn Glu  Glu Gly Met Glu Lys  Ala Lys Glu Glu Leu  Leu Glu Thr 
    1655                 1660                 1665             


Leu Gln  Ile Ala Ala Glu Arg  Glu Ala Tyr Tyr Leu  Trp Lys Gln 
    1670                 1675                 1680             


Tyr His  Ala His Asn Asp Thr  Thr Tyr Leu Ala His  Lys Lys Ala 
    1685                 1690                 1695             


Cys Cys  Ala Ile Arg Gly Ser  Phe Tyr Asp Leu Glu  Asp Ile Ile 
    1700                 1705                 1710             


Lys Gly  Asn Asp Leu Val His  Asp Glu Tyr Thr Lys  Tyr Ile Asp 
    1715                 1720                 1725             


Ser Lys  Leu Asn Lys Ile Phe  Gly Ser Ser Asn Lys  Asn Asp Ile 
    1730                 1735                 1740             


Glu Thr  Lys Arg Ala Arg Thr  Asp Trp Trp Glu Asn  Glu Ala Ile 
    1745                 1750                 1755             


Gly Val  Ala Asn Gly Thr Asp  His Lys Thr Ile Arg  Gln Leu Val 
    1760                 1765                 1770             


Trp Asp  Ala Met Gln Ser Gly  Val Arg Tyr Ala Val  Glu Glu Lys 
    1775                 1780                 1785             


Lys Lys  Lys Lys Gln Asn Glu  Asn Phe Pro Pro Cys  Met Gly Val 
    1790                 1795                 1800             


Glu His  Ile Gly Ile Ala Lys  Pro Gln Phe Ile Arg  Trp Leu Glu 
    1805                 1810                 1815             


Glu Trp  Thr Asn Glu Phe Cys  Glu Glu Tyr Thr Lys  Tyr Phe Gly 
    1820                 1825                 1830             


Ala Ile  Asn Ser Lys Cys Asn  Leu Arg Lys Gly Ala  Asp Asp Cys 
    1835                 1840                 1845             


Asp Asp  Asn Ser Asn Ile Glu  Cys Lys Arg Ala Cys  Ala Asn Tyr 
    1850                 1855                 1860             


Thr Asn  Trp Leu Asn Pro Lys  Arg Ile Glu Trp Asn  Gly Met Ser 
    1865                 1870                 1875             


Asn Tyr  Tyr Asn Lys Ile Tyr  Arg Lys Ser Asn Lys  Glu Ser Glu 
    1880                 1885                 1890             


Asp Gly  Lys Asp Tyr Ser Met  Ile Met Glu Pro Thr  Val Ile Asp 
    1895                 1900                 1905             


Tyr Leu  Asn Lys Arg Cys His  Gly Glu Ile Asn Gly  Asn Tyr Ile 
    1910                 1915                 1920             


Cys Cys  Ser Cys Lys Asn Ile  Gly Glu Asn Ser Thr  Ser Pro Val 
    1925                 1930                 1935             


Ala Asn  Lys Lys Ala Gln Arg  Lys Asp Glu Gln Cys  Glu Asp Asn 
    1940                 1945                 1950             


Lys Gly  Pro Leu Asp Leu Met  Asn Glu Val Leu Asn  Lys Met Asp 
    1955                 1960                 1965             


Glu Lys  Tyr Ser Glu His 
    1970                 


<210>  24
<211>  1968
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24

Met Asp Ser Lys Thr Thr Ile Gly Asp Lys Ile Glu Ala Tyr Leu Glu 
1               5                   10                  15      


Lys Lys Ser Asn Glu Ser Asp Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Arg 
        35                  40                  45              


Lys Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Glu Pro Cys Asp Ser Ile Pro Pro Pro Tyr Gly Asp Ile Asp Glu Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Lys Pro Glu Asn Val 
                85                  90                  95      


Phe Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Asn 
            100                 105                 110         


Leu Asn Val Glu Arg Ile Arg Asp Asn Asn Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Ile Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Lys Asn Ile Leu Glu 
            180                 185                 190         


Lys Gly Ser Thr Ile Gln Ser Asn Tyr Ser Lys Lys Asp Gln Asn Tyr 
        195                 200                 205             


Thr Lys Leu Arg Glu Asp Trp Trp Thr Lys Asn Arg Gln Lys Val Trp 
    210                 215                 220                 


Glu Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg 
225                 230                 235                 240 


Arg Trp Thr Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys Leu Glu Leu 
                245                 250                 255     


Cys Arg Lys Cys Gly His Tyr Glu Gly Lys Val Pro Thr Lys Leu Asp 
            260                 265                 270         


Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe 
        275                 280                 285             


Tyr Arg Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His Arg Glu 
    290                 295                 300                 


Glu Cys Thr Arg Glu Asp His Lys Ser Lys Glu Gly Ala Ser Tyr Cys 
305                 310                 315                 320 


Ser Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys 
                325                 330                 335     


Trp Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Lys Asp Leu Tyr 
            340                 345                 350         


Gln Gln Glu Asn Glu Thr Ser Ser Ser Ser Lys Lys Lys Ser Arg Tyr 
        355                 360                 365             


Asp Asp Tyr Val Lys Glu Phe Phe Lys Asn Phe Lys Gly Asp Asn Tyr 
    370                 375                 380                 


Lys Ser Leu Asp Asp Tyr Ile Lys Gly Asp Pro Tyr Ser Lys Glu Tyr 
385                 390                 395                 400 


Thr Thr Lys Leu Ser Phe Ile Leu Asn Pro Ser Asp Ala Asn Thr Ser 
                405                 410                 415     


Ser Glu Lys Ile Gln Lys Asn Asn Asp Glu Ala Cys Asn Cys Asn Glu 
            420                 425                 430         


Ser Glu Ile Ala Ser Val Glu Gln Ala Ser Ile Ser Asp Arg Ser Ser 
        435                 440                 445             


Gln Lys Ala Tyr Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys 
    450                 455                 460                 


Val Cys Lys His Val Lys Leu Gly Val Arg Glu Asn Asp Lys Val Leu 
465                 470                 475                 480 


Arg Val Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Glu Asn Cys 
                485                 490                 495     


Cys Phe Lys Asp Phe Leu Arg Ile Val Glu Glu Pro Arg Ile Asp Lys 
            500                 505                 510         


Asn Gln Arg Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Asn Asn Glu 
        515                 520                 525             


Glu Ala Cys Glu Lys Asn Leu Asp Glu Ala Leu Ala Ser Leu Thr Asn 
    530                 535                 540                 


Cys Tyr Lys Cys Asp Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn 
545                 550                 555                 560 


Asn Lys Trp Ile Trp Arg Lys Phe Pro Gly Asn Gly Glu Gly Leu Gln 
                565                 570                 575     


Lys Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu 
            580                 585                 590         


Cys Leu Val Cys Leu His Glu Lys Glu Gly Lys Thr Gln Glu Leu Lys 
        595                 600                 605             


Asn Ile Arg Thr Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Asp Ala 
    610                 615                 620                 


Phe His Glu Gly Lys Asn Leu Lys Thr Ser His Gln Lys Lys Asn Ala 
625                 630                 635                 640 


Glu Asn Lys Lys Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp 
                645                 650                 655     


Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr 
            660                 665                 670         


Lys Asp Leu Glu Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg 
        675                 680                 685             


Lys Tyr Ile Lys Lys Asn Ile Ser Thr Glu Gln His Thr Ser Tyr Ser 
    690                 695                 700                 


Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr 
705                 710                 715                 720 


Ile Trp Thr Ala Met Lys His Gly Ala Glu Met Asn Ser Thr Met Cys 
                725                 730                 735     


Asn Val Asp Gly Ser Val Thr Gly Ser Ser Asp Ser Gly Ser Thr Thr 
            740                 745                 750         


Cys Ser Gly Asp Asn Gly Ser Ile Ser Cys Asp Asp Ile Pro Thr Ile 
        755                 760                 765             


Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His 
    770                 775                 780                 


Phe Cys Lys Gln Arg Gln Ala Lys Val Asn Ala Val Ile Lys Asn Cys 
785                 790                 795                 800 


Asn Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Asp Cys Lys Thr 
                805                 810                 815     


Lys Cys Lys Val Ala Cys Asp Ala Tyr Lys Lys Phe Ile Glu Glu Cys 
            820                 825                 830         


Arg Thr Ala Ala Glu Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp 
        835                 840                 845             


Tyr Gln Ile Tyr Met Arg Tyr Ser Lys His Ile Glu Asp Ala Lys Arg 
    850                 855                 860                 


Asn Arg Lys Ala Gly Thr Lys Ser Cys Gly Thr Ser Thr Ala Glu Ser 
865                 870                 875                 880 


Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp 
                885                 890                 895     


Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Asn Val Leu Asp Glu 
            900                 905                 910         


Asn Asn Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr 
        915                 920                 925             


Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Lys Asn Cys Asp Ile Gln Lys 
    930                 935                 940                 


Asp Lys Ser Lys Ser Gln Ser Cys Asn Thr Ala Val Val Val Asn Val 
945                 950                 955                 960 


Pro Ser Pro Leu Gly Asn Thr Pro Tyr Glu Tyr Lys Tyr Ala Cys Glu 
                965                 970                 975     


Cys Lys Ile Pro Thr Thr Glu Glu Thr Cys Asp Asp Arg Lys Glu Tyr 
            980                 985                 990         


Met Asn Gln Trp Ile Ser Asp Asn  Thr Lys Asn Pro Lys  Gly Ser Gly 
        995                 1000                 1005             


Ser Thr  Asn Asn Asp Tyr Glu  Leu Tyr Thr Tyr Asn  Gly Val Gln 
    1010                 1015                 1020             


Ile Lys  Gln Ala Ala Gly Arg  Ser Ser Ser Thr Lys  Leu Asp Asp 
    1025                 1030                 1035             


Lys Asp  Val Met Phe Phe Asn  Leu Phe Glu Gln Trp  Asn Lys Glu 
    1040                 1045                 1050             


Ile Gln  Tyr Gln Ile Glu Gln  Tyr Met Thr Asn Thr  Lys Ile Ser 
    1055                 1060                 1065             


Cys Ile  Asp Glu Lys Glu Val  Leu Asp Ser Val Ser  Asp Glu Gly 
    1070                 1075                 1080             


Thr Pro  Lys Val Arg Gly Gly  Tyr Glu Asp Gly Arg  Asn Asn Asn 
    1085                 1090                 1095             


Thr Asp  Gln Gly Thr Asn Cys  Lys Glu Lys Cys Glu  Cys Tyr Lys 
    1100                 1105                 1110             


Leu Trp  Met Glu Lys Ile Lys  Lys Gln Trp Glu Thr  Gln Asn Gln 
    1115                 1120                 1125             


Asn Tyr  Asn Lys Phe Glu Lys  Lys Thr Ser Ser Tyr  Ala Asn Lys 
    1130                 1135                 1140             


Gly Pro  Gln Asn Lys Lys Val  Val Ser Leu Ser His  Phe Leu Phe 
    1145                 1150                 1155             


Phe Ser  Cys Trp Glu Glu Tyr  Ile Gln Lys Tyr Phe  Asn Gly Asp 
    1160                 1165                 1170             


Trp Ser  Lys Ile Lys Asn Ile  Gly Ser Asp Thr Phe  Glu Tyr Leu 
    1175                 1180                 1185             


Ile Lys  Lys Cys Gly Asn Asp  Ser Gly Asp Gly Glu  Thr Ile Phe 
    1190                 1195                 1200             


Asn Lys  Lys Leu Lys Asn Ala  His Ile Lys Cys Asn  Glu Asn Ala 
    1205                 1210                 1215             


Ser Lys  Asn Thr Lys Ile Asn  Lys Ser Glu Thr Ser  Ser Asp Cys 
    1220                 1225                 1230             


Ser Glu  Pro Ile Tyr Ile Arg  Gly Cys Gln Ser Lys  Thr Tyr Asp 
    1235                 1240                 1245             


Gly Phe  Ile Ser Pro Gly Lys  Gly Gly Glu Lys Lys  Trp Ile Cys 
    1250                 1255                 1260             


Lys Asp  Thr Ile Thr His Gly  Asp Thr Asn Gly Ala  Cys Ile Pro 
    1265                 1270                 1275             


Pro Arg  Thr Gln Asn Leu Cys  Val Gly Glu Leu Trp  Asp Lys Ser 
    1280                 1285                 1290             


Tyr Gly  Gly Arg Ser Asn Ile  Lys Asn Asp Thr Lys  Glu Ser Leu 
    1295                 1300                 1305             


Lys Asn  Lys Leu Lys Asn Ala  Ile Gln Lys Glu Thr  Glu Leu Leu 
    1310                 1315                 1320             


Tyr Glu  Tyr His Asp Lys Gly  Thr Ala Ile Ile Ser  Gln Asn Asp 
    1325                 1330                 1335             


Lys Lys  Glu Lys Ala Asn Asn  Asn Asn Ser Asn Gly  Leu Pro Lys 
    1340                 1345                 1350             


Gly Phe  Cys His Ala Val Gln  Arg Ser Phe Ile Asp  Tyr Lys Asn 
    1355                 1360                 1365             


Met Ile  Leu Gly Thr Ser Val  Asn Ile Tyr Glu His  Ile Gly Lys 
    1370                 1375                 1380             


Leu Gln  Glu Asp Ile Lys Lys  Ile Ile Glu Gln Glu  Arg Thr Lys 
    1385                 1390                 1395             


Thr Lys  Glu Lys Thr Val Gly  Ser Gly Ala Asp Lys  Val Asn Asp 
    1400                 1405                 1410             


Trp Trp  Lys Glu Ile Glu Gly  Glu Met Trp Asp Ala  Val Arg Cys 
    1415                 1420                 1425             


Gly Ile  Thr Lys Ile Asn Lys  Lys Asn Asn Asn Ser  Ile Phe Asn 
    1430                 1435                 1440             


Gly Asn  Glu Cys Gly Asn Ser  Pro Ser Thr Gly Asn  Asp Glu Asp 
    1445                 1450                 1455             


Gln Ser  Val Ser Trp Phe Lys  Glu Trp Gly Glu Gln  Phe Cys Ile 
    1460                 1465                 1470             


Glu Arg  Leu Gln Tyr Glu Lys  Asn Ile Arg Glu Ala  Cys Thr Ile 
    1475                 1480                 1485             


Asn Gly  Lys Asn Glu Lys Lys  Cys Ile Asn Ser Lys  Ser Gly Gln 
    1490                 1495                 1500             


Gly Asp  Lys Ile Gln Gly Ala  Cys Lys Arg Lys Cys  Glu Lys Tyr 
    1505                 1510                 1515             


Lys Lys  Tyr Ile Ser Glu Lys  Lys Gln Glu Trp Asp  Lys Gln Lys 
    1520                 1525                 1530             


Thr Lys  Tyr Glu Asn Lys Tyr  Val Gly Lys Ser Ala  Ser Asp Leu 
    1535                 1540                 1545             


Leu Lys  Glu Asn Tyr Pro Glu  Cys Ile Ser Ala Asn  Phe Asp Phe 
    1550                 1555                 1560             


Ile Phe  Asn Asp Lys Ala Asp  His Lys Lys Tyr Tyr  Pro Tyr Gly 
    1565                 1570                 1575             


Asp Tyr  Asn Ser Ile Cys Ser  Cys Glu Gln Val Lys  Tyr Tyr Glu 
    1580                 1585                 1590             


Tyr Asn  Lys Asp Lys Gly Gln  Ser Asn Lys Ser Leu  Cys His Glu 
    1595                 1600                 1605             


Lys Gly  Asn Asp Arg Thr Trp  Ser Lys Lys Tyr Ile  Lys Lys Leu 
    1610                 1615                 1620             


Glu Asn  Gly Arg Thr Leu Glu  Gly Val Tyr Val Pro  Pro Arg Arg 
    1625                 1630                 1635             


Gln Gln  Leu Cys Leu Tyr Glu  Leu Phe Pro Ile Ile  Ile Lys Lys 
    1640                 1645                 1650             


Glu Lys  Asp Met Glu Asn Val  Lys Lys Glu Leu Leu  Glu Thr Leu 
    1655                 1660                 1665             


Gln Ile  Val Ala Glu Arg Glu  Ala Tyr Tyr Leu Trp  Lys Gln Tyr 
    1670                 1675                 1680             


Asn Pro  Thr Gly Lys Gly Ile  Asp Asp Ala Asn Lys  Lys Ala Cys 
    1685                 1690                 1695             


Cys Ala  Ile Arg Gly Ser Phe  Tyr Asp Leu Glu Asp  Ile Ile Lys 
    1700                 1705                 1710             


Gly Asn  Asp Leu Val His Asp  Glu Tyr Thr Lys Tyr  Ile Asp Ser 
    1715                 1720                 1725             


Lys Leu  Asn Glu Ile Phe Gly  Ser Ser Asn Lys Asn  Asp Ile Glu 
    1730                 1735                 1740             


Thr Lys  Arg Ala Arg Thr Asp  Trp Trp Glu Asn Glu  Thr Ile Thr 
    1745                 1750                 1755             


Asn Arg  Thr Asp Arg Lys Thr  Ile Arg Gln Leu Val  Trp Asp Ala 
    1760                 1765                 1770             


Met Gln  Ser Gly Val Arg Tyr  Ala Val Glu Glu Lys  Asn Glu Asn 
    1775                 1780                 1785             


Phe Pro  Pro Cys Met Gly Val  Glu His Ile Gly Ile  Ala Lys Pro 
    1790                 1795                 1800             


Gln Phe  Ile Arg Trp Leu Glu  Glu Trp Thr Asn Glu  Phe Cys Glu 
    1805                 1810                 1815             


Glu Tyr  Thr Lys Tyr Phe Glu  Asp Met Lys Ser Lys  Cys Asp Leu 
    1820                 1825                 1830             


Arg Lys  Gly Ala Asp Asp Cys  Gly Asp Asn Thr Asn  Ile Glu Cys 
    1835                 1840                 1845             


Lys Arg  Ala Cys Ala Asn Tyr  Thr Asn Trp Leu Asn  Pro Lys Arg 
    1850                 1855                 1860             


Ile Glu  Trp Asn Gly Met Ser  Asn Tyr Tyr Asn Lys  Ile Tyr Arg 
    1865                 1870                 1875             


Lys Ser  Asn Lys Glu Ser Glu  Asp Gly Lys Asp Tyr  Ser Met Ile 
    1880                 1885                 1890             


Met Glu  Pro Thr Val Ile Asp  Tyr Leu Asn Lys Arg  Cys Asn Gly 
    1895                 1900                 1905             


Glu Ile  Asn Gly Asn Tyr Ile  Cys Cys Ser Cys Lys  Asn Ile Gly 
    1910                 1915                 1920             


Glu Asn  Tyr Asn Pro Ser Pro  Ala Gln Lys Thr Lys  Gly Ser Lys 
    1925                 1930                 1935             


Lys Lys  Asp Glu Gln Cys Glu  Asp Asn Lys Gly Pro  Leu Asp Leu 
    1940                 1945                 1950             


Met Asn  Glu Val Leu Asn Lys  Met Asp Pro Lys Tyr  Ser Lys Leu 
    1955                 1960                 1965             


<210>  25
<211>  1991
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25

Met Asp Ser Thr Ser Thr Ile Ala Asn Lys Ile Glu Glu Tyr Leu Lys 
1               5                   10                  15      


Glu Lys Ser Asn Glu Ser Asp Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Arg 
        35                  40                  45              


Lys Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Asp Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Asp Glu Asn Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Asn 
            100                 105                 110         


Leu Asn Val Glu Arg Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Ile Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Lys Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu 
            180                 185                 190         


Asn Asp Lys Val Leu Gln Asp Lys Tyr Pro Asn Asp Asp Pro Lys Tyr 
        195                 200                 205             


Thr Lys Leu Arg Glu Gly Trp Trp Asn Ala Asn Arg Gln Lys Val Trp 
    210                 215                 220                 


Glu Val Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg 
225                 230                 235                 240 


Arg Trp Thr Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys Leu Glu Leu 
                245                 250                 255     


Cys Arg Lys Cys Gly His Tyr Glu Gly Lys Val Pro Thr Tyr Leu Asp 
            260                 265                 270         


Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe 
        275                 280                 285             


Tyr Arg Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His Arg Glu 
    290                 295                 300                 


Glu Cys Thr Arg Glu Asp Asp Lys Cys Lys Glu Gly Ala Ser Tyr Cys 
305                 310                 315                 320 


Ser Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys 
                325                 330                 335     


Trp Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr 
            340                 345                 350         


Glu Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp 
        355                 360                 365             


Asn Tyr Val Lys Asp Phe Phe Glu Lys Leu Glu Ala Asn Tyr Lys Ser 
    370                 375                 380                 


Leu Asp Asp Tyr Ile Lys Asp Asp Pro Tyr Phe Ala Glu Tyr Ala Thr 
385                 390                 395                 400 


Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Gly 
                405                 410                 415     


Glu Thr Ala Asn His Asn Asp Glu Val Cys Asn Pro Asn Glu Ser Glu 
            420                 425                 430         


Ile Ser Ser Val Gly Gln Ala Gln Thr Ser Gly Pro Ser Ser Asn Lys 
        435                 440                 445             


Thr Cys Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Val Cys 
    450                 455                 460                 


Lys Tyr Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Lys Ile 
465                 470                 475                 480 


Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys 
                485                 490                 495     


Gln Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Asn Asn Glu Glu Ala Cys 
        515                 520                 525             


Glu Lys Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Asn Gln Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Asn Lys Trp 
545                 550                 555                 560 


Ile Trp Lys Lys Ser Ser Gly Asn Gly Glu Gly Leu Gln Lys Glu Tyr 
                565                 570                 575     


Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Tyr Leu Gly 
            580                 585                 590         


Asn Leu Arg Lys Leu Gly Asn Val Cys Glu Asp Val Lys Asp Ile Asn 
        595                 600                 605             


Phe Asp Thr Lys Glu Lys Phe Leu Ala Gly Cys Leu Ile Ala Ala Phe 
    610                 615                 620                 


His Glu Gly Lys Asn Leu Lys Thr Thr Tyr Leu Glu Lys Lys Lys Gly 
625                 630                 635                 640 


Asp Asn Gly Lys Lys Leu Cys Lys Asp Leu Lys Tyr Ser Phe Ala Asp 
                645                 650                 655     


Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Asp Phe Thr 
            660                 665                 670         


Lys Asn Val Glu Leu Asn Leu Gln Gln Ile Phe Gly Lys Leu Phe Arg 
        675                 680                 685             


Lys Tyr Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser 
    690                 695                 700                 


Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr 
705                 710                 715                 720 


Ile Trp Leu Ala Met Lys His Gly Ala Gly Met Asn Gly Thr Thr Cys 
                725                 730                 735     


Ser Ser Gly Ser Gly Asp Asn Gly Asp Ser Ser Ile Thr Gly Ser Ser 
            740                 745                 750         


Asp Ser Gly Ser Thr Thr Cys Ser Gly Asp Asn Gly Ser Ile Ser Cys 
        755                 760                 765             


Asp Asp Ile Pro Thr Ile Asp Phe Ile Pro Gln Tyr Leu Arg Phe Leu 
    770                 775                 780                 


Gln Glu Trp Val Glu Asn Phe Cys Glu Gln Arg Gln Ala Lys Val Asn 
785                 790                 795                 800 


Ala Val Ile Asn Ser Cys Asn Ser Cys Lys Asn Thr Ser Gly Glu Arg 
                805                 810                 815     


Lys Ile Gly Asp Thr Cys Asn Ser Asp Cys Lys Thr Glu Cys Lys Asn 
            820                 825                 830         


Lys Cys Glu Ala Tyr Lys Thr Phe Ile Asp Asn Val Gly Asp Gly Thr 
        835                 840                 845             


Ala Gly Ser Pro Trp Val Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr 
    850                 855                 860                 


Ser Lys His Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys 
865                 870                 875                 880 


Asn Cys Gly Ile Thr Thr Gly Thr Ile Ser Gly Glu Ser Ser Gly Ala 
                885                 890                 895     


Thr Ser Gly Val Thr Thr Thr Glu Asn Lys Cys Val Gln Ser Asp Ile 
            900                 905                 910         


Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser 
        915                 920                 925             


Ser Tyr Leu Ser Ile Val Leu Asp Glu Asn Asn Cys Gly Glu Asp Lys 
    930                 935                 940                 


Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Tyr Thr Thr Tyr Thr 
945                 950                 955                 960 


Thr Thr Lys Asn Cys Asp Ile Gln Lys Asp Lys Ser Lys Leu Gln Gln 
                965                 970                 975     


Ser Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly Asn Thr 
            980                 985                 990         


Pro His Glu Tyr Lys Tyr Ala Cys  Gln Cys Lys Ile Pro  Thr Thr Glu 
        995                 1000                 1005             


Glu Thr  Cys Asp Asp Arg Lys  Glu Tyr Met Asn Gln  Trp Ile Ile 
    1010                 1015                 1020             


Asp Asn  Thr Lys Asn Pro Lys  Gly Ser Arg Ser Thr  Asn Asn Asp 
    1025                 1030                 1035             


Tyr Glu  Leu Tyr Thr Tyr Asn  Gly Val Lys Glu Thr  Lys Pro Leu 
    1040                 1045                 1050             


Gly Thr  Leu Lys Ser Ser Lys  Leu Asp Asp Lys Asp  Val Met Phe 
    1055                 1060                 1065             


Phe Asn  Leu Phe Glu Gln Trp  Asn Lys Glu Ile Gln  Tyr Glu Ile 
    1070                 1075                 1080             


Glu Gln  Tyr Met Thr Asn Thr  Lys Ile Ser Cys Asn  Asn Glu Met 
    1085                 1090                 1095             


Lys Val  Leu Ser Ser Ser Ser  Glu Glu Ser Gln Asn  Gln Asn Gly 
    1100                 1105                 1110             


Ser Asp  His His Asp Gly Arg  Asn Asn Asn Ile Asn  Gln Gly Thr 
    1115                 1120                 1125             


Asn Cys  Lys Lys Asn Cys Glu  Cys Tyr Ser Leu Trp  Met Glu Lys 
    1130                 1135                 1140             


Ile Lys  Lys Gln Trp Gly Lys  Gln Lys Asn Asn Tyr  Asn Lys Phe 
    1145                 1150                 1155             


Gln Arg  Lys Gln Ile Tyr Asp  Gly Asn Asn Ala Ser  His Lys Lys 
    1160                 1165                 1170             


Glu Ile  Val Lys Leu Ser Asn  Phe Leu Phe Phe Ser  Cys Trp Glu 
    1175                 1180                 1185             


Glu Tyr  Ile Gln Lys Tyr Phe  Asn Gly Asp Trp Ser  Lys Ile Lys 
    1190                 1195                 1200             


Asn Ile  Gly Ser Asp Thr Phe  Glu Tyr Leu Ile Lys  Lys Cys Gly 
    1205                 1210                 1215             


Asn Asp  Ser Gly Asp Gly Glu  Thr Ile Phe Asn Lys  Lys Leu Lys 
    1220                 1225                 1230             


Asn Ala  His Ile Lys Cys Asn  Glu Asn Glu Ser Thr  Asp Thr Lys 
    1235                 1240                 1245             


Ile Asn  Lys Ser Glu Thr Ser  Ser Asp Cys Ser Glu  Pro Ile Tyr 
    1250                 1255                 1260             


Ile Arg  Gly Cys Gln Ser Lys  Thr Tyr Asp Gly Phe  Ile Ser Pro 
    1265                 1270                 1275             


Gly Lys  Gly Gly Glu Lys Lys  Trp Ile Cys Lys Asp  Thr Ile Thr 
    1280                 1285                 1290             


His Gly  Asp Thr Asn Gly Ala  Cys Ile Pro Pro Arg  Thr Gln Asn 
    1295                 1300                 1305             


Leu Cys  Val Gly Glu Leu Trp  Asp Lys Arg Tyr Gly  Gly Arg Ser 
    1310                 1315                 1320             


Asn Ile  Lys Asn Asp Thr Lys  Glu Ser Leu Lys Asn  Lys Leu Lys 
    1325                 1330                 1335             


Asn Ala  Ile Gln Lys Glu Thr  Glu Leu Leu Tyr Glu  Tyr His Asp 
    1340                 1345                 1350             


Lys Gly  Thr Ala Ile Ile Ser  Gln Asn Asp Lys Lys  Glu Lys Ala 
    1355                 1360                 1365             


Asn Asn  Asn Asn Ser Asn Gly  Leu Pro Lys Gly Phe  Cys His Ala 
    1370                 1375                 1380             


Val Gln  Arg Ser Phe Ile Asp  Tyr Lys Asn Met Ile  Leu Gly Thr 
    1385                 1390                 1395             


Ser Val  Asn Thr Tyr Glu Tyr  Ile Gly Lys Leu Gln  Glu Asp Ile 
    1400                 1405                 1410             


Lys Lys  Ile Ile Glu Gln Gly  Arg Lys Pro Lys Glu  Lys Arg Val 
    1415                 1420                 1425             


Gly Ser  Gly Ala Asp Lys Val  Asn Asp Trp Trp Lys  Glu Ile Glu 
    1430                 1435                 1440             


Lys Asp  Met Trp Gly Ala Val  Lys Cys Gly Ile Lys  Thr Ile Lys 
    1445                 1450                 1455             


Lys Gln  Lys Lys Asn Gly Thr  Phe Ser Ile Asp Glu  Cys Gly Val 
    1460                 1465                 1470             


Ser Pro  Pro Thr Gly Asn Asp  Glu Asp Gln Phe Val  Ser Trp Phe 
    1475                 1480                 1485             


Lys Glu  Trp Gly Glu Gln Phe  Cys Ile Glu Arg Leu  Gln Tyr Glu 
    1490                 1495                 1500             


Lys Asn  Ile Arg Glu Ala Cys  Thr Ile Asn Gly Lys  Asn Glu Lys 
    1505                 1510                 1515             


Lys Cys  Ile Asn Ser Lys Ser  Gly Gln Glu Asp Lys  Ile Gln Gly 
    1520                 1525                 1530             


Ala Cys  Lys Arg Lys Cys Glu  Lys Tyr Lys Lys Tyr  Ile Ser Glu 
    1535                 1540                 1545             


Lys Lys  Gln Glu Trp Asp Lys  Gln Lys Thr Lys Tyr  Glu Asn Lys 
    1550                 1555                 1560             


Tyr Val  Gly Lys Ser Ala Ser  Asp Leu Leu Lys Glu  Asn Tyr Pro 
    1565                 1570                 1575             


Glu Cys  Ile Ser Ala Asn Phe  Asp Phe Ile Phe Asn  Asp Lys Ala 
    1580                 1585                 1590             


Asp His  Lys Lys Tyr Tyr Pro  Tyr Gly Asp Tyr Asn  Ser Ile Cys 
    1595                 1600                 1605             


Ser Cys  Glu Gln Val Lys Tyr  Tyr Glu Tyr Asn Lys  Asp Lys Gly 
    1610                 1615                 1620             


Gln Asn  Asn Lys Ser Leu Cys  His Glu Lys Gly Asn  Asp Arg Thr 
    1625                 1630                 1635             


Trp Ser  Lys Lys Tyr Ile Lys  Lys Leu Glu Asn Gly  Arg Ser Leu 
    1640                 1645                 1650             


Glu Gly  Val Tyr Val Pro Pro  Arg Arg Gln Gln Leu  Cys Leu Tyr 
    1655                 1660                 1665             


Glu Leu  Phe Pro Ile Ile Ile  Lys Lys Glu Lys Asp  Met Glu Lys 
    1670                 1675                 1680             


Ala Lys  Glu Glu Leu Leu Glu  Thr Leu Lys Ile Val  Ala Glu Arg 
    1685                 1690                 1695             


Glu Ala  Tyr Tyr Leu Trp Lys  Gln Tyr His Ala His  Asn Asp Thr 
    1700                 1705                 1710             


Thr Tyr  Leu Ala His Lys Lys  Ala Cys Cys Ala Ile  Arg Gly Ser 
    1715                 1720                 1725             


Phe Tyr  Asp Leu Glu Asp Ile  Ile Lys Gly Asn Asp  Leu Val His 
    1730                 1735                 1740             


Asp Glu  Tyr Thr Lys Tyr Ile  Asp Ser Lys Leu Asn  Glu Ile Phe 
    1745                 1750                 1755             


Gly Ser  Ser Asn Thr Asn Asn  Ile Asp Thr Lys Arg  Ala Arg Thr 
    1760                 1765                 1770             


Asp Trp  Trp Glu Asn Glu Thr  Ile Thr Asn Gly Pro  Asp Arg Lys 
    1775                 1780                 1785             


Thr Ile  Arg Gln Leu Val Trp  Asp Ala Met Gln Ser  Gly Val Arg 
    1790                 1795                 1800             


Tyr Ala  Val Glu Glu Lys Lys  Glu Asn Phe Pro Pro  Cys Met Gly 
    1805                 1810                 1815             


Val Glu  His Ile Gly Ile Ala  Lys Pro Gln Phe Ile  Arg Trp Leu 
    1820                 1825                 1830             


Glu Glu  Trp Thr Asn Glu Phe  Cys Glu Glu Tyr Thr  Lys Tyr Phe 
    1835                 1840                 1845             


Glu Asp  Met Lys Ser Lys Cys  Asp Pro Pro Lys Ser  Ala Asp Asp 
    1850                 1855                 1860             


Cys Gly  Asp Asn Thr Asn Ile  Glu Cys Lys Lys Ala  Cys Ala Asn 
    1865                 1870                 1875             


Tyr Thr  Asn Trp Leu Asn Pro  Lys Arg Ile Glu Trp  Asn Gly Met 
    1880                 1885                 1890             


Ser Asn  Tyr Tyr Asn Lys Ile  Tyr Arg Lys Ser Asn  Lys Glu Ser 
    1895                 1900                 1905             


Glu Asp  Gly Lys Asp Tyr Ser  Met Ile Met Glu Pro  Thr Val Ile 
    1910                 1915                 1920             


Asp Tyr  Leu Asn Lys Arg Cys  Asn Gly Glu Ile Asn  Gly Asn Tyr 
    1925                 1930                 1935             


Ile Cys  Cys Ser Cys Lys Asn  Ile Gly Ala Tyr Asn  Thr Thr Ser 
    1940                 1945                 1950             


Gly Thr  Val Asn Lys Lys Leu  Gln Lys Lys Glu Thr  Glu Cys Glu 
    1955                 1960                 1965             


Asp Asn  Lys Gly Pro Leu Asp  Leu Met Asn Glu Val  Leu Asn Lys 
    1970                 1975                 1980             


Met Asp  Glu Lys Tyr Ser Ala  His 
    1985                 1990     


<210>  26
<211>  1953
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26

Met Asp Lys Ser Ser Ile Gly Asp Lys Ile Glu Ala Tyr Leu Glu Lys 
1               5                   10                  15      


Lys Ser Asn Glu Ser Asp Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys Asn 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Ile Asp Glu Trp Lys 
65                  70                  75                  80  


Cys Gln Gln Asn Ser Ser Asp Gly Ser Gly Lys Pro Glu Asn Ile Cys 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
            100                 105                 110         


Lys Phe Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
                165                 170                 175     


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Leu Glu Lys 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Thr Lys 
        195                 200                 205             


Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
    210                 215                 220                 


Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Arg Trp 
225                 230                 235                 240 


Thr Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
                245                 250                 255     


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Tyr Leu Asp Tyr Val 
            260                 265                 270         


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Ala Asp Leu Tyr Arg 
        275                 280                 285             


Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His Arg Glu Glu Cys 
    290                 295                 300                 


Thr Arg Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Asn Met 
305                 310                 315                 320 


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
                325                 330                 335     


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Lys Asp Leu Tyr Glu Gln 
            340                 345                 350         


Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
        355                 360                 365             


Val Lys Glu Phe Phe Lys Lys Leu Glu Ala Asn Tyr Lys Ser Leu Asp 
    370                 375                 380                 


Asp Tyr Ile Lys Asp Asp Pro Tyr Ser Lys Glu Tyr Val Thr Lys Leu 
385                 390                 395                 400 


Ser Phe Ile Pro Asn Ser Ser Asp Thr Glu Asn Ala Ser Glu Lys Ile 
                405                 410                 415     


Gln Lys Asn Asn Asp Glu Val Cys Asn Pro Asn Glu Ser Gly Ile Ser 
            420                 425                 430         


Ser Val Gly Gln Ala Gln Thr Ser Gly Thr Ser Ser Asn Lys Thr Cys 
        435                 440                 445             


Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Val Cys Lys His 
    450                 455                 460                 


Val Lys Leu Gly Ile Asn Asn Asn Asp Lys Val Leu Arg Val Cys Val 
465                 470                 475                 480 


Ile Glu Asp Asp Ser Leu Arg Gly Val Asp Asn Cys Cys Cys Gln Asp 
                485                 490                 495     


Phe Leu Arg Met Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg Gly Ser 
            500                 505                 510         


Ser Ser Asn Asp Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
        515                 520                 525             


Asn Leu Asp Glu Ala Leu Ala Ser Leu Thr Asn Gly Tyr Lys Cys Asp 
    530                 535                 540                 


Lys Cys Lys Ser Gly Thr Ser Thr Val Asn Lys Asn Trp Ile Trp Arg 
545                 550                 555                 560 


Lys Ser Ser Gly Asn Lys Glu Gly Leu Gln Lys Glu Tyr Ala Asn Thr 
                565                 570                 575     


Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Cys Leu His 
            580                 585                 590         


Glu Lys Glu Gly Lys Thr Gln Glu Leu Lys Asn Ile Ser Thr Asn Ser 
        595                 600                 605             


Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly Lys Asn 
    610                 615                 620                 


Leu Lys Thr Thr Tyr Pro Gln Asn Lys Asn Ala Glu Asn Lys Lys Lys 
625                 630                 635                 640 


Leu Cys Lys Ala Leu Lys Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile 
                645                 650                 655     


Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu Leu 
            660                 665                 670         


Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys Lys 
        675                 680                 685             


Asn Asn Thr Ala Glu Gln His Thr Ser Tyr Ser Ser Leu Asp Glu Leu 
    690                 695                 700                 


Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Thr Ala Met 
705                 710                 715                 720 


Lys His Gly Ala Gly Met Asn Gly Thr Thr Cys Ser Ser Gly Ser Gly 
                725                 730                 735     


Asp Asn Gly Ser Ile Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu Ile 
            740                 745                 750         


Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe Cys Glu 
        755                 760                 765             


Gln Arg Gln Gly Lys Val Lys Asp Val Ile Thr Asn Cys Lys Ser Cys 
    770                 775                 780                 


Lys Glu Ser Gly Asp Thr Cys Lys Thr Glu Cys Lys Thr Lys Cys Lys 
785                 790                 795                 800 


Asp Glu Cys Glu Lys Tyr Lys Thr Phe Ile Glu Asp Cys Asn Gly Gly 
                805                 810                 815     


Gly Thr Gly Thr Ala Gly Ser Ser Trp Ser Lys Arg Trp Asp Gln Ile 
            820                 825                 830         


Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys 
        835                 840                 845             


Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Ser Thr Ala Glu 
    850                 855                 860                 


Ser Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile 
865                 870                 875                 880 


Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp 
                885                 890                 895     


Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr 
            900                 905                 910         


Tyr Thr Thr Thr Glu Asn Cys Asp Ile Gln Lys Lys Thr Pro Lys Ser 
        915                 920                 925             


Gln Ser Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly 
    930                 935                 940                 


Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Glu Cys Lys Ile Pro Thr 
945                 950                 955                 960 


Thr Glu Glu Ser Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp Ile 
                965                 970                 975     


Ser Asp Thr Ser Lys Lys Gln Lys Gly Ser Gly Ser Gly Lys Asp Asp 
            980                 985                 990         


Tyr Glu Leu Tyr Thr Tyr Asn Gly  Val Lys Glu Thr Lys  Leu Pro Lys 
        995                 1000                 1005             


Lys Leu  Asn Ser Thr Lys Leu  Asp Asp Lys Asp Val  Met Phe Phe 
    1010                 1015                 1020             


Asn Leu  Phe Glu Gln Trp Asn  Lys Glu Ile Gln Tyr  Gln Ile Glu 
    1025                 1030                 1035             


Gln Tyr  Met Thr Asn Ala Asn  Ile Ser Cys Asn Asn  Glu Met Asn 
    1040                 1045                 1050             


Val Leu  Ser Ser Ser Ser Glu  Glu Ser Gln Asn Gln  Lys Gly Ser 
    1055                 1060                 1065             


Asp His  His Val Gly Arg Asn  Asn Asn Thr Asp Gln  Gly Thr Asn 
    1070                 1075                 1080             


Cys Arg  Glu Lys Cys Glu Cys  Tyr Ser Leu Trp Ile  Glu Lys Ile 
    1085                 1090                 1095             


Lys Lys  Gln Trp Gly Lys Gln  Lys Asp Asn Tyr Asn  Lys Phe Gln 
    1100                 1105                 1110             


Arg Lys  Gln Ile Tyr Asp Gly  Asn Asn Ala Ser His  Lys Lys Glu 
    1115                 1120                 1125             


Ile Val  Lys Leu Ser Asn Phe  Leu Phe Phe Ser Cys  Trp Glu Glu 
    1130                 1135                 1140             


Tyr Ile  Gln Lys Tyr Phe Asn  Gly Asp Trp Ser Lys  Ile Lys Asn 
    1145                 1150                 1155             


Ile Gly  Ser Asp Thr Phe Glu  Phe Leu Ile Lys Lys  Cys Gly Asn 
    1160                 1165                 1170             


Asp Ser  Ala His Gly Glu Thr  Ile Phe Ser Glu Lys  Leu Lys Asn 
    1175                 1180                 1185             


Ala Gln  Gln Gln Cys Lys Glu  Ile Gln Asn Thr Asp  Thr Asn Ile 
    1190                 1195                 1200             


Asn Lys  Ser Gly Lys Ser Cys  Asp Leu Asn Ala Thr  Asn Tyr Ile 
    1205                 1210                 1215             


Arg Gly  Cys Gln Ser Lys Thr  Tyr Asp Gly Lys Ile  Phe Pro Gly 
    1220                 1225                 1230             


Lys Gly  Gly Glu Lys Gln Trp  Ile Cys Lys Asp Thr  Ile Ile His 
    1235                 1240                 1245             


Gly Asp  Thr Asn Gly Ala Cys  Ile Pro Pro Arg Thr  Gln Asn Leu 
    1250                 1255                 1260             


Cys Val  Gly Asn Leu Trp Asp  Lys Ser Tyr Gly Gly  Arg Ser Asn 
    1265                 1270                 1275             


Ile Lys  Asn Asp Thr Lys Glu  Ser Leu Lys Asn Lys  Leu Lys Asn 
    1280                 1285                 1290             


Ala Ile  Gln Lys Glu Thr Glu  Leu Leu Tyr Glu Tyr  His Asp Lys 
    1295                 1300                 1305             


Gly Thr  Ala Ile Ile Ser Gln  Asn Asp Lys Lys Gly  Glu Lys Gly 
    1310                 1315                 1320             


Lys Asn  Asp Pro Asn Gly Leu  Pro Lys Gly Phe Cys  His Ala Val 
    1325                 1330                 1335             


Gln Arg  Ser Phe Ile Asp Tyr  Lys Asn Met Ile Leu  Gly Thr Ser 
    1340                 1345                 1350             


Val Asn  Ile Tyr Glu Tyr Ile  Gly Lys Leu Gln Glu  Asp Ile Lys 
    1355                 1360                 1365             


Lys Ile  Ile Glu Gln Glu Arg  Thr Lys Thr Lys Glu  Lys Arg Val 
    1370                 1375                 1380             


Gly Ser  Gly Ala Glu Asn Val  Asn Ala Trp Trp Lys  Glu Ile Glu 
    1385                 1390                 1395             


Lys Asp  Met Trp Gly Ala Val  Lys Cys Gly Ile Lys  Thr Ile Lys 
    1400                 1405                 1410             


Lys Gln  Lys Lys Asn Gly Thr  Phe Asn Gly Asp Glu  Cys Gly Val 
    1415                 1420                 1425             


Ser Pro  Pro Thr Gly Asn Asp  Glu Asp Gln Phe Val  Ser Trp Phe 
    1430                 1435                 1440             


Lys Glu  Trp Gly Glu Gln Phe  Cys Ile Glu Arg Leu  Arg Tyr Glu 
    1445                 1450                 1455             


Gln Asn  Ile Arg Glu Ala Cys  Thr Ile Asn Gly Lys  Asn Gly Lys 
    1460                 1465                 1470             


Lys Cys  Ile Asn Ser Lys Ser  Gly Gln Gly Asp Lys  Ile Gln Gly 
    1475                 1480                 1485             


Asp Cys  Lys Arg Lys Cys Glu  Lys Tyr Lys Lys Tyr  Ile Ser Glu 
    1490                 1495                 1500             


Lys Lys  Gln Glu Trp Asp Lys  Gln Lys Thr Lys Tyr  Glu Asn Lys 
    1505                 1510                 1515             


Tyr Val  Gly Lys Ser Ala Ser  Asp Leu Leu Lys Glu  Asn Tyr Pro 
    1520                 1525                 1530             


Glu Cys  Ile Ser Ala Asn Phe  Asp Phe Ile Phe Asn  Asp Asn Ile 
    1535                 1540                 1545             


Glu Tyr  Lys Thr Tyr Tyr Pro  Tyr Gly Asp Tyr Asn  Ser Ile Cys 
    1550                 1555                 1560             


Ser Cys  Glu Gln Val Lys Tyr  Tyr Lys Tyr Asn Asn  Ala Glu Lys 
    1565                 1570                 1575             


Lys Asn  Asn Lys Ser Leu Cys  His Glu Lys Gly Asn  Asp Arg Thr 
    1580                 1585                 1590             


Trp Ser  Lys Lys Tyr Ile Lys  Lys Leu Glu Asn Gly  Arg Ser Leu 
    1595                 1600                 1605             


Glu Gly  Val Tyr Val Pro Pro  Arg Arg Gln Gln Leu  Cys Leu Tyr 
    1610                 1615                 1620             


Glu Leu  Phe Pro Ile Ile Ile  Lys Lys Glu Lys Asp  Met Glu Asn 
    1625                 1630                 1635             


Val Lys  Lys Glu Leu Leu Glu  Thr Leu Gln Ile Val  Ala Glu Arg 
    1640                 1645                 1650             


Glu Ala  Tyr Tyr Leu Trp Lys  Gln Tyr Asn Pro Thr  Gly Lys Gly 
    1655                 1660                 1665             


Ile Asp  Asp Ala Asn Lys Lys  Ala Cys Cys Ala Ile  Arg Gly Ser 
    1670                 1675                 1680             


Phe Tyr  Asp Leu Glu Asp Ile  Ile Lys Gly Asn Asp  Leu Val His 
    1685                 1690                 1695             


Asp Glu  Tyr Thr Lys Tyr Ile  Asp Ser Lys Leu Asn  Glu Ile Phe 
    1700                 1705                 1710             


Gly Ser  Ser Asn Lys Asn Asp  Ile Asp Thr Lys Arg  Ala Arg Thr 
    1715                 1720                 1725             


Asp Trp  Trp Glu Asn Glu Thr  Phe Gln Val Ser Asn  Ile Thr Gly 
    1730                 1735                 1740             


Ala Asn  Lys Ser Asp Pro Lys  Thr Ile Arg Gln Leu  Val Trp Asp 
    1745                 1750                 1755             


Ala Met  Gln Ser Gly Val Arg  Tyr Ala Val Glu Glu  Lys Asn Glu 
    1760                 1765                 1770             


Asn Phe  Pro Pro Cys Met Gly  Val Glu His Ile Gly  Ile Ala Lys 
    1775                 1780                 1785             


Pro Gln  Phe Ile Arg Trp Leu  Glu Glu Trp Thr Asn  Glu Phe Cys 
    1790                 1795                 1800             


Glu Lys  Tyr Thr Lys Tyr Phe  Glu Asp Met Lys Ser  Asn Cys Asn 
    1805                 1810                 1815             


Arg Arg  Lys Gly Ala Asp Thr  Cys Gly Asp Asn Ser  Asn Ile Glu 
    1820                 1825                 1830             


Cys Lys  Arg Ala Cys Ala Asn  Tyr Thr Asn Trp Leu  Asn Pro Lys 
    1835                 1840                 1845             


Arg Ile  Glu Trp Asn Gly Met  Ser Asn Tyr Tyr Asn  Lys Ile Tyr 
    1850                 1855                 1860             


Arg Lys  Ser Asn Lys Glu Ser  Glu Asp Gly Lys Asp  Tyr Ser Met 
    1865                 1870                 1875             


Ile Met  Glu Pro Thr Val Ile  Asp Tyr Leu Asn Lys  Arg Cys His 
    1880                 1885                 1890             


Gly Glu  Ile Asn Gly Asn Tyr  Ile Cys Cys Ser Cys  Lys Asn Ile 
    1895                 1900                 1905             


Gly Glu  Tyr Asn Ser Thr Ser  Gly Thr Val Asn Lys  Lys Leu Gln 
    1910                 1915                 1920             


Lys Lys  Glu Thr Glu Cys Glu  Glu Glu Lys Gly Pro  Leu Asp Leu 
    1925                 1930                 1935             


Met Asn  Glu Val Leu Asn Lys  Met Asp Glu Lys Tyr  Ser Ala His 
    1940                 1945                 1950             


<210>  27
<211>  1977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27

Met Asp Lys Ser Ser Ile Ala Asn Lys Ile Glu Glu Tyr Leu Lys Glu 
1               5                   10                  15      


Lys Ser Asp Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys Asn 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Glu Lys Lys Leu Leu Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Asp Glu Asn Leu Ser Lys Val Ser Gly Lys Pro Glu Asn Ile Cys 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
            100                 105                 110         


Lys Phe Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Lys Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Leu Ala Asp Ile Ile Arg Gly Arg Asp Gly Asn Lys Cys Glu Thr Lys 
                165                 170                 175     


Ser Pro Asn Asn Val Glu Glu Leu Ile Lys Lys Phe Phe Glu Lys Asn 
            180                 185                 190         


Tyr Arg Ser Asn Glu Glu Tyr Arg Lys Lys Tyr Pro Asn Asp Asp Glu 
        195                 200                 205             


Asn Tyr Lys Lys Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys 
    210                 215                 220                 


Val Trp Glu Val Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile 
225                 230                 235                 240 


Lys Arg Arg Trp Arg Thr Ser Lys Glu Ser Asn Gly Glu Asn Lys Leu 
                245                 250                 255     


Glu Leu Cys Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Lys 
            260                 265                 270         


Leu Asp Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu 
        275                 280                 285             


Asp Phe Tyr Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His 
    290                 295                 300                 


Arg Glu Glu Cys Thr Arg Glu Asp Asp Lys Cys Lys Glu Gly Thr Ser 
305                 310                 315                 320 


Tyr Cys Asn Met Cys Lys Glu Lys His Thr Lys Tyr Cys Glu Cys Val 
                325                 330                 335     


Lys Lys Trp Lys Thr Glu Trp Glu Asn Gln Glu Asn Lys Tyr Thr Glu 
            340                 345                 350         


Leu Tyr Glu Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg 
        355                 360                 365             


Tyr Asp Asp Asn Val Lys Glu Phe Phe Glu Lys Leu Lys Gly Asn Gly 
    370                 375                 380                 


Tyr Ser Ser Ala Asn Ser Tyr Val Lys Asn Asn Pro Tyr Ser Ser Glu 
385                 390                 395                 400 


Asp Gly Lys Leu Leu Lys Phe Asp Asn Thr Asn Ala Phe Lys Glu Ser 
                405                 410                 415     


Ile Thr Cys Asn Lys Asn Val Cys Ser Cys Ser Gly Asn Glu Lys Leu 
            420                 425                 430         


Ile Ile Ser Glu Gly Ser Leu Ser Ser Ser Ser Phe Gly Thr Ser Ser 
        435                 440                 445             


Ser Tyr Gln Ser Ser Ile Ile Thr Ser Lys Lys Arg Asn Glu Cys Ala 
    450                 455                 460                 


Gln Ile Lys Phe Ser Gly Asn Glu Asn Asn Met Asn Ile Lys Ile Cys 
465                 470                 475                 480 


Ser Thr Gln Asp Asn Asn Leu Leu Val Lys Leu Glu Asp Leu Leu Lys 
                485                 490                 495     


Gly Phe Cys Asp Thr Cys Asp Thr Gly Ile Gly Val Glu Val Val Ser 
            500                 505                 510         


Glu Asn Asn Cys Glu Glu Gln Tyr Lys Lys Leu Leu Pro Ser Leu Glu 
        515                 520                 525             


Lys Cys Thr Val Leu Asn Cys Asn Glu Cys Asn Lys Thr Val Phe Lys 
    530                 535                 540                 


Asn Leu Lys Lys Gln Gln Glu Lys Trp Ile Trp Gly Lys Pro Lys Gln 
545                 550                 555                 560 


Glu Ala Ala Gly Leu Gln Glu Glu Tyr Ala Asn Thr Ile Gly Leu Pro 
                565                 570                 575     


Pro Arg Thr Gln Leu Leu Tyr Leu Val Cys Leu His Glu Lys Glu Gly 
            580                 585                 590         


Lys Thr Gln Glu Leu Lys Asn Ile Ser Thr Asn Ser Glu Leu Leu Lys 
        595                 600                 605             


Glu Trp Ile Ile Ala Ala Phe His Glu Gly Lys Asn Leu Lys Pro Ser 
    610                 615                 620                 


His Gln Asn Lys Asn Asp Asp Asn Gly Lys Lys Leu Cys Lys Asp Leu 
625                 630                 635                 640 


Lys Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile 
                645                 650                 655     


Trp Asp Asn Asp Phe Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ile 
            660                 665                 670         


Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys Lys Asn Ile Ser Thr Glu 
        675                 680                 685             


Gln Asp Thr Leu Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp 
    690                 695                 700                 


Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala Met Lys His Gly Ala Gly 
705                 710                 715                 720 


Met Asn Ser Thr Thr Cys Asn Gly Asp Gly Ser Val Thr Gly Ser Ser 
                725                 730                 735     


Asp Ser Gly Ser Thr Thr Cys Ser Gly Asp Asn Gly Ser Ile Ser Cys 
            740                 745                 750         


Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu 
        755                 760                 765             


Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg Gln Glu Lys Val Asn 
    770                 775                 780                 


Ala Val Ile Thr Asn Cys Lys Ser Cys Lys Asn Thr Ser Gly Glu Arg 
785                 790                 795                 800 


Lys Ile Gly Asp Thr Cys Gly Asn Asp Cys Glu Lys Lys Cys Lys Val 
                805                 810                 815     


Ala Cys Asp Ala Tyr Lys Glu Phe Ile Glu Glu Cys Arg Thr Ala Ala 
            820                 825                 830         


Glu Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln Ile Tyr 
        835                 840                 845             


Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala 
    850                 855                 860                 


Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala Glu Ser 
865                 870                 875                 880 


Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp 
                885                 890                 895     


Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp Glu 
            900                 905                 910         


Asn Asn Cys Gly Glu Asp Asn Ala Pro Trp Thr Thr Tyr Thr Thr Tyr 
        915                 920                 925             


Thr Thr Thr Lys Asn Cys Asp Ile Gln Lys Asp Lys Ser Lys Ser Gln 
    930                 935                 940                 


Ser Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
945                 950                 955                 960 


Thr Pro His Gly Tyr Lys Tyr Ala Cys Glu Cys Arg Thr Pro Asn Lys 
                965                 970                 975     


Gln Glu Thr Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp Ile Ile 
            980                 985                 990         


Asp Asn Thr Lys Asn Pro Lys Gly  Ser Gly Ser Gly Lys  Asp Tyr Tyr 
        995                 1000                 1005             


Glu Leu  Cys Lys Tyr Asn Gly  Val Lys Glu Thr Lys  Leu Pro Lys 
    1010                 1015                 1020             


Lys Leu  Asn Ser Ser Lys Leu  Asp Asp Lys Asp Val  Met Phe Phe 
    1025                 1030                 1035             


Asn Leu  Phe Glu Gln Trp Asn  Lys Glu Ile Gln Tyr  Gln Ile Glu 
    1040                 1045                 1050             


Gln Tyr  Met Thr Tyr Ala Asn  Ile Ser Cys Asn Asn  Glu Met Asn 
    1055                 1060                 1065             


Val Leu  Ser Ser Ser Ser Glu  Glu Ser Gln Asn Gln  Asn Gly Ser 
    1070                 1075                 1080             


Asp His  His Asp Gly Arg Asn  Asn Asn Thr Asp Gln  Gly Thr Asn 
    1085                 1090                 1095             


Cys Arg  Glu Lys Cys Lys Cys  Tyr Ser Leu Trp Ile  Glu Lys Ile 
    1100                 1105                 1110             


Lys Lys  Gln Trp Gly Lys Gln  Lys Asn Asn Tyr Asn  Lys Phe Glu 
    1115                 1120                 1125             


Lys Lys  Thr Ser Ser Tyr Ala  Asn Lys Gly Pro Gln  Asn Lys Lys 
    1130                 1135                 1140             


Val Val  Ser Leu Ser His Phe  Leu Phe Phe Ser Cys  Trp Glu Glu 
    1145                 1150                 1155             


Tyr Ile  Gln Lys Tyr Phe Asn  Gly Asp Trp Ser Lys  Ile Lys Asn 
    1160                 1165                 1170             


Ile Gly  Ser Asp Thr Phe Glu  Phe Leu Ile Lys Lys  Cys Gly Asn 
    1175                 1180                 1185             


Asp Ser  Ala His Gly Glu Thr  Ile Phe Ser Glu Lys  Leu Asn Asn 
    1190                 1195                 1200             


Ala His  Ile Lys Cys Asn Glu  Asn Ala Ser Lys Asn  Thr Lys Ile 
    1205                 1210                 1215             


Asn Pro  Ser Val Ile Ser Ser  Asp Cys Ser Glu Pro  Ile Tyr Ile 
    1220                 1225                 1230             


Arg Gly  Cys Gln Ser Lys Thr  Tyr Asp Gly Phe Ile  Ser Pro Gly 
    1235                 1240                 1245             


Lys Gly  Gly Glu Lys Gln Trp  Ile Cys Lys Asp Thr  Ile Thr His 
    1250                 1255                 1260             


Gly Asp  Thr Asn Gly Ala Cys  Ile Pro Pro Arg Thr  Gln Asn Leu 
    1265                 1270                 1275             


Cys Val  Gly Asn Leu Trp Asp  Lys Ser Tyr Gly Gly  Arg Ser Asn 
    1280                 1285                 1290             


Ile Lys  Asn Asp Thr Lys Glu  Ser Leu Lys Asn Lys  Leu Lys Asn 
    1295                 1300                 1305             


Ala Ile  Gln Lys Glu Thr Glu  Leu Leu Tyr Glu Tyr  His Asp Lys 
    1310                 1315                 1320             


Gly Thr  Ala Thr Ile Ser Arg  Asn Pro Met Lys Glu  Gly Gly Glu 
    1325                 1330                 1335             


Asp Gly  Lys Gly Lys Gln Lys  Glu Gly Gly Glu Lys  Ala Asn Asn 
    1340                 1345                 1350             


Asn Asn  Ser Asn Gly Leu Pro  Lys Gly Phe Cys His  Ala Val Gln 
    1355                 1360                 1365             


Arg Ser  Phe Ile Asp Tyr Lys  Asn Met Ile Leu Gly  Thr Ser Val 
    1370                 1375                 1380             


Asn Ile  Tyr Glu Tyr Ile Gly  Lys Leu Gln Glu Asp  Ile Lys Lys 
    1385                 1390                 1395             


Ile Ile  Glu Gln Glu Thr Pro  Gln Gln Asn Gly Lys  Thr Val Gly 
    1400                 1405                 1410             


Ser Gly  Ala Asp Lys Val Asn  Asp Trp Trp Lys Glu  Ile Glu Lys 
    1415                 1420                 1425             


Asp Met  Trp Gly Ala Val Lys  Cys Gly Ile Thr Lys  Ile Asn Lys 
    1430                 1435                 1440             


Lys Gln  Lys Lys Asn Gly Thr  Tyr Thr Gly Asp Glu  Cys Gly Val 
    1445                 1450                 1455             


Ser Pro  Pro Thr Gly Asn Asp  Glu Asp Gln Phe Val  Ser Trp Phe 
    1460                 1465                 1470             


Lys Glu  Trp Gly Glu Gln Phe  Cys Ile Glu Arg Leu  Gln Tyr Glu 
    1475                 1480                 1485             


Lys Asn  Ile Arg Asp Ala Cys  Thr Asn Asn Gly Gln  Gly Asp Lys 
    1490                 1495                 1500             


Ile Gln  Gly Ala Cys Lys Arg  Lys Cys Glu Lys Tyr  Lys Lys Tyr 
    1505                 1510                 1515             


Ile Ser  Glu Lys Lys Lys Glu  Trp Asp Lys Gln Lys  Thr Lys Tyr 
    1520                 1525                 1530             


Glu Asn  Lys Tyr Val Gly Lys  Ser Ala Ser Asp Leu  Leu Lys Glu 
    1535                 1540                 1545             


Asn Tyr  Pro Glu Cys Ile Ser  Ala Asn Phe Asp Phe  Ile Phe Asn 
    1550                 1555                 1560             


Asp Asn  Ile Glu Tyr Lys Thr  Tyr Tyr Pro Tyr Gly  Asp Tyr Ser 
    1565                 1570                 1575             


Ser Ile  Cys Ser Cys Glu Gln  Val Lys Tyr Tyr Lys  Tyr Asn Lys 
    1580                 1585                 1590             


Asp Lys  Gly Gln Asn Asn Lys  Ser Leu Cys His Glu  Lys Gly Asn 
    1595                 1600                 1605             


Asp Arg  Thr Trp Ser Lys Lys  Tyr Ile Lys Lys Leu  Glu Asn Gly 
    1610                 1615                 1620             


Arg Ser  Leu Glu Gly Val Tyr  Val Pro Pro Gly Arg  Gln Gln Leu 
    1625                 1630                 1635             


Cys Leu  Tyr Glu Leu Phe Pro  Ile Ile Ile Lys Asn  Glu Glu Gly 
    1640                 1645                 1650             


Met Glu  Lys Ala Lys Lys Glu  Leu Leu Glu Thr Leu  Gln Ile Val 
    1655                 1660                 1665             


Ala Glu  Arg Glu Ala Tyr Tyr  Leu Trp Lys Gln Tyr  His Ala His 
    1670                 1675                 1680             


Asn Asp  Thr Thr Tyr Leu Ala  His Lys Lys Ala Cys  Cys Ala Ile 
    1685                 1690                 1695             


Arg Gly  Ser Phe Tyr Asp Leu  Glu Asp Ile Ile Lys  Gly Asn Asp 
    1700                 1705                 1710             


Leu Val  His Asp Glu Tyr Thr  Lys Tyr Ile Asp Ser  Lys Leu Asn 
    1715                 1720                 1725             


Lys Ile  Phe Gly Ser Ser Asn  Thr Asn Asn Ile Glu  Thr Lys Arg 
    1730                 1735                 1740             


Ala Arg  Thr Asp Trp Trp Glu  Asn Lys Thr Ile Asp  Val Pro Asn 
    1745                 1750                 1755             


Ile Thr  Asp Ala Asn Lys Ser  Asp Ser Lys Thr Ile  Arg Gln Leu 
    1760                 1765                 1770             


Val Trp  Asp Ala Met Gln Ser  Gly Val Arg Lys Ala  Ile Asp Glu 
    1775                 1780                 1785             


Glu Asn  Glu Lys Lys Lys Pro  Asn Glu Asn Phe Pro  Pro Cys Met 
    1790                 1795                 1800             


Gly Val  Glu His Ile Gly Ile  Ala Lys Pro Gln Phe  Ile Arg Trp 
    1805                 1810                 1815             


Leu Glu  Glu Trp Thr Asn Glu  Phe Cys Glu Lys Tyr  Thr Lys Tyr 
    1820                 1825                 1830             


Phe Glu  Asp Met Lys Ser Asn  Cys Asp Pro Pro Lys  Ser Ala Asp 
    1835                 1840                 1845             


Asp Cys  Gly Asp Asn Thr Asn  Ile Glu Cys Lys Lys  Ala Cys Ala 
    1850                 1855                 1860             


Asn Tyr  Thr Asn Trp Leu Asn  Pro Lys Arg Ile Glu  Trp Asn Gly 
    1865                 1870                 1875             


Met Ser  Asn Tyr Tyr Asn Lys  Ile Tyr Arg Lys Ser  Asn Lys Glu 
    1880                 1885                 1890             


Ser Glu  Asp Gly Lys Asp Tyr  Ser Met Ile Met Glu  Pro Thr Val 
    1895                 1900                 1905             


Ile Asp  Tyr Leu Asn Lys Arg  Cys His Gly Glu Ile  Asn Gly Asn 
    1910                 1915                 1920             


Tyr Ile  Cys Cys Ser Cys Lys  Asn Ile Gly Ala Tyr  Asn Thr Thr 
    1925                 1930                 1935             


Ser Gly  Thr Val Asn Lys Lys  Leu Gln Lys Lys Glu  Thr Glu Cys 
    1940                 1945                 1950             


Glu Asp  Asn Lys Gly Pro Leu  Asp Leu Met Asn Glu  Val Leu Asn 
    1955                 1960                 1965             


Lys Met  Asp Pro Lys Tyr Ser  Lys Leu 
    1970                 1975         


<210>  28
<211>  1999
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28

Met Asp Ser Thr Ser Thr Ile Ala Asp Lys Ile Glu Glu Tyr Leu Glu 
1               5                   10                  15      


Lys Lys Ser Asp Glu Ser Asn Ile Glu Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Glu Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Gly Asn His Lys Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys 
            100                 105                 110         


Leu Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Arg Asp Glu Asn Lys Cys Glu Thr 
                165                 170                 175     


Lys Ser Thr Asn Asn Val Glu Glu Leu Ile Lys Asn Phe Phe Gly Lys 
            180                 185                 190         


Asn Tyr Arg Ser Asn Glu Glu Tyr Lys Arg Lys Tyr Arg Asn Asp Asp 
        195                 200                 205             


Pro Lys Tyr Thr Lys Leu Arg Glu Ser Trp Trp Thr Lys Asn Arg Gln 
    210                 215                 220                 


Lys Val Trp Glu Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu 
225                 230                 235                 240 


Ile Lys Arg Gly Trp Arg Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys 
                245                 250                 255     


Leu Glu Leu Phe Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr 
            260                 265                 270         


Lys Leu Asp Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile 
        275                 280                 285             


Glu Asp Leu Tyr Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg 
    290                 295                 300                 


His Arg Glu Glu Cys Thr Ser Glu Asp Asp Lys Cys Lys Glu Val Thr 
305                 310                 315                 320 


Ser Tyr Cys Ser Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Phe 
                325                 330                 335     


Val Lys Lys Trp Lys Ser Glu Trp Lys Asn Gln Lys Asn Lys Tyr Thr 
            340                 345                 350         


Glu Leu Tyr Glu Gln Asn Lys Asn Lys Thr Ser Ser Ser Ser Lys Asn 
        355                 360                 365             


Thr Ser Arg Tyr Asp Asp Tyr Val Lys Glu Phe Phe Lys Lys Leu Asn 
    370                 375                 380                 


Glu Ala Asn Tyr Lys Ser Leu Asp Asp Tyr Ile Lys Gly Asp Pro Tyr 
385                 390                 395                 400 


Ser Ala Glu Tyr Val Thr Lys Leu Ser Phe Ile Leu Asn Pro Ser Asp 
                405                 410                 415     


Ala Asn Asn Pro Ser Gly Glu Thr Ala Asn His Asn Asp Glu Val Cys 
            420                 425                 430         


Asn Cys Asn Glu Ser Glu Ile Ala Cys Val Glu Leu Ala Gln Thr Ser 
        435                 440                 445             


Gly Ser Ser Ser Asn Lys Thr Cys Ile Thr His Ser Ser Ile Lys Ala 
    450                 455                 460                 


Asn Lys Lys Lys Val Cys Lys Asp Val Lys Leu Gly Ile Asn Asn Asn 
465                 470                 475                 480 


Asp Lys Asp Leu Lys Ile Cys Val Ile Glu Asp Thr Ser Leu Ser Gly 
                485                 490                 495     


Val Glu Asn Cys Cys Cys Gln Asp Phe Leu Arg Met Leu Gln Glu Asn 
            500                 505                 510         


Cys Ser Asp Asn Lys Ser Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn 
        515                 520                 525             


Asn Asn Glu Asp Glu Cys Gln Lys Lys Leu Glu Lys Val Phe Ala Ser 
    530                 535                 540                 


Leu Thr Asn Gly Tyr Lys Cys Asp Lys Cys Lys Ser Glu Gln Ser Lys 
545                 550                 555                 560 


Lys Asn Asn Asn Ile Trp Ile Trp Arg Lys Ser Ser Gly Asp Glu Lys 
                565                 570                 575     


Gly Leu Gln Lys Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr 
            580                 585                 590         


Gln Ser Leu Tyr Leu Gly Asn Leu Pro Lys Leu Glu Asn Val Cys Glu 
        595                 600                 605             


Asp Val Thr Asp Ile Asn Phe Asp Thr Lys Glu Lys Phe Leu Ala Gly 
    610                 615                 620                 


Cys Leu Ile Ala Ala Phe His Glu Gly Lys Asn Leu Lys Lys Arg Tyr 
625                 630                 635                 640 


His Gln Asn Lys Asn Asp Glu Asn Lys Lys Lys Leu Cys Lys Ala Leu 
                645                 650                 655     


Lys Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile 
            660                 665                 670         


Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ile 
        675                 680                 685             


Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys Lys Asn Ile Ser Thr Glu 
    690                 695                 700                 


Gln Asp Thr Leu Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp 
705                 710                 715                 720 


Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala Met Lys His Gly Thr Thr 
                725                 730                 735     


Cys Ser Ser Gly Ser Gly Asp Asn Gly Asp Gly Ser Val Thr Gly Ser 
            740                 745                 750         


Ser Asp Ser Gly Ser Thr Thr Cys Cys Gly Asp Gly Ser Val Thr Gly 
        755                 760                 765             


Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln 
    770                 775                 780                 


Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg 
785                 790                 795                 800 


Gln Glu Lys Val Asn Ala Val Ile Asn Ser Cys Asn Ser Cys Lys Asn 
                805                 810                 815     


Thr Ser Ser Lys Thr Lys Leu Gly Asp Thr Cys Lys Thr Glu Cys Lys 
            820                 825                 830         


Asn Lys Cys Glu Ala Tyr Lys Asn Phe Ile Glu Asp Cys Lys Gly Gly 
        835                 840                 845             


Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Tyr Gln Ile Tyr 
    850                 855                 860                 


Met Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala 
865                 870                 875                 880 


Gly Thr Lys Ser Cys Gly Thr Ser Ser Gly Ala Thr Ser Gly Val Thr 
                885                 890                 895     


Thr Thr Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys 
            900                 905                 910         


His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile 
        915                 920                 925             


Val Leu Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr 
    930                 935                 940                 


Tyr Thr Thr Tyr Thr Thr Lys Asn Cys Asp Lys Asp Lys Lys Lys Ser 
945                 950                 955                 960 


Lys Ser Gln Ser Cys Asp Thr Leu Val Val Val Asn Val Pro Ser Pro 
                965                 970                 975     


Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Val Cys Glu Cys Arg Thr 
            980                 985                 990         


Pro Ser Asn Lys Glu Leu Cys Asp  Asp Arg Lys Glu Tyr  Met Asn Gln 
        995                 1000                 1005             


Trp Ile  Ser Asp Thr Ser Lys  Asn Pro Lys Gly Gly  Arg Ser Thr 
    1010                 1015                 1020             


Asn Asn  Asp Tyr Glu Leu Tyr  Thr Tyr Asn Gly Val  Asp Val Lys 
    1025                 1030                 1035             


Pro Thr  Thr Val Arg Ser Asn  Ser Thr Lys Leu Asp  Asp Lys Asp 
    1040                 1045                 1050             


Val Met  Phe Phe Asn Leu Phe  Glu Gln Trp Asn Lys  Glu Ile Gln 
    1055                 1060                 1065             


Tyr Gln  Ile Glu Gln Tyr Met  Thr Asn Thr Lys Ile  Ser Cys Asn 
    1070                 1075                 1080             


Asn Glu  Met Lys Val Leu Ser  Arg Val Ser Glu Glu  Ser Lys Asn 
    1085                 1090                 1095             


Gln Asn  Ser Ser Asp Asp His  Asp Gly Gly Asn Asn  Asn Thr Asp 
    1100                 1105                 1110             


Gln Gly  Thr Asn Cys Lys Glu  Lys Cys Glu Cys Tyr  Lys Leu Trp 
    1115                 1120                 1125             


Ile Glu  Lys Ile Lys Glu Gln  Trp Asp Lys Gln Lys  Lys Asn Tyr 
    1130                 1135                 1140             


Asn Lys  Phe Glu Lys Lys Thr  Ser Asn Asp Ala Arg  Lys Ser Ser 
    1145                 1150                 1155             


Gln Asn  Lys Lys Val Val Ser  Leu Ser His Phe Leu  Phe Phe Ser 
    1160                 1165                 1170             


Cys Trp  Glu Glu Tyr Ile Gln  Lys Tyr Phe Asn Gly  Asp Trp Ser 
    1175                 1180                 1185             


Lys Ile  Lys Asn Ile Gly Ser  Asp Thr Phe Glu Phe  Leu Ile Lys 
    1190                 1195                 1200             


Lys Cys  Gly Asn Asn Ser Gly  Asp Gly Glu Thr Ile  Phe Ser Glu 
    1205                 1210                 1215             


Lys Leu  Asn Asn Ala Asn Ile  Lys Cys Asn Glu Asn  Glu Ser Thr 
    1220                 1225                 1230             


Asp Thr  Lys Ile Asn Lys Ser  Glu Thr Ser Cys Asp  Leu Asn Ala 
    1235                 1240                 1245             


Thr Asn  Tyr Ile Arg Gly Cys  Gln Ser Lys Thr Tyr  Asp Gly Lys 
    1250                 1255                 1260             


Ile Phe  Pro Gly Lys Gly Gly  Glu Lys Gln Trp Ile  Cys Lys Asp 
    1265                 1270                 1275             


Thr Ile  Ile His Gly Asp Thr  Asn Gly Ala Cys Ile  Pro Pro Arg 
    1280                 1285                 1290             


Thr Gln  Asn Leu Cys Val Gly  Glu Leu Trp Asp Lys  Arg Tyr Gly 
    1295                 1300                 1305             


Gly Arg  Ser Asn Ile Lys Asn  Asp Thr Lys Glu Ser  Leu Lys Asn 
    1310                 1315                 1320             


Lys Leu  Lys Asn Ala Ile Gln  Lys Glu Thr Glu Leu  Leu Tyr Glu 
    1325                 1330                 1335             


Tyr His  Asp Lys Gly Thr Ala  Thr Ile Ser Arg Asn  Pro Met Lys 
    1340                 1345                 1350             


Glu Gly  Gly Glu Asp Gly Lys  Gly Lys Gln Lys Glu  Gly Gly Glu 
    1355                 1360                 1365             


Lys Ala  Asn Asn Asn Lys Asn  Ser Asn Gly Leu Pro  Lys Gly Phe 
    1370                 1375                 1380             


Cys His  Ala Val Gln Arg Ser  Phe Ile Asp Tyr Lys  Asn Met Ile 
    1385                 1390                 1395             


Leu Gly  Thr Ser Val Asn Ile  Tyr Glu Tyr Ile Gly  Lys Leu Gln 
    1400                 1405                 1410             


Glu Asp  Ile Lys Lys Ile Ile  Glu Lys Gly Thr Thr  Lys Gln Asn 
    1415                 1420                 1425             


Gly Lys  Thr Val Gly Ser Gly  Ala Asp Lys Val Asn  Asp Trp Trp 
    1430                 1435                 1440             


Lys Glu  Ile Glu Lys Asp Met  Trp Gly Ala Val Lys  Cys Gly Ile 
    1445                 1450                 1455             


Lys Thr  Ile Lys Lys Gln Asn  Asn Lys Cys Thr Tyr  Thr Gly Asp 
    1460                 1465                 1470             


Glu Cys  Gly Ile Phe Pro Pro  Thr Gly Asn Asp Glu  Asp Gln Phe 
    1475                 1480                 1485             


Val Ser  Trp Phe Lys Glu Trp  Gly Glu Gln Phe Cys  Ile Glu Arg 
    1490                 1495                 1500             


Leu Gln  Tyr Glu Gln Asn Ile  Arg Asp Ala Cys Ile  Asn Asn Gly 
    1505                 1510                 1515             


Lys Asn  Glu Lys Lys Cys Ile  Asn Ser Lys Ser Gly  Gln Gly Asp 
    1520                 1525                 1530             


Lys Val  Glu Gly Ala Cys Lys  Arg Lys Cys Glu Glu  Tyr Lys Lys 
    1535                 1540                 1545             


Tyr Ile  Ser Glu Lys Lys Lys  Glu Trp Asp Lys Gln  Lys Thr Lys 
    1550                 1555                 1560             


Tyr Glu  Asn Lys Tyr Val Gly  Lys Ser Ala Ser Asp  Leu Leu Lys 
    1565                 1570                 1575             


Glu Asn  Tyr Pro Glu Cys Ile  Ser Ala Asn Phe Asp  Phe Ile Phe 
    1580                 1585                 1590             


Asn Asp  Asn Ile Glu Tyr Lys  Thr Tyr Tyr Pro Tyr  Gly Asp Tyr 
    1595                 1600                 1605             


Ser Ser  Ile Cys Ser Cys Glu  Gln Val Lys Tyr Tyr  Glu Tyr Ile 
    1610                 1615                 1620             


Lys Asp  Lys Gly Gln Asn Asn  Lys Ser Leu Cys His  Glu Lys Gly 
    1625                 1630                 1635             


Asn Asp  Arg Thr Trp Ser Lys  Lys Tyr Ile Lys Lys  Leu Glu Asn 
    1640                 1645                 1650             


Gly Arg  Thr Leu Glu Gly Val  Tyr Val Pro Pro Arg  Arg Gln Gln 
    1655                 1660                 1665             


Leu Cys  Leu Tyr Glu Leu Phe  Pro Ile Ile Ile Lys  Lys Glu Asn 
    1670                 1675                 1680             


Asp Ile  Thr Asn Ala Lys Lys  Glu Leu Leu Glu Thr  Leu Gln Ile 
    1685                 1690                 1695             


Val Ala  Glu Arg Glu Ala Tyr  Tyr Leu Trp Lys Gln  Tyr Asn Pro 
    1700                 1705                 1710             


Thr Gly  Lys Gly Ile Asp Asp  Ala Asn Lys Lys Ala  His Lys Lys 
    1715                 1720                 1725             


Ala Cys  Cys Ala Ile Arg Gly  Ser Phe Tyr Asp Leu  Glu Asp Ile 
    1730                 1735                 1740             


Ile Lys  Gly Asn Asp Leu Val  His Asp Glu Tyr Thr  Lys Tyr Ile 
    1745                 1750                 1755             


Asp Ser  Lys Leu Asn Lys Ile  Phe Gly Ser Ser Asn  Thr Asn Asn 
    1760                 1765                 1770             


Ile Asp  Thr Lys Arg Ala Arg  Thr Asp Trp Trp Glu  Asn Glu Ile 
    1775                 1780                 1785             


Ile Thr  Asn Gly Thr Asp Ser  Lys Thr Ile Arg Gln  Leu Val Trp 
    1790                 1795                 1800             


Asp Ala  Met Gln Ser Gly Val  Arg Tyr Ala Val Glu  Glu Lys Asn 
    1805                 1810                 1815             


Glu Asn  Phe Pro Pro Cys Met  Gly Val Glu His Ile  Gly Ile Ala 
    1820                 1825                 1830             


Lys Pro  Gln Phe Ile Arg Trp  Leu Glu Glu Trp Thr  Asn Glu Phe 
    1835                 1840                 1845             


Cys Glu  Lys Tyr Thr Lys Tyr  Phe Glu Asp Met Lys  Ser Lys Cys 
    1850                 1855                 1860             


Asp Pro  Pro Lys Ser Ala Asp  Asp Cys Gly Asp Asn  Ser Asn Ile 
    1865                 1870                 1875             


Glu Cys  Lys Arg Ala Cys Ala  Asn Tyr Thr Asn Trp  Leu Asn Pro 
    1880                 1885                 1890             


Lys Arg  Ile Glu Trp Asn Gly  Met Ser Asn Tyr Tyr  Asn Lys Ile 
    1895                 1900                 1905             


Tyr Arg  Lys Ser Asn Lys Glu  Ser Glu Asp Gly Lys  Asp Tyr Ser 
    1910                 1915                 1920             


Met Ile  Met Glu Pro Thr Val  Ile Asp Tyr Leu Asn  Lys Arg Cys 
    1925                 1930                 1935             


Asn Gly  Glu Ile Asn Gly Asn  Tyr Ile Cys Cys Ser  Cys Lys Asn 
    1940                 1945                 1950             


Ile Gly  Glu Asn Ser Thr Ser  Pro Ala Gln Lys Thr  Lys Gly Ser 
    1955                 1960                 1965             


Lys Lys  Lys Asp Glu Gln Cys  Glu Asp Asn Lys Gly  Pro Leu Asp 
    1970                 1975                 1980             


Leu Met  Asn Glu Val Leu Asn  Lys Met Asp Glu Lys  Tyr Ser Glu 
    1985                 1990                 1995             


His 
    


<210>  29
<211>  1966
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29

Met Asp Ser Thr Ser Thr Ile Gly Asp Lys Ile Glu Glu Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asn Glu Ser Asn Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Lys Val Gln Tyr Tyr Arg Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn 
    50                  55                  60                  


Asp Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Asn Asn Lys Asn Ile 
                85                  90                  95      


Phe Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Asn 
            100                 105                 110         


Leu Lys Phe Glu Arg Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Lys Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Lys Lys Ile Leu Glu 
            180                 185                 190         


Lys Asp Ser Thr Leu Lys Asn Asn Tyr Ser Asn Asp Asp Glu Asn Tyr 
        195                 200                 205             


Lys Lys Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys Val Trp 
    210                 215                 220                 


Glu Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg 
225                 230                 235                 240 


Arg Trp Thr Thr Ser Lys Glu Ser Asn Gly Glu Asn Lys Leu Glu Leu 
                245                 250                 255     


Cys Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp 
            260                 265                 270         


Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Leu 
        275                 280                 285             


Tyr Arg Glu Glu Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu 
    290                 295                 300                 


Glu Cys Thr Ser Glu Asp Asp Lys Ser Asn Glu Gly Thr Ser Tyr Cys 
305                 310                 315                 320 


Thr Asn Cys Lys Glu Lys His Thr Lys Tyr Cys Glu Cys Val Lys Lys 
                325                 330                 335     


Trp Lys Thr Glu Trp Glu Asn Gln Lys Asn Lys Tyr Asn Asp Leu Tyr 
            340                 345                 350         


Gln Gln Lys Lys Asn Glu Thr Ser Ser Ser Ser Lys Lys Lys Ser Arg 
        355                 360                 365             


Tyr Asp Asp Tyr Val Lys Asp Phe Phe Lys Lys Leu Lys Gly Asn Val 
    370                 375                 380                 


Tyr Ser Ser Ala Asn Ser Tyr Val Lys Asn Asp Pro Tyr Ser Lys Glu 
385                 390                 395                 400 


Tyr Val Thr Lys Leu Ser Phe Ile Leu Asn Pro Ser Asp Ala Asn Thr 
                405                 410                 415     


Ser Ser Gly Glu Thr Ala Asn His Asn Asp Glu Val Cys Asn Cys Asn 
            420                 425                 430         


Glu Ser Gly Ile Ala Cys Val Gly Gln Ala Gln Ile Ser Asp Arg Leu 
        435                 440                 445             


Ser Gln Lys Ala Cys Asn Thr His Ser Ser Ile Lys Thr Asn Lys Lys 
    450                 455                 460                 


Lys Glu Cys Lys His Val Lys Leu Gly Val Arg Glu Asn Asp Lys Val 
465                 470                 475                 480 


Leu Lys Ile Cys Val Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn 
                485                 490                 495     


Cys Cys Cys Gln Asp Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp 
            500                 505                 510         


Asn Ile Arg Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln 
        515                 520                 525             


Asp Glu Cys Glu Lys Asn Leu Asp Glu Ala Leu Ala Ser Leu Thr Asn 
    530                 535                 540                 


Cys Tyr Lys Cys Glu Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn 
545                 550                 555                 560 


Lys Asn Trp Ile Trp Lys Lys Tyr Ser Val Lys Glu Glu Gly Leu Gln 
                565                 570                 575     


Lys Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu 
            580                 585                 590         


Tyr Leu Gly Asn Leu Arg Lys Leu Glu Asn Val Cys Lys Asp Val Thr 
        595                 600                 605             


Asp Ile Asn Phe Asp Thr Lys Glu Lys Phe Leu Ala Gly Cys Leu Ile 
    610                 615                 620                 


Ala Ala Phe His Glu Gly Lys Asn Leu Lys Thr Thr Tyr Leu Glu Lys 
625                 630                 635                 640 


Lys Asn Asp Asp Asn Gly Lys Lys Leu Cys Lys Ala Leu Lys Tyr Ser 
                645                 650                 655     


Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn 
            660                 665                 670         


Asp Phe Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ala Phe Gly Lys 
        675                 680                 685             


Leu Phe Arg Lys Tyr Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr 
    690                 695                 700                 


Ser Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn 
705                 710                 715                 720 


Lys Lys Tyr Ile Trp Thr Ala Met Lys His Gly Thr Thr Cys Ser Ser 
                725                 730                 735     


Gly Ser Gly Asp Asn Gly Ser Ile Ser Cys Asp Asp Met Pro Thr Ile 
            740                 745                 750         


Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His 
        755                 760                 765             


Phe Cys Lys Gln Arg Gln Glu Lys Val Asn Ala Val Ile Thr Asn Cys 
    770                 775                 780                 


Lys Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr 
785                 790                 795                 800 


Glu Cys Glu Lys Lys Cys Lys Thr Lys Cys Lys Asp Glu Cys Asp Ala 
                805                 810                 815     


Tyr Lys Asn Phe Ile Glu Asn Cys Lys Gly Gly Asp Gly Thr Ala Gly 
            820                 825                 830         


Ser Pro Trp Ser Lys Arg Trp Asp Gln Ile Tyr Met Arg Tyr Ser Lys 
        835                 840                 845             


Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys 
    850                 855                 860                 


Gly Thr Ser Ala Ala Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser 
865                 870                 875                 880 


Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr 
                885                 890                 895     


Leu Ser Ile Val Leu Asp Glu Asn Ile Cys Gly Asp Asp Asn Ala Pro 
            900                 905                 910         


Trp Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys 
        915                 920                 925             


Ser Lys Ser Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser 
    930                 935                 940                 


Pro Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Val Cys Glu Cys Arg 
945                 950                 955                 960 


Thr Pro Ser Asn Glu Glu Thr Cys Asp Asp Arg Lys Glu Tyr Met Asn 
                965                 970                 975     


Gln Trp Ile Ser Asp Thr Ser Lys Asn Pro Lys Gly Ser Gly Ser Gly 
            980                 985                 990         


Lys Asp Tyr Tyr Glu Leu Cys Lys  Tyr Asn Gly Val Lys  Glu Thr Lys 
        995                 1000                 1005             


Leu Pro  Lys Lys Ser Ser Ser  Thr Lys Leu Asp Glu  Asn Asp Val 
    1010                 1015                 1020             


Met Phe  Phe Asn Leu Phe Glu  Gln Trp Asn Lys Glu  Ile Gln Tyr 
    1025                 1030                 1035             


Gln Ile  Glu Gln Tyr Met Thr  Asn Thr Lys Ile Ser  Cys Asn Asn 
    1040                 1045                 1050             


Glu Met  Lys Val Leu Ser Arg  Val Ser Glu Glu Ser  Lys Asn Gln 
    1055                 1060                 1065             


Asn Ser  Ser Asp Asn His Asp  Gly Gly Asn Asn Asn  Thr Asp Gln 
    1070                 1075                 1080             


Gly Thr  Asn Cys Lys Glu Lys  Cys Glu Cys Tyr Glu  Leu Trp Ile 
    1085                 1090                 1095             


Glu Lys  Ile Lys Lys Gln Trp  Glu Thr Gln Lys Lys  Asn Tyr Asn 
    1100                 1105                 1110             


Asn Phe  Glu Thr Lys Gln Ser  Asn Asp Ala Arg Lys  Ser Ser Gln 
    1115                 1120                 1125             


Asn Lys  Lys Glu Ile Val Lys  Leu Ser His Phe Leu  Phe Phe Ser 
    1130                 1135                 1140             


Cys Trp  Glu Glu Tyr Ile Gln  Lys Tyr Phe Asn Gly  Asp Trp Ser 
    1145                 1150                 1155             


Lys Ile  Lys Asn Ile Gly Ser  Asp Thr Phe Glu Phe  Leu Ile Lys 
    1160                 1165                 1170             


Lys Cys  Gly Asn Asn Ser Gly  Asp Gly Glu Thr Ile  Phe Ser Glu 
    1175                 1180                 1185             


Lys Leu  Asn Asn Ala Gln Gln  Gln Cys Lys Glu Ile  Gln Asn Thr 
    1190                 1195                 1200             


Asp Thr  Lys Ile Asn Lys Ser  Glu Thr Ser Ser Val  Leu Asn Ala 
    1205                 1210                 1215             


Thr Asn  Tyr Ile Arg Gly Cys  Gln Ser Lys Thr Tyr  Asp Gly Lys 
    1220                 1225                 1230             


Ile Phe  Pro Gly Lys Gly Gly  Glu Lys Gln Trp Ile  Cys Lys Asp 
    1235                 1240                 1245             


Thr Ile  Ile His Gly Asp Thr  Asn Gly Ala Cys Ile  Pro Pro Arg 
    1250                 1255                 1260             


Thr Gln  Asn Leu Cys Val Gly  Glu Leu Trp Asp Lys  Arg Tyr Gly 
    1265                 1270                 1275             


Gly Arg  Ser Asn Ile Lys Asn  Asp Thr Lys Glu Ser  Leu Lys Gln 
    1280                 1285                 1290             


Lys Ile  Lys Asn Ala Ile Gln  Lys Glu Thr Glu Leu  Leu Tyr Glu 
    1295                 1300                 1305             


Tyr His  Asp Lys Gly Thr Ala  Ile Ile Ser Arg Asn  Pro Met Lys 
    1310                 1315                 1320             


Gly Lys  Lys Ala Asn Asn Asn  Lys Asn Ser Asn Gly  Leu Pro Lys 
    1325                 1330                 1335             


Gly Phe  Cys His Ala Val Gln  Arg Ser Phe Ile Asp  Tyr Lys Asn 
    1340                 1345                 1350             


Met Ile  Leu Gly Thr Ser Val  Asn Ile Tyr Glu Tyr  Ile Gly Lys 
    1355                 1360                 1365             


Leu Gln  Glu Asp Ile Lys Lys  Ile Ile Glu Gln Glu  Thr Thr Lys 
    1370                 1375                 1380             


Gln Lys  Asp Lys Ile Gly Gly  Val Gly Ser Ser Ala  Asp Lys Val 
    1385                 1390                 1395             


Asn Asp  Trp Trp Lys Gly Ile  Glu Gly Glu Met Trp  Gly Ala Val 
    1400                 1405                 1410             


Lys Ser  Gly Ile Lys Thr Ile  Lys Lys Gln Asn Asn  Lys Cys Thr 
    1415                 1420                 1425             


Tyr Thr  Gly Asn Glu Cys Gly  Val Ser Pro Pro Thr  Gly Asn Asp 
    1430                 1435                 1440             


Glu Asp  Gln Ser Val Ser Trp  Phe Lys Glu Trp Gly  Glu Gln Phe 
    1445                 1450                 1455             


Cys Ile  Glu Arg Leu Gln Tyr  Glu Gln Asn Ile Arg  Asp Ala Cys 
    1460                 1465                 1470             


Thr Asn  Asn Gly Lys Asn Gly  Lys Lys Cys Ile Asn  Ser Lys Ser 
    1475                 1480                 1485             


Gly Gln  Glu Asp Lys Ile Gln  Gly Asp Cys Lys Arg  Lys Cys Glu 
    1490                 1495                 1500             


Lys Tyr  Lys Lys Tyr Ile Ser  Glu Lys Lys Lys Glu  Trp Asp Lys 
    1505                 1510                 1515             


Gln Lys  Thr Lys Tyr Glu Asn  Lys Tyr Val Gly Lys  Ser Ala Ser 
    1520                 1525                 1530             


Asp Leu  Leu Lys Glu Asn Tyr  Pro Glu Cys Ile Ser  Ala Asn Phe 
    1535                 1540                 1545             


Asp Phe  Ile Phe Asn Asp Lys  Ala Asp His Lys Lys  Tyr Tyr Pro 
    1550                 1555                 1560             


Tyr Gly  Asp Tyr Asn Ser Ile  Cys Ser Cys Glu Gln  Val Lys Tyr 
    1565                 1570                 1575             


Tyr Lys  Tyr Asn Asn Ala Glu  Lys Lys Asn Asn Lys  Ser Leu Cys 
    1580                 1585                 1590             


His Glu  Lys Gly Asn Asp Arg  Thr Trp Ser Lys Lys  Tyr Ile Lys 
    1595                 1600                 1605             


Lys Leu  Glu Asn Gly Arg Thr  Leu Glu Gly Val Tyr  Val Pro Pro 
    1610                 1615                 1620             


Arg Arg  Gln Gln Leu Cys Leu  Tyr Glu Leu Phe Pro  Ile Ile Ile 
    1625                 1630                 1635             


Lys Lys  Glu Lys Asp Met Glu  Lys Ala Lys Glu Glu  Leu Leu Glu 
    1640                 1645                 1650             


Thr Leu  Gln Ile Val Ala Glu  Arg Glu Ala Tyr Tyr  Leu Trp Lys 
    1655                 1660                 1665             


Gln Tyr  Asn Pro Thr Gly Lys  Gly Ile Asp Asp Ala  Asn Lys Lys 
    1670                 1675                 1680             


Ala Cys  Cys Ala Ile Arg Gly  Ser Phe Tyr Asp Leu  Glu Asp Ile 
    1685                 1690                 1695             


Ile Lys  Gly Asn Asp Leu Val  His Asp Glu Tyr Thr  Lys Tyr Ile 
    1700                 1705                 1710             


Asp Ser  Lys Leu Asn Lys Ile  Phe Gly Ser Ser Asn  Thr Asn Asn 
    1715                 1720                 1725             


Ile Asp  Thr Lys Arg Ala Arg  Thr Asp Trp Trp Glu  Asn Lys Thr 
    1730                 1735                 1740             


Ile Asp  Val Pro Lys Ile Asp  Val Ala Asn Gly Thr  Asp Ser Lys 
    1745                 1750                 1755             


Thr Ile  Arg Gln Leu Val Trp  Asp Ala Met Gln Ser  Gly Val Arg 
    1760                 1765                 1770             


Tyr Ala  Val Glu Lys Asn Glu  Lys Lys Lys Gln Asn  Glu Asn Phe 
    1775                 1780                 1785             


Pro Pro  Cys Met Arg Val Gln  His Ile Gly Ile Ala  Lys Pro Gln 
    1790                 1795                 1800             


Phe Ile  Arg Trp Leu Glu Glu  Trp Thr Asn Glu Phe  Cys Glu Lys 
    1805                 1810                 1815             


Tyr Thr  Lys Tyr Phe Glu Asp  Met Lys Ser Asn Cys  Asp Pro Pro 
    1820                 1825                 1830             


Lys Gly  Ala Asp Asp Cys Gly  Asp Asn Ser Asn Ile  Glu Cys Lys 
    1835                 1840                 1845             


Lys Ala  Cys Ala Asn Tyr Thr  Asn Trp Leu Asn Pro  Lys Arg Ile 
    1850                 1855                 1860             


Glu Trp  Asn Gly Met Ser Asn  Tyr Tyr Asn Lys Ile  Tyr Arg Lys 
    1865                 1870                 1875             


Ser Asn  Lys Glu Ser Glu Asp  Gly Lys Asp Tyr Ser  Met Ile Met 
    1880                 1885                 1890             


Glu Pro  Thr Val Ile Asp Tyr  Leu Asn Lys Arg Cys  His Gly Glu 
    1895                 1900                 1905             


Ile Asn  Gly Asn Tyr Ile Cys  Cys Ser Cys Lys Asn  Ile Gly Glu 
    1910                 1915                 1920             


Asn Ser  Thr Ser Pro Ala Gln  Lys Thr Lys Gly Ser  Lys Lys Lys 
    1925                 1930                 1935             


Gly Glu  Gln Cys Glu Asp Asn  Lys Gly Pro Leu Asp  Leu Met Asn 
    1940                 1945                 1950             


Glu Val  Leu Asn Lys Met Asp  Glu Lys Tyr Ser Ala  His 
    1955                 1960                 1965     


<210>  30
<211>  1992
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30

Met Asp Ser Lys Thr Thr Ile Ala Glu Lys Ile Glu Ala Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asn Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn 
    50                  55                  60                  


Asp Pro Cys Asp Ser Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Lys Pro Glu Asn Val 
                85                  90                  95      


Phe Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Asn 
            100                 105                 110         


Leu Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Ile Leu Tyr His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Gln Asn Leu Arg Arg Met Phe Ala Lys Ile Arg Glu 
            180                 185                 190         


Asn Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Thr 
        195                 200                 205             


Lys Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly 
225                 230                 235                 240 


Trp Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Gln Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr 
        275                 280                 285             


Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Glu Tyr Asp Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser 
305                 310                 315                 320 


Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp 
                325                 330                 335     


Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Asn Asp Leu Tyr Gln 
            340                 345                 350         


Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asn 
        355                 360                 365             


Tyr Val Lys Glu Phe Phe Lys Asn Phe Lys Gly Asp Asn Tyr Lys Ser 
    370                 375                 380                 


Leu Glu Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Val Thr 
385                 390                 395                 400 


Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Thr Ser Ser Glu 
                405                 410                 415     


Lys Ile Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Glu 
            420                 425                 430         


Ile Ala Ser Val Gly Gln Ala Ser Ile Ser Asp Pro Ser Ser Asn Lys 
        435                 440                 445             


Thr Cys Asn Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys 
    450                 455                 460                 


Lys Asp Val Lys Leu Gly Val Arg Glu Lys Asp Lys Asp Leu Lys Ile 
465                 470                 475                 480 


Cys Val Ile Glu Asp Asp Ser Leu Arg Gly Val Asp Asn Cys Cys Cys 
                485                 490                 495     


Gln Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Asp Glu Cys 
        515                 520                 525             


Gln Lys Lys Leu Glu Asn Val Phe Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Cys Asp Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Asn Lys Trp 
545                 550                 555                 560 


Ile Trp Arg Lys Phe Pro Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr 
                565                 570                 575     


Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Leu Leu Tyr Leu Val 
            580                 585                 590         


Cys Leu His Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg 
        595                 600                 605             


Thr Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu 
    610                 615                 620                 


Gly Lys Asn Leu Lys Thr Thr Tyr Pro Gln Lys Lys Asn Asp Asp Asn 
625                 630                 635                 640 


Gly Lys Lys Leu Cys Lys Asp Leu Lys Tyr Ser Phe Ala Asp Tyr Gly 
                645                 650                 655     


Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Asp Phe Thr Lys Asp 
            660                 665                 670         


Leu Glu Leu Asn Leu Gln Gln Ile Phe Gly Lys Leu Phe Arg Lys Tyr 
        675                 680                 685             


Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp 
705                 710                 715                 720 


Thr Ala Met Lys His Gly Ala Gly Met Asn Ser Thr Met Cys Asn Ala 
                725                 730                 735     


Asp Gly Ser Val Thr Gly Ser Ser Asp Ser Gly Ser Thr Thr Cys Ser 
            740                 745                 750         


Gly Asp Asn Gly Ser Ile Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu 
        755                 760                 765             


Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe Cys 
    770                 775                 780                 


Glu Gln Arg Gln Ala Lys Val Asn Ala Val Ile Thr Asn Cys Lys Ser 
785                 790                 795                 800 


Cys Lys Glu Ser Gly Gly Thr Cys Asn Ser Asp Cys Lys Thr Glu Cys 
                805                 810                 815     


Lys Asn Lys Cys Lys Val Ala Cys Asp Ala Tyr Lys Thr Phe Ile Glu 
            820                 825                 830         


Asp Cys Lys Gly Gly Gly Thr Gly Thr Ala Gly Ser Ser Trp Val Lys 
        835                 840                 845             


Arg Trp Tyr Gln Ile Tyr Met Arg Tyr Ser Lys Tyr Ile Glu Asp Ala 
    850                 855                 860                 


Lys Arg Asn Arg Lys Ala Gly Thr Lys Ser Cys Gly Thr Ser Ser Gly 
865                 870                 875                 880 


Ala Asn Ser Gly Val Thr Thr Ala Glu Asn Lys Cys Val Gln Ser Asp 
                885                 890                 895     


Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro 
            900                 905                 910         


Ser Ser Tyr Leu Ser Asn Val Leu Asp Glu Asn Asn Cys Gly Glu Asp 
        915                 920                 925             


Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Tyr Thr Thr Tyr 
    930                 935                 940                 


Thr Thr Thr Lys Asn Cys Asp Lys Asp Lys Lys Lys Ser Lys Ser Gln 
945                 950                 955                 960 


Ser Cys Asp Thr Leu Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
                965                 970                 975     


Thr Pro His Gly Tyr Lys Tyr Ala Cys Glu Cys Lys Ile Pro Thr Thr 
            980                 985                 990         


Glu Glu Thr Cys Asp Asp Arg Lys  Glu Tyr Met Asn Gln  Trp Ile Ile 
        995                 1000                 1005             


Asp Thr  Ser Lys Lys Gln Lys  Gly Ser Gly Ser Thr  Asn Asn Asp 
    1010                 1015                 1020             


Tyr Glu  Leu Tyr Thr Tyr Asn  Gly Val Lys Glu Thr  Lys Pro Leu 
    1025                 1030                 1035             


Gly Thr  Leu Asn Ser Ser Lys  Leu Asp Asp Lys Asp  Val Met Phe 
    1040                 1045                 1050             


Phe Asn  Leu Phe Glu Gln Trp  Asn Lys Glu Ile Gln  Tyr Gln Ile 
    1055                 1060                 1065             


Glu Gln  Tyr Met Thr Asn Thr  Lys Ile Ser Cys Asn  Asn Glu Met 
    1070                 1075                 1080             


Lys Val  Leu Ser Ser Ser Ser  Glu Glu Ser Gln Asn  Arg Asn Gly 
    1085                 1090                 1095             


Ser Asp  His His Asp Gly Arg  Asn Asn Asn Ile Asn  Gln Gly Thr 
    1100                 1105                 1110             


Asn Cys  Lys Glu Lys Cys Lys  Cys Tyr Glu Leu Trp  Ile Lys Lys 
    1115                 1120                 1125             


Ile Lys  Glu Gln Trp Asp Lys  Gln Lys Asn Asn Tyr  Asn Lys Phe 
    1130                 1135                 1140             


Gln Arg  Lys Gln Ile Tyr Asp  Ala Asn Lys Gly Pro  Gln Asn Lys 
    1145                 1150                 1155             


Lys Val  Val Ser Leu Ser His  Phe Leu Phe Phe Ser  Cys Trp Glu 
    1160                 1165                 1170             


Glu Tyr  Ile Gln Lys Tyr Phe  Asn Gly Asp Trp Ser  Lys Ile Lys 
    1175                 1180                 1185             


Asn Ile  Gly Ser Asp Thr Phe  Glu Tyr Leu Ile Lys  Lys Cys Gly 
    1190                 1195                 1200             


Asn Asn  Ser Gly Asp Gly Glu  Thr Ile Phe Ser Glu  Lys Leu Lys 
    1205                 1210                 1215             


Asn Ala  Glu Lys Lys Cys Lys  Glu Asn Lys Ser Thr  Asn Asn Lys 
    1220                 1225                 1230             


Met Lys  Ser Ser Gly Lys Ser  Ser Asp Cys Ser Glu  Thr Asn Tyr 
    1235                 1240                 1245             


Ile Arg  Gly Cys Gln Ser Lys  Thr Tyr Asp Gly Lys  Ile Phe Pro 
    1250                 1255                 1260             


Gly Lys  Gly Gly Glu Lys Gln  Trp Ile Cys Lys Asp  Thr Ile Thr 
    1265                 1270                 1275             


His Gly  Asp Thr Asn Gly Ala  Cys Ile Pro Pro Arg  Thr Gln Asn 
    1280                 1285                 1290             


Leu Cys  Val Gly Glu Leu Trp  Tyr Lys Ser Tyr Gly  Gly Arg Ser 
    1295                 1300                 1305             


Asn Ile  Lys Asn Asp Thr Lys  Glu Ser Leu Lys Asn  Lys Leu Lys 
    1310                 1315                 1320             


Asn Ala  Ile Gln Lys Glu Thr  Glu Leu Leu Tyr Glu  Tyr His Asp 
    1325                 1330                 1335             


Lys Gly  Thr Ala Ile Ile Ser  Gln Asn Asp Lys Lys  Glu Lys Ala 
    1340                 1345                 1350             


Asn Asn  Asn Asp Ser Asn Gly  Leu Pro Lys Gly Phe  Cys His Ala 
    1355                 1360                 1365             


Val Gln  Arg Ser Phe Ile Asp  Tyr Lys Asn Met Ile  Leu Gly Thr 
    1370                 1375                 1380             


Ser Val  Asn Ile Tyr Glu Tyr  Ile Gly Lys Leu Gln  Glu Asp Ile 
    1385                 1390                 1395             


Lys Lys  Ile Ile Glu Lys Gly  Thr Thr Lys Gln Lys  Asp Lys Ile 
    1400                 1405                 1410             


Gly Gly  Ser Gly Ala Asp Lys  Val Asn Asp Trp Trp  Lys Gly Ile 
    1415                 1420                 1425             


Glu Gly  Glu Met Trp Asp Ala  Val Lys Cys Gly Ile  Thr Lys Ile 
    1430                 1435                 1440             


Asn Lys  Lys Gln Lys Lys Asn  Gly Thr Phe Asn Gly  Asp Glu Cys 
    1445                 1450                 1455             


Gly Val  Ser Pro Pro Thr Gly  Asn Asp Glu Asp Gln  Phe Val Ser 
    1460                 1465                 1470             


Trp Phe  Lys Glu Trp Gly Glu  Gln Phe Cys Ile Glu  Arg Leu Arg 
    1475                 1480                 1485             


Tyr Glu  Gln Asn Ile Arg Glu  Ala Cys Thr Ile Asn  Gly Lys Asn 
    1490                 1495                 1500             


Gly Lys  Lys Cys Ile Asn Ser  Lys Ser Gly Gln Gly  Asp Lys Val 
    1505                 1510                 1515             


Glu Gly  Ala Cys Lys Arg Lys  Cys Glu Lys Tyr Lys  Lys Tyr Ile 
    1520                 1525                 1530             


Ser Glu  Lys Lys Gln Glu Trp  Asp Lys Gln Lys Thr  Lys Tyr Glu 
    1535                 1540                 1545             


Asn Lys  Tyr Val Gly Lys Ser  Ala Ser Asp Leu Leu  Lys Glu Asn 
    1550                 1555                 1560             


Tyr Pro  Glu Cys Ile Ser Ala  Asn Phe Asp Phe Ile  Phe Asn Asp 
    1565                 1570                 1575             


Asn Ile  Glu Tyr Lys Thr Tyr  Tyr Pro Tyr Gly Asp  Tyr Ser Ser 
    1580                 1585                 1590             


Ile Cys  Ser Cys Glu Gln Val  Lys Tyr Tyr Glu Tyr  Asn Asn Ala 
    1595                 1600                 1605             


Glu Lys  Lys Asn Asn Lys Ser  Leu Cys His Glu Lys  Gly Asn Asp 
    1610                 1615                 1620             


Arg Thr  Trp Ser Lys Lys Tyr  Ile Lys Lys Leu Glu  Asn Gly Arg 
    1625                 1630                 1635             


Thr Leu  Glu Gly Val Tyr Val  Pro Pro Arg Arg Gln  Gln Leu Cys 
    1640                 1645                 1650             


Leu Tyr  Glu Leu Phe Pro Ile  Ile Ile Lys Lys Glu  Lys Asp Met 
    1655                 1660                 1665             


Glu Lys  Ala Lys Lys Glu Leu  Leu Glu Thr Leu Lys  Ile Val Ala 
    1670                 1675                 1680             


Glu Arg  Glu Ala Tyr Tyr Leu  Trp Lys Gln Tyr Asn  Pro Thr Gly 
    1685                 1690                 1695             


Lys Gly  Ile Asp Asp Ala Asn  Lys Lys Ala Cys Cys  Ala Ile Arg 
    1700                 1705                 1710             


Gly Ser  Phe Tyr Asp Leu Glu  Asp Ile Ile Lys Gly  Asn Asp Leu 
    1715                 1720                 1725             


Val His  Asp Glu Tyr Thr Lys  Tyr Ile Asp Ser Lys  Leu Asn Glu 
    1730                 1735                 1740             


Ile Phe  Gly Ser Ser Asn Lys  Asn Asp Ile Asp Thr  Lys Arg Ala 
    1745                 1750                 1755             


Arg Thr  Asp Trp Trp Glu Asn  Glu Thr Ile Asp Val  Pro Asn Ile 
    1760                 1765                 1770             


Thr Gly  Ala Asn Lys Ser Asp  Ser Lys Thr Ile Arg  Gln Leu Val 
    1775                 1780                 1785             


Trp Asp  Ala Met Gln Ser Gly  Val Arg Lys Ala Ile  Tyr Glu Glu 
    1790                 1795                 1800             


Lys Glu  Lys Lys Lys Gln Asn  Glu Asn Phe Pro Pro  Cys Met Arg 
    1805                 1810                 1815             


Val Glu  His Ile Gly Ile Ala  Lys Pro Gln Phe Ile  Arg Trp Leu 
    1820                 1825                 1830             


Glu Glu  Trp Thr Asn Glu Phe  Cys Glu Glu Tyr Thr  Lys Tyr Phe 
    1835                 1840                 1845             


Glu Asp  Met Lys Ser Lys Cys  Asp Pro Pro Lys Arg  Ala Asp Asp 
    1850                 1855                 1860             


Cys Gly  Asp Asn Thr Asn Ile  Glu Cys Lys Lys Ala  Cys Ala Asn 
    1865                 1870                 1875             


Tyr Thr  Asn Trp Leu Asn Pro  Lys Arg Ile Glu Trp  Asn Gly Met 
    1880                 1885                 1890             


Ser Asn  Tyr Tyr Asn Lys Ile  Tyr Arg Lys Ser Asn  Lys Glu Ser 
    1895                 1900                 1905             


Glu Asp  Gly Lys Asp Tyr Ser  Met Ile Met Glu Pro  Thr Val Ile 
    1910                 1915                 1920             


Asp Tyr  Leu Asn Lys Arg Cys  His Gly Glu Ile Asn  Gly Asn Tyr 
    1925                 1930                 1935             


Ile Cys  Cys Ser Cys Lys Asn  Ile Gly Glu Asn Tyr  Asn Pro Ser 
    1940                 1945                 1950             


Pro Ala  Gln Lys Thr Lys Gly  Ser Lys Lys Lys Asp  Glu Gln Cys 
    1955                 1960                 1965             


Glu Asp  Asn Lys Gly Pro Leu  Asp Leu Met Asn Glu  Val Leu Asn 
    1970                 1975                 1980             


Lys Met  Asp Glu Lys Tyr Ser  Ala His 
    1985                 1990         


<210>  31
<211>  1599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31

Met Asp Lys Ser Ser Ile Gly Asp Lys Ile Glu Glu Tyr Leu Lys Glu 
1               5                   10                  15      


Lys Ser Asp Asp Ser Lys Ile Asp Glu Leu Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Lys Asn 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr Glu 
    50                  55                  60                  


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Gln Gln Asn Leu Tyr Lys Ala Ser Glu Asn Asn Lys Asn Val Phe 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Asn Leu 
            100                 105                 110         


Asn Val Glu Arg Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Ile Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Ile Ala Asp Ile Ile Arg Gly Arg Asp Gly Asn Lys Cys Glu Thr Lys 
                165                 170                 175     


Ser Thr Asn Asn Val Glu Glu Leu Ile Lys Lys Phe Phe Glu Lys Asn 
            180                 185                 190         


Tyr Arg Glu Asn Lys Glu Tyr Lys Arg Lys Tyr Pro Asn Asp Asp Pro 
        195                 200                 205             


Lys Tyr Thr Lys Leu Arg Glu Asp Trp Trp Thr Lys Asn Arg Gln Lys 
    210                 215                 220                 


Val Trp Glu Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile 
225                 230                 235                 240 


Lys Arg Gly Trp Thr Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys Leu 
                245                 250                 255     


Glu Leu Cys Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys 
            260                 265                 270         


Leu Asp Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu 
        275                 280                 285             


Asp Leu Tyr Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His 
    290                 295                 300                 


Arg Glu Glu Cys Thr Ser Glu Asp His Lys Ser Lys Glu Gly Ala Ser 
305                 310                 315                 320 


Tyr Cys Asn Met Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val 
                325                 330                 335     


Lys Lys Trp Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Lys Asp 
            340                 345                 350         


Leu Tyr Gln Gln Glu Asn Glu Thr Ser Ser Ser Ser Lys Lys Lys Ser 
        355                 360                 365             


Arg Tyr Asp Asp Tyr Val Lys Glu Phe Phe Lys Lys Leu Asn Glu Ala 
    370                 375                 380                 


Asn Tyr Ser Ser Leu Glu Asn Tyr Ile Lys Asp Asp Pro Tyr Ser Lys 
385                 390                 395                 400 


Glu Tyr Val Thr Lys Leu Ser Phe Ile Pro Asn Ser Ser Asp Ala Asn 
                405                 410                 415     


Thr Ser Ser Glu Lys Ile Gln Lys Asn Asn Asp Glu Val Cys Asn Pro 
            420                 425                 430         


Asn Glu Ser Gly Ile Ser Ser Val Glu Gln Ala Gln Thr Ser Gly Pro 
        435                 440                 445             


Ser Ser Asn Lys Thr Cys Ile Thr His Ser Ser Ile Lys Ala Asn Lys 
    450                 455                 460                 


Lys Lys Glu Cys Lys Asp Val Lys Leu Gly Val Arg Glu Asn Asp Lys 
465                 470                 475                 480 


Asp Leu Lys Ile Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp 
                485                 490                 495     


Asn Cys Cys Cys Gln Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser 
            500                 505                 510         


Asp Asn Lys Arg Gly Ser Ser Ser Asn Asp Ser Cys Asp Asn Lys Asn 
        515                 520                 525             


Gln Asp Glu Cys Gln Lys Lys Leu Asp Glu Ala Leu Glu Ser Leu His 
    530                 535                 540                 


Asn Gly Tyr Lys Asn Gln Lys Cys Lys Ser Gly Thr Ser Thr Val Asn 
545                 550                 555                 560 


Lys Lys Trp Ile Trp Lys Lys Ser Ser Gly Asn Lys Glu Gly Leu Gln 
                565                 570                 575     


Lys Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu 
            580                 585                 590         


Tyr Leu Gly Asn Leu Pro Lys Leu Glu Asn Val Ser Lys Gly Val Thr 
        595                 600                 605             


Asp Ile Ile Tyr Asp Thr Lys Glu Lys Phe Leu Ala Gly Cys Leu Ile 
    610                 615                 620                 


Val Ser Phe His Glu Gly Lys Asn Leu Lys Thr Ser His Glu Lys Lys 
625                 630                 635                 640 


Asn Asp Asp Asn Gly Lys Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe 
                645                 650                 655     


Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu 
            660                 665                 670         


Tyr Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ala Phe Gly Lys Leu 
        675                 680                 685             


Phe Arg Lys Tyr Ile Lys Lys Asn Ile Ser Ala Glu Gln Asp Thr Ser 
    690                 695                 700                 


Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys 
705                 710                 715                 720 


Lys Tyr Ile Trp Ile Ala Met Lys His Gly Ala Gly Met Asn Gly Thr 
                725                 730                 735     


Thr Cys Cys Gly Asp Gly Ser Ser Gly Glu Asn Gln Thr Asn Ser Cys 
            740                 745                 750         


Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu 
        755                 760                 765             


Gln Glu Trp Val Glu His Phe Cys Glu Gln Arg Gln Ala Lys Val Lys 
    770                 775                 780                 


Asp Val Ile Thr Asn Cys Lys Ser Cys Lys Asn Thr Ser Gly Glu Arg 
785                 790                 795                 800 


Lys Ile Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Lys Cys Lys Asn 
                805                 810                 815     


Lys Cys Glu Ala Tyr Lys Thr Phe Ile Glu His Cys Lys Gly Gly Asp 
            820                 825                 830         


Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln Ile Tyr Lys 
        835                 840                 845             


Arg Tyr Ser Lys His Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly 
    850                 855                 860                 


Thr Lys Ser Cys Gly Thr Ser Thr Ala Glu Asn Lys Cys Val Gln Ser 
865                 870                 875                 880 


Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr 
                885                 890                 895     


Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp Glu Asn Asn Cys Gly Glu 
            900                 905                 910         


Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Thr Lys Asn Cys Asp Ile 
        915                 920                 925             


Gln Lys Asp Lys Ser Lys Ser Gln Ser Ser Asp Thr Leu Val Val Val 
    930                 935                 940                 


Asn Val Pro Ser Pro Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala 
945                 950                 955                 960 


Cys Gln Cys Lys Ile Pro Thr Thr Glu Glu Thr Cys Asp Asp Arg Lys 
                965                 970                 975     


Glu Tyr Met Asn Gln Trp Ser Cys Gly Ser Ala Arg Thr Met Lys Arg 
            980                 985                 990         


Gly Tyr Lys Asn Asp Asn Tyr Glu  Leu Cys Lys Tyr Asn  Gly Val Asp 
        995                 1000                 1005             


Val Lys  Pro Thr Thr Val Arg  Ser Ser Ser Thr Lys  Leu Asp Gly 
    1010                 1015                 1020             


Asn Asp  Val Met Phe Phe Asn  Leu Phe Glu Gln Trp  Asn Lys Glu 
    1025                 1030                 1035             


Ile Gln  Tyr Gln Ile Glu Gln  Tyr Met Thr Asn Ala  Asn Ile Ser 
    1040                 1045                 1050             


Cys Asn  Asn Glu Met Lys Val  Leu Ser Ser Ser Ser  Glu Glu Ser 
    1055                 1060                 1065             


Gln Asn  Gln Asn Gly Ser Asp  His His Asp Gly Arg  Asn Asn Asn 
    1070                 1075                 1080             


Thr Asp  Gln Ser Thr Asn Cys  Lys Glu Lys Cys Glu  Cys Tyr Lys 
    1085                 1090                 1095             


Leu Trp  Ile Glu Lys Ile Lys  Lys Gln Trp Gly Lys  Gln Lys Asn 
    1100                 1105                 1110             


Asn Tyr  Asn Lys Phe Arg Ser  Lys Gln Ile Tyr Asp  Ala Asn Lys 
    1115                 1120                 1125             


Gly Pro  Gln Asn Lys Lys Val  Val Ser Leu Ser His  Phe Leu Phe 
    1130                 1135                 1140             


Phe Ser  Cys Trp Glu Glu Tyr  Ile Gln Lys Gln Phe  Asn Gly Asp 
    1145                 1150                 1155             


Trp Ser  Lys Ile Lys Asn Ile  Gly Ser Asp Thr Phe  Glu Phe Leu 
    1160                 1165                 1170             


Ile Lys  Lys Cys Gly Asn Asn  Ser Gly Asp Gly Glu  Thr Ile Phe 
    1175                 1180                 1185             


Asn Lys  Lys Leu Lys Asn Ala  Glu Lys Lys Cys Lys  Glu Asn Glu 
    1190                 1195                 1200             


Ser Thr  Asp Thr Lys Met Lys  Ser Ser Glu Thr Ser  Gly Ser Gly 
    1205                 1210                 1215             


Ser Gly  Ala Glu Lys Lys Asn  Asn Lys Ser Leu Cys  His Glu Lys 
    1220                 1225                 1230             


Gly Asn  Asp Arg Thr Trp Ser  Lys Lys Tyr Ile Lys  Lys Leu Glu 
    1235                 1240                 1245             


Asn Gly  Arg Thr Leu Glu Gly  Val Tyr Val Pro Pro  Arg Arg Gln 
    1250                 1255                 1260             


Gln Leu  Cys Leu Tyr Glu Leu  Phe Pro Ile Ile Ile  Lys Asn Lys 
    1265                 1270                 1275             


Asn Asp  Ile Thr Asn Ala Lys  Glu Glu Leu Leu Glu  Thr Leu Gln 
    1280                 1285                 1290             


Ile Val  Ala Glu Arg Glu Ala  Tyr Tyr Leu Trp Lys  Gln Tyr Asn 
    1295                 1300                 1305             


Pro Thr  Gly Lys Gly Ile Asp  Asp Ala Asn Lys Lys  Ala Cys Cys 
    1310                 1315                 1320             


Ala Ile  Arg Gly Ser Phe Tyr  Asp Leu Glu Asp Ile  Ile Lys Gly 
    1325                 1330                 1335             


Asn Asp  Leu Val His Asp Glu  Tyr Thr Lys Tyr Ile  Asp Ser Lys 
    1340                 1345                 1350             


Leu Asn  Glu Ile Phe Gly Ser  Ser Asn Lys Asn Asp  Ile Glu Thr 
    1355                 1360                 1365             


Lys Arg  Ala Arg Thr Asp Trp  Trp Glu Asn Glu Thr  Ile Thr Asn 
    1370                 1375                 1380             


Gly Thr  Asp Arg Lys Thr Ile  Arg Gln Leu Val Trp  Asp Ala Met 
    1385                 1390                 1395             


Gln Ser  Gly Val Arg Lys Ala  Ile Asp Glu Glu Lys  Glu Lys Lys 
    1400                 1405                 1410             


Lys Pro  Asn Glu Asn Phe Pro  Pro Cys Met Gly Val  Glu His Ile 
    1415                 1420                 1425             


Gly Ile  Ala Lys Pro Gln Phe  Ile Arg Trp Leu Glu  Glu Trp Thr 
    1430                 1435                 1440             


Asn Glu  Phe Cys Glu Glu Tyr  Thr Lys Tyr Phe Glu  Asp Met Lys 
    1445                 1450                 1455             


Ser Asn  Cys Asn Arg Arg Lys  Gly Ala Asp Asp Cys  Gly Asp Asn 
    1460                 1465                 1470             


Thr Asn  Ile Glu Cys Lys Lys  Ala Cys Ala Asn Tyr  Thr Asn Trp 
    1475                 1480                 1485             


Leu Asn  Pro Lys Arg Ile Glu  Trp Asn Gly Met Ser  Asn Tyr Tyr 
    1490                 1495                 1500             


Asn Lys  Ile Tyr Arg Lys Ser  Asn Lys Glu Ser Glu  Asp Gly Lys 
    1505                 1510                 1515             


Asp Tyr  Ser Met Ile Met Glu  Pro Thr Val Ile Asp  Tyr Leu Asn 
    1520                 1525                 1530             


Lys Arg  Cys Asn Gly Glu Ile  Asn Gly Asn Tyr Ile  Cys Cys Ser 
    1535                 1540                 1545             


Cys Lys  Asn Ile Gly Ala Tyr  Asn Thr Thr Ser Gly  Thr Val Asn 
    1550                 1555                 1560             


Lys Lys  Leu Gln Lys Lys Glu  Thr Glu Cys Glu Asp  Asn Lys Gly 
    1565                 1570                 1575             


Pro Leu  Asp Leu Met Asn Glu  Val Leu Asn Lys Met  Asp Glu Lys 
    1580                 1585                 1590             


Tyr Ser  Lys Leu Asn Leu 
    1595                 


<210>  32
<211>  1606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32

Met Asp Ser Thr Ser Thr Ile Gly Asp Lys Ile Glu Ala Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asn Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Lys Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn 
    50                  55                  60                  


Asp Pro Cys Glu Lys Lys Glu Leu Ser Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Asn Asn Lys Asn Ile 
                85                  90                  95      


Phe Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Lys 
            100                 105                 110         


Leu Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Ile Leu Tyr His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Ile Ala Asp Ile Ile Arg Gly Thr Asp Gln Leu Lys Gly Ser Asn 
                165                 170                 175     


Ile Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Lys 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Pro Asn Asp Asp Glu Asn Tyr Lys 
        195                 200                 205             


Lys Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Arg 
225                 230                 235                 240 


Trp Thr Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys Leu Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Leu Tyr 
        275                 280                 285             


Arg Glu Glu Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Lys Asn Val Glu Ser Asn Glu Gly Ala Ser Tyr Cys Asn 
305                 310                 315                 320 


Met Cys Lys Glu Lys His Thr Lys Tyr Cys Glu Cys Val Lys Lys Trp 
                325                 330                 335     


Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Glu 
            340                 345                 350         


Gln Glu Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
        355                 360                 365             


Val Lys Asp Phe Phe Glu Lys Leu Lys Gly Asn Gly Tyr Ser Ser Ala 
    370                 375                 380                 


Asn Ser Tyr Val Lys Asp Asp Pro Tyr Ser Ala Glu Tyr Val Thr Lys 
385                 390                 395                 400 


Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Thr Ser Ser Glu Thr 
                405                 410                 415     


Pro Ser Lys Tyr Tyr Asp Glu Val Cys Asn Cys Asn Glu Ser Glu Ile 
            420                 425                 430         


Ser Ser Val Gly Gln Ala Gln Thr Ser Gly Pro Ser Ser Asn Lys Thr 
        435                 440                 445             


Cys Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Val Cys Lys 
    450                 455                 460                 


Asp Val Lys Leu Gly Ile Asn Asn Asn Asp Lys Val Leu Arg Val Cys 
465                 470                 475                 480 


Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys Gln 
                485                 490                 495     


Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Lys Asn Gln Ser 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Asp Glu Cys 
        515                 520                 525             


Gln Lys Lys Leu Glu Lys Val Phe Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Cys Asp Lys Cys Lys Ser Gly Thr Ser Arg Ser Lys Lys Lys Trp Ile 
545                 550                 555                 560 


Trp Arg Lys Ser Ser Gly Asn Glu Glu Gly Leu Gln Lys Glu Tyr Ala 
                565                 570                 575     


Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Tyr Leu Gly Asn 
            580                 585                 590         


Leu Pro Lys Leu Glu Asn Val Cys Lys Gly Val Thr Asp Ile Ile Tyr 
        595                 600                 605             


Asp Thr Lys Glu Lys Phe Leu Ser Gly Cys Leu Ile Ala Ala Phe His 
    610                 615                 620                 


Glu Gly Lys Asn Leu Lys Thr Ser His Glu Lys Lys Asn Asp Asp Asn 
625                 630                 635                 640 


Gly Lys Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly 
                645                 650                 655     


Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Asp Phe Thr Lys Asp 
            660                 665                 670         


Leu Glu Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr 
        675                 680                 685             


Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp 
705                 710                 715                 720 


Thr Ala Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Ser Gly 
                725                 730                 735     


Asp Gly Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Met Pro Thr 
            740                 745                 750         


Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu 
        755                 760                 765             


His Phe Cys Lys Gln Arg Gln Glu Lys Val Lys Asp Val Ile Thr Asn 
    770                 775                 780                 


Cys Asn Ser Cys Lys Glu Cys Gly Asp Thr Cys Asn Gly Glu Cys Lys 
785                 790                 795                 800 


Thr Glu Cys Lys Thr Lys Cys Lys Gly Glu Cys Glu Lys Tyr Lys Asn 
                805                 810                 815     


Phe Ile Glu Glu Cys Asn Gly Thr Ala Asp Gly Gly Thr Ser Gly Ser 
            820                 825                 830         


Ser Trp Ser Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys Tyr 
        835                 840                 845             


Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly 
    850                 855                 860                 


Thr Ser Ser Thr Thr Asn Ala Ala Ala Ser Thr Thr Glu Asn Lys Cys 
865                 870                 875                 880 


Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly 
                885                 890                 895     


Leu Thr Thr Pro Ser Ser Tyr Leu Ser Asn Val Leu Asp Asp Asn Ile 
            900                 905                 910         


Cys Gly Glu Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr 
        915                 920                 925             


Lys Asn Cys Asp Ile Gln Lys Lys Thr Pro Lys Pro Gln Ser Cys Asp 
    930                 935                 940                 


Thr Leu Val Val Val Asn Val Pro Ser Pro Leu Gly Asn Thr Pro His 
945                 950                 955                 960 


Gly Tyr Lys Tyr Val Cys Glu Cys Lys Ile Pro Thr Thr Glu Glu Thr 
                965                 970                 975     


Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp Ile Ile Asp Thr Ser 
            980                 985                 990         


Lys Lys Gln Lys Gly Ser Gly Ser  Thr Asn Asn Asp Tyr  Glu Leu Tyr 
        995                 1000                 1005             


Thr Tyr  Asn Gly Val Gln Ile  Lys Gln Ala Ala Gly  Thr Leu Lys 
    1010                 1015                 1020             


Asn Ser  Lys Leu Asp Glu Asn  Asp Val Met Phe Phe  Asn Leu Phe 
    1025                 1030                 1035             


Glu Gln  Trp Asn Lys Glu Ile  Gln Tyr Gln Ile Glu  Gln Tyr Met 
    1040                 1045                 1050             


Thr Asn  Thr Lys Ile Ser Cys  Asn Asn Glu Lys Asn  Val Leu Ser 
    1055                 1060                 1065             


Arg Val  Ser Glu Glu Ser Gln  Asn Gln Asn Gly Ser  Asp His His 
    1070                 1075                 1080             


Asp Gly  Gly Asn Asn Asn Thr  Asp Gln Gly Thr Asn  Cys Lys Lys 
    1085                 1090                 1095             


Asn Cys  Glu Cys Tyr Glu Leu  Trp Ile Lys Lys Ile  Thr Glu Gln 
    1100                 1105                 1110             


Trp Glu  Thr Gln Lys Lys Asn  Tyr Asn Lys Phe Gln  Ser Lys Gln 
    1115                 1120                 1125             


Ile Tyr  Asp Gly Asn Asn Ala  Ser His Lys Lys Glu  Ile Val Lys 
    1130                 1135                 1140             


Leu Ser  His Phe Leu Phe Phe  Ser Cys Trp Glu Glu  Tyr Ile Gln 
    1145                 1150                 1155             


Lys Tyr  Phe Asn Gly Asp Trp  Ser Lys Ile Lys Asn  Ile Gly Ser 
    1160                 1165                 1170             


Asp Thr  Phe Glu Phe Leu Ile  Lys Lys Cys Gly Asn  Asn Ser Gly 
    1175                 1180                 1185             


Asp Gly  Glu Thr Ile Phe Ser  Glu Lys Leu Lys Asn  Ala Gln Gln 
    1190                 1195                 1200             


Gln Cys  Lys Glu Ile Gln Asn  Thr Asp Thr Lys Ile  Asn Pro Ser 
    1205                 1210                 1215             


Val Ile  Ser Gly Ser Gly Ser  Gly Ala Glu Lys Lys  Asn Asn Lys 
    1220                 1225                 1230             


Ser Leu  Cys His Glu Lys Gly  Asn Asp Arg Thr Trp  Ser Lys Lys 
    1235                 1240                 1245             


Tyr Ile  Lys Lys Leu Glu Asn  Gly Arg Ser Leu Glu  Gly Val Tyr 
    1250                 1255                 1260             


Val Pro  Pro Arg Arg Gln Gln  Leu Cys Leu Tyr Glu  Leu Phe Pro 
    1265                 1270                 1275             


Ile Ile  Ile Lys Asn Glu Glu  Gly Met Glu Lys Ala  Lys Glu Glu 
    1280                 1285                 1290             


Leu Leu  Glu Thr Leu Gln Ile  Val Ala Glu Arg Glu  Ala Tyr Tyr 
    1295                 1300                 1305             


Leu Trp  Lys Gln Tyr Asn Pro  Thr Gly Lys Gly Ile  Asp Asp Ala 
    1310                 1315                 1320             


Asn Lys  Lys Ala Cys Cys Ala  Ile Arg Gly Ser Phe  Tyr Asp Leu 
    1325                 1330                 1335             


Glu Asp  Ile Ile Lys Gly Asn  Asp Leu Val His Asp  Glu Tyr Thr 
    1340                 1345                 1350             


Lys Tyr  Ile Asp Ser Lys Leu  Asn Glu Ile Phe Gly  Ser Ser Asn 
    1355                 1360                 1365             


Lys Asn  Asp Ile Asp Thr Lys  Arg Ala Arg Thr Asp  Trp Trp Glu 
    1370                 1375                 1380             


Asn Glu  Thr Ile Asp Val Ala  Asn Gly Thr Asp His  Lys Thr Ile 
    1385                 1390                 1395             


Arg Gln  Leu Val Trp Asp Ala  Met Gln Ser Gly Val  Arg Lys Ala 
    1400                 1405                 1410             


Ile Asp  Glu Glu Asn Glu Lys  Lys Lys Gln Asn Lys  Asn Phe Pro 
    1415                 1420                 1425             


Pro Cys  Met Gly Val Glu His  Ile Gly Ile Ala Lys  Pro Gln Phe 
    1430                 1435                 1440             


Ile Arg  Trp Leu Glu Glu Trp  Thr Asn Glu Phe Cys  Glu Glu Tyr 
    1445                 1450                 1455             


Thr Lys  Tyr Phe Gly Ala Ile  Asn Ser Asn Cys Asn  Arg Arg Lys 
    1460                 1465                 1470             


Gly Ala  Asp Asp Cys Gly Asp  Asn Ser Asn Ile Glu  Cys Lys Arg 
    1475                 1480                 1485             


Ala Cys  Ala Asn Tyr Thr Asn  Trp Leu Asn Pro Lys  Arg Ile Glu 
    1490                 1495                 1500             


Trp Asn  Gly Met Ser Asn Tyr  Tyr Asn Lys Ile Tyr  Arg Lys Ser 
    1505                 1510                 1515             


Asn Lys  Glu Ser Glu Asp Gly  Lys Asp Tyr Ser Met  Ile Met Ala 
    1520                 1525                 1530             


Pro Thr  Val Ile Asp Tyr Leu  Asn Lys Arg Cys Asn  Gly Glu Ile 
    1535                 1540                 1545             


Asn Gly  Asn Tyr Ile Cys Cys  Ser Cys Lys Asn Ile  Gly Glu Asn 
    1550                 1555                 1560             


Tyr Asn  Pro Ser Pro Ala Gln  Lys Thr Lys Gly Ser  Lys Lys Lys 
    1565                 1570                 1575             


Asp Glu  Gln Cys Glu Asp Asn  Lys Gly Pro Leu Asp  Leu Met Asn 
    1580                 1585                 1590             


Glu Val  Leu Asn Lys Met Asp  Glu Lys Tyr Ser Ala  His 
    1595                 1600                 1605     


<210>  33
<211>  1606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  33

Met Asp Ser Thr Ser Thr Ile Gly Asp Lys Ile Glu Glu Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asn Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Lys Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Glu Pro Cys Asp Ser Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Asp Glu Asn Leu Phe Lys Ala Ser Gly Asn His Lys Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Gln His Met Cys Ile Lys Asn Leu Glu Asn 
            100                 105                 110         


Leu Lys Phe Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Ile Leu Tyr His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Ile Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Lys Phe Glu Pro Tyr Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Lys 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Gln Asn Asp Asp Glu Asn Tyr Lys 
        195                 200                 205             


Lys Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Arg 
225                 230                 235                 240 


Trp Arg Thr Ser Gly Lys Ser Asn Gly Glu Asn Lys Leu Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Tyr Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Leu Tyr 
        275                 280                 285             


Arg Glu Glu Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Lys Asn Val Asp Ser Lys Glu Gly Thr Ser Tyr Cys Asn 
305                 310                 315                 320 


Met Cys Lys Glu Lys His Thr Lys Tyr Cys Glu Phe Val Asn Lys Trp 
                325                 330                 335     


Lys Ser Glu Trp Lys Asn Gln Glu Asn Lys Tyr Lys Asp Leu Tyr Gln 
            340                 345                 350         


Gln Glu Asn Lys Thr Ser Ser Ser Ser Lys Asn Thr Ser Arg Tyr Asp 
        355                 360                 365             


Asn Tyr Val Lys Glu Phe Phe Glu Lys Leu Glu Ala Asn Tyr Lys Ser 
    370                 375                 380                 


Leu Glu Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Val Thr 
385                 390                 395                 400 


Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Thr Ser Ser Gly 
                405                 410                 415     


Glu Thr Ala Asn His Asn Asp Glu Ala Cys Asn Arg Asn Glu Ser Glu 
            420                 425                 430         


Ile Ser Ser Val Glu Gln Ala Pro Ile Ser Gly Pro Ser Ser Asn Lys 
        435                 440                 445             


Thr Cys Asn Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Glu Cys 
    450                 455                 460                 


Lys Asp Val Lys Leu Gly Ile Asn Asn Asn Asp Lys Asp Leu Lys Ile 
465                 470                 475                 480 


Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys 
                485                 490                 495     


Gln Asp Phe Leu Arg Met Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asp Asn Lys Asn Gln Asp Glu Cys 
        515                 520                 525             


Gln Thr Lys Leu Asp Glu Ala Leu Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Cys Glu Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Asn Gln Trp 
545                 550                 555                 560 


Ile Trp Lys Lys Ser Arg Gly Thr Glu Gly Gly Leu Gln Glu Glu Tyr 
                565                 570                 575     


Ala Asn Thr Ile Ala Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val 
            580                 585                 590         


Cys Leu His Glu Lys Glu Glu Lys Thr Gln His Lys Thr Ile Ser Thr 
        595                 600                 605             


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
    610                 615                 620                 


Lys Asn Leu Lys Lys Arg Tyr His Gln Asn Lys Asn Ala Asp Asn Glu 
625                 630                 635                 640 


Lys Lys Lys Gly Glu Asn Lys Lys Lys Leu Cys Lys Ala Leu Lys Tyr 
                645                 650                 655     


Ser Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp 
            660                 665                 670         


Asn Glu Tyr Thr Lys Asp Leu Glu Leu Asn Leu Gln Gln Ile Phe Gly 
        675                 680                 685             


Lys Leu Phe Arg Lys Tyr Ile Lys Lys Asn Ile Ser Thr Glu Gln Asp 
    690                 695                 700                 


Thr Leu Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr 
705                 710                 715                 720 


Asn Lys Lys Tyr Ile Trp Leu Ala Met Lys His Gly Ala Glu Met Asn 
                725                 730                 735     


Gly Thr Thr Cys Cys Gly Asp Gly Ser Ser Gly Glu Asn Gln Thr Asn 
            740                 745                 750         


Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg 
        755                 760                 765             


Phe Leu Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg Gln Glu Asn 
    770                 775                 780                 


Val Asn Ala Val Ile Glu Asn Cys Lys Ser Cys Lys Glu Cys Gly Gly 
785                 790                 795                 800 


Thr Cys Gly Ser Asp Cys Lys Thr Glu Cys Glu Lys Lys Cys Lys Ala 
                805                 810                 815     


Tyr Lys Glu Phe Ile Glu Lys Cys Glu Gly Gln Ala Ala Glu Gly Thr 
            820                 825                 830         


Ser Gly Tyr Ser Trp Ser Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr 
        835                 840                 845             


Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys 
    850                 855                 860                 


Asn Cys Gly Thr Ser Ser Gly Ala Thr Ser Gly Val Thr Thr Thr Glu 
865                 870                 875                 880 


Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile 
                885                 890                 895     


Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp 
            900                 905                 910         


Asp Asn Ile Cys Gly Ala Asp Asn Ala Pro Trp Thr Thr Tyr Thr Thr 
        915                 920                 925             


Tyr Thr Thr Lys Asn Cys Asp Lys Glu Lys Asp Lys Ser Lys Ser Gln 
    930                 935                 940                 


Ser Cys Asp Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
945                 950                 955                 960 


Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro Thr Thr 
                965                 970                 975     


Glu Glu Ser Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp Ile Ile 
            980                 985                 990         


Asp Asn Thr Lys Asn Pro Lys Gly  Ser Arg Ser Thr Asn  Asn Asp Tyr 
        995                 1000                 1005             


Glu Leu  Tyr Thr Tyr Asn Gly  Val Lys Glu Thr Lys  Leu Pro Lys 
    1010                 1015                 1020             


Lys Leu  Asn Ser Ser Lys Leu  Asp Glu Asn Asp Val  Thr Phe Phe 
    1025                 1030                 1035             


Asn Leu  Phe Glu Gln Trp Asn  Lys Glu Ile Gln Tyr  Gln Ile Glu 
    1040                 1045                 1050             


Gln Tyr  Met Thr Asn Thr Lys  Ile Ser Cys Asn Asn  Glu Lys Asn 
    1055                 1060                 1065             


Val Leu  Ser Ser Ser Ser Glu  Glu Ser Lys Asn Gln  Asn Gly Ser 
    1070                 1075                 1080             


Asp His  His Asp Gly Gly Asn  Asn Asn Ile Asn Gln  Gly Thr Asn 
    1085                 1090                 1095             


Cys Lys  Glu Lys Cys Glu Cys  Tyr Glu Leu Trp Ile  Lys Lys Ile 
    1100                 1105                 1110             


Lys Glu  Gln Trp Asp Lys Gln  Lys Asn Asn Tyr Asn  Lys Phe Gln 
    1115                 1120                 1125             


Ser Lys  Gln Ile Tyr Asp Ala  Arg Lys Ser Ser Gln  Asn Lys Lys 
    1130                 1135                 1140             


Glu Ile  Val Lys Leu Ser His  Phe Leu Phe Phe Ser  Cys Trp Glu 
    1145                 1150                 1155             


Glu Tyr  Ile Gln Lys Tyr Phe  Asn Gly Asp Trp Ser  Lys Ile Lys 
    1160                 1165                 1170             


Asn Ile  Gly Ser Asp Thr Phe  Glu Phe Leu Ile Lys  Lys Cys Gly 
    1175                 1180                 1185             


Asn Asn  Ser Gly Asp Gly Glu  Thr Ile Phe Ser Glu  Lys Leu Lys 
    1190                 1195                 1200             


Asn Ala  His Ile Lys Cys Lys  Glu Asn Glu Ser Thr  Asp Thr Lys 
    1205                 1210                 1215             


Ile Asn  Lys Ser Glu Thr Ser  Ser Lys Gly Ser Gly  Ser Gly Ala 
    1220                 1225                 1230             


Glu Lys  Lys Asn Asn Lys Ser  Leu Cys His Glu Lys  Gly Asn Asp 
    1235                 1240                 1245             


Arg Thr  Trp Ser Lys Lys Tyr  Ile Lys Lys Leu Glu  Asn Gly Arg 
    1250                 1255                 1260             


Thr Leu  Glu Gly Val Tyr Val  Pro Pro Arg Arg Gln  Gln Leu Cys 
    1265                 1270                 1275             


Leu Tyr  Glu Leu Phe Pro Ile  Ile Ile Lys Lys Glu  Lys Asp Met 
    1280                 1285                 1290             


Glu Lys  Ala Lys Glu Leu Leu  Glu Thr Leu Gln Ile  Val Ala Glu 
    1295                 1300                 1305             


Arg Glu  Ala Tyr Tyr Leu Trp  Lys Gln Tyr Asn Pro  Thr Gly Lys 
    1310                 1315                 1320             


Gly Ile  Asp Asp Ala Asn Lys  Lys Ala His Lys Lys  Ala Cys Cys 
    1325                 1330                 1335             


Ala Ile  Arg Gly Ser Phe Tyr  Asp Leu Glu Asp Ile  Ile Lys Gly 
    1340                 1345                 1350             


Asn Asp  Leu Val His Asp Glu  Tyr Thr Lys Tyr Ile  Asp Ser Lys 
    1355                 1360                 1365             


Leu Asn  Glu Ile Phe Gly Ser  Ser Asn Thr Asn Asp  Ile Glu Thr 
    1370                 1375                 1380             


Lys Arg  Ala Arg Thr Asp Trp  Trp Glu Asn Glu Thr  Ile Gly Val 
    1385                 1390                 1395             


Ala Asn  Gly Thr Asp Ser Lys  Thr Ile Arg Gln Leu  Val Trp Asp 
    1400                 1405                 1410             


Ala Met  Gln Ser Gly Val Ile  Tyr Ala Glu Glu Lys  Lys Glu Asn 
    1415                 1420                 1425             


Phe Pro  Pro Cys Met Arg Val  Glu His Ile Gly Ile  Ala Lys Pro 
    1430                 1435                 1440             


Gln Phe  Ile Arg Trp Leu Glu  Glu Trp Thr Asn Glu  Phe Cys Glu 
    1445                 1450                 1455             


Lys Tyr  Thr Lys Tyr Phe Glu  Asp Met Lys Ser Lys  Cys Asp Pro 
    1460                 1465                 1470             


Pro Lys  Gly Ala Asp Asp Cys  Asp Asp Asn Ser Asn  Ile Glu Cys 
    1475                 1480                 1485             


Lys Arg  Ala Cys Ala Asn Tyr  Thr Asn Trp Leu Asn  Pro Lys Arg 
    1490                 1495                 1500             


Ile Glu  Trp Asn Gly Met Ser  Asn Tyr Tyr Asn Lys  Ile Tyr Arg 
    1505                 1510                 1515             


Lys Ser  Asn Lys Glu Ser Glu  Asp Gly Lys Asp Tyr  Ser Met Ile 
    1520                 1525                 1530             


Met Glu  Pro Thr Val Ile Asp  Tyr Leu Asn Lys Arg  Cys His Gly 
    1535                 1540                 1545             


Glu Ile  Asn Gly Asn Tyr Ile  Cys Cys Ser Cys Lys  Asn Ile Gly 
    1550                 1555                 1560             


Glu Asn  Ser Thr Ser Gly Thr  Val Asn Lys Lys Leu  Gln Lys Lys 
    1565                 1570                 1575             


Glu Thr  Glu Cys Glu Asp Asn  Lys Gly Pro Leu Asp  Leu Met Asn 
    1580                 1585                 1590             


Glu Val  Leu Asn Lys Met Asp  Lys Lys Tyr Ser Ala  His 
    1595                 1600                 1605     


<210>  34
<211>  1592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  34

Met Asp Lys Ser Ser Ile Gly Asp Lys Ile Glu Ala Tyr Leu Glu Lys 
1               5                   10                  15      


Lys Ser Asp Glu Ser Asp Ile Glu Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Arg Lys 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr Glu 
    50                  55                  60                  


Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Ile Asp Glu Trp Lys 
65                  70                  75                  80  


Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Lys Pro Glu Asn Ile Cys 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Asn Leu 
            100                 105                 110         


Lys Phe Asp Lys Ile Arg Asp Asn Asn Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn Lys 
                165                 170                 175     


Phe Glu Pro Cys Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn Asp 
            180                 185                 190         


Lys Val Leu Gln Asp Lys Tyr Pro Asn Asp Asp Pro Lys Tyr Thr Lys 
        195                 200                 205             


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
    210                 215                 220                 


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Leu Gly Trp 
225                 230                 235                 240 


Thr Ser Ser Lys Glu Ser Glu Gly Asp Asn Lys Leu Glu Leu Cys Arg 
                245                 250                 255     


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
            260                 265                 270         


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
        275                 280                 285             


Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His Arg Glu Glu Cys 
    290                 295                 300                 


Thr Arg Lys Asn Val Glu Ser Lys Glu Gly Thr Ser Tyr Cys Thr Asn 
305                 310                 315                 320 


Cys Lys Glu Lys Cys Lys Lys Tyr Cys Glu Tyr Val Asn Lys Trp Lys 
                325                 330                 335     


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Asn Asp Leu Tyr Gln Gln 
            340                 345                 350         


Glu Asn Lys Thr Ser Ser Ser Ser Lys Lys Lys Ser Arg Tyr Asp Asp 
        355                 360                 365             


Tyr Val Lys Glu Phe Phe Lys Asn Phe Lys Gly Asp Asn Tyr Lys Ser 
    370                 375                 380                 


Leu Glu Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr 
385                 390                 395                 400 


Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Thr Glu Asn Ala Ser Glu 
                405                 410                 415     


Thr Pro Ser Lys Tyr Tyr Asp Glu Ala Cys Asn Cys Asn Glu Ser Glu 
            420                 425                 430         


Ile Ala Ser Val Gly Gln Ala Gln Thr Ser Gly Pro Ser Ser Asn Lys 
        435                 440                 445             


Thr Cys Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Glu Cys 
    450                 455                 460                 


Lys Asp Val Lys Leu Gly Ile Asn Asn Asn Asp Lys Val Leu Arg Val 
465                 470                 475                 480 


Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys 
                485                 490                 495     


Gln Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asp Lys Asn Ser Glu Glu Ile Cys 
        515                 520                 525             


Gln Lys Lys Leu Glu Lys Val Phe Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Cys Asp Lys Cys Lys Ser Gly Thr Ser Arg Ser Lys Lys Lys Trp Ile 
545                 550                 555                 560 


Trp Lys Lys Ser Ser Gly Asn Glu Glu Gly Leu Gln Lys Glu Tyr Ala 
                565                 570                 575     


Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Cys 
            580                 585                 590         


Leu His Glu Lys Glu Gly Lys Thr Gln His Lys Thr Ile Ser Thr Asn 
        595                 600                 605             


Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly Lys 
    610                 615                 620                 


Asn Leu Lys Thr Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys Lys 
625                 630                 635                 640 


Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile 
                645                 650                 655     


Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu Leu 
            660                 665                 670         


Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys Lys 
        675                 680                 685             


Asn Asn Thr Ala Glu Gln His Thr Ser Tyr Ser Ser Leu Asp Glu Leu 
    690                 695                 700                 


Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Thr Ala Met 
705                 710                 715                 720 


Lys His Gly Ala Gly Met Asn Gly Thr Thr Cys Ser Cys Ser Gly Asp 
                725                 730                 735     


Ser Ser Asn Asp Met Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg 
            740                 745                 750         


Phe Leu Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg Gln Glu Lys 
        755                 760                 765             


Val Asn Ala Val Ile Glu Asn Cys Asn Ser Cys Lys Glu Ser Gly Gly 
    770                 775                 780                 


Thr Cys Asn Ser Asp Cys Lys Thr Glu Cys Lys Asn Lys Cys Glu Ala 
785                 790                 795                 800 


Tyr Lys Glu Phe Ile Glu Asp Cys Lys Gly Gly Gly Thr Gly Thr Ala 
                805                 810                 815     


Gly Ser Pro Trp Ser Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser 
            820                 825                 830         


Lys His Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn 
        835                 840                 845             


Cys Gly Thr Ser Ser Thr Thr Asn Ala Ala Ala Ser Thr Asp Glu Asn 
    850                 855                 860                 


Lys Cys Val Gln Ser Asp Val Asp Ser Phe Phe Lys His Leu Ile Asp 
865                 870                 875                 880 


Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Asn Val Leu Asp Asp 
                885                 890                 895     


Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr 
            900                 905                 910         


Thr Thr Thr Lys Asn Cys Asp Ile Gln Lys Lys Thr Pro Lys Ser Gln 
        915                 920                 925             


Ser Cys Asp Thr Leu Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
    930                 935                 940                 


Thr Pro His Glu Tyr Lys Tyr Ala Cys Glu Cys Lys Ile Pro Thr Thr 
945                 950                 955                 960 


Glu Glu Thr Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp Ser Cys 
                965                 970                 975     


Gly Ser Ala Gln Thr Val Arg Gly Arg Ser Gly Lys Asp Asp Tyr Glu 
            980                 985                 990         


Leu Tyr Thr Tyr Asn Gly Val Lys  Glu Thr Lys Pro Leu  Gly Thr Leu 
        995                 1000                 1005             


Lys Asn  Ser Lys Leu Asp Gly  Asn Asp Val Met Phe  Phe Asn Leu 
    1010                 1015                 1020             


Phe Glu  Gln Trp Asn Lys Glu  Ile Gln Tyr Gln Ile  Glu Gln Tyr 
    1025                 1030                 1035             


Met Thr  Asn Thr Lys Ile Ser  Cys Asn Asn Glu Met  Lys Ile Leu 
    1040                 1045                 1050             


Ser Ser  Ser Ser Glu Glu Ser  Gln Asn Gln Asn Gly  Ser Asp His 
    1055                 1060                 1065             


His Asp  Gly Arg Asn Asn Asn  Ile Asn Gln Gly Thr  Asn Cys Lys 
    1070                 1075                 1080             


Lys Asn  Cys Glu Cys Tyr Ser  Leu Trp Ile Glu Lys  Ile Lys Lys 
    1085                 1090                 1095             


Gln Trp  Asp Lys Gln Lys Asp  Asn Tyr Asn Lys Phe  Gln Arg Lys 
    1100                 1105                 1110             


Gln Ile  Tyr Asp Ala Asn Lys  Gly Pro Gln Asn Lys  Lys Val Val 
    1115                 1120                 1125             


Ser Leu  Ser His Phe Leu Phe  Phe Ser Cys Trp Glu  Glu Tyr Ile 
    1130                 1135                 1140             


Gln Lys  Tyr Phe Asn Gly Asp  Trp Ser Lys Ile Lys  Asn Ile Gly 
    1145                 1150                 1155             


Ser Asp  Thr Phe Glu Phe Leu  Ile Lys Lys Cys Gly  Asn Asp Ser 
    1160                 1165                 1170             


Gly Asp  Gly Glu Thr Ile Phe  Asn Lys Lys Leu Asn  Asn Ala Asn 
    1175                 1180                 1185             


Ile Lys  Cys Asn Glu Asn Ala  Ser Lys Asp Thr Lys  Ile Asn Lys 
    1190                 1195                 1200             


Ser Glu  Thr Ser Ser Lys Gly  Ser Gly Ser Gly Asp  Lys Gly Gln 
    1205                 1210                 1215             


Asn Asn  Lys Ser Leu Cys His  Glu Lys Gly Asn Asp  Arg Thr Trp 
    1220                 1225                 1230             


Ser Lys  Lys Tyr Ile Lys Lys  Leu Glu Asn Gly Arg  Thr Leu Glu 
    1235                 1240                 1245             


Gly Val  Tyr Val Pro Pro Arg  Arg Gln Gln Leu Cys  Leu Tyr Glu 
    1250                 1255                 1260             


Leu Phe  Pro Ile Ile Ile Lys  Lys Glu Lys Asp Met  Glu Lys Ala 
    1265                 1270                 1275             


Lys Glu  Glu Leu Leu Glu Thr  Leu Gln Ile Val Ala  Glu Arg Glu 
    1280                 1285                 1290             


Ala Tyr  Tyr Leu Trp Lys Gln  Tyr His Ala His Asn  Asp Thr Thr 
    1295                 1300                 1305             


Tyr Leu  Ala His Lys Lys Ala  Cys Cys Ala Ile Arg  Gly Ser Phe 
    1310                 1315                 1320             


Tyr Asp  Leu Glu Asp Ile Ile  Lys Gly Asn Asp Leu  Val His Asp 
    1325                 1330                 1335             


Glu Tyr  Thr Lys Tyr Ile Asp  Ser Lys Leu Asn Glu  Ile Phe Gly 
    1340                 1345                 1350             


Ser Ser  Asn Lys Asn Asp Ile  Glu Thr Lys Arg Ala  Arg Thr Asp 
    1355                 1360                 1365             


Trp Trp  Glu Asn Glu Thr Ile  Asp Val Ala Asn Gly  Thr Asp Arg 
    1370                 1375                 1380             


Lys Thr  Ile Arg Gln Leu Val  Trp Asp Ala Met Gln  Ser Gly Val 
    1385                 1390                 1395             


Arg Lys  Ala Ile Asp Glu Glu  Lys Glu Lys Lys Lys  Pro Asn Lys 
    1400                 1405                 1410             


Asn Phe  Pro Pro Cys Met Gly  Val Glu His Ile Gly  Ile Ala Lys 
    1415                 1420                 1425             


Pro Gln  Phe Ile Arg Trp Leu  Glu Glu Trp Thr Asn  Glu Phe Cys 
    1430                 1435                 1440             


Glu Glu  Tyr Thr Lys Tyr Phe  Gly Ala Ile Asn Ser  Asn Cys Asn 
    1445                 1450                 1455             


Leu Arg  Lys Gly Ala Asp Asp  Cys Gly Asp Asn Ser  Asn Ile Glu 
    1460                 1465                 1470             


Cys Lys  Arg Ala Cys Ala Asn  Tyr Thr Asn Trp Leu  Asn Pro Lys 
    1475                 1480                 1485             


Arg Ile  Glu Trp Asn Gly Met  Ser Asn Tyr Tyr Asn  Lys Ile Tyr 
    1490                 1495                 1500             


Arg Lys  Ser Asn Lys Glu Ser  Glu Asp Gly Lys Asp  Tyr Ser Met 
    1505                 1510                 1515             


Ile Met  Glu Pro Thr Val Ile  Asp Tyr Leu Asn Lys  Arg Cys Asn 
    1520                 1525                 1530             


Gly Glu  Ile Asn Gly Asn Tyr  Ile Cys Cys Ser Cys  Lys Asn Ile 
    1535                 1540                 1545             


Gly Glu  Asn Ser Thr Ser Pro  Val Ala Asn Lys Lys  Ala Gln Arg 
    1550                 1555                 1560             


Lys Glu  Thr Glu Cys Glu Glu  Glu Lys Gly Pro Leu  Asp Leu Met 
    1565                 1570                 1575             


Asn Glu  Val Leu Asn Lys Met  Asp Glu Lys Tyr Ser  Ala His 
    1580                 1585                 1590         


<210>  35
<211>  1614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  35

Met Asp Lys Ser Ser Ile Gly Asp Lys Ile Glu Glu Tyr Leu Lys Glu 
1               5                   10                  15      


Lys Ser Asn Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Arg Ser Gly Gly Asp Gly Tyr Tyr Leu Lys Asn 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Asp Glu Asn Leu Tyr Lys Ala Ser Glu Asn Asn Lys Asn Ile Phe 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Lys Leu 
            100                 105                 110         


Asn Val Glu Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Leu Ala Asp Ile Ile Arg Gly Arg Asp Gly Asn Lys Cys Glu Thr Lys 
                165                 170                 175     


Ser Thr Asn Asn Val Glu Glu Leu Ile Lys Lys Phe Phe Glu Lys Asn 
            180                 185                 190         


Tyr Arg Glu Asn Lys Glu Tyr Lys Arg Lys Tyr Arg Asn Asp Asp Pro 
        195                 200                 205             


Lys Tyr Thr Lys Leu Arg Glu Asp Trp Trp Thr Lys Asn Arg Gln Lys 
    210                 215                 220                 


Val Trp Glu Val Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile 
225                 230                 235                 240 


Lys Arg Arg Trp Arg Thr Ser Gly Lys Ser Asn Gly Glu Asn Lys Leu 
                245                 250                 255     


Glu Leu Cys Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Lys 
            260                 265                 270         


Leu Asp Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu 
        275                 280                 285             


Asp Leu Tyr Arg Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His 
    290                 295                 300                 


Arg Glu Glu Cys Thr Ser Glu Asp Asp Lys Ser Lys Glu Val Thr Ser 
305                 310                 315                 320 


Tyr Cys Asn Met Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Tyr Val 
                325                 330                 335     


Asn Lys Trp Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu 
            340                 345                 350         


Leu Tyr Glu Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Ala Ser Arg 
        355                 360                 365             


Tyr Asp Asp Tyr Val Lys Asp Phe Phe Lys Lys Leu Asn Glu Ala Asn 
    370                 375                 380                 


Tyr Lys Ser Leu Asp Asp Tyr Ile Lys Asp Asp Pro Tyr Ser Lys Glu 
385                 390                 395                 400 


Tyr Val Thr Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Thr 
                405                 410                 415     


Ser Ser Gly Glu Thr Ala Asn His Asn Asp Glu Ala Cys Asn Pro Asn 
            420                 425                 430         


Glu Ser Glu Ile Ser Ser Val Gly Gln Ala Pro Ile Ser Asp Pro Ser 
        435                 440                 445             


Ser Asn Lys Thr Cys Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys 
    450                 455                 460                 


Lys Glu Cys Lys His Val Lys Leu Gly Val Arg Glu Asn Asp Lys Val 
465                 470                 475                 480 


Leu Arg Val Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn 
                485                 490                 495     


Cys Cys Cys Gln Asp Leu Leu Gly Met Leu Gln Glu Pro Arg Ile Asp 
            500                 505                 510         


Lys Asn Gln Arg Gly Ser Ser Ser Asn Gly Ser Cys Asp Lys Asn Ser 
        515                 520                 525             


Glu Glu Ile Cys Gln Lys Lys Leu Asp Glu Ala Leu Ala Ser Leu Thr 
    530                 535                 540                 


Asn Gly Tyr Lys Cys Asp Lys Cys Lys Ser Gly Thr Ser Thr Val Asn 
545                 550                 555                 560 


Lys Asn Trp Ile Trp Lys Lys Tyr Ser Gly Lys Glu Gly Gly Leu Gln 
                565                 570                 575     


Glu Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu 
            580                 585                 590         


Cys Leu Val Cys Leu His Glu Lys Glu Gly Lys Thr Gln His Lys Thr 
        595                 600                 605             


Ile Ser Thr Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Asp Ala Phe 
    610                 615                 620                 


His Glu Gly Lys Asn Leu Lys Thr Ser His Gln Asn Lys Asn Ser Gly 
625                 630                 635                 640 


Asn Lys Glu Asn Leu Cys Lys Asp Leu Lys Tyr Ser Phe Ala Asp Tyr 
                645                 650                 655     


Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys 
            660                 665                 670         


Asp Leu Glu Leu Asn Leu Gln Lys Ala Phe Gly Lys Leu Phe Arg Lys 
        675                 680                 685             


Tyr Ile Lys Lys Asn Asn Thr Ala Glu Gln His Thr Ser Tyr Ser Ser 
    690                 695                 700                 


Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile 
705                 710                 715                 720 


Trp Leu Ala Met Lys His Gly Ala Gly Met Asn Gly Thr Thr Cys Cys 
                725                 730                 735     


Gly Asp Gly Ser Val Thr Gly Ser Ser Asp Ser Gly Ser Thr Thr Cys 
            740                 745                 750         


Ser Gly Asp Asn Gly Ser Ile Ser Cys Asp Asp Ile Pro Thr Ile Asp 
        755                 760                 765             


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
    770                 775                 780                 


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Thr Asn Cys Asn 
785                 790                 795                 800 


Ser Cys Lys Asn Thr Ser Ser Lys Thr Lys Leu Gly Gly Thr Cys Asn 
                805                 810                 815     


Ser Asp Cys Glu Lys Lys Cys Lys Asp Glu Cys Glu Lys Tyr Lys Lys 
            820                 825                 830         


Phe Ile Glu Glu Phe Cys Thr Ala Ala Gly Gly Thr Ser Gly Ser Pro 
        835                 840                 845             


Trp Ser Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile 
    850                 855                 860                 


Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly Pro 
865                 870                 875                 880 


Ser Ser Thr Thr Ser Thr Ala Glu Asn Lys Cys Val Gln Ser Asp Ile 
                885                 890                 895     


Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser 
            900                 905                 910         


Ser Tyr Leu Ser Ile Val Leu Asp Glu Asn Asn Cys Gly Glu Asp Asn 
        915                 920                 925             


Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Lys Asn Cys Asp 
    930                 935                 940                 


Ile Gln Lys Lys Thr Pro Lys Ser Gln Ser Cys Asn Thr Ala Val Val 
945                 950                 955                 960 


Val Asn Val Pro Ser Pro Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr 
                965                 970                 975     


Ala Cys Gln Cys Lys Ile Pro Thr Thr Glu Glu Ser Cys Asp Asp Arg 
            980                 985                 990         


Lys Glu Tyr Met Asn Gln Trp Ser  Ser Gly Ser Ala Gln  Thr Val Arg 
        995                 1000                 1005             


Gly Arg  Ser Thr Asn Asn Asp  Tyr Glu Leu Tyr Thr  Tyr Asn Gly 
    1010                 1015                 1020             


Val Lys  Glu Thr Lys Leu Pro  Lys Lys Leu Asn Ser  Ser Lys Leu 
    1025                 1030                 1035             


Asp Gly  Asn Asp Val Met Phe  Phe Asn Leu Phe Glu  Gln Trp Asn 
    1040                 1045                 1050             


Lys Glu  Ile Gln Tyr Gln Ile  Glu Gln Tyr Met Thr  Asn Ala Asn 
    1055                 1060                 1065             


Ile Ser  Cys Asn Asn Glu Met  Asn Val Leu Ser Ser  Ser Ser Glu 
    1070                 1075                 1080             


Glu Ser  Lys Asn Gln Asn Gly  Ser Asp His Pro Asp  Gly Arg Asn 
    1085                 1090                 1095             


Asn Asn  Ile Asn Gln Gly Thr  Asn Cys Lys Glu Lys  Cys Lys Cys 
    1100                 1105                 1110             


Tyr Glu  Leu Trp Ile Lys Lys  Ile Lys Glu Gln Trp  Gly Lys Gln 
    1115                 1120                 1125             


Lys Asp  Asn Tyr Asn Lys Phe  Glu Lys Lys Thr Ser  Asn Asp Ala 
    1130                 1135                 1140             


Arg Lys  Ser Ser Gln Asn Lys  Lys Val Val Ser Leu  Ser His Phe 
    1145                 1150                 1155             


Leu Phe  Phe Ser Cys Trp Glu  Glu Tyr Ile Gln Lys  Tyr Phe Asn 
    1160                 1165                 1170             


Gly Asp  Trp Ser Lys Ile Lys  Asn Ile Gly Ser Asp  Thr Phe Asp 
    1175                 1180                 1185             


Phe Leu  Ile Lys Lys Cys Gly  Asn Asp Ser Ala His  Gly Glu Thr 
    1190                 1195                 1200             


Ile Phe  Asn Lys Lys Leu Asn  Asn Ala Asn Ile Lys  Cys Asn Glu 
    1205                 1210                 1215             


Asn Glu  Ser Thr Asn Asn Lys  Met Lys Ser Ser Glu  Thr Ser Gly 
    1220                 1225                 1230             


Ser Gly  Ser Gly Ala Glu Lys  Lys Asn Asn Lys Ser  Leu Cys His 
    1235                 1240                 1245             


Glu Lys  Gly Asn Asp Arg Thr  Trp Ser Lys Lys Tyr  Ile Lys Lys 
    1250                 1255                 1260             


Leu Glu  Asn Gly Arg Thr Leu  Glu Gly Val Tyr Val  Pro Pro Arg 
    1265                 1270                 1275             


Arg Gln  Gln Leu Cys Leu Tyr  Glu Leu Phe Pro Ile  Ile Ile Lys 
    1280                 1285                 1290             


Asn Glu  Glu Gly Met Glu Lys  Ala Lys Glu Glu Leu  Leu Glu Thr 
    1295                 1300                 1305             


Leu Gln  Ile Ala Ala Glu Arg  Glu Ala Tyr Tyr Leu  Trp Lys Gln 
    1310                 1315                 1320             


Tyr His  Ala His Asn Asp Thr  Thr Tyr Leu Ala His  Lys Lys Ala 
    1325                 1330                 1335             


Cys Cys  Ala Ile Arg Gly Ser  Phe Tyr Asp Leu Glu  Asp Ile Ile 
    1340                 1345                 1350             


Lys Gly  Asn Asp Leu Val His  Asp Glu Tyr Thr Lys  Tyr Ile Asp 
    1355                 1360                 1365             


Ser Lys  Leu Asn Lys Ile Phe  Gly Ser Ser Asn Lys  Asn Asp Ile 
    1370                 1375                 1380             


Glu Thr  Lys Arg Ala Arg Thr  Asp Trp Trp Glu Asn  Glu Ala Ile 
    1385                 1390                 1395             


Gly Val  Ala Asn Gly Thr Asp  His Lys Thr Ile Arg  Gln Leu Val 
    1400                 1405                 1410             


Trp Asp  Ala Met Gln Ser Gly  Val Arg Tyr Ala Val  Glu Glu Lys 
    1415                 1420                 1425             


Lys Lys  Lys Lys Gln Asn Glu  Asn Phe Pro Pro Cys  Met Gly Val 
    1430                 1435                 1440             


Glu His  Ile Gly Ile Ala Lys  Pro Gln Phe Ile Arg  Trp Leu Glu 
    1445                 1450                 1455             


Glu Trp  Thr Asn Glu Phe Cys  Glu Glu Tyr Thr Lys  Tyr Phe Gly 
    1460                 1465                 1470             


Ala Ile  Asn Ser Lys Cys Asn  Leu Arg Lys Gly Ala  Asp Asp Cys 
    1475                 1480                 1485             


Asp Asp  Asn Ser Asn Ile Glu  Cys Lys Arg Ala Cys  Ala Asn Tyr 
    1490                 1495                 1500             


Thr Asn  Trp Leu Asn Pro Lys  Arg Ile Glu Trp Asn  Gly Met Ser 
    1505                 1510                 1515             


Asn Tyr  Tyr Asn Lys Ile Tyr  Arg Lys Ser Asn Lys  Glu Ser Glu 
    1520                 1525                 1530             


Asp Gly  Lys Asp Tyr Ser Met  Ile Met Glu Pro Thr  Val Ile Asp 
    1535                 1540                 1545             


Tyr Leu  Asn Lys Arg Cys His  Gly Glu Ile Asn Gly  Asn Tyr Ile 
    1550                 1555                 1560             


Cys Cys  Ser Cys Lys Asn Ile  Gly Glu Asn Ser Thr  Ser Pro Val 
    1565                 1570                 1575             


Ala Asn  Lys Lys Ala Gln Arg  Lys Asp Glu Gln Cys  Glu Asp Asn 
    1580                 1585                 1590             


Lys Gly  Pro Leu Asp Leu Met  Asn Glu Val Leu Asn  Lys Met Asp 
    1595                 1600                 1605             


Glu Lys  Tyr Ser Glu His 
    1610                 


<210>  36
<211>  1609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  36

Met Asp Ser Lys Thr Thr Ile Gly Asp Lys Ile Glu Ala Tyr Leu Glu 
1               5                   10                  15      


Lys Lys Ser Asn Glu Ser Asp Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Arg 
        35                  40                  45              


Lys Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Glu Pro Cys Asp Ser Ile Pro Pro Pro Tyr Gly Asp Ile Asp Glu Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Lys Pro Glu Asn Val 
                85                  90                  95      


Phe Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Asn 
            100                 105                 110         


Leu Asn Val Glu Arg Ile Arg Asp Asn Asn Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Ile Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Lys Asn Ile Leu Glu 
            180                 185                 190         


Lys Gly Ser Thr Ile Gln Ser Asn Tyr Ser Lys Lys Asp Gln Asn Tyr 
        195                 200                 205             


Thr Lys Leu Arg Glu Asp Trp Trp Thr Lys Asn Arg Gln Lys Val Trp 
    210                 215                 220                 


Glu Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg 
225                 230                 235                 240 


Arg Trp Thr Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys Leu Glu Leu 
                245                 250                 255     


Cys Arg Lys Cys Gly His Tyr Glu Gly Lys Val Pro Thr Lys Leu Asp 
            260                 265                 270         


Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe 
        275                 280                 285             


Tyr Arg Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His Arg Glu 
    290                 295                 300                 


Glu Cys Thr Arg Glu Asp His Lys Ser Lys Glu Gly Ala Ser Tyr Cys 
305                 310                 315                 320 


Ser Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys 
                325                 330                 335     


Trp Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Lys Asp Leu Tyr 
            340                 345                 350         


Gln Gln Glu Asn Glu Thr Ser Ser Ser Ser Lys Lys Lys Ser Arg Tyr 
        355                 360                 365             


Asp Asp Tyr Val Lys Glu Phe Phe Lys Asn Phe Lys Gly Asp Asn Tyr 
    370                 375                 380                 


Lys Ser Leu Asp Asp Tyr Ile Lys Gly Asp Pro Tyr Ser Lys Glu Tyr 
385                 390                 395                 400 


Thr Thr Lys Leu Ser Phe Ile Leu Asn Pro Ser Asp Ala Asn Thr Ser 
                405                 410                 415     


Ser Glu Lys Ile Gln Lys Asn Asn Asp Glu Ala Cys Asn Cys Asn Glu 
            420                 425                 430         


Ser Glu Ile Ala Ser Val Glu Gln Ala Ser Ile Ser Asp Arg Ser Ser 
        435                 440                 445             


Gln Lys Ala Tyr Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys 
    450                 455                 460                 


Val Cys Lys His Val Lys Leu Gly Val Arg Glu Asn Asp Lys Val Leu 
465                 470                 475                 480 


Arg Val Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Glu Asn Cys 
                485                 490                 495     


Cys Phe Lys Asp Phe Leu Arg Ile Val Glu Glu Pro Arg Ile Asp Lys 
            500                 505                 510         


Asn Gln Arg Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Asn Asn Glu 
        515                 520                 525             


Glu Ala Cys Glu Lys Asn Leu Asp Glu Ala Leu Ala Ser Leu Thr Asn 
    530                 535                 540                 


Cys Tyr Lys Cys Asp Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn 
545                 550                 555                 560 


Asn Lys Trp Ile Trp Arg Lys Phe Pro Gly Asn Gly Glu Gly Leu Gln 
                565                 570                 575     


Lys Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu 
            580                 585                 590         


Cys Leu Val Cys Leu His Glu Lys Glu Gly Lys Thr Gln Glu Leu Lys 
        595                 600                 605             


Asn Ile Arg Thr Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Asp Ala 
    610                 615                 620                 


Phe His Glu Gly Lys Asn Leu Lys Thr Ser His Gln Lys Lys Asn Ala 
625                 630                 635                 640 


Glu Asn Lys Lys Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp 
                645                 650                 655     


Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr 
            660                 665                 670         


Lys Asp Leu Glu Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg 
        675                 680                 685             


Lys Tyr Ile Lys Lys Asn Ile Ser Thr Glu Gln His Thr Ser Tyr Ser 
    690                 695                 700                 


Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr 
705                 710                 715                 720 


Ile Trp Thr Ala Met Lys His Gly Ala Glu Met Asn Ser Thr Met Cys 
                725                 730                 735     


Asn Val Asp Gly Ser Val Thr Gly Ser Ser Asp Ser Gly Ser Thr Thr 
            740                 745                 750         


Cys Ser Gly Asp Asn Gly Ser Ile Ser Cys Asp Asp Ile Pro Thr Ile 
        755                 760                 765             


Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His 
    770                 775                 780                 


Phe Cys Lys Gln Arg Gln Ala Lys Val Asn Ala Val Ile Lys Asn Cys 
785                 790                 795                 800 


Asn Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Asp Cys Lys Thr 
                805                 810                 815     


Lys Cys Lys Val Ala Cys Asp Ala Tyr Lys Lys Phe Ile Glu Glu Cys 
            820                 825                 830         


Arg Thr Ala Ala Glu Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp 
        835                 840                 845             


Tyr Gln Ile Tyr Met Arg Tyr Ser Lys His Ile Glu Asp Ala Lys Arg 
    850                 855                 860                 


Asn Arg Lys Ala Gly Thr Lys Ser Cys Gly Thr Ser Thr Ala Glu Ser 
865                 870                 875                 880 


Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp 
                885                 890                 895     


Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Asn Val Leu Asp Glu 
            900                 905                 910         


Asn Asn Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr 
        915                 920                 925             


Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Lys Asn Cys Asp Ile Gln Lys 
    930                 935                 940                 


Asp Lys Ser Lys Ser Gln Ser Cys Asn Thr Ala Val Val Val Asn Val 
945                 950                 955                 960 


Pro Ser Pro Leu Gly Asn Thr Pro Tyr Glu Tyr Lys Tyr Ala Cys Glu 
                965                 970                 975     


Cys Lys Ile Pro Thr Thr Glu Glu Thr Cys Asp Asp Arg Lys Glu Tyr 
            980                 985                 990         


Met Asn Gln Trp Ile Ser Asp Asn  Thr Lys Asn Pro Lys  Gly Ser Gly 
        995                 1000                 1005             


Ser Thr  Asn Asn Asp Tyr Glu  Leu Tyr Thr Tyr Asn  Gly Val Gln 
    1010                 1015                 1020             


Ile Lys  Gln Ala Ala Gly Arg  Ser Ser Ser Thr Lys  Leu Asp Asp 
    1025                 1030                 1035             


Lys Asp  Val Met Phe Phe Asn  Leu Phe Glu Gln Trp  Asn Lys Glu 
    1040                 1045                 1050             


Ile Gln  Tyr Gln Ile Glu Gln  Tyr Met Thr Asn Thr  Lys Ile Ser 
    1055                 1060                 1065             


Cys Ile  Asp Glu Lys Glu Val  Leu Asp Ser Val Ser  Asp Glu Gly 
    1070                 1075                 1080             


Thr Pro  Lys Val Arg Gly Gly  Tyr Glu Asp Gly Arg  Asn Asn Asn 
    1085                 1090                 1095             


Thr Asp  Gln Gly Thr Asn Cys  Lys Glu Lys Cys Glu  Cys Tyr Lys 
    1100                 1105                 1110             


Leu Trp  Met Glu Lys Ile Lys  Lys Gln Trp Glu Thr  Gln Asn Gln 
    1115                 1120                 1125             


Asn Tyr  Asn Lys Phe Glu Lys  Lys Thr Ser Ser Tyr  Ala Asn Lys 
    1130                 1135                 1140             


Gly Pro  Gln Asn Lys Lys Val  Val Ser Leu Ser His  Phe Leu Phe 
    1145                 1150                 1155             


Phe Ser  Cys Trp Glu Glu Tyr  Ile Gln Lys Tyr Phe  Asn Gly Asp 
    1160                 1165                 1170             


Trp Ser  Lys Ile Lys Asn Ile  Gly Ser Asp Thr Phe  Glu Tyr Leu 
    1175                 1180                 1185             


Ile Lys  Lys Cys Gly Asn Asp  Ser Gly Asp Gly Glu  Thr Ile Phe 
    1190                 1195                 1200             


Asn Lys  Lys Leu Lys Asn Ala  His Ile Lys Cys Asn  Glu Asn Ala 
    1205                 1210                 1215             


Ser Lys  Asn Thr Lys Ile Asn  Lys Ser Glu Thr Ser  Ser Asp Gly 
    1220                 1225                 1230             


Ser Gly  Ser Gly Asp Lys Gly  Gln Ser Asn Lys Ser  Leu Cys His 
    1235                 1240                 1245             


Glu Lys  Gly Asn Asp Arg Thr  Trp Ser Lys Lys Tyr  Ile Lys Lys 
    1250                 1255                 1260             


Leu Glu  Asn Gly Arg Thr Leu  Glu Gly Val Tyr Val  Pro Pro Arg 
    1265                 1270                 1275             


Arg Gln  Gln Leu Cys Leu Tyr  Glu Leu Phe Pro Ile  Ile Ile Lys 
    1280                 1285                 1290             


Lys Glu  Lys Asp Met Glu Asn  Val Lys Lys Glu Leu  Leu Glu Thr 
    1295                 1300                 1305             


Leu Gln  Ile Val Ala Glu Arg  Glu Ala Tyr Tyr Leu  Trp Lys Gln 
    1310                 1315                 1320             


Tyr Asn  Pro Thr Gly Lys Gly  Ile Asp Asp Ala Asn  Lys Lys Ala 
    1325                 1330                 1335             


Cys Cys  Ala Ile Arg Gly Ser  Phe Tyr Asp Leu Glu  Asp Ile Ile 
    1340                 1345                 1350             


Lys Gly  Asn Asp Leu Val His  Asp Glu Tyr Thr Lys  Tyr Ile Asp 
    1355                 1360                 1365             


Ser Lys  Leu Asn Glu Ile Phe  Gly Ser Ser Asn Lys  Asn Asp Ile 
    1370                 1375                 1380             


Glu Thr  Lys Arg Ala Arg Thr  Asp Trp Trp Glu Asn  Glu Thr Ile 
    1385                 1390                 1395             


Thr Asn  Arg Thr Asp Arg Lys  Thr Ile Arg Gln Leu  Val Trp Asp 
    1400                 1405                 1410             


Ala Met  Gln Ser Gly Val Arg  Tyr Ala Val Glu Glu  Lys Asn Glu 
    1415                 1420                 1425             


Asn Phe  Pro Pro Cys Met Gly  Val Glu His Ile Gly  Ile Ala Lys 
    1430                 1435                 1440             


Pro Gln  Phe Ile Arg Trp Leu  Glu Glu Trp Thr Asn  Glu Phe Cys 
    1445                 1450                 1455             


Glu Glu  Tyr Thr Lys Tyr Phe  Glu Asp Met Lys Ser  Lys Cys Asp 
    1460                 1465                 1470             


Leu Arg  Lys Gly Ala Asp Asp  Cys Gly Asp Asn Thr  Asn Ile Glu 
    1475                 1480                 1485             


Cys Lys  Arg Ala Cys Ala Asn  Tyr Thr Asn Trp Leu  Asn Pro Lys 
    1490                 1495                 1500             


Arg Ile  Glu Trp Asn Gly Met  Ser Asn Tyr Tyr Asn  Lys Ile Tyr 
    1505                 1510                 1515             


Arg Lys  Ser Asn Lys Glu Ser  Glu Asp Gly Lys Asp  Tyr Ser Met 
    1520                 1525                 1530             


Ile Met  Glu Pro Thr Val Ile  Asp Tyr Leu Asn Lys  Arg Cys Asn 
    1535                 1540                 1545             


Gly Glu  Ile Asn Gly Asn Tyr  Ile Cys Cys Ser Cys  Lys Asn Ile 
    1550                 1555                 1560             


Gly Glu  Asn Tyr Asn Pro Ser  Pro Ala Gln Lys Thr  Lys Gly Ser 
    1565                 1570                 1575             


Lys Lys  Lys Asp Glu Gln Cys  Glu Asp Asn Lys Gly  Pro Leu Asp 
    1580                 1585                 1590             


Leu Met  Asn Glu Val Leu Asn  Lys Met Asp Pro Lys  Tyr Ser Lys 
    1595                 1600                 1605             


Leu 
    


<210>  37
<211>  1633
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  37

Met Asp Ser Thr Ser Thr Ile Ala Asn Lys Ile Glu Glu Tyr Leu Lys 
1               5                   10                  15      


Glu Lys Ser Asn Glu Ser Asp Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Arg 
        35                  40                  45              


Lys Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Asp Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Asp Glu Asn Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Asn 
            100                 105                 110         


Leu Asn Val Glu Arg Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Ile Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Lys Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu 
            180                 185                 190         


Asn Asp Lys Val Leu Gln Asp Lys Tyr Pro Asn Asp Asp Pro Lys Tyr 
        195                 200                 205             


Thr Lys Leu Arg Glu Gly Trp Trp Asn Ala Asn Arg Gln Lys Val Trp 
    210                 215                 220                 


Glu Val Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg 
225                 230                 235                 240 


Arg Trp Thr Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys Leu Glu Leu 
                245                 250                 255     


Cys Arg Lys Cys Gly His Tyr Glu Gly Lys Val Pro Thr Tyr Leu Asp 
            260                 265                 270         


Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe 
        275                 280                 285             


Tyr Arg Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His Arg Glu 
    290                 295                 300                 


Glu Cys Thr Arg Glu Asp Asp Lys Cys Lys Glu Gly Ala Ser Tyr Cys 
305                 310                 315                 320 


Ser Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys 
                325                 330                 335     


Trp Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr 
            340                 345                 350         


Glu Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp 
        355                 360                 365             


Asn Tyr Val Lys Asp Phe Phe Glu Lys Leu Glu Ala Asn Tyr Lys Ser 
    370                 375                 380                 


Leu Asp Asp Tyr Ile Lys Asp Asp Pro Tyr Phe Ala Glu Tyr Ala Thr 
385                 390                 395                 400 


Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Gly 
                405                 410                 415     


Glu Thr Ala Asn His Asn Asp Glu Val Cys Asn Pro Asn Glu Ser Glu 
            420                 425                 430         


Ile Ser Ser Val Gly Gln Ala Gln Thr Ser Gly Pro Ser Ser Asn Lys 
        435                 440                 445             


Thr Cys Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Val Cys 
    450                 455                 460                 


Lys Tyr Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Lys Ile 
465                 470                 475                 480 


Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys 
                485                 490                 495     


Gln Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Asn Asn Glu Glu Ala Cys 
        515                 520                 525             


Glu Lys Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Asn Gln Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Asn Lys Trp 
545                 550                 555                 560 


Ile Trp Lys Lys Ser Ser Gly Asn Gly Glu Gly Leu Gln Lys Glu Tyr 
                565                 570                 575     


Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Tyr Leu Gly 
            580                 585                 590         


Asn Leu Arg Lys Leu Gly Asn Val Cys Glu Asp Val Lys Asp Ile Asn 
        595                 600                 605             


Phe Asp Thr Lys Glu Lys Phe Leu Ala Gly Cys Leu Ile Ala Ala Phe 
    610                 615                 620                 


His Glu Gly Lys Asn Leu Lys Thr Thr Tyr Leu Glu Lys Lys Lys Gly 
625                 630                 635                 640 


Asp Asn Gly Lys Lys Leu Cys Lys Asp Leu Lys Tyr Ser Phe Ala Asp 
                645                 650                 655     


Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Asp Phe Thr 
            660                 665                 670         


Lys Asn Val Glu Leu Asn Leu Gln Gln Ile Phe Gly Lys Leu Phe Arg 
        675                 680                 685             


Lys Tyr Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser 
    690                 695                 700                 


Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr 
705                 710                 715                 720 


Ile Trp Leu Ala Met Lys His Gly Ala Gly Met Asn Gly Thr Thr Cys 
                725                 730                 735     


Ser Ser Gly Ser Gly Asp Asn Gly Asp Ser Ser Ile Thr Gly Ser Ser 
            740                 745                 750         


Asp Ser Gly Ser Thr Thr Cys Ser Gly Asp Asn Gly Ser Ile Ser Cys 
        755                 760                 765             


Asp Asp Ile Pro Thr Ile Asp Phe Ile Pro Gln Tyr Leu Arg Phe Leu 
    770                 775                 780                 


Gln Glu Trp Val Glu Asn Phe Cys Glu Gln Arg Gln Ala Lys Val Asn 
785                 790                 795                 800 


Ala Val Ile Asn Ser Cys Asn Ser Cys Lys Asn Thr Ser Gly Glu Arg 
                805                 810                 815     


Lys Ile Gly Asp Thr Cys Asn Ser Asp Cys Lys Thr Glu Cys Lys Asn 
            820                 825                 830         


Lys Cys Glu Ala Tyr Lys Thr Phe Ile Asp Asn Val Gly Asp Gly Thr 
        835                 840                 845             


Ala Gly Ser Pro Trp Val Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr 
    850                 855                 860                 


Ser Lys His Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys 
865                 870                 875                 880 


Asn Cys Gly Ile Thr Thr Gly Thr Ile Ser Gly Glu Ser Ser Gly Ala 
                885                 890                 895     


Thr Ser Gly Val Thr Thr Thr Glu Asn Lys Cys Val Gln Ser Asp Ile 
            900                 905                 910         


Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser 
        915                 920                 925             


Ser Tyr Leu Ser Ile Val Leu Asp Glu Asn Asn Cys Gly Glu Asp Lys 
    930                 935                 940                 


Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Tyr Thr Thr Tyr Thr 
945                 950                 955                 960 


Thr Thr Lys Asn Cys Asp Ile Gln Lys Asp Lys Ser Lys Leu Gln Gln 
                965                 970                 975     


Ser Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly Asn Thr 
            980                 985                 990         


Pro His Glu Tyr Lys Tyr Ala Cys  Gln Cys Lys Ile Pro  Thr Thr Glu 
        995                 1000                 1005             


Glu Thr  Cys Asp Asp Arg Lys  Glu Tyr Met Asn Gln  Trp Ile Ile 
    1010                 1015                 1020             


Asp Asn  Thr Lys Asn Pro Lys  Gly Ser Arg Ser Thr  Asn Asn Asp 
    1025                 1030                 1035             


Tyr Glu  Leu Tyr Thr Tyr Asn  Gly Val Lys Glu Thr  Lys Pro Leu 
    1040                 1045                 1050             


Gly Thr  Leu Lys Ser Ser Lys  Leu Asp Asp Lys Asp  Val Met Phe 
    1055                 1060                 1065             


Phe Asn  Leu Phe Glu Gln Trp  Asn Lys Glu Ile Gln  Tyr Glu Ile 
    1070                 1075                 1080             


Glu Gln  Tyr Met Thr Asn Thr  Lys Ile Ser Cys Asn  Asn Glu Met 
    1085                 1090                 1095             


Lys Val  Leu Ser Ser Ser Ser  Glu Glu Ser Gln Asn  Gln Asn Gly 
    1100                 1105                 1110             


Ser Asp  His His Asp Gly Arg  Asn Asn Asn Ile Asn  Gln Gly Thr 
    1115                 1120                 1125             


Asn Cys  Lys Lys Asn Cys Glu  Cys Tyr Ser Leu Trp  Met Glu Lys 
    1130                 1135                 1140             


Ile Lys  Lys Gln Trp Gly Lys  Gln Lys Asn Asn Tyr  Asn Lys Phe 
    1145                 1150                 1155             


Gln Arg  Lys Gln Ile Tyr Asp  Gly Asn Asn Ala Ser  His Lys Lys 
    1160                 1165                 1170             


Glu Ile  Val Lys Leu Ser Asn  Phe Leu Phe Phe Ser  Cys Trp Glu 
    1175                 1180                 1185             


Glu Tyr  Ile Gln Lys Tyr Phe  Asn Gly Asp Trp Ser  Lys Ile Lys 
    1190                 1195                 1200             


Asn Ile  Gly Ser Asp Thr Phe  Glu Tyr Leu Ile Lys  Lys Cys Gly 
    1205                 1210                 1215             


Asn Asp  Ser Gly Asp Gly Glu  Thr Ile Phe Asn Lys  Lys Leu Lys 
    1220                 1225                 1230             


Asn Ala  His Ile Lys Cys Asn  Glu Asn Glu Ser Thr  Asp Thr Lys 
    1235                 1240                 1245             


Ile Asn  Lys Ser Glu Thr Ser  Ser Asp Gly Ser Gly  Ser Gly Asp 
    1250                 1255                 1260             


Lys Gly  Gln Asn Asn Lys Ser  Leu Cys His Glu Lys  Gly Asn Asp 
    1265                 1270                 1275             


Arg Thr  Trp Ser Lys Lys Tyr  Ile Lys Lys Leu Glu  Asn Gly Arg 
    1280                 1285                 1290             


Ser Leu  Glu Gly Val Tyr Val  Pro Pro Arg Arg Gln  Gln Leu Cys 
    1295                 1300                 1305             


Leu Tyr  Glu Leu Phe Pro Ile  Ile Ile Lys Lys Glu  Lys Asp Met 
    1310                 1315                 1320             


Glu Lys  Ala Lys Glu Glu Leu  Leu Glu Thr Leu Lys  Ile Val Ala 
    1325                 1330                 1335             


Glu Arg  Glu Ala Tyr Tyr Leu  Trp Lys Gln Tyr His  Ala His Asn 
    1340                 1345                 1350             


Asp Thr  Thr Tyr Leu Ala His  Lys Lys Ala Cys Cys  Ala Ile Arg 
    1355                 1360                 1365             


Gly Ser  Phe Tyr Asp Leu Glu  Asp Ile Ile Lys Gly  Asn Asp Leu 
    1370                 1375                 1380             


Val His  Asp Glu Tyr Thr Lys  Tyr Ile Asp Ser Lys  Leu Asn Glu 
    1385                 1390                 1395             


Ile Phe  Gly Ser Ser Asn Thr  Asn Asn Ile Asp Thr  Lys Arg Ala 
    1400                 1405                 1410             


Arg Thr  Asp Trp Trp Glu Asn  Glu Thr Ile Thr Asn  Gly Pro Asp 
    1415                 1420                 1425             


Arg Lys  Thr Ile Arg Gln Leu  Val Trp Asp Ala Met  Gln Ser Gly 
    1430                 1435                 1440             


Val Arg  Tyr Ala Val Glu Glu  Lys Lys Glu Asn Phe  Pro Pro Cys 
    1445                 1450                 1455             


Met Gly  Val Glu His Ile Gly  Ile Ala Lys Pro Gln  Phe Ile Arg 
    1460                 1465                 1470             


Trp Leu  Glu Glu Trp Thr Asn  Glu Phe Cys Glu Glu  Tyr Thr Lys 
    1475                 1480                 1485             


Tyr Phe  Glu Asp Met Lys Ser  Lys Cys Asp Pro Pro  Lys Ser Ala 
    1490                 1495                 1500             


Asp Asp  Cys Gly Asp Asn Thr  Asn Ile Glu Cys Lys  Lys Ala Cys 
    1505                 1510                 1515             


Ala Asn  Tyr Thr Asn Trp Leu  Asn Pro Lys Arg Ile  Glu Trp Asn 
    1520                 1525                 1530             


Gly Met  Ser Asn Tyr Tyr Asn  Lys Ile Tyr Arg Lys  Ser Asn Lys 
    1535                 1540                 1545             


Glu Ser  Glu Asp Gly Lys Asp  Tyr Ser Met Ile Met  Glu Pro Thr 
    1550                 1555                 1560             


Val Ile  Asp Tyr Leu Asn Lys  Arg Cys Asn Gly Glu  Ile Asn Gly 
    1565                 1570                 1575             


Asn Tyr  Ile Cys Cys Ser Cys  Lys Asn Ile Gly Ala  Tyr Asn Thr 
    1580                 1585                 1590             


Thr Ser  Gly Thr Val Asn Lys  Lys Leu Gln Lys Lys  Glu Thr Glu 
    1595                 1600                 1605             


Cys Glu  Asp Asn Lys Gly Pro  Leu Asp Leu Met Asn  Glu Val Leu 
    1610                 1615                 1620             


Asn Lys  Met Asp Glu Lys Tyr  Ser Ala His 
    1625                 1630             


<210>  38
<211>  1592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  38

Met Asp Lys Ser Ser Ile Gly Asp Lys Ile Glu Ala Tyr Leu Glu Lys 
1               5                   10                  15      


Lys Ser Asn Glu Ser Asp Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys Asn 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Ile Asp Glu Trp Lys 
65                  70                  75                  80  


Cys Gln Gln Asn Ser Ser Asp Gly Ser Gly Lys Pro Glu Asn Ile Cys 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
            100                 105                 110         


Lys Phe Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
                165                 170                 175     


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Leu Glu Lys 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Thr Lys 
        195                 200                 205             


Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
    210                 215                 220                 


Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Arg Trp 
225                 230                 235                 240 


Thr Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
                245                 250                 255     


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Tyr Leu Asp Tyr Val 
            260                 265                 270         


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Ala Asp Leu Tyr Arg 
        275                 280                 285             


Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His Arg Glu Glu Cys 
    290                 295                 300                 


Thr Arg Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Asn Met 
305                 310                 315                 320 


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
                325                 330                 335     


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Lys Asp Leu Tyr Glu Gln 
            340                 345                 350         


Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
        355                 360                 365             


Val Lys Glu Phe Phe Lys Lys Leu Glu Ala Asn Tyr Lys Ser Leu Asp 
    370                 375                 380                 


Asp Tyr Ile Lys Asp Asp Pro Tyr Ser Lys Glu Tyr Val Thr Lys Leu 
385                 390                 395                 400 


Ser Phe Ile Pro Asn Ser Ser Asp Thr Glu Asn Ala Ser Glu Lys Ile 
                405                 410                 415     


Gln Lys Asn Asn Asp Glu Val Cys Asn Pro Asn Glu Ser Gly Ile Ser 
            420                 425                 430         


Ser Val Gly Gln Ala Gln Thr Ser Gly Thr Ser Ser Asn Lys Thr Cys 
        435                 440                 445             


Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Val Cys Lys His 
    450                 455                 460                 


Val Lys Leu Gly Ile Asn Asn Asn Asp Lys Val Leu Arg Val Cys Val 
465                 470                 475                 480 


Ile Glu Asp Asp Ser Leu Arg Gly Val Asp Asn Cys Cys Cys Gln Asp 
                485                 490                 495     


Phe Leu Arg Met Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg Gly Ser 
            500                 505                 510         


Ser Ser Asn Asp Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
        515                 520                 525             


Asn Leu Asp Glu Ala Leu Ala Ser Leu Thr Asn Gly Tyr Lys Cys Asp 
    530                 535                 540                 


Lys Cys Lys Ser Gly Thr Ser Thr Val Asn Lys Asn Trp Ile Trp Arg 
545                 550                 555                 560 


Lys Ser Ser Gly Asn Lys Glu Gly Leu Gln Lys Glu Tyr Ala Asn Thr 
                565                 570                 575     


Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Cys Leu His 
            580                 585                 590         


Glu Lys Glu Gly Lys Thr Gln Glu Leu Lys Asn Ile Ser Thr Asn Ser 
        595                 600                 605             


Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly Lys Asn 
    610                 615                 620                 


Leu Lys Thr Thr Tyr Pro Gln Asn Lys Asn Ala Glu Asn Lys Lys Lys 
625                 630                 635                 640 


Leu Cys Lys Ala Leu Lys Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile 
                645                 650                 655     


Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu Leu 
            660                 665                 670         


Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys Lys 
        675                 680                 685             


Asn Asn Thr Ala Glu Gln His Thr Ser Tyr Ser Ser Leu Asp Glu Leu 
    690                 695                 700                 


Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Thr Ala Met 
705                 710                 715                 720 


Lys His Gly Ala Gly Met Asn Gly Thr Thr Cys Ser Ser Gly Ser Gly 
                725                 730                 735     


Asp Asn Gly Ser Ile Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu Ile 
            740                 745                 750         


Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe Cys Glu 
        755                 760                 765             


Gln Arg Gln Gly Lys Val Lys Asp Val Ile Thr Asn Cys Lys Ser Cys 
    770                 775                 780                 


Lys Glu Ser Gly Asp Thr Cys Lys Thr Glu Cys Lys Thr Lys Cys Lys 
785                 790                 795                 800 


Asp Glu Cys Glu Lys Tyr Lys Thr Phe Ile Glu Asp Cys Asn Gly Gly 
                805                 810                 815     


Gly Thr Gly Thr Ala Gly Ser Ser Trp Ser Lys Arg Trp Asp Gln Ile 
            820                 825                 830         


Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys 
        835                 840                 845             


Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Ser Thr Ala Glu 
    850                 855                 860                 


Ser Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile 
865                 870                 875                 880 


Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp 
                885                 890                 895     


Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr 
            900                 905                 910         


Tyr Thr Thr Thr Glu Asn Cys Asp Ile Gln Lys Lys Thr Pro Lys Ser 
        915                 920                 925             


Gln Ser Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly 
    930                 935                 940                 


Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Glu Cys Lys Ile Pro Thr 
945                 950                 955                 960 


Thr Glu Glu Ser Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp Ile 
                965                 970                 975     


Ser Asp Thr Ser Lys Lys Gln Lys Gly Ser Gly Ser Gly Lys Asp Asp 
            980                 985                 990         


Tyr Glu Leu Tyr Thr Tyr Asn Gly  Val Lys Glu Thr Lys  Leu Pro Lys 
        995                 1000                 1005             


Lys Leu  Asn Ser Thr Lys Leu  Asp Asp Lys Asp Val  Met Phe Phe 
    1010                 1015                 1020             


Asn Leu  Phe Glu Gln Trp Asn  Lys Glu Ile Gln Tyr  Gln Ile Glu 
    1025                 1030                 1035             


Gln Tyr  Met Thr Asn Ala Asn  Ile Ser Cys Asn Asn  Glu Met Asn 
    1040                 1045                 1050             


Val Leu  Ser Ser Ser Ser Glu  Glu Ser Gln Asn Gln  Lys Gly Ser 
    1055                 1060                 1065             


Asp His  His Val Gly Arg Asn  Asn Asn Thr Asp Gln  Gly Thr Asn 
    1070                 1075                 1080             


Cys Arg  Glu Lys Cys Glu Cys  Tyr Ser Leu Trp Ile  Glu Lys Ile 
    1085                 1090                 1095             


Lys Lys  Gln Trp Gly Lys Gln  Lys Asp Asn Tyr Asn  Lys Phe Gln 
    1100                 1105                 1110             


Arg Lys  Gln Ile Tyr Asp Gly  Asn Asn Ala Ser His  Lys Lys Glu 
    1115                 1120                 1125             


Ile Val  Lys Leu Ser Asn Phe  Leu Phe Phe Ser Cys  Trp Glu Glu 
    1130                 1135                 1140             


Tyr Ile  Gln Lys Tyr Phe Asn  Gly Asp Trp Ser Lys  Ile Lys Asn 
    1145                 1150                 1155             


Ile Gly  Ser Asp Thr Phe Glu  Phe Leu Ile Lys Lys  Cys Gly Asn 
    1160                 1165                 1170             


Asp Ser  Ala His Gly Glu Thr  Ile Phe Ser Glu Lys  Leu Lys Asn 
    1175                 1180                 1185             


Ala Gln  Gln Gln Cys Lys Glu  Ile Gln Asn Thr Asp  Thr Asn Ile 
    1190                 1195                 1200             


Asn Lys  Ser Gly Lys Ser Gly  Ser Gly Ser Gly Ala  Glu Lys Lys 
    1205                 1210                 1215             


Asn Asn  Lys Ser Leu Cys His  Glu Lys Gly Asn Asp  Arg Thr Trp 
    1220                 1225                 1230             


Ser Lys  Lys Tyr Ile Lys Lys  Leu Glu Asn Gly Arg  Ser Leu Glu 
    1235                 1240                 1245             


Gly Val  Tyr Val Pro Pro Arg  Arg Gln Gln Leu Cys  Leu Tyr Glu 
    1250                 1255                 1260             


Leu Phe  Pro Ile Ile Ile Lys  Lys Glu Lys Asp Met  Glu Asn Val 
    1265                 1270                 1275             


Lys Lys  Glu Leu Leu Glu Thr  Leu Gln Ile Val Ala  Glu Arg Glu 
    1280                 1285                 1290             


Ala Tyr  Tyr Leu Trp Lys Gln  Tyr Asn Pro Thr Gly  Lys Gly Ile 
    1295                 1300                 1305             


Asp Asp  Ala Asn Lys Lys Ala  Cys Cys Ala Ile Arg  Gly Ser Phe 
    1310                 1315                 1320             


Tyr Asp  Leu Glu Asp Ile Ile  Lys Gly Asn Asp Leu  Val His Asp 
    1325                 1330                 1335             


Glu Tyr  Thr Lys Tyr Ile Asp  Ser Lys Leu Asn Glu  Ile Phe Gly 
    1340                 1345                 1350             


Ser Ser  Asn Lys Asn Asp Ile  Asp Thr Lys Arg Ala  Arg Thr Asp 
    1355                 1360                 1365             


Trp Trp  Glu Asn Glu Thr Phe  Gln Val Ser Asn Ile  Thr Gly Ala 
    1370                 1375                 1380             


Asn Lys  Ser Asp Pro Lys Thr  Ile Arg Gln Leu Val  Trp Asp Ala 
    1385                 1390                 1395             


Met Gln  Ser Gly Val Arg Tyr  Ala Val Glu Glu Lys  Asn Glu Asn 
    1400                 1405                 1410             


Phe Pro  Pro Cys Met Gly Val  Glu His Ile Gly Ile  Ala Lys Pro 
    1415                 1420                 1425             


Gln Phe  Ile Arg Trp Leu Glu  Glu Trp Thr Asn Glu  Phe Cys Glu 
    1430                 1435                 1440             


Lys Tyr  Thr Lys Tyr Phe Glu  Asp Met Lys Ser Asn  Cys Asn Arg 
    1445                 1450                 1455             


Arg Lys  Gly Ala Asp Thr Cys  Gly Asp Asn Ser Asn  Ile Glu Cys 
    1460                 1465                 1470             


Lys Arg  Ala Cys Ala Asn Tyr  Thr Asn Trp Leu Asn  Pro Lys Arg 
    1475                 1480                 1485             


Ile Glu  Trp Asn Gly Met Ser  Asn Tyr Tyr Asn Lys  Ile Tyr Arg 
    1490                 1495                 1500             


Lys Ser  Asn Lys Glu Ser Glu  Asp Gly Lys Asp Tyr  Ser Met Ile 
    1505                 1510                 1515             


Met Glu  Pro Thr Val Ile Asp  Tyr Leu Asn Lys Arg  Cys His Gly 
    1520                 1525                 1530             


Glu Ile  Asn Gly Asn Tyr Ile  Cys Cys Ser Cys Lys  Asn Ile Gly 
    1535                 1540                 1545             


Glu Tyr  Asn Ser Thr Ser Gly  Thr Val Asn Lys Lys  Leu Gln Lys 
    1550                 1555                 1560             


Lys Glu  Thr Glu Cys Glu Glu  Glu Lys Gly Pro Leu  Asp Leu Met 
    1565                 1570                 1575             


Asn Glu  Val Leu Asn Lys Met  Asp Glu Lys Tyr Ser  Ala His 
    1580                 1585                 1590         


<210>  39
<211>  1615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  39

Met Asp Lys Ser Ser Ile Ala Asn Lys Ile Glu Glu Tyr Leu Lys Glu 
1               5                   10                  15      


Lys Ser Asp Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys Asn 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Glu Lys Lys Leu Leu Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Asp Glu Asn Leu Ser Lys Val Ser Gly Lys Pro Glu Asn Ile Cys 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
            100                 105                 110         


Lys Phe Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Lys Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Leu Ala Asp Ile Ile Arg Gly Arg Asp Gly Asn Lys Cys Glu Thr Lys 
                165                 170                 175     


Ser Pro Asn Asn Val Glu Glu Leu Ile Lys Lys Phe Phe Glu Lys Asn 
            180                 185                 190         


Tyr Arg Ser Asn Glu Glu Tyr Arg Lys Lys Tyr Pro Asn Asp Asp Glu 
        195                 200                 205             


Asn Tyr Lys Lys Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys 
    210                 215                 220                 


Val Trp Glu Val Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile 
225                 230                 235                 240 


Lys Arg Arg Trp Arg Thr Ser Lys Glu Ser Asn Gly Glu Asn Lys Leu 
                245                 250                 255     


Glu Leu Cys Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Lys 
            260                 265                 270         


Leu Asp Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu 
        275                 280                 285             


Asp Phe Tyr Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His 
    290                 295                 300                 


Arg Glu Glu Cys Thr Arg Glu Asp Asp Lys Cys Lys Glu Gly Thr Ser 
305                 310                 315                 320 


Tyr Cys Asn Met Cys Lys Glu Lys His Thr Lys Tyr Cys Glu Cys Val 
                325                 330                 335     


Lys Lys Trp Lys Thr Glu Trp Glu Asn Gln Glu Asn Lys Tyr Thr Glu 
            340                 345                 350         


Leu Tyr Glu Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg 
        355                 360                 365             


Tyr Asp Asp Asn Val Lys Glu Phe Phe Glu Lys Leu Lys Gly Asn Gly 
    370                 375                 380                 


Tyr Ser Ser Ala Asn Ser Tyr Val Lys Asn Asn Pro Tyr Ser Ser Glu 
385                 390                 395                 400 


Asp Gly Lys Leu Leu Lys Phe Asp Asn Thr Asn Ala Phe Lys Glu Ser 
                405                 410                 415     


Ile Thr Cys Asn Lys Asn Val Cys Ser Cys Ser Gly Asn Glu Lys Leu 
            420                 425                 430         


Ile Ile Ser Glu Gly Ser Leu Ser Ser Ser Ser Phe Gly Thr Ser Ser 
        435                 440                 445             


Ser Tyr Gln Ser Ser Ile Ile Thr Ser Lys Lys Arg Asn Glu Cys Ala 
    450                 455                 460                 


Gln Ile Lys Phe Ser Gly Asn Glu Asn Asn Met Asn Ile Lys Ile Cys 
465                 470                 475                 480 


Ser Thr Gln Asp Asn Asn Leu Leu Val Lys Leu Glu Asp Leu Leu Lys 
                485                 490                 495     


Gly Phe Cys Asp Thr Cys Asp Thr Gly Ile Gly Val Glu Val Val Ser 
            500                 505                 510         


Glu Asn Asn Cys Glu Glu Gln Tyr Lys Lys Leu Leu Pro Ser Leu Glu 
        515                 520                 525             


Lys Cys Thr Val Leu Asn Cys Asn Glu Cys Asn Lys Thr Val Phe Lys 
    530                 535                 540                 


Asn Leu Lys Lys Gln Gln Glu Lys Trp Ile Trp Gly Lys Pro Lys Gln 
545                 550                 555                 560 


Glu Ala Ala Gly Leu Gln Glu Glu Tyr Ala Asn Thr Ile Gly Leu Pro 
                565                 570                 575     


Pro Arg Thr Gln Leu Leu Tyr Leu Val Cys Leu His Glu Lys Glu Gly 
            580                 585                 590         


Lys Thr Gln Glu Leu Lys Asn Ile Ser Thr Asn Ser Glu Leu Leu Lys 
        595                 600                 605             


Glu Trp Ile Ile Ala Ala Phe His Glu Gly Lys Asn Leu Lys Pro Ser 
    610                 615                 620                 


His Gln Asn Lys Asn Asp Asp Asn Gly Lys Lys Leu Cys Lys Asp Leu 
625                 630                 635                 640 


Lys Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile 
                645                 650                 655     


Trp Asp Asn Asp Phe Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ile 
            660                 665                 670         


Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys Lys Asn Ile Ser Thr Glu 
        675                 680                 685             


Gln Asp Thr Leu Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp 
    690                 695                 700                 


Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala Met Lys His Gly Ala Gly 
705                 710                 715                 720 


Met Asn Ser Thr Thr Cys Asn Gly Asp Gly Ser Val Thr Gly Ser Ser 
                725                 730                 735     


Asp Ser Gly Ser Thr Thr Cys Ser Gly Asp Asn Gly Ser Ile Ser Cys 
            740                 745                 750         


Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu 
        755                 760                 765             


Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg Gln Glu Lys Val Asn 
    770                 775                 780                 


Ala Val Ile Thr Asn Cys Lys Ser Cys Lys Asn Thr Ser Gly Glu Arg 
785                 790                 795                 800 


Lys Ile Gly Asp Thr Cys Gly Asn Asp Cys Glu Lys Lys Cys Lys Val 
                805                 810                 815     


Ala Cys Asp Ala Tyr Lys Glu Phe Ile Glu Glu Cys Arg Thr Ala Ala 
            820                 825                 830         


Glu Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln Ile Tyr 
        835                 840                 845             


Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala 
    850                 855                 860                 


Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala Glu Ser 
865                 870                 875                 880 


Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp 
                885                 890                 895     


Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp Glu 
            900                 905                 910         


Asn Asn Cys Gly Glu Asp Asn Ala Pro Trp Thr Thr Tyr Thr Thr Tyr 
        915                 920                 925             


Thr Thr Thr Lys Asn Cys Asp Ile Gln Lys Asp Lys Ser Lys Ser Gln 
    930                 935                 940                 


Ser Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
945                 950                 955                 960 


Thr Pro His Gly Tyr Lys Tyr Ala Cys Glu Cys Arg Thr Pro Asn Lys 
                965                 970                 975     


Gln Glu Thr Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp Ile Ile 
            980                 985                 990         


Asp Asn Thr Lys Asn Pro Lys Gly  Ser Gly Ser Gly Lys  Asp Tyr Tyr 
        995                 1000                 1005             


Glu Leu  Cys Lys Tyr Asn Gly  Val Lys Glu Thr Lys  Leu Pro Lys 
    1010                 1015                 1020             


Lys Leu  Asn Ser Ser Lys Leu  Asp Asp Lys Asp Val  Met Phe Phe 
    1025                 1030                 1035             


Asn Leu  Phe Glu Gln Trp Asn  Lys Glu Ile Gln Tyr  Gln Ile Glu 
    1040                 1045                 1050             


Gln Tyr  Met Thr Tyr Ala Asn  Ile Ser Cys Asn Asn  Glu Met Asn 
    1055                 1060                 1065             


Val Leu  Ser Ser Ser Ser Glu  Glu Ser Gln Asn Gln  Asn Gly Ser 
    1070                 1075                 1080             


Asp His  His Asp Gly Arg Asn  Asn Asn Thr Asp Gln  Gly Thr Asn 
    1085                 1090                 1095             


Cys Arg  Glu Lys Cys Lys Cys  Tyr Ser Leu Trp Ile  Glu Lys Ile 
    1100                 1105                 1110             


Lys Lys  Gln Trp Gly Lys Gln  Lys Asn Asn Tyr Asn  Lys Phe Glu 
    1115                 1120                 1125             


Lys Lys  Thr Ser Ser Tyr Ala  Asn Lys Gly Pro Gln  Asn Lys Lys 
    1130                 1135                 1140             


Val Val  Ser Leu Ser His Phe  Leu Phe Phe Ser Cys  Trp Glu Glu 
    1145                 1150                 1155             


Tyr Ile  Gln Lys Tyr Phe Asn  Gly Asp Trp Ser Lys  Ile Lys Asn 
    1160                 1165                 1170             


Ile Gly  Ser Asp Thr Phe Glu  Phe Leu Ile Lys Lys  Cys Gly Asn 
    1175                 1180                 1185             


Asp Ser  Ala His Gly Glu Thr  Ile Phe Ser Glu Lys  Leu Asn Asn 
    1190                 1195                 1200             


Ala His  Ile Lys Cys Asn Glu  Asn Ala Ser Lys Asn  Thr Lys Ile 
    1205                 1210                 1215             


Asn Pro  Ser Val Ile Ser Ser  Asp Gly Ser Gly Ser  Gly Asp Lys 
    1220                 1225                 1230             


Gly Gln  Asn Asn Lys Ser Leu  Cys His Glu Lys Gly  Asn Asp Arg 
    1235                 1240                 1245             


Thr Trp  Ser Lys Lys Tyr Ile  Lys Lys Leu Glu Asn  Gly Arg Ser 
    1250                 1255                 1260             


Leu Glu  Gly Val Tyr Val Pro  Pro Gly Arg Gln Gln  Leu Cys Leu 
    1265                 1270                 1275             


Tyr Glu  Leu Phe Pro Ile Ile  Ile Lys Asn Glu Glu  Gly Met Glu 
    1280                 1285                 1290             


Lys Ala  Lys Lys Glu Leu Leu  Glu Thr Leu Gln Ile  Val Ala Glu 
    1295                 1300                 1305             


Arg Glu  Ala Tyr Tyr Leu Trp  Lys Gln Tyr His Ala  His Asn Asp 
    1310                 1315                 1320             


Thr Thr  Tyr Leu Ala His Lys  Lys Ala Cys Cys Ala  Ile Arg Gly 
    1325                 1330                 1335             


Ser Phe  Tyr Asp Leu Glu Asp  Ile Ile Lys Gly Asn  Asp Leu Val 
    1340                 1345                 1350             


His Asp  Glu Tyr Thr Lys Tyr  Ile Asp Ser Lys Leu  Asn Lys Ile 
    1355                 1360                 1365             


Phe Gly  Ser Ser Asn Thr Asn  Asn Ile Glu Thr Lys  Arg Ala Arg 
    1370                 1375                 1380             


Thr Asp  Trp Trp Glu Asn Lys  Thr Ile Asp Val Pro  Asn Ile Thr 
    1385                 1390                 1395             


Asp Ala  Asn Lys Ser Asp Ser  Lys Thr Ile Arg Gln  Leu Val Trp 
    1400                 1405                 1410             


Asp Ala  Met Gln Ser Gly Val  Arg Lys Ala Ile Asp  Glu Glu Asn 
    1415                 1420                 1425             


Glu Lys  Lys Lys Pro Asn Glu  Asn Phe Pro Pro Cys  Met Gly Val 
    1430                 1435                 1440             


Glu His  Ile Gly Ile Ala Lys  Pro Gln Phe Ile Arg  Trp Leu Glu 
    1445                 1450                 1455             


Glu Trp  Thr Asn Glu Phe Cys  Glu Lys Tyr Thr Lys  Tyr Phe Glu 
    1460                 1465                 1470             


Asp Met  Lys Ser Asn Cys Asp  Pro Pro Lys Ser Ala  Asp Asp Cys 
    1475                 1480                 1485             


Gly Asp  Asn Thr Asn Ile Glu  Cys Lys Lys Ala Cys  Ala Asn Tyr 
    1490                 1495                 1500             


Thr Asn  Trp Leu Asn Pro Lys  Arg Ile Glu Trp Asn  Gly Met Ser 
    1505                 1510                 1515             


Asn Tyr  Tyr Asn Lys Ile Tyr  Arg Lys Ser Asn Lys  Glu Ser Glu 
    1520                 1525                 1530             


Asp Gly  Lys Asp Tyr Ser Met  Ile Met Glu Pro Thr  Val Ile Asp 
    1535                 1540                 1545             


Tyr Leu  Asn Lys Arg Cys His  Gly Glu Ile Asn Gly  Asn Tyr Ile 
    1550                 1555                 1560             


Cys Cys  Ser Cys Lys Asn Ile  Gly Ala Tyr Asn Thr  Thr Ser Gly 
    1565                 1570                 1575             


Thr Val  Asn Lys Lys Leu Gln  Lys Lys Glu Thr Glu  Cys Glu Asp 
    1580                 1585                 1590             


Asn Lys  Gly Pro Leu Asp Leu  Met Asn Glu Val Leu  Asn Lys Met 
    1595                 1600                 1605             


Asp Pro  Lys Tyr Ser Lys Leu  
    1610                 1615 


<210>  40
<211>  1995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  40

Met Asp Lys Ser Ser Ile Ala Asn Lys Ile Glu Glu Tyr Leu Lys Glu 
1               5                   10                  15      


Lys Ser Asp Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys Asn 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Glu Lys Lys Leu Leu Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Asp Glu Asn Leu Ser Lys Val Ser Gly Lys Pro Glu Asn Ile Cys 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
            100                 105                 110         


Lys Phe Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Lys Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Leu Ala Asp Ile Ile Arg Gly Arg Asp Gly Asn Lys Cys Glu Thr Lys 
                165                 170                 175     


Ser Pro Asn Asn Val Glu Glu Leu Ile Lys Lys Phe Phe Glu Lys Asn 
            180                 185                 190         


Tyr Arg Ser Asn Glu Glu Tyr Arg Lys Lys Tyr Pro Asn Asp Asp Glu 
        195                 200                 205             


Asn Tyr Lys Lys Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys 
    210                 215                 220                 


Val Trp Glu Val Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile 
225                 230                 235                 240 


Lys Arg Arg Trp Arg Thr Ser Lys Glu Ser Asn Gly Glu Asn Lys Leu 
                245                 250                 255     


Glu Leu Cys Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Lys 
            260                 265                 270         


Leu Asp Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu 
        275                 280                 285             


Asp Phe Tyr Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His 
    290                 295                 300                 


Arg Glu Glu Cys Thr Arg Glu Asp Asp Lys Cys Lys Glu Gly Thr Ser 
305                 310                 315                 320 


Tyr Cys Asn Met Cys Lys Glu Lys His Thr Lys Tyr Cys Glu Cys Val 
                325                 330                 335     


Lys Lys Trp Lys Thr Glu Trp Glu Asn Gln Glu Asn Lys Tyr Thr Glu 
            340                 345                 350         


Leu Tyr Glu Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg 
        355                 360                 365             


Tyr Asp Asp Asn Val Lys Glu Phe Phe Glu Lys Leu Lys Gly Asn Gly 
    370                 375                 380                 


Tyr Ser Ser Ala Asn Ser Tyr Val Lys Asn Asn Pro Tyr Ser Ser Glu 
385                 390                 395                 400 


Asp Gly Lys Leu Leu Lys Phe Asp Asn Thr Asn Ala Phe Lys Glu Ser 
                405                 410                 415     


Ile Thr Cys Asn Lys Asn Val Cys Ser Cys Ser Gly Asn Glu Lys Leu 
            420                 425                 430         


Ile Ile Ser Glu Gly Ser Leu Ser Ser Ser Ser Phe Gly Thr Ser Ser 
        435                 440                 445             


Ser Tyr Gln Ser Ser Ile Ile Thr Ser Lys Lys Arg Asn Glu Cys Ala 
    450                 455                 460                 


Gln Ile Lys Phe Ser Gly Asn Glu Asn Asn Met Asn Ile Lys Ile Cys 
465                 470                 475                 480 


Ser Thr Gln Asp Asn Asn Leu Leu Val Lys Leu Glu Asp Leu Leu Lys 
                485                 490                 495     


Gly Phe Cys Asp Thr Cys Asp Thr Gly Ile Gly Val Glu Val Val Ser 
            500                 505                 510         


Glu Asn Asn Cys Glu Glu Gln Tyr Lys Lys Leu Leu Pro Ser Leu Glu 
        515                 520                 525             


Lys Cys Thr Val Leu Asn Cys Asn Glu Cys Asn Lys Thr Val Phe Lys 
    530                 535                 540                 


Asn Leu Lys Lys Gln Gln Glu Lys Trp Ile Trp Gly Lys Pro Lys Gln 
545                 550                 555                 560 


Glu Ala Ala Gly Leu Gln Glu Glu Tyr Ala Asn Thr Ile Gly Leu Pro 
                565                 570                 575     


Pro Arg Thr Gln Leu Leu Tyr Leu Val Cys Leu His Glu Lys Glu Gly 
            580                 585                 590         


Lys Thr Gln Glu Leu Lys Asn Ile Ser Thr Asn Ser Glu Leu Leu Lys 
        595                 600                 605             


Glu Trp Ile Ile Ala Ala Phe His Glu Gly Lys Asn Leu Lys Pro Ser 
    610                 615                 620                 


His Gln Asn Lys Asn Asp Asp Asn Gly Lys Lys Leu Cys Lys Asp Leu 
625                 630                 635                 640 


Lys Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile 
                645                 650                 655     


Trp Asp Asn Asp Phe Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ile 
            660                 665                 670         


Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys Lys Asn Ile Ser Thr Glu 
        675                 680                 685             


Gln Asp Thr Leu Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp 
    690                 695                 700                 


Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala Met Lys His Gly Ala Gly 
705                 710                 715                 720 


Met Asn Ser Thr Thr Cys Asn Gly Asp Gly Ser Val Thr Gly Ser Ser 
                725                 730                 735     


Asp Ser Gly Ser Thr Thr Cys Ser Gly Asp Asn Gly Ser Ile Ser Cys 
            740                 745                 750         


Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu 
        755                 760                 765             


Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg Gln Glu Lys Val Asn 
    770                 775                 780                 


Ala Val Ile Thr Asn Cys Lys Ser Cys Lys Asn Thr Ser Gly Glu Arg 
785                 790                 795                 800 


Lys Ile Gly Asp Thr Cys Gly Asn Asp Cys Glu Lys Lys Cys Lys Val 
                805                 810                 815     


Ala Cys Asp Ala Tyr Lys Glu Phe Ile Glu Glu Cys Arg Thr Ala Ala 
            820                 825                 830         


Glu Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln Ile Tyr 
        835                 840                 845             


Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala 
    850                 855                 860                 


Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala Glu Ser 
865                 870                 875                 880 


Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp 
                885                 890                 895     


Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp Glu 
            900                 905                 910         


Asn Asn Cys Gly Glu Asp Asn Ala Pro Trp Thr Thr Tyr Thr Thr Tyr 
        915                 920                 925             


Thr Thr Thr Lys Asn Cys Asp Ile Gln Lys Asp Lys Ser Lys Ser Gln 
    930                 935                 940                 


Ser Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
945                 950                 955                 960 


Thr Pro His Gly Tyr Lys Tyr Ala Cys Glu Cys Arg Thr Pro Asn Lys 
                965                 970                 975     


Gln Glu Thr Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp Ile Ile 
            980                 985                 990         


Asp Asn Thr Lys Asn Pro Lys Gly  Ser Gly Ser Gly Lys  Asp Tyr Tyr 
        995                 1000                 1005             


Glu Leu  Cys Lys Tyr Asn Gly  Val Lys Glu Thr Lys  Leu Pro Lys 
    1010                 1015                 1020             


Lys Leu  Asn Ser Ser Lys Leu  Asp Asp Lys Asp Val  Met Phe Phe 
    1025                 1030                 1035             


Asn Leu  Phe Glu Gln Trp Asn  Lys Glu Ile Gln Tyr  Gln Ile Glu 
    1040                 1045                 1050             


Gln Tyr  Met Thr Tyr Ala Asn  Ile Ser Cys Asn Asn  Glu Met Asn 
    1055                 1060                 1065             


Val Leu  Ser Ser Ser Ser Glu  Glu Ser Gln Asn Gln  Asn Gly Ser 
    1070                 1075                 1080             


Asp His  His Asp Gly Arg Asn  Asn Asn Thr Asp Gln  Gly Thr Asn 
    1085                 1090                 1095             


Cys Arg  Glu Lys Cys Lys Cys  Tyr Ser Leu Trp Ile  Glu Lys Ile 
    1100                 1105                 1110             


Lys Lys  Gln Trp Gly Lys Gln  Lys Asn Asn Tyr Asn  Lys Phe Glu 
    1115                 1120                 1125             


Lys Lys  Thr Ser Ser Tyr Ala  Asn Lys Gly Pro Gln  Asn Lys Lys 
    1130                 1135                 1140             


Val Val  Ser Leu Ser His Phe  Leu Phe Phe Ser Cys  Trp Glu Glu 
    1145                 1150                 1155             


Tyr Ile  Gln Lys Tyr Phe Asn  Gly Asp Trp Ser Lys  Ile Lys Asn 
    1160                 1165                 1170             


Ile Gly  Ser Asp Thr Phe Glu  Phe Leu Ile Lys Lys  Cys Gly Asn 
    1175                 1180                 1185             


Asp Ser  Ala His Gly Glu Thr  Ile Phe Ser Glu Lys  Leu Asn Asn 
    1190                 1195                 1200             


Ala His  Ile Lys Cys Asn Glu  Asn Ala Ser Lys Asn  Thr Lys Ile 
    1205                 1210                 1215             


Asn Pro  Ser Val Ile Ser Ser  Asp Gly Ser Gly Ser  Gly Asp Lys 
    1220                 1225                 1230             


Gly Gln  Asn Asn Lys Ser Leu  Cys His Glu Lys Gly  Asn Asp Arg 
    1235                 1240                 1245             


Thr Trp  Ser Lys Lys Tyr Ile  Lys Lys Leu Glu Asn  Gly Arg Ser 
    1250                 1255                 1260             


Leu Glu  Gly Val Tyr Val Pro  Pro Gly Arg Gln Gln  Leu Cys Leu 
    1265                 1270                 1275             


Tyr Glu  Leu Phe Pro Ile Ile  Ile Lys Asn Glu Glu  Gly Met Glu 
    1280                 1285                 1290             


Lys Ala  Lys Lys Glu Leu Leu  Glu Thr Leu Gln Ile  Val Ala Glu 
    1295                 1300                 1305             


Arg Glu  Ala Tyr Tyr Leu Trp  Lys Gln Tyr His Ala  His Asn Asp 
    1310                 1315                 1320             


Thr Thr  Tyr Leu Ala His Lys  Lys Ala Cys Cys Ala  Ile Arg Gly 
    1325                 1330                 1335             


Ser Phe  Tyr Asp Leu Glu Asp  Ile Ile Lys Gly Asn  Asp Leu Val 
    1340                 1345                 1350             


His Asp  Glu Tyr Thr Lys Tyr  Ile Asp Ser Lys Leu  Asn Lys Ile 
    1355                 1360                 1365             


Phe Gly  Ser Ser Asn Thr Asn  Asn Ile Glu Thr Lys  Arg Ala Arg 
    1370                 1375                 1380             


Thr Asp  Trp Trp Glu Asn Lys  Thr Ile Asp Val Pro  Asn Ile Thr 
    1385                 1390                 1395             


Asp Ala  Asn Lys Ser Asp Ser  Lys Thr Ile Arg Gln  Leu Val Trp 
    1400                 1405                 1410             


Asp Ala  Met Gln Ser Gly Val  Arg Lys Ala Ile Asp  Glu Glu Asn 
    1415                 1420                 1425             


Glu Lys  Lys Lys Pro Asn Glu  Asn Phe Pro Pro Cys  Met Gly Val 
    1430                 1435                 1440             


Glu His  Ile Gly Ile Ala Lys  Pro Gln Phe Ile Arg  Trp Leu Glu 
    1445                 1450                 1455             


Glu Trp  Thr Asn Glu Phe Cys  Glu Lys Tyr Thr Lys  Tyr Phe Glu 
    1460                 1465                 1470             


Asp Met  Lys Ser Asn Cys Asp  Pro Pro Lys Ser Ala  Asp Asp Cys 
    1475                 1480                 1485             


Gly Asp  Asn Thr Asn Ile Glu  Cys Lys Lys Ala Cys  Ala Asn Tyr 
    1490                 1495                 1500             


Thr Asn  Trp Leu Asn Pro Lys  Arg Ile Glu Trp Asn  Gly Met Ser 
    1505                 1510                 1515             


Asn Tyr  Tyr Asn Lys Ile Tyr  Arg Lys Ser Asn Lys  Glu Ser Glu 
    1520                 1525                 1530             


Asp Gly  Lys Asp Tyr Ser Met  Ile Met Glu Pro Thr  Val Ile Asp 
    1535                 1540                 1545             


Tyr Leu  Asn Lys Arg Cys His  Gly Glu Ile Asn Gly  Asn Tyr Ile 
    1550                 1555                 1560             


Cys Cys  Ser Cys Lys Asn Ile  Gly Ala Tyr Asn Thr  Thr Ser Gly 
    1565                 1570                 1575             


Thr Val  Asn Lys Lys Leu Gln  Lys Lys Glu Thr Glu  Cys Glu Asp 
    1580                 1585                 1590             


Asn Lys  Gly Pro Leu Asp Leu  Met Asn Glu Val Leu  Asn Lys Met 
    1595                 1600                 1605             


Asp Pro  Lys Tyr Ser Lys Leu  Gly Ser Gly Ser Gly  Asp Lys Gly 
    1610                 1615                 1620             


Gln Asn  Asn Lys Ser Leu Cys  His Glu Lys Gly Asn  Asp Arg Thr 
    1625                 1630                 1635             


Trp Ser  Lys Lys Tyr Ile Lys  Lys Leu Glu Asn Gly  Arg Thr Leu 
    1640                 1645                 1650             


Glu Gly  Val Tyr Val Pro Pro  Arg Arg Gln Gln Leu  Cys Leu Tyr 
    1655                 1660                 1665             


Glu Leu  Phe Pro Ile Ile Ile  Lys Lys Glu Asn Asp  Ile Thr Asn 
    1670                 1675                 1680             


Ala Lys  Lys Glu Leu Leu Glu  Thr Leu Gln Ile Val  Ala Glu Arg 
    1685                 1690                 1695             


Glu Ala  Tyr Tyr Leu Trp Lys  Gln Tyr Asn Pro Thr  Gly Lys Gly 
    1700                 1705                 1710             


Ile Asp  Asp Ala Asn Lys Lys  Ala His Lys Lys Ala  Cys Cys Ala 
    1715                 1720                 1725             


Ile Arg  Gly Ser Phe Tyr Asp  Leu Glu Asp Ile Ile  Lys Gly Asn 
    1730                 1735                 1740             


Asp Leu  Val His Asp Glu Tyr  Thr Lys Tyr Ile Asp  Ser Lys Leu 
    1745                 1750                 1755             


Asn Lys  Ile Phe Gly Ser Ser  Asn Thr Asn Asn Ile  Asp Thr Lys 
    1760                 1765                 1770             


Arg Ala  Arg Thr Asp Trp Trp  Glu Asn Glu Ile Ile  Thr Asn Gly 
    1775                 1780                 1785             


Thr Asp  Ser Lys Thr Ile Arg  Gln Leu Val Trp Asp  Ala Met Gln 
    1790                 1795                 1800             


Ser Gly  Val Arg Tyr Ala Val  Glu Glu Lys Asn Glu  Asn Phe Pro 
    1805                 1810                 1815             


Pro Cys  Met Gly Val Glu His  Ile Gly Ile Ala Lys  Pro Gln Phe 
    1820                 1825                 1830             


Ile Arg  Trp Leu Glu Glu Trp  Thr Asn Glu Phe Cys  Glu Lys Tyr 
    1835                 1840                 1845             


Thr Lys  Tyr Phe Glu Asp Met  Lys Ser Lys Cys Asp  Pro Pro Lys 
    1850                 1855                 1860             


Ser Ala  Asp Asp Cys Gly Asp  Asn Ser Asn Ile Glu  Cys Lys Arg 
    1865                 1870                 1875             


Ala Cys  Ala Asn Tyr Thr Asn  Trp Leu Asn Pro Lys  Arg Ile Glu 
    1880                 1885                 1890             


Trp Asn  Gly Met Ser Asn Tyr  Tyr Asn Lys Ile Tyr  Arg Lys Ser 
    1895                 1900                 1905             


Asn Lys  Glu Ser Glu Asp Gly  Lys Asp Tyr Ser Met  Ile Met Glu 
    1910                 1915                 1920             


Pro Thr  Val Ile Asp Tyr Leu  Asn Lys Arg Cys Asn  Gly Glu Ile 
    1925                 1930                 1935             


Asn Gly  Asn Tyr Ile Cys Cys  Ser Cys Lys Asn Ile  Gly Glu Asn 
    1940                 1945                 1950             


Ser Thr  Ser Pro Ala Gln Lys  Thr Lys Gly Ser Lys  Lys Lys Asp 
    1955                 1960                 1965             


Glu Gln  Cys Glu Asp Asn Lys  Gly Pro Leu Asp Leu  Met Asn Glu 
    1970                 1975                 1980             


Val Leu  Asn Lys Met Asp Glu  Lys Tyr Ser Glu His  
    1985                 1990                 1995 


<210>  41
<211>  1601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  41

Met Asp Ser Thr Ser Thr Ile Gly Asp Lys Ile Glu Glu Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asn Glu Ser Asn Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Lys Val Gln Tyr Tyr Arg Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn 
    50                  55                  60                  


Asp Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Asn Asn Lys Asn Ile 
                85                  90                  95      


Phe Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Asn 
            100                 105                 110         


Leu Lys Phe Glu Arg Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Lys Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Lys Lys Ile Leu Glu 
            180                 185                 190         


Lys Asp Ser Thr Leu Lys Asn Asn Tyr Ser Asn Asp Asp Glu Asn Tyr 
        195                 200                 205             


Lys Lys Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys Val Trp 
    210                 215                 220                 


Glu Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg 
225                 230                 235                 240 


Arg Trp Thr Thr Ser Lys Glu Ser Asn Gly Glu Asn Lys Leu Glu Leu 
                245                 250                 255     


Cys Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp 
            260                 265                 270         


Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Leu 
        275                 280                 285             


Tyr Arg Glu Glu Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu 
    290                 295                 300                 


Glu Cys Thr Ser Glu Asp Asp Lys Ser Asn Glu Gly Thr Ser Tyr Cys 
305                 310                 315                 320 


Thr Asn Cys Lys Glu Lys His Thr Lys Tyr Cys Glu Cys Val Lys Lys 
                325                 330                 335     


Trp Lys Thr Glu Trp Glu Asn Gln Lys Asn Lys Tyr Asn Asp Leu Tyr 
            340                 345                 350         


Gln Gln Lys Lys Asn Glu Thr Ser Ser Ser Ser Lys Lys Lys Ser Arg 
        355                 360                 365             


Tyr Asp Asp Tyr Val Lys Asp Phe Phe Lys Lys Leu Lys Gly Asn Val 
    370                 375                 380                 


Tyr Ser Ser Ala Asn Ser Tyr Val Lys Asn Asp Pro Tyr Ser Lys Glu 
385                 390                 395                 400 


Tyr Val Thr Lys Leu Ser Phe Ile Leu Asn Pro Ser Asp Ala Asn Thr 
                405                 410                 415     


Ser Ser Gly Glu Thr Ala Asn His Asn Asp Glu Val Cys Asn Cys Asn 
            420                 425                 430         


Glu Ser Gly Ile Ala Cys Val Gly Gln Ala Gln Ile Ser Asp Arg Leu 
        435                 440                 445             


Ser Gln Lys Ala Cys Asn Thr His Ser Ser Ile Lys Thr Asn Lys Lys 
    450                 455                 460                 


Lys Glu Cys Lys His Val Lys Leu Gly Val Arg Glu Asn Asp Lys Val 
465                 470                 475                 480 


Leu Lys Ile Cys Val Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn 
                485                 490                 495     


Cys Cys Cys Gln Asp Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp 
            500                 505                 510         


Asn Ile Arg Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln 
        515                 520                 525             


Asp Glu Cys Glu Lys Asn Leu Asp Glu Ala Leu Ala Ser Leu Thr Asn 
    530                 535                 540                 


Cys Tyr Lys Cys Glu Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn 
545                 550                 555                 560 


Lys Asn Trp Ile Trp Lys Lys Tyr Ser Val Lys Glu Glu Gly Leu Gln 
                565                 570                 575     


Lys Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu 
            580                 585                 590         


Tyr Leu Gly Asn Leu Arg Lys Leu Glu Asn Val Cys Lys Asp Val Thr 
        595                 600                 605             


Asp Ile Asn Phe Asp Thr Lys Glu Lys Phe Leu Ala Gly Cys Leu Ile 
    610                 615                 620                 


Ala Ala Phe His Glu Gly Lys Asn Leu Lys Thr Thr Tyr Leu Glu Lys 
625                 630                 635                 640 


Lys Asn Asp Asp Asn Gly Lys Lys Leu Cys Lys Ala Leu Lys Tyr Ser 
                645                 650                 655     


Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn 
            660                 665                 670         


Asp Phe Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ala Phe Gly Lys 
        675                 680                 685             


Leu Phe Arg Lys Tyr Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr 
    690                 695                 700                 


Ser Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn 
705                 710                 715                 720 


Lys Lys Tyr Ile Trp Thr Ala Met Lys His Gly Thr Thr Cys Ser Ser 
                725                 730                 735     


Gly Ser Gly Asp Asn Gly Ser Ile Ser Cys Asp Asp Met Pro Thr Ile 
            740                 745                 750         


Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His 
        755                 760                 765             


Phe Cys Lys Gln Arg Gln Glu Lys Val Asn Ala Val Ile Thr Asn Cys 
    770                 775                 780                 


Lys Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr 
785                 790                 795                 800 


Glu Cys Glu Lys Lys Cys Lys Thr Lys Cys Lys Asp Glu Cys Asp Ala 
                805                 810                 815     


Tyr Lys Asn Phe Ile Glu Asn Cys Lys Gly Gly Asp Gly Thr Ala Gly 
            820                 825                 830         


Ser Pro Trp Ser Lys Arg Trp Asp Gln Ile Tyr Met Arg Tyr Ser Lys 
        835                 840                 845             


Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys 
    850                 855                 860                 


Gly Thr Ser Ala Ala Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser 
865                 870                 875                 880 


Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr 
                885                 890                 895     


Leu Ser Ile Val Leu Asp Glu Asn Ile Cys Gly Asp Asp Asn Ala Pro 
            900                 905                 910         


Trp Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys 
        915                 920                 925             


Ser Lys Ser Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser 
    930                 935                 940                 


Pro Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Val Cys Glu Cys Arg 
945                 950                 955                 960 


Thr Pro Ser Asn Glu Glu Thr Cys Asp Asp Arg Lys Glu Tyr Met Asn 
                965                 970                 975     


Gln Trp Ile Ser Asp Thr Ser Lys Asn Pro Lys Gly Ser Gly Ser Gly 
            980                 985                 990         


Lys Asp Tyr Tyr Glu Leu Cys Lys  Tyr Asn Gly Val Lys  Glu Thr Lys 
        995                 1000                 1005             


Leu Pro  Lys Lys Ser Ser Ser  Thr Lys Leu Asp Glu  Asn Asp Val 
    1010                 1015                 1020             


Met Phe  Phe Asn Leu Phe Glu  Gln Trp Asn Lys Glu  Ile Gln Tyr 
    1025                 1030                 1035             


Gln Ile  Glu Gln Tyr Met Thr  Asn Thr Lys Ile Ser  Cys Asn Asn 
    1040                 1045                 1050             


Glu Met  Lys Val Leu Ser Arg  Val Ser Glu Glu Ser  Lys Asn Gln 
    1055                 1060                 1065             


Asn Ser  Ser Asp Asn His Asp  Gly Gly Asn Asn Asn  Thr Asp Gln 
    1070                 1075                 1080             


Gly Thr  Asn Cys Lys Glu Lys  Cys Glu Cys Tyr Glu  Leu Trp Ile 
    1085                 1090                 1095             


Glu Lys  Ile Lys Lys Gln Trp  Glu Thr Gln Lys Lys  Asn Tyr Asn 
    1100                 1105                 1110             


Asn Phe  Glu Thr Lys Gln Ser  Asn Asp Ala Arg Lys  Ser Ser Gln 
    1115                 1120                 1125             


Asn Lys  Lys Glu Ile Val Lys  Leu Ser His Phe Leu  Phe Phe Ser 
    1130                 1135                 1140             


Cys Trp  Glu Glu Tyr Ile Gln  Lys Tyr Phe Asn Gly  Asp Trp Ser 
    1145                 1150                 1155             


Lys Ile  Lys Asn Ile Gly Ser  Asp Thr Phe Glu Phe  Leu Ile Lys 
    1160                 1165                 1170             


Lys Cys  Gly Asn Asn Ser Gly  Asp Gly Glu Thr Ile  Phe Ser Glu 
    1175                 1180                 1185             


Lys Leu  Asn Asn Ala Gln Gln  Gln Cys Lys Glu Ile  Gln Asn Thr 
    1190                 1195                 1200             


Asp Thr  Lys Ile Asn Lys Ser  Glu Thr Ser Gly Ser  Gly Ser Gly 
    1205                 1210                 1215             


Ala Glu  Lys Lys Asn Asn Lys  Ser Leu Cys His Glu  Lys Gly Asn 
    1220                 1225                 1230             


Asp Arg  Thr Trp Ser Lys Lys  Tyr Ile Lys Lys Leu  Glu Asn Gly 
    1235                 1240                 1245             


Arg Thr  Leu Glu Gly Val Tyr  Val Pro Pro Arg Arg  Gln Gln Leu 
    1250                 1255                 1260             


Cys Leu  Tyr Glu Leu Phe Pro  Ile Ile Ile Lys Lys  Glu Lys Asp 
    1265                 1270                 1275             


Met Glu  Lys Ala Lys Glu Glu  Leu Leu Glu Thr Leu  Gln Ile Val 
    1280                 1285                 1290             


Ala Glu  Arg Glu Ala Tyr Tyr  Leu Trp Lys Gln Tyr  Asn Pro Thr 
    1295                 1300                 1305             


Gly Lys  Gly Ile Asp Asp Ala  Asn Lys Lys Ala Cys  Cys Ala Ile 
    1310                 1315                 1320             


Arg Gly  Ser Phe Tyr Asp Leu  Glu Asp Ile Ile Lys  Gly Asn Asp 
    1325                 1330                 1335             


Leu Val  His Asp Glu Tyr Thr  Lys Tyr Ile Asp Ser  Lys Leu Asn 
    1340                 1345                 1350             


Lys Ile  Phe Gly Ser Ser Asn  Thr Asn Asn Ile Asp  Thr Lys Arg 
    1355                 1360                 1365             


Ala Arg  Thr Asp Trp Trp Glu  Asn Lys Thr Ile Asp  Val Pro Lys 
    1370                 1375                 1380             


Ile Asp  Val Ala Asn Gly Thr  Asp Ser Lys Thr Ile  Arg Gln Leu 
    1385                 1390                 1395             


Val Trp  Asp Ala Met Gln Ser  Gly Val Arg Tyr Ala  Val Glu Lys 
    1400                 1405                 1410             


Asn Glu  Lys Lys Lys Gln Asn  Glu Asn Phe Pro Pro  Cys Met Arg 
    1415                 1420                 1425             


Val Gln  His Ile Gly Ile Ala  Lys Pro Gln Phe Ile  Arg Trp Leu 
    1430                 1435                 1440             


Glu Glu  Trp Thr Asn Glu Phe  Cys Glu Lys Tyr Thr  Lys Tyr Phe 
    1445                 1450                 1455             


Glu Asp  Met Lys Ser Asn Cys  Asp Pro Pro Lys Gly  Ala Asp Asp 
    1460                 1465                 1470             


Cys Gly  Asp Asn Ser Asn Ile  Glu Cys Lys Lys Ala  Cys Ala Asn 
    1475                 1480                 1485             


Tyr Thr  Asn Trp Leu Asn Pro  Lys Arg Ile Glu Trp  Asn Gly Met 
    1490                 1495                 1500             


Ser Asn  Tyr Tyr Asn Lys Ile  Tyr Arg Lys Ser Asn  Lys Glu Ser 
    1505                 1510                 1515             


Glu Asp  Gly Lys Asp Tyr Ser  Met Ile Met Glu Pro  Thr Val Ile 
    1520                 1525                 1530             


Asp Tyr  Leu Asn Lys Arg Cys  His Gly Glu Ile Asn  Gly Asn Tyr 
    1535                 1540                 1545             


Ile Cys  Cys Ser Cys Lys Asn  Ile Gly Glu Asn Ser  Thr Ser Pro 
    1550                 1555                 1560             


Ala Gln  Lys Thr Lys Gly Ser  Lys Lys Lys Gly Glu  Gln Cys Glu 
    1565                 1570                 1575             


Asp Asn  Lys Gly Pro Leu Asp  Leu Met Asn Glu Val  Leu Asn Lys 
    1580                 1585                 1590             


Met Asp  Glu Lys Tyr Ser Ala  His 
    1595                 1600     


<210>  42
<211>  1632
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  42

Met Asp Ser Lys Thr Thr Ile Ala Glu Lys Ile Glu Ala Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asn Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn 
    50                  55                  60                  


Asp Pro Cys Asp Ser Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Lys Pro Glu Asn Val 
                85                  90                  95      


Phe Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Asn 
            100                 105                 110         


Leu Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Ile Leu Tyr His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Gln Asn Leu Arg Arg Met Phe Ala Lys Ile Arg Glu 
            180                 185                 190         


Asn Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Thr 
        195                 200                 205             


Lys Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly 
225                 230                 235                 240 


Trp Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Gln Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr 
        275                 280                 285             


Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Glu Tyr Asp Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser 
305                 310                 315                 320 


Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp 
                325                 330                 335     


Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Asn Asp Leu Tyr Gln 
            340                 345                 350         


Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asn 
        355                 360                 365             


Tyr Val Lys Glu Phe Phe Lys Asn Phe Lys Gly Asp Asn Tyr Lys Ser 
    370                 375                 380                 


Leu Glu Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Val Thr 
385                 390                 395                 400 


Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Thr Ser Ser Glu 
                405                 410                 415     


Lys Ile Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Glu 
            420                 425                 430         


Ile Ala Ser Val Gly Gln Ala Ser Ile Ser Asp Pro Ser Ser Asn Lys 
        435                 440                 445             


Thr Cys Asn Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys 
    450                 455                 460                 


Lys Asp Val Lys Leu Gly Val Arg Glu Lys Asp Lys Asp Leu Lys Ile 
465                 470                 475                 480 


Cys Val Ile Glu Asp Asp Ser Leu Arg Gly Val Asp Asn Cys Cys Cys 
                485                 490                 495     


Gln Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Asp Glu Cys 
        515                 520                 525             


Gln Lys Lys Leu Glu Asn Val Phe Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Cys Asp Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Asn Lys Trp 
545                 550                 555                 560 


Ile Trp Arg Lys Phe Pro Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr 
                565                 570                 575     


Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Leu Leu Tyr Leu Val 
            580                 585                 590         


Cys Leu His Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg 
        595                 600                 605             


Thr Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu 
    610                 615                 620                 


Gly Lys Asn Leu Lys Thr Thr Tyr Pro Gln Lys Lys Asn Asp Asp Asn 
625                 630                 635                 640 


Gly Lys Lys Leu Cys Lys Asp Leu Lys Tyr Ser Phe Ala Asp Tyr Gly 
                645                 650                 655     


Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Asp Phe Thr Lys Asp 
            660                 665                 670         


Leu Glu Leu Asn Leu Gln Gln Ile Phe Gly Lys Leu Phe Arg Lys Tyr 
        675                 680                 685             


Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp 
705                 710                 715                 720 


Thr Ala Met Lys His Gly Ala Gly Met Asn Ser Thr Met Cys Asn Ala 
                725                 730                 735     


Asp Gly Ser Val Thr Gly Ser Ser Asp Ser Gly Ser Thr Thr Cys Ser 
            740                 745                 750         


Gly Asp Asn Gly Ser Ile Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu 
        755                 760                 765             


Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe Cys 
    770                 775                 780                 


Glu Gln Arg Gln Ala Lys Val Asn Ala Val Ile Thr Asn Cys Lys Ser 
785                 790                 795                 800 


Cys Lys Glu Ser Gly Gly Thr Cys Asn Ser Asp Cys Lys Thr Glu Cys 
                805                 810                 815     


Lys Asn Lys Cys Lys Val Ala Cys Asp Ala Tyr Lys Thr Phe Ile Glu 
            820                 825                 830         


Asp Cys Lys Gly Gly Gly Thr Gly Thr Ala Gly Ser Ser Trp Val Lys 
        835                 840                 845             


Arg Trp Tyr Gln Ile Tyr Met Arg Tyr Ser Lys Tyr Ile Glu Asp Ala 
    850                 855                 860                 


Lys Arg Asn Arg Lys Ala Gly Thr Lys Ser Cys Gly Thr Ser Ser Gly 
865                 870                 875                 880 


Ala Asn Ser Gly Val Thr Thr Ala Glu Asn Lys Cys Val Gln Ser Asp 
                885                 890                 895     


Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro 
            900                 905                 910         


Ser Ser Tyr Leu Ser Asn Val Leu Asp Glu Asn Asn Cys Gly Glu Asp 
        915                 920                 925             


Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Tyr Thr Thr Tyr 
    930                 935                 940                 


Thr Thr Thr Lys Asn Cys Asp Lys Asp Lys Lys Lys Ser Lys Ser Gln 
945                 950                 955                 960 


Ser Cys Asp Thr Leu Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
                965                 970                 975     


Thr Pro His Gly Tyr Lys Tyr Ala Cys Glu Cys Lys Ile Pro Thr Thr 
            980                 985                 990         


Glu Glu Thr Cys Asp Asp Arg Lys  Glu Tyr Met Asn Gln  Trp Ile Ile 
        995                 1000                 1005             


Asp Thr  Ser Lys Lys Gln Lys  Gly Ser Gly Ser Thr  Asn Asn Asp 
    1010                 1015                 1020             


Tyr Glu  Leu Tyr Thr Tyr Asn  Gly Val Lys Glu Thr  Lys Pro Leu 
    1025                 1030                 1035             


Gly Thr  Leu Asn Ser Ser Lys  Leu Asp Asp Lys Asp  Val Met Phe 
    1040                 1045                 1050             


Phe Asn  Leu Phe Glu Gln Trp  Asn Lys Glu Ile Gln  Tyr Gln Ile 
    1055                 1060                 1065             


Glu Gln  Tyr Met Thr Asn Thr  Lys Ile Ser Cys Asn  Asn Glu Met 
    1070                 1075                 1080             


Lys Val  Leu Ser Ser Ser Ser  Glu Glu Ser Gln Asn  Arg Asn Gly 
    1085                 1090                 1095             


Ser Asp  His His Asp Gly Arg  Asn Asn Asn Ile Asn  Gln Gly Thr 
    1100                 1105                 1110             


Asn Cys  Lys Glu Lys Cys Lys  Cys Tyr Glu Leu Trp  Ile Lys Lys 
    1115                 1120                 1125             


Ile Lys  Glu Gln Trp Asp Lys  Gln Lys Asn Asn Tyr  Asn Lys Phe 
    1130                 1135                 1140             


Gln Arg  Lys Gln Ile Tyr Asp  Ala Asn Lys Gly Pro  Gln Asn Lys 
    1145                 1150                 1155             


Lys Val  Val Ser Leu Ser His  Phe Leu Phe Phe Ser  Cys Trp Glu 
    1160                 1165                 1170             


Glu Tyr  Ile Gln Lys Tyr Phe  Asn Gly Asp Trp Ser  Lys Ile Lys 
    1175                 1180                 1185             


Asn Ile  Gly Ser Asp Thr Phe  Glu Tyr Leu Ile Lys  Lys Cys Gly 
    1190                 1195                 1200             


Asn Asn  Ser Gly Asp Gly Glu  Thr Ile Phe Ser Glu  Lys Leu Lys 
    1205                 1210                 1215             


Asn Ala  Glu Lys Lys Cys Lys  Glu Asn Lys Ser Thr  Asn Asn Lys 
    1220                 1225                 1230             


Met Lys  Ser Ser Gly Lys Ser  Ser Asp Gly Ser Gly  Ser Gly Ala 
    1235                 1240                 1245             


Glu Lys  Lys Asn Asn Lys Ser  Leu Cys His Glu Lys  Gly Asn Asp 
    1250                 1255                 1260             


Arg Thr  Trp Ser Lys Lys Tyr  Ile Lys Lys Leu Glu  Asn Gly Arg 
    1265                 1270                 1275             


Thr Leu  Glu Gly Val Tyr Val  Pro Pro Arg Arg Gln  Gln Leu Cys 
    1280                 1285                 1290             


Leu Tyr  Glu Leu Phe Pro Ile  Ile Ile Lys Lys Glu  Lys Asp Met 
    1295                 1300                 1305             


Glu Lys  Ala Lys Lys Glu Leu  Leu Glu Thr Leu Lys  Ile Val Ala 
    1310                 1315                 1320             


Glu Arg  Glu Ala Tyr Tyr Leu  Trp Lys Gln Tyr Asn  Pro Thr Gly 
    1325                 1330                 1335             


Lys Gly  Ile Asp Asp Ala Asn  Lys Lys Ala Cys Cys  Ala Ile Arg 
    1340                 1345                 1350             


Gly Ser  Phe Tyr Asp Leu Glu  Asp Ile Ile Lys Gly  Asn Asp Leu 
    1355                 1360                 1365             


Val His  Asp Glu Tyr Thr Lys  Tyr Ile Asp Ser Lys  Leu Asn Glu 
    1370                 1375                 1380             


Ile Phe  Gly Ser Ser Asn Lys  Asn Asp Ile Asp Thr  Lys Arg Ala 
    1385                 1390                 1395             


Arg Thr  Asp Trp Trp Glu Asn  Glu Thr Ile Asp Val  Pro Asn Ile 
    1400                 1405                 1410             


Thr Gly  Ala Asn Lys Ser Asp  Ser Lys Thr Ile Arg  Gln Leu Val 
    1415                 1420                 1425             


Trp Asp  Ala Met Gln Ser Gly  Val Arg Lys Ala Ile  Tyr Glu Glu 
    1430                 1435                 1440             


Lys Glu  Lys Lys Lys Gln Asn  Glu Asn Phe Pro Pro  Cys Met Arg 
    1445                 1450                 1455             


Val Glu  His Ile Gly Ile Ala  Lys Pro Gln Phe Ile  Arg Trp Leu 
    1460                 1465                 1470             


Glu Glu  Trp Thr Asn Glu Phe  Cys Glu Glu Tyr Thr  Lys Tyr Phe 
    1475                 1480                 1485             


Glu Asp  Met Lys Ser Lys Cys  Asp Pro Pro Lys Arg  Ala Asp Asp 
    1490                 1495                 1500             


Cys Gly  Asp Asn Thr Asn Ile  Glu Cys Lys Lys Ala  Cys Ala Asn 
    1505                 1510                 1515             


Tyr Thr  Asn Trp Leu Asn Pro  Lys Arg Ile Glu Trp  Asn Gly Met 
    1520                 1525                 1530             


Ser Asn  Tyr Tyr Asn Lys Ile  Tyr Arg Lys Ser Asn  Lys Glu Ser 
    1535                 1540                 1545             


Glu Asp  Gly Lys Asp Tyr Ser  Met Ile Met Glu Pro  Thr Val Ile 
    1550                 1555                 1560             


Asp Tyr  Leu Asn Lys Arg Cys  His Gly Glu Ile Asn  Gly Asn Tyr 
    1565                 1570                 1575             


Ile Cys  Cys Ser Cys Lys Asn  Ile Gly Glu Asn Tyr  Asn Pro Ser 
    1580                 1585                 1590             


Pro Ala  Gln Lys Thr Lys Gly  Ser Lys Lys Lys Asp  Glu Gln Cys 
    1595                 1600                 1605             


Glu Asp  Asn Lys Gly Pro Leu  Asp Leu Met Asn Glu  Val Leu Asn 
    1610                 1615                 1620             


Lys Met  Asp Glu Lys Tyr Ser  Ala His 
    1625                 1630         


<210>  43
<211>  1355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  43

Met Asp Lys Ser Ser Ile Gly Asp Lys Ile Glu Glu Tyr Leu Lys Glu 
1               5                   10                  15      


Lys Ser Asp Asp Ser Lys Ile Asp Glu Leu Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Lys Asn 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr Glu 
    50                  55                  60                  


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Gln Gln Asn Leu Tyr Lys Ala Ser Glu Asn Asn Lys Asn Val Phe 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Asn Leu 
            100                 105                 110         


Asn Val Glu Arg Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Ile Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Ile Ala Asp Ile Ile Arg Gly Arg Asp Gly Asn Lys Cys Glu Thr Lys 
                165                 170                 175     


Ser Thr Asn Asn Val Glu Glu Leu Ile Lys Lys Phe Phe Glu Lys Asn 
            180                 185                 190         


Tyr Arg Glu Asn Lys Glu Tyr Lys Arg Lys Tyr Pro Asn Asp Asp Pro 
        195                 200                 205             


Lys Tyr Thr Lys Leu Arg Glu Asp Trp Trp Thr Lys Asn Arg Gln Lys 
    210                 215                 220                 


Val Trp Glu Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile 
225                 230                 235                 240 


Lys Arg Gly Trp Thr Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys Leu 
                245                 250                 255     


Glu Leu Cys Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys 
            260                 265                 270         


Leu Asp Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu 
        275                 280                 285             


Asp Leu Tyr Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His 
    290                 295                 300                 


Arg Glu Glu Cys Thr Ser Glu Asp His Lys Ser Lys Glu Gly Ala Ser 
305                 310                 315                 320 


Tyr Cys Asn Met Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val 
                325                 330                 335     


Lys Lys Trp Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Lys Asp 
            340                 345                 350         


Leu Tyr Gln Gln Glu Asn Glu Thr Ser Ser Ser Ser Lys Lys Lys Ser 
        355                 360                 365             


Arg Tyr Asp Asp Tyr Val Lys Glu Phe Phe Lys Lys Leu Asn Glu Ala 
    370                 375                 380                 


Asn Tyr Ser Ser Leu Glu Asn Tyr Ile Lys Asp Asp Pro Tyr Ser Lys 
385                 390                 395                 400 


Glu Tyr Val Thr Lys Leu Ser Phe Ile Pro Asn Ser Ser Asp Ala Asn 
                405                 410                 415     


Thr Ser Ser Glu Lys Ile Gln Lys Asn Asn Asp Glu Val Cys Asn Pro 
            420                 425                 430         


Asn Glu Ser Gly Ile Ser Ser Val Glu Gln Ala Gln Thr Ser Gly Pro 
        435                 440                 445             


Ser Ser Asn Lys Thr Cys Ile Thr His Ser Ser Ile Lys Ala Asn Lys 
    450                 455                 460                 


Lys Lys Glu Cys Lys Asp Val Lys Leu Gly Val Arg Glu Asn Asp Lys 
465                 470                 475                 480 


Asp Leu Lys Ile Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp 
                485                 490                 495     


Asn Cys Cys Cys Gln Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser 
            500                 505                 510         


Asp Asn Lys Arg Gly Ser Ser Ser Asn Asp Ser Cys Asp Asn Lys Asn 
        515                 520                 525             


Gln Asp Glu Cys Gln Lys Lys Leu Asp Glu Ala Leu Glu Ser Leu His 
    530                 535                 540                 


Asn Gly Tyr Lys Asn Gln Lys Cys Lys Ser Gly Thr Ser Thr Val Asn 
545                 550                 555                 560 


Lys Lys Trp Ile Trp Lys Lys Ser Ser Gly Asn Lys Glu Gly Leu Gln 
                565                 570                 575     


Lys Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu 
            580                 585                 590         


Tyr Leu Gly Asn Leu Pro Lys Leu Glu Asn Val Ser Lys Gly Val Thr 
        595                 600                 605             


Asp Ile Ile Tyr Asp Thr Lys Glu Lys Phe Leu Ala Gly Cys Leu Ile 
    610                 615                 620                 


Val Ser Phe His Glu Gly Lys Asn Leu Lys Thr Ser His Glu Lys Lys 
625                 630                 635                 640 


Asn Asp Asp Asn Gly Lys Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe 
                645                 650                 655     


Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu 
            660                 665                 670         


Tyr Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ala Phe Gly Lys Leu 
        675                 680                 685             


Phe Arg Lys Tyr Ile Lys Lys Asn Ile Ser Ala Glu Gln Asp Thr Ser 
    690                 695                 700                 


Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys 
705                 710                 715                 720 


Lys Tyr Ile Trp Ile Ala Met Lys His Gly Ala Gly Met Asn Gly Thr 
                725                 730                 735     


Thr Cys Cys Gly Asp Gly Ser Ser Gly Glu Asn Gln Thr Asn Ser Cys 
            740                 745                 750         


Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu 
        755                 760                 765             


Gln Glu Trp Val Glu His Phe Cys Glu Gln Arg Gln Ala Lys Val Lys 
    770                 775                 780                 


Asp Val Ile Thr Asn Cys Lys Ser Cys Lys Asn Thr Ser Gly Glu Arg 
785                 790                 795                 800 


Lys Ile Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Lys Cys Lys Asn 
                805                 810                 815     


Lys Cys Glu Ala Tyr Lys Thr Phe Ile Glu His Cys Lys Gly Gly Asp 
            820                 825                 830         


Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln Ile Tyr Lys 
        835                 840                 845             


Arg Tyr Ser Lys His Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly 
    850                 855                 860                 


Thr Lys Ser Cys Gly Thr Ser Thr Ala Glu Asn Lys Cys Val Gln Ser 
865                 870                 875                 880 


Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr 
                885                 890                 895     


Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp Glu Asn Asn Cys Gly Glu 
            900                 905                 910         


Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Thr Lys Asn Cys Asp Ile 
        915                 920                 925             


Gln Lys Asp Lys Ser Lys Ser Gln Ser Ser Asp Thr Leu Val Val Val 
    930                 935                 940                 


Asn Val Pro Ser Pro Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala 
945                 950                 955                 960 


Cys Gln Cys Lys Ile Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                965                 970                 975     


Ala Glu Lys Lys Asn Asn Lys Ser Leu Cys His Glu Lys Gly Asn Asp 
            980                 985                 990         


Arg Thr Trp Ser Lys Lys Tyr Ile  Lys Lys Leu Glu Asn  Gly Arg Thr 
        995                 1000                 1005             


Leu Glu  Gly Val Tyr Val Pro  Pro Arg Arg Gln Gln  Leu Cys Leu 
    1010                 1015                 1020             


Tyr Glu  Leu Phe Pro Ile Ile  Ile Lys Asn Lys Asn  Asp Ile Thr 
    1025                 1030                 1035             


Asn Ala  Lys Glu Glu Leu Leu  Glu Thr Leu Gln Ile  Val Ala Glu 
    1040                 1045                 1050             


Arg Glu  Ala Tyr Tyr Leu Trp  Lys Gln Tyr Asn Pro  Thr Gly Lys 
    1055                 1060                 1065             


Gly Ile  Asp Asp Ala Asn Lys  Lys Ala Cys Cys Ala  Ile Arg Gly 
    1070                 1075                 1080             


Ser Phe  Tyr Asp Leu Glu Asp  Ile Ile Lys Gly Asn  Asp Leu Val 
    1085                 1090                 1095             


His Asp  Glu Tyr Thr Lys Tyr  Ile Asp Ser Lys Leu  Asn Glu Ile 
    1100                 1105                 1110             


Phe Gly  Ser Ser Asn Lys Asn  Asp Ile Glu Thr Lys  Arg Ala Arg 
    1115                 1120                 1125             


Thr Asp  Trp Trp Glu Asn Glu  Thr Ile Thr Asn Gly  Thr Asp Arg 
    1130                 1135                 1140             


Lys Thr  Ile Arg Gln Leu Val  Trp Asp Ala Met Gln  Ser Gly Val 
    1145                 1150                 1155             


Arg Lys  Ala Ile Asp Glu Glu  Lys Glu Lys Lys Lys  Pro Asn Glu 
    1160                 1165                 1170             


Asn Phe  Pro Pro Cys Met Gly  Val Glu His Ile Gly  Ile Ala Lys 
    1175                 1180                 1185             


Pro Gln  Phe Ile Arg Trp Leu  Glu Glu Trp Thr Asn  Glu Phe Cys 
    1190                 1195                 1200             


Glu Glu  Tyr Thr Lys Tyr Phe  Glu Asp Met Lys Ser  Asn Cys Asn 
    1205                 1210                 1215             


Arg Arg  Lys Gly Ala Asp Asp  Cys Gly Asp Asn Thr  Asn Ile Glu 
    1220                 1225                 1230             


Cys Lys  Lys Ala Cys Ala Asn  Tyr Thr Asn Trp Leu  Asn Pro Lys 
    1235                 1240                 1245             


Arg Ile  Glu Trp Asn Gly Met  Ser Asn Tyr Tyr Asn  Lys Ile Tyr 
    1250                 1255                 1260             


Arg Lys  Ser Asn Lys Glu Ser  Glu Asp Gly Lys Asp  Tyr Ser Met 
    1265                 1270                 1275             


Ile Met  Glu Pro Thr Val Ile  Asp Tyr Leu Asn Lys  Arg Cys Asn 
    1280                 1285                 1290             


Gly Glu  Ile Asn Gly Asn Tyr  Ile Cys Cys Ser Cys  Lys Asn Ile 
    1295                 1300                 1305             


Gly Ala  Tyr Asn Thr Thr Ser  Gly Thr Val Asn Lys  Lys Leu Gln 
    1310                 1315                 1320             


Lys Lys  Glu Thr Glu Cys Glu  Asp Asn Lys Gly Pro  Leu Asp Leu 
    1325                 1330                 1335             


Met Asn  Glu Val Leu Asn Lys  Met Asp Glu Lys Tyr  Ser Lys Leu 
    1340                 1345                 1350             


Asn Leu  
    1355 


<210>  44
<211>  1363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  44

Met Asp Ser Thr Ser Thr Ile Gly Asp Lys Ile Glu Ala Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asn Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Lys Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn 
    50                  55                  60                  


Asp Pro Cys Glu Lys Lys Glu Leu Ser Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Asn Asn Lys Asn Ile 
                85                  90                  95      


Phe Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Lys 
            100                 105                 110         


Leu Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Ile Leu Tyr His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Ile Ala Asp Ile Ile Arg Gly Thr Asp Gln Leu Lys Gly Ser Asn 
                165                 170                 175     


Ile Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Lys 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Pro Asn Asp Asp Glu Asn Tyr Lys 
        195                 200                 205             


Lys Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Arg 
225                 230                 235                 240 


Trp Thr Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys Leu Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Leu Tyr 
        275                 280                 285             


Arg Glu Glu Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Lys Asn Val Glu Ser Asn Glu Gly Ala Ser Tyr Cys Asn 
305                 310                 315                 320 


Met Cys Lys Glu Lys His Thr Lys Tyr Cys Glu Cys Val Lys Lys Trp 
                325                 330                 335     


Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Glu 
            340                 345                 350         


Gln Glu Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
        355                 360                 365             


Val Lys Asp Phe Phe Glu Lys Leu Lys Gly Asn Gly Tyr Ser Ser Ala 
    370                 375                 380                 


Asn Ser Tyr Val Lys Asp Asp Pro Tyr Ser Ala Glu Tyr Val Thr Lys 
385                 390                 395                 400 


Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Thr Ser Ser Glu Thr 
                405                 410                 415     


Pro Ser Lys Tyr Tyr Asp Glu Val Cys Asn Cys Asn Glu Ser Glu Ile 
            420                 425                 430         


Ser Ser Val Gly Gln Ala Gln Thr Ser Gly Pro Ser Ser Asn Lys Thr 
        435                 440                 445             


Cys Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Val Cys Lys 
    450                 455                 460                 


Asp Val Lys Leu Gly Ile Asn Asn Asn Asp Lys Val Leu Arg Val Cys 
465                 470                 475                 480 


Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys Gln 
                485                 490                 495     


Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Lys Asn Gln Ser 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Asp Glu Cys 
        515                 520                 525             


Gln Lys Lys Leu Glu Lys Val Phe Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Cys Asp Lys Cys Lys Ser Gly Thr Ser Arg Ser Lys Lys Lys Trp Ile 
545                 550                 555                 560 


Trp Arg Lys Ser Ser Gly Asn Glu Glu Gly Leu Gln Lys Glu Tyr Ala 
                565                 570                 575     


Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Tyr Leu Gly Asn 
            580                 585                 590         


Leu Pro Lys Leu Glu Asn Val Cys Lys Gly Val Thr Asp Ile Ile Tyr 
        595                 600                 605             


Asp Thr Lys Glu Lys Phe Leu Ser Gly Cys Leu Ile Ala Ala Phe His 
    610                 615                 620                 


Glu Gly Lys Asn Leu Lys Thr Ser His Glu Lys Lys Asn Asp Asp Asn 
625                 630                 635                 640 


Gly Lys Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly 
                645                 650                 655     


Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Asp Phe Thr Lys Asp 
            660                 665                 670         


Leu Glu Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr 
        675                 680                 685             


Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp 
705                 710                 715                 720 


Thr Ala Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Ser Gly 
                725                 730                 735     


Asp Gly Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Met Pro Thr 
            740                 745                 750         


Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu 
        755                 760                 765             


His Phe Cys Lys Gln Arg Gln Glu Lys Val Lys Asp Val Ile Thr Asn 
    770                 775                 780                 


Cys Asn Ser Cys Lys Glu Cys Gly Asp Thr Cys Asn Gly Glu Cys Lys 
785                 790                 795                 800 


Thr Glu Cys Lys Thr Lys Cys Lys Gly Glu Cys Glu Lys Tyr Lys Asn 
                805                 810                 815     


Phe Ile Glu Glu Cys Asn Gly Thr Ala Asp Gly Gly Thr Ser Gly Ser 
            820                 825                 830         


Ser Trp Ser Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys Tyr 
        835                 840                 845             


Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly 
    850                 855                 860                 


Thr Ser Ser Thr Thr Asn Ala Ala Ala Ser Thr Thr Glu Asn Lys Cys 
865                 870                 875                 880 


Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly 
                885                 890                 895     


Leu Thr Thr Pro Ser Ser Tyr Leu Ser Asn Val Leu Asp Asp Asn Ile 
            900                 905                 910         


Cys Gly Glu Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr 
        915                 920                 925             


Lys Asn Cys Asp Ile Gln Lys Lys Thr Pro Lys Pro Gln Ser Cys Asp 
    930                 935                 940                 


Thr Leu Val Val Val Asn Val Pro Ser Pro Leu Gly Asn Thr Pro His 
945                 950                 955                 960 


Gly Tyr Lys Tyr Val Cys Glu Cys Lys Ile Pro Gly Gly Gly Gly Ser 
                965                 970                 975     


Gly Gly Gly Gly Ser Ala Glu Lys Lys Asn Asn Lys Ser Leu Cys His 
            980                 985                 990         


Glu Lys Gly Asn Asp Arg Thr Trp  Ser Lys Lys Tyr Ile  Lys Lys Leu 
        995                 1000                 1005             


Glu Asn  Gly Arg Ser Leu Glu  Gly Val Tyr Val Pro  Pro Arg Arg 
    1010                 1015                 1020             


Gln Gln  Leu Cys Leu Tyr Glu  Leu Phe Pro Ile Ile  Ile Lys Asn 
    1025                 1030                 1035             


Glu Glu  Gly Met Glu Lys Ala  Lys Glu Glu Leu Leu  Glu Thr Leu 
    1040                 1045                 1050             


Gln Ile  Val Ala Glu Arg Glu  Ala Tyr Tyr Leu Trp  Lys Gln Tyr 
    1055                 1060                 1065             


Asn Pro  Thr Gly Lys Gly Ile  Asp Asp Ala Asn Lys  Lys Ala Cys 
    1070                 1075                 1080             


Cys Ala  Ile Arg Gly Ser Phe  Tyr Asp Leu Glu Asp  Ile Ile Lys 
    1085                 1090                 1095             


Gly Asn  Asp Leu Val His Asp  Glu Tyr Thr Lys Tyr  Ile Asp Ser 
    1100                 1105                 1110             


Lys Leu  Asn Glu Ile Phe Gly  Ser Ser Asn Lys Asn  Asp Ile Asp 
    1115                 1120                 1125             


Thr Lys  Arg Ala Arg Thr Asp  Trp Trp Glu Asn Glu  Thr Ile Asp 
    1130                 1135                 1140             


Val Ala  Asn Gly Thr Asp His  Lys Thr Ile Arg Gln  Leu Val Trp 
    1145                 1150                 1155             


Asp Ala  Met Gln Ser Gly Val  Arg Lys Ala Ile Asp  Glu Glu Asn 
    1160                 1165                 1170             


Glu Lys  Lys Lys Gln Asn Lys  Asn Phe Pro Pro Cys  Met Gly Val 
    1175                 1180                 1185             


Glu His  Ile Gly Ile Ala Lys  Pro Gln Phe Ile Arg  Trp Leu Glu 
    1190                 1195                 1200             


Glu Trp  Thr Asn Glu Phe Cys  Glu Glu Tyr Thr Lys  Tyr Phe Gly 
    1205                 1210                 1215             


Ala Ile  Asn Ser Asn Cys Asn  Arg Arg Lys Gly Ala  Asp Asp Cys 
    1220                 1225                 1230             


Gly Asp  Asn Ser Asn Ile Glu  Cys Lys Arg Ala Cys  Ala Asn Tyr 
    1235                 1240                 1245             


Thr Asn  Trp Leu Asn Pro Lys  Arg Ile Glu Trp Asn  Gly Met Ser 
    1250                 1255                 1260             


Asn Tyr  Tyr Asn Lys Ile Tyr  Arg Lys Ser Asn Lys  Glu Ser Glu 
    1265                 1270                 1275             


Asp Gly  Lys Asp Tyr Ser Met  Ile Met Ala Pro Thr  Val Ile Asp 
    1280                 1285                 1290             


Tyr Leu  Asn Lys Arg Cys Asn  Gly Glu Ile Asn Gly  Asn Tyr Ile 
    1295                 1300                 1305             


Cys Cys  Ser Cys Lys Asn Ile  Gly Glu Asn Tyr Asn  Pro Ser Pro 
    1310                 1315                 1320             


Ala Gln  Lys Thr Lys Gly Ser  Lys Lys Lys Asp Glu  Gln Cys Glu 
    1325                 1330                 1335             


Asp Asn  Lys Gly Pro Leu Asp  Leu Met Asn Glu Val  Leu Asn Lys 
    1340                 1345                 1350             


Met Asp  Glu Lys Tyr Ser Ala  His Lys Met 
    1355                 1360             


<210>  45
<211>  1360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  45

Met Asp Ser Thr Ser Thr Ile Gly Asp Lys Ile Glu Glu Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asn Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Lys Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Glu Pro Cys Asp Ser Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Asp Glu Asn Leu Phe Lys Ala Ser Gly Asn His Lys Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Gln His Met Cys Ile Lys Asn Leu Glu Asn 
            100                 105                 110         


Leu Lys Phe Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Ile Leu Tyr His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Ile Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Lys Phe Glu Pro Tyr Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Lys 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Gln Asn Asp Asp Glu Asn Tyr Lys 
        195                 200                 205             


Lys Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Arg 
225                 230                 235                 240 


Trp Arg Thr Ser Gly Lys Ser Asn Gly Glu Asn Lys Leu Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Tyr Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Leu Tyr 
        275                 280                 285             


Arg Glu Glu Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Lys Asn Val Asp Ser Lys Glu Gly Thr Ser Tyr Cys Asn 
305                 310                 315                 320 


Met Cys Lys Glu Lys His Thr Lys Tyr Cys Glu Phe Val Asn Lys Trp 
                325                 330                 335     


Lys Ser Glu Trp Lys Asn Gln Glu Asn Lys Tyr Lys Asp Leu Tyr Gln 
            340                 345                 350         


Gln Glu Asn Lys Thr Ser Ser Ser Ser Lys Asn Thr Ser Arg Tyr Asp 
        355                 360                 365             


Asn Tyr Val Lys Glu Phe Phe Glu Lys Leu Glu Ala Asn Tyr Lys Ser 
    370                 375                 380                 


Leu Glu Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Val Thr 
385                 390                 395                 400 


Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Thr Ser Ser Gly 
                405                 410                 415     


Glu Thr Ala Asn His Asn Asp Glu Ala Cys Asn Arg Asn Glu Ser Glu 
            420                 425                 430         


Ile Ser Ser Val Glu Gln Ala Pro Ile Ser Gly Pro Ser Ser Asn Lys 
        435                 440                 445             


Thr Cys Asn Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Glu Cys 
    450                 455                 460                 


Lys Asp Val Lys Leu Gly Ile Asn Asn Asn Asp Lys Asp Leu Lys Ile 
465                 470                 475                 480 


Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys 
                485                 490                 495     


Gln Asp Phe Leu Arg Met Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asp Asn Lys Asn Gln Asp Glu Cys 
        515                 520                 525             


Gln Thr Lys Leu Asp Glu Ala Leu Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Cys Glu Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Asn Gln Trp 
545                 550                 555                 560 


Ile Trp Lys Lys Ser Arg Gly Thr Glu Gly Gly Leu Gln Glu Glu Tyr 
                565                 570                 575     


Ala Asn Thr Ile Ala Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val 
            580                 585                 590         


Cys Leu His Glu Lys Glu Glu Lys Thr Gln His Lys Thr Ile Ser Thr 
        595                 600                 605             


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
    610                 615                 620                 


Lys Asn Leu Lys Lys Arg Tyr His Gln Asn Lys Asn Ala Asp Asn Glu 
625                 630                 635                 640 


Lys Lys Lys Gly Glu Asn Lys Lys Lys Leu Cys Lys Ala Leu Lys Tyr 
                645                 650                 655     


Ser Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp 
            660                 665                 670         


Asn Glu Tyr Thr Lys Asp Leu Glu Leu Asn Leu Gln Gln Ile Phe Gly 
        675                 680                 685             


Lys Leu Phe Arg Lys Tyr Ile Lys Lys Asn Ile Ser Thr Glu Gln Asp 
    690                 695                 700                 


Thr Leu Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr 
705                 710                 715                 720 


Asn Lys Lys Tyr Ile Trp Leu Ala Met Lys His Gly Ala Glu Met Asn 
                725                 730                 735     


Gly Thr Thr Cys Cys Gly Asp Gly Ser Ser Gly Glu Asn Gln Thr Asn 
            740                 745                 750         


Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg 
        755                 760                 765             


Phe Leu Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg Gln Glu Asn 
    770                 775                 780                 


Val Asn Ala Val Ile Glu Asn Cys Lys Ser Cys Lys Glu Cys Gly Gly 
785                 790                 795                 800 


Thr Cys Gly Ser Asp Cys Lys Thr Glu Cys Glu Lys Lys Cys Lys Ala 
                805                 810                 815     


Tyr Lys Glu Phe Ile Glu Lys Cys Glu Gly Gln Ala Ala Glu Gly Thr 
            820                 825                 830         


Ser Gly Tyr Ser Trp Ser Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr 
        835                 840                 845             


Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys 
    850                 855                 860                 


Asn Cys Gly Thr Ser Ser Gly Ala Thr Ser Gly Val Thr Thr Thr Glu 
865                 870                 875                 880 


Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile 
                885                 890                 895     


Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp 
            900                 905                 910         


Asp Asn Ile Cys Gly Ala Asp Asn Ala Pro Trp Thr Thr Tyr Thr Thr 
        915                 920                 925             


Tyr Thr Thr Lys Asn Cys Asp Lys Glu Lys Asp Lys Ser Lys Ser Gln 
    930                 935                 940                 


Ser Cys Asp Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
945                 950                 955                 960 


Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro Gly Gly 
                965                 970                 975     


Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Lys Lys Asn Asn Lys Ser 
            980                 985                 990         


Leu Cys His Glu Lys Gly Asn Asp  Arg Thr Trp Ser Lys  Lys Tyr Ile 
        995                 1000                 1005             


Lys Lys  Leu Glu Asn Gly Arg  Thr Leu Glu Gly Val  Tyr Val Pro 
    1010                 1015                 1020             


Pro Arg  Arg Gln Gln Leu Cys  Leu Tyr Glu Leu Phe  Pro Ile Ile 
    1025                 1030                 1035             


Ile Lys  Lys Glu Lys Asp Met  Glu Lys Ala Lys Glu  Leu Leu Glu 
    1040                 1045                 1050             


Thr Leu  Gln Ile Val Ala Glu  Arg Glu Ala Tyr Tyr  Leu Trp Lys 
    1055                 1060                 1065             


Gln Tyr  Asn Pro Thr Gly Lys  Gly Ile Asp Asp Ala  Asn Lys Lys 
    1070                 1075                 1080             


Ala His  Lys Lys Ala Cys Cys  Ala Ile Arg Gly Ser  Phe Tyr Asp 
    1085                 1090                 1095             


Leu Glu  Asp Ile Ile Lys Gly  Asn Asp Leu Val His  Asp Glu Tyr 
    1100                 1105                 1110             


Thr Lys  Tyr Ile Asp Ser Lys  Leu Asn Glu Ile Phe  Gly Ser Ser 
    1115                 1120                 1125             


Asn Thr  Asn Asp Ile Glu Thr  Lys Arg Ala Arg Thr  Asp Trp Trp 
    1130                 1135                 1140             


Glu Asn  Glu Thr Ile Gly Val  Ala Asn Gly Thr Asp  Ser Lys Thr 
    1145                 1150                 1155             


Ile Arg  Gln Leu Val Trp Asp  Ala Met Gln Ser Gly  Val Ile Tyr 
    1160                 1165                 1170             


Ala Glu  Glu Lys Lys Glu Asn  Phe Pro Pro Cys Met  Arg Val Glu 
    1175                 1180                 1185             


His Ile  Gly Ile Ala Lys Pro  Gln Phe Ile Arg Trp  Leu Glu Glu 
    1190                 1195                 1200             


Trp Thr  Asn Glu Phe Cys Glu  Lys Tyr Thr Lys Tyr  Phe Glu Asp 
    1205                 1210                 1215             


Met Lys  Ser Lys Cys Asp Pro  Pro Lys Gly Ala Asp  Asp Cys Asp 
    1220                 1225                 1230             


Asp Asn  Ser Asn Ile Glu Cys  Lys Arg Ala Cys Ala  Asn Tyr Thr 
    1235                 1240                 1245             


Asn Trp  Leu Asn Pro Lys Arg  Ile Glu Trp Asn Gly  Met Ser Asn 
    1250                 1255                 1260             


Tyr Tyr  Asn Lys Ile Tyr Arg  Lys Ser Asn Lys Glu  Ser Glu Asp 
    1265                 1270                 1275             


Gly Lys  Asp Tyr Ser Met Ile  Met Glu Pro Thr Val  Ile Asp Tyr 
    1280                 1285                 1290             


Leu Asn  Lys Arg Cys His Gly  Glu Ile Asn Gly Asn  Tyr Ile Cys 
    1295                 1300                 1305             


Cys Ser  Cys Lys Asn Ile Gly  Glu Asn Ser Thr Ser  Gly Thr Val 
    1310                 1315                 1320             


Asn Lys  Lys Leu Gln Lys Lys  Glu Thr Glu Cys Glu  Asp Asn Lys 
    1325                 1330                 1335             


Gly Pro  Leu Asp Leu Met Asn  Glu Val Leu Asn Lys  Met Asp Lys 
    1340                 1345                 1350             


Lys Tyr  Ser Ala His Lys Met  
    1355                 1360 


<210>  46
<211>  1348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  46

Met Asp Lys Ser Ser Ile Gly Asp Lys Ile Glu Ala Tyr Leu Glu Lys 
1               5                   10                  15      


Lys Ser Asp Glu Ser Asp Ile Glu Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Arg Lys 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr Glu 
    50                  55                  60                  


Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Ile Asp Glu Trp Lys 
65                  70                  75                  80  


Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Lys Pro Glu Asn Ile Cys 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Asn Leu 
            100                 105                 110         


Lys Phe Asp Lys Ile Arg Asp Asn Asn Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn Lys 
                165                 170                 175     


Phe Glu Pro Cys Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn Asp 
            180                 185                 190         


Lys Val Leu Gln Asp Lys Tyr Pro Asn Asp Asp Pro Lys Tyr Thr Lys 
        195                 200                 205             


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
    210                 215                 220                 


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Leu Gly Trp 
225                 230                 235                 240 


Thr Ser Ser Lys Glu Ser Glu Gly Asp Asn Lys Leu Glu Leu Cys Arg 
                245                 250                 255     


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
            260                 265                 270         


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
        275                 280                 285             


Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His Arg Glu Glu Cys 
    290                 295                 300                 


Thr Arg Lys Asn Val Glu Ser Lys Glu Gly Thr Ser Tyr Cys Thr Asn 
305                 310                 315                 320 


Cys Lys Glu Lys Cys Lys Lys Tyr Cys Glu Tyr Val Asn Lys Trp Lys 
                325                 330                 335     


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Asn Asp Leu Tyr Gln Gln 
            340                 345                 350         


Glu Asn Lys Thr Ser Ser Ser Ser Lys Lys Lys Ser Arg Tyr Asp Asp 
        355                 360                 365             


Tyr Val Lys Glu Phe Phe Lys Asn Phe Lys Gly Asp Asn Tyr Lys Ser 
    370                 375                 380                 


Leu Glu Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr 
385                 390                 395                 400 


Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Thr Glu Asn Ala Ser Glu 
                405                 410                 415     


Thr Pro Ser Lys Tyr Tyr Asp Glu Ala Cys Asn Cys Asn Glu Ser Glu 
            420                 425                 430         


Ile Ala Ser Val Gly Gln Ala Gln Thr Ser Gly Pro Ser Ser Asn Lys 
        435                 440                 445             


Thr Cys Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Glu Cys 
    450                 455                 460                 


Lys Asp Val Lys Leu Gly Ile Asn Asn Asn Asp Lys Val Leu Arg Val 
465                 470                 475                 480 


Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys 
                485                 490                 495     


Gln Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asp Lys Asn Ser Glu Glu Ile Cys 
        515                 520                 525             


Gln Lys Lys Leu Glu Lys Val Phe Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Cys Asp Lys Cys Lys Ser Gly Thr Ser Arg Ser Lys Lys Lys Trp Ile 
545                 550                 555                 560 


Trp Lys Lys Ser Ser Gly Asn Glu Glu Gly Leu Gln Lys Glu Tyr Ala 
                565                 570                 575     


Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Cys 
            580                 585                 590         


Leu His Glu Lys Glu Gly Lys Thr Gln His Lys Thr Ile Ser Thr Asn 
        595                 600                 605             


Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly Lys 
    610                 615                 620                 


Asn Leu Lys Thr Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys Lys 
625                 630                 635                 640 


Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile 
                645                 650                 655     


Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu Leu 
            660                 665                 670         


Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys Lys 
        675                 680                 685             


Asn Asn Thr Ala Glu Gln His Thr Ser Tyr Ser Ser Leu Asp Glu Leu 
    690                 695                 700                 


Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Thr Ala Met 
705                 710                 715                 720 


Lys His Gly Ala Gly Met Asn Gly Thr Thr Cys Ser Cys Ser Gly Asp 
                725                 730                 735     


Ser Ser Asn Asp Met Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg 
            740                 745                 750         


Phe Leu Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg Gln Glu Lys 
        755                 760                 765             


Val Asn Ala Val Ile Glu Asn Cys Asn Ser Cys Lys Glu Ser Gly Gly 
    770                 775                 780                 


Thr Cys Asn Ser Asp Cys Lys Thr Glu Cys Lys Asn Lys Cys Glu Ala 
785                 790                 795                 800 


Tyr Lys Glu Phe Ile Glu Asp Cys Lys Gly Gly Gly Thr Gly Thr Ala 
                805                 810                 815     


Gly Ser Pro Trp Ser Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser 
            820                 825                 830         


Lys His Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn 
        835                 840                 845             


Cys Gly Thr Ser Ser Thr Thr Asn Ala Ala Ala Ser Thr Asp Glu Asn 
    850                 855                 860                 


Lys Cys Val Gln Ser Asp Val Asp Ser Phe Phe Lys His Leu Ile Asp 
865                 870                 875                 880 


Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Asn Val Leu Asp Asp 
                885                 890                 895     


Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr 
            900                 905                 910         


Thr Thr Thr Lys Asn Cys Asp Ile Gln Lys Lys Thr Pro Lys Ser Gln 
        915                 920                 925             


Ser Cys Asp Thr Leu Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
    930                 935                 940                 


Thr Pro His Glu Tyr Lys Tyr Ala Cys Glu Cys Lys Ile Pro Gly Gly 
945                 950                 955                 960 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Gly Gln Asn Asn Lys Ser 
                965                 970                 975     


Leu Cys His Glu Lys Gly Asn Asp Arg Thr Trp Ser Lys Lys Tyr Ile 
            980                 985                 990         


Lys Lys Leu Glu Asn Gly Arg Thr  Leu Glu Gly Val Tyr  Val Pro Pro 
        995                 1000                 1005             


Arg Arg  Gln Gln Leu Cys Leu  Tyr Glu Leu Phe Pro  Ile Ile Ile 
    1010                 1015                 1020             


Lys Lys  Glu Lys Asp Met Glu  Lys Ala Lys Glu Glu  Leu Leu Glu 
    1025                 1030                 1035             


Thr Leu  Gln Ile Val Ala Glu  Arg Glu Ala Tyr Tyr  Leu Trp Lys 
    1040                 1045                 1050             


Gln Tyr  His Ala His Asn Asp  Thr Thr Tyr Leu Ala  His Lys Lys 
    1055                 1060                 1065             


Ala Cys  Cys Ala Ile Arg Gly  Ser Phe Tyr Asp Leu  Glu Asp Ile 
    1070                 1075                 1080             


Ile Lys  Gly Asn Asp Leu Val  His Asp Glu Tyr Thr  Lys Tyr Ile 
    1085                 1090                 1095             


Asp Ser  Lys Leu Asn Glu Ile  Phe Gly Ser Ser Asn  Lys Asn Asp 
    1100                 1105                 1110             


Ile Glu  Thr Lys Arg Ala Arg  Thr Asp Trp Trp Glu  Asn Glu Thr 
    1115                 1120                 1125             


Ile Asp  Val Ala Asn Gly Thr  Asp Arg Lys Thr Ile  Arg Gln Leu 
    1130                 1135                 1140             


Val Trp  Asp Ala Met Gln Ser  Gly Val Arg Lys Ala  Ile Asp Glu 
    1145                 1150                 1155             


Glu Lys  Glu Lys Lys Lys Pro  Asn Lys Asn Phe Pro  Pro Cys Met 
    1160                 1165                 1170             


Gly Val  Glu His Ile Gly Ile  Ala Lys Pro Gln Phe  Ile Arg Trp 
    1175                 1180                 1185             


Leu Glu  Glu Trp Thr Asn Glu  Phe Cys Glu Glu Tyr  Thr Lys Tyr 
    1190                 1195                 1200             


Phe Gly  Ala Ile Asn Ser Asn  Cys Asn Leu Arg Lys  Gly Ala Asp 
    1205                 1210                 1215             


Asp Cys  Gly Asp Asn Ser Asn  Ile Glu Cys Lys Arg  Ala Cys Ala 
    1220                 1225                 1230             


Asn Tyr  Thr Asn Trp Leu Asn  Pro Lys Arg Ile Glu  Trp Asn Gly 
    1235                 1240                 1245             


Met Ser  Asn Tyr Tyr Asn Lys  Ile Tyr Arg Lys Ser  Asn Lys Glu 
    1250                 1255                 1260             


Ser Glu  Asp Gly Lys Asp Tyr  Ser Met Ile Met Glu  Pro Thr Val 
    1265                 1270                 1275             


Ile Asp  Tyr Leu Asn Lys Arg  Cys Asn Gly Glu Ile  Asn Gly Asn 
    1280                 1285                 1290             


Tyr Ile  Cys Cys Ser Cys Lys  Asn Ile Gly Glu Asn  Ser Thr Ser 
    1295                 1300                 1305             


Pro Val  Ala Asn Lys Lys Ala  Gln Arg Lys Glu Thr  Glu Cys Glu 
    1310                 1315                 1320             


Glu Glu  Lys Gly Pro Leu Asp  Leu Met Asn Glu Val  Leu Asn Lys 
    1325                 1330                 1335             


Met Asp  Glu Lys Tyr Ser Ala  His Lys Met 
    1340                 1345             


<210>  47
<211>  1372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  47

Met Asp Lys Ser Ser Ile Gly Asp Lys Ile Glu Glu Tyr Leu Lys Glu 
1               5                   10                  15      


Lys Ser Asn Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Arg Ser Gly Gly Asp Gly Tyr Tyr Leu Lys Asn 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Asp Glu Asn Leu Tyr Lys Ala Ser Glu Asn Asn Lys Asn Ile Phe 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Lys Leu 
            100                 105                 110         


Asn Val Glu Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Leu Ala Asp Ile Ile Arg Gly Arg Asp Gly Asn Lys Cys Glu Thr Lys 
                165                 170                 175     


Ser Thr Asn Asn Val Glu Glu Leu Ile Lys Lys Phe Phe Glu Lys Asn 
            180                 185                 190         


Tyr Arg Glu Asn Lys Glu Tyr Lys Arg Lys Tyr Arg Asn Asp Asp Pro 
        195                 200                 205             


Lys Tyr Thr Lys Leu Arg Glu Asp Trp Trp Thr Lys Asn Arg Gln Lys 
    210                 215                 220                 


Val Trp Glu Val Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile 
225                 230                 235                 240 


Lys Arg Arg Trp Arg Thr Ser Gly Lys Ser Asn Gly Glu Asn Lys Leu 
                245                 250                 255     


Glu Leu Cys Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Lys 
            260                 265                 270         


Leu Asp Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu 
        275                 280                 285             


Asp Leu Tyr Arg Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His 
    290                 295                 300                 


Arg Glu Glu Cys Thr Ser Glu Asp Asp Lys Ser Lys Glu Val Thr Ser 
305                 310                 315                 320 


Tyr Cys Asn Met Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Tyr Val 
                325                 330                 335     


Asn Lys Trp Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu 
            340                 345                 350         


Leu Tyr Glu Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Ala Ser Arg 
        355                 360                 365             


Tyr Asp Asp Tyr Val Lys Asp Phe Phe Lys Lys Leu Asn Glu Ala Asn 
    370                 375                 380                 


Tyr Lys Ser Leu Asp Asp Tyr Ile Lys Asp Asp Pro Tyr Ser Lys Glu 
385                 390                 395                 400 


Tyr Val Thr Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Thr 
                405                 410                 415     


Ser Ser Gly Glu Thr Ala Asn His Asn Asp Glu Ala Cys Asn Pro Asn 
            420                 425                 430         


Glu Ser Glu Ile Ser Ser Val Gly Gln Ala Pro Ile Ser Asp Pro Ser 
        435                 440                 445             


Ser Asn Lys Thr Cys Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys 
    450                 455                 460                 


Lys Glu Cys Lys His Val Lys Leu Gly Val Arg Glu Asn Asp Lys Val 
465                 470                 475                 480 


Leu Arg Val Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn 
                485                 490                 495     


Cys Cys Cys Gln Asp Leu Leu Gly Met Leu Gln Glu Pro Arg Ile Asp 
            500                 505                 510         


Lys Asn Gln Arg Gly Ser Ser Ser Asn Gly Ser Cys Asp Lys Asn Ser 
        515                 520                 525             


Glu Glu Ile Cys Gln Lys Lys Leu Asp Glu Ala Leu Ala Ser Leu Thr 
    530                 535                 540                 


Asn Gly Tyr Lys Cys Asp Lys Cys Lys Ser Gly Thr Ser Thr Val Asn 
545                 550                 555                 560 


Lys Asn Trp Ile Trp Lys Lys Tyr Ser Gly Lys Glu Gly Gly Leu Gln 
                565                 570                 575     


Glu Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu 
            580                 585                 590         


Cys Leu Val Cys Leu His Glu Lys Glu Gly Lys Thr Gln His Lys Thr 
        595                 600                 605             


Ile Ser Thr Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Asp Ala Phe 
    610                 615                 620                 


His Glu Gly Lys Asn Leu Lys Thr Ser His Gln Asn Lys Asn Ser Gly 
625                 630                 635                 640 


Asn Lys Glu Asn Leu Cys Lys Asp Leu Lys Tyr Ser Phe Ala Asp Tyr 
                645                 650                 655     


Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys 
            660                 665                 670         


Asp Leu Glu Leu Asn Leu Gln Lys Ala Phe Gly Lys Leu Phe Arg Lys 
        675                 680                 685             


Tyr Ile Lys Lys Asn Asn Thr Ala Glu Gln His Thr Ser Tyr Ser Ser 
    690                 695                 700                 


Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile 
705                 710                 715                 720 


Trp Leu Ala Met Lys His Gly Ala Gly Met Asn Gly Thr Thr Cys Cys 
                725                 730                 735     


Gly Asp Gly Ser Val Thr Gly Ser Ser Asp Ser Gly Ser Thr Thr Cys 
            740                 745                 750         


Ser Gly Asp Asn Gly Ser Ile Ser Cys Asp Asp Ile Pro Thr Ile Asp 
        755                 760                 765             


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
    770                 775                 780                 


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Thr Asn Cys Asn 
785                 790                 795                 800 


Ser Cys Lys Asn Thr Ser Ser Lys Thr Lys Leu Gly Gly Thr Cys Asn 
                805                 810                 815     


Ser Asp Cys Glu Lys Lys Cys Lys Asp Glu Cys Glu Lys Tyr Lys Lys 
            820                 825                 830         


Phe Ile Glu Glu Phe Cys Thr Ala Ala Gly Gly Thr Ser Gly Ser Pro 
        835                 840                 845             


Trp Ser Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile 
    850                 855                 860                 


Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly Pro 
865                 870                 875                 880 


Ser Ser Thr Thr Ser Thr Ala Glu Asn Lys Cys Val Gln Ser Asp Ile 
                885                 890                 895     


Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser 
            900                 905                 910         


Ser Tyr Leu Ser Ile Val Leu Asp Glu Asn Asn Cys Gly Glu Asp Asn 
        915                 920                 925             


Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Lys Asn Cys Asp 
    930                 935                 940                 


Ile Gln Lys Lys Thr Pro Lys Ser Gln Ser Cys Asn Thr Ala Val Val 
945                 950                 955                 960 


Val Asn Val Pro Ser Pro Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr 
                965                 970                 975     


Ala Cys Gln Cys Lys Ile Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            980                 985                 990         


Ser Ala Glu Lys Lys Asn Asn Lys  Ser Leu Cys His Glu  Lys Gly Asn 
        995                 1000                 1005             


Asp Arg  Thr Trp Ser Lys Lys  Tyr Ile Lys Lys Leu  Glu Asn Gly 
    1010                 1015                 1020             


Arg Thr  Leu Glu Gly Val Tyr  Val Pro Pro Arg Arg  Gln Gln Leu 
    1025                 1030                 1035             


Cys Leu  Tyr Glu Leu Phe Pro  Ile Ile Ile Lys Asn  Glu Glu Gly 
    1040                 1045                 1050             


Met Glu  Lys Ala Lys Glu Glu  Leu Leu Glu Thr Leu  Gln Ile Ala 
    1055                 1060                 1065             


Ala Glu  Arg Glu Ala Tyr Tyr  Leu Trp Lys Gln Tyr  His Ala His 
    1070                 1075                 1080             


Asn Asp  Thr Thr Tyr Leu Ala  His Lys Lys Ala Cys  Cys Ala Ile 
    1085                 1090                 1095             


Arg Gly  Ser Phe Tyr Asp Leu  Glu Asp Ile Ile Lys  Gly Asn Asp 
    1100                 1105                 1110             


Leu Val  His Asp Glu Tyr Thr  Lys Tyr Ile Asp Ser  Lys Leu Asn 
    1115                 1120                 1125             


Lys Ile  Phe Gly Ser Ser Asn  Lys Asn Asp Ile Glu  Thr Lys Arg 
    1130                 1135                 1140             


Ala Arg  Thr Asp Trp Trp Glu  Asn Glu Ala Ile Gly  Val Ala Asn 
    1145                 1150                 1155             


Gly Thr  Asp His Lys Thr Ile  Arg Gln Leu Val Trp  Asp Ala Met 
    1160                 1165                 1170             


Gln Ser  Gly Val Arg Tyr Ala  Val Glu Glu Lys Lys  Lys Lys Lys 
    1175                 1180                 1185             


Gln Asn  Glu Asn Phe Pro Pro  Cys Met Gly Val Glu  His Ile Gly 
    1190                 1195                 1200             


Ile Ala  Lys Pro Gln Phe Ile  Arg Trp Leu Glu Glu  Trp Thr Asn 
    1205                 1210                 1215             


Glu Phe  Cys Glu Glu Tyr Thr  Lys Tyr Phe Gly Ala  Ile Asn Ser 
    1220                 1225                 1230             


Lys Cys  Asn Leu Arg Lys Gly  Ala Asp Asp Cys Asp  Asp Asn Ser 
    1235                 1240                 1245             


Asn Ile  Glu Cys Lys Arg Ala  Cys Ala Asn Tyr Thr  Asn Trp Leu 
    1250                 1255                 1260             


Asn Pro  Lys Arg Ile Glu Trp  Asn Gly Met Ser Asn  Tyr Tyr Asn 
    1265                 1270                 1275             


Lys Ile  Tyr Arg Lys Ser Asn  Lys Glu Ser Glu Asp  Gly Lys Asp 
    1280                 1285                 1290             


Tyr Ser  Met Ile Met Glu Pro  Thr Val Ile Asp Tyr  Leu Asn Lys 
    1295                 1300                 1305             


Arg Cys  His Gly Glu Ile Asn  Gly Asn Tyr Ile Cys  Cys Ser Cys 
    1310                 1315                 1320             


Lys Asn  Ile Gly Glu Asn Ser  Thr Ser Pro Val Ala  Asn Lys Lys 
    1325                 1330                 1335             


Ala Gln  Arg Lys Asp Glu Gln  Cys Glu Asp Asn Lys  Gly Pro Leu 
    1340                 1345                 1350             


Asp Leu  Met Asn Glu Val Leu  Asn Lys Met Asp Glu  Lys Tyr Ser 
    1355                 1360                 1365             


Glu His  Lys Met 
    1370         


<210>  48
<211>  1364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  48

Met Asp Ser Lys Thr Thr Ile Gly Asp Lys Ile Glu Ala Tyr Leu Glu 
1               5                   10                  15      


Lys Lys Ser Asn Glu Ser Asp Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Arg 
        35                  40                  45              


Lys Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Glu Pro Cys Asp Ser Ile Pro Pro Pro Tyr Gly Asp Ile Asp Glu Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Lys Pro Glu Asn Val 
                85                  90                  95      


Phe Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Asn 
            100                 105                 110         


Leu Asn Val Glu Arg Ile Arg Asp Asn Asn Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Ile Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Lys Asn Ile Leu Glu 
            180                 185                 190         


Lys Gly Ser Thr Ile Gln Ser Asn Tyr Ser Lys Lys Asp Gln Asn Tyr 
        195                 200                 205             


Thr Lys Leu Arg Glu Asp Trp Trp Thr Lys Asn Arg Gln Lys Val Trp 
    210                 215                 220                 


Glu Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg 
225                 230                 235                 240 


Arg Trp Thr Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys Leu Glu Leu 
                245                 250                 255     


Cys Arg Lys Cys Gly His Tyr Glu Gly Lys Val Pro Thr Lys Leu Asp 
            260                 265                 270         


Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe 
        275                 280                 285             


Tyr Arg Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His Arg Glu 
    290                 295                 300                 


Glu Cys Thr Arg Glu Asp His Lys Ser Lys Glu Gly Ala Ser Tyr Cys 
305                 310                 315                 320 


Ser Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys 
                325                 330                 335     


Trp Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Lys Asp Leu Tyr 
            340                 345                 350         


Gln Gln Glu Asn Glu Thr Ser Ser Ser Ser Lys Lys Lys Ser Arg Tyr 
        355                 360                 365             


Asp Asp Tyr Val Lys Glu Phe Phe Lys Asn Phe Lys Gly Asp Asn Tyr 
    370                 375                 380                 


Lys Ser Leu Asp Asp Tyr Ile Lys Gly Asp Pro Tyr Ser Lys Glu Tyr 
385                 390                 395                 400 


Thr Thr Lys Leu Ser Phe Ile Leu Asn Pro Ser Asp Ala Asn Thr Ser 
                405                 410                 415     


Ser Glu Lys Ile Gln Lys Asn Asn Asp Glu Ala Cys Asn Cys Asn Glu 
            420                 425                 430         


Ser Glu Ile Ala Ser Val Glu Gln Ala Ser Ile Ser Asp Arg Ser Ser 
        435                 440                 445             


Gln Lys Ala Tyr Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys 
    450                 455                 460                 


Val Cys Lys His Val Lys Leu Gly Val Arg Glu Asn Asp Lys Val Leu 
465                 470                 475                 480 


Arg Val Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Glu Asn Cys 
                485                 490                 495     


Cys Phe Lys Asp Phe Leu Arg Ile Val Glu Glu Pro Arg Ile Asp Lys 
            500                 505                 510         


Asn Gln Arg Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Asn Asn Glu 
        515                 520                 525             


Glu Ala Cys Glu Lys Asn Leu Asp Glu Ala Leu Ala Ser Leu Thr Asn 
    530                 535                 540                 


Cys Tyr Lys Cys Asp Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn 
545                 550                 555                 560 


Asn Lys Trp Ile Trp Arg Lys Phe Pro Gly Asn Gly Glu Gly Leu Gln 
                565                 570                 575     


Lys Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu 
            580                 585                 590         


Cys Leu Val Cys Leu His Glu Lys Glu Gly Lys Thr Gln Glu Leu Lys 
        595                 600                 605             


Asn Ile Arg Thr Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Asp Ala 
    610                 615                 620                 


Phe His Glu Gly Lys Asn Leu Lys Thr Ser His Gln Lys Lys Asn Ala 
625                 630                 635                 640 


Glu Asn Lys Lys Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp 
                645                 650                 655     


Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr 
            660                 665                 670         


Lys Asp Leu Glu Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg 
        675                 680                 685             


Lys Tyr Ile Lys Lys Asn Ile Ser Thr Glu Gln His Thr Ser Tyr Ser 
    690                 695                 700                 


Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr 
705                 710                 715                 720 


Ile Trp Thr Ala Met Lys His Gly Ala Glu Met Asn Ser Thr Met Cys 
                725                 730                 735     


Asn Val Asp Gly Ser Val Thr Gly Ser Ser Asp Ser Gly Ser Thr Thr 
            740                 745                 750         


Cys Ser Gly Asp Asn Gly Ser Ile Ser Cys Asp Asp Ile Pro Thr Ile 
        755                 760                 765             


Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His 
    770                 775                 780                 


Phe Cys Lys Gln Arg Gln Ala Lys Val Asn Ala Val Ile Lys Asn Cys 
785                 790                 795                 800 


Asn Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Asp Cys Lys Thr 
                805                 810                 815     


Lys Cys Lys Val Ala Cys Asp Ala Tyr Lys Lys Phe Ile Glu Glu Cys 
            820                 825                 830         


Arg Thr Ala Ala Glu Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp 
        835                 840                 845             


Tyr Gln Ile Tyr Met Arg Tyr Ser Lys His Ile Glu Asp Ala Lys Arg 
    850                 855                 860                 


Asn Arg Lys Ala Gly Thr Lys Ser Cys Gly Thr Ser Thr Ala Glu Ser 
865                 870                 875                 880 


Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp 
                885                 890                 895     


Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Asn Val Leu Asp Glu 
            900                 905                 910         


Asn Asn Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr 
        915                 920                 925             


Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Lys Asn Cys Asp Ile Gln Lys 
    930                 935                 940                 


Asp Lys Ser Lys Ser Gln Ser Cys Asn Thr Ala Val Val Val Asn Val 
945                 950                 955                 960 


Pro Ser Pro Leu Gly Asn Thr Pro Tyr Glu Tyr Lys Tyr Ala Cys Glu 
                965                 970                 975     


Cys Lys Ile Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
            980                 985                 990         


Gly Gln Ser Asn Lys Ser Leu Cys  His Glu Lys Gly Asn  Asp Arg Thr 
        995                 1000                 1005             


Trp Ser  Lys Lys Tyr Ile Lys  Lys Leu Glu Asn Gly  Arg Thr Leu 
    1010                 1015                 1020             


Glu Gly  Val Tyr Val Pro Pro  Arg Arg Gln Gln Leu  Cys Leu Tyr 
    1025                 1030                 1035             


Glu Leu  Phe Pro Ile Ile Ile  Lys Lys Glu Lys Asp  Met Glu Asn 
    1040                 1045                 1050             


Val Lys  Lys Glu Leu Leu Glu  Thr Leu Gln Ile Val  Ala Glu Arg 
    1055                 1060                 1065             


Glu Ala  Tyr Tyr Leu Trp Lys  Gln Tyr Asn Pro Thr  Gly Lys Gly 
    1070                 1075                 1080             


Ile Asp  Asp Ala Asn Lys Lys  Ala Cys Cys Ala Ile  Arg Gly Ser 
    1085                 1090                 1095             


Phe Tyr  Asp Leu Glu Asp Ile  Ile Lys Gly Asn Asp  Leu Val His 
    1100                 1105                 1110             


Asp Glu  Tyr Thr Lys Tyr Ile  Asp Ser Lys Leu Asn  Glu Ile Phe 
    1115                 1120                 1125             


Gly Ser  Ser Asn Lys Asn Asp  Ile Glu Thr Lys Arg  Ala Arg Thr 
    1130                 1135                 1140             


Asp Trp  Trp Glu Asn Glu Thr  Ile Thr Asn Arg Thr  Asp Arg Lys 
    1145                 1150                 1155             


Thr Ile  Arg Gln Leu Val Trp  Asp Ala Met Gln Ser  Gly Val Arg 
    1160                 1165                 1170             


Tyr Ala  Val Glu Glu Lys Asn  Glu Asn Phe Pro Pro  Cys Met Gly 
    1175                 1180                 1185             


Val Glu  His Ile Gly Ile Ala  Lys Pro Gln Phe Ile  Arg Trp Leu 
    1190                 1195                 1200             


Glu Glu  Trp Thr Asn Glu Phe  Cys Glu Glu Tyr Thr  Lys Tyr Phe 
    1205                 1210                 1215             


Glu Asp  Met Lys Ser Lys Cys  Asp Leu Arg Lys Gly  Ala Asp Asp 
    1220                 1225                 1230             


Cys Gly  Asp Asn Thr Asn Ile  Glu Cys Lys Arg Ala  Cys Ala Asn 
    1235                 1240                 1245             


Tyr Thr  Asn Trp Leu Asn Pro  Lys Arg Ile Glu Trp  Asn Gly Met 
    1250                 1255                 1260             


Ser Asn  Tyr Tyr Asn Lys Ile  Tyr Arg Lys Ser Asn  Lys Glu Ser 
    1265                 1270                 1275             


Glu Asp  Gly Lys Asp Tyr Ser  Met Ile Met Glu Pro  Thr Val Ile 
    1280                 1285                 1290             


Asp Tyr  Leu Asn Lys Arg Cys  Asn Gly Glu Ile Asn  Gly Asn Tyr 
    1295                 1300                 1305             


Ile Cys  Cys Ser Cys Lys Asn  Ile Gly Glu Asn Tyr  Asn Pro Ser 
    1310                 1315                 1320             


Pro Ala  Gln Lys Thr Lys Gly  Ser Lys Lys Lys Asp  Glu Gln Cys 
    1325                 1330                 1335             


Glu Asp  Asn Lys Gly Pro Leu  Asp Leu Met Asn Glu  Val Leu Asn 
    1340                 1345                 1350             


Lys Met  Asp Pro Lys Tyr Ser  Lys Leu Asn Leu 
    1355                 1360                 


<210>  49
<211>  1388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  49

Met Asp Ser Thr Ser Thr Ile Ala Asn Lys Ile Glu Glu Tyr Leu Lys 
1               5                   10                  15      


Glu Lys Ser Asn Glu Ser Asp Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Arg 
        35                  40                  45              


Lys Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Asp Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Asp Glu Asn Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Asn 
            100                 105                 110         


Leu Asn Val Glu Arg Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Ile Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Lys Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu 
            180                 185                 190         


Asn Asp Lys Val Leu Gln Asp Lys Tyr Pro Asn Asp Asp Pro Lys Tyr 
        195                 200                 205             


Thr Lys Leu Arg Glu Gly Trp Trp Asn Ala Asn Arg Gln Lys Val Trp 
    210                 215                 220                 


Glu Val Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg 
225                 230                 235                 240 


Arg Trp Thr Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys Leu Glu Leu 
                245                 250                 255     


Cys Arg Lys Cys Gly His Tyr Glu Gly Lys Val Pro Thr Tyr Leu Asp 
            260                 265                 270         


Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe 
        275                 280                 285             


Tyr Arg Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His Arg Glu 
    290                 295                 300                 


Glu Cys Thr Arg Glu Asp Asp Lys Cys Lys Glu Gly Ala Ser Tyr Cys 
305                 310                 315                 320 


Ser Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys 
                325                 330                 335     


Trp Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr 
            340                 345                 350         


Glu Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp 
        355                 360                 365             


Asn Tyr Val Lys Asp Phe Phe Glu Lys Leu Glu Ala Asn Tyr Lys Ser 
    370                 375                 380                 


Leu Asp Asp Tyr Ile Lys Asp Asp Pro Tyr Phe Ala Glu Tyr Ala Thr 
385                 390                 395                 400 


Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Gly 
                405                 410                 415     


Glu Thr Ala Asn His Asn Asp Glu Val Cys Asn Pro Asn Glu Ser Glu 
            420                 425                 430         


Ile Ser Ser Val Gly Gln Ala Gln Thr Ser Gly Pro Ser Ser Asn Lys 
        435                 440                 445             


Thr Cys Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Val Cys 
    450                 455                 460                 


Lys Tyr Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Lys Ile 
465                 470                 475                 480 


Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys 
                485                 490                 495     


Gln Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Asn Asn Glu Glu Ala Cys 
        515                 520                 525             


Glu Lys Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Asn Gln Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Asn Lys Trp 
545                 550                 555                 560 


Ile Trp Lys Lys Ser Ser Gly Asn Gly Glu Gly Leu Gln Lys Glu Tyr 
                565                 570                 575     


Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Tyr Leu Gly 
            580                 585                 590         


Asn Leu Arg Lys Leu Gly Asn Val Cys Glu Asp Val Lys Asp Ile Asn 
        595                 600                 605             


Phe Asp Thr Lys Glu Lys Phe Leu Ala Gly Cys Leu Ile Ala Ala Phe 
    610                 615                 620                 


His Glu Gly Lys Asn Leu Lys Thr Thr Tyr Leu Glu Lys Lys Lys Gly 
625                 630                 635                 640 


Asp Asn Gly Lys Lys Leu Cys Lys Asp Leu Lys Tyr Ser Phe Ala Asp 
                645                 650                 655     


Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Asp Phe Thr 
            660                 665                 670         


Lys Asn Val Glu Leu Asn Leu Gln Gln Ile Phe Gly Lys Leu Phe Arg 
        675                 680                 685             


Lys Tyr Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser 
    690                 695                 700                 


Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr 
705                 710                 715                 720 


Ile Trp Leu Ala Met Lys His Gly Ala Gly Met Asn Gly Thr Thr Cys 
                725                 730                 735     


Ser Ser Gly Ser Gly Asp Asn Gly Asp Ser Ser Ile Thr Gly Ser Ser 
            740                 745                 750         


Asp Ser Gly Ser Thr Thr Cys Ser Gly Asp Asn Gly Ser Ile Ser Cys 
        755                 760                 765             


Asp Asp Ile Pro Thr Ile Asp Phe Ile Pro Gln Tyr Leu Arg Phe Leu 
    770                 775                 780                 


Gln Glu Trp Val Glu Asn Phe Cys Glu Gln Arg Gln Ala Lys Val Asn 
785                 790                 795                 800 


Ala Val Ile Asn Ser Cys Asn Ser Cys Lys Asn Thr Ser Gly Glu Arg 
                805                 810                 815     


Lys Ile Gly Asp Thr Cys Asn Ser Asp Cys Lys Thr Glu Cys Lys Asn 
            820                 825                 830         


Lys Cys Glu Ala Tyr Lys Thr Phe Ile Asp Asn Val Gly Asp Gly Thr 
        835                 840                 845             


Ala Gly Ser Pro Trp Val Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr 
    850                 855                 860                 


Ser Lys His Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys 
865                 870                 875                 880 


Asn Cys Gly Ile Thr Thr Gly Thr Ile Ser Gly Glu Ser Ser Gly Ala 
                885                 890                 895     


Thr Ser Gly Val Thr Thr Thr Glu Asn Lys Cys Val Gln Ser Asp Ile 
            900                 905                 910         


Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser 
        915                 920                 925             


Ser Tyr Leu Ser Ile Val Leu Asp Glu Asn Asn Cys Gly Glu Asp Lys 
    930                 935                 940                 


Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Tyr Thr Thr Tyr Thr 
945                 950                 955                 960 


Thr Thr Lys Asn Cys Asp Ile Gln Lys Asp Lys Ser Lys Leu Gln Gln 
                965                 970                 975     


Ser Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly Asn Thr 
            980                 985                 990         


Pro His Glu Tyr Lys Tyr Ala Cys  Gln Cys Lys Ile Pro  Gly Gly Gly 
        995                 1000                 1005             


Gly Ser  Gly Gly Gly Gly Ser  Asp Lys Gly Gln Asn  Asn Lys Ser 
    1010                 1015                 1020             


Leu Cys  His Glu Lys Gly Asn  Asp Arg Thr Trp Ser  Lys Lys Tyr 
    1025                 1030                 1035             


Ile Lys  Lys Leu Glu Asn Gly  Arg Ser Leu Glu Gly  Val Tyr Val 
    1040                 1045                 1050             


Pro Pro  Arg Arg Gln Gln Leu  Cys Leu Tyr Glu Leu  Phe Pro Ile 
    1055                 1060                 1065             


Ile Ile  Lys Lys Glu Lys Asp  Met Glu Lys Ala Lys  Glu Glu Leu 
    1070                 1075                 1080             


Leu Glu  Thr Leu Lys Ile Val  Ala Glu Arg Glu Ala  Tyr Tyr Leu 
    1085                 1090                 1095             


Trp Lys  Gln Tyr His Ala His  Asn Asp Thr Thr Tyr  Leu Ala His 
    1100                 1105                 1110             


Lys Lys  Ala Cys Cys Ala Ile  Arg Gly Ser Phe Tyr  Asp Leu Glu 
    1115                 1120                 1125             


Asp Ile  Ile Lys Gly Asn Asp  Leu Val His Asp Glu  Tyr Thr Lys 
    1130                 1135                 1140             


Tyr Ile  Asp Ser Lys Leu Asn  Glu Ile Phe Gly Ser  Ser Asn Thr 
    1145                 1150                 1155             


Asn Asn  Ile Asp Thr Lys Arg  Ala Arg Thr Asp Trp  Trp Glu Asn 
    1160                 1165                 1170             


Glu Thr  Ile Thr Asn Gly Pro  Asp Arg Lys Thr Ile  Arg Gln Leu 
    1175                 1180                 1185             


Val Trp  Asp Ala Met Gln Ser  Gly Val Arg Tyr Ala  Val Glu Glu 
    1190                 1195                 1200             


Lys Lys  Glu Asn Phe Pro Pro  Cys Met Gly Val Glu  His Ile Gly 
    1205                 1210                 1215             


Ile Ala  Lys Pro Gln Phe Ile  Arg Trp Leu Glu Glu  Trp Thr Asn 
    1220                 1225                 1230             


Glu Phe  Cys Glu Glu Tyr Thr  Lys Tyr Phe Glu Asp  Met Lys Ser 
    1235                 1240                 1245             


Lys Cys  Asp Pro Pro Lys Ser  Ala Asp Asp Cys Gly  Asp Asn Thr 
    1250                 1255                 1260             


Asn Ile  Glu Cys Lys Lys Ala  Cys Ala Asn Tyr Thr  Asn Trp Leu 
    1265                 1270                 1275             


Asn Pro  Lys Arg Ile Glu Trp  Asn Gly Met Ser Asn  Tyr Tyr Asn 
    1280                 1285                 1290             


Lys Ile  Tyr Arg Lys Ser Asn  Lys Glu Ser Glu Asp  Gly Lys Asp 
    1295                 1300                 1305             


Tyr Ser  Met Ile Met Glu Pro  Thr Val Ile Asp Tyr  Leu Asn Lys 
    1310                 1315                 1320             


Arg Cys  Asn Gly Glu Ile Asn  Gly Asn Tyr Ile Cys  Cys Ser Cys 
    1325                 1330                 1335             


Lys Asn  Ile Gly Ala Tyr Asn  Thr Thr Ser Gly Thr  Val Asn Lys 
    1340                 1345                 1350             


Lys Leu  Gln Lys Lys Glu Thr  Glu Cys Glu Asp Asn  Lys Gly Pro 
    1355                 1360                 1365             


Leu Asp  Leu Met Asn Glu Val  Leu Asn Lys Met Asp  Glu Lys Tyr 
    1370                 1375                 1380             


Ser Ala  His Lys Met 
    1385             


<210>  50
<211>  1349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  50

Met Asp Lys Ser Ser Ile Gly Asp Lys Ile Glu Ala Tyr Leu Glu Lys 
1               5                   10                  15      


Lys Ser Asn Glu Ser Asp Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys Asn 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Ile Asp Glu Trp Lys 
65                  70                  75                  80  


Cys Gln Gln Asn Ser Ser Asp Gly Ser Gly Lys Pro Glu Asn Ile Cys 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
            100                 105                 110         


Lys Phe Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
                165                 170                 175     


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Leu Glu Lys 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Thr Lys 
        195                 200                 205             


Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
    210                 215                 220                 


Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Arg Trp 
225                 230                 235                 240 


Thr Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
                245                 250                 255     


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Tyr Leu Asp Tyr Val 
            260                 265                 270         


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Ala Asp Leu Tyr Arg 
        275                 280                 285             


Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His Arg Glu Glu Cys 
    290                 295                 300                 


Thr Arg Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Asn Met 
305                 310                 315                 320 


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
                325                 330                 335     


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Lys Asp Leu Tyr Glu Gln 
            340                 345                 350         


Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
        355                 360                 365             


Val Lys Glu Phe Phe Lys Lys Leu Glu Ala Asn Tyr Lys Ser Leu Asp 
    370                 375                 380                 


Asp Tyr Ile Lys Asp Asp Pro Tyr Ser Lys Glu Tyr Val Thr Lys Leu 
385                 390                 395                 400 


Ser Phe Ile Pro Asn Ser Ser Asp Thr Glu Asn Ala Ser Glu Lys Ile 
                405                 410                 415     


Gln Lys Asn Asn Asp Glu Val Cys Asn Pro Asn Glu Ser Gly Ile Ser 
            420                 425                 430         


Ser Val Gly Gln Ala Gln Thr Ser Gly Thr Ser Ser Asn Lys Thr Cys 
        435                 440                 445             


Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Val Cys Lys His 
    450                 455                 460                 


Val Lys Leu Gly Ile Asn Asn Asn Asp Lys Val Leu Arg Val Cys Val 
465                 470                 475                 480 


Ile Glu Asp Asp Ser Leu Arg Gly Val Asp Asn Cys Cys Cys Gln Asp 
                485                 490                 495     


Phe Leu Arg Met Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg Gly Ser 
            500                 505                 510         


Ser Ser Asn Asp Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
        515                 520                 525             


Asn Leu Asp Glu Ala Leu Ala Ser Leu Thr Asn Gly Tyr Lys Cys Asp 
    530                 535                 540                 


Lys Cys Lys Ser Gly Thr Ser Thr Val Asn Lys Asn Trp Ile Trp Arg 
545                 550                 555                 560 


Lys Ser Ser Gly Asn Lys Glu Gly Leu Gln Lys Glu Tyr Ala Asn Thr 
                565                 570                 575     


Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Cys Leu His 
            580                 585                 590         


Glu Lys Glu Gly Lys Thr Gln Glu Leu Lys Asn Ile Ser Thr Asn Ser 
        595                 600                 605             


Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly Lys Asn 
    610                 615                 620                 


Leu Lys Thr Thr Tyr Pro Gln Asn Lys Asn Ala Glu Asn Lys Lys Lys 
625                 630                 635                 640 


Leu Cys Lys Ala Leu Lys Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile 
                645                 650                 655     


Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu Leu 
            660                 665                 670         


Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys Lys 
        675                 680                 685             


Asn Asn Thr Ala Glu Gln His Thr Ser Tyr Ser Ser Leu Asp Glu Leu 
    690                 695                 700                 


Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Thr Ala Met 
705                 710                 715                 720 


Lys His Gly Ala Gly Met Asn Gly Thr Thr Cys Ser Ser Gly Ser Gly 
                725                 730                 735     


Asp Asn Gly Ser Ile Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu Ile 
            740                 745                 750         


Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe Cys Glu 
        755                 760                 765             


Gln Arg Gln Gly Lys Val Lys Asp Val Ile Thr Asn Cys Lys Ser Cys 
    770                 775                 780                 


Lys Glu Ser Gly Asp Thr Cys Lys Thr Glu Cys Lys Thr Lys Cys Lys 
785                 790                 795                 800 


Asp Glu Cys Glu Lys Tyr Lys Thr Phe Ile Glu Asp Cys Asn Gly Gly 
                805                 810                 815     


Gly Thr Gly Thr Ala Gly Ser Ser Trp Ser Lys Arg Trp Asp Gln Ile 
            820                 825                 830         


Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys 
        835                 840                 845             


Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Ser Thr Ala Glu 
    850                 855                 860                 


Ser Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile 
865                 870                 875                 880 


Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp 
                885                 890                 895     


Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr 
            900                 905                 910         


Tyr Thr Thr Thr Glu Asn Cys Asp Ile Gln Lys Lys Thr Pro Lys Ser 
        915                 920                 925             


Gln Ser Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly 
    930                 935                 940                 


Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Glu Cys Lys Ile Pro Gly 
945                 950                 955                 960 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Lys Lys Asn Asn Lys 
                965                 970                 975     


Ser Leu Cys His Glu Lys Gly Asn Asp Arg Thr Trp Ser Lys Lys Tyr 
            980                 985                 990         


Ile Lys Lys Leu Glu Asn Gly Arg  Ser Leu Glu Gly Val  Tyr Val Pro 
        995                 1000                 1005             


Pro Arg  Arg Gln Gln Leu Cys  Leu Tyr Glu Leu Phe  Pro Ile Ile 
    1010                 1015                 1020             


Ile Lys  Lys Glu Lys Asp Met  Glu Asn Val Lys Lys  Glu Leu Leu 
    1025                 1030                 1035             


Glu Thr  Leu Gln Ile Val Ala  Glu Arg Glu Ala Tyr  Tyr Leu Trp 
    1040                 1045                 1050             


Lys Gln  Tyr Asn Pro Thr Gly  Lys Gly Ile Asp Asp  Ala Asn Lys 
    1055                 1060                 1065             


Lys Ala  Cys Cys Ala Ile Arg  Gly Ser Phe Tyr Asp  Leu Glu Asp 
    1070                 1075                 1080             


Ile Ile  Lys Gly Asn Asp Leu  Val His Asp Glu Tyr  Thr Lys Tyr 
    1085                 1090                 1095             


Ile Asp  Ser Lys Leu Asn Glu  Ile Phe Gly Ser Ser  Asn Lys Asn 
    1100                 1105                 1110             


Asp Ile  Asp Thr Lys Arg Ala  Arg Thr Asp Trp Trp  Glu Asn Glu 
    1115                 1120                 1125             


Thr Phe  Gln Val Ser Asn Ile  Thr Gly Ala Asn Lys  Ser Asp Pro 
    1130                 1135                 1140             


Lys Thr  Ile Arg Gln Leu Val  Trp Asp Ala Met Gln  Ser Gly Val 
    1145                 1150                 1155             


Arg Tyr  Ala Val Glu Glu Lys  Asn Glu Asn Phe Pro  Pro Cys Met 
    1160                 1165                 1170             


Gly Val  Glu His Ile Gly Ile  Ala Lys Pro Gln Phe  Ile Arg Trp 
    1175                 1180                 1185             


Leu Glu  Glu Trp Thr Asn Glu  Phe Cys Glu Lys Tyr  Thr Lys Tyr 
    1190                 1195                 1200             


Phe Glu  Asp Met Lys Ser Asn  Cys Asn Arg Arg Lys  Gly Ala Asp 
    1205                 1210                 1215             


Thr Cys  Gly Asp Asn Ser Asn  Ile Glu Cys Lys Arg  Ala Cys Ala 
    1220                 1225                 1230             


Asn Tyr  Thr Asn Trp Leu Asn  Pro Lys Arg Ile Glu  Trp Asn Gly 
    1235                 1240                 1245             


Met Ser  Asn Tyr Tyr Asn Lys  Ile Tyr Arg Lys Ser  Asn Lys Glu 
    1250                 1255                 1260             


Ser Glu  Asp Gly Lys Asp Tyr  Ser Met Ile Met Glu  Pro Thr Val 
    1265                 1270                 1275             


Ile Asp  Tyr Leu Asn Lys Arg  Cys His Gly Glu Ile  Asn Gly Asn 
    1280                 1285                 1290             


Tyr Ile  Cys Cys Ser Cys Lys  Asn Ile Gly Glu Tyr  Asn Ser Thr 
    1295                 1300                 1305             


Ser Gly  Thr Val Asn Lys Lys  Leu Gln Lys Lys Glu  Thr Glu Cys 
    1310                 1315                 1320             


Glu Glu  Glu Lys Gly Pro Leu  Asp Leu Met Asn Glu  Val Leu Asn 
    1325                 1330                 1335             


Lys Met  Asp Glu Lys Tyr Ser  Ala His Lys Met 
    1340                 1345                 


<210>  51
<211>  1370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  51

Met Asp Lys Ser Ser Ile Ala Asn Lys Ile Glu Glu Tyr Leu Lys Glu 
1               5                   10                  15      


Lys Ser Asp Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys Asn 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Glu Lys Lys Leu Leu Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Asp Glu Asn Leu Ser Lys Val Ser Gly Lys Pro Glu Asn Ile Cys 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
            100                 105                 110         


Lys Phe Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Lys Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Leu Ala Asp Ile Ile Arg Gly Arg Asp Gly Asn Lys Cys Glu Thr Lys 
                165                 170                 175     


Ser Pro Asn Asn Val Glu Glu Leu Ile Lys Lys Phe Phe Glu Lys Asn 
            180                 185                 190         


Tyr Arg Ser Asn Glu Glu Tyr Arg Lys Lys Tyr Pro Asn Asp Asp Glu 
        195                 200                 205             


Asn Tyr Lys Lys Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys 
    210                 215                 220                 


Val Trp Glu Val Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile 
225                 230                 235                 240 


Lys Arg Arg Trp Arg Thr Ser Lys Glu Ser Asn Gly Glu Asn Lys Leu 
                245                 250                 255     


Glu Leu Cys Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Lys 
            260                 265                 270         


Leu Asp Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu 
        275                 280                 285             


Asp Phe Tyr Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His 
    290                 295                 300                 


Arg Glu Glu Cys Thr Arg Glu Asp Asp Lys Cys Lys Glu Gly Thr Ser 
305                 310                 315                 320 


Tyr Cys Asn Met Cys Lys Glu Lys His Thr Lys Tyr Cys Glu Cys Val 
                325                 330                 335     


Lys Lys Trp Lys Thr Glu Trp Glu Asn Gln Glu Asn Lys Tyr Thr Glu 
            340                 345                 350         


Leu Tyr Glu Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg 
        355                 360                 365             


Tyr Asp Asp Asn Val Lys Glu Phe Phe Glu Lys Leu Lys Gly Asn Gly 
    370                 375                 380                 


Tyr Ser Ser Ala Asn Ser Tyr Val Lys Asn Asn Pro Tyr Ser Ser Glu 
385                 390                 395                 400 


Asp Gly Lys Leu Leu Lys Phe Asp Asn Thr Asn Ala Phe Lys Glu Ser 
                405                 410                 415     


Ile Thr Cys Asn Lys Asn Val Cys Ser Cys Ser Gly Asn Glu Lys Leu 
            420                 425                 430         


Ile Ile Ser Glu Gly Ser Leu Ser Ser Ser Ser Phe Gly Thr Ser Ser 
        435                 440                 445             


Ser Tyr Gln Ser Ser Ile Ile Thr Ser Lys Lys Arg Asn Glu Cys Ala 
    450                 455                 460                 


Gln Ile Lys Phe Ser Gly Asn Glu Asn Asn Met Asn Ile Lys Ile Cys 
465                 470                 475                 480 


Ser Thr Gln Asp Asn Asn Leu Leu Val Lys Leu Glu Asp Leu Leu Lys 
                485                 490                 495     


Gly Phe Cys Asp Thr Cys Asp Thr Gly Ile Gly Val Glu Val Val Ser 
            500                 505                 510         


Glu Asn Asn Cys Glu Glu Gln Tyr Lys Lys Leu Leu Pro Ser Leu Glu 
        515                 520                 525             


Lys Cys Thr Val Leu Asn Cys Asn Glu Cys Asn Lys Thr Val Phe Lys 
    530                 535                 540                 


Asn Leu Lys Lys Gln Gln Glu Lys Trp Ile Trp Gly Lys Pro Lys Gln 
545                 550                 555                 560 


Glu Ala Ala Gly Leu Gln Glu Glu Tyr Ala Asn Thr Ile Gly Leu Pro 
                565                 570                 575     


Pro Arg Thr Gln Leu Leu Tyr Leu Val Cys Leu His Glu Lys Glu Gly 
            580                 585                 590         


Lys Thr Gln Glu Leu Lys Asn Ile Ser Thr Asn Ser Glu Leu Leu Lys 
        595                 600                 605             


Glu Trp Ile Ile Ala Ala Phe His Glu Gly Lys Asn Leu Lys Pro Ser 
    610                 615                 620                 


His Gln Asn Lys Asn Asp Asp Asn Gly Lys Lys Leu Cys Lys Asp Leu 
625                 630                 635                 640 


Lys Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile 
                645                 650                 655     


Trp Asp Asn Asp Phe Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ile 
            660                 665                 670         


Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys Lys Asn Ile Ser Thr Glu 
        675                 680                 685             


Gln Asp Thr Leu Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp 
    690                 695                 700                 


Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala Met Lys His Gly Ala Gly 
705                 710                 715                 720 


Met Asn Ser Thr Thr Cys Asn Gly Asp Gly Ser Val Thr Gly Ser Ser 
                725                 730                 735     


Asp Ser Gly Ser Thr Thr Cys Ser Gly Asp Asn Gly Ser Ile Ser Cys 
            740                 745                 750         


Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu 
        755                 760                 765             


Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg Gln Glu Lys Val Asn 
    770                 775                 780                 


Ala Val Ile Thr Asn Cys Lys Ser Cys Lys Asn Thr Ser Gly Glu Arg 
785                 790                 795                 800 


Lys Ile Gly Asp Thr Cys Gly Asn Asp Cys Glu Lys Lys Cys Lys Val 
                805                 810                 815     


Ala Cys Asp Ala Tyr Lys Glu Phe Ile Glu Glu Cys Arg Thr Ala Ala 
            820                 825                 830         


Glu Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln Ile Tyr 
        835                 840                 845             


Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala 
    850                 855                 860                 


Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala Glu Ser 
865                 870                 875                 880 


Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp 
                885                 890                 895     


Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp Glu 
            900                 905                 910         


Asn Asn Cys Gly Glu Asp Asn Ala Pro Trp Thr Thr Tyr Thr Thr Tyr 
        915                 920                 925             


Thr Thr Thr Lys Asn Cys Asp Ile Gln Lys Asp Lys Ser Lys Ser Gln 
    930                 935                 940                 


Ser Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
945                 950                 955                 960 


Thr Pro His Gly Tyr Lys Tyr Ala Cys Glu Cys Arg Thr Pro Gly Gly 
                965                 970                 975     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Gly Gln Asn Asn Lys Ser 
            980                 985                 990         


Leu Cys His Glu Lys Gly Asn Asp  Arg Thr Trp Ser Lys  Lys Tyr Ile 
        995                 1000                 1005             


Lys Lys  Leu Glu Asn Gly Arg  Ser Leu Glu Gly Val  Tyr Val Pro 
    1010                 1015                 1020             


Pro Gly  Arg Gln Gln Leu Cys  Leu Tyr Glu Leu Phe  Pro Ile Ile 
    1025                 1030                 1035             


Ile Lys  Asn Glu Glu Gly Met  Glu Lys Ala Lys Lys  Glu Leu Leu 
    1040                 1045                 1050             


Glu Thr  Leu Gln Ile Val Ala  Glu Arg Glu Ala Tyr  Tyr Leu Trp 
    1055                 1060                 1065             


Lys Gln  Tyr His Ala His Asn  Asp Thr Thr Tyr Leu  Ala His Lys 
    1070                 1075                 1080             


Lys Ala  Cys Cys Ala Ile Arg  Gly Ser Phe Tyr Asp  Leu Glu Asp 
    1085                 1090                 1095             


Ile Ile  Lys Gly Asn Asp Leu  Val His Asp Glu Tyr  Thr Lys Tyr 
    1100                 1105                 1110             


Ile Asp  Ser Lys Leu Asn Lys  Ile Phe Gly Ser Ser  Asn Thr Asn 
    1115                 1120                 1125             


Asn Ile  Glu Thr Lys Arg Ala  Arg Thr Asp Trp Trp  Glu Asn Lys 
    1130                 1135                 1140             


Thr Ile  Asp Val Pro Asn Ile  Thr Asp Ala Asn Lys  Ser Asp Ser 
    1145                 1150                 1155             


Lys Thr  Ile Arg Gln Leu Val  Trp Asp Ala Met Gln  Ser Gly Val 
    1160                 1165                 1170             


Arg Lys  Ala Ile Asp Glu Glu  Asn Glu Lys Lys Lys  Pro Asn Glu 
    1175                 1180                 1185             


Asn Phe  Pro Pro Cys Met Gly  Val Glu His Ile Gly  Ile Ala Lys 
    1190                 1195                 1200             


Pro Gln  Phe Ile Arg Trp Leu  Glu Glu Trp Thr Asn  Glu Phe Cys 
    1205                 1210                 1215             


Glu Lys  Tyr Thr Lys Tyr Phe  Glu Asp Met Lys Ser  Asn Cys Asp 
    1220                 1225                 1230             


Pro Pro  Lys Ser Ala Asp Asp  Cys Gly Asp Asn Thr  Asn Ile Glu 
    1235                 1240                 1245             


Cys Lys  Lys Ala Cys Ala Asn  Tyr Thr Asn Trp Leu  Asn Pro Lys 
    1250                 1255                 1260             


Arg Ile  Glu Trp Asn Gly Met  Ser Asn Tyr Tyr Asn  Lys Ile Tyr 
    1265                 1270                 1275             


Arg Lys  Ser Asn Lys Glu Ser  Glu Asp Gly Lys Asp  Tyr Ser Met 
    1280                 1285                 1290             


Ile Met  Glu Pro Thr Val Ile  Asp Tyr Leu Asn Lys  Arg Cys His 
    1295                 1300                 1305             


Gly Glu  Ile Asn Gly Asn Tyr  Ile Cys Cys Ser Cys  Lys Asn Ile 
    1310                 1315                 1320             


Gly Ala  Tyr Asn Thr Thr Ser  Gly Thr Val Asn Lys  Lys Leu Gln 
    1325                 1330                 1335             


Lys Lys  Glu Thr Glu Cys Glu  Asp Asn Lys Gly Pro  Leu Asp Leu 
    1340                 1345                 1350             


Met Asn  Glu Val Leu Asn Lys  Met Asp Pro Lys Tyr  Ser Lys Leu 
    1355                 1360                 1365             


Asn Leu  
    1370 


<210>  52
<211>  1380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  52

Met Asp Ser Thr Ser Thr Ile Ala Asp Lys Ile Glu Glu Tyr Leu Glu 
1               5                   10                  15      


Lys Lys Ser Asp Glu Ser Asn Ile Glu Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Glu Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Gly Asn His Lys Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys 
            100                 105                 110         


Leu Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Arg Asp Glu Asn Lys Cys Glu Thr 
                165                 170                 175     


Lys Ser Thr Asn Asn Val Glu Glu Leu Ile Lys Asn Phe Phe Gly Lys 
            180                 185                 190         


Asn Tyr Arg Ser Asn Glu Glu Tyr Lys Arg Lys Tyr Arg Asn Asp Asp 
        195                 200                 205             


Pro Lys Tyr Thr Lys Leu Arg Glu Ser Trp Trp Thr Lys Asn Arg Gln 
    210                 215                 220                 


Lys Val Trp Glu Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu 
225                 230                 235                 240 


Ile Lys Arg Gly Trp Arg Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys 
                245                 250                 255     


Leu Glu Leu Phe Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr 
            260                 265                 270         


Lys Leu Asp Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile 
        275                 280                 285             


Glu Asp Leu Tyr Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg 
    290                 295                 300                 


His Arg Glu Glu Cys Thr Ser Glu Asp Asp Lys Cys Lys Glu Val Thr 
305                 310                 315                 320 


Ser Tyr Cys Ser Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Phe 
                325                 330                 335     


Val Lys Lys Trp Lys Ser Glu Trp Lys Asn Gln Lys Asn Lys Tyr Thr 
            340                 345                 350         


Glu Leu Tyr Glu Gln Asn Lys Asn Lys Thr Ser Ser Ser Ser Lys Asn 
        355                 360                 365             


Thr Ser Arg Tyr Asp Asp Tyr Val Lys Glu Phe Phe Lys Lys Leu Asn 
    370                 375                 380                 


Glu Ala Asn Tyr Lys Ser Leu Asp Asp Tyr Ile Lys Gly Asp Pro Tyr 
385                 390                 395                 400 


Ser Ala Glu Tyr Val Thr Lys Leu Ser Phe Ile Leu Asn Pro Ser Asp 
                405                 410                 415     


Ala Asn Asn Pro Ser Gly Glu Thr Ala Asn His Asn Asp Glu Val Cys 
            420                 425                 430         


Asn Cys Asn Glu Ser Glu Ile Ala Cys Val Glu Leu Ala Gln Thr Ser 
        435                 440                 445             


Gly Ser Ser Ser Asn Lys Thr Cys Ile Thr His Ser Ser Ile Lys Ala 
    450                 455                 460                 


Asn Lys Lys Lys Val Cys Lys Asp Val Lys Leu Gly Ile Asn Asn Asn 
465                 470                 475                 480 


Asp Lys Asp Leu Lys Ile Cys Val Ile Glu Asp Thr Ser Leu Ser Gly 
                485                 490                 495     


Val Glu Asn Cys Cys Cys Gln Asp Phe Leu Arg Met Leu Gln Glu Asn 
            500                 505                 510         


Cys Ser Asp Asn Lys Ser Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn 
        515                 520                 525             


Asn Asn Glu Asp Glu Cys Gln Lys Lys Leu Glu Lys Val Phe Ala Ser 
    530                 535                 540                 


Leu Thr Asn Gly Tyr Lys Cys Asp Lys Cys Lys Ser Glu Gln Ser Lys 
545                 550                 555                 560 


Lys Asn Asn Asn Ile Trp Ile Trp Arg Lys Ser Ser Gly Asp Glu Lys 
                565                 570                 575     


Gly Leu Gln Lys Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr 
            580                 585                 590         


Gln Ser Leu Tyr Leu Gly Asn Leu Pro Lys Leu Glu Asn Val Cys Glu 
        595                 600                 605             


Asp Val Thr Asp Ile Asn Phe Asp Thr Lys Glu Lys Phe Leu Ala Gly 
    610                 615                 620                 


Cys Leu Ile Ala Ala Phe His Glu Gly Lys Asn Leu Lys Lys Arg Tyr 
625                 630                 635                 640 


His Gln Asn Lys Asn Asp Glu Asn Lys Lys Lys Leu Cys Lys Ala Leu 
                645                 650                 655     


Lys Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile 
            660                 665                 670         


Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ile 
        675                 680                 685             


Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys Lys Asn Ile Ser Thr Glu 
    690                 695                 700                 


Gln Asp Thr Leu Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp 
705                 710                 715                 720 


Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala Met Lys His Gly Thr Thr 
                725                 730                 735     


Cys Ser Ser Gly Ser Gly Asp Asn Gly Asp Gly Ser Val Thr Gly Ser 
            740                 745                 750         


Ser Asp Ser Gly Ser Thr Thr Cys Cys Gly Asp Gly Ser Val Thr Gly 
        755                 760                 765             


Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln 
    770                 775                 780                 


Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg 
785                 790                 795                 800 


Gln Glu Lys Val Asn Ala Val Ile Asn Ser Cys Asn Ser Cys Lys Asn 
                805                 810                 815     


Thr Ser Ser Lys Thr Lys Leu Gly Asp Thr Cys Lys Thr Glu Cys Lys 
            820                 825                 830         


Asn Lys Cys Glu Ala Tyr Lys Asn Phe Ile Glu Asp Cys Lys Gly Gly 
        835                 840                 845             


Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Tyr Gln Ile Tyr 
    850                 855                 860                 


Met Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala 
865                 870                 875                 880 


Gly Thr Lys Ser Cys Gly Thr Ser Ser Gly Ala Thr Ser Gly Val Thr 
                885                 890                 895     


Thr Thr Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys 
            900                 905                 910         


His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile 
        915                 920                 925             


Val Leu Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr 
    930                 935                 940                 


Tyr Thr Thr Tyr Thr Thr Lys Asn Cys Asp Lys Asp Lys Lys Lys Ser 
945                 950                 955                 960 


Lys Ser Gln Ser Cys Asp Thr Leu Val Val Val Asn Val Pro Ser Pro 
                965                 970                 975     


Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Val Cys Glu Cys Arg Thr 
            980                 985                 990         


Pro Gly Gly Gly Gly Ser Gly Gly  Gly Gly Ser Asp Lys  Gly Gln Asn 
        995                 1000                 1005             


Asn Lys  Ser Leu Cys His Glu  Lys Gly Asn Asp Arg  Thr Trp Ser 
    1010                 1015                 1020             


Lys Lys  Tyr Ile Lys Lys Leu  Glu Asn Gly Arg Thr  Leu Glu Gly 
    1025                 1030                 1035             


Val Tyr  Val Pro Pro Arg Arg  Gln Gln Leu Cys Leu  Tyr Glu Leu 
    1040                 1045                 1050             


Phe Pro  Ile Ile Ile Lys Lys  Glu Asn Asp Ile Thr  Asn Ala Lys 
    1055                 1060                 1065             


Lys Glu  Leu Leu Glu Thr Leu  Gln Ile Val Ala Glu  Arg Glu Ala 
    1070                 1075                 1080             


Tyr Tyr  Leu Trp Lys Gln Tyr  Asn Pro Thr Gly Lys  Gly Ile Asp 
    1085                 1090                 1095             


Asp Ala  Asn Lys Lys Ala His  Lys Lys Ala Cys Cys  Ala Ile Arg 
    1100                 1105                 1110             


Gly Ser  Phe Tyr Asp Leu Glu  Asp Ile Ile Lys Gly  Asn Asp Leu 
    1115                 1120                 1125             


Val His  Asp Glu Tyr Thr Lys  Tyr Ile Asp Ser Lys  Leu Asn Lys 
    1130                 1135                 1140             


Ile Phe  Gly Ser Ser Asn Thr  Asn Asn Ile Asp Thr  Lys Arg Ala 
    1145                 1150                 1155             


Arg Thr  Asp Trp Trp Glu Asn  Glu Ile Ile Thr Asn  Gly Thr Asp 
    1160                 1165                 1170             


Ser Lys  Thr Ile Arg Gln Leu  Val Trp Asp Ala Met  Gln Ser Gly 
    1175                 1180                 1185             


Val Arg  Tyr Ala Val Glu Glu  Lys Asn Glu Asn Phe  Pro Pro Cys 
    1190                 1195                 1200             


Met Gly  Val Glu His Ile Gly  Ile Ala Lys Pro Gln  Phe Ile Arg 
    1205                 1210                 1215             


Trp Leu  Glu Glu Trp Thr Asn  Glu Phe Cys Glu Lys  Tyr Thr Lys 
    1220                 1225                 1230             


Tyr Phe  Glu Asp Met Lys Ser  Lys Cys Asp Pro Pro  Lys Ser Ala 
    1235                 1240                 1245             


Asp Asp  Cys Gly Asp Asn Ser  Asn Ile Glu Cys Lys  Arg Ala Cys 
    1250                 1255                 1260             


Ala Asn  Tyr Thr Asn Trp Leu  Asn Pro Lys Arg Ile  Glu Trp Asn 
    1265                 1270                 1275             


Gly Met  Ser Asn Tyr Tyr Asn  Lys Ile Tyr Arg Lys  Ser Asn Lys 
    1280                 1285                 1290             


Glu Ser  Glu Asp Gly Lys Asp  Tyr Ser Met Ile Met  Glu Pro Thr 
    1295                 1300                 1305             


Val Ile  Asp Tyr Leu Asn Lys  Arg Cys Asn Gly Glu  Ile Asn Gly 
    1310                 1315                 1320             


Asn Tyr  Ile Cys Cys Ser Cys  Lys Asn Ile Gly Glu  Asn Ser Thr 
    1325                 1330                 1335             


Ser Pro  Ala Gln Lys Thr Lys  Gly Ser Lys Lys Lys  Asp Glu Gln 
    1340                 1345                 1350             


Cys Glu  Asp Asn Lys Gly Pro  Leu Asp Leu Met Asn  Glu Val Leu 
    1355                 1360                 1365             


Asn Lys  Met Asp Glu Lys Tyr  Ser Glu His Lys Met  
    1370                 1375                 1380 


<210>  53
<211>  1357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  53

Met Asp Ser Thr Ser Thr Ile Gly Asp Lys Ile Glu Glu Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asn Glu Ser Asn Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Lys Val Gln Tyr Tyr Arg Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn 
    50                  55                  60                  


Asp Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Asn Asn Lys Asn Ile 
                85                  90                  95      


Phe Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Asn 
            100                 105                 110         


Leu Lys Phe Glu Arg Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Lys Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Lys Lys Ile Leu Glu 
            180                 185                 190         


Lys Asp Ser Thr Leu Lys Asn Asn Tyr Ser Asn Asp Asp Glu Asn Tyr 
        195                 200                 205             


Lys Lys Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys Val Trp 
    210                 215                 220                 


Glu Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg 
225                 230                 235                 240 


Arg Trp Thr Thr Ser Lys Glu Ser Asn Gly Glu Asn Lys Leu Glu Leu 
                245                 250                 255     


Cys Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp 
            260                 265                 270         


Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Leu 
        275                 280                 285             


Tyr Arg Glu Glu Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu 
    290                 295                 300                 


Glu Cys Thr Ser Glu Asp Asp Lys Ser Asn Glu Gly Thr Ser Tyr Cys 
305                 310                 315                 320 


Thr Asn Cys Lys Glu Lys His Thr Lys Tyr Cys Glu Cys Val Lys Lys 
                325                 330                 335     


Trp Lys Thr Glu Trp Glu Asn Gln Lys Asn Lys Tyr Asn Asp Leu Tyr 
            340                 345                 350         


Gln Gln Lys Lys Asn Glu Thr Ser Ser Ser Ser Lys Lys Lys Ser Arg 
        355                 360                 365             


Tyr Asp Asp Tyr Val Lys Asp Phe Phe Lys Lys Leu Lys Gly Asn Val 
    370                 375                 380                 


Tyr Ser Ser Ala Asn Ser Tyr Val Lys Asn Asp Pro Tyr Ser Lys Glu 
385                 390                 395                 400 


Tyr Val Thr Lys Leu Ser Phe Ile Leu Asn Pro Ser Asp Ala Asn Thr 
                405                 410                 415     


Ser Ser Gly Glu Thr Ala Asn His Asn Asp Glu Val Cys Asn Cys Asn 
            420                 425                 430         


Glu Ser Gly Ile Ala Cys Val Gly Gln Ala Gln Ile Ser Asp Arg Leu 
        435                 440                 445             


Ser Gln Lys Ala Cys Asn Thr His Ser Ser Ile Lys Thr Asn Lys Lys 
    450                 455                 460                 


Lys Glu Cys Lys His Val Lys Leu Gly Val Arg Glu Asn Asp Lys Val 
465                 470                 475                 480 


Leu Lys Ile Cys Val Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn 
                485                 490                 495     


Cys Cys Cys Gln Asp Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp 
            500                 505                 510         


Asn Ile Arg Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln 
        515                 520                 525             


Asp Glu Cys Glu Lys Asn Leu Asp Glu Ala Leu Ala Ser Leu Thr Asn 
    530                 535                 540                 


Cys Tyr Lys Cys Glu Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn 
545                 550                 555                 560 


Lys Asn Trp Ile Trp Lys Lys Tyr Ser Val Lys Glu Glu Gly Leu Gln 
                565                 570                 575     


Lys Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu 
            580                 585                 590         


Tyr Leu Gly Asn Leu Arg Lys Leu Glu Asn Val Cys Lys Asp Val Thr 
        595                 600                 605             


Asp Ile Asn Phe Asp Thr Lys Glu Lys Phe Leu Ala Gly Cys Leu Ile 
    610                 615                 620                 


Ala Ala Phe His Glu Gly Lys Asn Leu Lys Thr Thr Tyr Leu Glu Lys 
625                 630                 635                 640 


Lys Asn Asp Asp Asn Gly Lys Lys Leu Cys Lys Ala Leu Lys Tyr Ser 
                645                 650                 655     


Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn 
            660                 665                 670         


Asp Phe Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ala Phe Gly Lys 
        675                 680                 685             


Leu Phe Arg Lys Tyr Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr 
    690                 695                 700                 


Ser Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn 
705                 710                 715                 720 


Lys Lys Tyr Ile Trp Thr Ala Met Lys His Gly Thr Thr Cys Ser Ser 
                725                 730                 735     


Gly Ser Gly Asp Asn Gly Ser Ile Ser Cys Asp Asp Met Pro Thr Ile 
            740                 745                 750         


Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His 
        755                 760                 765             


Phe Cys Lys Gln Arg Gln Glu Lys Val Asn Ala Val Ile Thr Asn Cys 
    770                 775                 780                 


Lys Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr 
785                 790                 795                 800 


Glu Cys Glu Lys Lys Cys Lys Thr Lys Cys Lys Asp Glu Cys Asp Ala 
                805                 810                 815     


Tyr Lys Asn Phe Ile Glu Asn Cys Lys Gly Gly Asp Gly Thr Ala Gly 
            820                 825                 830         


Ser Pro Trp Ser Lys Arg Trp Asp Gln Ile Tyr Met Arg Tyr Ser Lys 
        835                 840                 845             


Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys 
    850                 855                 860                 


Gly Thr Ser Ala Ala Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser 
865                 870                 875                 880 


Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr 
                885                 890                 895     


Leu Ser Ile Val Leu Asp Glu Asn Ile Cys Gly Asp Asp Asn Ala Pro 
            900                 905                 910         


Trp Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys 
        915                 920                 925             


Ser Lys Ser Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser 
    930                 935                 940                 


Pro Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Val Cys Glu Cys Arg 
945                 950                 955                 960 


Thr Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Lys Lys 
                965                 970                 975     


Asn Asn Lys Ser Leu Cys His Glu Lys Gly Asn Asp Arg Thr Trp Ser 
            980                 985                 990         


Lys Lys Tyr Ile Lys Lys Leu Glu  Asn Gly Arg Thr Leu  Glu Gly Val 
        995                 1000                 1005             


Tyr Val  Pro Pro Arg Arg Gln  Gln Leu Cys Leu Tyr  Glu Leu Phe 
    1010                 1015                 1020             


Pro Ile  Ile Ile Lys Lys Glu  Lys Asp Met Glu Lys  Ala Lys Glu 
    1025                 1030                 1035             


Glu Leu  Leu Glu Thr Leu Gln  Ile Val Ala Glu Arg  Glu Ala Tyr 
    1040                 1045                 1050             


Tyr Leu  Trp Lys Gln Tyr Asn  Pro Thr Gly Lys Gly  Ile Asp Asp 
    1055                 1060                 1065             


Ala Asn  Lys Lys Ala Cys Cys  Ala Ile Arg Gly Ser  Phe Tyr Asp 
    1070                 1075                 1080             


Leu Glu  Asp Ile Ile Lys Gly  Asn Asp Leu Val His  Asp Glu Tyr 
    1085                 1090                 1095             


Thr Lys  Tyr Ile Asp Ser Lys  Leu Asn Lys Ile Phe  Gly Ser Ser 
    1100                 1105                 1110             


Asn Thr  Asn Asn Ile Asp Thr  Lys Arg Ala Arg Thr  Asp Trp Trp 
    1115                 1120                 1125             


Glu Asn  Lys Thr Ile Asp Val  Pro Lys Ile Asp Val  Ala Asn Gly 
    1130                 1135                 1140             


Thr Asp  Ser Lys Thr Ile Arg  Gln Leu Val Trp Asp  Ala Met Gln 
    1145                 1150                 1155             


Ser Gly  Val Arg Tyr Ala Val  Glu Lys Asn Glu Lys  Lys Lys Gln 
    1160                 1165                 1170             


Asn Glu  Asn Phe Pro Pro Cys  Met Arg Val Gln His  Ile Gly Ile 
    1175                 1180                 1185             


Ala Lys  Pro Gln Phe Ile Arg  Trp Leu Glu Glu Trp  Thr Asn Glu 
    1190                 1195                 1200             


Phe Cys  Glu Lys Tyr Thr Lys  Tyr Phe Glu Asp Met  Lys Ser Asn 
    1205                 1210                 1215             


Cys Asp  Pro Pro Lys Gly Ala  Asp Asp Cys Gly Asp  Asn Ser Asn 
    1220                 1225                 1230             


Ile Glu  Cys Lys Lys Ala Cys  Ala Asn Tyr Thr Asn  Trp Leu Asn 
    1235                 1240                 1245             


Pro Lys  Arg Ile Glu Trp Asn  Gly Met Ser Asn Tyr  Tyr Asn Lys 
    1250                 1255                 1260             


Ile Tyr  Arg Lys Ser Asn Lys  Glu Ser Glu Asp Gly  Lys Asp Tyr 
    1265                 1270                 1275             


Ser Met  Ile Met Glu Pro Thr  Val Ile Asp Tyr Leu  Asn Lys Arg 
    1280                 1285                 1290             


Cys His  Gly Glu Ile Asn Gly  Asn Tyr Ile Cys Cys  Ser Cys Lys 
    1295                 1300                 1305             


Asn Ile  Gly Glu Asn Ser Thr  Ser Pro Ala Gln Lys  Thr Lys Gly 
    1310                 1315                 1320             


Ser Lys  Lys Lys Gly Glu Gln  Cys Glu Asp Asn Lys  Gly Pro Leu 
    1325                 1330                 1335             


Asp Leu  Met Asn Glu Val Leu  Asn Lys Met Asp Glu  Lys Tyr Ser 
    1340                 1345                 1350             


Ala His  Lys Met 
    1355         


<210>  54
<211>  1387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  54

Met Asp Ser Lys Thr Thr Ile Ala Glu Lys Ile Glu Ala Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asn Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn 
    50                  55                  60                  


Asp Pro Cys Asp Ser Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Lys Pro Glu Asn Val 
                85                  90                  95      


Phe Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Asn 
            100                 105                 110         


Leu Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Ile Leu Tyr His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Gln Asn Leu Arg Arg Met Phe Ala Lys Ile Arg Glu 
            180                 185                 190         


Asn Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Thr 
        195                 200                 205             


Lys Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly 
225                 230                 235                 240 


Trp Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Gln Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr 
        275                 280                 285             


Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Glu Tyr Asp Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser 
305                 310                 315                 320 


Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp 
                325                 330                 335     


Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Asn Asp Leu Tyr Gln 
            340                 345                 350         


Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asn 
        355                 360                 365             


Tyr Val Lys Glu Phe Phe Lys Asn Phe Lys Gly Asp Asn Tyr Lys Ser 
    370                 375                 380                 


Leu Glu Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Val Thr 
385                 390                 395                 400 


Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Thr Ser Ser Glu 
                405                 410                 415     


Lys Ile Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Glu 
            420                 425                 430         


Ile Ala Ser Val Gly Gln Ala Ser Ile Ser Asp Pro Ser Ser Asn Lys 
        435                 440                 445             


Thr Cys Asn Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys 
    450                 455                 460                 


Lys Asp Val Lys Leu Gly Val Arg Glu Lys Asp Lys Asp Leu Lys Ile 
465                 470                 475                 480 


Cys Val Ile Glu Asp Asp Ser Leu Arg Gly Val Asp Asn Cys Cys Cys 
                485                 490                 495     


Gln Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Asp Glu Cys 
        515                 520                 525             


Gln Lys Lys Leu Glu Asn Val Phe Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Cys Asp Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Asn Lys Trp 
545                 550                 555                 560 


Ile Trp Arg Lys Phe Pro Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr 
                565                 570                 575     


Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Leu Leu Tyr Leu Val 
            580                 585                 590         


Cys Leu His Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg 
        595                 600                 605             


Thr Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu 
    610                 615                 620                 


Gly Lys Asn Leu Lys Thr Thr Tyr Pro Gln Lys Lys Asn Asp Asp Asn 
625                 630                 635                 640 


Gly Lys Lys Leu Cys Lys Asp Leu Lys Tyr Ser Phe Ala Asp Tyr Gly 
                645                 650                 655     


Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Asp Phe Thr Lys Asp 
            660                 665                 670         


Leu Glu Leu Asn Leu Gln Gln Ile Phe Gly Lys Leu Phe Arg Lys Tyr 
        675                 680                 685             


Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp 
705                 710                 715                 720 


Thr Ala Met Lys His Gly Ala Gly Met Asn Ser Thr Met Cys Asn Ala 
                725                 730                 735     


Asp Gly Ser Val Thr Gly Ser Ser Asp Ser Gly Ser Thr Thr Cys Ser 
            740                 745                 750         


Gly Asp Asn Gly Ser Ile Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu 
        755                 760                 765             


Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe Cys 
    770                 775                 780                 


Glu Gln Arg Gln Ala Lys Val Asn Ala Val Ile Thr Asn Cys Lys Ser 
785                 790                 795                 800 


Cys Lys Glu Ser Gly Gly Thr Cys Asn Ser Asp Cys Lys Thr Glu Cys 
                805                 810                 815     


Lys Asn Lys Cys Lys Val Ala Cys Asp Ala Tyr Lys Thr Phe Ile Glu 
            820                 825                 830         


Asp Cys Lys Gly Gly Gly Thr Gly Thr Ala Gly Ser Ser Trp Val Lys 
        835                 840                 845             


Arg Trp Tyr Gln Ile Tyr Met Arg Tyr Ser Lys Tyr Ile Glu Asp Ala 
    850                 855                 860                 


Lys Arg Asn Arg Lys Ala Gly Thr Lys Ser Cys Gly Thr Ser Ser Gly 
865                 870                 875                 880 


Ala Asn Ser Gly Val Thr Thr Ala Glu Asn Lys Cys Val Gln Ser Asp 
                885                 890                 895     


Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro 
            900                 905                 910         


Ser Ser Tyr Leu Ser Asn Val Leu Asp Glu Asn Asn Cys Gly Glu Asp 
        915                 920                 925             


Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Tyr Thr Thr Tyr 
    930                 935                 940                 


Thr Thr Thr Lys Asn Cys Asp Lys Asp Lys Lys Lys Ser Lys Ser Gln 
945                 950                 955                 960 


Ser Cys Asp Thr Leu Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
                965                 970                 975     


Thr Pro His Gly Tyr Lys Tyr Ala Cys Glu Cys Lys Ile Pro Gly Gly 
            980                 985                 990         


Gly Gly Ser Gly Gly Gly Gly Ser  Ala Glu Lys Lys Asn  Asn Lys Ser 
        995                 1000                 1005             


Leu Cys  His Glu Lys Gly Asn  Asp Arg Thr Trp Ser  Lys Lys Tyr 
    1010                 1015                 1020             


Ile Lys  Lys Leu Glu Asn Gly  Arg Thr Leu Glu Gly  Val Tyr Val 
    1025                 1030                 1035             


Pro Pro  Arg Arg Gln Gln Leu  Cys Leu Tyr Glu Leu  Phe Pro Ile 
    1040                 1045                 1050             


Ile Ile  Lys Lys Glu Lys Asp  Met Glu Lys Ala Lys  Lys Glu Leu 
    1055                 1060                 1065             


Leu Glu  Thr Leu Lys Ile Val  Ala Glu Arg Glu Ala  Tyr Tyr Leu 
    1070                 1075                 1080             


Trp Lys  Gln Tyr Asn Pro Thr  Gly Lys Gly Ile Asp  Asp Ala Asn 
    1085                 1090                 1095             


Lys Lys  Ala Cys Cys Ala Ile  Arg Gly Ser Phe Tyr  Asp Leu Glu 
    1100                 1105                 1110             


Asp Ile  Ile Lys Gly Asn Asp  Leu Val His Asp Glu  Tyr Thr Lys 
    1115                 1120                 1125             


Tyr Ile  Asp Ser Lys Leu Asn  Glu Ile Phe Gly Ser  Ser Asn Lys 
    1130                 1135                 1140             


Asn Asp  Ile Asp Thr Lys Arg  Ala Arg Thr Asp Trp  Trp Glu Asn 
    1145                 1150                 1155             


Glu Thr  Ile Asp Val Pro Asn  Ile Thr Gly Ala Asn  Lys Ser Asp 
    1160                 1165                 1170             


Ser Lys  Thr Ile Arg Gln Leu  Val Trp Asp Ala Met  Gln Ser Gly 
    1175                 1180                 1185             


Val Arg  Lys Ala Ile Tyr Glu  Glu Lys Glu Lys Lys  Lys Gln Asn 
    1190                 1195                 1200             


Glu Asn  Phe Pro Pro Cys Met  Arg Val Glu His Ile  Gly Ile Ala 
    1205                 1210                 1215             


Lys Pro  Gln Phe Ile Arg Trp  Leu Glu Glu Trp Thr  Asn Glu Phe 
    1220                 1225                 1230             


Cys Glu  Glu Tyr Thr Lys Tyr  Phe Glu Asp Met Lys  Ser Lys Cys 
    1235                 1240                 1245             


Asp Pro  Pro Lys Arg Ala Asp  Asp Cys Gly Asp Asn  Thr Asn Ile 
    1250                 1255                 1260             


Glu Cys  Lys Lys Ala Cys Ala  Asn Tyr Thr Asn Trp  Leu Asn Pro 
    1265                 1270                 1275             


Lys Arg  Ile Glu Trp Asn Gly  Met Ser Asn Tyr Tyr  Asn Lys Ile 
    1280                 1285                 1290             


Tyr Arg  Lys Ser Asn Lys Glu  Ser Glu Asp Gly Lys  Asp Tyr Ser 
    1295                 1300                 1305             


Met Ile  Met Glu Pro Thr Val  Ile Asp Tyr Leu Asn  Lys Arg Cys 
    1310                 1315                 1320             


His Gly  Glu Ile Asn Gly Asn  Tyr Ile Cys Cys Ser  Cys Lys Asn 
    1325                 1330                 1335             


Ile Gly  Glu Asn Tyr Asn Pro  Ser Pro Ala Gln Lys  Thr Lys Gly 
    1340                 1345                 1350             


Ser Lys  Lys Lys Asp Glu Gln  Cys Glu Asp Asn Lys  Gly Pro Leu 
    1355                 1360                 1365             


Asp Leu  Met Asn Glu Val Leu  Asn Lys Met Asp Glu  Lys Tyr Ser 
    1370                 1375                 1380             


Ala His  Lys Met 
    1385         


<210>  55
<211>  3093
<212>  PRT
<213>  Plasmodium falciparum

<400>  55

Met Asp Lys Ser Ser Ile Gly Asp Lys Ile Glu Glu Tyr Leu Lys Glu 
1               5                   10                  15      


Lys Ser Asp Asp Ser Lys Ile Asp Glu Leu Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Lys Asn 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr Glu 
    50                  55                  60                  


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Gln Gln Asn Leu Tyr Lys Ala Ser Glu Asn Asn Lys Asn Val Phe 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Asn Leu 
            100                 105                 110         


Asn Val Glu Arg Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Ile Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Ile Ala Asp Ile Ile Arg Gly Arg Asp Gly Asn Lys Cys Glu Thr Lys 
                165                 170                 175     


Ser Thr Asn Asn Val Glu Glu Leu Ile Lys Lys Phe Phe Glu Lys Asn 
            180                 185                 190         


Tyr Arg Glu Asn Lys Glu Tyr Lys Arg Lys Tyr Pro Asn Asp Asp Pro 
        195                 200                 205             


Lys Tyr Thr Lys Leu Arg Glu Asp Trp Trp Thr Lys Asn Arg Gln Lys 
    210                 215                 220                 


Val Trp Glu Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile 
225                 230                 235                 240 


Lys Arg Gly Trp Thr Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys Leu 
                245                 250                 255     


Glu Leu Cys Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys 
            260                 265                 270         


Leu Asp Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu 
        275                 280                 285             


Asp Leu Tyr Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His 
    290                 295                 300                 


Arg Glu Glu Cys Thr Ser Glu Asp His Lys Ser Lys Glu Gly Ala Ser 
305                 310                 315                 320 


Tyr Cys Asn Met Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val 
                325                 330                 335     


Lys Lys Trp Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Lys Asp 
            340                 345                 350         


Leu Tyr Gln Gln Glu Asn Glu Thr Ser Ser Ser Ser Lys Lys Lys Ser 
        355                 360                 365             


Arg Tyr Asp Asp Tyr Val Lys Glu Phe Phe Lys Lys Leu Asn Glu Ala 
    370                 375                 380                 


Asn Tyr Ser Ser Leu Glu Asn Tyr Ile Lys Asp Asp Pro Tyr Ser Lys 
385                 390                 395                 400 


Glu Tyr Val Thr Lys Leu Ser Phe Ile Pro Asn Ser Ser Asp Ala Asn 
                405                 410                 415     


Thr Ser Ser Glu Lys Ile Gln Lys Asn Asn Asp Glu Val Cys Asn Pro 
            420                 425                 430         


Asn Glu Ser Gly Ile Ser Ser Val Glu Gln Ala Gln Thr Ser Gly Pro 
        435                 440                 445             


Ser Ser Asn Lys Thr Cys Ile Thr His Ser Ser Ile Lys Ala Asn Lys 
    450                 455                 460                 


Lys Lys Glu Cys Lys Asp Val Lys Leu Gly Val Arg Glu Asn Asp Lys 
465                 470                 475                 480 


Asp Leu Lys Ile Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp 
                485                 490                 495     


Asn Cys Cys Cys Gln Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser 
            500                 505                 510         


Asp Asn Lys Arg Gly Ser Ser Ser Asn Asp Ser Cys Asp Asn Lys Asn 
        515                 520                 525             


Gln Asp Glu Cys Gln Lys Lys Leu Asp Glu Ala Leu Glu Ser Leu His 
    530                 535                 540                 


Asn Gly Tyr Lys Asn Gln Lys Cys Lys Ser Gly Thr Ser Thr Val Asn 
545                 550                 555                 560 


Lys Lys Trp Ile Trp Lys Lys Ser Ser Gly Asn Lys Glu Gly Leu Gln 
                565                 570                 575     


Lys Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu 
            580                 585                 590         


Tyr Leu Gly Asn Leu Pro Lys Leu Glu Asn Val Ser Lys Gly Val Thr 
        595                 600                 605             


Asp Ile Ile Tyr Asp Thr Lys Glu Lys Phe Leu Ala Gly Cys Leu Ile 
    610                 615                 620                 


Val Ser Phe His Glu Gly Lys Asn Leu Lys Thr Ser His Glu Lys Lys 
625                 630                 635                 640 


Asn Asp Asp Asn Gly Lys Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe 
                645                 650                 655     


Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu 
            660                 665                 670         


Tyr Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ala Phe Gly Lys Leu 
        675                 680                 685             


Phe Arg Lys Tyr Ile Lys Lys Asn Ile Ser Ala Glu Gln Asp Thr Ser 
    690                 695                 700                 


Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys 
705                 710                 715                 720 


Lys Tyr Ile Trp Ile Ala Met Lys His Gly Ala Gly Met Asn Gly Thr 
                725                 730                 735     


Thr Cys Cys Gly Asp Gly Ser Ser Gly Glu Asn Gln Thr Asn Ser Cys 
            740                 745                 750         


Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu 
        755                 760                 765             


Gln Glu Trp Val Glu His Phe Cys Glu Gln Arg Gln Ala Lys Val Lys 
    770                 775                 780                 


Asp Val Ile Thr Asn Cys Lys Ser Cys Lys Asn Thr Ser Gly Glu Arg 
785                 790                 795                 800 


Lys Ile Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Lys Cys Lys Asn 
                805                 810                 815     


Lys Cys Glu Ala Tyr Lys Thr Phe Ile Glu His Cys Lys Gly Gly Asp 
            820                 825                 830         


Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln Ile Tyr Lys 
        835                 840                 845             


Arg Tyr Ser Lys His Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly 
    850                 855                 860                 


Thr Lys Ser Cys Gly Thr Ser Thr Ala Glu Asn Lys Cys Val Gln Ser 
865                 870                 875                 880 


Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr 
                885                 890                 895     


Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp Glu Asn Asn Cys Gly Glu 
            900                 905                 910         


Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Thr Lys Asn Cys Asp Ile 
        915                 920                 925             


Gln Lys Asp Lys Ser Lys Ser Gln Ser Ser Asp Thr Leu Val Val Val 
    930                 935                 940                 


Asn Val Pro Ser Pro Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala 
945                 950                 955                 960 


Cys Gln Cys Lys Ile Pro Thr Thr Glu Glu Thr Cys Asp Asp Arg Lys 
                965                 970                 975     


Glu Tyr Met Asn Gln Trp Ser Cys Gly Ser Ala Arg Thr Met Lys Arg 
            980                 985                 990         


Gly Tyr Lys Asn Asp Asn Tyr Glu  Leu Cys Lys Tyr Asn  Gly Val Asp 
        995                 1000                 1005             


Val Lys  Pro Thr Thr Val Arg  Ser Ser Ser Thr Lys  Leu Asp Gly 
    1010                 1015                 1020             


Asn Asp  Val Met Phe Phe Asn  Leu Phe Glu Gln Trp  Asn Lys Glu 
    1025                 1030                 1035             


Ile Gln  Tyr Gln Ile Glu Gln  Tyr Met Thr Asn Ala  Asn Ile Ser 
    1040                 1045                 1050             


Cys Asn  Asn Glu Met Lys Val  Leu Ser Ser Ser Ser  Glu Glu Ser 
    1055                 1060                 1065             


Gln Asn  Gln Asn Gly Ser Asp  His His Asp Gly Arg  Asn Asn Asn 
    1070                 1075                 1080             


Thr Asp  Gln Ser Thr Asn Cys  Lys Glu Lys Cys Glu  Cys Tyr Lys 
    1085                 1090                 1095             


Leu Trp  Ile Glu Lys Ile Lys  Lys Gln Trp Gly Lys  Gln Lys Asn 
    1100                 1105                 1110             


Asn Tyr  Asn Lys Phe Arg Ser  Lys Gln Ile Tyr Asp  Ala Asn Lys 
    1115                 1120                 1125             


Gly Pro  Gln Asn Lys Lys Val  Val Ser Leu Ser His  Phe Leu Phe 
    1130                 1135                 1140             


Phe Ser  Cys Trp Glu Glu Tyr  Ile Gln Lys Gln Phe  Asn Gly Asp 
    1145                 1150                 1155             


Trp Ser  Lys Ile Lys Asn Ile  Gly Ser Asp Thr Phe  Glu Phe Leu 
    1160                 1165                 1170             


Ile Lys  Lys Cys Gly Asn Asn  Ser Gly Asp Gly Glu  Thr Ile Phe 
    1175                 1180                 1185             


Asn Lys  Lys Leu Lys Asn Ala  Glu Lys Lys Cys Lys  Glu Asn Glu 
    1190                 1195                 1200             


Ser Thr  Asp Thr Lys Met Lys  Ser Ser Glu Thr Ser  Cys Asp Leu 
    1205                 1210                 1215             


Asn Ala  Thr Asn Tyr Ile Arg  Gly Cys Gln Ser Lys  Thr Tyr Asp 
    1220                 1225                 1230             


Gly Lys  Ile Phe Pro Gly Lys  Gly Gly Glu Lys Gln  Trp Ile Cys 
    1235                 1240                 1245             


Lys Asp  Thr Ile Ile His Gly  Asp Thr Asn Gly Ala  Cys Ile Pro 
    1250                 1255                 1260             


Pro Arg  Thr Gln Asn Leu Cys  Val Gly Asn Leu Trp  Asp Lys Ser 
    1265                 1270                 1275             


Tyr Gly  Gly Arg Ser Asn Ile  Lys Asn Asp Thr Lys  Glu Ser Leu 
    1280                 1285                 1290             


Lys Asn  Lys Leu Lys Asn Ala  Ile Gln Lys Glu Thr  Glu Leu Leu 
    1295                 1300                 1305             


Tyr Glu  Tyr His Asp Lys Gly  Thr Ala Ile Ile Ser  Arg Asn Pro 
    1310                 1315                 1320             


Met Lys  Glu Gly Gly Glu Asp  Gly Lys Gly Lys Gln  Lys Glu Gly 
    1325                 1330                 1335             


Gly Glu  Glu Ala Asn Asn Asn  Ser Asn Gly Leu Pro  Lys Gly Phe 
    1340                 1345                 1350             


Cys His  Ala Val Gln Arg Ser  Phe Ile Asp Tyr Lys  Asn Met Ile 
    1355                 1360                 1365             


Leu Gly  Thr Ser Val Asn Thr  Tyr Glu Tyr Ile Gly  Lys Leu Gln 
    1370                 1375                 1380             


Glu Asp  Ile Lys Lys Ile Ile  Glu Lys Gly Thr Pro  Gln Gln Lys 
    1385                 1390                 1395             


Asp Lys  Ile Gly Gly Val Gly  Ser Ser Thr Glu Asn  Val Asn Ala 
    1400                 1405                 1410             


Trp Trp  Lys Gly Ile Glu Gly  Glu Met Trp Asp Ala  Val Arg Cys 
    1415                 1420                 1425             


Ala Ile  Thr Lys Ile Lys Lys  Gln Lys Lys Asn Gly  Thr Phe Asn 
    1430                 1435                 1440             


Gly Asp  Glu Cys Gly Val Ser  Pro Pro Thr Gly Asn  Asp Glu Asp 
    1445                 1450                 1455             


Gln Phe  Val Ser Trp Phe Lys  Glu Trp Gly Glu Gln  Phe Cys Ile 
    1460                 1465                 1470             


Glu Arg  Leu Arg Tyr Glu Gln  Asn Ile Arg Glu Ala  Cys Thr Ile 
    1475                 1480                 1485             


Asn Gly  Lys Asn Glu Lys Lys  Cys Ile Asn Ser Lys  Ser Gly Gln 
    1490                 1495                 1500             


Gly Asp  Lys Ile Gln Gly Ala  Cys Lys Arg Lys Cys  Glu Lys Tyr 
    1505                 1510                 1515             


Lys Lys  Tyr Ile Ser Glu Lys  Lys Gln Glu Trp Asp  Lys Gln Lys 
    1520                 1525                 1530             


Thr Lys  Tyr Glu Asn Lys Tyr  Val Gly Lys Ser Ala  Ser Asp Leu 
    1535                 1540                 1545             


Leu Lys  Glu Asn Tyr Pro Glu  Cys Ile Ser Ala Asn  Phe Asp Phe 
    1550                 1555                 1560             


Ile Phe  Asn Asp Asn Ile Glu  Tyr Lys Thr Tyr Tyr  Pro Tyr Gly 
    1565                 1570                 1575             


Asp Tyr  Ser Ser Ile Cys Ser  Cys Glu Gln Val Lys  Tyr Tyr Lys 
    1580                 1585                 1590             


Tyr Asn  Asn Ala Glu Lys Lys  Asn Asn Lys Ser Leu  Cys His Glu 
    1595                 1600                 1605             


Lys Gly  Asn Asp Arg Thr Trp  Ser Lys Lys Tyr Ile  Lys Lys Leu 
    1610                 1615                 1620             


Glu Asn  Gly Arg Thr Leu Glu  Gly Val Tyr Val Pro  Pro Arg Arg 
    1625                 1630                 1635             


Gln Gln  Leu Cys Leu Tyr Glu  Leu Phe Pro Ile Ile  Ile Lys Asn 
    1640                 1645                 1650             


Lys Asn  Asp Ile Thr Asn Ala  Lys Glu Glu Leu Leu  Glu Thr Leu 
    1655                 1660                 1665             


Gln Ile  Val Ala Glu Arg Glu  Ala Tyr Tyr Leu Trp  Lys Gln Tyr 
    1670                 1675                 1680             


Asn Pro  Thr Gly Lys Gly Ile  Asp Asp Ala Asn Lys  Lys Ala Cys 
    1685                 1690                 1695             


Cys Ala  Ile Arg Gly Ser Phe  Tyr Asp Leu Glu Asp  Ile Ile Lys 
    1700                 1705                 1710             


Gly Asn  Asp Leu Val His Asp  Glu Tyr Thr Lys Tyr  Ile Asp Ser 
    1715                 1720                 1725             


Lys Leu  Asn Glu Ile Phe Gly  Ser Ser Asn Lys Asn  Asp Ile Glu 
    1730                 1735                 1740             


Thr Lys  Arg Ala Arg Thr Asp  Trp Trp Glu Asn Glu  Thr Ile Thr 
    1745                 1750                 1755             


Asn Gly  Thr Asp Arg Lys Thr  Ile Arg Gln Leu Val  Trp Asp Ala 
    1760                 1765                 1770             


Met Gln  Ser Gly Val Arg Lys  Ala Ile Asp Glu Glu  Lys Glu Lys 
    1775                 1780                 1785             


Lys Lys  Pro Asn Glu Asn Phe  Pro Pro Cys Met Gly  Val Glu His 
    1790                 1795                 1800             


Ile Gly  Ile Ala Lys Pro Gln  Phe Ile Arg Trp Leu  Glu Glu Trp 
    1805                 1810                 1815             


Thr Asn  Glu Phe Cys Glu Glu  Tyr Thr Lys Tyr Phe  Glu Asp Met 
    1820                 1825                 1830             


Lys Ser  Asn Cys Asn Arg Arg  Lys Gly Ala Asp Asp  Cys Gly Asp 
    1835                 1840                 1845             


Asn Thr  Asn Ile Glu Cys Lys  Lys Ala Cys Ala Asn  Tyr Thr Asn 
    1850                 1855                 1860             


Trp Leu  Asn Pro Lys Arg Ile  Glu Trp Asn Gly Met  Ser Asn Tyr 
    1865                 1870                 1875             


Tyr Asn  Lys Ile Tyr Arg Lys  Ser Asn Lys Glu Ser  Glu Asp Gly 
    1880                 1885                 1890             


Lys Asp  Tyr Ser Met Ile Met  Glu Pro Thr Val Ile  Asp Tyr Leu 
    1895                 1900                 1905             


Asn Lys  Arg Cys Asn Gly Glu  Ile Asn Gly Asn Tyr  Ile Cys Cys 
    1910                 1915                 1920             


Ser Cys  Lys Asn Ile Gly Ala  Tyr Asn Thr Thr Ser  Gly Thr Val 
    1925                 1930                 1935             


Asn Lys  Lys Leu Gln Lys Lys  Glu Thr Glu Cys Glu  Asp Asn Lys 
    1940                 1945                 1950             


Gly Pro  Leu Asp Leu Met Asn  Glu Val Leu Asn Lys  Met Asp Glu 
    1955                 1960                 1965             


Lys Tyr  Ser Lys Leu Asn Leu  Lys Cys Thr Glu Val  Tyr Leu Glu 
    1970                 1975                 1980             


His Val  Glu Glu Gln Leu Asn  Glu Ile Asp Asn Ala  Ile Lys Asp 
    1985                 1990                 1995             


Tyr Gln  Leu Tyr Pro Leu Asp  Arg Cys Phe Asp Asp  Gln Thr Lys 
    2000                 2005                 2010             


Met Lys  Ile Cys Asp Leu Ile  Gly Asp Ala Ile Gly  Cys Lys Asp 
    2015                 2020                 2025             


Lys Thr  Lys Leu Asp Glu Leu  Asp Glu Trp Asn Asp  Met Asp Met 
    2030                 2035                 2040             


Arg Asp  Pro Tyr Asn Lys Tyr  Lys Gly Val Leu Ile  Pro Pro Arg 
    2045                 2050                 2055             


Arg Arg  Gln Leu Cys Phe Ser  Arg Ile Val Arg Gly  Pro Ala Asn 
    2060                 2065                 2070             


Leu Arg  Asn Leu Asn Glu Phe  Lys Glu Glu Ile Leu  Lys Gly Ala 
    2075                 2080                 2085             


Gln Ser  Glu Gly Lys Phe Leu  Gly Asn Tyr Tyr Asn  Glu Asp Lys 
    2090                 2095                 2100             


Asp Lys  Glu Lys Lys Glu Asp  Arg Lys Glu Lys Ala  Leu Glu Ala 
    2105                 2110                 2115             


Met Lys  Asn Ser Phe Tyr Asp  Tyr Glu Asp Ile Ile  Lys Gly Ser 
    2120                 2125                 2130             


Asp Met  Leu Ala Asn Ile Gln  Phe Lys Asp Ile Lys  Arg Lys Leu 
    2135                 2140                 2145             


Asp Lys  Leu Leu Thr Lys Lys  Thr Asn Asn Asn Ile  Arg Asn Ala 
    2150                 2155                 2160             


Glu Asp  Trp Trp Lys Thr Asn  Lys Lys Ser Ile Trp  Asn Ala Met 
    2165                 2170                 2175             


Leu Cys  Gly Tyr Lys Lys Ser  Gly Asn Lys Ile Ile  Asp Pro Ser 
    2180                 2185                 2190             


Trp Cys  Lys Ile Pro Thr Thr  Glu Lys Thr Pro Gln  Phe Leu Arg 
    2195                 2200                 2205             


Trp Ile  Lys Glu Trp Gly Thr  Asn Val Cys Ile Gln  Lys Glu Lys 
    2210                 2215                 2220             


Tyr Lys  Gln Asn Val Lys Leu  Glu Cys Ser Asn Val  Thr Asn Ile 
    2225                 2230                 2235             


Asp Leu  Ser Leu Gln Ala Ser  Glu Ser Thr Lys Cys  Ile Pro Glu 
    2240                 2245                 2250             


Ile Arg  Lys Tyr Gln Glu Trp  Ser Arg Lys Arg Ser  Ile Gln Trp 
    2255                 2260                 2265             


Glu Ala  Ile Ser Glu Arg Tyr  Arg Lys Tyr Lys Arg  Met Asp Glu 
    2270                 2275                 2280             


Phe Lys  Asn Val Phe Asn Asn  Ala Asn Glu Pro Asn  Ala Asn Glu 
    2285                 2290                 2295             


Tyr Leu  Lys Glu Tyr Cys Ser  Lys Cys Pro Cys Gly  Phe Asn Asp 
    2300                 2305                 2310             


Met Glu  Glu Ile Thr Asn Asp  Thr Glu Asn Lys Gln  Asp Ile Phe 
    2315                 2320                 2325             


Lys Gln  Ile Ile Glu Lys Val  Lys Ile Pro Ala Glu  Leu Glu Asp 
    2330                 2335                 2340             


Val Ile  Tyr Arg Leu Lys His  His Glu Tyr Asn Ser  Asn Asp Tyr 
    2345                 2350                 2355             


Ile Cys  Asn Lys Tyr Lys Asn  Ile Asn Val Asn Met  Lys Lys Asn 
    2360                 2365                 2370             


Asn Gly  Asn Phe Val Thr Asp  Asn Phe Val Lys Lys  Ser Trp Glu 
    2375                 2380                 2385             


Ile Ser  Asn Gly Val Leu Ile  Pro Pro Arg Arg Lys  Asn Leu Phe 
    2390                 2395                 2400             


Leu Asn  Ile Lys Asp Thr Gln  Ile Cys Gln Tyr Lys  Arg Asp Pro 
    2405                 2410                 2415             


Lys Leu  Phe Asn Asp Phe Ile  Tyr Ser Ser Ala Phe  Thr Glu Val 
    2420                 2425                 2430             


Glu Met  Leu Lys Lys Leu Tyr  Pro Lys Asp Arg Ala  Lys Val Val 
    2435                 2440                 2445             


His Ala  Met Lys Tyr Ser Phe  Thr Asp Ile Gly Ser  Ile Ile Lys 
    2450                 2455                 2460             


Gly Asp  Asp Met Met Glu Lys  Asn Ser Ser Asp Lys  Ile Gly Lys 
    2465                 2470                 2475             


Ile Leu  Gly Asp Thr Asp Gly  Gln Asn Glu Lys Arg  Lys Lys Trp 
    2480                 2485                 2490             


Trp Asp  Ser Asn Lys Tyr His  Ile Trp Glu Ser Met  Leu Cys Gly 
    2495                 2500                 2505             


Tyr Lys  His Ala Tyr Gly Asn  Ile Ser His Asp Asp  Lys Lys Lys 
    2510                 2515                 2520             


Leu Asp  Ile Pro Asn Asn Asp  Asn Glu His Gln Phe  Leu Arg Trp 
    2525                 2530                 2535             


Phe Thr  Glu Trp Ala Glu Asp  Phe Cys Asn Asn Arg  Tyr Lys Glu 
    2540                 2545                 2550             


Leu Glu  Lys Leu Lys Met Ser  Cys Pro His Asn Val  Cys Phe Leu 
    2555                 2560                 2565             


Asp Glu  Gly Thr Glu Lys Lys  Cys Met Glu Ala Cys  Glu Lys Tyr 
    2570                 2575                 2580             


Gln Asn  Tyr Val Leu Ser Lys  Lys Thr Glu Tyr Glu  Ile Gln Lys 
    2585                 2590                 2595             


Asn Lys  Tyr Tyr Ala Glu Phe  Lys Asn Lys Asn Gly  Asn Ala Lys 
    2600                 2605                 2610             


Asp Ala  Pro Glu Tyr Phe Lys  Asp Asn Cys Lys Asn  Asn Cys Glu 
    2615                 2620                 2625             


Cys Phe  Ser Lys His Ile Asp  Ile Lys Lys Asn Trp  Lys Glu Pro 
    2630                 2635                 2640             


Tyr Ala  Thr Leu Glu Asp Thr  Phe Lys Ser Lys Cys  Asp Cys Pro 
    2645                 2650                 2655             


Lys Pro  Val Pro Pro Pro Pro  Glu Lys Pro Gln Pro  Pro Pro Leu 
    2660                 2665                 2670             


Thr Pro  Ser Asp Glu Pro Phe  Asp Pro Thr Ile Leu  Gln Thr Thr 
    2675                 2680                 2685             


Ile Pro  Phe Gly Ile Ala Leu  Ala Leu Gly Ser Ile  Ala Phe Leu 
    2690                 2695                 2700             


Phe Met  Lys Lys Lys Pro Lys  Thr Pro Val Asp Leu  Leu Arg Val 
    2705                 2710                 2715             


Leu Asp  Ile His Lys Gly Asp  Tyr Gly Ile Pro Thr  Leu Lys Ser 
    2720                 2725                 2730             


Ser Asn  Arg Tyr Ile Pro Tyr  Val Ser Asp Thr Tyr  Lys Gly Lys 
    2735                 2740                 2745             


Thr Tyr  Ile Tyr Met Glu Gly  Asp Thr Ser Gly Asp  Asp Asp Lys 
    2750                 2755                 2760             


Tyr Ile  Trp Asp Leu Ser Ser  Ser Asp Ile Thr Ser  Ser Glu Ser 
    2765                 2770                 2775             


Glu Tyr  Glu Glu Leu Asp Ile  Asn Asp Ile Tyr Val  Pro Ser Leu 
    2780                 2785                 2790             


Pro Lys  Tyr Lys Thr Leu Ile  Glu Val Val Leu Glu  Pro Ser Lys 
    2795                 2800                 2805             


Arg Asp  Thr Phe Asn Thr Pro  Ser Gly Asp Thr Phe  Thr Asn Lys 
    2810                 2815                 2820             


Leu Thr  Asp Asp Glu Trp Asn  Gln Leu Lys Gln Asp  Phe Ile Glu 
    2825                 2830                 2835             


Gln Tyr  Leu Gln Asn Ile Gln  Lys Asp Phe Ile Leu  His Asp Ser 
    2840                 2845                 2850             


Val Asn  Glu Lys Pro Phe Ile  Thr Gln Ile Gln Asp  Arg Phe Leu 
    2855                 2860                 2865             


Gly Ser  Gly His Gln Val Thr  Tyr Asn Ile Asp Trp  Asn Val Pro 
    2870                 2875                 2880             


Glu Asn  Ile Asn Arg Ile Thr  Asn Ile Met Asp Asp  Pro Lys Tyr 
    2885                 2890                 2895             


Ser Ser  Asn Asn Leu Tyr Thr  Gly Thr Asp Leu Ile  Asn Asp Ser 
    2900                 2905                 2910             


Leu Asn  Gly Asn Gln Tyr Ile  Asp Ile Tyr Asp Glu  Met Leu Lys 
    2915                 2920                 2925             


Arg Lys  Glu Asn Glu Leu Phe  Gly Thr Tyr His Thr  Lys Tyr Thr 
    2930                 2935                 2940             


Thr Phe  Asn Ser Val Ser Lys  Gln Thr Pro Ser Asp  Pro Ile Ile 
    2945                 2950                 2955             


Asn Gln  Leu Asp Leu Tyr His  Lys Trp Ile Asp Lys  His Arg Asp 
    2960                 2965                 2970             


Ile Cys  Glu Gln Trp Lys Thr  Lys Glu Asp Met Leu  Tyr Lys Ser 
    2975                 2980                 2985             


Asn Glu  Val Trp Asn Met Glu  Arg Lys Glu Tyr Leu  Leu Asp Ile 
    2990                 2995                 3000             


Gln Pro  Ser Thr Leu Asp Asp  Ile His Lys Ile Asn  Asp Glu Thr 
    3005                 3010                 3015             


Tyr Asn  Ile Ile Ser Thr Asn  Asn Ile Tyr Asp His  Pro Ser Gln 
    3020                 3025                 3030             


Glu Thr  Pro Leu Gln Leu Leu  Gly Ser Thr Asn Ile  Ile Pro Ser 
    3035                 3040                 3045             


Tyr Ile  Thr Thr Glu Gln Asn  Asn Gly Leu Arg Thr  Asn Ile Ser 
    3050                 3055                 3060             


Met Asp  Thr Tyr Ile Asp Glu  Thr Asn Asn Asn Asn  Val Val Ala 
    3065                 3070                 3075             


Thr Ser  Ile Ile Gly Asp Asp  Gln Met Glu Asn Ser  Tyr Asn Cys 
    3080                 3085                 3090             


<210>  56
<211>  3111
<212>  PRT
<213>  Plasmodium falciparum

<400>  56

Met Asp Ser Thr Ser Thr Ile Gly Asp Lys Ile Glu Ala Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asn Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Lys Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn 
    50                  55                  60                  


Asp Pro Cys Glu Lys Lys Glu Leu Ser Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Asn Asn Lys Asn Ile 
                85                  90                  95      


Phe Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Lys 
            100                 105                 110         


Leu Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Ile Leu Tyr His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Ile Ala Asp Ile Ile Arg Gly Thr Asp Gln Leu Lys Gly Ser Asn 
                165                 170                 175     


Ile Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Lys 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Pro Asn Asp Asp Glu Asn Tyr Lys 
        195                 200                 205             


Lys Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Arg 
225                 230                 235                 240 


Trp Thr Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys Leu Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Leu Tyr 
        275                 280                 285             


Arg Glu Glu Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Lys Asn Val Glu Ser Asn Glu Gly Ala Ser Tyr Cys Asn 
305                 310                 315                 320 


Met Cys Lys Glu Lys His Thr Lys Tyr Cys Glu Cys Val Lys Lys Trp 
                325                 330                 335     


Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Glu 
            340                 345                 350         


Gln Glu Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
        355                 360                 365             


Val Lys Asp Phe Phe Glu Lys Leu Lys Gly Asn Gly Tyr Ser Ser Ala 
    370                 375                 380                 


Asn Ser Tyr Val Lys Asp Asp Pro Tyr Ser Ala Glu Tyr Val Thr Lys 
385                 390                 395                 400 


Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Thr Ser Ser Glu Thr 
                405                 410                 415     


Pro Ser Lys Tyr Tyr Asp Glu Val Cys Asn Cys Asn Glu Ser Glu Ile 
            420                 425                 430         


Ser Ser Val Gly Gln Ala Gln Thr Ser Gly Pro Ser Ser Asn Lys Thr 
        435                 440                 445             


Cys Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Val Cys Lys 
    450                 455                 460                 


Asp Val Lys Leu Gly Ile Asn Asn Asn Asp Lys Val Leu Arg Val Cys 
465                 470                 475                 480 


Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys Gln 
                485                 490                 495     


Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Lys Asn Gln Ser 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Asp Glu Cys 
        515                 520                 525             


Gln Lys Lys Leu Glu Lys Val Phe Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Cys Asp Lys Cys Lys Ser Gly Thr Ser Arg Ser Lys Lys Lys Trp Ile 
545                 550                 555                 560 


Trp Arg Lys Ser Ser Gly Asn Glu Glu Gly Leu Gln Lys Glu Tyr Ala 
                565                 570                 575     


Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Tyr Leu Gly Asn 
            580                 585                 590         


Leu Pro Lys Leu Glu Asn Val Cys Lys Gly Val Thr Asp Ile Ile Tyr 
        595                 600                 605             


Asp Thr Lys Glu Lys Phe Leu Ser Gly Cys Leu Ile Ala Ala Phe His 
    610                 615                 620                 


Glu Gly Lys Asn Leu Lys Thr Ser His Glu Lys Lys Asn Asp Asp Asn 
625                 630                 635                 640 


Gly Lys Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly 
                645                 650                 655     


Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Asp Phe Thr Lys Asp 
            660                 665                 670         


Leu Glu Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr 
        675                 680                 685             


Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp 
705                 710                 715                 720 


Thr Ala Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Ser Gly 
                725                 730                 735     


Asp Gly Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Met Pro Thr 
            740                 745                 750         


Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu 
        755                 760                 765             


His Phe Cys Lys Gln Arg Gln Glu Lys Val Lys Asp Val Ile Thr Asn 
    770                 775                 780                 


Cys Asn Ser Cys Lys Glu Cys Gly Asp Thr Cys Asn Gly Glu Cys Lys 
785                 790                 795                 800 


Thr Glu Cys Lys Thr Lys Cys Lys Gly Glu Cys Glu Lys Tyr Lys Asn 
                805                 810                 815     


Phe Ile Glu Glu Cys Asn Gly Thr Ala Asp Gly Gly Thr Ser Gly Ser 
            820                 825                 830         


Ser Trp Ser Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys Tyr 
        835                 840                 845             


Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly 
    850                 855                 860                 


Thr Ser Ser Thr Thr Asn Ala Ala Ala Ser Thr Thr Glu Asn Lys Cys 
865                 870                 875                 880 


Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly 
                885                 890                 895     


Leu Thr Thr Pro Ser Ser Tyr Leu Ser Asn Val Leu Asp Asp Asn Ile 
            900                 905                 910         


Cys Gly Glu Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr 
        915                 920                 925             


Lys Asn Cys Asp Ile Gln Lys Lys Thr Pro Lys Pro Gln Ser Cys Asp 
    930                 935                 940                 


Thr Leu Val Val Val Asn Val Pro Ser Pro Leu Gly Asn Thr Pro His 
945                 950                 955                 960 


Gly Tyr Lys Tyr Val Cys Glu Cys Lys Ile Pro Thr Thr Glu Glu Thr 
                965                 970                 975     


Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp Ile Ile Asp Thr Ser 
            980                 985                 990         


Lys Lys Gln Lys Gly Ser Gly Ser  Thr Asn Asn Asp Tyr  Glu Leu Tyr 
        995                 1000                 1005             


Thr Tyr  Asn Gly Val Gln Ile  Lys Gln Ala Ala Gly  Thr Leu Lys 
    1010                 1015                 1020             


Asn Ser  Lys Leu Asp Glu Asn  Asp Val Met Phe Phe  Asn Leu Phe 
    1025                 1030                 1035             


Glu Gln  Trp Asn Lys Glu Ile  Gln Tyr Gln Ile Glu  Gln Tyr Met 
    1040                 1045                 1050             


Thr Asn  Thr Lys Ile Ser Cys  Asn Asn Glu Lys Asn  Val Leu Ser 
    1055                 1060                 1065             


Arg Val  Ser Glu Glu Ser Gln  Asn Gln Asn Gly Ser  Asp His His 
    1070                 1075                 1080             


Asp Gly  Gly Asn Asn Asn Thr  Asp Gln Gly Thr Asn  Cys Lys Lys 
    1085                 1090                 1095             


Asn Cys  Glu Cys Tyr Glu Leu  Trp Ile Lys Lys Ile  Thr Glu Gln 
    1100                 1105                 1110             


Trp Glu  Thr Gln Lys Lys Asn  Tyr Asn Lys Phe Gln  Ser Lys Gln 
    1115                 1120                 1125             


Ile Tyr  Asp Gly Asn Asn Ala  Ser His Lys Lys Glu  Ile Val Lys 
    1130                 1135                 1140             


Leu Ser  His Phe Leu Phe Phe  Ser Cys Trp Glu Glu  Tyr Ile Gln 
    1145                 1150                 1155             


Lys Tyr  Phe Asn Gly Asp Trp  Ser Lys Ile Lys Asn  Ile Gly Ser 
    1160                 1165                 1170             


Asp Thr  Phe Glu Phe Leu Ile  Lys Lys Cys Gly Asn  Asn Ser Gly 
    1175                 1180                 1185             


Asp Gly  Glu Thr Ile Phe Ser  Glu Lys Leu Lys Asn  Ala Gln Gln 
    1190                 1195                 1200             


Gln Cys  Lys Glu Ile Gln Asn  Thr Asp Thr Lys Ile  Asn Pro Ser 
    1205                 1210                 1215             


Val Ile  Ser Ser Val Leu Asn  Ala Thr Asn Tyr Ile  Arg Gly Cys 
    1220                 1225                 1230             


Gln Pro  Lys Arg Tyr Asp Gly  Phe Ile Ser Pro Gly  Lys Gly Gly 
    1235                 1240                 1245             


Glu Lys  Gln Trp Ile Cys Lys  Asp Thr Ile Thr His  Gly Asp Thr 
    1250                 1255                 1260             


Asn Gly  Ala Cys Ile Pro Pro  Arg Thr Gln Asn Leu  Cys Val Gly 
    1265                 1270                 1275             


Glu Leu  Trp Tyr Lys Arg Tyr  Gly Gly Arg Ser Asn  Ile Lys Asn 
    1280                 1285                 1290             


Asp Thr  Lys Glu Ser Leu Lys  Asn Lys Leu Lys Asn  Ala Ile Gln 
    1295                 1300                 1305             


Lys Glu  Thr Glu Leu Leu Tyr  Glu Tyr His Asp Thr  Gly Thr Ala 
    1310                 1315                 1320             


Ile Ile  Ser Arg Asn Pro Met  Lys Glu Gly Gly Glu  Asp Gly Lys 
    1325                 1330                 1335             


Gly Lys  Gln Lys Glu Gly Gly  Glu Glu Ala Asn Asn  Asn Ser Asn 
    1340                 1345                 1350             


Gly Leu  Pro Lys Gly Phe Cys  His Ala Val Gln Arg  Ser Phe Ile 
    1355                 1360                 1365             


Asp Tyr  Lys Asn Met Ile Leu  Gly Thr Ser Val Asn  Ile Tyr Glu 
    1370                 1375                 1380             


Tyr Ile  Gly Lys Leu Gln Glu  Asp Ile Lys Lys Ile  Ile Glu Gln 
    1385                 1390                 1395             


Glu Arg  Thr Lys Thr Lys Asp  Lys Ile Gly Gly Ser  Gly Ala Asp 
    1400                 1405                 1410             


Lys Val  Asn Asp Trp Trp Lys  Gly Ile Glu Gly Glu  Met Trp Asp 
    1415                 1420                 1425             


Ala Val  Lys Cys Ala Ile Thr  Lys Ile Lys Lys Gln  Lys Lys Asn 
    1430                 1435                 1440             


Gly Thr  Tyr Thr Gly Asn Glu  Cys Gly Val Ser Pro  Pro Thr Gly 
    1445                 1450                 1455             


Asn Asp  Glu Asp Gln Ser Val  Ser Trp Phe Lys Glu  Trp Gly Glu 
    1460                 1465                 1470             


Gln Phe  Cys Ile Glu Arg Leu  Arg Tyr Glu Gln Asn  Ile Arg Glu 
    1475                 1480                 1485             


Ala Cys  Thr Ile Asn Gly Lys  Asn Glu Lys Lys Cys  Ile Asn Ser 
    1490                 1495                 1500             


Lys Ser  Gly Gln Glu Asp Lys  Val Glu Gly Ala Cys  Lys Arg Lys 
    1505                 1510                 1515             


Cys Glu  Lys Tyr Lys Lys Tyr  Ile Ser Glu Lys Lys  Gln Glu Trp 
    1520                 1525                 1530             


Asp Lys  Gln Lys Thr Lys Tyr  Glu Asn Lys Tyr Val  Gly Lys Ser 
    1535                 1540                 1545             


Ala Ser  Asp Leu Leu Lys Glu  Asn Tyr Pro Glu Cys  Ile Ser Ala 
    1550                 1555                 1560             


Asn Phe  Asp Phe Ile Phe Asn  Asp Lys Ala Asp His  Lys Lys Tyr 
    1565                 1570                 1575             


Tyr Pro  Tyr Gly Asp Tyr Ser  Ser Ile Cys Ser Cys  Glu Gln Val 
    1580                 1585                 1590             


Lys Tyr  Tyr Lys Tyr Asn Asn  Ala Glu Lys Lys Asn  Asn Lys Ser 
    1595                 1600                 1605             


Leu Cys  His Glu Lys Gly Asn  Asp Arg Thr Trp Ser  Lys Lys Tyr 
    1610                 1615                 1620             


Ile Lys  Lys Leu Glu Asn Gly  Arg Ser Leu Glu Gly  Val Tyr Val 
    1625                 1630                 1635             


Pro Pro  Arg Arg Gln Gln Leu  Cys Leu Tyr Glu Leu  Phe Pro Ile 
    1640                 1645                 1650             


Ile Ile  Lys Asn Glu Glu Gly  Met Glu Lys Ala Lys  Glu Glu Leu 
    1655                 1660                 1665             


Leu Glu  Thr Leu Gln Ile Val  Ala Glu Arg Glu Ala  Tyr Tyr Leu 
    1670                 1675                 1680             


Trp Lys  Gln Tyr Asn Pro Thr  Gly Lys Gly Ile Asp  Asp Ala Asn 
    1685                 1690                 1695             


Lys Lys  Ala Cys Cys Ala Ile  Arg Gly Ser Phe Tyr  Asp Leu Glu 
    1700                 1705                 1710             


Asp Ile  Ile Lys Gly Asn Asp  Leu Val His Asp Glu  Tyr Thr Lys 
    1715                 1720                 1725             


Tyr Ile  Asp Ser Lys Leu Asn  Glu Ile Phe Gly Ser  Ser Asn Lys 
    1730                 1735                 1740             


Asn Asp  Ile Asp Thr Lys Arg  Ala Arg Thr Asp Trp  Trp Glu Asn 
    1745                 1750                 1755             


Glu Thr  Ile Asp Val Ala Asn  Gly Thr Asp His Lys  Thr Ile Arg 
    1760                 1765                 1770             


Gln Leu  Val Trp Asp Ala Met  Gln Ser Gly Val Arg  Lys Ala Ile 
    1775                 1780                 1785             


Asp Glu  Glu Asn Glu Lys Lys  Lys Gln Asn Lys Asn  Phe Pro Pro 
    1790                 1795                 1800             


Cys Met  Gly Val Glu His Ile  Gly Ile Ala Lys Pro  Gln Phe Ile 
    1805                 1810                 1815             


Arg Trp  Leu Glu Glu Trp Thr  Asn Glu Phe Cys Glu  Glu Tyr Thr 
    1820                 1825                 1830             


Lys Tyr  Phe Gly Ala Ile Asn  Ser Asn Cys Asn Arg  Arg Lys Gly 
    1835                 1840                 1845             


Ala Asp  Asp Cys Gly Asp Asn  Ser Asn Ile Glu Cys  Lys Arg Ala 
    1850                 1855                 1860             


Cys Ala  Asn Tyr Thr Asn Trp  Leu Asn Pro Lys Arg  Ile Glu Trp 
    1865                 1870                 1875             


Asn Gly  Met Ser Asn Tyr Tyr  Asn Lys Ile Tyr Arg  Lys Ser Asn 
    1880                 1885                 1890             


Lys Glu  Ser Glu Asp Gly Lys  Asp Tyr Ser Met Ile  Met Ala Pro 
    1895                 1900                 1905             


Thr Val  Ile Asp Tyr Leu Asn  Lys Arg Cys Asn Gly  Glu Ile Asn 
    1910                 1915                 1920             


Gly Asn  Tyr Ile Cys Cys Ser  Cys Lys Asn Ile Gly  Glu Asn Tyr 
    1925                 1930                 1935             


Asn Pro  Ser Pro Ala Gln Lys  Thr Lys Gly Ser Lys  Lys Lys Asp 
    1940                 1945                 1950             


Glu Gln  Cys Glu Asp Asn Lys  Gly Pro Leu Asp Leu  Met Asn Glu 
    1955                 1960                 1965             


Val Leu  Asn Lys Met Asp Glu  Lys Tyr Ser Ala His  Lys Met Lys 
    1970                 1975                 1980             


Cys Thr  Glu Phe Tyr Leu Glu  His Val Glu Glu Gln  Leu Lys Glu 
    1985                 1990                 1995             


Ile Asp  Asn Ala Ile Lys Asp  Tyr Lys Leu Tyr Pro  Leu Asp Arg 
    2000                 2005                 2010             


Cys Phe  Asp Asp Lys Ser Lys  Met Lys Val Cys Asp  Leu Ile Ala 
    2015                 2020                 2025             


Asp Ala  Ile Gly Cys Lys Asp  Lys Thr Lys Leu Asp  Glu Leu Asp 
    2030                 2035                 2040             


Glu Trp  Asn Asp Val Asp Met  Arg Gly Thr Tyr Asn  Lys His Lys 
    2045                 2050                 2055             


Gly Val  Leu Ile Pro Pro Arg  Arg Arg Gln Leu Cys  Phe Ser Arg 
    2060                 2065                 2070             


Ile Val  Arg Gly Pro Ala Asn  Leu Arg Ser Leu Asn  Glu Phe Lys 
    2075                 2080                 2085             


Glu Glu  Ile Leu Lys Gly Ala  Gln Ser Glu Gly Lys  Phe Leu Gly 
    2090                 2095                 2100             


Asn Tyr  Tyr Asn Glu Asp Lys  Gly Lys Glu Lys Lys  Glu Asp Arg 
    2105                 2110                 2115             


Lys Glu  Lys Ala Leu Glu Ala  Met Lys Asn Ser Phe  Tyr Asp Tyr 
    2120                 2125                 2130             


Glu Asp  Ile Ile Lys Gly Thr  Asp Met Leu Thr Asn  Ile Glu Phe 
    2135                 2140                 2145             


Lys Asp  Ile Lys Met Lys Leu  Asp Lys Leu Leu Thr  Lys Glu Thr 
    2150                 2155                 2160             


Asn Asn  Thr Lys Lys Ala Glu  Asp Trp Trp Lys Thr  Asn Lys Lys 
    2165                 2170                 2175             


Ser Ile  Trp Asn Ala Met Leu  Cys Gly Tyr Lys Lys  Ser Gly Asn 
    2180                 2185                 2190             


Lys Ile  Ile Asp Arg Ser Trp  Cys Thr Ile Pro Thr  Thr Glu Thr 
    2195                 2200                 2205             


Pro Pro  Gln Phe Leu Arg Trp  Ile Lys Glu Trp Gly  Lys Asn Val 
    2210                 2215                 2220             


Cys Ile  Gln Lys Glu Lys Tyr  Lys Gln Asn Val Lys  Ser Glu Cys 
    2225                 2230                 2235             


Ser Asn  Val Ser Asn Ile Asp  Leu Asp Pro Gln Ala  Ser Glu Ser 
    2240                 2245                 2250             


Asn Asn  Cys Thr Ser Glu Ile  Arg Lys Tyr Gln Glu  Leu Ile Arg 
    2255                 2260                 2265             


Lys Arg  Ser Ile Gln Trp Glu  Ala Ile Ser Glu Arg  Tyr Arg Lys 
    2270                 2275                 2280             


Tyr Lys  Gly Met Asp Val Leu  Lys Asn Val Lys Glu  Pro Asp Ala 
    2285                 2290                 2295             


Asn Glu  Tyr Leu Lys Glu His  Cys Ser Lys Cys Pro  Cys Gly Phe 
    2300                 2305                 2310             


Asn Asp  Met Glu Glu Ile Ser  Asn Asn Glu Asp Asn  Glu Lys Glu 
    2315                 2320                 2325             


Thr Phe  Asn Arg Ile Ile Glu  Lys Val Lys Ile Pro  Ala Glu Leu 
    2330                 2335                 2340             


Glu Asp  Val Ile Tyr Arg Leu  Lys His His Lys Tyr  Asn Ser Asn 
    2345                 2350                 2355             


Asp Tyr  Ile Cys Asn Lys Tyr  Lys Asn Ile Asn Val  Asn Met Lys 
    2360                 2365                 2370             


Lys Asn  Asn Asp Asn Ile Trp  Thr Asp Leu Leu Val  Lys Asn Ser 
    2375                 2380                 2385             


Ser Asp  Ile Asn Lys Gly Val  Leu Ile Pro Pro Arg  Arg Lys Asn 
    2390                 2395                 2400             


Leu Phe  Leu Asn Ile Glu Lys  Ser Asp Ile Cys Lys  Tyr Lys Lys 
    2405                 2410                 2415             


Asn Pro  Lys Leu Phe Asn Asp  Phe Ile Tyr Ser Ser  Ala Ile Ser 
    2420                 2425                 2430             


Glu Val  Glu Arg Leu Lys Lys  Val Tyr Gly Glu Ala  Arg Ala Lys 
    2435                 2440                 2445             


Val Ala  Asn Ala Met Lys Tyr  Ser Phe Ala Asp Ile  Gly Asn Ile 
    2450                 2455                 2460             


Ile Lys  Gly Asp Asp Met Met  Lys Ser Pro Thr Ser  Lys Tyr Ile 
    2465                 2470                 2475             


Glu Gln  Ile Phe Lys Gly Thr  Glu Tyr Ser Gly Ile  Asp Ser Glu 
    2480                 2485                 2490             


Thr Trp  Trp Asp Met Asn Lys  Tyr His Ile Trp Glu  Ser Met Leu 
    2495                 2500                 2505             


Cys Gly  Tyr Lys Gln Ala Gly  Gly Asp Thr Lys Thr  Asn Glu Asn 
    2510                 2515                 2520             


Cys Arg  Phe Pro Asp Thr Asp  Gly Val Pro Gln Phe  Leu Arg Trp 
    2525                 2530                 2535             


Phe Gln  Glu Trp Thr Glu Lys  Phe Cys Asp Ser Arg  Gln Lys Leu 
    2540                 2545                 2550             


Tyr Glu  Lys Leu Asn Asn Asp  Cys Lys Ser Val Glu  Cys Asn Thr 
    2555                 2560                 2565             


Ser Asn  Gly Thr Ile Gly Asn  Asn Cys Thr Ile Ala  Cys Gln Glu 
    2570                 2575                 2580             


Tyr Ser  Asn Tyr Ile Ser Arg  Lys Lys Asp Glu Tyr  Leu Ser Leu 
    2585                 2590                 2595             


Lys Ser  His Tyr Asp Met Asn  Tyr Arg Thr Ser Lys  Lys Gly Ile 
    2600                 2605                 2610             


Thr Glu  Ala His Glu Tyr Leu  Lys Glu Glu Cys Arg  Asn Asn Cys 
    2615                 2620                 2625             


Glu Cys  Phe Leu Asn His Ile  Asp Asp Lys Lys Lys  Thr Trp Lys 
    2630                 2635                 2640             


Asn Thr  Tyr Glu Thr Leu Glu  Glu Thr Leu Lys Gly  Lys Cys Glu 
    2645                 2650                 2655             


Cys Lys  Lys Ile Glu Pro Lys  Ile Ser Pro Asp Ile  Ser Thr Glu 
    2660                 2665                 2670             


Pro Glu  Tyr Pro Pro Ser Asp  Pro Lys Pro Ala Thr  Pro Leu Pro 
    2675                 2680                 2685             


Pro Gln  Asn Asp Glu Pro Ile  Asn Ser Asn Ile Leu  Ser Ser Thr 
    2690                 2695                 2700             


Ile Pro  Leu Gly Ile Ala Leu  Ala Leu Ser Ser Ile  Ala Phe Leu 
    2705                 2710                 2715             


Phe Leu  Lys Lys Lys Pro Lys  Ser Pro Val Asp Leu  Leu Arg Val 
    2720                 2725                 2730             


Leu Asp  Ile His Lys Gly Asp  Tyr Gly Ile Pro Thr  Pro Lys Ser 
    2735                 2740                 2745             


Ser Asn  Arg Tyr Ile Pro Tyr  Val Ser Asp Thr Tyr  Lys Gly Lys 
    2750                 2755                 2760             


Thr Tyr  Ile Tyr Met Glu Gly  Asp Thr Ser Gly Asp  Asp Asp Lys 
    2765                 2770                 2775             


Tyr Ala  Phe Met Ser Asp Thr  Thr Asp Ile Thr Ser  Ser Glu Ser 
    2780                 2785                 2790             


Glu Tyr  Glu Glu Met Glu Ile  Asn Asp Ile Tyr Val  Pro Gly Ser 
    2795                 2800                 2805             


Pro Lys  Tyr Lys Thr Leu Ile  Glu Val Val Leu Glu  Pro Ser Lys 
    2810                 2815                 2820             


Arg Asp  Ile Gln Ser Asp Asp  Ile Pro Asn Asn Asp  Thr Pro Thr 
    2825                 2830                 2835             


Asn Lys  Phe Thr Asp Asn Glu  Trp Asn Gln Leu Lys  Lys Asp Phe 
    2840                 2845                 2850             


Ile Ser  Asn Met Leu Gln Asn  Thr Gln Asn Thr Glu  Pro Asn Ile 
    2855                 2860                 2865             


Leu Arg  Asp Asn Val Asp Asn  Asn Thr His Pro Thr  Met Ser Arg 
    2870                 2875                 2880             


Asp Asn  Met Glu Glu Lys Pro  Phe Ile Thr Ser Ile  His Asp Arg 
    2885                 2890                 2895             


Asn Leu  Tyr Ser Gly Glu Glu  Tyr Asn Tyr Asn Ile  Asn Met Val 
    2900                 2905                 2910             


Asn Asn  Asp Asp Ile Pro Ile  Asn Arg Asp Asn Asn  Val Tyr Ser 
    2915                 2920                 2925             


Gly Ile  Asp Leu Ile Asn Asp  Ser Leu Ser Gly Gly  Glu Pro Ile 
    2930                 2935                 2940             


Asp Ile  Tyr Asp Glu Val Leu  Lys Arg Lys Glu Asn  Glu Leu Phe 
    2945                 2950                 2955             


Gly Thr  Asn His Val Lys Gln  Thr Ser Ile His Ser  Val Ala Lys 
    2960                 2965                 2970             


Leu Thr  Asn Ser Asp Pro Ile  His Asn Gln Leu Glu  Leu Phe His 
    2975                 2980                 2985             


Lys Trp  Leu Asp Arg His Arg  Asp Met Asp Lys Trp  Lys Asn Lys 
    2990                 2995                 3000             


Asp Ile  Leu His Lys Leu Asn  Glu Glu Trp Thr Ile  Glu His Asn 
    3005                 3010                 3015             


Glu Asp  Leu Leu Asp Ile Pro  Ser Ser Ser His Asp  Asp Ile Leu 
    3020                 3025                 3030             


Lys Ile  Lys Asp Glu Thr Tyr  Asn Ile Ile Ser Thr  Asn Asn Leu 
    3035                 3040                 3045             


Tyr Ser  Tyr Glu Asn Asn Asp  Ile Thr Pro His Gln  Leu Gly Leu 
    3050                 3055                 3060             


Pro Asn  Ile Ile Pro Ser Gly  Ile Ile Lys His Gln  Asn Asn Gly 
    3065                 3070                 3075             


Leu Arg  Thr Asn Ile Ser Met  Asp Ile Pro Phe Asp  Glu Gln Asn 
    3080                 3085                 3090             


Asn Asn  Leu Glu Asn Ser Asn  Ile Thr Tyr Glu Asp  Asp Glu Val 
    3095                 3100                 3105             


Gln Asn  Ser 
    3110     


<210>  57
<211>  3073
<212>  PRT
<213>  Plasmodium falciparum

<400>  57

Met Asp Ser Thr Ser Thr Ile Gly Asp Lys Ile Glu Glu Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asn Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Lys Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Glu Pro Cys Asp Ser Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Asp Glu Asn Leu Phe Lys Ala Ser Gly Asn His Lys Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Gln His Met Cys Ile Lys Asn Leu Glu Asn 
            100                 105                 110         


Leu Lys Phe Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Ile Leu Tyr His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Ile Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Lys Phe Glu Pro Tyr Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Lys 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Gln Asn Asp Asp Glu Asn Tyr Lys 
        195                 200                 205             


Lys Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Arg 
225                 230                 235                 240 


Trp Arg Thr Ser Gly Lys Ser Asn Gly Glu Asn Lys Leu Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Tyr Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Leu Tyr 
        275                 280                 285             


Arg Glu Glu Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Lys Asn Val Asp Ser Lys Glu Gly Thr Ser Tyr Cys Asn 
305                 310                 315                 320 


Met Cys Lys Glu Lys His Thr Lys Tyr Cys Glu Phe Val Asn Lys Trp 
                325                 330                 335     


Lys Ser Glu Trp Lys Asn Gln Glu Asn Lys Tyr Lys Asp Leu Tyr Gln 
            340                 345                 350         


Gln Glu Asn Lys Thr Ser Ser Ser Ser Lys Asn Thr Ser Arg Tyr Asp 
        355                 360                 365             


Asn Tyr Val Lys Glu Phe Phe Glu Lys Leu Glu Ala Asn Tyr Lys Ser 
    370                 375                 380                 


Leu Glu Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Val Thr 
385                 390                 395                 400 


Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Thr Ser Ser Gly 
                405                 410                 415     


Glu Thr Ala Asn His Asn Asp Glu Ala Cys Asn Arg Asn Glu Ser Glu 
            420                 425                 430         


Ile Ser Ser Val Glu Gln Ala Pro Ile Ser Gly Pro Ser Ser Asn Lys 
        435                 440                 445             


Thr Cys Asn Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Glu Cys 
    450                 455                 460                 


Lys Asp Val Lys Leu Gly Ile Asn Asn Asn Asp Lys Asp Leu Lys Ile 
465                 470                 475                 480 


Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys 
                485                 490                 495     


Gln Asp Phe Leu Arg Met Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asp Asn Lys Asn Gln Asp Glu Cys 
        515                 520                 525             


Gln Thr Lys Leu Asp Glu Ala Leu Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Cys Glu Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Asn Gln Trp 
545                 550                 555                 560 


Ile Trp Lys Lys Ser Arg Gly Thr Glu Gly Gly Leu Gln Glu Glu Tyr 
                565                 570                 575     


Ala Asn Thr Ile Ala Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val 
            580                 585                 590         


Cys Leu His Glu Lys Glu Glu Lys Thr Gln His Lys Thr Ile Ser Thr 
        595                 600                 605             


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
    610                 615                 620                 


Lys Asn Leu Lys Lys Arg Tyr His Gln Asn Lys Asn Ala Asp Asn Glu 
625                 630                 635                 640 


Lys Lys Lys Gly Glu Asn Lys Lys Lys Leu Cys Lys Ala Leu Lys Tyr 
                645                 650                 655     


Ser Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp 
            660                 665                 670         


Asn Glu Tyr Thr Lys Asp Leu Glu Leu Asn Leu Gln Gln Ile Phe Gly 
        675                 680                 685             


Lys Leu Phe Arg Lys Tyr Ile Lys Lys Asn Ile Ser Thr Glu Gln Asp 
    690                 695                 700                 


Thr Leu Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr 
705                 710                 715                 720 


Asn Lys Lys Tyr Ile Trp Leu Ala Met Lys His Gly Ala Glu Met Asn 
                725                 730                 735     


Gly Thr Thr Cys Cys Gly Asp Gly Ser Ser Gly Glu Asn Gln Thr Asn 
            740                 745                 750         


Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg 
        755                 760                 765             


Phe Leu Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg Gln Glu Asn 
    770                 775                 780                 


Val Asn Ala Val Ile Glu Asn Cys Lys Ser Cys Lys Glu Cys Gly Gly 
785                 790                 795                 800 


Thr Cys Gly Ser Asp Cys Lys Thr Glu Cys Glu Lys Lys Cys Lys Ala 
                805                 810                 815     


Tyr Lys Glu Phe Ile Glu Lys Cys Glu Gly Gln Ala Ala Glu Gly Thr 
            820                 825                 830         


Ser Gly Tyr Ser Trp Ser Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr 
        835                 840                 845             


Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys 
    850                 855                 860                 


Asn Cys Gly Thr Ser Ser Gly Ala Thr Ser Gly Val Thr Thr Thr Glu 
865                 870                 875                 880 


Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile 
                885                 890                 895     


Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp 
            900                 905                 910         


Asp Asn Ile Cys Gly Ala Asp Asn Ala Pro Trp Thr Thr Tyr Thr Thr 
        915                 920                 925             


Tyr Thr Thr Lys Asn Cys Asp Lys Glu Lys Asp Lys Ser Lys Ser Gln 
    930                 935                 940                 


Ser Cys Asp Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
945                 950                 955                 960 


Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro Thr Thr 
                965                 970                 975     


Glu Glu Ser Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp Ile Ile 
            980                 985                 990         


Asp Asn Thr Lys Asn Pro Lys Gly  Ser Arg Ser Thr Asn  Asn Asp Tyr 
        995                 1000                 1005             


Glu Leu  Tyr Thr Tyr Asn Gly  Val Lys Glu Thr Lys  Leu Pro Lys 
    1010                 1015                 1020             


Lys Leu  Asn Ser Ser Lys Leu  Asp Glu Asn Asp Val  Thr Phe Phe 
    1025                 1030                 1035             


Asn Leu  Phe Glu Gln Trp Asn  Lys Glu Ile Gln Tyr  Gln Ile Glu 
    1040                 1045                 1050             


Gln Tyr  Met Thr Asn Thr Lys  Ile Ser Cys Asn Asn  Glu Lys Asn 
    1055                 1060                 1065             


Val Leu  Ser Ser Ser Ser Glu  Glu Ser Lys Asn Gln  Asn Gly Ser 
    1070                 1075                 1080             


Asp His  His Asp Gly Gly Asn  Asn Asn Ile Asn Gln  Gly Thr Asn 
    1085                 1090                 1095             


Cys Lys  Glu Lys Cys Glu Cys  Tyr Glu Leu Trp Ile  Lys Lys Ile 
    1100                 1105                 1110             


Lys Glu  Gln Trp Asp Lys Gln  Lys Asn Asn Tyr Asn  Lys Phe Gln 
    1115                 1120                 1125             


Ser Lys  Gln Ile Tyr Asp Ala  Arg Lys Ser Ser Gln  Asn Lys Lys 
    1130                 1135                 1140             


Glu Ile  Val Lys Leu Ser His  Phe Leu Phe Phe Ser  Cys Trp Glu 
    1145                 1150                 1155             


Glu Tyr  Ile Gln Lys Tyr Phe  Asn Gly Asp Trp Ser  Lys Ile Lys 
    1160                 1165                 1170             


Asn Ile  Gly Ser Asp Thr Phe  Glu Phe Leu Ile Lys  Lys Cys Gly 
    1175                 1180                 1185             


Asn Asn  Ser Gly Asp Gly Glu  Thr Ile Phe Ser Glu  Lys Leu Lys 
    1190                 1195                 1200             


Asn Ala  His Ile Lys Cys Lys  Glu Asn Glu Ser Thr  Asp Thr Lys 
    1205                 1210                 1215             


Ile Asn  Lys Ser Glu Thr Ser  Ser Lys Cys Asn Lys  Thr Asn Tyr 
    1220                 1225                 1230             


Ile Arg  Gly Cys Gln Ser Lys  Arg Tyr Asp Gly Lys  Ile Phe Pro 
    1235                 1240                 1245             


Gly Lys  Gly Gly Glu Lys Gln  Trp Ile Cys Lys Asp  Thr Ile Thr 
    1250                 1255                 1260             


His Gly  Asp Thr Asn Gly Ala  Cys Ile Pro Pro Arg  Thr Gln Asn 
    1265                 1270                 1275             


Leu Cys  Val Gly Glu Leu Trp  Asp Lys Ser Tyr Gly  Gly Arg Ser 
    1280                 1285                 1290             


Asn Ile  Lys Asn Asp Thr Lys  Glu Leu Leu Lys Asn  Lys Leu Lys 
    1295                 1300                 1305             


Asn Ala  Ile Gln Lys Glu Thr  Glu Leu Leu Tyr Glu  Tyr His Asp 
    1310                 1315                 1320             


Lys Gly  Thr Ala Ile Ile Ser  Gln Asn Asp Lys Lys  Gly Gln Lys 
    1325                 1330                 1335             


Gly Lys  Asn Asp Pro Asn Gly  Leu Pro Lys Gly Phe  Cys His Ala 
    1340                 1345                 1350             


Val Gln  Arg Ser Phe Ile Asp  Tyr Lys Asn Met Ile  Leu Gly Thr 
    1355                 1360                 1365             


Ser Val  Asn Thr Tyr Glu Tyr  Ile Gly Lys Leu Gln  Glu Asp Ile 
    1370                 1375                 1380             


Lys Lys  Ile Ile Glu Lys Gly  Thr Thr Lys Gln Asn  Gly Lys Thr 
    1385                 1390                 1395             


Val Gly  Ser Gly Ala Asp Lys  Val Asn Asp Trp Trp  Lys Glu Ile 
    1400                 1405                 1410             


Glu Lys  Asp Met Trp Gly Ala  Val Lys Ser Gly Ile  Lys Thr Ile 
    1415                 1420                 1425             


Lys Lys  Gln Asn Asn Lys Cys  Thr Tyr Thr Gly Asn  Glu Cys Gly 
    1430                 1435                 1440             


Val Ser  Pro Pro Thr Gly Asn  Asp Glu Asp Gln Phe  Val Ser Trp 
    1445                 1450                 1455             


Phe Lys  Glu Trp Gly Glu Gln  Phe Cys Ile Glu Arg  Leu Gln Tyr 
    1460                 1465                 1470             


Glu Gln  Asn Ile Arg Asp Ala  Cys Thr Asn Asn Gly  Lys Asn Glu 
    1475                 1480                 1485             


Lys Lys  Cys Ile Asn Ser Lys  Asn Asn Asn Glu Lys  Glu Ile Gln 
    1490                 1495                 1500             


Gly Asp  Cys Lys Arg Lys Cys  Glu Glu Tyr Lys Lys  Tyr Ile Ser 
    1505                 1510                 1515             


Glu Lys  Lys Gln Glu Trp Asp  Lys Gln Lys Thr Lys  Tyr Glu Asn 
    1520                 1525                 1530             


Lys Tyr  Val Gly Lys Ser Ala  Ser Asp Leu Leu Lys  Glu Asn Tyr 
    1535                 1540                 1545             


Pro Glu  Cys Ile Ser Ala Asn  Phe Asp Phe Ile Phe  Asn Asp Asn 
    1550                 1555                 1560             


Ile Glu  Tyr Lys Thr Tyr Tyr  Pro Tyr Gly Asp Tyr  Ser Ser Ile 
    1565                 1570                 1575             


Cys Ser  Cys Glu Gln Val Lys  Tyr Tyr Lys Tyr Asn  Asn Ala Glu 
    1580                 1585                 1590             


Lys Lys  Asn Asn Lys Ser Leu  Cys His Glu Lys Gly  Asn Asp Arg 
    1595                 1600                 1605             


Thr Trp  Ser Lys Lys Tyr Ile  Lys Lys Leu Glu Asn  Gly Arg Thr 
    1610                 1615                 1620             


Leu Glu  Gly Val Tyr Val Pro  Pro Arg Arg Gln Gln  Leu Cys Leu 
    1625                 1630                 1635             


Tyr Glu  Leu Phe Pro Ile Ile  Ile Lys Lys Glu Lys  Asp Met Glu 
    1640                 1645                 1650             


Lys Ala  Lys Glu Leu Leu Glu  Thr Leu Gln Ile Val  Ala Glu Arg 
    1655                 1660                 1665             


Glu Ala  Tyr Tyr Leu Trp Lys  Gln Tyr Asn Pro Thr  Gly Lys Gly 
    1670                 1675                 1680             


Ile Asp  Asp Ala Asn Lys Lys  Ala His Lys Lys Ala  Cys Cys Ala 
    1685                 1690                 1695             


Ile Arg  Gly Ser Phe Tyr Asp  Leu Glu Asp Ile Ile  Lys Gly Asn 
    1700                 1705                 1710             


Asp Leu  Val His Asp Glu Tyr  Thr Lys Tyr Ile Asp  Ser Lys Leu 
    1715                 1720                 1725             


Asn Glu  Ile Phe Gly Ser Ser  Asn Thr Asn Asp Ile  Glu Thr Lys 
    1730                 1735                 1740             


Arg Ala  Arg Thr Asp Trp Trp  Glu Asn Glu Thr Ile  Gly Val Ala 
    1745                 1750                 1755             


Asn Gly  Thr Asp Ser Lys Thr  Ile Arg Gln Leu Val  Trp Asp Ala 
    1760                 1765                 1770             


Met Gln  Ser Gly Val Ile Tyr  Ala Glu Glu Lys Lys  Glu Asn Phe 
    1775                 1780                 1785             


Pro Pro  Cys Met Arg Val Glu  His Ile Gly Ile Ala  Lys Pro Gln 
    1790                 1795                 1800             


Phe Ile  Arg Trp Leu Glu Glu  Trp Thr Asn Glu Phe  Cys Glu Lys 
    1805                 1810                 1815             


Tyr Thr  Lys Tyr Phe Glu Asp  Met Lys Ser Lys Cys  Asp Pro Pro 
    1820                 1825                 1830             


Lys Gly  Ala Asp Asp Cys Asp  Asp Asn Ser Asn Ile  Glu Cys Lys 
    1835                 1840                 1845             


Arg Ala  Cys Ala Asn Tyr Thr  Asn Trp Leu Asn Pro  Lys Arg Ile 
    1850                 1855                 1860             


Glu Trp  Asn Gly Met Ser Asn  Tyr Tyr Asn Lys Ile  Tyr Arg Lys 
    1865                 1870                 1875             


Ser Asn  Lys Glu Ser Glu Asp  Gly Lys Asp Tyr Ser  Met Ile Met 
    1880                 1885                 1890             


Glu Pro  Thr Val Ile Asp Tyr  Leu Asn Lys Arg Cys  His Gly Glu 
    1895                 1900                 1905             


Ile Asn  Gly Asn Tyr Ile Cys  Cys Ser Cys Lys Asn  Ile Gly Glu 
    1910                 1915                 1920             


Asn Ser  Thr Ser Gly Thr Val  Asn Lys Lys Leu Gln  Lys Lys Glu 
    1925                 1930                 1935             


Thr Glu  Cys Glu Asp Asn Lys  Gly Pro Leu Asp Leu  Met Asn Glu 
    1940                 1945                 1950             


Val Leu  Asn Lys Met Asp Lys  Lys Tyr Ser Ala His  Lys Met Lys 
    1955                 1960                 1965             


Cys Thr  Glu Val Tyr Leu Glu  His Val Glu Glu Gln  Leu Lys Glu 
    1970                 1975                 1980             


Ile Asp  Asn Ala Ile Lys Asp  Tyr Lys Leu Tyr Pro  Leu Asp Arg 
    1985                 1990                 1995             


Cys Phe  Asp Asp Gln Thr Lys  Met Lys Val Cys Asp  Leu Ile Gly 
    2000                 2005                 2010             


Asp Ala  Ile Gly Cys Lys Asp  Lys Thr Asn Leu Glu  Glu Leu Asp 
    2015                 2020                 2025             


Glu Trp  Asn Asp Met Asp Leu  Arg Asp Pro Tyr Asn  Lys Tyr Lys 
    2030                 2035                 2040             


Gly Val  Leu Ile Pro Pro Arg  Arg Arg Gln Leu Cys  Phe Ser Arg 
    2045                 2050                 2055             


Ile Val  Arg Gly Arg Ala Asn  Leu Arg Asn Leu Asn  Glu Phe Lys 
    2060                 2065                 2070             


Glu Glu  Ile Leu Lys Gly Ala  Gln Ser Glu Gly Lys  Phe Leu Gly 
    2075                 2080                 2085             


Asn Tyr  Tyr Lys Glu His Lys  Gly Asn Tyr Tyr Lys  Glu His Lys 
    2090                 2095                 2100             


Asp Lys  Glu Lys Ala Leu Glu  Ala Met Lys Asn Ser  Phe Tyr Asp 
    2105                 2110                 2115             


Tyr Glu  Tyr Ile Ile Lys Gly  Thr Asp Met Leu Ala  Asn Ile Gln 
    2120                 2125                 2130             


Phe Lys  Asp Ile Lys Ile Lys  Leu Asp Lys Leu Leu  Thr Lys Glu 
    2135                 2140                 2145             


Thr Asn  Asn Asn Thr Lys Lys  Ala Glu Asp Trp Trp  Lys Val Asn 
    2150                 2155                 2160             


Asn Lys  Ser Ile Trp Asn Ala  Met Leu Cys Gly Tyr  Lys Lys Ser 
    2165                 2170                 2175             


Gly Asn  Lys Ile Ile Asp Pro  Ser Trp Cys Thr Ile  Pro Thr Thr 
    2180                 2185                 2190             


Glu Lys  Thr Pro Gln Phe Leu  Arg Trp Ile Lys Glu  Trp Gly Thr 
    2195                 2200                 2205             


Asn Val  Cys Ile Glu Lys Glu  Lys Tyr Lys Glu Tyr  Val Lys Ser 
    2210                 2215                 2220             


Lys Cys  Ser Asn Val Thr Asn  Ile Asp Leu Asp Pro  Gln Ala Ser 
    2225                 2230                 2235             


Glu Ser  Lys Asn Cys Thr Ser  Glu Ile Arg Lys Tyr  Gln Glu Trp 
    2240                 2245                 2250             


Ser Arg  Asn Arg Tyr Val Gln  Trp Glu Ala Ile Ser  Glu Arg Tyr 
    2255                 2260                 2265             


Lys Lys  Tyr Lys Arg Met Asp  Glu Phe Lys Asn Thr  Phe Lys Asn 
    2270                 2275                 2280             


Ile Lys  Glu His Asp Ala Asn  Glu Tyr Leu Lys Glu  His Cys Ser 
    2285                 2290                 2295             


Lys Cys  Pro Cys Gly Phe Asn  Asp Met Gln Glu Ile  Thr Lys Tyr 
    2300                 2305                 2310             


Thr Asn  Ile Gly Asn Glu Ala  Phe Lys Gln Ile Lys  Glu Gln Val 
    2315                 2320                 2325             


Asp Ile  Pro Ala Glu Leu Glu  Asp Val Ile Tyr Arg  Leu Lys His 
    2330                 2335                 2340             


His Lys  Tyr Asn Ser Asn Asp  Tyr Ile Cys Arg Lys  Tyr Asn Asn 
    2345                 2350                 2355             


Lys Asn  Leu Tyr Ser Arg Met  Gln His Asn Ile Asp  Thr Ile Trp 
    2360                 2365                 2370             


Thr Asp  Leu Val Lys Asn Ser  Ser Asp Ile Asn Lys  Gly Val Leu 
    2375                 2380                 2385             


Ile Pro  Pro Arg Arg Lys Asn  Leu Phe Leu Asn Ile  Glu Lys Ser 
    2390                 2395                 2400             


Asp Ile  Cys Lys Tyr Lys Lys  Asn Pro Lys Leu Phe  Asn Asp Phe 
    2405                 2410                 2415             


Ile Tyr  Ser Ser Ala Phe Thr  Glu Val Glu Arg Leu  Lys Ile Val 
    2420                 2425                 2430             


Tyr Gly  Glu Ala Lys Thr Lys  Val Val His Ala Met  Lys Tyr Ser 
    2435                 2440                 2445             


Phe Ala  Asp Ile Gly Asn Ile  Ile Lys Gly Asp Asp  Met Met Glu 
    2450                 2455                 2460             


Asn Asn  Ser Ser Asp Lys Ile  Gly Lys Ile Leu Gly  Asp Thr Asp 
    2465                 2470                 2475             


Gly Gln  Asn Glu Lys Arg Lys  Ala Trp Trp Asp Met  Asn Lys Tyr 
    2480                 2485                 2490             


His Val  Trp Glu Ser Met Leu  Cys Gly Tyr Lys Gln  Ala Gly Gly 
    2495                 2500                 2505             


Asp Thr  Glu Thr Asn Glu Asn  Cys Arg Phe Pro Asp  Thr Asp Gly 
    2510                 2515                 2520             


Val Pro  Gln Phe Leu Arg Trp  Phe Gln Glu Trp Thr  Glu Thr Phe 
    2525                 2530                 2535             


Cys Val  Thr Arg Gln Glu Leu  Tyr Asp Glu Val Arg  Thr Lys Cys 
    2540                 2545                 2550             


Ala Thr  Ala Glu Cys Thr Asn  Gly Arg Ile Asn Glu  Ser Glu Cys 
    2555                 2560                 2565             


Thr Gln  Ala Cys Asp Lys Tyr  Lys Ser Tyr Val Leu  Ser Lys Lys 
    2570                 2575                 2580             


Thr Glu  Tyr Glu Ile Gln Lys  Lys Lys Tyr Asp Thr  Glu Phe Lys 
    2585                 2590                 2595             


Asn Gln  Asn Gly Ser Pro Lys  Asp Ala Ser Gln Tyr  Phe Lys Asp 
    2600                 2605                 2610             


Lys Cys  Asn Asp Asn Cys Asp  Cys Ile Ser Tyr His  Ile Asp Asp 
    2615                 2620                 2625             


Lys Glu  Asn Trp Lys Tyr Val  Tyr Asp Thr Tyr Asp  Asn Lys Asn 
    2630                 2635                 2640             


Leu Lys  Ala Ile Cys Asp Cys  Pro Lys Pro Leu Pro  Leu Phe Ser 
    2645                 2650                 2655             


Asp Asn  Thr Ser Asp Ile Leu  Gln Lys Thr Ile Pro  Phe Gly Ile 
    2660                 2665                 2670             


Ala Leu  Ala Leu Gly Ser Ile  Ala Phe Leu Phe Met  Lys Lys Lys 
    2675                 2680                 2685             


Pro Lys  Thr Pro Val Asp Leu  Leu Arg Val Leu Asp  Ile His Lys 
    2690                 2695                 2700             


Gly Asp  Tyr Gly Ile Pro Thr  Thr Lys Ser Ser Asn  Arg Tyr Ile 
    2705                 2710                 2715             


Pro Tyr  Val Ser Asp Thr Tyr  Lys Gly Lys Thr Tyr  Ile Tyr Met 
    2720                 2725                 2730             


Glu Gly  Glu Glu Thr Asp Asp  Tyr Ser Tyr Ile Arg  Asp Ile Ser 
    2735                 2740                 2745             


Ser Ser  Asp Ile Thr Ser Ser  Glu Ser Glu Tyr Glu  Glu Val Asp 
    2750                 2755                 2760             


Ile Asn  Asp Ile Tyr Val Pro  Ser Leu Pro Lys Tyr  Lys Thr Leu 
    2765                 2770                 2775             


Ile Glu  Val Val Leu Glu Pro  Ser Lys Arg Asp Thr  Phe Asn Thr 
    2780                 2785                 2790             


Ser Ser  Gly Asp Thr Phe Thr  Asn Lys Leu Thr Asp  Asp Glu Trp 
    2795                 2800                 2805             


Asn Gln  Leu Lys Gln Asp Phe  Ile Glu Gln Tyr Leu  Gln Asn Ile 
    2810                 2815                 2820             


Gln Lys  Asp Phe Ile Leu His  Asp Ser Met Asp Glu  Lys Pro Phe 
    2825                 2830                 2835             


Ile Thr  Gln Ile Gln Asp Arg  Phe Leu Asp Ser Ser  His Glu Glu 
    2840                 2845                 2850             


Val Thr  Tyr Asn Ile Asp Trp  Asn Val Pro Glu Asn  Ile Asn Arg 
    2855                 2860                 2865             


Ile Thr  Asn Asn Met Asp Asp  Pro Lys Tyr Ser Ser  Asn Asn Met 
    2870                 2875                 2880             


Tyr Thr  Gly Thr Asp Leu Ile  Asn Asp Ser Leu Asn  Gly Asn Gln 
    2885                 2890                 2895             


Tyr Ile  Asp Ile Tyr Asp Glu  Met Leu Lys Arg Lys  Glu Asn Glu 
    2900                 2905                 2910             


Leu Phe  Gly Thr Asn Asn Thr  Lys Asn Thr Thr Phe  Asn Ser Val 
    2915                 2920                 2925             


Ser Lys  Gln Thr Pro Ser Asp  Pro Ile Ile Asn Gln  Leu Asp Leu 
    2930                 2935                 2940             


Tyr His  Asn Trp Met Asp Lys  His Arg Asp Ile Cys  Glu Gln Trp 
    2945                 2950                 2955             


Lys Thr  Lys Glu Asp Met Leu  Tyr Lys Leu Asn Glu  Val Trp Asn 
    2960                 2965                 2970             


Met Glu  Arg Lys Glu Tyr Leu  Leu Asp Ile Gln Pro  Ser Thr Leu 
    2975                 2980                 2985             


Asp Asp  Ile His Lys Ile Asn  Asp Glu Thr Tyr Asn  Ile Ile Ser 
    2990                 2995                 3000             


Thr Asn  Asn Ile Tyr Asp His  Pro Ser Gln Glu Thr  Pro Leu Gln 
    3005                 3010                 3015             


Leu Leu  Gly Ser Thr Asn Ile  Ile Pro Ser Tyr Ile  Thr Thr Glu 
    3020                 3025                 3030             


Gln Asn  Asn Gly Leu Arg Thr  Asn Ile Ser Met Asp  Thr Tyr Ile 
    3035                 3040                 3045             


Asp Glu  Thr Asn Asn Asn Asn  Val Val Ala Thr Ser  Ile Ile Gly 
    3050                 3055                 3060             


Asp Asp  Gln Met Glu Asn Ser  Tyr Asn Cys 
    3065                 3070             


<210>  58
<211>  3283
<212>  PRT
<213>  Plasmodium falciparum

<400>  58

Met Asp Lys Ser Ser Ile Gly Asp Lys Ile Glu Ala Tyr Leu Glu Lys 
1               5                   10                  15      


Lys Ser Asp Glu Ser Asp Ile Glu Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Arg Lys 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr Glu 
    50                  55                  60                  


Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Ile Asp Glu Trp Lys 
65                  70                  75                  80  


Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Lys Pro Glu Asn Ile Cys 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Asn Leu 
            100                 105                 110         


Lys Phe Asp Lys Ile Arg Asp Asn Asn Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn Lys 
                165                 170                 175     


Phe Glu Pro Cys Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn Asp 
            180                 185                 190         


Lys Val Leu Gln Asp Lys Tyr Pro Asn Asp Asp Pro Lys Tyr Thr Lys 
        195                 200                 205             


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
    210                 215                 220                 


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Leu Gly Trp 
225                 230                 235                 240 


Thr Ser Ser Lys Glu Ser Glu Gly Asp Asn Lys Leu Glu Leu Cys Arg 
                245                 250                 255     


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
            260                 265                 270         


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
        275                 280                 285             


Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His Arg Glu Glu Cys 
    290                 295                 300                 


Thr Arg Lys Asn Val Glu Ser Lys Glu Gly Thr Ser Tyr Cys Thr Asn 
305                 310                 315                 320 


Cys Lys Glu Lys Cys Lys Lys Tyr Cys Glu Tyr Val Asn Lys Trp Lys 
                325                 330                 335     


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Asn Asp Leu Tyr Gln Gln 
            340                 345                 350         


Glu Asn Lys Thr Ser Ser Ser Ser Lys Lys Lys Ser Arg Tyr Asp Asp 
        355                 360                 365             


Tyr Val Lys Glu Phe Phe Lys Asn Phe Lys Gly Asp Asn Tyr Lys Ser 
    370                 375                 380                 


Leu Glu Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr 
385                 390                 395                 400 


Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Thr Glu Asn Ala Ser Glu 
                405                 410                 415     


Thr Pro Ser Lys Tyr Tyr Asp Glu Ala Cys Asn Cys Asn Glu Ser Glu 
            420                 425                 430         


Ile Ala Ser Val Gly Gln Ala Gln Thr Ser Gly Pro Ser Ser Asn Lys 
        435                 440                 445             


Thr Cys Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Glu Cys 
    450                 455                 460                 


Lys Asp Val Lys Leu Gly Ile Asn Asn Asn Asp Lys Val Leu Arg Val 
465                 470                 475                 480 


Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys 
                485                 490                 495     


Gln Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asp Lys Asn Ser Glu Glu Ile Cys 
        515                 520                 525             


Gln Lys Lys Leu Glu Lys Val Phe Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Cys Asp Lys Cys Lys Ser Gly Thr Ser Arg Ser Lys Lys Lys Trp Ile 
545                 550                 555                 560 


Trp Lys Lys Ser Ser Gly Asn Glu Glu Gly Leu Gln Lys Glu Tyr Ala 
                565                 570                 575     


Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Cys 
            580                 585                 590         


Leu His Glu Lys Glu Gly Lys Thr Gln His Lys Thr Ile Ser Thr Asn 
        595                 600                 605             


Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly Lys 
    610                 615                 620                 


Asn Leu Lys Thr Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys Lys 
625                 630                 635                 640 


Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile 
                645                 650                 655     


Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu Leu 
            660                 665                 670         


Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys Lys 
        675                 680                 685             


Asn Asn Thr Ala Glu Gln His Thr Ser Tyr Ser Ser Leu Asp Glu Leu 
    690                 695                 700                 


Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Thr Ala Met 
705                 710                 715                 720 


Lys His Gly Ala Gly Met Asn Gly Thr Thr Cys Ser Cys Ser Gly Asp 
                725                 730                 735     


Ser Ser Asn Asp Met Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg 
            740                 745                 750         


Phe Leu Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg Gln Glu Lys 
        755                 760                 765             


Val Asn Ala Val Ile Glu Asn Cys Asn Ser Cys Lys Glu Ser Gly Gly 
    770                 775                 780                 


Thr Cys Asn Ser Asp Cys Lys Thr Glu Cys Lys Asn Lys Cys Glu Ala 
785                 790                 795                 800 


Tyr Lys Glu Phe Ile Glu Asp Cys Lys Gly Gly Gly Thr Gly Thr Ala 
                805                 810                 815     


Gly Ser Pro Trp Ser Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser 
            820                 825                 830         


Lys His Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn 
        835                 840                 845             


Cys Gly Thr Ser Ser Thr Thr Asn Ala Ala Ala Ser Thr Asp Glu Asn 
    850                 855                 860                 


Lys Cys Val Gln Ser Asp Val Asp Ser Phe Phe Lys His Leu Ile Asp 
865                 870                 875                 880 


Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Asn Val Leu Asp Asp 
                885                 890                 895     


Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr 
            900                 905                 910         


Thr Thr Thr Lys Asn Cys Asp Ile Gln Lys Lys Thr Pro Lys Ser Gln 
        915                 920                 925             


Ser Cys Asp Thr Leu Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
    930                 935                 940                 


Thr Pro His Glu Tyr Lys Tyr Ala Cys Glu Cys Lys Ile Pro Thr Thr 
945                 950                 955                 960 


Glu Glu Thr Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp Ser Cys 
                965                 970                 975     


Gly Ser Ala Gln Thr Val Arg Gly Arg Ser Gly Lys Asp Asp Tyr Glu 
            980                 985                 990         


Leu Tyr Thr Tyr Asn Gly Val Lys  Glu Thr Lys Pro Leu  Gly Thr Leu 
        995                 1000                 1005             


Lys Asn  Ser Lys Leu Asp Gly  Asn Asp Val Met Phe  Phe Asn Leu 
    1010                 1015                 1020             


Phe Glu  Gln Trp Asn Lys Glu  Ile Gln Tyr Gln Ile  Glu Gln Tyr 
    1025                 1030                 1035             


Met Thr  Asn Thr Lys Ile Ser  Cys Asn Asn Glu Met  Lys Ile Leu 
    1040                 1045                 1050             


Ser Ser  Ser Ser Glu Glu Ser  Gln Asn Gln Asn Gly  Ser Asp His 
    1055                 1060                 1065             


His Asp  Gly Arg Asn Asn Asn  Ile Asn Gln Gly Thr  Asn Cys Lys 
    1070                 1075                 1080             


Lys Asn  Cys Glu Cys Tyr Ser  Leu Trp Ile Glu Lys  Ile Lys Lys 
    1085                 1090                 1095             


Gln Trp  Asp Lys Gln Lys Asp  Asn Tyr Asn Lys Phe  Gln Arg Lys 
    1100                 1105                 1110             


Gln Ile  Tyr Asp Ala Asn Lys  Gly Pro Gln Asn Lys  Lys Val Val 
    1115                 1120                 1125             


Ser Leu  Ser His Phe Leu Phe  Phe Ser Cys Trp Glu  Glu Tyr Ile 
    1130                 1135                 1140             


Gln Lys  Tyr Phe Asn Gly Asp  Trp Ser Lys Ile Lys  Asn Ile Gly 
    1145                 1150                 1155             


Ser Asp  Thr Phe Glu Phe Leu  Ile Lys Lys Cys Gly  Asn Asp Ser 
    1160                 1165                 1170             


Gly Asp  Gly Glu Thr Ile Phe  Asn Lys Lys Leu Asn  Asn Ala Asn 
    1175                 1180                 1185             


Ile Lys  Cys Asn Glu Asn Ala  Ser Lys Asp Thr Lys  Ile Asn Lys 
    1190                 1195                 1200             


Ser Glu  Thr Ser Ser Lys Cys  Ser Glu Pro Ile Tyr  Ile Arg Gly 
    1205                 1210                 1215             


Cys Gln  Ser Lys Arg Tyr Asp  Gly Phe Ile Ser Pro  Gly Lys Gly 
    1220                 1225                 1230             


Gly Glu  Lys Gln Trp Ile Cys  Lys Asp Thr Ile Ile  His Gly Asp 
    1235                 1240                 1245             


Thr Asn  Gly Ala Cys Ile Pro  Pro Arg Thr Gln Asn  Leu Cys Val 
    1250                 1255                 1260             


Gly Glu  Leu Trp Asp Lys Arg  Tyr Gly Gly Arg Ser  Asn Ile Lys 
    1265                 1270                 1275             


Asn Asp  Thr Lys Glu Ser Leu  Lys Asn Lys Leu Lys  Asn Ala Ile 
    1280                 1285                 1290             


Gln Lys  Glu Thr Glu Leu Leu  Tyr Glu Tyr His Asp  Thr Gly Thr 
    1295                 1300                 1305             


Ala Ile  Ile Ser Arg Asn Pro  Met Lys Glu Gly Gly  Glu Asp Gly 
    1310                 1315                 1320             


Lys Gly  Lys Gln Lys Glu Gly  Gly Glu Glu Ala Asn  Asn Asn Phe 
    1325                 1330                 1335             


Asn Gly  Leu Pro Lys Gly Phe  Cys His Ala Val Gln  Arg Ser Phe 
    1340                 1345                 1350             


Ile Asp  Tyr Lys Asn Met Ile  Leu Gly Thr Ser Val  Ser Thr Tyr 
    1355                 1360                 1365             


Glu Tyr  Ile Gly Lys Leu Gln  Glu Asp Ile Lys Lys  Ile Ile Glu 
    1370                 1375                 1380             


Gln Gly  Arg Lys Pro Lys Asp  Lys Thr Val Gly Ser  Gly Ala Asp 
    1385                 1390                 1395             


Lys Val  Asn Asp Trp Trp Lys  Glu Ile Glu Lys Asp  Met Trp Gly 
    1400                 1405                 1410             


Ala Val  Lys Cys Gly Ile Lys  Thr Ile Lys Lys Gln  Lys Lys Asn 
    1415                 1420                 1425             


Gly Thr  Phe Asn Gly Asp Glu  Cys Gly Val Ser Pro  Pro Thr Gly 
    1430                 1435                 1440             


Asn Asp  Glu Asp Gln Phe Val  Ser Trp Phe Lys Glu  Trp Gly Glu 
    1445                 1450                 1455             


Gln Phe  Cys Ile Glu Arg Leu  Arg Tyr Glu Gln Asn  Ile Arg Asp 
    1460                 1465                 1470             


Ala Cys  Ile Asn Lys Asp Met  Glu Gln Asn Lys Cys  Ile Asn Ser 
    1475                 1480                 1485             


Lys Asn  Asn Asn Glu Lys Glu  Ile Gln Gly Asp Cys  Lys Arg Lys 
    1490                 1495                 1500             


Cys Glu  Lys Tyr Lys Lys Tyr  Ile Ser Glu Lys Lys  Gln Glu Trp 
    1505                 1510                 1515             


Asp Lys  Gln Lys Thr Lys Tyr  Glu Asn Lys Tyr Val  Gly Lys Ser 
    1520                 1525                 1530             


Ala Ser  Asp Leu Leu Lys Glu  Asn Tyr Pro Glu Cys  Ile Ser Ala 
    1535                 1540                 1545             


Asn Phe  Asp Phe Ile Phe Asn  Asp Asn Ile Glu Tyr  Lys Thr Tyr 
    1550                 1555                 1560             


Tyr Pro  Tyr Gly Asp Tyr Ser  Ser Ile Cys Ser Cys  Glu Gln Val 
    1565                 1570                 1575             


Lys Tyr  Tyr Lys Tyr Ile Lys  Asp Lys Gly Gln Asn  Asn Lys Ser 
    1580                 1585                 1590             


Leu Cys  His Glu Lys Gly Asn  Asp Arg Thr Trp Ser  Lys Lys Tyr 
    1595                 1600                 1605             


Ile Lys  Lys Leu Glu Asn Gly  Arg Thr Leu Glu Gly  Val Tyr Val 
    1610                 1615                 1620             


Pro Pro  Arg Arg Gln Gln Leu  Cys Leu Tyr Glu Leu  Phe Pro Ile 
    1625                 1630                 1635             


Ile Ile  Lys Lys Glu Lys Asp  Met Glu Lys Ala Lys  Glu Glu Leu 
    1640                 1645                 1650             


Leu Glu  Thr Leu Gln Ile Val  Ala Glu Arg Glu Ala  Tyr Tyr Leu 
    1655                 1660                 1665             


Trp Lys  Gln Tyr His Ala His  Asn Asp Thr Thr Tyr  Leu Ala His 
    1670                 1675                 1680             


Lys Lys  Ala Cys Cys Ala Ile  Arg Gly Ser Phe Tyr  Asp Leu Glu 
    1685                 1690                 1695             


Asp Ile  Ile Lys Gly Asn Asp  Leu Val His Asp Glu  Tyr Thr Lys 
    1700                 1705                 1710             


Tyr Ile  Asp Ser Lys Leu Asn  Glu Ile Phe Gly Ser  Ser Asn Lys 
    1715                 1720                 1725             


Asn Asp  Ile Glu Thr Lys Arg  Ala Arg Thr Asp Trp  Trp Glu Asn 
    1730                 1735                 1740             


Glu Thr  Ile Asp Val Ala Asn  Gly Thr Asp Arg Lys  Thr Ile Arg 
    1745                 1750                 1755             


Gln Leu  Val Trp Asp Ala Met  Gln Ser Gly Val Arg  Lys Ala Ile 
    1760                 1765                 1770             


Asp Glu  Glu Lys Glu Lys Lys  Lys Pro Asn Lys Asn  Phe Pro Pro 
    1775                 1780                 1785             


Cys Met  Gly Val Glu His Ile  Gly Ile Ala Lys Pro  Gln Phe Ile 
    1790                 1795                 1800             


Arg Trp  Leu Glu Glu Trp Thr  Asn Glu Phe Cys Glu  Glu Tyr Thr 
    1805                 1810                 1815             


Lys Tyr  Phe Gly Ala Ile Asn  Ser Asn Cys Asn Leu  Arg Lys Gly 
    1820                 1825                 1830             


Ala Asp  Asp Cys Gly Asp Asn  Ser Asn Ile Glu Cys  Lys Arg Ala 
    1835                 1840                 1845             


Cys Ala  Asn Tyr Thr Asn Trp  Leu Asn Pro Lys Arg  Ile Glu Trp 
    1850                 1855                 1860             


Asn Gly  Met Ser Asn Tyr Tyr  Asn Lys Ile Tyr Arg  Lys Ser Asn 
    1865                 1870                 1875             


Lys Glu  Ser Glu Asp Gly Lys  Asp Tyr Ser Met Ile  Met Glu Pro 
    1880                 1885                 1890             


Thr Val  Ile Asp Tyr Leu Asn  Lys Arg Cys Asn Gly  Glu Ile Asn 
    1895                 1900                 1905             


Gly Asn  Tyr Ile Cys Cys Ser  Cys Lys Asn Ile Gly  Glu Asn Ser 
    1910                 1915                 1920             


Thr Ser  Pro Val Ala Asn Lys  Lys Ala Gln Arg Lys  Glu Thr Glu 
    1925                 1930                 1935             


Cys Glu  Glu Glu Lys Gly Pro  Leu Asp Leu Met Asn  Glu Val Leu 
    1940                 1945                 1950             


Asn Lys  Met Asp Glu Lys Tyr  Ser Ala His Lys Met  Lys Cys Thr 
    1955                 1960                 1965             


Glu Val  Tyr Leu Glu His Val  Glu Glu Gln Leu Lys  Glu Ile Asp 
    1970                 1975                 1980             


Asn Ala  Ile Lys Asp Tyr Gln  Leu Tyr Pro Leu Asp  Arg Cys Phe 
    1985                 1990                 1995             


Asp Asp  Gln Thr Lys Met Lys  Ile Cys Asp Leu Ile  Gly Asp Ala 
    2000                 2005                 2010             


Ile Gly  Cys Lys His Lys Ile  Asn Leu Asp Glu Leu  Asp Glu Trp 
    2015                 2020                 2025             


Asn Asp  Met Asp Met Arg Asp  Pro Tyr Asn Lys Tyr  Lys Gly Val 
    2030                 2035                 2040             


Leu Ile  Pro Pro Arg Arg Arg  Gln Leu Cys Phe Ser  Arg Ile Val 
    2045                 2050                 2055             


Arg Gly  Pro Ala Asn Leu Arg  Ser Leu Asn Glu Phe  Lys Glu Glu 
    2060                 2065                 2070             


Ile Leu  Lys Gly Ala Gln Ser  Glu Gly Lys Phe Leu  Gly Asn Tyr 
    2075                 2080                 2085             


Tyr Lys  Glu His Lys Asp Lys  Glu Lys Ala Leu Glu  Ala Met Lys 
    2090                 2095                 2100             


Asn Ser  Phe Tyr Asp Tyr Glu  Tyr Ile Ile Lys Gly  Ser Asp Ile 
    2105                 2110                 2115             


Leu Glu  Asn Ile Glu Phe Lys  Asp Ile Lys Arg Lys  Leu Asp Lys 
    2120                 2125                 2130             


Leu Leu  Thr Lys Glu Thr Asn  Asn Asn Thr Lys Lys  Ala Glu Asp 
    2135                 2140                 2145             


Trp Trp  Glu Thr Asn Lys Lys  Ser Ile Trp Asn Ala  Ile Leu Cys 
    2150                 2155                 2160             


Gly Tyr  Lys Lys Ser Gly Asn  Lys Ile Ile Asp Pro  Ser Trp Cys 
    2165                 2170                 2175             


Lys Ile  Pro Thr Thr Glu Thr  Pro Pro Gln Phe Leu  Arg Trp Ile 
    2180                 2185                 2190             


Lys Glu  Trp Gly Thr Tyr Phe  Cys Glu Glu Lys Glu  Lys Gln Lys 
    2195                 2200                 2205             


Asn Ile  Val Asn Ile Lys Cys  Thr Asp Ser Asp His  Ile Ile Gly 
    2210                 2215                 2220             


Lys Ser  Ile Lys Ala Ser Glu  Lys Leu Glu Cys Lys  Leu Ala Thr 
    2225                 2230                 2235             


Gly Asn  Tyr Glu Gln Trp Asn  Thr Asn Arg Leu Lys  Glu Trp Lys 
    2240                 2245                 2250             


Leu Leu  Ser Gln Gln Tyr Lys  Thr Asn Lys Glu Ser  Asn Lys Asp 
    2255                 2260                 2265             


Ile Asp  Met Ser Glu Leu Ser  Ala Glu Gln Tyr Leu  Lys Lys His 
    2270                 2275                 2280             


Cys Thr  Gly Cys Ser Cys Arg  Phe Ser Asp Met Asp  Glu Leu Tyr 
    2285                 2290                 2295             


Ile Lys  Thr Leu Lys Asn Glu  Asn Leu His Glu Glu  Ile Leu Lys 
    2300                 2305                 2310             


Asn Ala  Gln Ile Pro Ile Tyr  Phe Glu Glu Val Tyr  His Arg Phe 
    2315                 2320                 2325             


Asp Arg  Ser Asp Val Gln Cys  Pro Asp Asn Asn Ile  Cys Asn Leu 
    2330                 2335                 2340             


Tyr Lys  Ser Ile Pro Cys Lys  Glu Met Leu Asn Asp  Glu Glu Val 
    2345                 2350                 2355             


Thr Ala  Trp Thr Thr His Ser  Val Thr Asp Ala Ser  Lys Ala Ile 
    2360                 2365                 2370             


Lys Ile  Val Leu Ile Pro Pro  Arg Arg Arg Asn Leu  Cys Leu Val 
    2375                 2380                 2385             


Ile Asn  Glu Thr Gln Met Lys  Glu Phe Lys Thr Asn  Lys Glu Met 
    2390                 2395                 2400             


Phe Lys  Ser Phe Ile Tyr Ser  Ser Ala Ala Ser Glu  Val Thr Arg 
    2405                 2410                 2415             


Leu Lys  Lys Val His Asn Asp  Asn Lys Asp Lys Val  Leu Gln Ala 
    2420                 2425                 2430             


Met Lys  Tyr Ser Phe Ser Asp  Ile Gly Asn Ile Ile  Lys Gly Asp 
    2435                 2440                 2445             


Asp Met  Met Lys Cys Ser Ile  Ser Asp Asn Ile Ser  Glu Ile Leu 
    2450                 2455                 2460             


Asp Glu  Lys Asn Gly Ser Thr  Lys Lys Arg Ile Ile  Trp Trp Ser 
    2465                 2470                 2475             


Gln Asn  Lys Tyr His Ile Trp  Glu Ala Met Leu Cys  Ala Tyr Gln 
    2480                 2485                 2490             


Lys Asp  Asn Lys Lys Ile Glu  Phe Thr Ser His Asp  Cys Lys Met 
    2495                 2500                 2505             


Pro Asp  Thr Glu Lys Thr Pro  Gln Phe Leu Arg Trp  Leu Ile Glu 
    2510                 2515                 2520             


Trp Ser  Lys Gln Val Cys Ala  His Lys Leu Ser Lys  Ala Lys Tyr 
    2525                 2530                 2535             


Val Lys  Glu Asn Cys Ser Asn  Tyr Ile Lys Asp Lys  Glu Ser Asp 
    2540                 2545                 2550             


Lys Glu  Gln Cys Ile Asn Ala  Ser Asn Ile Tyr Ile  Gln Trp Met 
    2555                 2560                 2565             


Asn Lys  Gln Lys Glu Pro Trp  Lys Ile Leu Ser Asn  Ile Tyr Thr 
    2570                 2575                 2580             


Asn Tyr  Lys Asn Glu Lys Asn  Met Asn Tyr Pro Asn  Leu Pro Arg 
    2585                 2590                 2595             


Asn Ala  Ser Tyr Tyr Val Arg  Glu Lys Cys Pro Glu  Cys Ile Cys 
    2600                 2605                 2610             


Asn Leu  Glu His Leu Glu Glu  Lys Glu Asn Gln Asn  His Gln Asn 
    2615                 2620                 2625             


Gly Asp  His Leu Ile Glu Glu  Ala Ile Asn Lys Ala  Lys Met Asp 
    2630                 2635                 2640             


Leu Pro  Asp Thr Glu Trp Gly  Ile Ser Trp Gly Pro  Trp Lys Val 
    2645                 2650                 2655             


Asn Trp  Glu Asn Met Phe Phe  Ile Ser Ser Phe Phe  Pro Arg Ile 
    2660                 2665                 2670             


Lys Ile  Val Ser Arg Asp Thr  Ala Ile Thr Asn Asp  Ile Ser Asn 
    2675                 2680                 2685             


Val Ser  His Ser Lys Asp Pro  Val Ala Lys Asp Arg  Ser Ile Asn 
    2690                 2695                 2700             


Asp Ala  Met Val Asp Val Val  Asn Ile Val Thr Gln  Pro Val Thr 
    2705                 2710                 2715             


Thr Val  Ile Asp Asn Val Thr  Pro Thr Leu Gly Arg  Glu Leu Asn 
    2720                 2725                 2730             


Lys Val  Val Asn Pro Ile Asn  Asn Ile Leu Asn Glu  Val Thr Thr 
    2735                 2740                 2745             


Ser Val  Gln Ser Ser Val Thr  Lys Val Lys Glu Thr  Gly Asn Lys 
    2750                 2755                 2760             


Ile Thr  Glu Asp Ile Lys Lys  Ile Ile Asp Asn Met  Gly Asn Ile 
    2765                 2770                 2775             


Met Glu  Gly Ile Ile Gln Ser  Leu Glu Lys Thr Lys  Glu Lys Glu 
    2780                 2785                 2790             


His Lys  Glu Phe Lys Ser Lys  Gln Ile Leu Asp Ser  Lys Glu Asn 
    2795                 2800                 2805             


Thr Tyr  Pro Asn Thr Ile Val  Pro Thr Asn Met Glu  Asp Val Leu 
    2810                 2815                 2820             


Thr Met  Tyr His Lys Ile Asp  Ile Ile Ala Pro Ala  Ile Ser Val 
    2825                 2830                 2835             


Gly Ile  Ile Thr Leu Gly Tyr  Ala Leu Tyr Lys Ser  Gly Leu Phe 
    2840                 2845                 2850             


Gly Phe  Ile Gly Ser Lys Arg  Lys Gly Glu Asp Val  Ile Glu Arg 
    2855                 2860                 2865             


Ile Arg  Leu Leu Lys Phe Ala  Glu Asn Lys Leu Gly  Ser Ser Thr 
    2870                 2875                 2880             


Ser Thr  Tyr Thr Tyr Lys Lys  Tyr Ser Gly Glu Pro  Val Gln Glu 
    2885                 2890                 2895             


Tyr Met  Glu Met Gly Ser Tyr  Lys Gly Gln Thr Tyr  Ile Tyr Ile 
    2900                 2905                 2910             


Glu Gly  Asp Asp Thr Asp Glu  Asp Tyr Ile Glu Asn  Ile Ser Ser 
    2915                 2920                 2925             


Thr Asp  Ala Ser Ser Glu Ser  Glu Tyr Asp Glu Leu  Asp Val Ser 
    2930                 2935                 2940             


His Ile  Tyr Pro Tyr Arg Lys  Pro Lys Tyr Lys Thr  Leu Ile Glu 
    2945                 2950                 2955             


Leu Ile  Leu Glu Pro Asn Asn  Lys Asn Glu Asp Thr  Tyr Asp Thr 
    2960                 2965                 2970             


Pro Ser  Tyr Gln Lys Asp Asp  Asn Asp Lys Pro Thr  Asp Asp Glu 
    2975                 2980                 2985             


Trp Asn  Gln Leu Lys Asn Asp  Phe Ile Leu Gln Phe  Leu Val Asp 
    2990                 2995                 3000             


Glu Glu  Pro Lys Asp Leu Asn  Asn His Leu Pro Asp  Lys Pro Ser 
    3005                 3010                 3015             


Thr Asp  Asn Pro Ser Asp Glu  Ile Phe Met Asp Asp  Glu Lys Pro 
    3020                 3025                 3030             


Phe Ile  Ile Ser Ile Gln Asp  Arg Ser Leu Asn Asn  Gly Glu Ser 
    3035                 3040                 3045             


Val Thr  Tyr Tyr Met Asn Gly  Asn Ala Gln Ser Asn  Met Asp Ile 
    3050                 3055                 3060             


Ser Thr  Asn Asn Glu Tyr Val  Thr Lys Ile Thr Gln  Asn Arg Ser 
    3065                 3070                 3075             


Tyr Ser  Gly Met Asp Leu Ile  Asn Cys Ser Leu Thr  Arg Lys Ser 
    3080                 3085                 3090             


Asn Val  Asn Ile Tyr Gly Glu  Leu Leu Lys Arg Lys  Glu Lys Glu 
    3095                 3100                 3105             


Leu His  Ala Met Glu Tyr Asn  Pro Ile Trp Leu Leu  Pro Lys Phe 
    3110                 3115                 3120             


Glu Pro  Leu Ser Thr Gln Gly  Gln Asn Asn Phe Gln  Phe Ile Asn 
    3125                 3130                 3135             


Ile Asn  Phe Ile Asp Lys Trp  Leu Asn Gln Asn Arg  Glu Ile Ile 
    3140                 3145                 3150             


Asn Lys  Leu Asn Lys Gly Asp  Arg Leu Glu Tyr Leu  Lys Asp Leu 
    3155                 3160                 3165             


Trp Met  Lys Glu His Asn Met  Asn Ser Ile Thr His  Leu Asp Ser 
    3170                 3175                 3180             


Thr Thr  Thr Phe Ile Asn Gly  Asn Thr Leu Arg Arg  Asn Ile Ser 
    3185                 3190                 3195             


Met Asp  Gln Asn Ser Leu Ser  Glu Asn Asn Asp Pro  Met Asp Leu 
    3200                 3205                 3210             


Asn Asn  Asn Asn Pro Leu Asn  Phe Ile Asp Tyr Leu  Glu Gln Ser 
    3215                 3220                 3225             


Ile Asn  Glu Arg Asn Asp Ile  Phe Asp Asp Val Ile  Phe Tyr Asp 
    3230                 3235                 3240             


Thr Met  Glu Glu Ser Gln Lys  Asp Ile Pro Tyr Ser  Lys Asp Tyr 
    3245                 3250                 3255             


Thr Asn  Ser His Lys Val Lys  Ala Pro Ile Asn Leu  His Ser Gly 
    3260                 3265                 3270             


Asn Lys  Ser Glu Asn Gly Thr  Leu Pro Val 
    3275                 3280             


<210>  59
<211>  3091
<212>  PRT
<213>  Plasmodium falciparum

<400>  59

Met Asp Lys Ser Ser Ile Gly Asp Lys Ile Glu Glu Tyr Leu Lys Glu 
1               5                   10                  15      


Lys Ser Asn Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Arg Ser Gly Gly Asp Gly Tyr Tyr Leu Lys Asn 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Asp Glu Asn Leu Tyr Lys Ala Ser Glu Asn Asn Lys Asn Ile Phe 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Lys Leu 
            100                 105                 110         


Asn Val Glu Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Leu Ala Asp Ile Ile Arg Gly Arg Asp Gly Asn Lys Cys Glu Thr Lys 
                165                 170                 175     


Ser Thr Asn Asn Val Glu Glu Leu Ile Lys Lys Phe Phe Glu Lys Asn 
            180                 185                 190         


Tyr Arg Glu Asn Lys Glu Tyr Lys Arg Lys Tyr Arg Asn Asp Asp Pro 
        195                 200                 205             


Lys Tyr Thr Lys Leu Arg Glu Asp Trp Trp Thr Lys Asn Arg Gln Lys 
    210                 215                 220                 


Val Trp Glu Val Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile 
225                 230                 235                 240 


Lys Arg Arg Trp Arg Thr Ser Gly Lys Ser Asn Gly Glu Asn Lys Leu 
                245                 250                 255     


Glu Leu Cys Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Lys 
            260                 265                 270         


Leu Asp Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu 
        275                 280                 285             


Asp Leu Tyr Arg Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His 
    290                 295                 300                 


Arg Glu Glu Cys Thr Ser Glu Asp Asp Lys Ser Lys Glu Val Thr Ser 
305                 310                 315                 320 


Tyr Cys Asn Met Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Tyr Val 
                325                 330                 335     


Asn Lys Trp Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu 
            340                 345                 350         


Leu Tyr Glu Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Ala Ser Arg 
        355                 360                 365             


Tyr Asp Asp Tyr Val Lys Asp Phe Phe Lys Lys Leu Asn Glu Ala Asn 
    370                 375                 380                 


Tyr Lys Ser Leu Asp Asp Tyr Ile Lys Asp Asp Pro Tyr Ser Lys Glu 
385                 390                 395                 400 


Tyr Val Thr Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Thr 
                405                 410                 415     


Ser Ser Gly Glu Thr Ala Asn His Asn Asp Glu Ala Cys Asn Pro Asn 
            420                 425                 430         


Glu Ser Glu Ile Ser Ser Val Gly Gln Ala Pro Ile Ser Asp Pro Ser 
        435                 440                 445             


Ser Asn Lys Thr Cys Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys 
    450                 455                 460                 


Lys Glu Cys Lys His Val Lys Leu Gly Val Arg Glu Asn Asp Lys Val 
465                 470                 475                 480 


Leu Arg Val Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn 
                485                 490                 495     


Cys Cys Cys Gln Asp Leu Leu Gly Met Leu Gln Glu Pro Arg Ile Asp 
            500                 505                 510         


Lys Asn Gln Arg Gly Ser Ser Ser Asn Gly Ser Cys Asp Lys Asn Ser 
        515                 520                 525             


Glu Glu Ile Cys Gln Lys Lys Leu Asp Glu Ala Leu Ala Ser Leu Thr 
    530                 535                 540                 


Asn Gly Tyr Lys Cys Asp Lys Cys Lys Ser Gly Thr Ser Thr Val Asn 
545                 550                 555                 560 


Lys Asn Trp Ile Trp Lys Lys Tyr Ser Gly Lys Glu Gly Gly Leu Gln 
                565                 570                 575     


Glu Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu 
            580                 585                 590         


Cys Leu Val Cys Leu His Glu Lys Glu Gly Lys Thr Gln His Lys Thr 
        595                 600                 605             


Ile Ser Thr Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Asp Ala Phe 
    610                 615                 620                 


His Glu Gly Lys Asn Leu Lys Thr Ser His Gln Asn Lys Asn Ser Gly 
625                 630                 635                 640 


Asn Lys Glu Asn Leu Cys Lys Asp Leu Lys Tyr Ser Phe Ala Asp Tyr 
                645                 650                 655     


Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys 
            660                 665                 670         


Asp Leu Glu Leu Asn Leu Gln Lys Ala Phe Gly Lys Leu Phe Arg Lys 
        675                 680                 685             


Tyr Ile Lys Lys Asn Asn Thr Ala Glu Gln His Thr Ser Tyr Ser Ser 
    690                 695                 700                 


Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile 
705                 710                 715                 720 


Trp Leu Ala Met Lys His Gly Ala Gly Met Asn Gly Thr Thr Cys Cys 
                725                 730                 735     


Gly Asp Gly Ser Val Thr Gly Ser Ser Asp Ser Gly Ser Thr Thr Cys 
            740                 745                 750         


Ser Gly Asp Asn Gly Ser Ile Ser Cys Asp Asp Ile Pro Thr Ile Asp 
        755                 760                 765             


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
    770                 775                 780                 


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Thr Asn Cys Asn 
785                 790                 795                 800 


Ser Cys Lys Asn Thr Ser Ser Lys Thr Lys Leu Gly Gly Thr Cys Asn 
                805                 810                 815     


Ser Asp Cys Glu Lys Lys Cys Lys Asp Glu Cys Glu Lys Tyr Lys Lys 
            820                 825                 830         


Phe Ile Glu Glu Phe Cys Thr Ala Ala Gly Gly Thr Ser Gly Ser Pro 
        835                 840                 845             


Trp Ser Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile 
    850                 855                 860                 


Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly Pro 
865                 870                 875                 880 


Ser Ser Thr Thr Ser Thr Ala Glu Asn Lys Cys Val Gln Ser Asp Ile 
                885                 890                 895     


Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser 
            900                 905                 910         


Ser Tyr Leu Ser Ile Val Leu Asp Glu Asn Asn Cys Gly Glu Asp Asn 
        915                 920                 925             


Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Lys Asn Cys Asp 
    930                 935                 940                 


Ile Gln Lys Lys Thr Pro Lys Ser Gln Ser Cys Asn Thr Ala Val Val 
945                 950                 955                 960 


Val Asn Val Pro Ser Pro Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr 
                965                 970                 975     


Ala Cys Gln Cys Lys Ile Pro Thr Thr Glu Glu Ser Cys Asp Asp Arg 
            980                 985                 990         


Lys Glu Tyr Met Asn Gln Trp Ser  Ser Gly Ser Ala Gln  Thr Val Arg 
        995                 1000                 1005             


Gly Arg  Ser Thr Asn Asn Asp  Tyr Glu Leu Tyr Thr  Tyr Asn Gly 
    1010                 1015                 1020             


Val Lys  Glu Thr Lys Leu Pro  Lys Lys Leu Asn Ser  Ser Lys Leu 
    1025                 1030                 1035             


Asp Gly  Asn Asp Val Met Phe  Phe Asn Leu Phe Glu  Gln Trp Asn 
    1040                 1045                 1050             


Lys Glu  Ile Gln Tyr Gln Ile  Glu Gln Tyr Met Thr  Asn Ala Asn 
    1055                 1060                 1065             


Ile Ser  Cys Asn Asn Glu Met  Asn Val Leu Ser Ser  Ser Ser Glu 
    1070                 1075                 1080             


Glu Ser  Lys Asn Gln Asn Gly  Ser Asp His Pro Asp  Gly Arg Asn 
    1085                 1090                 1095             


Asn Asn  Ile Asn Gln Gly Thr  Asn Cys Lys Glu Lys  Cys Lys Cys 
    1100                 1105                 1110             


Tyr Glu  Leu Trp Ile Lys Lys  Ile Lys Glu Gln Trp  Gly Lys Gln 
    1115                 1120                 1125             


Lys Asp  Asn Tyr Asn Lys Phe  Glu Lys Lys Thr Ser  Asn Asp Ala 
    1130                 1135                 1140             


Arg Lys  Ser Ser Gln Asn Lys  Lys Val Val Ser Leu  Ser His Phe 
    1145                 1150                 1155             


Leu Phe  Phe Ser Cys Trp Glu  Glu Tyr Ile Gln Lys  Tyr Phe Asn 
    1160                 1165                 1170             


Gly Asp  Trp Ser Lys Ile Lys  Asn Ile Gly Ser Asp  Thr Phe Asp 
    1175                 1180                 1185             


Phe Leu  Ile Lys Lys Cys Gly  Asn Asp Ser Ala His  Gly Glu Thr 
    1190                 1195                 1200             


Ile Phe  Asn Lys Lys Leu Asn  Asn Ala Asn Ile Lys  Cys Asn Glu 
    1205                 1210                 1215             


Asn Glu  Ser Thr Asn Asn Lys  Met Lys Ser Ser Glu  Thr Ser Cys 
    1220                 1225                 1230             


Asp Cys  Ser Glu Pro Ile Tyr  Ile Arg Gly Cys Gln  Ser Lys Thr 
    1235                 1240                 1245             


Tyr Asp  Gly Lys Ile Phe Pro  Gly Lys Gly Gly Glu  Lys Gln Trp 
    1250                 1255                 1260             


Ile Cys  Lys Asp Thr Ile Thr  His Gly Asp Thr Asn  Gly Ala Cys 
    1265                 1270                 1275             


Ile Pro  Pro Arg Thr Gln Asn  Leu Cys Val Gly Glu  Leu Trp Asp 
    1280                 1285                 1290             


Lys Arg  Tyr Gly Gly Arg Ser  Asn Ile Lys Asn Asp  Thr Lys Glu 
    1295                 1300                 1305             


Ser Leu  Lys Asn Lys Leu Lys  Asn Ala Ile Gln Lys  Glu Thr Glu 
    1310                 1315                 1320             


Leu Leu  Tyr Glu Tyr His Asp  Lys Gly Thr Ala Ile  Ile Ser Gln 
    1325                 1330                 1335             


Asn Asp  Lys Lys Glu Lys Ala  Asn Asn Asn Asn Ser  Asn Gly Leu 
    1340                 1345                 1350             


Pro Lys  Gly Phe Cys His Ala  Val Gln Arg Ser Phe  Ile Asp Tyr 
    1355                 1360                 1365             


Lys Asn  Met Ile Leu Gly Thr  Ser Val Asn Ile Tyr  Glu His Ile 
    1370                 1375                 1380             


Gly Lys  Leu Gln Glu Asp Ile  Lys Lys Ile Ile Glu  Gln Glu Thr 
    1385                 1390                 1395             


Thr Lys  Gln Asn Gly Lys Thr  Val Gly Gly Ala Asp  Lys Val Asn 
    1400                 1405                 1410             


Ala Trp  Trp Lys Gly Ile Glu  Gly Glu Met Trp Gly  Ala Val Arg 
    1415                 1420                 1425             


Cys Ala  Ile Thr Lys Ile Asn  Lys Lys Lys Lys Asn  Gly Thr Phe 
    1430                 1435                 1440             


Ser Ile  Asp Glu Cys Gly Ile  Phe Pro Pro Thr Gly  Asn Asp Glu 
    1445                 1450                 1455             


Asp Gln  Ser Val Ser Trp Phe  Lys Glu Trp Gly Glu  Gln Phe Cys 
    1460                 1465                 1470             


Ile Glu  Arg Leu Gln Tyr Glu  Gln Asn Ile Arg Glu  Ala Cys Thr 
    1475                 1480                 1485             


Ile Asn  Gly Lys Asn Gly Lys  Lys Cys Ile Asn Ser  Lys Ser Gly 
    1490                 1495                 1500             


Gln Glu  Asp Lys Ile Gln Gly  Ala Cys Lys Arg Lys  Cys Glu Lys 
    1505                 1510                 1515             


Tyr Lys  Lys Tyr Ile Ser Glu  Lys Lys Gln Glu Trp  Asp Lys Gln 
    1520                 1525                 1530             


Lys Thr  Lys Tyr Glu Asn Lys  Tyr Val Gly Lys Ser  Ala Ser Asp 
    1535                 1540                 1545             


Leu Leu  Lys Glu Asn Tyr Pro  Glu Cys Ile Ser Ala  Asn Phe Asp 
    1550                 1555                 1560             


Phe Ile  Phe Asn Asp Asn Ile  Glu Tyr Lys Thr Tyr  Tyr Pro Tyr 
    1565                 1570                 1575             


Gly Asp  Tyr Ser Ser Ile Cys  Ser Cys Glu Gln Val  Lys Tyr Tyr 
    1580                 1585                 1590             


Glu Tyr  Asn Asn Ala Glu Lys  Lys Asn Asn Lys Ser  Leu Cys His 
    1595                 1600                 1605             


Glu Lys  Gly Asn Asp Arg Thr  Trp Ser Lys Lys Tyr  Ile Lys Lys 
    1610                 1615                 1620             


Leu Glu  Asn Gly Arg Thr Leu  Glu Gly Val Tyr Val  Pro Pro Arg 
    1625                 1630                 1635             


Arg Gln  Gln Leu Cys Leu Tyr  Glu Leu Phe Pro Ile  Ile Ile Lys 
    1640                 1645                 1650             


Asn Glu  Glu Gly Met Glu Lys  Ala Lys Glu Glu Leu  Leu Glu Thr 
    1655                 1660                 1665             


Leu Gln  Ile Ala Ala Glu Arg  Glu Ala Tyr Tyr Leu  Trp Lys Gln 
    1670                 1675                 1680             


Tyr His  Ala His Asn Asp Thr  Thr Tyr Leu Ala His  Lys Lys Ala 
    1685                 1690                 1695             


Cys Cys  Ala Ile Arg Gly Ser  Phe Tyr Asp Leu Glu  Asp Ile Ile 
    1700                 1705                 1710             


Lys Gly  Asn Asp Leu Val His  Asp Glu Tyr Thr Lys  Tyr Ile Asp 
    1715                 1720                 1725             


Ser Lys  Leu Asn Lys Ile Phe  Gly Ser Ser Asn Lys  Asn Asp Ile 
    1730                 1735                 1740             


Glu Thr  Lys Arg Ala Arg Thr  Asp Trp Trp Glu Asn  Glu Ala Ile 
    1745                 1750                 1755             


Gly Val  Ala Asn Gly Thr Asp  His Lys Thr Ile Arg  Gln Leu Val 
    1760                 1765                 1770             


Trp Asp  Ala Met Gln Ser Gly  Val Arg Tyr Ala Val  Glu Glu Lys 
    1775                 1780                 1785             


Lys Lys  Lys Lys Gln Asn Glu  Asn Phe Pro Pro Cys  Met Gly Val 
    1790                 1795                 1800             


Glu His  Ile Gly Ile Ala Lys  Pro Gln Phe Ile Arg  Trp Leu Glu 
    1805                 1810                 1815             


Glu Trp  Thr Asn Glu Phe Cys  Glu Glu Tyr Thr Lys  Tyr Phe Gly 
    1820                 1825                 1830             


Ala Ile  Asn Ser Lys Cys Asn  Leu Arg Lys Gly Ala  Asp Asp Cys 
    1835                 1840                 1845             


Asp Asp  Asn Ser Asn Ile Glu  Cys Lys Arg Ala Cys  Ala Asn Tyr 
    1850                 1855                 1860             


Thr Asn  Trp Leu Asn Pro Lys  Arg Ile Glu Trp Asn  Gly Met Ser 
    1865                 1870                 1875             


Asn Tyr  Tyr Asn Lys Ile Tyr  Arg Lys Ser Asn Lys  Glu Ser Glu 
    1880                 1885                 1890             


Asp Gly  Lys Asp Tyr Ser Met  Ile Met Glu Pro Thr  Val Ile Asp 
    1895                 1900                 1905             


Tyr Leu  Asn Lys Arg Cys His  Gly Glu Ile Asn Gly  Asn Tyr Ile 
    1910                 1915                 1920             


Cys Cys  Ser Cys Lys Asn Ile  Gly Glu Asn Ser Thr  Ser Pro Val 
    1925                 1930                 1935             


Ala Asn  Lys Lys Ala Gln Arg  Lys Asp Glu Gln Cys  Glu Asp Asn 
    1940                 1945                 1950             


Lys Gly  Pro Leu Asp Leu Met  Asn Glu Val Leu Asn  Lys Met Asp 
    1955                 1960                 1965             


Glu Lys  Tyr Ser Glu His Lys  Met Lys Cys Thr Glu  Val Tyr Leu 
    1970                 1975                 1980             


Glu His  Val Glu Glu Gln Leu  Lys Glu Ile Asp Asn  Ala Ile Lys 
    1985                 1990                 1995             


Asp Tyr  Lys Leu Tyr Pro Leu  Asp Arg Cys Phe Asp  Asp Gln Thr 
    2000                 2005                 2010             


Lys Met  Lys Ile Cys Asp Leu  Ile Arg Asp Ala Ile  Gly Cys Lys 
    2015                 2020                 2025             


Asp Lys  Thr Lys Leu Asp Glu  Leu Asp Glu Trp Asn  Asp Met Asp 
    2030                 2035                 2040             


Leu Arg  Asp Pro Tyr Asn Lys  Tyr Lys Gly Val Leu  Ile Pro Pro 
    2045                 2050                 2055             


Arg Arg  Arg Gln Leu Cys Phe  Ser Arg Ile Val Arg  Gly Arg Ala 
    2060                 2065                 2070             


Asn Leu  Arg Ser Leu Asn Glu  Phe Lys Glu Glu Ile  Leu Lys Gly 
    2075                 2080                 2085             


Ala Gln  Ser Glu Gly Lys Phe  Leu Gly Asn Tyr Tyr  Lys Glu His 
    2090                 2095                 2100             


Lys Gly  Asn Tyr Tyr Asn Glu  Asp Lys Asp Lys Glu  Lys Ala Leu 
    2105                 2110                 2115             


Glu Ala  Met Lys Asn Ser Phe  Tyr Asp Tyr Glu Tyr  Ile Ile Lys 
    2120                 2125                 2130             


Gly Ser  Asp Ile Leu Glu Asn  Ile Gln Phe Lys Asp  Ile Lys Arg 
    2135                 2140                 2145             


Lys Leu  Asp Arg Leu Leu Glu  Lys Glu Thr Asn Asn  Thr Lys Lys 
    2150                 2155                 2160             


Val Asp  Asp Trp Trp Glu Thr  Asn Lys Lys Ser Ile  Trp Asn Ala 
    2165                 2170                 2175             


Met Leu  Cys Gly Tyr Lys Lys  Ser Gly Asn Lys Ile  Ile Asp Pro 
    2180                 2185                 2190             


Ser Trp  Cys Thr Ile Pro Thr  Thr Glu Lys Thr Pro  Gln Phe Leu 
    2195                 2200                 2205             


Arg Trp  Ile Lys Glu Trp Gly  Thr Asn Val Cys Ile  Gln Lys Glu 
    2210                 2215                 2220             


Lys Tyr  Lys Gln Asn Val Lys  Ser Glu Cys Ser Asn  Val Pro Asn 
    2225                 2230                 2235             


Asn Asn  Leu Gly Ser Gln Glu  Ser Glu Ser Asn Asn  Cys Thr Ser 
    2240                 2245                 2250             


Glu Ile  Arg Lys Tyr Gln Glu  Trp Ser Arg Lys Arg  Ser Ile Gln 
    2255                 2260                 2265             


Trp Glu  Ala Ile Ser Glu Arg  Tyr Lys Lys Tyr Lys  Gly Met Asp 
    2270                 2275                 2280             


Glu Phe  Lys Asn Thr Phe Lys  Asn Ile Lys Glu Pro  Asp Ala Asn 
    2285                 2290                 2295             


Thr Tyr  Leu Arg Glu His Cys  Ser Lys Cys Pro Cys  Gly Phe Asn 
    2300                 2305                 2310             


Asp Met  Lys Glu Ile Ala Asn  Asp Thr Glu Asn Lys  Gln Asp Ile 
    2315                 2320                 2325             


Phe Asn  Arg Ile Lys Glu Gln  Val Asp Ile Pro Ala  Glu Leu Glu 
    2330                 2335                 2340             


Asp Val  Ile Tyr Arg Leu Lys  His His Lys Tyr Asn  Ser Asn Asp 
    2345                 2350                 2355             


Tyr Ile  Cys Asn Lys Tyr Lys  Asn Ile Asn Val Asn  Lys Arg His 
    2360                 2365                 2370             


Lys Asn  Asp Asp Thr Phe Val  Thr Asp Asn Phe Val  Lys Lys Ser 
    2375                 2380                 2385             


Trp Glu  Ile Asn Lys Gly Val  Leu Ile Pro Pro Arg  Arg Lys Asn 
    2390                 2395                 2400             


Leu Phe  Leu Tyr Ile Asp Pro  Ser Lys Ile Cys Glu  Tyr Lys Lys 
    2405                 2410                 2415             


Asn Pro  Lys Leu Phe Asn Asp  Phe Ile Tyr Ser Ser  Ala Phe Thr 
    2420                 2425                 2430             


Glu Val  Glu Arg Leu Lys Ile  Val Tyr Gly Glu Ala  Lys Thr Lys 
    2435                 2440                 2445             


Val Ala  His Ala Met Lys Tyr  Ser Phe Ala Asp Ile  Gly Asn Ile 
    2450                 2455                 2460             


Ile Lys  Gly Asp Asp Met Met  Glu Asn Asn Ser Ser  Asp Lys Ile 
    2465                 2470                 2475             


Gly Lys  Ile Leu Gly Asp Thr  Asp Gly Gln Asn Glu  Lys Arg Lys 
    2480                 2485                 2490             


Ala Trp  Trp Asp Met Asn Lys  Tyr His Ile Trp Glu  Ser Met Leu 
    2495                 2500                 2505             


Cys Gly  Tyr Arg Glu Ala Gly  Gly Tyr Lys Glu Thr  Val Glu Lys 
    2510                 2515                 2520             


Leu Ser  Glu Lys Lys Gln Lys  Cys Thr Phe Pro Asp  Ile Glu Ser 
    2525                 2530                 2535             


Val Pro  Gln Phe Leu Arg Trp  Phe Gln Glu Trp Thr  Glu Asn Phe 
    2540                 2545                 2550             


Cys Thr  Lys Arg Lys Glu Leu  Tyr Glu Asp Val Gln  Lys Ile Cys 
    2555                 2560                 2565             


Ala Ser  Ala Glu Cys Asn Thr  Ser Asn Gly Ser Val  Asp Lys Ala 
    2570                 2575                 2580             


Glu Cys  Thr Lys Thr Cys Val  Asn Tyr Lys Asn Tyr  Val Leu Thr 
    2585                 2590                 2595             


Lys Lys  Thr Glu Tyr Glu Ile  Gln Lys Lys Lys Tyr  Asp Thr Glu 
    2600                 2605                 2610             


Phe Lys  Asn Gln Asn Ser Asn  Asp Lys Asp Ala Pro  Asp Tyr Ile 
    2615                 2620                 2625             


Lys Asp  Lys Cys Asn Asn Asn  Cys Asp Cys Ile Ser  Tyr His Ile 
    2630                 2635                 2640             


Asp Asp  Lys Lys Asn Trp Lys  Glu Pro Tyr Glu Thr  Phe Asp Asp 
    2645                 2650                 2655             


Asp Lys  Phe Lys Gly Lys Cys  Asp Cys Pro Lys Pro  Leu Pro Leu 
    2660                 2665                 2670             


Phe Ser  Asp Asn Thr Ser Asp  Ile Leu Gln Lys Thr  Ile Pro Phe 
    2675                 2680                 2685             


Gly Ile  Ala Leu Ala Leu Gly  Ser Ile Ala Phe Leu  Phe Met Lys 
    2690                 2695                 2700             


Lys Lys  Pro Lys Thr Pro Val  Asp Leu Leu Arg Val  Leu Asp Ile 
    2705                 2710                 2715             


His Lys  Gly Asp Tyr Gly Ile  Pro Thr Thr Lys Ser  Ser Asn Arg 
    2720                 2725                 2730             


Tyr Ile  Pro Tyr Val Ser Asp  Thr Tyr Lys Gly Lys  Thr Tyr Ile 
    2735                 2740                 2745             


Tyr Met  Glu Gly Asp Thr Ser  Gly Asp Asp Asp Lys  Tyr Ile Trp 
    2750                 2755                 2760             


Asp Leu  Ser Ser Ser Asp Ile  Thr Ser Ser Glu Ser  Glu Tyr Glu 
    2765                 2770                 2775             


Glu Leu  Asp Ile Asn Asp Ile  Tyr Val Pro Ser Leu  Pro Lys Tyr 
    2780                 2785                 2790             


Lys Thr  Leu Ile Glu Val Val  Leu Glu Pro Ser Lys  Arg Asp Thr 
    2795                 2800                 2805             


Phe Asn  Thr Ser Ser Gly Asp  Thr Phe Thr Asn Lys  Leu Thr Asp 
    2810                 2815                 2820             


Asp Glu  Trp Asn Gln Leu Lys  Gln Asp Phe Ile Glu  Gln Tyr Leu 
    2825                 2830                 2835             


Gln Asn  Ile Gln Lys Asp Phe  Ile Leu His Asp Ser  Val Asn Glu 
    2840                 2845                 2850             


Lys Pro  Phe Ile Thr Gln Ile  Gln Asp Arg Phe Leu  Asp Ser Ser 
    2855                 2860                 2865             


His Glu  Glu Val Ile Tyr Asn  Ile Asp Trp Asn Val  Pro Glu Asn 
    2870                 2875                 2880             


Ile Asn  Arg Ile Thr Asn Asn  Met Asp Asp Pro Lys  Tyr Ser Ser 
    2885                 2890                 2895             


Asn Asn  Leu Tyr Thr Gly Thr  Asp Leu Ile Asn Asp  Ser Leu Asn 
    2900                 2905                 2910             


Gly Asn  Gln Tyr Ile Asp Ile  Tyr Asp Glu Met Leu  Lys Arg Lys 
    2915                 2920                 2925             


Glu Asn  Glu Leu Phe Gly Thr  Tyr His Thr Lys Tyr  Thr Thr Phe 
    2930                 2935                 2940             


Asn Ser  Val Ser Lys Gln Thr  Pro Ser Asp Pro Ile  Ile Asn Gln 
    2945                 2950                 2955             


Leu Asp  Leu Tyr His Asn Trp  Met Asp Lys His Arg  Asp Ile Cys 
    2960                 2965                 2970             


Glu Gln  Trp Lys Thr Lys Glu  Asp Met Leu Tyr Lys  Leu Asn Glu 
    2975                 2980                 2985             


Val Trp  Asn Met Glu Arg Lys  Glu Tyr Leu Leu Asp  Ile Gln Pro 
    2990                 2995                 3000             


Ser Thr  Leu Asp Asp Ile His  Lys Ile Asn Asp Glu  Thr Tyr Asn 
    3005                 3010                 3015             


Ile Ile  Ser Thr Asn Asn Ile  Tyr Asp His Pro Ser  Gln Glu Thr 
    3020                 3025                 3030             


Pro Leu  Gln Leu Leu Gly Ser  Thr Asn Ile Ile Pro  Ser Tyr Ile 
    3035                 3040                 3045             


Thr Thr  Glu Gln Asn Asn Gly  Leu Arg Thr Asn Ile  Ser Met Asp 
    3050                 3055                 3060             


Thr Tyr  Ile Asp Glu Thr Asn  Asn Asn Asn Val Val  Ala Thr Ser 
    3065                 3070                 3075             


Ile Ile  Gly Asp Asp Gln Met  Glu Asn Ser Tyr Asn  Cys 
    3080                 3085                 3090     


<210>  60
<211>  3290
<212>  PRT
<213>  Plasmodium falciparum

<400>  60

Met Asp Ser Lys Thr Thr Ile Gly Asp Lys Ile Glu Ala Tyr Leu Glu 
1               5                   10                  15      


Lys Lys Ser Asn Glu Ser Asp Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Arg 
        35                  40                  45              


Lys Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Glu Pro Cys Asp Ser Ile Pro Pro Pro Tyr Gly Asp Ile Asp Glu Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Lys Pro Glu Asn Val 
                85                  90                  95      


Phe Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Asn 
            100                 105                 110         


Leu Asn Val Glu Arg Ile Arg Asp Asn Asn Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Ile Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Lys Asn Ile Leu Glu 
            180                 185                 190         


Lys Gly Ser Thr Ile Gln Ser Asn Tyr Ser Lys Lys Asp Gln Asn Tyr 
        195                 200                 205             


Thr Lys Leu Arg Glu Asp Trp Trp Thr Lys Asn Arg Gln Lys Val Trp 
    210                 215                 220                 


Glu Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg 
225                 230                 235                 240 


Arg Trp Thr Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys Leu Glu Leu 
                245                 250                 255     


Cys Arg Lys Cys Gly His Tyr Glu Gly Lys Val Pro Thr Lys Leu Asp 
            260                 265                 270         


Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe 
        275                 280                 285             


Tyr Arg Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His Arg Glu 
    290                 295                 300                 


Glu Cys Thr Arg Glu Asp His Lys Ser Lys Glu Gly Ala Ser Tyr Cys 
305                 310                 315                 320 


Ser Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys 
                325                 330                 335     


Trp Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Lys Asp Leu Tyr 
            340                 345                 350         


Gln Gln Glu Asn Glu Thr Ser Ser Ser Ser Lys Lys Lys Ser Arg Tyr 
        355                 360                 365             


Asp Asp Tyr Val Lys Glu Phe Phe Lys Asn Phe Lys Gly Asp Asn Tyr 
    370                 375                 380                 


Lys Ser Leu Asp Asp Tyr Ile Lys Gly Asp Pro Tyr Ser Lys Glu Tyr 
385                 390                 395                 400 


Thr Thr Lys Leu Ser Phe Ile Leu Asn Pro Ser Asp Ala Asn Thr Ser 
                405                 410                 415     


Ser Glu Lys Ile Gln Lys Asn Asn Asp Glu Ala Cys Asn Cys Asn Glu 
            420                 425                 430         


Ser Glu Ile Ala Ser Val Glu Gln Ala Ser Ile Ser Asp Arg Ser Ser 
        435                 440                 445             


Gln Lys Ala Tyr Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys 
    450                 455                 460                 


Val Cys Lys His Val Lys Leu Gly Val Arg Glu Asn Asp Lys Val Leu 
465                 470                 475                 480 


Arg Val Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Glu Asn Cys 
                485                 490                 495     


Cys Phe Lys Asp Phe Leu Arg Ile Val Glu Glu Pro Arg Ile Asp Lys 
            500                 505                 510         


Asn Gln Arg Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Asn Asn Glu 
        515                 520                 525             


Glu Ala Cys Glu Lys Asn Leu Asp Glu Ala Leu Ala Ser Leu Thr Asn 
    530                 535                 540                 


Cys Tyr Lys Cys Asp Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn 
545                 550                 555                 560 


Asn Lys Trp Ile Trp Arg Lys Phe Pro Gly Asn Gly Glu Gly Leu Gln 
                565                 570                 575     


Lys Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu 
            580                 585                 590         


Cys Leu Val Cys Leu His Glu Lys Glu Gly Lys Thr Gln Glu Leu Lys 
        595                 600                 605             


Asn Ile Arg Thr Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Asp Ala 
    610                 615                 620                 


Phe His Glu Gly Lys Asn Leu Lys Thr Ser His Gln Lys Lys Asn Ala 
625                 630                 635                 640 


Glu Asn Lys Lys Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp 
                645                 650                 655     


Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr 
            660                 665                 670         


Lys Asp Leu Glu Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg 
        675                 680                 685             


Lys Tyr Ile Lys Lys Asn Ile Ser Thr Glu Gln His Thr Ser Tyr Ser 
    690                 695                 700                 


Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr 
705                 710                 715                 720 


Ile Trp Thr Ala Met Lys His Gly Ala Glu Met Asn Ser Thr Met Cys 
                725                 730                 735     


Asn Val Asp Gly Ser Val Thr Gly Ser Ser Asp Ser Gly Ser Thr Thr 
            740                 745                 750         


Cys Ser Gly Asp Asn Gly Ser Ile Ser Cys Asp Asp Ile Pro Thr Ile 
        755                 760                 765             


Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His 
    770                 775                 780                 


Phe Cys Lys Gln Arg Gln Ala Lys Val Asn Ala Val Ile Lys Asn Cys 
785                 790                 795                 800 


Asn Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Asp Cys Lys Thr 
                805                 810                 815     


Lys Cys Lys Val Ala Cys Asp Ala Tyr Lys Lys Phe Ile Glu Glu Cys 
            820                 825                 830         


Arg Thr Ala Ala Glu Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp 
        835                 840                 845             


Tyr Gln Ile Tyr Met Arg Tyr Ser Lys His Ile Glu Asp Ala Lys Arg 
    850                 855                 860                 


Asn Arg Lys Ala Gly Thr Lys Ser Cys Gly Thr Ser Thr Ala Glu Ser 
865                 870                 875                 880 


Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp 
                885                 890                 895     


Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Asn Val Leu Asp Glu 
            900                 905                 910         


Asn Asn Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr 
        915                 920                 925             


Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Lys Asn Cys Asp Ile Gln Lys 
    930                 935                 940                 


Asp Lys Ser Lys Ser Gln Ser Cys Asn Thr Ala Val Val Val Asn Val 
945                 950                 955                 960 


Pro Ser Pro Leu Gly Asn Thr Pro Tyr Glu Tyr Lys Tyr Ala Cys Glu 
                965                 970                 975     


Cys Lys Ile Pro Thr Thr Glu Glu Thr Cys Asp Asp Arg Lys Glu Tyr 
            980                 985                 990         


Met Asn Gln Trp Ile Ser Asp Asn  Thr Lys Asn Pro Lys  Gly Ser Gly 
        995                 1000                 1005             


Ser Thr  Asn Asn Asp Tyr Glu  Leu Tyr Thr Tyr Asn  Gly Val Gln 
    1010                 1015                 1020             


Ile Lys  Gln Ala Ala Gly Arg  Ser Ser Ser Thr Lys  Leu Asp Asp 
    1025                 1030                 1035             


Lys Asp  Val Met Phe Phe Asn  Leu Phe Glu Gln Trp  Asn Lys Glu 
    1040                 1045                 1050             


Ile Gln  Tyr Gln Ile Glu Gln  Tyr Met Thr Asn Thr  Lys Ile Ser 
    1055                 1060                 1065             


Cys Ile  Asp Glu Lys Glu Val  Leu Asp Ser Val Ser  Asp Glu Gly 
    1070                 1075                 1080             


Thr Pro  Lys Val Arg Gly Gly  Tyr Glu Asp Gly Arg  Asn Asn Asn 
    1085                 1090                 1095             


Thr Asp  Gln Gly Thr Asn Cys  Lys Glu Lys Cys Glu  Cys Tyr Lys 
    1100                 1105                 1110             


Leu Trp  Met Glu Lys Ile Lys  Lys Gln Trp Glu Thr  Gln Asn Gln 
    1115                 1120                 1125             


Asn Tyr  Asn Lys Phe Glu Lys  Lys Thr Ser Ser Tyr  Ala Asn Lys 
    1130                 1135                 1140             


Gly Pro  Gln Asn Lys Lys Val  Val Ser Leu Ser His  Phe Leu Phe 
    1145                 1150                 1155             


Phe Ser  Cys Trp Glu Glu Tyr  Ile Gln Lys Tyr Phe  Asn Gly Asp 
    1160                 1165                 1170             


Trp Ser  Lys Ile Lys Asn Ile  Gly Ser Asp Thr Phe  Glu Tyr Leu 
    1175                 1180                 1185             


Ile Lys  Lys Cys Gly Asn Asp  Ser Gly Asp Gly Glu  Thr Ile Phe 
    1190                 1195                 1200             


Asn Lys  Lys Leu Lys Asn Ala  His Ile Lys Cys Asn  Glu Asn Ala 
    1205                 1210                 1215             


Ser Lys  Asn Thr Lys Ile Asn  Lys Ser Glu Thr Ser  Ser Asp Cys 
    1220                 1225                 1230             


Ser Glu  Pro Ile Tyr Ile Arg  Gly Cys Gln Ser Lys  Thr Tyr Asp 
    1235                 1240                 1245             


Gly Phe  Ile Ser Pro Gly Lys  Gly Gly Glu Lys Lys  Trp Ile Cys 
    1250                 1255                 1260             


Lys Asp  Thr Ile Thr His Gly  Asp Thr Asn Gly Ala  Cys Ile Pro 
    1265                 1270                 1275             


Pro Arg  Thr Gln Asn Leu Cys  Val Gly Glu Leu Trp  Asp Lys Ser 
    1280                 1285                 1290             


Tyr Gly  Gly Arg Ser Asn Ile  Lys Asn Asp Thr Lys  Glu Ser Leu 
    1295                 1300                 1305             


Lys Asn  Lys Leu Lys Asn Ala  Ile Gln Lys Glu Thr  Glu Leu Leu 
    1310                 1315                 1320             


Tyr Glu  Tyr His Asp Lys Gly  Thr Ala Ile Ile Ser  Gln Asn Asp 
    1325                 1330                 1335             


Lys Lys  Glu Lys Ala Asn Asn  Asn Asn Ser Asn Gly  Leu Pro Lys 
    1340                 1345                 1350             


Gly Phe  Cys His Ala Val Gln  Arg Ser Phe Ile Asp  Tyr Lys Asn 
    1355                 1360                 1365             


Met Ile  Leu Gly Thr Ser Val  Asn Ile Tyr Glu His  Ile Gly Lys 
    1370                 1375                 1380             


Leu Gln  Glu Asp Ile Lys Lys  Ile Ile Glu Gln Glu  Arg Thr Lys 
    1385                 1390                 1395             


Thr Lys  Glu Lys Thr Val Gly  Ser Gly Ala Asp Lys  Val Asn Asp 
    1400                 1405                 1410             


Trp Trp  Lys Glu Ile Glu Gly  Glu Met Trp Asp Ala  Val Arg Cys 
    1415                 1420                 1425             


Gly Ile  Thr Lys Ile Asn Lys  Lys Asn Asn Asn Ser  Ile Phe Asn 
    1430                 1435                 1440             


Gly Asn  Glu Cys Gly Asn Ser  Pro Ser Thr Gly Asn  Asp Glu Asp 
    1445                 1450                 1455             


Gln Ser  Val Ser Trp Phe Lys  Glu Trp Gly Glu Gln  Phe Cys Ile 
    1460                 1465                 1470             


Glu Arg  Leu Gln Tyr Glu Lys  Asn Ile Arg Glu Ala  Cys Thr Ile 
    1475                 1480                 1485             


Asn Gly  Lys Asn Glu Lys Lys  Cys Ile Asn Ser Lys  Ser Gly Gln 
    1490                 1495                 1500             


Gly Asp  Lys Ile Gln Gly Ala  Cys Lys Arg Lys Cys  Glu Lys Tyr 
    1505                 1510                 1515             


Lys Lys  Tyr Ile Ser Glu Lys  Lys Gln Glu Trp Asp  Lys Gln Lys 
    1520                 1525                 1530             


Thr Lys  Tyr Glu Asn Lys Tyr  Val Gly Lys Ser Ala  Ser Asp Leu 
    1535                 1540                 1545             


Leu Lys  Glu Asn Tyr Pro Glu  Cys Ile Ser Ala Asn  Phe Asp Phe 
    1550                 1555                 1560             


Ile Phe  Asn Asp Lys Ala Asp  His Lys Lys Tyr Tyr  Pro Tyr Gly 
    1565                 1570                 1575             


Asp Tyr  Asn Ser Ile Cys Ser  Cys Glu Gln Val Lys  Tyr Tyr Glu 
    1580                 1585                 1590             


Tyr Asn  Lys Asp Lys Gly Gln  Ser Asn Lys Ser Leu  Cys His Glu 
    1595                 1600                 1605             


Lys Gly  Asn Asp Arg Thr Trp  Ser Lys Lys Tyr Ile  Lys Lys Leu 
    1610                 1615                 1620             


Glu Asn  Gly Arg Thr Leu Glu  Gly Val Tyr Val Pro  Pro Arg Arg 
    1625                 1630                 1635             


Gln Gln  Leu Cys Leu Tyr Glu  Leu Phe Pro Ile Ile  Ile Lys Lys 
    1640                 1645                 1650             


Glu Lys  Asp Met Glu Asn Val  Lys Lys Glu Leu Leu  Glu Thr Leu 
    1655                 1660                 1665             


Gln Ile  Val Ala Glu Arg Glu  Ala Tyr Tyr Leu Trp  Lys Gln Tyr 
    1670                 1675                 1680             


Asn Pro  Thr Gly Lys Gly Ile  Asp Asp Ala Asn Lys  Lys Ala Cys 
    1685                 1690                 1695             


Cys Ala  Ile Arg Gly Ser Phe  Tyr Asp Leu Glu Asp  Ile Ile Lys 
    1700                 1705                 1710             


Gly Asn  Asp Leu Val His Asp  Glu Tyr Thr Lys Tyr  Ile Asp Ser 
    1715                 1720                 1725             


Lys Leu  Asn Glu Ile Phe Gly  Ser Ser Asn Lys Asn  Asp Ile Glu 
    1730                 1735                 1740             


Thr Lys  Arg Ala Arg Thr Asp  Trp Trp Glu Asn Glu  Thr Ile Thr 
    1745                 1750                 1755             


Asn Arg  Thr Asp Arg Lys Thr  Ile Arg Gln Leu Val  Trp Asp Ala 
    1760                 1765                 1770             


Met Gln  Ser Gly Val Arg Tyr  Ala Val Glu Glu Lys  Asn Glu Asn 
    1775                 1780                 1785             


Phe Pro  Pro Cys Met Gly Val  Glu His Ile Gly Ile  Ala Lys Pro 
    1790                 1795                 1800             


Gln Phe  Ile Arg Trp Leu Glu  Glu Trp Thr Asn Glu  Phe Cys Glu 
    1805                 1810                 1815             


Glu Tyr  Thr Lys Tyr Phe Glu  Asp Met Lys Ser Lys  Cys Asp Leu 
    1820                 1825                 1830             


Arg Lys  Gly Ala Asp Asp Cys  Gly Asp Asn Thr Asn  Ile Glu Cys 
    1835                 1840                 1845             


Lys Arg  Ala Cys Ala Asn Tyr  Thr Asn Trp Leu Asn  Pro Lys Arg 
    1850                 1855                 1860             


Ile Glu  Trp Asn Gly Met Ser  Asn Tyr Tyr Asn Lys  Ile Tyr Arg 
    1865                 1870                 1875             


Lys Ser  Asn Lys Glu Ser Glu  Asp Gly Lys Asp Tyr  Ser Met Ile 
    1880                 1885                 1890             


Met Glu  Pro Thr Val Ile Asp  Tyr Leu Asn Lys Arg  Cys Asn Gly 
    1895                 1900                 1905             


Glu Ile  Asn Gly Asn Tyr Ile  Cys Cys Ser Cys Lys  Asn Ile Gly 
    1910                 1915                 1920             


Glu Asn  Tyr Asn Pro Ser Pro  Ala Gln Lys Thr Lys  Gly Ser Lys 
    1925                 1930                 1935             


Lys Lys  Asp Glu Gln Cys Glu  Asp Asn Lys Gly Pro  Leu Asp Leu 
    1940                 1945                 1950             


Met Asn  Glu Val Leu Asn Lys  Met Asp Pro Lys Tyr  Ser Lys Leu 
    1955                 1960                 1965             


Asn Leu  Lys Cys Thr Glu Val  Tyr Leu Asp His Ile  Glu Glu Gln 
    1970                 1975                 1980             


Leu Lys  Glu Ile Asp Asn Ala  Ile Lys Asp Tyr Lys  Leu Tyr Pro 
    1985                 1990                 1995             


Leu Asp  Arg Cys Phe Asp Asp  Gln Thr Lys Met Lys  Ile Cys Asp 
    2000                 2005                 2010             


Leu Ile  Gly Asp Ala Ile Gly  Cys Lys His Lys Ile  Asn Leu Asp 
    2015                 2020                 2025             


Glu Leu  Asp Glu Trp Asn Asp  Val Asp Met Arg Gly  Thr Tyr Asn 
    2030                 2035                 2040             


Lys His  Lys Gly Val Leu Ile  Pro Pro Arg Arg Arg  Gln Leu Cys 
    2045                 2050                 2055             


Phe Ser  Arg Ile Val Arg Gly  Pro Ala Asn Leu Arg  Asn Leu Asn 
    2060                 2065                 2070             


Glu Phe  Lys Glu Glu Ile Leu  Lys Gly Ala Gln Ser  Glu Gly Lys 
    2075                 2080                 2085             


Phe Leu  Gly Asn Tyr Tyr Asn  Glu Asp Lys Asp Lys  Glu Lys Lys 
    2090                 2095                 2100             


Glu Asp  Arg Lys Glu Lys Ala  Leu Glu Ala Met Lys  Asn Ser Phe 
    2105                 2110                 2115             


Tyr Asp  Tyr Glu Tyr Ile Ile  Lys Gly Ser Asp Ile  Leu Glu Asn 
    2120                 2125                 2130             


Ile Glu  Phe Lys Asp Ile Lys  Arg Lys Leu Asp Lys  Leu Leu Thr 
    2135                 2140                 2145             


Lys Glu  Thr Asn Asn Thr Lys  Lys Ala Glu Asp Trp  Trp Lys Val 
    2150                 2155                 2160             


Asn Asn  Lys Ser Ile Trp Asn  Ala Met Leu Cys Gly  Tyr Lys Lys 
    2165                 2170                 2175             


Ser Gly  Asn Lys Ile Ile Asp  Pro Ser Trp Cys Lys  Ile Pro Thr 
    2180                 2185                 2190             


Thr Glu  Thr Pro Pro Gln Phe  Leu Arg Trp Ile Lys  Glu Trp Gly 
    2195                 2200                 2205             


Thr Asn  Val Cys Ile Gln Lys  Glu Lys Tyr Lys Gln  Asn Val Lys 
    2210                 2215                 2220             


Leu Glu  Cys Ser Asn Val Ser  Asn Ile Asp Leu Ser  Leu Gln Ala 
    2225                 2230                 2235             


Leu Glu  Ser Lys Asn Cys Thr  Ser Glu Ile Arg Lys  Tyr Gln Glu 
    2240                 2245                 2250             


Trp Ser  Arg Lys Arg Ser Ile  Gln Trp Glu Ala Ile  Ser Glu Arg 
    2255                 2260                 2265             


Tyr Arg  Lys Tyr Lys Gly Met  Asp Glu Phe Lys Asn  Val Lys Glu 
    2270                 2275                 2280             


Pro Asp  Ala Asn Glu Tyr Leu  Lys Glu His Cys Ser  Lys Cys Pro 
    2285                 2290                 2295             


Cys Gly  Phe Asn Asp Met Lys  Glu Ile Ala Asn Asp  Thr Glu Asn 
    2300                 2305                 2310             


Lys Gln  Asp Ile Phe Lys Gln  Ile Lys Glu Gln Val  Asp Ile Pro 
    2315                 2320                 2325             


Ala Glu  Leu Glu Asp Val Ile  Tyr Arg Leu Lys His  His Lys Tyr 
    2330                 2335                 2340             


Asn Ser  Asn Asp Tyr Ile Cys  Asn Lys Tyr Lys Asn  Ile His Asp 
    2345                 2350                 2355             


Arg Met  Lys Lys Asn Asn Asp  Asn Ile Trp Thr Asp  Leu Leu Val 
    2360                 2365                 2370             


Lys Lys  Ser Trp Glu Ile Ser  Asn Gly Val Leu Ile  Pro Pro Arg 
    2375                 2380                 2385             


Arg Lys  Asn Leu Phe Leu Lys  Ile Asp Gln Ser Asp  Ile Cys Lys 
    2390                 2395                 2400             


Tyr Lys  Lys Asp Pro Lys Leu  Phe Asn Asp Phe Ile  Tyr Trp Ser 
    2405                 2410                 2415             


Ala Phe  Thr Glu Val Glu Arg  Leu Lys Ile Val Tyr  Arg Gln Asp 
    2420                 2425                 2430             


Lys Glu  Lys Val Val His Ala  Met Lys Tyr Ser Phe  Ala Asp Ile 
    2435                 2440                 2445             


Gly Asn  Ile Ile Lys Gly Asp  Asp Met Met Lys Ser  Pro Thr Ser 
    2450                 2455                 2460             


Lys Tyr  Ile Glu Gln Ile Phe  Lys Gly Thr Glu Tyr  Ser Gly Ile 
    2465                 2470                 2475             


Asp Ser  Glu Thr Trp Trp Asp  Met Asn Lys Tyr His  Val Trp Glu 
    2480                 2485                 2490             


Ser Met  Leu Cys Ala Tyr Gln  Lys Asp Asn Lys Lys  Ile Glu Phe 
    2495                 2500                 2505             


Thr Ser  His Asp Cys Lys Met  Pro Asp Thr Glu Lys  Thr Pro Gln 
    2510                 2515                 2520             


Phe Leu  Arg Trp Leu Ile Glu  Trp Ser Lys Gln Val  Cys Ala His 
    2525                 2530                 2535             


Lys Leu  Ser Lys Ala Lys Tyr  Val Lys Glu Asn Cys  Ser Asn Tyr 
    2540                 2545                 2550             


Ile Lys  Asp Lys Glu Ser Asp  Lys Glu Gln Cys Ile  Asn Ala Ser 
    2555                 2560                 2565             


Asn Ile  Tyr Ile Gln Trp Met  Asn Lys Gln Lys Glu  Pro Trp Lys 
    2570                 2575                 2580             


Ile Leu  Ser Asn Ile Tyr Thr  Asn Tyr Lys Asn Glu  Lys Asn Met 
    2585                 2590                 2595             


Asn Tyr  Pro Asn Leu Pro Arg  Asn Ala Ser Tyr Tyr  Val Arg Glu 
    2600                 2605                 2610             


Lys Cys  Pro Glu Cys Ile Cys  Asn Leu Glu His Leu  Glu Glu Lys 
    2615                 2620                 2625             


Glu Asn  Gln Asn His Gln Asn  Gly Asp His Leu Ile  Glu Glu Ala 
    2630                 2635                 2640             


Ile Asn  Lys Ala Lys Met Asp  Leu Pro Asp Thr Lys  Trp Gly Ile 
    2645                 2650                 2655             


Ser Trp  Gly Pro Trp Lys Val  Asn Trp Glu Asn Met  Phe Phe Ile 
    2660                 2665                 2670             


Ser Ser  Phe Phe Pro Arg Ile  Lys Ile Val Ser Arg  Asp Thr Ala 
    2675                 2680                 2685             


Ile Thr  Asn Asp Ile Ser Asn  Val Ser His Ser Lys  Asp Pro Val 
    2690                 2695                 2700             


Ala Lys  Asp Arg Ser Ile Asn  Asp Ala Met Val Asp  Val Val Asn 
    2705                 2710                 2715             


Ile Val  Thr Gln Pro Val Thr  Thr Val Ile Asp Asn  Val Thr Pro 
    2720                 2725                 2730             


Thr Leu  Gly Arg Glu Leu Asn  Lys Val Val Asn Pro  Ile Asn Asn 
    2735                 2740                 2745             


Ile Leu  Asn Glu Val Thr Thr  Ser Val Gln Ser Ser  Val Thr Lys 
    2750                 2755                 2760             


Val Lys  Glu Thr Gly Asn Lys  Ile Thr Glu Asp Ile  Lys Lys Ile 
    2765                 2770                 2775             


Ile Asp  Asn Met Gly Asn Ile  Met Glu Gly Ile Ile  Gln Ser Leu 
    2780                 2785                 2790             


Glu Lys  Thr Lys Glu Lys Glu  His Lys Glu Phe Lys  Ser Lys Gln 
    2795                 2800                 2805             


Ile Leu  Asp Ser Lys Glu Asn  Thr Tyr Pro Asn Thr  Ile Val Pro 
    2810                 2815                 2820             


Thr Asn  Met Glu Asp Val Leu  Thr Met Tyr His Lys  Ile Asp Ile 
    2825                 2830                 2835             


Ile Ala  Pro Ala Ile Ser Val  Gly Ile Ile Thr Leu  Gly Tyr Ala 
    2840                 2845                 2850             


Leu Tyr  Lys Ser Gly Leu Phe  Gly Phe Ile Gly Ser  Lys His Lys 
    2855                 2860                 2865             


Gly Glu  Asp Val Ile Glu Arg  Ile Arg Leu Leu Lys  Phe Ala Glu 
    2870                 2875                 2880             


Asn Lys  Leu Gly Ser Ser Thr  Ser Thr Tyr Thr Tyr  Lys Lys Tyr 
    2885                 2890                 2895             


Ser Gly  Glu Pro Val Gln Glu  Tyr Met Glu Met Gly  Ser Tyr Lys 
    2900                 2905                 2910             


Gly Gln  Thr Tyr Ile Tyr Ile  Glu Gly Asp Asp Thr  Asp Glu Asp 
    2915                 2920                 2925             


Tyr Ile  Glu Asn Ile Ser Ser  Thr Asp Ala Ser Ser  Glu Ser Glu 
    2930                 2935                 2940             


Tyr Asp  Glu Leu Asp Val Ser  His Ile Tyr Pro Tyr  Arg Lys Pro 
    2945                 2950                 2955             


Lys Tyr  Lys Thr Leu Ile Glu  Leu Ile Leu Glu Pro  Asn Asn Lys 
    2960                 2965                 2970             


Asn Glu  Asp Thr Tyr Asp Thr  Pro Ser Tyr Gln Lys  Asp Asp Asn 
    2975                 2980                 2985             


Asp Lys  Pro Thr Asp Asp Glu  Trp Asn Gln Leu Lys  Asn Asp Phe 
    2990                 2995                 3000             


Ile Leu  Gln Phe Leu Val Asp  Glu Glu Pro Lys Asp  Leu Asn Lys 
    3005                 3010                 3015             


His Leu  Pro Asp Lys Pro Ser  Thr Asp Asn Pro Ser  Asp Glu Ile 
    3020                 3025                 3030             


Phe Met  Asp Asp Glu Lys Pro  Phe Ile Ile Ser Ile  Gln Asp Arg 
    3035                 3040                 3045             


Ser Leu  Asn Asn Gly Glu Ser  Val Thr Tyr Tyr Met  Asn Gly Asn 
    3050                 3055                 3060             


Ala Gln  Ser Asn Met Asp Ile  Ser Thr Asn Asn Glu  Tyr Val Thr 
    3065                 3070                 3075             


Lys Ile  Thr Gln Asn Arg Ser  Tyr Ser Gly Met Asp  Leu Ile Asn 
    3080                 3085                 3090             


Cys Ser  Leu Thr Arg Lys Ser  Asn Val Asn Ile Tyr  Gly Glu Leu 
    3095                 3100                 3105             


Leu Lys  Arg Lys Glu Lys Glu  Leu His Ala Met Glu  Tyr Asn Pro 
    3110                 3115                 3120             


Ile Trp  Leu Leu Pro Lys Phe  Glu Pro Leu Ser Thr  Gln Gly Gln 
    3125                 3130                 3135             


Asn Asn  Phe Gln Phe Ile Asn  Ile Asn Phe Ile Asp  Lys Trp Leu 
    3140                 3145                 3150             


Asn Gln  Asn Arg Glu Ile Ile  Asn Lys Leu Asn Lys  Gly Asp Arg 
    3155                 3160                 3165             


Leu Glu  Tyr Leu Lys Asp Leu  Trp Met Lys Glu His  Asn Met Asn 
    3170                 3175                 3180             


Ser Ile  Thr His Leu Asp Ser  Thr Thr Thr Phe Ile  Asn Gly Asn 
    3185                 3190                 3195             


Thr Leu  Arg Arg Asn Ile Ser  Met Asp Gln Asn Ser  Leu Ser Glu 
    3200                 3205                 3210             


Asn Asn  Asp Pro Met Asp Leu  Asn Asn Asn Asn Pro  Leu Asn Phe 
    3215                 3220                 3225             


Ile Asp  Tyr Leu Glu Gln Ser  Ile Asn Glu Arg Asn  Asp Ile Phe 
    3230                 3235                 3240             


Asp Asp  Val Ile Phe Tyr Asp  Thr Met Glu Glu Ser  Gln Lys Asp 
    3245                 3250                 3255             


Ile Pro  Tyr Ser Lys Asp Tyr  Thr Asn Ser His Lys  Val Lys Ala 
    3260                 3265                 3270             


Pro Ile  Asn Leu His Ser Gly  Asn Lys Ser Glu Asn  Gly Thr Leu 
    3275                 3280                 3285             


Pro Val  
    3290 


<210>  61
<211>  3151
<212>  PRT
<213>  Plasmodium falciparum

<400>  61

Met Asp Ser Thr Ser Thr Ile Ala Asn Lys Ile Glu Glu Tyr Leu Lys 
1               5                   10                  15      


Glu Lys Ser Asn Glu Ser Asp Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Glu Tyr Tyr Arg Ser Gly Gly Asp Gly Asp Tyr Leu Arg 
        35                  40                  45              


Lys Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Asp Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Asp Glu Asn Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Asn 
            100                 105                 110         


Leu Asn Val Glu Arg Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Ile Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Lys Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu 
            180                 185                 190         


Asn Asp Lys Val Leu Gln Asp Lys Tyr Pro Asn Asp Asp Pro Lys Tyr 
        195                 200                 205             


Thr Lys Leu Arg Glu Gly Trp Trp Asn Ala Asn Arg Gln Lys Val Trp 
    210                 215                 220                 


Glu Val Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg 
225                 230                 235                 240 


Arg Trp Thr Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys Leu Glu Leu 
                245                 250                 255     


Cys Arg Lys Cys Gly His Tyr Glu Gly Lys Val Pro Thr Tyr Leu Asp 
            260                 265                 270         


Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe 
        275                 280                 285             


Tyr Arg Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His Arg Glu 
    290                 295                 300                 


Glu Cys Thr Arg Glu Asp Asp Lys Cys Lys Glu Gly Ala Ser Tyr Cys 
305                 310                 315                 320 


Ser Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys 
                325                 330                 335     


Trp Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr 
            340                 345                 350         


Glu Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp 
        355                 360                 365             


Asn Tyr Val Lys Asp Phe Phe Glu Lys Leu Glu Ala Asn Tyr Lys Ser 
    370                 375                 380                 


Leu Asp Asp Tyr Ile Lys Asp Asp Pro Tyr Phe Ala Glu Tyr Ala Thr 
385                 390                 395                 400 


Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Gly 
                405                 410                 415     


Glu Thr Ala Asn His Asn Asp Glu Val Cys Asn Pro Asn Glu Ser Glu 
            420                 425                 430         


Ile Ser Ser Val Gly Gln Ala Gln Thr Ser Gly Pro Ser Ser Asn Lys 
        435                 440                 445             


Thr Cys Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Val Cys 
    450                 455                 460                 


Lys Tyr Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Lys Ile 
465                 470                 475                 480 


Cys Val Ile Glu Asp Thr Ser Leu Ser Gly Val Asp Asn Cys Cys Cys 
                485                 490                 495     


Gln Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Asn Asn Glu Glu Ala Cys 
        515                 520                 525             


Glu Lys Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Asn Gln Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Asn Lys Trp 
545                 550                 555                 560 


Ile Trp Lys Lys Ser Ser Gly Asn Gly Glu Gly Leu Gln Lys Glu Tyr 
                565                 570                 575     


Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Tyr Leu Gly 
            580                 585                 590         


Asn Leu Arg Lys Leu Gly Asn Val Cys Glu Asp Val Lys Asp Ile Asn 
        595                 600                 605             


Phe Asp Thr Lys Glu Lys Phe Leu Ala Gly Cys Leu Ile Ala Ala Phe 
    610                 615                 620                 


His Glu Gly Lys Asn Leu Lys Thr Thr Tyr Leu Glu Lys Lys Lys Gly 
625                 630                 635                 640 


Asp Asn Gly Lys Lys Leu Cys Lys Asp Leu Lys Tyr Ser Phe Ala Asp 
                645                 650                 655     


Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Asp Phe Thr 
            660                 665                 670         


Lys Asn Val Glu Leu Asn Leu Gln Gln Ile Phe Gly Lys Leu Phe Arg 
        675                 680                 685             


Lys Tyr Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser 
    690                 695                 700                 


Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr 
705                 710                 715                 720 


Ile Trp Leu Ala Met Lys His Gly Ala Gly Met Asn Gly Thr Thr Cys 
                725                 730                 735     


Ser Ser Gly Ser Gly Asp Asn Gly Asp Ser Ser Ile Thr Gly Ser Ser 
            740                 745                 750         


Asp Ser Gly Ser Thr Thr Cys Ser Gly Asp Asn Gly Ser Ile Ser Cys 
        755                 760                 765             


Asp Asp Ile Pro Thr Ile Asp Phe Ile Pro Gln Tyr Leu Arg Phe Leu 
    770                 775                 780                 


Gln Glu Trp Val Glu Asn Phe Cys Glu Gln Arg Gln Ala Lys Val Asn 
785                 790                 795                 800 


Ala Val Ile Asn Ser Cys Asn Ser Cys Lys Asn Thr Ser Gly Glu Arg 
                805                 810                 815     


Lys Ile Gly Asp Thr Cys Asn Ser Asp Cys Lys Thr Glu Cys Lys Asn 
            820                 825                 830         


Lys Cys Glu Ala Tyr Lys Thr Phe Ile Asp Asn Val Gly Asp Gly Thr 
        835                 840                 845             


Ala Gly Ser Pro Trp Val Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr 
    850                 855                 860                 


Ser Lys His Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys 
865                 870                 875                 880 


Asn Cys Gly Ile Thr Thr Gly Thr Ile Ser Gly Glu Ser Ser Gly Ala 
                885                 890                 895     


Thr Ser Gly Val Thr Thr Thr Glu Asn Lys Cys Val Gln Ser Asp Ile 
            900                 905                 910         


Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser 
        915                 920                 925             


Ser Tyr Leu Ser Ile Val Leu Asp Glu Asn Asn Cys Gly Glu Asp Lys 
    930                 935                 940                 


Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Tyr Thr Thr Tyr Thr 
945                 950                 955                 960 


Thr Thr Lys Asn Cys Asp Ile Gln Lys Asp Lys Ser Lys Leu Gln Gln 
                965                 970                 975     


Ser Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly Asn Thr 
            980                 985                 990         


Pro His Glu Tyr Lys Tyr Ala Cys  Gln Cys Lys Ile Pro  Thr Thr Glu 
        995                 1000                 1005             


Glu Thr  Cys Asp Asp Arg Lys  Glu Tyr Met Asn Gln  Trp Ile Ile 
    1010                 1015                 1020             


Asp Asn  Thr Lys Asn Pro Lys  Gly Ser Arg Ser Thr  Asn Asn Asp 
    1025                 1030                 1035             


Tyr Glu  Leu Tyr Thr Tyr Asn  Gly Val Lys Glu Thr  Lys Pro Leu 
    1040                 1045                 1050             


Gly Thr  Leu Lys Ser Ser Lys  Leu Asp Asp Lys Asp  Val Met Phe 
    1055                 1060                 1065             


Phe Asn  Leu Phe Glu Gln Trp  Asn Lys Glu Ile Gln  Tyr Glu Ile 
    1070                 1075                 1080             


Glu Gln  Tyr Met Thr Asn Thr  Lys Ile Ser Cys Asn  Asn Glu Met 
    1085                 1090                 1095             


Lys Val  Leu Ser Ser Ser Ser  Glu Glu Ser Gln Asn  Gln Asn Gly 
    1100                 1105                 1110             


Ser Asp  His His Asp Gly Arg  Asn Asn Asn Ile Asn  Gln Gly Thr 
    1115                 1120                 1125             


Asn Cys  Lys Lys Asn Cys Glu  Cys Tyr Ser Leu Trp  Met Glu Lys 
    1130                 1135                 1140             


Ile Lys  Lys Gln Trp Gly Lys  Gln Lys Asn Asn Tyr  Asn Lys Phe 
    1145                 1150                 1155             


Gln Arg  Lys Gln Ile Tyr Asp  Gly Asn Asn Ala Ser  His Lys Lys 
    1160                 1165                 1170             


Glu Ile  Val Lys Leu Ser Asn  Phe Leu Phe Phe Ser  Cys Trp Glu 
    1175                 1180                 1185             


Glu Tyr  Ile Gln Lys Tyr Phe  Asn Gly Asp Trp Ser  Lys Ile Lys 
    1190                 1195                 1200             


Asn Ile  Gly Ser Asp Thr Phe  Glu Tyr Leu Ile Lys  Lys Cys Gly 
    1205                 1210                 1215             


Asn Asp  Ser Gly Asp Gly Glu  Thr Ile Phe Asn Lys  Lys Leu Lys 
    1220                 1225                 1230             


Asn Ala  His Ile Lys Cys Asn  Glu Asn Glu Ser Thr  Asp Thr Lys 
    1235                 1240                 1245             


Ile Asn  Lys Ser Glu Thr Ser  Ser Asp Cys Ser Glu  Pro Ile Tyr 
    1250                 1255                 1260             


Ile Arg  Gly Cys Gln Ser Lys  Thr Tyr Asp Gly Phe  Ile Ser Pro 
    1265                 1270                 1275             


Gly Lys  Gly Gly Glu Lys Lys  Trp Ile Cys Lys Asp  Thr Ile Thr 
    1280                 1285                 1290             


His Gly  Asp Thr Asn Gly Ala  Cys Ile Pro Pro Arg  Thr Gln Asn 
    1295                 1300                 1305             


Leu Cys  Val Gly Glu Leu Trp  Asp Lys Arg Tyr Gly  Gly Arg Ser 
    1310                 1315                 1320             


Asn Ile  Lys Asn Asp Thr Lys  Glu Ser Leu Lys Asn  Lys Leu Lys 
    1325                 1330                 1335             


Asn Ala  Ile Gln Lys Glu Thr  Glu Leu Leu Tyr Glu  Tyr His Asp 
    1340                 1345                 1350             


Lys Gly  Thr Ala Ile Ile Ser  Gln Asn Asp Lys Lys  Glu Lys Ala 
    1355                 1360                 1365             


Asn Asn  Asn Asn Ser Asn Gly  Leu Pro Lys Gly Phe  Cys His Ala 
    1370                 1375                 1380             


Val Gln  Arg Ser Phe Ile Asp  Tyr Lys Asn Met Ile  Leu Gly Thr 
    1385                 1390                 1395             


Ser Val  Asn Thr Tyr Glu Tyr  Ile Gly Lys Leu Gln  Glu Asp Ile 
    1400                 1405                 1410             


Lys Lys  Ile Ile Glu Gln Gly  Arg Lys Pro Lys Glu  Lys Arg Val 
    1415                 1420                 1425             


Gly Ser  Gly Ala Asp Lys Val  Asn Asp Trp Trp Lys  Glu Ile Glu 
    1430                 1435                 1440             


Lys Asp  Met Trp Gly Ala Val  Lys Cys Gly Ile Lys  Thr Ile Lys 
    1445                 1450                 1455             


Lys Gln  Lys Lys Asn Gly Thr  Phe Ser Ile Asp Glu  Cys Gly Val 
    1460                 1465                 1470             


Ser Pro  Pro Thr Gly Asn Asp  Glu Asp Gln Phe Val  Ser Trp Phe 
    1475                 1480                 1485             


Lys Glu  Trp Gly Glu Gln Phe  Cys Ile Glu Arg Leu  Gln Tyr Glu 
    1490                 1495                 1500             


Lys Asn  Ile Arg Glu Ala Cys  Thr Ile Asn Gly Lys  Asn Glu Lys 
    1505                 1510                 1515             


Lys Cys  Ile Asn Ser Lys Ser  Gly Gln Glu Asp Lys  Ile Gln Gly 
    1520                 1525                 1530             


Ala Cys  Lys Arg Lys Cys Glu  Lys Tyr Lys Lys Tyr  Ile Ser Glu 
    1535                 1540                 1545             


Lys Lys  Gln Glu Trp Asp Lys  Gln Lys Thr Lys Tyr  Glu Asn Lys 
    1550                 1555                 1560             


Tyr Val  Gly Lys Ser Ala Ser  Asp Leu Leu Lys Glu  Asn Tyr Pro 
    1565                 1570                 1575             


Glu Cys  Ile Ser Ala Asn Phe  Asp Phe Ile Phe Asn  Asp Lys Ala 
    1580                 1585                 1590             


Asp His  Lys Lys Tyr Tyr Pro  Tyr Gly Asp Tyr Asn  Ser Ile Cys 
    1595                 1600                 1605             


Ser Cys  Glu Gln Val Lys Tyr  Tyr Glu Tyr Asn Lys  Asp Lys Gly 
    1610                 1615                 1620             


Gln Asn  Asn Lys Ser Leu Cys  His Glu Lys Gly Asn  Asp Arg Thr 
    1625                 1630                 1635             


Trp Ser  Lys Lys Tyr Ile Lys  Lys Leu Glu Asn Gly  Arg Ser Leu 
    1640                 1645                 1650             


Glu Gly  Val Tyr Val Pro Pro  Arg Arg Gln Gln Leu  Cys Leu Tyr 
    1655                 1660                 1665             


Glu Leu  Phe Pro Ile Ile Ile  Lys Lys Glu Lys Asp  Met Glu Lys 
    1670                 1675                 1680             


Ala Lys  Glu Glu Leu Leu Glu  Thr Leu Lys Ile Val  Ala Glu Arg 
    1685                 1690                 1695             


Glu Ala  Tyr Tyr Leu Trp Lys  Gln Tyr His Ala His  Asn Asp Thr 
    1700                 1705                 1710             


Thr Tyr  Leu Ala His Lys Lys  Ala Cys Cys Ala Ile  Arg Gly Ser 
    1715                 1720                 1725             


Phe Tyr  Asp Leu Glu Asp Ile  Ile Lys Gly Asn Asp  Leu Val His 
    1730                 1735                 1740             


Asp Glu  Tyr Thr Lys Tyr Ile  Asp Ser Lys Leu Asn  Glu Ile Phe 
    1745                 1750                 1755             


Gly Ser  Ser Asn Thr Asn Asn  Ile Asp Thr Lys Arg  Ala Arg Thr 
    1760                 1765                 1770             


Asp Trp  Trp Glu Asn Glu Thr  Ile Thr Asn Gly Pro  Asp Arg Lys 
    1775                 1780                 1785             


Thr Ile  Arg Gln Leu Val Trp  Asp Ala Met Gln Ser  Gly Val Arg 
    1790                 1795                 1800             


Tyr Ala  Val Glu Glu Lys Lys  Glu Asn Phe Pro Pro  Cys Met Gly 
    1805                 1810                 1815             


Val Glu  His Ile Gly Ile Ala  Lys Pro Gln Phe Ile  Arg Trp Leu 
    1820                 1825                 1830             


Glu Glu  Trp Thr Asn Glu Phe  Cys Glu Glu Tyr Thr  Lys Tyr Phe 
    1835                 1840                 1845             


Glu Asp  Met Lys Ser Lys Cys  Asp Pro Pro Lys Ser  Ala Asp Asp 
    1850                 1855                 1860             


Cys Gly  Asp Asn Thr Asn Ile  Glu Cys Lys Lys Ala  Cys Ala Asn 
    1865                 1870                 1875             


Tyr Thr  Asn Trp Leu Asn Pro  Lys Arg Ile Glu Trp  Asn Gly Met 
    1880                 1885                 1890             


Ser Asn  Tyr Tyr Asn Lys Ile  Tyr Arg Lys Ser Asn  Lys Glu Ser 
    1895                 1900                 1905             


Glu Asp  Gly Lys Asp Tyr Ser  Met Ile Met Glu Pro  Thr Val Ile 
    1910                 1915                 1920             


Asp Tyr  Leu Asn Lys Arg Cys  Asn Gly Glu Ile Asn  Gly Asn Tyr 
    1925                 1930                 1935             


Ile Cys  Cys Ser Cys Lys Asn  Ile Gly Ala Tyr Asn  Thr Thr Ser 
    1940                 1945                 1950             


Gly Thr  Val Asn Lys Lys Leu  Gln Lys Lys Glu Thr  Glu Cys Glu 
    1955                 1960                 1965             


Asp Asn  Lys Gly Pro Leu Asp  Leu Met Asn Glu Val  Leu Asn Lys 
    1970                 1975                 1980             


Met Asp  Glu Lys Tyr Ser Ala  His Lys Met Lys Cys  Thr Glu Val 
    1985                 1990                 1995             


Tyr Leu  Asp His Val Glu Glu  Gln Leu Lys Glu Ile  Asp Asn Ala 
    2000                 2005                 2010             


Ile Lys  Asp Tyr Lys Leu Tyr  Pro Leu Asp Arg Cys  Phe Asp Asp 
    2015                 2020                 2025             


Gln Thr  Lys Met Lys Val Cys  Asp Leu Ile Gly Asp  Ala Ile Gly 
    2030                 2035                 2040             


Cys Lys  Asp Lys Thr Lys Leu  Asp Glu Leu Asp Glu  Trp Asn Asp 
    2045                 2050                 2055             


Val Asp  Met Arg Asp Pro Tyr  Asn Lys Tyr Lys Gly  Val Leu Ile 
    2060                 2065                 2070             


Pro Pro  Arg Arg Arg Gln Leu  Cys Phe Ser Arg Ile  Val Arg Gly 
    2075                 2080                 2085             


Pro Ala  Asn Leu Arg Asn Leu  Asn Glu Phe Lys Glu  Glu Ile Leu 
    2090                 2095                 2100             


Lys Gly  Ala Gln Ser Glu Gly  Lys Phe Leu Gly Asn  Tyr Tyr Lys 
    2105                 2110                 2115             


Glu His  Lys Asp Lys Glu Lys  Ala Leu Glu Ala Met  Lys Asn Ser 
    2120                 2125                 2130             


Phe Tyr  Asp Tyr Glu Tyr Ile  Ile Lys Gly Ser Asp  Met Leu Thr 
    2135                 2140                 2145             


Asn Ile  Glu Phe Lys Asp Ile  Lys Arg Lys Leu Asp  Lys Leu Leu 
    2150                 2155                 2160             


Thr Lys  Glu Thr Asn Asn Thr  Lys Lys Val Asp Asp  Trp Trp Glu 
    2165                 2170                 2175             


Thr Asn  Lys Lys Ser Ile Trp  Asn Ala Met Leu Cys  Gly Tyr Lys 
    2180                 2185                 2190             


Lys Ser  Gly Asn Lys Ile Ile  Asp Pro Ser Trp Cys  Thr Ile Pro 
    2195                 2200                 2205             


Thr Thr  Glu Thr Pro Pro Gln  Phe Leu Arg Trp Val  Lys Glu Trp 
    2210                 2215                 2220             


Gly Thr  Asn Val Cys Ile Gln  Lys Glu Lys Tyr Lys  Gln Asn Val 
    2225                 2230                 2235             


Lys Ser  Lys Cys Ser Asn Val  Pro Asn Asn Asn Leu  Gly Ser Gln 
    2240                 2245                 2250             


Glu Ser  Glu Ser Lys Asn Cys  Thr Ser Glu Ile Arg  Lys Tyr Gln 
    2255                 2260                 2265             


Glu Trp  Ser Arg Lys Arg Ser  Ile Gln Trp Glu Ala  Ile Ser Glu 
    2270                 2275                 2280             


Arg Tyr  Lys Lys Tyr Lys Arg  Met Asp Glu Phe Lys  Asn Val Lys 
    2285                 2290                 2295             


Glu Pro  Asp Ala Asn Glu Tyr  Leu Lys Glu His Cys  Ser Lys Cys 
    2300                 2305                 2310             


Pro Cys  Gly Tyr Asn Asp Met  Glu Glu Ile Ala Asn  Asp Thr Glu 
    2315                 2320                 2325             


Asn Lys  Gln Asp Ile Phe Lys  Gln Ile Ile Glu Lys  Val Lys Ile 
    2330                 2335                 2340             


Pro Ala  Glu Leu Glu Asp Val  Ile Tyr Arg Leu Lys  His His Lys 
    2345                 2350                 2355             


Tyr Asn  Ser Asn Asp Tyr Ile  Cys Asn Lys Tyr Lys  Asn Ile Asn 
    2360                 2365                 2370             


Val Asn  Lys Arg His Lys Asn  Asp Asp Thr Trp Thr  Asp Leu Leu 
    2375                 2380                 2385             


Val Lys  Asn Ser Ser Asp Ile  Asn Lys Gly Val Leu  Ile Pro Pro 
    2390                 2395                 2400             


Arg Arg  Lys Asn Leu Phe Leu  Asn Ile Glu Lys Ser  Asp Ile Cys 
    2405                 2410                 2415             


Lys Tyr  Lys Lys Asp Pro Lys  Leu Phe Asn Asp Phe  Ile Tyr Ser 
    2420                 2425                 2430             


Ser Ala  Ile Ser Glu Val Glu  Arg Leu Lys Ile Val  Tyr Gly Glu 
    2435                 2440                 2445             


Ala Arg  Ala Lys Val Val His  Ala Met Lys Tyr Ser  Phe Ala Asp 
    2450                 2455                 2460             


Ile Gly  Asn Ile Ile Lys Gly  Asp Asp Met Met Asp  Lys Asp Thr 
    2465                 2470                 2475             


Ser Asp  Lys Ile Gly Lys Ile  Leu Gly Gly Asp Gly  Val Gly Gln 
    2480                 2485                 2490             


Asn Glu  Lys Arg Lys Lys Trp  Trp Asp Ser Asn Lys  Tyr His Ile 
    2495                 2500                 2505             


Trp Glu  Ser Met Leu Cys Ala  Tyr Lys Lys Ala Tyr  Arg Asn Ile 
    2510                 2515                 2520             


Ser Asp  Val Asp Lys Lys Met  Leu Asp Ile Pro Asn  Asn Asp Asn 
    2525                 2530                 2535             


Glu His  Gln Phe Leu Arg Trp  Phe Thr Glu Trp Gly  Glu Asp Phe 
    2540                 2545                 2550             


Cys Lys  Gln Arg Gly Ile Lys  Glu Glu Glu Leu Val  Lys Gly Cys 
    2555                 2560                 2565             


Lys Asp  Cys Gly Val Asp Val  His Gly Lys Ser Cys  Asn Gly Lys 
    2570                 2575                 2580             


Cys Gly  Glu Cys Lys Thr Gln  Cys Glu Glu Tyr Lys  Lys Trp Ile 
    2585                 2590                 2595             


Glu Thr  Trp Lys Glu Asn Tyr  Lys Lys Gln Asn Glu  Val Tyr Asn 
    2600                 2605                 2610             


Glu Val  Lys Lys Thr Glu Gln  Tyr Asn Lys Asp Ser  Asp Val Lys 
    2615                 2620                 2625             


Ala Ser  Asp Asp Ala Arg Val  Tyr Leu Asp Thr Gln  Leu Lys Asn 
    2630                 2635                 2640             


Met Met  Cys Thr Asn Glu Ser  Thr Tyr Lys Asn Cys  Asp Tyr Thr 
    2645                 2650                 2655             


Cys Met  Asn Glu Ser Ser Ser  Thr Ala Arg Gly Asp  Ser Met Pro 
    2660                 2665                 2670             


Lys Thr  Leu Asp Asp Val Pro  Glu Lys Val Lys Asp  Lys Cys Thr 
    2675                 2680                 2685             


Cys Ile  Pro Asp Glu Cys Asn  Ala Leu Ser Val Thr  Asn Ser Gly 
    2690                 2695                 2700             


Phe Pro  Asp Gly Ser Ala Phe  Gly Gly Gly Val Ser  Tyr Gly Lys 
    2705                 2710                 2715             


Cys Lys  Gly Leu Glu Gly Gly  Pro Pro Lys Lys Val  Glu Asn Pro 
    2720                 2725                 2730             


Pro Ser  Asp Tyr Thr Ser Asp  Ile Leu Thr Ser Thr  Ile Pro Val 
    2735                 2740                 2745             


Gly Ile  Ala Leu Ala Leu Gly  Ser Ile Ala Phe Leu  Phe Ile Lys 
    2750                 2755                 2760             


Lys Lys  Pro Lys Thr Pro Val  Asp Leu Leu Arg Val  Leu Asp Ile 
    2765                 2770                 2775             


His Lys  Gly Asp Tyr Gly Ile  Pro Thr Leu Lys Ser  Ser Asn Arg 
    2780                 2785                 2790             


Tyr Ile  Pro Tyr Val Ser Asp  Thr Tyr Lys Gly Lys  Thr Tyr Ile 
    2795                 2800                 2805             


Tyr Met  Glu Gly Asp Thr Ser  Gly Asp Asp Asp Lys  Tyr Ile Trp 
    2810                 2815                 2820             


Asp Leu  Ser Ser Ser Asp Ile  Thr Ser Ser Glu Ser  Glu Tyr Glu 
    2825                 2830                 2835             


Glu Leu  Asp Ile Asn Asp Ile  Tyr Val Pro Ser Leu  Pro Lys Tyr 
    2840                 2845                 2850             


Lys Thr  Leu Ile Glu Val Val  Leu Glu Pro Ser Lys  Arg Asp Thr 
    2855                 2860                 2865             


Phe Asn  Thr Pro Ser Gly Asp  Thr Phe Thr Asn Lys  Leu Thr Asp 
    2870                 2875                 2880             


Asp Glu  Trp Asn Gln Leu Lys  Gln Asp Phe Ile Glu  Gln Tyr Leu 
    2885                 2890                 2895             


Gln Asn  Ile Gln Lys Asp Phe  Ile Leu His Asp Ser  Val Asn Glu 
    2900                 2905                 2910             


Lys Pro  Phe Ile Thr Gln Ile  Gln Asp Arg Phe Leu  Asp Ser Ser 
    2915                 2920                 2925             


His Glu  Glu Val Ile Tyr Asn  Ile Asp Trp Asn Val  Pro Glu Asn 
    2930                 2935                 2940             


Ile Asn  Arg Ile Thr Asn Ile  Met Asp Asp Pro Lys  Tyr Ser Ser 
    2945                 2950                 2955             


Asn Asn  Met Tyr Thr Gly Thr  Asp Leu Ile Asn Asp  Ser Leu Asn 
    2960                 2965                 2970             


Gly Asn  Gln His Met Asp Ile  Tyr Asp Glu Met Leu  Lys Arg Lys 
    2975                 2980                 2985             


Glu Asn  Glu Leu Phe Gly Thr  Asn Asn Thr Lys Asn  Thr Thr Phe 
    2990                 2995                 3000             


Asn Ser  Val Tyr Lys Gln Thr  His Ser Asp Pro Ile  Ile Asn Gln 
    3005                 3010                 3015             


Leu Asn  Leu Tyr His Lys Trp  Leu Asp Lys His Arg  Asp Ile Cys 
    3020                 3025                 3030             


Glu Gln  Trp Lys Thr Lys Lys  Asp Met Leu Tyr Lys  Leu Asn Glu 
    3035                 3040                 3045             


Val Trp  Asn Met Glu Arg Lys  Glu Tyr Leu Leu Asp  Ile Pro Pro 
    3050                 3055                 3060             


Ser Ile  Leu Asp Asp Ile His  Lys Thr Asn Asp Glu  Thr Tyr Asn 
    3065                 3070                 3075             


Ile Ile  Ser Thr Asn Asn Ile  Tyr Asp His Pro Ser  Gln Glu Thr 
    3080                 3085                 3090             


Pro Leu  Gln Leu Leu Gly Ser  Thr Asn Ile Ile Pro  Ser Tyr Ile 
    3095                 3100                 3105             


Thr Thr  Glu Gln Asn Asn Gly  Leu Arg Thr Asn Ile  Ser Met Asp 
    3110                 3115                 3120             


Ile His  Ile Asp Glu Lys Asn  Tyr Asn Asn Val Val  Ala Thr Ser 
    3125                 3130                 3135             


Ile Ile  Gly Asp Asp Gln Met  Glu Asn Ser Tyr Asn  Cys 
    3140                 3145                 3150     


<210>  62
<211>  3113
<212>  PRT
<213>  Plasmodium falciparum

<400>  62

Met Asp Lys Ser Ser Ile Gly Asp Lys Ile Glu Ala Tyr Leu Glu Lys 
1               5                   10                  15      


Lys Ser Asn Glu Ser Asp Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys Asn 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Ile Asp Glu Trp Lys 
65                  70                  75                  80  


Cys Gln Gln Asn Ser Ser Asp Gly Ser Gly Lys Pro Glu Asn Ile Cys 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
            100                 105                 110         


Lys Phe Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
                165                 170                 175     


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Leu Glu Lys 
            180                 185                 190         


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Thr Lys 
        195                 200                 205             


Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
    210                 215                 220                 


Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Arg Trp 
225                 230                 235                 240 


Thr Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
                245                 250                 255     


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Tyr Leu Asp Tyr Val 
            260                 265                 270         


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Ala Asp Leu Tyr Arg 
        275                 280                 285             


Glu Lys Gln Asn Leu Ile Asp Gly Met Glu Arg His Arg Glu Glu Cys 
    290                 295                 300                 


Thr Arg Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Asn Met 
305                 310                 315                 320 


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
                325                 330                 335     


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Lys Asp Leu Tyr Glu Gln 
            340                 345                 350         


Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
        355                 360                 365             


Val Lys Glu Phe Phe Lys Lys Leu Glu Ala Asn Tyr Lys Ser Leu Asp 
    370                 375                 380                 


Asp Tyr Ile Lys Asp Asp Pro Tyr Ser Lys Glu Tyr Val Thr Lys Leu 
385                 390                 395                 400 


Ser Phe Ile Pro Asn Ser Ser Asp Thr Glu Asn Ala Ser Glu Lys Ile 
                405                 410                 415     


Gln Lys Asn Asn Asp Glu Val Cys Asn Pro Asn Glu Ser Gly Ile Ser 
            420                 425                 430         


Ser Val Gly Gln Ala Gln Thr Ser Gly Thr Ser Ser Asn Lys Thr Cys 
        435                 440                 445             


Ile Thr His Ser Ser Ile Lys Thr Asn Lys Lys Lys Val Cys Lys His 
    450                 455                 460                 


Val Lys Leu Gly Ile Asn Asn Asn Asp Lys Val Leu Arg Val Cys Val 
465                 470                 475                 480 


Ile Glu Asp Asp Ser Leu Arg Gly Val Asp Asn Cys Cys Cys Gln Asp 
                485                 490                 495     


Phe Leu Arg Met Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg Gly Ser 
            500                 505                 510         


Ser Ser Asn Asp Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
        515                 520                 525             


Asn Leu Asp Glu Ala Leu Ala Ser Leu Thr Asn Gly Tyr Lys Cys Asp 
    530                 535                 540                 


Lys Cys Lys Ser Gly Thr Ser Thr Val Asn Lys Asn Trp Ile Trp Arg 
545                 550                 555                 560 


Lys Ser Ser Gly Asn Lys Glu Gly Leu Gln Lys Glu Tyr Ala Asn Thr 
                565                 570                 575     


Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Cys Leu His 
            580                 585                 590         


Glu Lys Glu Gly Lys Thr Gln Glu Leu Lys Asn Ile Ser Thr Asn Ser 
        595                 600                 605             


Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly Lys Asn 
    610                 615                 620                 


Leu Lys Thr Thr Tyr Pro Gln Asn Lys Asn Ala Glu Asn Lys Lys Lys 
625                 630                 635                 640 


Leu Cys Lys Ala Leu Lys Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile 
                645                 650                 655     


Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu Leu 
            660                 665                 670         


Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys Lys 
        675                 680                 685             


Asn Asn Thr Ala Glu Gln His Thr Ser Tyr Ser Ser Leu Asp Glu Leu 
    690                 695                 700                 


Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Thr Ala Met 
705                 710                 715                 720 


Lys His Gly Ala Gly Met Asn Gly Thr Thr Cys Ser Ser Gly Ser Gly 
                725                 730                 735     


Asp Asn Gly Ser Ile Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu Ile 
            740                 745                 750         


Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe Cys Glu 
        755                 760                 765             


Gln Arg Gln Gly Lys Val Lys Asp Val Ile Thr Asn Cys Lys Ser Cys 
    770                 775                 780                 


Lys Glu Ser Gly Asp Thr Cys Lys Thr Glu Cys Lys Thr Lys Cys Lys 
785                 790                 795                 800 


Asp Glu Cys Glu Lys Tyr Lys Thr Phe Ile Glu Asp Cys Asn Gly Gly 
                805                 810                 815     


Gly Thr Gly Thr Ala Gly Ser Ser Trp Ser Lys Arg Trp Asp Gln Ile 
            820                 825                 830         


Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys 
        835                 840                 845             


Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Ser Thr Ala Glu 
    850                 855                 860                 


Ser Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile 
865                 870                 875                 880 


Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp 
                885                 890                 895     


Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr 
            900                 905                 910         


Tyr Thr Thr Thr Glu Asn Cys Asp Ile Gln Lys Lys Thr Pro Lys Ser 
        915                 920                 925             


Gln Ser Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly 
    930                 935                 940                 


Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Glu Cys Lys Ile Pro Thr 
945                 950                 955                 960 


Thr Glu Glu Ser Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp Ile 
                965                 970                 975     


Ser Asp Thr Ser Lys Lys Gln Lys Gly Ser Gly Ser Gly Lys Asp Asp 
            980                 985                 990         


Tyr Glu Leu Tyr Thr Tyr Asn Gly  Val Lys Glu Thr Lys  Leu Pro Lys 
        995                 1000                 1005             


Lys Leu  Asn Ser Thr Lys Leu  Asp Asp Lys Asp Val  Met Phe Phe 
    1010                 1015                 1020             


Asn Leu  Phe Glu Gln Trp Asn  Lys Glu Ile Gln Tyr  Gln Ile Glu 
    1025                 1030                 1035             


Gln Tyr  Met Thr Asn Ala Asn  Ile Ser Cys Asn Asn  Glu Met Asn 
    1040                 1045                 1050             


Val Leu  Ser Ser Ser Ser Glu  Glu Ser Gln Asn Gln  Lys Gly Ser 
    1055                 1060                 1065             


Asp His  His Val Gly Arg Asn  Asn Asn Thr Asp Gln  Gly Thr Asn 
    1070                 1075                 1080             


Cys Arg  Glu Lys Cys Glu Cys  Tyr Ser Leu Trp Ile  Glu Lys Ile 
    1085                 1090                 1095             


Lys Lys  Gln Trp Gly Lys Gln  Lys Asp Asn Tyr Asn  Lys Phe Gln 
    1100                 1105                 1110             


Arg Lys  Gln Ile Tyr Asp Gly  Asn Asn Ala Ser His  Lys Lys Glu 
    1115                 1120                 1125             


Ile Val  Lys Leu Ser Asn Phe  Leu Phe Phe Ser Cys  Trp Glu Glu 
    1130                 1135                 1140             


Tyr Ile  Gln Lys Tyr Phe Asn  Gly Asp Trp Ser Lys  Ile Lys Asn 
    1145                 1150                 1155             


Ile Gly  Ser Asp Thr Phe Glu  Phe Leu Ile Lys Lys  Cys Gly Asn 
    1160                 1165                 1170             


Asp Ser  Ala His Gly Glu Thr  Ile Phe Ser Glu Lys  Leu Lys Asn 
    1175                 1180                 1185             


Ala Gln  Gln Gln Cys Lys Glu  Ile Gln Asn Thr Asp  Thr Asn Ile 
    1190                 1195                 1200             


Asn Lys  Ser Gly Lys Ser Cys  Asp Leu Asn Ala Thr  Asn Tyr Ile 
    1205                 1210                 1215             


Arg Gly  Cys Gln Ser Lys Thr  Tyr Asp Gly Lys Ile  Phe Pro Gly 
    1220                 1225                 1230             


Lys Gly  Gly Glu Lys Gln Trp  Ile Cys Lys Asp Thr  Ile Ile His 
    1235                 1240                 1245             


Gly Asp  Thr Asn Gly Ala Cys  Ile Pro Pro Arg Thr  Gln Asn Leu 
    1250                 1255                 1260             


Cys Val  Gly Asn Leu Trp Asp  Lys Ser Tyr Gly Gly  Arg Ser Asn 
    1265                 1270                 1275             


Ile Lys  Asn Asp Thr Lys Glu  Ser Leu Lys Asn Lys  Leu Lys Asn 
    1280                 1285                 1290             


Ala Ile  Gln Lys Glu Thr Glu  Leu Leu Tyr Glu Tyr  His Asp Lys 
    1295                 1300                 1305             


Gly Thr  Ala Ile Ile Ser Gln  Asn Asp Lys Lys Gly  Glu Lys Gly 
    1310                 1315                 1320             


Lys Asn  Asp Pro Asn Gly Leu  Pro Lys Gly Phe Cys  His Ala Val 
    1325                 1330                 1335             


Gln Arg  Ser Phe Ile Asp Tyr  Lys Asn Met Ile Leu  Gly Thr Ser 
    1340                 1345                 1350             


Val Asn  Ile Tyr Glu Tyr Ile  Gly Lys Leu Gln Glu  Asp Ile Lys 
    1355                 1360                 1365             


Lys Ile  Ile Glu Gln Glu Arg  Thr Lys Thr Lys Glu  Lys Arg Val 
    1370                 1375                 1380             


Gly Ser  Gly Ala Glu Asn Val  Asn Ala Trp Trp Lys  Glu Ile Glu 
    1385                 1390                 1395             


Lys Asp  Met Trp Gly Ala Val  Lys Cys Gly Ile Lys  Thr Ile Lys 
    1400                 1405                 1410             


Lys Gln  Lys Lys Asn Gly Thr  Phe Asn Gly Asp Glu  Cys Gly Val 
    1415                 1420                 1425             


Ser Pro  Pro Thr Gly Asn Asp  Glu Asp Gln Phe Val  Ser Trp Phe 
    1430                 1435                 1440             


Lys Glu  Trp Gly Glu Gln Phe  Cys Ile Glu Arg Leu  Arg Tyr Glu 
    1445                 1450                 1455             


Gln Asn  Ile Arg Glu Ala Cys  Thr Ile Asn Gly Lys  Asn Gly Lys 
    1460                 1465                 1470             


Lys Cys  Ile Asn Ser Lys Ser  Gly Gln Gly Asp Lys  Ile Gln Gly 
    1475                 1480                 1485             


Asp Cys  Lys Arg Lys Cys Glu  Lys Tyr Lys Lys Tyr  Ile Ser Glu 
    1490                 1495                 1500             


Lys Lys  Gln Glu Trp Asp Lys  Gln Lys Thr Lys Tyr  Glu Asn Lys 
    1505                 1510                 1515             


Tyr Val  Gly Lys Ser Ala Ser  Asp Leu Leu Lys Glu  Asn Tyr Pro 
    1520                 1525                 1530             


Glu Cys  Ile Ser Ala Asn Phe  Asp Phe Ile Phe Asn  Asp Asn Ile 
    1535                 1540                 1545             


Glu Tyr  Lys Thr Tyr Tyr Pro  Tyr Gly Asp Tyr Asn  Ser Ile Cys 
    1550                 1555                 1560             


Ser Cys  Glu Gln Val Lys Tyr  Tyr Lys Tyr Asn Asn  Ala Glu Lys 
    1565                 1570                 1575             


Lys Asn  Asn Lys Ser Leu Cys  His Glu Lys Gly Asn  Asp Arg Thr 
    1580                 1585                 1590             


Trp Ser  Lys Lys Tyr Ile Lys  Lys Leu Glu Asn Gly  Arg Ser Leu 
    1595                 1600                 1605             


Glu Gly  Val Tyr Val Pro Pro  Arg Arg Gln Gln Leu  Cys Leu Tyr 
    1610                 1615                 1620             


Glu Leu  Phe Pro Ile Ile Ile  Lys Lys Glu Lys Asp  Met Glu Asn 
    1625                 1630                 1635             


Val Lys  Lys Glu Leu Leu Glu  Thr Leu Gln Ile Val  Ala Glu Arg 
    1640                 1645                 1650             


Glu Ala  Tyr Tyr Leu Trp Lys  Gln Tyr Asn Pro Thr  Gly Lys Gly 
    1655                 1660                 1665             


Ile Asp  Asp Ala Asn Lys Lys  Ala Cys Cys Ala Ile  Arg Gly Ser 
    1670                 1675                 1680             


Phe Tyr  Asp Leu Glu Asp Ile  Ile Lys Gly Asn Asp  Leu Val His 
    1685                 1690                 1695             


Asp Glu  Tyr Thr Lys Tyr Ile  Asp Ser Lys Leu Asn  Glu Ile Phe 
    1700                 1705                 1710             


Gly Ser  Ser Asn Lys Asn Asp  Ile Asp Thr Lys Arg  Ala Arg Thr 
    1715                 1720                 1725             


Asp Trp  Trp Glu Asn Glu Thr  Phe Gln Val Ser Asn  Ile Thr Gly 
    1730                 1735                 1740             


Ala Asn  Lys Ser Asp Pro Lys  Thr Ile Arg Gln Leu  Val Trp Asp 
    1745                 1750                 1755             


Ala Met  Gln Ser Gly Val Arg  Tyr Ala Val Glu Glu  Lys Asn Glu 
    1760                 1765                 1770             


Asn Phe  Pro Pro Cys Met Gly  Val Glu His Ile Gly  Ile Ala Lys 
    1775                 1780                 1785             


Pro Gln  Phe Ile Arg Trp Leu  Glu Glu Trp Thr Asn  Glu Phe Cys 
    1790                 1795                 1800             


Glu Lys  Tyr Thr Lys Tyr Phe  Glu Asp Met Lys Ser  Asn Cys Asn 
    1805                 1810                 1815             


Arg Arg  Lys Gly Ala Asp Thr  Cys Gly Asp Asn Ser  Asn Ile Glu 
    1820                 1825                 1830             


Cys Lys  Arg Ala Cys Ala Asn  Tyr Thr Asn Trp Leu  Asn Pro Lys 
    1835                 1840                 1845             


Arg Ile  Glu Trp Asn Gly Met  Ser Asn Tyr Tyr Asn  Lys Ile Tyr 
    1850                 1855                 1860             


Arg Lys  Ser Asn Lys Glu Ser  Glu Asp Gly Lys Asp  Tyr Ser Met 
    1865                 1870                 1875             


Ile Met  Glu Pro Thr Val Ile  Asp Tyr Leu Asn Lys  Arg Cys His 
    1880                 1885                 1890             


Gly Glu  Ile Asn Gly Asn Tyr  Ile Cys Cys Ser Cys  Lys Asn Ile 
    1895                 1900                 1905             


Gly Glu  Tyr Asn Ser Thr Ser  Gly Thr Val Asn Lys  Lys Leu Gln 
    1910                 1915                 1920             


Lys Lys  Glu Thr Glu Cys Glu  Glu Glu Lys Gly Pro  Leu Asp Leu 
    1925                 1930                 1935             


Met Asn  Glu Val Leu Asn Lys  Met Asp Glu Lys Tyr  Ser Ala His 
    1940                 1945                 1950             


Lys Met  Lys Cys Thr Glu Val  Tyr Leu Glu His Val  Glu Glu Gln 
    1955                 1960                 1965             


Leu Lys  Glu Ile Asp Asn Ala  Ile Lys Asp Tyr Gln  Leu Tyr Pro 
    1970                 1975                 1980             


Leu Asp  Arg Cys Phe Asp Asp  Gln Thr Lys Met Lys  Val Cys Asn 
    1985                 1990                 1995             


Leu Ile  Gly Asp Ala Ile Gly  Cys Lys Asp Lys Thr  Lys Leu Asp 
    2000                 2005                 2010             


Glu Leu  Asp Glu Trp Asn Asp  Met Asp Leu Arg Asp  Pro Tyr Asn 
    2015                 2020                 2025             


Lys Tyr  Lys Gly Val Leu Ile  Pro Pro Arg Arg Arg  Gln Leu Cys 
    2030                 2035                 2040             


Phe Ser  Arg Ile Val Arg Gly  Pro Ala Asn Leu Arg  Asn Leu Asn 
    2045                 2050                 2055             


Glu Phe  Lys Glu Glu Ile Leu  Lys Gly Ala Leu Ser  Glu Gly Lys 
    2060                 2065                 2070             


Phe Leu  Gly Asn Tyr Tyr Lys  Glu His Lys Asp Lys  Glu Lys Ala 
    2075                 2080                 2085             


Leu Glu  Ala Met Lys Asn Ser  Phe Tyr Asp Tyr Glu  Asp Ile Ile 
    2090                 2095                 2100             


Lys Gly  Ser Asp Met Leu Ala  Asn Ile Lys Phe Lys  Asp Ile Lys 
    2105                 2110                 2115             


Ile Lys  Leu Asp Lys Leu Leu  Thr Lys Glu Thr Asn  Asn Thr Lys 
    2120                 2125                 2130             


Lys Ala  Glu Asp Trp Trp Glu  Thr Asn Lys Lys Ser  Ile Trp Asn 
    2135                 2140                 2145             


Ala Met  Leu Cys Gly Tyr Lys  Lys Ser Gly Asn Lys  Ile Ile Asp 
    2150                 2155                 2160             


Pro Ser  Trp Cys Lys Ile Ile  Thr Thr Glu Lys Thr  Pro Gln Phe 
    2165                 2170                 2175             


Leu Arg  Trp Ile Lys Glu Trp  Gly Thr Asn Val Cys  Ile Gln Lys 
    2180                 2185                 2190             


Glu Lys  Tyr Lys Lys Asn Val  Lys Ser Lys Cys Ser  Asn Val Pro 
    2195                 2200                 2205             


Asn Asn  Asn Leu Gly Ser Gln  Glu Ser Glu Ser Lys  Asn Cys Thr 
    2210                 2215                 2220             


Ser Glu  Ile Arg Lys Tyr Gln  Glu Trp Ser Arg Lys  Arg Ser Ile 
    2225                 2230                 2235             


Gln Trp  Glu Ala Ile Ser Glu  Gly Tyr Lys Lys Tyr  Lys Gly Lys 
    2240                 2245                 2250             


Asp Glu  Phe Lys Asn Val Lys  Glu Pro Asp Ala Asn  Thr Tyr Leu 
    2255                 2260                 2265             


Lys Glu  His Cys Ser Lys Cys  Pro Cys Gly Phe Asn  Asp Met Glu 
    2270                 2275                 2280             


Glu Ile  Ala Asn Asp Thr Glu  Asn Lys Gln Asp Ile  Phe Lys Gln 
    2285                 2290                 2295             


Ile Lys  Glu Gln Val Asp Ile  Pro Asp Glu Leu Glu  Asp Val Ile 
    2300                 2305                 2310             


Tyr Arg  Ile Lys Asn Arg Lys  Tyr Asn Ser Asn Asp  Tyr Ile Cys 
    2315                 2320                 2325             


Asn Lys  Tyr Lys Asn Ile Asn  Val Asn Lys Arg His  Lys Asn Asp 
    2330                 2335                 2340             


Asp Thr  Trp Thr Asp Leu Leu  Val Lys Asn Ser Ser  Asp Ile Asn 
    2345                 2350                 2355             


Lys Gly  Val Leu Ile Pro Pro  Arg Arg Lys Asn Leu  Phe Leu Asn 
    2360                 2365                 2370             


Ile Glu  Lys Ser Asp Ile Cys  Lys Tyr Lys Lys Asp  Pro Lys Leu 
    2375                 2380                 2385             


Phe Asn  Asp Phe Ile Tyr Ser  Ser Ala Ile Ser Glu  Val Glu Arg 
    2390                 2395                 2400             


Leu Lys  Ile Val Tyr Gly Glu  Ala Arg Ala Lys Val  Val His Ala 
    2405                 2410                 2415             


Met Lys  Tyr Ser Phe Ala Asp  Ile Gly Asn Ile Ile  Lys Gly Asp 
    2420                 2425                 2430             


Asp Met  Met Asp Lys Asp Thr  Ser Asp Lys Ile Gly  Lys Ile Leu 
    2435                 2440                 2445             


Gly Gly  Asp Gly Val Gly Gln  Asn Glu Lys Arg Lys  Lys Trp Trp 
    2450                 2455                 2460             


Asp Ser  Asn Lys Tyr His Ile  Trp Glu Ser Met Leu  Cys Ala Tyr 
    2465                 2470                 2475             


Lys Lys  Ala Tyr Arg Asn Ile  Ser Asp Val Asp Lys  Lys Met Leu 
    2480                 2485                 2490             


Asp Ile  Pro Asn Asn Asp Asn  Glu His Gln Phe Leu  Arg Trp Phe 
    2495                 2500                 2505             


Thr Glu  Trp Gly Glu Asp Phe  Cys Lys Gln Arg Gly  Ile Lys Glu 
    2510                 2515                 2520             


Glu Glu  Leu Val Lys Gly Cys  Lys Asp Cys Gly Val  Asp Val His 
    2525                 2530                 2535             


Gly Lys  Ser Cys Asn Gly Lys  Cys Gly Glu Cys Lys  Thr Gln Cys 
    2540                 2545                 2550             


Glu Glu  Tyr Lys Lys Trp Ile  Glu Thr Trp Lys Glu  Asn Tyr Lys 
    2555                 2560                 2565             


Lys Gln  Asn Glu Val Tyr Asn  Glu Val Lys Lys Thr  Glu Gln Tyr 
    2570                 2575                 2580             


Asn Lys  Asp Ser Asp Val Lys  Ala Ser Asp Asp Ala  Arg Val Tyr 
    2585                 2590                 2595             


Leu Asp  Thr Gln Leu Lys Asn  Met Met Cys Thr Asn  Glu Ser Thr 
    2600                 2605                 2610             


Tyr Lys  Asn Cys Asp Tyr Thr  Cys Met Asn Glu Ser  Ser Ser Thr 
    2615                 2620                 2625             


Ala Arg  Gly Asp Ser Met Pro  Lys Thr Leu Asp Asp  Val Pro Glu 
    2630                 2635                 2640             


Lys Val  Lys Asp Lys Cys Ile  Cys Ile Pro Asp Glu  Cys Asn Ala 
    2645                 2650                 2655             


Leu Ser  Val Thr Asn Ser Gly  Phe Pro Asp Gly Ser  Ala Phe Gly 
    2660                 2665                 2670             


Gly Gly  Val Ser Tyr Gly Lys  Cys Lys Gly Leu Glu  Gly Gly Pro 
    2675                 2680                 2685             


Pro Lys  Lys Val Glu Asn Pro  Pro Ser Asp Tyr Thr  Ser Asp Ile 
    2690                 2695                 2700             


Leu Thr  Ser Thr Ile Pro Val  Gly Ile Ala Leu Ala  Leu Gly Ser 
    2705                 2710                 2715             


Ile Ala  Phe Leu Phe Ile Lys  Lys Lys Pro Lys Thr  Pro Val Asp 
    2720                 2725                 2730             


Leu Leu  Arg Val Leu Asp Ile  His Lys Gly Asp Tyr  Gly Ile Pro 
    2735                 2740                 2745             


Thr Leu  Lys Ser Ser Asn Arg  Tyr Ile Pro Tyr Val  Ser Asp Thr 
    2750                 2755                 2760             


Tyr Lys  Gly Lys Thr Tyr Ile  Tyr Met Glu Gly Asp  Thr Ser Gly 
    2765                 2770                 2775             


Asp Asp  Asp Lys Tyr Ile Trp  Asp Leu Ser Ser Ser  Asp Ile Thr 
    2780                 2785                 2790             


Ser Ser  Glu Ser Glu Tyr Glu  Glu Leu Asp Ile Asn  Asp Ile Tyr 
    2795                 2800                 2805             


Val Pro  Ser Leu Pro Lys Tyr  Lys Thr Leu Ile Glu  Val Val Leu 
    2810                 2815                 2820             


Glu Pro  Ser Lys Arg Asp Thr  Phe Asn Thr Pro Ser  Gly Asp Thr 
    2825                 2830                 2835             


Phe Thr  Asn Lys Leu Thr Asp  Asp Glu Trp Asn Gln  Leu Lys Gln 
    2840                 2845                 2850             


Asp Phe  Ile Glu Gln Tyr Leu  Gln Asn Ile Gln Lys  Asp Phe Ile 
    2855                 2860                 2865             


Leu His  Asp Ser Val Asn Glu  Lys Pro Phe Ile Thr  Gln Ile Gln 
    2870                 2875                 2880             


Asp Arg  Phe Leu Asp Ser Ser  His Glu Glu Val Ile  Tyr Asn Ile 
    2885                 2890                 2895             


Asp Trp  Asn Val Pro Glu Asn  Ile Asn Arg Ile Asn  Asn Ile Met 
    2900                 2905                 2910             


His Asp  Thr Lys Tyr Cys Ser  Asn Asn Leu Tyr Thr  Gly Thr Asp 
    2915                 2920                 2925             


Leu Ile  Asn Asp Ser Leu Asn  Gly Asn Gln Tyr Ile  Asp Ile Tyr 
    2930                 2935                 2940             


Asp Glu  Met Leu Lys Arg Lys  Glu Asn Glu Leu Phe  Gly Thr Tyr 
    2945                 2950                 2955             


His Thr  Lys Tyr Thr Thr Phe  Asn Ser Val Ser Lys  Gln Thr Pro 
    2960                 2965                 2970             


Ser Asp  Pro Ile Ile Asn Gln  Leu Asp Leu Tyr His  Asn Trp Met 
    2975                 2980                 2985             


Asp Lys  His Arg Asp Ile Cys  Glu Gln Trp Lys Thr  Lys Glu Asp 
    2990                 2995                 3000             


Met Leu  Tyr Lys Leu Asn Glu  Val Trp Asn Met Glu  Arg Lys Glu 
    3005                 3010                 3015             


Tyr Leu  Leu Asp Ile Gln Pro  Ser Thr Leu Asp Asp  Ile His Lys 
    3020                 3025                 3030             


Ile Asn  Asp Glu Thr Tyr Asn  Ile Ile Ser Thr Asn  Asn Ile Tyr 
    3035                 3040                 3045             


Asp His  Pro Ser Gln Glu Thr  Pro Leu Gln Leu Leu  Gly Ser Thr 
    3050                 3055                 3060             


Asn Ile  Ile Pro Ser Tyr Ile  Thr Thr Glu Gln Asn  Asn Gly Leu 
    3065                 3070                 3075             


Arg Thr  Asn Ile Ser Met Asp  Thr Tyr Ile Asp Glu  Thr Asn Asn 
    3080                 3085                 3090             


Asn Asn  Val Val Ala Thr Ser  Ile Ile Gly Asp Asp  Gln Met Glu 
    3095                 3100                 3105             


Asn Ser  Tyr Asn Cys 
    3110             


<210>  63
<211>  3083
<212>  PRT
<213>  Plasmodium falciparum

<400>  63

Met Asp Lys Ser Ser Ile Ala Asn Lys Ile Glu Glu Tyr Leu Lys Glu 
1               5                   10                  15      


Lys Ser Asp Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro Ser 
            20                  25                  30          


Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys Asn 
        35                  40                  45              


Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
    50                  55                  60                  


Pro Cys Glu Lys Lys Leu Leu Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
65                  70                  75                  80  


Cys Asp Glu Asn Leu Ser Lys Val Ser Gly Lys Pro Glu Asn Ile Cys 
                85                  90                  95      


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
            100                 105                 110         


Lys Phe Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
        115                 120                 125             


Leu Thr Ala Arg Asn Glu Gly Glu Lys Ile Val Gln Asn His Pro Asp 
    130                 135                 140                 


Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala Asp 
145                 150                 155                 160 


Leu Ala Asp Ile Ile Arg Gly Arg Asp Gly Asn Lys Cys Glu Thr Lys 
                165                 170                 175     


Ser Pro Asn Asn Val Glu Glu Leu Ile Lys Lys Phe Phe Glu Lys Asn 
            180                 185                 190         


Tyr Arg Ser Asn Glu Glu Tyr Arg Lys Lys Tyr Pro Asn Asp Asp Glu 
        195                 200                 205             


Asn Tyr Lys Lys Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys 
    210                 215                 220                 


Val Trp Glu Val Ile Thr Cys Ser Ala Arg Ser Asn Asp Leu Leu Ile 
225                 230                 235                 240 


Lys Arg Arg Trp Arg Thr Ser Lys Glu Ser Asn Gly Glu Asn Lys Leu 
                245                 250                 255     


Glu Leu Cys Arg Lys Cys Gly His Tyr Glu Lys Glu Val Pro Thr Lys 
            260                 265                 270         


Leu Asp Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu 
        275                 280                 285             


Asp Phe Tyr Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His 
    290                 295                 300                 


Arg Glu Glu Cys Thr Arg Glu Asp Asp Lys Cys Lys Glu Gly Thr Ser 
305                 310                 315                 320 


Tyr Cys Asn Met Cys Lys Glu Lys His Thr Lys Tyr Cys Glu Cys Val 
                325                 330                 335     


Lys Lys Trp Lys Thr Glu Trp Glu Asn Gln Glu Asn Lys Tyr Thr Glu 
            340                 345                 350         


Leu Tyr Glu Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg 
        355                 360                 365             


Tyr Asp Asp Asn Val Lys Glu Phe Phe Glu Lys Leu Lys Gly Asn Gly 
    370                 375                 380                 


Tyr Ser Ser Ala Asn Ser Tyr Val Lys Asn Asn Pro Tyr Ser Ser Glu 
385                 390                 395                 400 


Asp Gly Lys Leu Leu Lys Phe Asp Asn Thr Asn Ala Phe Lys Glu Ser 
                405                 410                 415     


Ile Thr Cys Asn Lys Asn Val Cys Ser Cys Ser Gly Asn Glu Lys Leu 
            420                 425                 430         


Ile Ile Ser Glu Gly Ser Leu Ser Ser Ser Ser Phe Gly Thr Ser Ser 
        435                 440                 445             


Ser Tyr Gln Ser Ser Ile Ile Thr Ser Lys Lys Arg Asn Glu Cys Ala 
    450                 455                 460                 


Gln Ile Lys Phe Ser Gly Asn Glu Asn Asn Met Asn Ile Lys Ile Cys 
465                 470                 475                 480 


Ser Thr Gln Asp Asn Asn Leu Leu Val Lys Leu Glu Asp Leu Leu Lys 
                485                 490                 495     


Gly Phe Cys Asp Thr Cys Asp Thr Gly Ile Gly Val Glu Val Val Ser 
            500                 505                 510         


Glu Asn Asn Cys Glu Glu Gln Tyr Lys Lys Leu Leu Pro Ser Leu Glu 
        515                 520                 525             


Lys Cys Thr Val Leu Asn Cys Asn Glu Cys Asn Lys Thr Val Phe Lys 
    530                 535                 540                 


Asn Leu Lys Lys Gln Gln Glu Lys Trp Ile Trp Gly Lys Pro Lys Gln 
545                 550                 555                 560 


Glu Ala Ala Gly Leu Gln Glu Glu Tyr Ala Asn Thr Ile Gly Leu Pro 
                565                 570                 575     


Pro Arg Thr Gln Leu Leu Tyr Leu Val Cys Leu His Glu Lys Glu Gly 
            580                 585                 590         


Lys Thr Gln Glu Leu Lys Asn Ile Ser Thr Asn Ser Glu Leu Leu Lys 
        595                 600                 605             


Glu Trp Ile Ile Ala Ala Phe His Glu Gly Lys Asn Leu Lys Pro Ser 
    610                 615                 620                 


His Gln Asn Lys Asn Asp Asp Asn Gly Lys Lys Leu Cys Lys Asp Leu 
625                 630                 635                 640 


Lys Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile 
                645                 650                 655     


Trp Asp Asn Asp Phe Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ile 
            660                 665                 670         


Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys Lys Asn Ile Ser Thr Glu 
        675                 680                 685             


Gln Asp Thr Leu Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp 
    690                 695                 700                 


Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala Met Lys His Gly Ala Gly 
705                 710                 715                 720 


Met Asn Ser Thr Thr Cys Asn Gly Asp Gly Ser Val Thr Gly Ser Ser 
                725                 730                 735     


Asp Ser Gly Ser Thr Thr Cys Ser Gly Asp Asn Gly Ser Ile Ser Cys 
            740                 745                 750         


Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu 
        755                 760                 765             


Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg Gln Glu Lys Val Asn 
    770                 775                 780                 


Ala Val Ile Thr Asn Cys Lys Ser Cys Lys Asn Thr Ser Gly Glu Arg 
785                 790                 795                 800 


Lys Ile Gly Asp Thr Cys Gly Asn Asp Cys Glu Lys Lys Cys Lys Val 
                805                 810                 815     


Ala Cys Asp Ala Tyr Lys Glu Phe Ile Glu Glu Cys Arg Thr Ala Ala 
            820                 825                 830         


Glu Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln Ile Tyr 
        835                 840                 845             


Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala 
    850                 855                 860                 


Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala Glu Ser 
865                 870                 875                 880 


Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp 
                885                 890                 895     


Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp Glu 
            900                 905                 910         


Asn Asn Cys Gly Glu Asp Asn Ala Pro Trp Thr Thr Tyr Thr Thr Tyr 
        915                 920                 925             


Thr Thr Thr Lys Asn Cys Asp Ile Gln Lys Asp Lys Ser Lys Ser Gln 
    930                 935                 940                 


Ser Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
945                 950                 955                 960 


Thr Pro His Gly Tyr Lys Tyr Ala Cys Glu Cys Arg Thr Pro Asn Lys 
                965                 970                 975     


Gln Glu Thr Cys Asp Asp Arg Lys Glu Tyr Met Asn Gln Trp Ile Ile 
            980                 985                 990         


Asp Asn Thr Lys Asn Pro Lys Gly  Ser Gly Ser Gly Lys  Asp Tyr Tyr 
        995                 1000                 1005             


Glu Leu  Cys Lys Tyr Asn Gly  Val Lys Glu Thr Lys  Leu Pro Lys 
    1010                 1015                 1020             


Lys Leu  Asn Ser Ser Lys Leu  Asp Asp Lys Asp Val  Met Phe Phe 
    1025                 1030                 1035             


Asn Leu  Phe Glu Gln Trp Asn  Lys Glu Ile Gln Tyr  Gln Ile Glu 
    1040                 1045                 1050             


Gln Tyr  Met Thr Tyr Ala Asn  Ile Ser Cys Asn Asn  Glu Met Asn 
    1055                 1060                 1065             


Val Leu  Ser Ser Ser Ser Glu  Glu Ser Gln Asn Gln  Asn Gly Ser 
    1070                 1075                 1080             


Asp His  His Asp Gly Arg Asn  Asn Asn Thr Asp Gln  Gly Thr Asn 
    1085                 1090                 1095             


Cys Arg  Glu Lys Cys Lys Cys  Tyr Ser Leu Trp Ile  Glu Lys Ile 
    1100                 1105                 1110             


Lys Lys  Gln Trp Gly Lys Gln  Lys Asn Asn Tyr Asn  Lys Phe Glu 
    1115                 1120                 1125             


Lys Lys  Thr Ser Ser Tyr Ala  Asn Lys Gly Pro Gln  Asn Lys Lys 
    1130                 1135                 1140             


Val Val  Ser Leu Ser His Phe  Leu Phe Phe Ser Cys  Trp Glu Glu 
    1145                 1150                 1155             


Tyr Ile  Gln Lys Tyr Phe Asn  Gly Asp Trp Ser Lys  Ile Lys Asn 
    1160                 1165                 1170             


Ile Gly  Ser Asp Thr Phe Glu  Phe Leu Ile Lys Lys  Cys Gly Asn 
    1175                 1180                 1185             


Asp Ser  Ala His Gly Glu Thr  Ile Phe Ser Glu Lys  Leu Asn Asn 
    1190                 1195                 1200             


Ala His  Ile Lys Cys Asn Glu  Asn Ala Ser Lys Asn  Thr Lys Ile 
    1205                 1210                 1215             


Asn Pro  Ser Val Ile Ser Ser  Asp Cys Ser Glu Pro  Ile Tyr Ile 
    1220                 1225                 1230             


Arg Gly  Cys Gln Ser Lys Thr  Tyr Asp Gly Phe Ile  Ser Pro Gly 
    1235                 1240                 1245             


Lys Gly  Gly Glu Lys Gln Trp  Ile Cys Lys Asp Thr  Ile Thr His 
    1250                 1255                 1260             


Gly Asp  Thr Asn Gly Ala Cys  Ile Pro Pro Arg Thr  Gln Asn Leu 
    1265                 1270                 1275             


Cys Val  Gly Asn Leu Trp Asp  Lys Ser Tyr Gly Gly  Arg Ser Asn 
    1280                 1285                 1290             


Ile Lys  Asn Asp Thr Lys Glu  Ser Leu Lys Asn Lys  Leu Lys Asn 
    1295                 1300                 1305             


Ala Ile  Gln Lys Glu Thr Glu  Leu Leu Tyr Glu Tyr  His Asp Lys 
    1310                 1315                 1320             


Gly Thr  Ala Thr Ile Ser Arg  Asn Pro Met Lys Glu  Gly Gly Glu 
    1325                 1330                 1335             


Asp Gly  Lys Gly Lys Gln Lys  Glu Gly Gly Glu Lys  Ala Asn Asn 
    1340                 1345                 1350             


Asn Asn  Ser Asn Gly Leu Pro  Lys Gly Phe Cys His  Ala Val Gln 
    1355                 1360                 1365             


Arg Ser  Phe Ile Asp Tyr Lys  Asn Met Ile Leu Gly  Thr Ser Val 
    1370                 1375                 1380             


Asn Ile  Tyr Glu Tyr Ile Gly  Lys Leu Gln Glu Asp  Ile Lys Lys 
    1385                 1390                 1395             


Ile Ile  Glu Gln Glu Thr Pro  Gln Gln Asn Gly Lys  Thr Val Gly 
    1400                 1405                 1410             


Ser Gly  Ala Asp Lys Val Asn  Asp Trp Trp Lys Glu  Ile Glu Lys 
    1415                 1420                 1425             


Asp Met  Trp Gly Ala Val Lys  Cys Gly Ile Thr Lys  Ile Asn Lys 
    1430                 1435                 1440             


Lys Gln  Lys Lys Asn Gly Thr  Tyr Thr Gly Asp Glu  Cys Gly Val 
    1445                 1450                 1455             


Ser Pro  Pro Thr Gly Asn Asp  Glu Asp Gln Phe Val  Ser Trp Phe 
    1460                 1465                 1470             


Lys Glu  Trp Gly Glu Gln Phe  Cys Ile Glu Arg Leu  Gln Tyr Glu 
    1475                 1480                 1485             


Lys Asn  Ile Arg Asp Ala Cys  Thr Asn Asn Gly Gln  Gly Asp Lys 
    1490                 1495                 1500             


Ile Gln  Gly Ala Cys Lys Arg  Lys Cys Glu Lys Tyr  Lys Lys Tyr 
    1505                 1510                 1515             


Ile Ser  Glu Lys Lys Lys Glu  Trp Asp Lys Gln Lys  Thr Lys Tyr 
    1520                 1525                 1530             


Glu Asn  Lys Tyr Val Gly Lys  Ser Ala Ser Asp Leu  Leu Lys Glu 
    1535                 1540                 1545             


Asn Tyr  Pro Glu Cys Ile Ser  Ala Asn Phe Asp Phe  Ile Phe Asn 
    1550                 1555                 1560             


Asp Asn  Ile Glu Tyr Lys Thr  Tyr Tyr Pro Tyr Gly  Asp Tyr Ser 
    1565                 1570                 1575             


Ser Ile  Cys Ser Cys Glu Gln  Val Lys Tyr Tyr Lys  Tyr Asn Lys 
    1580                 1585                 1590             


Asp Lys  Gly Gln Asn Asn Lys  Ser Leu Cys His Glu  Lys Gly Asn 
    1595                 1600                 1605             


Asp Arg  Thr Trp Ser Lys Lys  Tyr Ile Lys Lys Leu  Glu Asn Gly 
    1610                 1615                 1620             


Arg Ser  Leu Glu Gly Val Tyr  Val Pro Pro Gly Arg  Gln Gln Leu 
    1625                 1630                 1635             


Cys Leu  Tyr Glu Leu Phe Pro  Ile Ile Ile Lys Asn  Glu Glu Gly 
    1640                 1645                 1650             


Met Glu  Lys Ala Lys Lys Glu  Leu Leu Glu Thr Leu  Gln Ile Val 
    1655                 1660                 1665             


Ala Glu  Arg Glu Ala Tyr Tyr  Leu Trp Lys Gln Tyr  His Ala His 
    1670                 1675                 1680             


Asn Asp  Thr Thr Tyr Leu Ala  His Lys Lys Ala Cys  Cys Ala Ile 
    1685                 1690                 1695             


Arg Gly  Ser Phe Tyr Asp Leu  Glu Asp Ile Ile Lys  Gly Asn Asp 
    1700                 1705                 1710             


Leu Val  His Asp Glu Tyr Thr  Lys Tyr Ile Asp Ser  Lys Leu Asn 
    1715                 1720                 1725             


Lys Ile  Phe Gly Ser Ser Asn  Thr Asn Asn Ile Glu  Thr Lys Arg 
    1730                 1735                 1740             


Ala Arg  Thr Asp Trp Trp Glu  Asn Lys Thr Ile Asp  Val Pro Asn 
    1745                 1750                 1755             


Ile Thr  Asp Ala Asn Lys Ser  Asp Ser Lys Thr Ile  Arg Gln Leu 
    1760                 1765                 1770             


Val Trp  Asp Ala Met Gln Ser  Gly Val Arg Lys Ala  Ile Asp Glu 
    1775                 1780                 1785             


Glu Asn  Glu Lys Lys Lys Pro  Asn Glu Asn Phe Pro  Pro Cys Met 
    1790                 1795                 1800             


Gly Val  Glu His Ile Gly Ile  Ala Lys Pro Gln Phe  Ile Arg Trp 
    1805                 1810                 1815             


Leu Glu  Glu Trp Thr Asn Glu  Phe Cys Glu Lys Tyr  Thr Lys Tyr 
    1820                 1825                 1830             


Phe Glu  Asp Met Lys Ser Asn  Cys Asp Pro Pro Lys  Ser Ala Asp 
    1835                 1840                 1845             


Asp Cys  Gly Asp Asn Thr Asn  Ile Glu Cys Lys Lys  Ala Cys Ala 
    1850                 1855                 1860             


Asn Tyr  Thr Asn Trp Leu Asn  Pro Lys Arg Ile Glu  Trp Asn Gly 
    1865                 1870                 1875             


Met Ser  Asn Tyr Tyr Asn Lys  Ile Tyr Arg Lys Ser  Asn Lys Glu 
    1880                 1885                 1890             


Ser Glu  Asp Gly Lys Asp Tyr  Ser Met Ile Met Glu  Pro Thr Val 
    1895                 1900                 1905             


Ile Asp  Tyr Leu Asn Lys Arg  Cys His Gly Glu Ile  Asn Gly Asn 
    1910                 1915                 1920             


Tyr Ile  Cys Cys Ser Cys Lys  Asn Ile Gly Ala Tyr  Asn Thr Thr 
    1925                 1930                 1935             


Ser Gly  Thr Val Asn Lys Lys  Leu Gln Lys Lys Glu  Thr Glu Cys 
    1940                 1945                 1950             


Glu Asp  Asn Lys Gly Pro Leu  Asp Leu Met Asn Glu  Val Leu Asn 
    1955                 1960                 1965             


Lys Met  Asp Pro Lys Tyr Ser  Lys Leu Asn Leu Lys  Cys Thr Glu 
    1970                 1975                 1980             


Val Tyr  Leu Glu His Val Glu  Glu Gln Leu Lys Glu  Ile Asp Asn 
    1985                 1990                 1995             


Ala Ile  Lys Asp Tyr Lys Leu  Tyr Pro Leu Asp Arg  Cys Phe Asp 
    2000                 2005                 2010             


Asp Gln  Thr Lys Met Lys Ile  Cys Asp Leu Ile Gly  Asp Ala Ile 
    2015                 2020                 2025             


Gly Cys  Lys Asp Lys Thr Lys  Leu Asp Glu Leu Asp  Glu Trp Asn 
    2030                 2035                 2040             


Asp Val  Asp Met Arg Asp Pro  Tyr Asn Lys His Lys  Gly Val Leu 
    2045                 2050                 2055             


Ile Pro  Pro Arg Arg Arg Gln  Leu Cys Phe Ser Arg  Ile Val Arg 
    2060                 2065                 2070             


Gly Arg  Ala Asn Leu Arg Asn  Leu Asn Glu Phe Lys  Glu Glu Ile 
    2075                 2080                 2085             


Leu Lys  Gly Ala Gln Ser Glu  Gly Lys Phe Leu Gly  Asn Tyr Tyr 
    2090                 2095                 2100             


Lys Glu  His Lys Gly Asn Tyr  Tyr Lys Glu His Lys  Asp Lys Glu 
    2105                 2110                 2115             


Lys Ala  Leu Glu Ala Met Lys  Asn Ser Phe Tyr Asp  Tyr Glu Tyr 
    2120                 2125                 2130             


Ile Ile  Lys Gly Ser Asp Ile  Leu Glu Asn Ile Gln  Phe Lys Asp 
    2135                 2140                 2145             


Ile Lys  Arg Lys Leu Asp Lys  Leu Leu Glu Lys Glu  Thr Asn Asn 
    2150                 2155                 2160             


Asn Ile  Gln Asn Ala Glu Asp  Trp Trp Lys Val Asn  Asn Lys Ser 
    2165                 2170                 2175             


Ile Trp  Asn Ala Met Leu Cys  Gly Tyr Lys Lys Ser  Gly Asn Lys 
    2180                 2185                 2190             


Ile Ile  Asp Pro Ser Trp Cys  Thr Ile Pro Thr Thr  Glu Lys Thr 
    2195                 2200                 2205             


Pro Gln  Phe Leu Arg Trp Ile  Lys Glu Trp Gly Thr  Asn Val Cys 
    2210                 2215                 2220             


Ile Gln  Lys Gln Glu His Lys  Glu Tyr Val Lys Ser  Lys Cys Ser 
    2225                 2230                 2235             


Asn Val  Thr Asn Asn Asn Leu  Gly Ser Gln Glu Ser  Glu Ser Lys 
    2240                 2245                 2250             


Asn Cys  Thr Ser Glu Ile Arg  Lys Tyr Gln Glu Trp  Ser Arg Lys 
    2255                 2260                 2265             


Arg Ser  Ile Gln Trp Glu Ala  Ile Ser Glu Arg Tyr  Lys Lys Tyr 
    2270                 2275                 2280             


Lys Gly  Met Asp Ile Leu Lys  Asp Val Lys Glu Pro  Asp Ala Asn 
    2285                 2290                 2295             


Thr Tyr  Leu Lys Glu His Cys  Ser Lys Cys Pro Cys  Gly Phe Asn 
    2300                 2305                 2310             


Asp Met  Lys Glu Ile Ser Asn  Asn Glu Asp Asn Glu  Lys Glu Thr 
    2315                 2320                 2325             


Phe Asn  Arg Ile Ile Glu Lys  Val Lys Ile Pro Ala  Glu Leu Glu 
    2330                 2335                 2340             


Asp Val  Ile Tyr Arg Leu Lys  His His Lys Tyr Asn  Ser Asn Asp 
    2345                 2350                 2355             


Tyr Ile  Cys Asn Lys Tyr Lys  Asn Ile Asn Val Asn  Met Lys Lys 
    2360                 2365                 2370             


Asn Asn  Asp Asn Ile Trp Thr  Asp Leu Val Lys Asn  Ser Trp Asp 
    2375                 2380                 2385             


Ile Asn  Lys Gly Val Leu Ile  Pro Pro Arg Arg Lys  Asn Leu Phe 
    2390                 2395                 2400             


Leu Lys  Ile Asp Glu Ser Asp  Ile Cys Lys Tyr Lys  Lys Asn Pro 
    2405                 2410                 2415             


Lys Leu  Phe Lys Asp Phe Ile  Tyr Ser Ser Ala Phe  Thr Glu Val 
    2420                 2425                 2430             


Glu Arg  Leu Lys Asn Ala Tyr  Gly Glu Ala Lys Thr  Lys Val Ala 
    2435                 2440                 2445             


Asn Ala  Met Lys Tyr Ser Phe  Ala Asp Ile Gly Asn  Ile Ile Lys 
    2450                 2455                 2460             


Gly Asp  Asp Met Met Glu Asn  Asn Ser Ser Asp Asn  Ile Gly Lys 
    2465                 2470                 2475             


Ile Leu  Gly Gly Asp Gly Asp  Arg Lys Asn Glu Lys  Arg Lys Lys 
    2480                 2485                 2490             


Trp Trp  Asp Met Asn Lys Tyr  His Val Trp Glu Ser  Met Leu Cys 
    2495                 2500                 2505             


Gly Tyr  Lys Gln Ala Gly Gly  Asp Thr Lys Thr Asn  Glu Asn Cys 
    2510                 2515                 2520             


Arg Phe  Pro Asp Thr Glu Ala  Val Pro Gln Phe Leu  Arg Trp Phe 
    2525                 2530                 2535             


Gln Glu  Trp Thr Glu Asn Phe  Cys Ile Arg Arg Asp  Glu Leu Tyr 
    2540                 2545                 2550             


Lys Lys  Ile Asp Thr Asn Cys  Thr Ser Ala Thr Cys  Asn Lys Glu 
    2555                 2560                 2565             


Asp Gly  Ser Val Asp Lys Lys  Glu Cys Thr Glu Ala  Cys Glu Lys 
    2570                 2575                 2580             


Tyr Gln  Asn Tyr Val Leu Ser  Lys Lys Thr Glu Tyr  Glu Ile Gln 
    2585                 2590                 2595             


Lys Lys  Lys Tyr Asp Thr Glu  Phe Lys Asn Lys Asn  Ser Asn Asp 
    2600                 2605                 2610             


Lys Asp  Ala Pro Asp Tyr Ile  Lys Asp Lys Cys Asn  Asn Asn Cys 
    2615                 2620                 2625             


Asp Cys  Ile Ser Tyr His Ile  Asp Asp Lys Lys Asn  Trp Lys Glu 
    2630                 2635                 2640             


Pro Tyr  Asp Thr Phe Asp Asp  Asp Lys Phe Lys Gly  Lys Cys Asp 
    2645                 2650                 2655             


Cys Pro  Lys Pro Leu Pro Leu  Phe Ser Asp Asn Thr  Ser Asp Ile 
    2660                 2665                 2670             


Leu Gln  Lys Thr Ile Pro Phe  Gly Ile Ala Leu Ala  Leu Gly Ser 
    2675                 2680                 2685             


Ile Ala  Phe Leu Phe Met Lys  Lys Lys Pro Lys Thr  Pro Val Asp 
    2690                 2695                 2700             


Leu Leu  Arg Val Leu Asp Ile  His Lys Gly Asp Tyr  Gly Ile Pro 
    2705                 2710                 2715             


Thr Thr  Lys Ser Ser Asn Arg  Tyr Ile Pro Tyr Val  Ser Asp Thr 
    2720                 2725                 2730             


Tyr Lys  Gly Lys Thr Tyr Ile  Tyr Met Glu Gly Asp  Thr Ser Gly 
    2735                 2740                 2745             


Asp Asp  Asp Lys Tyr Ile Trp  Asp Leu Ser Ser Ser  Asp Ile Thr 
    2750                 2755                 2760             


Ser Ser  Glu Ser Glu Tyr Glu  Glu Leu Asp Ile Asn  Asp Ile Tyr 
    2765                 2770                 2775             


Val Pro  Ser Leu Pro Lys Tyr  Lys Thr Leu Ile Glu  Val Val Leu 
    2780                 2785                 2790             


Glu Pro  Ser Lys Arg Asp Thr  Phe Asn Thr Ser Ser  Gly Asp Thr 
    2795                 2800                 2805             


Phe Thr  Asn Lys Leu Thr Asp  Asp Glu Trp Asn Gln  Leu Lys Gln 
    2810                 2815                 2820             


Asp Phe  Ile Glu Gln Tyr Leu  Gln Asn Ile Gln Lys  Asp Phe Ile 
    2825                 2830                 2835             


Leu His  Asp Ser Val Asn Glu  Lys Pro Phe Ile Thr  Gln Ile Gln 
    2840                 2845                 2850             


Asp Arg  Phe Leu Asp Ser Ser  His Glu Glu Val Ile  Tyr Asn Ile 
    2855                 2860                 2865             


Asp Trp  Asn Val Pro Glu Asn  Ile Asn Arg Ile Asn  Asn Ile Met 
    2870                 2875                 2880             


His Asp  Thr Lys Tyr Cys Ser  Asn Asn Leu Tyr Thr  Gly Thr Asp 
    2885                 2890                 2895             


Leu Ile  Asn Asp Ser Leu Asn  Gly Asn Gln His Met  Asp Ile Tyr 
    2900                 2905                 2910             


Asp Glu  Met Leu Lys Arg Lys  Glu Asn Glu Leu Phe  Gly Thr Asn 
    2915                 2920                 2925             


Asn Thr  Lys Asn Thr Thr Phe  Asn Ser Val Tyr Lys  Gln Thr His 
    2930                 2935                 2940             


Ser Asp  Pro Ile Ile Asn Gln  Leu Asn Leu Tyr His  Lys Trp Leu 
    2945                 2950                 2955             


Asp Lys  His Arg Asp Ile Cys  Glu Gln Cys Lys Thr  Lys Lys Asp 
    2960                 2965                 2970             


Met Leu  Tyr Lys Leu Asn Glu  Val Trp Asn Met Glu  Arg Lys Glu 
    2975                 2980                 2985             


Tyr Leu  Leu Asp Ile Pro Pro  Ser Ile Leu Asp Asp  Ile His Lys 
    2990                 2995                 3000             


Thr Asn  Asp Glu Thr Tyr Asn  Ile Ile Ser Thr Asn  Asn Ile Tyr 
    3005                 3010                 3015             


Asp His  Pro Ser Gln Glu Thr  Pro Leu Gln Leu Leu  Gly Ser Thr 
    3020                 3025                 3030             


Asn Ile  Ile Pro Ser Tyr Ile  Thr Thr Glu Gln Asn  Asn Gly Leu 
    3035                 3040                 3045             


Arg Thr  Asn Ile Ser Met Asp  Ile His Ile Asp Glu  Lys Asn Tyr 
    3050                 3055                 3060             


Asn Asn  Val Val Ala Thr Ser  Ile Ile Gly Asp Asp  Gln Met Glu 
    3065                 3070                 3075             


Asn Ser  Tyr Asn Cys 
    3080             


<210>  64
<211>  3105
<212>  PRT
<213>  Plasmodium falciparum

<400>  64

Met Asp Ser Thr Ser Thr Ile Ala Asp Lys Ile Glu Glu Tyr Leu Glu 
1               5                   10                  15      


Lys Lys Ser Asp Glu Ser Asn Ile Glu Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Glu Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Gly Asn His Lys Asn Ile 
                85                  90                  95      


Cys Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys 
            100                 105                 110         


Leu Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Arg Asp Glu Asn Lys Cys Glu Thr 
                165                 170                 175     


Lys Ser Thr Asn Asn Val Glu Glu Leu Ile Lys Asn Phe Phe Gly Lys 
            180                 185                 190         


Asn Tyr Arg Ser Asn Glu Glu Tyr Lys Arg Lys Tyr Arg Asn Asp Asp 
        195                 200                 205             


Pro Lys Tyr Thr Lys Leu Arg Glu Ser Trp Trp Thr Lys Asn Arg Gln 
    210                 215                 220                 


Lys Val Trp Glu Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu 
225                 230                 235                 240 


Ile Lys Arg Gly Trp Arg Thr Ser Lys Glu Ser Glu Gly Glu Asn Lys 
                245                 250                 255     


Leu Glu Leu Phe Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr 
            260                 265                 270         


Lys Leu Asp Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile 
        275                 280                 285             


Glu Asp Leu Tyr Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg 
    290                 295                 300                 


His Arg Glu Glu Cys Thr Ser Glu Asp Asp Lys Cys Lys Glu Val Thr 
305                 310                 315                 320 


Ser Tyr Cys Ser Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Phe 
                325                 330                 335     


Val Lys Lys Trp Lys Ser Glu Trp Lys Asn Gln Lys Asn Lys Tyr Thr 
            340                 345                 350         


Glu Leu Tyr Glu Gln Asn Lys Asn Lys Thr Ser Ser Ser Ser Lys Asn 
        355                 360                 365             


Thr Ser Arg Tyr Asp Asp Tyr Val Lys Glu Phe Phe Lys Lys Leu Asn 
    370                 375                 380                 


Glu Ala Asn Tyr Lys Ser Leu Asp Asp Tyr Ile Lys Gly Asp Pro Tyr 
385                 390                 395                 400 


Ser Ala Glu Tyr Val Thr Lys Leu Ser Phe Ile Leu Asn Pro Ser Asp 
                405                 410                 415     


Ala Asn Asn Pro Ser Gly Glu Thr Ala Asn His Asn Asp Glu Val Cys 
            420                 425                 430         


Asn Cys Asn Glu Ser Glu Ile Ala Cys Val Glu Leu Ala Gln Thr Ser 
        435                 440                 445             


Gly Ser Ser Ser Asn Lys Thr Cys Ile Thr His Ser Ser Ile Lys Ala 
    450                 455                 460                 


Asn Lys Lys Lys Val Cys Lys Asp Val Lys Leu Gly Ile Asn Asn Asn 
465                 470                 475                 480 


Asp Lys Asp Leu Lys Ile Cys Val Ile Glu Asp Thr Ser Leu Ser Gly 
                485                 490                 495     


Val Glu Asn Cys Cys Cys Gln Asp Phe Leu Arg Met Leu Gln Glu Asn 
            500                 505                 510         


Cys Ser Asp Asn Lys Ser Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn 
        515                 520                 525             


Asn Asn Glu Asp Glu Cys Gln Lys Lys Leu Glu Lys Val Phe Ala Ser 
    530                 535                 540                 


Leu Thr Asn Gly Tyr Lys Cys Asp Lys Cys Lys Ser Glu Gln Ser Lys 
545                 550                 555                 560 


Lys Asn Asn Asn Ile Trp Ile Trp Arg Lys Ser Ser Gly Asp Glu Lys 
                565                 570                 575     


Gly Leu Gln Lys Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr 
            580                 585                 590         


Gln Ser Leu Tyr Leu Gly Asn Leu Pro Lys Leu Glu Asn Val Cys Glu 
        595                 600                 605             


Asp Val Thr Asp Ile Asn Phe Asp Thr Lys Glu Lys Phe Leu Ala Gly 
    610                 615                 620                 


Cys Leu Ile Ala Ala Phe His Glu Gly Lys Asn Leu Lys Lys Arg Tyr 
625                 630                 635                 640 


His Gln Asn Lys Asn Asp Glu Asn Lys Lys Lys Leu Cys Lys Ala Leu 
                645                 650                 655     


Lys Tyr Ser Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile 
            660                 665                 670         


Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ile 
        675                 680                 685             


Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys Lys Asn Ile Ser Thr Glu 
    690                 695                 700                 


Gln Asp Thr Leu Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp 
705                 710                 715                 720 


Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala Met Lys His Gly Thr Thr 
                725                 730                 735     


Cys Ser Ser Gly Ser Gly Asp Asn Gly Asp Gly Ser Val Thr Gly Ser 
            740                 745                 750         


Ser Asp Ser Gly Ser Thr Thr Cys Cys Gly Asp Gly Ser Val Thr Gly 
        755                 760                 765             


Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln 
    770                 775                 780                 


Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg 
785                 790                 795                 800 


Gln Glu Lys Val Asn Ala Val Ile Asn Ser Cys Asn Ser Cys Lys Asn 
                805                 810                 815     


Thr Ser Ser Lys Thr Lys Leu Gly Asp Thr Cys Lys Thr Glu Cys Lys 
            820                 825                 830         


Asn Lys Cys Glu Ala Tyr Lys Asn Phe Ile Glu Asp Cys Lys Gly Gly 
        835                 840                 845             


Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Tyr Gln Ile Tyr 
    850                 855                 860                 


Met Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala 
865                 870                 875                 880 


Gly Thr Lys Ser Cys Gly Thr Ser Ser Gly Ala Thr Ser Gly Val Thr 
                885                 890                 895     


Thr Thr Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys 
            900                 905                 910         


His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile 
        915                 920                 925             


Val Leu Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr 
    930                 935                 940                 


Tyr Thr Thr Tyr Thr Thr Lys Asn Cys Asp Lys Asp Lys Lys Lys Ser 
945                 950                 955                 960 


Lys Ser Gln Ser Cys Asp Thr Leu Val Val Val Asn Val Pro Ser Pro 
                965                 970                 975     


Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Val Cys Glu Cys Arg Thr 
            980                 985                 990         


Pro Ser Asn Lys Glu Leu Cys Asp  Asp Arg Lys Glu Tyr  Met Asn Gln 
        995                 1000                 1005             


Trp Ile  Ser Asp Thr Ser Lys  Asn Pro Lys Gly Gly  Arg Ser Thr 
    1010                 1015                 1020             


Asn Asn  Asp Tyr Glu Leu Tyr  Thr Tyr Asn Gly Val  Asp Val Lys 
    1025                 1030                 1035             


Pro Thr  Thr Val Arg Ser Asn  Ser Thr Lys Leu Asp  Asp Lys Asp 
    1040                 1045                 1050             


Val Met  Phe Phe Asn Leu Phe  Glu Gln Trp Asn Lys  Glu Ile Gln 
    1055                 1060                 1065             


Tyr Gln  Ile Glu Gln Tyr Met  Thr Asn Thr Lys Ile  Ser Cys Asn 
    1070                 1075                 1080             


Asn Glu  Met Lys Val Leu Ser  Arg Val Ser Glu Glu  Ser Lys Asn 
    1085                 1090                 1095             


Gln Asn  Ser Ser Asp Asp His  Asp Gly Gly Asn Asn  Asn Thr Asp 
    1100                 1105                 1110             


Gln Gly  Thr Asn Cys Lys Glu  Lys Cys Glu Cys Tyr  Lys Leu Trp 
    1115                 1120                 1125             


Ile Glu  Lys Ile Lys Glu Gln  Trp Asp Lys Gln Lys  Lys Asn Tyr 
    1130                 1135                 1140             


Asn Lys  Phe Glu Lys Lys Thr  Ser Asn Asp Ala Arg  Lys Ser Ser 
    1145                 1150                 1155             


Gln Asn  Lys Lys Val Val Ser  Leu Ser His Phe Leu  Phe Phe Ser 
    1160                 1165                 1170             


Cys Trp  Glu Glu Tyr Ile Gln  Lys Tyr Phe Asn Gly  Asp Trp Ser 
    1175                 1180                 1185             


Lys Ile  Lys Asn Ile Gly Ser  Asp Thr Phe Glu Phe  Leu Ile Lys 
    1190                 1195                 1200             


Lys Cys  Gly Asn Asn Ser Gly  Asp Gly Glu Thr Ile  Phe Ser Glu 
    1205                 1210                 1215             


Lys Leu  Asn Asn Ala Asn Ile  Lys Cys Asn Glu Asn  Glu Ser Thr 
    1220                 1225                 1230             


Asp Thr  Lys Ile Asn Lys Ser  Glu Thr Ser Cys Asp  Leu Asn Ala 
    1235                 1240                 1245             


Thr Asn  Tyr Ile Arg Gly Cys  Gln Ser Lys Thr Tyr  Asp Gly Lys 
    1250                 1255                 1260             


Ile Phe  Pro Gly Lys Gly Gly  Glu Lys Gln Trp Ile  Cys Lys Asp 
    1265                 1270                 1275             


Thr Ile  Ile His Gly Asp Thr  Asn Gly Ala Cys Ile  Pro Pro Arg 
    1280                 1285                 1290             


Thr Gln  Asn Leu Cys Val Gly  Glu Leu Trp Asp Lys  Arg Tyr Gly 
    1295                 1300                 1305             


Gly Arg  Ser Asn Ile Lys Asn  Asp Thr Lys Glu Ser  Leu Lys Asn 
    1310                 1315                 1320             


Lys Leu  Lys Asn Ala Ile Gln  Lys Glu Thr Glu Leu  Leu Tyr Glu 
    1325                 1330                 1335             


Tyr His  Asp Lys Gly Thr Ala  Thr Ile Ser Arg Asn  Pro Met Lys 
    1340                 1345                 1350             


Glu Gly  Gly Glu Asp Gly Lys  Gly Lys Gln Lys Glu  Gly Gly Glu 
    1355                 1360                 1365             


Lys Ala  Asn Asn Asn Lys Asn  Ser Asn Gly Leu Pro  Lys Gly Phe 
    1370                 1375                 1380             


Cys His  Ala Val Gln Arg Ser  Phe Ile Asp Tyr Lys  Asn Met Ile 
    1385                 1390                 1395             


Leu Gly  Thr Ser Val Asn Ile  Tyr Glu Tyr Ile Gly  Lys Leu Gln 
    1400                 1405                 1410             


Glu Asp  Ile Lys Lys Ile Ile  Glu Lys Gly Thr Thr  Lys Gln Asn 
    1415                 1420                 1425             


Gly Lys  Thr Val Gly Ser Gly  Ala Asp Lys Val Asn  Asp Trp Trp 
    1430                 1435                 1440             


Lys Glu  Ile Glu Lys Asp Met  Trp Gly Ala Val Lys  Cys Gly Ile 
    1445                 1450                 1455             


Lys Thr  Ile Lys Lys Gln Asn  Asn Lys Cys Thr Tyr  Thr Gly Asp 
    1460                 1465                 1470             


Glu Cys  Gly Ile Phe Pro Pro  Thr Gly Asn Asp Glu  Asp Gln Phe 
    1475                 1480                 1485             


Val Ser  Trp Phe Lys Glu Trp  Gly Glu Gln Phe Cys  Ile Glu Arg 
    1490                 1495                 1500             


Leu Gln  Tyr Glu Gln Asn Ile  Arg Asp Ala Cys Ile  Asn Asn Gly 
    1505                 1510                 1515             


Lys Asn  Glu Lys Lys Cys Ile  Asn Ser Lys Ser Gly  Gln Gly Asp 
    1520                 1525                 1530             


Lys Val  Glu Gly Ala Cys Lys  Arg Lys Cys Glu Glu  Tyr Lys Lys 
    1535                 1540                 1545             


Tyr Ile  Ser Glu Lys Lys Lys  Glu Trp Asp Lys Gln  Lys Thr Lys 
    1550                 1555                 1560             


Tyr Glu  Asn Lys Tyr Val Gly  Lys Ser Ala Ser Asp  Leu Leu Lys 
    1565                 1570                 1575             


Glu Asn  Tyr Pro Glu Cys Ile  Ser Ala Asn Phe Asp  Phe Ile Phe 
    1580                 1585                 1590             


Asn Asp  Asn Ile Glu Tyr Lys  Thr Tyr Tyr Pro Tyr  Gly Asp Tyr 
    1595                 1600                 1605             


Ser Ser  Ile Cys Ser Cys Glu  Gln Val Lys Tyr Tyr  Glu Tyr Ile 
    1610                 1615                 1620             


Lys Asp  Lys Gly Gln Asn Asn  Lys Ser Leu Cys His  Glu Lys Gly 
    1625                 1630                 1635             


Asn Asp  Arg Thr Trp Ser Lys  Lys Tyr Ile Lys Lys  Leu Glu Asn 
    1640                 1645                 1650             


Gly Arg  Thr Leu Glu Gly Val  Tyr Val Pro Pro Arg  Arg Gln Gln 
    1655                 1660                 1665             


Leu Cys  Leu Tyr Glu Leu Phe  Pro Ile Ile Ile Lys  Lys Glu Asn 
    1670                 1675                 1680             


Asp Ile  Thr Asn Ala Lys Lys  Glu Leu Leu Glu Thr  Leu Gln Ile 
    1685                 1690                 1695             


Val Ala  Glu Arg Glu Ala Tyr  Tyr Leu Trp Lys Gln  Tyr Asn Pro 
    1700                 1705                 1710             


Thr Gly  Lys Gly Ile Asp Asp  Ala Asn Lys Lys Ala  His Lys Lys 
    1715                 1720                 1725             


Ala Cys  Cys Ala Ile Arg Gly  Ser Phe Tyr Asp Leu  Glu Asp Ile 
    1730                 1735                 1740             


Ile Lys  Gly Asn Asp Leu Val  His Asp Glu Tyr Thr  Lys Tyr Ile 
    1745                 1750                 1755             


Asp Ser  Lys Leu Asn Lys Ile  Phe Gly Ser Ser Asn  Thr Asn Asn 
    1760                 1765                 1770             


Ile Asp  Thr Lys Arg Ala Arg  Thr Asp Trp Trp Glu  Asn Glu Ile 
    1775                 1780                 1785             


Ile Thr  Asn Gly Thr Asp Ser  Lys Thr Ile Arg Gln  Leu Val Trp 
    1790                 1795                 1800             


Asp Ala  Met Gln Ser Gly Val  Arg Tyr Ala Val Glu  Glu Lys Asn 
    1805                 1810                 1815             


Glu Asn  Phe Pro Pro Cys Met  Gly Val Glu His Ile  Gly Ile Ala 
    1820                 1825                 1830             


Lys Pro  Gln Phe Ile Arg Trp  Leu Glu Glu Trp Thr  Asn Glu Phe 
    1835                 1840                 1845             


Cys Glu  Lys Tyr Thr Lys Tyr  Phe Glu Asp Met Lys  Ser Lys Cys 
    1850                 1855                 1860             


Asp Pro  Pro Lys Ser Ala Asp  Asp Cys Gly Asp Asn  Ser Asn Ile 
    1865                 1870                 1875             


Glu Cys  Lys Arg Ala Cys Ala  Asn Tyr Thr Asn Trp  Leu Asn Pro 
    1880                 1885                 1890             


Lys Arg  Ile Glu Trp Asn Gly  Met Ser Asn Tyr Tyr  Asn Lys Ile 
    1895                 1900                 1905             


Tyr Arg  Lys Ser Asn Lys Glu  Ser Glu Asp Gly Lys  Asp Tyr Ser 
    1910                 1915                 1920             


Met Ile  Met Glu Pro Thr Val  Ile Asp Tyr Leu Asn  Lys Arg Cys 
    1925                 1930                 1935             


Asn Gly  Glu Ile Asn Gly Asn  Tyr Ile Cys Cys Ser  Cys Lys Asn 
    1940                 1945                 1950             


Ile Gly  Glu Asn Ser Thr Ser  Pro Ala Gln Lys Thr  Lys Gly Ser 
    1955                 1960                 1965             


Lys Lys  Lys Asp Glu Gln Cys  Glu Asp Asn Lys Gly  Pro Leu Asp 
    1970                 1975                 1980             


Leu Met  Asn Glu Val Leu Asn  Lys Met Asp Glu Lys  Tyr Ser Glu 
    1985                 1990                 1995             


His Lys  Met Lys Cys Thr Glu  Val Tyr Leu Glu His  Val Glu Glu 
    2000                 2005                 2010             


Gln Leu  Lys Glu Ile Asp Asn  Ala Ile Lys Asp Tyr  Lys Leu Tyr 
    2015                 2020                 2025             


Pro Leu  Asp Arg Cys Phe Asp  Asp Gln Thr Lys Met  Lys Ile Cys 
    2030                 2035                 2040             


Asp Leu  Ile Gly Asp Ala Ile  Gly Cys Lys Asp Lys  Thr Lys Leu 
    2045                 2050                 2055             


Asp Glu  Leu Asp Glu Trp Asn  Asp Val Asp Met Arg  Asp Pro Tyr 
    2060                 2065                 2070             


Asn Lys  His Lys Gly Val Leu  Ile Pro Pro Arg Arg  Arg Gln Leu 
    2075                 2080                 2085             


Cys Phe  Ser Arg Ile Val Arg  Gly Pro Ala Asn Leu  Arg Asn Leu 
    2090                 2095                 2100             


Asn Glu  Phe Lys Glu Glu Ile  Leu Lys Gly Ala Gln  Ser Glu Gly 
    2105                 2110                 2115             


Lys Phe  Leu Gly Asn Tyr Tyr  Lys Glu Lys Lys Asp  Lys Glu Lys 
    2120                 2125                 2130             


Lys Glu  His Lys Asp Lys Glu  Lys Ala Leu Glu Ala  Met Lys Asn 
    2135                 2140                 2145             


Ser Phe  Tyr Asp Tyr Glu Tyr  Ile Ile Lys Gly Thr  Asp Ile Leu 
    2150                 2155                 2160             


Glu Asn  Ile Gln Phe Lys Asp  Ile Lys Arg Lys Leu  Asp Lys Leu 
    2165                 2170                 2175             


Leu Thr  Lys Glu Thr Asn Asn  Asn Ile Gln Asn Ala  Glu Asp Trp 
    2180                 2185                 2190             


Trp Lys  Val Asn Asn Lys Ser  Ile Trp Asn Ala Met  Leu Cys Gly 
    2195                 2200                 2205             


Tyr Lys  Lys Ser Gly Asn Lys  Ile Ile Asp Pro Ser  Trp Cys Thr 
    2210                 2215                 2220             


Ile Pro  Thr Thr Glu Lys Thr  Pro Gln Phe Leu Arg  Trp Ile Lys 
    2225                 2230                 2235             


Glu Trp  Gly Thr Asn Val Cys  Ile Gln Lys Gln Glu  His Lys Glu 
    2240                 2245                 2250             


Tyr Val  Lys Ser Lys Cys Ser  Asn Val Thr Asn Ile  Asp Leu Asp 
    2255                 2260                 2265             


Pro Gln  Ala Ser Glu Ser Lys  Asn Cys Thr Ser Glu  Ile Arg Lys 
    2270                 2275                 2280             


Tyr Gln  Glu Trp Ser Arg Lys  Arg Ser Ile Gln Trp  Glu Ala Ile 
    2285                 2290                 2295             


Ser Glu  Arg Tyr Lys Arg Met  Asp Ile Leu Lys Asp  Val Lys Glu 
    2300                 2305                 2310             


Ser Asp  Ala Asn Glu Tyr Leu  Lys Glu His Cys Ser  Lys Cys Pro 
    2315                 2320                 2325             


Cys Gly  Phe Asn Asp Met Lys  Glu Ile Ala Asn Asp  Thr Glu Asn 
    2330                 2335                 2340             


Lys Gln  Asp Ile Phe Lys Gln  Ile Lys Glu Gln Val  Asp Ile Pro 
    2345                 2350                 2355             


Ala Glu  Leu Glu Asp Val Ile  Tyr Arg Leu Lys His  Arg Lys Tyr 
    2360                 2365                 2370             


Asn Ser  Asn Asp Tyr Phe Cys  Arg Lys Tyr Asn Asn  Lys Asn Leu 
    2375                 2380                 2385             


Tyr Ser  Arg Met Gln His Asn  Ile Asp Thr Ile Trp  Thr Asp Leu 
    2390                 2395                 2400             


Leu Val  Lys Asn Ser Trp Glu  Ile Asn Lys Gly Val  Leu Ile Pro 
    2405                 2410                 2415             


Pro Arg  Arg Lys Asn Leu Phe  Leu Asn Ile Glu Lys  Ser Asp Ile 
    2420                 2425                 2430             


Cys Glu  Tyr Lys Lys Asp Pro  Lys Leu Phe Lys Asp  Phe Ile Tyr 
    2435                 2440                 2445             


Ser Ser  Ala Phe Thr Glu Val  Glu Arg Leu Lys Lys  Val Tyr Gly 
    2450                 2455                 2460             


Gly Ala  Arg Ala Lys Val Val  His Ala Met Lys Tyr  Ser Phe Ala 
    2465                 2470                 2475             


Asp Ile  Gly Asn Ile Ile Lys  Gly Asp Asp Met Met  Glu Asn Asn 
    2480                 2485                 2490             


Ser Ser  Asp Lys Ile Gly Lys  Ile Leu Gly Gly Asp  Gly Asp Arg 
    2495                 2500                 2505             


Lys Asn  Glu Lys Arg Lys Ala  Trp Trp Asp Met Asn  Lys Tyr His 
    2510                 2515                 2520             


Ile Trp  Glu Ser Met Leu Cys  Gly Tyr Lys Gln Ala  Gly Gly Asp 
    2525                 2530                 2535             


Thr Glu  Thr Asn Glu Asn Cys  Arg Phe Pro Asp Thr  Asp Gly Val 
    2540                 2545                 2550             


Pro Gln  Phe Leu Arg Trp Phe  Gln Glu Trp Ile Glu  Ser Phe Cys 
    2555                 2560                 2565             


Ser His  Arg Lys Lys Leu Tyr  Glu Glu Leu Asn Ser  Ala Cys Thr 
    2570                 2575                 2580             


Ser Ala  Glu Cys Asp Thr Thr  Asn Gly Thr Ile Gly  Asn Asn Cys 
    2585                 2590                 2595             


Thr Ile  Ala Cys Gln Glu Tyr  Ser Asn Tyr Ile Ser  Ser Lys Lys 
    2600                 2605                 2610             


Glu Glu  Tyr Gln Ser Leu Lys  Ser Tyr Tyr Asp Val  Asn Tyr Lys 
    2615                 2620                 2625             


Glu Thr  Lys Gly Lys Asn Lys  Glu Ala His Glu Phe  Phe Lys Asn 
    2630                 2635                 2640             


Lys Cys  Asn Asp Asn Lys Cys  Glu Cys Leu Asn Lys  His Ile Asp 
    2645                 2650                 2655             


Asp Lys  Lys Asn Trp Lys Glu  Pro Tyr Glu Thr Leu  Asp Asn Met 
    2660                 2665                 2670             


Lys Leu  Lys Gly Ile Cys Asp  Cys Pro Lys Pro Leu  Pro Leu Phe 
    2675                 2680                 2685             


Ser Asp  Asn Thr Ser Asp Ile  Leu Gln Lys Thr Ile  Pro Val Gly 
    2690                 2695                 2700             


Ile Ala  Leu Ala Leu Gly Ser  Ile Ala Phe Phe Phe  Met Lys Lys 
    2705                 2710                 2715             


Lys Pro  Lys Thr Pro Val Asp  Leu Leu Arg Val Leu  Asp Ile His 
    2720                 2725                 2730             


Lys Gly  Asp Tyr Gly Ile Pro  Thr Thr Lys Ser Ser  Asn Arg Tyr 
    2735                 2740                 2745             


Ile Pro  Tyr Val Ser Asp Thr  Tyr Lys Gly Lys Thr  Tyr Ile Tyr 
    2750                 2755                 2760             


Met Glu  Gly Glu Glu Thr Asp  Asp Tyr Ser Tyr Ile  Arg Asp Ile 
    2765                 2770                 2775             


Ser Ser  Ser Asp Ile Thr Ser  Ser Ser Glu Ser Glu  Tyr Glu Glu 
    2780                 2785                 2790             


Leu Asp  Ile Asn Asp Ile Tyr  Val Pro Ser Leu Pro  Lys Tyr Lys 
    2795                 2800                 2805             


Thr Leu  Ile Glu Val Val Leu  Glu Pro Ser Lys Arg  Asp Thr Phe 
    2810                 2815                 2820             


Asn Thr  Pro Ser Gly Asp Thr  Phe Thr Asn Lys Leu  Thr Asp Asp 
    2825                 2830                 2835             


Glu Trp  Asn Gln Leu Lys Gln  Asp Phe Ile Glu Gln  Tyr Leu Gln 
    2840                 2845                 2850             


Asn Ile  Gln Lys Asp Phe Ile  Leu His Asp Ser Val  Asn Glu Lys 
    2855                 2860                 2865             


Pro Phe  Ile Thr Gln Ile Gln  Asp Arg Phe Leu Asp  Ser Ser His 
    2870                 2875                 2880             


Glu Glu  Val Ile Tyr Asn Ile  Asp Trp Asn Val Pro  Glu Asn Ile 
    2885                 2890                 2895             


Asn Arg  Ile Thr Asn Asn Met  Asp Asp Pro Lys Tyr  Ser Ser Asn 
    2900                 2905                 2910             


Asn Met  Tyr Thr Gly Thr Asp  Leu Ile Asn Asp Ser  Leu Asn Gly 
    2915                 2920                 2925             


Asn Gln  Tyr Ile Asp Ile Tyr  Asp Glu Met Leu Lys  Arg Lys Glu 
    2930                 2935                 2940             


Asn Glu  Leu Phe Gly Thr Tyr  His Thr Lys Tyr Thr  Thr Phe Asn 
    2945                 2950                 2955             


Ser Val  Ser Lys Gln Thr Pro  Ser Asp Pro Ile Ile  Asn Gln Leu 
    2960                 2965                 2970             


Asp Leu  Tyr His Asn Trp Met  Asp Lys His Arg Asp  Ile Cys Glu 
    2975                 2980                 2985             


Gln Trp  Lys Thr Lys Glu Asp  Met Leu Tyr Lys Leu  Asn Glu Val 
    2990                 2995                 3000             


Trp Asn  Met Glu Arg Lys Glu  Tyr Leu Leu Asp Ile  Gln Pro Ser 
    3005                 3010                 3015             


Thr Leu  Asp Asp Ile His Lys  Ile Asn Asp Glu Thr  Tyr Asn Ile 
    3020                 3025                 3030             


Ile Ser  Thr Asn Asn Ile Tyr  Asp His Pro Ser Gln  Glu Thr Pro 
    3035                 3040                 3045             


Leu Gln  Leu Leu Gly Ser Thr  Asn Ile Ile Pro Ser  Tyr Ile Thr 
    3050                 3055                 3060             


Thr Glu  Gln Asn Asn Gly Leu  Arg Thr Asn Ile Ser  Met Asp Thr 
    3065                 3070                 3075             


Tyr Ile  Asp Glu Thr Asn Asn  Asn Asn Val Val Ala  Thr Ser Ile 
    3080                 3085                 3090             


Ile Gly  Asp Asp Gln Met Glu  Asn Ser Tyr Asn Cys  
    3095                 3100                 3105 


<210>  65
<211>  3075
<212>  PRT
<213>  Plasmodium falciparum

<400>  65

Met Asp Ser Thr Ser Thr Ile Gly Asp Lys Ile Glu Glu Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asn Glu Ser Asn Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Lys Val Gln Tyr Tyr Arg Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn 
    50                  55                  60                  


Asp Pro Cys Asp Arg Lys Glu Leu Ser Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Asn Asn Lys Asn Ile 
                85                  90                  95      


Phe Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Asn 
            100                 105                 110         


Leu Lys Phe Glu Arg Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Lys Ile Val Gln Asn His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Val Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Leu Ala Asp Ile Ile Arg Gly Thr Asp Gln Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Lys Lys Ile Leu Glu 
            180                 185                 190         


Lys Asp Ser Thr Leu Lys Asn Asn Tyr Ser Asn Asp Asp Glu Asn Tyr 
        195                 200                 205             


Lys Lys Leu Arg Glu Ala Trp Trp Asn Ala Asn Arg Gln Lys Val Trp 
    210                 215                 220                 


Glu Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg 
225                 230                 235                 240 


Arg Trp Thr Thr Ser Lys Glu Ser Asn Gly Glu Asn Lys Leu Glu Leu 
                245                 250                 255     


Cys Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp 
            260                 265                 270         


Tyr Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Leu 
        275                 280                 285             


Tyr Arg Glu Glu Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu 
    290                 295                 300                 


Glu Cys Thr Ser Glu Asp Asp Lys Ser Asn Glu Gly Thr Ser Tyr Cys 
305                 310                 315                 320 


Thr Asn Cys Lys Glu Lys His Thr Lys Tyr Cys Glu Cys Val Lys Lys 
                325                 330                 335     


Trp Lys Thr Glu Trp Glu Asn Gln Lys Asn Lys Tyr Asn Asp Leu Tyr 
            340                 345                 350         


Gln Gln Lys Lys Asn Glu Thr Ser Ser Ser Ser Lys Lys Lys Ser Arg 
        355                 360                 365             


Tyr Asp Asp Tyr Val Lys Asp Phe Phe Lys Lys Leu Lys Gly Asn Val 
    370                 375                 380                 


Tyr Ser Ser Ala Asn Ser Tyr Val Lys Asn Asp Pro Tyr Ser Lys Glu 
385                 390                 395                 400 


Tyr Val Thr Lys Leu Ser Phe Ile Leu Asn Pro Ser Asp Ala Asn Thr 
                405                 410                 415     


Ser Ser Gly Glu Thr Ala Asn His Asn Asp Glu Val Cys Asn Cys Asn 
            420                 425                 430         


Glu Ser Gly Ile Ala Cys Val Gly Gln Ala Gln Ile Ser Asp Arg Leu 
        435                 440                 445             


Ser Gln Lys Ala Cys Asn Thr His Ser Ser Ile Lys Thr Asn Lys Lys 
    450                 455                 460                 


Lys Glu Cys Lys His Val Lys Leu Gly Val Arg Glu Asn Asp Lys Val 
465                 470                 475                 480 


Leu Lys Ile Cys Val Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn 
                485                 490                 495     


Cys Cys Cys Gln Asp Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp 
            500                 505                 510         


Asn Ile Arg Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln 
        515                 520                 525             


Asp Glu Cys Glu Lys Asn Leu Asp Glu Ala Leu Ala Ser Leu Thr Asn 
    530                 535                 540                 


Cys Tyr Lys Cys Glu Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn 
545                 550                 555                 560 


Lys Asn Trp Ile Trp Lys Lys Tyr Ser Val Lys Glu Glu Gly Leu Gln 
                565                 570                 575     


Lys Glu Tyr Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu 
            580                 585                 590         


Tyr Leu Gly Asn Leu Arg Lys Leu Glu Asn Val Cys Lys Asp Val Thr 
        595                 600                 605             


Asp Ile Asn Phe Asp Thr Lys Glu Lys Phe Leu Ala Gly Cys Leu Ile 
    610                 615                 620                 


Ala Ala Phe His Glu Gly Lys Asn Leu Lys Thr Thr Tyr Leu Glu Lys 
625                 630                 635                 640 


Lys Asn Asp Asp Asn Gly Lys Lys Leu Cys Lys Ala Leu Lys Tyr Ser 
                645                 650                 655     


Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn 
            660                 665                 670         


Asp Phe Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ala Phe Gly Lys 
        675                 680                 685             


Leu Phe Arg Lys Tyr Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr 
    690                 695                 700                 


Ser Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn 
705                 710                 715                 720 


Lys Lys Tyr Ile Trp Thr Ala Met Lys His Gly Thr Thr Cys Ser Ser 
                725                 730                 735     


Gly Ser Gly Asp Asn Gly Ser Ile Ser Cys Asp Asp Met Pro Thr Ile 
            740                 745                 750         


Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His 
        755                 760                 765             


Phe Cys Lys Gln Arg Gln Glu Lys Val Asn Ala Val Ile Thr Asn Cys 
    770                 775                 780                 


Lys Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr 
785                 790                 795                 800 


Glu Cys Glu Lys Lys Cys Lys Thr Lys Cys Lys Asp Glu Cys Asp Ala 
                805                 810                 815     


Tyr Lys Asn Phe Ile Glu Asn Cys Lys Gly Gly Asp Gly Thr Ala Gly 
            820                 825                 830         


Ser Pro Trp Ser Lys Arg Trp Asp Gln Ile Tyr Met Arg Tyr Ser Lys 
        835                 840                 845             


Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys 
    850                 855                 860                 


Gly Thr Ser Ala Ala Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser 
865                 870                 875                 880 


Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr 
                885                 890                 895     


Leu Ser Ile Val Leu Asp Glu Asn Ile Cys Gly Asp Asp Asn Ala Pro 
            900                 905                 910         


Trp Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys 
        915                 920                 925             


Ser Lys Ser Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser 
    930                 935                 940                 


Pro Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Val Cys Glu Cys Arg 
945                 950                 955                 960 


Thr Pro Ser Asn Glu Glu Thr Cys Asp Asp Arg Lys Glu Tyr Met Asn 
                965                 970                 975     


Gln Trp Ile Ser Asp Thr Ser Lys Asn Pro Lys Gly Ser Gly Ser Gly 
            980                 985                 990         


Lys Asp Tyr Tyr Glu Leu Cys Lys  Tyr Asn Gly Val Lys  Glu Thr Lys 
        995                 1000                 1005             


Leu Pro  Lys Lys Ser Ser Ser  Thr Lys Leu Asp Glu  Asn Asp Val 
    1010                 1015                 1020             


Met Phe  Phe Asn Leu Phe Glu  Gln Trp Asn Lys Glu  Ile Gln Tyr 
    1025                 1030                 1035             


Gln Ile  Glu Gln Tyr Met Thr  Asn Thr Lys Ile Ser  Cys Asn Asn 
    1040                 1045                 1050             


Glu Met  Lys Val Leu Ser Arg  Val Ser Glu Glu Ser  Lys Asn Gln 
    1055                 1060                 1065             


Asn Ser  Ser Asp Asn His Asp  Gly Gly Asn Asn Asn  Thr Asp Gln 
    1070                 1075                 1080             


Gly Thr  Asn Cys Lys Glu Lys  Cys Glu Cys Tyr Glu  Leu Trp Ile 
    1085                 1090                 1095             


Glu Lys  Ile Lys Lys Gln Trp  Glu Thr Gln Lys Lys  Asn Tyr Asn 
    1100                 1105                 1110             


Asn Phe  Glu Thr Lys Gln Ser  Asn Asp Ala Arg Lys  Ser Ser Gln 
    1115                 1120                 1125             


Asn Lys  Lys Glu Ile Val Lys  Leu Ser His Phe Leu  Phe Phe Ser 
    1130                 1135                 1140             


Cys Trp  Glu Glu Tyr Ile Gln  Lys Tyr Phe Asn Gly  Asp Trp Ser 
    1145                 1150                 1155             


Lys Ile  Lys Asn Ile Gly Ser  Asp Thr Phe Glu Phe  Leu Ile Lys 
    1160                 1165                 1170             


Lys Cys  Gly Asn Asn Ser Gly  Asp Gly Glu Thr Ile  Phe Ser Glu 
    1175                 1180                 1185             


Lys Leu  Asn Asn Ala Gln Gln  Gln Cys Lys Glu Ile  Gln Asn Thr 
    1190                 1195                 1200             


Asp Thr  Lys Ile Asn Lys Ser  Glu Thr Ser Ser Val  Leu Asn Ala 
    1205                 1210                 1215             


Thr Asn  Tyr Ile Arg Gly Cys  Gln Ser Lys Thr Tyr  Asp Gly Lys 
    1220                 1225                 1230             


Ile Phe  Pro Gly Lys Gly Gly  Glu Lys Gln Trp Ile  Cys Lys Asp 
    1235                 1240                 1245             


Thr Ile  Ile His Gly Asp Thr  Asn Gly Ala Cys Ile  Pro Pro Arg 
    1250                 1255                 1260             


Thr Gln  Asn Leu Cys Val Gly  Glu Leu Trp Asp Lys  Arg Tyr Gly 
    1265                 1270                 1275             


Gly Arg  Ser Asn Ile Lys Asn  Asp Thr Lys Glu Ser  Leu Lys Gln 
    1280                 1285                 1290             


Lys Ile  Lys Asn Ala Ile Gln  Lys Glu Thr Glu Leu  Leu Tyr Glu 
    1295                 1300                 1305             


Tyr His  Asp Lys Gly Thr Ala  Ile Ile Ser Arg Asn  Pro Met Lys 
    1310                 1315                 1320             


Gly Lys  Lys Ala Asn Asn Asn  Lys Asn Ser Asn Gly  Leu Pro Lys 
    1325                 1330                 1335             


Gly Phe  Cys His Ala Val Gln  Arg Ser Phe Ile Asp  Tyr Lys Asn 
    1340                 1345                 1350             


Met Ile  Leu Gly Thr Ser Val  Asn Ile Tyr Glu Tyr  Ile Gly Lys 
    1355                 1360                 1365             


Leu Gln  Glu Asp Ile Lys Lys  Ile Ile Glu Gln Glu  Thr Thr Lys 
    1370                 1375                 1380             


Gln Lys  Asp Lys Ile Gly Gly  Val Gly Ser Ser Ala  Asp Lys Val 
    1385                 1390                 1395             


Asn Asp  Trp Trp Lys Gly Ile  Glu Gly Glu Met Trp  Gly Ala Val 
    1400                 1405                 1410             


Lys Ser  Gly Ile Lys Thr Ile  Lys Lys Gln Asn Asn  Lys Cys Thr 
    1415                 1420                 1425             


Tyr Thr  Gly Asn Glu Cys Gly  Val Ser Pro Pro Thr  Gly Asn Asp 
    1430                 1435                 1440             


Glu Asp  Gln Ser Val Ser Trp  Phe Lys Glu Trp Gly  Glu Gln Phe 
    1445                 1450                 1455             


Cys Ile  Glu Arg Leu Gln Tyr  Glu Gln Asn Ile Arg  Asp Ala Cys 
    1460                 1465                 1470             


Thr Asn  Asn Gly Lys Asn Gly  Lys Lys Cys Ile Asn  Ser Lys Ser 
    1475                 1480                 1485             


Gly Gln  Glu Asp Lys Ile Gln  Gly Asp Cys Lys Arg  Lys Cys Glu 
    1490                 1495                 1500             


Lys Tyr  Lys Lys Tyr Ile Ser  Glu Lys Lys Lys Glu  Trp Asp Lys 
    1505                 1510                 1515             


Gln Lys  Thr Lys Tyr Glu Asn  Lys Tyr Val Gly Lys  Ser Ala Ser 
    1520                 1525                 1530             


Asp Leu  Leu Lys Glu Asn Tyr  Pro Glu Cys Ile Ser  Ala Asn Phe 
    1535                 1540                 1545             


Asp Phe  Ile Phe Asn Asp Lys  Ala Asp His Lys Lys  Tyr Tyr Pro 
    1550                 1555                 1560             


Tyr Gly  Asp Tyr Asn Ser Ile  Cys Ser Cys Glu Gln  Val Lys Tyr 
    1565                 1570                 1575             


Tyr Lys  Tyr Asn Asn Ala Glu  Lys Lys Asn Asn Lys  Ser Leu Cys 
    1580                 1585                 1590             


His Glu  Lys Gly Asn Asp Arg  Thr Trp Ser Lys Lys  Tyr Ile Lys 
    1595                 1600                 1605             


Lys Leu  Glu Asn Gly Arg Thr  Leu Glu Gly Val Tyr  Val Pro Pro 
    1610                 1615                 1620             


Arg Arg  Gln Gln Leu Cys Leu  Tyr Glu Leu Phe Pro  Ile Ile Ile 
    1625                 1630                 1635             


Lys Lys  Glu Lys Asp Met Glu  Lys Ala Lys Glu Glu  Leu Leu Glu 
    1640                 1645                 1650             


Thr Leu  Gln Ile Val Ala Glu  Arg Glu Ala Tyr Tyr  Leu Trp Lys 
    1655                 1660                 1665             


Gln Tyr  Asn Pro Thr Gly Lys  Gly Ile Asp Asp Ala  Asn Lys Lys 
    1670                 1675                 1680             


Ala Cys  Cys Ala Ile Arg Gly  Ser Phe Tyr Asp Leu  Glu Asp Ile 
    1685                 1690                 1695             


Ile Lys  Gly Asn Asp Leu Val  His Asp Glu Tyr Thr  Lys Tyr Ile 
    1700                 1705                 1710             


Asp Ser  Lys Leu Asn Lys Ile  Phe Gly Ser Ser Asn  Thr Asn Asn 
    1715                 1720                 1725             


Ile Asp  Thr Lys Arg Ala Arg  Thr Asp Trp Trp Glu  Asn Lys Thr 
    1730                 1735                 1740             


Ile Asp  Val Pro Lys Ile Asp  Val Ala Asn Gly Thr  Asp Ser Lys 
    1745                 1750                 1755             


Thr Ile  Arg Gln Leu Val Trp  Asp Ala Met Gln Ser  Gly Val Arg 
    1760                 1765                 1770             


Tyr Ala  Val Glu Lys Asn Glu  Lys Lys Lys Gln Asn  Glu Asn Phe 
    1775                 1780                 1785             


Pro Pro  Cys Met Arg Val Gln  His Ile Gly Ile Ala  Lys Pro Gln 
    1790                 1795                 1800             


Phe Ile  Arg Trp Leu Glu Glu  Trp Thr Asn Glu Phe  Cys Glu Lys 
    1805                 1810                 1815             


Tyr Thr  Lys Tyr Phe Glu Asp  Met Lys Ser Asn Cys  Asp Pro Pro 
    1820                 1825                 1830             


Lys Gly  Ala Asp Asp Cys Gly  Asp Asn Ser Asn Ile  Glu Cys Lys 
    1835                 1840                 1845             


Lys Ala  Cys Ala Asn Tyr Thr  Asn Trp Leu Asn Pro  Lys Arg Ile 
    1850                 1855                 1860             


Glu Trp  Asn Gly Met Ser Asn  Tyr Tyr Asn Lys Ile  Tyr Arg Lys 
    1865                 1870                 1875             


Ser Asn  Lys Glu Ser Glu Asp  Gly Lys Asp Tyr Ser  Met Ile Met 
    1880                 1885                 1890             


Glu Pro  Thr Val Ile Asp Tyr  Leu Asn Lys Arg Cys  His Gly Glu 
    1895                 1900                 1905             


Ile Asn  Gly Asn Tyr Ile Cys  Cys Ser Cys Lys Asn  Ile Gly Glu 
    1910                 1915                 1920             


Asn Ser  Thr Ser Pro Ala Gln  Lys Thr Lys Gly Ser  Lys Lys Lys 
    1925                 1930                 1935             


Gly Glu  Gln Cys Glu Asp Asn  Lys Gly Pro Leu Asp  Leu Met Asn 
    1940                 1945                 1950             


Glu Val  Leu Asn Lys Met Asp  Glu Lys Tyr Ser Ala  His Lys Met 
    1955                 1960                 1965             


Lys Cys  Thr Glu Val Tyr Leu  Glu His Val Glu Glu  Gln Leu Lys 
    1970                 1975                 1980             


Glu Ile  Asp Asn Ala Ile Lys  Asp Tyr Gln Leu Tyr  Pro Leu Asp 
    1985                 1990                 1995             


Arg Cys  Phe Asp Asp Gln Thr  Lys Met Lys Val Cys  Asp Leu Ile 
    2000                 2005                 2010             


Arg Asp  Ala Ile Gly Cys Lys  Asp Lys Thr Lys Leu  Asp Glu Leu 
    2015                 2020                 2025             


Asp Glu  Trp Asn Asp Val Asp  Met Arg Asp Pro Tyr  Asn Lys Tyr 
    2030                 2035                 2040             


Lys Gly  Val Leu Ile Pro Pro  Arg Arg Arg Gln Leu  Cys Phe Ser 
    2045                 2050                 2055             


Arg Ile  Val Arg Gly Pro Ala  Asn Leu Arg Asn Leu  Asn Glu Phe 
    2060                 2065                 2070             


Lys Glu  Glu Ile Leu Lys Gly  Ala Gln Ser Glu Gly  Lys Phe Leu 
    2075                 2080                 2085             


Gly Asn  Tyr Tyr Lys Glu His  Lys Gly Asn Tyr Tyr  Asn Glu Asp 
    2090                 2095                 2100             


Lys Asp  Lys Glu Lys Ala Leu  Glu Ala Met Lys Asn  Ser Phe Tyr 
    2105                 2110                 2115             


Asp Tyr  Glu Tyr Ile Ile Lys  Gly Ser Asp Met Leu  Thr Asn Ile 
    2120                 2125                 2130             


Gln Phe  Lys Asp Ile Lys Ile  Lys Leu Asp Lys Leu  Leu Thr Lys 
    2135                 2140                 2145             


Glu Thr  Asn Asn Asn Ile Gln  Asn Ala Glu Asp Trp  Trp Lys Val 
    2150                 2155                 2160             


Asn Asn  Lys Ser Ile Trp Asn  Ala Met Leu Cys Gly  Tyr Lys Lys 
    2165                 2170                 2175             


Ser Gly  Asn Lys Ile Ile Asp  Pro Ser Trp Cys Thr  Ile Pro Thr 
    2180                 2185                 2190             


Thr Glu  Lys Thr Pro Gln Phe  Leu Arg Trp Ile Lys  Glu Trp Gly 
    2195                 2200                 2205             


Thr Asn  Val Cys Ile Glu Lys  Glu Lys Tyr Lys Gln  Asn Val Lys 
    2210                 2215                 2220             


Leu Glu  Cys Ser Asp Val Pro  Asn Asn Asn Leu Gly  Ser Gln Glu 
    2225                 2230                 2235             


Ser Glu  Ser Asn Asn Cys Thr  Ser Glu Ile Arg Lys  Tyr Gln Glu 
    2240                 2245                 2250             


Trp Ser  Arg Asn Arg Ser Ile  Gln Trp Glu Ala Ile  Ser Glu Arg 
    2255                 2260                 2265             


Tyr Lys  Lys Tyr Lys Gly Met  Asp Ile Leu Lys Asp  Val Lys Glu 
    2270                 2275                 2280             


Pro Asp  Ala Asn Thr Tyr Leu  Lys Glu His Cys Ser  Lys Cys Pro 
    2285                 2290                 2295             


Cys Gly  Phe Asn Asp Met Gln  Glu Ile Ala Asn Asp  Thr Glu Asn 
    2300                 2305                 2310             


Lys Gln  Asp Ile Phe Lys Gln  Ile Ile Glu Lys Val  Lys Ile Pro 
    2315                 2320                 2325             


Ala Glu  Leu Glu Asp Val Ile  Tyr Arg Leu Lys His  His Glu Tyr 
    2330                 2335                 2340             


Asn Ser  Asn Asp Tyr Ile Cys  Asn Lys Tyr Lys Asn  Ile Asn Val 
    2345                 2350                 2355             


Asn Met  Arg His Lys Asn Asp  Asp Thr Trp Thr Asp  Leu Leu Val 
    2360                 2365                 2370             


Lys Asn  Ser Ser Asp Ile Asn  Lys Gly Val Leu Ile  Pro Pro Arg 
    2375                 2380                 2385             


Arg Lys  Asn Leu Phe Leu Asn  Ile Asp Glu Ser Asp  Ile Cys Lys 
    2390                 2395                 2400             


Tyr Lys  Lys Asn Pro Lys Leu  Phe Lys Asp Phe Ile  Tyr Ser Ser 
    2405                 2410                 2415             


Ala Phe  Thr Glu Val Glu Arg  Leu Lys Ile Val Tyr  Gly Glu Ala 
    2420                 2425                 2430             


Lys Thr  Lys Val Ala His Ala  Met Lys Tyr Ser Phe  Ala Asp Ile 
    2435                 2440                 2445             


Gly Asn  Ile Ile Lys Gly Asp  Asp Met Met Glu Asn  Pro Thr Ser 
    2450                 2455                 2460             


Lys Tyr  Met Asp Lys Leu Phe  Thr Ser Asn Lys Tyr  Ser Gly Ile 
    2465                 2470                 2475             


Asn Arg  Glu Thr Trp Trp Asn  Glu Asn Lys Tyr His  Val Trp Glu 
    2480                 2485                 2490             


Ser Met  Leu Cys Gly Tyr Gln  Lys Gly Lys Asn Asn  Thr His Ser 
    2495                 2500                 2505             


Glu Lys  Leu Asp Glu Ala Trp  Cys Asp Leu Pro Met  Glu Gly Asp 
    2510                 2515                 2520             


Ile Pro  Gln Phe Leu Arg Trp  Phe Gln Glu Trp Thr  Glu Thr Phe 
    2525                 2530                 2535             


Cys Thr  Arg Gln Lys Glu Leu  Lys Glu Asn Val Lys  Lys Glu Cys 
    2540                 2545                 2550             


Asn Lys  Val Thr Cys Asp Lys  Asp Thr Gly Lys Thr  Asp Ile Lys 
    2555                 2560                 2565             


Cys Thr  Glu Ala Cys Lys Asn  Tyr Ser Asn Phe Ile  Ser Ile Lys 
    2570                 2575                 2580             


Gln Asn  Glu Tyr Glu Ser Leu  Lys Lys Gln Tyr Asn  Asp Asn His 
    2585                 2590                 2595             


Lys Ser  Thr Gln Ala Asp Gly  Lys Glu Ala His Leu  Tyr Phe Lys 
    2600                 2605                 2610             


Glu Lys  Cys Lys Asp Asn Lys  Cys Asn Cys Leu His  Glu Lys Phe 
    2615                 2620                 2625             


Asn Ser  Glu Asp Asn Trp Lys  Lys Pro Tyr Glu Thr  Leu Asp Asp 
    2630                 2635                 2640             


Thr Glu  Leu Lys Asn Lys Cys  Met Cys Lys Pro Pro  Pro Pro Ala 
    2645                 2650                 2655             


Ser Asn  Asn Thr Ser Asp Ile  Leu Gln Lys Thr Ile  Pro Phe Gly 
    2660                 2665                 2670             


Ile Ala  Leu Ala Leu Gly Ser  Ile Ala Phe Leu Phe  Met Lys Lys 
    2675                 2680                 2685             


Lys Pro  Lys Thr Pro Val Asp  Leu Leu Arg Val Leu  Asp Ile His 
    2690                 2695                 2700             


Lys Gly  Asp Tyr Gly Ile Pro  Thr Leu Lys Ser Ser  Asn Arg Tyr 
    2705                 2710                 2715             


Ile Pro  Tyr Val Ser Asp Thr  Tyr Lys Gly Lys Thr  Tyr Ile Tyr 
    2720                 2725                 2730             


Met Glu  Gly Glu Glu Thr Asp  Asp Tyr Ser Tyr Ile  Arg Asp Ile 
    2735                 2740                 2745             


Ser Ser  Ser Asp Ile Thr Ser  Ser Ser Glu Ser Glu  Tyr Glu Glu 
    2750                 2755                 2760             


Leu Asp  Ile Asn Asp Ile Tyr  Val Pro Ser Leu Pro  Lys Tyr Lys 
    2765                 2770                 2775             


Thr Leu  Ile Glu Val Val Leu  Glu Pro Ser Lys Arg  Asp Thr Phe 
    2780                 2785                 2790             


Asn Thr  Ser Ser Gly Asp Thr  Phe Thr Asn Lys Leu  Thr Asp Asp 
    2795                 2800                 2805             


Glu Trp  Asn Gln Leu Lys Gln  Asp Phe Ile Glu Gln  Tyr Leu Gln 
    2810                 2815                 2820             


Asn Ile  Gln Lys Asp Phe Ile  Leu His Asp Ser Met  Asp Glu Lys 
    2825                 2830                 2835             


Pro Phe  Ile Thr Gln Ile Gln  Asp Arg Phe Leu Asp  Ser Ser His 
    2840                 2845                 2850             


Glu Glu  Val Thr Tyr Asn Ile  Asp Trp Asn Val Pro  Glu Asn Ile 
    2855                 2860                 2865             


Asn Arg  Ile Thr Asn Asn Met  Asp Asp Pro Lys Tyr  Ser Ser Asn 
    2870                 2875                 2880             


Asn Leu  Tyr Thr Gly Thr Asp  Leu Ile Asn Asp Ser  Leu Asn Gly 
    2885                 2890                 2895             


Asn Gln  Tyr Ile Asp Ile Tyr  Asp Glu Met Leu Lys  Arg Lys Glu 
    2900                 2905                 2910             


Asn Glu  Leu Phe Gly Thr Tyr  His Thr Lys Tyr Thr  Thr Phe Asn 
    2915                 2920                 2925             


Ser Val  Ser Lys Gln Thr Pro  Ser Asp Pro Ile Ile  Asn Gln Leu 
    2930                 2935                 2940             


Asp Leu  Tyr His Asn Trp Met  Asp Lys His Arg Asp  Ile Cys Glu 
    2945                 2950                 2955             


Gln Cys  Lys Thr Lys Lys Asp  Met Leu Tyr Lys Leu  Asn Glu Val 
    2960                 2965                 2970             


Trp Asn  Met Glu Arg Lys Glu  Tyr Leu Leu Asp Ile  Gln Pro Ser 
    2975                 2980                 2985             


Thr Leu  Asp Asp Ile His Lys  Ile Asn Asp Glu Thr  Tyr Asn Ile 
    2990                 2995                 3000             


Ile Ser  Thr Asn Asn Ile Tyr  Asp His Pro Ser Gln  Glu Thr Pro 
    3005                 3010                 3015             


Leu Gln  Leu Leu Ala Ser Thr  Asn Ile Ile Pro Ser  Tyr Ile Thr 
    3020                 3025                 3030             


Thr Glu  Gln Asn Asn Gly Leu  Arg Thr Asn Ile Ser  Met Asp Thr 
    3035                 3040                 3045             


Tyr Ile  Asp Glu Thr Asn Asn  Asn Asn Val Val Ala  Thr Ser Ile 
    3050                 3055                 3060             


Ile Gly  Asp Asp Gln Met Glu  Asn Ser Tyr Asn Cys  
    3065                 3070                 3075 


<210>  66
<211>  3096
<212>  PRT
<213>  Plasmodium falciparum

<400>  66

Met Asp Ser Lys Thr Thr Ile Ala Glu Lys Ile Glu Ala Tyr Leu Gly 
1               5                   10                  15      


Ala Lys Ser Asn Asp Ser Lys Ile Asp Gln Ser Leu Lys Ala Asp Pro 
            20                  25                  30          


Ser Glu Val Gln Tyr Tyr Gly Ser Gly Gly Asp Gly Tyr Tyr Leu Lys 
        35                  40                  45              


Asn Asn Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn 
    50                  55                  60                  


Asp Pro Cys Asp Ser Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp 
65                  70                  75                  80  


Lys Cys Gln Gln Asn Ser Ser Asp Gly Ser Glu Lys Pro Glu Asn Val 
                85                  90                  95      


Phe Val Pro Pro Arg Arg Gln Arg Met Cys Ile Lys Asn Leu Glu Asn 
            100                 105                 110         


Leu Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val 
        115                 120                 125             


Leu Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Ile Leu Tyr His Pro 
    130                 135                 140                 


Asp Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala 
145                 150                 155                 160 


Asp Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn 
                165                 170                 175     


Ser Asn Leu Glu Gln Asn Leu Arg Arg Met Phe Ala Lys Ile Arg Glu 
            180                 185                 190         


Asn Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Thr 
        195                 200                 205             


Lys Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu 
    210                 215                 220                 


Val Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly 
225                 230                 235                 240 


Trp Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys 
                245                 250                 255     


Arg Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Gln Leu Asp Tyr 
            260                 265                 270         


Val Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr 
        275                 280                 285             


Arg Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu 
    290                 295                 300                 


Cys Thr Arg Glu Tyr Asp Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser 
305                 310                 315                 320 


Thr Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp 
                325                 330                 335     


Lys Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Asn Asp Leu Tyr Gln 
            340                 345                 350         


Gln Asn Lys Asn Lys Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asn 
        355                 360                 365             


Tyr Val Lys Glu Phe Phe Lys Asn Phe Lys Gly Asp Asn Tyr Lys Ser 
    370                 375                 380                 


Leu Glu Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Val Thr 
385                 390                 395                 400 


Lys Leu Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Thr Ser Ser Glu 
                405                 410                 415     


Lys Ile Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Glu 
            420                 425                 430         


Ile Ala Ser Val Gly Gln Ala Ser Ile Ser Asp Pro Ser Ser Asn Lys 
        435                 440                 445             


Thr Cys Asn Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys 
    450                 455                 460                 


Lys Asp Val Lys Leu Gly Val Arg Glu Lys Asp Lys Asp Leu Lys Ile 
465                 470                 475                 480 


Cys Val Ile Glu Asp Asp Ser Leu Arg Gly Val Asp Asn Cys Cys Cys 
                485                 490                 495     


Gln Asp Leu Leu Gly Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Arg 
            500                 505                 510         


Gly Ser Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Asp Glu Cys 
        515                 520                 525             


Gln Lys Lys Leu Glu Asn Val Phe Ala Ser Leu Thr Asn Gly Tyr Lys 
    530                 535                 540                 


Cys Asp Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Asn Lys Trp 
545                 550                 555                 560 


Ile Trp Arg Lys Phe Pro Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr 
                565                 570                 575     


Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Leu Leu Tyr Leu Val 
            580                 585                 590         


Cys Leu His Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg 
        595                 600                 605             


Thr Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu 
    610                 615                 620                 


Gly Lys Asn Leu Lys Thr Thr Tyr Pro Gln Lys Lys Asn Asp Asp Asn 
625                 630                 635                 640 


Gly Lys Lys Leu Cys Lys Asp Leu Lys Tyr Ser Phe Ala Asp Tyr Gly 
                645                 650                 655     


Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Asp Phe Thr Lys Asp 
            660                 665                 670         


Leu Glu Leu Asn Leu Gln Gln Ile Phe Gly Lys Leu Phe Arg Lys Tyr 
        675                 680                 685             


Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp 
705                 710                 715                 720 


Thr Ala Met Lys His Gly Ala Gly Met Asn Ser Thr Met Cys Asn Ala 
                725                 730                 735     


Asp Gly Ser Val Thr Gly Ser Ser Asp Ser Gly Ser Thr Thr Cys Ser 
            740                 745                 750         


Gly Asp Asn Gly Ser Ile Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu 
        755                 760                 765             


Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe Cys 
    770                 775                 780                 


Glu Gln Arg Gln Ala Lys Val Asn Ala Val Ile Thr Asn Cys Lys Ser 
785                 790                 795                 800 


Cys Lys Glu Ser Gly Gly Thr Cys Asn Ser Asp Cys Lys Thr Glu Cys 
                805                 810                 815     


Lys Asn Lys Cys Lys Val Ala Cys Asp Ala Tyr Lys Thr Phe Ile Glu 
            820                 825                 830         


Asp Cys Lys Gly Gly Gly Thr Gly Thr Ala Gly Ser Ser Trp Val Lys 
        835                 840                 845             


Arg Trp Tyr Gln Ile Tyr Met Arg Tyr Ser Lys Tyr Ile Glu Asp Ala 
    850                 855                 860                 


Lys Arg Asn Arg Lys Ala Gly Thr Lys Ser Cys Gly Thr Ser Ser Gly 
865                 870                 875                 880 


Ala Asn Ser Gly Val Thr Thr Ala Glu Asn Lys Cys Val Gln Ser Asp 
                885                 890                 895     


Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro 
            900                 905                 910         


Ser Ser Tyr Leu Ser Asn Val Leu Asp Glu Asn Asn Cys Gly Glu Asp 
        915                 920                 925             


Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Tyr Thr Thr Tyr 
    930                 935                 940                 


Thr Thr Thr Lys Asn Cys Asp Lys Asp Lys Lys Lys Ser Lys Ser Gln 
945                 950                 955                 960 


Ser Cys Asp Thr Leu Val Val Val Asn Val Pro Ser Pro Leu Gly Asn 
                965                 970                 975     


Thr Pro His Gly Tyr Lys Tyr Ala Cys Glu Cys Lys Ile Pro Thr Thr 
            980                 985                 990         


Glu Glu Thr Cys Asp Asp Arg Lys  Glu Tyr Met Asn Gln  Trp Ile Ile 
        995                 1000                 1005             


Asp Thr  Ser Lys Lys Gln Lys  Gly Ser Gly Ser Thr  Asn Asn Asp 
    1010                 1015                 1020             


Tyr Glu  Leu Tyr Thr Tyr Asn  Gly Val Lys Glu Thr  Lys Pro Leu 
    1025                 1030                 1035             


Gly Thr  Leu Asn Ser Ser Lys  Leu Asp Asp Lys Asp  Val Met Phe 
    1040                 1045                 1050             


Phe Asn  Leu Phe Glu Gln Trp  Asn Lys Glu Ile Gln  Tyr Gln Ile 
    1055                 1060                 1065             


Glu Gln  Tyr Met Thr Asn Thr  Lys Ile Ser Cys Asn  Asn Glu Met 
    1070                 1075                 1080             


Lys Val  Leu Ser Ser Ser Ser  Glu Glu Ser Gln Asn  Arg Asn Gly 
    1085                 1090                 1095             


Ser Asp  His His Asp Gly Arg  Asn Asn Asn Ile Asn  Gln Gly Thr 
    1100                 1105                 1110             


Asn Cys  Lys Glu Lys Cys Lys  Cys Tyr Glu Leu Trp  Ile Lys Lys 
    1115                 1120                 1125             


Ile Lys  Glu Gln Trp Asp Lys  Gln Lys Asn Asn Tyr  Asn Lys Phe 
    1130                 1135                 1140             


Gln Arg  Lys Gln Ile Tyr Asp  Ala Asn Lys Gly Pro  Gln Asn Lys 
    1145                 1150                 1155             


Lys Val  Val Ser Leu Ser His  Phe Leu Phe Phe Ser  Cys Trp Glu 
    1160                 1165                 1170             


Glu Tyr  Ile Gln Lys Tyr Phe  Asn Gly Asp Trp Ser  Lys Ile Lys 
    1175                 1180                 1185             


Asn Ile  Gly Ser Asp Thr Phe  Glu Tyr Leu Ile Lys  Lys Cys Gly 
    1190                 1195                 1200             


Asn Asn  Ser Gly Asp Gly Glu  Thr Ile Phe Ser Glu  Lys Leu Lys 
    1205                 1210                 1215             


Asn Ala  Glu Lys Lys Cys Lys  Glu Asn Lys Ser Thr  Asn Asn Lys 
    1220                 1225                 1230             


Met Lys  Ser Ser Gly Lys Ser  Ser Asp Cys Ser Glu  Thr Asn Tyr 
    1235                 1240                 1245             


Ile Arg  Gly Cys Gln Ser Lys  Thr Tyr Asp Gly Lys  Ile Phe Pro 
    1250                 1255                 1260             


Gly Lys  Gly Gly Glu Lys Gln  Trp Ile Cys Lys Asp  Thr Ile Thr 
    1265                 1270                 1275             


His Gly  Asp Thr Asn Gly Ala  Cys Ile Pro Pro Arg  Thr Gln Asn 
    1280                 1285                 1290             


Leu Cys  Val Gly Glu Leu Trp  Tyr Lys Ser Tyr Gly  Gly Arg Ser 
    1295                 1300                 1305             


Asn Ile  Lys Asn Asp Thr Lys  Glu Ser Leu Lys Asn  Lys Leu Lys 
    1310                 1315                 1320             


Asn Ala  Ile Gln Lys Glu Thr  Glu Leu Leu Tyr Glu  Tyr His Asp 
    1325                 1330                 1335             


Lys Gly  Thr Ala Ile Ile Ser  Gln Asn Asp Lys Lys  Glu Lys Ala 
    1340                 1345                 1350             


Asn Asn  Asn Asp Ser Asn Gly  Leu Pro Lys Gly Phe  Cys His Ala 
    1355                 1360                 1365             


Val Gln  Arg Ser Phe Ile Asp  Tyr Lys Asn Met Ile  Leu Gly Thr 
    1370                 1375                 1380             


Ser Val  Asn Ile Tyr Glu Tyr  Ile Gly Lys Leu Gln  Glu Asp Ile 
    1385                 1390                 1395             


Lys Lys  Ile Ile Glu Lys Gly  Thr Thr Lys Gln Lys  Asp Lys Ile 
    1400                 1405                 1410             


Gly Gly  Ser Gly Ala Asp Lys  Val Asn Asp Trp Trp  Lys Gly Ile 
    1415                 1420                 1425             


Glu Gly  Glu Met Trp Asp Ala  Val Lys Cys Gly Ile  Thr Lys Ile 
    1430                 1435                 1440             


Asn Lys  Lys Gln Lys Lys Asn  Gly Thr Phe Asn Gly  Asp Glu Cys 
    1445                 1450                 1455             


Gly Val  Ser Pro Pro Thr Gly  Asn Asp Glu Asp Gln  Phe Val Ser 
    1460                 1465                 1470             


Trp Phe  Lys Glu Trp Gly Glu  Gln Phe Cys Ile Glu  Arg Leu Arg 
    1475                 1480                 1485             


Tyr Glu  Gln Asn Ile Arg Glu  Ala Cys Thr Ile Asn  Gly Lys Asn 
    1490                 1495                 1500             


Gly Lys  Lys Cys Ile Asn Ser  Lys Ser Gly Gln Gly  Asp Lys Val 
    1505                 1510                 1515             


Glu Gly  Ala Cys Lys Arg Lys  Cys Glu Lys Tyr Lys  Lys Tyr Ile 
    1520                 1525                 1530             


Ser Glu  Lys Lys Gln Glu Trp  Asp Lys Gln Lys Thr  Lys Tyr Glu 
    1535                 1540                 1545             


Asn Lys  Tyr Val Gly Lys Ser  Ala Ser Asp Leu Leu  Lys Glu Asn 
    1550                 1555                 1560             


Tyr Pro  Glu Cys Ile Ser Ala  Asn Phe Asp Phe Ile  Phe Asn Asp 
    1565                 1570                 1575             


Asn Ile  Glu Tyr Lys Thr Tyr  Tyr Pro Tyr Gly Asp  Tyr Ser Ser 
    1580                 1585                 1590             


Ile Cys  Ser Cys Glu Gln Val  Lys Tyr Tyr Glu Tyr  Asn Asn Ala 
    1595                 1600                 1605             


Glu Lys  Lys Asn Asn Lys Ser  Leu Cys His Glu Lys  Gly Asn Asp 
    1610                 1615                 1620             


Arg Thr  Trp Ser Lys Lys Tyr  Ile Lys Lys Leu Glu  Asn Gly Arg 
    1625                 1630                 1635             


Thr Leu  Glu Gly Val Tyr Val  Pro Pro Arg Arg Gln  Gln Leu Cys 
    1640                 1645                 1650             


Leu Tyr  Glu Leu Phe Pro Ile  Ile Ile Lys Lys Glu  Lys Asp Met 
    1655                 1660                 1665             


Glu Lys  Ala Lys Lys Glu Leu  Leu Glu Thr Leu Lys  Ile Val Ala 
    1670                 1675                 1680             


Glu Arg  Glu Ala Tyr Tyr Leu  Trp Lys Gln Tyr Asn  Pro Thr Gly 
    1685                 1690                 1695             


Lys Gly  Ile Asp Asp Ala Asn  Lys Lys Ala Cys Cys  Ala Ile Arg 
    1700                 1705                 1710             


Gly Ser  Phe Tyr Asp Leu Glu  Asp Ile Ile Lys Gly  Asn Asp Leu 
    1715                 1720                 1725             


Val His  Asp Glu Tyr Thr Lys  Tyr Ile Asp Ser Lys  Leu Asn Glu 
    1730                 1735                 1740             


Ile Phe  Gly Ser Ser Asn Lys  Asn Asp Ile Asp Thr  Lys Arg Ala 
    1745                 1750                 1755             


Arg Thr  Asp Trp Trp Glu Asn  Glu Thr Ile Asp Val  Pro Asn Ile 
    1760                 1765                 1770             


Thr Gly  Ala Asn Lys Ser Asp  Ser Lys Thr Ile Arg  Gln Leu Val 
    1775                 1780                 1785             


Trp Asp  Ala Met Gln Ser Gly  Val Arg Lys Ala Ile  Tyr Glu Glu 
    1790                 1795                 1800             


Lys Glu  Lys Lys Lys Gln Asn  Glu Asn Phe Pro Pro  Cys Met Arg 
    1805                 1810                 1815             


Val Glu  His Ile Gly Ile Ala  Lys Pro Gln Phe Ile  Arg Trp Leu 
    1820                 1825                 1830             


Glu Glu  Trp Thr Asn Glu Phe  Cys Glu Glu Tyr Thr  Lys Tyr Phe 
    1835                 1840                 1845             


Glu Asp  Met Lys Ser Lys Cys  Asp Pro Pro Lys Arg  Ala Asp Asp 
    1850                 1855                 1860             


Cys Gly  Asp Asn Thr Asn Ile  Glu Cys Lys Lys Ala  Cys Ala Asn 
    1865                 1870                 1875             


Tyr Thr  Asn Trp Leu Asn Pro  Lys Arg Ile Glu Trp  Asn Gly Met 
    1880                 1885                 1890             


Ser Asn  Tyr Tyr Asn Lys Ile  Tyr Arg Lys Ser Asn  Lys Glu Ser 
    1895                 1900                 1905             


Glu Asp  Gly Lys Asp Tyr Ser  Met Ile Met Glu Pro  Thr Val Ile 
    1910                 1915                 1920             


Asp Tyr  Leu Asn Lys Arg Cys  His Gly Glu Ile Asn  Gly Asn Tyr 
    1925                 1930                 1935             


Ile Cys  Cys Ser Cys Lys Asn  Ile Gly Glu Asn Tyr  Asn Pro Ser 
    1940                 1945                 1950             


Pro Ala  Gln Lys Thr Lys Gly  Ser Lys Lys Lys Asp  Glu Gln Cys 
    1955                 1960                 1965             


Glu Asp  Asn Lys Gly Pro Leu  Asp Leu Met Asn Glu  Val Leu Asn 
    1970                 1975                 1980             


Lys Met  Asp Glu Lys Tyr Ser  Ala His Lys Met Lys  Cys Thr Glu 
    1985                 1990                 1995             


Val Tyr  Leu Glu His Val Glu  Glu Gln Leu Lys Glu  Ile Asp Asn 
    2000                 2005                 2010             


Ala Ile  Lys Asp Tyr Lys Leu  Tyr Pro Leu Asp Arg  Cys Phe Asp 
    2015                 2020                 2025             


Asp Gln  Thr Lys Met Lys Ile  Cys Asp Leu Ile Gly  Asp Ala Ile 
    2030                 2035                 2040             


Gly Cys  Lys Asp Lys Thr Lys  Leu Asp Glu Leu Asp  Glu Trp Asn 
    2045                 2050                 2055             


Asp Met  Asp Leu Arg Asp Pro  Tyr Asn Lys His Lys  Gly Val Leu 
    2060                 2065                 2070             


Ile Pro  Pro Arg Arg Arg Gln  Leu Cys Phe Ser Arg  Ile Val Arg 
    2075                 2080                 2085             


Gly Pro  Ala Asn Leu Arg Asn  Leu Asn Glu Phe Lys  Glu Glu Ile 
    2090                 2095                 2100             


Leu Lys  Gly Ala Gln Ser Glu  Gly Lys Phe Leu Gly  Asn Tyr Tyr 
    2105                 2110                 2115             


Asn Glu  Asp Lys Asp Lys Glu  Lys Lys Glu His Lys  Asp Lys Glu 
    2120                 2125                 2130             


Lys Ala  Leu Glu Ala Met Lys  Asn Ser Phe Tyr Asp  Tyr Glu Asp 
    2135                 2140                 2145             


Ile Ile  Lys Gly Ser Asp Met  Leu Ala Asn Ile Gln  Phe Lys Asp 
    2150                 2155                 2160             


Ile Lys  Arg Lys Leu Asp Lys  Leu Leu Thr Lys Glu  Thr Asn Asn 
    2165                 2170                 2175             


Asn Ile  Gln Asn Ala Glu Asp  Trp Trp Lys Val Asn  Asn Lys Ser 
    2180                 2185                 2190             


Ile Trp  Asn Ala Met Leu Cys  Gly Tyr Lys Lys Ser  Gly Asn Lys 
    2195                 2200                 2205             


Ile Ile  Asp Pro Ser Trp Cys  Thr Ile Pro Thr Thr  Glu Lys Thr 
    2210                 2215                 2220             


Pro Gln  Phe Leu Arg Trp Val  Lys Glu Trp Gly Thr  Asn Val Cys 
    2225                 2230                 2235             


Ile Gln  Lys Gln Glu His Lys  Glu Tyr Val Lys Ser  Lys Cys Ser 
    2240                 2245                 2250             


Asn Val  Thr Asn Leu Gly Ala  Gln Glu Ser Glu Ser  Ser Asn Cys 
    2255                 2260                 2265             


Ile Ser  Glu Ile Arg Lys Tyr  Gln Glu Trp Ser Arg  Asn Arg Ser 
    2270                 2275                 2280             


Ile Gln  Trp Glu Ala Ile Ser  Glu Gly Tyr Lys Lys  Tyr Lys Gly 
    2285                 2290                 2295             


Met Asp  Ile Leu Lys Asp Val  Lys Glu Pro Asn Ala  Asn Glu Tyr 
    2300                 2305                 2310             


Leu Lys  Glu Tyr Cys Ser Lys  Cys Pro Cys Gly Phe  Asn Asp Met 
    2315                 2320                 2325             


Glu Glu  Ile Thr Lys Tyr Thr  Asn Ile Gly Asn Glu  Ala Phe Asn 
    2330                 2335                 2340             


Thr Ile  Ile Glu Lys Val Lys  Ile Pro Ala Glu Leu  Glu Asp Val 
    2345                 2350                 2355             


Ile Tyr  Arg Leu Lys His His  Glu Tyr Asn Ser Asn  Asp Tyr Ile 
    2360                 2365                 2370             


Cys Asn  Lys Tyr Lys Asn Ile  Asn Val Asn Met Arg  His Lys Asn 
    2375                 2380                 2385             


Asp Asp  Thr Phe Val Thr Asp  Asn Ser Val Lys Lys  Ser Trp Glu 
    2390                 2395                 2400             


Ile Ser  Asn Gly Val Leu Ile  Pro Pro Arg Arg Lys  Asn Leu Phe 
    2405                 2410                 2415             


Leu Lys  Ile Asp Gln Ser Asp  Ile Cys Glu Tyr Lys  Lys Asp Pro 
    2420                 2425                 2430             


Lys Leu  Phe Lys Asp Phe Ile  Tyr Ser Ser Ala Phe  Thr Glu Val 
    2435                 2440                 2445             


Glu Arg  Leu Lys Lys Val Tyr  Gly Glu Ala Arg Ala  Lys Val Val 
    2450                 2455                 2460             


His Ala  Met Lys Tyr Ser Phe  Ala Asp Ile Gly Asn  Ile Ile Lys 
    2465                 2470                 2475             


Gly Asp  Asp Met Met Glu Asn  Pro Thr Ser Lys Tyr  Ile Glu Gln 
    2480                 2485                 2490             


Ile Phe  Lys Gly Thr Glu Tyr  Ser Gly Ile Asp Arg  Thr Lys Trp 
    2495                 2500                 2505             


Trp Asn  Lys Asn Lys Tyr His  Val Trp Glu Ser Met  Leu Cys Gly 
    2510                 2515                 2520             


Tyr Lys  Glu Gly Gly Gly Asp  Thr Lys Thr Asn Glu  Asn Cys Arg 
    2525                 2530                 2535             


Phe Pro  Asp Thr Asp Gly Val  Pro Gln Phe Leu Arg  Trp Phe Gln 
    2540                 2545                 2550             


Glu Trp  Thr Glu Thr Phe Cys  Val Thr Arg Gln Glu  Leu Tyr Asp 
    2555                 2560                 2565             


Glu Val  Arg Thr Lys Cys Ala  Ala Ala Glu Cys Asp  Thr Thr Asn 
    2570                 2575                 2580             


Gly Thr  Ile Gly Asn Asn Cys  Thr Ile Ala Cys Gln  Glu Tyr Ser 
    2585                 2590                 2595             


Asn Tyr  Ile Leu Asn Lys Lys  Asp Glu Tyr Gln Ser  Leu Lys Tyr 
    2600                 2605                 2610             


Gln Tyr  Asp Met Asn Tyr Lys  Glu Thr Lys Gly Lys  Asn Lys Glu 
    2615                 2620                 2625             


Ala His  Glu Tyr Ile Lys Asn  Lys Cys Ser Asn Ser  Lys Cys Gln 
    2630                 2635                 2640             


Cys Leu  Ser Lys His Thr Asn  Asn Glu Asn Asn Trp  Lys Glu Pro 
    2645                 2650                 2655             


Tyr Glu  Thr Leu Asp Asn Met  Asn Leu Lys Ala Ile  Cys Asp Cys 
    2660                 2665                 2670             


Pro Lys  Pro Leu Pro Leu Phe  Ser Asp Asn Thr Ser  Asp Ile Leu 
    2675                 2680                 2685             


Gln Lys  Thr Ile Pro Phe Gly  Val Ala Leu Ala Leu  Gly Ser Ile 
    2690                 2695                 2700             


Ala Phe  Leu Phe Met Lys Lys  Lys Pro Lys Thr Pro  Val Asp Leu 
    2705                 2710                 2715             


Leu Arg  Val Leu Asp Ile His  Lys Gly Asp Tyr Gly  Ile Pro Thr 
    2720                 2725                 2730             


Thr Lys  Ser Ser Asn Arg Tyr  Ile Pro Tyr Val Ser  Asp Thr Tyr 
    2735                 2740                 2745             


Lys Gly  Lys Thr Tyr Ile Tyr  Met Glu Gly Glu Glu  Thr Asp Asp 
    2750                 2755                 2760             


Tyr Ser  Tyr Ile Arg Asp Ile  Ser Ser Ser Asp Ile  Thr Ser Ser 
    2765                 2770                 2775             


Glu Ser  Glu Tyr Glu Glu Leu  Asp Ile Asn Asp Ile  Tyr Val Pro 
    2780                 2785                 2790             


Ser Leu  Pro Lys Tyr Lys Thr  Leu Ile Glu Val Val  Leu Glu Pro 
    2795                 2800                 2805             


Ser Lys  Arg Asp Thr Phe Asn  Thr Ser Ser Gly Asp  Thr Phe Thr 
    2810                 2815                 2820             


Asn Lys  Leu Thr Asp Asp Glu  Trp Asn Gln Leu Lys  Gln Asp Phe 
    2825                 2830                 2835             


Ile Glu  Gln Tyr Leu Gln Asn  Ile Gln Lys Asp Phe  Ile Leu His 
    2840                 2845                 2850             


Asp Ser  Val Asn Glu Lys Pro  Phe Ile Thr Gln Ile  Gln Asp Arg 
    2855                 2860                 2865             


Phe Leu  Asp Ser Ser His Glu  Glu Val Ile Tyr Asn  Ile Asp Trp 
    2870                 2875                 2880             


Asn Val  Pro Glu Asn Ile Asn  Arg Ile Thr Asn Asn  Met Asp Asp 
    2885                 2890                 2895             


Pro Lys  Tyr Ser Ser Asn Asn  Leu Tyr Thr Gly Thr  Asp Leu Ile 
    2900                 2905                 2910             


Asn Asp  Ser Leu Asn Gly Asn  Gln Tyr Ile Asp Ile  Tyr Asp Glu 
    2915                 2920                 2925             


Met Leu  Lys Arg Lys Glu Asn  Glu Leu Phe Gly Thr  Tyr His Thr 
    2930                 2935                 2940             


Lys Tyr  Thr Thr Phe Asn Ser  Val Ser Lys Gln Thr  Pro Ser Asp 
    2945                 2950                 2955             


Pro Ile  Ile Asn Gln Leu Asp  Leu Tyr His Asn Trp  Met Asp Lys 
    2960                 2965                 2970             


His Arg  Asp Ile Cys Glu Gln  Trp Lys Thr Lys Glu  Asp Met Leu 
    2975                 2980                 2985             


Tyr Lys  Leu Asn Glu Val Trp  Asn Met Glu Arg Lys  Glu Tyr Leu 
    2990                 2995                 3000             


Leu Asp  Ile Gln Pro Ser Thr  Leu Asp Asp Ile His  Lys Ile Asn 
    3005                 3010                 3015             


Asp Glu  Thr Tyr Asn Ile Ile  Ser Thr Asn Asn Ile  Tyr Asp His 
    3020                 3025                 3030             


Pro Ser  Gln Glu Thr Pro Leu  Gln Leu Leu Gly Ser  Thr Asn Ile 
    3035                 3040                 3045             


Ile Pro  Ser Tyr Ile Thr Thr  Glu Gln Asn Asn Gly  Leu Arg Thr 
    3050                 3055                 3060             


Asn Ile  Ser Met Asp Thr Tyr  Ile Asp Glu Thr Asn  Asn Asn Asn 
    3065                 3070                 3075             


Val Val  Ala Thr Ser Ile Ile  Gly Asp Asp Gln Met  Glu Asn Ser 
    3080                 3085                 3090             


Tyr Asn  Cys 
    3095     


<210>  67
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  67

Asp Leu Asn Lys Ile Asn Ile Lys Asp Lys Ser Pro Thr Thr Phe Asp 
1               5                   10                  15      


Val Asp Met Ile Tyr Leu Arg Arg Gln Tyr Met Lys Asn Glu Leu Lys 
            20                  25                  30          


Ser Phe Val Glu Ser Thr Cys Leu Phe Lys Gly Met Arg Asn Gln Glu 
        35                  40                  45              


Trp Thr Cys Gln Ile Leu Lys Asn Leu Asp Val Cys Lys Leu Asn Asn 
    50                  55                  60                  


Phe Asn Lys Val Ile Asp Ile Asp Lys His Ile Thr Phe Lys Val Leu 
65                  70                  75                  80  


Leu Glu Arg Trp Leu Lys Asp Phe Leu Glu Gly Tyr Lys Lys Ser Lys 
                85                  90                  95      


Arg Lys Ile Asn Pro Cys Thr Lys Asp Lys Asn Ser Cys Ile Lys Leu 
            100                 105                 110         


Cys Ile Asn Lys Cys Thr Cys Val Glu Glu Trp Leu Asn Lys Lys Glu 
        115                 120                 125             


Lys Glu Trp Gly Gln Ile Lys Lys His Phe Asn Lys Gln Phe His Gly 
    130                 135                 140                 


Glu Gly Tyr Asp Ile Ala Phe Lys Val Lys Ser Tyr Phe Glu Asp Asn 
145                 150                 155                 160 


Glu Ala Asp Val Arg Lys Ser Ile Asp Asn Phe His Val Leu Lys Asn 
                165                 170                 175     


Lys Glu Glu Tyr Glu Ile Cys Asn Val Asp Asp Asn Cys Arg Ser Gln 
            180                 185                 190         


Asn Asn Lys Lys Lys Lys Asp Ile Val Thr Ile Leu Leu Lys Glu Leu 
        195                 200                 205             


Lys Asp Lys Ile Val Ser Cys Lys Asn Gln His Lys Ala Thr Lys Gly 
    210                 215                 220                 


Lys Glu Cys Cys Asp Lys Leu Pro Lys Ile Ala Asp Gly Asp Thr Ser 
225                 230                 235                 240 


Asp Asp Glu Glu Gln Glu Asp Glu Ala Pro Ala Pro Pro Lys Pro Lys 
                245                 250                 255     


Pro Pro Ser Thr Pro Asn Pro Cys Val Arg Lys Asp Gln Ser Gly Thr 
            260                 265                 270         


His Ile Val Ser Val Glu Asp Val Ala Glu Trp Met Gln Gly Val Thr 
        275                 280                 285             


His Asp Arg Val 
    290         


