                         SEQUENCE LISTING

<110>  Ionis Pharmaceuticals, Inc.
 
<120>  COMPOUNDS AND METHODS FOR MODULATING ANGIOTENSINOGEN EXPRESSION

<130>  BIOL0393WO

<150>  63/232,109
<151>  2021-08-11

<150>  63/115,499
<151>  2020-11-18

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  2587
<212>  DNA
<213>  Homo sapiens

<400>  1
atcccatgag cgggcagcag ggtcagaagt ggcccccgtg ttgcctaagc aagactctcc       60

cctgccctct gccctctgca cctccggcct gcatgtccct gtggcctctt gggggtacat      120

ctcccggggc tgggtcagaa ggcctgggtg gttggcctca ggctgtcaca cacctaggga      180

gatgctcccg tttctgggaa ccttggcccc gactcctgca aacttcggta aatgtgtaac      240

tcgaccctgc accggctcac tctgttcagc agtgaaactc tgcatcgatc actaagactt      300

cctggaagag gtcccagcgt gagtgtcgct tctggcatct gtccttctgg ccagcctgtg      360

gtctggccaa gtgatgtaac cctcctctcc agcctgtgca caggcagcct gggaacagct      420

ccatccccac ccctcagcta taaatagggc atcgtgaccc ggccggggga agaagctgcc      480

gttgttctgg gtactacagc agaagggtat gcggaagcga gcaccccagt ctgagatggc      540

tcctgccggt gtgagcctga gggccaccat cctctgcctc ctggcctggg ctggcctggc      600

tgcaggtgac cgggtgtaca tacacccctt ccacctcgtc atccacaatg agagtacctg      660

tgagcagctg gcaaaggcca atgccgggaa gcccaaagac cccaccttca tacctgctcc      720

aattcaggcc aagacatccc ctgtggatga aaaggcccta caggaccagc tggtgctagt      780

cgctgcaaaa cttgacaccg aagacaagtt gagggccgca atggtcggga tgctggccaa      840

cttcttgggc ttccgtatat atggcatgca cagtgagcta tggggcgtgg tccatggggc      900

caccgtcctc tccccaacgg ctgtctttgg caccctggcc tctctctatc tgggagcctt      960

ggaccacaca gctgacaggc tacaggcaat cctgggtgtt ccttggaagg acaagaactg     1020

cacctcccgg ctggatgcgc acaaggtcct gtctgccctg caggctgtac agggcctgct     1080

agtggcccag ggcagggctg atagccaggc ccagctgctg ctgtccacgg tggtgggcgt     1140

gttcacagcc ccaggcctgc acctgaagca gccgtttgtg cagggcctgg ctctctatac     1200

ccctgtggtc ctcccacgct ctctggactt cacagaactg gatgttgctg ctgagaagat     1260

tgacaggttc atgcaggctg tgacaggatg gaagactggc tgctccctga tgggagccag     1320

tgtggacagc accctggctt tcaacaccta cgtccacttc caagggaaga tgaagggctt     1380

ctccctgctg gccgagcccc aggagttctg ggtggacaac agcacctcag tgtctgttcc     1440

catgctctct ggcatgggca ccttccagca ctggagtgac atccaggaca acttctcggt     1500

gactcaagtg cccttcactg agagcgcctg cctgctgctg atccagcctc actatgcctc     1560

tgacctggac aaggtggagg gtctcacttt ccagcaaaac tccctcaact ggatgaagaa     1620

actatctccc cggaccatcc acctgaccat gccccaactg gtgctgcaag gatcttatga     1680

cctgcaggac ctgctcgccc aggctgagct gcccgccatt ctgcacaccg agctgaacct     1740

gcaaaaattg agcaatgacc gcatcagggt gggggaggtg ctgaacagca ttttttttga     1800

gcttgaagcg gatgagagag agcccacaga gtctacccaa cagcttaaca agcctgaggt     1860

cttggaggtg accctgaacc gcccattcct gtttgctgtg tatgatcaaa gcgccactgc     1920

cctgcacttc ctgggccgcg tggccaaccc gctgagcaca gcatgaggcc agggccccag     1980

aacacagtgc ctggcaaggc ctctgcccct ggcctttgag gcaaaggcca gcagcagata     2040

acaaccccgg acaaatcagc gatgtgtcac ccccagtctc ccaccttttc ttctaatgag     2100

tcgactttga gctggaaagc agccgtttct ccttggtcta agtgtgctgc atggagtgag     2160

cagtagaagc ctgcagcggc acaaatgcac ctcccagttt gctgggttta ttttagagaa     2220

tgggggtggg gaggcaagaa ccagtgttta gcgcgggact actgttccaa aaagaattcc     2280

aaccgaccag cttgtttgtg aaacaaaaaa gtgttccctt ttcaagttga gaacaaaaat     2340

tgggttttaa aattaaagta tacatttttg cattgccttc ggtttgtatt tagtgtcttg     2400

aatgtaagaa catgacctcc gtgtagtgtc tgtaatacct tagttttttc cacagatgct     2460

tgtgattttt gaacaatacg tgaaagatgc aagcacctga atttctgttt gaatgcggaa     2520

ccatagctgg ttatttctcc cttgtgttag taataaacgt cttgccacaa taagcctcca     2580

aaaaaaa                                                               2587


<210>  2
<211>  18000
<212>  DNA
<213>  Homo sapiens

<400>  2
cagagcaaga ccccaactct aaaacaacac acaaaaatac agccatttct cctgggtgaa       60

atgggggagc tcagactatt ttgttttatt tgtcaggagt ctaaagccca tgtgagccaa      120

cttaagaaaa ttctgtttgt atttgagtgt tctttattgg aaagaaatgg acttttccct      180

aatgagccca ttttacaaat cgagagctcc aaatgcccgg ttccagcccc catgatatag      240

atgggcagca atgaggacca gaaatgctgg gaagtgtcct tgtcatgcaa ggaaaacttg      300

gaacttcaag gatccatcat gggatgcagg acagtaggct ccacccctct tcctgctttc      360

cagtaaatga tgttcagggc tcacatgcct cttccaaggc atgatgtggg gttgcagttc      420

tgatcccagc agagaacaag gctcctgtga aacaattagt tttggctcag aggcaaaaaa      480

tggaaacccc attcctgtat ttacccttca ttctttcctt acctcataca gctggttcca      540

ggtttgattg catcatatac ataaataaat aatctgcttt cctggtttgg tttagttttg      600

ctggagagag gagtttatgt gttcatccca tgactagctg ggtggtcaag agattggaaa      660

gtaggagttc tagtttagac caagtctcat ctcagaaacc acagagtaga actgatccca      720

aacgtcatca tccctgtagg gaaaagaaag agagatcaga ctgttactgt gtctatatag      780

aaagggaaga cataagagac tccattttga aaaagagcta tactttaaac aattgctttg      840

ctgagatgtt gttaatttgt agctttgccc cagccacttt gacccaacct ggagctcaca      900

aaaacatgtg ttgtataaaa tcaaggttta agggatctag ggctgtgtca aagtggctgg      960

ggcaaagcta caaattaaca acatctcagc aaagcaattg tttaaagtac agctcttttt     1020

caaaatggag tctcttatgt cttccctttc tatatagaca cagtaacagt ctgatctctc     1080

ttttttttcc ctacatatcc caatagcacc tgcctgacta atacatcatg ctctgctgac     1140

tccatatgtg gctggtttcc tggatccgat tctgactgat ggtatctgtt ctcacgctgc     1200

taataaagac ataccagaga ctgggtaatt tataaagaaa aagaggttta atggacttat     1260

gtgttccacg tggctgggga ggcctcacaa tcatggtgga aggtgaagga ggagcaaaag     1320

cacatcttac atggtggctg gcaaaagaga gaaagcatgt tcaggggaac tcccctttat     1380

aaaaccatca gatctcatga gacttatgca ctatcacaag aacagcatca gaaagatcca     1440

ccctcatgat tcaattacct cccactgggt ccctcccatg acacatggga attatgggag     1500

ctacaattgg agatttgggt ggggacacag ccaaaccata tcagatggct tatttggttt     1560

ctatgtagaa cctctgcttt tcattcaaca gtcttcattt agccacagat aagctctgtc     1620

cctaacttcc actgatggaa tgtacacata agaaacttcc actgatggaa tgaacacaga     1680

aggtgcctac tgggaagaaa actggcctga atctgagctg ggtcaaatgt ctgcagtcag     1740

tttgaatggc tgctccttat gggaataatt tacattctca ataaaattct ctagcaattt     1800

tctgattgat tttaatgagc tttaaagcct tacgtagaag atcccccagc tgatagtcag     1860

ccttgggcat ggattaaggg cttttaacca atcttgcaac aagtttaagc agatattctt     1920

tattgggtcc aatctaacca aaattatttt cttatgttct ccccagtaac gtgtcattat     1980

taagagaagt ttggcttgct tagaggccaa atttagaggg tcctgaaatt ttattttctt     2040

ttacaccact ttccagcatg ttacctgatc agttgtttat tatctttgct gttgaatgga     2100

gtgatcattc caagggcccg aggcaggagg cccaggcaca gtggaaactc tcccaaagac     2160

caggatcttt gttttgttcc ctgacatatg ctgagcacca ggaatagtga gtgaatgaaa     2220

caaattgtga ggctttaaag agccgaaata tttaaacact gggcacaagg ttgttgctta     2280

atcagtgcta gatccttacc tcccccttgt gtccaggtgg acttgttact gcagttaaac     2340

cacttgctga tcctcaaaca actagttagt ggcacagcca ggcctaggac cccagtctct     2400

actgttccaa ctaacccatt cgcaggcagg agcactttga atggtctctt attttaaaaa     2460

aattaaatta aaattgtcta tttatttaga gacagagtct tactctgtag cccaggctcg     2520

agtgcagtgg tgcaatcata gctcactgta acctccatct cctggcctca aaaagtgttt     2580

gaattacaga tgcgaggcac tgtacctggc ccgaatgttc tgttcagaca aagccacctc     2640

taagtcgctg tggggcccca gacaagtgat ttttgaggag tccctatcta taggaacaaa     2700

gtaattaaaa aaatgtattt cagaatttac aggcccatgt gagatatgat ttttttaaat     2760

gaagatttag agtaatgggt aaaaaagagg tatttgtgtg tttgttgatt gttcagtcag     2820

tgaatgtaca gcttctgcct catatccagg caccatctct tcctgctctt tgttgttaaa     2880

tgttccattc ctgggtaatt tcatgtctgc catcgtggat atgccgtggc tccttgaacc     2940

tgcttgtgtt gaagcaggat cttccttcct gtcccttcag tgccctaata ccatgtattt     3000

aaggctggac acatcaccac tcccaacctg cctcacccac tgcgtcactt gtgatcactg     3060

gcttctggcg actctcacca aggtctctgt catgccctgt tataatgact acaaaagcaa     3120

gtcttaccta taggaaaata agaattataa cccttttact ggtcatgtga aacttaccat     3180

ttgcaatttg tacagcataa acacagaaca gcacatcttt caatgcctgc atcctgaagg     3240

cattttgttt gtgtctttca atctggctgt gctattgttg gtgtttaaca gtctccccag     3300

ctacactgga aacttccaga aggcactttt cacttgcttg tgtgttttcc ccagtgtcta     3360

ttagaggcct ttgcacaggg taggctcttt ggagcagctg aaggtcacac atcccatgag     3420

cgggcagcag ggtcagaagt ggcccccgtg ttgcctaagc aagactctcc cctgccctct     3480

gccctctgca cctccggcct gcatgtccct gtggcctctt gggggtacat ctcccggggc     3540

tgggtcagaa ggcctgggtg gttggcctca ggctgtcaca cacctaggga gatgctcccg     3600

tttctgggaa ccttggcccc gactcctgca aacttcggta aatgtgtaac tcgaccctgc     3660

accggctcac tctgttcagc agtgaaactc tgcatcgatc actaagactt cctggaagag     3720

gtcccagcgt gagtgtcgct tctggcatct gtccttctgg ccagcctgtg gtctggccaa     3780

gtgatgtaac cctcctctcc agcctgtgca caggcagcct gggaacagct ccatccccac     3840

ccctcagcta taaatagggc atcgtgaccc ggccggggga agaagctgcc gttgttctgg     3900

gtactacagc agaaggtaag ccgggggccc cctcagctcc ttctcggtct tgtctctctc     3960

agatgtaact gagctgtggg ctaggaggaa aaggccggga ggaggcacgg tgatgactga     4020

aaaacctctc ccctctcata agaccagtca tccggacgcg ggctttcccc cactcggtgc     4080

ccacctgggg tcttacagga ggagctgctc ctcctcagca ataggacaag atggtcaggt     4140

cttcctgctt ccgctgagaa aagttagggt cctcaggaac ggagcagact ggtacaggaa     4200

cagagtcatc atggccaaga gtccaccggg tcctcttgcc atcaggagga atagcagggc     4260

ttgtgcagga attggggctg gagggaaggg ccgggctcgg tcagtctcca gctgggatcc     4320

ccagagtggt caccctaccc ctccctcgag acagactgcc tgactgtgtg tcatcaggct     4380

ggtcaccatc tccctgaacc tcgatttgct cacctataaa atggaactaa taacgatgcc     4440

tgggctccct gtctcagggg ctctggtata gctgaagaga actaatataa catgaaagtg     4500

ctttctaagc tttgggataa gctaaaaggc agattccaat tttattcgag ggcagcgtag     4560

attggtgctt cagctcgtgg atgacagagt cagggggcct ggttctgagt cctagttctg     4620

tctcttccca gctgtgtgac gttgaacaag tcactggacc tctctgttcc tctgcaaaac     4680

agcatgaacc aattcattaa ctacttctcc aggatgcagt aggtcccagg gactatccta     4740

ggaatgtggg ctgtattagt aaacacaaca gcgggaaccc tgttccgggg ctcacattca     4800

catcagagca aacagacaaa gacgctggac agaataagtg cataactaca tggtacagag     4860

ggttataagg agggaaaagg ggagctggat gagagagttg agagtgcccg gtgtggtggg     4920

gaaagctgca gggtgaaata ctgcatcagg gaaacctcag ggaaggtgag gactatggtg     4980

aggtcagagg ggttgatatg agaacagtgc cctgcaaatg gcaggcacca caggagcatg     5040

agccgtcatc ttcaccttta gcattcagcc cgggagaagt agggagacat agaaggggca     5100

ggtgctggcc aagaggcagg ggcaggagag gagaaggcgg aggggcactc agggcgaggg     5160

tgtcaggccc gccaccccag agcaccatta ctcccaggac gcggctgcgt gcagacctgg     5220

aaccagccta gggagcagcc gcagatcaca actgagaaca aacgacagtc tctgcctcaa     5280

aaatggccca tggaattgcg tctctggaga cgctgcctga gcaggagcag cacagtgagc     5340

gggctgcatc gaccagcgcc atccaaaccc cgaacagttg gcgcttgtca ggcaggactt     5400

cccagcagtc ggttcccaca ggtttcccct gttgacctga tttgatgtga ctgtctagat     5460

taggtgtgaa ctggtggctt aggcttctct gcacagaaag gcctgcaagc agcagagaga     5520

gttttctgtt ccatttttcc atgtcatgtg gctcttcctg agaacagcgg atggagtcaa     5580

atgcatgggg agtggggtga gatggtagct gaggtcagaa tttggcattt gaatgactga     5640

agcagaacaa aacacaccag gtacttcagc agctgcaccg tgttgagggc aggtgctggt     5700

tacgggtctg ggtgagggaa gccagctgcc aatgtaagaa gaatgactgg gtatgcttag     5760

atgaagcaga aaaatctagg catcaaggtg gccttgagtc agtgatgaca cgctacagct     5820

ccaaggaagc ctggcctagc cctgggggga cagaaaaggc caagaagtga cgatattgca     5880

gtacaccccc ctccacaaga aatgagtgag atgtggtaca aaatgttaga attgaatgaa     5940

tcaatagaat aaacgttcat cccttcaatc aagaagagtc agatgaaatg aattagcagg     6000

gccagcccaa gaacctcttc tgggggtctc agggtagctt tcatttgtag cagctgaggc     6060

tgaagcccag ctgcaaggcc tttgagagaa cgtggtgctg gacccgtgtc tagggcaggg     6120

gttctaaacc ctgcttacat atcagagtca cctgagaatt ttctattttt tttttttttt     6180

ttttatacgt ggtcccagca cagactaagg aatccaacta tcattgggca agccatgcta     6240

ggtatgcatg cctttggggc tctgcagggg atagcgctat gcagggatgg ttgagagctg     6300

gttttggggt tgagacacgt gggaaatact tggactttgg gctgagcctg tggtgctcaa     6360

tcccggctgc atgttgggac cacagggaga tgacaaaacc atccccagcc ctcaccctag     6420

ggccctcgaa tgagcatctc aggggtctag gaggcctcca caaagaccta ctgattggca     6480

cacacttgtt tctctaggaa gagaacttac agctgcaggc aggagcatgt cttaatctgc     6540

ttgggctgcc ataagtacca cagactggga gggtttaaca acagaaatgt gttatctcac     6600

agttctggaa gctagaagcc tgggagccag ccatcagcag agttggtttc ctctgggtcc     6660

tctatccttg gcttgtagat ggccgtcttc tctctgtgtc cccacatggt cttccctctg     6720

tgtccccaca tggtcttccc tctgtgtgtg tccatgtcct catctcctct tctcataagg     6780

acacaggtca tattagatca gggctcaccc tcatggcctc attttaactt aatcatctct     6840

ttaaagatcc tgtctccaaa taatggtcac attctgaggt cctggggttg aggacttcaa     6900

cacgggcatt atggccgttg ggggaggtag gacataattc agctgatatt ggtgcatttt     6960

gcacttggat catgtagata ttttccatgg agctttgaat ccatttcttc ttttttttgt     7020

agacatgaat ggatttattc tgggctaaat ggtgacaggg aatattgaga caatgaaaga     7080

tctggttaga tggcacttaa aggtcagtta ataaccacct ttcacccttt gcaaaatgat     7140

atttcagggt atgcggaagc gagcacccca gtctgagatg gctcctgccg gtgtgagcct     7200

gagggccacc atcctctgcc tcctggcctg ggctggcctg gctgcaggtg accgggtgta     7260

catacacccc ttccacctcg tcatccacaa tgagagtacc tgtgagcagc tggcaaaggc     7320

caatgccggg aagcccaaag accccacctt catacctgct ccaattcagg ccaagacatc     7380

ccctgtggat gaaaaggccc tacaggacca gctggtgcta gtcgctgcaa aacttgacac     7440

cgaagacaag ttgagggccg caatggtcgg gatgctggcc aacttcttgg gcttccgtat     7500

atatggcatg cacagtgagc tatggggcgt ggtccatggg gccaccgtcc tctccccaac     7560

ggctgtcttt ggcaccctgg cctctctcta tctgggagcc ttggaccaca cagctgacag     7620

gctacaggca atcctgggtg ttccttggaa ggacaagaac tgcacctccc ggctggatgc     7680

gcacaaggtc ctgtctgccc tgcaggctgt acagggcctg ctagtggccc agggcagggc     7740

tgatagccag gcccagctgc tgctgtccac ggtggtgggc gtgttcacag ccccaggcct     7800

gcacctgaag cagccgtttg tgcagggcct ggctctctat acccctgtgg tcctcccacg     7860

ctctctggac ttcacagaac tggatgttgc tgctgagaag attgacaggt tcatgcaggc     7920

tgtgacagga tggaagactg gctgctccct gatgggagcc agtgtggaca gcaccctggc     7980

tttcaacacc tacgtccact tccaaggtaa ggcaaacctc tctgctggct ctggccctag     8040

gacttagtat ccaatgtgta gctgagatca gccagtcagg ccttggagat gggcaggggg     8100

cagccctgcg gacatacctg gtgaccaccc ttgagaagtg gggaagtggc tgctccgctg     8160

ggtccctgga tgggccgtcc acctcctgga cctgctgccc tactatgtgc acgactatac     8220

aacatccttt ttcttacatc atttaatccc cttatgatgt ggtgaagagg tatttgtgcc     8280

tttgtttacc agtgaagaaa tagagactcg gagaaacaaa gtgccttgct caagatggca     8340

cagccaccag tgggggtcct gggattgaaa cccacatctc ctggccccac agcccagttc     8400

tacactcaga agggtcaggt tcatatctct tgagaaggtc aggaactggg gtccctggcc     8460

catgcagaaa taagcaattg gcttgcttaa atccctttca tgttaggagg ggcattactg     8520

aaaaccctct actacaaaga ttgttgattt tttttttttt ttttattgag acagggtctt     8580

gttctgtcac ccaggctgca gtgtagtggt gccatcattg ctcactgtag ccttgaactc     8640

ctggcctcaa gcgatcctcc cacctctgcc ttccaaagtg ttgggattaa aggtgtgagc     8700

cactgcaccc agccacagat tgcttaaagc attcatttaa caaatacttg ttgaggattt     8760

gctacttgta agactttaag cctggcatct cagaggaggc cagaggaggg ctgtataggc     8820

cctgcctcca ggcttttaaa ggtcaatggg caaatgccta ggatttggag ctgcagggaa     8880

acgtgctcca caaggtaact cagggaagcc tcggggctct cagaggacag aggtcactgg     8940

ggagcggaga gcaggccttg cctggcagtg agggcaacag ggctggtgaa gctaggagca     9000

agcatgatga gcccagcctg cagagtttgg ggcaaggaac gaggatgggg cggttggctt     9060

ggcatgagtg ttgaaccaga aaatgggcct ggggagggca gagctggaga cactttgaac     9120

gccatgcttg gtaggtgtgg gaatggggac gcgttctgtt cagaggtcat cccggaagcc     9180

tgccgtgtgc agactggagg cagggaggat tgtttgaagg ttacgcaaga gtccaggcac     9240

acagtcacgg gaacacgtgc tcagggagca gctcggcaaa tccatgggtg gggtggggct     9300

gaggggtgtg tctaagagac actgaggagg ctctgtcaag atgttaacct cgtgagggac     9360

agagagccag gcgggaggtg aaagacaaga ctgtggagaa agaggttcag tggcgcatag     9420

tgatttttct taccacaaca acctccttga ggtctttccc ttcgggttca gggagaggtg     9480

atagatgggg ggattgctca gccctggcac tgactggtca caggggcaga ggccagcccg     9540

agggttgccc ggttgagggt ggcagcacac tgtgcagggc agagcaggga cacatggact     9600

tagcctgctg tccctaggag aagtgctggg aggagcgctc actgagaagg agggtcctgc     9660

agaaggcaaa ggcaagaaag ccagtggcat ctgaaatggg tctcccttcg aaagagagca     9720

catccacctg acccagaccg cagagccagg ccaggaggaa gaggaggaag aataaaaaag     9780

ccaaccacat cgggactcaa aggaagccca ggatcctcgc cggcctccac cgcatgctgc     9840

cctgaccctg ccccacttcc taactttgct ggcctcagtt tccgtcaaag gaggcagcca     9900

cttcctgccc acatggtctg tccagtgagg agatcggggg ctgtctcggg acctctaggt     9960

ttccctttag caatgatgtt ctatttacat gacctcagca ggcagctaga tgtgtcccac    10020

tagagaggac ctgaggatct ggggcctgat gggctccagg gtaccgtctg cccagtgctt    10080

gctgtgctcc tgagcatggg gcgctggccc tggtggtttc catgacacca ggtcctgact    10140

tgacctcgac agatttacct agcctccgga tgagaatggt gagctgtgca tgtcagacga    10200

gcagagggaa gacggcagcc actctcatgt caaatcccag cgtcttttgg gaggcagctt    10260

ccctttttta gtttagtttg ttggaagaaa agaattgtcc ctttcccccc tctaaactaa    10320

aagccttgcc agcccaggtg ggcagcaccg aggtccctgc agggaacgtg caaggggaac    10380

cctgcagttt cccgctcaca tgcccttccg agactgagtg ctccgaggac tgaggacgag    10440

aaatatgcca ggtctgccac tgccttctta cgagacccgg acccagggga ggcacagcca    10500

tgcccagctc ctgcctgcca gttctgtcct cccagctgcc ctactttcat gctgggacct    10560

ccaattcagt acaaagggag acctcactgt ttctgaacca tctctactca gactcccaag    10620

tgccacgtgc ccaggggact gttctgtgac aaacttatac acaacttcac cctattctcc    10680

taagaacaac cgcagaatag gcctttcagg atgagtggga ggacagccga gggcagggat    10740

gtgctagtgt aaggtcgagg cagagggtgg gctgctgtca tggaaagacc ccaggtaact    10800

gcgtcacaca caaatttgtg tccttctccc acaacgggct ctcccgagtt ctctgtcatc    10860

tgcacggccc tgtgagcagg aggggaaaca gagggctcac ccctgccccc aaggcccagt    10920

gtgcaaatcc attcatcaca acgaggttgt gtgagtctcc ccagtagcaa gggctgctga    10980

ggaatggagc cctcgtttcc ggggcctgcg tggcccactc tgtattctat gactgtgatg    11040

ggggagggtg ggggccacag gacagctggt gggctctgcc atggctgggg ctagacatgg    11100

attaaaaagt gagtatgagc aggggcctct aggagtggtg ggatagtgcg gtggtggcca    11160

catgtcattc tacgtgcgtc caaacctaca gaatgtaaaa caccaggagg gagactcaaa    11220

gaaaactatc aactttgagt gctgaggacg tgtcagtgta ggttcgtcag ttgcaacaaa    11280

tgggccacgc tggtgtgaga tgttgatcac gggggaggct gtgtagtggg ggacaagagt    11340

tatatgggaa ctttctgtac tttctgctcg attttgctgt gaacctaaag tcactctaaa    11400

aaataacatc tcttaaattt tttaaaaagt gagtgtgtca aaccacagcc tttgggtcag    11460

gacagttcta ggtttgagtt gacctggcag gtaccagtgg cttatgtccc ttaaggtgac    11520

agatgcaaaa cccccggttt ggtgcctggc atgttgtgtg tcttgcaggt ggcggttagg    11580

gctgcctcag tgaactcaaa tggctgcatt ttacaggaga aatatttgag ccacacttgc    11640

ggtcctgtgg ccaggagaat gcagagtggc ctgggggggg ccaaggaagg aggctgaggc    11700

agggcgaggg gcaggatctg ggcctttggt gtctgccagc cctcattcct gcccctgtct    11760

tgggtgactc ttccctccct gtctcctgtc tggatttcag ggaagatgaa gggcttctcc    11820

ctgctggccg agccccagga gttctgggtg gacaacagca cctcagtgtc tgttcccatg    11880

ctctctggca tgggcacctt ccagcactgg agtgacatcc aggacaactt ctcggtgact    11940

caagtgccct tcactgagag cgcctgcctg ctgctgatcc agcctcacta tgcctctgac    12000

ctggacaagg tggagggtct cactttccag caaaactccc tcaactggat gaagaaacta    12060

tctccccggt aggagcctcc cggtctcccc tggaatgtgg gagccacact gtcctgccca    12120

ggctgggggc ggggtgggga gtagacacac ctgagctgag ccttgggtgc agagcagggc    12180

agggccgcgg tggcacgggg ctgggcaggc ggcctgtgtg tctgtctacc agtcctctat    12240

ccagccagca cccagctctc cagttagtgt ctgtctttca agtgcaggca aggtaaagga    12300

ggagaggaag aatgcttttt ctacacttac acttgcctgg tagttttgga gggggagaaa    12360

acattgcaat ccgccctctg agagaggacc attttggtcc cacacctgac acacagcaca    12420

cctgtgacat ccaagagctt cttggaactg acttgccagg agggttcgga cttcgcgtga    12480

gcgggggtgg ggccttctca gggagcgtcc cttgactcca gaacgccctt gctggcggct    12540

ggcggctggg tggggatagg tgttgttagc tcctctttcc tgctgcaatt cctttccaca    12600

gagccctgga ctcaaactac acatcacccc agatcatcga ggcctggaaa tctgctccca    12660

gaggcaggca ttgagtgaca cgatggcttg acatcaactc tgggtgtttt ttatgtttta    12720

aaaattgtga tggtaaaata tacgtaacaa aatttgccat cgtaaccatt ttcgagtgca    12780

cagttcagtg gtactaggcc cattcacact gttgtgcagc catcaccccc gtccatctcc    12840

atttatcttc tcaacttccc aaactgaagc tctgtcctgc tgaaacacta actctccatt    12900

tccccttccc cttggccccg gcaaccacca cgatgtcctc gaggttcacc catgttgtag    12960

cacatgtcag aatgtccttc cttttgaagg ctgaataata ttccattgca tgtggttacc    13020

accttttgtg tatccactca tccatcgatg gacacgtggg ttgcttccac ctttgagctg    13080

ctgtgaatag tgcagtgtac cctgtaaaca tgggtgtact gtcagctctt ataagtgctt    13140

gatacatcac tggaaatgtc catgggctct gaaggatgcc aaaagatgga agaggctcta    13200

tacgaagatc aatcgagttg acatagcaac gtgtccagca cgaggttgac actgtaccct    13260

cctgcctctc tccttttcat gggtgtcatg tcatcaagaa cactgctgtg gcagtagtaa    13320

gacacagtgc attatttcag agaatagcat ttaaaaatta cccaagtaac acaccttcaa    13380

tgcagccaac ctaaaaacag aatgcaccaa aggacaacca ttcctaggtc ctcatcggta    13440

aatcttctat gtccctcaca tagtattgca aatgacatga aggattttta ttgtaggttt    13500

tgctgaaatt ttccccaagg gggaggatga cttagttggg tgatgggggg agcaaacatc    13560

cctgtcgtca gggttgggtg caaggagcat aagcctgcct ggcctctggg agagccctca    13620

ctgtgtggcc tggagccttc ctaactgtgc atcatctccc caggaccatc cacctgacca    13680

tgccccaact ggtgctgcaa ggatcttatg acctgcagga cctgctcgcc caggctgagc    13740

tgcccgccat tctgcacacc gagctgaacc tgcaaaaatt gagcaatgac cgcatcaggg    13800

tgggggaggt atgtgtgagc ctgtgtctgt gcctgacctg ggttccaagt gtgcacaggg    13860

tgggaggcat ggatgtaagg gacacagagg aggctatggg tggggccagc agggcaagag    13920

ggagcggaga gtagggccaa aggtgggaga gaagtagcca gagcattctg gggccttcca    13980

ggtgcagagc agcaaatccc tccccatccc tgctgtgcct cctcctgcta ggtgtgtgtt    14040

ccatggtcct gcttggcctt gccttgcctc agggtcctcc agggttccta tagtggagtt    14100

gaaaccggga tgaagacagc aagcacccct ggacctggtg ccctgggccc agccccttct    14160

tcagggaaat gctgagcagc agacagaatg tccccctgcc atgtggcacc atgcacatct    14220

gcagctacca aggatgtgcc ttgatgttct gggccctgtg ctcagtgctg gggagaaagt    14280

gggagttctt acgggggcca gcgggaagag ccctctgtgc taagttagct aagccctggc    14340

actggtgggc catggccaag ggagccagga attctgcctg ggacatcagg gcagaatgtg    14400

aagatgggag gatgtaaggg gtgtgttagg gaggagccgg catgtgagtt tggccattgt    14460

ggccaattaa cggtcatcta cacacagaca cacccttgcc tacactgagg ggcaggcata    14520

cactgtgcat cctcctggca ggctggaaaa tgtccccctc caggacagtg cacagcacag    14580

aggtcctgag cccaccccgg ccctctagcc ctcagcaccc tgggtcaccc agtgcgccct    14640

cagaatgatc ctgatgtctg ctgctttgca ggtgctgaac agcatttttt ttgagcttga    14700

agcggatgag agagagccca cagagtctac ccaacagctt aacaagcctg aggtcttgga    14760

ggtgaccctg aaccgcccat tcctgtttgc tgtgtatgat caaagcgcca ctgccctgca    14820

cttcctgggc cgcgtggcca acccgctgag cacagcatga ggccagggcc ccagaacaca    14880

gtgcctggca aggcctctgc ccctggcctt tgaggcaaag gccagcagca gataacaacc    14940

ccggacaaat cagcgatgtg tcacccccag tctcccacct tttcttctaa tgagtcgact    15000

ttgagctgga aagcagccgt ttctccttgg tctaagtgtg ctgcatggag tgagcagtag    15060

aagcctgcag cggcacaaat gcacctccca gtttgctggg tttattttag agaatggggg    15120

tggggaggca agaaccagtg tttagcgcgg gactactgtt ccaaaaagaa ttccaaccga    15180

ccagcttgtt tgtgaaacaa aaaagtgttc ccttttcaag ttgagaacaa aaattgggtt    15240

ttaaaattaa agtatacatt tttgcattgc cttcggtttg tatttagtgt cttgaatgta    15300

agaacatgac ctccgtgtag tgtctgtaat accttagttt tttccacaga tgcttgtgat    15360

ttttgaacaa tacgtgaaag atgcaagcac ctgaatttct gtttgaatgc ggaaccatag    15420

ctggttattt ctcccttgtg ttagtaataa acgtcttgcc acaataagcc tccaaaaatt    15480

ttatctttca tttagcagcc aaacagatgt atacaattca gcagatagac tgtgcaaacg    15540

aaagtgcttt cctggacttt ggatggaatt tccatgggag gtctgagcca gtacttagca    15600

gtcctttgaa gttttaggtg atgcttttct ctggacactt ccattggtaa gcagtggtgg    15660

ccatctgtgt gatggacagg gggcgggaag agggtgacag ggaaggcccc ataccccatg    15720

tggcacctgg gaaaggaacc aggcagatgg gacttcttcc gtcctggtga cacagggcca    15780

gactgctgct ggtattgtgc cccgggagtg gaaggtagag aaataaatct tcacaaataa    15840

atatttgcaa ttttccccca tctgttgagt gcctctgcct gctcctcctc gatgggatta    15900

ggcccacagt tcggaatctt ggggagagcc aaggaagcgg taggcaccca gtaggcccac    15960

ggccgtcggc tgatagcaat ggtgatgctg tcctacctac ttgtgtaagg cattcgatct    16020

tcctcccttc catacatatt gaaataaata agccgcgcaa tgtgttagct attgatcaga    16080

actaaagtga agtcagccac ggggattaca aatctcggct tctcccctca tgttcctgag    16140

agtcttcccc tggttttgaa cacatctccc tagctcgatg tcaaggtgag ggattctgtc    16200

ggcaacagca gtgcccttag ttgcttcgtc gtaactcccc gtcaccggtt ttattcagtt    16260

accttccagt cccactctca gagcttcctg gcttgttctg ctctcaaagc gggtagagct    16320

ggcacacatg gactctccga aacggctgca agatgccaag tttctcggaa gaactggaag    16380

cacagagacc agaagtgcct taaggtctcg ctattcagtg tggcgcttag accggcagtg    16440

gcggcagctg ccctgggagc ttgttagaat gtggcttctc acgcccctcc tggacctaca    16500

gagtcagaat ctgcagtttt acaggaggtc caggcttgga agttgctcgt agagacctga    16560

gacagcgcag ccacgtgctg gaaacaaagc atttaagttt gtgactttat tttaaaaggc    16620

agcaggcagt cgacaaacca atttcttcta cttagaggcg gcttcggctt ctggaagtcg    16680

ctaggagtat aaagttgcca accagcgctg ttctcccgct gttttctgtg cacttataaa    16740

tgggaagtta ggtcaggata gatctctcag ctattacaag gatacaaaat acgaacattc    16800

tacaagttac ttaacacaca cacacacaca cacacacaca cacacacaca caaaattaat    16860

tccacaggtc agtttctctg aaacattttt tcactaaatt ctaagtcttc ctggagttgc    16920

aagtgcctat ctcctagaca aggcaattac tcaccaacta aaatcactgt caatctgaga    16980

tttcggctgg gcatgagacc atggtcaggg gatgctttga acagcctctg aggaaattag    17040

tgagtttgaa aaatggaaag atttttatta ctcacttggc agtaaaacct gatggggaca    17100

gacgtcaggc tgtttaagat cctcagaaga aaaagttgat agtgtgaata ttcctaaatt    17160

tgccacacga agatgtacat gtgattataa ggtgctgttg cagaagcccc tgggggtgtt    17220

atgggatata cactatatgg gccactttac cttcctaaaa tctgaaaaac ttcaactact    17280

gaaacatgga ctgaaggttt tgaatagtgg atggtgaatt tgaataccat cccgtgtgat    17340

ttttttttct agcagacttt agttttttag agcagtttta agcccacacc aaaactgaga    17400

ggaagataca gcaatttctc atataccccc tactaccttc cagtctcccc cattattgac    17460

atcccccacc cagagtggtc catttcttac aacccacgaa cctacattga cacatcatta    17520

ttactcaacg tccatagttt acattagggt tggctcttgg tgttgtacat tctatgggtt    17580

tagacaattt tcaggagttt cactgacctg aaaatcctct gtgtccctcc tattcacccc    17640

tccttccctc ctaaccactg gtaaccaccg atcctattcc catcttctcc atagttttgc    17700

ctttcccacc caggatgtca tatagtggaa tcattcagta tgtggccttt ccagattagc    17760

ctctttcact tagtaatgtg catttaagtt tcctccatgt cttttcatga tcgctcattt    17820

cttttttatt gctaaatact atgccactgt ctggatgtgt cacagtttat ttattcacct    17880

actgaaggac atcttgcttg tttccaagtt gtggcaattg cgaattaagc tgctacagac    17940

acccatgtgt gggtttttgt gtggacatgt ttaccccaca caatttttaa agttgctcaa    18000


<210>  3
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  3
ccctgatggg agccagtgt                                                    19


<210>  4
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  4
agcagggaga agcccttca                                                    19


<210>  5
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Probe

<400>  5
ccctggcttt caacacctac gtccact                                           27


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  6
ggacaaggtg gagggtctca                                                   20


<210>  7
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  7
agatccttgc agcaccagtt g                                                 21


<210>  8
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Probe

<400>  8
atgaagaaac tatctccccg gaccatcca                                         29


<210>  9
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  9
gaaggtgaag gtcggagtc                                                    19


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  10
gaagatggtg atgggatttc                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Probe

<400>  11
caagcttccc gttctcagcc                                                   20


<210>  12
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
cgctgatttg tccggg                                                       16


<210>  13
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  13
tcggttggaa ttcttt                                                       16


<210>  14
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bases at these positions are RNA

<400>  14
tcggutggaa ttcttt                                                       16


<210>  15
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  15
gtcggttgga attctt                                                       16


<210>  16
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bases at these positions are RNA

<400>  16
ctcatugtgg atgacg                                                       16


<210>  17
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  17
ctcattgtgg atgacg                                                       16


<210>  18
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bases at these positions are RNA

<400>  18
tgaatuggag caggta                                                       16


<210>  19
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  19
tgaattggag caggta                                                       16


<210>  20
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  20
cggtgtcaag ttttgc                                                       16


<210>  21
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  21
gttgggtaga ctctgt                                                       16


<210>  22
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  22
gttggaattc tttttg                                                       16


<210>  23
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  23
gttaagctgt tgggta                                                       16


<210>  24
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bases at these positions are RNA

<400>  24
tgaautggag caggta                                                       16


<210>  25
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  25
ttgcaggttc agctcg                                                       16


<210>  26
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  26
ggtagactct gtgggc                                                       16


<210>  27
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  27
gttggaattc tttttg                                                       16


<210>  28
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  28
cacaaacaag ctggtcggtt                                                   20


