                         SEQUENCE LISTING

<110>  Merck Sharp & Dohme Corp.
       Abeywickrama, Pravien
       Depla, Erik
       Dombrecht, Bruno
       Gorman, Dan
       Houghton, Andrea
       Kastelein, Robert
       Kraus, Richard
       Majercak, John
       Pande, Kalyan
       Sharma, Sujata
 
<120>  NAV1.7 BINDERS

<130>  25127

<150>  63/115,878
<151>  2020-11-19

<150>  63/271,963
<151>  2021-10-26

<160>  603   

<170>  PatentIn version 3.5

<210>  1
<211>  1977
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 
                645                 650                 655     


Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 
            660                 665                 670         


Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 
        675                 680                 685             


Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 
    690                 695                 700                 


Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 
705                 710                 715                 720 


Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 
                725                 730                 735     


Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
            740                 745                 750         


Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 
        755                 760                 765             


Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 
    770                 775                 780                 


Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 
785                 790                 795                 800 


Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 
                805                 810                 815     


Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
            820                 825                 830         


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
        835                 840                 845             


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
    850                 855                 860                 


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
865                 870                 875                 880 


Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 
                885                 890                 895     


Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
            900                 905                 910         


Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
        915                 920                 925             


Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 
    930                 935                 940                 


Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
945                 950                 955                 960 


Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn 
                965                 970                 975     


Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 
            980                 985                 990         


Gln Thr Leu Arg Glu Phe Ile Leu  Lys Ala Phe Ser Lys  Lys Pro Lys 
        995                 1000                 1005             


Ile Ser  Arg Glu Ile Arg Gln  Ala Glu Asp Leu Asn  Thr Lys Lys 
    1010                 1015                 1020             


Glu Asn  Tyr Ile Ser Asn His  Thr Leu Ala Glu Met  Ser Lys Gly 
    1025                 1030                 1035             


His Asn  Phe Leu Lys Glu Lys  Asp Lys Ile Ser Gly  Phe Gly Ser 
    1040                 1045                 1050             


Ser Val  Asp Lys His Leu Met  Glu Asp Ser Asp Gly  Gln Ser Phe 
    1055                 1060                 1065             


Ile His  Asn Pro Ser Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly 
    1070                 1075                 1080             


Glu Ser  Asp Leu Glu Asn Met  Asn Ala Glu Glu Leu  Ser Ser Asp 
    1085                 1090                 1095             


Ser Asp  Ser Glu Tyr Ser Lys  Val Arg Leu Asn Arg  Ser Ser Ser 
    1100                 1105                 1110             


Ser Glu  Cys Ser Thr Val Asp  Asn Pro Leu Pro Gly  Glu Gly Glu 
    1115                 1120                 1125             


Glu Ala  Glu Ala Glu Pro Met  Asn Ser Asp Glu Pro  Glu Ala Cys 
    1130                 1135                 1140             


Phe Thr  Asp Gly Cys Val Arg  Arg Phe Ser Cys Cys  Gln Val Asn 
    1145                 1150                 1155             


Ile Glu  Ser Gly Lys Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr 
    1160                 1165                 1170             


Cys Tyr  Lys Ile Val Glu His  Ser Trp Phe Glu Ser  Phe Ile Val 
    1175                 1180                 1185             


Leu Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1190                 1195                 1200             


Tyr Ile  Glu Arg Lys Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala 
    1205                 1210                 1215             


Asp Lys  Ile Phe Thr Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys 
    1220                 1225                 1230             


Trp Ile  Ala Tyr Gly Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys 
    1235                 1240                 1245             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Leu Val  Thr Leu Val 
    1250                 1255                 1260             


Ala Asn  Thr Leu Gly Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu 
    1265                 1270                 1275             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1280                 1285                 1290             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro 
    1295                 1300                 1305             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1310                 1315                 1320             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu 
    1325                 1330                 1335             


Cys Ile  Asn Thr Thr Asp Gly  Ser Arg Phe Pro Ala  Ser Gln Val 
    1340                 1345                 1350             


Pro Asn  Arg Ser Glu Cys Phe  Ala Leu Met Asn Val  Ser Gln Asn 
    1355                 1360                 1365             


Val Arg  Trp Lys Asn Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu 
    1370                 1375                 1380             


Gly Tyr  Leu Ser Leu Leu Gln  Val Ala Thr Phe Lys  Gly Trp Thr 
    1385                 1390                 1395             


Ile Ile  Met Tyr Ala Ala Val  Asp Ser Val Asn Val  Asp Lys Gln 
    1400                 1405                 1410             


Pro Lys  Tyr Glu Tyr Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Val 
    1415                 1420                 1425             


Phe Ile  Ile Phe Gly Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly 
    1430                 1435                 1440             


Val Ile  Ile Asp Asn Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly 
    1445                 1450                 1455             


Gln Asp  Ile Phe Met Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala 
    1460                 1465                 1470             


Met Lys  Lys Leu Gly Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg 
    1475                 1480                 1485             


Pro Gly  Asn Lys Ile Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn 
    1490                 1495                 1500             


Gln Ala  Phe Asp Ile Ser Ile  Met Val Leu Ile Cys  Leu Asn Met 
    1505                 1510                 1515             


Val Thr  Met Met Val Glu Lys  Glu Gly Gln Ser Gln  His Met Thr 
    1520                 1525                 1530             


Glu Val  Leu Tyr Trp Ile Asn  Val Val Phe Ile Ile  Leu Phe Thr 
    1535                 1540                 1545             


Gly Glu  Cys Val Leu Lys Leu  Ile Ser Leu Arg His  Tyr Tyr Phe 
    1550                 1555                 1560             


Thr Val  Gly Trp Asn Ile Phe  Asp Phe Val Val Val  Ile Ile Ser 
    1565                 1570                 1575             


Ile Val  Gly Met Phe Leu Ala  Asp Leu Ile Glu Thr  Tyr Phe Val 
    1580                 1585                 1590             


Ser Pro  Thr Leu Phe Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg 
    1595                 1600                 1605             


Ile Leu  Arg Leu Val Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu 
    1610                 1615                 1620             


Phe Ala  Leu Met Met Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu 
    1625                 1630                 1635             


Leu Leu  Phe Leu Val Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser 
    1640                 1645                 1650             


Asn Phe  Ala Tyr Val Lys Lys  Glu Asp Gly Ile Asn  Asp Met Phe 
    1655                 1660                 1665             


Asn Phe  Glu Thr Phe Gly Asn  Ser Met Ile Cys Leu  Phe Gln Ile 
    1670                 1675                 1680             


Thr Thr  Ser Ala Gly Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn 
    1685                 1690                 1695             


Ser Lys  Pro Pro Asp Cys Asp  Pro Lys Lys Val His  Pro Gly Ser 
    1700                 1705                 1710             


Ser Val  Glu Gly Asp Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr 
    1715                 1720                 1725             


Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu Val Val  Val Asn Met 
    1730                 1735                 1740             


Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu 
    1745                 1750                 1755             


Ser Thr  Glu Pro Leu Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu 
    1760                 1765                 1770             


Val Trp  Glu Lys Phe Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Phe 
    1775                 1780                 1785             


Ser Lys  Leu Ser Asp Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu 
    1790                 1795                 1800             


Ile Ala  Lys Pro Asn Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro 
    1805                 1810                 1815             


Met Val  Ser Gly Asp Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala 
    1820                 1825                 1830             


Phe Thr  Lys Arg Val Leu Gly  Glu Ser Gly Glu Met  Asp Ser Leu 
    1835                 1840                 1845             


Arg Ser  Gln Met Glu Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys 
    1850                 1855                 1860             


Val Ser  Tyr Glu Pro Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu 
    1865                 1870                 1875             


Asp Val  Ser Ala Thr Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg 
    1880                 1885                 1890             


Leu Arg  Gln Asn Val Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp 
    1895                 1900                 1905             


Gly Asp  Arg Asp Asp Asp Leu  Leu Asn Lys Lys Asp  Met Ala Phe 
    1910                 1915                 1920             


Asp Asn  Val Asn Glu Asn Ser  Ser Pro Glu Lys Thr  Asp Ala Thr 
    1925                 1930                 1935             


Ser Ser  Thr Thr Ser Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Asp Lys  Glu Lys Tyr Glu Gln  Asp Arg Thr Glu Lys  Glu Asp Lys 
    1955                 1960                 1965             


Gly Lys  Asp Ser Lys Glu Ser  Lys Lys 
    1970                 1975         


<210>  2
<211>  1977
<212>  PRT
<213>  Macaca mulatta

<400>  2

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 
                645                 650                 655     


Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 
            660                 665                 670         


Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 
        675                 680                 685             


Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 
    690                 695                 700                 


Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 
705                 710                 715                 720 


Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 
                725                 730                 735     


Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
            740                 745                 750         


Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 
        755                 760                 765             


Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 
    770                 775                 780                 


Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 
785                 790                 795                 800 


Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 
                805                 810                 815     


Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
            820                 825                 830         


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
        835                 840                 845             


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
    850                 855                 860                 


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
865                 870                 875                 880 


Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 
                885                 890                 895     


Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
            900                 905                 910         


Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
        915                 920                 925             


Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 
    930                 935                 940                 


Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
945                 950                 955                 960 


Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn 
                965                 970                 975     


Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 
            980                 985                 990         


Gln Thr Leu Arg Glu Phe Ile Leu  Lys Ala Phe Ser Lys  Lys Pro Lys 
        995                 1000                 1005             


Ile Ser  Arg Glu Ile Arg Gln  Ala Glu Asp Leu Asn  Thr Lys Lys 
    1010                 1015                 1020             


Glu Asn  Tyr Ile Ser Asn His  Thr Leu Ala Glu Met  Ser Lys Gly 
    1025                 1030                 1035             


His Asn  Phe Leu Lys Glu Lys  Asp Lys Ile Ser Gly  Phe Gly Ser 
    1040                 1045                 1050             


Ser Val  Asp Lys His Leu Met  Glu Asp Ser Asp Gly  Gln Ser Phe 
    1055                 1060                 1065             


Ile His  Asn Pro Ser Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly 
    1070                 1075                 1080             


Glu Ser  Asp Leu Glu Asn Met  Asn Ala Glu Glu Leu  Ser Ser Asp 
    1085                 1090                 1095             


Ser Asp  Ser Glu Tyr Ser Lys  Val Arg Leu Asn Arg  Ser Ser Ser 
    1100                 1105                 1110             


Ser Glu  Cys Ser Thr Val Asp  Asn Pro Leu Pro Gly  Glu Gly Glu 
    1115                 1120                 1125             


Glu Ala  Glu Ala Glu Pro Met  Asn Ser Asp Glu Pro  Glu Ala Cys 
    1130                 1135                 1140             


Phe Thr  Asp Gly Cys Val Arg  Arg Phe Ser Cys Cys  Gln Val Asn 
    1145                 1150                 1155             


Ile Glu  Ser Gly Lys Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr 
    1160                 1165                 1170             


Cys Tyr  Lys Ile Val Glu His  Ser Trp Phe Glu Ser  Phe Ile Val 
    1175                 1180                 1185             


Leu Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1190                 1195                 1200             


Tyr Ile  Glu Arg Lys Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala 
    1205                 1210                 1215             


Asp Lys  Ile Phe Thr Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys 
    1220                 1225                 1230             


Trp Ile  Ala Tyr Gly Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys 
    1235                 1240                 1245             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Leu Val  Thr Leu Val 
    1250                 1255                 1260             


Ala Asn  Thr Leu Gly Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu 
    1265                 1270                 1275             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1280                 1285                 1290             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro 
    1295                 1300                 1305             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1310                 1315                 1320             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu 
    1325                 1330                 1335             


Cys Ile  Asn Thr Thr Asp Gly  Ser Arg Phe Pro Ala  Ser Gln Val 
    1340                 1345                 1350             


Pro Asn  Arg Ser Glu Cys Phe  Ala Leu Met Asn Val  Ser Gln Asn 
    1355                 1360                 1365             


Val Arg  Trp Lys Asn Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu 
    1370                 1375                 1380             


Gly Tyr  Leu Ser Leu Leu Gln  Val Ala Thr Phe Lys  Gly Trp Thr 
    1385                 1390                 1395             


Ile Ile  Met Tyr Ala Ala Val  Asp Ser Val Asn Val  Asp Lys Gln 
    1400                 1405                 1410             


Pro Lys  Tyr Glu Tyr Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Val 
    1415                 1420                 1425             


Phe Ile  Ile Phe Gly Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly 
    1430                 1435                 1440             


Val Ile  Ile Asp Asn Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly 
    1445                 1450                 1455             


Gln Asp  Ile Phe Met Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala 
    1460                 1465                 1470             


Met Lys  Lys Leu Gly Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg 
    1475                 1480                 1485             


Pro Gly  Asn Lys Ile Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn 
    1490                 1495                 1500             


Gln Ala  Phe Asp Ile Ser Ile  Met Val Leu Ile Cys  Leu Asn Met 
    1505                 1510                 1515             


Val Thr  Met Met Val Glu Lys  Glu Gly Gln Ser Gln  His Met Thr 
    1520                 1525                 1530             


Glu Val  Leu Tyr Trp Ile Asn  Val Val Phe Ile Ile  Leu Phe Thr 
    1535                 1540                 1545             


Gly Glu  Cys Val Leu Lys Leu  Ile Ser Leu Arg His  Tyr Tyr Phe 
    1550                 1555                 1560             


Thr Val  Gly Trp Asn Ile Phe  Asp Phe Val Val Val  Ile Ile Ser 
    1565                 1570                 1575             


Ile Val  Gly Met Phe Leu Ala  Asp Leu Ile Glu Thr  Tyr Phe Val 
    1580                 1585                 1590             


Ser Pro  Thr Leu Phe Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg 
    1595                 1600                 1605             


Ile Leu  Arg Leu Val Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu 
    1610                 1615                 1620             


Phe Ala  Leu Met Met Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu 
    1625                 1630                 1635             


Leu Leu  Phe Leu Val Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser 
    1640                 1645                 1650             


Asn Phe  Ala Tyr Val Lys Lys  Glu Asp Gly Ile Asn  Asp Met Phe 
    1655                 1660                 1665             


Asn Phe  Glu Thr Phe Gly Asn  Ser Met Ile Cys Leu  Phe Gln Ile 
    1670                 1675                 1680             


Thr Thr  Ser Ala Gly Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn 
    1685                 1690                 1695             


Ser Lys  Pro Pro Asp Cys Asp  Pro Lys Lys Val His  Pro Gly Ser 
    1700                 1705                 1710             


Ser Val  Glu Gly Asp Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr 
    1715                 1720                 1725             


Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu Val Val  Val Asn Met 
    1730                 1735                 1740             


Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu 
    1745                 1750                 1755             


Ser Thr  Glu Pro Leu Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu 
    1760                 1765                 1770             


Val Trp  Glu Lys Phe Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Phe 
    1775                 1780                 1785             


Ser Lys  Leu Ser Asp Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu 
    1790                 1795                 1800             


Ile Ala  Lys Pro Asn Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro 
    1805                 1810                 1815             


Met Val  Ser Gly Asp Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala 
    1820                 1825                 1830             


Phe Thr  Lys Arg Val Leu Gly  Glu Ser Gly Glu Met  Asp Ser Leu 
    1835                 1840                 1845             


Arg Ser  Gln Met Glu Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys 
    1850                 1855                 1860             


Val Ser  Tyr Glu Pro Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu 
    1865                 1870                 1875             


Asp Val  Ser Ala Thr Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg 
    1880                 1885                 1890             


Leu Arg  Gln Asn Val Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp 
    1895                 1900                 1905             


Gly Asp  Arg Asp Asp Asp Leu  Leu Asn Lys Lys Asp  Met Ala Phe 
    1910                 1915                 1920             


Asp Asn  Val Asn Glu Asn Ser  Ser Pro Glu Lys Thr  Asp Ala Thr 
    1925                 1930                 1935             


Ser Ser  Thr Thr Ser Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Asp Lys  Glu Lys Tyr Glu Gln  Asp Arg Thr Glu Lys  Glu Asp Lys 
    1955                 1960                 1965             


Gly Lys  Asp Ser Lys Glu Ser  Lys Lys 
    1970                 1975         


<210>  3
<211>  2694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav1.7-beta1-beta2-beta3 viral P2A

<400>  3

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 
                645                 650                 655     


Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 
            660                 665                 670         


Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 
        675                 680                 685             


Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 
    690                 695                 700                 


Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 
705                 710                 715                 720 


Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 
                725                 730                 735     


Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
            740                 745                 750         


Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 
        755                 760                 765             


Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 
    770                 775                 780                 


Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 
785                 790                 795                 800 


Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 
                805                 810                 815     


Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
            820                 825                 830         


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
        835                 840                 845             


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
    850                 855                 860                 


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
865                 870                 875                 880 


Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 
                885                 890                 895     


Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
            900                 905                 910         


Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
        915                 920                 925             


Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 
    930                 935                 940                 


Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
945                 950                 955                 960 


Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn 
                965                 970                 975     


Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 
            980                 985                 990         


Gln Thr Leu Arg Glu Phe Ile Leu  Lys Ala Phe Ser Lys  Lys Pro Lys 
        995                 1000                 1005             


Ile Ser  Arg Glu Ile Arg Gln  Ala Glu Asp Leu Asn  Thr Lys Lys 
    1010                 1015                 1020             


Glu Asn  Tyr Ile Ser Asn His  Thr Leu Ala Glu Met  Ser Lys Gly 
    1025                 1030                 1035             


His Asn  Phe Leu Lys Glu Lys  Asp Lys Ile Ser Gly  Phe Gly Ser 
    1040                 1045                 1050             


Ser Val  Asp Lys His Leu Met  Glu Asp Ser Asp Gly  Gln Ser Phe 
    1055                 1060                 1065             


Ile His  Asn Pro Ser Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly 
    1070                 1075                 1080             


Glu Ser  Asp Leu Glu Asn Met  Asn Ala Glu Glu Leu  Ser Ser Asp 
    1085                 1090                 1095             


Ser Asp  Ser Glu Tyr Ser Lys  Val Arg Leu Asn Arg  Ser Ser Ser 
    1100                 1105                 1110             


Ser Glu  Cys Ser Thr Val Asp  Asn Pro Leu Pro Gly  Glu Gly Glu 
    1115                 1120                 1125             


Glu Ala  Glu Ala Glu Pro Met  Asn Ser Asp Glu Pro  Glu Ala Cys 
    1130                 1135                 1140             


Phe Thr  Asp Gly Cys Val Arg  Arg Phe Ser Cys Cys  Gln Val Asn 
    1145                 1150                 1155             


Ile Glu  Ser Gly Lys Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr 
    1160                 1165                 1170             


Cys Tyr  Lys Ile Val Glu His  Ser Trp Phe Glu Ser  Phe Ile Val 
    1175                 1180                 1185             


Leu Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1190                 1195                 1200             


Tyr Ile  Glu Arg Lys Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala 
    1205                 1210                 1215             


Asp Lys  Ile Phe Thr Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys 
    1220                 1225                 1230             


Trp Ile  Ala Tyr Gly Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys 
    1235                 1240                 1245             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Leu Val  Thr Leu Val 
    1250                 1255                 1260             


Ala Asn  Thr Leu Gly Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu 
    1265                 1270                 1275             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1280                 1285                 1290             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro 
    1295                 1300                 1305             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1310                 1315                 1320             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu 
    1325                 1330                 1335             


Cys Ile  Asn Thr Thr Asp Gly  Ser Arg Phe Pro Ala  Ser Gln Val 
    1340                 1345                 1350             


Pro Asn  Arg Ser Glu Cys Phe  Ala Leu Met Asn Val  Ser Gln Asn 
    1355                 1360                 1365             


Val Arg  Trp Lys Asn Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu 
    1370                 1375                 1380             


Gly Tyr  Leu Ser Leu Leu Gln  Val Ala Thr Phe Lys  Gly Trp Thr 
    1385                 1390                 1395             


Ile Ile  Met Tyr Ala Ala Val  Asp Ser Val Asn Val  Asp Lys Gln 
    1400                 1405                 1410             


Pro Lys  Tyr Glu Tyr Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Val 
    1415                 1420                 1425             


Phe Ile  Ile Phe Gly Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly 
    1430                 1435                 1440             


Val Ile  Ile Asp Asn Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly 
    1445                 1450                 1455             


Gln Asp  Ile Phe Met Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala 
    1460                 1465                 1470             


Met Lys  Lys Leu Gly Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg 
    1475                 1480                 1485             


Pro Gly  Asn Lys Ile Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn 
    1490                 1495                 1500             


Gln Ala  Phe Asp Ile Ser Ile  Met Val Leu Ile Cys  Leu Asn Met 
    1505                 1510                 1515             


Val Thr  Met Met Val Glu Lys  Glu Gly Gln Ser Gln  His Met Thr 
    1520                 1525                 1530             


Glu Val  Leu Tyr Trp Ile Asn  Val Val Phe Ile Ile  Leu Phe Thr 
    1535                 1540                 1545             


Gly Glu  Cys Val Leu Lys Leu  Ile Ser Leu Arg His  Tyr Tyr Phe 
    1550                 1555                 1560             


Thr Val  Gly Trp Asn Ile Phe  Asp Phe Val Val Val  Ile Ile Ser 
    1565                 1570                 1575             


Ile Val  Gly Met Phe Leu Ala  Asp Leu Ile Glu Thr  Tyr Phe Val 
    1580                 1585                 1590             


Ser Pro  Thr Leu Phe Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg 
    1595                 1600                 1605             


Ile Leu  Arg Leu Val Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu 
    1610                 1615                 1620             


Phe Ala  Leu Met Met Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu 
    1625                 1630                 1635             


Leu Leu  Phe Leu Val Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser 
    1640                 1645                 1650             


Asn Phe  Ala Tyr Val Lys Lys  Glu Asp Gly Ile Asn  Asp Met Phe 
    1655                 1660                 1665             


Asn Phe  Glu Thr Phe Gly Asn  Ser Met Ile Cys Leu  Phe Gln Ile 
    1670                 1675                 1680             


Thr Thr  Ser Ala Gly Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn 
    1685                 1690                 1695             


Ser Lys  Pro Pro Asp Cys Asp  Pro Lys Lys Val His  Pro Gly Ser 
    1700                 1705                 1710             


Ser Val  Glu Gly Asp Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr 
    1715                 1720                 1725             


Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu Val Val  Val Asn Met 
    1730                 1735                 1740             


Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu 
    1745                 1750                 1755             


Ser Thr  Glu Pro Leu Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu 
    1760                 1765                 1770             


Val Trp  Glu Lys Phe Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Phe 
    1775                 1780                 1785             


Ser Lys  Leu Ser Asp Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu 
    1790                 1795                 1800             


Ile Ala  Lys Pro Asn Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro 
    1805                 1810                 1815             


Met Val  Ser Gly Asp Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala 
    1820                 1825                 1830             


Phe Thr  Lys Arg Val Leu Gly  Glu Ser Gly Glu Met  Asp Ser Leu 
    1835                 1840                 1845             


Arg Ser  Gln Met Glu Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys 
    1850                 1855                 1860             


Val Ser  Tyr Glu Pro Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu 
    1865                 1870                 1875             


Asp Val  Ser Ala Thr Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg 
    1880                 1885                 1890             


Leu Arg  Gln Asn Val Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp 
    1895                 1900                 1905             


Gly Asp  Arg Asp Asp Asp Leu  Leu Asn Lys Lys Asp  Met Ala Phe 
    1910                 1915                 1920             


Asp Asn  Val Asn Glu Asn Ser  Ser Pro Glu Lys Thr  Asp Ala Thr 
    1925                 1930                 1935             


Ser Ser  Thr Thr Ser Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Asp Lys  Glu Lys Tyr Glu Gln  Asp Arg Thr Glu Lys  Glu Asp Lys 
    1955                 1960                 1965             


Gly Lys  Asp Ser Lys Glu Ser  Lys Lys Ser Gly Arg  Gly Ser Gly 
    1970                 1975                 1980             


Ala Thr  Asn Phe Ser Leu Leu  Lys Gln Ala Gly Asp  Val Glu Glu 
    1985                 1990                 1995             


Asn Pro  Gly Pro Met Gly Arg  Leu Leu Ala Leu Val  Val Gly Ala 
    2000                 2005                 2010             


Ala Leu  Val Ser Ser Ala Cys  Gly Gly Cys Val Glu  Val Asp Ser 
    2015                 2020                 2025             


Glu Thr  Glu Ala Val Tyr Gly  Met Thr Phe Lys Ile  Leu Cys Ile 
    2030                 2035                 2040             


Ser Cys  Lys Arg Arg Ser Glu  Thr Asn Ala Glu Thr  Phe Thr Glu 
    2045                 2050                 2055             


Trp Thr  Phe Arg Gln Lys Gly  Thr Glu Glu Phe Val  Lys Ile Leu 
    2060                 2065                 2070             


Arg Tyr  Glu Asn Glu Val Leu  Gln Leu Glu Glu Asp  Glu Arg Phe 
    2075                 2080                 2085             


Glu Gly  Arg Val Val Trp Asn  Gly Ser Arg Gly Thr  Lys Asp Leu 
    2090                 2095                 2100             


Gln Asp  Leu Ser Ile Phe Ile  Thr Asn Val Thr Tyr  Asn His Ser 
    2105                 2110                 2115             


Gly Asp  Tyr Glu Cys His Val  Tyr Arg Leu Leu Phe  Phe Glu Asn 
    2120                 2125                 2130             


Tyr Glu  His Asn Thr Ser Val  Val Lys Lys Ile His  Ile Glu Val 
    2135                 2140                 2145             


Val Asp  Lys Ala Asn Arg Asp  Met Ala Ser Ile Val  Ser Glu Ile 
    2150                 2155                 2160             


Met Met  Tyr Val Leu Ile Val  Val Leu Thr Ile Trp  Leu Val Ala 
    2165                 2170                 2175             


Glu Met  Ile Tyr Cys Tyr Lys  Lys Ile Ala Ala Ala  Thr Glu Thr 
    2180                 2185                 2190             


Ala Ala  Gln Glu Asn Ala Ser  Glu Tyr Leu Ala Ile  Thr Ser Glu 
    2195                 2200                 2205             


Ser Lys  Glu Asn Cys Thr Gly  Val Gln Val Ala Glu  Gly Ser Gly 
    2210                 2215                 2220             


Ala Thr  Asn Phe Ser Leu Leu  Lys Gln Ala Gly Asp  Val Glu Glu 
    2225                 2230                 2235             


Asn Pro  Gly Pro Met His Arg  Asp Ala Trp Leu Pro  Arg Pro Ala 
    2240                 2245                 2250             


Phe Ser  Leu Thr Gly Leu Ser  Leu Phe Phe Ser Leu  Val Pro Pro 
    2255                 2260                 2265             


Gly Arg  Ser Met Glu Val Thr  Val Pro Ala Thr Leu  Asn Val Leu 
    2270                 2275                 2280             


Asn Gly  Ser Asp Ala Arg Leu  Pro Cys Thr Phe Asn  Ser Cys Tyr 
    2285                 2290                 2295             


Thr Val  Asn His Lys Gln Phe  Ser Leu Asn Trp Thr  Tyr Gln Glu 
    2300                 2305                 2310             


Cys Asn  Asn Cys Ser Glu Glu  Met Phe Leu Gln Phe  Arg Met Lys 
    2315                 2320                 2325             


Ile Ile  Asn Leu Lys Leu Glu  Arg Phe Gln Asp Arg  Val Glu Phe 
    2330                 2335                 2340             


Ser Gly  Asn Pro Ser Lys Tyr  Asp Val Ser Val Met  Leu Arg Asn 
    2345                 2350                 2355             


Val Gln  Pro Glu Asp Glu Gly  Ile Tyr Asn Cys Tyr  Ile Met Asn 
    2360                 2365                 2370             


Pro Pro  Asp Arg His Arg Gly  His Gly Lys Ile His  Leu Gln Val 
    2375                 2380                 2385             


Leu Met  Glu Glu Pro Pro Glu  Arg Asp Ser Thr Val  Ala Val Ile 
    2390                 2395                 2400             


Val Gly  Ala Ser Val Gly Gly  Phe Leu Ala Val Val  Ile Leu Val 
    2405                 2410                 2415             


Leu Met  Val Val Lys Cys Val  Arg Arg Lys Lys Glu  Gln Lys Leu 
    2420                 2425                 2430             


Ser Thr  Asp Asp Leu Lys Thr  Glu Glu Glu Gly Lys  Thr Asp Gly 
    2435                 2440                 2445             


Glu Gly  Asn Pro Asp Asp Gly  Ala Lys Gly Ser Gly  Ala Thr Asn 
    2450                 2455                 2460             


Phe Ser  Leu Leu Lys Gln Ala  Gly Asp Val Glu Glu  Asn Pro Gly 
    2465                 2470                 2475             


Pro Met  Pro Ala Phe Asn Arg  Leu Phe Pro Leu Ala  Ser Leu Val 
    2480                 2485                 2490             


Leu Ile  Tyr Trp Val Ser Val  Cys Phe Pro Val Cys  Val Glu Val 
    2495                 2500                 2505             


Pro Ser  Glu Thr Glu Ala Val  Gln Gly Asn Pro Met  Lys Leu Arg 
    2510                 2515                 2520             


Cys Ile  Ser Cys Met Lys Arg  Glu Glu Val Glu Ala  Thr Thr Val 
    2525                 2530                 2535             


Val Glu  Trp Phe Tyr Arg Pro  Glu Gly Gly Lys Asp  Phe Leu Ile 
    2540                 2545                 2550             


Tyr Glu  Tyr Arg Asn Gly His  Gln Glu Val Glu Ser  Pro Phe Gln 
    2555                 2560                 2565             


Gly Arg  Leu Gln Trp Asn Gly  Ser Lys Asp Leu Gln  Asp Val Ser 
    2570                 2575                 2580             


Ile Thr  Val Leu Asn Val Thr  Leu Asn Asp Ser Gly  Leu Tyr Thr 
    2585                 2590                 2595             


Cys Asn  Val Ser Arg Glu Phe  Glu Phe Glu Ala His  Arg Pro Phe 
    2600                 2605                 2610             


Val Lys  Thr Thr Arg Leu Ile  Pro Leu Arg Val Thr  Glu Glu Ala 
    2615                 2620                 2625             


Gly Glu  Asp Phe Thr Ser Val  Val Ser Glu Ile Met  Met Tyr Ile 
    2630                 2635                 2640             


Leu Leu  Val Phe Leu Thr Leu  Trp Leu Leu Ile Glu  Met Ile Tyr 
    2645                 2650                 2655             


Cys Tyr  Arg Lys Val Ser Lys  Ala Glu Glu Ala Ala  Gln Glu Asn 
    2660                 2665                 2670             


Ala Ser  Asp Tyr Leu Ala Ile  Pro Ser Glu Asn Lys  Glu Asn Ser 
    2675                 2680                 2685             


Ala Val  Pro Val Glu Glu 
    2690                 


<210>  4
<211>  2694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rhNav1.7-beta1-beta2-beta3 viral P2A

<400>  4

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Ile Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Val Gln Asn Ser Leu Val Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Met Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Asp Ser Glu Glu Asn Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Ser Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Ile Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 
                645                 650                 655     


Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 
            660                 665                 670         


Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 
        675                 680                 685             


Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 
    690                 695                 700                 


Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 
705                 710                 715                 720 


Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 
                725                 730                 735     


Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
            740                 745                 750         


Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 
        755                 760                 765             


Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 
    770                 775                 780                 


Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 
785                 790                 795                 800 


Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 
                805                 810                 815     


Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
            820                 825                 830         


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
        835                 840                 845             


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
    850                 855                 860                 


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
865                 870                 875                 880 


Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 
                885                 890                 895     


Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
            900                 905                 910         


Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
        915                 920                 925             


Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 
    930                 935                 940                 


Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
945                 950                 955                 960 


Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn 
                965                 970                 975     


Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 
            980                 985                 990         


Gln Thr Leu Arg Glu Phe Ile Leu  Lys Thr Phe Ser Lys  Lys Pro Lys 
        995                 1000                 1005             


Ile Ser  Arg Glu Ile Arg Gln  Thr Glu Asp Leu Asn  Thr Lys Lys 
    1010                 1015                 1020             


Glu Asn  Tyr Ile Ser Asn Tyr  Thr Leu Ala Glu Met  Ser Lys Gly 
    1025                 1030                 1035             


His Asn  Phe Leu Lys Glu Lys  Asp Lys Ile Ser Gly  Phe Gly Ser 
    1040                 1045                 1050             


Cys Val  Asp Lys Tyr Leu Met  Glu Asp Ser Asp Gly  Gln Ser Phe 
    1055                 1060                 1065             


Ile His  Asn Pro Ser Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly 
    1070                 1075                 1080             


Glu Ser  Asp Leu Glu Asn Met  Asn Thr Glu Glu Leu  Ser Ser Asp 
    1085                 1090                 1095             


Ser Asp  Ser Glu Tyr Ser Lys  Val Arg Leu Asn Gln  Ser Ser Ser 
    1100                 1105                 1110             


Ser Glu  Cys Ser Thr Val Asp  Asn Pro Leu Pro Gly  Glu Gly Glu 
    1115                 1120                 1125             


Glu Ala  Glu Ala Glu Pro Met  Asn Ser Asp Glu Pro  Glu Ala Cys 
    1130                 1135                 1140             


Phe Thr  Asp Gly Cys Val Arg  Arg Phe Ser Cys Cys  Gln Val Asn 
    1145                 1150                 1155             


Ile Glu  Ser Gly Lys Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr 
    1160                 1165                 1170             


Cys Tyr  Lys Ile Val Glu His  Ser Trp Phe Glu Ser  Phe Ile Val 
    1175                 1180                 1185             


Leu Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1190                 1195                 1200             


Tyr Ile  Glu Arg Lys Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala 
    1205                 1210                 1215             


Asp Lys  Ile Phe Thr Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys 
    1220                 1225                 1230             


Trp Ile  Ala Tyr Gly Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys 
    1235                 1240                 1245             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Leu Val  Thr Leu Val 
    1250                 1255                 1260             


Ala Asn  Thr Leu Gly Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu 
    1265                 1270                 1275             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1280                 1285                 1290             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro 
    1295                 1300                 1305             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1310                 1315                 1320             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu 
    1325                 1330                 1335             


Cys Ile  Asn Thr Thr Asp Gly  Ser Arg Phe Pro Ala  Ser Gln Val 
    1340                 1345                 1350             


Pro Asn  Arg Ser Glu Cys Phe  Ala Leu Met Asn Val  Ser Gln Asn 
    1355                 1360                 1365             


Val Arg  Trp Lys Asn Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu 
    1370                 1375                 1380             


Gly Tyr  Leu Ser Leu Leu Gln  Val Ala Thr Phe Lys  Gly Trp Thr 
    1385                 1390                 1395             


Ile Ile  Met Tyr Ala Ala Val  Asp Ser Val Asn Val  Asp Lys Gln 
    1400                 1405                 1410             


Pro Lys  Tyr Glu Tyr Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Ile 
    1415                 1420                 1425             


Phe Ile  Ile Phe Gly Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly 
    1430                 1435                 1440             


Val Ile  Ile Asp Asn Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly 
    1445                 1450                 1455             


Gln Asp  Ile Phe Met Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala 
    1460                 1465                 1470             


Met Lys  Lys Leu Gly Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg 
    1475                 1480                 1485             


Pro Gly  Asn Lys Ile Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn 
    1490                 1495                 1500             


Gln Ala  Phe Asp Ile Ser Ile  Met Val Leu Ile Cys  Leu Asn Met 
    1505                 1510                 1515             


Val Thr  Met Met Val Glu Lys  Glu Gly Gln Ser Pro  Tyr Met Thr 
    1520                 1525                 1530             


Asp Val  Leu Tyr Trp Ile Asn  Val Val Phe Ile Ile  Leu Phe Thr 
    1535                 1540                 1545             


Gly Glu  Cys Val Leu Lys Leu  Ile Ser Leu Arg Tyr  Tyr Tyr Phe 
    1550                 1555                 1560             


Thr Ile  Gly Trp Asn Ile Phe  Asp Phe Val Val Val  Ile Ile Ser 
    1565                 1570                 1575             


Ile Val  Gly Met Phe Leu Ala  Asp Leu Ile Glu Thr  Tyr Phe Val 
    1580                 1585                 1590             


Ser Pro  Thr Leu Phe Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg 
    1595                 1600                 1605             


Ile Leu  Arg Leu Val Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu 
    1610                 1615                 1620             


Phe Ala  Leu Met Met Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu 
    1625                 1630                 1635             


Leu Leu  Phe Leu Val Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser 
    1640                 1645                 1650             


Asn Phe  Ala Tyr Val Lys Lys  Glu Asp Gly Ile Asn  Asp Met Phe 
    1655                 1660                 1665             


Asn Phe  Glu Thr Phe Gly Asn  Ser Met Ile Cys Leu  Phe Gln Ile 
    1670                 1675                 1680             


Thr Thr  Ser Ala Gly Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn 
    1685                 1690                 1695             


Ser Lys  Pro Pro Asp Cys Asp  Pro Lys Lys Val His  Pro Gly Ser 
    1700                 1705                 1710             


Ser Val  Glu Gly Asp Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr 
    1715                 1720                 1725             


Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu Val Val  Val Asn Met 
    1730                 1735                 1740             


Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu 
    1745                 1750                 1755             


Ser Thr  Glu Pro Leu Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu 
    1760                 1765                 1770             


Val Trp  Glu Lys Phe Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Tyr 
    1775                 1780                 1785             


Asn Lys  Leu Ser Asp Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu 
    1790                 1795                 1800             


Ile Ala  Lys Pro Asn Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro 
    1805                 1810                 1815             


Met Val  Ser Gly Asp Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala 
    1820                 1825                 1830             


Phe Thr  Lys Arg Val Leu Gly  Glu Ser Gly Glu Met  Asp Ser Leu 
    1835                 1840                 1845             


Arg Ser  Gln Met Glu Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys 
    1850                 1855                 1860             


Val Ser  Tyr Glu Pro Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu 
    1865                 1870                 1875             


Asp Val  Ser Ala Thr Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg 
    1880                 1885                 1890             


Leu Arg  Gln Asn Val Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp 
    1895                 1900                 1905             


Gly Asp  Arg Asp Asp Asp Leu  Leu Asn Lys Lys Asp  Met Ala Phe 
    1910                 1915                 1920             


Asp Asn  Val Asn Glu Asn Ser  Ser Pro Glu Lys Thr  Asp Ala Thr 
    1925                 1930                 1935             


Ser Ser  Thr Thr Ser Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Asp Lys  Glu Lys Tyr Glu Gln  Asp Arg Thr Glu Lys  Glu Asp Lys 
    1955                 1960                 1965             


Gly Lys  Asp Ser Lys Glu Ser  Lys Lys Ser Gly Arg  Gly Ser Gly 
    1970                 1975                 1980             


Ala Thr  Asn Phe Ser Leu Leu  Lys Gln Ala Gly Asp  Val Glu Glu 
    1985                 1990                 1995             


Asn Pro  Gly Pro Met Gly Arg  Leu Leu Ala Leu Val  Val Gly Ala 
    2000                 2005                 2010             


Ala Leu  Val Ser Ser Ala Cys  Gly Gly Cys Val Glu  Val Asp Ser 
    2015                 2020                 2025             


Glu Thr  Glu Ala Val Tyr Gly  Met Thr Phe Lys Ile  Leu Cys Ile 
    2030                 2035                 2040             


Ser Cys  Lys Arg Arg Ser Glu  Thr Asn Ala Glu Thr  Phe Thr Glu 
    2045                 2050                 2055             


Trp Thr  Phe Arg Gln Lys Gly  Thr Glu Glu Phe Val  Lys Ile Leu 
    2060                 2065                 2070             


Arg Tyr  Glu Asn Glu Val Leu  Gln Leu Glu Glu Asp  Glu Arg Phe 
    2075                 2080                 2085             


Glu Gly  Arg Val Val Trp Asn  Gly Ser Arg Gly Thr  Lys Asp Leu 
    2090                 2095                 2100             


Gln Asp  Leu Ser Ile Phe Ile  Thr Asn Val Thr Tyr  Asn His Ser 
    2105                 2110                 2115             


Gly Asp  Tyr Glu Cys His Val  Tyr Arg Leu Leu Phe  Phe Glu Asn 
    2120                 2125                 2130             


Tyr Glu  His Asn Thr Ser Val  Val Lys Lys Ile His  Ile Glu Val 
    2135                 2140                 2145             


Val Asp  Lys Ala Asn Arg Asp  Met Ala Ser Ile Val  Ser Glu Ile 
    2150                 2155                 2160             


Met Met  Tyr Val Leu Ile Val  Val Leu Thr Ile Trp  Leu Val Ala 
    2165                 2170                 2175             


Glu Met  Ile Tyr Cys Tyr Lys  Lys Ile Ala Ala Ala  Thr Glu Thr 
    2180                 2185                 2190             


Ala Ala  Gln Glu Asn Ala Ser  Glu Tyr Leu Ala Ile  Thr Ser Glu 
    2195                 2200                 2205             


Ser Lys  Glu Asn Cys Thr Gly  Val Gln Val Ala Glu  Gly Ser Gly 
    2210                 2215                 2220             


Ala Thr  Asn Phe Ser Leu Leu  Lys Gln Ala Gly Asp  Val Glu Glu 
    2225                 2230                 2235             


Asn Pro  Gly Pro Met His Arg  Asp Ala Trp Leu Pro  Arg Pro Ala 
    2240                 2245                 2250             


Phe Ser  Leu Thr Gly Leu Ser  Leu Phe Phe Ser Leu  Val Pro Pro 
    2255                 2260                 2265             


Gly Arg  Ser Met Glu Val Thr  Val Pro Ala Thr Leu  Asn Val Leu 
    2270                 2275                 2280             


Asn Gly  Ser Asp Ala Arg Leu  Pro Cys Thr Phe Asn  Ser Cys Tyr 
    2285                 2290                 2295             


Thr Val  Asn His Lys Gln Phe  Ser Leu Asn Trp Thr  Tyr Gln Glu 
    2300                 2305                 2310             


Cys Asn  Asn Cys Ser Glu Glu  Met Phe Leu Gln Phe  Arg Met Lys 
    2315                 2320                 2325             


Ile Ile  Asn Leu Lys Leu Glu  Arg Phe Gln Asp Arg  Val Glu Phe 
    2330                 2335                 2340             


Ser Gly  Asn Pro Ser Lys Tyr  Asp Val Ser Val Met  Leu Arg Asn 
    2345                 2350                 2355             


Val Gln  Pro Glu Asp Glu Gly  Ile Tyr Asn Cys Tyr  Ile Met Asn 
    2360                 2365                 2370             


Pro Pro  Asp Arg His Arg Gly  His Gly Lys Ile His  Leu Gln Val 
    2375                 2380                 2385             


Leu Met  Glu Glu Pro Pro Glu  Arg Asp Ser Thr Val  Ala Val Ile 
    2390                 2395                 2400             


Val Gly  Ala Ser Val Gly Gly  Phe Leu Ala Val Val  Ile Leu Val 
    2405                 2410                 2415             


Leu Met  Val Val Lys Cys Val  Arg Arg Lys Lys Glu  Gln Lys Leu 
    2420                 2425                 2430             


Ser Thr  Asp Asp Leu Lys Thr  Glu Glu Glu Gly Lys  Thr Asp Gly 
    2435                 2440                 2445             


Glu Gly  Asn Pro Asp Asp Gly  Ala Lys Gly Ser Gly  Ala Thr Asn 
    2450                 2455                 2460             


Phe Ser  Leu Leu Lys Gln Ala  Gly Asp Val Glu Glu  Asn Pro Gly 
    2465                 2470                 2475             


Pro Met  Pro Ala Phe Asn Arg  Leu Phe Pro Leu Ala  Ser Leu Val 
    2480                 2485                 2490             


Leu Ile  Tyr Trp Val Ser Val  Cys Phe Pro Val Cys  Val Glu Val 
    2495                 2500                 2505             


Pro Ser  Glu Thr Glu Ala Val  Gln Gly Asn Pro Met  Lys Leu Arg 
    2510                 2515                 2520             


Cys Ile  Ser Cys Met Lys Arg  Glu Glu Val Glu Ala  Thr Thr Val 
    2525                 2530                 2535             


Val Glu  Trp Phe Tyr Arg Pro  Glu Gly Gly Lys Asp  Phe Leu Ile 
    2540                 2545                 2550             


Tyr Glu  Tyr Arg Asn Gly His  Gln Glu Val Glu Ser  Pro Phe Gln 
    2555                 2560                 2565             


Gly Arg  Leu Gln Trp Asn Gly  Ser Lys Asp Leu Gln  Asp Val Ser 
    2570                 2575                 2580             


Ile Thr  Val Leu Asn Val Thr  Leu Asn Asp Ser Gly  Leu Tyr Thr 
    2585                 2590                 2595             


Cys Asn  Val Ser Arg Glu Phe  Glu Phe Glu Ala His  Arg Pro Phe 
    2600                 2605                 2610             


Val Lys  Thr Thr Arg Leu Ile  Pro Leu Arg Val Thr  Glu Glu Ala 
    2615                 2620                 2625             


Gly Glu  Asp Phe Thr Ser Val  Val Ser Glu Ile Met  Met Tyr Ile 
    2630                 2635                 2640             


Leu Leu  Val Phe Leu Thr Leu  Trp Leu Leu Ile Glu  Met Ile Tyr 
    2645                 2650                 2655             


Cys Tyr  Arg Lys Val Ser Lys  Ala Glu Glu Ala Ala  Gln Glu Asn 
    2660                 2665                 2670             


Ala Ser  Asp Tyr Leu Ala Ile  Pro Ser Glu Asn Lys  Glu Asn Ser 
    2675                 2680                 2685             


Ala Val  Pro Val Glu Glu 
    2690                 


<210>  5
<211>  2730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav1.7(F276V)-beta1-beta2-beta3 viral P2A

<400>  5

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Val Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 
                645                 650                 655     


Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 
            660                 665                 670         


Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 
        675                 680                 685             


Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 
    690                 695                 700                 


Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 
705                 710                 715                 720 


Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 
                725                 730                 735     


Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
            740                 745                 750         


Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 
        755                 760                 765             


Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 
    770                 775                 780                 


Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 
785                 790                 795                 800 


Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 
                805                 810                 815     


Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
            820                 825                 830         


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
        835                 840                 845             


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
    850                 855                 860                 


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
865                 870                 875                 880 


Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 
                885                 890                 895     


Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
            900                 905                 910         


Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
        915                 920                 925             


Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 
    930                 935                 940                 


Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
945                 950                 955                 960 


Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn 
                965                 970                 975     


Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 
            980                 985                 990         


Gln Thr Leu Arg Glu Phe Ile Leu  Lys Ala Phe Ser Lys  Lys Pro Lys 
        995                 1000                 1005             


Ile Ser  Arg Glu Ile Arg Gln  Ala Glu Asp Leu Asn  Thr Lys Lys 
    1010                 1015                 1020             


Glu Asn  Tyr Ile Ser Asn His  Thr Leu Ala Glu Met  Ser Lys Gly 
    1025                 1030                 1035             


His Asn  Phe Leu Lys Glu Lys  Asp Lys Ile Ser Gly  Phe Gly Ser 
    1040                 1045                 1050             


Ser Val  Asp Lys His Leu Met  Glu Asp Ser Asp Gly  Gln Ser Phe 
    1055                 1060                 1065             


Ile His  Asn Pro Ser Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly 
    1070                 1075                 1080             


Glu Ser  Asp Leu Glu Asn Met  Asn Ala Glu Glu Leu  Ser Ser Asp 
    1085                 1090                 1095             


Ser Asp  Ser Glu Tyr Ser Lys  Val Arg Leu Asn Arg  Ser Ser Ser 
    1100                 1105                 1110             


Ser Glu  Cys Ser Thr Val Asp  Asn Pro Leu Pro Gly  Glu Gly Glu 
    1115                 1120                 1125             


Glu Ala  Glu Ala Glu Pro Met  Asn Ser Asp Glu Pro  Glu Ala Cys 
    1130                 1135                 1140             


Phe Thr  Asp Gly Cys Val Arg  Arg Phe Ser Cys Cys  Gln Val Asn 
    1145                 1150                 1155             


Ile Glu  Ser Gly Lys Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr 
    1160                 1165                 1170             


Cys Tyr  Lys Ile Val Glu His  Ser Trp Phe Glu Ser  Phe Ile Val 
    1175                 1180                 1185             


Leu Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1190                 1195                 1200             


Tyr Ile  Glu Arg Lys Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala 
    1205                 1210                 1215             


Asp Lys  Ile Phe Thr Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys 
    1220                 1225                 1230             


Trp Ile  Ala Tyr Gly Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys 
    1235                 1240                 1245             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Leu Val  Thr Leu Val 
    1250                 1255                 1260             


Ala Asn  Thr Leu Gly Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu 
    1265                 1270                 1275             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1280                 1285                 1290             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro 
    1295                 1300                 1305             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1310                 1315                 1320             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu 
    1325                 1330                 1335             


Cys Ile  Asn Thr Thr Asp Gly  Ser Arg Phe Pro Ala  Ser Gln Val 
    1340                 1345                 1350             


Pro Asn  Arg Ser Glu Cys Phe  Ala Leu Met Asn Val  Ser Gln Asn 
    1355                 1360                 1365             


Val Arg  Trp Lys Asn Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu 
    1370                 1375                 1380             


Gly Tyr  Leu Ser Leu Leu Gln  Val Ala Thr Phe Lys  Gly Trp Thr 
    1385                 1390                 1395             


Ile Ile  Met Tyr Ala Ala Val  Asp Ser Val Asn Val  Asp Lys Gln 
    1400                 1405                 1410             


Pro Lys  Tyr Glu Tyr Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Val 
    1415                 1420                 1425             


Phe Ile  Ile Phe Gly Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly 
    1430                 1435                 1440             


Val Ile  Ile Asp Asn Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly 
    1445                 1450                 1455             


Gln Asp  Ile Phe Met Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala 
    1460                 1465                 1470             


Met Lys  Lys Leu Gly Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg 
    1475                 1480                 1485             


Pro Gly  Asn Lys Ile Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn 
    1490                 1495                 1500             


Gln Ala  Phe Asp Ile Ser Ile  Met Val Leu Ile Cys  Leu Asn Met 
    1505                 1510                 1515             


Val Thr  Met Met Val Glu Lys  Glu Gly Gln Ser Gln  His Met Thr 
    1520                 1525                 1530             


Glu Val  Leu Tyr Trp Ile Asn  Val Val Phe Ile Ile  Leu Phe Thr 
    1535                 1540                 1545             


Gly Glu  Cys Val Leu Lys Leu  Ile Ser Leu Arg His  Tyr Tyr Phe 
    1550                 1555                 1560             


Thr Val  Gly Trp Asn Ile Phe  Asp Phe Val Val Val  Ile Ile Ser 
    1565                 1570                 1575             


Ile Val  Gly Met Phe Leu Ala  Asp Leu Ile Glu Thr  Tyr Phe Val 
    1580                 1585                 1590             


Ser Pro  Thr Leu Phe Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg 
    1595                 1600                 1605             


Ile Leu  Arg Leu Val Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu 
    1610                 1615                 1620             


Phe Ala  Leu Met Met Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu 
    1625                 1630                 1635             


Leu Leu  Phe Leu Val Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser 
    1640                 1645                 1650             


Asn Phe  Ala Tyr Val Lys Lys  Glu Asp Gly Ile Asn  Asp Met Phe 
    1655                 1660                 1665             


Asn Phe  Glu Thr Phe Gly Asn  Ser Met Ile Cys Leu  Phe Gln Ile 
    1670                 1675                 1680             


Thr Thr  Ser Ala Gly Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn 
    1685                 1690                 1695             


Ser Lys  Pro Pro Asp Cys Asp  Pro Lys Lys Val His  Pro Gly Ser 
    1700                 1705                 1710             


Ser Val  Glu Gly Asp Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr 
    1715                 1720                 1725             


Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu Val Val  Val Asn Met 
    1730                 1735                 1740             


Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu 
    1745                 1750                 1755             


Ser Thr  Glu Pro Leu Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu 
    1760                 1765                 1770             


Val Trp  Glu Lys Phe Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Phe 
    1775                 1780                 1785             


Ser Lys  Leu Ser Asp Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu 
    1790                 1795                 1800             


Ile Ala  Lys Pro Asn Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro 
    1805                 1810                 1815             


Met Val  Ser Gly Asp Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala 
    1820                 1825                 1830             


Phe Thr  Lys Arg Val Leu Gly  Glu Ser Gly Glu Met  Asp Ser Leu 
    1835                 1840                 1845             


Arg Ser  Gln Met Glu Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys 
    1850                 1855                 1860             


Val Ser  Tyr Glu Pro Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu 
    1865                 1870                 1875             


Asp Val  Ser Ala Thr Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg 
    1880                 1885                 1890             


Leu Arg  Gln Asn Val Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp 
    1895                 1900                 1905             


Gly Asp  Arg Asp Asp Asp Leu  Leu Asn Lys Lys Asp  Met Ala Phe 
    1910                 1915                 1920             


Asp Asn  Val Asn Glu Asn Ser  Ser Pro Glu Lys Thr  Asp Ala Thr 
    1925                 1930                 1935             


Ser Ser  Thr Thr Ser Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Asp Lys  Glu Lys Tyr Glu Gln  Asp Arg Thr Glu Lys  Glu Asp Lys 
    1955                 1960                 1965             


Gly Lys  Asp Ser Lys Glu Ser  Lys Lys Glu Asn Leu  Tyr Phe Gln 
    1970                 1975                 1980             


Gly Asp  Tyr Lys Asp His Asp  Gly Asp Tyr Lys Asp  His Asp Ile 
    1985                 1990                 1995             


Asp Tyr  Lys Asp Asp Asp Asp  Lys His His His His  His His His 
    2000                 2005                 2010             


His His  His Gly Ser Gly Ala  Thr Asn Phe Ser Leu  Leu Lys Gln 
    2015                 2020                 2025             


Ala Gly  Asp Val Glu Glu Asn  Pro Gly Pro Met Gly  Arg Leu Leu 
    2030                 2035                 2040             


Ala Leu  Val Val Gly Ala Ala  Leu Val Ser Ser Ala  Cys Gly Gly 
    2045                 2050                 2055             


Cys Val  Glu Val Asp Ser Glu  Thr Glu Ala Val Tyr  Gly Met Thr 
    2060                 2065                 2070             


Phe Lys  Ile Leu Cys Ile Ser  Cys Lys Arg Arg Ser  Glu Thr Asn 
    2075                 2080                 2085             


Ala Glu  Thr Phe Thr Glu Trp  Thr Phe Arg Gln Lys  Gly Thr Glu 
    2090                 2095                 2100             


Glu Phe  Val Lys Ile Leu Arg  Tyr Glu Asn Glu Val  Leu Gln Leu 
    2105                 2110                 2115             


Glu Glu  Asp Glu Arg Phe Glu  Gly Arg Val Val Trp  Asn Gly Ser 
    2120                 2125                 2130             


Arg Gly  Thr Lys Asp Leu Gln  Asp Leu Ser Ile Phe  Ile Thr Asn 
    2135                 2140                 2145             


Val Thr  Tyr Asn His Ser Gly  Asp Tyr Glu Cys His  Val Tyr Arg 
    2150                 2155                 2160             


Leu Leu  Phe Phe Glu Asn Tyr  Glu His Asn Thr Ser  Val Val Lys 
    2165                 2170                 2175             


Lys Ile  His Ile Glu Val Val  Asp Lys Ala Asn Arg  Asp Met Ala 
    2180                 2185                 2190             


Ser Ile  Val Ser Glu Ile Met  Met Tyr Val Leu Ile  Val Val Leu 
    2195                 2200                 2205             


Thr Ile  Trp Leu Val Ala Glu  Met Ile Tyr Cys Tyr  Lys Lys Ile 
    2210                 2215                 2220             


Ala Ala  Ala Thr Glu Thr Ala  Ala Gln Glu Asn Ala  Ser Glu Tyr 
    2225                 2230                 2235             


Leu Ala  Ile Thr Ser Glu Ser  Lys Glu Asn Cys Thr  Gly Val Gln 
    2240                 2245                 2250             


Val Ala  Glu Gly Ser Gly Ala  Thr Asn Phe Ser Leu  Leu Lys Gln 
    2255                 2260                 2265             


Ala Gly  Asp Val Glu Glu Asn  Pro Gly Pro Met His  Arg Asp Ala 
    2270                 2275                 2280             


Trp Leu  Pro Arg Pro Ala Phe  Ser Leu Thr Gly Leu  Ser Leu Phe 
    2285                 2290                 2295             


Phe Ser  Leu Val Pro Pro Gly  Arg Ser Met Glu Val  Thr Val Pro 
    2300                 2305                 2310             


Ala Thr  Leu Asn Val Leu Asn  Gly Ser Asp Ala Arg  Leu Pro Cys 
    2315                 2320                 2325             


Thr Phe  Asn Ser Cys Tyr Thr  Val Asn His Lys Gln  Phe Ser Leu 
    2330                 2335                 2340             


Asn Trp  Thr Tyr Gln Glu Cys  Asn Asn Cys Ser Glu  Glu Met Phe 
    2345                 2350                 2355             


Leu Gln  Phe Arg Met Lys Ile  Ile Asn Leu Lys Leu  Glu Arg Phe 
    2360                 2365                 2370             


Gln Asp  Arg Val Glu Phe Ser  Gly Asn Pro Ser Lys  Tyr Asp Val 
    2375                 2380                 2385             


Ser Val  Met Leu Arg Asn Val  Gln Pro Glu Asp Glu  Gly Ile Tyr 
    2390                 2395                 2400             


Asn Cys  Tyr Ile Met Asn Pro  Pro Asp Arg His Arg  Gly His Gly 
    2405                 2410                 2415             


Lys Ile  His Leu Gln Val Leu  Met Glu Glu Pro Pro  Glu Arg Asp 
    2420                 2425                 2430             


Ser Thr  Val Ala Val Ile Val  Gly Ala Ser Val Gly  Gly Phe Leu 
    2435                 2440                 2445             


Ala Val  Val Ile Leu Val Leu  Met Val Val Lys Cys  Val Arg Arg 
    2450                 2455                 2460             


Lys Lys  Glu Gln Lys Leu Ser  Thr Asp Asp Leu Lys  Thr Glu Glu 
    2465                 2470                 2475             


Glu Gly  Lys Thr Asp Gly Glu  Gly Asn Pro Asp Asp  Gly Ala Lys 
    2480                 2485                 2490             


Gly Ser  Gly Ala Thr Asn Phe  Ser Leu Leu Lys Gln  Ala Gly Asp 
    2495                 2500                 2505             


Val Glu  Glu Asn Pro Gly Pro  Met Pro Ala Phe Asn  Arg Leu Phe 
    2510                 2515                 2520             


Pro Leu  Ala Ser Leu Val Leu  Ile Tyr Trp Val Ser  Val Cys Phe 
    2525                 2530                 2535             


Pro Val  Cys Val Glu Val Pro  Ser Glu Thr Glu Ala  Val Gln Gly 
    2540                 2545                 2550             


Asn Pro  Met Lys Leu Arg Cys  Ile Ser Cys Met Lys  Arg Glu Glu 
    2555                 2560                 2565             


Val Glu  Ala Thr Thr Val Val  Glu Trp Phe Tyr Arg  Pro Glu Gly 
    2570                 2575                 2580             


Gly Lys  Asp Phe Leu Ile Tyr  Glu Tyr Arg Asn Gly  His Gln Glu 
    2585                 2590                 2595             


Val Glu  Ser Pro Phe Gln Gly  Arg Leu Gln Trp Asn  Gly Ser Lys 
    2600                 2605                 2610             


Asp Leu  Gln Asp Val Ser Ile  Thr Val Leu Asn Val  Thr Leu Asn 
    2615                 2620                 2625             


Asp Ser  Gly Leu Tyr Thr Cys  Asn Val Ser Arg Glu  Phe Glu Phe 
    2630                 2635                 2640             


Glu Ala  His Arg Pro Phe Val  Lys Thr Thr Arg Leu  Ile Pro Leu 
    2645                 2650                 2655             


Arg Val  Thr Glu Glu Ala Gly  Glu Asp Phe Thr Ser  Val Val Ser 
    2660                 2665                 2670             


Glu Ile  Met Met Tyr Ile Leu  Leu Val Phe Leu Thr  Leu Trp Leu 
    2675                 2680                 2685             


Leu Ile  Glu Met Ile Tyr Cys  Tyr Arg Lys Val Ser  Lys Ala Glu 
    2690                 2695                 2700             


Glu Ala  Ala Gln Glu Asn Ala  Ser Asp Tyr Leu Ala  Ile Pro Ser 
    2705                 2710                 2715             


Glu Asn  Lys Glu Asn Ser Ala  Val Pro Val Glu Glu  
    2720                 2725                 2730 


<210>  6
<211>  2730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav1.7(R277Q)-beta1-beta2-beta3 viral P2A

<400>  6

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Gln Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 
                645                 650                 655     


Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 
            660                 665                 670         


Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 
        675                 680                 685             


Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 
    690                 695                 700                 


Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 
705                 710                 715                 720 


Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 
                725                 730                 735     


Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
            740                 745                 750         


Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 
        755                 760                 765             


Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 
    770                 775                 780                 


Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 
785                 790                 795                 800 


Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 
                805                 810                 815     


Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
            820                 825                 830         


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
        835                 840                 845             


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
    850                 855                 860                 


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
865                 870                 875                 880 


Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 
                885                 890                 895     


Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
            900                 905                 910         


Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
        915                 920                 925             


Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 
    930                 935                 940                 


Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
945                 950                 955                 960 


Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn 
                965                 970                 975     


Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 
            980                 985                 990         


Gln Thr Leu Arg Glu Phe Ile Leu  Lys Ala Phe Ser Lys  Lys Pro Lys 
        995                 1000                 1005             


Ile Ser  Arg Glu Ile Arg Gln  Ala Glu Asp Leu Asn  Thr Lys Lys 
    1010                 1015                 1020             


Glu Asn  Tyr Ile Ser Asn His  Thr Leu Ala Glu Met  Ser Lys Gly 
    1025                 1030                 1035             


His Asn  Phe Leu Lys Glu Lys  Asp Lys Ile Ser Gly  Phe Gly Ser 
    1040                 1045                 1050             


Ser Val  Asp Lys His Leu Met  Glu Asp Ser Asp Gly  Gln Ser Phe 
    1055                 1060                 1065             


Ile His  Asn Pro Ser Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly 
    1070                 1075                 1080             


Glu Ser  Asp Leu Glu Asn Met  Asn Ala Glu Glu Leu  Ser Ser Asp 
    1085                 1090                 1095             


Ser Asp  Ser Glu Tyr Ser Lys  Val Arg Leu Asn Arg  Ser Ser Ser 
    1100                 1105                 1110             


Ser Glu  Cys Ser Thr Val Asp  Asn Pro Leu Pro Gly  Glu Gly Glu 
    1115                 1120                 1125             


Glu Ala  Glu Ala Glu Pro Met  Asn Ser Asp Glu Pro  Glu Ala Cys 
    1130                 1135                 1140             


Phe Thr  Asp Gly Cys Val Arg  Arg Phe Ser Cys Cys  Gln Val Asn 
    1145                 1150                 1155             


Ile Glu  Ser Gly Lys Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr 
    1160                 1165                 1170             


Cys Tyr  Lys Ile Val Glu His  Ser Trp Phe Glu Ser  Phe Ile Val 
    1175                 1180                 1185             


Leu Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1190                 1195                 1200             


Tyr Ile  Glu Arg Lys Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala 
    1205                 1210                 1215             


Asp Lys  Ile Phe Thr Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys 
    1220                 1225                 1230             


Trp Ile  Ala Tyr Gly Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys 
    1235                 1240                 1245             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Leu Val  Thr Leu Val 
    1250                 1255                 1260             


Ala Asn  Thr Leu Gly Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu 
    1265                 1270                 1275             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1280                 1285                 1290             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro 
    1295                 1300                 1305             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1310                 1315                 1320             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu 
    1325                 1330                 1335             


Cys Ile  Asn Thr Thr Asp Gly  Ser Arg Phe Pro Ala  Ser Gln Val 
    1340                 1345                 1350             


Pro Asn  Arg Ser Glu Cys Phe  Ala Leu Met Asn Val  Ser Gln Asn 
    1355                 1360                 1365             


Val Arg  Trp Lys Asn Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu 
    1370                 1375                 1380             


Gly Tyr  Leu Ser Leu Leu Gln  Val Ala Thr Phe Lys  Gly Trp Thr 
    1385                 1390                 1395             


Ile Ile  Met Tyr Ala Ala Val  Asp Ser Val Asn Val  Asp Lys Gln 
    1400                 1405                 1410             


Pro Lys  Tyr Glu Tyr Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Val 
    1415                 1420                 1425             


Phe Ile  Ile Phe Gly Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly 
    1430                 1435                 1440             


Val Ile  Ile Asp Asn Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly 
    1445                 1450                 1455             


Gln Asp  Ile Phe Met Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala 
    1460                 1465                 1470             


Met Lys  Lys Leu Gly Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg 
    1475                 1480                 1485             


Pro Gly  Asn Lys Ile Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn 
    1490                 1495                 1500             


Gln Ala  Phe Asp Ile Ser Ile  Met Val Leu Ile Cys  Leu Asn Met 
    1505                 1510                 1515             


Val Thr  Met Met Val Glu Lys  Glu Gly Gln Ser Gln  His Met Thr 
    1520                 1525                 1530             


Glu Val  Leu Tyr Trp Ile Asn  Val Val Phe Ile Ile  Leu Phe Thr 
    1535                 1540                 1545             


Gly Glu  Cys Val Leu Lys Leu  Ile Ser Leu Arg His  Tyr Tyr Phe 
    1550                 1555                 1560             


Thr Val  Gly Trp Asn Ile Phe  Asp Phe Val Val Val  Ile Ile Ser 
    1565                 1570                 1575             


Ile Val  Gly Met Phe Leu Ala  Asp Leu Ile Glu Thr  Tyr Phe Val 
    1580                 1585                 1590             


Ser Pro  Thr Leu Phe Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg 
    1595                 1600                 1605             


Ile Leu  Arg Leu Val Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu 
    1610                 1615                 1620             


Phe Ala  Leu Met Met Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu 
    1625                 1630                 1635             


Leu Leu  Phe Leu Val Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser 
    1640                 1645                 1650             


Asn Phe  Ala Tyr Val Lys Lys  Glu Asp Gly Ile Asn  Asp Met Phe 
    1655                 1660                 1665             


Asn Phe  Glu Thr Phe Gly Asn  Ser Met Ile Cys Leu  Phe Gln Ile 
    1670                 1675                 1680             


Thr Thr  Ser Ala Gly Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn 
    1685                 1690                 1695             


Ser Lys  Pro Pro Asp Cys Asp  Pro Lys Lys Val His  Pro Gly Ser 
    1700                 1705                 1710             


Ser Val  Glu Gly Asp Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr 
    1715                 1720                 1725             


Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu Val Val  Val Asn Met 
    1730                 1735                 1740             


Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu 
    1745                 1750                 1755             


Ser Thr  Glu Pro Leu Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu 
    1760                 1765                 1770             


Val Trp  Glu Lys Phe Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Phe 
    1775                 1780                 1785             


Ser Lys  Leu Ser Asp Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu 
    1790                 1795                 1800             


Ile Ala  Lys Pro Asn Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro 
    1805                 1810                 1815             


Met Val  Ser Gly Asp Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala 
    1820                 1825                 1830             


Phe Thr  Lys Arg Val Leu Gly  Glu Ser Gly Glu Met  Asp Ser Leu 
    1835                 1840                 1845             


Arg Ser  Gln Met Glu Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys 
    1850                 1855                 1860             


Val Ser  Tyr Glu Pro Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu 
    1865                 1870                 1875             


Asp Val  Ser Ala Thr Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg 
    1880                 1885                 1890             


Leu Arg  Gln Asn Val Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp 
    1895                 1900                 1905             


Gly Asp  Arg Asp Asp Asp Leu  Leu Asn Lys Lys Asp  Met Ala Phe 
    1910                 1915                 1920             


Asp Asn  Val Asn Glu Asn Ser  Ser Pro Glu Lys Thr  Asp Ala Thr 
    1925                 1930                 1935             


Ser Ser  Thr Thr Ser Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Asp Lys  Glu Lys Tyr Glu Gln  Asp Arg Thr Glu Lys  Glu Asp Lys 
    1955                 1960                 1965             


Gly Lys  Asp Ser Lys Glu Ser  Lys Lys Glu Asn Leu  Tyr Phe Gln 
    1970                 1975                 1980             


Gly Asp  Tyr Lys Asp His Asp  Gly Asp Tyr Lys Asp  His Asp Ile 
    1985                 1990                 1995             


Asp Tyr  Lys Asp Asp Asp Asp  Lys His His His His  His His His 
    2000                 2005                 2010             


His His  His Gly Ser Gly Ala  Thr Asn Phe Ser Leu  Leu Lys Gln 
    2015                 2020                 2025             


Ala Gly  Asp Val Glu Glu Asn  Pro Gly Pro Met Gly  Arg Leu Leu 
    2030                 2035                 2040             


Ala Leu  Val Val Gly Ala Ala  Leu Val Ser Ser Ala  Cys Gly Gly 
    2045                 2050                 2055             


Cys Val  Glu Val Asp Ser Glu  Thr Glu Ala Val Tyr  Gly Met Thr 
    2060                 2065                 2070             


Phe Lys  Ile Leu Cys Ile Ser  Cys Lys Arg Arg Ser  Glu Thr Asn 
    2075                 2080                 2085             


Ala Glu  Thr Phe Thr Glu Trp  Thr Phe Arg Gln Lys  Gly Thr Glu 
    2090                 2095                 2100             


Glu Phe  Val Lys Ile Leu Arg  Tyr Glu Asn Glu Val  Leu Gln Leu 
    2105                 2110                 2115             


Glu Glu  Asp Glu Arg Phe Glu  Gly Arg Val Val Trp  Asn Gly Ser 
    2120                 2125                 2130             


Arg Gly  Thr Lys Asp Leu Gln  Asp Leu Ser Ile Phe  Ile Thr Asn 
    2135                 2140                 2145             


Val Thr  Tyr Asn His Ser Gly  Asp Tyr Glu Cys His  Val Tyr Arg 
    2150                 2155                 2160             


Leu Leu  Phe Phe Glu Asn Tyr  Glu His Asn Thr Ser  Val Val Lys 
    2165                 2170                 2175             


Lys Ile  His Ile Glu Val Val  Asp Lys Ala Asn Arg  Asp Met Ala 
    2180                 2185                 2190             


Ser Ile  Val Ser Glu Ile Met  Met Tyr Val Leu Ile  Val Val Leu 
    2195                 2200                 2205             


Thr Ile  Trp Leu Val Ala Glu  Met Ile Tyr Cys Tyr  Lys Lys Ile 
    2210                 2215                 2220             


Ala Ala  Ala Thr Glu Thr Ala  Ala Gln Glu Asn Ala  Ser Glu Tyr 
    2225                 2230                 2235             


Leu Ala  Ile Thr Ser Glu Ser  Lys Glu Asn Cys Thr  Gly Val Gln 
    2240                 2245                 2250             


Val Ala  Glu Gly Ser Gly Ala  Thr Asn Phe Ser Leu  Leu Lys Gln 
    2255                 2260                 2265             


Ala Gly  Asp Val Glu Glu Asn  Pro Gly Pro Met His  Arg Asp Ala 
    2270                 2275                 2280             


Trp Leu  Pro Arg Pro Ala Phe  Ser Leu Thr Gly Leu  Ser Leu Phe 
    2285                 2290                 2295             


Phe Ser  Leu Val Pro Pro Gly  Arg Ser Met Glu Val  Thr Val Pro 
    2300                 2305                 2310             


Ala Thr  Leu Asn Val Leu Asn  Gly Ser Asp Ala Arg  Leu Pro Cys 
    2315                 2320                 2325             


Thr Phe  Asn Ser Cys Tyr Thr  Val Asn His Lys Gln  Phe Ser Leu 
    2330                 2335                 2340             


Asn Trp  Thr Tyr Gln Glu Cys  Asn Asn Cys Ser Glu  Glu Met Phe 
    2345                 2350                 2355             


Leu Gln  Phe Arg Met Lys Ile  Ile Asn Leu Lys Leu  Glu Arg Phe 
    2360                 2365                 2370             


Gln Asp  Arg Val Glu Phe Ser  Gly Asn Pro Ser Lys  Tyr Asp Val 
    2375                 2380                 2385             


Ser Val  Met Leu Arg Asn Val  Gln Pro Glu Asp Glu  Gly Ile Tyr 
    2390                 2395                 2400             


Asn Cys  Tyr Ile Met Asn Pro  Pro Asp Arg His Arg  Gly His Gly 
    2405                 2410                 2415             


Lys Ile  His Leu Gln Val Leu  Met Glu Glu Pro Pro  Glu Arg Asp 
    2420                 2425                 2430             


Ser Thr  Val Ala Val Ile Val  Gly Ala Ser Val Gly  Gly Phe Leu 
    2435                 2440                 2445             


Ala Val  Val Ile Leu Val Leu  Met Val Val Lys Cys  Val Arg Arg 
    2450                 2455                 2460             


Lys Lys  Glu Gln Lys Leu Ser  Thr Asp Asp Leu Lys  Thr Glu Glu 
    2465                 2470                 2475             


Glu Gly  Lys Thr Asp Gly Glu  Gly Asn Pro Asp Asp  Gly Ala Lys 
    2480                 2485                 2490             


Gly Ser  Gly Ala Thr Asn Phe  Ser Leu Leu Lys Gln  Ala Gly Asp 
    2495                 2500                 2505             


Val Glu  Glu Asn Pro Gly Pro  Met Pro Ala Phe Asn  Arg Leu Phe 
    2510                 2515                 2520             


Pro Leu  Ala Ser Leu Val Leu  Ile Tyr Trp Val Ser  Val Cys Phe 
    2525                 2530                 2535             


Pro Val  Cys Val Glu Val Pro  Ser Glu Thr Glu Ala  Val Gln Gly 
    2540                 2545                 2550             


Asn Pro  Met Lys Leu Arg Cys  Ile Ser Cys Met Lys  Arg Glu Glu 
    2555                 2560                 2565             


Val Glu  Ala Thr Thr Val Val  Glu Trp Phe Tyr Arg  Pro Glu Gly 
    2570                 2575                 2580             


Gly Lys  Asp Phe Leu Ile Tyr  Glu Tyr Arg Asn Gly  His Gln Glu 
    2585                 2590                 2595             


Val Glu  Ser Pro Phe Gln Gly  Arg Leu Gln Trp Asn  Gly Ser Lys 
    2600                 2605                 2610             


Asp Leu  Gln Asp Val Ser Ile  Thr Val Leu Asn Val  Thr Leu Asn 
    2615                 2620                 2625             


Asp Ser  Gly Leu Tyr Thr Cys  Asn Val Ser Arg Glu  Phe Glu Phe 
    2630                 2635                 2640             


Glu Ala  His Arg Pro Phe Val  Lys Thr Thr Arg Leu  Ile Pro Leu 
    2645                 2650                 2655             


Arg Val  Thr Glu Glu Ala Gly  Glu Asp Phe Thr Ser  Val Val Ser 
    2660                 2665                 2670             


Glu Ile  Met Met Tyr Ile Leu  Leu Val Phe Leu Thr  Leu Trp Leu 
    2675                 2680                 2685             


Leu Ile  Glu Met Ile Tyr Cys  Tyr Arg Lys Val Ser  Lys Ala Glu 
    2690                 2695                 2700             


Glu Ala  Ala Gln Glu Asn Ala  Ser Asp Tyr Leu Ala  Ile Pro Ser 
    2705                 2710                 2715             


Glu Asn  Lys Glu Asn Ser Ala  Val Pro Val Glu Glu  
    2720                 2725                 2730 


<210>  7
<211>  2730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav1.7(E281V)-beta1-beta2-beta3 viral P2A

<400>  7

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Val Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 
                645                 650                 655     


Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 
            660                 665                 670         


Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 
        675                 680                 685             


Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 
    690                 695                 700                 


Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 
705                 710                 715                 720 


Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 
                725                 730                 735     


Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
            740                 745                 750         


Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 
        755                 760                 765             


Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 
    770                 775                 780                 


Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 
785                 790                 795                 800 


Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 
                805                 810                 815     


Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
            820                 825                 830         


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
        835                 840                 845             


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
    850                 855                 860                 


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
865                 870                 875                 880 


Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 
                885                 890                 895     


Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
            900                 905                 910         


Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
        915                 920                 925             


Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 
    930                 935                 940                 


Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
945                 950                 955                 960 


Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn 
                965                 970                 975     


Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 
            980                 985                 990         


Gln Thr Leu Arg Glu Phe Ile Leu  Lys Ala Phe Ser Lys  Lys Pro Lys 
        995                 1000                 1005             


Ile Ser  Arg Glu Ile Arg Gln  Ala Glu Asp Leu Asn  Thr Lys Lys 
    1010                 1015                 1020             


Glu Asn  Tyr Ile Ser Asn His  Thr Leu Ala Glu Met  Ser Lys Gly 
    1025                 1030                 1035             


His Asn  Phe Leu Lys Glu Lys  Asp Lys Ile Ser Gly  Phe Gly Ser 
    1040                 1045                 1050             


Ser Val  Asp Lys His Leu Met  Glu Asp Ser Asp Gly  Gln Ser Phe 
    1055                 1060                 1065             


Ile His  Asn Pro Ser Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly 
    1070                 1075                 1080             


Glu Ser  Asp Leu Glu Asn Met  Asn Ala Glu Glu Leu  Ser Ser Asp 
    1085                 1090                 1095             


Ser Asp  Ser Glu Tyr Ser Lys  Val Arg Leu Asn Arg  Ser Ser Ser 
    1100                 1105                 1110             


Ser Glu  Cys Ser Thr Val Asp  Asn Pro Leu Pro Gly  Glu Gly Glu 
    1115                 1120                 1125             


Glu Ala  Glu Ala Glu Pro Met  Asn Ser Asp Glu Pro  Glu Ala Cys 
    1130                 1135                 1140             


Phe Thr  Asp Gly Cys Val Arg  Arg Phe Ser Cys Cys  Gln Val Asn 
    1145                 1150                 1155             


Ile Glu  Ser Gly Lys Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr 
    1160                 1165                 1170             


Cys Tyr  Lys Ile Val Glu His  Ser Trp Phe Glu Ser  Phe Ile Val 
    1175                 1180                 1185             


Leu Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1190                 1195                 1200             


Tyr Ile  Glu Arg Lys Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala 
    1205                 1210                 1215             


Asp Lys  Ile Phe Thr Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys 
    1220                 1225                 1230             


Trp Ile  Ala Tyr Gly Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys 
    1235                 1240                 1245             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Leu Val  Thr Leu Val 
    1250                 1255                 1260             


Ala Asn  Thr Leu Gly Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu 
    1265                 1270                 1275             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1280                 1285                 1290             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro 
    1295                 1300                 1305             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1310                 1315                 1320             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu 
    1325                 1330                 1335             


Cys Ile  Asn Thr Thr Asp Gly  Ser Arg Phe Pro Ala  Ser Gln Val 
    1340                 1345                 1350             


Pro Asn  Arg Ser Glu Cys Phe  Ala Leu Met Asn Val  Ser Gln Asn 
    1355                 1360                 1365             


Val Arg  Trp Lys Asn Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu 
    1370                 1375                 1380             


Gly Tyr  Leu Ser Leu Leu Gln  Val Ala Thr Phe Lys  Gly Trp Thr 
    1385                 1390                 1395             


Ile Ile  Met Tyr Ala Ala Val  Asp Ser Val Asn Val  Asp Lys Gln 
    1400                 1405                 1410             


Pro Lys  Tyr Glu Tyr Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Val 
    1415                 1420                 1425             


Phe Ile  Ile Phe Gly Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly 
    1430                 1435                 1440             


Val Ile  Ile Asp Asn Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly 
    1445                 1450                 1455             


Gln Asp  Ile Phe Met Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala 
    1460                 1465                 1470             


Met Lys  Lys Leu Gly Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg 
    1475                 1480                 1485             


Pro Gly  Asn Lys Ile Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn 
    1490                 1495                 1500             


Gln Ala  Phe Asp Ile Ser Ile  Met Val Leu Ile Cys  Leu Asn Met 
    1505                 1510                 1515             


Val Thr  Met Met Val Glu Lys  Glu Gly Gln Ser Gln  His Met Thr 
    1520                 1525                 1530             


Glu Val  Leu Tyr Trp Ile Asn  Val Val Phe Ile Ile  Leu Phe Thr 
    1535                 1540                 1545             


Gly Glu  Cys Val Leu Lys Leu  Ile Ser Leu Arg His  Tyr Tyr Phe 
    1550                 1555                 1560             


Thr Val  Gly Trp Asn Ile Phe  Asp Phe Val Val Val  Ile Ile Ser 
    1565                 1570                 1575             


Ile Val  Gly Met Phe Leu Ala  Asp Leu Ile Glu Thr  Tyr Phe Val 
    1580                 1585                 1590             


Ser Pro  Thr Leu Phe Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg 
    1595                 1600                 1605             


Ile Leu  Arg Leu Val Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu 
    1610                 1615                 1620             


Phe Ala  Leu Met Met Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu 
    1625                 1630                 1635             


Leu Leu  Phe Leu Val Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser 
    1640                 1645                 1650             


Asn Phe  Ala Tyr Val Lys Lys  Glu Asp Gly Ile Asn  Asp Met Phe 
    1655                 1660                 1665             


Asn Phe  Glu Thr Phe Gly Asn  Ser Met Ile Cys Leu  Phe Gln Ile 
    1670                 1675                 1680             


Thr Thr  Ser Ala Gly Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn 
    1685                 1690                 1695             


Ser Lys  Pro Pro Asp Cys Asp  Pro Lys Lys Val His  Pro Gly Ser 
    1700                 1705                 1710             


Ser Val  Glu Gly Asp Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr 
    1715                 1720                 1725             


Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu Val Val  Val Asn Met 
    1730                 1735                 1740             


Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu 
    1745                 1750                 1755             


Ser Thr  Glu Pro Leu Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu 
    1760                 1765                 1770             


Val Trp  Glu Lys Phe Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Phe 
    1775                 1780                 1785             


Ser Lys  Leu Ser Asp Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu 
    1790                 1795                 1800             


Ile Ala  Lys Pro Asn Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro 
    1805                 1810                 1815             


Met Val  Ser Gly Asp Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala 
    1820                 1825                 1830             


Phe Thr  Lys Arg Val Leu Gly  Glu Ser Gly Glu Met  Asp Ser Leu 
    1835                 1840                 1845             


Arg Ser  Gln Met Glu Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys 
    1850                 1855                 1860             


Val Ser  Tyr Glu Pro Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu 
    1865                 1870                 1875             


Asp Val  Ser Ala Thr Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg 
    1880                 1885                 1890             


Leu Arg  Gln Asn Val Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp 
    1895                 1900                 1905             


Gly Asp  Arg Asp Asp Asp Leu  Leu Asn Lys Lys Asp  Met Ala Phe 
    1910                 1915                 1920             


Asp Asn  Val Asn Glu Asn Ser  Ser Pro Glu Lys Thr  Asp Ala Thr 
    1925                 1930                 1935             


Ser Ser  Thr Thr Ser Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Asp Lys  Glu Lys Tyr Glu Gln  Asp Arg Thr Glu Lys  Glu Asp Lys 
    1955                 1960                 1965             


Gly Lys  Asp Ser Lys Glu Ser  Lys Lys Glu Asn Leu  Tyr Phe Gln 
    1970                 1975                 1980             


Gly Asp  Tyr Lys Asp His Asp  Gly Asp Tyr Lys Asp  His Asp Ile 
    1985                 1990                 1995             


Asp Tyr  Lys Asp Asp Asp Asp  Lys His His His His  His His His 
    2000                 2005                 2010             


His His  His Gly Ser Gly Ala  Thr Asn Phe Ser Leu  Leu Lys Gln 
    2015                 2020                 2025             


Ala Gly  Asp Val Glu Glu Asn  Pro Gly Pro Met Gly  Arg Leu Leu 
    2030                 2035                 2040             


Ala Leu  Val Val Gly Ala Ala  Leu Val Ser Ser Ala  Cys Gly Gly 
    2045                 2050                 2055             


Cys Val  Glu Val Asp Ser Glu  Thr Glu Ala Val Tyr  Gly Met Thr 
    2060                 2065                 2070             


Phe Lys  Ile Leu Cys Ile Ser  Cys Lys Arg Arg Ser  Glu Thr Asn 
    2075                 2080                 2085             


Ala Glu  Thr Phe Thr Glu Trp  Thr Phe Arg Gln Lys  Gly Thr Glu 
    2090                 2095                 2100             


Glu Phe  Val Lys Ile Leu Arg  Tyr Glu Asn Glu Val  Leu Gln Leu 
    2105                 2110                 2115             


Glu Glu  Asp Glu Arg Phe Glu  Gly Arg Val Val Trp  Asn Gly Ser 
    2120                 2125                 2130             


Arg Gly  Thr Lys Asp Leu Gln  Asp Leu Ser Ile Phe  Ile Thr Asn 
    2135                 2140                 2145             


Val Thr  Tyr Asn His Ser Gly  Asp Tyr Glu Cys His  Val Tyr Arg 
    2150                 2155                 2160             


Leu Leu  Phe Phe Glu Asn Tyr  Glu His Asn Thr Ser  Val Val Lys 
    2165                 2170                 2175             


Lys Ile  His Ile Glu Val Val  Asp Lys Ala Asn Arg  Asp Met Ala 
    2180                 2185                 2190             


Ser Ile  Val Ser Glu Ile Met  Met Tyr Val Leu Ile  Val Val Leu 
    2195                 2200                 2205             


Thr Ile  Trp Leu Val Ala Glu  Met Ile Tyr Cys Tyr  Lys Lys Ile 
    2210                 2215                 2220             


Ala Ala  Ala Thr Glu Thr Ala  Ala Gln Glu Asn Ala  Ser Glu Tyr 
    2225                 2230                 2235             


Leu Ala  Ile Thr Ser Glu Ser  Lys Glu Asn Cys Thr  Gly Val Gln 
    2240                 2245                 2250             


Val Ala  Glu Gly Ser Gly Ala  Thr Asn Phe Ser Leu  Leu Lys Gln 
    2255                 2260                 2265             


Ala Gly  Asp Val Glu Glu Asn  Pro Gly Pro Met His  Arg Asp Ala 
    2270                 2275                 2280             


Trp Leu  Pro Arg Pro Ala Phe  Ser Leu Thr Gly Leu  Ser Leu Phe 
    2285                 2290                 2295             


Phe Ser  Leu Val Pro Pro Gly  Arg Ser Met Glu Val  Thr Val Pro 
    2300                 2305                 2310             


Ala Thr  Leu Asn Val Leu Asn  Gly Ser Asp Ala Arg  Leu Pro Cys 
    2315                 2320                 2325             


Thr Phe  Asn Ser Cys Tyr Thr  Val Asn His Lys Gln  Phe Ser Leu 
    2330                 2335                 2340             


Asn Trp  Thr Tyr Gln Glu Cys  Asn Asn Cys Ser Glu  Glu Met Phe 
    2345                 2350                 2355             


Leu Gln  Phe Arg Met Lys Ile  Ile Asn Leu Lys Leu  Glu Arg Phe 
    2360                 2365                 2370             


Gln Asp  Arg Val Glu Phe Ser  Gly Asn Pro Ser Lys  Tyr Asp Val 
    2375                 2380                 2385             


Ser Val  Met Leu Arg Asn Val  Gln Pro Glu Asp Glu  Gly Ile Tyr 
    2390                 2395                 2400             


Asn Cys  Tyr Ile Met Asn Pro  Pro Asp Arg His Arg  Gly His Gly 
    2405                 2410                 2415             


Lys Ile  His Leu Gln Val Leu  Met Glu Glu Pro Pro  Glu Arg Asp 
    2420                 2425                 2430             


Ser Thr  Val Ala Val Ile Val  Gly Ala Ser Val Gly  Gly Phe Leu 
    2435                 2440                 2445             


Ala Val  Val Ile Leu Val Leu  Met Val Val Lys Cys  Val Arg Arg 
    2450                 2455                 2460             


Lys Lys  Glu Gln Lys Leu Ser  Thr Asp Asp Leu Lys  Thr Glu Glu 
    2465                 2470                 2475             


Glu Gly  Lys Thr Asp Gly Glu  Gly Asn Pro Asp Asp  Gly Ala Lys 
    2480                 2485                 2490             


Gly Ser  Gly Ala Thr Asn Phe  Ser Leu Leu Lys Gln  Ala Gly Asp 
    2495                 2500                 2505             


Val Glu  Glu Asn Pro Gly Pro  Met Pro Ala Phe Asn  Arg Leu Phe 
    2510                 2515                 2520             


Pro Leu  Ala Ser Leu Val Leu  Ile Tyr Trp Val Ser  Val Cys Phe 
    2525                 2530                 2535             


Pro Val  Cys Val Glu Val Pro  Ser Glu Thr Glu Ala  Val Gln Gly 
    2540                 2545                 2550             


Asn Pro  Met Lys Leu Arg Cys  Ile Ser Cys Met Lys  Arg Glu Glu 
    2555                 2560                 2565             


Val Glu  Ala Thr Thr Val Val  Glu Trp Phe Tyr Arg  Pro Glu Gly 
    2570                 2575                 2580             


Gly Lys  Asp Phe Leu Ile Tyr  Glu Tyr Arg Asn Gly  His Gln Glu 
    2585                 2590                 2595             


Val Glu  Ser Pro Phe Gln Gly  Arg Leu Gln Trp Asn  Gly Ser Lys 
    2600                 2605                 2610             


Asp Leu  Gln Asp Val Ser Ile  Thr Val Leu Asn Val  Thr Leu Asn 
    2615                 2620                 2625             


Asp Ser  Gly Leu Tyr Thr Cys  Asn Val Ser Arg Glu  Phe Glu Phe 
    2630                 2635                 2640             


Glu Ala  His Arg Pro Phe Val  Lys Thr Thr Arg Leu  Ile Pro Leu 
    2645                 2650                 2655             


Arg Val  Thr Glu Glu Ala Gly  Glu Asp Phe Thr Ser  Val Val Ser 
    2660                 2665                 2670             


Glu Ile  Met Met Tyr Ile Leu  Leu Val Phe Leu Thr  Leu Trp Leu 
    2675                 2680                 2685             


Leu Ile  Glu Met Ile Tyr Cys  Tyr Arg Lys Val Ser  Lys Ala Glu 
    2690                 2695                 2700             


Glu Ala  Ala Gln Glu Asn Ala  Ser Asp Tyr Leu Ala  Ile Pro Ser 
    2705                 2710                 2715             


Glu Asn  Lys Glu Asn Ser Ala  Val Pro Val Glu Glu  
    2720                 2725                 2730 


<210>  8
<211>  2730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav1.7(V331M)-beta1-beta2-beta3 viral P2A

<400>  8

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Met Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 
                645                 650                 655     


Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 
            660                 665                 670         


Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 
        675                 680                 685             


Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 
    690                 695                 700                 


Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 
705                 710                 715                 720 


Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 
                725                 730                 735     


Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
            740                 745                 750         


Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 
        755                 760                 765             


Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 
    770                 775                 780                 


Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 
785                 790                 795                 800 


Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 
                805                 810                 815     


Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
            820                 825                 830         


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
        835                 840                 845             


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
    850                 855                 860                 


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
865                 870                 875                 880 


Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 
                885                 890                 895     


Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
            900                 905                 910         


Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
        915                 920                 925             


Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 
    930                 935                 940                 


Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
945                 950                 955                 960 


Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn 
                965                 970                 975     


Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 
            980                 985                 990         


Gln Thr Leu Arg Glu Phe Ile Leu  Lys Ala Phe Ser Lys  Lys Pro Lys 
        995                 1000                 1005             


Ile Ser  Arg Glu Ile Arg Gln  Ala Glu Asp Leu Asn  Thr Lys Lys 
    1010                 1015                 1020             


Glu Asn  Tyr Ile Ser Asn His  Thr Leu Ala Glu Met  Ser Lys Gly 
    1025                 1030                 1035             


His Asn  Phe Leu Lys Glu Lys  Asp Lys Ile Ser Gly  Phe Gly Ser 
    1040                 1045                 1050             


Ser Val  Asp Lys His Leu Met  Glu Asp Ser Asp Gly  Gln Ser Phe 
    1055                 1060                 1065             


Ile His  Asn Pro Ser Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly 
    1070                 1075                 1080             


Glu Ser  Asp Leu Glu Asn Met  Asn Ala Glu Glu Leu  Ser Ser Asp 
    1085                 1090                 1095             


Ser Asp  Ser Glu Tyr Ser Lys  Val Arg Leu Asn Arg  Ser Ser Ser 
    1100                 1105                 1110             


Ser Glu  Cys Ser Thr Val Asp  Asn Pro Leu Pro Gly  Glu Gly Glu 
    1115                 1120                 1125             


Glu Ala  Glu Ala Glu Pro Met  Asn Ser Asp Glu Pro  Glu Ala Cys 
    1130                 1135                 1140             


Phe Thr  Asp Gly Cys Val Arg  Arg Phe Ser Cys Cys  Gln Val Asn 
    1145                 1150                 1155             


Ile Glu  Ser Gly Lys Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr 
    1160                 1165                 1170             


Cys Tyr  Lys Ile Val Glu His  Ser Trp Phe Glu Ser  Phe Ile Val 
    1175                 1180                 1185             


Leu Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1190                 1195                 1200             


Tyr Ile  Glu Arg Lys Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala 
    1205                 1210                 1215             


Asp Lys  Ile Phe Thr Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys 
    1220                 1225                 1230             


Trp Ile  Ala Tyr Gly Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys 
    1235                 1240                 1245             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Leu Val  Thr Leu Val 
    1250                 1255                 1260             


Ala Asn  Thr Leu Gly Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu 
    1265                 1270                 1275             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1280                 1285                 1290             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro 
    1295                 1300                 1305             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1310                 1315                 1320             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu 
    1325                 1330                 1335             


Cys Ile  Asn Thr Thr Asp Gly  Ser Arg Phe Pro Ala  Ser Gln Val 
    1340                 1345                 1350             


Pro Asn  Arg Ser Glu Cys Phe  Ala Leu Met Asn Val  Ser Gln Asn 
    1355                 1360                 1365             


Val Arg  Trp Lys Asn Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu 
    1370                 1375                 1380             


Gly Tyr  Leu Ser Leu Leu Gln  Val Ala Thr Phe Lys  Gly Trp Thr 
    1385                 1390                 1395             


Ile Ile  Met Tyr Ala Ala Val  Asp Ser Val Asn Val  Asp Lys Gln 
    1400                 1405                 1410             


Pro Lys  Tyr Glu Tyr Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Val 
    1415                 1420                 1425             


Phe Ile  Ile Phe Gly Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly 
    1430                 1435                 1440             


Val Ile  Ile Asp Asn Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly 
    1445                 1450                 1455             


Gln Asp  Ile Phe Met Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala 
    1460                 1465                 1470             


Met Lys  Lys Leu Gly Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg 
    1475                 1480                 1485             


Pro Gly  Asn Lys Ile Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn 
    1490                 1495                 1500             


Gln Ala  Phe Asp Ile Ser Ile  Met Val Leu Ile Cys  Leu Asn Met 
    1505                 1510                 1515             


Val Thr  Met Met Val Glu Lys  Glu Gly Gln Ser Gln  His Met Thr 
    1520                 1525                 1530             


Glu Val  Leu Tyr Trp Ile Asn  Val Val Phe Ile Ile  Leu Phe Thr 
    1535                 1540                 1545             


Gly Glu  Cys Val Leu Lys Leu  Ile Ser Leu Arg His  Tyr Tyr Phe 
    1550                 1555                 1560             


Thr Val  Gly Trp Asn Ile Phe  Asp Phe Val Val Val  Ile Ile Ser 
    1565                 1570                 1575             


Ile Val  Gly Met Phe Leu Ala  Asp Leu Ile Glu Thr  Tyr Phe Val 
    1580                 1585                 1590             


Ser Pro  Thr Leu Phe Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg 
    1595                 1600                 1605             


Ile Leu  Arg Leu Val Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu 
    1610                 1615                 1620             


Phe Ala  Leu Met Met Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu 
    1625                 1630                 1635             


Leu Leu  Phe Leu Val Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser 
    1640                 1645                 1650             


Asn Phe  Ala Tyr Val Lys Lys  Glu Asp Gly Ile Asn  Asp Met Phe 
    1655                 1660                 1665             


Asn Phe  Glu Thr Phe Gly Asn  Ser Met Ile Cys Leu  Phe Gln Ile 
    1670                 1675                 1680             


Thr Thr  Ser Ala Gly Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn 
    1685                 1690                 1695             


Ser Lys  Pro Pro Asp Cys Asp  Pro Lys Lys Val His  Pro Gly Ser 
    1700                 1705                 1710             


Ser Val  Glu Gly Asp Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr 
    1715                 1720                 1725             


Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu Val Val  Val Asn Met 
    1730                 1735                 1740             


Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu 
    1745                 1750                 1755             


Ser Thr  Glu Pro Leu Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu 
    1760                 1765                 1770             


Val Trp  Glu Lys Phe Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Phe 
    1775                 1780                 1785             


Ser Lys  Leu Ser Asp Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu 
    1790                 1795                 1800             


Ile Ala  Lys Pro Asn Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro 
    1805                 1810                 1815             


Met Val  Ser Gly Asp Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala 
    1820                 1825                 1830             


Phe Thr  Lys Arg Val Leu Gly  Glu Ser Gly Glu Met  Asp Ser Leu 
    1835                 1840                 1845             


Arg Ser  Gln Met Glu Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys 
    1850                 1855                 1860             


Val Ser  Tyr Glu Pro Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu 
    1865                 1870                 1875             


Asp Val  Ser Ala Thr Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg 
    1880                 1885                 1890             


Leu Arg  Gln Asn Val Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp 
    1895                 1900                 1905             


Gly Asp  Arg Asp Asp Asp Leu  Leu Asn Lys Lys Asp  Met Ala Phe 
    1910                 1915                 1920             


Asp Asn  Val Asn Glu Asn Ser  Ser Pro Glu Lys Thr  Asp Ala Thr 
    1925                 1930                 1935             


Ser Ser  Thr Thr Ser Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Asp Lys  Glu Lys Tyr Glu Gln  Asp Arg Thr Glu Lys  Glu Asp Lys 
    1955                 1960                 1965             


Gly Lys  Asp Ser Lys Glu Ser  Lys Lys Glu Asn Leu  Tyr Phe Gln 
    1970                 1975                 1980             


Gly Asp  Tyr Lys Asp His Asp  Gly Asp Tyr Lys Asp  His Asp Ile 
    1985                 1990                 1995             


Asp Tyr  Lys Asp Asp Asp Asp  Lys His His His His  His His His 
    2000                 2005                 2010             


His His  His Gly Ser Gly Ala  Thr Asn Phe Ser Leu  Leu Lys Gln 
    2015                 2020                 2025             


Ala Gly  Asp Val Glu Glu Asn  Pro Gly Pro Met Gly  Arg Leu Leu 
    2030                 2035                 2040             


Ala Leu  Val Val Gly Ala Ala  Leu Val Ser Ser Ala  Cys Gly Gly 
    2045                 2050                 2055             


Cys Val  Glu Val Asp Ser Glu  Thr Glu Ala Val Tyr  Gly Met Thr 
    2060                 2065                 2070             


Phe Lys  Ile Leu Cys Ile Ser  Cys Lys Arg Arg Ser  Glu Thr Asn 
    2075                 2080                 2085             


Ala Glu  Thr Phe Thr Glu Trp  Thr Phe Arg Gln Lys  Gly Thr Glu 
    2090                 2095                 2100             


Glu Phe  Val Lys Ile Leu Arg  Tyr Glu Asn Glu Val  Leu Gln Leu 
    2105                 2110                 2115             


Glu Glu  Asp Glu Arg Phe Glu  Gly Arg Val Val Trp  Asn Gly Ser 
    2120                 2125                 2130             


Arg Gly  Thr Lys Asp Leu Gln  Asp Leu Ser Ile Phe  Ile Thr Asn 
    2135                 2140                 2145             


Val Thr  Tyr Asn His Ser Gly  Asp Tyr Glu Cys His  Val Tyr Arg 
    2150                 2155                 2160             


Leu Leu  Phe Phe Glu Asn Tyr  Glu His Asn Thr Ser  Val Val Lys 
    2165                 2170                 2175             


Lys Ile  His Ile Glu Val Val  Asp Lys Ala Asn Arg  Asp Met Ala 
    2180                 2185                 2190             


Ser Ile  Val Ser Glu Ile Met  Met Tyr Val Leu Ile  Val Val Leu 
    2195                 2200                 2205             


Thr Ile  Trp Leu Val Ala Glu  Met Ile Tyr Cys Tyr  Lys Lys Ile 
    2210                 2215                 2220             


Ala Ala  Ala Thr Glu Thr Ala  Ala Gln Glu Asn Ala  Ser Glu Tyr 
    2225                 2230                 2235             


Leu Ala  Ile Thr Ser Glu Ser  Lys Glu Asn Cys Thr  Gly Val Gln 
    2240                 2245                 2250             


Val Ala  Glu Gly Ser Gly Ala  Thr Asn Phe Ser Leu  Leu Lys Gln 
    2255                 2260                 2265             


Ala Gly  Asp Val Glu Glu Asn  Pro Gly Pro Met His  Arg Asp Ala 
    2270                 2275                 2280             


Trp Leu  Pro Arg Pro Ala Phe  Ser Leu Thr Gly Leu  Ser Leu Phe 
    2285                 2290                 2295             


Phe Ser  Leu Val Pro Pro Gly  Arg Ser Met Glu Val  Thr Val Pro 
    2300                 2305                 2310             


Ala Thr  Leu Asn Val Leu Asn  Gly Ser Asp Ala Arg  Leu Pro Cys 
    2315                 2320                 2325             


Thr Phe  Asn Ser Cys Tyr Thr  Val Asn His Lys Gln  Phe Ser Leu 
    2330                 2335                 2340             


Asn Trp  Thr Tyr Gln Glu Cys  Asn Asn Cys Ser Glu  Glu Met Phe 
    2345                 2350                 2355             


Leu Gln  Phe Arg Met Lys Ile  Ile Asn Leu Lys Leu  Glu Arg Phe 
    2360                 2365                 2370             


Gln Asp  Arg Val Glu Phe Ser  Gly Asn Pro Ser Lys  Tyr Asp Val 
    2375                 2380                 2385             


Ser Val  Met Leu Arg Asn Val  Gln Pro Glu Asp Glu  Gly Ile Tyr 
    2390                 2395                 2400             


Asn Cys  Tyr Ile Met Asn Pro  Pro Asp Arg His Arg  Gly His Gly 
    2405                 2410                 2415             


Lys Ile  His Leu Gln Val Leu  Met Glu Glu Pro Pro  Glu Arg Asp 
    2420                 2425                 2430             


Ser Thr  Val Ala Val Ile Val  Gly Ala Ser Val Gly  Gly Phe Leu 
    2435                 2440                 2445             


Ala Val  Val Ile Leu Val Leu  Met Val Val Lys Cys  Val Arg Arg 
    2450                 2455                 2460             


Lys Lys  Glu Gln Lys Leu Ser  Thr Asp Asp Leu Lys  Thr Glu Glu 
    2465                 2470                 2475             


Glu Gly  Lys Thr Asp Gly Glu  Gly Asn Pro Asp Asp  Gly Ala Lys 
    2480                 2485                 2490             


Gly Ser  Gly Ala Thr Asn Phe  Ser Leu Leu Lys Gln  Ala Gly Asp 
    2495                 2500                 2505             


Val Glu  Glu Asn Pro Gly Pro  Met Pro Ala Phe Asn  Arg Leu Phe 
    2510                 2515                 2520             


Pro Leu  Ala Ser Leu Val Leu  Ile Tyr Trp Val Ser  Val Cys Phe 
    2525                 2530                 2535             


Pro Val  Cys Val Glu Val Pro  Ser Glu Thr Glu Ala  Val Gln Gly 
    2540                 2545                 2550             


Asn Pro  Met Lys Leu Arg Cys  Ile Ser Cys Met Lys  Arg Glu Glu 
    2555                 2560                 2565             


Val Glu  Ala Thr Thr Val Val  Glu Trp Phe Tyr Arg  Pro Glu Gly 
    2570                 2575                 2580             


Gly Lys  Asp Phe Leu Ile Tyr  Glu Tyr Arg Asn Gly  His Gln Glu 
    2585                 2590                 2595             


Val Glu  Ser Pro Phe Gln Gly  Arg Leu Gln Trp Asn  Gly Ser Lys 
    2600                 2605                 2610             


Asp Leu  Gln Asp Val Ser Ile  Thr Val Leu Asn Val  Thr Leu Asn 
    2615                 2620                 2625             


Asp Ser  Gly Leu Tyr Thr Cys  Asn Val Ser Arg Glu  Phe Glu Phe 
    2630                 2635                 2640             


Glu Ala  His Arg Pro Phe Val  Lys Thr Thr Arg Leu  Ile Pro Leu 
    2645                 2650                 2655             


Arg Val  Thr Glu Glu Ala Gly  Glu Asp Phe Thr Ser  Val Val Ser 
    2660                 2665                 2670             


Glu Ile  Met Met Tyr Ile Leu  Leu Val Phe Leu Thr  Leu Trp Leu 
    2675                 2680                 2685             


Leu Ile  Glu Met Ile Tyr Cys  Tyr Arg Lys Val Ser  Lys Ala Glu 
    2690                 2695                 2700             


Glu Ala  Ala Gln Glu Asn Ala  Ser Asp Tyr Leu Ala  Ile Pro Ser 
    2705                 2710                 2715             


Glu Asn  Lys Glu Asn Ser Ala  Val Pro Val Glu Glu  
    2720                 2725                 2730 


<210>  9
<211>  3055
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav1.7(N146S,V194I,F276V,R277Q,E281V,V331M,E504D,D507E,S508N,N5
       33S)-beta1-beta2-beta3 viral P2A

<400>  9

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Ile Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Val Gln Asn Ser Leu Val Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Met Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Met Ala Met Leu Pro Pro Pro Gly 
        355                 360                 365             


Pro Gln Ser Phe Val His Phe Thr Lys Gln Ser Leu Ala Leu Ile Glu 
    370                 375                 380                 


Gln Arg Ile Ala Glu Arg Lys Ser Lys Glu Pro Lys Glu Glu Lys Lys 
385                 390                 395                 400 


Asp Asp Asp Glu Glu Ala Pro Lys Pro Ser Ser Asp Leu Glu Ala Gly 
                405                 410                 415     


Lys Gln Leu Pro Phe Ile Tyr Gly Asp Ile Pro Pro Gly Met Val Ser 
            420                 425                 430         


Glu Pro Leu Glu Asp Leu Asp Pro Tyr Tyr Ala Asp Lys Lys Thr Phe 
        435                 440                 445             


Ile Val Leu Asn Lys Gly Lys Thr Ile Phe Arg Phe Asn Ala Thr Pro 
    450                 455                 460                 


Ala Leu Tyr Met Leu Ser Pro Phe Ser Pro Leu Arg Arg Ile Ser Ile 
465                 470                 475                 480 


Lys Ile Leu Val His Ser Leu Phe Ser Met Leu Ile Met Cys Thr Ile 
                485                 490                 495     


Leu Thr Asn Cys Ile Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr 
            500                 505                 510         


Lys Asn Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu 
        515                 520                 525             


Val Lys Ile Leu Ala Arg Gly Phe Cys Val Gly Glu Phe Thr Phe Leu 
    530                 535                 540                 


Arg Asp Pro Trp Asn Trp Leu Asp Phe Ile Val Ile Val Phe Ala Tyr 
545                 550                 555                 560 


Leu Thr Glu Phe Val Asn Leu Gly Asn Val Ser Ala Leu Arg Thr Phe 
                565                 570                 575     


Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys 
            580                 585                 590         


Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val 
        595                 600                 605             


Met Ile Leu Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu 
    610                 615                 620                 


Gln Leu Phe Met Gly Asn Leu Lys His Lys Cys Val Gln Asn Ser Leu 
625                 630                 635                 640 


Val Asn Asn Glu Thr Leu Glu Ser Ile Met Asn Thr Leu Glu Ser Glu 
                645                 650                 655     


Glu Asp Phe Arg Lys Tyr Phe Tyr Tyr Leu Glu Gly Ser Lys Asp Ala 
            660                 665                 670         


Leu Leu Cys Gly Phe Ser Thr Asp Ser Gly Gln Cys Pro Glu Gly Tyr 
        675                 680                 685             


Thr Cys Met Lys Ile Gly Arg Asn Pro Asp Tyr Gly Tyr Thr Ser Phe 
    690                 695                 700                 


Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe Arg Leu Met Thr Gln 
705                 710                 715                 720 


Asp Tyr Trp Glu Asn Leu Tyr Gln Gln Thr Leu Arg Ala Ala Gly Lys 
                725                 730                 735     


Thr Tyr Met Ile Phe Phe Val Val Val Ile Phe Leu Gly Ser Phe Tyr 
            740                 745                 750         


Leu Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln 
        755                 760                 765             


Asn Gln Ala Asn Ile Glu Glu Ala Lys Gln Lys Glu Leu Glu Phe Gln 
    770                 775                 780                 


Gln Met Leu Asp Arg Leu Lys Lys Glu Gln Glu Glu Ala Glu Ala Ile 
785                 790                 795                 800 


Ala Ala Ala Ala Ala Glu Tyr Thr Ser Ile Arg Arg Ser Arg Ile Met 
                805                 810                 815     


Gly Leu Ser Glu Ser Ser Ser Glu Thr Ser Lys Leu Ser Ser Lys Ser 
            820                 825                 830         


Ala Lys Glu Arg Arg Asn Arg Arg Lys Lys Lys Asn Gln Lys Lys Leu 
        835                 840                 845             


Ser Ser Gly Glu Glu Lys Gly Asp Ala Glu Lys Leu Ser Lys Ser Asp 
    850                 855                 860                 


Ser Glu Glu Asn Ile Arg Arg Lys Ser Phe His Leu Gly Val Glu Gly 
865                 870                 875                 880 


His Arg Arg Ala His Glu Lys Arg Leu Ser Thr Pro Ser Gln Ser Pro 
                885                 890                 895     


Leu Ser Ile Arg Gly Ser Leu Phe Ser Ala Arg Arg Ser Ser Arg Thr 
            900                 905                 910         


Ser Leu Phe Ser Phe Lys Gly Arg Gly Arg Asp Ile Gly Ser Glu Thr 
        915                 920                 925             


Glu Phe Ala Asp Asp Glu His Ser Ile Phe Gly Asp Asn Glu Ser Arg 
    930                 935                 940                 


Arg Gly Ser Leu Phe Val Pro His Arg Pro Gln Glu Arg Arg Ser Ser 
945                 950                 955                 960 


Asn Ile Ser Gln Ala Ser Arg Ser Pro Pro Met Leu Pro Val Asn Gly 
                965                 970                 975     


Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu Val Asp 
            980                 985                 990         


Gly Arg Ser Ala Leu Met Leu Pro  Asn Gly Gln Leu Leu  Pro Glu Gly 
        995                 1000                 1005             


Thr Thr  Asn Gln Ile His Lys  Lys Arg Arg Cys Ser  Ser Tyr Leu 
    1010                 1015                 1020             


Leu Ser  Glu Asp Met Leu Asn  Asp Pro Asn Leu Arg  Gln Arg Ala 
    1025                 1030                 1035             


Met Ser  Arg Ala Ser Ile Leu  Thr Asn Thr Val Glu  Glu Leu Glu 
    1040                 1045                 1050             


Glu Ser  Arg Gln Lys Cys Pro  Pro Trp Trp Tyr Arg  Phe Ala His 
    1055                 1060                 1065             


Lys Phe  Leu Ile Trp Asn Cys  Ser Pro Tyr Trp Ile  Lys Phe Lys 
    1070                 1075                 1080             


Lys Cys  Ile Tyr Phe Ile Val  Met Asp Pro Phe Val  Asp Leu Ala 
    1085                 1090                 1095             


Ile Thr  Ile Cys Ile Val Leu  Asn Thr Leu Phe Met  Ala Met Glu 
    1100                 1105                 1110             


His His  Pro Met Thr Glu Glu  Phe Lys Asn Val Leu  Ala Ile Gly 
    1115                 1120                 1125             


Asn Leu  Val Phe Thr Gly Ile  Phe Ala Ala Glu Met  Val Leu Lys 
    1130                 1135                 1140             


Leu Ile  Ala Met Asp Pro Tyr  Glu Tyr Phe Gln Val  Gly Trp Asn 
    1145                 1150                 1155             


Ile Phe  Asp Ser Leu Ile Val  Thr Leu Ser Leu Val  Glu Leu Phe 
    1160                 1165                 1170             


Leu Ala  Asp Val Glu Gly Leu  Ser Val Leu Arg Ser  Phe Arg Leu 
    1175                 1180                 1185             


Leu Arg  Val Phe Lys Leu Ala  Lys Ser Trp Pro Thr  Leu Asn Met 
    1190                 1195                 1200             


Leu Ile  Lys Ile Ile Gly Asn  Ser Val Gly Ala Leu  Gly Asn Leu 
    1205                 1210                 1215             


Thr Leu  Val Leu Ala Ile Ile  Val Phe Ile Phe Ala  Val Val Gly 
    1220                 1225                 1230             


Met Gln  Leu Phe Gly Lys Ser  Tyr Lys Glu Cys Val  Cys Lys Ile 
    1235                 1240                 1245             


Asn Asp  Asp Cys Thr Leu Pro  Arg Trp His Met Asn  Asp Phe Phe 
    1250                 1255                 1260             


His Ser  Phe Leu Ile Val Phe  Arg Val Leu Cys Gly  Glu Trp Ile 
    1265                 1270                 1275             


Glu Thr  Met Trp Asp Cys Met  Glu Val Ala Gly Gln  Ala Met Cys 
    1280                 1285                 1290             


Leu Ile  Val Tyr Met Met Val  Met Val Ile Gly Asn  Leu Val Val 
    1295                 1300                 1305             


Leu Asn  Leu Phe Leu Ala Leu  Leu Leu Ser Ser Phe  Ser Ser Asp 
    1310                 1315                 1320             


Asn Leu  Thr Ala Ile Glu Glu  Asp Pro Asp Ala Asn  Asn Leu Gln 
    1325                 1330                 1335             


Ile Ala  Val Thr Arg Ile Lys  Lys Gly Ile Asn Tyr  Val Lys Gln 
    1340                 1345                 1350             


Thr Leu  Arg Glu Phe Ile Leu  Lys Ala Phe Ser Lys  Lys Pro Lys 
    1355                 1360                 1365             


Ile Ser  Arg Glu Ile Arg Gln  Ala Glu Asp Leu Asn  Thr Lys Lys 
    1370                 1375                 1380             


Glu Asn  Tyr Ile Ser Asn His  Thr Leu Ala Glu Met  Ser Lys Gly 
    1385                 1390                 1395             


His Asn  Phe Leu Lys Glu Lys  Asp Lys Ile Ser Gly  Phe Gly Ser 
    1400                 1405                 1410             


Ser Val  Asp Lys His Leu Met  Glu Asp Ser Asp Gly  Gln Ser Phe 
    1415                 1420                 1425             


Ile His  Asn Pro Ser Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly 
    1430                 1435                 1440             


Glu Ser  Asp Leu Glu Asn Met  Asn Ala Glu Glu Leu  Ser Ser Asp 
    1445                 1450                 1455             


Ser Asp  Ser Glu Tyr Ser Lys  Val Arg Leu Asn Arg  Ser Ser Ser 
    1460                 1465                 1470             


Ser Glu  Cys Ser Thr Val Asp  Asn Pro Leu Pro Gly  Glu Gly Glu 
    1475                 1480                 1485             


Glu Ala  Glu Ala Glu Pro Met  Asn Ser Asp Glu Pro  Glu Ala Cys 
    1490                 1495                 1500             


Phe Thr  Asp Gly Cys Val Arg  Arg Phe Ser Cys Cys  Gln Val Asn 
    1505                 1510                 1515             


Ile Glu  Ser Gly Lys Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr 
    1520                 1525                 1530             


Cys Tyr  Lys Ile Val Glu His  Ser Trp Phe Glu Ser  Phe Ile Val 
    1535                 1540                 1545             


Leu Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1550                 1555                 1560             


Tyr Ile  Glu Arg Lys Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala 
    1565                 1570                 1575             


Asp Lys  Ile Phe Thr Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys 
    1580                 1585                 1590             


Trp Ile  Ala Tyr Gly Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys 
    1595                 1600                 1605             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Leu Val  Thr Leu Val 
    1610                 1615                 1620             


Ala Asn  Thr Leu Gly Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu 
    1625                 1630                 1635             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1640                 1645                 1650             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro 
    1655                 1660                 1665             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1670                 1675                 1680             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu 
    1685                 1690                 1695             


Cys Ile  Asn Thr Thr Asp Gly  Ser Arg Phe Pro Ala  Ser Gln Val 
    1700                 1705                 1710             


Pro Asn  Arg Ser Glu Cys Phe  Ala Leu Met Asn Val  Ser Gln Asn 
    1715                 1720                 1725             


Val Arg  Trp Lys Asn Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu 
    1730                 1735                 1740             


Gly Tyr  Leu Ser Leu Leu Gln  Val Ala Thr Phe Lys  Gly Trp Thr 
    1745                 1750                 1755             


Ile Ile  Met Tyr Ala Ala Val  Asp Ser Val Asn Val  Asp Lys Gln 
    1760                 1765                 1770             


Pro Lys  Tyr Glu Tyr Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Val 
    1775                 1780                 1785             


Phe Ile  Ile Phe Gly Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly 
    1790                 1795                 1800             


Val Ile  Ile Asp Asn Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly 
    1805                 1810                 1815             


Gln Asp  Ile Phe Met Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala 
    1820                 1825                 1830             


Met Lys  Lys Leu Gly Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg 
    1835                 1840                 1845             


Pro Gly  Asn Lys Ile Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn 
    1850                 1855                 1860             


Gln Ala  Phe Asp Ile Ser Ile  Met Val Leu Ile Cys  Leu Asn Met 
    1865                 1870                 1875             


Val Thr  Met Met Val Glu Lys  Glu Gly Gln Ser Gln  His Met Thr 
    1880                 1885                 1890             


Glu Val  Leu Tyr Trp Ile Asn  Val Val Phe Ile Ile  Leu Phe Thr 
    1895                 1900                 1905             


Gly Glu  Cys Val Leu Lys Leu  Ile Ser Leu Arg His  Tyr Tyr Phe 
    1910                 1915                 1920             


Thr Val  Gly Trp Asn Ile Phe  Asp Phe Val Val Val  Ile Ile Ser 
    1925                 1930                 1935             


Ile Val  Gly Met Phe Leu Ala  Asp Leu Ile Glu Thr  Tyr Phe Val 
    1940                 1945                 1950             


Ser Pro  Thr Leu Phe Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg 
    1955                 1960                 1965             


Ile Leu  Arg Leu Val Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu 
    1970                 1975                 1980             


Phe Ala  Leu Met Met Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu 
    1985                 1990                 1995             


Leu Leu  Phe Leu Val Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser 
    2000                 2005                 2010             


Asn Phe  Ala Tyr Val Lys Lys  Glu Asp Gly Ile Asn  Asp Met Phe 
    2015                 2020                 2025             


Asn Phe  Glu Thr Phe Gly Asn  Ser Met Ile Cys Leu  Phe Gln Ile 
    2030                 2035                 2040             


Thr Thr  Ser Ala Gly Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn 
    2045                 2050                 2055             


Ser Lys  Pro Pro Asp Cys Asp  Pro Lys Lys Val His  Pro Gly Ser 
    2060                 2065                 2070             


Ser Val  Glu Gly Asp Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr 
    2075                 2080                 2085             


Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu Val Val  Val Asn Met 
    2090                 2095                 2100             


Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu 
    2105                 2110                 2115             


Ser Thr  Glu Pro Leu Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu 
    2120                 2125                 2130             


Val Trp  Glu Lys Phe Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Phe 
    2135                 2140                 2145             


Ser Lys  Leu Ser Asp Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu 
    2150                 2155                 2160             


Ile Ala  Lys Pro Asn Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro 
    2165                 2170                 2175             


Met Val  Ser Gly Asp Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala 
    2180                 2185                 2190             


Phe Thr  Lys Arg Val Leu Gly  Glu Ser Gly Glu Met  Asp Ser Leu 
    2195                 2200                 2205             


Arg Ser  Gln Met Glu Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys 
    2210                 2215                 2220             


Val Ser  Tyr Glu Pro Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu 
    2225                 2230                 2235             


Asp Val  Ser Ala Thr Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg 
    2240                 2245                 2250             


Leu Arg  Gln Asn Val Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp 
    2255                 2260                 2265             


Gly Asp  Arg Asp Asp Asp Leu  Leu Asn Lys Lys Asp  Met Ala Phe 
    2270                 2275                 2280             


Asp Asn  Val Asn Glu Asn Ser  Ser Pro Glu Lys Thr  Asp Ala Thr 
    2285                 2290                 2295             


Ser Ser  Thr Thr Ser Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    2300                 2305                 2310             


Asp Lys  Glu Lys Tyr Glu Gln  Asp Arg Thr Glu Lys  Glu Asp Lys 
    2315                 2320                 2325             


Gly Lys  Asp Ser Lys Glu Ser  Lys Lys Ser Gly Arg  Gly Ser Gly 
    2330                 2335                 2340             


Ala Thr  Asn Phe Ser Leu Leu  Lys Gln Ala Gly Asp  Val Glu Glu 
    2345                 2350                 2355             


Asn Pro  Gly Pro Met Gly Arg  Leu Leu Ala Leu Val  Val Gly Ala 
    2360                 2365                 2370             


Ala Leu  Val Ser Ser Ala Cys  Gly Gly Cys Val Glu  Val Asp Ser 
    2375                 2380                 2385             


Glu Thr  Glu Ala Val Tyr Gly  Met Thr Phe Lys Ile  Leu Cys Ile 
    2390                 2395                 2400             


Ser Cys  Lys Arg Arg Ser Glu  Thr Asn Ala Glu Thr  Phe Thr Glu 
    2405                 2410                 2415             


Trp Thr  Phe Arg Gln Lys Gly  Thr Glu Glu Phe Val  Lys Ile Leu 
    2420                 2425                 2430             


Arg Tyr  Glu Asn Glu Val Leu  Gln Leu Glu Glu Asp  Glu Arg Phe 
    2435                 2440                 2445             


Glu Gly  Arg Val Val Trp Asn  Gly Ser Arg Gly Thr  Lys Asp Leu 
    2450                 2455                 2460             


Gln Asp  Leu Ser Ile Phe Ile  Thr Asn Val Thr Tyr  Asn His Ser 
    2465                 2470                 2475             


Gly Asp  Tyr Glu Cys His Val  Tyr Arg Leu Leu Phe  Phe Glu Asn 
    2480                 2485                 2490             


Tyr Glu  His Asn Thr Ser Val  Val Lys Lys Ile His  Ile Glu Val 
    2495                 2500                 2505             


Val Asp  Lys Ala Asn Arg Asp  Met Ala Ser Ile Val  Ser Glu Ile 
    2510                 2515                 2520             


Met Met  Tyr Val Leu Ile Val  Val Leu Thr Ile Trp  Leu Val Ala 
    2525                 2530                 2535             


Glu Met  Ile Tyr Cys Tyr Lys  Lys Ile Ala Ala Ala  Thr Glu Thr 
    2540                 2545                 2550             


Ala Ala  Gln Glu Asn Ala Ser  Glu Tyr Leu Ala Ile  Thr Ser Glu 
    2555                 2560                 2565             


Ser Lys  Glu Asn Cys Thr Gly  Val Gln Val Ala Glu  Gly Ser Gly 
    2570                 2575                 2580             


Ala Thr  Asn Phe Ser Leu Leu  Lys Gln Ala Gly Asp  Val Glu Glu 
    2585                 2590                 2595             


Asn Pro  Gly Pro Met His Arg  Asp Ala Trp Leu Pro  Arg Pro Ala 
    2600                 2605                 2610             


Phe Ser  Leu Thr Gly Leu Ser  Leu Phe Phe Ser Leu  Val Pro Pro 
    2615                 2620                 2625             


Gly Arg  Ser Met Glu Val Thr  Val Pro Ala Thr Leu  Asn Val Leu 
    2630                 2635                 2640             


Asn Gly  Ser Asp Ala Arg Leu  Pro Cys Thr Phe Asn  Ser Cys Tyr 
    2645                 2650                 2655             


Thr Val  Asn His Lys Gln Phe  Ser Leu Asn Trp Thr  Tyr Gln Glu 
    2660                 2665                 2670             


Cys Asn  Asn Cys Ser Glu Glu  Met Phe Leu Gln Phe  Arg Met Lys 
    2675                 2680                 2685             


Ile Ile  Asn Leu Lys Leu Glu  Arg Phe Gln Asp Arg  Val Glu Phe 
    2690                 2695                 2700             


Ser Gly  Asn Pro Ser Lys Tyr  Asp Val Ser Val Met  Leu Arg Asn 
    2705                 2710                 2715             


Val Gln  Pro Glu Asp Glu Gly  Ile Tyr Asn Cys Tyr  Ile Met Asn 
    2720                 2725                 2730             


Pro Pro  Asp Arg His Arg Gly  His Gly Lys Ile His  Leu Gln Val 
    2735                 2740                 2745             


Leu Met  Glu Glu Pro Pro Glu  Arg Asp Ser Thr Val  Ala Val Ile 
    2750                 2755                 2760             


Val Gly  Ala Ser Val Gly Gly  Phe Leu Ala Val Val  Ile Leu Val 
    2765                 2770                 2775             


Leu Met  Val Val Lys Cys Val  Arg Arg Lys Lys Glu  Gln Lys Leu 
    2780                 2785                 2790             


Ser Thr  Asp Asp Leu Lys Thr  Glu Glu Glu Gly Lys  Thr Asp Gly 
    2795                 2800                 2805             


Glu Gly  Asn Pro Asp Asp Gly  Ala Lys Gly Ser Gly  Ala Thr Asn 
    2810                 2815                 2820             


Phe Ser  Leu Leu Lys Gln Ala  Gly Asp Val Glu Glu  Asn Pro Gly 
    2825                 2830                 2835             


Pro Met  Pro Ala Phe Asn Arg  Leu Phe Pro Leu Ala  Ser Leu Val 
    2840                 2845                 2850             


Leu Ile  Tyr Trp Val Ser Val  Cys Phe Pro Val Cys  Val Glu Val 
    2855                 2860                 2865             


Pro Ser  Glu Thr Glu Ala Val  Gln Gly Asn Pro Met  Lys Leu Arg 
    2870                 2875                 2880             


Cys Ile  Ser Cys Met Lys Arg  Glu Glu Val Glu Ala  Thr Thr Val 
    2885                 2890                 2895             


Val Glu  Trp Phe Tyr Arg Pro  Glu Gly Gly Lys Asp  Phe Leu Ile 
    2900                 2905                 2910             


Tyr Glu  Tyr Arg Asn Gly His  Gln Glu Val Glu Ser  Pro Phe Gln 
    2915                 2920                 2925             


Gly Arg  Leu Gln Trp Asn Gly  Ser Lys Asp Leu Gln  Asp Val Ser 
    2930                 2935                 2940             


Ile Thr  Val Leu Asn Val Thr  Leu Asn Asp Ser Gly  Leu Tyr Thr 
    2945                 2950                 2955             


Cys Asn  Val Ser Arg Glu Phe  Glu Phe Glu Ala His  Arg Pro Phe 
    2960                 2965                 2970             


Val Lys  Thr Thr Arg Leu Ile  Pro Leu Arg Val Thr  Glu Glu Ala 
    2975                 2980                 2985             


Gly Glu  Asp Phe Thr Ser Val  Val Ser Glu Ile Met  Met Tyr Ile 
    2990                 2995                 3000             


Leu Leu  Val Phe Leu Thr Leu  Trp Leu Leu Ile Glu  Met Ile Tyr 
    3005                 3010                 3015             


Cys Tyr  Arg Lys Val Ser Lys  Ala Glu Glu Ala Ala  Gln Glu Asn 
    3020                 3025                 3030             


Ala Ser  Asp Tyr Leu Ala Ile  Pro Ser Glu Asn Lys  Glu Asn Ser 
    3035                 3040                 3045             


Ala Val  Pro Val Glu Glu Asn  
    3050                 3055 


<210>  10
<211>  1992
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav157 chimera 1

<400>  10

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 
                645                 650                 655     


Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 
            660                 665                 670         


Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 
        675                 680                 685             


Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 
    690                 695                 700                 


Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 
705                 710                 715                 720 


Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 
                725                 730                 735     


Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
            740                 745                 750         


Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 
        755                 760                 765             


Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 
    770                 775                 780                 


Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 
785                 790                 795                 800 


Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 
                805                 810                 815     


Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
            820                 825                 830         


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
        835                 840                 845             


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
    850                 855                 860                 


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
865                 870                 875                 880 


Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 
                885                 890                 895     


Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
            900                 905                 910         


Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
        915                 920                 925             


Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 
    930                 935                 940                 


Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
945                 950                 955                 960 


Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn 
                965                 970                 975     


Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 
            980                 985                 990         


Gln Thr Leu Arg Glu Phe Ile Leu  Lys Ala Phe Ser Lys  Lys Pro Lys 
        995                 1000                 1005             


Ile Ser  Arg Glu Ile Arg Gln  Ala Glu Asp Leu Asn  Thr Lys Lys 
    1010                 1015                 1020             


Glu Asn  Tyr Ile Ser Asn His  Thr Leu Ala Glu Met  Ser Lys Gly 
    1025                 1030                 1035             


His Asn  Phe Leu Lys Glu Lys  Asp Lys Ile Ser Gly  Phe Gly Ser 
    1040                 1045                 1050             


Ser Val  Asp Lys His Leu Met  Glu Asp Ser Asp Gly  Gln Ser Phe 
    1055                 1060                 1065             


Ile His  Asn Pro Ser Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly 
    1070                 1075                 1080             


Glu Ser  Asp Leu Glu Asn Met  Asn Ala Glu Glu Leu  Ser Ser Asp 
    1085                 1090                 1095             


Ser Asp  Ser Glu Tyr Ser Lys  Val Arg Leu Asn Arg  Ser Ser Ser 
    1100                 1105                 1110             


Ser Glu  Cys Ser Thr Val Asp  Asn Pro Leu Pro Gly  Glu Gly Glu 
    1115                 1120                 1125             


Glu Ala  Glu Ala Glu Pro Met  Asn Ser Asp Glu Pro  Glu Ala Cys 
    1130                 1135                 1140             


Phe Thr  Asp Gly Cys Val Arg  Arg Phe Ser Cys Cys  Gln Val Asn 
    1145                 1150                 1155             


Ile Glu  Ser Gly Lys Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr 
    1160                 1165                 1170             


Cys Tyr  Lys Ile Val Glu His  Ser Trp Phe Glu Ser  Phe Ile Val 
    1175                 1180                 1185             


Leu Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1190                 1195                 1200             


Tyr Ile  Glu Arg Lys Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala 
    1205                 1210                 1215             


Asp Lys  Ile Phe Thr Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys 
    1220                 1225                 1230             


Trp Ile  Ala Tyr Gly Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys 
    1235                 1240                 1245             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Leu Val  Thr Leu Val 
    1250                 1255                 1260             


Ala Asn  Thr Leu Gly Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu 
    1265                 1270                 1275             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1280                 1285                 1290             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro 
    1295                 1300                 1305             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1310                 1315                 1320             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu 
    1325                 1330                 1335             


Cys Ile  Asn Thr Thr Asp Gly  Ser Arg Phe Pro Ala  Ser Gln Val 
    1340                 1345                 1350             


Pro Asn  Arg Ser Glu Cys Phe  Ala Leu Met Asn Val  Ser Gln Asn 
    1355                 1360                 1365             


Val Arg  Trp Lys Asn Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu 
    1370                 1375                 1380             


Gly Tyr  Leu Ser Leu Leu Gln  Val Ala Thr Phe Lys  Gly Trp Thr 
    1385                 1390                 1395             


Ile Ile  Met Tyr Ala Ala Val  Asp Ser Val Asn Val  Asp Lys Gln 
    1400                 1405                 1410             


Pro Lys  Tyr Glu Tyr Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Val 
    1415                 1420                 1425             


Phe Ile  Ile Phe Gly Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly 
    1430                 1435                 1440             


Val Ile  Ile Asp Asn Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly 
    1445                 1450                 1455             


Gln Asp  Ile Phe Met Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala 
    1460                 1465                 1470             


Met Lys  Lys Leu Gly Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg 
    1475                 1480                 1485             


Pro Leu  Asn Lys Tyr Gln Gly  Phe Ile Phe Asp Ile  Val Thr Lys 
    1490                 1495                 1500             


Gln Ala  Phe Asp Val Thr Ile  Met Phe Leu Ile Cys  Leu Asn Met 
    1505                 1510                 1515             


Val Thr  Met Met Val Glu Thr  Asp Asp Gln Ser Pro  Glu Lys Ile 
    1520                 1525                 1530             


Asn Ile  Leu Ala Lys Ile Asn  Leu Leu Phe Val Ala  Ile Phe Thr 
    1535                 1540                 1545             


Gly Glu  Cys Ile Val Lys Leu  Ala Ala Leu Arg His  Tyr Tyr Phe 
    1550                 1555                 1560             


Thr Asn  Ser Trp Asn Ile Phe  Asp Phe Val Val Val  Ile Leu Ser 
    1565                 1570                 1575             


Ile Val  Gly Thr Val Leu Ser  Asp Ile Ile Gln Lys  Tyr Phe Phe 
    1580                 1585                 1590             


Ser Pro  Thr Leu Phe Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg 
    1595                 1600                 1605             


Ile Leu  Arg Leu Ile Arg Gly  Ala Lys Gly Ile Arg  Thr Leu Leu 
    1610                 1615                 1620             


Phe Ala  Leu Met Met Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu 
    1625                 1630                 1635             


Leu Leu  Phe Leu Val Met Phe  Ile Tyr Ser Ile Phe  Gly Met Ala 
    1640                 1645                 1650             


Asn Phe  Ala Tyr Val Lys Trp  Glu Ala Gly Ile Asp  Asp Met Phe 
    1655                 1660                 1665             


Asn Phe  Gln Thr Phe Ala Asn  Ser Met Leu Cys Leu  Phe Gln Ile 
    1670                 1675                 1680             


Thr Thr  Ser Ala Gly Trp Asp  Gly Leu Leu Ser Pro  Ile Leu Asn 
    1685                 1690                 1695             


Thr Gly  Pro Pro Tyr Cys Asp  Pro Thr Leu Pro Asn  Ser Asn Gly 
    1700                 1705                 1710             


Ser Arg  Gly Asp Cys Gly Ser  Pro Ala Val Gly Ile  Leu Phe Phe 
    1715                 1720                 1725             


Thr Thr  Tyr Ile Ile Ile Ser  Phe Leu Ile Val Val  Asn Met Tyr 
    1730                 1735                 1740             


Ile Ala  Ile Ile Leu Glu Asn  Phe Ser Val Ala Thr  Glu Glu Ser 
    1745                 1750                 1755             


Thr Glu  Pro Leu Ser Glu Asp  Asp Phe Asp Met Phe  Tyr Glu Ile 
    1760                 1765                 1770             


Trp Glu  Lys Phe Asp Pro Glu  Ala Thr Gln Phe Ile  Glu Tyr Ser 
    1775                 1780                 1785             


Val Leu  Ser Asp Phe Ala Asp  Ala Leu Ser Glu Pro  Leu Arg Ile 
    1790                 1795                 1800             


Ala Lys  Pro Asn Gln Ile Ser  Leu Ile Asn Met Asp  Leu Pro Met 
    1805                 1810                 1815             


Val Ser  Gly Asp Arg Ile His  Cys Met Asp Ile Leu  Phe Ala Phe 
    1820                 1825                 1830             


Thr Lys  Arg Val Leu Gly Glu  Ser Gly Glu Met Asp  Ala Leu Lys 
    1835                 1840                 1845             


Ile Gln  Met Glu Glu Lys Phe  Met Ala Ala Asn Pro  Ser Lys Ile 
    1850                 1855                 1860             


Ser Tyr  Glu Pro Ile Thr Thr  Thr Leu Arg Arg Lys  His Glu Glu 
    1865                 1870                 1875             


Val Ser  Ala Met Val Ile Gln  Arg Ala Phe Arg Arg  His Leu Leu 
    1880                 1885                 1890             


Gln Arg  Ser Leu Lys His Ala  Ser Phe Leu Phe Arg  Gln Gln Ala 
    1895                 1900                 1905             


Gly Ser  Gly Leu Ser Glu Glu  Asp Ala Pro Glu Arg  Glu Gly Leu 
    1910                 1915                 1920             


Ile Ala  Tyr Val Met Ser Glu  Asn Phe Ser Arg Pro  Leu Gly Pro 
    1925                 1930                 1935             


Pro Ser  Ser Ser Ser Ile Ser  Ser Thr Ser Phe Pro  Pro Ser Tyr 
    1940                 1945                 1950             


Asp Ser  Val Thr Arg Ala Thr  Ser Asp Asn Leu Gln  Val Arg Gly 
    1955                 1960                 1965             


Ser Asp  Tyr Ser His Ser Glu  Asp Leu Ala Asp Phe  Pro Pro Ser 
    1970                 1975                 1980             


Pro Asp  Arg Asp Arg Glu Ser  Ile Val 
    1985                 1990         


<210>  11
<211>  2018
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav157 chimera 2

<400>  11

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 
                645                 650                 655     


Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 
            660                 665                 670         


Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 
        675                 680                 685             


Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 
    690                 695                 700                 


Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 
705                 710                 715                 720 


Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 
                725                 730                 735     


Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
            740                 745                 750         


Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 
        755                 760                 765             


Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 
    770                 775                 780                 


Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 
785                 790                 795                 800 


Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 
                805                 810                 815     


Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
            820                 825                 830         


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
        835                 840                 845             


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
    850                 855                 860                 


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
865                 870                 875                 880 


Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 
                885                 890                 895     


Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
            900                 905                 910         


Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
        915                 920                 925             


Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 
    930                 935                 940                 


Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
945                 950                 955                 960 


Ser Ala Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn 
                965                 970                 975     


Leu Gln Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys 
            980                 985                 990         


Arg Thr Thr Trp Asp Phe Cys Cys  Gly Leu Leu Arg Gln  Arg Pro Gln 
        995                 1000                 1005             


Lys Pro  Ala Ala Leu Ala Ala  Gln Gly Gln Leu Pro  Ser Cys Ile 
    1010                 1015                 1020             


Ala Thr  Pro Tyr Ser Pro Pro  Pro Pro Glu Thr Glu  Lys Val Pro 
    1025                 1030                 1035             


Pro Thr  Arg Lys Glu Thr Arg  Phe Glu Glu Gly Glu  Gln Pro Gly 
    1040                 1045                 1050             


Gln Gly  Thr Pro Gly Asp Pro  Glu Pro Val Cys Val  Pro Ile Ala 
    1055                 1060                 1065             


Val Ala  Glu Ser Asp Thr Asp  Asp Gln Glu Glu Asp  Glu Glu Asn 
    1070                 1075                 1080             


Ser Leu  Gly Thr Glu Glu Glu  Ser Ser Lys Gln Glu  Ser Gln Pro 
    1085                 1090                 1095             


Val Ser  Gly Gly Pro Glu Ala  Pro Pro Asp Ser Arg  Thr Trp Ser 
    1100                 1105                 1110             


Gln Val  Ser Ala Thr Ala Ser  Ser Glu Ala Glu Ala  Ser Ala Ser 
    1115                 1120                 1125             


Gln Ala  Asp Trp Arg Gln Gln  Trp Lys Ala Glu Pro  Gln Ala Pro 
    1130                 1135                 1140             


Gly Cys  Gly Glu Thr Pro Glu  Asp Ser Cys Ser Glu  Gly Ser Thr 
    1145                 1150                 1155             


Ala Asp  Met Thr Asn Thr Ala  Glu Leu Leu Glu Gln  Ile Pro Asp 
    1160                 1165                 1170             


Leu Gly  Gln Asp Val Lys Asp  Pro Glu Asp Cys Phe  Thr Glu Gly 
    1175                 1180                 1185             


Cys Val  Arg Arg Cys Pro Cys  Cys Ala Val Asp Thr  Thr Gln Ala 
    1190                 1195                 1200             


Pro Gly  Lys Val Trp Trp Arg  Leu Arg Lys Thr Cys  Tyr His Ile 
    1205                 1210                 1215             


Val Glu  His Ser Trp Phe Glu  Thr Phe Ile Ile Phe  Met Ile Leu 
    1220                 1225                 1230             


Leu Ser  Ser Gly Ala Leu Ala  Phe Glu Asp Ile Tyr  Leu Glu Glu 
    1235                 1240                 1245             


Arg Lys  Thr Ile Lys Val Leu  Leu Glu Tyr Ala Asp  Lys Met Phe 
    1250                 1255                 1260             


Thr Tyr  Val Phe Val Leu Glu  Met Leu Leu Lys Trp  Val Ala Tyr 
    1265                 1270                 1275             


Gly Phe  Lys Lys Tyr Phe Thr  Asn Ala Trp Cys Trp  Leu Asp Phe 
    1280                 1285                 1290             


Leu Ile  Val Asp Val Ser Leu  Val Ser Leu Val Ala  Asn Thr Leu 
    1295                 1300                 1305             


Gly Phe  Ala Glu Met Gly Pro  Ile Lys Ser Leu Arg  Thr Leu Arg 
    1310                 1315                 1320             


Ala Leu  Arg Pro Leu Arg Ala  Leu Ser Arg Phe Glu  Gly Met Arg 
    1325                 1330                 1335             


Val Val  Val Asn Ala Leu Val  Gly Ala Ile Pro Ser  Ile Met Asn 
    1340                 1345                 1350             


Val Leu  Leu Val Cys Leu Ile  Phe Trp Leu Ile Phe  Ser Ile Met 
    1355                 1360                 1365             


Gly Val  Asn Leu Phe Ala Gly  Lys Phe Gly Arg Cys  Ile Asn Gln 
    1370                 1375                 1380             


Thr Glu  Gly Asp Leu Pro Leu  Asn Tyr Thr Ile Val  Asn Asn Lys 
    1385                 1390                 1395             


Ser Gln  Cys Glu Ser Leu Asn  Leu Thr Gly Glu Leu  Tyr Trp Thr 
    1400                 1405                 1410             


Lys Val  Lys Val Asn Phe Asp  Asn Val Gly Ala Gly  Tyr Leu Ala 
    1415                 1420                 1425             


Leu Leu  Gln Val Ala Thr Phe  Lys Gly Trp Met Asp  Ile Met Tyr 
    1430                 1435                 1440             


Ala Ala  Val Asp Ser Arg Gly  Tyr Glu Glu Gln Pro  Gln Trp Glu 
    1445                 1450                 1455             


Tyr Asn  Leu Tyr Met Tyr Ile  Tyr Phe Val Ile Phe  Ile Ile Phe 
    1460                 1465                 1470             


Gly Ser  Phe Phe Thr Leu Asn  Leu Phe Ile Gly Val  Ile Ile Asp 
    1475                 1480                 1485             


Asn Phe  Asn Gln Gln Lys Lys  Lys Leu Gly Gly Gln  Asp Ile Phe 
    1490                 1495                 1500             


Met Thr  Glu Glu Gln Lys Lys  Tyr Tyr Asn Ala Met  Lys Lys Leu 
    1505                 1510                 1515             


Gly Ser  Lys Lys Pro Gln Lys  Pro Ile Pro Arg Pro  Gly Asn Lys 
    1520                 1525                 1530             


Ile Gln  Gly Cys Ile Phe Asp  Leu Val Thr Asn Gln  Ala Phe Asp 
    1535                 1540                 1545             


Ile Ser  Ile Met Val Leu Ile  Cys Leu Asn Met Val  Thr Met Met 
    1550                 1555                 1560             


Val Glu  Lys Glu Gly Gln Ser  Gln His Met Thr Glu  Val Leu Tyr 
    1565                 1570                 1575             


Trp Ile  Asn Val Val Phe Ile  Ile Leu Phe Thr Gly  Glu Cys Val 
    1580                 1585                 1590             


Leu Lys  Leu Ile Ser Leu Arg  His Tyr Tyr Phe Thr  Val Gly Trp 
    1595                 1600                 1605             


Asn Ile  Phe Asp Phe Val Val  Val Ile Ile Ser Ile  Val Gly Met 
    1610                 1615                 1620             


Phe Leu  Ala Asp Leu Ile Glu  Thr Tyr Phe Val Ser  Pro Thr Leu 
    1625                 1630                 1635             


Phe Arg  Val Ile Arg Leu Ala  Arg Ile Gly Arg Ile  Leu Arg Leu 
    1640                 1645                 1650             


Val Lys  Gly Ala Lys Gly Ile  Arg Thr Leu Leu Phe  Ala Leu Met 
    1655                 1660                 1665             


Met Ser  Leu Pro Ala Leu Phe  Asn Ile Gly Leu Leu  Leu Phe Leu 
    1670                 1675                 1680             


Val Met  Phe Ile Tyr Ala Ile  Phe Gly Met Ser Asn  Phe Ala Tyr 
    1685                 1690                 1695             


Val Lys  Lys Glu Asp Gly Ile  Asn Asp Met Phe Asn  Phe Glu Thr 
    1700                 1705                 1710             


Phe Gly  Asn Ser Met Ile Cys  Leu Phe Gln Ile Thr  Thr Ser Ala 
    1715                 1720                 1725             


Gly Trp  Asp Gly Leu Leu Ala  Pro Ile Leu Asn Ser  Lys Pro Pro 
    1730                 1735                 1740             


Asp Cys  Asp Pro Lys Lys Val  His Pro Gly Ser Ser  Val Glu Gly 
    1745                 1750                 1755             


Asp Cys  Gly Asn Pro Ser Val  Gly Ile Phe Tyr Phe  Val Ser Tyr 
    1760                 1765                 1770             


Ile Ile  Ile Ser Phe Leu Val  Val Val Asn Met Tyr  Ile Ala Val 
    1775                 1780                 1785             


Ile Leu  Glu Asn Phe Ser Val  Ala Thr Glu Glu Ser  Thr Glu Pro 
    1790                 1795                 1800             


Leu Ser  Glu Asp Asp Phe Glu  Met Phe Tyr Glu Val  Trp Glu Lys 
    1805                 1810                 1815             


Phe Asp  Pro Asp Ala Thr Gln  Phe Ile Glu Phe Ser  Lys Leu Ser 
    1820                 1825                 1830             


Asp Phe  Ala Ala Ala Leu Asp  Pro Pro Leu Leu Ile  Ala Lys Pro 
    1835                 1840                 1845             


Asn Lys  Val Gln Leu Ile Ala  Met Asp Leu Pro Met  Val Ser Gly 
    1850                 1855                 1860             


Asp Arg  Ile His Cys Leu Asp  Ile Leu Phe Ala Phe  Thr Lys Arg 
    1865                 1870                 1875             


Val Leu  Gly Glu Ser Gly Glu  Met Asp Ser Leu Arg  Ser Gln Met 
    1880                 1885                 1890             


Glu Glu  Arg Phe Met Ser Ala  Asn Pro Ser Lys Val  Ser Tyr Glu 
    1895                 1900                 1905             


Pro Ile  Thr Thr Thr Leu Lys  Arg Lys Gln Glu Asp  Val Ser Ala 
    1910                 1915                 1920             


Thr Val  Ile Gln Arg Ala Tyr  Arg Arg Tyr Arg Leu  Arg Gln Asn 
    1925                 1930                 1935             


Val Lys  Asn Ile Ser Ser Ile  Tyr Ile Lys Asp Gly  Asp Arg Asp 
    1940                 1945                 1950             


Asp Asp  Leu Leu Asn Lys Lys  Asp Met Ala Phe Asp  Asn Val Asn 
    1955                 1960                 1965             


Glu Asn  Ser Ser Pro Glu Lys  Thr Asp Ala Thr Ser  Ser Thr Thr 
    1970                 1975                 1980             


Ser Pro  Pro Ser Tyr Asp Ser  Val Thr Lys Pro Asp  Lys Glu Lys 
    1985                 1990                 1995             


Tyr Glu  Gln Asp Arg Thr Glu  Lys Glu Asp Lys Gly  Lys Asp Ser 
    2000                 2005                 2010             


Lys Glu  Ser Lys Lys 
    2015             


<210>  12
<211>  1948
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav157 chimera 3

<400>  12

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr 
                405                 410                 415     


Glu Glu Lys Glu Lys Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys 
            420                 425                 430         


Glu His Glu Ala Leu Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser 
        435                 440                 445             


Ser Leu Glu Met Ser Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg 
    450                 455                 460                 


Ser Lys Arg Arg Lys Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu 
465                 470                 475                 480 


Asp Arg Leu Pro Lys Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn 
                485                 490                 495     


His Leu Ser Leu Thr Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg 
            500                 505                 510         


Ser Ser Arg Gly Ser Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser 
        515                 520                 525             


Glu Ala Asp Phe Ala Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu 
    530                 535                 540                 


Ser His His Thr Ser Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser 
545                 550                 555                 560 


Ala Gln Gly Gln Pro Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu 
                565                 570                 575     


His Gly Lys Lys Asn Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu 
            580                 585                 590         


Leu Gly Ala Gly Asp Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu 
        595                 600                 605             


Arg Pro Val Met Leu Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu 
    610                 615                 620                 


Glu Pro Gly Gly Pro Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp 
625                 630                 635                 640 


Gly Phe Glu Glu Pro Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser 
                645                 650                 655     


Val Leu Thr Ser Ala Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys 
            660                 665                 670         


Pro Pro Cys Trp Asn Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys 
        675                 680                 685             


Cys Pro Leu Trp Met Ser Ile Lys Gln Gly Val Lys Leu Val Val Met 
    690                 695                 700                 


Asp Pro Phe Thr Asp Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr 
705                 710                 715                 720 


Leu Phe Met Ala Leu Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu 
                725                 730                 735     


Met Leu Gln Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu 
            740                 745                 750         


Met Thr Phe Lys Ile Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln 
        755                 760                 765             


Gly Trp Asn Ile Phe Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu 
    770                 775                 780                 


Leu Gly Leu Ser Arg Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg 
785                 790                 795                 800 


Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr 
                805                 810                 815     


Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr 
            820                 825                 830         


Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln 
        835                 840                 845             


Leu Phe Gly Lys Asn Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu 
    850                 855                 860                 


Leu Pro Arg Trp His Met Met Asp Phe Phe His Ala Phe Leu Ile Ile 
865                 870                 875                 880 


Phe Arg Ile Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
                885                 890                 895     


Glu Val Ser Gly Gln Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met 
            900                 905                 910         


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
        915                 920                 925             


Ser Ser Phe Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp 
    930                 935                 940                 


Ala Asn Asn Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn 
945                 950                 955                 960 


Tyr Val Lys Gln Thr Leu Arg Glu Phe Ile Leu Lys Ala Phe Ser Lys 
                965                 970                 975     


Lys Pro Lys Ile Ser Arg Glu Ile Arg Gln Ala Glu Asp Leu Asn Thr 
            980                 985                 990         


Lys Lys Glu Asn Tyr Ile Ser Asn  His Thr Leu Ala Glu  Met Ser Lys 
        995                 1000                 1005             


Gly His  Asn Phe Leu Lys Glu  Lys Asp Lys Ile Ser  Gly Phe Gly 
    1010                 1015                 1020             


Ser Ser  Val Asp Lys His Leu  Met Glu Asp Ser Asp  Gly Gln Ser 
    1025                 1030                 1035             


Phe Ile  His Asn Pro Ser Leu  Thr Val Thr Val Pro  Ile Ala Pro 
    1040                 1045                 1050             


Gly Glu  Ser Asp Leu Glu Asn  Met Asn Ala Glu Glu  Leu Ser Ser 
    1055                 1060                 1065             


Asp Ser  Asp Ser Glu Tyr Ser  Lys Val Arg Leu Asn  Arg Ser Ser 
    1070                 1075                 1080             


Ser Ser  Glu Cys Ser Thr Val  Asp Asn Pro Leu Pro  Gly Glu Gly 
    1085                 1090                 1095             


Glu Glu  Ala Glu Ala Glu Pro  Met Asn Ser Asp Glu  Pro Glu Ala 
    1100                 1105                 1110             


Cys Phe  Thr Asp Gly Cys Val  Arg Arg Phe Ser Cys  Cys Gln Val 
    1115                 1120                 1125             


Asn Ile  Glu Ser Gly Lys Gly  Lys Ile Trp Trp Asn  Ile Arg Lys 
    1130                 1135                 1140             


Thr Cys  Tyr Lys Ile Val Glu  His Ser Trp Phe Glu  Ser Phe Ile 
    1145                 1150                 1155             


Val Leu  Met Ile Leu Leu Ser  Ser Gly Ala Leu Ala  Phe Glu Asp 
    1160                 1165                 1170             


Ile Tyr  Ile Glu Arg Lys Lys  Thr Ile Lys Ile Ile  Leu Glu Tyr 
    1175                 1180                 1185             


Ala Asp  Lys Ile Phe Thr Tyr  Ile Phe Ile Leu Glu  Met Leu Leu 
    1190                 1195                 1200             


Lys Trp  Ile Ala Tyr Gly Tyr  Lys Thr Tyr Phe Thr  Asn Ala Trp 
    1205                 1210                 1215             


Cys Trp  Leu Asp Phe Leu Ile  Val Asp Val Ser Leu  Val Thr Leu 
    1220                 1225                 1230             


Val Ala  Asn Thr Leu Gly Tyr  Ser Asp Leu Gly Pro  Ile Lys Ser 
    1235                 1240                 1245             


Leu Arg  Thr Leu Arg Ala Leu  Arg Pro Leu Arg Ala  Leu Ser Arg 
    1250                 1255                 1260             


Phe Glu  Gly Met Arg Val Val  Val Asn Ala Leu Ile  Gly Ala Ile 
    1265                 1270                 1275             


Pro Ser  Ile Met Asn Val Leu  Leu Val Cys Leu Ile  Phe Trp Leu 
    1280                 1285                 1290             


Ile Phe  Ser Ile Met Gly Val  Asn Leu Phe Ala Gly  Lys Phe Tyr 
    1295                 1300                 1305             


Glu Cys  Ile Asn Thr Thr Asp  Gly Ser Arg Phe Pro  Ala Ser Gln 
    1310                 1315                 1320             


Val Pro  Asn Arg Ser Glu Cys  Phe Ala Leu Met Asn  Val Ser Gln 
    1325                 1330                 1335             


Asn Val  Arg Trp Lys Asn Leu  Lys Val Asn Phe Asp  Asn Val Gly 
    1340                 1345                 1350             


Leu Gly  Tyr Leu Ser Leu Leu  Gln Val Ala Thr Phe  Lys Gly Trp 
    1355                 1360                 1365             


Thr Ile  Ile Met Tyr Ala Ala  Val Asp Ser Val Asn  Val Asp Lys 
    1370                 1375                 1380             


Gln Pro  Lys Tyr Glu Tyr Ser  Leu Tyr Met Tyr Ile  Tyr Phe Val 
    1385                 1390                 1395             


Val Phe  Ile Ile Phe Gly Ser  Phe Phe Thr Leu Asn  Leu Phe Ile 
    1400                 1405                 1410             


Gly Val  Ile Ile Asp Asn Phe  Asn Gln Gln Lys Lys  Lys Leu Gly 
    1415                 1420                 1425             


Gly Gln  Asp Ile Phe Met Thr  Glu Glu Gln Lys Lys  Tyr Tyr Asn 
    1430                 1435                 1440             


Ala Met  Lys Lys Leu Gly Ser  Lys Lys Pro Gln Lys  Pro Ile Pro 
    1445                 1450                 1455             


Arg Pro  Gly Asn Lys Ile Gln  Gly Cys Ile Phe Asp  Leu Val Thr 
    1460                 1465                 1470             


Asn Gln  Ala Phe Asp Ile Ser  Ile Met Val Leu Ile  Cys Leu Asn 
    1475                 1480                 1485             


Met Val  Thr Met Met Val Glu  Lys Glu Gly Gln Ser  Gln His Met 
    1490                 1495                 1500             


Thr Glu  Val Leu Tyr Trp Ile  Asn Val Val Phe Ile  Ile Leu Phe 
    1505                 1510                 1515             


Thr Gly  Glu Cys Val Leu Lys  Leu Ile Ser Leu Arg  His Tyr Tyr 
    1520                 1525                 1530             


Phe Thr  Val Gly Trp Asn Ile  Phe Asp Phe Val Val  Val Ile Ile 
    1535                 1540                 1545             


Ser Ile  Val Gly Met Phe Leu  Ala Asp Leu Ile Glu  Thr Tyr Phe 
    1550                 1555                 1560             


Val Ser  Pro Thr Leu Phe Arg  Val Ile Arg Leu Ala  Arg Ile Gly 
    1565                 1570                 1575             


Arg Ile  Leu Arg Leu Val Lys  Gly Ala Lys Gly Ile  Arg Thr Leu 
    1580                 1585                 1590             


Leu Phe  Ala Leu Met Met Ser  Leu Pro Ala Leu Phe  Asn Ile Gly 
    1595                 1600                 1605             


Leu Leu  Leu Phe Leu Val Met  Phe Ile Tyr Ala Ile  Phe Gly Met 
    1610                 1615                 1620             


Ser Asn  Phe Ala Tyr Val Lys  Lys Glu Asp Gly Ile  Asn Asp Met 
    1625                 1630                 1635             


Phe Asn  Phe Glu Thr Phe Gly  Asn Ser Met Ile Cys  Leu Phe Gln 
    1640                 1645                 1650             


Ile Thr  Thr Ser Ala Gly Trp  Asp Gly Leu Leu Ala  Pro Ile Leu 
    1655                 1660                 1665             


Asn Ser  Lys Pro Pro Asp Cys  Asp Pro Lys Lys Val  His Pro Gly 
    1670                 1675                 1680             


Ser Ser  Val Glu Gly Asp Cys  Gly Asn Pro Ser Val  Gly Ile Phe 
    1685                 1690                 1695             


Tyr Phe  Val Ser Tyr Ile Ile  Ile Ser Phe Leu Val  Val Val Asn 
    1700                 1705                 1710             


Met Tyr  Ile Ala Val Ile Leu  Glu Asn Phe Ser Val  Ala Thr Glu 
    1715                 1720                 1725             


Glu Ser  Thr Glu Pro Leu Ser  Glu Asp Asp Phe Glu  Met Phe Tyr 
    1730                 1735                 1740             


Glu Val  Trp Glu Lys Phe Asp  Pro Asp Ala Thr Gln  Phe Ile Glu 
    1745                 1750                 1755             


Phe Ser  Lys Leu Ser Asp Phe  Ala Ala Ala Leu Asp  Pro Pro Leu 
    1760                 1765                 1770             


Leu Ile  Ala Lys Pro Asn Lys  Val Gln Leu Ile Ala  Met Asp Leu 
    1775                 1780                 1785             


Pro Met  Val Ser Gly Asp Arg  Ile His Cys Leu Asp  Ile Leu Phe 
    1790                 1795                 1800             


Ala Phe  Thr Lys Arg Val Leu  Gly Glu Ser Gly Glu  Met Asp Ser 
    1805                 1810                 1815             


Leu Arg  Ser Gln Met Glu Glu  Arg Phe Met Ser Ala  Asn Pro Ser 
    1820                 1825                 1830             


Lys Val  Ser Tyr Glu Pro Ile  Thr Thr Thr Leu Lys  Arg Lys Gln 
    1835                 1840                 1845             


Glu Asp  Val Ser Ala Thr Val  Ile Gln Arg Ala Tyr  Arg Arg Tyr 
    1850                 1855                 1860             


Arg Leu  Arg Gln Asn Val Lys  Asn Ile Ser Ser Ile  Tyr Ile Lys 
    1865                 1870                 1875             


Asp Gly  Asp Arg Asp Asp Asp  Leu Leu Asn Lys Lys  Asp Met Ala 
    1880                 1885                 1890             


Phe Asp  Asn Val Asn Glu Asn  Ser Ser Pro Glu Lys  Thr Asp Ala 
    1895                 1900                 1905             


Thr Ser  Ser Thr Thr Ser Pro  Pro Ser Tyr Asp Ser  Val Thr Lys 
    1910                 1915                 1920             


Pro Asp  Lys Glu Lys Tyr Glu  Gln Asp Arg Thr Glu  Lys Glu Asp 
    1925                 1930                 1935             


Lys Gly  Lys Asp Ser Lys Glu  Ser Lys Lys 
    1940                 1945             


<210>  13
<211>  1988
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav157 chimera 4

<400>  13

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala Lys Gln Lys Glu Leu 
            420                 425                 430         


Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys Glu Gln Glu Glu Ala 
        435                 440                 445             


Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr Ser Ile Arg Arg Ser 
    450                 455                 460                 


Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu Thr Ser Lys Leu Ser 
465                 470                 475                 480 


Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Lys Lys Lys Asn Gln 
                485                 490                 495     


Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp Ala Glu Lys Leu Ser 
            500                 505                 510         


Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys Ser Phe His Leu Gly 
        515                 520                 525             


Val Glu Gly His Arg Arg Ala His Glu Lys Arg Leu Ser Thr Pro Asn 
    530                 535                 540                 


Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe Ser Ala Arg Arg Ser 
545                 550                 555                 560 


Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg Gly Arg Asp Ile Gly 
                565                 570                 575     


Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile Phe Gly Asp Asn 
            580                 585                 590         


Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His Arg Pro Gln Glu Arg 
        595                 600                 605             


Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser Pro Pro Met Leu Pro 
    610                 615                 620                 


Val Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser 
625                 630                 635                 640 


Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro Asn Gly Gln Leu Leu 
                645                 650                 655     


Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys Arg Arg Cys Ser Ser 
            660                 665                 670         


Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro Asn Leu Arg Gln Arg 
        675                 680                 685             


Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu 
    690                 695                 700                 


Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Lys 
705                 710                 715                 720 


Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Cys 
                725                 730                 735     


Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
            740                 745                 750         


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met 
        755                 760                 765             


Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly Asn Leu Val Phe Thr 
    770                 775                 780                 


Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro 
785                 790                 795                 800 


Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val 
                805                 810                 815     


Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser 
            820                 825                 830         


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
        835                 840                 845             


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
    850                 855                 860                 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
865                 870                 875                 880 


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
                885                 890                 895     


Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp 
            900                 905                 910         


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
        915                 920                 925             


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys 
    930                 935                 940                 


Leu Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
945                 950                 955                 960 


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
                965                 970                 975     


Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn Leu Gln Ile Ala Val 
            980                 985                 990         


Thr Arg Ile Lys Lys Gly Ile Asn  Tyr Val Lys Gln Thr  Leu Arg Glu 
        995                 1000                 1005             


Phe Ile  Leu Lys Ala Phe Ser  Lys Lys Pro Lys Ile  Ser Arg Glu 
    1010                 1015                 1020             


Ile Arg  Gln Ala Glu Asp Leu  Asn Thr Lys Lys Glu  Asn Tyr Ile 
    1025                 1030                 1035             


Ser Asn  His Thr Leu Ala Glu  Met Ser Lys Gly His  Asn Phe Leu 
    1040                 1045                 1050             


Lys Glu  Lys Asp Lys Ile Ser  Gly Phe Gly Ser Ser  Val Asp Lys 
    1055                 1060                 1065             


His Leu  Met Glu Asp Ser Asp  Gly Gln Ser Phe Ile  His Asn Pro 
    1070                 1075                 1080             


Ser Leu  Thr Val Thr Val Pro  Ile Ala Pro Gly Glu  Ser Asp Leu 
    1085                 1090                 1095             


Glu Asn  Met Asn Ala Glu Glu  Leu Ser Ser Asp Ser  Asp Ser Glu 
    1100                 1105                 1110             


Tyr Ser  Lys Val Arg Leu Asn  Arg Ser Ser Ser Ser  Glu Cys Ser 
    1115                 1120                 1125             


Thr Val  Asp Asn Pro Leu Pro  Gly Glu Gly Glu Glu  Ala Glu Ala 
    1130                 1135                 1140             


Glu Pro  Met Asn Ser Asp Glu  Pro Glu Ala Cys Phe  Thr Asp Gly 
    1145                 1150                 1155             


Cys Val  Arg Arg Phe Ser Cys  Cys Gln Val Asn Ile  Glu Ser Gly 
    1160                 1165                 1170             


Lys Gly  Lys Ile Trp Trp Asn  Ile Arg Lys Thr Cys  Tyr Lys Ile 
    1175                 1180                 1185             


Val Glu  His Ser Trp Phe Glu  Ser Phe Ile Val Leu  Met Ile Leu 
    1190                 1195                 1200             


Leu Ser  Ser Gly Ala Leu Ala  Phe Glu Asp Ile Tyr  Ile Glu Arg 
    1205                 1210                 1215             


Lys Lys  Thr Ile Lys Ile Ile  Leu Glu Tyr Ala Asp  Lys Ile Phe 
    1220                 1225                 1230             


Thr Tyr  Ile Phe Ile Leu Glu  Met Leu Leu Lys Trp  Ile Ala Tyr 
    1235                 1240                 1245             


Gly Tyr  Lys Thr Tyr Phe Thr  Asn Ala Trp Cys Trp  Leu Asp Phe 
    1250                 1255                 1260             


Leu Ile  Val Asp Val Ser Leu  Val Thr Leu Val Ala  Asn Thr Leu 
    1265                 1270                 1275             


Gly Tyr  Ser Asp Leu Gly Pro  Ile Lys Ser Leu Arg  Thr Leu Arg 
    1280                 1285                 1290             


Ala Leu  Arg Pro Leu Arg Ala  Leu Ser Arg Phe Glu  Gly Met Arg 
    1295                 1300                 1305             


Val Val  Val Asn Ala Leu Ile  Gly Ala Ile Pro Ser  Ile Met Asn 
    1310                 1315                 1320             


Val Leu  Leu Val Cys Leu Ile  Phe Trp Leu Ile Phe  Ser Ile Met 
    1325                 1330                 1335             


Gly Val  Asn Leu Phe Ala Gly  Lys Phe Tyr Glu Cys  Ile Asn Thr 
    1340                 1345                 1350             


Thr Asp  Gly Ser Arg Phe Pro  Ala Ser Gln Val Pro  Asn Arg Ser 
    1355                 1360                 1365             


Glu Cys  Phe Ala Leu Met Asn  Val Ser Gln Asn Val  Arg Trp Lys 
    1370                 1375                 1380             


Asn Leu  Lys Val Asn Phe Asp  Asn Val Gly Leu Gly  Tyr Leu Ser 
    1385                 1390                 1395             


Leu Leu  Gln Val Ala Thr Phe  Lys Gly Trp Thr Ile  Ile Met Tyr 
    1400                 1405                 1410             


Ala Ala  Val Asp Ser Val Asn  Val Asp Lys Gln Pro  Lys Tyr Glu 
    1415                 1420                 1425             


Tyr Ser  Leu Tyr Met Tyr Ile  Tyr Phe Val Val Phe  Ile Ile Phe 
    1430                 1435                 1440             


Gly Ser  Phe Phe Thr Leu Asn  Leu Phe Ile Gly Val  Ile Ile Asp 
    1445                 1450                 1455             


Asn Phe  Asn Gln Gln Lys Lys  Lys Leu Gly Gly Gln  Asp Ile Phe 
    1460                 1465                 1470             


Met Thr  Glu Glu Gln Lys Lys  Tyr Tyr Asn Ala Met  Lys Lys Leu 
    1475                 1480                 1485             


Gly Ser  Lys Lys Pro Gln Lys  Pro Ile Pro Arg Pro  Gly Asn Lys 
    1490                 1495                 1500             


Ile Gln  Gly Cys Ile Phe Asp  Leu Val Thr Asn Gln  Ala Phe Asp 
    1505                 1510                 1515             


Ile Ser  Ile Met Val Leu Ile  Cys Leu Asn Met Val  Thr Met Met 
    1520                 1525                 1530             


Val Glu  Lys Glu Gly Gln Ser  Gln His Met Thr Glu  Val Leu Tyr 
    1535                 1540                 1545             


Trp Ile  Asn Val Val Phe Ile  Ile Leu Phe Thr Gly  Glu Cys Val 
    1550                 1555                 1560             


Leu Lys  Leu Ile Ser Leu Arg  His Tyr Tyr Phe Thr  Val Gly Trp 
    1565                 1570                 1575             


Asn Ile  Phe Asp Phe Val Val  Val Ile Ile Ser Ile  Val Gly Met 
    1580                 1585                 1590             


Phe Leu  Ala Asp Leu Ile Glu  Thr Tyr Phe Val Ser  Pro Thr Leu 
    1595                 1600                 1605             


Phe Arg  Val Ile Arg Leu Ala  Arg Ile Gly Arg Ile  Leu Arg Leu 
    1610                 1615                 1620             


Val Lys  Gly Ala Lys Gly Ile  Arg Thr Leu Leu Phe  Ala Leu Met 
    1625                 1630                 1635             


Met Ser  Leu Pro Ala Leu Phe  Asn Ile Gly Leu Leu  Leu Phe Leu 
    1640                 1645                 1650             


Val Met  Phe Ile Tyr Ala Ile  Phe Gly Met Ser Asn  Phe Ala Tyr 
    1655                 1660                 1665             


Val Lys  Lys Glu Asp Gly Ile  Asn Asp Met Phe Asn  Phe Glu Thr 
    1670                 1675                 1680             


Phe Gly  Asn Ser Met Ile Cys  Leu Phe Gln Ile Thr  Thr Ser Ala 
    1685                 1690                 1695             


Gly Trp  Asp Gly Leu Leu Ala  Pro Ile Leu Asn Ser  Lys Pro Pro 
    1700                 1705                 1710             


Asp Cys  Asp Pro Lys Lys Val  His Pro Gly Ser Ser  Val Glu Gly 
    1715                 1720                 1725             


Asp Cys  Gly Asn Pro Ser Val  Gly Ile Phe Tyr Phe  Val Ser Tyr 
    1730                 1735                 1740             


Ile Ile  Ile Ser Phe Leu Val  Val Val Asn Met Tyr  Ile Ala Val 
    1745                 1750                 1755             


Ile Leu  Glu Asn Phe Ser Val  Ala Thr Glu Glu Ser  Thr Glu Pro 
    1760                 1765                 1770             


Leu Ser  Glu Asp Asp Phe Glu  Met Phe Tyr Glu Val  Trp Glu Lys 
    1775                 1780                 1785             


Phe Asp  Pro Asp Ala Thr Gln  Phe Ile Glu Phe Ser  Lys Leu Ser 
    1790                 1795                 1800             


Asp Phe  Ala Ala Ala Leu Asp  Pro Pro Leu Leu Ile  Ala Lys Pro 
    1805                 1810                 1815             


Asn Lys  Val Gln Leu Ile Ala  Met Asp Leu Pro Met  Val Ser Gly 
    1820                 1825                 1830             


Asp Arg  Ile His Cys Leu Asp  Ile Leu Phe Ala Phe  Thr Lys Arg 
    1835                 1840                 1845             


Val Leu  Gly Glu Ser Gly Glu  Met Asp Ser Leu Arg  Ser Gln Met 
    1850                 1855                 1860             


Glu Glu  Arg Phe Met Ser Ala  Asn Pro Ser Lys Val  Ser Tyr Glu 
    1865                 1870                 1875             


Pro Ile  Thr Thr Thr Leu Lys  Arg Lys Gln Glu Asp  Val Ser Ala 
    1880                 1885                 1890             


Thr Val  Ile Gln Arg Ala Tyr  Arg Arg Tyr Arg Leu  Arg Gln Asn 
    1895                 1900                 1905             


Val Lys  Asn Ile Ser Ser Ile  Tyr Ile Lys Asp Gly  Asp Arg Asp 
    1910                 1915                 1920             


Asp Asp  Leu Leu Asn Lys Lys  Asp Met Ala Phe Asp  Asn Val Asn 
    1925                 1930                 1935             


Glu Asn  Ser Ser Pro Glu Lys  Thr Asp Ala Thr Ser  Ser Thr Thr 
    1940                 1945                 1950             


Ser Pro  Pro Ser Tyr Asp Ser  Val Thr Lys Pro Asp  Lys Glu Lys 
    1955                 1960                 1965             


Tyr Glu  Gln Asp Arg Thr Glu  Lys Glu Asp Lys Gly  Lys Asp Ser 
    1970                 1975                 1980             


Lys Glu  Ser Lys Lys 
    1985             


<210>  14
<211>  2000
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav157 chimera 5

<400>  14

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Glu Ser Gln Pro  Val Ser Gly 
    1070                 1075                 1080             


Gly Pro  Glu Ala Pro Pro Asp  Ser Arg Thr Trp Ser  Gln Val Ser 
    1085                 1090                 1095             


Ala Thr  Ala Ser Ser Glu Ala  Glu Ala Ser Ala Ser  Gln Ala Asp 
    1100                 1105                 1110             


Trp Arg  Gln Gln Trp Lys Ala  Glu Pro Gln Ala Pro  Gly Cys Gly 
    1115                 1120                 1125             


Glu Thr  Pro Glu Asp Ser Cys  Ser Glu Gly Ser Thr  Ala Asp Met 
    1130                 1135                 1140             


Thr Asn  Thr Ala Glu Leu Leu  Glu Gln Ile Pro Asp  Leu Gly Gln 
    1145                 1150                 1155             


Asp Val  Lys Asp Pro Glu Asp  Cys Phe Thr Glu Gly  Cys Val Arg 
    1160                 1165                 1170             


Arg Cys  Pro Cys Cys Ala Val  Asp Thr Thr Gln Ala  Pro Gly Lys 
    1175                 1180                 1185             


Val Trp  Trp Arg Leu Arg Lys  Thr Cys Tyr His Ile  Val Glu His 
    1190                 1195                 1200             


Ser Trp  Phe Glu Thr Phe Ile  Ile Phe Met Ile Leu  Leu Ser Ser 
    1205                 1210                 1215             


Gly Ala  Leu Ala Phe Glu Asp  Ile Tyr Leu Glu Glu  Arg Lys Thr 
    1220                 1225                 1230             


Ile Lys  Val Leu Leu Glu Tyr  Ala Asp Lys Met Phe  Thr Tyr Val 
    1235                 1240                 1245             


Phe Val  Leu Glu Met Leu Leu  Lys Trp Val Ala Tyr  Gly Phe Lys 
    1250                 1255                 1260             


Lys Tyr  Phe Thr Asn Ala Trp  Cys Trp Leu Asp Phe  Leu Ile Val 
    1265                 1270                 1275             


Asp Val  Ser Leu Val Ser Leu  Val Ala Asn Thr Leu  Gly Phe Ala 
    1280                 1285                 1290             


Glu Met  Gly Pro Ile Lys Ser  Leu Arg Thr Leu Arg  Ala Leu Arg 
    1295                 1300                 1305             


Pro Leu  Arg Ala Leu Ser Arg  Phe Glu Gly Met Arg  Val Val Val 
    1310                 1315                 1320             


Asn Ala  Leu Val Gly Ala Ile  Pro Ser Ile Met Asn  Val Leu Leu 
    1325                 1330                 1335             


Val Cys  Leu Ile Phe Trp Leu  Ile Phe Ser Ile Met  Gly Val Asn 
    1340                 1345                 1350             


Leu Phe  Ala Gly Lys Phe Gly  Arg Cys Ile Asn Gln  Thr Glu Gly 
    1355                 1360                 1365             


Asp Leu  Pro Leu Asn Tyr Thr  Ile Val Asn Asn Lys  Ser Gln Cys 
    1370                 1375                 1380             


Glu Ser  Leu Asn Leu Thr Gly  Glu Leu Tyr Trp Thr  Lys Val Lys 
    1385                 1390                 1395             


Val Asn  Phe Asp Asn Val Gly  Ala Gly Tyr Leu Ala  Leu Leu Gln 
    1400                 1405                 1410             


Val Ala  Thr Phe Lys Gly Trp  Met Asp Ile Met Tyr  Ala Ala Val 
    1415                 1420                 1425             


Asp Ser  Arg Gly Tyr Glu Glu  Gln Pro Gln Trp Glu  Tyr Asn Leu 
    1430                 1435                 1440             


Tyr Met  Tyr Ile Tyr Phe Val  Ile Phe Ile Ile Phe  Gly Ser Phe 
    1445                 1450                 1455             


Phe Thr  Leu Asn Leu Phe Ile  Gly Val Ile Ile Asp  Asn Phe Asn 
    1460                 1465                 1470             


Gln Gln  Lys Lys Lys Leu Gly  Gly Gln Asp Ile Phe  Met Thr Glu 
    1475                 1480                 1485             


Glu Gln  Lys Lys Tyr Tyr Asn  Ala Met Lys Lys Leu  Gly Ser Lys 
    1490                 1495                 1500             


Lys Pro  Gln Lys Pro Ile Pro  Arg Pro Gly Asn Lys  Ile Gln Gly 
    1505                 1510                 1515             


Cys Ile  Phe Asp Leu Val Thr  Asn Gln Ala Phe Asp  Ile Ser Ile 
    1520                 1525                 1530             


Met Val  Leu Ile Cys Leu Asn  Met Val Thr Met Met  Val Glu Lys 
    1535                 1540                 1545             


Glu Gly  Gln Ser Gln His Met  Thr Glu Val Leu Tyr  Trp Ile Asn 
    1550                 1555                 1560             


Val Val  Phe Ile Ile Leu Phe  Thr Gly Glu Cys Val  Leu Lys Leu 
    1565                 1570                 1575             


Ile Ser  Leu Arg His Tyr Tyr  Phe Thr Val Gly Trp  Asn Ile Phe 
    1580                 1585                 1590             


Asp Phe  Val Val Val Ile Ile  Ser Ile Val Gly Met  Phe Leu Ala 
    1595                 1600                 1605             


Asp Leu  Ile Glu Thr Tyr Phe  Val Ser Pro Thr Leu  Phe Arg Val 
    1610                 1615                 1620             


Ile Arg  Leu Ala Arg Ile Gly  Arg Ile Leu Arg Leu  Val Lys Gly 
    1625                 1630                 1635             


Ala Lys  Gly Ile Arg Thr Leu  Leu Phe Ala Leu Met  Met Ser Leu 
    1640                 1645                 1650             


Pro Ala  Leu Phe Asn Ile Gly  Leu Leu Leu Phe Leu  Val Met Phe 
    1655                 1660                 1665             


Ile Tyr  Ala Ile Phe Gly Met  Ser Asn Phe Ala Tyr  Val Lys Lys 
    1670                 1675                 1680             


Glu Asp  Gly Ile Asn Asp Met  Phe Asn Phe Glu Thr  Phe Gly Asn 
    1685                 1690                 1695             


Ser Met  Ile Cys Leu Phe Gln  Ile Thr Thr Ser Ala  Gly Trp Asp 
    1700                 1705                 1710             


Gly Leu  Leu Ala Pro Ile Leu  Asn Ser Lys Pro Pro  Asp Cys Asp 
    1715                 1720                 1725             


Pro Lys  Lys Val His Pro Gly  Ser Ser Val Glu Gly  Asp Cys Gly 
    1730                 1735                 1740             


Asn Pro  Ser Val Gly Ile Phe  Tyr Phe Val Ser Tyr  Ile Ile Ile 
    1745                 1750                 1755             


Ser Phe  Leu Val Val Val Asn  Met Tyr Ile Ala Val  Ile Leu Glu 
    1760                 1765                 1770             


Asn Phe  Ser Val Ala Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu 
    1775                 1780                 1785             


Asp Asp  Phe Glu Met Phe Tyr  Glu Val Trp Glu Lys  Phe Asp Pro 
    1790                 1795                 1800             


Asp Ala  Thr Gln Phe Ile Glu  Phe Ser Lys Leu Ser  Asp Phe Ala 
    1805                 1810                 1815             


Ala Ala  Leu Asp Pro Pro Leu  Leu Ile Ala Lys Pro  Asn Lys Val 
    1820                 1825                 1830             


Gln Leu  Ile Ala Met Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile 
    1835                 1840                 1845             


His Cys  Leu Asp Ile Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly 
    1850                 1855                 1860             


Glu Ser  Gly Glu Met Asp Ser  Leu Arg Ser Gln Met  Glu Glu Arg 
    1865                 1870                 1875             


Phe Met  Ser Ala Asn Pro Ser  Lys Val Ser Tyr Glu  Pro Ile Thr 
    1880                 1885                 1890             


Thr Thr  Leu Lys Arg Lys Gln  Glu Asp Val Ser Ala  Thr Val Ile 
    1895                 1900                 1905             


Gln Arg  Ala Tyr Arg Arg Tyr  Arg Leu Arg Gln Asn  Val Lys Asn 
    1910                 1915                 1920             


Ile Ser  Ser Ile Tyr Ile Lys  Asp Gly Asp Arg Asp  Asp Asp Leu 
    1925                 1930                 1935             


Leu Asn  Lys Lys Asp Met Ala  Phe Asp Asn Val Asn  Glu Asn Ser 
    1940                 1945                 1950             


Ser Pro  Glu Lys Thr Asp Ala  Thr Ser Ser Thr Thr  Ser Pro Pro 
    1955                 1960                 1965             


Ser Tyr  Asp Ser Val Thr Lys  Pro Asp Lys Glu Lys  Tyr Glu Gln 
    1970                 1975                 1980             


Asp Arg  Thr Glu Lys Glu Asp  Lys Gly Lys Asp Ser  Lys Glu Ser 
    1985                 1990                 1995             


Lys Lys  
    2000 


<210>  15
<211>  1974
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav157 chimera 6

<400>  15

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser 
    930                 935                 940                 


Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn Leu Gln 
945                 950                 955                 960 


Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys Gln Thr 
                965                 970                 975     


Leu Arg Glu Phe Ile Leu Lys Ala Phe Ser Lys Lys Pro Lys Ile Ser 
            980                 985                 990         


Arg Glu Ile Arg Gln Ala Glu Asp  Leu Asn Thr Lys Lys  Glu Asn Tyr 
        995                 1000                 1005             


Ile Ser  Asn His Thr Leu Ala  Glu Met Ser Lys Gly  His Asn Phe 
    1010                 1015                 1020             


Leu Lys  Glu Lys Asp Lys Ile  Ser Gly Phe Gly Ser  Ser Val Asp 
    1025                 1030                 1035             


Lys His  Leu Met Glu Asp Ser  Asp Gly Gln Ser Phe  Ile His Asn 
    1040                 1045                 1050             


Pro Ser  Leu Thr Val Thr Val  Pro Ile Ala Pro Gly  Glu Ser Asp 
    1055                 1060                 1065             


Leu Glu  Asn Met Asn Ala Glu  Glu Leu Ser Ser Asp  Ser Asp Ser 
    1070                 1075                 1080             


Glu Tyr  Ser Lys Val Arg Leu  Asn Arg Ser Ser Ser  Ser Glu Cys 
    1085                 1090                 1095             


Ser Thr  Val Asp Asn Pro Leu  Pro Gly Glu Gly Glu  Glu Ala Glu 
    1100                 1105                 1110             


Ala Glu  Pro Met Asn Ser Asp  Glu Pro Glu Ala Cys  Phe Thr Asp 
    1115                 1120                 1125             


Gly Cys  Val Arg Arg Phe Ser  Cys Cys Gln Val Asn  Ile Glu Ser 
    1130                 1135                 1140             


Gly Lys  Gly Lys Ile Trp Trp  Asn Ile Arg Lys Thr  Cys Tyr Lys 
    1145                 1150                 1155             


Ile Val  Glu His Ser Trp Phe  Glu Ser Phe Ile Val  Leu Met Ile 
    1160                 1165                 1170             


Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Glu 
    1175                 1180                 1185             


Arg Lys  Lys Thr Ile Lys Ile  Ile Leu Glu Tyr Ala  Asp Lys Ile 
    1190                 1195                 1200             


Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu Leu Lys  Trp Ile Ala 
    1205                 1210                 1215             


Tyr Gly  Tyr Lys Thr Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp 
    1220                 1225                 1230             


Phe Leu  Ile Val Asp Val Ser  Leu Val Thr Leu Val  Ala Asn Thr 
    1235                 1240                 1245             


Leu Gly  Tyr Ser Asp Leu Gly  Pro Ile Lys Ser Leu  Arg Thr Leu 
    1250                 1255                 1260             


Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met 
    1265                 1270                 1275             


Arg Val  Val Val Asn Ala Leu  Ile Gly Ala Ile Pro  Ser Ile Met 
    1280                 1285                 1290             


Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile 
    1295                 1300                 1305             


Met Gly  Val Asn Leu Phe Ala  Gly Lys Phe Tyr Glu  Cys Ile Asn 
    1310                 1315                 1320             


Thr Thr  Asp Gly Ser Arg Phe  Pro Ala Ser Gln Val  Pro Asn Arg 
    1325                 1330                 1335             


Ser Glu  Cys Phe Ala Leu Met  Asn Val Ser Gln Asn  Val Arg Trp 
    1340                 1345                 1350             


Lys Asn  Leu Lys Val Asn Phe  Asp Asn Val Gly Leu  Gly Tyr Leu 
    1355                 1360                 1365             


Ser Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Thr  Ile Ile Met 
    1370                 1375                 1380             


Tyr Ala  Ala Val Asp Ser Val  Asn Val Asp Lys Gln  Pro Lys Tyr 
    1385                 1390                 1395             


Glu Tyr  Ser Leu Tyr Met Tyr  Ile Tyr Phe Val Val  Phe Ile Ile 
    1400                 1405                 1410             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1415                 1420                 1425             


Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Leu Gly Gly  Gln Asp Ile 
    1430                 1435                 1440             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1445                 1450                 1455             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Leu Asn 
    1460                 1465                 1470             


Lys Tyr  Gln Gly Phe Ile Phe  Asp Ile Val Thr Lys  Gln Ala Phe 
    1475                 1480                 1485             


Asp Val  Thr Ile Met Phe Leu  Ile Cys Leu Asn Met  Val Thr Met 
    1490                 1495                 1500             


Met Val  Glu Thr Asp Asp Gln  Ser Pro Glu Lys Ile  Asn Ile Leu 
    1505                 1510                 1515             


Ala Lys  Ile Asn Leu Leu Phe  Val Ala Ile Phe Thr  Gly Glu Cys 
    1520                 1525                 1530             


Ile Val  Lys Leu Ala Ala Leu  Arg His Tyr Tyr Phe  Thr Asn Ser 
    1535                 1540                 1545             


Trp Asn  Ile Phe Asp Phe Val  Val Val Ile Leu Ser  Ile Val Gly 
    1550                 1555                 1560             


Thr Val  Leu Ser Asp Ile Ile  Gln Lys Tyr Phe Phe  Ser Pro Thr 
    1565                 1570                 1575             


Leu Phe  Arg Val Ile Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg 
    1580                 1585                 1590             


Leu Ile  Arg Gly Ala Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu 
    1595                 1600                 1605             


Met Met  Ser Leu Pro Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe 
    1610                 1615                 1620             


Leu Val  Met Phe Ile Tyr Ser  Ile Phe Gly Met Ala  Asn Phe Ala 
    1625                 1630                 1635             


Tyr Val  Lys Trp Glu Ala Gly  Ile Asp Asp Met Phe  Asn Phe Gln 
    1640                 1645                 1650             


Thr Phe  Ala Asn Ser Met Leu  Cys Leu Phe Gln Ile  Thr Thr Ser 
    1655                 1660                 1665             


Ala Gly  Trp Asp Gly Leu Leu  Ser Pro Ile Leu Asn  Thr Gly Pro 
    1670                 1675                 1680             


Pro Tyr  Cys Asp Pro Thr Leu  Pro Asn Ser Asn Gly  Ser Arg Gly 
    1685                 1690                 1695             


Asp Cys  Gly Ser Pro Ala Val  Gly Ile Leu Phe Phe  Thr Thr Tyr 
    1700                 1705                 1710             


Ile Ile  Ile Ser Phe Leu Ile  Val Val Asn Met Tyr  Ile Ala Ile 
    1715                 1720                 1725             


Ile Leu  Glu Asn Phe Ser Val  Ala Thr Glu Glu Ser  Thr Glu Pro 
    1730                 1735                 1740             


Leu Ser  Glu Asp Asp Phe Asp  Met Phe Tyr Glu Ile  Trp Glu Lys 
    1745                 1750                 1755             


Phe Asp  Pro Glu Ala Thr Gln  Phe Ile Glu Tyr Ser  Val Leu Ser 
    1760                 1765                 1770             


Asp Phe  Ala Asp Ala Leu Ser  Glu Pro Leu Arg Ile  Ala Lys Pro 
    1775                 1780                 1785             


Asn Gln  Ile Ser Leu Ile Asn  Met Asp Leu Pro Met  Val Ser Gly 
    1790                 1795                 1800             


Asp Arg  Ile His Cys Met Asp  Ile Leu Phe Ala Phe  Thr Lys Arg 
    1805                 1810                 1815             


Val Leu  Gly Glu Ser Gly Glu  Met Asp Ala Leu Lys  Ile Gln Met 
    1820                 1825                 1830             


Glu Glu  Lys Phe Met Ala Ala  Asn Pro Ser Lys Ile  Ser Tyr Glu 
    1835                 1840                 1845             


Pro Ile  Thr Thr Thr Leu Arg  Arg Lys His Glu Glu  Val Ser Ala 
    1850                 1855                 1860             


Met Val  Ile Gln Arg Ala Phe  Arg Arg His Leu Leu  Gln Arg Ser 
    1865                 1870                 1875             


Leu Lys  His Ala Ser Phe Leu  Phe Arg Gln Gln Ala  Gly Ser Gly 
    1880                 1885                 1890             


Leu Ser  Glu Glu Asp Ala Pro  Glu Arg Glu Gly Leu  Ile Ala Tyr 
    1895                 1900                 1905             


Val Met  Ser Glu Asn Phe Ser  Arg Pro Leu Gly Pro  Pro Ser Ser 
    1910                 1915                 1920             


Ser Ser  Ile Ser Ser Thr Ser  Phe Pro Pro Ser Tyr  Asp Ser Val 
    1925                 1930                 1935             


Thr Arg  Ala Thr Ser Asp Asn  Leu Gln Val Arg Gly  Ser Asp Tyr 
    1940                 1945                 1950             


Ser His  Ser Glu Asp Leu Ala  Asp Phe Pro Pro Ser  Pro Asp Arg 
    1955                 1960                 1965             


Asp Arg  Glu Ser Ile Val 
    1970                 


<210>  16
<211>  2044
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav157 chimera 7

<400>  16

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala Lys Gln Lys Glu Leu 
            420                 425                 430         


Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys Glu Gln Glu Glu Ala 
        435                 440                 445             


Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr Ser Ile Arg Arg Ser 
    450                 455                 460                 


Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu Thr Ser Lys Leu Ser 
465                 470                 475                 480 


Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Lys Lys Lys Asn Gln 
                485                 490                 495     


Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp Ala Glu Lys Leu Ser 
            500                 505                 510         


Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys Ser Phe His Leu Gly 
        515                 520                 525             


Val Glu Gly His Arg Arg Ala His Glu Lys Arg Leu Ser Thr Pro Asn 
    530                 535                 540                 


Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe Ser Ala Arg Arg Ser 
545                 550                 555                 560 


Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg Gly Arg Asp Ile Gly 
                565                 570                 575     


Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile Phe Gly Asp Asn 
            580                 585                 590         


Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His Arg Pro Gln Glu Arg 
        595                 600                 605             


Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser Pro Pro Met Leu Pro 
    610                 615                 620                 


Val Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser 
625                 630                 635                 640 


Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro Asn Gly Gln Leu Leu 
                645                 650                 655     


Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys Arg Arg Cys Ser Ser 
            660                 665                 670         


Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro Asn Leu Arg Gln Arg 
        675                 680                 685             


Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu 
    690                 695                 700                 


Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Lys 
705                 710                 715                 720 


Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Cys 
                725                 730                 735     


Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
            740                 745                 750         


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met 
        755                 760                 765             


Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly Asn Leu Val Phe Thr 
    770                 775                 780                 


Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro 
785                 790                 795                 800 


Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val 
                805                 810                 815     


Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser 
            820                 825                 830         


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
        835                 840                 845             


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
    850                 855                 860                 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
865                 870                 875                 880 


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
                885                 890                 895     


Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp 
            900                 905                 910         


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
        915                 920                 925             


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys 
    930                 935                 940                 


Leu Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
945                 950                 955                 960 


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala Asp Asn Leu 
                965                 970                 975     


Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln Leu Ala Leu 
            980                 985                 990         


Ala Arg Ile Gln Arg Gly Leu Arg  Phe Val Lys Arg Thr  Thr Trp Asp 
        995                 1000                 1005             


Phe Cys  Cys Gly Leu Leu Arg  Gln Arg Pro Gln Lys  Pro Ala Ala 
    1010                 1015                 1020             


Leu Ala  Ala Gln Gly Gln Leu  Pro Ser Cys Ile Ala  Thr Pro Tyr 
    1025                 1030                 1035             


Ser Pro  Pro Pro Pro Glu Thr  Glu Lys Val Pro Pro  Thr Arg Lys 
    1040                 1045                 1050             


Glu Thr  Arg Phe Glu Glu Gly  Glu Gln Pro Gly Gln  Gly Thr Pro 
    1055                 1060                 1065             


Gly Asp  Pro Glu Pro Val Cys  Val Pro Ile Ala Val  Ala Glu Ser 
    1070                 1075                 1080             


Asp Thr  Asp Asp Gln Glu Glu  Asp Glu Glu Asn Ser  Leu Gly Thr 
    1085                 1090                 1095             


Glu Glu  Glu Ser Ser Lys Gln  Glu Ser Gln Pro Val  Ser Gly Gly 
    1100                 1105                 1110             


Pro Glu  Ala Pro Pro Asp Ser  Arg Thr Trp Ser Gln  Val Ser Ala 
    1115                 1120                 1125             


Thr Ala  Ser Ser Glu Ala Glu  Ala Ser Ala Ser Gln  Ala Asp Trp 
    1130                 1135                 1140             


Arg Gln  Gln Trp Lys Ala Glu  Pro Gln Ala Pro Gly  Cys Gly Glu 
    1145                 1150                 1155             


Thr Pro  Glu Asp Ser Cys Ser  Glu Gly Ser Thr Ala  Asp Met Thr 
    1160                 1165                 1170             


Asn Thr  Ala Glu Leu Leu Glu  Gln Ile Pro Asp Leu  Gly Gln Asp 
    1175                 1180                 1185             


Val Lys  Asp Pro Glu Asp Cys  Phe Thr Glu Gly Cys  Val Arg Arg 
    1190                 1195                 1200             


Cys Pro  Cys Cys Ala Val Asp  Thr Thr Gln Ala Pro  Gly Lys Val 
    1205                 1210                 1215             


Trp Trp  Arg Leu Arg Lys Thr  Cys Tyr His Ile Val  Glu His Ser 
    1220                 1225                 1230             


Trp Phe  Glu Thr Phe Ile Ile  Phe Met Ile Leu Leu  Ser Ser Gly 
    1235                 1240                 1245             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Leu Glu Glu Arg  Lys Thr Ile 
    1250                 1255                 1260             


Lys Val  Leu Leu Glu Tyr Ala  Asp Lys Met Phe Thr  Tyr Val Phe 
    1265                 1270                 1275             


Val Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Phe Lys Lys 
    1280                 1285                 1290             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1295                 1300                 1305             


Val Ser  Leu Val Ser Leu Val  Ala Asn Thr Leu Gly  Phe Ala Glu 
    1310                 1315                 1320             


Met Gly  Pro Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1325                 1330                 1335             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1340                 1345                 1350             


Ala Leu  Val Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1355                 1360                 1365             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1370                 1375                 1380             


Phe Ala  Gly Lys Phe Gly Arg  Cys Ile Asn Gln Thr  Glu Gly Asp 
    1385                 1390                 1395             


Leu Pro  Leu Asn Tyr Thr Ile  Val Asn Asn Lys Ser  Gln Cys Glu 
    1400                 1405                 1410             


Ser Leu  Asn Leu Thr Gly Glu  Leu Tyr Trp Thr Lys  Val Lys Val 
    1415                 1420                 1425             


Asn Phe  Asp Asn Val Gly Ala  Gly Tyr Leu Ala Leu  Leu Gln Val 
    1430                 1435                 1440             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1445                 1450                 1455             


Ser Arg  Gly Tyr Glu Glu Gln  Pro Gln Trp Glu Tyr  Asn Leu Tyr 
    1460                 1465                 1470             


Met Tyr  Ile Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1475                 1480                 1485             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1490                 1495                 1500             


Gln Lys  Lys Lys Leu Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1505                 1510                 1515             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1520                 1525                 1530             


Pro Gln  Lys Pro Ile Pro Arg  Pro Leu Asn Lys Tyr  Gln Gly Phe 
    1535                 1540                 1545             


Ile Phe  Asp Ile Val Thr Lys  Gln Ala Phe Asp Val  Thr Ile Met 
    1550                 1555                 1560             


Phe Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1565                 1570                 1575             


Asp Gln  Ser Pro Glu Lys Ile  Asn Ile Leu Ala Lys  Ile Asn Leu 
    1580                 1585                 1590             


Leu Phe  Val Ala Ile Phe Thr  Gly Glu Cys Ile Val  Lys Leu Ala 
    1595                 1600                 1605             


Ala Leu  Arg His Tyr Tyr Phe  Thr Asn Ser Trp Asn  Ile Phe Asp 
    1610                 1615                 1620             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Thr Val  Leu Ser Asp 
    1625                 1630                 1635             


Ile Ile  Gln Lys Tyr Phe Phe  Ser Pro Thr Leu Phe  Arg Val Ile 
    1640                 1645                 1650             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Arg Gly Ala 
    1655                 1660                 1665             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1670                 1675                 1680             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1685                 1690                 1695             


Tyr Ser  Ile Phe Gly Met Ala  Asn Phe Ala Tyr Val  Lys Trp Glu 
    1700                 1705                 1710             


Ala Gly  Ile Asp Asp Met Phe  Asn Phe Gln Thr Phe  Ala Asn Ser 
    1715                 1720                 1725             


Met Leu  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1730                 1735                 1740             


Leu Leu  Ser Pro Ile Leu Asn  Thr Gly Pro Pro Tyr  Cys Asp Pro 
    1745                 1750                 1755             


Thr Leu  Pro Asn Ser Asn Gly  Ser Arg Gly Asp Cys  Gly Ser Pro 
    1760                 1765                 1770             


Ala Val  Gly Ile Leu Phe Phe  Thr Thr Tyr Ile Ile  Ile Ser Phe 
    1775                 1780                 1785             


Leu Ile  Val Val Asn Met Tyr  Ile Ala Ile Ile Leu  Glu Asn Phe 
    1790                 1795                 1800             


Ser Val  Ala Thr Glu Glu Ser  Thr Glu Pro Leu Ser  Glu Asp Asp 
    1805                 1810                 1815             


Phe Asp  Met Phe Tyr Glu Ile  Trp Glu Lys Phe Asp  Pro Glu Ala 
    1820                 1825                 1830             


Thr Gln  Phe Ile Glu Tyr Ser  Val Leu Ser Asp Phe  Ala Asp Ala 
    1835                 1840                 1845             


Leu Ser  Glu Pro Leu Arg Ile  Ala Lys Pro Asn Gln  Ile Ser Leu 
    1850                 1855                 1860             


Ile Asn  Met Asp Leu Pro Met  Val Ser Gly Asp Arg  Ile His Cys 
    1865                 1870                 1875             


Met Asp  Ile Leu Phe Ala Phe  Thr Lys Arg Val Leu  Gly Glu Ser 
    1880                 1885                 1890             


Gly Glu  Met Asp Ala Leu Lys  Ile Gln Met Glu Glu  Lys Phe Met 
    1895                 1900                 1905             


Ala Ala  Asn Pro Ser Lys Ile  Ser Tyr Glu Pro Ile  Thr Thr Thr 
    1910                 1915                 1920             


Leu Arg  Arg Lys His Glu Glu  Val Ser Ala Met Val  Ile Gln Arg 
    1925                 1930                 1935             


Ala Phe  Arg Arg His Leu Leu  Gln Arg Ser Leu Lys  His Ala Ser 
    1940                 1945                 1950             


Phe Leu  Phe Arg Gln Gln Ala  Gly Ser Gly Leu Ser  Glu Glu Asp 
    1955                 1960                 1965             


Ala Pro  Glu Arg Glu Gly Leu  Ile Ala Tyr Val Met  Ser Glu Asn 
    1970                 1975                 1980             


Phe Ser  Arg Pro Leu Gly Pro  Pro Ser Ser Ser Ser  Ile Ser Ser 
    1985                 1990                 1995             


Thr Ser  Phe Pro Pro Ser Tyr  Asp Ser Val Thr Arg  Ala Thr Ser 
    2000                 2005                 2010             


Asp Asn  Leu Gln Val Arg Gly  Ser Asp Tyr Ser His  Ser Glu Asp 
    2015                 2020                 2025             


Leu Ala  Asp Phe Pro Pro Ser  Pro Asp Arg Asp Arg  Glu Ser Ile 
    2030                 2035                 2040             


Val 
    


<210>  17
<211>  2004
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav157 chimera 8

<400>  17

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr 
                405                 410                 415     


Glu Glu Lys Glu Lys Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys 
            420                 425                 430         


Glu His Glu Ala Leu Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser 
        435                 440                 445             


Ser Leu Glu Met Ser Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg 
    450                 455                 460                 


Ser Lys Arg Arg Lys Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu 
465                 470                 475                 480 


Asp Arg Leu Pro Lys Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn 
                485                 490                 495     


His Leu Ser Leu Thr Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg 
            500                 505                 510         


Ser Ser Arg Gly Ser Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser 
        515                 520                 525             


Glu Ala Asp Phe Ala Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu 
    530                 535                 540                 


Ser His His Thr Ser Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser 
545                 550                 555                 560 


Ala Gln Gly Gln Pro Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu 
                565                 570                 575     


His Gly Lys Lys Asn Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu 
            580                 585                 590         


Leu Gly Ala Gly Asp Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu 
        595                 600                 605             


Arg Pro Val Met Leu Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu 
    610                 615                 620                 


Glu Pro Gly Gly Pro Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp 
625                 630                 635                 640 


Gly Phe Glu Glu Pro Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser 
                645                 650                 655     


Val Leu Thr Ser Ala Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys 
            660                 665                 670         


Pro Pro Cys Trp Asn Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys 
        675                 680                 685             


Cys Pro Leu Trp Met Ser Ile Lys Gln Gly Val Lys Leu Val Val Met 
    690                 695                 700                 


Asp Pro Phe Thr Asp Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr 
705                 710                 715                 720 


Leu Phe Met Ala Leu Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu 
                725                 730                 735     


Met Leu Gln Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu 
            740                 745                 750         


Met Thr Phe Lys Ile Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln 
        755                 760                 765             


Gly Trp Asn Ile Phe Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu 
    770                 775                 780                 


Leu Gly Leu Ser Arg Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg 
785                 790                 795                 800 


Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr 
                805                 810                 815     


Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr 
            820                 825                 830         


Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln 
        835                 840                 845             


Leu Phe Gly Lys Asn Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu 
    850                 855                 860                 


Leu Pro Arg Trp His Met Met Asp Phe Phe His Ala Phe Leu Ile Ile 
865                 870                 875                 880 


Phe Arg Ile Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
                885                 890                 895     


Glu Val Ser Gly Gln Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met 
            900                 905                 910         


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
        915                 920                 925             


Ser Ser Phe Ser Ala Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu 
    930                 935                 940                 


Met Asn Asn Leu Gln Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg 
945                 950                 955                 960 


Phe Val Lys Arg Thr Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln 
                965                 970                 975     


Arg Pro Gln Lys Pro Ala Ala Leu Ala Ala Gln Gly Gln Leu Pro Ser 
            980                 985                 990         


Cys Ile Ala Thr Pro Tyr Ser Pro  Pro Pro Pro Glu Thr  Glu Lys Val 
        995                 1000                 1005             


Pro Pro  Thr Arg Lys Glu Thr  Arg Phe Glu Glu Gly  Glu Gln Pro 
    1010                 1015                 1020             


Gly Gln  Gly Thr Pro Gly Asp  Pro Glu Pro Val Cys  Val Pro Ile 
    1025                 1030                 1035             


Ala Val  Ala Glu Ser Asp Thr  Asp Asp Gln Glu Glu  Asp Glu Glu 
    1040                 1045                 1050             


Asn Ser  Leu Gly Thr Glu Glu  Glu Ser Ser Lys Gln  Glu Ser Gln 
    1055                 1060                 1065             


Pro Val  Ser Gly Gly Pro Glu  Ala Pro Pro Asp Ser  Arg Thr Trp 
    1070                 1075                 1080             


Ser Gln  Val Ser Ala Thr Ala  Ser Ser Glu Ala Glu  Ala Ser Ala 
    1085                 1090                 1095             


Ser Gln  Ala Asp Trp Arg Gln  Gln Trp Lys Ala Glu  Pro Gln Ala 
    1100                 1105                 1110             


Pro Gly  Cys Gly Glu Thr Pro  Glu Asp Ser Cys Ser  Glu Gly Ser 
    1115                 1120                 1125             


Thr Ala  Asp Met Thr Asn Thr  Ala Glu Leu Leu Glu  Gln Ile Pro 
    1130                 1135                 1140             


Asp Leu  Gly Gln Asp Val Lys  Asp Pro Glu Asp Cys  Phe Thr Glu 
    1145                 1150                 1155             


Gly Cys  Val Arg Arg Cys Pro  Cys Cys Ala Val Asp  Thr Thr Gln 
    1160                 1165                 1170             


Ala Pro  Gly Lys Val Trp Trp  Arg Leu Arg Lys Thr  Cys Tyr His 
    1175                 1180                 1185             


Ile Val  Glu His Ser Trp Phe  Glu Thr Phe Ile Ile  Phe Met Ile 
    1190                 1195                 1200             


Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu Asp Ile  Tyr Leu Glu 
    1205                 1210                 1215             


Glu Arg  Lys Thr Ile Lys Val  Leu Leu Glu Tyr Ala  Asp Lys Met 
    1220                 1225                 1230             


Phe Thr  Tyr Val Phe Val Leu  Glu Met Leu Leu Lys  Trp Val Ala 
    1235                 1240                 1245             


Tyr Gly  Phe Lys Lys Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp 
    1250                 1255                 1260             


Phe Leu  Ile Val Asp Val Ser  Leu Val Ser Leu Val  Ala Asn Thr 
    1265                 1270                 1275             


Leu Gly  Phe Ala Glu Met Gly  Pro Ile Lys Ser Leu  Arg Thr Leu 
    1280                 1285                 1290             


Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met 
    1295                 1300                 1305             


Arg Val  Val Val Asn Ala Leu  Val Gly Ala Ile Pro  Ser Ile Met 
    1310                 1315                 1320             


Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile 
    1325                 1330                 1335             


Met Gly  Val Asn Leu Phe Ala  Gly Lys Phe Gly Arg  Cys Ile Asn 
    1340                 1345                 1350             


Gln Thr  Glu Gly Asp Leu Pro  Leu Asn Tyr Thr Ile  Val Asn Asn 
    1355                 1360                 1365             


Lys Ser  Gln Cys Glu Ser Leu  Asn Leu Thr Gly Glu  Leu Tyr Trp 
    1370                 1375                 1380             


Thr Lys  Val Lys Val Asn Phe  Asp Asn Val Gly Ala  Gly Tyr Leu 
    1385                 1390                 1395             


Ala Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met 
    1400                 1405                 1410             


Tyr Ala  Ala Val Asp Ser Arg  Gly Tyr Glu Glu Gln  Pro Gln Trp 
    1415                 1420                 1425             


Glu Tyr  Asn Leu Tyr Met Tyr  Ile Tyr Phe Val Ile  Phe Ile Ile 
    1430                 1435                 1440             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1445                 1450                 1455             


Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Leu Gly Gly  Gln Asp Ile 
    1460                 1465                 1470             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1475                 1480                 1485             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Leu Asn 
    1490                 1495                 1500             


Lys Tyr  Gln Gly Phe Ile Phe  Asp Ile Val Thr Lys  Gln Ala Phe 
    1505                 1510                 1515             


Asp Val  Thr Ile Met Phe Leu  Ile Cys Leu Asn Met  Val Thr Met 
    1520                 1525                 1530             


Met Val  Glu Thr Asp Asp Gln  Ser Pro Glu Lys Ile  Asn Ile Leu 
    1535                 1540                 1545             


Ala Lys  Ile Asn Leu Leu Phe  Val Ala Ile Phe Thr  Gly Glu Cys 
    1550                 1555                 1560             


Ile Val  Lys Leu Ala Ala Leu  Arg His Tyr Tyr Phe  Thr Asn Ser 
    1565                 1570                 1575             


Trp Asn  Ile Phe Asp Phe Val  Val Val Ile Leu Ser  Ile Val Gly 
    1580                 1585                 1590             


Thr Val  Leu Ser Asp Ile Ile  Gln Lys Tyr Phe Phe  Ser Pro Thr 
    1595                 1600                 1605             


Leu Phe  Arg Val Ile Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg 
    1610                 1615                 1620             


Leu Ile  Arg Gly Ala Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu 
    1625                 1630                 1635             


Met Met  Ser Leu Pro Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe 
    1640                 1645                 1650             


Leu Val  Met Phe Ile Tyr Ser  Ile Phe Gly Met Ala  Asn Phe Ala 
    1655                 1660                 1665             


Tyr Val  Lys Trp Glu Ala Gly  Ile Asp Asp Met Phe  Asn Phe Gln 
    1670                 1675                 1680             


Thr Phe  Ala Asn Ser Met Leu  Cys Leu Phe Gln Ile  Thr Thr Ser 
    1685                 1690                 1695             


Ala Gly  Trp Asp Gly Leu Leu  Ser Pro Ile Leu Asn  Thr Gly Pro 
    1700                 1705                 1710             


Pro Tyr  Cys Asp Pro Thr Leu  Pro Asn Ser Asn Gly  Ser Arg Gly 
    1715                 1720                 1725             


Asp Cys  Gly Ser Pro Ala Val  Gly Ile Leu Phe Phe  Thr Thr Tyr 
    1730                 1735                 1740             


Ile Ile  Ile Ser Phe Leu Ile  Val Val Asn Met Tyr  Ile Ala Ile 
    1745                 1750                 1755             


Ile Leu  Glu Asn Phe Ser Val  Ala Thr Glu Glu Ser  Thr Glu Pro 
    1760                 1765                 1770             


Leu Ser  Glu Asp Asp Phe Asp  Met Phe Tyr Glu Ile  Trp Glu Lys 
    1775                 1780                 1785             


Phe Asp  Pro Glu Ala Thr Gln  Phe Ile Glu Tyr Ser  Val Leu Ser 
    1790                 1795                 1800             


Asp Phe  Ala Asp Ala Leu Ser  Glu Pro Leu Arg Ile  Ala Lys Pro 
    1805                 1810                 1815             


Asn Gln  Ile Ser Leu Ile Asn  Met Asp Leu Pro Met  Val Ser Gly 
    1820                 1825                 1830             


Asp Arg  Ile His Cys Met Asp  Ile Leu Phe Ala Phe  Thr Lys Arg 
    1835                 1840                 1845             


Val Leu  Gly Glu Ser Gly Glu  Met Asp Ala Leu Lys  Ile Gln Met 
    1850                 1855                 1860             


Glu Glu  Lys Phe Met Ala Ala  Asn Pro Ser Lys Ile  Ser Tyr Glu 
    1865                 1870                 1875             


Pro Ile  Thr Thr Thr Leu Arg  Arg Lys His Glu Glu  Val Ser Ala 
    1880                 1885                 1890             


Met Val  Ile Gln Arg Ala Phe  Arg Arg His Leu Leu  Gln Arg Ser 
    1895                 1900                 1905             


Leu Lys  His Ala Ser Phe Leu  Phe Arg Gln Gln Ala  Gly Ser Gly 
    1910                 1915                 1920             


Leu Ser  Glu Glu Asp Ala Pro  Glu Arg Glu Gly Leu  Ile Ala Tyr 
    1925                 1930                 1935             


Val Met  Ser Glu Asn Phe Ser  Arg Pro Leu Gly Pro  Pro Ser Ser 
    1940                 1945                 1950             


Ser Ser  Ile Ser Ser Thr Ser  Phe Pro Pro Ser Tyr  Asp Ser Val 
    1955                 1960                 1965             


Thr Arg  Ala Thr Ser Asp Asn  Leu Gln Val Arg Gly  Ser Asp Tyr 
    1970                 1975                 1980             


Ser His  Ser Glu Asp Leu Ala  Asp Phe Pro Pro Ser  Pro Asp Arg 
    1985                 1990                 1995             


Asp Arg  Glu Ser Ile Val 
    2000                 


<210>  18
<211>  1983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav157 chimera 12

<400>  18

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Val Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Arg 
            260                 265                 270         


His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn Gly Thr Asn Gly Ser 
        275                 280                 285             


Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu Asp Leu Tyr Leu Ser 
    290                 295                 300                 


Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr Ser Asp Val Leu Leu 
305                 310                 315                 320 


Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro Glu Gly Tyr Arg Cys 
                325                 330                 335     


Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr Thr Ser Phe Asp Ser 
            340                 345                 350         


Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu Met Thr Gln Asp Cys 
        355                 360                 365             


Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser Ala Gly Lys Ile Tyr 
    370                 375                 380                 


Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Val 
385                 390                 395                 400 


Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln 
                405                 410                 415     


Ala Asn Ile Glu Glu Ala Lys Gln Lys Glu Leu Glu Phe Gln Gln Met 
            420                 425                 430         


Leu Asp Arg Leu Lys Lys Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala 
        435                 440                 445             


Ala Ala Ala Glu Tyr Thr Ser Ile Arg Arg Ser Arg Ile Met Gly Leu 
    450                 455                 460                 


Ser Glu Ser Ser Ser Glu Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys 
465                 470                 475                 480 


Glu Arg Arg Asn Arg Arg Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser 
                485                 490                 495     


Gly Glu Glu Lys Gly Asp Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu 
            500                 505                 510         


Asp Ser Ile Arg Arg Lys Ser Phe His Leu Gly Val Glu Gly His Arg 
        515                 520                 525             


Arg Ala His Glu Lys Arg Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser 
    530                 535                 540                 


Ile Arg Gly Ser Leu Phe Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu 
545                 550                 555                 560 


Phe Ser Phe Lys Gly Arg Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe 
                565                 570                 575     


Ala Asp Asp Glu His Ser Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly 
            580                 585                 590         


Ser Leu Phe Val Pro His Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile 
        595                 600                 605             


Ser Gln Ala Ser Arg Ser Pro Pro Met Leu Pro Val Asn Gly Lys Met 
    610                 615                 620                 


His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu Val Asp Gly Arg 
625                 630                 635                 640 


Ser Ala Leu Met Leu Pro Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr 
                645                 650                 655     


Asn Gln Ile His Lys Lys Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu 
            660                 665                 670         


Asp Met Leu Asn Asp Pro Asn Leu Arg Gln Arg Ala Met Ser Arg Ala 
        675                 680                 685             


Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys 
    690                 695                 700                 


Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Lys Phe Leu Ile Trp Asn 
705                 710                 715                 720 


Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val 
                725                 730                 735     


Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn 
            740                 745                 750         


Thr Leu Phe Met Ala Met Glu His His Pro Met Thr Glu Glu Phe Lys 
        755                 760                 765             


Asn Val Leu Ala Ile Gly Asn Leu Val Phe Thr Gly Ile Phe Ala Ala 
    770                 775                 780                 


Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln 
785                 790                 795                 800 


Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val Thr Leu Ser Leu Val 
                805                 810                 815     


Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val Leu Arg Ser Phe 
            820                 825                 830         


Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn 
        835                 840                 845             


Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu 
    850                 855                 860                 


Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met 
865                 870                 875                 880 


Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp 
                885                 890                 895     


Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe 
            900                 905                 910         


Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp 
        915                 920                 925             


Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu Ile Val Tyr Met 
    930                 935                 940                 


Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala 
945                 950                 955                 960 


Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu 
                965                 970                 975     


Asp Pro Asp Ala Asn Asn Leu Gln Ile Ala Val Thr Arg Ile Lys Lys 
            980                 985                 990         


Gly Ile Asn Tyr Val Lys Gln Thr  Leu Arg Glu Phe Ile  Leu Lys Ala 
        995                 1000                 1005             


Phe Ser  Lys Lys Pro Lys Ile  Ser Arg Glu Ile Arg  Gln Ala Glu 
    1010                 1015                 1020             


Asp Leu  Asn Thr Lys Lys Glu  Asn Tyr Ile Ser Asn  His Thr Leu 
    1025                 1030                 1035             


Ala Glu  Met Ser Lys Gly His  Asn Phe Leu Lys Glu  Lys Asp Lys 
    1040                 1045                 1050             


Ile Ser  Gly Phe Gly Ser Ser  Val Asp Lys His Leu  Met Glu Asp 
    1055                 1060                 1065             


Ser Asp  Gly Gln Ser Phe Ile  His Asn Pro Ser Leu  Thr Val Thr 
    1070                 1075                 1080             


Val Pro  Ile Ala Pro Gly Glu  Ser Asp Leu Glu Asn  Met Asn Ala 
    1085                 1090                 1095             


Glu Glu  Leu Ser Ser Asp Ser  Asp Ser Glu Tyr Ser  Lys Val Arg 
    1100                 1105                 1110             


Leu Asn  Arg Ser Ser Ser Ser  Glu Cys Ser Thr Val  Asp Asn Pro 
    1115                 1120                 1125             


Leu Pro  Gly Glu Gly Glu Glu  Ala Glu Ala Glu Pro  Met Asn Ser 
    1130                 1135                 1140             


Asp Glu  Pro Glu Ala Cys Phe  Thr Asp Gly Cys Val  Arg Arg Phe 
    1145                 1150                 1155             


Ser Cys  Cys Gln Val Asn Ile  Glu Ser Gly Lys Gly  Lys Ile Trp 
    1160                 1165                 1170             


Trp Asn  Ile Arg Lys Thr Cys  Tyr Lys Ile Val Glu  His Ser Trp 
    1175                 1180                 1185             


Phe Glu  Ser Phe Ile Val Leu  Met Ile Leu Leu Ser  Ser Gly Ala 
    1190                 1195                 1200             


Leu Ala  Phe Glu Asp Ile Tyr  Ile Glu Arg Lys Lys  Thr Ile Lys 
    1205                 1210                 1215             


Ile Ile  Leu Glu Tyr Ala Asp  Lys Ile Phe Thr Tyr  Ile Phe Ile 
    1220                 1225                 1230             


Leu Glu  Met Leu Leu Lys Trp  Ile Ala Tyr Gly Tyr  Lys Thr Tyr 
    1235                 1240                 1245             


Phe Thr  Asn Ala Trp Cys Trp  Leu Asp Phe Leu Ile  Val Asp Val 
    1250                 1255                 1260             


Ser Leu  Val Thr Leu Val Ala  Asn Thr Leu Gly Tyr  Ser Asp Leu 
    1265                 1270                 1275             


Gly Pro  Ile Lys Ser Leu Arg  Thr Leu Arg Ala Leu  Arg Pro Leu 
    1280                 1285                 1290             


Arg Ala  Leu Ser Arg Phe Glu  Gly Met Arg Val Val  Val Asn Ala 
    1295                 1300                 1305             


Leu Ile  Gly Ala Ile Pro Ser  Ile Met Asn Val Leu  Leu Val Cys 
    1310                 1315                 1320             


Leu Ile  Phe Trp Leu Ile Phe  Ser Ile Met Gly Val  Asn Leu Phe 
    1325                 1330                 1335             


Ala Gly  Lys Phe Tyr Glu Cys  Ile Asn Thr Thr Asp  Gly Ser Arg 
    1340                 1345                 1350             


Phe Pro  Ala Ser Gln Val Pro  Asn Arg Ser Glu Cys  Phe Ala Leu 
    1355                 1360                 1365             


Met Asn  Val Ser Gln Asn Val  Arg Trp Lys Asn Leu  Lys Val Asn 
    1370                 1375                 1380             


Phe Asp  Asn Val Gly Leu Gly  Tyr Leu Ser Leu Leu  Gln Val Ala 
    1385                 1390                 1395             


Thr Phe  Lys Gly Trp Thr Ile  Ile Met Tyr Ala Ala  Val Asp Ser 
    1400                 1405                 1410             


Val Asn  Val Asp Lys Gln Pro  Lys Tyr Glu Tyr Ser  Leu Tyr Met 
    1415                 1420                 1425             


Tyr Ile  Tyr Phe Val Val Phe  Ile Ile Phe Gly Ser  Phe Phe Thr 
    1430                 1435                 1440             


Leu Asn  Leu Phe Ile Gly Val  Ile Ile Asp Asn Phe  Asn Gln Gln 
    1445                 1450                 1455             


Lys Lys  Lys Leu Gly Gly Gln  Asp Ile Phe Met Thr  Glu Glu Gln 
    1460                 1465                 1470             


Lys Lys  Tyr Tyr Asn Ala Met  Lys Lys Leu Gly Ser  Lys Lys Pro 
    1475                 1480                 1485             


Gln Lys  Pro Ile Pro Arg Pro  Gly Asn Lys Ile Gln  Gly Cys Ile 
    1490                 1495                 1500             


Phe Asp  Leu Val Thr Asn Gln  Ala Phe Asp Ile Ser  Ile Met Val 
    1505                 1510                 1515             


Leu Ile  Cys Leu Asn Met Val  Thr Met Met Val Glu  Lys Glu Gly 
    1520                 1525                 1530             


Gln Ser  Gln His Met Thr Glu  Val Leu Tyr Trp Ile  Asn Val Val 
    1535                 1540                 1545             


Phe Ile  Ile Leu Phe Thr Gly  Glu Cys Val Leu Lys  Leu Ile Ser 
    1550                 1555                 1560             


Leu Arg  His Tyr Tyr Phe Thr  Val Gly Trp Asn Ile  Phe Asp Phe 
    1565                 1570                 1575             


Val Val  Val Ile Ile Ser Ile  Val Gly Met Phe Leu  Ala Asp Leu 
    1580                 1585                 1590             


Ile Glu  Thr Tyr Phe Val Ser  Pro Thr Leu Phe Arg  Val Ile Arg 
    1595                 1600                 1605             


Leu Ala  Arg Ile Gly Arg Ile  Leu Arg Leu Val Lys  Gly Ala Lys 
    1610                 1615                 1620             


Gly Ile  Arg Thr Leu Leu Phe  Ala Leu Met Met Ser  Leu Pro Ala 
    1625                 1630                 1635             


Leu Phe  Asn Ile Gly Leu Leu  Leu Phe Leu Val Met  Phe Ile Tyr 
    1640                 1645                 1650             


Ala Ile  Phe Gly Met Ser Asn  Phe Ala Tyr Val Lys  Lys Glu Asp 
    1655                 1660                 1665             


Gly Ile  Asn Asp Met Phe Asn  Phe Glu Thr Phe Gly  Asn Ser Met 
    1670                 1675                 1680             


Ile Cys  Leu Phe Gln Ile Thr  Thr Ser Ala Gly Trp  Asp Gly Leu 
    1685                 1690                 1695             


Leu Ala  Pro Ile Leu Asn Ser  Lys Pro Pro Asp Cys  Asp Pro Lys 
    1700                 1705                 1710             


Lys Val  His Pro Gly Ser Ser  Val Glu Gly Asp Cys  Gly Asn Pro 
    1715                 1720                 1725             


Ser Val  Gly Ile Phe Tyr Phe  Val Ser Tyr Ile Ile  Ile Ser Phe 
    1730                 1735                 1740             


Leu Val  Val Val Asn Met Tyr  Ile Ala Val Ile Leu  Glu Asn Phe 
    1745                 1750                 1755             


Ser Val  Ala Thr Glu Glu Ser  Thr Glu Pro Leu Ser  Glu Asp Asp 
    1760                 1765                 1770             


Phe Glu  Met Phe Tyr Glu Val  Trp Glu Lys Phe Asp  Pro Asp Ala 
    1775                 1780                 1785             


Thr Gln  Phe Ile Glu Phe Ser  Lys Leu Ser Asp Phe  Ala Ala Ala 
    1790                 1795                 1800             


Leu Asp  Pro Pro Leu Leu Ile  Ala Lys Pro Asn Lys  Val Gln Leu 
    1805                 1810                 1815             


Ile Ala  Met Asp Leu Pro Met  Val Ser Gly Asp Arg  Ile His Cys 
    1820                 1825                 1830             


Leu Asp  Ile Leu Phe Ala Phe  Thr Lys Arg Val Leu  Gly Glu Ser 
    1835                 1840                 1845             


Gly Glu  Met Asp Ser Leu Arg  Ser Gln Met Glu Glu  Arg Phe Met 
    1850                 1855                 1860             


Ser Ala  Asn Pro Ser Lys Val  Ser Tyr Glu Pro Ile  Thr Thr Thr 
    1865                 1870                 1875             


Leu Lys  Arg Lys Gln Glu Asp  Val Ser Ala Thr Val  Ile Gln Arg 
    1880                 1885                 1890             


Ala Tyr  Arg Arg Tyr Arg Leu  Arg Gln Asn Val Lys  Asn Ile Ser 
    1895                 1900                 1905             


Ser Ile  Tyr Ile Lys Asp Gly  Asp Arg Asp Asp Asp  Leu Leu Asn 
    1910                 1915                 1920             


Lys Lys  Asp Met Ala Phe Asp  Asn Val Asn Glu Asn  Ser Ser Pro 
    1925                 1930                 1935             


Glu Lys  Thr Asp Ala Thr Ser  Ser Thr Thr Ser Pro  Pro Ser Tyr 
    1940                 1945                 1950             


Asp Ser  Val Thr Lys Pro Asp  Lys Glu Lys Tyr Glu  Gln Asp Arg 
    1955                 1960                 1965             


Thr Glu  Lys Glu Asp Lys Gly  Lys Asp Ser Lys Glu  Ser Lys Lys 
    1970                 1975                 1980             


<210>  19
<211>  2012
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav157 chimera 14

<400>  19

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Ile Phe Met Thr Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu 
        195                 200                 205             


Phe Val Asn Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Ile Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Lys His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn 
        275                 280                 285             


Glu Thr Leu Glu Ser Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe 
    290                 295                 300                 


Arg Lys Tyr Phe Tyr Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys 
305                 310                 315                 320 


Gly Phe Ser Thr Asp Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val 
                325                 330                 335     


Lys Ile Gly Arg Asn Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
            340                 345                 350         


Ser Trp Ala Phe Leu Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp 
        355                 360                 365             


Glu Asn Leu Tyr Gln Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
    370                 375                 380                 


Ile Phe Phe Val Val Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
385                 390                 395                 400 


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
                405                 410                 415     


Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys Arg Phe Gln Glu Ala Met 
            420                 425                 430         


Glu Met Leu Lys Lys Glu His Glu Ala Leu Thr Ile Arg Gly Val Asp 
        435                 440                 445             


Thr Val Ser Arg Ser Ser Leu Glu Met Ser Pro Leu Ala Pro Val Asn 
    450                 455                 460                 


Ser His Glu Arg Arg Ser Lys Arg Arg Lys Arg Met Ser Ser Gly Thr 
465                 470                 475                 480 


Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys Ser Asp Ser Glu Asp Gly 
                485                 490                 495     


Pro Arg Ala Met Asn His Leu Ser Leu Thr Arg Gly Leu Ser Arg Thr 
            500                 505                 510         


Ser Met Lys Pro Arg Ser Ser Arg Gly Ser Ile Phe Thr Phe Arg Arg 
        515                 520                 525             


Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala Asp Asp Glu Asn Ser Thr 
    530                 535                 540                 


Ala Gly Glu Ser Glu Ser His His Thr Ser Leu Leu Val Pro Trp Pro 
545                 550                 555                 560 


Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro Ser Pro Gly Thr Ser Ala 
                565                 570                 575     


Pro Gly His Ala Leu His Gly Lys Lys Asn Ser Thr Val Asp Cys Asn 
            580                 585                 590         


Gly Val Val Ser Leu Leu Gly Ala Gly Asp Pro Glu Ala Thr Ser Pro 
        595                 600                 605             


Gly Ser His Leu Leu Arg Pro Val Met Leu Glu His Pro Pro Asp Thr 
    610                 615                 620                 


Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro Gln Met Leu Thr Ser Gln 
625                 630                 635                 640 


Ala Pro Cys Val Asp Gly Phe Glu Glu Pro Gly Ala Arg Gln Arg Ala 
                645                 650                 655     


Leu Ser Ala Val Ser Val Leu Thr Ser Ala Leu Glu Glu Leu Glu Glu 
            660                 665                 670         


Ser Arg His Lys Cys Pro Pro Cys Trp Asn Arg Leu Ala Gln Arg Tyr 
        675                 680                 685             


Leu Ile Trp Glu Cys Cys Pro Leu Trp Met Ser Ile Lys Gln Gly Val 
    690                 695                 700                 


Lys Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
705                 710                 715                 720 


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met Thr 
                725                 730                 735     


Glu Glu Phe Lys Asn Val Leu Ala Ile Gly Asn Leu Val Phe Thr Gly 
            740                 745                 750         


Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr 
        755                 760                 765             


Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe Asp Ser Leu Ile Val Thr 
    770                 775                 780                 


Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val 
785                 790                 795                 800 


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
                805                 810                 815     


Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
            820                 825                 830         


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
        835                 840                 845             


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
    850                 855                 860                 


Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp Phe 
865                 870                 875                 880 


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
                885                 890                 895     


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu 
            900                 905                 910         


Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
        915                 920                 925             


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala Asp Asn Leu Thr 
    930                 935                 940                 


Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln Leu Ala Leu Ala 
945                 950                 955                 960 


Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr Thr Trp Asp Phe 
                965                 970                 975     


Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro Ala Ala Leu Ala 
            980                 985                 990         


Ala Gln Gly Gln Leu Pro Ser Cys  Ile Ala Thr Pro Tyr  Ser Pro Pro 
        995                 1000                 1005             


Pro Pro  Glu Thr Glu Lys Val  Pro Pro Thr Arg Lys  Glu Thr Arg 
    1010                 1015                 1020             


Phe Glu  Glu Gly Glu Gln Pro  Gly Gln Gly Thr Pro  Gly Asp Pro 
    1025                 1030                 1035             


Glu Pro  Val Cys Val Pro Ile  Ala Val Ala Glu Ser  Asp Thr Asp 
    1040                 1045                 1050             


Asp Gln  Glu Glu Asp Glu Glu  Asn Ser Leu Gly Thr  Glu Glu Glu 
    1055                 1060                 1065             


Ser Ser  Lys Gln Glu Ser Gln  Pro Val Ser Gly Gly  Pro Glu Ala 
    1070                 1075                 1080             


Pro Pro  Asp Ser Arg Thr Trp  Ser Gln Val Ser Ala  Thr Ala Ser 
    1085                 1090                 1095             


Ser Glu  Ala Glu Ala Ser Ala  Ser Gln Ala Asp Trp  Arg Gln Gln 
    1100                 1105                 1110             


Trp Lys  Ala Glu Pro Gln Ala  Pro Gly Cys Gly Glu  Thr Pro Glu 
    1115                 1120                 1125             


Asp Ser  Cys Ser Glu Gly Ser  Thr Ala Asp Met Thr  Asn Thr Ala 
    1130                 1135                 1140             


Glu Leu  Leu Glu Gln Ile Pro  Asp Leu Gly Gln Asp  Val Lys Asp 
    1145                 1150                 1155             


Pro Glu  Asp Cys Phe Thr Glu  Gly Cys Val Arg Arg  Cys Pro Cys 
    1160                 1165                 1170             


Cys Ala  Val Asp Thr Thr Gln  Ala Pro Gly Lys Val  Trp Trp Arg 
    1175                 1180                 1185             


Leu Arg  Lys Thr Cys Tyr His  Ile Val Glu His Ser  Trp Phe Glu 
    1190                 1195                 1200             


Ser Phe  Ile Val Leu Met Ile  Leu Leu Ser Ser Gly  Ala Leu Ala 
    1205                 1210                 1215             


Phe Glu  Asp Ile Tyr Ile Glu  Arg Lys Lys Thr Ile  Lys Ile Ile 
    1220                 1225                 1230             


Leu Glu  Tyr Ala Asp Lys Ile  Phe Thr Tyr Ile Phe  Ile Leu Glu 
    1235                 1240                 1245             


Met Leu  Leu Lys Trp Ile Ala  Tyr Gly Tyr Lys Lys  Tyr Phe Thr 
    1250                 1255                 1260             


Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile Val Asp  Val Ser Leu 
    1265                 1270                 1275             


Val Thr  Leu Val Ala Asn Thr  Leu Gly Tyr Ser Asp  Leu Gly Pro 
    1280                 1285                 1290             


Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu Arg Pro  Leu Arg Ala 
    1295                 1300                 1305             


Leu Ser  Arg Phe Glu Gly Met  Arg Val Val Val Asn  Ala Leu Val 
    1310                 1315                 1320             


Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu Leu Val  Cys Leu Ile 
    1325                 1330                 1335             


Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val Asn Leu  Phe Ala Gly 
    1340                 1345                 1350             


Lys Phe  Tyr Glu Cys Ile Asn  Thr Thr Asp Gly Ser  Arg Phe Pro 
    1355                 1360                 1365             


Ala Ser  Gln Val Pro Asn Arg  Ser Glu Cys Phe Ala  Leu Met Asn 
    1370                 1375                 1380             


Val Ser  Gln Asn Val Arg Trp  Lys Asn Leu Lys Val  Asn Phe Asp 
    1385                 1390                 1395             


Asn Val  Gly Leu Gly Tyr Leu  Ser Leu Leu Gln Val  Ala Thr Phe 
    1400                 1405                 1410             


Lys Gly  Trp Thr Ile Ile Met  Tyr Ala Ala Val Asp  Ser Val Asn 
    1415                 1420                 1425             


Val Asp  Lys Gln Pro Lys Tyr  Glu Tyr Ser Leu Tyr  Met Tyr Ile 
    1430                 1435                 1440             


Tyr Phe  Val Val Phe Ile Ile  Phe Gly Ser Phe Phe  Thr Leu Asn 
    1445                 1450                 1455             


Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe Asn Gln  Gln Lys Lys 
    1460                 1465                 1470             


Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr Glu Glu  Gln Lys Lys 
    1475                 1480                 1485             


Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser Lys Lys  Pro Gln Lys 
    1490                 1495                 1500             


Pro Ile  Pro Arg Pro Leu Asn  Lys Tyr Gln Gly Phe  Ile Phe Asp 
    1505                 1510                 1515             


Leu Val  Thr Asn Gln Ala Phe  Asp Ile Ser Ile Met  Val Leu Ile 
    1520                 1525                 1530             


Cys Leu  Asn Met Val Thr Met  Met Val Glu Lys Glu  Gly Gln Ser 
    1535                 1540                 1545             


Gln His  Met Thr Glu Val Leu  Tyr Trp Ile Asn Val  Val Phe Ile 
    1550                 1555                 1560             


Ile Leu  Phe Thr Gly Glu Cys  Val Leu Lys Leu Ile  Ser Leu Arg 
    1565                 1570                 1575             


His Tyr  Tyr Phe Thr Val Gly  Trp Asn Ile Phe Asp  Phe Val Val 
    1580                 1585                 1590             


Val Ile  Ile Ser Ile Val Gly  Met Phe Leu Ala Asp  Leu Ile Glu 
    1595                 1600                 1605             


Thr Tyr  Phe Val Ser Pro Thr  Leu Phe Arg Val Ile  Arg Leu Ala 
    1610                 1615                 1620             


Arg Ile  Gly Arg Ile Leu Arg  Leu Val Lys Gly Ala  Lys Gly Ile 
    1625                 1630                 1635             


Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser Leu Pro  Ala Leu Phe 
    1640                 1645                 1650             


Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met Phe Ile  Tyr Ala Ile 
    1655                 1660                 1665             


Phe Gly  Met Ser Asn Phe Ala  Tyr Val Lys Lys Glu  Asp Gly Ile 
    1670                 1675                 1680             


Asn Asp  Met Phe Asn Phe Glu  Thr Phe Gly Asn Ser  Met Ile Cys 
    1685                 1690                 1695             


Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp Asp Gly  Leu Leu Ala 
    1700                 1705                 1710             


Pro Ile  Leu Asn Ser Lys Pro  Pro Asp Cys Asp Pro  Lys Lys Val 
    1715                 1720                 1725             


His Pro  Gly Ser Ser Val Glu  Gly Asp Cys Gly Asn  Pro Ser Val 
    1730                 1735                 1740             


Gly Ile  Phe Tyr Phe Val Ser  Tyr Ile Ile Ile Ser  Phe Leu Val 
    1745                 1750                 1755             


Val Val  Asn Met Tyr Ile Ala  Val Ile Leu Glu Asn  Phe Ser Val 
    1760                 1765                 1770             


Ala Thr  Glu Glu Ser Thr Glu  Pro Leu Ser Glu Asp  Asp Phe Asp 
    1775                 1780                 1785             


Met Phe  Tyr Glu Ile Trp Glu  Lys Phe Asp Pro Glu  Ala Thr Gln 
    1790                 1795                 1800             


Phe Ile  Glu Tyr Ser Val Leu  Ser Asp Phe Ala Asp  Ala Leu Ser 
    1805                 1810                 1815             


Glu Pro  Leu Arg Ile Ala Lys  Pro Asn Gln Ile Ser  Leu Ile Asn 
    1820                 1825                 1830             


Met Asp  Leu Pro Met Val Ser  Gly Asp Arg Ile His  Cys Met Asp 
    1835                 1840                 1845             


Ile Leu  Phe Ala Phe Thr Lys  Arg Val Leu Gly Glu  Ser Gly Glu 
    1850                 1855                 1860             


Met Asp  Ala Leu Lys Ile Gln  Met Glu Glu Lys Phe  Met Ala Ala 
    1865                 1870                 1875             


Asn Pro  Ser Lys Ile Ser Tyr  Glu Pro Ile Thr Thr  Thr Leu Arg 
    1880                 1885                 1890             


Arg Lys  His Glu Glu Val Ser  Ala Met Val Ile Gln  Arg Ala Phe 
    1895                 1900                 1905             


Arg Arg  His Leu Leu Gln Arg  Ser Leu Lys His Ala  Ser Phe Leu 
    1910                 1915                 1920             


Phe Arg  Gln Gln Ala Gly Ser  Gly Leu Ser Glu Glu  Asp Ala Pro 
    1925                 1930                 1935             


Glu Arg  Glu Gly Leu Ile Ala  Tyr Val Met Ser Glu  Asn Phe Ser 
    1940                 1945                 1950             


Arg Pro  Leu Gly Pro Pro Ser  Ser Ser Ser Ile Ser  Ser Thr Ser 
    1955                 1960                 1965             


Phe Pro  Pro Ser Tyr Asp Ser  Val Thr Arg Ala Thr  Ser Asp Asn 
    1970                 1975                 1980             


Leu Gln  Val Arg Gly Ser Asp  Tyr Ser His Ser Glu  Asp Leu Ala 
    1985                 1990                 1995             


Asp Phe  Pro Pro Ser Pro Asp  Arg Asp Arg Glu Ser  Ile Val 
    2000                 2005                 2010         


<210>  20
<211>  2729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav157 chimera 14-beta1-beta2-beta3 viral P2A

<400>  20

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Ile Phe Met Thr Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu 
        195                 200                 205             


Phe Val Asn Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Ile Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Lys His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn 
        275                 280                 285             


Glu Thr Leu Glu Ser Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe 
    290                 295                 300                 


Arg Lys Tyr Phe Tyr Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys 
305                 310                 315                 320 


Gly Phe Ser Thr Asp Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val 
                325                 330                 335     


Lys Ile Gly Arg Asn Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
            340                 345                 350         


Ser Trp Ala Phe Leu Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp 
        355                 360                 365             


Glu Asn Leu Tyr Gln Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
    370                 375                 380                 


Ile Phe Phe Val Val Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
385                 390                 395                 400 


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
                405                 410                 415     


Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys Arg Phe Gln Glu Ala Met 
            420                 425                 430         


Glu Met Leu Lys Lys Glu His Glu Ala Leu Thr Ile Arg Gly Val Asp 
        435                 440                 445             


Thr Val Ser Arg Ser Ser Leu Glu Met Ser Pro Leu Ala Pro Val Asn 
    450                 455                 460                 


Ser His Glu Arg Arg Ser Lys Arg Arg Lys Arg Met Ser Ser Gly Thr 
465                 470                 475                 480 


Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys Ser Asp Ser Glu Asp Gly 
                485                 490                 495     


Pro Arg Ala Met Asn His Leu Ser Leu Thr Arg Gly Leu Ser Arg Thr 
            500                 505                 510         


Ser Met Lys Pro Arg Ser Ser Arg Gly Ser Ile Phe Thr Phe Arg Arg 
        515                 520                 525             


Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala Asp Asp Glu Asn Ser Thr 
    530                 535                 540                 


Ala Gly Glu Ser Glu Ser His His Thr Ser Leu Leu Val Pro Trp Pro 
545                 550                 555                 560 


Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro Ser Pro Gly Thr Ser Ala 
                565                 570                 575     


Pro Gly His Ala Leu His Gly Lys Lys Asn Ser Thr Val Asp Cys Asn 
            580                 585                 590         


Gly Val Val Ser Leu Leu Gly Ala Gly Asp Pro Glu Ala Thr Ser Pro 
        595                 600                 605             


Gly Ser His Leu Leu Arg Pro Val Met Leu Glu His Pro Pro Asp Thr 
    610                 615                 620                 


Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro Gln Met Leu Thr Ser Gln 
625                 630                 635                 640 


Ala Pro Cys Val Asp Gly Phe Glu Glu Pro Gly Ala Arg Gln Arg Ala 
                645                 650                 655     


Leu Ser Ala Val Ser Val Leu Thr Ser Ala Leu Glu Glu Leu Glu Glu 
            660                 665                 670         


Ser Arg His Lys Cys Pro Pro Cys Trp Asn Arg Leu Ala Gln Arg Tyr 
        675                 680                 685             


Leu Ile Trp Glu Cys Cys Pro Leu Trp Met Ser Ile Lys Gln Gly Val 
    690                 695                 700                 


Lys Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
705                 710                 715                 720 


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met Thr 
                725                 730                 735     


Glu Glu Phe Lys Asn Val Leu Ala Ile Gly Asn Leu Val Phe Thr Gly 
            740                 745                 750         


Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr 
        755                 760                 765             


Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe Asp Ser Leu Ile Val Thr 
    770                 775                 780                 


Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val 
785                 790                 795                 800 


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
                805                 810                 815     


Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
            820                 825                 830         


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
        835                 840                 845             


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
    850                 855                 860                 


Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp Phe 
865                 870                 875                 880 


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
                885                 890                 895     


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu 
            900                 905                 910         


Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
        915                 920                 925             


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala Asp Asn Leu Thr 
    930                 935                 940                 


Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln Leu Ala Leu Ala 
945                 950                 955                 960 


Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr Thr Trp Asp Phe 
                965                 970                 975     


Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro Ala Ala Leu Ala 
            980                 985                 990         


Ala Gln Gly Gln Leu Pro Ser Cys  Ile Ala Thr Pro Tyr  Ser Pro Pro 
        995                 1000                 1005             


Pro Pro  Glu Thr Glu Lys Val  Pro Pro Thr Arg Lys  Glu Thr Arg 
    1010                 1015                 1020             


Phe Glu  Glu Gly Glu Gln Pro  Gly Gln Gly Thr Pro  Gly Asp Pro 
    1025                 1030                 1035             


Glu Pro  Val Cys Val Pro Ile  Ala Val Ala Glu Ser  Asp Thr Asp 
    1040                 1045                 1050             


Asp Gln  Glu Glu Asp Glu Glu  Asn Ser Leu Gly Thr  Glu Glu Glu 
    1055                 1060                 1065             


Ser Ser  Lys Gln Glu Ser Gln  Pro Val Ser Gly Gly  Pro Glu Ala 
    1070                 1075                 1080             


Pro Pro  Asp Ser Arg Thr Trp  Ser Gln Val Ser Ala  Thr Ala Ser 
    1085                 1090                 1095             


Ser Glu  Ala Glu Ala Ser Ala  Ser Gln Ala Asp Trp  Arg Gln Gln 
    1100                 1105                 1110             


Trp Lys  Ala Glu Pro Gln Ala  Pro Gly Cys Gly Glu  Thr Pro Glu 
    1115                 1120                 1125             


Asp Ser  Cys Ser Glu Gly Ser  Thr Ala Asp Met Thr  Asn Thr Ala 
    1130                 1135                 1140             


Glu Leu  Leu Glu Gln Ile Pro  Asp Leu Gly Gln Asp  Val Lys Asp 
    1145                 1150                 1155             


Pro Glu  Asp Cys Phe Thr Glu  Gly Cys Val Arg Arg  Cys Pro Cys 
    1160                 1165                 1170             


Cys Ala  Val Asp Thr Thr Gln  Ala Pro Gly Lys Val  Trp Trp Arg 
    1175                 1180                 1185             


Leu Arg  Lys Thr Cys Tyr His  Ile Val Glu His Ser  Trp Phe Glu 
    1190                 1195                 1200             


Ser Phe  Ile Val Leu Met Ile  Leu Leu Ser Ser Gly  Ala Leu Ala 
    1205                 1210                 1215             


Phe Glu  Asp Ile Tyr Ile Glu  Arg Lys Lys Thr Ile  Lys Ile Ile 
    1220                 1225                 1230             


Leu Glu  Tyr Ala Asp Lys Ile  Phe Thr Tyr Ile Phe  Ile Leu Glu 
    1235                 1240                 1245             


Met Leu  Leu Lys Trp Ile Ala  Tyr Gly Tyr Lys Lys  Tyr Phe Thr 
    1250                 1255                 1260             


Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile Val Asp  Val Ser Leu 
    1265                 1270                 1275             


Val Thr  Leu Val Ala Asn Thr  Leu Gly Tyr Ser Asp  Leu Gly Pro 
    1280                 1285                 1290             


Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu Arg Pro  Leu Arg Ala 
    1295                 1300                 1305             


Leu Ser  Arg Phe Glu Gly Met  Arg Val Val Val Asn  Ala Leu Val 
    1310                 1315                 1320             


Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu Leu Val  Cys Leu Ile 
    1325                 1330                 1335             


Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val Asn Leu  Phe Ala Gly 
    1340                 1345                 1350             


Lys Phe  Tyr Glu Cys Ile Asn  Thr Thr Asp Gly Ser  Arg Phe Pro 
    1355                 1360                 1365             


Ala Ser  Gln Val Pro Asn Arg  Ser Glu Cys Phe Ala  Leu Met Asn 
    1370                 1375                 1380             


Val Ser  Gln Asn Val Arg Trp  Lys Asn Leu Lys Val  Asn Phe Asp 
    1385                 1390                 1395             


Asn Val  Gly Leu Gly Tyr Leu  Ser Leu Leu Gln Val  Ala Thr Phe 
    1400                 1405                 1410             


Lys Gly  Trp Thr Ile Ile Met  Tyr Ala Ala Val Asp  Ser Val Asn 
    1415                 1420                 1425             


Val Asp  Lys Gln Pro Lys Tyr  Glu Tyr Ser Leu Tyr  Met Tyr Ile 
    1430                 1435                 1440             


Tyr Phe  Val Val Phe Ile Ile  Phe Gly Ser Phe Phe  Thr Leu Asn 
    1445                 1450                 1455             


Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe Asn Gln  Gln Lys Lys 
    1460                 1465                 1470             


Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr Glu Glu  Gln Lys Lys 
    1475                 1480                 1485             


Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser Lys Lys  Pro Gln Lys 
    1490                 1495                 1500             


Pro Ile  Pro Arg Pro Leu Asn  Lys Tyr Gln Gly Phe  Ile Phe Asp 
    1505                 1510                 1515             


Leu Val  Thr Asn Gln Ala Phe  Asp Ile Ser Ile Met  Val Leu Ile 
    1520                 1525                 1530             


Cys Leu  Asn Met Val Thr Met  Met Val Glu Lys Glu  Gly Gln Ser 
    1535                 1540                 1545             


Gln His  Met Thr Glu Val Leu  Tyr Trp Ile Asn Val  Val Phe Ile 
    1550                 1555                 1560             


Ile Leu  Phe Thr Gly Glu Cys  Val Leu Lys Leu Ile  Ser Leu Arg 
    1565                 1570                 1575             


His Tyr  Tyr Phe Thr Val Gly  Trp Asn Ile Phe Asp  Phe Val Val 
    1580                 1585                 1590             


Val Ile  Ile Ser Ile Val Gly  Met Phe Leu Ala Asp  Leu Ile Glu 
    1595                 1600                 1605             


Thr Tyr  Phe Val Ser Pro Thr  Leu Phe Arg Val Ile  Arg Leu Ala 
    1610                 1615                 1620             


Arg Ile  Gly Arg Ile Leu Arg  Leu Val Lys Gly Ala  Lys Gly Ile 
    1625                 1630                 1635             


Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser Leu Pro  Ala Leu Phe 
    1640                 1645                 1650             


Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met Phe Ile  Tyr Ala Ile 
    1655                 1660                 1665             


Phe Gly  Met Ser Asn Phe Ala  Tyr Val Lys Lys Glu  Asp Gly Ile 
    1670                 1675                 1680             


Asn Asp  Met Phe Asn Phe Glu  Thr Phe Gly Asn Ser  Met Ile Cys 
    1685                 1690                 1695             


Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp Asp Gly  Leu Leu Ala 
    1700                 1705                 1710             


Pro Ile  Leu Asn Ser Lys Pro  Pro Asp Cys Asp Pro  Lys Lys Val 
    1715                 1720                 1725             


His Pro  Gly Ser Ser Val Glu  Gly Asp Cys Gly Asn  Pro Ser Val 
    1730                 1735                 1740             


Gly Ile  Phe Tyr Phe Val Ser  Tyr Ile Ile Ile Ser  Phe Leu Val 
    1745                 1750                 1755             


Val Val  Asn Met Tyr Ile Ala  Val Ile Leu Glu Asn  Phe Ser Val 
    1760                 1765                 1770             


Ala Thr  Glu Glu Ser Thr Glu  Pro Leu Ser Glu Asp  Asp Phe Asp 
    1775                 1780                 1785             


Met Phe  Tyr Glu Ile Trp Glu  Lys Phe Asp Pro Glu  Ala Thr Gln 
    1790                 1795                 1800             


Phe Ile  Glu Tyr Ser Val Leu  Ser Asp Phe Ala Asp  Ala Leu Ser 
    1805                 1810                 1815             


Glu Pro  Leu Arg Ile Ala Lys  Pro Asn Gln Ile Ser  Leu Ile Asn 
    1820                 1825                 1830             


Met Asp  Leu Pro Met Val Ser  Gly Asp Arg Ile His  Cys Met Asp 
    1835                 1840                 1845             


Ile Leu  Phe Ala Phe Thr Lys  Arg Val Leu Gly Glu  Ser Gly Glu 
    1850                 1855                 1860             


Met Asp  Ala Leu Lys Ile Gln  Met Glu Glu Lys Phe  Met Ala Ala 
    1865                 1870                 1875             


Asn Pro  Ser Lys Ile Ser Tyr  Glu Pro Ile Thr Thr  Thr Leu Arg 
    1880                 1885                 1890             


Arg Lys  His Glu Glu Val Ser  Ala Met Val Ile Gln  Arg Ala Phe 
    1895                 1900                 1905             


Arg Arg  His Leu Leu Gln Arg  Ser Leu Lys His Ala  Ser Phe Leu 
    1910                 1915                 1920             


Phe Arg  Gln Gln Ala Gly Ser  Gly Leu Ser Glu Glu  Asp Ala Pro 
    1925                 1930                 1935             


Glu Arg  Glu Gly Leu Ile Ala  Tyr Val Met Ser Glu  Asn Phe Ser 
    1940                 1945                 1950             


Arg Pro  Leu Gly Pro Pro Ser  Ser Ser Ser Ile Ser  Ser Thr Ser 
    1955                 1960                 1965             


Phe Pro  Pro Ser Tyr Asp Ser  Val Thr Arg Ala Thr  Ser Asp Asn 
    1970                 1975                 1980             


Leu Gln  Val Arg Gly Ser Asp  Tyr Ser His Ser Glu  Asp Leu Ala 
    1985                 1990                 1995             


Asp Phe  Pro Pro Ser Pro Asp  Arg Asp Arg Glu Ser  Ile Val Ser 
    2000                 2005                 2010             


Gly Arg  Gly Ser Gly Ala Thr  Asn Phe Ser Leu Leu  Lys Gln Ala 
    2015                 2020                 2025             


Gly Asp  Val Glu Glu Asn Pro  Gly Pro Met Gly Arg  Leu Leu Ala 
    2030                 2035                 2040             


Leu Val  Val Gly Ala Ala Leu  Val Ser Ser Ala Cys  Gly Gly Cys 
    2045                 2050                 2055             


Val Glu  Val Asp Ser Glu Thr  Glu Ala Val Tyr Gly  Met Thr Phe 
    2060                 2065                 2070             


Lys Ile  Leu Cys Ile Ser Cys  Lys Arg Arg Ser Glu  Thr Asn Ala 
    2075                 2080                 2085             


Glu Thr  Phe Thr Glu Trp Thr  Phe Arg Gln Lys Gly  Thr Glu Glu 
    2090                 2095                 2100             


Phe Val  Lys Ile Leu Arg Tyr  Glu Asn Glu Val Leu  Gln Leu Glu 
    2105                 2110                 2115             


Glu Asp  Glu Arg Phe Glu Gly  Arg Val Val Trp Asn  Gly Ser Arg 
    2120                 2125                 2130             


Gly Thr  Lys Asp Leu Gln Asp  Leu Ser Ile Phe Ile  Thr Asn Val 
    2135                 2140                 2145             


Thr Tyr  Asn His Ser Gly Asp  Tyr Glu Cys His Val  Tyr Arg Leu 
    2150                 2155                 2160             


Leu Phe  Phe Glu Asn Tyr Glu  His Asn Thr Ser Val  Val Lys Lys 
    2165                 2170                 2175             


Ile His  Ile Glu Val Val Asp  Lys Ala Asn Arg Asp  Met Ala Ser 
    2180                 2185                 2190             


Ile Val  Ser Glu Ile Met Met  Tyr Val Leu Ile Val  Val Leu Thr 
    2195                 2200                 2205             


Ile Trp  Leu Val Ala Glu Met  Ile Tyr Cys Tyr Lys  Lys Ile Ala 
    2210                 2215                 2220             


Ala Ala  Thr Glu Thr Ala Ala  Gln Glu Asn Ala Ser  Glu Tyr Leu 
    2225                 2230                 2235             


Ala Ile  Thr Ser Glu Ser Lys  Glu Asn Cys Thr Gly  Val Gln Val 
    2240                 2245                 2250             


Ala Glu  Gly Ser Gly Ala Thr  Asn Phe Ser Leu Leu  Lys Gln Ala 
    2255                 2260                 2265             


Gly Asp  Val Glu Glu Asn Pro  Gly Pro Met His Arg  Asp Ala Trp 
    2270                 2275                 2280             


Leu Pro  Arg Pro Ala Phe Ser  Leu Thr Gly Leu Ser  Leu Phe Phe 
    2285                 2290                 2295             


Ser Leu  Val Pro Pro Gly Arg  Ser Met Glu Val Thr  Val Pro Ala 
    2300                 2305                 2310             


Thr Leu  Asn Val Leu Asn Gly  Ser Asp Ala Arg Leu  Pro Cys Thr 
    2315                 2320                 2325             


Phe Asn  Ser Cys Tyr Thr Val  Asn His Lys Gln Phe  Ser Leu Asn 
    2330                 2335                 2340             


Trp Thr  Tyr Gln Glu Cys Asn  Asn Cys Ser Glu Glu  Met Phe Leu 
    2345                 2350                 2355             


Gln Phe  Arg Met Lys Ile Ile  Asn Leu Lys Leu Glu  Arg Phe Gln 
    2360                 2365                 2370             


Asp Arg  Val Glu Phe Ser Gly  Asn Pro Ser Lys Tyr  Asp Val Ser 
    2375                 2380                 2385             


Val Met  Leu Arg Asn Val Gln  Pro Glu Asp Glu Gly  Ile Tyr Asn 
    2390                 2395                 2400             


Cys Tyr  Ile Met Asn Pro Pro  Asp Arg His Arg Gly  His Gly Lys 
    2405                 2410                 2415             


Ile His  Leu Gln Val Leu Met  Glu Glu Pro Pro Glu  Arg Asp Ser 
    2420                 2425                 2430             


Thr Val  Ala Val Ile Val Gly  Ala Ser Val Gly Gly  Phe Leu Ala 
    2435                 2440                 2445             


Val Val  Ile Leu Val Leu Met  Val Val Lys Cys Val  Arg Arg Lys 
    2450                 2455                 2460             


Lys Glu  Gln Lys Leu Ser Thr  Asp Asp Leu Lys Thr  Glu Glu Glu 
    2465                 2470                 2475             


Gly Lys  Thr Asp Gly Glu Gly  Asn Pro Asp Asp Gly  Ala Lys Gly 
    2480                 2485                 2490             


Ser Gly  Ala Thr Asn Phe Ser  Leu Leu Lys Gln Ala  Gly Asp Val 
    2495                 2500                 2505             


Glu Glu  Asn Pro Gly Pro Met  Pro Ala Phe Asn Arg  Leu Phe Pro 
    2510                 2515                 2520             


Leu Ala  Ser Leu Val Leu Ile  Tyr Trp Val Ser Val  Cys Phe Pro 
    2525                 2530                 2535             


Val Cys  Val Glu Val Pro Ser  Glu Thr Glu Ala Val  Gln Gly Asn 
    2540                 2545                 2550             


Pro Met  Lys Leu Arg Cys Ile  Ser Cys Met Lys Arg  Glu Glu Val 
    2555                 2560                 2565             


Glu Ala  Thr Thr Val Val Glu  Trp Phe Tyr Arg Pro  Glu Gly Gly 
    2570                 2575                 2580             


Lys Asp  Phe Leu Ile Tyr Glu  Tyr Arg Asn Gly His  Gln Glu Val 
    2585                 2590                 2595             


Glu Ser  Pro Phe Gln Gly Arg  Leu Gln Trp Asn Gly  Ser Lys Asp 
    2600                 2605                 2610             


Leu Gln  Asp Val Ser Ile Thr  Val Leu Asn Val Thr  Leu Asn Asp 
    2615                 2620                 2625             


Ser Gly  Leu Tyr Thr Cys Asn  Val Ser Arg Glu Phe  Glu Phe Glu 
    2630                 2635                 2640             


Ala His  Arg Pro Phe Val Lys  Thr Thr Arg Leu Ile  Pro Leu Arg 
    2645                 2650                 2655             


Val Thr  Glu Glu Ala Gly Glu  Asp Phe Thr Ser Val  Val Ser Glu 
    2660                 2665                 2670             


Ile Met  Met Tyr Ile Leu Leu  Val Phe Leu Thr Leu  Trp Leu Leu 
    2675                 2680                 2685             


Ile Glu  Met Ile Tyr Cys Tyr  Arg Lys Val Ser Lys  Ala Glu Glu 
    2690                 2695                 2700             


Ala Ala  Gln Glu Asn Ala Ser  Asp Tyr Leu Ala Ile  Pro Ser Glu 
    2705                 2710                 2715             


Asn Lys  Glu Asn Ser Ala Val  Pro Val Glu Glu 
    2720                 2725                 


<210>  21
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta1-beta2-beta3 viral P2A

<400>  21

Met Gly Arg Leu Leu Ala Leu Val Val Gly Ala Ala Leu Val Ser Ser 
1               5                   10                  15      


Ala Cys Gly Gly Cys Val Glu Val Asp Ser Glu Thr Glu Ala Val Tyr 
            20                  25                  30          


Gly Met Thr Phe Lys Ile Leu Cys Ile Ser Cys Lys Arg Arg Ser Glu 
        35                  40                  45              


Thr Asn Ala Glu Thr Phe Thr Glu Trp Thr Phe Arg Gln Lys Gly Thr 
    50                  55                  60                  


Glu Glu Phe Val Lys Ile Leu Arg Tyr Glu Asn Glu Val Leu Gln Leu 
65                  70                  75                  80  


Glu Glu Asp Glu Arg Phe Glu Gly Arg Val Val Trp Asn Gly Ser Arg 
                85                  90                  95      


Gly Thr Lys Asp Leu Gln Asp Leu Ser Ile Phe Ile Thr Asn Val Thr 
            100                 105                 110         


Tyr Asn His Ser Gly Asp Tyr Glu Cys His Val Tyr Arg Leu Leu Phe 
        115                 120                 125             


Phe Glu Asn Tyr Glu His Asn Thr Ser Val Val Lys Lys Ile His Ile 
    130                 135                 140                 


Glu Val Val Asp Lys Ala Asn Arg Asp Met Ala Ser Ile Val Ser Glu 
145                 150                 155                 160 


Ile Met Met Tyr Val Leu Ile Val Val Leu Thr Ile Trp Leu Val Ala 
                165                 170                 175     


Glu Met Ile Tyr Cys Tyr Lys Lys Ile Ala Ala Ala Thr Glu Thr Ala 
            180                 185                 190         


Ala Gln Glu Asn Ala Ser Glu Tyr Leu Ala Ile Thr Ser Glu Ser Lys 
        195                 200                 205             


Glu Asn Cys Thr Gly Val Gln Val Ala Glu Gly Ser Gly Ala Thr Asn 
    210                 215                 220                 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
225                 230                 235                 240 


Met His Arg Asp Ala Trp Leu Pro Arg Pro Ala Phe Ser Leu Thr Gly 
                245                 250                 255     


Leu Ser Leu Phe Phe Ser Leu Val Pro Pro Gly Arg Ser Met Glu Val 
            260                 265                 270         


Thr Val Pro Ala Thr Leu Asn Val Leu Asn Gly Ser Asp Ala Arg Leu 
        275                 280                 285             


Pro Cys Thr Phe Asn Ser Cys Tyr Thr Val Asn His Lys Gln Phe Ser 
    290                 295                 300                 


Leu Asn Trp Thr Tyr Gln Glu Cys Asn Asn Cys Ser Glu Glu Met Phe 
305                 310                 315                 320 


Leu Gln Phe Arg Met Lys Ile Ile Asn Leu Lys Leu Glu Arg Phe Gln 
                325                 330                 335     


Asp Arg Val Glu Phe Ser Gly Asn Pro Ser Lys Tyr Asp Val Ser Val 
            340                 345                 350         


Met Leu Arg Asn Val Gln Pro Glu Asp Glu Gly Ile Tyr Asn Cys Tyr 
        355                 360                 365             


Ile Met Asn Pro Pro Asp Arg His Arg Gly His Gly Lys Ile His Leu 
    370                 375                 380                 


Gln Val Leu Met Glu Glu Pro Pro Glu Arg Asp Ser Thr Val Ala Val 
385                 390                 395                 400 


Ile Val Gly Ala Ser Val Gly Gly Phe Leu Ala Val Val Ile Leu Val 
                405                 410                 415     


Leu Met Val Val Lys Cys Val Arg Arg Lys Lys Glu Gln Lys Leu Ser 
            420                 425                 430         


Thr Asp Asp Leu Lys Thr Glu Glu Glu Gly Lys Thr Asp Gly Glu Gly 
        435                 440                 445             


Asn Pro Asp Asp Gly Ala Lys Gly Ser Gly Ala Thr Asn Phe Ser Leu 
    450                 455                 460                 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Pro Ala 
465                 470                 475                 480 


Phe Asn Arg Leu Phe Pro Leu Ala Ser Leu Val Leu Ile Tyr Trp Val 
                485                 490                 495     


Ser Val Cys Phe Pro Val Cys Val Glu Val Pro Ser Glu Thr Glu Ala 
            500                 505                 510         


Val Gln Gly Asn Pro Met Lys Leu Arg Cys Ile Ser Cys Met Lys Arg 
        515                 520                 525             


Glu Glu Val Glu Ala Thr Thr Val Val Glu Trp Phe Tyr Arg Pro Glu 
    530                 535                 540                 


Gly Gly Lys Asp Phe Leu Ile Tyr Glu Tyr Arg Asn Gly His Gln Glu 
545                 550                 555                 560 


Val Glu Ser Pro Phe Gln Gly Arg Leu Gln Trp Asn Gly Ser Lys Asp 
                565                 570                 575     


Leu Gln Asp Val Ser Ile Thr Val Leu Asn Val Thr Leu Asn Asp Ser 
            580                 585                 590         


Gly Leu Tyr Thr Cys Asn Val Ser Arg Glu Phe Glu Phe Glu Ala His 
        595                 600                 605             


Arg Pro Phe Val Lys Thr Thr Arg Leu Ile Pro Leu Arg Val Thr Glu 
    610                 615                 620                 


Glu Ala Gly Glu Asp Phe Thr Ser Val Val Ser Glu Ile Met Met Tyr 
625                 630                 635                 640 


Ile Leu Leu Val Phe Leu Thr Leu Trp Leu Leu Ile Glu Met Ile Tyr 
                645                 650                 655     


Cys Tyr Arg Lys Val Ser Lys Ala Glu Glu Ala Ala Gln Glu Asn Ala 
            660                 665                 670         


Ser Asp Tyr Leu Ala Ile Pro Ser Glu Asn Lys Glu Asn Ser Ala Val 
        675                 680                 685             


Pro Val Glu Glu 
    690         


<210>  22
<211>  2732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav1.5-b1-beta2-beta3 viral P2A

<400>  22

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Glu Ser Gln Pro  Val Ser Gly 
    1070                 1075                 1080             


Gly Pro  Glu Ala Pro Pro Asp  Ser Arg Thr Trp Ser  Gln Val Ser 
    1085                 1090                 1095             


Ala Thr  Ala Ser Ser Glu Ala  Glu Ala Ser Ala Ser  Gln Ala Asp 
    1100                 1105                 1110             


Trp Arg  Gln Gln Trp Lys Ala  Glu Pro Gln Ala Pro  Gly Cys Gly 
    1115                 1120                 1125             


Glu Thr  Pro Glu Asp Ser Cys  Ser Glu Gly Ser Thr  Ala Asp Met 
    1130                 1135                 1140             


Thr Asn  Thr Ala Glu Leu Leu  Glu Gln Ile Pro Asp  Leu Gly Gln 
    1145                 1150                 1155             


Asp Val  Lys Asp Pro Glu Asp  Cys Phe Thr Glu Gly  Cys Val Arg 
    1160                 1165                 1170             


Arg Cys  Pro Cys Cys Ala Val  Asp Thr Thr Gln Ala  Pro Gly Lys 
    1175                 1180                 1185             


Val Trp  Trp Arg Leu Arg Lys  Thr Cys Tyr His Ile  Val Glu His 
    1190                 1195                 1200             


Ser Trp  Phe Glu Thr Phe Ile  Ile Phe Met Ile Leu  Leu Ser Ser 
    1205                 1210                 1215             


Gly Ala  Leu Ala Phe Glu Asp  Ile Tyr Leu Glu Glu  Arg Lys Thr 
    1220                 1225                 1230             


Ile Lys  Val Leu Leu Glu Tyr  Ala Asp Lys Met Phe  Thr Tyr Val 
    1235                 1240                 1245             


Phe Val  Leu Glu Met Leu Leu  Lys Trp Val Ala Tyr  Gly Phe Lys 
    1250                 1255                 1260             


Lys Tyr  Phe Thr Asn Ala Trp  Cys Trp Leu Asp Phe  Leu Ile Val 
    1265                 1270                 1275             


Asp Val  Ser Leu Val Ser Leu  Val Ala Asn Thr Leu  Gly Phe Ala 
    1280                 1285                 1290             


Glu Met  Gly Pro Ile Lys Ser  Leu Arg Thr Leu Arg  Ala Leu Arg 
    1295                 1300                 1305             


Pro Leu  Arg Ala Leu Ser Arg  Phe Glu Gly Met Arg  Val Val Val 
    1310                 1315                 1320             


Asn Ala  Leu Val Gly Ala Ile  Pro Ser Ile Met Asn  Val Leu Leu 
    1325                 1330                 1335             


Val Cys  Leu Ile Phe Trp Leu  Ile Phe Ser Ile Met  Gly Val Asn 
    1340                 1345                 1350             


Leu Phe  Ala Gly Lys Phe Gly  Arg Cys Ile Asn Gln  Thr Glu Gly 
    1355                 1360                 1365             


Asp Leu  Pro Leu Asn Tyr Thr  Ile Val Asn Asn Lys  Ser Gln Cys 
    1370                 1375                 1380             


Glu Ser  Leu Asn Leu Thr Gly  Glu Leu Tyr Trp Thr  Lys Val Lys 
    1385                 1390                 1395             


Val Asn  Phe Asp Asn Val Gly  Ala Gly Tyr Leu Ala  Leu Leu Gln 
    1400                 1405                 1410             


Val Ala  Thr Phe Lys Gly Trp  Met Asp Ile Met Tyr  Ala Ala Val 
    1415                 1420                 1425             


Asp Ser  Arg Gly Tyr Glu Glu  Gln Pro Gln Trp Glu  Tyr Asn Leu 
    1430                 1435                 1440             


Tyr Met  Tyr Ile Tyr Phe Val  Ile Phe Ile Ile Phe  Gly Ser Phe 
    1445                 1450                 1455             


Phe Thr  Leu Asn Leu Phe Ile  Gly Val Ile Ile Asp  Asn Phe Asn 
    1460                 1465                 1470             


Gln Gln  Lys Lys Lys Leu Gly  Gly Gln Asp Ile Phe  Met Thr Glu 
    1475                 1480                 1485             


Glu Gln  Lys Lys Tyr Tyr Asn  Ala Met Lys Lys Leu  Gly Ser Lys 
    1490                 1495                 1500             


Lys Pro  Gln Lys Pro Ile Pro  Arg Pro Leu Asn Lys  Tyr Gln Gly 
    1505                 1510                 1515             


Phe Ile  Phe Asp Ile Val Thr  Lys Gln Ala Phe Asp  Val Thr Ile 
    1520                 1525                 1530             


Met Phe  Leu Ile Cys Leu Asn  Met Val Thr Met Met  Val Glu Thr 
    1535                 1540                 1545             


Asp Asp  Gln Ser Pro Glu Lys  Ile Asn Ile Leu Ala  Lys Ile Asn 
    1550                 1555                 1560             


Leu Leu  Phe Val Ala Ile Phe  Thr Gly Glu Cys Ile  Val Lys Leu 
    1565                 1570                 1575             


Ala Ala  Leu Arg His Tyr Tyr  Phe Thr Asn Ser Trp  Asn Ile Phe 
    1580                 1585                 1590             


Asp Phe  Val Val Val Ile Leu  Ser Ile Val Gly Thr  Val Leu Ser 
    1595                 1600                 1605             


Asp Ile  Ile Gln Lys Tyr Phe  Phe Ser Pro Thr Leu  Phe Arg Val 
    1610                 1615                 1620             


Ile Arg  Leu Ala Arg Ile Gly  Arg Ile Leu Arg Leu  Ile Arg Gly 
    1625                 1630                 1635             


Ala Lys  Gly Ile Arg Thr Leu  Leu Phe Ala Leu Met  Met Ser Leu 
    1640                 1645                 1650             


Pro Ala  Leu Phe Asn Ile Gly  Leu Leu Leu Phe Leu  Val Met Phe 
    1655                 1660                 1665             


Ile Tyr  Ser Ile Phe Gly Met  Ala Asn Phe Ala Tyr  Val Lys Trp 
    1670                 1675                 1680             


Glu Ala  Gly Ile Asp Asp Met  Phe Asn Phe Gln Thr  Phe Ala Asn 
    1685                 1690                 1695             


Ser Met  Leu Cys Leu Phe Gln  Ile Thr Thr Ser Ala  Gly Trp Asp 
    1700                 1705                 1710             


Gly Leu  Leu Ser Pro Ile Leu  Asn Thr Gly Pro Pro  Tyr Cys Asp 
    1715                 1720                 1725             


Pro Thr  Leu Pro Asn Ser Asn  Gly Ser Arg Gly Asp  Cys Gly Ser 
    1730                 1735                 1740             


Pro Ala  Val Gly Ile Leu Phe  Phe Thr Thr Tyr Ile  Ile Ile Ser 
    1745                 1750                 1755             


Phe Leu  Ile Val Val Asn Met  Tyr Ile Ala Ile Ile  Leu Glu Asn 
    1760                 1765                 1770             


Phe Ser  Val Ala Thr Glu Glu  Ser Thr Glu Pro Leu  Ser Glu Asp 
    1775                 1780                 1785             


Asp Phe  Asp Met Phe Tyr Glu  Ile Trp Glu Lys Phe  Asp Pro Glu 
    1790                 1795                 1800             


Ala Thr  Gln Phe Ile Glu Tyr  Ser Val Leu Ser Asp  Phe Ala Asp 
    1805                 1810                 1815             


Ala Leu  Ser Glu Pro Leu Arg  Ile Ala Lys Pro Asn  Gln Ile Ser 
    1820                 1825                 1830             


Leu Ile  Asn Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1835                 1840                 1845             


Cys Met  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1850                 1855                 1860             


Ser Gly  Glu Met Asp Ala Leu  Lys Ile Gln Met Glu  Glu Lys Phe 
    1865                 1870                 1875             


Met Ala  Ala Asn Pro Ser Lys  Ile Ser Tyr Glu Pro  Ile Thr Thr 
    1880                 1885                 1890             


Thr Leu  Arg Arg Lys His Glu  Glu Val Ser Ala Met  Val Ile Gln 
    1895                 1900                 1905             


Arg Ala  Phe Arg Arg His Leu  Leu Gln Arg Ser Leu  Lys His Ala 
    1910                 1915                 1920             


Ser Phe  Leu Phe Arg Gln Gln  Ala Gly Ser Gly Leu  Ser Glu Glu 
    1925                 1930                 1935             


Asp Ala  Pro Glu Arg Glu Gly  Leu Ile Ala Tyr Val  Met Ser Glu 
    1940                 1945                 1950             


Asn Phe  Ser Arg Pro Leu Gly  Pro Pro Ser Ser Ser  Ser Ile Ser 
    1955                 1960                 1965             


Ser Thr  Ser Phe Pro Pro Ser  Tyr Asp Ser Val Thr  Arg Ala Thr 
    1970                 1975                 1980             


Ser Asp  Asn Leu Gln Val Arg  Gly Ser Asp Tyr Ser  His Ser Glu 
    1985                 1990                 1995             


Asp Leu  Ala Asp Phe Pro Pro  Ser Pro Asp Arg Asp  Arg Glu Ser 
    2000                 2005                 2010             


Ile Val  Ser Gly Arg Gly Ser  Gly Ala Thr Asn Phe  Ser Leu Leu 
    2015                 2020                 2025             


Lys Gln  Ala Gly Asp Val Glu  Glu Asn Pro Gly Pro  Met Gly Arg 
    2030                 2035                 2040             


Leu Leu  Ala Leu Val Val Gly  Ala Ala Leu Val Ser  Ser Ala Cys 
    2045                 2050                 2055             


Gly Gly  Cys Val Glu Val Asp  Ser Glu Thr Glu Ala  Val Tyr Gly 
    2060                 2065                 2070             


Met Thr  Phe Lys Ile Leu Cys  Ile Ser Cys Lys Arg  Arg Ser Glu 
    2075                 2080                 2085             


Thr Asn  Ala Glu Thr Phe Thr  Glu Trp Thr Phe Arg  Gln Lys Gly 
    2090                 2095                 2100             


Thr Glu  Glu Phe Val Lys Ile  Leu Arg Tyr Glu Asn  Glu Val Leu 
    2105                 2110                 2115             


Gln Leu  Glu Glu Asp Glu Arg  Phe Glu Gly Arg Val  Val Trp Asn 
    2120                 2125                 2130             


Gly Ser  Arg Gly Thr Lys Asp  Leu Gln Asp Leu Ser  Ile Phe Ile 
    2135                 2140                 2145             


Thr Asn  Val Thr Tyr Asn His  Ser Gly Asp Tyr Glu  Cys His Val 
    2150                 2155                 2160             


Tyr Arg  Leu Leu Phe Phe Glu  Asn Tyr Glu His Asn  Thr Ser Val 
    2165                 2170                 2175             


Val Lys  Lys Ile His Ile Glu  Val Val Asp Lys Ala  Asn Arg Asp 
    2180                 2185                 2190             


Met Ala  Ser Ile Val Ser Glu  Ile Met Met Tyr Val  Leu Ile Val 
    2195                 2200                 2205             


Val Leu  Thr Ile Trp Leu Val  Ala Glu Met Ile Tyr  Cys Tyr Lys 
    2210                 2215                 2220             


Lys Ile  Ala Ala Ala Thr Glu  Thr Ala Ala Gln Glu  Asn Ala Ser 
    2225                 2230                 2235             


Glu Tyr  Leu Ala Ile Thr Ser  Glu Ser Lys Glu Asn  Cys Thr Gly 
    2240                 2245                 2250             


Val Gln  Val Ala Glu Gly Ser  Gly Ala Thr Asn Phe  Ser Leu Leu 
    2255                 2260                 2265             


Lys Gln  Ala Gly Asp Val Glu  Glu Asn Pro Gly Pro  Met His Arg 
    2270                 2275                 2280             


Asp Ala  Trp Leu Pro Arg Pro  Ala Phe Ser Leu Thr  Gly Leu Ser 
    2285                 2290                 2295             


Leu Phe  Phe Ser Leu Val Pro  Pro Gly Arg Ser Met  Glu Val Thr 
    2300                 2305                 2310             


Val Pro  Ala Thr Leu Asn Val  Leu Asn Gly Ser Asp  Ala Arg Leu 
    2315                 2320                 2325             


Pro Cys  Thr Phe Asn Ser Cys  Tyr Thr Val Asn His  Lys Gln Phe 
    2330                 2335                 2340             


Ser Leu  Asn Trp Thr Tyr Gln  Glu Cys Asn Asn Cys  Ser Glu Glu 
    2345                 2350                 2355             


Met Phe  Leu Gln Phe Arg Met  Lys Ile Ile Asn Leu  Lys Leu Glu 
    2360                 2365                 2370             


Arg Phe  Gln Asp Arg Val Glu  Phe Ser Gly Asn Pro  Ser Lys Tyr 
    2375                 2380                 2385             


Asp Val  Ser Val Met Leu Arg  Asn Val Gln Pro Glu  Asp Glu Gly 
    2390                 2395                 2400             


Ile Tyr  Asn Cys Tyr Ile Met  Asn Pro Pro Asp Arg  His Arg Gly 
    2405                 2410                 2415             


His Gly  Lys Ile His Leu Gln  Val Leu Met Glu Glu  Pro Pro Glu 
    2420                 2425                 2430             


Arg Asp  Ser Thr Val Ala Val  Ile Val Gly Ala Ser  Val Gly Gly 
    2435                 2440                 2445             


Phe Leu  Ala Val Val Ile Leu  Val Leu Met Val Val  Lys Cys Val 
    2450                 2455                 2460             


Arg Arg  Lys Lys Glu Gln Lys  Leu Ser Thr Asp Asp  Leu Lys Thr 
    2465                 2470                 2475             


Glu Glu  Glu Gly Lys Thr Asp  Gly Glu Gly Asn Pro  Asp Asp Gly 
    2480                 2485                 2490             


Ala Lys  Gly Ser Gly Ala Thr  Asn Phe Ser Leu Leu  Lys Gln Ala 
    2495                 2500                 2505             


Gly Asp  Val Glu Glu Asn Pro  Gly Pro Met Pro Ala  Phe Asn Arg 
    2510                 2515                 2520             


Leu Phe  Pro Leu Ala Ser Leu  Val Leu Ile Tyr Trp  Val Ser Val 
    2525                 2530                 2535             


Cys Phe  Pro Val Cys Val Glu  Val Pro Ser Glu Thr  Glu Ala Val 
    2540                 2545                 2550             


Gln Gly  Asn Pro Met Lys Leu  Arg Cys Ile Ser Cys  Met Lys Arg 
    2555                 2560                 2565             


Glu Glu  Val Glu Ala Thr Thr  Val Val Glu Trp Phe  Tyr Arg Pro 
    2570                 2575                 2580             


Glu Gly  Gly Lys Asp Phe Leu  Ile Tyr Glu Tyr Arg  Asn Gly His 
    2585                 2590                 2595             


Gln Glu  Val Glu Ser Pro Phe  Gln Gly Arg Leu Gln  Trp Asn Gly 
    2600                 2605                 2610             


Ser Lys  Asp Leu Gln Asp Val  Ser Ile Thr Val Leu  Asn Val Thr 
    2615                 2620                 2625             


Leu Asn  Asp Ser Gly Leu Tyr  Thr Cys Asn Val Ser  Arg Glu Phe 
    2630                 2635                 2640             


Glu Phe  Glu Ala His Arg Pro  Phe Val Lys Thr Thr  Arg Leu Ile 
    2645                 2650                 2655             


Pro Leu  Arg Val Thr Glu Glu  Ala Gly Glu Asp Phe  Thr Ser Val 
    2660                 2665                 2670             


Val Ser  Glu Ile Met Met Tyr  Ile Leu Leu Val Phe  Leu Thr Leu 
    2675                 2680                 2685             


Trp Leu  Leu Ile Glu Met Ile  Tyr Cys Tyr Arg Lys  Val Ser Lys 
    2690                 2695                 2700             


Ala Glu  Glu Ala Ala Gln Glu  Asn Ala Ser Asp Tyr  Leu Ala Ile 
    2705                 2710                 2715             


Pro Ser  Glu Asn Lys Glu Asn  Ser Ala Val Pro Val  Glu Glu 
    2720                 2725                 2730         


<210>  23
<211>  2009
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav1.1 (alpha subunit)

<400>  23

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Ala Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Glu  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  24
<211>  2005
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav1.2 (alpha subunit)

<400>  24

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Val Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe 
        275                 280                 285             


Glu Ile Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Thr Phe Asn Arg Thr Val Ser Ile Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Asn Asp Arg Val Arg Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg His Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Val Leu Pro Ile Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Thr Leu Thr Ser Ala Gly Gln Leu Leu Pro Glu 
            660                 665                 670         


Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser Tyr 
        675                 680                 685             


His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ser Arg Gln Arg Ala 
    690                 695                 700                 


Met Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
705                 710                 715                 720 


Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met Cys 
                725                 730                 735     


Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Leu Val 
            740                 745                 750         


Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
        755                 760                 765             


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
    770                 775                 780                 


Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr Gly 
785                 790                 795                 800 


Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro Tyr 
                805                 810                 815     


Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val Ser 
            820                 825                 830         


Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
        835                 840                 845             


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
    850                 855                 860                 


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
865                 870                 875                 880 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
                885                 890                 895     


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
            900                 905                 910         


Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp Phe 
        915                 920                 925             


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
    930                 935                 940                 


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
945                 950                 955                 960 


Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
                965                 970                 975     


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
            980                 985                 990         


Ala Thr Asp Asp Asp Asn Glu Met  Asn Asn Leu Gln Ile  Ala Val Gly 
        995                 1000                 1005             


Arg Met  Gln Lys Gly Ile Asp  Phe Val Lys Arg Lys  Ile Arg Glu 
    1010                 1015                 1020             


Phe Ile  Gln Lys Ala Phe Val  Arg Lys Gln Lys Ala  Leu Asp Glu 
    1025                 1030                 1035             


Ile Lys  Pro Leu Glu Asp Leu  Asn Asn Lys Lys Asp  Ser Cys Ile 
    1040                 1045                 1050             


Ser Asn  His Thr Thr Ile Glu  Ile Gly Lys Asp Leu  Asn Tyr Leu 
    1055                 1060                 1065             


Lys Asp  Gly Asn Gly Thr Thr  Ser Gly Ile Gly Ser  Ser Val Glu 
    1070                 1075                 1080             


Lys Tyr  Val Val Asp Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn 
    1085                 1090                 1095             


Pro Ser  Leu Thr Val Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp 
    1100                 1105                 1110             


Phe Glu  Asn Leu Asn Thr Glu  Glu Phe Ser Ser Glu  Ser Asp Met 
    1115                 1120                 1125             


Glu Glu  Ser Lys Glu Lys Leu  Asn Ala Thr Ser Ser  Ser Glu Gly 
    1130                 1135                 1140             


Ser Thr  Val Asp Ile Gly Ala  Pro Ala Glu Gly Glu  Gln Pro Glu 
    1145                 1150                 1155             


Val Glu  Pro Glu Glu Ser Leu  Glu Pro Glu Ala Cys  Phe Thr Glu 
    1160                 1165                 1170             


Asp Cys  Val Arg Lys Phe Lys  Cys Cys Gln Ile Ser  Ile Glu Glu 
    1175                 1180                 1185             


Gly Lys  Gly Lys Leu Trp Trp  Asn Leu Arg Lys Thr  Cys Tyr Lys 
    1190                 1195                 1200             


Ile Val  Glu His Asn Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile 
    1205                 1210                 1215             


Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Glu 
    1220                 1225                 1230             


Gln Arg  Lys Thr Ile Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val 
    1235                 1240                 1245             


Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala 
    1250                 1255                 1260             


Tyr Gly  Phe Gln Val Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp 
    1265                 1270                 1275             


Phe Leu  Ile Val Asp Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala 
    1280                 1285                 1290             


Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu 
    1295                 1300                 1305             


Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met 
    1310                 1315                 1320             


Arg Val  Val Val Asn Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met 
    1325                 1330                 1335             


Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile 
    1340                 1345                 1350             


Met Gly  Val Asn Leu Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn 
    1355                 1360                 1365             


Tyr Thr  Thr Gly Glu Met Phe  Asp Val Ser Val Val  Asn Asn Tyr 
    1370                 1375                 1380             


Ser Glu  Cys Lys Ala Leu Ile  Glu Ser Asn Gln Thr  Ala Arg Trp 
    1385                 1390                 1395             


Lys Asn  Val Lys Val Asn Phe  Asp Asn Val Gly Leu  Gly Tyr Leu 
    1400                 1405                 1410             


Ser Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met 
    1415                 1420                 1425             


Tyr Ala  Ala Val Asp Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr 
    1430                 1435                 1440             


Glu Asp  Asn Leu Tyr Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile 
    1445                 1450                 1455             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1460                 1465                 1470             


Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile 
    1475                 1480                 1485             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1490                 1495                 1500             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn 
    1505                 1510                 1515             


Lys Phe  Gln Gly Met Val Phe  Asp Phe Val Thr Lys  Gln Val Phe 
    1520                 1525                 1530             


Asp Ile  Ser Ile Met Ile Leu  Ile Cys Leu Asn Met  Val Thr Met 
    1535                 1540                 1545             


Met Val  Glu Thr Asp Asp Gln  Ser Gln Glu Met Thr  Asn Ile Leu 
    1550                 1555                 1560             


Tyr Trp  Ile Asn Leu Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys 
    1565                 1570                 1575             


Val Leu  Lys Leu Ile Ser Leu  Arg Tyr Tyr Tyr Phe  Thr Ile Gly 
    1580                 1585                 1590             


Trp Asn  Ile Phe Asp Phe Val  Val Val Ile Leu Ser  Ile Val Gly 
    1595                 1600                 1605             


Met Phe  Leu Ala Glu Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr 
    1610                 1615                 1620             


Leu Phe  Arg Val Ile Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg 
    1625                 1630                 1635             


Leu Ile  Lys Gly Ala Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu 
    1640                 1645                 1650             


Met Met  Ser Leu Pro Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe 
    1655                 1660                 1665             


Leu Val  Met Phe Ile Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala 
    1670                 1675                 1680             


Tyr Val  Lys Arg Glu Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu 
    1685                 1690                 1695             


Thr Phe  Gly Asn Ser Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser 
    1700                 1705                 1710             


Ala Gly  Trp Asp Gly Leu Leu  Ala Pro Ile Leu Asn  Ser Gly Pro 
    1715                 1720                 1725             


Pro Asp  Cys Asp Pro Asp Lys  Asp His Pro Gly Ser  Ser Val Lys 
    1730                 1735                 1740             


Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser 
    1745                 1750                 1755             


Tyr Ile  Ile Ile Ser Phe Leu  Val Val Val Asn Met  Tyr Ile Ala 
    1760                 1765                 1770             


Val Ile  Leu Glu Asn Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu 
    1775                 1780                 1785             


Pro Leu  Ser Glu Asp Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu 
    1790                 1795                 1800             


Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile Glu Phe  Ala Lys Leu 
    1805                 1810                 1815             


Ser Asp  Phe Ala Asp Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys 
    1820                 1825                 1830             


Pro Asn  Lys Val Gln Leu Ile  Ala Met Asp Leu Pro  Met Val Ser 
    1835                 1840                 1845             


Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys 
    1850                 1855                 1860             


Arg Val  Leu Gly Glu Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln 
    1865                 1870                 1875             


Met Glu  Glu Arg Phe Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr 
    1880                 1885                 1890             


Glu Pro  Ile Thr Thr Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser 
    1895                 1900                 1905             


Ala Ile  Ile Ile Gln Arg Ala  Tyr Arg Arg Tyr Leu  Leu Lys Gln 
    1910                 1915                 1920             


Lys Val  Lys Lys Val Ser Ser  Ile Tyr Lys Lys Asp  Lys Gly Lys 
    1925                 1930                 1935             


Glu Cys  Asp Gly Thr Pro Ile  Lys Glu Asp Thr Leu  Ile Asp Lys 
    1940                 1945                 1950             


Leu Asn  Glu Asn Ser Thr Pro  Glu Lys Thr Asp Met  Thr Pro Ser 
    1955                 1960                 1965             


Thr Thr  Ser Pro Pro Ser Tyr  Asp Ser Val Thr Lys  Pro Glu Lys 
    1970                 1975                 1980             


Glu Lys  Phe Glu Lys Asp Lys  Ser Glu Lys Glu Asp  Lys Gly Lys 
    1985                 1990                 1995             


Asp Ile  Arg Glu Ser Lys Lys  
    2000                 2005 


<210>  25
<211>  2000
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav1.3 (alpha subunit)

<400>  25

Met Ala Gln Ala Leu Leu Val Pro Pro Gly Pro Glu Ser Phe Arg Leu 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Ala Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Lys Pro Lys Lys Glu Gln Asp Asn Asp Asp Glu Asn Lys 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Met Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Leu Asn Pro Val Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Leu Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Ser Val Ile Val Met Ala Tyr Val Thr Glu Phe Val Ser 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Ser Asp Ser Ala Phe Glu 
        275                 280                 285             


Thr Asn Thr Thr Ser Tyr Phe Asn Gly Thr Met Asp Ser Asn Gly Thr 
    290                 295                 300                 


Phe Val Asn Val Thr Met Ser Thr Phe Asn Trp Lys Asp Tyr Ile Gly 
305                 310                 315                 320 


Asp Asp Ser His Phe Tyr Val Leu Asp Gly Gln Lys Asp Pro Leu Leu 
                325                 330                 335     


Cys Gly Asn Gly Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile Cys 
            340                 345                 350         


Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr 
        355                 360                 365             


Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Tyr 
    370                 375                 380                 


Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr 
385                 390                 395                 400 


Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Val 
                405                 410                 415     


Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln 
            420                 425                 430         


Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met 
        435                 440                 445             


Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Val Ala Ala 
    450                 455                 460                 


Ala Ser Ala Ala Ser Arg Asp Phe Ser Gly Ile Gly Gly Leu Gly Glu 
465                 470                 475                 480 


Leu Leu Glu Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala 
                485                 490                 495     


Lys Glu Trp Arg Asn Arg Arg Lys Lys Arg Arg Gln Arg Glu His Leu 
            500                 505                 510         


Glu Gly Asn Asn Lys Gly Glu Arg Asp Ser Phe Pro Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Val Lys Arg Ser Ser Phe Leu Phe Ser Met Asp Gly Asn 
    530                 535                 540                 


Arg Leu Thr Ser Asp Lys Lys Phe Cys Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Lys Thr Ser 
                565                 570                 575     


Ile Phe Ser Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Ser Glu Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg Asn Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Met Ser Ser Arg Met Val Pro Gly Leu Pro Ala 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Ala Leu Thr Ser Pro Thr Gly Gln Leu Pro Pro 
            660                 665                 670         


Glu Gly Thr Thr Thr Glu Thr Glu Val Arg Lys Arg Arg Leu Ser Ser 
        675                 680                 685             


Tyr Gln Ile Ser Met Glu Met Leu Glu Asp Ser Ser Gly Arg Gln Arg 
    690                 695                 700                 


Ala Val Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu 
705                 710                 715                 720 


Glu Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Arg Phe Ala Asn Val 
                725                 730                 735     


Phe Leu Ile Trp Asp Cys Cys Asp Ala Trp Leu Lys Val Lys His Leu 
            740                 745                 750         


Val Asn Leu Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
        755                 760                 765             


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met 
    770                 775                 780                 


Thr Glu Gln Phe Ser Ser Val Leu Thr Val Gly Asn Leu Val Phe Thr 
785                 790                 795                 800 


Gly Ile Phe Thr Ala Glu Met Val Leu Lys Ile Ile Ala Met Asp Pro 
                805                 810                 815     


Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Ile Ile Val 
            820                 825                 830         


Ser Leu Ser Leu Met Glu Leu Gly Leu Ser Asn Val Glu Gly Leu Ser 
        835                 840                 845             


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
    850                 855                 860                 


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
865                 870                 875                 880 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
                885                 890                 895     


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
            900                 905                 910         


Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp 
        915                 920                 925             


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
    930                 935                 940                 


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys 
945                 950                 955                 960 


Leu Ile Val Phe Met Leu Val Met Val Ile Gly Asn Leu Val Val Leu 
                965                 970                 975     


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
            980                 985                 990         


Ala Ala Thr Asp Asp Asp Asn Glu  Met Asn Asn Leu Gln  Ile Ala Val 
        995                 1000                 1005             


Gly Arg  Met Gln Lys Gly Ile  Asp Tyr Val Lys Asn  Lys Met Arg 
    1010                 1015                 1020             


Glu Cys  Phe Gln Lys Ala Phe  Phe Arg Lys Pro Lys  Val Ile Glu 
    1025                 1030                 1035             


Ile His  Glu Gly Asn Lys Ile  Asp Ser Cys Met Ser  Asn Asn Thr 
    1040                 1045                 1050             


Gly Ile  Glu Ile Ser Lys Glu  Leu Asn Tyr Leu Arg  Asp Gly Asn 
    1055                 1060                 1065             


Gly Thr  Thr Ser Gly Val Gly  Thr Gly Ser Ser Val  Glu Lys Tyr 
    1070                 1075                 1080             


Val Ile  Asp Glu Asn Asp Tyr  Met Ser Phe Ile Asn  Asn Pro Ser 
    1085                 1090                 1095             


Leu Thr  Val Thr Val Pro Ile  Ala Val Gly Glu Ser  Asp Phe Glu 
    1100                 1105                 1110             


Asn Leu  Asn Thr Glu Glu Phe  Ser Ser Glu Ser Glu  Leu Glu Glu 
    1115                 1120                 1125             


Ser Lys  Glu Lys Leu Asn Ala  Thr Ser Ser Ser Glu  Gly Ser Thr 
    1130                 1135                 1140             


Val Asp  Val Val Leu Pro Arg  Glu Gly Glu Gln Ala  Glu Thr Glu 
    1145                 1150                 1155             


Pro Glu  Glu Asp Leu Lys Pro  Glu Ala Cys Phe Thr  Glu Gly Cys 
    1160                 1165                 1170             


Ile Lys  Lys Phe Pro Phe Cys  Gln Val Ser Thr Glu  Glu Gly Lys 
    1175                 1180                 1185             


Gly Lys  Ile Trp Trp Asn Leu  Arg Lys Thr Cys Tyr  Ser Ile Val 
    1190                 1195                 1200             


Glu His  Asn Trp Phe Glu Thr  Phe Ile Val Phe Met  Ile Leu Leu 
    1205                 1210                 1215             


Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile Tyr Ile  Glu Gln Arg 
    1220                 1225                 1230             


Lys Thr  Ile Lys Thr Met Leu  Glu Tyr Ala Asp Lys  Val Phe Thr 
    1235                 1240                 1245             


Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys Trp Val  Ala Tyr Gly 
    1250                 1255                 1260             


Phe Gln  Thr Tyr Phe Thr Asn  Ala Trp Cys Trp Leu  Asp Phe Leu 
    1265                 1270                 1275             


Ile Val  Asp Val Ser Leu Val  Ser Leu Val Ala Asn  Ala Leu Gly 
    1280                 1285                 1290             


Tyr Ser  Glu Leu Gly Ala Ile  Lys Ser Leu Arg Thr  Leu Arg Ala 
    1295                 1300                 1305             


Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe Glu Gly  Met Arg Val 
    1310                 1315                 1320             


Val Val  Asn Ala Leu Val Gly  Ala Ile Pro Ser Ile  Met Asn Val 
    1325                 1330                 1335             


Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile Phe Ser  Ile Met Gly 
    1340                 1345                 1350             


Val Asn  Leu Phe Ala Gly Lys  Phe Tyr His Cys Val  Asn Met Thr 
    1355                 1360                 1365             


Thr Gly  Asn Met Phe Asp Ile  Ser Asp Val Asn Asn  Leu Ser Asp 
    1370                 1375                 1380             


Cys Gln  Ala Leu Gly Lys Gln  Ala Arg Trp Lys Asn  Val Lys Val 
    1385                 1390                 1395             


Asn Phe  Asp Asn Val Gly Ala  Gly Tyr Leu Ala Leu  Leu Gln Val 
    1400                 1405                 1410             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1415                 1420                 1425             


Ser Arg  Asp Val Lys Leu Gln  Pro Val Tyr Glu Glu  Asn Leu Tyr 
    1430                 1435                 1440             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1445                 1450                 1455             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1460                 1465                 1470             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1475                 1480                 1485             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1490                 1495                 1500             


Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn Lys Phe  Gln Gly Met 
    1505                 1510                 1515             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1520                 1525                 1530             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1535                 1540                 1545             


Asp Gln  Gly Lys Tyr Met Thr  Leu Val Leu Ser Arg  Ile Asn Leu 
    1550                 1555                 1560             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Phe Val Leu  Lys Leu Val 
    1565                 1570                 1575             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1580                 1585                 1590             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1595                 1600                 1605             


Met Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1610                 1615                 1620             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1625                 1630                 1635             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1640                 1645                 1650             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1655                 1660                 1665             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Lys Glu 
    1670                 1675                 1680             


Ala Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1685                 1690                 1695             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1700                 1705                 1710             


Leu Leu  Ala Pro Ile Leu Asn  Ser Ala Pro Pro Asp  Cys Asp Pro 
    1715                 1720                 1725             


Asp Thr  Ile His Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1730                 1735                 1740             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1745                 1750                 1755             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1760                 1765                 1770             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1775                 1780                 1785             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1790                 1795                 1800             


Ala Thr  Gln Phe Ile Glu Phe  Ser Lys Leu Ser Asp  Phe Ala Ala 
    1805                 1810                 1815             


Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys Pro Asn  Lys Val Gln 
    1820                 1825                 1830             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1835                 1840                 1845             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1850                 1855                 1860             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Asp Arg Phe 
    1865                 1870                 1875             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Glu Pro  Ile Thr Thr 
    1880                 1885                 1890             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Ala  Ile Ile Gln 
    1895                 1900                 1905             


Arg Asn  Phe Arg Cys Tyr Leu  Leu Lys Gln Arg Leu  Lys Asn Ile 
    1910                 1915                 1920             


Ser Ser  Asn Tyr Asn Lys Glu  Ala Ile Lys Gly Arg  Ile Asp Leu 
    1925                 1930                 1935             


Pro Ile  Lys Gln Asp Met Ile  Ile Asp Lys Leu Asn  Gly Asn Ser 
    1940                 1945                 1950             


Thr Pro  Glu Lys Thr Asp Gly  Ser Ser Ser Thr Thr  Ser Pro Pro 
    1955                 1960                 1965             


Ser Tyr  Asp Ser Val Thr Lys  Pro Asp Lys Glu Lys  Phe Glu Lys 
    1970                 1975                 1980             


Asp Lys  Pro Glu Lys Glu Ser  Lys Gly Lys Glu Val  Arg Glu Asn 
    1985                 1990                 1995             


Gln Lys  
    2000 


<210>  26
<211>  1836
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav1.4 (alpha subunit)

<400>  26

Met Ala Arg Pro Ser Leu Cys Thr Leu Val Pro Leu Gly Pro Glu Cys 
1               5                   10                  15      


Leu Arg Pro Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ala 
            20                  25                  30          


Val Glu Glu Glu Ala Arg Leu Gln Arg Asn Lys Gln Met Glu Ile Glu 
        35                  40                  45              


Glu Pro Glu Arg Lys Pro Arg Ser Asp Leu Glu Ala Gly Lys Asn Leu 
    50                  55                  60                  


Pro Met Ile Tyr Gly Asp Pro Pro Pro Glu Val Ile Gly Ile Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Tyr Tyr Ser Asn Lys Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Ala Ile Phe Arg Phe Ser Ala Thr Pro Ala Leu Tyr 
            100                 105                 110         


Leu Leu Ser Pro Phe Ser Val Val Arg Arg Gly Ala Ile Lys Val Leu 
        115                 120                 125             


Ile His Ala Leu Phe Ser Met Phe Ile Met Ile Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Thr Met Ser Asp Pro Pro Pro Trp Ser Lys Asn Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Val Asp Asp Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr Leu Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Ile Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Thr Val Ile Pro Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Val Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg Gln Lys Cys Val Arg Trp Pro Pro Pro Phe Asn 
        275                 280                 285             


Asp Thr Asn Thr Thr Trp Tyr Ser Asn Asp Thr Trp Tyr Gly Asn Asp 
    290                 295                 300                 


Thr Trp Tyr Gly Asn Glu Met Trp Tyr Gly Asn Asp Ser Trp Tyr Ala 
305                 310                 315                 320 


Asn Asp Thr Trp Asn Ser His Ala Ser Trp Ala Thr Asn Asp Thr Phe 
                325                 330                 335     


Asp Trp Asp Ala Tyr Ile Ser Asp Glu Gly Asn Phe Tyr Phe Leu Glu 
            340                 345                 350         


Gly Ser Asn Asp Ala Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly His 
        355                 360                 365             


Cys Pro Glu Gly Tyr Glu Cys Ile Lys Thr Gly Arg Asn Pro Asn Tyr 
    370                 375                 380                 


Gly Tyr Thr Ser Tyr Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe 
385                 390                 395                 400 


Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Phe Gln Leu Thr Leu 
                405                 410                 415     


Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Ile Ile Phe 
            420                 425                 430         


Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val Ala Met 
        435                 440                 445             


Ala Tyr Ala Glu Gln Asn Glu Ala Thr Leu Ala Glu Asp Lys Glu Lys 
    450                 455                 460                 


Glu Glu Glu Phe Gln Gln Met Leu Glu Lys Phe Lys Lys His Gln Glu 
465                 470                 475                 480 


Glu Leu Glu Lys Ala Lys Ala Ala Gln Ala Leu Glu Gly Gly Glu Ala 
                485                 490                 495     


Asp Gly Asp Pro Ala His Gly Lys Asp Cys Asn Gly Ser Leu Asp Thr 
            500                 505                 510         


Ser Gln Gly Glu Lys Gly Ala Pro Arg Gln Ser Ser Ser Gly Asp Ser 
        515                 520                 525             


Gly Ile Ser Asp Ala Met Glu Glu Leu Glu Glu Ala His Gln Lys Cys 
    530                 535                 540                 


Pro Pro Trp Trp Tyr Lys Cys Ala His Lys Val Leu Ile Trp Asn Cys 
545                 550                 555                 560 


Cys Ala Pro Trp Leu Lys Phe Lys Asn Ile Ile His Leu Ile Val Met 
                565                 570                 575     


Asp Pro Phe Val Asp Leu Gly Ile Thr Ile Cys Ile Val Leu Asn Thr 
            580                 585                 590         


Leu Phe Met Ala Met Glu His Tyr Pro Met Thr Glu His Phe Asp Asn 
        595                 600                 605             


Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu 
    610                 615                 620                 


Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Gln 
625                 630                 635                 640 


Gly Trp Asn Ile Phe Asp Ser Ile Ile Val Thr Leu Ser Leu Val Glu 
                645                 650                 655     


Leu Gly Leu Ala Asn Val Gln Gly Leu Ser Val Leu Arg Ser Phe Arg 
            660                 665                 670         


Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met 
        675                 680                 685             


Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr 
    690                 695                 700                 


Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln 
705                 710                 715                 720 


Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Ala Leu Asp 
                725                 730                 735     


Cys Asn Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu 
            740                 745                 750         


Ile Val Phe Arg Ile Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp 
        755                 760                 765             


Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Leu Met 
    770                 775                 780                 


Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu 
785                 790                 795                 800 


Leu Leu Ser Ser Phe Ser Ala Asp Ser Leu Ala Ala Ser Asp Glu Asp 
                805                 810                 815     


Gly Glu Met Asn Asn Leu Gln Ile Ala Ile Gly Arg Ile Lys Leu Gly 
            820                 825                 830         


Ile Gly Phe Ala Lys Ala Phe Leu Leu Gly Leu Leu His Gly Lys Ile 
        835                 840                 845             


Leu Ser Pro Lys Asp Ile Met Leu Ser Leu Gly Glu Ala Asp Gly Ala 
    850                 855                 860                 


Gly Glu Ala Gly Glu Ala Gly Glu Thr Ala Pro Glu Asp Glu Lys Lys 
865                 870                 875                 880 


Glu Pro Pro Glu Glu Asp Leu Lys Lys Asp Asn His Ile Leu Asn His 
                885                 890                 895     


Met Gly Leu Ala Asp Gly Pro Pro Ser Ser Leu Glu Leu Asp His Leu 
            900                 905                 910         


Asn Phe Ile Asn Asn Pro Tyr Leu Thr Ile Gln Val Pro Ile Ala Ser 
        915                 920                 925             


Glu Glu Ser Asp Leu Glu Met Pro Thr Glu Glu Glu Thr Asp Thr Phe 
    930                 935                 940                 


Ser Glu Pro Glu Asp Ser Lys Lys Pro Pro Gln Pro Leu Tyr Asp Gly 
945                 950                 955                 960 


Asn Ser Ser Val Cys Ser Thr Ala Asp Tyr Lys Pro Pro Glu Glu Asp 
                965                 970                 975     


Pro Glu Glu Gln Ala Glu Glu Asn Pro Glu Gly Glu Gln Pro Glu Glu 
            980                 985                 990         


Cys Phe Thr Glu Ala Cys Val Gln  Arg Trp Pro Cys Leu  Tyr Val Asp 
        995                 1000                 1005             


Ile Ser  Gln Gly Arg Gly Lys  Lys Trp Trp Thr Leu  Arg Arg Ala 
    1010                 1015                 1020             


Cys Phe  Lys Ile Val Glu His  Asn Trp Phe Glu Thr  Phe Ile Val 
    1025                 1030                 1035             


Phe Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1040                 1045                 1050             


Tyr Ile  Glu Gln Arg Arg Val  Ile Arg Thr Ile Leu  Glu Tyr Ala 
    1055                 1060                 1065             


Asp Lys  Val Phe Thr Tyr Ile  Phe Ile Met Glu Met  Leu Leu Lys 
    1070                 1075                 1080             


Trp Val  Ala Tyr Gly Phe Lys  Val Tyr Phe Thr Asn  Ala Trp Cys 
    1085                 1090                 1095             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Ile Ile  Ser Leu Val 
    1100                 1105                 1110             


Ala Asn  Trp Leu Gly Tyr Ser  Glu Leu Gly Pro Ile  Lys Ser Leu 
    1115                 1120                 1125             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1130                 1135                 1140             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Leu Gly  Ala Ile Pro 
    1145                 1150                 1155             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1160                 1165                 1170             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Tyr 
    1175                 1180                 1185             


Cys Ile  Asn Thr Thr Thr Ser  Glu Arg Phe Asp Ile  Ser Glu Val 
    1190                 1195                 1200             


Asn Asn  Lys Ser Glu Cys Glu  Ser Leu Met His Thr  Gly Gln Val 
    1205                 1210                 1215             


Arg Trp  Leu Asn Val Lys Val  Asn Tyr Asp Asn Val  Gly Leu Gly 
    1220                 1225                 1230             


Tyr Leu  Ser Leu Leu Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp 
    1235                 1240                 1245             


Ile Met  Tyr Ala Ala Val Asp  Ser Arg Glu Lys Glu  Glu Gln Pro 
    1250                 1255                 1260             


Gln Tyr  Glu Val Asn Leu Tyr  Met Tyr Leu Tyr Phe  Val Ile Phe 
    1265                 1270                 1275             


Ile Ile  Phe Gly Ser Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val 
    1280                 1285                 1290             


Ile Ile  Asp Asn Phe Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Lys 
    1295                 1300                 1305             


Asp Ile  Phe Met Thr Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met 
    1310                 1315                 1320             


Lys Lys  Leu Gly Ser Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro 
    1325                 1330                 1335             


Gln Asn  Lys Ile Gln Gly Met  Val Tyr Asp Leu Val  Thr Lys Gln 
    1340                 1345                 1350             


Ala Phe  Asp Ile Thr Ile Met  Ile Leu Ile Cys Leu  Asn Met Val 
    1355                 1360                 1365             


Thr Met  Met Val Glu Thr Asp  Asn Gln Ser Gln Leu  Lys Val Asp 
    1370                 1375                 1380             


Ile Leu  Tyr Asn Ile Asn Met  Ile Phe Ile Ile Ile  Phe Thr Gly 
    1385                 1390                 1395             


Glu Cys  Val Leu Lys Met Leu  Ala Leu Arg Gln Tyr  Tyr Phe Thr 
    1400                 1405                 1410             


Val Gly  Trp Asn Ile Phe Asp  Phe Val Val Val Ile  Leu Ser Ile 
    1415                 1420                 1425             


Val Gly  Leu Ala Leu Ser Asp  Leu Ile Gln Lys Tyr  Phe Val Ser 
    1430                 1435                 1440             


Pro Thr  Leu Phe Arg Val Ile  Arg Leu Ala Arg Ile  Gly Arg Val 
    1445                 1450                 1455             


Leu Arg  Leu Ile Arg Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe 
    1460                 1465                 1470             


Ala Leu  Met Met Ser Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu 
    1475                 1480                 1485             


Leu Phe  Leu Val Met Phe Ile  Tyr Ser Ile Phe Gly  Met Ser Asn 
    1490                 1495                 1500             


Phe Ala  Tyr Val Lys Lys Glu  Ser Gly Ile Asp Asp  Met Phe Asn 
    1505                 1510                 1515             


Phe Glu  Thr Phe Gly Asn Ser  Ile Ile Cys Leu Phe  Glu Ile Thr 
    1520                 1525                 1530             


Thr Ser  Ala Gly Trp Asp Gly  Leu Leu Asn Pro Ile  Leu Asn Ser 
    1535                 1540                 1545             


Gly Pro  Pro Asp Cys Asp Pro  Asn Leu Glu Asn Pro  Gly Thr Ser 
    1550                 1555                 1560             


Val Lys  Gly Asp Cys Gly Asn  Pro Ser Ile Gly Ile  Cys Phe Phe 
    1565                 1570                 1575             


Cys Ser  Tyr Ile Ile Ile Ser  Phe Leu Ile Val Val  Asn Met Tyr 
    1580                 1585                 1590             


Ile Ala  Ile Ile Leu Glu Asn  Phe Asn Val Ala Thr  Glu Glu Ser 
    1595                 1600                 1605             


Ser Glu  Pro Leu Gly Glu Asp  Asp Phe Glu Met Phe  Tyr Glu Thr 
    1610                 1615                 1620             


Trp Glu  Lys Phe Asp Pro Asp  Ala Thr Gln Phe Ile  Ala Tyr Ser 
    1625                 1630                 1635             


Arg Leu  Ser Asp Phe Val Asp  Thr Leu Gln Glu Pro  Leu Arg Ile 
    1640                 1645                 1650             


Ala Lys  Pro Asn Lys Ile Lys  Leu Ile Thr Leu Asp  Leu Pro Met 
    1655                 1660                 1665             


Val Pro  Gly Asp Lys Ile His  Cys Leu Asp Ile Leu  Phe Ala Leu 
    1670                 1675                 1680             


Thr Lys  Glu Val Leu Gly Asp  Ser Gly Glu Met Asp  Ala Leu Lys 
    1685                 1690                 1695             


Gln Thr  Met Glu Glu Lys Phe  Met Ala Ala Asn Pro  Ser Lys Val 
    1700                 1705                 1710             


Ser Tyr  Glu Pro Ile Thr Thr  Thr Leu Lys Arg Lys  His Glu Glu 
    1715                 1720                 1725             


Val Cys  Ala Ile Lys Ile Gln  Arg Ala Tyr Arg Arg  His Leu Leu 
    1730                 1735                 1740             


Gln Arg  Ser Met Lys Gln Ala  Ser Tyr Met Tyr Arg  His Ser His 
    1745                 1750                 1755             


Asp Gly  Ser Gly Asp Asp Ala  Pro Glu Lys Glu Gly  Leu Leu Ala 
    1760                 1765                 1770             


Asn Thr  Met Ser Lys Met Tyr  Gly His Glu Asn Gly  Asn Ser Ser 
    1775                 1780                 1785             


Ser Pro  Ser Pro Glu Glu Lys  Gly Glu Ala Gly Asp  Ala Gly Pro 
    1790                 1795                 1800             


Thr Met  Gly Leu Met Pro Ile  Ser Pro Ser Asp Thr  Ala Trp Pro 
    1805                 1810                 1815             


Pro Ala  Pro Pro Pro Gly Gln  Thr Val Arg Pro Gly  Val Lys Glu 
    1820                 1825                 1830             


Ser Leu  Val 
    1835     


<210>  27
<211>  1983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav1.5 (alpha subunit)

<400>  27

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Val Ser Glu 
        195                 200                 205             


Asn Ile Lys Leu Gly Asn Leu Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His Arg Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Glu Ser Gln Pro  Val Ser Gly 
    1070                 1075                 1080             


Gly Pro  Glu Ala Pro Pro Asp  Ser Arg Thr Trp Ser  Gln Val Ser 
    1085                 1090                 1095             


Ala Thr  Ala Ser Ser Glu Ala  Glu Ala Ser Ala Ser  Gln Ala Asp 
    1100                 1105                 1110             


Trp Arg  Gln Gln Trp Lys Ala  Glu Pro Gln Ala Pro  Gly Cys Gly 
    1115                 1120                 1125             


Glu Thr  Pro Glu Asp Ser Cys  Ser Glu Gly Ser Thr  Ala Asp Met 
    1130                 1135                 1140             


Thr Asn  Thr Ala Glu Leu Leu  Glu Gln Ile Pro Asp  Leu Gly Gln 
    1145                 1150                 1155             


Asp Val  Lys Asp Pro Glu Asp  Cys Phe Thr Glu Gly  Cys Val Arg 
    1160                 1165                 1170             


Arg Cys  Pro Cys Cys Ala Val  Asp Thr Thr Gln Ala  Pro Gly Lys 
    1175                 1180                 1185             


Val Trp  Trp Arg Leu Arg Lys  Thr Cys Tyr His Ile  Val Glu His 
    1190                 1195                 1200             


Ser Trp  Phe Glu Thr Phe Ile  Ile Phe Met Ile Leu  Leu Ser Ser 
    1205                 1210                 1215             


Gly Ala  Leu Ala Phe Glu Asp  Ile Tyr Leu Glu Glu  Arg Lys Thr 
    1220                 1225                 1230             


Ile Lys  Val Leu Leu Glu Tyr  Ala Asp Lys Met Phe  Thr Tyr Val 
    1235                 1240                 1245             


Phe Val  Leu Glu Met Leu Leu  Lys Trp Val Ala Tyr  Gly Phe Lys 
    1250                 1255                 1260             


Lys Tyr  Phe Thr Asn Ala Trp  Cys Trp Leu Asp Phe  Leu Ile Val 
    1265                 1270                 1275             


Asp Val  Ser Leu Val Ser Leu  Val Ala Asn Thr Leu  Gly Phe Ala 
    1280                 1285                 1290             


Glu Met  Gly Pro Ile Lys Ser  Leu Arg Thr Leu Arg  Ala Leu Arg 
    1295                 1300                 1305             


Pro Leu  Arg Ala Leu Ser Arg  Phe Glu Gly Met Arg  Val Val Val 
    1310                 1315                 1320             


Asn Ala  Leu Val Gly Ala Ile  Pro Ser Ile Met Asn  Val Leu Leu 
    1325                 1330                 1335             


Val Cys  Leu Ile Phe Trp Leu  Ile Phe Ser Ile Met  Gly Val Asn 
    1340                 1345                 1350             


Leu Phe  Ala Gly Lys Phe Gly  Arg Cys Ile Asn Gln  Thr Glu Gly 
    1355                 1360                 1365             


Asp Leu  Pro Leu Asn Tyr Thr  Ile Val Asn Asn Lys  Ser Gln Cys 
    1370                 1375                 1380             


Glu Ser  Leu Asn Leu Thr Gly  Glu Leu Tyr Trp Thr  Lys Val Lys 
    1385                 1390                 1395             


Val Asn  Phe Asp Asn Val Gly  Ala Gly Tyr Leu Ala  Leu Leu Gln 
    1400                 1405                 1410             


Val Ala  Thr Phe Lys Gly Trp  Met Asp Ile Met Tyr  Ala Ala Val 
    1415                 1420                 1425             


Asp Ser  Arg Gly Tyr Glu Glu  Gln Pro Gln Trp Glu  Tyr Asn Leu 
    1430                 1435                 1440             


Tyr Met  Tyr Ile Tyr Phe Val  Ile Phe Ile Ile Phe  Gly Ser Phe 
    1445                 1450                 1455             


Phe Thr  Leu Asn Leu Phe Ile  Gly Val Ile Ile Asp  Asn Phe Asn 
    1460                 1465                 1470             


Gln Gln  Lys Lys Lys Leu Gly  Gly Gln Asp Ile Phe  Met Thr Glu 
    1475                 1480                 1485             


Glu Gln  Lys Lys Tyr Tyr Asn  Ala Met Lys Lys Leu  Gly Ser Lys 
    1490                 1495                 1500             


Lys Pro  Gln Lys Pro Ile Pro  Arg Pro Leu Asn Lys  Tyr Gln Gly 
    1505                 1510                 1515             


Phe Ile  Phe Asp Ile Val Thr  Lys Gln Ala Phe Asp  Val Thr Ile 
    1520                 1525                 1530             


Met Phe  Leu Ile Cys Leu Asn  Met Val Thr Met Met  Val Glu Thr 
    1535                 1540                 1545             


Asp Asp  Gln Ser Pro Glu Lys  Ile Asn Ile Leu Ala  Lys Ile Asn 
    1550                 1555                 1560             


Leu Leu  Phe Val Ala Ile Phe  Thr Gly Thr Val Leu  Ser Asp Ile 
    1565                 1570                 1575             


Ile Gln  Lys Tyr Phe Phe Ser  Pro Thr Leu Phe Arg  Val Ile Arg 
    1580                 1585                 1590             


Leu Ala  Arg Ile Gly Arg Ile  Leu Arg Leu Ile Arg  Gly Ala Lys 
    1595                 1600                 1605             


Gly Ile  Arg Thr Leu Leu Phe  Ala Leu Met Met Ser  Leu Pro Ala 
    1610                 1615                 1620             


Leu Phe  Asn Ile Gly Leu Leu  Leu Phe Leu Val Met  Phe Ile Tyr 
    1625                 1630                 1635             


Ser Ile  Phe Gly Met Ala Asn  Phe Ala Tyr Val Lys  Trp Glu Ala 
    1640                 1645                 1650             


Gly Ile  Asp Asp Met Phe Asn  Phe Gln Thr Phe Ala  Asn Ser Met 
    1655                 1660                 1665             


Leu Cys  Leu Phe Gln Ile Thr  Thr Ser Ala Gly Trp  Asp Gly Leu 
    1670                 1675                 1680             


Leu Ser  Pro Ile Leu Asn Thr  Gly Pro Pro Tyr Cys  Asp Pro Thr 
    1685                 1690                 1695             


Leu Pro  Asn Ser Asn Gly Ser  Arg Gly Asp Cys Gly  Ser Pro Ala 
    1700                 1705                 1710             


Val Gly  Ile Leu Phe Phe Thr  Thr Tyr Ile Ile Ile  Ser Phe Leu 
    1715                 1720                 1725             


Ile Val  Val Asn Met Tyr Ile  Ala Ile Ile Leu Glu  Asn Phe Ser 
    1730                 1735                 1740             


Val Ala  Thr Glu Glu Ser Thr  Glu Pro Leu Ser Glu  Asp Asp Phe 
    1745                 1750                 1755             


Asp Met  Phe Tyr Glu Ile Trp  Glu Lys Phe Asp Pro  Glu Ala Thr 
    1760                 1765                 1770             


Gln Phe  Ile Glu Tyr Ser Val  Leu Ser Asp Phe Ala  Asp Ala Leu 
    1775                 1780                 1785             


Ser Glu  Pro Leu Arg Ile Ala  Lys Pro Asn Gln Ile  Ser Leu Ile 
    1790                 1795                 1800             


Asn Met  Asp Leu Pro Met Val  Ser Gly Asp Arg Ile  His Cys Met 
    1805                 1810                 1815             


Asp Ile  Leu Phe Ala Phe Thr  Lys Arg Val Leu Gly  Glu Ser Gly 
    1820                 1825                 1830             


Glu Met  Asp Ala Leu Lys Ile  Gln Met Glu Glu Lys  Phe Met Ala 
    1835                 1840                 1845             


Ala Asn  Pro Ser Lys Ile Ser  Tyr Glu Pro Ile Thr  Thr Thr Leu 
    1850                 1855                 1860             


Arg Arg  Lys His Glu Glu Val  Ser Ala Met Val Ile  Gln Arg Ala 
    1865                 1870                 1875             


Phe Arg  Arg His Leu Leu Gln  Arg Ser Leu Lys His  Ala Ser Phe 
    1880                 1885                 1890             


Leu Phe  Arg Gln Gln Ala Gly  Ser Gly Leu Ser Glu  Glu Asp Ala 
    1895                 1900                 1905             


Pro Glu  Arg Glu Gly Leu Ile  Ala Tyr Val Met Ser  Glu Asn Phe 
    1910                 1915                 1920             


Ser Arg  Pro Leu Gly Pro Pro  Ser Ser Ser Ser Ile  Ser Ser Thr 
    1925                 1930                 1935             


Ser Phe  Pro Pro Ser Tyr Asp  Ser Val Thr Arg Ala  Thr Ser Asp 
    1940                 1945                 1950             


Asn Leu  Gln Val Arg Gly Ser  Asp Tyr Ser His Ser  Glu Asp Leu 
    1955                 1960                 1965             


Ala Asp  Phe Pro Pro Ser Pro  Asp Arg Asp Arg Glu  Ser Ile Val 
    1970                 1975                 1980             


<210>  28
<211>  1980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav1.6 (alpha subunit)

<400>  28

Met Ala Ala Arg Leu Leu Ala Pro Pro Gly Pro Asp Ser Phe Lys Pro 
1               5                   10                  15      


Phe Thr Pro Glu Ser Leu Ala Asn Ile Glu Arg Arg Ile Ala Glu Ser 
            20                  25                  30          


Lys Leu Lys Lys Pro Pro Lys Ala Asp Gly Ser His Arg Glu Asp Asp 
        35                  40                  45              


Glu Asp Ser Lys Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser 
    50                  55                  60                  


Leu Pro Phe Ile Tyr Gly Asp Ile Pro Gln Gly Leu Val Ala Val Pro 
65                  70                  75                  80  


Leu Glu Asp Phe Asp Pro Tyr Tyr Leu Thr Gln Lys Thr Phe Val Val 
                85                  90                  95      


Leu Asn Arg Gly Lys Thr Leu Phe Arg Phe Ser Ala Thr Pro Ala Leu 
            100                 105                 110         


Tyr Ile Leu Ser Pro Phe Asn Leu Ile Arg Arg Ile Ala Ile Lys Ile 
        115                 120                 125             


Leu Ile His Ser Val Phe Ser Met Ile Ile Met Cys Thr Ile Leu Thr 
    130                 135                 140                 


Asn Cys Val Phe Met Thr Phe Ser Asn Pro Pro Asp Trp Ser Lys Asn 
145                 150                 155                 160 


Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys 
                165                 170                 175     


Ile Ile Ala Arg Gly Phe Cys Ile Asp Gly Phe Thr Phe Leu Arg Asp 
            180                 185                 190         


Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr Ile Thr 
        195                 200                 205             


Glu Phe Val Asn Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val 
    210                 215                 220                 


Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile 
225                 230                 235                 240 


Val Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile 
                245                 250                 255     


Leu Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu 
            260                 265                 270         


Phe Met Gly Asn Leu Arg Asn Lys Cys Val Val Trp Pro Ile Asn Phe 
        275                 280                 285             


Asn Glu Ser Tyr Leu Glu Asn Gly Thr Lys Gly Phe Asp Trp Glu Glu 
    290                 295                 300                 


Tyr Ile Asn Asn Lys Thr Asn Phe Tyr Thr Val Pro Gly Met Leu Glu 
305                 310                 315                 320 


Pro Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly 
                325                 330                 335     


Tyr Gln Cys Met Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser 
            340                 345                 350         


Phe Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe Arg Leu Met Thr 
        355                 360                 365             


Gln Asp Tyr Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly 
    370                 375                 380                 


Lys Thr Tyr Met Ile Phe Phe Val Leu Val Ile Phe Val Gly Ser Phe 
385                 390                 395                 400 


Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu 
                405                 410                 415     


Gln Asn Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe 
            420                 425                 430         


Lys Ala Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala 
        435                 440                 445             


Ala Ala Met Ala Thr Ser Ala Gly Thr Val Ser Glu Asp Ala Ile Glu 
    450                 455                 460                 


Glu Glu Gly Glu Glu Gly Gly Gly Ser Pro Arg Ser Ser Ser Glu Ile 
465                 470                 475                 480 


Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Lys 
                485                 490                 495     


Lys Arg Lys Gln Lys Glu Leu Ser Glu Gly Glu Glu Lys Gly Asp Pro 
            500                 505                 510         


Glu Lys Val Phe Lys Ser Glu Ser Glu Asp Gly Met Arg Arg Lys Ala 
        515                 520                 525             


Phe Arg Leu Pro Asp Asn Arg Ile Gly Arg Lys Phe Ser Ile Met Asn 
    530                 535                 540                 


Gln Ser Leu Leu Ser Ile Pro Gly Ser Pro Phe Leu Ser Arg His Asn 
545                 550                 555                 560 


Ser Lys Ser Ser Ile Phe Ser Phe Arg Gly Pro Gly Arg Phe Arg Asp 
                565                 570                 575     


Pro Gly Ser Glu Asn Glu Phe Ala Asp Asp Glu His Ser Thr Val Glu 
            580                 585                 590         


Glu Ser Glu Gly Arg Arg Asp Ser Leu Phe Ile Pro Ile Arg Ala Arg 
        595                 600                 605             


Glu Arg Arg Ser Ser Tyr Ser Gly Tyr Ser Gly Tyr Ser Gln Gly Ser 
    610                 615                 620                 


Arg Ser Ser Arg Ile Phe Pro Ser Leu Arg Arg Ser Val Lys Arg Asn 
625                 630                 635                 640 


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Ile Gly Gly Pro Gly 
                645                 650                 655     


Ser His Ile Gly Gly Arg Leu Leu Pro Glu Ala Thr Thr Glu Val Glu 
            660                 665                 670         


Ile Lys Lys Lys Gly Pro Gly Ser Leu Leu Val Ser Met Asp Gln Leu 
        675                 680                 685             


Ala Ser Tyr Gly Arg Lys Asp Arg Ile Asn Ser Ile Met Ser Val Val 
    690                 695                 700                 


Thr Asn Thr Leu Val Glu Glu Leu Glu Glu Ser Gln Arg Lys Cys Pro 
705                 710                 715                 720 


Pro Cys Trp Tyr Lys Phe Ala Asn Thr Phe Leu Ile Trp Glu Cys His 
                725                 730                 735     


Pro Tyr Trp Ile Lys Leu Lys Glu Ile Val Asn Leu Ile Val Met Asp 
            740                 745                 750         


Pro Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu 
        755                 760                 765             


Phe Met Ala Met Glu His His Pro Met Thr Pro Gln Phe Glu His Val 
    770                 775                 780                 


Leu Ala Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met 
785                 790                 795                 800 


Phe Leu Lys Leu Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly 
                805                 810                 815     


Trp Asn Ile Phe Asp Gly Phe Ile Val Ser Leu Ser Leu Met Glu Leu 
            820                 825                 830         


Ser Leu Ala Asp Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu 
        835                 840                 845             


Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu 
    850                 855                 860                 


Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu 
865                 870                 875                 880 


Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu 
                885                 890                 895     


Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Asn Gln Asp Cys 
            900                 905                 910         


Glu Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu Ile 
        915                 920                 925             


Val Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys 
    930                 935                 940                 


Met Glu Val Ala Gly Gln Ala Met Cys Leu Ile Val Phe Met Met Val 
945                 950                 955                 960 


Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu 
                965                 970                 975     


Leu Ser Ser Phe Ser Ala Asp Asn Leu Ala Ala Thr Asp Asp Asp Gly 
            980                 985                 990         


Glu Met Asn Asn Leu Gln Ile Ser  Val Ile Arg Ile Lys  Lys Gly Val 
        995                 1000                 1005             


Ala Trp  Thr Lys Leu Lys Val  His Ala Phe Met Gln  Ala His Phe 
    1010                 1015                 1020             


Lys Gln  Arg Glu Ala Asp Glu  Val Lys Pro Leu Asp  Glu Leu Tyr 
    1025                 1030                 1035             


Glu Lys  Lys Ala Asn Cys Ile  Ala Asn His Thr Gly  Ala Asp Ile 
    1040                 1045                 1050             


His Arg  Asn Gly Asp Phe Gln  Lys Asn Gly Asn Gly  Thr Thr Ser 
    1055                 1060                 1065             


Gly Ile  Gly Ser Ser Val Glu  Lys Tyr Ile Ile Asp  Glu Asp His 
    1070                 1075                 1080             


Met Ser  Phe Ile Asn Asn Pro  Asn Leu Thr Val Arg  Val Pro Ile 
    1085                 1090                 1095             


Ala Val  Gly Glu Ser Asp Phe  Glu Asn Leu Asn Thr  Glu Asp Val 
    1100                 1105                 1110             


Ser Ser  Glu Ser Asp Pro Glu  Gly Ser Lys Asp Lys  Leu Asp Asp 
    1115                 1120                 1125             


Thr Ser  Ser Ser Glu Gly Ser  Thr Ile Asp Ile Lys  Pro Glu Val 
    1130                 1135                 1140             


Glu Glu  Val Pro Val Glu Gln  Pro Glu Glu Tyr Leu  Asp Pro Asp 
    1145                 1150                 1155             


Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg Phe Lys  Cys Cys Gln 
    1160                 1165                 1170             


Val Asn  Ile Glu Glu Gly Leu  Gly Lys Ser Trp Trp  Ile Leu Arg 
    1175                 1180                 1185             


Lys Thr  Cys Phe Leu Ile Val  Glu His Asn Trp Phe  Glu Thr Phe 
    1190                 1195                 1200             


Ile Ile  Phe Met Ile Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu 
    1205                 1210                 1215             


Asp Ile  Tyr Ile Glu Gln Arg  Lys Thr Ile Arg Thr  Ile Leu Glu 
    1220                 1225                 1230             


Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu 
    1235                 1240                 1245             


Leu Lys  Trp Thr Ala Tyr Gly  Phe Val Lys Phe Phe  Thr Asn Ala 
    1250                 1255                 1260             


Trp Cys  Trp Leu Asp Phe Leu  Ile Val Ala Val Ser  Leu Val Ser 
    1265                 1270                 1275             


Leu Ile  Ala Asn Ala Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys 
    1280                 1285                 1290             


Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser 
    1295                 1300                 1305             


Arg Phe  Glu Gly Met Arg Val  Val Val Asn Ala Leu  Val Gly Ala 
    1310                 1315                 1320             


Ile Pro  Ser Ile Met Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp 
    1325                 1330                 1335             


Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu Phe Ala  Gly Lys Tyr 
    1340                 1345                 1350             


His Tyr  Cys Phe Asn Glu Thr  Ser Glu Ile Arg Phe  Glu Ile Glu 
    1355                 1360                 1365             


Asp Val  Asn Asn Lys Thr Glu  Cys Glu Lys Leu Met  Glu Gly Asn 
    1370                 1375                 1380             


Asn Thr  Glu Ile Arg Trp Lys  Asn Val Lys Ile Asn  Phe Asp Asn 
    1385                 1390                 1395             


Val Gly  Ala Gly Tyr Leu Ala  Leu Leu Gln Val Ala  Thr Phe Lys 
    1400                 1405                 1410             


Gly Trp  Met Asp Ile Met Tyr  Ala Ala Val Asp Ser  Arg Lys Pro 
    1415                 1420                 1425             


Asp Glu  Gln Pro Lys Tyr Glu  Asp Asn Ile Tyr Met  Tyr Ile Tyr 
    1430                 1435                 1440             


Phe Val  Ile Phe Ile Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu 
    1445                 1450                 1455             


Phe Ile  Gly Val Ile Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys 
    1460                 1465                 1470             


Phe Gly  Gly Gln Asp Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr 
    1475                 1480                 1485             


Tyr Asn  Ala Met Lys Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro 
    1490                 1495                 1500             


Ile Pro  Arg Pro Leu Asn Lys  Ile Gln Gly Ile Val  Phe Asp Phe 
    1505                 1510                 1515             


Val Thr  Gln Gln Ala Phe Asp  Ile Val Ile Met Met  Leu Ile Cys 
    1520                 1525                 1530             


Leu Asn  Met Val Thr Met Met  Val Glu Thr Asp Thr  Gln Ser Lys 
    1535                 1540                 1545             


Gln Met  Glu Asn Ile Leu Tyr  Trp Ile Asn Leu Val  Phe Val Ile 
    1550                 1555                 1560             


Phe Phe  Thr Cys Glu Cys Val  Leu Lys Met Phe Ala  Leu Arg His 
    1565                 1570                 1575             


Tyr Tyr  Phe Thr Ile Gly Trp  Asn Ile Phe Asp Phe  Val Val Val 
    1580                 1585                 1590             


Ile Leu  Ser Ile Val Gly Met  Phe Leu Ala Asp Ile  Ile Glu Lys 
    1595                 1600                 1605             


Tyr Phe  Val Ser Pro Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg 
    1610                 1615                 1620             


Ile Gly  Arg Ile Leu Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg 
    1625                 1630                 1635             


Thr Leu  Leu Phe Ala Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn 
    1640                 1645                 1650             


Ile Gly  Leu Leu Leu Phe Leu  Val Met Phe Ile Phe  Ser Ile Phe 
    1655                 1660                 1665             


Gly Met  Ser Asn Phe Ala Tyr  Val Lys His Glu Ala  Gly Ile Asp 
    1670                 1675                 1680             


Asp Met  Phe Asn Phe Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu 
    1685                 1690                 1695             


Phe Gln  Ile Thr Thr Ser Ala  Gly Trp Asp Gly Leu  Leu Leu Pro 
    1700                 1705                 1710             


Ile Leu  Asn Arg Pro Pro Asp  Cys Ser Leu Asp Lys  Glu His Pro 
    1715                 1720                 1725             


Gly Ser  Gly Phe Lys Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile 
    1730                 1735                 1740             


Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser Phe Leu  Ile Val Val 
    1745                 1750                 1755             


Asn Met  Tyr Ile Ala Ile Ile  Leu Glu Asn Phe Ser  Val Ala Thr 
    1760                 1765                 1770             


Glu Glu  Ser Ala Asp Pro Leu  Ser Glu Asp Asp Phe  Glu Thr Phe 
    1775                 1780                 1785             


Tyr Glu  Ile Trp Glu Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile 
    1790                 1795                 1800             


Glu Tyr  Cys Lys Leu Ala Asp  Phe Ala Asp Ala Leu  Glu His Pro 
    1805                 1810                 1815             


Leu Arg  Val Pro Lys Pro Asn  Thr Ile Glu Leu Ile  Ala Met Asp 
    1820                 1825                 1830             


Leu Pro  Met Val Ser Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu 
    1835                 1840                 1845             


Phe Ala  Phe Thr Lys Arg Val  Leu Gly Asp Ser Gly  Glu Leu Asp 
    1850                 1855                 1860             


Ile Leu  Arg Gln Gln Met Glu  Glu Arg Phe Val Ala  Ser Asn Pro 
    1865                 1870                 1875             


Ser Lys  Val Ser Tyr Glu Pro  Ile Thr Thr Thr Leu  Arg Arg Lys 
    1880                 1885                 1890             


Gln Glu  Glu Val Ser Ala Val  Val Leu Gln Arg Ala  Tyr Arg Gly 
    1895                 1900                 1905             


His Leu  Ala Arg Arg Gly Phe  Ile Cys Lys Lys Thr  Thr Ser Asn 
    1910                 1915                 1920             


Lys Leu  Glu Asn Gly Gly Thr  His Arg Glu Lys Lys  Glu Ser Thr 
    1925                 1930                 1935             


Pro Ser  Thr Ala Ser Leu Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Glu Lys  Glu Lys Gln Gln Arg  Ala Glu Glu Gly Arg  Arg Glu Arg 
    1955                 1960                 1965             


Ala Lys  Arg Gln Lys Glu Val  Arg Glu Ser Lys Cys  
    1970                 1975                 1980 


<210>  29
<211>  1956
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav1.8 (alpha subunit)

<400>  29

Met Glu Phe Pro Ile Gly Ser Leu Glu Thr Asn Asn Phe Arg Arg Phe 
1               5                   10                  15      


Thr Pro Glu Ser Leu Val Glu Ile Glu Lys Gln Ile Ala Ala Lys Gln 
            20                  25                  30          


Gly Thr Lys Lys Ala Arg Glu Lys His Arg Glu Gln Lys Asp Gln Glu 
        35                  40                  45              


Glu Lys Pro Arg Pro Gln Leu Asp Leu Lys Ala Cys Asn Gln Leu Pro 
    50                  55                  60                  


Lys Phe Tyr Gly Glu Leu Pro Ala Glu Leu Ile Gly Glu Pro Leu Glu 
65                  70                  75                  80  


Asp Leu Asp Pro Phe Tyr Ser Thr His Arg Thr Phe Met Val Leu Asn 
                85                  90                  95      


Lys Gly Arg Thr Ile Ser Arg Phe Ser Ala Thr Arg Ala Leu Trp Leu 
            100                 105                 110         


Phe Ser Pro Phe Asn Leu Ile Arg Arg Thr Ala Ile Lys Val Ser Val 
        115                 120                 125             


His Ser Trp Phe Ser Leu Phe Ile Thr Val Thr Ile Leu Val Asn Cys 
    130                 135                 140                 


Val Cys Met Thr Arg Thr Asp Leu Pro Glu Lys Ile Glu Tyr Val Phe 
145                 150                 155                 160 


Thr Val Ile Tyr Thr Phe Glu Ala Leu Ile Lys Ile Leu Ala Arg Gly 
                165                 170                 175     


Phe Cys Leu Asn Glu Phe Thr Tyr Leu Arg Asp Pro Trp Asn Trp Leu 
            180                 185                 190         


Asp Phe Ser Val Ile Thr Leu Ala Tyr Val Gly Thr Ala Ile Asp Leu 
        195                 200                 205             


Arg Gly Ile Ser Gly Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys 
    210                 215                 220                 


Thr Val Ser Val Ile Pro Gly Leu Lys Val Ile Val Gly Ala Leu Ile 
225                 230                 235                 240 


His Ser Val Lys Lys Leu Ala Asp Val Thr Ile Leu Thr Ile Phe Cys 
                245                 250                 255     


Leu Ser Val Phe Ala Leu Val Gly Leu Gln Leu Phe Lys Gly Asn Leu 
            260                 265                 270         


Lys Asn Lys Cys Val Lys Asn Asp Met Ala Val Asn Glu Thr Thr Asn 
        275                 280                 285             


Tyr Ser Ser His Arg Lys Pro Asp Ile Tyr Ile Asn Lys Arg Gly Thr 
    290                 295                 300                 


Ser Asp Pro Leu Leu Cys Gly Asn Gly Ser Asp Ser Gly His Cys Pro 
305                 310                 315                 320 


Asp Gly Tyr Ile Cys Leu Lys Thr Ser Asp Asn Pro Asp Phe Asn Tyr 
                325                 330                 335     


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ser Leu Phe Arg Leu 
            340                 345                 350         


Met Thr Gln Asp Ser Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Thr 
        355                 360                 365             


Ser Gly Lys Ile Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly 
    370                 375                 380                 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Thr Met Ala Tyr 
385                 390                 395                 400 


Glu Glu Gln Asn Gln Ala Thr Thr Asp Glu Ile Glu Ala Lys Glu Lys 
                405                 410                 415     


Lys Phe Gln Glu Ala Leu Glu Met Leu Arg Lys Glu Gln Glu Val Leu 
            420                 425                 430         


Ala Ala Leu Gly Ile Asp Thr Thr Ser Leu His Ser His Asn Gly Ser 
        435                 440                 445             


Pro Leu Thr Ser Lys Asn Ala Ser Glu Arg Arg His Arg Ile Lys Pro 
    450                 455                 460                 


Arg Val Ser Glu Gly Ser Thr Glu Asp Asn Lys Ser Pro Arg Ser Asp 
465                 470                 475                 480 


Pro Tyr Asn Gln Arg Arg Met Ser Phe Leu Gly Leu Ala Ser Gly Lys 
                485                 490                 495     


Arg Arg Ala Ser His Gly Ser Val Phe His Phe Arg Ser Pro Gly Arg 
            500                 505                 510         


Asp Ile Ser Leu Pro Glu Gly Val Thr Asp Asp Gly Val Phe Pro Gly 
        515                 520                 525             


Asp His Glu Ser His Arg Gly Ser Leu Leu Leu Gly Gly Gly Ala Gly 
    530                 535                 540                 


Gln Gln Gly Pro Leu Pro Arg Ser Pro Leu Pro Gln Pro Ser Asn Pro 
545                 550                 555                 560 


Asp Ser Arg His Gly Glu Asp Glu His Gln Pro Pro Pro Thr Ser Glu 
                565                 570                 575     


Leu Ala Pro Gly Ala Val Asp Val Ser Ala Phe Asp Ala Gly Gln Lys 
            580                 585                 590         


Lys Thr Phe Leu Ser Ala Glu Tyr Leu Asp Glu Pro Phe Arg Ala Gln 
        595                 600                 605             


Arg Ala Met Ser Val Val Ser Ile Ile Thr Ser Val Leu Glu Glu Leu 
    610                 615                 620                 


Glu Glu Ser Glu Gln Lys Cys Pro Pro Cys Leu Thr Ser Leu Ser Gln 
625                 630                 635                 640 


Lys Tyr Leu Ile Trp Asp Cys Cys Pro Met Trp Val Lys Leu Lys Thr 
                645                 650                 655     


Ile Leu Phe Gly Leu Val Thr Asp Pro Phe Ala Glu Leu Thr Ile Thr 
            660                 665                 670         


Leu Cys Ile Val Val Asn Thr Ile Phe Met Ala Met Glu His His Gly 
        675                 680                 685             


Met Ser Pro Thr Phe Glu Ala Met Leu Gln Ile Gly Asn Ile Val Phe 
    690                 695                 700                 


Thr Ile Phe Phe Thr Ala Glu Met Val Phe Lys Ile Ile Ala Phe Asp 
705                 710                 715                 720 


Pro Tyr Tyr Tyr Phe Gln Lys Lys Trp Asn Ile Phe Asp Cys Ile Ile 
                725                 730                 735     


Val Thr Val Ser Leu Leu Glu Leu Gly Val Ala Lys Lys Gly Ser Leu 
            740                 745                 750         


Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys 
        755                 760                 765             


Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile Gly Asn Ser Val 
    770                 775                 780                 


Gly Ala Leu Gly Asn Leu Thr Ile Ile Leu Ala Ile Ile Val Phe Val 
785                 790                 795                 800 


Phe Ala Leu Val Gly Lys Gln Leu Leu Gly Glu Asn Tyr Arg Asn Asn 
                805                 810                 815     


Arg Lys Asn Ile Ser Ala Pro His Glu Asp Trp Pro Arg Trp His Met 
            820                 825                 830         


His Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Ile Leu Cys Gly 
        835                 840                 845             


Glu Trp Ile Glu Asn Met Trp Ala Cys Met Glu Val Gly Gln Lys Ser 
    850                 855                 860                 


Ile Cys Leu Ile Leu Phe Leu Thr Val Met Val Leu Gly Asn Leu Val 
865                 870                 875                 880 


Val Leu Asn Leu Phe Ile Ala Leu Leu Leu Asn Ser Phe Ser Ala Asp 
                885                 890                 895     


Asn Leu Thr Ala Pro Glu Asp Asp Gly Glu Val Asn Asn Leu Gln Val 
            900                 905                 910         


Ala Leu Ala Arg Ile Gln Val Phe Gly His Arg Thr Lys Gln Ala Leu 
        915                 920                 925             


Cys Ser Phe Phe Ser Arg Ser Cys Pro Phe Pro Gln Pro Lys Ala Glu 
    930                 935                 940                 


Pro Glu Leu Val Val Lys Leu Pro Leu Ser Ser Ser Lys Ala Glu Asn 
945                 950                 955                 960 


His Ile Ala Ala Asn Thr Ala Arg Gly Ser Ser Gly Gly Leu Gln Ala 
                965                 970                 975     


Pro Arg Gly Pro Arg Asp Glu His Ser Asp Phe Ile Ala Asn Pro Thr 
            980                 985                 990         


Val Trp Val Ser Val Pro Ile Ala  Glu Gly Glu Ser Asp  Leu Asp Asp 
        995                 1000                 1005             


Leu Glu  Asp Asp Gly Gly Glu  Asp Ala Gln Ser Phe  Gln Gln Glu 
    1010                 1015                 1020             


Val Ile  Pro Lys Gly Gln Gln  Glu Gln Leu Gln Gln  Val Glu Arg 
    1025                 1030                 1035             


Cys Gly  Asp His Leu Thr Pro  Arg Ser Pro Gly Thr  Gly Thr Ser 
    1040                 1045                 1050             


Ser Glu  Asp Leu Ala Pro Ser  Leu Gly Glu Thr Trp  Lys Asp Glu 
    1055                 1060                 1065             


Ser Val  Pro Gln Val Pro Ala  Glu Gly Val Asp Asp  Thr Ser Ser 
    1070                 1075                 1080             


Ser Glu  Gly Ser Thr Val Asp  Cys Leu Asp Pro Glu  Glu Ile Leu 
    1085                 1090                 1095             


Arg Lys  Ile Pro Glu Leu Ala  Asp Asp Leu Glu Glu  Pro Asp Asp 
    1100                 1105                 1110             


Cys Phe  Thr Glu Gly Cys Ile  Arg His Cys Pro Cys  Cys Lys Leu 
    1115                 1120                 1125             


Asp Thr  Thr Lys Ser Pro Trp  Asp Val Gly Trp Gln  Val Arg Lys 
    1130                 1135                 1140             


Thr Cys  Tyr Arg Ile Val Glu  His Ser Trp Phe Glu  Ser Phe Ile 
    1145                 1150                 1155             


Ile Phe  Met Ile Leu Leu Ser  Ser Gly Ser Leu Ala  Phe Glu Asp 
    1160                 1165                 1170             


Tyr Tyr  Leu Asp Gln Lys Pro  Thr Val Lys Ala Leu  Leu Glu Tyr 
    1175                 1180                 1185             


Thr Asp  Arg Val Phe Thr Phe  Ile Phe Val Phe Glu  Met Leu Leu 
    1190                 1195                 1200             


Lys Trp  Val Ala Tyr Gly Phe  Lys Lys Tyr Phe Thr  Asn Ala Trp 
    1205                 1210                 1215             


Cys Trp  Leu Asp Phe Leu Ile  Val Asn Ile Ser Leu  Ile Ser Leu 
    1220                 1225                 1230             


Thr Ala  Lys Ile Leu Glu Tyr  Ser Glu Val Ala Pro  Ile Lys Ala 
    1235                 1240                 1245             


Leu Arg  Thr Leu Arg Ala Leu  Arg Pro Leu Arg Ala  Leu Ser Arg 
    1250                 1255                 1260             


Phe Glu  Gly Met Arg Val Val  Val Asp Ala Leu Val  Gly Ala Ile 
    1265                 1270                 1275             


Pro Ser  Ile Met Asn Val Leu  Leu Val Cys Leu Ile  Phe Trp Leu 
    1280                 1285                 1290             


Ile Phe  Ser Ile Met Gly Val  Asn Leu Phe Ala Gly  Lys Phe Trp 
    1295                 1300                 1305             


Arg Cys  Ile Asn Tyr Thr Asp  Gly Glu Phe Ser Leu  Val Pro Leu 
    1310                 1315                 1320             


Ser Ile  Val Asn Asn Lys Ser  Asp Cys Lys Ile Gln  Asn Ser Thr 
    1325                 1330                 1335             


Gly Ser  Phe Phe Trp Val Asn  Val Lys Val Asn Phe  Asp Asn Val 
    1340                 1345                 1350             


Ala Met  Gly Tyr Leu Ala Leu  Leu Gln Val Ala Thr  Phe Lys Gly 
    1355                 1360                 1365             


Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp Ser Arg  Glu Val Asn 
    1370                 1375                 1380             


Met Gln  Pro Lys Trp Glu Asp  Asn Val Tyr Met Tyr  Leu Tyr Phe 
    1385                 1390                 1395             


Val Ile  Phe Ile Ile Phe Gly  Gly Phe Phe Thr Leu  Asn Leu Phe 
    1400                 1405                 1410             


Val Gly  Val Ile Ile Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Leu 
    1415                 1420                 1425             


Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr 
    1430                 1435                 1440             


Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile 
    1445                 1450                 1455             


Pro Arg  Pro Leu Asn Lys Phe  Gln Gly Phe Val Phe  Asp Ile Val 
    1460                 1465                 1470             


Thr Arg  Gln Ala Phe Asp Ile  Thr Ile Met Val Leu  Ile Cys Leu 
    1475                 1480                 1485             


Asn Met  Ile Thr Met Met Val  Glu Thr Asp Asp Gln  Ser Glu Glu 
    1490                 1495                 1500             


Lys Thr  Lys Ile Leu Gly Lys  Ile Asn Gln Phe Phe  Val Ala Val 
    1505                 1510                 1515             


Phe Thr  Gly Glu Cys Val Met  Lys Met Phe Ala Leu  Arg Gln Tyr 
    1520                 1525                 1530             


Tyr Phe  Thr Asn Gly Trp Asn  Val Phe Asp Phe Ile  Val Val Val 
    1535                 1540                 1545             


Leu Ser  Ile Ala Ser Leu Ile  Phe Ser Ala Ile Leu  Lys Ser Leu 
    1550                 1555                 1560             


Gln Ser  Tyr Phe Ser Pro Thr  Leu Phe Arg Val Ile  Arg Leu Ala 
    1565                 1570                 1575             


Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Arg Ala Ala  Lys Gly Ile 
    1580                 1585                 1590             


Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser Leu Pro  Ala Leu Phe 
    1595                 1600                 1605             


Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met Phe Ile  Tyr Ser Ile 
    1610                 1615                 1620             


Phe Gly  Met Ser Ser Phe Pro  His Val Arg Trp Glu  Ala Gly Ile 
    1625                 1630                 1635             


Asp Asp  Met Phe Asn Phe Gln  Thr Phe Ala Asn Ser  Met Leu Cys 
    1640                 1645                 1650             


Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp Asp Gly  Leu Leu Ser 
    1655                 1660                 1665             


Pro Ile  Leu Asn Thr Gly Pro  Pro Tyr Cys Asp Pro  Asn Leu Pro 
    1670                 1675                 1680             


Asn Ser  Asn Gly Thr Arg Gly  Asp Cys Gly Ser Pro  Ala Val Gly 
    1685                 1690                 1695             


Ile Ile  Phe Phe Thr Thr Tyr  Ile Ile Ile Ser Phe  Leu Ile Met 
    1700                 1705                 1710             


Val Asn  Met Tyr Ile Ala Val  Ile Leu Glu Asn Phe  Asn Val Ala 
    1715                 1720                 1725             


Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu Asp Asp  Phe Asp Met 
    1730                 1735                 1740             


Phe Tyr  Glu Thr Trp Glu Lys  Phe Asp Pro Glu Ala  Thr Gln Phe 
    1745                 1750                 1755             


Ile Thr  Phe Ser Ala Leu Ser  Asp Phe Ala Asp Thr  Leu Ser Gly 
    1760                 1765                 1770             


Pro Leu  Arg Ile Pro Lys Pro  Asn Arg Asn Ile Leu  Ile Gln Met 
    1775                 1780                 1785             


Asp Leu  Pro Leu Val Pro Gly  Asp Lys Ile His Cys  Leu Asp Ile 
    1790                 1795                 1800             


Leu Phe  Ala Phe Thr Lys Asn  Val Leu Gly Glu Ser  Gly Glu Leu 
    1805                 1810                 1815             


Asp Ser  Leu Lys Ala Asn Met  Glu Glu Lys Phe Met  Ala Thr Asn 
    1820                 1825                 1830             


Leu Ser  Lys Ser Ser Tyr Glu  Pro Ile Ala Thr Thr  Leu Arg Trp 
    1835                 1840                 1845             


Lys Gln  Glu Asp Ile Ser Ala  Thr Val Ile Gln Lys  Ala Tyr Arg 
    1850                 1855                 1860             


Ser Tyr  Val Leu His Arg Ser  Met Ala Leu Ser Asn  Thr Pro Cys 
    1865                 1870                 1875             


Val Pro  Arg Ala Glu Glu Glu  Ala Ala Ser Leu Pro  Asp Glu Gly 
    1880                 1885                 1890             


Phe Val  Ala Phe Thr Ala Asn  Glu Asn Cys Val Leu  Pro Asp Lys 
    1895                 1900                 1905             


Ser Glu  Thr Ala Ser Ala Thr  Ser Phe Pro Pro Ser  Tyr Glu Ser 
    1910                 1915                 1920             


Val Thr  Arg Gly Leu Ser Asp  Arg Val Asn Met Arg  Thr Ser Ser 
    1925                 1930                 1935             


Ser Ile  Gln Asn Glu Asp Glu  Ala Thr Ser Met Glu  Leu Ile Ala 
    1940                 1945                 1950             


Pro Gly  Pro 
    1955     


<210>  30
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103262B06 (parental)-FLAG-HIS6

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Thr Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu Phe Val 
        35                  40                  45              


Ala His Ile Asn Phe Ser Gly Ser Ser Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Trp Val Ala Gly Pro Pro Arg Tyr Asp Tyr Glu Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys 
        115                 120                 125             


Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp 
    130                 135                 140                 


Asp Asp Lys Gly Ala Ala His His His His His His 
145                 150                 155     


<210>  31
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103262C02 (parental)-FLAG-HIS6

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Leu Pro Phe Gly Leu Tyr 
            20                  25                  30          


Ile Leu Gly Trp Ile Arg Arg Ala Pro Gly Lys Glu Arg Asp Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Arg Asp Thr Val Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Arg Met Asp Asn Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Val Asp Ser Val Pro Arg Gly Thr Pro Thr Ile Thr Glu Ser Glu 
            100                 105                 110         


Tyr Ala Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala 
        115                 120                 125             


Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
    130                 135                 140                 


Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His His His 
145                 150                 155                 160 


<210>  32
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103265A11 (parental)-FLAG-HIS6

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Ala Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Tyr Thr Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ser 
                85                  90                  95      


Leu Ser Arg Tyr Leu Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile 
        115                 120                 125             


Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His His 
    130                 135                 140                 


His 
145 


<210>  33
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103265B04 (parental)-FLAG-HIS6

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Ser Phe Ile Phe Ser Asn Asn 
            20                  25                  30          


Tyr Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Trp Val 
        35                  40                  45              


Ala Arg Ile Thr Gly Arg Gly Asn Thr Asn Tyr Leu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Glu Ile Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ala Leu Trp Tyr Gly Gly Arg Ala Trp Gly Lys Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys 
        115                 120                 125             


Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His 
    130                 135                 140                 


His His His His His 
145                 


<210>  34
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103275B05 (parental)-FLAG-HIS6

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His 
        115                 120                 125             


Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp 
    130                 135                 140                 


Lys Gly Ala Ala His His His His His His 
145                 150                 


<210>  35
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103362B08 (parental)-FLAG-HIS6

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
    130                 135                 140                 


Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His His His 
145                 150                 155                 


<210>  36
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G04 (parental)-FLAG-HIS6

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Lys Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Val Thr Pro Thr Gly Ser Ile Ser Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Arg Trp Ser Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His 
        115                 120                 125             


Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp 
    130                 135                 140                 


Lys Gly Ala Ala His His His His His His 
145                 150                 


<210>  37
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G05 (parental)-FLAG-HIS6

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp 
        115                 120                 125             


Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys 
    130                 135                 140                 


Asp Asp Asp Asp Lys Gly Ala Ala His His His His His His 
145                 150                 155             


<210>  38
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103454D07 (parental)-FLAG-HIS6

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Gly Ile Ile Asn Ile Asn 
            20                  25                  30          


Tyr Ile Ala Trp Tyr Arg Gln Thr Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Arg Ile Ser Ser Asp Asp Thr Ile Lys Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Met Ser Arg Asp Lys Val Lys Asn Met Val His Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Thr Glu Asp Thr Gly Val Tyr Val Cys Ser 
                85                  90                  95      


Ala Leu Ile Thr Pro Trp Thr Gly Asp Thr Arg Thr Tyr Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His 
        115                 120                 125             


Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp 
    130                 135                 140                 


Lys Gly Ala Ala His His His His His His 
145                 150                 


<210>  39
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103464B09 (parental)-FLAG-HIS6

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp 
        115                 120                 125             


Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys 
    130                 135                 140                 


Asp Asp Asp Asp Lys Gly Ala Ala His His His His His His 
145                 150                 155             


<210>  40
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta1 subunit

<400>  40

Met Gly Arg Leu Leu Ala Leu Val Val Gly Ala Ala Leu Val Ser Ser 
1               5                   10                  15      


Ala Cys Gly Gly Cys Val Glu Val Asp Ser Glu Thr Glu Ala Val Tyr 
            20                  25                  30          


Gly Met Thr Phe Lys Ile Leu Cys Ile Ser Cys Lys Arg Arg Ser Glu 
        35                  40                  45              


Thr Asn Ala Glu Thr Phe Thr Glu Trp Thr Phe Arg Gln Lys Gly Thr 
    50                  55                  60                  


Glu Glu Phe Val Lys Ile Leu Arg Tyr Glu Asn Glu Val Leu Gln Leu 
65                  70                  75                  80  


Glu Glu Asp Glu Arg Phe Glu Gly Arg Val Val Trp Asn Gly Ser Arg 
                85                  90                  95      


Gly Thr Lys Asp Leu Gln Asp Leu Ser Ile Phe Ile Thr Asn Val Thr 
            100                 105                 110         


Tyr Asn His Ser Gly Asp Tyr Glu Cys His Val Tyr Arg Leu Leu Phe 
        115                 120                 125             


Phe Glu Asn Tyr Glu His Asn Thr Ser Val Val Lys Lys Ile His Ile 
    130                 135                 140                 


Glu Val Val Asp Lys Ala Asn Arg Asp Met Ala Ser Ile Val Ser Glu 
145                 150                 155                 160 


Ile Met Met Tyr Val Leu Ile Val Val Leu Thr Ile Trp Leu Val Ala 
                165                 170                 175     


Glu Met Ile Tyr Cys Tyr Lys Lys Ile Ala Ala Ala Thr Glu Thr Ala 
            180                 185                 190         


Ala Gln Glu Asn Ala Ser Glu Tyr Leu Ala Ile Thr Ser Glu Ser Lys 
        195                 200                 205             


Glu Asn Cys Thr Gly Val Gln Val Ala Glu 
    210                 215             


<210>  41
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta2 subunit

<400>  41

Met His Arg Asp Ala Trp Leu Pro Arg Pro Ala Phe Ser Leu Thr Gly 
1               5                   10                  15      


Leu Ser Leu Phe Phe Ser Leu Val Pro Pro Gly Arg Ser Met Glu Val 
            20                  25                  30          


Thr Val Pro Ala Thr Leu Asn Val Leu Asn Gly Ser Asp Ala Arg Leu 
        35                  40                  45              


Pro Cys Thr Phe Asn Ser Cys Tyr Thr Val Asn His Lys Gln Phe Ser 
    50                  55                  60                  


Leu Asn Trp Thr Tyr Gln Glu Cys Asn Asn Cys Ser Glu Glu Met Phe 
65                  70                  75                  80  


Leu Gln Phe Arg Met Lys Ile Ile Asn Leu Lys Leu Glu Arg Phe Gln 
                85                  90                  95      


Asp Arg Val Glu Phe Ser Gly Asn Pro Ser Lys Tyr Asp Val Ser Val 
            100                 105                 110         


Met Leu Arg Asn Val Gln Pro Glu Asp Glu Gly Ile Tyr Asn Cys Tyr 
        115                 120                 125             


Ile Met Asn Pro Pro Asp Arg His Arg Gly His Gly Lys Ile His Leu 
    130                 135                 140                 


Gln Val Leu Met Glu Glu Pro Pro Glu Arg Asp Ser Thr Val Ala Val 
145                 150                 155                 160 


Ile Val Gly Ala Ser Val Gly Gly Phe Leu Ala Val Val Ile Leu Val 
                165                 170                 175     


Leu Met Val Val Lys Cys Val Arg Arg Lys Lys Glu Gln Lys Leu Ser 
            180                 185                 190         


Thr Asp Asp Leu Lys Thr Glu Glu Glu Gly Lys Thr Asp Gly Glu Gly 
        195                 200                 205             


Asn Pro Asp Asp Gly Ala Lys 
    210                 215 


<210>  42
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta3 subunit

<400>  42

Met Pro Ala Phe Asn Arg Leu Phe Pro Leu Ala Ser Leu Val Leu Ile 
1               5                   10                  15      


Tyr Trp Val Ser Val Cys Phe Pro Val Cys Val Glu Val Pro Ser Glu 
            20                  25                  30          


Thr Glu Ala Val Gln Gly Asn Pro Met Lys Leu Arg Cys Ile Ser Cys 
        35                  40                  45              


Met Lys Arg Glu Glu Val Glu Ala Thr Thr Val Val Glu Trp Phe Tyr 
    50                  55                  60                  


Arg Pro Glu Gly Gly Lys Asp Phe Leu Ile Tyr Glu Tyr Arg Asn Gly 
65                  70                  75                  80  


His Gln Glu Val Glu Ser Pro Phe Gln Gly Arg Leu Gln Trp Asn Gly 
                85                  90                  95      


Ser Lys Asp Leu Gln Asp Val Ser Ile Thr Val Leu Asn Val Thr Leu 
            100                 105                 110         


Asn Asp Ser Gly Leu Tyr Thr Cys Asn Val Ser Arg Glu Phe Glu Phe 
        115                 120                 125             


Glu Ala His Arg Pro Phe Val Lys Thr Thr Arg Leu Ile Pro Leu Arg 
    130                 135                 140                 


Val Thr Glu Glu Ala Gly Glu Asp Phe Thr Ser Val Val Ser Glu Ile 
145                 150                 155                 160 


Met Met Tyr Ile Leu Leu Val Phe Leu Thr Leu Trp Leu Leu Ile Glu 
                165                 170                 175     


Met Ile Tyr Cys Tyr Arg Lys Val Ser Lys Ala Glu Glu Ala Ala Gln 
            180                 185                 190         


Glu Asn Ala Ser Asp Tyr Leu Ala Ile Pro Ser Glu Asn Lys Glu Asn 
        195                 200                 205             


Ser Ala Val Pro Val Glu Glu 
    210                 215 


<210>  43
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A viral peptide

<400>  43

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  44
<211>  2220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNav1.7-beta1

<400>  44

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 
                645                 650                 655     


Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 
            660                 665                 670         


Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 
        675                 680                 685             


Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 
    690                 695                 700                 


Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 
705                 710                 715                 720 


Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 
                725                 730                 735     


Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
            740                 745                 750         


Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 
        755                 760                 765             


Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 
    770                 775                 780                 


Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 
785                 790                 795                 800 


Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 
                805                 810                 815     


Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
            820                 825                 830         


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
        835                 840                 845             


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
    850                 855                 860                 


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
865                 870                 875                 880 


Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 
                885                 890                 895     


Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
            900                 905                 910         


Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
        915                 920                 925             


Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 
    930                 935                 940                 


Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
945                 950                 955                 960 


Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn 
                965                 970                 975     


Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 
            980                 985                 990         


Gln Thr Leu Arg Glu Phe Ile Leu  Lys Ala Phe Ser Lys  Lys Pro Lys 
        995                 1000                 1005             


Ile Ser  Arg Glu Ile Arg Gln  Ala Glu Asp Leu Asn  Thr Lys Lys 
    1010                 1015                 1020             


Glu Asn  Tyr Ile Ser Asn His  Thr Leu Ala Glu Met  Ser Lys Gly 
    1025                 1030                 1035             


His Asn  Phe Leu Lys Glu Lys  Asp Lys Ile Ser Gly  Phe Gly Ser 
    1040                 1045                 1050             


Ser Val  Asp Lys His Leu Met  Glu Asp Ser Asp Gly  Gln Ser Phe 
    1055                 1060                 1065             


Ile His  Asn Pro Ser Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly 
    1070                 1075                 1080             


Glu Ser  Asp Leu Glu Asn Met  Asn Ala Glu Glu Leu  Ser Ser Asp 
    1085                 1090                 1095             


Ser Asp  Ser Glu Tyr Ser Lys  Val Arg Leu Asn Arg  Ser Ser Ser 
    1100                 1105                 1110             


Ser Glu  Cys Ser Thr Val Asp  Asn Pro Leu Pro Gly  Glu Gly Glu 
    1115                 1120                 1125             


Glu Ala  Glu Ala Glu Pro Met  Asn Ser Asp Glu Pro  Glu Ala Cys 
    1130                 1135                 1140             


Phe Thr  Asp Gly Cys Val Arg  Arg Phe Ser Cys Cys  Gln Val Asn 
    1145                 1150                 1155             


Ile Glu  Ser Gly Lys Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr 
    1160                 1165                 1170             


Cys Tyr  Lys Ile Val Glu His  Ser Trp Phe Glu Ser  Phe Ile Val 
    1175                 1180                 1185             


Leu Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1190                 1195                 1200             


Tyr Ile  Glu Arg Lys Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala 
    1205                 1210                 1215             


Asp Lys  Ile Phe Thr Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys 
    1220                 1225                 1230             


Trp Ile  Ala Tyr Gly Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys 
    1235                 1240                 1245             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Leu Val  Thr Leu Val 
    1250                 1255                 1260             


Ala Asn  Thr Leu Gly Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu 
    1265                 1270                 1275             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1280                 1285                 1290             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro 
    1295                 1300                 1305             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1310                 1315                 1320             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu 
    1325                 1330                 1335             


Cys Ile  Asn Thr Thr Asp Gly  Ser Arg Phe Pro Ala  Ser Gln Val 
    1340                 1345                 1350             


Pro Asn  Arg Ser Glu Cys Phe  Ala Leu Met Asn Val  Ser Gln Asn 
    1355                 1360                 1365             


Val Arg  Trp Lys Asn Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu 
    1370                 1375                 1380             


Gly Tyr  Leu Ser Leu Leu Gln  Val Ala Thr Phe Lys  Gly Trp Thr 
    1385                 1390                 1395             


Ile Ile  Met Tyr Ala Ala Val  Asp Ser Val Asn Val  Asp Lys Gln 
    1400                 1405                 1410             


Pro Lys  Tyr Glu Tyr Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Val 
    1415                 1420                 1425             


Phe Ile  Ile Phe Gly Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly 
    1430                 1435                 1440             


Val Ile  Ile Asp Asn Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly 
    1445                 1450                 1455             


Gln Asp  Ile Phe Met Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala 
    1460                 1465                 1470             


Met Lys  Lys Leu Gly Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg 
    1475                 1480                 1485             


Pro Gly  Asn Lys Ile Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn 
    1490                 1495                 1500             


Gln Ala  Phe Asp Ile Ser Ile  Met Val Leu Ile Cys  Leu Asn Met 
    1505                 1510                 1515             


Val Thr  Met Met Val Glu Lys  Glu Gly Gln Ser Gln  His Met Thr 
    1520                 1525                 1530             


Glu Val  Leu Tyr Trp Ile Asn  Val Val Phe Ile Ile  Leu Phe Thr 
    1535                 1540                 1545             


Gly Glu  Cys Val Leu Lys Leu  Ile Ser Leu Arg His  Tyr Tyr Phe 
    1550                 1555                 1560             


Thr Val  Gly Trp Asn Ile Phe  Asp Phe Val Val Val  Ile Ile Ser 
    1565                 1570                 1575             


Ile Val  Gly Met Phe Leu Ala  Asp Leu Ile Glu Thr  Tyr Phe Val 
    1580                 1585                 1590             


Ser Pro  Thr Leu Phe Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg 
    1595                 1600                 1605             


Ile Leu  Arg Leu Val Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu 
    1610                 1615                 1620             


Phe Ala  Leu Met Met Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu 
    1625                 1630                 1635             


Leu Leu  Phe Leu Val Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser 
    1640                 1645                 1650             


Asn Phe  Ala Tyr Val Lys Lys  Glu Asp Gly Ile Asn  Asp Met Phe 
    1655                 1660                 1665             


Asn Phe  Glu Thr Phe Gly Asn  Ser Met Ile Cys Leu  Phe Gln Ile 
    1670                 1675                 1680             


Thr Thr  Ser Ala Gly Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn 
    1685                 1690                 1695             


Ser Lys  Pro Pro Asp Cys Asp  Pro Lys Lys Val His  Pro Gly Ser 
    1700                 1705                 1710             


Ser Val  Glu Gly Asp Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr 
    1715                 1720                 1725             


Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu Val Val  Val Asn Met 
    1730                 1735                 1740             


Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu 
    1745                 1750                 1755             


Ser Thr  Glu Pro Leu Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu 
    1760                 1765                 1770             


Val Trp  Glu Lys Phe Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Phe 
    1775                 1780                 1785             


Ser Lys  Leu Ser Asp Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu 
    1790                 1795                 1800             


Ile Ala  Lys Pro Asn Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro 
    1805                 1810                 1815             


Met Val  Ser Gly Asp Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala 
    1820                 1825                 1830             


Phe Thr  Lys Arg Val Leu Gly  Glu Ser Gly Glu Met  Asp Ser Leu 
    1835                 1840                 1845             


Arg Ser  Gln Met Glu Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys 
    1850                 1855                 1860             


Val Ser  Tyr Glu Pro Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu 
    1865                 1870                 1875             


Asp Val  Ser Ala Thr Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg 
    1880                 1885                 1890             


Leu Arg  Gln Asn Val Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp 
    1895                 1900                 1905             


Gly Asp  Arg Asp Asp Asp Leu  Leu Asn Lys Lys Asp  Met Ala Phe 
    1910                 1915                 1920             


Asp Asn  Val Asn Glu Asn Ser  Ser Pro Glu Lys Thr  Asp Ala Thr 
    1925                 1930                 1935             


Ser Ser  Thr Thr Ser Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Asp Lys  Glu Lys Tyr Glu Gln  Asp Arg Thr Glu Lys  Glu Asp Lys 
    1955                 1960                 1965             


Gly Lys  Asp Ser Lys Glu Ser  Lys Lys Ser Gly Arg  Gly Ser Gly 
    1970                 1975                 1980             


Ala Thr  Asn Phe Ser Leu Leu  Lys Gln Ala Gly Asp  Val Glu Glu 
    1985                 1990                 1995             


Asn Pro  Gly Pro Met Gly Arg  Leu Leu Ala Leu Val  Val Gly Ala 
    2000                 2005                 2010             


Ala Leu  Val Ser Ser Ala Cys  Gly Gly Cys Val Glu  Val Asp Ser 
    2015                 2020                 2025             


Glu Thr  Glu Ala Val Tyr Gly  Met Thr Phe Lys Ile  Leu Cys Ile 
    2030                 2035                 2040             


Ser Cys  Lys Arg Arg Ser Glu  Thr Asn Ala Glu Thr  Phe Thr Glu 
    2045                 2050                 2055             


Trp Thr  Phe Arg Gln Lys Gly  Thr Glu Glu Phe Val  Lys Ile Leu 
    2060                 2065                 2070             


Arg Tyr  Glu Asn Glu Val Leu  Gln Leu Glu Glu Asp  Glu Arg Phe 
    2075                 2080                 2085             


Glu Gly  Arg Val Val Trp Asn  Gly Ser Arg Gly Thr  Lys Asp Leu 
    2090                 2095                 2100             


Gln Asp  Leu Ser Ile Phe Ile  Thr Asn Val Thr Tyr  Asn His Ser 
    2105                 2110                 2115             


Gly Asp  Tyr Glu Cys His Val  Tyr Arg Leu Leu Phe  Phe Glu Asn 
    2120                 2125                 2130             


Tyr Glu  His Asn Thr Ser Val  Val Lys Lys Ile His  Ile Glu Val 
    2135                 2140                 2145             


Val Asp  Lys Ala Asn Arg Asp  Met Ala Ser Ile Val  Ser Glu Ile 
    2150                 2155                 2160             


Met Met  Tyr Val Leu Ile Val  Val Leu Thr Ile Trp  Leu Val Ala 
    2165                 2170                 2175             


Glu Met  Ile Tyr Cys Tyr Lys  Lys Ile Ala Ala Ala  Thr Glu Thr 
    2180                 2185                 2190             


Ala Ala  Gln Glu Asn Ala Ser  Glu Tyr Leu Ala Ile  Thr Ser Glu 
    2195                 2200                 2205             


Ser Lys  Glu Asn Cys Thr Gly  Val Gln Val Ala Glu  
    2210                 2215                 2220 


<210>  45
<211>  1984
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muNav1.7

<400>  45

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ser Glu Glu Lys Ala 
            20                  25                  30          


Lys Gly His Lys Asp Glu Lys Lys Asp Asp Glu Glu Glu Gly Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Lys Asp Leu Glu Gln Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Ser Thr Ala Glu Ser Glu Glu Glu Leu Lys Arg Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Glu Cys Val Thr Ala Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Gly Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Leu Gly Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Arg Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Lys Gln Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp Asp 
                485                 490                 495     


Glu Lys Leu Ser Lys Ser Gly Ser Glu Glu Ser Ile Arg Lys Lys Ser 
            500                 505                 510         


Phe His Leu Gly Val Glu Gly His His Arg Ala Arg Glu Lys Arg Leu 
        515                 520                 525             


Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe Ser 
    530                 535                 540                 


Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg Gly 
545                 550                 555                 560 


Arg Asp Leu Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile 
                565                 570                 575     


Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His Arg 
            580                 585                 590         


Pro Arg Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser Pro 
        595                 600                 605             


Pro Val Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys Asn 
    610                 615                 620                 


Gly Val Val Ser Leu Val Asp Gly Pro Ser Ala Leu Met Leu Pro Asn 
625                 630                 635                 640 


Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp Asp 
                645                 650                 655     


Ser Gly Thr Thr Asn Gln Met Arg Lys Lys Arg Leu Ser Ser Ser Tyr 
            660                 665                 670         


Phe Leu Ser Glu Asp Met Leu Asn Asp Pro His Leu Arg Gln Arg Ala 
        675                 680                 685             


Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu Glu 
    690                 695                 700                 


Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Thr Phe 
705                 710                 715                 720 


Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Phe Ile 
                725                 730                 735     


Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
            740                 745                 750         


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met Thr 
        755                 760                 765             


Asp Glu Phe Lys Asn Val Leu Ala Val Gly Asn Leu Val Phe Thr Gly 
    770                 775                 780                 


Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr 
785                 790                 795                 800 


Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val Thr 
                805                 810                 815     


Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
        835                 840                 845             


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
    850                 855                 860                 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
865                 870                 875                 880 


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
                885                 890                 895     


Lys Ile Asn Glu Asn Cys Lys Leu Pro Arg Trp His Met Asn Asp Phe 
            900                 905                 910         


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
        915                 920                 925             


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
    930                 935                 940                 


Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
945                 950                 955                 960 


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Thr 
                965                 970                 975     


Ala Ile Glu Glu Asp Thr Asp Ala Asn Asn Leu Gln Ile Ala Val Ala 
            980                 985                 990         


Arg Ile Lys Arg Gly Ile Asn Tyr  Val Lys Gln Thr Leu  Arg Glu Phe 
        995                 1000                 1005             


Ile Leu  Lys Ser Phe Ser Lys  Lys Pro Lys Gly Ser  Lys Asp Thr 
    1010                 1015                 1020             


Lys Arg  Thr Ala Asp Pro Asn  Asn Lys Arg Glu Asn  Tyr Ile Ser 
    1025                 1030                 1035             


Asn Arg  Thr Leu Ala Glu Ile  Ser Lys Asp His Asn  Phe Leu Lys 
    1040                 1045                 1050             


Glu Lys  Asp Lys Ile Ser Gly  Phe Ser Ser Ser Leu  Asp Lys Ser 
    1055                 1060                 1065             


Phe Met  Asp Glu Asn Asp Tyr  Gln Ser Phe Ile His  Asn Pro Ser 
    1070                 1075                 1080             


Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly Glu Ser  Asp Leu Glu 
    1085                 1090                 1095             


Asn Met  Asn Thr Glu Glu Leu  Ser Ser Asp Ser Asp  Ser Asp Tyr 
    1100                 1105                 1110             


Ser Lys  Glu Arg Arg Asn Arg  Ser Ser Ser Ser Glu  Cys Ser Thr 
    1115                 1120                 1125             


Val Asp  Asn Pro Leu Pro Gly  Glu Glu Glu Ala Glu  Ala Glu Pro 
    1130                 1135                 1140             


Ile Asn  Ala Asp Glu Pro Glu  Ala Cys Phe Thr Asp  Gly Cys Val 
    1145                 1150                 1155             


Arg Arg  Phe Pro Cys Cys Gln  Val Asn Ile Asp Thr  Gly Lys Gly 
    1160                 1165                 1170             


Lys Val  Trp Trp Thr Ile Arg  Lys Thr Cys Tyr Arg  Ile Val Glu 
    1175                 1180                 1185             


His Ser  Trp Phe Glu Ser Phe  Ile Val Leu Met Ile  Leu Leu Ser 
    1190                 1195                 1200             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Ile Glu  Lys Lys Lys 
    1205                 1210                 1215             


Thr Ile  Lys Ile Ile Leu Glu  Tyr Ala Asp Lys Ile  Phe Thr Tyr 
    1220                 1225                 1230             


Ile Phe  Ile Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Tyr 
    1235                 1240                 1245             


Lys Thr  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1250                 1255                 1260             


Val Asp  Val Ser Leu Val Thr  Leu Val Ala Asn Thr  Leu Gly Tyr 
    1265                 1270                 1275             


Ser Asp  Leu Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1280                 1285                 1290             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1295                 1300                 1305             


Val Asn  Ala Leu Ile Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1310                 1315                 1320             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1325                 1330                 1335             


Asn Leu  Phe Ala Gly Lys Phe  Tyr Glu Cys Val Asn  Thr Thr Asp 
    1340                 1345                 1350             


Gly Ser  Arg Phe Ser Val Ser  Gln Val Ala Asn Arg  Ser Glu Cys 
    1355                 1360                 1365             


Phe Ala  Leu Met Asn Val Ser  Gly Asn Val Arg Trp  Lys Asn Leu 
    1370                 1375                 1380             


Lys Val  Asn Phe Asp Asn Val  Gly Leu Gly Tyr Leu  Ser Leu Leu 
    1385                 1390                 1395             


Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1400                 1405                 1410             


Val Asp  Ser Val Asn Val Asn  Ala Gln Pro Ile Tyr  Glu Tyr Asn 
    1415                 1420                 1425             


Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1430                 1435                 1440             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1445                 1450                 1455             


Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr 
    1460                 1465                 1470             


Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser 
    1475                 1480                 1485             


Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Gly Asn  Lys Phe Gln 
    1490                 1495                 1500             


Gly Cys  Ile Phe Asp Leu Val  Thr Asn Gln Ala Phe  Asp Ile Thr 
    1505                 1510                 1515             


Ile Met  Val Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu 
    1520                 1525                 1530             


Lys Glu  Gly Gln Thr Asp Tyr  Met Ser Phe Val Leu  Tyr Trp Ile 
    1535                 1540                 1545             


Asn Val  Val Phe Ile Ile Leu  Phe Thr Gly Glu Cys  Val Leu Lys 
    1550                 1555                 1560             


Leu Ile  Ser Leu Arg His Tyr  Tyr Phe Thr Val Gly  Trp Asn Ile 
    1565                 1570                 1575             


Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Gly  Met Phe Leu 
    1580                 1585                 1590             


Ala Glu  Met Ile Glu Lys Tyr  Phe Val Ser Pro Thr  Leu Phe Arg 
    1595                 1600                 1605             


Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Lys 
    1610                 1615                 1620             


Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser 
    1625                 1630                 1635             


Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met 
    1640                 1645                 1650             


Phe Ile  Tyr Ala Ile Phe Gly  Met Ser Asn Phe Ala  Tyr Val Lys 
    1655                 1660                 1665             


Lys Glu  Ala Gly Ile Asn Asp  Met Phe Asn Phe Glu  Thr Phe Gly 
    1670                 1675                 1680             


Asn Ser  Met Ile Cys Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp 
    1685                 1690                 1695             


Asp Gly  Leu Leu Ala Pro Ile  Leu Asn Ser Ala Pro  Pro Asp Cys 
    1700                 1705                 1710             


Asp Pro  Lys Lys Val His Pro  Gly Ser Ser Val Glu  Gly Asp Cys 
    1715                 1720                 1725             


Gly Asn  Pro Ser Val Gly Ile  Phe Tyr Phe Val Ser  Tyr Ile Ile 
    1730                 1735                 1740             


Ile Ser  Phe Leu Val Val Val  Asn Met Tyr Ile Ala  Val Ile Leu 
    1745                 1750                 1755             


Glu Asn  Phe Ser Val Ala Thr  Glu Glu Ser Thr Glu  Pro Leu Ser 
    1760                 1765                 1770             


Glu Asp  Asp Phe Glu Met Phe  Tyr Glu Val Trp Glu  Lys Phe Asp 
    1775                 1780                 1785             


Pro Asp  Ala Thr Gln Phe Ile  Glu Phe Cys Lys Leu  Ser Asp Phe 
    1790                 1795                 1800             


Ala Ala  Ala Leu Asp Pro Pro  Leu Leu Ile Ala Lys  Pro Asn Lys 
    1805                 1810                 1815             


Val Gln  Leu Ile Ala Met Asp  Leu Pro Met Val Ser  Gly Asp Arg 
    1820                 1825                 1830             


Ile His  Cys Leu Asp Ile Leu  Phe Ala Phe Thr Lys  Arg Val Leu 
    1835                 1840                 1845             


Gly Glu  Ser Gly Glu Met Asp  Ser Leu Arg Ser Gln  Met Glu Glu 
    1850                 1855                 1860             


Arg Phe  Met Ser Ala Asn Pro  Ser Lys Val Ser Tyr  Glu Pro Ile 
    1865                 1870                 1875             


Thr Thr  Thr Leu Lys Arg Lys  Gln Glu Asp Val Ser  Ala Thr Ile 
    1880                 1885                 1890             


Ile Gln  Arg Ala Tyr Arg Arg  Tyr Arg Leu Arg Gln  Asn Val Lys 
    1895                 1900                 1905             


Asn Ile  Ser Ser Ile Tyr Ile  Lys Asp Gly Asp Arg  Asp Asp Asp 
    1910                 1915                 1920             


Leu Pro  Asn Lys Glu Asp Ile  Val Phe Asp Asn Val  Asn Glu Asn 
    1925                 1930                 1935             


Ser Ser  Pro Glu Lys Thr Asp  Ala Thr Ala Ser Thr  Ile Ser Pro 
    1940                 1945                 1950             


Pro Ser  Tyr Asp Ser Val Thr  Lys Pro Asp Gln Glu  Lys Tyr Glu 
    1955                 1960                 1965             


Thr Asp  Lys Thr Glu Lys Glu  Asp Lys Glu Lys Asp  Glu Ser Arg 
    1970                 1975                 1980             


Lys 
    


<210>  46
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103262B06 (parental)

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Thr Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu Phe Val 
        35                  40                  45              


Ala His Ile Asn Phe Ser Gly Ser Ser Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Trp Val Ala Gly Pro Pro Arg Tyr Asp Tyr Glu Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  47
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103262C02 (parental)

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Leu Pro Phe Gly Leu Tyr 
            20                  25                  30          


Ile Leu Gly Trp Ile Arg Arg Ala Pro Gly Lys Glu Arg Asp Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Arg Asp Thr Val Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Arg Met Asp Asn Leu Arg Pro Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Val Asp Ser Val Pro Arg Gly Thr Pro Thr Ile Thr Glu Ser Glu 
            100                 105                 110         


Tyr Ala Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  48
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103265A11 (parental)

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Ala Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Tyr Thr Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ser 
                85                  90                  95      


Leu Ser Arg Tyr Leu Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  49
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103265B04 (parental)

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Ser Phe Ile Phe Ser Asn Asn 
            20                  25                  30          


Tyr Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Trp Val 
        35                  40                  45              


Ala Arg Ile Thr Gly Arg Gly Asn Thr Asn Tyr Leu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Glu Ile Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ala Leu Trp Tyr Gly Gly Arg Ala Trp Gly Lys Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  50
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103275B05 (parental)

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  51
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103362B08 (parental)

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  52
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G04 (parental)

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Lys Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Val Thr Pro Thr Gly Ser Ile Ser Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Arg Trp Ser Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  53
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G05 (parental)

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  54
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103454D07 (parental)

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Gly Ile Ile Asn Ile Asn 
            20                  25                  30          


Tyr Ile Ala Trp Tyr Arg Gln Thr Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Arg Ile Ser Ser Asp Asp Thr Ile Lys Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Met Ser Arg Asp Lys Val Lys Asn Met Val His Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Thr Glu Asp Thr Gly Val Tyr Val Cys Ser 
                85                  90                  95      


Ala Leu Ile Thr Pro Trp Thr Gly Asp Thr Arg Thr Tyr Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  55
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103464B09 (parental)

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  56
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG-HIS6 peptide

<400>  56

Ala Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
1               5                   10                  15      


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
            20                  25                  30          


His His 
        


<210>  57
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human VH3-JH consensus


<220>
<221>  MISC_FEATURE
<222>  (99)..(114)
<223>  Xaa= are each independently any amino acid except Cys

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  58
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH2-consensus

<400>  58

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala 
    


<210>  59
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G04_SO

<400>  59

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Asp Asp Gly Ser Lys Arg Val Ser Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ser Tyr Ser Gly Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  60
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G05_SO

<400>  60

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Asp Asp Gly Ser Lys Arg Val Ser Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ser Tyr Ser Gly Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  61
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103464B09_SO

<400>  61

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Gly Gly Asn Thr Gln Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  62
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nav1.7 alpha epitope

<400>  62

Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser Ile Met Asn 
1               5                   10                  15      


Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr Tyr Leu Glu 
            20                  25                  30          


Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp Ser Gly Gln 
        35                  40                  45              


Cys Pro Glu Gly Tyr Thr Cys Val 
    50                  55      


<210>  63
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nav1.7 alpha Domain I

<400>  63

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp 
                645                 650                 655     


Asp Ser Gly Thr Thr Asn Gln Ile His Lys Lys Arg Arg Cys Ser Ser 
            660                 665                 670         


Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro Asn Leu Arg Gln Arg 
        675                 680                 685             


Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu 
    690                 695                 700                 


Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Lys 
705                 710                 715                 720 


Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Cys 
                725                 730                 735     


Ile Tyr 
        


<210>  64
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nav1.7alpha Domain I S5-S6 loop

<400>  64

Lys His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu 
1               5                   10                  15      


Ser Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe 
            20                  25                  30          


Tyr Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr 
        35                  40                  45              


Asp Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg 
    50                  55                  60                  


Asn Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe 
65                  70                  75                  80  


Leu Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr 
                85                  90                  95      


Gln Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr 
            100                 105         


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nav1.7 alpha Exon 5N

<400>  65

Tyr Leu Thr Glu Phe Val Asn Leu Gly Asn Val Ser 
1               5                   10          


<210>  66
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nav1.7 alpha Exon 5A

<400>  66

Tyr Val Thr Glu Phe Val Asp Leu Gly Asn Val Ser 
1               5                   10          


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nav1.7 alpha Exon 11S

<400>  67

Leu Pro Asn Gly Gln Leu Leu Pro Glu 
1               5                   


<210>  68
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nav1.7 alpha Exon 11L

<400>  68

Leu Pro Asn Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr 
1               5                   10                  15      


Ser Asp Asp Ser 
            20  


<210>  69
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301461 F0103275B05

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Ser Thr Asn Gly Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  70
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301635 F0103275B05

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Asn Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  71
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301636 F0103275B05

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Asn Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  72
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301637 F0103275B05

<400>  72

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Asn Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  73
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301638 F0103275B05

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Asn Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  74
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301639 F0103275B05

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  75
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301640 F0103275B05(R76_V78insT)(L11V,T83R,V89L)

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  76
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301641 F0103275B05

<400>  76

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  77
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301642 F0103275B05

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  78
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301652 F0103275B05

<400>  78

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Ser Thr Asn Gly Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  79
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301653 F0103275B05

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Ser Thr Asn Gly Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  80
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301654 F0103275B05

<400>  80

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Ser Thr Asn Gly Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  81
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301655 F0103275B05

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Ser Thr Asn Gly Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  82
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301556 F0103387G05

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Gly Gly Ser Ala Thr Gly Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  83
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301563 F0103387G05

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Gly Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  84
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301849 F0103387G05

<400>  84

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Gly Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  85
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301850 F0103387G05

<400>  85

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Gly Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  86
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301643 F0103387G05

<400>  86

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  87
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301644 F0103387G05

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp Tyr Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  88
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301645 F0103387G05

<400>  88

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Ala Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  89
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301646 F0103387G05

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  90
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301647 F0103387G05

<400>  90

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  91
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301648 F0103387G05

<400>  91

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  92
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301649 F0103387G05

<400>  92

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  93
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302307 F0103387G05

<400>  93

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Gly Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  94
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010302308 F0103387G05

<400>  94

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Gly Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Tyr Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  95
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010302309 F0103387G05

<400>  95

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Gly Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gln Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  96
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302391 F0103387G05

<400>  96

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Gly Gly Ser Ala Thr Gly Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  97
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010302392 F0103387G05

<400>  97

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Gly Gly Ser Ala Thr Gly Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gln Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  98
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301868 
       F0103464B09(L11V,S68T,T79Y,R81Q,S82aN,N82bS,K83R,G88A,V89L)

<400>  98

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  99
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301869 F0103464B09

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  100
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301870 F0103464B09

<400>  100

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Asn Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  101
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301871 F0103464B09

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  102
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301872 F0103464B09

<400>  102

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  103
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301873 F0103464B09

<400>  103

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  104
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301874 F0103464B09

<400>  104

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  105
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301875 F0103464B09

<400>  105

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  106
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301876 F0103464B09

<400>  106

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  107
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301877 F0103464B09

<400>  107

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  108
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301892 F0103464B09

<400>  108

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Leu Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  109
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301893 F0103464B09

<400>  109

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  110
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010301932 F0103464B09

<400>  110

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Arg Pro Glu Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  111
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301933 F0103464B09

<400>  111

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Arg Pro Glu Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  112
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301934 F0103464B09

<400>  112

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Arg Pro Glu Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  113
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301935 F0103464B09

<400>  113

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Tyr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Arg Pro Glu Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  114
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301936 F0103464B09

<400>  114

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Leu Arg Pro Glu Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  115
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301937 F0103464B09

<400>  115

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Asn Asn Leu Arg Pro Glu Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  116
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301938 F0103464B09

<400>  116

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Ser Leu Arg Pro Glu Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  117
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301939 F0103464B09

<400>  117

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  118
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302333 F0103464B09

<400>  118

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Glu Gly Asn Thr Asn Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  119
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302334 F0103464B09

<400>  119

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Glu Gly Asn Thr Gln Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  120
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302335 F0103464B09

<400>  120

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Ser Gly Asn Thr Gln Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  121
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302336 F0103464B09

<400>  121

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Glu Gly Asn Thr Gln Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  122
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302337 F0103464B09

<400>  122

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Gly Gly Asn Thr Gln Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  123
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302338 F0103464B09

<400>  123

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Ser Gly Asn Thr Gln Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  124
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302339 F0103464B09

<400>  124

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Gly Gly Asn Thr Gln Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  125
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302340 F0103464B09

<400>  125

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Leu Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Ser Gly Asn Thr Asn Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  126
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302341 F0103464B09

<400>  126

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Glu Gly Asn Thr Asn Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  127
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302342 F0103464B09

<400>  127

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Glu Gly Asn Thr Gln Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  128
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302343 F0103464B09

<400>  128

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Ser Gly Asn Thr Gln Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  129
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302344 F0103464B09

<400>  129

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Glu Gly Asn Thr Gln Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  130
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302345 F0103464B09

<400>  130

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Gly Gly Asn Thr Gln Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  131
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302346 F0103464B09

<400>  131

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Ser Gly Asn Thr Gln Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  132
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302346 F0103464B09(

<400>  132

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Gly Gly Asn Thr Gln Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  133
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302348 F0103464B09

<400>  133

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Leu Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Ser Gly Asn Thr Asn Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  134
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302349 F0103464B09

<400>  134

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Glu Gly Asn Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  135
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302350 F0103464B09

<400>  135

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Glu Gly Asn Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  136
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302351 F0103464B09

<400>  136

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Ser Gly Asn Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  137
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302352 F0103464B09

<400>  137

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Glu Gly Asn Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  138
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302353 F0103464B09

<400>  138

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Gly Gly Asn Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  139
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302354 F0103464B09

<400>  139

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Ser Gly Asn Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  140
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302355 F0103464B09

<400>  140

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Gly Gly Asn Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  141
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302356 F0103464B09

<400>  141

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Leu Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Ser Gly Asn Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  142
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302357 F0103464B09

<400>  142

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Glu Gly Asn Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  143
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302358 F0103464B09

<400>  143

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Glu Gly Asn Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  144
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302359 F0103464B09

<400>  144

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Ser Gly Asn Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  145
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302360 F0103464B09

<400>  145

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Glu Gly Asn Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  146
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302361 F0103464B09

<400>  146

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Gly Gly Asn Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  147
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302362 F0103464B09

<400>  147

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Ser Gly Asn Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  148
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302363 F0103464B09

<400>  148

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Gly Gly Asn Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  149
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302364 F0103464B09

<400>  149

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Leu Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Ser Gly Asn Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  150
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302365 F0103464B09

<400>  150

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  151
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302366 F0103464B09

<400>  151

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  152
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302367 F0103464B09

<400>  152

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  153
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302368 F0103464B09

<400>  153

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  154
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301656 F0103387G04

<400>  154

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Arg Trp Ser Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  155
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301840 F0103387G04

<400>  155

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Arg Thr Trp Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Leu Leu Gln Pro Asp Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  156
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301841 F0103387G04

<400>  156

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Arg Trp Ser Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  157
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301842 F0103387G04

<400>  157

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Arg Trp Ser Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  158
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301843 F0103387G04

<400>  158

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Arg Trp Ser Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  159
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301844 F0103387G04

<400>  159

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Asn Trp Ser Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  160
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301845 F0103387G04

<400>  160

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Arg Val Ser Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  161
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301846 F0103387G04

<400>  161

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Arg Trp Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  162
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301847 F0103387G04

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  163
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301847 F0103387G04

<400>  163

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  164
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301865 F0103387G04

<400>  164

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser 
        115                 


<210>  165
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301866 F0103387G04

<400>  165

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Asn Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  166
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302310 F0103387G04

<400>  166

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ala Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Arg Arg Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  167
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302311 F0103387G04

<400>  167

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Arg Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Arg Arg Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  168
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302312 F0103387G04

<400>  168

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Ile Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  169
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302313 F0103387G04

<400>  169

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ala Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Ile Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  170
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302314 F0103387G04

<400>  170

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Arg Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Ile Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  171
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302315 F0103387G04

<400>  171

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Arg Ser Tyr Ser Ile Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  172
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302316 F0103387G04

<400>  172

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ala Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Arg Ser Tyr Ser Ile Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  173
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302317 F0103387G04

<400>  173

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Arg Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Arg Ser Tyr Ser Ile Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  174
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302318 F0103387G04

<400>  174

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Arg Tyr Ser Ile Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  175
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302319 F0103387G04

<400>  175

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ala Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Arg Tyr Ser Ile Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  176
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302320 F0103387G04

<400>  176

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ala Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  177
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302321 F0103387G04

<400>  177

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Arg Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Arg Tyr Ser Ile Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  178
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302322 F0103387G04

<400>  178

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Arg Arg Tyr Ser Ile Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  179
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302323 F0103387G04

<400>  179

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ala Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Arg Arg Tyr Ser Ile Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  180
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302324 F0103387G04

<400>  180

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Arg Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Arg Arg Tyr Ser Ile Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  181
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302325 F0103387G04

<400>  181

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Arg Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  182
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >F010302326 F0103387G04

<400>  182

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Arg Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  183
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302327 F0103387G04

<400>  183

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ala Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Arg Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  184
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302328 F0103387G04

<400>  184

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Arg Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Arg Ser Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  185
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302329 F0103387G04(

<400>  185

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Arg Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  186
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302330 F0103387G04

<400>  186

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ala Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Arg Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  187
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302331 F0103387G04

<400>  187

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Arg Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Arg Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  188
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302332 F0103387G04

<400>  188

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Arg Arg Tyr Ser Asn Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  189
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302370 F0103387G04

<400>  189

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Arg Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ser Tyr Ser Ile Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  190
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302371 F0103387G04

<400>  190

Phe Phe Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
1               5                   10                  15      


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe 
            20                  25                  30          


Asn Ile Asn Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              


Glu Leu Val Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Arg Ser Lys Arg Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      


Cys Arg Ala Leu Leu Gln Pro Asn Val Tyr Ser Ile Thr Arg Thr Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  191
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302372 F0103387G04

<400>  191

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Arg Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Asp Val Tyr Ser Ile Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  192
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302383 F0103387G04

<400>  192

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Gly Gly Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ser Tyr Ser Gly Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  193
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302384 F0103387G04

<400>  193

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Gly Gly Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ser Tyr Ser Ile Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  194
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302385 F0103387G04

<400>  194

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Gln Gly Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ser Tyr Ser Gly Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  195
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302386 F0103387G04

<400>  195

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Val Thr Pro Thr Gly Asp Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Gln Gly Ser Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ser Tyr Ser Ile Thr Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  196
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103275B05-CDR1

<400>  196

Gly Ser Ile Phe Asn Ile Asn Ser Met Ala 
1               5                   10  


<210>  197
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103275B05-CDR1-A

<400>  197

Gly Ser Ile Phe Asn Ile Asn Arg Met Ala 
1               5                   10  


<210>  198
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103275B05-CDR2

<400>  198

Ser Ser Thr Asn Gly Gly Ser Thr Asn 
1               5                   


<210>  199
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103275B05-CDR2-A

<400>  199

Tyr Ser Thr Asn Gly Gly Asp Thr Asn 
1               5                   


<210>  200
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103275B05-CDR3

<400>  200

Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr 
1               5                   10              


<210>  201
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G05-CDR1

<400>  201

Gly Arg Ile Leu Arg Ile Gly Tyr Met Arg 
1               5                   10  


<210>  202
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G05-CDR2

<400>  202

Arg Ile Thr Asp Asp Ser Ala Thr Asp 
1               5                   


<210>  203
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G05-CDR2-A

<400>  203

Arg Ile Thr Gly Gly Ser Ala Thr Gly 
1               5                   


<210>  204
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G05-CDR2-B

<400>  204

Arg Ile Thr Asp Asp Ser Ala Thr Gly 
1               5                   


<210>  205
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G05-CDR2-C

<400>  205

Arg Ile Thr Gly Gly Ser Ala Thr Gly 
1               5                   


<210>  206
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G05-CDR3

<400>  206

Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr Tyr 
1               5                   10                  15      


<210>  207
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103464B09-CDR1

<400>  207

Ser Arg Ala Phe Ile Arg Asp Val Phe Thr Gly 
1               5                   10      


<210>  208
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103464B09-CDR1-A

<400>  208

Ser Arg Ala Phe Ile Arg Asp Leu Phe Thr Gly 
1               5                   10      


<210>  209
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103464B09-CDR1-B

<400>  209

Ser Arg Gln Phe Ile Arg Asp Val Phe Thr Gly 
1               5                   10      


<210>  210
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103464B09-CDR1-C

<400>  210

His Arg Gln Phe Ile Arg Asp Val Phe Thr Gly 
1               5                   10      


<210>  211
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103464B09-CDR1-D

<400>  211

His Arg Ala Phe Ile Arg Asp Val Phe Thr Gly 
1               5                   10      


<210>  212
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103464B09-CDR1-E

<400>  212

His Arg Ala Phe Ile Arg Asp Leu Phe Thr Gly 
1               5                   10      


<210>  213
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103464B09-CDR2

<400>  213

Arg Ile Tyr Asn Gly Gly Asn Thr Asn 
1               5                   


<210>  214
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103464B09-CDR2-A

<400>  214

Arg Ile Tyr Asn Glu Gly Asn Thr Asn 
1               5                   


<210>  215
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103464B09-CDR2-B

<400>  215

Arg Ile Tyr Asn Glu Gly Asn Thr Gln 
1               5                   


<210>  216
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103464B09-CDR2-C

<400>  216

Arg Ile Tyr Glu Ser Gly Asn Thr Gln 
1               5                   


<210>  217
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103464B09-CDR2-

<400>  217

Arg Ile Tyr Glu Ser Gly Asn Thr Asn 
1               5                   


<210>  218
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103464B09-CDR2-E

<400>  218

Arg Ile Tyr Asn Glu Gly Asn Thr Asn 
1               5                   


<210>  219
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103464B09-CDR3

<400>  219

Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp Tyr 
1               5                   10                  15  


<210>  220
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103464B09-CDR3-A

<400>  220

Ser Gly Thr Ile Ser Thr Gly Arg Glu Tyr Arg Ser Gly Asp Tyr 
1               5                   10                  15  


<210>  221
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G04-CDR1

<400>  221

Gly Pro Val Phe Asn Ile Asn Lys Met Ala 
1               5                   10  


<210>  222
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G04-CDR1-A

<400>  222

Gly Pro Val Phe Asn Ile Asn Arg Met Ala 
1               5                   10  


<210>  223
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G04-CDR2

<400>  223

Ser Val Thr Pro Thr Gly Ser Ile Ser 
1               5                   


<210>  224
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G04-CDR2-A

<400>  224

Tyr Val Thr Pro Thr Gly Asp Ile Ser 
1               5                   


<210>  225
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G04-CDR3

<400>  225

Leu Leu Gln Pro Asp Ser Tyr Ser Asn Thr Arg Thr Tyr 
1               5                   10              


<210>  226
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G04-CDR3-A

<400>  226

Leu Leu Gln Pro Arg Arg Tyr Ser Asn Thr Arg Thr Tyr 
1               5                   10              


<210>  227
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G04-CDR3-B

<400>  227

Leu Leu Gln Pro Asp Ser Tyr Ser Ile Thr Arg Thr Tyr 
1               5                   10              


<210>  228
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G04-CDR3-C

<400>  228

Leu Leu Gln Pro Arg Ser Tyr Ser Ile Thr Arg Thr Tyr 
1               5                   10              


<210>  229
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G04-CDR3-B

<400>  229

Leu Leu Gln Pro Arg Ser Tyr Ser Asn Thr Arg Thr Tyr 
1               5                   10              


<210>  230
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G04-CDR3-E

<400>  230

Leu Leu Gln Pro Ser Ser Tyr Ser Ile Thr Arg Thr Tyr 
1               5                   10              


<210>  231
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G04-CDR3-F

<400>  231

Leu Leu Gln Pro Asn Val Tyr Ser Ile Thr Arg Thr Tyr 
1               5                   10              


<210>  232
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G04-CDR3-G

<400>  232

Leu Leu Gln Pro Asp Val Tyr Ser Ile Thr Arg Thr Tyr 
1               5                   10              


<210>  233
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103387G04-CDR3-H

<400>  233

Leu Leu Gln Pro Ser Ser Tyr Ser Gly Thr Arg Thr Tyr 
1               5                   10              


<210>  234
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALB11002 ( "ALB201") without C-terminal A,


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X = is L or V,

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  X= is V or L

<400>  234

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Xaa Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  235
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSA-CDR1

<400>  235

Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
1               5                   10  


<210>  236
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSA-CDR2

<400>  236

Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu 
1               5                   10  


<210>  237
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSA-CDR3

<400>  237

Gly Gly Ser Leu Ser Arg 
1               5       


<210>  238
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALB11002 ( "ALB201"),


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is L or V

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  X is  V or L

<400>  238

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Xaa Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala 
        115     


<210>  239
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALB11002 ( "ALB201") E1D L11V L93V without C-terminal A

<400>  239

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  240
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALB11002 ( "ALB201") E1D L11V L93V

<400>  240

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala 
        115     


<210>  241
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB11 without C-terminal A

<400>  241

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  242
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB11

<400>  242

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  243
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9GS-linker

<400>  243

Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210>  244
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20GS linker

<400>  244

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  245
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  35GS linker

<400>  245

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  246
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker subunit

<400>  246

Gly Gly Gly Ser 
1               


<210>  247
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103262B06-CDR1

<400>  247

Thr Arg Thr Phe Ser Thr Tyr Ala Met Gly 
1               5                   10  


<210>  248
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103262B06-CDR2

<400>  248

His Ile Asn Phe Ser Gly Ser Ser Thr Arg Tyr 
1               5                   10      


<210>  249
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103262B06-CDR3

<400>  249

Ala Arg Trp Val Ala Gly Pro Pro Arg Tyr Asp Tyr Glu Tyr 
1               5                   10                  


<210>  250
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103262C02-CDR1

<400>  250

Gly Leu Pro Phe Gly Leu Tyr Ile Leu Gly 
1               5                   10  


<210>  251
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103262C02-CDR2

<400>  251

Ala Ile Ser Arg Ser Gly Arg Asp Thr Val 
1               5                   10  


<210>  252
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103262C02-CDR3

<400>  252

Asp Ser Val Pro Arg Gly Thr Pro Thr Ile Thr Glu Ser Glu Tyr Ala 
1               5                   10                  15      


Ile 
    


<210>  253
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103265A11-CDR1

<400>  253

Gly Met Leu Phe Asn Ala Asn Thr Gln Gly 
1               5                   10  


<210>  254
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103265A11-CDR2

<400>  254

Phe Ile Phe Ser Gly Gly Tyr Thr Asn 
1               5                   


<210>  255

<400>  255
000

<210>  256
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103265B04-CDR1

<400>  256

Ser Phe Ile Phe Ser Asn Asn Tyr Met Glu 
1               5                   10  


<210>  257
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103265B04-CDR2

<400>  257

Arg Ile Thr Gly Arg Gly Asn Thr Asn 
1               5                   


<210>  258
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103265B04-CDR3

<400>  258

Leu Trp Tyr Gly Gly Arg Ala 
1               5           


<210>  259
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103362B08-CDR1

<400>  259

Val Arg Pro Phe Ser Thr Ser Ala Met Gly 
1               5                   10  


<210>  260
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103362B08-CDR2

<400>  260

Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr 
1               5                   10  


<210>  261
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103362B08-CDR3

<400>  261

Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr Glu Tyr 
1               5                   10                  15      


<210>  262
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103454D07-CDR1

<400>  262

Gly Gly Ile Ile Asn Ile Asn Tyr Ile Ala 
1               5                   10  


<210>  263
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103454D07-CDR2

<400>  263

Arg Ile Ser Ser Asp Asp Thr Ile Lys 
1               5                   


<210>  264
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103454D07-CDR3

<400>  264

Leu Ile Thr Pro Trp Thr Gly Asp Thr Arg Thr Tyr 
1               5                   10          


<210>  265
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALB00223

<400>  265

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala 
        115     


<210>  266
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALB00223 without C-terminal A

<400>  266

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  267
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALB00223-HSA-CDR1

<400>  267

Gly Phe Thr Phe Arg Ser Phe Gly Met Ser 
1               5                   10  


<210>  268
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH2-consensus Framework 1

<400>  268

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  269
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH2-consensus Framework 2

<400>  269

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  


<210>  270
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH2-consensus Framework 3

<400>  270

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Asn Ala 
        35                  


<210>  271
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH2-consensus Framework

<400>  271

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  272
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of FLAG-HIS6 peptide

<400>  272
gcggccgcag attataaaga tcatgatggc gattataaag atcatgatat tgattataaa       60

gatgatgatg ataaaggggc cgcacatcat catcatcatc at                         102


<210>  273
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F0103262B06

<400>  273
gaggtgcaat tggtggagtc tgggggaggt ttggtgcagc ctgggggctc tctgagactc       60

tcgtgtgctg ggtctacacg cacgtttagc acctatgcca tgggctggtt ccgccaggct      120

ccagggaggg agcgtgagtt tgtagcacat attaatttta gcggtagtag cacaaggtat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa tatgggatat      240

ctgcagatga atagcctgaa acctgaggac acggccgttt attattgtgc agcccggtgg      300

gtcgctggcc ctccgaggta tgactatgag tactggggcc aggggaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  274
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F0103262C02

<400>  274
gaggtgcaat tggtggagtc tgggggagga ttggtgcagg ctgggggctc tctgacactc       60

tcctgtgcag cctctggtct gcccttcgga ttgtatattc tgggctggat ccgccgggct      120

ccagggaagg agcgtgattt tgtagcagct attagccgga gtggtaggga cacggtttat      180

gcaaactccg tgaagggccg attcaccatc tccagagaca acgccaagaa catggtgtac      240

ctgcgaatgg acaatctgag accggaggac acggccgcat attactgtgc agtggactca      300

gtgccacgcg gaactcctac catcacagag tctgagtacg ccatctgggg ccaggggacc      360

ctggtcaccg tctcctca                                                    378


<210>  275
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F0103265A11

<400>  275
gaggtgcaat tggtggagtc tgggggaggc ttggtgcagc ctggagggtc tctgagactc       60

tcctgtgcag cctctggaat gctcttcaac gccaataccc agggctggta ccgccaggct      120

ccagggaagc agcgcgaatt ggtcgcattt atttttagtg gtggttacac aaactatgta      180

gactccgtga agggccgttt caccatctcc agagacaacg ccaagcgcac aatgtatctg      240

cagatgaaca gcctgaaacc tgaggactcg gccatctatt actgctcatt gagtcgctac      300

ttgggccagg ggaccctggt caccgtctcc tca                                   333


<210>  276
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F0103265B04

<400>  276
gaggtgcaat tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cccctagttt catcttcagc aacaattaca tggagtggta ccggcaggct      120

ccagggaagc agcgcgactg ggtcgcacgt attacaggtc gcggtaacac aaactatctg      180

gactccgtga agggccgatt caccatctcc agagacgacg ccaagaatac ggtgtatcta      240

gaaatcgaca gcctgaaacc tgaggacacg gccgtctatt actgtagtgc actctggtac      300

ggcgggcgcg catggggcaa agggaccctg gtcaccgtct cctca                      345


<210>  277
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F0103275B05

<400>  277
gaggtgcaat tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcttcaat atcaacagta tggcctggta tcgccgggct      120

ccagggaagc agcgcgaatt ggtcgcaagt agcaccaatg gtggtagtac aaactatgca      180

gactccgtga agggccgatt caccatctct agagacaacg ccaaacgggt gtatctgcaa      240

atgaacagcc tgacacctga ggacacggcc gtctattatt gtaatgcact gctacaaccg      300

tcgatttatg acattagtcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  278
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F0103362B08

<400>  278
gaggtgcaat tggtggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgtgcag cctctgtacg tcccttcagt acctcagcca tgggctggtt ccgccaggct      120

ccagagaagg agcgtgaggc tgtagcaggt attctgtgga atggtattgt cacatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa tgaagtatat      240

ctgcaaatga acaaactgaa acccgaggac acggccgttt attattgtgc attagataga      300

gattatggtg ggcgatcttt ttcggcatat gaatatgagt actggggcca ggggaccctg      360

gtcaccgtct cctca                                                       375


<210>  279
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F0103387G04

<400>  279
gaggtgcaat tggtggagtc tgggggaggc ttggcgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtcttcaat atcaacaaga tggcctggta ccgccgggct      120

ccagggaagc agcgcgaatt ggtcgcaagt gtcaccccta ctggtagtat aagttatact      180

gactccgtga agggccgatt caccatttct agagacggct ccaagcggtg gtctctacaa      240

atgaacagcc tgacacctga ggacacggcc gtctattact gtaacgcttt actacaaccg      300

gatagttatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  280
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F0103387G04

<400>  280
gaggtgcaat tggtggagtc tgggggaggc ttggtgcagg ctggggggtc actgagactc       60

tcctgtgacg cctctggaag gatcctccgt atcggctaca tgaggtggca ccgccagggt      120

gcagggaagc agcgcgagtt tgtcgcgcgt attactgatg atagtgctac agactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaaca acctgaatcc tgaggacacg gccgtctatt attgtgaggc gttggtgact      300

gcgagtgtac gtggtgggag tatacattct ggtacctatt ggggccgggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  281
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F0103454D07

<400>  281
gaggtgcaat tggtggagtc tgggggagga ttggtgcagc ctggaggatc acttagactg       60

tcctgtgtag cctccggggg catcatcaat atcaattaca ttgcctggta ccgccagact      120

ccagggaagc agcgcgactt ggtcgctcgt attagtagtg atgatacaat aaagtatggc      180

gactccgtga agggccgatt cgccatgtcc agagacaagg tcaagaatat ggtgcatcta      240

caaatgaaca gcctgactac cgaggacaca ggtgtctatg tctgttcagc cctcatcacg      300

ccttggacag gagacacccg gacctattgg ggccggggga ccctggtcac cgtctcctca      360


<210>  282
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F0103464B09

<400>  282
gaggtgcaat tggtggagtc tgggggagga ttggtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caacctctag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attctccatc tccagggaca acgccaagaa gatggtgact      240

ctgagaatga gcaatctgaa acctgaggac acaggggtct attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  283
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F0103464B09

<400>  283
gaggtgcaat tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcttcaat atcaaccgca tggcctggta tcgccgggct      120

ccagggaagc agcgcgaatt ggtcgcatat agcaccaatg gtggtgatac aaactatgca      180

gactccgtga agggccgatt caccatcagc agagacaacg ccaaacgggt gtatctgcaa      240

atgaacagcc tgacacctga ggacacggcc gtctattatt gtcgcgcact gctacaaccg      300

tcgatttatg acattagtcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  284
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301635

<400>  284
gaggtgcaat tggtggagtc tgggggaggc gttgtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcttcaat atcaacagta tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcaagt agcaccaatg gtggtagtac aaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaaacgggt gtatctgcaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattatt gtaatgcact gctacaaccg      300

tcgatttatg acattagtcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  285
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301636

<400>  285
gaggtgcaat tggtggagtc tgggggaggc gttgtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcttcaat atcaacagta tggcctggta tcgccgggct      120

ccagggaagc agcgcgaatt ggtcgcaagt agcaccaatg gtggtagtac aaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaaaaacgt gtatctgcaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattatt gtaatgcact gctacaaccg      300

tcgatttatg acattagtcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  286
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301637

<400>  286
gaggtgcaat tggtggagtc tgggggaggc gttgtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcttcaat atcaacagta tggcctggta tcgccgggct      120

ccagggaagc agcgcgaatt ggtcgcaagt agcaccaatg gtggtagtac aaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaaacgggt gtatctgcaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattatt gtaatgcact gctacaaccg      300

tcgatttatg acattagtcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  287
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301638

<400>  287
gaggtgcaat tggtggagtc tgggggaggc gttgtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcttcaat atcaacagta tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcaagt agcaccaatg gtggtagtac aaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaaaaacgt gtatctgcaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattatt gtaatgcact gctacaaccg      300

tcgatttatg acattagtcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  288
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301639

<400>  288
gaggtgcaat tggtggagtc tgggggaggc gttgtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcttcaat atcaacagta tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcaagt agcaccaatg gtggtagtac aaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaaacggac cgtgtatctg      240

caaatgaaca gcctgcgccc tgaggacacg gccctgtatt attgtaatgc actgctacaa      300

ccgtcgattt atgacattag tcgcacatat tggggccagg ggaccctggt caccgtctcc      360

tca                                                                    363


<210>  289
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301640

<400>  289
gaggtgcaat tggtggagtc tgggggaggc gttgtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcttcaat atcaacagta tggcctggta tcgccgggct      120

ccagggaagc agcgcgaatt ggtcgcaagt agcaccaatg gtggtagtac aaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaaacggac cgtgtatctg      240

caaatgaaca gcctgcgccc tgaggacacg gccctgtatt attgtaatgc actgctacaa      300

ccgtcgattt atgacattag tcgcacatat tggggccagg ggaccctggt caccgtctcc      360

tca                                                                    363


<210>  290
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301641

<400>  290
gaggtgcaat tggtggagtc tgggggaggc gttgtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcttcaat atcaacagta tggcctggta tcgccgggct      120

ccagggaagc agcgcgaatt ggtcgcaagt agcaccaatg gtggtagtac aaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaaaaacac cgtgtatctg      240

caaatgaaca gcctgcgccc tgaggacacg gccctgtatt attgtaatgc actgctacaa      300

ccgtcgattt atgacattag tcgcacatat tggggccagg ggaccctggt caccgtctcc      360

tca                                                                    363


<210>  291
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301642

<400>  291
gaggtgcaat tggtggagtc tgggggaggc gttgtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcttcaat atcaacagta tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcaagt agcaccaatg gtggtagtac aaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaaaaacac cgtgtatctg      240

caaatgaaca gcctgcgccc tgaggacacg gccctgtatt attgtaatgc actgctacaa      300

ccgtcgattt atgacattag tcgcacatat tggggccagg ggaccctggt caccgtctcc      360

tca                                                                    363


<210>  292
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301652

<400>  292
gaggtgcaat tggtggagtc tgggggaggc gttgtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcttcaat atcaaccgca tggcctggta tcgccgggct      120

ccagggaagc agcgcgaatt ggtcgcatat agcaccaatg gtggtgatac aaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaaaaacgt gtatctgcaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattatt gtcgcgcact gctacaaccg      300

tcgatttatg acattagtcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  293
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301653

<400>  293
gaggtgcaat tggtggagtc tgggggaggc gttgtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcttcaat atcaaccgca tggcctggta tcgccgggct      120

ccagggaagc agcgcgaatt ggtcgcatat agcaccaatg gtggtgatac aaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaaacgggt gtatctgcaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattatt gtcgcgcact gctacaaccg      300

tcgatttatg acattagtcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  294
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301654

<400>  294
gaggtgcaat tggtggagtc tgggggaggc gttgtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat agcaccaatg gtggtgatac aaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaaacgggt gtatctgcaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattatt gtcgcgcact gctacaaccg      300

tcgatttatg acattagtcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  295
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301655

<400>  295
gaggtgcaat tggtggagtc tgggggaggc gttgtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat agcaccaatg gtggtgatac aaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaaaaacgt gtatctgcaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattatt gtcgcgcact gctacaaccg      300

tcgatttatg acattagtcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  296
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301556

<400>  296
gaggtgcaat tggtggagtc tgggggaggc ttggtgcagg ctggggggtc actgagactc       60

tcctgtgctg cctctggaag aatcctccgt atcggctaca tgaggtggca ccgccagggt      120

gcagggaagc agcgcgagtt tgtcgcgcgt attactggtg gtagtgctac aggctatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaaca acctgaatcc tgaggacacg gccgtctatt attgtgaggc gttggtgact      300

gcgagtgtac gtggtgggag tatacattct ggaacctatt ggggccgggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  297
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301563

<400>  297
gaggtgcaat tggtggagtc tgggggaggc ttggtgcagg ctggggggtc actgagactc       60

tcctgtgctg cctctggaag aatcctccgt atcggctaca tgaggtggca ccgccagggt      120

gcagggaagc agcgcgagtt tgtcgcgcgt attactgatg atagtgctac aggctatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaaca acctgaatcc tgaggacacg gccgtctatt attgtgaggc gttggtgact      300

gcgagtgtac gtggtgggag tatacattct ggaacctatt ggggccgggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  298
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301849

<400>  298
gaggtgcaat tggtggagtc tgggggaggc gtggtgcagc ctggggggtc actgagactc       60

tcctgtgatg cctctggaag gatactccgt atcggctaca tgaggtggca ccgccagggt      120

gcagggaagc agcgcgagtt tgtcgcgcgt attactgatg atagtgctac agactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaact ccctgcgacc tgaggacacg gccctctatt attgtgaggc gttggtgact      300

gcgagtgtac gtggtgggag tatacattct ggaacctatt ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  299
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301850

<400>  299
gaggtgcaat tggtggagtc tgggggaggc gtcgtgcagc cgggggggtc actgagactc       60

tcctgtgcgg ccagcggaag gattctccgt atcggctaca tgaggtggta tcgccaggcg      120

ccggggaagc agcgcgagtt tgtcgcgcgt attactgatg atagtgctac aggttatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaaca gcctgcgccc tgaggacacg gccctgtatt attgtgaggc gttggtgact      300

gcgagtgtac gtggtgggag tatacattct ggcacctatt ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  300
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301643

<400>  300
gaggtgcaat tggtggagtc tgggggaggc gtggtgcagc ctggggggtc actgagactc       60

tcctgtgccg cctctggaag gatactccgt atcggctaca tgaggtggca ccgccagggt      120

gcagggaagc agcgcgagtt tgtcgcgcgt attactgatg atagtgctac agactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaact ccctgcgacc tgaggacacg gccctctatt attgtgaggc gttggtgact      300

gcgagtgtac gtggtgggag tatacattct ggaacctatt ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  301
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301644

<400>  301
gaggtgcaat tggtggagtc tgggggaggc gtggtgcagc ctggggggtc actgagactc       60

tcctgtgatg cctctggaag gatactccgt atcggctaca tgaggtggta tcgccagggt      120

gcagggaagc agcgcgagtt tgtcgcgcgt attactgatg atagtgctac agactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaact ccctgcgacc tgaggacacg gccctctatt attgtgaggc gttggtgact      300

gcgagtgtac gtggtgggag tatacattct ggaacctatt ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  302
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301645

<400>  302
gaggtgcaat tggtggagtc tgggggaggc gtggtgcagc ctggggggtc actgagactc       60

tcctgtgatg cctctggaag gatactccgt atcggctaca tgaggtggca ccgccaggct      120

gcagggaagc agcgcgagtt tgtcgcgcgt attactgatg atagtgctac agactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaact ccctgcgacc tgaggacacg gccctctatt attgtgaggc gttggtgact      300

gcgagtgtac gtggtgggag tatacattct ggaacctatt ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  303
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301646

<400>  303
gaggtgcaat tggtggagtc tgggggaggc gtggtgcagc ctggggggtc actgagactc       60

tcctgtgatg cctctggaag gatactccgt atcggctaca tgaggtggca ccgccagggt      120

ccagggaagc agcgcgagtt tgtcgcgcgt attactgatg atagtgctac agactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaact ccctgcgacc tgaggacacg gccctctatt attgtgaggc gttggtgact      300

gcgagtgtac gtggtgggag tatacattct ggaacctatt ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  304
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301647

<400>  304
gaggtgcaat tggtggagtc tgggggaggc gtggtgcagc ctggggggtc actgagactc       60

tcctgtgatg cctctggaag gatactccgt atcggctaca tgaggtggca ccgccagggt      120

gcagggaagc agcgcgagct tgtcgcgcgt attactgatg atagtgctac agactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaact ccctgcgacc tgaggacacg gccctctatt attgtgaggc gttggtgact      300

gcgagtgtac gtggtgggag tatacattct ggaacctatt ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  305
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301648

<400>  305
gaggtgcaat tggtggagtc tgggggaggc gtggtgcagc ctggggggtc actgagactc       60

tcctgtgatg cctctggaag gatactccgt atcggctaca tgaggtggca ccgccagggt      120

gcagggaagc agcgcgagtt tgtcgcgcgt attactgatg atagtgctac agactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaact ccctgcgacc tgaggacacg gccctctatt attgtaacgc gttggtgact      300

gcgagtgtac gtggtgggag tatacattct ggaacctatt ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  306
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301649

<400>  306
gaggtgcaat tggtggagtc tgggggaggc gtcgtgcagc cgggggggtc actgagactc       60

tcctgtgcgg ccagcggaag gattctccgt atcggctaca tgaggtggca ccgccaggcg      120

ccggggaagc agcgcgagtt tgtcgcgcgt attactgatg atagtgctac aggttatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaaca gcctgcgccc tgaggacacg gccctgtatt attgtgaggc gttggtgact      300

gcgagtgtac gtggtgggag tatacattct ggcacctatt ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  307
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302307

<400>  307
gaggtgcaat tggtggagtc tgggggaggc gtcgtgcagc cgggggggtc actgagactc       60

tcctgtgcgg ccagcggaag gattctccgt atcggctaca tgaggtggta tcgccaggcg      120

ccggggaagc agcgcgagtt tgtcgcgcgt attactgatg atagtgctac aggttatgca      180

gactccgtga agggccgatt caccatctcc agagacgcgg ccaagaacac ggtgtatctg      240

caaatgaaca gcctgcgccc tgaggacacg gccctgtatt attgtgaggc gttggtgact      300

gcgagtgtac gtggtgggag tatacattct ggcacctatt ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  308
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302308

<400>  308
gaggtgcaat tggtggagtc tgggggaggc gtcgtgcagc cgggggggtc actgagactc       60

tcctgtgcgg ccagcggaag gattctccgt atcggctaca tgaggtggta tcgccaggcg      120

ccggggaagc agcgcgagtt tgtcgcgcgt attactgatg atagtgctac aggttatgca      180

gactccgtga agggccgatt caccatctcc agagactatg ccaagaacac ggtgtatctg      240

caaatgaaca gcctgcgccc tgaggacacg gccctgtatt attgtgaggc gttggtgact      300

gcgagtgtac gtggtgggag tatacattct ggcacctatt ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  309
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302309

<400>  309
gaggtgcaat tggtggagtc tgggggaggc gtcgtgcagc cgggggggtc actgagactc       60

tcctgtgcgg ccagcggaag gattctccgt atcggctaca tgaggtggta tcgccaggcg      120

ccggggaagc agcgcgagtt tgtcgcgcgt attactgatg atagtgctac aggttatgca      180

gactccgtga agggccgatt caccatctcc agagaccagg ccaagaacac ggtgtatctg      240

caaatgaaca gcctgcgccc tgaggacacg gccctgtatt attgtgaggc gttggtgact      300

gcgagtgtac gtggtgggag tatacattct ggcacctatt ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  310
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302391

<400>  310
gaggtgcaat tggtggagtc tggtggtgga gttgttcaac ccggtggttc tttgagattg       60

tcttgcgccg cttccggtag aatcttgcgt atcggttaca tgcgttggta tagacaagct      120

cccggtaagc aaagagagtt cgtcgccaga atcaccggag gttctgctac tggttatgct      180

gattccgtca agggaagatt taccatctcc agagacaacg ctaagaacac tgtttatttg      240

caaatgaact ccttgagacc cgaagatacc gctttgtact actgcgaggc tttggtcact      300

gcttccgtta gaggaggatc tatccactcc ggtacttact ggggtcaagg aaccctggtc      360

accgtctcct ca                                                          372


<210>  311
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302392

<400>  311
gaggtgcaat tggtggagtc tggtggtggt gttgttcagc ccggtggttc cttgagattg       60

tcttgtgctg cttccggtag aatcttgaga atcggttaca tgagatggta cagacaagcc      120

cccggtaagc agagagagtt cgtcgccaga atcactggag gatctgctac tggttacgct      180

gactccgtca agggaagatt caccatctcc agagatcaag ctaagaacac cgtctacttg      240

cagatgaact ccttgagacc agaggacacc gctttgtact actgtgaggc tttagttact      300

gcttccgtta gaggtggttc cattcactct ggtacttact ggggtcaagg aaccctggtc      360

accgtctcct ca                                                          372


<210>  312
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301868

<400>  312
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caaccagcag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attcaccatc tccagggaca acgccaagaa gatggtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  313
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301869

<400>  313
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caaccagcag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  314
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301870

<400>  314
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caaccagcag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attcaccatc tccagggaca acgccaagaa gatggtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcaa cttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  315
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301871

<400>  315
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgaccagcag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attcaccatc tccagggaca acgccaagaa gatggtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  316
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301872

<400>  316
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caagcagcag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attcaccatc tccagggaca acgccaagaa gatggtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  317
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301873

<400>  317
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caaccagcag agctttcatc agggacgttt tcacgggctg gtatcgccag      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attcaccatc tccagggaca acgccaagaa gatggtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  318
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301874

<400>  318
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caaccagcag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gcgcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attcaccatc tccagggaca acgccaagaa gatggtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  319
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301875

<400>  319
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caaccagcag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa gatggtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  320
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301876

<400>  320
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caaccagcag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg tgaagggccg attcaccatc tccagggaca acgccaagaa gatggtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  321
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301877

<400>  321
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caaccagcag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attcaccatc tccagggaca acgccaagaa catggtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  322
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301892

<400>  322
gaggtgcaat tggtggagtc tgggggagga ttggtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caacctctag agctttcatc agggaccttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attctccatc tccagggaca acgccaagaa gatggtgact      240

ctgagaatga gcaatctgaa acctgaggac acaggggtct attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  323
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301893

<400>  323
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caaccagcag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga agcagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attcaccatc tccagggaca acgccaagaa gatggtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  324
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301932

<400>  324
gaggtgcaat tggtggagtc tgggggagga gttgtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caacctccag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attctccatc tccagggaca acgccaagaa gatggtgact      240

ctgagaatga gcaatctgcg ccctgaggac acagggctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  325
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301933

<400>  325
gaggtgcaat tggtggagtc tgggggagga gttgtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caacctccag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attcaccatc tccagggaca acgccaagaa gatggtgact      240

ctgagaatga gcaatctgcg ccctgaggac acagggctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  326
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301934

<400>  326
gaggtgcaat tggtggagtc tgggggagga gttgtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caacctccag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attctccatc tccagggaca acgccaagaa gaccgtgact      240

ctgagaatga gcaatctgcg ccctgaggac acagggctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  327
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301935

<400>  327
gaggtgcaat tggtggagtc tgggggagga gttgtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caacctccag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attctccatc tccagggaca acgccaagaa gatggtgtat      240

ctgagaatga gcaatctgcg ccctgaggac acagggctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  328
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301936

<400>  328
gaggtgcaat tggtggagtc tgggggagga gttgtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caacctccag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attctccatc tccagggaca acgccaagaa gatggtgact      240

ctgcaaatga gcaatctgcg ccctgaggac acagggctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  329
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301937

<400>  329
gaggtgcaat tggtggagtc tgggggagga gttgtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caacctccag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attctccatc tccagggaca acgccaagaa gatggtgact      240

ctgagaatga acaatctgcg ccctgaggac acagggctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  330
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301938

<400>  330
gaggtgcaat tggtggagtc tgggggagga gttgtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caacctccag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attctccatc tccagggaca acgccaagaa gatggtgact      240

ctgagaatga gcagcctgcg ccctgaggac acagggctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  331
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301939

<400>  331
gaggtgcaat tggtggagtc tgggggagga gttgtgcagc ctggaggatc actaagactg       60

tcctgtgcaa caacctccag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gttcccggga aggagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacttcg cgaagggccg attctccatc tccagggaca acgccaagaa gatggtgact      240

ctgagaatga gcaatctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcaata ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  332
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302333

<400>  332
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagcagcag acagttcatc agggacgttt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttaca atgaaggtaa cacaaattat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  333
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302334

<400>  333
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagcagcag acagttcatc agggacgttt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttaca atgaaggtaa cacacagtat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  334
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302335

<400>  334
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagcagcag acagttcatc agggacgttt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaagcggtaa cacacagtat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  335
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302336

<400>  335
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag acagttcatc agggacgttt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttaca atgaaggtaa cacacagtat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  336
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302337

<400>  336
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag acagttcatc agggacgttt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaggcggtaa cacacagtat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  337
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302338

<400>  337
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaagcggtaa cacacagtat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  338
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302339

<400>  338
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaggcggtaa cacacagtat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  339
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302340

<400>  339
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag agctttcatc agggacctgt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaagcggtaa cacaaattat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  340
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302341

<400>  340
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagcagcag acagttcatc agggacgttt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttaca atgaaggtaa cacaaattat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  341
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302342

<400>  341
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagcagcag acagttcatc agggacgttt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttaca atgaaggtaa cacacagtat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  342
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302343

<400>  342
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagcagcag acagttcatc agggacgttt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaagcggtaa cacacagtat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  343
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302344

<400>  343
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag acagttcatc agggacgttt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttaca atgaaggtaa cacacagtat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  344
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302345

<400>  344
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag acagttcatc agggacgttt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaggcggtaa cacacagtat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  345
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302346

<400>  345
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag agctttcatc agggacgttt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaagcggtaa cacacagtat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  346
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302347

<400>  346
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag agctttcatc agggacgttt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaggcggtaa cacacagtat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  347
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302348

<400>  347
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag agctttcatc agggacctgt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaagcggtaa cacaaattat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  348
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302349

<400>  348
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagcagcag acagttcatc agggacgttt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttaca atgaaggtaa cacaaattat      180

gcagacagcg tgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  349
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302350

<400>  349
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagcagcag acagttcatc agggacgttt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttaca atgaaggtaa cacacagtat      180

gcagacagcg tgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  350
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302351

<400>  350
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagcagcag acagttcatc agggacgttt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaagcggtaa cacacagtat      180

gcagacagcg tgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  351
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302352

<400>  351
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag acagttcatc agggacgttt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttaca atgaaggtaa cacacagtat      180

gcagacagcg tgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  352
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302353

<400>  352
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag acagttcatc agggacgttt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaggcggtaa cacacagtat      180

gcagacagcg tgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  353
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302354

<400>  353
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaagcggtaa cacacagtat      180

gcagacagcg tgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  354
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302355

<400>  354
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaggcggtaa cacacagtat      180

gcagacagcg tgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  355
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302356

<400>  355
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag agctttcatc agggacctgt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaagcggtaa cacaaattat      180

gcagacagcg tgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  356
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302357

<400>  356
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagcagcag acagttcatc agggacgttt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttaca atgaaggtaa cacaaattat      180

gcagacagcg tgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  357
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302358

<400>  357
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagcagcag acagttcatc agggacgttt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttaca atgaaggtaa cacacagtat      180

gcagacagcg tgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  358
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302359

<400>  358
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagcagcag acagttcatc agggacgttt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaagcggtaa cacacagtat      180

gcagacagcg tgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  359
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302360

<400>  359
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag acagttcatc agggacgttt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttaca atgaaggtaa cacacagtat      180

gcagacagcg tgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  360
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302361

<400>  360
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag acagttcatc agggacgttt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaggcggtaa cacacagtat      180

gcagacagcg tgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  361
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302362

<400>  361
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag agctttcatc agggacgttt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaagcggtaa cacacagtat      180

gcagacagcg tgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  362
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302363

<400>  362
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag agctttcatc agggacgttt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaggcggtaa cacacagtat      180

gcagacagcg tgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  363
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302364

<400>  363
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagccatag agctttcatc agggacctgt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttacg aaagcggtaa cacaaattat      180

gcagacagcg tgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  364
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302365

<400>  364
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagcagcag agctttcatc agggacgttt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  365
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302366

<400>  365
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagcagcag agctttcatc agggacgttt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  366
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302367

<400>  366
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagcagcag agctttcatc agggacgttt tcacgggctg gtatcgccag      120

gcgcccggga agcagcgcga attggtcgct cgcatttaca atggcggtaa cacaaattat      180

gcagacagcg tgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  367
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302368

<400>  367
gaggtgcaat tggtggagtc tgggggagga gtggtgcagc ctggaggatc actaagactg       60

tcctgtgcag cgagcagcag acagttcatc agggacgttt tcacgggctg gtatcgccgg      120

gcgcccggga agcagcgcga attggtcgct cgcatttaca atgaaggtaa cacaaattat      180

gcagacagcg cgaagggccg attcaccatc tccagggaca acgccaagaa aaccgtgtat      240

ctgcaaatga acagcctgcg ccctgaggac acagcgctgt attactgcct tttttcgggt      300

acaatcagca ctggcagaga gtatcggtct ggagactact ggggccaggg gaccctggtc      360

accgtctcct ca                                                          372


<210>  368
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301656

<400>  368
gaggtgcaat tggtggagtc tgggggaggc ttggcgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtctttaat atcaaccgca tggcctggta tcgccgggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatact      180

gactccgtga agggccgatt caccatttct agggacggct ccaagcggtg gtctctacaa      240

atgaacagcc tgacacctga ggacacggcc gtctattact gtcgcgcttt actacaaccg      300

gatagttatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  369
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301840

<400>  369
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatact      180

gactccgtga agggccgatt caccatttct cgcgacggct ccaagcggac ctggtctcta      240

caaatgaaca gcctgcgccc tgaggacacg gccctgtatt actgtcgcgc tttactacaa      300

ccggatagtt attctaatac gcgcacatat tggggccagg ggaccctggt caccgtctcc      360

tca                                                                    363


<210>  370
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301841

<400>  370
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatact      180

gactccgtga agggccgatt caccatttct cgcgacggct ccaagcggtg gtctctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatagttatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  371
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301842

<400>  371
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacggct ccaagcggtg gtctctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatagttatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  372
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301843

<400>  372
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatact      180

gactccgtga agggccgatt caccatttct cgcgacaact ccaagcggtg gtctctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatagttatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  373
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301844

<400>  373
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatact      180

gactccgtga agggccgatt caccatttct cgcgacggct ccaagaactg gtctctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatagttatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  374
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301845

<400>  374
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatact      180

gactccgtga agggccgatt caccatttct cgcgacggct ccaagcgggt ctctctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatagttatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  375
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301846

<400>  375
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatact      180

gactccgtga agggccgatt caccatttct cgcgacggct ccaagcggtg gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatagttatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  376
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301847

<400>  376
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacaact ccaagaacgt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatagttatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  377
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301848

<400>  377
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacaact ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatagttatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  378
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301865

<400>  378
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacggct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatagttatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  379
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010301866

<400>  379
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacggct ccaagaacgt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatagttatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  380
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302310

<400>  380
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacgcgt ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

cgccgctatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  381
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302311

<400>  381
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgaccgct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

cgccgctatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  382
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302312

<400>  382
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacggct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatagttatt ctattacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  383
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302313

<400>  383
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacgcgt ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccccga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatagttatt ctattacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  384
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302314

<400>  384
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgaccgct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatagttatt ctattacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  385
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302315

<400>  385
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacggct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

cgcagttatt ctattacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  386
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302316

<400>  386
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacgcgt ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

cgcagttatt ctattacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  387
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302317

<400>  387
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgaccgct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

cgcagttatt ctattacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  388
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302318

<400>  388
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacggct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatcgctatt ctattacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  389
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302319

<400>  389
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacgcgt ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatcgctatt ctattacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  390
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302320

<400>  390
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacgcgt ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatagttatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  391
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302321

<400>  391
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgaccgct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatcgctatt ctattacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  392
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302322

<400>  392
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacggct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

cgccgctatt ctattacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  393
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302323

<400>  393
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacgcgt ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

cgccgctatt ctattacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  394
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302324

<400>  394
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgaccgct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

cgccgctatt ctattacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  395
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302325

<400>  395
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgaccgct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatagttatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  396
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302326

<400>  396
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacggct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

cgcagttatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  397
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302327

<400>  397
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacgcgt ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

cgcagttatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  398
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302328

<400>  398
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgaccgct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

cgcagttatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  399
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302329

<400>  399
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacggct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatcgctatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  400
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302330

<400>  400
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacgcgt ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatcgctatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  401
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302331

<400>  401
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgaccgct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatcgctatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  402
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302332

<400>  402
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgacggct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

cgccgctatt ctaatacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  403
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302370

<400>  403
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgaccgct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

agcagttatt ctattacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  404
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302371

<400>  404
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgaccgct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

aacgtgtatt ctattacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  405
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302372

<400>  405
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcgaccgct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

gatgtgtatt ctattacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  406
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302383

<400>  406
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcggtggct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

agcagttatt ctggcacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  407
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302384

<400>  407
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgcggtggct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

agcagttatt ctattacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  408
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302385

<400>  408
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgccagggct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

agcagttatt ctggcacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  409
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of F010302386

<400>  409
gaggtgcaat tggtggagtc tgggggaggc gtggttcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggacc cgtgttcaat atcaaccgca tggcctggta tcgccaggct      120

ccagggaagc agcgcgaatt ggtcgcatat gtcaccccta ctggtgatat aagttatgcg      180

gactccgtga agggccgatt caccatttct cgccagggct ccaagcgggt gtatctacaa      240

atgaacagcc tgcgccctga ggacacggcc ctgtattact gtcgcgcttt actacaaccg      300

agcagttatt ctattacgcg cacatattgg ggccagggga ccctggtcac cgtctcctca      360


<210>  410
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103240B04 (No tag)

<400>  410

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Gly Arg Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Ala Met Thr Tyr Tyr Ala Asp Asp Gly Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Tyr Thr Trp Asp Tyr Phe Lys Tyr Asp Gln Val Arg Ala Tyr Arg Gly 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  411
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103478E09 (No tag)

<400>  411

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Thr Leu 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Asn Gly Asn Asn Ser Ala Thr Gly Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Thr Lys Ser Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ile Ser Thr Pro Ser Ala Ser His Pro Tyr Val Arg Lys Glu 
            100                 105                 110         


Ser Tyr Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  412
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103492E09 (No tag)

<400>  412

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Lys Ser Ile Leu Ser Phe Ala 
            20                  25                  30          


Tyr Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Ala Ile Gly Gly Ala Thr Ser Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ala Pro Ala Gly Gln Tyr Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  413
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103500E03 (No tag)

<400>  413

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Tyr Ile Ser Trp Ser Gly Ser Thr Arg Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr His Cys Ala 
                85                  90                  95      


Ala Gly Thr Ala Gly Ile Ile Ser Ser Arg Pro Glu Thr Tyr Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  414
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103505D08 (No tag)

<400>  414

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Thr Ser Gly Arg Thr Ser Asp Leu Ser 
            20                  25                  30          


Thr Met Asn Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Arg Arg Gly Ser Thr Tyr Tyr Ala Glu Ser Val Lys 
    50                  55                  60                  


Glu Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asn Tyr Tyr Cys Thr 
                85                  90                  95      


Ala Ala Ser Glu Met Gly Tyr His Tyr Arg Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  415
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103495F09 (No tag)

<400>  415

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ser 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Arg Ala Leu Ser Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Ser Arg Ser Gly Ile Thr Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Arg Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Leu Cys 
                85                  90                  95      


Ala Ala Asp Ala Ser Thr Asn Pro Ala Gly Tyr Tyr Leu Arg Asn Arg 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  416
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103240B04-CDR1

<400>  416

Gly Gly Thr Gly Arg Arg Tyr Ala Met Gly Trp 
1               5                   10      


<210>  417
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103240B04-CDR2

<400>  417

Ala Ile Arg Trp Ser Ala Met Thr Tyr 
1               5                   


<210>  418
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103240B04-CDR3

<400>  418

Thr Trp Asp Tyr Phe Lys Tyr Asp Gln Val Arg Ala Tyr Arg Gly 
1               5                   10                  15  


<210>  419
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103478E09-CDR1

<400>  419

Gly Arg Ala Phe Ser Thr Leu Ala Met Gly 
1               5                   10  


<210>  420
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103478E09-CDR2

<400>  420

Ile Ser Arg Asn Gly Asn Asn Ser 
1               5               


<210>  421
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103478E09-CDR3

<400>  421

Ile Ser Thr Pro Ser Ala Ser His Pro Tyr Val Arg Lys Glu Ser Tyr 
1               5                   10                  15      


Arg Tyr 
        


<210>  422
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103492E09-CDR1

<400>  422

Lys Ser Ile Leu Ser Phe Ala Tyr Met Arg 
1               5                   10  


<210>  423
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103492E09-CDR2

<400>  423

Ser Ile Ala Ile Gly Gly Ala Thr Ser 
1               5                   


<210>  424
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103492E09-CDR3

<400>  424

Pro Ala Gly Gln Tyr Arg 
1               5       


<210>  425
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103500E03-CDR1

<400>  425

Gly Arg Thr Phe Ser Arg Tyr Gln Met Gly 
1               5                   10  


<210>  426
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103500E03-CDR2

<400>  426

Tyr Ile Ser Trp Ser Gly Ser Thr Arg 
1               5                   


<210>  427
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103500E03-CDR3

<400>  427

Gly Thr Ala Gly Ile Ile Ser Ser Arg Pro Glu Thr Tyr Asp Ser 
1               5                   10                  15  


<210>  428
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103505D08-CDR1

<400>  428

Gly Arg Thr Ser Asp Leu Ser Thr Met Asn 
1               5                   10  


<210>  429
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103505D08-CDR2

<400>  429

Arg Ile Thr Arg Arg Gly Ser Thr Tyr 
1               5                   


<210>  430
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103505D08-CDR3

<400>  430

Ala Ser Glu Met Gly Tyr His Tyr Arg 
1               5                   


<210>  431
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103495F09-CDR1

<400>  431

Gly Arg Ala Leu Ser Thr Tyr Ala Met Gly 
1               5                   10  


<210>  432
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103495F09-CDR2

<400>  432

Arg Ile Ser Arg Ser Gly Ile Thr Thr 
1               5                   


<210>  433
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103495F09-CDR3

<400>  433

Asp Ala Ser Thr Asn Pro Ala Gly Tyr Tyr Leu Arg Asn Arg Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  434
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F103275B05(N93R)

<400>  434

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  435
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103275B05 (E1D,N93R)

<400>  435

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  436
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103478E09 (L108Q)

<400>  436

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Thr Leu 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Asn Gly Asn Asn Ser Ala Thr Gly Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Thr Lys Ser Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ile Ser Thr Pro Ser Ala Ser His Pro Tyr Val Arg Lys Glu 
            100                 105                 110         


Ser Tyr Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  437
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103505D08 (L108Q)

<400>  437

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Thr Ser Gly Arg Thr Ser Asp Leu Ser 
            20                  25                  30          


Thr Met Asn Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Arg Arg Gly Ser Thr Tyr Tyr Ala Glu Ser Val Lys 
    50                  55                  60                  


Glu Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asn Tyr Tyr Cys Thr 
                85                  90                  95      


Ala Ala Ser Glu Met Gly Tyr His Tyr Arg Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  438
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103500E03 (P14A,L108Q)

<400>  438

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Tyr Ile Ser Trp Ser Gly Ser Thr Arg Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr His Cys Ala 
                85                  90                  95      


Ala Gly Thr Ala Gly Ile Ile Ser Ser Arg Pro Glu Thr Tyr Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  439
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302375:F0103275B05(E1D,N93R)-50GS-F0103478E09(L108Q)-FLAG3-HI
       S6

<400>  439

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                165                 170                 175     


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
            180                 185                 190         


Ala Ala Ser Gly Arg Ala Phe Ser Thr Leu Ala Met Gly Trp Phe Arg 
        195                 200                 205             


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Asn 
    210                 215                 220                 


Gly Asn Asn Ser Ala Thr Gly Asp Ser Leu Lys Gly Arg Phe Thr Ile 
225                 230                 235                 240 


Ser Arg Asp Ser Thr Lys Ser Thr Val Phe Leu Gln Met Asn Thr Leu 
                245                 250                 255     


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ile Ser Thr Pro 
            260                 265                 270         


Ser Ala Ser His Pro Tyr Val Arg Lys Glu Ser Tyr Arg Tyr Trp Gly 
        275                 280                 285             


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ala Ala Asp Tyr Lys Asp 
    290                 295                 300                 


His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp 
305                 310                 315                 320 


Asp Lys Gly Ala Ala His His His His His His 
                325                 330     


<210>  440
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302377:F0103275B05(E1D,N93R)-50GS-F0103492E09-FLAG3-HIS6

<400>  440

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                165                 170                 175     


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
            180                 185                 190         


Ala Ala Ser Lys Ser Ile Leu Ser Phe Ala Tyr Met Arg Trp Tyr Arg 
        195                 200                 205             


Gln Ala Pro Gly Lys Gln Arg Glu Phe Val Ala Ser Ile Ala Ile Gly 
    210                 215                 220                 


Gly Ala Thr Ser Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
225                 230                 235                 240 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
                245                 250                 255     


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser Ala Pro Ala Gly Gln Tyr 
            260                 265                 270         


Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ala Ala Asp Tyr 
        275                 280                 285             


Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp 
    290                 295                 300                 


Asp Asp Asp Lys Gly Ala Ala His His His His His His 
305                 310                 315         


<210>  441
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302378:F0103275B05(E1D,N93R)-50GS-F0103495F09-FLAG3-HIS6

<400>  441

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                165                 170                 175     


Ser Gly Gly Gly Leu Val Gln Ala Gly Ser Ser Leu Ser Leu Ser Cys 
            180                 185                 190         


Ala Ala Ser Gly Arg Ala Leu Ser Thr Tyr Ala Met Gly Trp Phe Arg 
        195                 200                 205             


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Arg Ile Ser Arg Ser 
    210                 215                 220                 


Gly Ile Thr Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile 
225                 230                 235                 240 


Ser Arg Asp Arg Ala Lys Asp Thr Val Tyr Leu Gln Met Asn Ser Leu 
                245                 250                 255     


Lys Pro Glu Asp Thr Ala Ile Tyr Leu Cys Ala Ala Asp Ala Ser Thr 
            260                 265                 270         


Asn Pro Ala Gly Tyr Tyr Leu Arg Asn Arg Tyr Asp Tyr Trp Gly Gln 
        275                 280                 285             


Gly Thr Leu Val Thr Val Ser Ser Gly Ala Ala Asp Tyr Lys Asp His 
    290                 295                 300                 


Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp 
305                 310                 315                 320 


Lys Gly Ala Ala His His His His His His 
                325                 330 


<210>  442
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302379:F0103275B05(E1D,N93R)-50GS-F0103500E03(P14A,L108Q)-FLA
       G3-HIS6

<400>  442

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                165                 170                 175     


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
            180                 185                 190         


Ala Ala Ser Gly Arg Thr Phe Ser Arg Tyr Gln Met Gly Trp Phe Arg 
        195                 200                 205             


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Tyr Ile Ser Trp Ser 
    210                 215                 220                 


Gly Ser Thr Arg Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
225                 230                 235                 240 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
                245                 250                 255     


Pro Glu Asp Thr Ala Val Tyr His Cys Ala Ala Gly Thr Ala Gly Ile 
            260                 265                 270         


Ile Ser Ser Arg Pro Glu Thr Tyr Asp Ser Trp Gly Gln Gly Thr Gln 
        275                 280                 285             


Val Thr Val Ser Ser Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp 
    290                 295                 300                 


Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala 
305                 310                 315                 320 


Ala His His His His His His 
                325         


<210>  443
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302380:F0103275B05(E1D,N93R)-50GS-F0103505D08(L108Q)-FLAG3-HI
       S6

<400>  443

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                165                 170                 175     


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
            180                 185                 190         


Val Thr Ser Gly Arg Thr Ser Asp Leu Ser Thr Met Asn Trp Phe Arg 
        195                 200                 205             


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Arg Ile Thr Arg Arg 
    210                 215                 220                 


Gly Ser Thr Tyr Tyr Ala Glu Ser Val Lys Glu Arg Phe Ile Ile Ser 
225                 230                 235                 240 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
                245                 250                 255     


Pro Glu Asp Thr Ala Asn Tyr Tyr Cys Thr Ala Ala Ser Glu Met Gly 
            260                 265                 270         


Tyr His Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ala 
        275                 280                 285             


Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
    290                 295                 300                 


Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His His His 
305                 310                 315                 320 


<210>  444
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010300191:F0103275B05-50GS-F0103240B04-FLAG3-HIS6

<400>  444

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                165                 170                 175     


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
            180                 185                 190         


Ala Ala Ser Gly Gly Thr Gly Arg Arg Tyr Ala Met Gly Trp Phe Arg 
        195                 200                 205             


Gln Ala Pro Gly Lys Glu Arg Glu Ile Val Ala Ala Ile Arg Trp Ser 
    210                 215                 220                 


Ala Met Thr Tyr Tyr Ala Asp Asp Gly Lys Gly Arg Phe Thr Ile Ser 
225                 230                 235                 240 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
                245                 250                 255     


Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Tyr Thr Trp Asp Tyr Phe 
            260                 265                 270         


Lys Tyr Asp Gln Val Arg Ala Tyr Arg Gly Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp 
    290                 295                 300                 


Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala 
305                 310                 315                 320 


Ala His His His His His His 
                325         


<210>  445
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302375 (No Tag) 
       :F0103275B05(E1D,N93R)-50GS-F0103478E09(L108Q)

<400>  445

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                165                 170                 175     


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
            180                 185                 190         


Ala Ala Ser Gly Arg Ala Phe Ser Thr Leu Ala Met Gly Trp Phe Arg 
        195                 200                 205             


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Asn 
    210                 215                 220                 


Gly Asn Asn Ser Ala Thr Gly Asp Ser Leu Lys Gly Arg Phe Thr Ile 
225                 230                 235                 240 


Ser Arg Asp Ser Thr Lys Ser Thr Val Phe Leu Gln Met Asn Thr Leu 
                245                 250                 255     


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ile Ser Thr Pro 
            260                 265                 270         


Ser Ala Ser His Pro Tyr Val Arg Lys Glu Ser Tyr Arg Tyr Trp Gly 
        275                 280                 285             


Gln Gly Thr Gln Val Thr Val Ser Ser 
    290                 295         


<210>  446
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302377 (No Tag):F0103275B05(E1D,N93R)-50GS-F0103492E09

<400>  446

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                165                 170                 175     


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
            180                 185                 190         


Ala Ala Ser Lys Ser Ile Leu Ser Phe Ala Tyr Met Arg Trp Tyr Arg 
        195                 200                 205             


Gln Ala Pro Gly Lys Gln Arg Glu Phe Val Ala Ser Ile Ala Ile Gly 
    210                 215                 220                 


Gly Ala Thr Ser Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
225                 230                 235                 240 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
                245                 250                 255     


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser Ala Pro Ala Gly Gln Tyr 
            260                 265                 270         


Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280             


<210>  447
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302378 (No Tag):F0103275B05(E1D,N93R)-50GS-F0103495F09

<400>  447

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                165                 170                 175     


Ser Gly Gly Gly Leu Val Gln Ala Gly Ser Ser Leu Ser Leu Ser Cys 
            180                 185                 190         


Ala Ala Ser Gly Arg Ala Leu Ser Thr Tyr Ala Met Gly Trp Phe Arg 
        195                 200                 205             


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Arg Ile Ser Arg Ser 
    210                 215                 220                 


Gly Ile Thr Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile 
225                 230                 235                 240 


Ser Arg Asp Arg Ala Lys Asp Thr Val Tyr Leu Gln Met Asn Ser Leu 
                245                 250                 255     


Lys Pro Glu Asp Thr Ala Ile Tyr Leu Cys Ala Ala Asp Ala Ser Thr 
            260                 265                 270         


Asn Pro Ala Gly Tyr Tyr Leu Arg Asn Arg Tyr Asp Tyr Trp Gly Gln 
        275                 280                 285             


Gly Thr Leu Val Thr Val Ser Ser 
    290                 295     


<210>  448
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302379 (No 
       Tag):F0103275B05(E1D,N93R)-50GS-F0103500E03(P14A,L108Q)

<400>  448

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                165                 170                 175     


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
            180                 185                 190         


Ala Ala Ser Gly Arg Thr Phe Ser Arg Tyr Gln Met Gly Trp Phe Arg 
        195                 200                 205             


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Tyr Ile Ser Trp Ser 
    210                 215                 220                 


Gly Ser Thr Arg Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
225                 230                 235                 240 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
                245                 250                 255     


Pro Glu Asp Thr Ala Val Tyr His Cys Ala Ala Gly Thr Ala Gly Ile 
            260                 265                 270         


Ile Ser Ser Arg Pro Glu Thr Tyr Asp Ser Trp Gly Gln Gly Thr Gln 
        275                 280                 285             


Val Thr Val Ser Ser 
    290             


<210>  449
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010302380 (No Tag):F0103275B05(E1D,N93R)-50GS-F0103505D08(L108Q)

<400>  449

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                165                 170                 175     


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
            180                 185                 190         


Val Thr Ser Gly Arg Thr Ser Asp Leu Ser Thr Met Asn Trp Phe Arg 
        195                 200                 205             


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Arg Ile Thr Arg Arg 
    210                 215                 220                 


Gly Ser Thr Tyr Tyr Ala Glu Ser Val Lys Glu Arg Phe Ile Ile Ser 
225                 230                 235                 240 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
                245                 250                 255     


Pro Glu Asp Thr Ala Asn Tyr Tyr Cys Thr Ala Ala Ser Glu Met Gly 
            260                 265                 270         


Tyr His Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        275                 280                 285     


<210>  450
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010300191 (No Tag):F0103275B05-50GS-F0103240B04

<400>  450

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                165                 170                 175     


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
            180                 185                 190         


Ala Ala Ser Gly Gly Thr Gly Arg Arg Tyr Ala Met Gly Trp Phe Arg 
        195                 200                 205             


Gln Ala Pro Gly Lys Glu Arg Glu Ile Val Ala Ala Ile Arg Trp Ser 
    210                 215                 220                 


Ala Met Thr Tyr Tyr Ala Asp Asp Gly Lys Gly Arg Phe Thr Ile Ser 
225                 230                 235                 240 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
                245                 250                 255     


Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Tyr Thr Trp Asp Tyr Phe 
            260                 265                 270         


Lys Tyr Asp Gln Val Arg Ala Tyr Arg Gly Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser 
    290             


<210>  451
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103PMP478E09

<400>  451

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Thr Leu 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Asn Gly Asn Asn Ser Ala Thr Gly Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Thr Lys Ser Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ile Ser Thr Pro Ser Ala Ser His Pro Tyr Val Arg Lys Glu 
            100                 105                 110         


Ser Tyr Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile 
    130                 135                 140                 


Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His His 
145                 150                 155                 160 


His Lys Ala Ala Gly Gly Gly Gly Gly 
                165                 


<210>  452
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103PMP492E09

<400>  452

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Lys Ser Ile Leu Ser Phe Ala 
            20                  25                  30          


Tyr Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Ala Ile Gly Gly Ala Thr Ser Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ala Pro Ala Gly Gln Tyr Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His 
        115                 120                 125             


Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His 
    130                 135                 140                 


His His His Lys Ala Ala Gly Gly Gly Gly Gly 
145                 150                 155 


<210>  453
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103PMP495F09

<400>  453

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ser 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Arg Ala Leu Ser Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Ser Arg Ser Gly Ile Thr Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Arg Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Leu Cys 
                85                  90                  95      


Ala Ala Asp Ala Ser Thr Asn Pro Ala Gly Tyr Tyr Leu Arg Asn Arg 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala 
        115                 120                 125             


Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
    130                 135                 140                 


Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His His His 
145                 150                 155                 160 


Lys Ala Ala Gly Gly Gly Gly Gly 
                165             


<210>  454
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103PMP500E03

<400>  454

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gln Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Tyr Ile Ser Trp Ser Gly Ser Thr Arg Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr His Cys Ala 
                85                  90                  95      


Ala Gly Thr Ala Gly Ile Ile Ser Ser Arg Pro Glu Thr Tyr Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Asp Tyr 
        115                 120                 125             


Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp 
    130                 135                 140                 


Asp Asp Asp Lys Gly Ala Ala His His His His His His Lys Ala Ala 
145                 150                 155                 160 


<210>  455
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F0103PMP505D08

<400>  455

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Thr Ser Gly Arg Thr Ser Asp Leu Ser 
            20                  25                  30          


Thr Met Asn Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Arg Arg Gly Ser Thr Tyr Tyr Ala Glu Ser Val Lys 
    50                  55                  60                  


Glu Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asn Tyr Tyr Cys Thr 
                85                  90                  95      


Ala Ala Ser Glu Met Gly Tyr His Tyr Arg Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr 
        115                 120                 125             


Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala 
    130                 135                 140                 


His His His His His His Lys Ala Ala Gly Gly Gly Gly Gly 
145                 150                 155             


<210>  456
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding F0103240B04 (No tag)

<400>  456

Ala Thr Gly Ala Ala Ala Ala Ala Gly Ala Cys Cys Gly Cys Thr Ala 
1               5                   10                  15      


Thr Cys Gly Cys Gly Ala Thr Thr Gly Cys Ala Gly Thr Gly Gly Cys 
            20                  25                  30          


Ala Cys Thr Gly Gly Cys Thr Gly Gly Thr Thr Thr Gly Gly Cys Cys 
        35                  40                  45              


Ala Cys Cys Gly Thr Gly Gly Cys Cys Cys Ala Gly Gly Cys Cys Gly 
    50                  55                  60                  


Ala Gly Gly Thr Gly Cys Ala Ala Thr Thr Gly Gly Thr Gly Gly Ala 
65                  70                  75                  80  


Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Ala Thr Thr Gly 
                85                  90                  95      


Gly Thr Gly Cys Ala Gly Gly Cys Thr Gly Gly Gly Gly Gly Cys Thr 
            100                 105                 110         


Cys Thr Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly 
        115                 120                 125             


Thr Gly Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Gly Gly Thr 
    130                 135                 140                 


Ala Cys Ala Gly Gly Cys Ala Gly Gly Ala Gly Ala Thr Ala Thr Gly 
145                 150                 155                 160 


Cys Cys Ala Thr Gly Gly Gly Cys Thr Gly Gly Thr Thr Cys Cys Gly 
                165                 170                 175     


Cys Cys Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala Gly 
            180                 185                 190         


Gly Ala Gly Cys Gly Thr Gly Ala Ala Ala Thr Thr Gly Thr Ala Gly 
        195                 200                 205             


Cys Ala Gly Cys Gly Ala Thr Thr Ala Gly Gly Thr Gly Gly Ala Gly 
    210                 215                 220                 


Thr Gly Cys Thr Ala Thr Gly Ala Cys Ala Thr Ala Cys Thr Ala Thr 
225                 230                 235                 240 


Gly Cys Ala Gly Ala Cys Gly Ala Cys Gly Gly Gly Ala Ala Gly Gly 
                245                 250                 255     


Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys 
            260                 265                 270         


Cys Ala Gly Ala Gly Ala Cys Ala Ala Cys Gly Cys Cys Ala Ala Gly 
        275                 280                 285             


Ala Ala Cys Ala Cys Gly Gly Thr Gly Thr Ala Thr Cys Thr Cys Cys 
    290                 295                 300                 


Ala Ala Ala Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly Ala Ala 
305                 310                 315                 320 


Ala Cys Cys Thr Gly Ala Gly Gly Ala Cys Ala Cys Gly Gly Cys Cys 
                325                 330                 335     


Ala Thr Thr Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Ala Thr 
            340                 345                 350         


Ala Cys Ala Cys Thr Thr Gly Gly Gly Ala Cys Thr Ala Thr Thr Thr 
        355                 360                 365             


Cys Ala Ala Gly Thr Ala Thr Gly Ala Cys Cys Ala Ala Gly Thr Cys 
    370                 375                 380                 


Cys Gly Ala Gly Cys Gly Thr Ala Thr Cys Gly Cys Gly Gly Cys Thr 
385                 390                 395                 400 


Gly Gly Gly Gly Cys Cys Ala Gly Gly Gly Gly Ala Cys Cys Cys Thr 
                405                 410                 415     


Gly Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr Cys Cys Thr Cys Ala 
            420                 425                 430         


<210>  457
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding F0103478E09 (No tag)

<400>  457

Ala Thr Gly Ala Ala Ala Ala Ala Gly Ala Cys Cys Gly Cys Thr Ala 
1               5                   10                  15      


Thr Cys Gly Cys Gly Ala Thr Thr Gly Cys Ala Gly Thr Gly Gly Cys 
            20                  25                  30          


Ala Cys Thr Gly Gly Cys Thr Gly Gly Thr Thr Thr Gly Gly Cys Cys 
        35                  40                  45              


Ala Cys Cys Gly Thr Gly Gly Cys Cys Cys Ala Gly Gly Cys Cys Gly 
    50                  55                  60                  


Ala Gly Gly Thr Gly Cys Ala Ala Thr Thr Gly Gly Thr Gly Gly Ala 
65                  70                  75                  80  


Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Cys Thr Thr Gly 
                85                  90                  95      


Gly Thr Gly Cys Ala Gly Gly Cys Thr Gly Gly Gly Gly Gly Gly Thr 
            100                 105                 110         


Cys Thr Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly 
        115                 120                 125             


Thr Gly Cys Thr Gly Cys Cys Thr Cys Thr Gly Gly Ala Cys Gly Cys 
    130                 135                 140                 


Gly Cys Cys Thr Thr Cys Ala Gly Thr Ala Cys Cys Thr Thr Gly Gly 
145                 150                 155                 160 


Cys Cys Ala Thr Gly Gly Gly Cys Thr Gly Gly Thr Thr Cys Cys Gly 
                165                 170                 175     


Cys Cys Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala Gly 
            180                 185                 190         


Gly Ala Gly Cys Gly Thr Gly Ala Gly Thr Thr Thr Gly Thr Ala Gly 
        195                 200                 205             


Cys Ala Gly Cys Thr Ala Thr Thr Ala Gly Cys Cys Gly Gly Ala Ala 
    210                 215                 220                 


Thr Gly Gly Thr Ala Ala Thr Ala Ala Cys Thr Cys Ala Gly Cys Cys 
225                 230                 235                 240 


Ala Cys Thr Gly Gly Ala Gly Ala Cys Thr Cys Cys Cys Thr Gly Ala 
                245                 250                 255     


Ala Gly Gly Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr 
            260                 265                 270         


Cys Thr Cys Cys Ala Gly Ala Gly Ala Cys Ala Gly Cys Ala Cys Cys 
        275                 280                 285             


Ala Ala Gly Ala Gly Cys Ala Cys Gly Gly Thr Thr Thr Thr Thr Cys 
    290                 295                 300                 


Thr Gly Cys Ala Ala Ala Thr Gly Ala Ala Thr Ala Cys Gly Cys Thr 
305                 310                 315                 320 


Gly Ala Ala Ala Cys Cys Thr Gly Ala Gly Gly Ala Cys Ala Cys Gly 
                325                 330                 335     


Gly Cys Cys Gly Thr Ala Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly 
            340                 345                 350         


Cys Ala Gly Cys Cys Ala Thr Cys Thr Cys Gly Ala Cys Ala Cys Cys 
        355                 360                 365             


Gly Thr Cys Cys Gly Cys Cys Ala Gly Thr Cys Ala Thr Cys Cys Ala 
    370                 375                 380                 


Thr Ala Cys Gly Thr Thr Cys Gly Cys Ala Ala Gly Gly Ala Ala Ala 
385                 390                 395                 400 


Gly Thr Thr Ala Thr Ala Gly Ala Thr Ala Cys Thr Gly Gly Gly Gly 
                405                 410                 415     


Cys Cys Ala Gly Gly Gly Thr Ala Cys Cys Cys Thr Gly Gly Thr Cys 
            420                 425                 430         


Ala Cys Cys Gly Thr Cys Thr Cys Cys Thr Cys Ala 
        435                 440                 


<210>  458
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding F0103492E09 (No tag)

<400>  458

Ala Thr Gly Ala Ala Ala Ala Ala Gly Ala Cys Cys Gly Cys Thr Ala 
1               5                   10                  15      


Thr Cys Gly Cys Gly Ala Thr Thr Gly Cys Ala Gly Thr Gly Gly Cys 
            20                  25                  30          


Ala Cys Thr Gly Gly Cys Thr Gly Gly Thr Thr Thr Gly Gly Cys Cys 
        35                  40                  45              


Ala Cys Cys Gly Thr Gly Gly Cys Cys Cys Ala Gly Gly Cys Cys Gly 
    50                  55                  60                  


Ala Gly Gly Thr Gly Cys Ala Ala Thr Thr Gly Gly Thr Gly Gly Ala 
65                  70                  75                  80  


Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Cys Thr Thr Gly 
                85                  90                  95      


Gly Thr Gly Cys Ala Gly Gly Cys Thr Gly Gly Gly Gly Gly Ala Thr 
            100                 105                 110         


Cys Thr Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly 
        115                 120                 125             


Thr Gly Cys Ala Gly Cys Cys Thr Cys Thr Ala Ala Ala Ala Gly Cys 
    130                 135                 140                 


Ala Thr Cys Thr Thr Ala Ala Gly Thr Thr Thr Cys Gly Cys Thr Thr 
145                 150                 155                 160 


Ala Cys Ala Thr Gly Cys Gly Cys Thr Gly Gly Thr Ala Cys Cys Gly 
                165                 170                 175     


Cys Cys Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala Gly 
            180                 185                 190         


Cys Ala Gly Cys Gly Cys Gly Ala Gly Thr Thr Cys Gly Thr Cys Gly 
        195                 200                 205             


Cys Ala Ala Gly Thr Ala Thr Thr Gly Cys Thr Ala Thr Thr Gly Gly 
    210                 215                 220                 


Ala Gly Gly Thr Gly Cys Cys Ala Cys Ala Ala Gly Cys Thr Ala Thr 
225                 230                 235                 240 


Ala Cys Ala Gly Ala Cys Thr Cys Cys Gly Thr Gly Ala Ala Gly Gly 
                245                 250                 255     


Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys 
            260                 265                 270         


Cys Ala Gly Ala Gly Ala Cys Ala Ala Cys Gly Cys Cys Ala Ala Gly 
        275                 280                 285             


Ala Ala Cys Ala Cys Gly Gly Thr Gly Thr Ala Thr Cys Thr Gly Cys 
    290                 295                 300                 


Ala Ala Ala Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly Ala Ala 
305                 310                 315                 320 


Ala Cys Cys Thr Gly Ala Gly Gly Ala Cys Ala Cys Ala Gly Cys Cys 
                325                 330                 335     


Gly Thr Cys Thr Ala Thr Thr Ala Cys Thr Gly Thr Ala Gly Thr Gly 
            340                 345                 350         


Cys Ala Cys Cys Ala Gly Cys Cys Gly Gly Ala Cys Ala Gly Thr Ala 
        355                 360                 365             


Thr Cys Gly Gly Gly Gly Cys Cys Ala Gly Gly Gly Gly Ala Cys Cys 
    370                 375                 380                 


Cys Thr Gly Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr Cys Cys Thr 
385                 390                 395                 400 


Cys Ala 
        


<210>  459
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding F0103500E03 (No tag)

<400>  459

Ala Thr Gly Ala Ala Ala Ala Ala Gly Ala Cys Cys Gly Cys Thr Ala 
1               5                   10                  15      


Thr Cys Gly Cys Gly Ala Thr Thr Gly Cys Ala Gly Thr Gly Gly Cys 
            20                  25                  30          


Ala Cys Thr Gly Gly Cys Thr Gly Gly Thr Thr Thr Gly Gly Cys Cys 
        35                  40                  45              


Ala Cys Cys Gly Thr Gly Gly Cys Cys Cys Ala Gly Gly Cys Cys Gly 
    50                  55                  60                  


Ala Gly Gly Thr Gly Cys Ala Ala Thr Thr Gly Gly Thr Gly Gly Ala 
65                  70                  75                  80  


Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Ala Thr Thr Gly 
                85                  90                  95      


Gly Thr Gly Cys Ala Gly Cys Cys Gly Gly Gly Gly Gly Gly Cys Thr 
            100                 105                 110         


Cys Thr Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly 
        115                 120                 125             


Thr Gly Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Cys Gly Cys 
    130                 135                 140                 


Ala Cys Cys Thr Thr Cys Thr Cys Gly Cys Gly Cys Thr Ala Thr Cys 
145                 150                 155                 160 


Ala Gly Ala Thr Gly Gly Gly Cys Thr Gly Gly Thr Thr Cys Cys Gly 
                165                 170                 175     


Cys Cys Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala Gly 
            180                 185                 190         


Gly Ala Gly Cys Gly Thr Gly Ala Gly Thr Thr Thr Gly Thr Ala Gly 
        195                 200                 205             


Cys Ala Thr Ala Thr Ala Thr Thr Ala Gly Cys Thr Gly Gly Ala Gly 
    210                 215                 220                 


Thr Gly Gly Thr Ala Gly Thr Ala Cys Ala Cys Gly Thr Thr Ala Thr 
225                 230                 235                 240 


Gly Thr Thr Gly Ala Cys Thr Cys Cys Gly Thr Gly Ala Ala Gly Gly 
                245                 250                 255     


Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys 
            260                 265                 270         


Cys Ala Gly Ala Gly Ala Cys Ala Ala Cys Gly Cys Cys Ala Ala Gly 
        275                 280                 285             


Ala Ala Cys Ala Cys Gly Gly Thr Gly Thr Ala Thr Cys Thr Gly Cys 
    290                 295                 300                 


Ala Ala Ala Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly Ala Ala 
305                 310                 315                 320 


Ala Cys Cys Thr Gly Ala Gly Gly Ala Cys Ala Cys Gly Gly Cys Cys 
                325                 330                 335     


Gly Thr Thr Thr Ala Thr Cys Ala Cys Thr Gly Thr Gly Cys Ala Gly 
            340                 345                 350         


Cys Ala Gly Gly Gly Ala Cys Gly Gly Cys Cys Gly Gly Cys Ala Thr 
        355                 360                 365             


Ala Ala Thr Ala Thr Cys Thr Ala Gly Thr Ala Gly Gly Cys Cys Thr 
    370                 375                 380                 


Gly Ala Ala Ala Cys Thr Thr Ala Thr Gly Ala Cys Thr Cys Ala Thr 
385                 390                 395                 400 


Gly Gly Gly Gly Cys Cys Ala Gly Gly Gly Gly Ala Cys Cys Cys Thr 
                405                 410                 415     


Gly Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr Cys Cys Thr Cys Ala 
            420                 425                 430         


<210>  460
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding F0103505D08 (No tag)

<400>  460

Ala Thr Gly Ala Ala Ala Ala Ala Gly Ala Cys Cys Gly Cys Thr Ala 
1               5                   10                  15      


Thr Cys Gly Cys Gly Ala Thr Thr Gly Cys Ala Gly Thr Gly Gly Cys 
            20                  25                  30          


Ala Cys Thr Gly Gly Cys Thr Gly Gly Thr Thr Thr Gly Gly Cys Cys 
        35                  40                  45              


Ala Cys Cys Gly Thr Gly Gly Cys Cys Cys Ala Gly Gly Cys Cys Gly 
    50                  55                  60                  


Ala Gly Gly Thr Gly Cys Ala Ala Thr Thr Gly Gly Thr Gly Gly Ala 
65                  70                  75                  80  


Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Ala Thr Thr Gly 
                85                  90                  95      


Gly Thr Gly Cys Ala Gly Gly Cys Thr Gly Gly Gly Gly Gly Cys Thr 
            100                 105                 110         


Cys Thr Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly 
        115                 120                 125             


Thr Gly Thr Ala Ala Cys Cys Thr Cys Thr Gly Gly Ala Cys Gly Cys 
    130                 135                 140                 


Ala Cys Cys Thr Cys Cys Gly Ala Thr Thr Thr Gly Thr Cys Thr Ala 
145                 150                 155                 160 


Cys Cys Ala Thr Gly Ala Ala Cys Thr Gly Gly Thr Thr Cys Cys Gly 
                165                 170                 175     


Cys Cys Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Ala Ala Ala Gly 
            180                 185                 190         


Gly Ala Gly Cys Gly Thr Gly Ala Gly Thr Thr Thr Gly Thr Cys Gly 
        195                 200                 205             


Cys Ala Cys Gly Cys Ala Thr Cys Ala Cys Thr Cys Gly Gly Cys Gly 
    210                 215                 220                 


Thr Gly Gly Thr Ala Gly Cys Ala Cys Ala Thr Ala Cys Thr Ala Thr 
225                 230                 235                 240 


Gly Cys Ala Gly Ala Gly Thr Cys Cys Gly Thr Gly Ala Ala Gly Gly 
                245                 250                 255     


Ala Ala Cys Gly Ala Thr Thr Cys Ala Thr Cys Ala Thr Cys Thr Cys 
            260                 265                 270         


Cys Ala Gly Ala Gly Ala Cys Ala Ala Cys Gly Cys Cys Ala Ala Gly 
        275                 280                 285             


Ala Ala Cys Ala Cys Gly Gly Thr Gly Thr Ala Thr Thr Thr Gly Cys 
    290                 295                 300                 


Ala Ala Ala Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly Ala Ala 
305                 310                 315                 320 


Ala Cys Cys Ala Gly Ala Gly Gly Ala Cys Ala Cys Gly Gly Cys Cys 
                325                 330                 335     


Ala Ala Thr Thr Ala Thr Thr Ala Cys Thr Gly Thr Ala Cys Thr Gly 
            340                 345                 350         


Cys Ala Gly Cys Cys Thr Cys Ala Gly Ala Ala Ala Thr Gly Gly Gly 
        355                 360                 365             


Ala Thr Ala Thr Cys Ala Cys Thr Ala Cys Ala Gly Gly Gly Gly Cys 
    370                 375                 380                 


Cys Ala Gly Gly Gly Gly Ala Cys Cys Cys Thr Gly Gly Thr Cys Ala 
385                 390                 395                 400 


Cys Cys Gly Thr Cys Thr Cys Cys Thr Cys Ala 
                405                 410     


<210>  461
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding F0103495F09 (No tag)

<400>  461

Ala Thr Gly Ala Ala Ala Ala Ala Gly Ala Cys Cys Gly Cys Thr Ala 
1               5                   10                  15      


Thr Cys Gly Cys Gly Ala Thr Thr Gly Cys Ala Gly Thr Gly Gly Cys 
            20                  25                  30          


Ala Cys Thr Gly Gly Cys Thr Gly Gly Thr Thr Thr Gly Gly Cys Cys 
        35                  40                  45              


Ala Cys Cys Gly Thr Gly Gly Cys Cys Cys Ala Gly Gly Cys Cys Gly 
    50                  55                  60                  


Ala Gly Gly Thr Gly Cys Ala Ala Thr Thr Gly Gly Thr Gly Gly Ala 
65                  70                  75                  80  


Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Thr Thr Thr Gly 
                85                  90                  95      


Gly Thr Gly Cys Ala Gly Gly Cys Thr Gly Gly Ala Ala Gly Cys Thr 
            100                 105                 110         


Cys Thr Cys Thr Gly Ala Gly Thr Cys Thr Cys Thr Cys Cys Thr Gly 
        115                 120                 125             


Thr Gly Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Cys Gly Cys 
    130                 135                 140                 


Gly Cys Cys Thr Thr Gly Ala Gly Thr Ala Cys Ala Thr Ala Cys Gly 
145                 150                 155                 160 


Cys Cys Ala Thr Gly Gly Gly Cys Thr Gly Gly Thr Thr Cys Cys Gly 
                165                 170                 175     


Cys Cys Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala Gly 
            180                 185                 190         


Gly Ala Gly Cys Gly Thr Gly Ala Gly Thr Thr Thr Gly Thr Ala Gly 
        195                 200                 205             


Cys Ala Cys Gly Thr Ala Thr Thr Ala Gly Cys Cys Gly Gly Ala Gly 
    210                 215                 220                 


Cys Gly Gly Gly Ala Thr Thr Ala Cys Ala Ala Cys Ala Thr Ala Cys 
225                 230                 235                 240 


Thr Ala Thr Ala Cys Ala Gly Ala Cys Thr Cys Cys Gly Thr Gly Ala 
                245                 250                 255     


Ala Gly Gly Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr 
            260                 265                 270         


Cys Thr Cys Cys Ala Gly Ala Gly Ala Cys Cys Gly Cys Gly Cys Cys 
        275                 280                 285             


Ala Ala Gly Gly Ala Cys Ala Cys Gly Gly Thr Gly Thr Ala Thr Cys 
    290                 295                 300                 


Thr Gly Cys Ala Ala Ala Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr 
305                 310                 315                 320 


Gly Ala Ala Ala Cys Cys Thr Gly Ala Gly Gly Ala Cys Ala Cys Gly 
                325                 330                 335     


Gly Cys Cys Ala Thr Thr Thr Ala Thr Thr Thr Gly Thr Gly Thr Gly 
            340                 345                 350         


Cys Ala Gly Cys Ala Gly Ala Cys Gly Cys Cys Thr Cys Ala Ala Cys 
        355                 360                 365             


Cys Ala Ala Thr Cys Cys Thr Gly Cys Thr Gly Gly Ala Thr Ala Cys 
    370                 375                 380                 


Thr Ala Cys Cys Thr Thr Cys Gly Gly Ala Ala Thr Cys Gly Thr Thr 
385                 390                 395                 400 


Ala Thr Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly Cys Cys Ala 
                405                 410                 415     


Gly Gly Gly Gly Ala Cys Cys Cys Thr Gly Gly Thr Cys Ala Cys Cys 
            420                 425                 430         


Gly Thr Cys Thr Cys Cys Thr Cys Ala 
        435                 440     


<210>  462
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50GS linker

<400>  462

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210>  463
<211>  1146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding F010302375 (No tag)

<400>  463

Ala Thr Gly Ala Gly Ala Thr Thr Thr Cys Cys Thr Thr Cys Ala Ala 
1               5                   10                  15      


Thr Thr Thr Thr Thr Ala Cys Thr Gly Cys Thr Gly Thr Thr Thr Thr 
            20                  25                  30          


Ala Thr Thr Cys Gly Cys Ala Gly Cys Ala Thr Cys Cys Thr Cys Cys 
        35                  40                  45              


Gly Cys Ala Thr Thr Ala Gly Cys Thr Gly Cys Thr Cys Cys Ala Gly 
    50                  55                  60                  


Thr Cys Ala Ala Cys Ala Cys Thr Ala Cys Ala Ala Cys Ala Gly Ala 
65                  70                  75                  80  


Ala Gly Ala Thr Gly Ala Ala Ala Cys Gly Gly Cys Ala Cys Ala Ala 
                85                  90                  95      


Ala Thr Thr Cys Cys Gly Gly Cys Thr Gly Ala Ala Gly Cys Thr Gly 
            100                 105                 110         


Thr Cys Ala Thr Cys Gly Gly Thr Thr Ala Cys Thr Cys Ala Gly Ala 
        115                 120                 125             


Thr Thr Thr Ala Gly Ala Ala Gly Gly Gly Gly Ala Thr Thr Thr Cys 
    130                 135                 140                 


Gly Ala Thr Gly Thr Thr Gly Cys Thr Gly Thr Thr Thr Thr Gly Cys 
145                 150                 155                 160 


Cys Ala Thr Thr Thr Thr Cys Cys Ala Ala Cys Ala Gly Cys Ala Cys 
                165                 170                 175     


Ala Ala Ala Thr Ala Ala Cys Gly Gly Gly Thr Thr Ala Thr Thr Gly 
            180                 185                 190         


Thr Thr Thr Ala Thr Ala Ala Ala Thr Ala Cys Thr Ala Cys Thr Ala 
        195                 200                 205             


Thr Thr Gly Cys Cys Ala Gly Cys Ala Thr Thr Gly Cys Thr Gly Cys 
    210                 215                 220                 


Thr Ala Ala Ala Gly Ala Ala Gly Ala Ala Gly Gly Gly Gly Thr Ala 
225                 230                 235                 240 


Thr Cys Thr Cys Thr Cys Gly Ala Ala Ala Ala Gly Ala Gly Ala Gly 
                245                 250                 255     


Ala Cys Gly Thr Gly Cys Ala Ala Thr Thr Gly Gly Thr Gly Gly Ala 
            260                 265                 270         


Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Cys Thr Thr Gly 
        275                 280                 285             


Gly Thr Gly Cys Ala Gly Cys Cys Thr Gly Gly Gly Gly Gly Gly Thr 
    290                 295                 300                 


Cys Thr Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly 
305                 310                 315                 320 


Thr Gly Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Ala Gly Cys 
                325                 330                 335     


Ala Thr Cys Thr Thr Cys Ala Ala Thr Ala Thr Cys Ala Ala Cys Ala 
            340                 345                 350         


Gly Thr Ala Thr Gly Gly Cys Cys Thr Gly Gly Thr Ala Thr Cys Gly 
        355                 360                 365             


Cys Cys Gly Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala Gly 
    370                 375                 380                 


Cys Ala Gly Cys Gly Cys Gly Ala Ala Thr Thr Gly Gly Thr Cys Gly 
385                 390                 395                 400 


Cys Ala Ala Gly Thr Ala Gly Cys Ala Cys Cys Ala Ala Thr Gly Gly 
                405                 410                 415     


Thr Gly Gly Thr Ala Gly Thr Ala Cys Ala Ala Ala Cys Thr Ala Thr 
            420                 425                 430         


Gly Cys Ala Gly Ala Cys Thr Cys Cys Gly Thr Gly Ala Ala Gly Gly 
        435                 440                 445             


Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys 
    450                 455                 460                 


Thr Ala Gly Ala Gly Ala Cys Ala Ala Cys Gly Cys Cys Ala Ala Ala 
465                 470                 475                 480 


Cys Gly Gly Gly Thr Gly Thr Ala Thr Cys Thr Gly Cys Ala Ala Ala 
                485                 490                 495     


Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly Ala Cys Ala Cys Cys 
            500                 505                 510         


Thr Gly Ala Gly Gly Ala Cys Ala Cys Gly Gly Cys Cys Gly Thr Cys 
        515                 520                 525             


Thr Ala Thr Thr Ala Thr Thr Gly Thr Cys Gly Thr Gly Cys Ala Cys 
    530                 535                 540                 


Thr Gly Cys Thr Ala Cys Ala Ala Cys Cys Gly Thr Cys Gly Ala Thr 
545                 550                 555                 560 


Thr Thr Ala Thr Gly Ala Cys Ala Thr Thr Ala Gly Thr Cys Gly Cys 
                565                 570                 575     


Ala Cys Ala Thr Ala Thr Thr Gly Gly Gly Gly Cys Cys Ala Gly Gly 
            580                 585                 590         


Gly Gly Ala Cys Cys Cys Thr Gly Gly Thr Cys Ala Cys Gly Gly Thr 
        595                 600                 605             


Cys Thr Cys Cys Thr Cys Cys Gly Gly Ala Gly Gly Thr Gly Gly Thr 
    610                 615                 620                 


Gly Gly Cys Ala Gly Cys Gly Gly Thr Gly Gly Ala Gly Gly Thr Gly 
625                 630                 635                 640 


Gly Thr Thr Cys Thr Gly Gly Gly Gly Gly Thr Gly Gly Cys Gly Gly 
                645                 650                 655     


Thr Ala Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Cys 
            660                 665                 670         


Thr Cys Ala Gly Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Gly Thr 
        675                 680                 685             


Cys Ala Gly Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Cys Ala Gly 
    690                 695                 700                 


Thr Gly Gly Thr Gly Gly Gly Gly Gly Thr Gly Gly Cys Ala Gly Cys 
705                 710                 715                 720 


Gly Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Ala Thr Cys Thr Gly 
                725                 730                 735     


Gly Thr Gly Gly Ala Gly Gly Thr Gly Gly Thr Thr Cys Thr Gly Gly 
            740                 745                 750         


Ala Gly Gly Thr Gly Gly Ala Gly Gly Ala Thr Cys Cys Gly Ala Gly 
        755                 760                 765             


Gly Thr Gly Cys Ala Gly Thr Thr Gly Gly Thr Gly Gly Ala Gly Thr 
    770                 775                 780                 


Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Cys Thr Thr Gly Gly Thr 
785                 790                 795                 800 


Gly Cys Ala Gly Gly Cys Thr Gly Gly Gly Gly Gly Gly Thr Cys Thr 
                805                 810                 815     


Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly Thr Gly 
            820                 825                 830         


Cys Thr Gly Cys Cys Thr Cys Thr Gly Gly Ala Cys Gly Cys Gly Cys 
        835                 840                 845             


Cys Thr Thr Cys Ala Gly Thr Ala Cys Cys Thr Thr Gly Gly Cys Cys 
    850                 855                 860                 


Ala Thr Gly Gly Gly Cys Thr Gly Gly Thr Thr Cys Cys Gly Cys Cys 
865                 870                 875                 880 


Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala Gly Gly Ala 
                885                 890                 895     


Gly Cys Gly Thr Gly Ala Gly Thr Thr Thr Gly Thr Ala Gly Cys Ala 
            900                 905                 910         


Gly Cys Thr Ala Thr Thr Ala Gly Cys Cys Gly Gly Ala Ala Thr Gly 
        915                 920                 925             


Gly Thr Ala Ala Thr Ala Ala Cys Thr Cys Ala Gly Cys Cys Ala Cys 
    930                 935                 940                 


Thr Gly Gly Ala Gly Ala Cys Thr Cys Cys Cys Thr Gly Ala Ala Gly 
945                 950                 955                 960 


Gly Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr 
                965                 970                 975     


Cys Cys Ala Gly Ala Gly Ala Cys Ala Gly Cys Ala Cys Cys Ala Ala 
            980                 985                 990         


Gly Ala Gly Cys Ala Cys Gly Gly  Thr Thr Thr Thr Thr  Cys Thr Gly 
        995                 1000                 1005             


Cys Ala  Ala Ala Thr Gly Ala  Ala Thr Ala Cys Gly  Cys Thr Gly 
    1010                 1015                 1020             


Ala Ala  Ala Cys Cys Thr Gly  Ala Gly Gly Ala Cys  Ala Cys Gly 
    1025                 1030                 1035             


Gly Cys  Cys Gly Thr Ala Thr  Ala Thr Thr Ala Cys  Thr Gly Thr 
    1040                 1045                 1050             


Gly Cys  Ala Gly Cys Cys Ala  Thr Cys Thr Cys Gly  Ala Cys Ala 
    1055                 1060                 1065             


Cys Cys  Gly Thr Cys Cys Gly  Cys Cys Ala Gly Thr  Cys Ala Thr 
    1070                 1075                 1080             


Cys Cys  Ala Thr Ala Cys Gly  Thr Thr Cys Gly Cys  Ala Ala Gly 
    1085                 1090                 1095             


Gly Ala  Ala Ala Gly Thr Thr  Ala Thr Ala Gly Ala  Thr Ala Cys 
    1100                 1105                 1110             


Thr Gly  Gly Gly Gly Cys Cys  Ala Gly Gly Gly Thr  Ala Cys Cys 
    1115                 1120                 1125             


Cys Ala  Gly Gly Thr Cys Ala  Cys Cys Gly Thr Cys  Thr Cys Cys 
    1130                 1135                 1140             


Thr Cys  Ala 
    1145     


<210>  464
<211>  1104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding F010302377 (No tag)

<400>  464

Ala Thr Gly Ala Gly Ala Thr Thr Thr Cys Cys Thr Thr Cys Ala Ala 
1               5                   10                  15      


Thr Thr Thr Thr Thr Ala Cys Thr Gly Cys Thr Gly Thr Thr Thr Thr 
            20                  25                  30          


Ala Thr Thr Cys Gly Cys Ala Gly Cys Ala Thr Cys Cys Thr Cys Cys 
        35                  40                  45              


Gly Cys Ala Thr Thr Ala Gly Cys Thr Gly Cys Thr Cys Cys Ala Gly 
    50                  55                  60                  


Thr Cys Ala Ala Cys Ala Cys Thr Ala Cys Ala Ala Cys Ala Gly Ala 
65                  70                  75                  80  


Ala Gly Ala Thr Gly Ala Ala Ala Cys Gly Gly Cys Ala Cys Ala Ala 
                85                  90                  95      


Ala Thr Thr Cys Cys Gly Gly Cys Thr Gly Ala Ala Gly Cys Thr Gly 
            100                 105                 110         


Thr Cys Ala Thr Cys Gly Gly Thr Thr Ala Cys Thr Cys Ala Gly Ala 
        115                 120                 125             


Thr Thr Thr Ala Gly Ala Ala Gly Gly Gly Gly Ala Thr Thr Thr Cys 
    130                 135                 140                 


Gly Ala Thr Gly Thr Thr Gly Cys Thr Gly Thr Thr Thr Thr Gly Cys 
145                 150                 155                 160 


Cys Ala Thr Thr Thr Thr Cys Cys Ala Ala Cys Ala Gly Cys Ala Cys 
                165                 170                 175     


Ala Ala Ala Thr Ala Ala Cys Gly Gly Gly Thr Thr Ala Thr Thr Gly 
            180                 185                 190         


Thr Thr Thr Ala Thr Ala Ala Ala Thr Ala Cys Thr Ala Cys Thr Ala 
        195                 200                 205             


Thr Thr Gly Cys Cys Ala Gly Cys Ala Thr Thr Gly Cys Thr Gly Cys 
    210                 215                 220                 


Thr Ala Ala Ala Gly Ala Ala Gly Ala Ala Gly Gly Gly Gly Thr Ala 
225                 230                 235                 240 


Thr Cys Thr Cys Thr Cys Gly Ala Ala Ala Ala Gly Ala Gly Ala Gly 
                245                 250                 255     


Ala Cys Gly Thr Gly Cys Ala Ala Thr Thr Gly Gly Thr Gly Gly Ala 
            260                 265                 270         


Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Cys Thr Thr Gly 
        275                 280                 285             


Gly Thr Gly Cys Ala Gly Cys Cys Thr Gly Gly Gly Gly Gly Gly Thr 
    290                 295                 300                 


Cys Thr Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly 
305                 310                 315                 320 


Thr Gly Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Ala Gly Cys 
                325                 330                 335     


Ala Thr Cys Thr Thr Cys Ala Ala Thr Ala Thr Cys Ala Ala Cys Ala 
            340                 345                 350         


Gly Thr Ala Thr Gly Gly Cys Cys Thr Gly Gly Thr Ala Thr Cys Gly 
        355                 360                 365             


Cys Cys Gly Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala Gly 
    370                 375                 380                 


Cys Ala Gly Cys Gly Cys Gly Ala Ala Thr Thr Gly Gly Thr Cys Gly 
385                 390                 395                 400 


Cys Ala Ala Gly Thr Ala Gly Cys Ala Cys Cys Ala Ala Thr Gly Gly 
                405                 410                 415     


Thr Gly Gly Thr Ala Gly Thr Ala Cys Ala Ala Ala Cys Thr Ala Thr 
            420                 425                 430         


Gly Cys Ala Gly Ala Cys Thr Cys Cys Gly Thr Gly Ala Ala Gly Gly 
        435                 440                 445             


Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys 
    450                 455                 460                 


Thr Ala Gly Ala Gly Ala Cys Ala Ala Cys Gly Cys Cys Ala Ala Ala 
465                 470                 475                 480 


Cys Gly Gly Gly Thr Gly Thr Ala Thr Cys Thr Gly Cys Ala Ala Ala 
                485                 490                 495     


Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly Ala Cys Ala Cys Cys 
            500                 505                 510         


Thr Gly Ala Gly Gly Ala Cys Ala Cys Gly Gly Cys Cys Gly Thr Cys 
        515                 520                 525             


Thr Ala Thr Thr Ala Thr Thr Gly Thr Cys Gly Thr Gly Cys Ala Cys 
    530                 535                 540                 


Thr Gly Cys Thr Ala Cys Ala Ala Cys Cys Gly Thr Cys Gly Ala Thr 
545                 550                 555                 560 


Thr Thr Ala Thr Gly Ala Cys Ala Thr Thr Ala Gly Thr Cys Gly Cys 
                565                 570                 575     


Ala Cys Ala Thr Ala Thr Thr Gly Gly Gly Gly Cys Cys Ala Gly Gly 
            580                 585                 590         


Gly Gly Ala Cys Cys Cys Thr Gly Gly Thr Cys Ala Cys Gly Gly Thr 
        595                 600                 605             


Cys Thr Cys Cys Thr Cys Cys Gly Gly Ala Gly Gly Thr Gly Gly Thr 
    610                 615                 620                 


Gly Gly Cys Ala Gly Cys Gly Gly Thr Gly Gly Ala Gly Gly Thr Gly 
625                 630                 635                 640 


Gly Thr Thr Cys Thr Gly Gly Gly Gly Gly Thr Gly Gly Cys Gly Gly 
                645                 650                 655     


Thr Ala Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Cys 
            660                 665                 670         


Thr Cys Ala Gly Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Gly Thr 
        675                 680                 685             


Cys Ala Gly Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Cys Ala Gly 
    690                 695                 700                 


Thr Gly Gly Thr Gly Gly Gly Gly Gly Thr Gly Gly Cys Ala Gly Cys 
705                 710                 715                 720 


Gly Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Ala Thr Cys Thr Gly 
                725                 730                 735     


Gly Thr Gly Gly Ala Gly Gly Thr Gly Gly Thr Thr Cys Thr Gly Gly 
            740                 745                 750         


Ala Gly Gly Thr Gly Gly Ala Gly Gly Ala Thr Cys Cys Gly Ala Gly 
        755                 760                 765             


Gly Thr Gly Cys Ala Gly Thr Thr Gly Gly Thr Gly Gly Ala Gly Thr 
    770                 775                 780                 


Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Cys Thr Thr Gly Gly Thr 
785                 790                 795                 800 


Gly Cys Ala Gly Gly Cys Thr Gly Gly Gly Gly Gly Ala Thr Cys Thr 
                805                 810                 815     


Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly Thr Gly 
            820                 825                 830         


Cys Ala Gly Cys Cys Thr Cys Thr Ala Ala Ala Ala Gly Cys Ala Thr 
        835                 840                 845             


Cys Thr Thr Ala Ala Gly Thr Thr Thr Cys Gly Cys Thr Thr Ala Cys 
    850                 855                 860                 


Ala Thr Gly Cys Gly Cys Thr Gly Gly Thr Ala Cys Cys Gly Cys Cys 
865                 870                 875                 880 


Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala Gly Cys Ala 
                885                 890                 895     


Gly Cys Gly Cys Gly Ala Gly Thr Thr Cys Gly Thr Cys Gly Cys Ala 
            900                 905                 910         


Ala Gly Thr Ala Thr Thr Gly Cys Thr Ala Thr Thr Gly Gly Ala Gly 
        915                 920                 925             


Gly Thr Gly Cys Cys Ala Cys Ala Ala Gly Cys Thr Ala Thr Ala Cys 
    930                 935                 940                 


Ala Gly Ala Cys Thr Cys Cys Gly Thr Gly Ala Ala Gly Gly Gly Cys 
945                 950                 955                 960 


Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys Cys Ala 
                965                 970                 975     


Gly Ala Gly Ala Cys Ala Ala Cys Gly Cys Cys Ala Ala Gly Ala Ala 
            980                 985                 990         


Cys Ala Cys Gly Gly Thr Gly Thr  Ala Thr Cys Thr Gly  Cys Ala Ala 
        995                 1000                 1005             


Ala Thr  Gly Ala Ala Cys Ala  Gly Cys Cys Thr Gly  Ala Ala Ala 
    1010                 1015                 1020             


Cys Cys  Thr Gly Ala Gly Gly  Ala Cys Ala Cys Ala  Gly Cys Cys 
    1025                 1030                 1035             


Gly Thr  Cys Thr Ala Thr Thr  Ala Cys Thr Gly Thr  Ala Gly Thr 
    1040                 1045                 1050             


Gly Cys  Ala Cys Cys Ala Gly  Cys Cys Gly Gly Ala  Cys Ala Gly 
    1055                 1060                 1065             


Thr Ala  Thr Cys Gly Gly Gly  Gly Cys Cys Ala Gly  Gly Gly Gly 
    1070                 1075                 1080             


Ala Cys  Cys Cys Thr Gly Gly  Thr Cys Ala Cys Cys  Gly Thr Cys 
    1085                 1090                 1095             


Thr Cys  Cys Thr Cys Ala 
    1100                 


<210>  465
<211>  1143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding F010302378 (No tag)

<400>  465

Ala Thr Gly Ala Gly Ala Thr Thr Thr Cys Cys Thr Thr Cys Ala Ala 
1               5                   10                  15      


Thr Thr Thr Thr Thr Ala Cys Thr Gly Cys Thr Gly Thr Thr Thr Thr 
            20                  25                  30          


Ala Thr Thr Cys Gly Cys Ala Gly Cys Ala Thr Cys Cys Thr Cys Cys 
        35                  40                  45              


Gly Cys Ala Thr Thr Ala Gly Cys Thr Gly Cys Thr Cys Cys Ala Gly 
    50                  55                  60                  


Thr Cys Ala Ala Cys Ala Cys Thr Ala Cys Ala Ala Cys Ala Gly Ala 
65                  70                  75                  80  


Ala Gly Ala Thr Gly Ala Ala Ala Cys Gly Gly Cys Ala Cys Ala Ala 
                85                  90                  95      


Ala Thr Thr Cys Cys Gly Gly Cys Thr Gly Ala Ala Gly Cys Thr Gly 
            100                 105                 110         


Thr Cys Ala Thr Cys Gly Gly Thr Thr Ala Cys Thr Cys Ala Gly Ala 
        115                 120                 125             


Thr Thr Thr Ala Gly Ala Ala Gly Gly Gly Gly Ala Thr Thr Thr Cys 
    130                 135                 140                 


Gly Ala Thr Gly Thr Thr Gly Cys Thr Gly Thr Thr Thr Thr Gly Cys 
145                 150                 155                 160 


Cys Ala Thr Thr Thr Thr Cys Cys Ala Ala Cys Ala Gly Cys Ala Cys 
                165                 170                 175     


Ala Ala Ala Thr Ala Ala Cys Gly Gly Gly Thr Thr Ala Thr Thr Gly 
            180                 185                 190         


Thr Thr Thr Ala Thr Ala Ala Ala Thr Ala Cys Thr Ala Cys Thr Ala 
        195                 200                 205             


Thr Thr Gly Cys Cys Ala Gly Cys Ala Thr Thr Gly Cys Thr Gly Cys 
    210                 215                 220                 


Thr Ala Ala Ala Gly Ala Ala Gly Ala Ala Gly Gly Gly Gly Thr Ala 
225                 230                 235                 240 


Thr Cys Thr Cys Thr Cys Gly Ala Ala Ala Ala Gly Ala Gly Ala Gly 
                245                 250                 255     


Ala Cys Gly Thr Gly Cys Ala Ala Thr Thr Gly Gly Thr Gly Gly Ala 
            260                 265                 270         


Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Cys Thr Thr Gly 
        275                 280                 285             


Gly Thr Gly Cys Ala Gly Cys Cys Thr Gly Gly Gly Gly Gly Gly Thr 
    290                 295                 300                 


Cys Thr Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly 
305                 310                 315                 320 


Thr Gly Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Ala Gly Cys 
                325                 330                 335     


Ala Thr Cys Thr Thr Cys Ala Ala Thr Ala Thr Cys Ala Ala Cys Ala 
            340                 345                 350         


Gly Thr Ala Thr Gly Gly Cys Cys Thr Gly Gly Thr Ala Thr Cys Gly 
        355                 360                 365             


Cys Cys Gly Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala Gly 
    370                 375                 380                 


Cys Ala Gly Cys Gly Cys Gly Ala Ala Thr Thr Gly Gly Thr Cys Gly 
385                 390                 395                 400 


Cys Ala Ala Gly Thr Ala Gly Cys Ala Cys Cys Ala Ala Thr Gly Gly 
                405                 410                 415     


Thr Gly Gly Thr Ala Gly Thr Ala Cys Ala Ala Ala Cys Thr Ala Thr 
            420                 425                 430         


Gly Cys Ala Gly Ala Cys Thr Cys Cys Gly Thr Gly Ala Ala Gly Gly 
        435                 440                 445             


Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys 
    450                 455                 460                 


Thr Ala Gly Ala Gly Ala Cys Ala Ala Cys Gly Cys Cys Ala Ala Ala 
465                 470                 475                 480 


Cys Gly Gly Gly Thr Gly Thr Ala Thr Cys Thr Gly Cys Ala Ala Ala 
                485                 490                 495     


Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly Ala Cys Ala Cys Cys 
            500                 505                 510         


Thr Gly Ala Gly Gly Ala Cys Ala Cys Gly Gly Cys Cys Gly Thr Cys 
        515                 520                 525             


Thr Ala Thr Thr Ala Thr Thr Gly Thr Cys Gly Thr Gly Cys Ala Cys 
    530                 535                 540                 


Thr Gly Cys Thr Ala Cys Ala Ala Cys Cys Gly Thr Cys Gly Ala Thr 
545                 550                 555                 560 


Thr Thr Ala Thr Gly Ala Cys Ala Thr Thr Ala Gly Thr Cys Gly Cys 
                565                 570                 575     


Ala Cys Ala Thr Ala Thr Thr Gly Gly Gly Gly Cys Cys Ala Gly Gly 
            580                 585                 590         


Gly Gly Ala Cys Cys Cys Thr Gly Gly Thr Cys Ala Cys Gly Gly Thr 
        595                 600                 605             


Cys Thr Cys Cys Thr Cys Cys Gly Gly Ala Gly Gly Thr Gly Gly Thr 
    610                 615                 620                 


Gly Gly Cys Ala Gly Cys Gly Gly Thr Gly Gly Ala Gly Gly Thr Gly 
625                 630                 635                 640 


Gly Thr Thr Cys Thr Gly Gly Gly Gly Gly Thr Gly Gly Cys Gly Gly 
                645                 650                 655     


Thr Ala Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Cys 
            660                 665                 670         


Thr Cys Ala Gly Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Gly Thr 
        675                 680                 685             


Cys Ala Gly Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Cys Ala Gly 
    690                 695                 700                 


Thr Gly Gly Thr Gly Gly Gly Gly Gly Thr Gly Gly Cys Ala Gly Cys 
705                 710                 715                 720 


Gly Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Ala Thr Cys Thr Gly 
                725                 730                 735     


Gly Thr Gly Gly Ala Gly Gly Thr Gly Gly Thr Thr Cys Thr Gly Gly 
            740                 745                 750         


Ala Gly Gly Thr Gly Gly Ala Gly Gly Ala Thr Cys Cys Gly Ala Gly 
        755                 760                 765             


Gly Thr Gly Cys Ala Gly Thr Thr Gly Gly Thr Gly Gly Ala Gly Thr 
    770                 775                 780                 


Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Thr Thr Thr Gly Gly Thr 
785                 790                 795                 800 


Gly Cys Ala Gly Gly Cys Thr Gly Gly Ala Ala Gly Cys Thr Cys Thr 
                805                 810                 815     


Cys Thr Gly Ala Gly Thr Cys Thr Cys Thr Cys Cys Thr Gly Thr Gly 
            820                 825                 830         


Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Cys Gly Cys Gly Cys 
        835                 840                 845             


Cys Thr Thr Gly Ala Gly Thr Ala Cys Ala Thr Ala Cys Gly Cys Cys 
    850                 855                 860                 


Ala Thr Gly Gly Gly Cys Thr Gly Gly Thr Thr Cys Cys Gly Cys Cys 
865                 870                 875                 880 


Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala Gly Gly Ala 
                885                 890                 895     


Gly Cys Gly Thr Gly Ala Gly Thr Thr Thr Gly Thr Ala Gly Cys Ala 
            900                 905                 910         


Cys Gly Thr Ala Thr Thr Ala Gly Cys Cys Gly Gly Ala Gly Cys Gly 
        915                 920                 925             


Gly Gly Ala Thr Thr Ala Cys Ala Ala Cys Ala Thr Ala Cys Thr Ala 
    930                 935                 940                 


Thr Ala Cys Ala Gly Ala Cys Thr Cys Cys Gly Thr Gly Ala Ala Gly 
945                 950                 955                 960 


Gly Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr 
                965                 970                 975     


Cys Cys Ala Gly Ala Gly Ala Cys Cys Gly Cys Gly Cys Cys Ala Ala 
            980                 985                 990         


Gly Gly Ala Cys Ala Cys Gly Gly  Thr Gly Thr Ala Thr  Cys Thr Gly 
        995                 1000                 1005             


Cys Ala  Ala Ala Thr Gly Ala  Ala Cys Ala Gly Cys  Cys Thr Gly 
    1010                 1015                 1020             


Ala Ala  Ala Cys Cys Thr Gly  Ala Gly Gly Ala Cys  Ala Cys Gly 
    1025                 1030                 1035             


Gly Cys  Cys Ala Thr Thr Thr  Ala Thr Thr Thr Gly  Thr Gly Thr 
    1040                 1045                 1050             


Gly Cys  Ala Gly Cys Ala Gly  Ala Cys Gly Cys Cys  Thr Cys Ala 
    1055                 1060                 1065             


Ala Cys  Cys Ala Ala Thr Cys  Cys Thr Gly Cys Thr  Gly Gly Ala 
    1070                 1075                 1080             


Thr Ala  Cys Thr Ala Cys Cys  Thr Thr Cys Gly Gly  Ala Ala Thr 
    1085                 1090                 1095             


Cys Gly  Thr Thr Ala Thr Gly  Ala Cys Thr Ala Cys  Thr Gly Gly 
    1100                 1105                 1110             


Gly Gly  Cys Cys Ala Gly Gly  Gly Gly Ala Cys Cys  Cys Thr Gly 
    1115                 1120                 1125             


Gly Thr  Cys Ala Cys Cys Gly  Thr Cys Thr Cys Cys  Thr Cys Ala 
    1130                 1135                 1140             


<210>  466
<211>  1134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding F010302379 (No tag)

<400>  466

Ala Thr Gly Ala Gly Ala Thr Thr Thr Cys Cys Thr Thr Cys Ala Ala 
1               5                   10                  15      


Thr Thr Thr Thr Thr Ala Cys Thr Gly Cys Thr Gly Thr Thr Thr Thr 
            20                  25                  30          


Ala Thr Thr Cys Gly Cys Ala Gly Cys Ala Thr Cys Cys Thr Cys Cys 
        35                  40                  45              


Gly Cys Ala Thr Thr Ala Gly Cys Thr Gly Cys Thr Cys Cys Ala Gly 
    50                  55                  60                  


Thr Cys Ala Ala Cys Ala Cys Thr Ala Cys Ala Ala Cys Ala Gly Ala 
65                  70                  75                  80  


Ala Gly Ala Thr Gly Ala Ala Ala Cys Gly Gly Cys Ala Cys Ala Ala 
                85                  90                  95      


Ala Thr Thr Cys Cys Gly Gly Cys Thr Gly Ala Ala Gly Cys Thr Gly 
            100                 105                 110         


Thr Cys Ala Thr Cys Gly Gly Thr Thr Ala Cys Thr Cys Ala Gly Ala 
        115                 120                 125             


Thr Thr Thr Ala Gly Ala Ala Gly Gly Gly Gly Ala Thr Thr Thr Cys 
    130                 135                 140                 


Gly Ala Thr Gly Thr Thr Gly Cys Thr Gly Thr Thr Thr Thr Gly Cys 
145                 150                 155                 160 


Cys Ala Thr Thr Thr Thr Cys Cys Ala Ala Cys Ala Gly Cys Ala Cys 
                165                 170                 175     


Ala Ala Ala Thr Ala Ala Cys Gly Gly Gly Thr Thr Ala Thr Thr Gly 
            180                 185                 190         


Thr Thr Thr Ala Thr Ala Ala Ala Thr Ala Cys Thr Ala Cys Thr Ala 
        195                 200                 205             


Thr Thr Gly Cys Cys Ala Gly Cys Ala Thr Thr Gly Cys Thr Gly Cys 
    210                 215                 220                 


Thr Ala Ala Ala Gly Ala Ala Gly Ala Ala Gly Gly Gly Gly Thr Ala 
225                 230                 235                 240 


Thr Cys Thr Cys Thr Cys Gly Ala Ala Ala Ala Gly Ala Gly Ala Gly 
                245                 250                 255     


Ala Cys Gly Thr Gly Cys Ala Ala Thr Thr Gly Gly Thr Gly Gly Ala 
            260                 265                 270         


Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Cys Thr Thr Gly 
        275                 280                 285             


Gly Thr Gly Cys Ala Gly Cys Cys Thr Gly Gly Gly Gly Gly Gly Thr 
    290                 295                 300                 


Cys Thr Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly 
305                 310                 315                 320 


Thr Gly Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Ala Gly Cys 
                325                 330                 335     


Ala Thr Cys Thr Thr Cys Ala Ala Thr Ala Thr Cys Ala Ala Cys Ala 
            340                 345                 350         


Gly Thr Ala Thr Gly Gly Cys Cys Thr Gly Gly Thr Ala Thr Cys Gly 
        355                 360                 365             


Cys Cys Gly Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala Gly 
    370                 375                 380                 


Cys Ala Gly Cys Gly Cys Gly Ala Ala Thr Thr Gly Gly Thr Cys Gly 
385                 390                 395                 400 


Cys Ala Ala Gly Thr Ala Gly Cys Ala Cys Cys Ala Ala Thr Gly Gly 
                405                 410                 415     


Thr Gly Gly Thr Ala Gly Thr Ala Cys Ala Ala Ala Cys Thr Ala Thr 
            420                 425                 430         


Gly Cys Ala Gly Ala Cys Thr Cys Cys Gly Thr Gly Ala Ala Gly Gly 
        435                 440                 445             


Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys 
    450                 455                 460                 


Thr Ala Gly Ala Gly Ala Cys Ala Ala Cys Gly Cys Cys Ala Ala Ala 
465                 470                 475                 480 


Cys Gly Gly Gly Thr Gly Thr Ala Thr Cys Thr Gly Cys Ala Ala Ala 
                485                 490                 495     


Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly Ala Cys Ala Cys Cys 
            500                 505                 510         


Thr Gly Ala Gly Gly Ala Cys Ala Cys Gly Gly Cys Cys Gly Thr Cys 
        515                 520                 525             


Thr Ala Thr Thr Ala Thr Thr Gly Thr Cys Gly Thr Gly Cys Ala Cys 
    530                 535                 540                 


Thr Gly Cys Thr Ala Cys Ala Ala Cys Cys Gly Thr Cys Gly Ala Thr 
545                 550                 555                 560 


Thr Thr Ala Thr Gly Ala Cys Ala Thr Thr Ala Gly Thr Cys Gly Cys 
                565                 570                 575     


Ala Cys Ala Thr Ala Thr Thr Gly Gly Gly Gly Cys Cys Ala Gly Gly 
            580                 585                 590         


Gly Gly Ala Cys Cys Cys Thr Gly Gly Thr Cys Ala Cys Gly Gly Thr 
        595                 600                 605             


Cys Thr Cys Cys Thr Cys Cys Gly Gly Ala Gly Gly Thr Gly Gly Thr 
    610                 615                 620                 


Gly Gly Cys Ala Gly Cys Gly Gly Thr Gly Gly Ala Gly Gly Thr Gly 
625                 630                 635                 640 


Gly Thr Thr Cys Thr Gly Gly Gly Gly Gly Thr Gly Gly Cys Gly Gly 
                645                 650                 655     


Thr Ala Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Cys 
            660                 665                 670         


Thr Cys Ala Gly Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Gly Thr 
        675                 680                 685             


Cys Ala Gly Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Cys Ala Gly 
    690                 695                 700                 


Thr Gly Gly Thr Gly Gly Gly Gly Gly Thr Gly Gly Cys Ala Gly Cys 
705                 710                 715                 720 


Gly Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Ala Thr Cys Thr Gly 
                725                 730                 735     


Gly Thr Gly Gly Ala Gly Gly Thr Gly Gly Thr Thr Cys Thr Gly Gly 
            740                 745                 750         


Ala Gly Gly Thr Gly Gly Ala Gly Gly Ala Thr Cys Cys Gly Ala Gly 
        755                 760                 765             


Gly Thr Gly Cys Ala Gly Thr Thr Gly Gly Thr Gly Gly Ala Gly Thr 
    770                 775                 780                 


Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Ala Thr Thr Gly Gly Thr 
785                 790                 795                 800 


Gly Cys Ala Gly Gly Cys Thr Gly Gly Gly Gly Gly Cys Thr Cys Thr 
                805                 810                 815     


Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly Thr Gly 
            820                 825                 830         


Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Cys Gly Cys Ala Cys 
        835                 840                 845             


Cys Thr Thr Cys Thr Cys Gly Ala Gly Gly Thr Ala Thr Cys Ala Gly 
    850                 855                 860                 


Ala Thr Gly Gly Gly Cys Thr Gly Gly Thr Thr Cys Cys Gly Cys Cys 
865                 870                 875                 880 


Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala Gly Gly Ala 
                885                 890                 895     


Gly Cys Gly Thr Gly Ala Gly Thr Thr Thr Gly Thr Ala Gly Cys Ala 
            900                 905                 910         


Thr Ala Thr Ala Thr Thr Ala Gly Cys Thr Gly Gly Ala Gly Thr Gly 
        915                 920                 925             


Gly Thr Ala Gly Thr Ala Cys Ala Cys Gly Thr Thr Ala Thr Gly Thr 
    930                 935                 940                 


Thr Gly Ala Cys Thr Cys Cys Gly Thr Gly Ala Ala Gly Gly Gly Cys 
945                 950                 955                 960 


Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys Cys Ala 
                965                 970                 975     


Gly Ala Gly Ala Cys Ala Ala Cys Gly Cys Cys Ala Ala Gly Ala Ala 
            980                 985                 990         


Cys Ala Cys Gly Gly Thr Gly Thr  Ala Thr Cys Thr Gly  Cys Ala Ala 
        995                 1000                 1005             


Ala Thr  Gly Ala Ala Cys Ala  Gly Cys Cys Thr Gly  Ala Ala Ala 
    1010                 1015                 1020             


Cys Cys  Thr Gly Ala Gly Gly  Ala Cys Ala Cys Gly  Gly Cys Cys 
    1025                 1030                 1035             


Gly Thr  Thr Thr Ala Thr Cys  Ala Cys Thr Gly Thr  Gly Cys Ala 
    1040                 1045                 1050             


Gly Cys  Ala Gly Gly Gly Ala  Cys Gly Gly Cys Cys  Gly Gly Cys 
    1055                 1060                 1065             


Ala Thr  Ala Ala Thr Ala Thr  Cys Thr Ala Gly Thr  Ala Gly Gly 
    1070                 1075                 1080             


Cys Cys  Thr Gly Ala Ala Ala  Cys Thr Thr Ala Thr  Gly Ala Cys 
    1085                 1090                 1095             


Thr Cys  Ala Thr Gly Gly Gly  Gly Cys Cys Ala Gly  Gly Gly Gly 
    1100                 1105                 1110             


Ala Cys  Cys Cys Ala Gly Gly  Thr Cys Ala Cys Cys  Gly Thr Cys 
    1115                 1120                 1125             


Thr Cys  Cys Thr Cys Ala 
    1130                 


<210>  467
<211>  1113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding F010302380(No tag)

<400>  467

Ala Thr Gly Ala Gly Ala Thr Thr Thr Cys Cys Thr Thr Cys Ala Ala 
1               5                   10                  15      


Thr Thr Thr Thr Thr Ala Cys Thr Gly Cys Thr Gly Thr Thr Thr Thr 
            20                  25                  30          


Ala Thr Thr Cys Gly Cys Ala Gly Cys Ala Thr Cys Cys Thr Cys Cys 
        35                  40                  45              


Gly Cys Ala Thr Thr Ala Gly Cys Thr Gly Cys Thr Cys Cys Ala Gly 
    50                  55                  60                  


Thr Cys Ala Ala Cys Ala Cys Thr Ala Cys Ala Ala Cys Ala Gly Ala 
65                  70                  75                  80  


Ala Gly Ala Thr Gly Ala Ala Ala Cys Gly Gly Cys Ala Cys Ala Ala 
                85                  90                  95      


Ala Thr Thr Cys Cys Gly Gly Cys Thr Gly Ala Ala Gly Cys Thr Gly 
            100                 105                 110         


Thr Cys Ala Thr Cys Gly Gly Thr Thr Ala Cys Thr Cys Ala Gly Ala 
        115                 120                 125             


Thr Thr Thr Ala Gly Ala Ala Gly Gly Gly Gly Ala Thr Thr Thr Cys 
    130                 135                 140                 


Gly Ala Thr Gly Thr Thr Gly Cys Thr Gly Thr Thr Thr Thr Gly Cys 
145                 150                 155                 160 


Cys Ala Thr Thr Thr Thr Cys Cys Ala Ala Cys Ala Gly Cys Ala Cys 
                165                 170                 175     


Ala Ala Ala Thr Ala Ala Cys Gly Gly Gly Thr Thr Ala Thr Thr Gly 
            180                 185                 190         


Thr Thr Thr Ala Thr Ala Ala Ala Thr Ala Cys Thr Ala Cys Thr Ala 
        195                 200                 205             


Thr Thr Gly Cys Cys Ala Gly Cys Ala Thr Thr Gly Cys Thr Gly Cys 
    210                 215                 220                 


Thr Ala Ala Ala Gly Ala Ala Gly Ala Ala Gly Gly Gly Gly Thr Ala 
225                 230                 235                 240 


Thr Cys Thr Cys Thr Cys Gly Ala Ala Ala Ala Gly Ala Gly Ala Gly 
                245                 250                 255     


Ala Cys Gly Thr Gly Cys Ala Ala Thr Thr Gly Gly Thr Gly Gly Ala 
            260                 265                 270         


Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Cys Thr Thr Gly 
        275                 280                 285             


Gly Thr Gly Cys Ala Gly Cys Cys Thr Gly Gly Gly Gly Gly Gly Thr 
    290                 295                 300                 


Cys Thr Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly 
305                 310                 315                 320 


Thr Gly Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Ala Gly Cys 
                325                 330                 335     


Ala Thr Cys Thr Thr Cys Ala Ala Thr Ala Thr Cys Ala Ala Cys Ala 
            340                 345                 350         


Gly Thr Ala Thr Gly Gly Cys Cys Thr Gly Gly Thr Ala Thr Cys Gly 
        355                 360                 365             


Cys Cys Gly Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala Gly 
    370                 375                 380                 


Cys Ala Gly Cys Gly Cys Gly Ala Ala Thr Thr Gly Gly Thr Cys Gly 
385                 390                 395                 400 


Cys Ala Ala Gly Thr Ala Gly Cys Ala Cys Cys Ala Ala Thr Gly Gly 
                405                 410                 415     


Thr Gly Gly Thr Ala Gly Thr Ala Cys Ala Ala Ala Cys Thr Ala Thr 
            420                 425                 430         


Gly Cys Ala Gly Ala Cys Thr Cys Cys Gly Thr Gly Ala Ala Gly Gly 
        435                 440                 445             


Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys 
    450                 455                 460                 


Thr Ala Gly Ala Gly Ala Cys Ala Ala Cys Gly Cys Cys Ala Ala Ala 
465                 470                 475                 480 


Cys Gly Gly Gly Thr Gly Thr Ala Thr Cys Thr Gly Cys Ala Ala Ala 
                485                 490                 495     


Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly Ala Cys Ala Cys Cys 
            500                 505                 510         


Thr Gly Ala Gly Gly Ala Cys Ala Cys Gly Gly Cys Cys Gly Thr Cys 
        515                 520                 525             


Thr Ala Thr Thr Ala Thr Thr Gly Thr Cys Gly Thr Gly Cys Ala Cys 
    530                 535                 540                 


Thr Gly Cys Thr Ala Cys Ala Ala Cys Cys Gly Thr Cys Gly Ala Thr 
545                 550                 555                 560 


Thr Thr Ala Thr Gly Ala Cys Ala Thr Thr Ala Gly Thr Cys Gly Cys 
                565                 570                 575     


Ala Cys Ala Thr Ala Thr Thr Gly Gly Gly Gly Cys Cys Ala Gly Gly 
            580                 585                 590         


Gly Gly Ala Cys Cys Cys Thr Gly Gly Thr Cys Ala Cys Gly Gly Thr 
        595                 600                 605             


Cys Thr Cys Cys Thr Cys Cys Gly Gly Ala Gly Gly Thr Gly Gly Thr 
    610                 615                 620                 


Gly Gly Cys Ala Gly Cys Gly Gly Thr Gly Gly Ala Gly Gly Thr Gly 
625                 630                 635                 640 


Gly Thr Thr Cys Thr Gly Gly Gly Gly Gly Thr Gly Gly Cys Gly Gly 
                645                 650                 655     


Thr Ala Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Cys 
            660                 665                 670         


Thr Cys Ala Gly Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Gly Thr 
        675                 680                 685             


Cys Ala Gly Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Cys Ala Gly 
    690                 695                 700                 


Thr Gly Gly Thr Gly Gly Gly Gly Gly Thr Gly Gly Cys Ala Gly Cys 
705                 710                 715                 720 


Gly Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Ala Thr Cys Thr Gly 
                725                 730                 735     


Gly Thr Gly Gly Ala Gly Gly Thr Gly Gly Thr Thr Cys Thr Gly Gly 
            740                 745                 750         


Ala Gly Gly Thr Gly Gly Ala Gly Gly Ala Thr Cys Cys Gly Ala Gly 
        755                 760                 765             


Gly Thr Gly Cys Ala Gly Thr Thr Gly Gly Thr Gly Gly Ala Gly Thr 
    770                 775                 780                 


Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Ala Thr Thr Gly Gly Thr 
785                 790                 795                 800 


Gly Cys Ala Gly Gly Cys Thr Gly Gly Gly Gly Gly Cys Thr Cys Thr 
                805                 810                 815     


Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly Thr Gly 
            820                 825                 830         


Thr Ala Ala Cys Cys Thr Cys Thr Gly Gly Ala Cys Gly Cys Ala Cys 
        835                 840                 845             


Cys Thr Cys Cys Gly Ala Thr Thr Thr Gly Thr Cys Thr Ala Cys Cys 
    850                 855                 860                 


Ala Thr Gly Ala Ala Cys Thr Gly Gly Thr Thr Cys Cys Gly Cys Cys 
865                 870                 875                 880 


Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Ala Ala Ala Gly Gly Ala 
                885                 890                 895     


Gly Cys Gly Thr Gly Ala Gly Thr Thr Thr Gly Thr Cys Gly Cys Ala 
            900                 905                 910         


Cys Gly Cys Ala Thr Cys Ala Cys Thr Cys Gly Gly Cys Gly Thr Gly 
        915                 920                 925             


Gly Thr Ala Gly Cys Ala Cys Ala Thr Ala Cys Thr Ala Thr Gly Cys 
    930                 935                 940                 


Ala Gly Ala Gly Thr Cys Cys Gly Thr Gly Ala Ala Gly Gly Ala Ala 
945                 950                 955                 960 


Cys Gly Ala Thr Thr Cys Ala Thr Cys Ala Thr Cys Thr Cys Cys Ala 
                965                 970                 975     


Gly Ala Gly Ala Cys Ala Ala Cys Gly Cys Cys Ala Ala Gly Ala Ala 
            980                 985                 990         


Cys Ala Cys Gly Gly Thr Gly Thr  Ala Thr Thr Thr Gly  Cys Ala Ala 
        995                 1000                 1005             


Ala Thr  Gly Ala Ala Cys Ala  Gly Cys Cys Thr Gly  Ala Ala Ala 
    1010                 1015                 1020             


Cys Cys  Ala Gly Ala Gly Gly  Ala Cys Ala Cys Gly  Gly Cys Cys 
    1025                 1030                 1035             


Ala Ala  Thr Thr Ala Thr Thr  Ala Cys Thr Gly Thr  Ala Cys Thr 
    1040                 1045                 1050             


Gly Cys  Ala Gly Cys Cys Thr  Cys Ala Gly Ala Ala  Ala Thr Gly 
    1055                 1060                 1065             


Gly Gly  Ala Thr Ala Thr Cys  Ala Cys Thr Ala Cys  Ala Gly Gly 
    1070                 1075                 1080             


Gly Gly  Cys Cys Ala Gly Gly  Gly Gly Ala Cys Cys  Cys Ala Gly 
    1085                 1090                 1095             


Gly Thr  Cys Ala Cys Cys Gly  Thr Cys Thr Cys Cys  Thr Cys Ala 
    1100                 1105                 1110             


<210>  468
<211>  1128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding F010302391 (No tag)

<400>  468

Ala Thr Gly Ala Gly Ala Thr Thr Thr Cys Cys Thr Thr Cys Ala Ala 
1               5                   10                  15      


Thr Thr Thr Thr Thr Ala Cys Thr Gly Cys Thr Gly Thr Thr Thr Thr 
            20                  25                  30          


Ala Thr Thr Cys Gly Cys Ala Gly Cys Ala Thr Cys Cys Thr Cys Cys 
        35                  40                  45              


Gly Cys Ala Thr Thr Ala Gly Cys Thr Gly Cys Thr Cys Cys Ala Gly 
    50                  55                  60                  


Thr Cys Ala Ala Cys Ala Cys Thr Ala Cys Ala Ala Cys Ala Gly Ala 
65                  70                  75                  80  


Ala Gly Ala Thr Gly Ala Ala Ala Cys Gly Gly Cys Ala Cys Ala Ala 
                85                  90                  95      


Ala Thr Thr Cys Cys Gly Gly Cys Thr Gly Ala Ala Gly Cys Thr Gly 
            100                 105                 110         


Thr Cys Ala Thr Cys Gly Gly Thr Thr Ala Cys Thr Cys Ala Gly Ala 
        115                 120                 125             


Thr Thr Thr Ala Gly Ala Ala Gly Gly Gly Gly Ala Thr Thr Thr Cys 
    130                 135                 140                 


Gly Ala Thr Gly Thr Thr Gly Cys Thr Gly Thr Thr Thr Thr Gly Cys 
145                 150                 155                 160 


Cys Ala Thr Thr Thr Thr Cys Cys Ala Ala Cys Ala Gly Cys Ala Cys 
                165                 170                 175     


Ala Ala Ala Thr Ala Ala Cys Gly Gly Gly Thr Thr Ala Thr Thr Gly 
            180                 185                 190         


Thr Thr Thr Ala Thr Ala Ala Ala Thr Ala Cys Thr Ala Cys Thr Ala 
        195                 200                 205             


Thr Thr Gly Cys Cys Ala Gly Cys Ala Thr Thr Gly Cys Thr Gly Cys 
    210                 215                 220                 


Thr Ala Ala Ala Gly Ala Ala Gly Ala Ala Gly Gly Gly Gly Thr Ala 
225                 230                 235                 240 


Thr Cys Thr Cys Thr Cys Gly Ala Ala Ala Ala Gly Ala Gly Ala Gly 
                245                 250                 255     


Ala Cys Gly Thr Gly Cys Ala Ala Thr Thr Gly Gly Thr Gly Gly Ala 
            260                 265                 270         


Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Cys Thr Thr Gly 
        275                 280                 285             


Gly Thr Gly Cys Ala Gly Cys Cys Thr Gly Gly Gly Gly Gly Gly Thr 
    290                 295                 300                 


Cys Thr Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly 
305                 310                 315                 320 


Thr Gly Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Ala Gly Cys 
                325                 330                 335     


Ala Thr Cys Thr Thr Cys Ala Ala Thr Ala Thr Cys Ala Ala Cys Ala 
            340                 345                 350         


Gly Thr Ala Thr Gly Gly Cys Cys Thr Gly Gly Thr Ala Thr Cys Gly 
        355                 360                 365             


Cys Cys Gly Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala Gly 
    370                 375                 380                 


Cys Ala Gly Cys Gly Cys Gly Ala Ala Thr Thr Gly Gly Thr Cys Gly 
385                 390                 395                 400 


Cys Ala Ala Gly Thr Ala Gly Cys Ala Cys Cys Ala Ala Thr Gly Gly 
                405                 410                 415     


Thr Gly Gly Thr Ala Gly Thr Ala Cys Ala Ala Ala Cys Thr Ala Thr 
            420                 425                 430         


Gly Cys Ala Gly Ala Cys Thr Cys Cys Gly Thr Gly Ala Ala Gly Gly 
        435                 440                 445             


Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys 
    450                 455                 460                 


Thr Ala Gly Ala Gly Ala Cys Ala Ala Cys Gly Cys Cys Ala Ala Ala 
465                 470                 475                 480 


Cys Gly Gly Gly Thr Gly Thr Ala Thr Cys Thr Gly Cys Ala Ala Ala 
                485                 490                 495     


Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly Ala Cys Ala Cys Cys 
            500                 505                 510         


Thr Gly Ala Gly Gly Ala Cys Ala Cys Gly Gly Cys Cys Gly Thr Cys 
        515                 520                 525             


Thr Ala Thr Thr Ala Thr Thr Gly Thr Cys Gly Thr Gly Cys Ala Cys 
    530                 535                 540                 


Thr Gly Cys Thr Ala Cys Ala Ala Cys Cys Gly Thr Cys Gly Ala Thr 
545                 550                 555                 560 


Thr Thr Ala Thr Gly Ala Cys Ala Thr Thr Ala Gly Thr Cys Gly Cys 
                565                 570                 575     


Ala Cys Ala Thr Ala Thr Thr Gly Gly Gly Gly Cys Cys Ala Gly Gly 
            580                 585                 590         


Gly Gly Ala Cys Cys Cys Thr Gly Gly Thr Cys Ala Cys Gly Gly Thr 
        595                 600                 605             


Cys Thr Cys Cys Thr Cys Cys Gly Gly Ala Gly Gly Thr Gly Gly Thr 
    610                 615                 620                 


Gly Gly Cys Ala Gly Cys Gly Gly Thr Gly Gly Ala Gly Gly Thr Gly 
625                 630                 635                 640 


Gly Thr Thr Cys Thr Gly Gly Gly Gly Gly Thr Gly Gly Cys Gly Gly 
                645                 650                 655     


Thr Ala Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Cys 
            660                 665                 670         


Thr Cys Ala Gly Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Gly Thr 
        675                 680                 685             


Cys Ala Gly Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Cys Ala Gly 
    690                 695                 700                 


Thr Gly Gly Thr Gly Gly Gly Gly Gly Thr Gly Gly Cys Ala Gly Cys 
705                 710                 715                 720 


Gly Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Ala Thr Cys Thr Gly 
                725                 730                 735     


Gly Thr Gly Gly Ala Gly Gly Thr Gly Gly Thr Thr Cys Thr Gly Gly 
            740                 745                 750         


Ala Gly Gly Thr Gly Gly Ala Gly Gly Ala Thr Cys Cys Gly Ala Gly 
        755                 760                 765             


Gly Thr Gly Cys Ala Gly Thr Thr Gly Gly Thr Gly Gly Ala Gly Thr 
    770                 775                 780                 


Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Ala Thr Thr Gly Gly Thr 
785                 790                 795                 800 


Gly Cys Ala Gly Gly Cys Thr Gly Gly Gly Gly Gly Cys Thr Cys Thr 
                805                 810                 815     


Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly Thr Gly 
            820                 825                 830         


Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Cys Gly Cys Ala Cys 
        835                 840                 845             


Cys Gly Cys Thr Ala Gly Thr Ala Thr Cys Thr Ala Thr Gly Cys Cys 
    850                 855                 860                 


Ala Thr Gly Gly Cys Cys Thr Gly Gly Thr Thr Cys Cys Gly Cys Cys 
865                 870                 875                 880 


Ala Gly Gly Cys Thr Cys Ala Gly Gly Gly Gly Ala Ala Gly Gly Ala 
                885                 890                 895     


Gly Cys Gly Thr Gly Ala Ala Thr Thr Thr Gly Thr Cys Gly Cys Ala 
            900                 905                 910         


Gly Thr Thr Ala Thr Thr Ala Cys Cys Cys Gly Gly Ala Gly Thr Gly 
        915                 920                 925             


Gly Thr Gly Gly Ala Ala Cys Gly Ala Thr Cys Gly Thr Cys Thr Ala 
    930                 935                 940                 


Thr Gly Cys Ala Gly Ala Cys Thr Cys Cys Gly Thr Gly Ala Ala Gly 
945                 950                 955                 960 


Gly Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr 
                965                 970                 975     


Cys Cys Ala Gly Ala Gly Ala Cys Gly Ala Cys Gly Cys Cys Ala Ala 
            980                 985                 990         


Gly Ala Ala Cys Ala Cys Thr Gly  Thr Gly Thr Gly Gly  Thr Thr Gly 
        995                 1000                 1005             


Cys Ala  Ala Ala Thr Gly Ala  Gly Cys Gly Cys Thr  Cys Thr Gly 
    1010                 1015                 1020             


Ala Gly  Ala Cys Cys Thr Gly  Ala Gly Gly Ala Cys  Ala Cys Ala 
    1025                 1030                 1035             


Gly Cys  Cys Gly Thr Ala Thr  Ala Thr Thr Thr Cys  Thr Gly Thr 
    1040                 1045                 1050             


Ala Ala  Thr Gly Cys Gly Gly  Thr Thr Gly Cys Gly  Gly Thr Cys 
    1055                 1060                 1065             


Gly Ala  Ala Gly Ala Cys Gly  Gly Gly Ala Thr Gly  Ala Ala Cys 
    1070                 1075                 1080             


Gly Thr  Thr Ala Thr Gly Ala  Ala Thr Thr Ala Thr  Thr Gly Gly 
    1085                 1090                 1095             


Gly Gly  Cys Cys Ala Gly Gly  Gly Gly Ala Cys Cys  Cys Thr Gly 
    1100                 1105                 1110             


Gly Thr  Cys Ala Cys Cys Gly  Thr Cys Thr Cys Cys  Thr Cys Ala 
    1115                 1120                 1125             


<210>  469
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 HC constant domain

<400>  469

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  470
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 HC Constant domain (L234A L235A D265S)

<400>  470

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Ser Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  471
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 HC Constant domain (L234A L235A P329G)

<400>  471

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Ser Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  472
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 HC Constant domain (L235E)

<400>  472

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  473
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 HC Constant domain (D265A)

<400>  473

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  474
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 HC Constant domain (D265A N297G)

<400>  474

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  475
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 HC Constant domain (E233A/L235A)

<400>  475

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Ala Leu Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  476
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 HC Constant domain

<400>  476

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  477
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 HC Constant domain (D265S)

<400>  477

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ser 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  478
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 HC Constant domain (P329G)

<400>  478

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Gly 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  479
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 HC Constant domain (D265A)

<400>  479

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  480
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 HC Constant domain (D265A N297G)

<400>  480

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gly 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  481
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 HC Constant domain (V234A G237A P238S H268A V309L 
       A330S P331S X378S/A)(See IgGsigma SEQ ID No:78 in WO2017079112)


<220>
<221>  misc_feature
<222>  (257)..(257)
<223>  Xaa can be any naturally occurring amino acid

<400>  481

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Ala Ala Ala Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser Ala Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Xaa Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  482
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 HC Constant domain (S228P)

<400>  482

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  483
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 HC Constant domain (S228P P329G)

<400>  483

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Gly Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  484
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 HC Constant domain (S228P D265A)

<400>  484

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Ala Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  485
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 HC Constant domain (S228P D265A N297G)

<400>  485

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Ala Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  486
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301657

<400>  486

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Leu Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg 
        35                  40                  45              


Pro Phe Ser Thr Ser Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys 
    50                  55                  60                  


Glu Arg Glu Ala Val Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Glu Val Tyr Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Leu Asp Arg Ala Tyr Gln Gly Arg Ser Phe 
        115                 120                 125             


Ser Ala Lys Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  487
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301658

<400>  487

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Leu Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg 
        35                  40                  45              


Pro Phe Ser Thr Ser Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys 
    50                  55                  60                  


Glu Arg Glu Ala Val Ala Ala Ile Leu Trp Asn Gly Ile Val Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Glu Val Tyr Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Leu Asp Arg Ala Tyr Gln Gly Arg Ser Phe 
        115                 120                 125             


Ser Ala Lys Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  488
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301659

<400>  488

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Leu Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg 
        35                  40                  45              


Pro Phe Ser Thr Ser Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys 
    50                  55                  60                  


Glu Arg Glu Ala Val Ala Ala Ile Leu Trp Asn Gly Ile Val Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Glu Val Tyr Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Leu Asp Arg Ala Tyr Gly Gly Arg Ser Phe 
        115                 120                 125             


Ser Ala Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  489
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301661

<400>  489

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Leu Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg 
        35                  40                  45              


Pro Phe Ser Thr Ser Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys 
    50                  55                  60                  


Glu Arg Glu Ala Val Ala Ala Ile Leu Trp Asn Gly Ile Val Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Glu Val Tyr Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe 
        115                 120                 125             


Ser Ala Lys Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  490
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301662

<400>  490

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Leu Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg 
        35                  40                  45              


Pro Phe Ser Thr Ser Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys 
    50                  55                  60                  


Glu Arg Glu Ala Val Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Glu Val Tyr Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Leu Asp Arg Ala Tyr Gln Gly Arg Ser Phe 
        115                 120                 125             


Ser Ala Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala 
145         


<210>  491
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301663

<400>  491

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Leu Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg 
        35                  40                  45              


Pro Phe Ser Thr Ser Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys 
    50                  55                  60                  


Glu Arg Glu Ala Val Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Glu Val Tyr Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Leu Asp Arg Ala Tyr Gly Gly Arg Ser Phe 
        115                 120                 125             


Ser Ala Lys Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  492
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301664

<400>  492

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Leu Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg 
        35                  40                  45              


Pro Phe Ser Thr Ser Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys 
    50                  55                  60                  


Glu Arg Glu Ala Val Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Glu Val Tyr Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Leu Asp Arg Asp Tyr Gln Gly Arg Ser Phe 
        115                 120                 125             


Ser Ala Lys Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  493
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301665

<400>  493

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Leu Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg 
        35                  40                  45              


Pro Phe Ser Thr Ser Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys 
    50                  55                  60                  


Glu Arg Glu Ala Val Ala Ala Ile Leu Trp Asn Gly Ile Val Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Glu Val Tyr Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Leu Asp Arg Ala Tyr Gly Gly Arg Ser Phe 
        115                 120                 125             


Ser Ala Lys Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


<210>  494
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301666

<400>  494

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Leu Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg 
        35                  40                  45              


Pro Phe Ser Thr Ser Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys 
    50                  55                  60                  


Glu Arg Glu Ala Val Ala Ala Ile Leu Trp Asn Gly Ile Val Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Glu Val Tyr Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Leu Asp Arg Asp Tyr Gln Gly Arg Ser Phe 
        115                 120                 125             


Ser Ala Lys Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  495
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301867

<400>  495

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Gln Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  496
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301878

<400>  496

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Glu Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  497
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301879

<400>  497

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gln Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  498
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301880

<400>  498

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Ser Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  499
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301881

<400>  499

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Trp Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  500
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301882

<400>  500

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Val Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  501
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301883

<400>  501

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Val Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  502
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301884

<400>  502

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Ala Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  503
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301885

<400>  503

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Glu Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  504
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301886

<400>  504

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Gln Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  505
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301887

<400>  505

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Gln Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  506
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301888

<400>  506

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr His Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  507
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301889

<400>  507

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ala Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  508
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301890

<400>  508

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Val Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Thr Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  509
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301891

<400>  509

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Thr Ser Arg Ala Phe Ile Arg Asp 
            20                  25                  30          


Val Phe Thr Gly Trp Tyr Arg Arg Val Pro Gly Lys Glu Arg Glu Leu 
        35                  40                  45              


Val Ala Arg Ile Tyr Asn Gly Gly Asn Val Asn Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Met Val Thr 
65                  70                  75                  80  


Leu Arg Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Leu Phe Ser Gly Thr Ile Asn Thr Gly Arg Glu Tyr Arg Ser Gly Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  510
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010300534

<400>  510

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Ala Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Tyr Val Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ser 
                85                  90                  95      


Leu Ser Arg Tyr Leu Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  511
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010300535

<400>  511

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Ala Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Trp Gly Gly Tyr Thr Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ser 
                85                  90                  95      


Leu Ser Arg Tyr Leu Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  512
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010300536

<400>  512

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Ala Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Tyr Thr Thr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ser 
                85                  90                  95      


Leu Ser Arg Tyr Leu Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  513
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301055

<400>  513

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Ala Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Trp Gly Gly Tyr Val Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ser 
                85                  90                  95      


Leu Ser Arg Tyr Leu Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  514
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301059

<400>  514

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Ala Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Tyr Val Asn Tyr Asn Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Leu Ser Arg Tyr Gln Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  515
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301080

<400>  515

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Ala Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Trp Gly Gly Tyr Val Thr Tyr Asn Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ser 
                85                  90                  95      


Leu Ser Arg Tyr Leu Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  516
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301090

<400>  516

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Ala Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Trp Thr Thr Tyr Asn Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ser 
                85                  90                  95      


Leu Ser Arg Tyr Gln Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  517
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301099

<400>  517

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Ala Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Trp Val Thr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ser 
                85                  90                  95      


Leu Ser Arg Tyr Leu Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  518
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301111

<400>  518

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Ala Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Tyr Val Asn Tyr Asn Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Leu Ser Arg Tyr Leu Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  519
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301113

<400>  519

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Arg Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Tyr Thr Asn Tyr Asn Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ser 
                85                  90                  95      


Leu Ser Val Tyr Gln Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  520
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301126

<400>  520

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Arg Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Tyr Val Thr Tyr Asn Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ser 
                85                  90                  95      


Leu Ser Arg Tyr Leu Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  521
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301129

<400>  521

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Ala Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Trp Thr Asn Tyr Asn Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Leu Ser Arg Tyr Gln Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  522
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301138

<400>  522

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Tyr Ala Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Tyr Thr Asn Tyr Asn Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Leu Ser Arg Tyr Gln Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  523
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301139

<400>  523

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Arg Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Trp Phe Ser Gly Gly Tyr Val Asn Tyr Asn Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ser 
                85                  90                  95      


Leu Ser Arg Tyr Gln Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  524
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301162

<400>  524

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Arg Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Trp Thr Asn Tyr Asn Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ser 
                85                  90                  95      


Leu Ser Arg Tyr Gln Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  525
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301175

<400>  525

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Arg Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Tyr Thr Thr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ser 
                85                  90                  95      


Leu Ser Arg Tyr Leu Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  526
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301188

<400>  526

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Arg Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Tyr Thr Asn Tyr Asn Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ser 
                85                  90                  95      


Leu Ser Arg Tyr Gln Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  527
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301191

<400>  527

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Arg Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Trp Thr Asn Tyr Asn Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Leu Ser Val Tyr Gln Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  528
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301232

<400>  528

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Arg Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Tyr Thr Thr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Leu Ser Arg Tyr Gln Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  529
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301458

<400>  529

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Arg Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Trp Thr Asn Tyr Asn Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Leu Ser Arg Tyr Gln Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  530
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301463

<400>  530

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Met Leu Phe Asn Arg Asn 
            20                  25                  30          


Thr Gln Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Phe Ile Phe Ser Gly Gly Tyr Thr Asn Tyr Asn Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Leu Ser Arg Tyr Gln Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  531
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301301

<400>  531

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Thr Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  532
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301304

<400>  532

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Trp Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  533
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301309

<400>  533

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Val Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  534
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301313

<400>  534

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Lys Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  535
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301314

<400>  535

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  536
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301328

<400>  536

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Val Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  537
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301335

<400>  537

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  538
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301344

<400>  538

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Gly Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  539
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301346

<400>  539

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Gly Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  540
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301350

<400>  540

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Val Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  541
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301360

<400>  541

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Thr Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  542
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301367

<400>  542

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Gly Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  543
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301372

<400>  543

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Gly Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  544
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301387

<400>  544

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Ala Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  545
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301409

<400>  545

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile Val Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  546
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301416

<400>  546

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Gln 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  547
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301418

<400>  547

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Trp Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  548
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301425

<400>  548

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Val Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  549
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301440

<400>  549

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Thr Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  550
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301445

<400>  550

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Tyr Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  551
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301557

<400>  551

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Gly Gly Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  552
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301558

<400>  552

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Gly Asp Ser Ala Thr Gly Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  553
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301559

<400>  553

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Gly Ser Ala Thr Gly Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  554
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301560

<400>  554

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Gly Gly Ser Ala Thr Gly Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  555
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301561

<400>  555

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Gly Asp Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  556
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301562

<400>  556

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Gly Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  557
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301564

<400>  557

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Gly Gly Ser Ala Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  558
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301565

<400>  558

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Gly Asp Ser Ala Thr Gly Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  559
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301566

<400>  559

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Arg Ile Leu Arg Ile Gly 
            20                  25                  30          


Tyr Met Arg Trp His Arg Gln Gly Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Asp Gly Ser Ala Thr Gly Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
                85                  90                  95      


Ala Leu Val Thr Ala Ser Val Arg Gly Gly Ser Ile His Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  560
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301567

<400>  560

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Tyr Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  561
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301568

<400>  561

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Thr Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  562
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301574

<400>  562

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  563
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301578

<400>  563

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Gly Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  564
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301579

<400>  564

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Lys Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  565
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301580

<400>  565

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Thr Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  566
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301584

<400>  566

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Thr Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  567
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301585

<400>  567

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Pro Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  568
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301586

<400>  568

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Ala Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  569
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301589

<400>  569

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Pro Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  570
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301591

<400>  570

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Lys Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  571
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301592

<400>  571

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Ser Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  572
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301593

<400>  572

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Lys Asp Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  573
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301594

<400>  573

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Lys Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  574
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301595

<400>  574

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Ala Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  575
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301596

<400>  575

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Ala Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  576
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301598

<400>  576

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gln Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  577
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301604

<400>  577

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Gln Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  578
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301606

<400>  578

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Lys Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  579
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301607

<400>  579

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Ala Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  580
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301609

<400>  580

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Gln Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  581
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301612

<400>  581

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Thr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  582
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301617

<400>  582

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Gln Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  583
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301618

<400>  583

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  584
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301619

<400>  584

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Lys Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  585
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301621

<400>  585

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Gly Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  586
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301622

<400>  586

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Asp Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  587
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301627

<400>  587

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Ala Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  588
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301629

<400>  588

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Arg Pro Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Glu Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Ser Ile Leu Trp Asn Gly Ile Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Arg Asp Tyr Gly Gly Arg Ser Phe Ser Ala Tyr Glu Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  589
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010300316

<400>  589

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Trp Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  590
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010300468

<400>  590

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  591
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010300477

<400>  591

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Trp 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  592
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010300631

<400>  592

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Ser Thr Pro Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  593
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010300659

<400>  593

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Ser Thr Pro Gly Trp Asp Trp Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Trp 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  594
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010300684

<400>  594

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Trp Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Pro Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Ile Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  595
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010300796

<400>  595

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Ser Thr Pro Gly Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  596
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010300880

<400>  596

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Pro Gly Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Trp 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  597
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010300900

<400>  597

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Pro Gly Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Trp 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Ile Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  598
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010300948

<400>  598

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Pro Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Trp 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Ile Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  599
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010300990

<400>  599

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Ser Thr Pro Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Ile Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  600
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301000

<400>  600

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Ser Thr Pro Gly Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Ile Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  601
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301459

<400>  601

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ser Thr Pro Gly Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  602
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301460

<400>  602

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Ser Thr Pro Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  603
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F010301462

<400>  603

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Val Phe Asn Ile Asn 
            20                  25                  30          


Arg Met Ala Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Ser Thr Pro Gly Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala 
                85                  90                  95      


Leu Leu Gln Pro Ser Ile Tyr Asp Ile Ser Arg Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


