                         SEQUENCE LISTING

<110>  NERD BIO LLC
 
<120>  HIGH THROUGHPUT DRUG SCREENING METHODS

<130>  062554-0562965

<150>  63/114,927
<151>  2020-11-17

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1

Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser Ser 
1               5                   10                  15      


Thr Ser Ala Ala 
            20  


<210>  2
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  2

Lys Glu Thr Asn Trp Ala Trp Phe Trp Asp Gln His Met Asp Ser Ser 
1               5                   10                  15      


Thr Ser Ala 
            


<210>  3
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  3

Lys Glu Thr Gly Trp Ala Leu Phe Val Gln Gln His Met Asp Ser Ser 
1               5                   10                  15      


Thr Ser Ala 
            


<210>  4
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  4

Lys Glu Thr Val Met Ala Asn Phe Gln Met Gln His Met Asp Ser Ser 
1               5                   10                  15      


Thr Ser Ala 
            


<210>  5
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  5

Lys Glu Thr Gly Asp Ala Val Phe Ala Arg Gln His Met Asp Ser Ser 
1               5                   10                  15      


Thr Ser Ala 
            


<210>  6
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  6

Lys Glu Thr Gly Trp Ala Ala Phe Val Lys Gln His Met Asp Ser Ser 
1               5                   10                  15      


Thr Ser Ala 
            


<210>  7
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  7

Lys Glu Thr Gly Trp Ala Thr Phe Val Glu Gln His Met Asp Ser Ser 
1               5                   10                  15      


Thr Ser Ala 
            


<210>  8
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  8

Lys Glu Thr Lys Leu Ala Phe Phe Leu Lys Gln His Met Asp Ser Ser 
1               5                   10                  15      


Thr Ser Ala 
            


<210>  9
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  9

Lys Glu Thr Trp Trp Ala Trp Phe Phe Gly Gln His Met Asp Ser Ser 
1               5                   10                  15      


Thr Ser Ala 
            


<210>  10
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  10

Lys Glu Thr Thr Trp Ala Glu Phe Thr Trp Gln His Met Asp Ser Ser 
1               5                   10                  15      


Thr Ser Ala 
            


<210>  11
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  11

Lys Glu Thr Pro Trp Ala Ser Phe Asn Lys Gln His Met Asp Ser Ser 
1               5                   10                  15      


Thr Ser Ala 
            


<210>  12
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  12

Lys Glu Thr Ala Met Ala Met Phe Val Thr Gln His Met Asp Ser Ser 
1               5                   10                  15      


Thr Ser Ala 
            


<210>  13
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  13

Lys Glu Thr Leu Trp Ala Trp Phe Met Trp Gln His Met Asp Ser Ser 
1               5                   10                  15      


Thr Ser Ala 
            


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  14

Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  15

Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asn Ser 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  16

Asn Arg Ala Trp Ser Glu Phe Leu Trp Gln His Leu Ala Pro Val 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  17

Asn Arg Gly Trp Ser Glu Phe Leu Trp Gln His His Ala Pro Val 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  18

Asn Arg Ala Trp Ser Val Phe Gln Trp Gln His Ile Ala Pro Ala 
1               5                   10                  15  


<210>  19
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  19

Met Ser Ser Ser Asn Tyr Cys Asn Gln Met Met Lys Ser Arg Asn Leu 
1               5                   10                  15      


Thr Lys Asp Arg Cys Lys Pro Val Asn Thr Phe Val His Glu Ser Leu 
            20                  25                  30          


Ala Asp Val Gln Ala Val Cys Ser Gln Lys Asn Val Ala Cys Lys Asn 
        35                  40                  45              


Gly Gln Thr Asn Cys Tyr Gln Ser Tyr Ser Thr Met Ser Ile Thr Asp 
    50                  55                  60                  


Cys Arg Glu Thr Gly Ser Ser Lys Tyr Pro Asn Cys Ala Tyr Lys Thr 
65                  70                  75                  80  


Thr Gln Ala Asn Lys His Ile Ile Val Ala Cys Glu Gly Asn Pro Tyr 
                85                  90                  95      


Val Pro Val His Phe Asp Ala Ser Val 
            100                 105 


<210>  20
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  20

Met Ser Ser Ser Asn Tyr Cys Asn Gln Met Met Lys Ser Arg Asn Leu 
1               5                   10                  15      


Thr Lys Asp Arg Cys Lys Pro Val Asn Thr Phe Val His Glu Ser Leu 
            20                  25                  30          


Ala Asp Val Gln Ala Val Cys Ser Gln Lys Asn Val Ala Cys Lys Asn 
        35                  40                  45              


Gly Gln Thr Asn Cys Tyr Gln Ser Tyr Ser Thr Met Ser Ile Thr Asp 
    50                  55                  60                  


Cys Arg Glu Thr Gly Ser Ser Lys Tyr Pro Asn Cys Ala Tyr Lys Thr 
65                  70                  75                  80  


Thr Gln Ala Asn Lys His Ile Ile Val Ala Cys Glu Gly Asn Pro Tyr 
                85                  90                  95      


Val Pro Val His Phe Asp 
            100         


<210>  21
<211>  124
<212>  PRT
<213>  Bos taurus

<400>  21

Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser Ser 
1               5                   10                  15      


Thr Ser Ala Ala Ser Ser Ser Asn Tyr Cys Asn Gln Met Met Lys Ser 
            20                  25                  30          


Arg Asn Leu Thr Lys Asp Arg Cys Lys Pro Val Asn Thr Phe Val His 
        35                  40                  45              


Glu Ser Leu Ala Asp Val Gln Ala Val Cys Ser Gln Lys Asn Val Ala 
    50                  55                  60                  


Cys Lys Asn Gly Gln Thr Asn Cys Tyr Gln Ser Tyr Ser Thr Met Ser 
65                  70                  75                  80  


Ile Thr Asp Cys Arg Glu Thr Gly Ser Ser Lys Tyr Pro Asn Cys Ala 
                85                  90                  95      


Tyr Lys Thr Thr Gln Ala Asn Lys His Ile Ile Val Ala Cys Glu Gly 
            100                 105                 110         


Asn Pro Tyr Val Pro Val His Phe Asp Ala Ser Val 
        115                 120                 


<210>  22
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  22
ggtaccatga gcagctccaa ctactgtaac cagatgatga agagccggaa cctgaccaaa       60

gatcgatgca agccagtgaa cacctttgtg cacgagtccc tggctgatgt ccaggccgtg      120

tgctcccaga aaaatgttgc ctgcaagaat gggcagacca attgctacca gagctactcc      180

accatgagca tcaccgactg ccgtgagacc ggcagctcca agtaccccaa ctgtgcctac      240

aagaccaccc aggcgaataa acacatcatt gtggcttgtg agggaaaccc gtacgtgcca      300

gtccactttg atgcttcagt gcatcaccat caccatcact agggatcc                   348


<210>  23
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  23

Met Ser Ser Ser Asn Tyr Cys Asn Gln Met Met Lys Ser Arg Asn Leu 
1               5                   10                  15      


Thr Lys Asp Arg Cys Lys Pro Val Asn Thr Phe Val His Glu Ser Leu 
            20                  25                  30          


Ala Asp Val Gln Ala Val Cys Ser Gln Lys Asn Val Ala Cys Lys Asn 
        35                  40                  45              


Gly Gln Thr Asn Cys Tyr Gln Ser Tyr Ser Thr Met Ser Ile Thr Asp 
    50                  55                  60                  


Cys Arg Glu Thr Gly Ser Ser Lys Tyr Pro Asn Cys Ala Tyr Lys Thr 
65                  70                  75                  80  


Thr Gln Ala Asn Lys His Ile Ile Val Ala Cys Glu Gly Asn Pro Tyr 
                85                  90                  95      


Val Pro Val His Phe Asp Ala Ser Val His His His His His His 
            100                 105                 110     


<210>  24
<211>  552
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  24
ggtaccatgg gcgcctccag gctctatacc ctggtgctgg tcctgcagcc tcagcgagtt       60

ctcctgggca tgaaaaagcg aggcttcggg gccggccggt ggaatggctt tgggggcaaa      120

gtgcaagaag gagagaccat cgaggatggg gctaggaggg agctgcagga ggagagcggt      180

ctgacagtgg acgccctgca caaggtgggc cagatcgtgt ttgagttcgt gggcgagcct      240

gagctcatgg acgtgcatgt cttctgcaca gacagcatcc aggggacccc cgtggagagc      300

gacgaaatgc gcccatgctg gttccagctg gatcagatcc ccttcaagga catgtggccc      360

gacgacagct actggtttcc actcctgctt cagaagaaga aattccacgg gtacttcaag      420

ttccagggtc aggacaccat cctggactac acactccgcg aggtggacac ggtcaaggaa      480

actgcagcag ccaagtttga gcggcagcac atggactcca gcacttccgc tgcctaggct      540

gcctagggat cc                                                          552


<210>  25
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  25

Met Gly Ala Ser Arg Leu Tyr Thr Leu Val Leu Val Leu Gln Pro Gln 
1               5                   10                  15      


Arg Val Leu Leu Gly Met Lys Lys Arg Gly Phe Gly Ala Gly Arg Trp 
            20                  25                  30          


Asn Gly Phe Gly Gly Lys Val Gln Glu Gly Glu Thr Ile Glu Asp Gly 
        35                  40                  45              


Ala Arg Arg Glu Leu Gln Glu Glu Ser Gly Leu Thr Val Asp Ala Leu 
    50                  55                  60                  


His Lys Val Gly Gln Ile Val Phe Glu Phe Val Gly Glu Pro Glu Leu 
65                  70                  75                  80  


Met Asp Val His Val Phe Cys Thr Asp Ser Ile Gln Gly Thr Pro Val 
                85                  90                  95      


Glu Ser Asp Glu Met Arg Pro Cys Trp Phe Gln Leu Asp Gln Ile Pro 
            100                 105                 110         


Phe Lys Asp Met Trp Pro Asp Asp Ser Tyr Trp Phe Pro Leu Leu Leu 
        115                 120                 125             


Gln Lys Lys Lys Phe His Gly Tyr Phe Lys Phe Gln Gly Gln Asp Thr 
    130                 135                 140                 


Ile Leu Asp Tyr Thr Leu Arg Glu Val Asp Thr Val Lys Glu Thr Ala 
145                 150                 155                 160 


Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser Ser Thr Ser Ala Ala 
                165                 170                 175     


<210>  26
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  26
ggtaccatgg gcgcctccag gctctatacc ctggtgctgg tcctgcagcc tcagcgagtt       60

ctcctgggca tgaaaaagcg aggcttcggg gccggccggt ggaatggctt tgggggcaaa      120

gtgcaagaag gagagaccat cgaggatggg gctaggaggg agctgcagga ggagagcggt      180

ctgacagtgg acgccctgca caaggtgggc cagatcgtgt ttgagttcgt gggcgagcct      240

gagctcatgg acgtgcatgt cttctgcaca gacagcatcc aggggacccc cgtggagagc      300

gacgaaatgc gcccatgctg gttccagctg gatcagatcc ccttcaagga catgtggccc      360

gacgacagct actggtttcc actcctgctt cagaagaaga aattccacgg gtacttcaag      420

ttccagggtc aggacaccat cctggactac acactccgcg aggtggacac ggtcgccgcc      480

gccaaggaaa ctgcagcagc caagtttgag cggcagcaca tggactccag cacttccgct      540

gcctaggctg cctagggatc c                                                561


<210>  27
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  27

Met Gly Ala Ser Arg Leu Tyr Thr Leu Val Leu Val Leu Gln Pro Gln 
1               5                   10                  15      


Arg Val Leu Leu Gly Met Lys Lys Arg Gly Phe Gly Ala Gly Arg Trp 
            20                  25                  30          


Asn Gly Phe Gly Gly Lys Val Gln Glu Gly Glu Thr Ile Glu Asp Gly 
        35                  40                  45              


Ala Arg Arg Glu Leu Gln Glu Glu Ser Gly Leu Thr Val Asp Ala Leu 
    50                  55                  60                  


His Lys Val Gly Gln Ile Val Phe Glu Phe Val Gly Glu Pro Glu Leu 
65                  70                  75                  80  


Met Asp Val His Val Phe Cys Thr Asp Ser Ile Gln Gly Thr Pro Val 
                85                  90                  95      


Glu Ser Asp Glu Met Arg Pro Cys Trp Phe Gln Leu Asp Gln Ile Pro 
            100                 105                 110         


Phe Lys Asp Met Trp Pro Asp Asp Ser Tyr Trp Phe Pro Leu Leu Leu 
        115                 120                 125             


Gln Lys Lys Lys Phe His Gly Tyr Phe Lys Phe Gln Gly Gln Asp Thr 
    130                 135                 140                 


Ile Leu Asp Tyr Thr Leu Arg Glu Val Asp Thr Val Ala Ala Ala Lys 
145                 150                 155                 160 


Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser Ser Thr 
                165                 170                 175     


Ser Ala Ala 
            


<210>  28
<211>  582
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  28
ggtaccatgg gcgcctccag gctctatacc ctggtgctgg tcctgcagcc tcagcgagtt       60

ctcctgggca tgaaaaagcg aggcttcggg gccggccggt ggaatggctt tgggggcaaa      120

gtgcaagaag gagagaccat cgaggatggg gctaggaggg agctgcagga ggagagcggt      180

ctgacagtgg acgccctgca caaggtgggc cagatcgtgt ttgagttcgt gggcgagcct      240

gagctcatgg acgtgcatgt cttctgcaca gacagcatcc aggggacccc cgtggagagc      300

gacgaaatgc gcccatgctg gttccagctg gatcagatcc ccttcaagga catgtggccc      360

gacgacagct actggtttcc actcctgctt cagaagaaga aattccacgg gtacttcaag      420

ttccagggtc aggacaccat cctggactac acactccgcg aggtggacac ggtcgccgcc      480

gccgccgccg ccgccgccgc cgccaaggaa actgcagcag ccaagtttga gcggcagcac      540

atggactcca gcacttccgc tgcctaggct gcctagggat cc                         582


<210>  29
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  29

Met Gly Ala Ser Arg Leu Tyr Thr Leu Val Leu Val Leu Gln Pro Gln 
1               5                   10                  15      


Arg Val Leu Leu Gly Met Lys Lys Arg Gly Phe Gly Ala Gly Arg Trp 
            20                  25                  30          


Asn Gly Phe Gly Gly Lys Val Gln Glu Gly Glu Thr Ile Glu Asp Gly 
        35                  40                  45              


Ala Arg Arg Glu Leu Gln Glu Glu Ser Gly Leu Thr Val Asp Ala Leu 
    50                  55                  60                  


His Lys Val Gly Gln Ile Val Phe Glu Phe Val Gly Glu Pro Glu Leu 
65                  70                  75                  80  


Met Asp Val His Val Phe Cys Thr Asp Ser Ile Gln Gly Thr Pro Val 
                85                  90                  95      


Glu Ser Asp Glu Met Arg Pro Cys Trp Phe Gln Leu Asp Gln Ile Pro 
            100                 105                 110         


Phe Lys Asp Met Trp Pro Asp Asp Ser Tyr Trp Phe Pro Leu Leu Leu 
        115                 120                 125             


Gln Lys Lys Lys Phe His Gly Tyr Phe Lys Phe Gln Gly Gln Asp Thr 
    130                 135                 140                 


Ile Leu Asp Tyr Thr Leu Arg Glu Val Asp Thr Val Ala Ala Ala Ala 
145                 150                 155                 160 


Ala Ala Ala Ala Ala Ala Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg 
                165                 170                 175     


Gln His Met Asp Ser Ser Thr Ser Ala Ala 
            180                 185     


<210>  30
<211>  2181
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  30
atggcctcgc cggctgacag ctgtatccag ttcacccgcc atgccagtga tgttcttctc       60

aaccttaatc gtctccggag tcgagacatc ttgactgatg ttgtcattgt tgtgagccgt      120

gagcagttta gagcccataa aacggtcctc atggcctgca gtggcctgtt ctatagcatc      180

tttacagacc agttgaaatg caaccttagt gtgatcaatc tagatcctga gatcaaccct      240

gagggattct gcatcctcct ggacttcatg tacacatctc ggctcaattt gcgggagggc      300

aacatcatgg ctgtgatggc cacggctatg tacctgcaga tggagcatgt tgtggacact      360

tgccggaagt ttattaaggc cagtgaagca gagatggttt ctgccatcaa gcctcctcgt      420

gaagagttcc tcaacagccg gatgctgatg ccccaagaca tcatggccta tcggggtcgt      480

gaggtggtgg agaacaacct gccactgagg agcgcccctg ggtgtgagag cagagccttt      540

gcccccagcc tgtacagtgg cctgtccaca ccgccagcct cttattccat gtacagccac      600

ctccctgtca gcagcctcct cttctccgat gaggagtttc gggatgtccg gatgcctgtg      660

gccaacccct tccccaagga gcgggcactc ccatgtgata gtgccaggcc agtccctggt      720

gagtacagcc ggccgacttt ggaggtgtcc cccaatgtgt gccacagcaa tatctattca      780

cccaaggaaa caatcccaga agaggcacga agtgatatgc actacagtgt ggctgagggc      840

ctcaaacctg ctgccccctc agcccgaaat gccccctact tcccttgtga caaggccagc      900

aaagaagaag agagaccctc ctcggaagat gagattgccc tgcatttcga gccccccaat      960

gcacccctga accggaaggg tctggttagt ccacagagcc cccagaaatc tgactgccag     1020

cccaactcgc ccacagagtc ctgcagcagt aagaatgcct gcatcctcca ggcttctggc     1080

tcccctccag ccaagagccc cactgacccc aaagcctgca actggaagaa atacaagttc     1140

atcgtgctca acagcctcaa ccagaatgcc aaaccagagg ggcctgagca ggctgagctg     1200

ggccgccttt ccccacgagc ctacacggcc ccacctgcct gccagccacc catggagcct     1260

gagaaccttg acctccagtc cccaaccaag ctgagtgcca gcggggagga ctccaccatc     1320

ccacaagcca gccggctcaa taacatcgtt aacaggtcca tgacgggctc tccccgcagc     1380

agcagcgaga gccactcacc actctacatg caccccccga agtgcacgtc ctgcggctct     1440

cagtccccac agcatgcaga gatgtgcctc cacaccgctg gccccacgtt ccctgaggag     1500

atgggagaga cccagtctga gtactcagat tctagctgtg agaacggggc cttcttctgc     1560

aatgagtgtg actgccgctt ctctgaggag gcctcactca agaggcacac gctgcagacc     1620

cacagtgaca aaccctacaa gtgtgaccgc tgccaggcct ccttccgcta caagggcaac     1680

ctcgccagcc acaagaccgt ccataccggt gagaaaccct atcgttgcaa catctgtggg     1740

gcccagttca accggccagc caacctgaaa acccacactc gaattcactc tggagagaag     1800

ccctacaaat gcgaaacctg cggagccaga tttgtacagg tggcccacct ccgtgcccat     1860

gtgcttatcc acactggtga gaagccctat ccctgtgaaa tctgtggcac ccgtttccgg     1920

caccttcaga ctctgaagag ccacctgcga atccacacag gagagaaacc ttaccattgt     1980

gagaagtgta acctgcattt ccgtcacaaa agccagctgc gacttcactt gcgccagaag     2040

catggcgcca tcaccaacac caaggtgcaa taccgcgtgt cagccactga cctgcctccg     2100

gagctcccca aagcctgcaa ggaaactgca gcagccaagt ttgagcggca gcacatggac     2160

tccagcactt ccgctgcctg a                                               2181


<210>  31
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  31

Met Ala Ser Pro Ala Asp Ser Cys Ile Gln Phe Thr Arg His Ala Ser 
1               5                   10                  15      


Asp Val Leu Leu Asn Leu Asn Arg Leu Arg Ser Arg Asp Ile Leu Thr 
            20                  25                  30          


Asp Val Val Ile Val Val Ser Arg Glu Gln Phe Arg Ala His Lys Thr 
        35                  40                  45              


Val Leu Met Ala Cys Ser Gly Leu Phe Tyr Ser Ile Phe Thr Asp Gln 
    50                  55                  60                  


Leu Lys Cys Asn Leu Ser Val Ile Asn Leu Asp Pro Glu Ile Asn Pro 
65                  70                  75                  80  


Glu Gly Phe Cys Ile Leu Leu Asp Phe Met Tyr Thr Ser Arg Leu Asn 
                85                  90                  95      


Leu Arg Glu Gly Asn Ile Met Ala Val Met Ala Thr Ala Met Tyr Leu 
            100                 105                 110         


Gln Met Glu His Val Val Asp Thr Cys Arg Lys Phe Ile Lys Ala Ser 
        115                 120                 125             


Glu Ala Glu Met Val Ser Ala Ile Lys Pro Pro Arg Glu Glu Phe Leu 
    130                 135                 140                 


Asn Ser Arg Met Leu Met Pro Gln Asp Ile Met Ala Tyr Arg Gly Arg 
145                 150                 155                 160 


Glu Val Val Glu Asn Asn Leu Pro Leu Arg Ser Ala Pro Gly Cys Glu 
                165                 170                 175     


Ser Arg Ala Phe Ala Pro Ser Leu Tyr Ser Gly Leu Ser Thr Pro Pro 
            180                 185                 190         


Ala Ser Tyr Ser Met Tyr Ser His Leu Pro Val Ser Ser Leu Leu Phe 
        195                 200                 205             


Ser Asp Glu Glu Phe Arg Asp Val Arg Met Pro Val Ala Asn Pro Phe 
    210                 215                 220                 


Pro Lys Glu Arg Ala Leu Pro Cys Asp Ser Ala Arg Pro Val Pro Gly 
225                 230                 235                 240 


Glu Tyr Ser Arg Pro Thr Leu Glu Val Ser Pro Asn Val Cys His Ser 
                245                 250                 255     


Asn Ile Tyr Ser Pro Lys Glu Thr Ile Pro Glu Glu Ala Arg Ser Asp 
            260                 265                 270         


Met His Tyr Ser Val Ala Glu Gly Leu Lys Pro Ala Ala Pro Ser Ala 
        275                 280                 285             


Arg Asn Ala Pro Tyr Phe Pro Cys Asp Lys Ala Ser Lys Glu Glu Glu 
    290                 295                 300                 


Arg Pro Ser Ser Glu Asp Glu Ile Ala Leu His Phe Glu Pro Pro Asn 
305                 310                 315                 320 


Ala Pro Leu Asn Arg Lys Gly Leu Val Ser Pro Gln Ser Pro Gln Lys 
                325                 330                 335     


Ser Asp Cys Gln Pro Asn Ser Pro Thr Glu Ser Cys Ser Ser Lys Asn 
            340                 345                 350         


Ala Cys Ile Leu Gln Ala Ser Gly Ser Pro Pro Ala Lys Ser Pro Thr 
        355                 360                 365             


Asp Pro Lys Ala Cys Asn Trp Lys Lys Tyr Lys Phe Ile Val Leu Asn 
    370                 375                 380                 


Ser Leu Asn Gln Asn Ala Lys Pro Glu Gly Pro Glu Gln Ala Glu Leu 
385                 390                 395                 400 


Gly Arg Leu Ser Pro Arg Ala Tyr Thr Ala Pro Pro Ala Cys Gln Pro 
                405                 410                 415     


Pro Met Glu Pro Glu Asn Leu Asp Leu Gln Ser Pro Thr Lys Leu Ser 
            420                 425                 430         


Ala Ser Gly Glu Asp Ser Thr Ile Pro Gln Ala Ser Arg Leu Asn Asn 
        435                 440                 445             


Ile Val Asn Arg Ser Met Thr Gly Ser Pro Arg Ser Ser Ser Glu Ser 
    450                 455                 460                 


His Ser Pro Leu Tyr Met His Pro Pro Lys Cys Thr Ser Cys Gly Ser 
465                 470                 475                 480 


Gln Ser Pro Gln His Ala Glu Met Cys Leu His Thr Ala Gly Pro Thr 
                485                 490                 495     


Phe Pro Glu Glu Met Gly Glu Thr Gln Ser Glu Tyr Ser Asp Ser Ser 
            500                 505                 510         


Cys Glu Asn Gly Ala Phe Phe Cys Asn Glu Cys Asp Cys Arg Phe Ser 
        515                 520                 525             


Glu Glu Ala Ser Leu Lys Arg His Thr Leu Gln Thr His Ser Asp Lys 
    530                 535                 540                 


Pro Tyr Lys Cys Asp Arg Cys Gln Ala Ser Phe Arg Tyr Lys Gly Asn 
545                 550                 555                 560 


Leu Ala Ser His Lys Thr Val His Thr Gly Glu Lys Pro Tyr Arg Cys 
                565                 570                 575     


Asn Ile Cys Gly Ala Gln Phe Asn Arg Pro Ala Asn Leu Lys Thr His 
            580                 585                 590         


Thr Arg Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Thr Cys Gly 
        595                 600                 605             


Ala Arg Phe Val Gln Val Ala His Leu Arg Ala His Val Leu Ile His 
    610                 615                 620                 


Thr Gly Glu Lys Pro Tyr Pro Cys Glu Ile Cys Gly Thr Arg Phe Arg 
625                 630                 635                 640 


His Leu Gln Thr Leu Lys Ser His Leu Arg Ile His Thr Gly Glu Lys 
                645                 650                 655     


Pro Tyr His Cys Glu Lys Cys Asn Leu His Phe Arg His Lys Ser Gln 
            660                 665                 670         


Leu Arg Leu His Leu Arg Gln Lys His Gly Ala Ile Thr Asn Thr Lys 
        675                 680                 685             


Val Gln Tyr Arg Val Ser Ala Thr Asp Leu Pro Pro Glu Leu Pro Lys 
    690                 695                 700                 


Ala Cys Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp 
705                 710                 715                 720 


Ser Ser Thr Ser Ala Ala 
                725     


<210>  32
<211>  3693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  32
atgcgaccct ccgggacggc cggggcagcg ctcctggcgc tgctggctgc gctctgcccg       60

gcgagtcggg ctctggagga aaagaaagtt tgccaaggca cgagtaacaa gctcacgcag      120

ttgggcactt ttgaagatca ttttctcagc ctccagagga tgttcaataa ctgtgaggtg      180

gtccttggga atttggaaat tacctatgtg cagaggaatt atgatctttc cttcttaaag      240

accatccagg aggtggctgg ttatgtcctc attgccctca acacagtgga gcgaattcct      300

ttggaaaacc tgcagatcat cagaggaaat atgtactacg aaaattccta tgccttagca      360

gtcttatcta actatgatgc aaataaaacc ggactgaagg agctgcccat gagaaattta      420

caggaaatcc tgcatggcgc cgtgcggttc agcaacaacc ctgccctgtg caacgtggag      480

agcatccagt ggcgggacat agtcagcagt gactttctca gcaacatgtc gatggacttc      540

cagaaccacc tgggcagctg ccaaaagtgt gatccaagct gtcccaatgg gagctgctgg      600

ggtgcaggag aggagaactg ccagaaactg accaaaatca tctgtgccca gcagtgctcc      660

gggcgctgcc gtggcaagtc ccccagtgac tgctgccaca accagtgtgc tgcaggctgc      720

acaggccccc gggagagcga ctgcctggtc tgccgcaaat tccgagacga agccacgtgc      780

aaggacacct gccccccact catgctctac aaccccacca cgtaccagat ggatgtgaac      840

cccgagggca aatacagctt tggtgccacc tgcgtgaaga agtgtccccg taattatgtg      900

gtgacagatc acggctcgtg cgtccgagcc tgtggggccg acagctatga gatggaggaa      960

gacggcgtcc gcaagtgtaa gaagtgcgaa gggccttgcc gcaaagtgtg taacggaata     1020

ggtattggtg aatttaaaga ctcactctcc ataaatgcta cgaatattaa acacttcaaa     1080

aactgcacct ccatcagtgg cgatctccac atcctgccgg tggcatttag gggtgactcc     1140

ttcacacata ctcctcctct ggatccacag gaactggata ttctgaaaac cgtaaaggaa     1200

atcacagggt ttttgctgat tcaggcttgg cctgaaaaca ggacggacct ccatgccttt     1260

gagaacctag aaatcatacg cggcaggacc aagcaacatg gtcagttttc tcttgcagtc     1320

gtcagcctga acataacatc cttgggatta cgctccctca aggagataag tgatggagat     1380

gtgataattt caggaaacaa aaatttgtgc tatgcaaata caataaactg gaaaaaactg     1440

tttgggacct ccggtcagaa aaccaaaatt ataagcaaca gaggtgaaaa cagctgcaag     1500

gccacaggcc aggtctgcca tgccttgtgc tcccccgagg gctgctgggg cccggagccc     1560

agggactgcg tctcttgccg gaatgtcagc cgaggcaggg aatgcgtgga caagtgcaac     1620

cttctggagg gtgagccaag ggagtttgtg gagaactctg agtgcataca gtgccaccca     1680

gagtgcctgc ctcaggccat gaacatcacc tgcacaggac ggggaccaga caactgtatc     1740

cagtgtgccc actacattga cggcccccac tgcgtcaaga cctgcccggc aggagtcatg     1800

ggagaaaaca acaccctggt ctggaagtac gcagacgccg gccatgtgtg ccacctgtgc     1860

catccaaact gcacctacgg atgcactggg ccaggtcttg aaggctgtcc aacgaatggg     1920

cctaagatcc cgtccatcgc cactgggatg gtgggggccc tcctcttgct gctggtggtg     1980

gccctgggga tcggcctctt catgcgaagg cgccacatcg ttcggaagcg cacgctgcgg     2040

aggctgctgc aggagaggga gcttgtggag cctcttacac ccagtggaga agctcccaac     2100

caagctctct tgaggatctt gaaggaaact gaattcaaaa agatcaaagt gctgggctcc     2160

ggtgcgttcg gcacggtgta taagggactc tggatcccag aaggtgagaa agttaaaatt     2220

cccgtcgcta tcaaggaatt aagagaagca acatctccga aagccaacaa ggaaatcctc     2280

gatgaagcct acgtgatggc cagcgtggac aacccccacg tgtgccgcct gctgggcatc     2340

tgcctcacct ccaccgtgca gctcatcatg cagctcatgc ccttcggctg cctcctggac     2400

tatgtccggg aacacaaaga caatattggc tcccagtacc tgctcaactg gtgtgtgcag     2460

atcgcaaagg gcatgaacta cttggaggac cgtcgcttgg tgcaccgcga cctggcagcc     2520

aggaacgtac tggtgaaaac accgcagcat gtcaagatca cagattttgg gcgggccaaa     2580

ctgctgggtg cggaagagaa agaataccat gcagaaggag gcaaagtgcc tatcaagtgg     2640

atggcattgg aatcaatttt acacagaatc tatacccacc agagtgatgt ctggagctac     2700

ggggtgactg tttgggagtt gatgaccttt ggatccaagc catatgacgg aatccctgcc     2760

agcgagatct cctccatcct ggagaaagga gaacgcctcc ctcagccacc catatgtacc     2820

atcgatgtct acatgatcat ggtcaagtgc tggatgatag acgcagatag tcgcccaaag     2880

ttccgtgagt tgatcatcga attctccaaa atggcccgag acccccagcg ctaccttgtc     2940

attcaggggg atgaaagaat gcatttgcca agtcctacag actccaactt ctaccgtgcc     3000

ctgatggatg aagaagacat ggacgacgtg gtggatgccg acgagtacct catcccacag     3060

cagggcttct tcagcagccc ctccacgtca cggactcccc tcctgagctc tctgagtgca     3120

accagcaaca attccaccgt ggcttgcatt gatagaaatg ggctgcaaag ctgtcccatc     3180

aaggaagaca gcttcttgca gcgatacagc tcagacccca caggcgcctt gactgaggac     3240

agcatagacg acaccttcct cccagtgcct gaatacataa accagtccgt tcccaaaagg     3300

cccgctggct ctgtgcagaa tcctgtctat cacaatcagc ctctgaaccc cgcgcccagc     3360

agagacccac actaccagga cccccacagc actgcagtgg gcaaccccga gtatctcaac     3420

actgtccagc ccacctgtgt caacagcaca ttcgacagcc ctgcccactg ggcccagaaa     3480

ggcagccacc aaattagcct ggacaaccct gactaccagc aggacttctt tcccaaggaa     3540

gccaagccaa atggcatctt taagggctcc acagctgaaa atgcagaata cctaagggtc     3600

gcgccacaaa gcagtgaatt tattggagca aaggaaactg cagcagccaa gtttgagcgg     3660

cagcacatgg actccagcac ttccgctgcc tga                                  3693


<210>  33
<211>  1230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  33

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Met Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Arg Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  Lys Glu Thr Ala Ala  Ala Lys Phe 
    1205                 1210                 1215             


Glu Arg  Gln His Met Asp Ser  Ser Thr Ser Ala Ala  
    1220                 1225                 1230 


<210>  34
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6xHis tag

<400>  34

His His His His His His 
1               5       


