                               SEQUENCE LISTING

<110> MEMORIAL SLOAN KETTERING CANCER CENTER

<120> ANTI-GPA33 MULTI-SPECIFIC ANTIBODIES AND USES THEREOF

<130> 115872-2363

<140> PCT/US2021/059634
<141> 2021-11-17

<150> 63/115,326
<151> 2020-11-18

<160> 116   

<170> PatentIn version 3.5

<210> 1
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210> 2
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210> 3
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210> 4
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
            100                 105         


<210> 5
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Val Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Phe Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
            100                 105         


<210> 6
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
            100                 105         


<210> 7
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
            100                 105         


<210> 8
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
            100                 105         


<210> 9
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Val Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
            100                 105         


<210> 10
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
            100                 105         


<210> 11
<211> 597
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        275                 280                 285             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
    290                 295                 300                 


Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr Ala Tyr Asn Thr 
                325                 330                 335     


Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
        355                 360                 365             


Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr Phe Asp Ala Trp 
    370                 375                 380                 


Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro 
            420                 425                 430         


Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
        435                 440                 445             


Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn Trp Val Gln Gln 
    450                 455                 460                 


Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly His Asn Asn Arg 
465                 470                 475                 480 


Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                485                 490                 495     


Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp Glu Ala Glu Tyr 
            500                 505                 510         


Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile Gly Gly Gly Thr 
        515                 520                 525             


Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr Thr His Thr Ser 
    530                 535                 540                 


Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg 
545                 550                 555                 560 


Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys 
                565                 570                 575     


Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His 
            580                 585                 590         


His His His His His 
        595         


<210> 12
<211> 1791
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
gaggtgcagc tggtggagag cggaggaggc ctggtgaagc caggaggcag cctgaggctg       60

tcctgcgccg cctctggatt cgcctttagc acctacgata tgtcctgggt gcgccaggca      120

cctggcaagg gcctggagtg ggtgtctacc atcagctccg gcggcagcta cacatactat      180

gccgactccg tgaagggccg gttcaccatc agccgggata acgccaagaa tagcctgtat      240

ctgcagatga actccctgcg ggccgaggac acagccgtgt actattgtgc cccaaccaca      300

gtggtgccct ttgcctattg gggccagggc accctggtga cagtgagcgc cggcggagga      360

ggctctggag gaggaggcag cggaggcggc ggctccggcg gcggcggctc tggcggcggc      420

ggcagcggag gaggcggctc cgacatccag atgacccaga gcccatctag cctgtccgcc      480

tctgtgggcg atcgggtgac catcacatgc aaggcctccc agaatgtgag aacagtggtg      540

gcctggtacc agcagaagcc cggcaaggcc cctaagaccc tgatctatct ggcctccaac      600

aggcacacag gagtgccatc tcgcttcagc ggctccggct ctggaaccga gtttaccctg      660

acaatctcca atctgcagcc tgaggatttc gccacatact attgtctgca gcactggtct      720

tacccactga cctttggcag cggcacaaag ctggaggtga agcggggcgg agggggatcc      780

ggcggcggag gatctggcgg aggtggaagt gggggaggcg gatctcatgt gcagctggtg      840

gaaagcggag gcggcctggt gcagcctggg ggatctctga gactgtcttg tgccgccagc      900

ggcttctccc tgaccgatta tggcgtgcac tgggtgcgac aggcccctgg caaaggactg      960

gaatggctgg gagtgatttg gagtggcgga ggcaccgcct acaacaccgc cctgatctcc     1020

cggttcacca tcagccggga caactccaag aacaccctgt acctgcagat gaactccctg     1080

cgggccgagg acaccgctgt gtactactgc gccagacggg gctcctaccc ctacaactac     1140

ttcgacgctt ggggctgcgg caccctcgtg acagtgtcta gcggaggggg aggttctggg     1200

ggcggaggtt caggtggtgg tggttccggg ggtggtggct ctggtggcgg tggttctggc     1260

ggtggcggat ctcaggctgt cgtgacccag gaacccagcc tgactgtgtc tcctggcgga     1320

accgtgaccc tgacctgcgg atcttctacc ggcgctgtga ccgccagcaa ctacgccaat     1380

tgggtgcagc agaaacctgg acagtgccct agaggcctga tcggcggcca caacaacaga     1440

cctccaggcg tgccagcccg gttctctgga tctctgctgg gcggaaaggc cgctctgaca     1500

ctgctgggtg ctcagcctga ggacgaggcc gagtactact gtgccctgtg gtactccgac     1560

cactgggtca tcggaggcgg gaccaagctg accgtgctgg gaacacccct gggagacacc     1620

acacatacta gtgggaaacc tctggatggc gagtacttta ccctgcagat tagaggccgc     1680

gaacgattcg agatgtttcg cgaactgaat gaggccctgg aactgaagga tgctcaggca     1740

ggcaaggagc caggagggtc aggaggagca ccgcaccatc atcatcacca t              1791


<210> 13
<211> 597
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr Asp Met Ser Trp Val Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly 
            180                 185                 190         


Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        195                 200                 205             


Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
    210                 215                 220                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Pro Thr Thr Val Val 
225                 230                 235                 240 


Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        275                 280                 285             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
    290                 295                 300                 


Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr Ala Tyr Asn Thr 
                325                 330                 335     


Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
        355                 360                 365             


Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr Phe Asp Ala Trp 
    370                 375                 380                 


Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro 
            420                 425                 430         


Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
        435                 440                 445             


Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn Trp Val Gln Gln 
    450                 455                 460                 


Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly His Asn Asn Arg 
465                 470                 475                 480 


Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                485                 490                 495     


Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp Glu Ala Glu Tyr 
            500                 505                 510         


Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile Gly Gly Gly Thr 
        515                 520                 525             


Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr Thr His Thr Ser 
    530                 535                 540                 


Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg 
545                 550                 555                 560 


Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys 
                565                 570                 575     


Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His 
            580                 585                 590         


His His His His His 
        595         


<210> 14
<211> 1791
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
gacatccaga tgacccagag cccaagctcc ctgtccgcct ctgtgggcga tagggtgacc       60

atcacatgca aggcctccca gaacgtgaga acagtggtgg cctggtacca gcagaagccc      120

ggcaaggccc ctaagaccct gatctatctg gcctccaaca ggcacacagg agtgccatct      180

cgcttcagcg gctccggctc tggaaccgag tttaccctga caatcagcaa tctgcagcct      240

gaggacttcg ccacatacta ttgtctgcag cactggtctt acccactgac ctttggcagc      300

ggcacaaagc tggaggtgaa gaggggagga ggaggcagcg gcggaggagg ctccggaggc      360

ggcggctctg gcggcggcgg cagcggcggc ggcggctccg gaggaggcgg ctctgaggtg      420

cagctggtgg agagcggagg aggcctggtg aagccaggag gcagcctgag gctgtcctgc      480

gccgcctctg gattcgcctt tagcacctac gacatgtcct gggtgcgcca ggcacctggc      540

aagggcctgg agtgggtgtc caccatctct agcggcggct cttacacata ctatgccgac      600

agcgtgaagg gccggttcac catctccaga gataacgcca agaattctct gtatctgcag      660

atgaatagcc tgcgggccga ggatacagcc gtgtactatt gtgccccaac cacagtggtg      720

ccctttgcct attggggcca gggcaccctg gtgacagtga gcgccggcgg agggggatcc      780

ggcggcggag gatctggcgg aggtggaagt gggggaggcg gatctcatgt gcagctggtg      840

gaaagcggag gcggcctggt gcagcctggg ggatctctga gactgtcttg tgccgccagc      900

ggcttctccc tgaccgatta tggcgtgcac tgggtgcgac aggcccctgg caaaggactg      960

gaatggctgg gagtgatttg gagtggcgga ggcaccgcct acaacaccgc cctgatctcc     1020

cggttcacca tcagccggga caactccaag aacaccctgt acctgcagat gaactccctg     1080

cgggccgagg acaccgctgt gtactactgc gccagacggg gctcctaccc ctacaactac     1140

ttcgacgctt ggggctgcgg caccctcgtg acagtgtcta gcggaggggg aggttctggg     1200

ggcggaggtt caggtggtgg tggttccggg ggtggtggct ctggtggcgg tggttctggc     1260

ggtggcggat ctcaggctgt cgtgacccag gaacccagcc tgactgtgtc tcctggcgga     1320

accgtgaccc tgacctgcgg atcttctacc ggcgctgtga ccgccagcaa ctacgccaat     1380

tgggtgcagc agaaacctgg acagtgccct agaggcctga tcggcggcca caacaacaga     1440

cctccaggcg tgccagcccg gttctctgga tctctgctgg gcggaaaggc cgctctgaca     1500

ctgctgggtg ctcagcctga ggacgaggcc gagtactact gtgccctgtg gtactccgac     1560

cactgggtca tcggaggcgg gaccaagctg accgtgctgg gaacacccct gggagacacc     1620

acacatacta gtgggaaacc tctggatggc gagtacttta ccctgcagat tagaggccgc     1680

gaacgattcg agatgtttcg cgaactgaat gaggccctgg aactgaagga tgctcaggca     1740

ggcaaggagc caggagggtc aggaggagca ccgcaccatc atcatcacca t              1791


<210> 15
<211> 597
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        275                 280                 285             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
    290                 295                 300                 


Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr Ala Tyr Asn Thr 
                325                 330                 335     


Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
        355                 360                 365             


Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr Phe Asp Ala Trp 
    370                 375                 380                 


Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro 
            420                 425                 430         


Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
        435                 440                 445             


Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn Trp Val Gln Gln 
    450                 455                 460                 


Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly His Asn Asn Arg 
465                 470                 475                 480 


Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                485                 490                 495     


Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp Glu Ala Glu Tyr 
            500                 505                 510         


Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile Gly Gly Gly Thr 
        515                 520                 525             


Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr Thr His Thr Ser 
    530                 535                 540                 


Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg 
545                 550                 555                 560 


Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys 
                565                 570                 575     


Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His 
            580                 585                 590         


His His His His His 
        595         


<210> 16
<211> 1791
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
gaggtgcagc tggtggagtc tggtgggggt ctggtcgatc ctggtggtag tctgaggctg       60

agttgtgccg cttctgggtt tgccttcagc acctacgaca tgtcctgggt gagacaggct      120

ccaggcaagg gcctggagtg ggtgtctacc atcagctccg gcggcagcta cacatactat      180

gctgactccg tgaagggccg gttcaccatc tctagggata acgccgctaa tagcctgtat      240

ctgcagatga actccctgcg cgccgaggat acagccgtgt actattgcgc cccaaccaca      300

gtggtgccct ttgcttattg gggccagggc accctggtga cagtgtccgc cggcggagga      360

ggctctggag gaggaggcag cggtggcggc ggctccggcg gcggcggctc tggcggcggc      420

ggcagcggtg gtggcggctc cgacatccag atgacccagt ccccttctag cctgtccgct      480

tctgtgggcg atcgggtgac catcacatgc aaggcctctc agaatgtgag gacagtggtg      540

gcttggtacc agcagaagcc cggcaaggcc cctaagaccc tgatctatct ggcttctaac      600

agacacacag gagtgcctag ccgcttcagc ggctccggct ctggaaccga gtttaccctg      660

acaatcagca atctgcagcc agaggacttc gccacatact attgtctgca gcactggtct      720

taccccctga cttttgggag cgggactaaa ctggaggtga aacggggcgg agggggatcc      780

ggcggcggag gatctggcgg aggtggaagt gggggaggcg gatctcatgt gcagctggtg      840

gaaagcggag gcggcctggt gcagcctggg ggatctctga gactgtcttg tgccgccagc      900

ggcttctccc tgaccgatta tggcgtgcac tgggtgcgac aggcccctgg caaaggactg      960

gaatggctgg gagtgatttg gagtggcgga ggcaccgcct acaacaccgc cctgatctcc     1020

cggttcacca tcagccggga caactccaag aacaccctgt acctgcagat gaactccctg     1080

cgggccgagg acaccgctgt gtactactgc gccagacggg gctcctaccc ctacaactac     1140

ttcgacgctt ggggctgcgg caccctcgtg acagtgtcta gcggaggggg aggttctggg     1200

ggcggaggtt caggtggtgg tggttccggg ggtggtggct ctggtggcgg tggttctggc     1260

ggtggcggat ctcaggctgt cgtgacccag gaacccagcc tgactgtgtc tcctggcgga     1320

accgtgaccc tgacctgcgg atcttctacc ggcgctgtga ccgccagcaa ctacgccaat     1380

tgggtgcagc agaaacctgg acagtgccct agaggcctga tcggcggcca caacaacaga     1440

cctccaggcg tgccagcccg gttctctgga tctctgctgg gcggaaaggc cgctctgaca     1500

ctgctgggtg ctcagcctga ggacgaggcc gagtactact gtgccctgtg gtactccgac     1560

cactgggtca tcggaggcgg gaccaagctg accgtgctgg gaacacccct gggagacacc     1620

acacatacta gtgggaaacc tctggatggc gagtacttta ccctgcagat tagaggccgc     1680

gaacgattcg agatgtttcg cgaactgaat gaggccctgg aactgaagga tgctcaggca     1740

ggcaaggagc caggagggtc aggaggagca ccgcaccatc atcatcacca t              1791


<210> 17
<211> 597
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        275                 280                 285             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
    290                 295                 300                 


Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr Ala Tyr Asn Thr 
                325                 330                 335     


Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
        355                 360                 365             


Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr Phe Asp Ala Trp 
    370                 375                 380                 


Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro 
            420                 425                 430         


Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
        435                 440                 445             


Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn Trp Val Gln Gln 
    450                 455                 460                 


Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly His Asn Asn Arg 
465                 470                 475                 480 


Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                485                 490                 495     


Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp Glu Ala Glu Tyr 
            500                 505                 510         


Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile Gly Gly Gly Thr 
        515                 520                 525             


Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr Thr His Thr Ser 
    530                 535                 540                 


Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg 
545                 550                 555                 560 


Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys 
                565                 570                 575     


Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His 
            580                 585                 590         


His His His His His 
        595         


<210> 18
<211> 1791
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 18
gaggtgcagc tggtggagag cggaggaggc ctggtggacc ccggaggcag cctgagactg       60

tcctgcgccg cttctggctt cgcctttagc acctacgata tgtcctgggt gcgccaggct      120

cctggcaagg gcctggagtg ggtgtctacc atcagctccg gcggcagcta cacatactat      180

gccgactccg tgaagggccg gttcaccatc tctagggata acgctaagaa tagcctgtat      240

ctgcagatga actccctgcg ggccgaggac acagccgtgt actattgtgc cccaaccaca      300

gtggtgccct ttgcttattg gggccagggc accctggtga cagtgtctgc cggcggagga      360

ggctctggag gaggaggcag cggtggcggc ggctccggcg gcggcggctc tggcggcggc      420

ggcagcggtg gtggcggctc cgacatccag atgacccaga gcccatctag cctgtccgct      480

tctgtgggcg atcgggtgac catcacatgc aaggcctccc agaatgtgag gacagtggtg      540

gcttggtacc agcagaagcc cggcaaggcc cctaagaccc tgatctatct ggcttccaac      600

agacacacag gagtgccctc tcgcttcagc ggctccggct ctggaaccga gtttaccctg      660

acaatctcca atctgcagcc tgaggatttc gccacatact attgtctgca gcactggtct      720

tacccactga cctttggcag cggcacaaag ctggaggtga agcggggcgg agggggatcc      780

ggcggcggag gatctggcgg aggtggaagt gggggaggcg gatctcatgt gcagctggtg      840

gaaagcggag gcggcctggt gcagcctggg ggatctctga gactgtcttg tgccgccagc      900

ggcttctccc tgaccgatta tggcgtgcac tgggtgcgac aggcccctgg caaaggactg      960

gaatggctgg gagtgatttg gagtggcgga ggcaccgcct acaacaccgc cctgatctcc     1020

cggttcacca tcagccggga caactccaag aacaccctgt acctgcagat gaactccctg     1080

cgggccgagg acaccgctgt gtactactgc gccagacggg gctcctaccc ctacaactac     1140

ttcgacgctt ggggctgcgg caccctcgtg acagtgtcta gcggaggggg aggttctggg     1200

ggcggaggtt caggtggtgg tggttccggg ggtggtggct ctggtggcgg tggttctggc     1260

ggtggcggat ctcaggctgt cgtgacccag gaacccagcc tgactgtgtc tcctggcgga     1320

accgtgaccc tgacctgcgg atcttctacc ggcgctgtga ccgccagcaa ctacgccaat     1380

tgggtgcagc agaaacctgg acagtgccct agaggcctga tcggcggcca caacaacaga     1440

cctccaggcg tgccagcccg gttctctgga tctctgctgg gcggaaaggc cgctctgaca     1500

ctgctgggtg ctcagcctga ggacgaggcc gagtactact gtgccctgtg gtactccgac     1560

cactgggtca tcggaggcgg gaccaagctg accgtgctgg gaacacccct gggagacacc     1620

acacatacta gtgggaaacc tctggatggc gagtacttta ccctgcagat tagaggccgc     1680

gaacgattcg agatgtttcg cgaactgaat gaggccctgg aactgaagga tgctcaggca     1740

ggcaaggagc caggagggtc aggaggagca ccgcaccatc atcatcacca t              1791


<210> 19
<211> 597
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        275                 280                 285             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
    290                 295                 300                 


Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr Ala Tyr Asn Thr 
                325                 330                 335     


Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
        355                 360                 365             


Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr Phe Asp Ala Trp 
    370                 375                 380                 


Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro 
            420                 425                 430         


Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
        435                 440                 445             


Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn Trp Val Gln Gln 
    450                 455                 460                 


Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly His Asn Asn Arg 
465                 470                 475                 480 


Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                485                 490                 495     


Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp Glu Ala Glu Tyr 
            500                 505                 510         


Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile Gly Gly Gly Thr 
        515                 520                 525             


Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr Thr His Thr Ser 
    530                 535                 540                 


Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg 
545                 550                 555                 560 


Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys 
                565                 570                 575     


Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His 
            580                 585                 590         


His His His His His 
        595         


<210> 20
<211> 1790
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 20
gaggtgcagc tggtggagag cggaggaggc ctggtggacc ccggaggcag cctgagactg       60

tcctgcgccg cttctggctt cgcctttagc acctacgata tgtcctgggt gcgccaggct      120

cctggcaagg gcctggagtg ggtgtctacc atcagctccg gcggcagcta cacatactat      180

gccgactccg tgaagggccg gttcaccatc tctagggata acgccgctaa tagcctgtat      240

ctgcagatga actccctgcg ggccgaggac acagccgtgt actattgtgc cccaaccaca      300

gtggtgccct ttgcttattg gggccagggc accctggtga cagtgtctgc cggcggagga      360

ggctctggag gaggaggcag cggtggcggc ggctccggcg gcggcggctc tggcggcggc      420

ggcagcggtg gtggcggctc cgacatccag atgacccaga gcccatctag cctgtccgct      480

tctgtgggcg atcgggtgac catcacatgc aaggcctccc agaatgtgag gacagtggtg      540

gcttggtacc agcagaagcc cggccaggcc cctaagaccc tgatctatct ggcttccaac      600

agacacacag gagtgccctc tcgcttcagc ggctccggct ctggaaccga gtttaccctg      660

acaatctcca atctgcagcc tgaggatttc gccacatact attgtctgca gcactggtct      720

tacccactga cctttggcag cggcacaaag ctggaggtga agcgggcgga gggggatccg      780

gcggcggagg atctggcgga ggtggaagtg ggggaggcgg atctcatgtg cagctggtgg      840

aaagcggagg cggcctggtg cagcctgggg gatctctgag actgtcttgt gccgccagcg      900

gcttctccct gaccgattat ggcgtgcact gggtgcgaca ggcccctggc aaaggactgg      960

aatggctggg agtgatttgg agtggcggag gcaccgccta caacaccgcc ctgatctccc     1020

ggttcaccat cagccgggac aactccaaga acaccctgta cctgcagatg aactccctgc     1080

gggccgagga caccgctgtg tactactgcg ccagacgggg ctcctacccc tacaactact     1140

tcgacgcttg gggctgcggc accctcgtga cagtgtctag cggaggggga ggttctgggg     1200

gcggaggttc aggtggtggt ggttccgggg gtggtggctc tggtggcggt ggttctggcg     1260

gtggcggatc tcaggctgtc gtgacccagg aacccagcct gactgtgtct cctggcggaa     1320

ccgtgaccct gacctgcgga tcttctaccg gcgctgtgac cgccagcaac tacgccaatt     1380

gggtgcagca gaaacctgga cagtgcccta gaggcctgat cggcggccac aacaacagac     1440

ctccaggcgt gccagcccgg ttctctggat ctctgctggg cggaaaggcc gctctgacac     1500

tgctgggtgc tcagcctgag gacgaggccg agtactactg tgccctgtgg tactccgacc     1560

actgggtcat cggaggcggg accaagctga ccgtgctggg aacacccctg ggagacacca     1620

cacatactag tgggaaacct ctggatggcg agtactttac cctgcagatt agaggccgcg     1680

aacgattcga gatgtttcgc gaactgaatg aggccctgga actgaaggat gctcaggcag     1740

gcaaggagcc aggagggtca ggaggagcac cgcaccatca tcatcaccat                1790


<210> 21
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Lys Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly 
225                 230                 235                 240 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                245                 250                 255     


Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala 
            260                 265                 270         


Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly 
        275                 280                 285             


Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp 
    290                 295                 300                 


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
305                 310                 315                 320 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn 
                325                 330                 335     


Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val 
    370                 375                 380                 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
385                 390                 395                 400 


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala 
                405                 410                 415     


Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly 
            420                 425                 430         


Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser 
        435                 440                 445             


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu 
    450                 455                 460                 


Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val 
465                 470                 475                 480 


Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                485                 490     


<210> 22
<211> 1470
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 22
gacatccaga tgacccagag cccatctagc ctgtccgcct ctgtgggcga tcgggtgacc       60

atcacatgca aggcctccca gaatgtgaga acagtggtgg cctggtacca gcagaagccc      120

ggcaaggccc ctaagaccct gatctatctg gcctccaaca ggcacacagg agtgccatct      180

cgcttcagcg gctccggctc tggaaccgag tttaccctga caatctccaa tctgcagcct      240

gaggatttcg ccacatacta ttgtctgcag cactggtctt acccactgac ctttggcagc      300

ggcacaaagc tggaggtgaa gagaaccgtg gccgctccct ccgtgttcat cttcccacct      360

tccgacgagc agctgaagtc cggcaccgct tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctaca gcctgtcctc taccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gcactagtgg cggcggagga      660

tctggcggag gtggaagtgg gggaggcgga tctcatgtgc agctggtgga aagcggaggc      720

ggcctggtgc agcctggggg atctctgaga ctgtcttgtg ccgccagcgg cttctccctg      780

accgattatg gcgtgcactg ggtgcgacag gcccctggca aaggactgga atggctggga      840

gtgatttgga gtggcggagg caccgcctac aacaccgccc tgatctcccg gttcaccatc      900

agccgggaca actccaagaa caccctgtac ctgcagatga actccctgcg ggccgaggac      960

accgctgtgt actactgcgc cagacggggc tcctacccct acaactactt cgacgcttgg     1020

ggctgcggca ccctcgtgac agtgtctagc ggagggggag gttctggggg cggaggttca     1080

ggtggtggtg gttccggggg tggtggctct ggtggcggtg gttctggcgg tggcggatct     1140

caggctgtcg tgacccagga acccagcctg actgtgtctc ctggcggaac cgtgaccctg     1200

acctgcggat cttctaccgg cgctgtgacc gccagcaact acgccaattg ggtgcagcag     1260

aaacctggac agtgccctag aggcctgatc ggcggccaca acaacagacc tccaggcgtg     1320

ccagcccggt tctctggatc tctgctgggc ggaaaggccg ctctgacact gctgggtgct     1380

cagcctgagg acgaggccga gtactactgt gccctgtggt actccgacca ctgggtcatc     1440

ggaggcggga ccaagctgac cgtgctggga                                      1470


<210> 23
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210> 24
<211> 1341
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 24
gaggtgcagc tggtggaatc tggcggcgga ctcgtgaagc ctggcggctc tctgagactg       60

tcttgtgccg cctctggctt cgccttctcc acctacgaca tgtcctgggt gcgacaggcc      120

cctggcaaga gactggaatg ggtggccaca atctcctccg gcggctccta cacctactac      180

ctggactctg tgaagggccg gttcaccatc tcccgggaca acgccaagaa ctccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actattgtgc tcccaccacc      300

gtggtgccct tcgcctattg gggacagggc accctcgtga ccgtgtcctc tgcttctacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggccgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210> 25
<211> 490
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
225                 230                 235                 240 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                245                 250                 255     


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
            260                 265                 270         


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
        275                 280                 285             


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
    290                 295                 300                 


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
305                 310                 315                 320 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
                325                 330                 335     


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
    370                 375                 380                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
385                 390                 395                 400 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
                405                 410                 415     


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
            420                 425                 430         


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
        435                 440                 445             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
    450                 455                 460                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
465                 470                 475                 480 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                485                 490 


<210> 26
<211> 1470
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 26
gacatccaga tgacccagag ccctagctcc ctgtctacaa gcgtgggcga tagggtgacc       60

atcacatgca aggcctccca gaacgtgaga accgtggtgg cctggtacca gcagaagccc      120

ggcaaggccc ctaagacact gatctatctg gcctccaaca ggcactctgg agtgcccagc      180

agattctccg gctctggcag cggcaccgag tttaccctga caatctctaa tctgcagcca      240

gaggacttcg ccacatacta ttgtctgcag cactggtcct accccctgac ctttggctct      300

ggcacaaagc tggaggtgaa gagaaccgtg gccgctccct ccgtgttcat cttcccacct      360

tccgacgagc agctgaagtc cggcaccgct tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctaca gcctgtcctc taccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gcactagtgg cggcggagga      660

tctggcggag gtggaagtgg gggaggcgga tctcatgtgc agctggtgga aagcggaggc      720

ggcctggtgc agcctggggg atctctgaga ctgtcttgtg ccgccagcgg cttctccctg      780

accgattatg gcgtgcactg ggtgcgacag gcccctggca aaggactgga atggctggga      840

gtgatttgga gtggcggagg caccgcctac aacaccgccc tgatctcccg gttcaccatc      900

agccgggaca actccaagaa caccctgtac ctgcagatga actccctgcg ggccgaggac      960

accgctgtgt actactgcgc cagacggggc tcctacccct acaactactt cgacgcttgg     1020

ggctgcggca ccctcgtgac agtgtctagc ggagggggag gttctggggg cggaggttca     1080

ggtggtggtg gttccggggg tggtggctct ggtggcggtg gttctggcgg tggcggatct     1140

caggctgtcg tgacccagga acccagcctg actgtgtctc ctggcggaac cgtgaccctg     1200

acctgcggat cttctaccgg cgctgtgacc gccagcaact acgccaattg ggtgcagcag     1260

aaacctggac agtgccctag aggcctgatc ggcggccaca acaacagacc tccaggcgtg     1320

ccagcccggt tctctggatc tctgctgggc ggaaaggccg ctctgacact gctgggtgct     1380

cagcctgagg acgaggccga gtactactgt gccctgtggt actccgacca ctgggtcatc     1440

ggaggcggga ccaagctgac cgtgctggga                                      1470


<210> 27
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210> 28
<211> 1341
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 28
gaggtgcagc tggtggagtc cggaggaggc ctggtgaagc caggaggctc cctgaggctg       60

tcttgcgccg ccagcggatt cgccttttcc acctacgaca tgtcttgggt gcgccaggca      120

ccaggcaagg gcctggagtg ggtggcaacc atcagctccg gaggcagcta cacatactat      180

gccgactccg tgaagggccg gttcaccatc agccgggaca gcgccaagaa ctctctgtat      240

ctgcagatga atagcctgcg ggccgaggat acagccgtgt actattgtgc ccccaccaca      300

gtggtgcctt ttgcctattg gggccagggc accctggtga cagtgtctgc cgcttctacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggccgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210> 29
<211> 594
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln 
        275                 280                 285             


Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    290                 295                 300                 


Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 
305                 310                 315                 320 


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                325                 330                 335     


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
            340                 345                 350         


Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val 
        355                 360                 365             


Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
            420                 425                 430         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser 
        435                 440                 445             


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly 
    450                 455                 460                 


Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
465                 470                 475                 480 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe 
                485                 490                 495     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
            500                 505                 510         


Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Cys Gly Thr Lys Leu Gln 
        515                 520                 525             


Ile Thr Arg Thr Pro Leu Gly Asp Thr Thr His Thr Ser Gly Lys Pro 
    530                 535                 540                 


Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe 
545                 550                 555                 560 


Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln 
                565                 570                 575     


Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His His His His 
            580                 585                 590         


His His 
        


<210> 30
<211> 594
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln 
        275                 280                 285             


Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    290                 295                 300                 


Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 
305                 310                 315                 320 


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                325                 330                 335     


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
            340                 345                 350         


Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val 
        355                 360                 365             


Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
            420                 425                 430         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser 
        435                 440                 445             


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly 
    450                 455                 460                 


Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
465                 470                 475                 480 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe 
                485                 490                 495     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
            500                 505                 510         


Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Cys Gly Thr Lys Leu Gln 
        515                 520                 525             


Ile Thr Arg Thr Pro Leu Gly Asp Thr Thr His Thr Ser Gly Lys Pro 
    530                 535                 540                 


Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe 
545                 550                 555                 560 


Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln 
                565                 570                 575     


Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His His His His 
            580                 585                 590         


His His 
        


<210> 31
<211> 594
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln 
        275                 280                 285             


Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    290                 295                 300                 


Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 
305                 310                 315                 320 


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                325                 330                 335     


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
            340                 345                 350         


Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val 
        355                 360                 365             


Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
            420                 425                 430         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser 
        435                 440                 445             


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly 
    450                 455                 460                 


Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
465                 470                 475                 480 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe 
                485                 490                 495     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
            500                 505                 510         


Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Cys Gly Thr Lys Leu Gln 
        515                 520                 525             


Ile Thr Arg Thr Pro Leu Gly Asp Thr Thr His Thr Ser Gly Lys Pro 
    530                 535                 540                 


Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe 
545                 550                 555                 560 


Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln 
                565                 570                 575     


Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His His His His 
            580                 585                 590         


His His 
        


<210> 32
<211> 594
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln 
        275                 280                 285             


Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    290                 295                 300                 


Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 
305                 310                 315                 320 


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                325                 330                 335     


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
            340                 345                 350         


Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val 
        355                 360                 365             


Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
            420                 425                 430         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser 
        435                 440                 445             


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly 
    450                 455                 460                 


Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
465                 470                 475                 480 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe 
                485                 490                 495     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
            500                 505                 510         


Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Cys Gly Thr Lys Leu Gln 
        515                 520                 525             


Ile Thr Arg Thr Pro Leu Gly Asp Thr Thr His Thr Ser Gly Lys Pro 
    530                 535                 540                 


Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe 
545                 550                 555                 560 


Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln 
                565                 570                 575     


Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His His His His 
            580                 585                 590         


His His 
        


<210> 33
<211> 594
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Ala Lys 
        275                 280                 285             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    290                 295                 300                 


Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                325                 330                 335     


Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Arg Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
            420                 425                 430         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser 
        435                 440                 445             


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly 
    450                 455                 460                 


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
465                 470                 475                 480 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                485                 490                 495     


Thr Ile Ser Ser Met Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            500                 505                 510         


Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        515                 520                 525             


Ile Asn Arg Thr Pro Leu Gly Asp Thr Thr His Thr Ser Gly Lys Pro 
    530                 535                 540                 


Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe 
545                 550                 555                 560 


Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln 
                565                 570                 575     


Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His His His His 
            580                 585                 590         


His His 
        


<210> 34
<211> 594
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Ala Lys 
        275                 280                 285             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    290                 295                 300                 


Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                325                 330                 335     


Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Arg Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
            420                 425                 430         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser 
        435                 440                 445             


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly 
    450                 455                 460                 


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
465                 470                 475                 480 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                485                 490                 495     


Thr Ile Ser Ser Met Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            500                 505                 510         


Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        515                 520                 525             


Ile Asn Arg Thr Pro Leu Gly Asp Thr Thr His Thr Ser Gly Lys Pro 
    530                 535                 540                 


Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe 
545                 550                 555                 560 


Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln 
                565                 570                 575     


Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His His His His 
            580                 585                 590         


His His 
        


<210> 35
<211> 594
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Ala Lys 
        275                 280                 285             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    290                 295                 300                 


Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                325                 330                 335     


Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Arg Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
            420                 425                 430         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser 
        435                 440                 445             


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly 
    450                 455                 460                 


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
465                 470                 475                 480 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                485                 490                 495     


Thr Ile Ser Ser Met Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            500                 505                 510         


Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        515                 520                 525             


Ile Asn Arg Thr Pro Leu Gly Asp Thr Thr His Thr Ser Gly Lys Pro 
    530                 535                 540                 


Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe 
545                 550                 555                 560 


Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln 
                565                 570                 575     


Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His His His His 
            580                 585                 590         


His His 
        


<210> 36
<211> 594
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Ala Lys 
        275                 280                 285             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    290                 295                 300                 


Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                325                 330                 335     


Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Arg Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
            420                 425                 430         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser 
        435                 440                 445             


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly 
    450                 455                 460                 


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
465                 470                 475                 480 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                485                 490                 495     


Thr Ile Ser Ser Met Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            500                 505                 510         


Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        515                 520                 525             


Ile Asn Arg Thr Pro Leu Gly Asp Thr Thr His Thr Ser Gly Lys Pro 
    530                 535                 540                 


Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe 
545                 550                 555                 560 


Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln 
                565                 570                 575     


Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His His His His 
            580                 585                 590         


His His 
        


<210> 37
<211> 594
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Ala Lys 
        275                 280                 285             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    290                 295                 300                 


Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                325                 330                 335     


Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Arg Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
            420                 425                 430         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser 
        435                 440                 445             


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly 
    450                 455                 460                 


Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
465                 470                 475                 480 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                485                 490                 495     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            500                 505                 510         


Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        515                 520                 525             


Ile Asn Arg Thr Pro Leu Gly Asp Thr Thr His Thr Ser Gly Lys Pro 
    530                 535                 540                 


Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe 
545                 550                 555                 560 


Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln 
                565                 570                 575     


Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His His His His 
            580                 585                 590         


His His 
        


<210> 38
<211> 594
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Ala Lys 
        275                 280                 285             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    290                 295                 300                 


Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                325                 330                 335     


Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Arg Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
            420                 425                 430         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser 
        435                 440                 445             


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly 
    450                 455                 460                 


Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
465                 470                 475                 480 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                485                 490                 495     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            500                 505                 510         


Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        515                 520                 525             


Ile Asn Arg Thr Pro Leu Gly Asp Thr Thr His Thr Ser Gly Lys Pro 
    530                 535                 540                 


Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe 
545                 550                 555                 560 


Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln 
                565                 570                 575     


Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His His His His 
            580                 585                 590         


His His 
        


<210> 39
<211> 594
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Ala Lys 
        275                 280                 285             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    290                 295                 300                 


Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                325                 330                 335     


Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Arg Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
            420                 425                 430         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser 
        435                 440                 445             


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly 
    450                 455                 460                 


Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
465                 470                 475                 480 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                485                 490                 495     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            500                 505                 510         


Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        515                 520                 525             


Ile Asn Arg Thr Pro Leu Gly Asp Thr Thr His Thr Ser Gly Lys Pro 
    530                 535                 540                 


Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe 
545                 550                 555                 560 


Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln 
                565                 570                 575     


Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His His His His 
            580                 585                 590         


His His 
        


<210> 40
<211> 594
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Ala Lys 
        275                 280                 285             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    290                 295                 300                 


Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                325                 330                 335     


Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Arg Asp Lys Ser Ile Ser 
            340                 345                 350         


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
            420                 425                 430         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser 
        435                 440                 445             


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly 
    450                 455                 460                 


Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
465                 470                 475                 480 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                485                 490                 495     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            500                 505                 510         


Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        515                 520                 525             


Ile Asn Arg Thr Pro Leu Gly Asp Thr Thr His Thr Ser Gly Lys Pro 
    530                 535                 540                 


Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe 
545                 550                 555                 560 


Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln 
                565                 570                 575     


Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His His His His 
            580                 585                 590         


His His 
        


<210> 41
<211> 875
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        275                 280                 285             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
    290                 295                 300                 


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
                325                 330                 335     


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            340                 345                 350         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
        355                 360                 365             


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                405                 410                 415     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            420                 425                 430         


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
        435                 440                 445             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    450                 455                 460                 


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
465                 470                 475                 480 


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                485                 490                 495     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
            500                 505                 510         


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
        515                 520                 525             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
545                 550                 555                 560 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                565                 570                 575     


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
            580                 585                 590         


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
        595                 600                 605             


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
    610                 615                 620                 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
625                 630                 635                 640 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
                645                 650                 655     


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
    690                 695                 700                 


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
705                 710                 715                 720 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
                725                 730                 735     


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
            740                 745                 750         


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
        755                 760                 765             


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
    770                 775                 780                 


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
785                 790                 795                 800 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
                805                 810                 815     


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
            820                 825                 830         


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
        835                 840                 845             


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
    850                 855                 860                 


Ser Gly Gly Ala Pro His His His His His His 
865                 870                 875 


<210> 42
<211> 875
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        275                 280                 285             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
    290                 295                 300                 


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
                325                 330                 335     


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            340                 345                 350         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
        355                 360                 365             


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                405                 410                 415     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            420                 425                 430         


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
        435                 440                 445             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    450                 455                 460                 


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
465                 470                 475                 480 


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                485                 490                 495     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
            500                 505                 510         


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
        515                 520                 525             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
545                 550                 555                 560 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                565                 570                 575     


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
            580                 585                 590         


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
        595                 600                 605             


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
    610                 615                 620                 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
625                 630                 635                 640 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
                645                 650                 655     


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
    690                 695                 700                 


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
705                 710                 715                 720 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
                725                 730                 735     


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
            740                 745                 750         


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
        755                 760                 765             


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
    770                 775                 780                 


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
785                 790                 795                 800 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
                805                 810                 815     


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
            820                 825                 830         


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
        835                 840                 845             


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
    850                 855                 860                 


Ser Gly Gly Ala Pro His His His His His His 
865                 870                 875 


<210> 43
<211> 875
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        275                 280                 285             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
    290                 295                 300                 


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
                325                 330                 335     


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            340                 345                 350         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
        355                 360                 365             


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                405                 410                 415     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            420                 425                 430         


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
        435                 440                 445             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    450                 455                 460                 


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
465                 470                 475                 480 


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                485                 490                 495     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
            500                 505                 510         


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
        515                 520                 525             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
545                 550                 555                 560 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                565                 570                 575     


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
            580                 585                 590         


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
        595                 600                 605             


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
    610                 615                 620                 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
625                 630                 635                 640 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
                645                 650                 655     


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
    690                 695                 700                 


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
705                 710                 715                 720 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
                725                 730                 735     


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
            740                 745                 750         


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
        755                 760                 765             


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
    770                 775                 780                 


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
785                 790                 795                 800 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
                805                 810                 815     


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
            820                 825                 830         


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
        835                 840                 845             


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
    850                 855                 860                 


Ser Gly Gly Ala Pro His His His His His His 
865                 870                 875 


<210> 44
<211> 875
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        275                 280                 285             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
    290                 295                 300                 


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
                325                 330                 335     


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            340                 345                 350         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
        355                 360                 365             


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                405                 410                 415     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            420                 425                 430         


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
        435                 440                 445             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    450                 455                 460                 


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
465                 470                 475                 480 


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                485                 490                 495     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
            500                 505                 510         


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
        515                 520                 525             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
545                 550                 555                 560 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                565                 570                 575     


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
            580                 585                 590         


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
        595                 600                 605             


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
    610                 615                 620                 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
625                 630                 635                 640 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
                645                 650                 655     


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
    690                 695                 700                 


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
705                 710                 715                 720 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
                725                 730                 735     


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
            740                 745                 750         


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
        755                 760                 765             


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
    770                 775                 780                 


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
785                 790                 795                 800 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
                805                 810                 815     


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
            820                 825                 830         


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
        835                 840                 845             


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
    850                 855                 860                 


Ser Gly Gly Ala Pro His His His His His His 
865                 870                 875 


<210> 45
<211> 872
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        275                 280                 285             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
    290                 295                 300                 


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
                325                 330                 335     


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            340                 345                 350         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
        355                 360                 365             


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                405                 410                 415     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            420                 425                 430         


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
        435                 440                 445             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    450                 455                 460                 


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
465                 470                 475                 480 


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                485                 490                 495     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
            500                 505                 510         


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
        515                 520                 525             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
545                 550                 555                 560 


Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys 
                565                 570                 575     


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln 
            580                 585                 590         


Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
        595                 600                 605             


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser 
    610                 615                 620                 


Arg Asp Asn Ser Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg 
625                 630                 635                 640 


Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His 
                645                 650                 655     


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    690                 695                 700                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
705                 710                 715                 720 


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
                725                 730                 735     


Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr 
            740                 745                 750         


Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        755                 760                 765             


Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile 
    770                 775                 780                 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
785                 790                 795                 800 


Cys Gly Thr Lys Leu Gln Ile Thr Arg Thr Pro Leu Gly Asp Thr Thr 
                805                 810                 815     


His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile 
            820                 825                 830         


Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu 
        835                 840                 845             


Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly 
    850                 855                 860                 


Ala Pro His His His His His His 
865                 870         


<210> 46
<211> 872
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        275                 280                 285             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
    290                 295                 300                 


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
                325                 330                 335     


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            340                 345                 350         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
        355                 360                 365             


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                405                 410                 415     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            420                 425                 430         


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
        435                 440                 445             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    450                 455                 460                 


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
465                 470                 475                 480 


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                485                 490                 495     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
            500                 505                 510         


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
        515                 520                 525             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
545                 550                 555                 560 


Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys 
                565                 570                 575     


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln 
            580                 585                 590         


Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
        595                 600                 605             


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser 
    610                 615                 620                 


Arg Asp Asn Ser Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg 
625                 630                 635                 640 


Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His 
                645                 650                 655     


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    690                 695                 700                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
705                 710                 715                 720 


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
                725                 730                 735     


Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr 
            740                 745                 750         


Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        755                 760                 765             


Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile 
    770                 775                 780                 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
785                 790                 795                 800 


Cys Gly Thr Lys Leu Gln Ile Thr Arg Thr Pro Leu Gly Asp Thr Thr 
                805                 810                 815     


His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile 
            820                 825                 830         


Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu 
        835                 840                 845             


Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly 
    850                 855                 860                 


Ala Pro His His His His His His 
865                 870         


<210> 47
<211> 594
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln 
        275                 280                 285             


Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    290                 295                 300                 


Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 
305                 310                 315                 320 


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                325                 330                 335     


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
            340                 345                 350         


Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val 
        355                 360                 365             


Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
            420                 425                 430         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser 
        435                 440                 445             


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly 
    450                 455                 460                 


Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
465                 470                 475                 480 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe 
                485                 490                 495     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
            500                 505                 510         


Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Cys Gly Thr Lys Leu Gln 
        515                 520                 525             


Ile Thr Arg Thr Pro Leu Gly Asp Thr Thr His Thr Ser Gly Lys Pro 
    530                 535                 540                 


Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe 
545                 550                 555                 560 


Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln 
                565                 570                 575     


Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His His His His 
            580                 585                 590         


His His 
        


<210> 48
<211> 872
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        275                 280                 285             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
    290                 295                 300                 


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
                325                 330                 335     


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            340                 345                 350         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
        355                 360                 365             


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                405                 410                 415     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            420                 425                 430         


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
        435                 440                 445             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    450                 455                 460                 


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
465                 470                 475                 480 


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                485                 490                 495     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
            500                 505                 510         


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
        515                 520                 525             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
545                 550                 555                 560 


Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys 
                565                 570                 575     


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln 
            580                 585                 590         


Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
        595                 600                 605             


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser 
    610                 615                 620                 


Arg Asp Asn Ser Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg 
625                 630                 635                 640 


Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His 
                645                 650                 655     


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    690                 695                 700                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
705                 710                 715                 720 


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
                725                 730                 735     


Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr 
            740                 745                 750         


Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        755                 760                 765             


Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile 
    770                 775                 780                 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
785                 790                 795                 800 


Cys Gly Thr Lys Leu Gln Ile Thr Arg Thr Pro Leu Gly Asp Thr Thr 
                805                 810                 815     


His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile 
            820                 825                 830         


Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu 
        835                 840                 845             


Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly 
    850                 855                 860                 


Ala Pro His His His His His His 
865                 870         


<210> 49
<211> 872
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        275                 280                 285             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
    290                 295                 300                 


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
                325                 330                 335     


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            340                 345                 350         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
        355                 360                 365             


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                405                 410                 415     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            420                 425                 430         


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
        435                 440                 445             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    450                 455                 460                 


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
465                 470                 475                 480 


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                485                 490                 495     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
            500                 505                 510         


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
        515                 520                 525             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
545                 550                 555                 560 


Gly Ala Glu Val Ala Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
                565                 570                 575     


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln 
            580                 585                 590         


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg 
        595                 600                 605             


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr 
    610                 615                 620                 


Arg Asp Lys Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg 
625                 630                 635                 640 


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
                645                 650                 655     


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    690                 695                 700                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
705                 710                 715                 720 


Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
                725                 730                 735     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Thr 
            740                 745                 750         


Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        755                 760                 765             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Phe 
    770                 775                 780                 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
785                 790                 795                 800 


Ser Gly Thr Lys Leu Glu Ile Asn Arg Thr Pro Leu Gly Asp Thr Thr 
                805                 810                 815     


His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile 
            820                 825                 830         


Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu 
        835                 840                 845             


Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly 
    850                 855                 860                 


Ala Pro His His His His His His 
865                 870         


<210> 50
<211> 872
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        275                 280                 285             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
    290                 295                 300                 


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
                325                 330                 335     


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            340                 345                 350         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
        355                 360                 365             


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                405                 410                 415     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            420                 425                 430         


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
        435                 440                 445             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    450                 455                 460                 


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
465                 470                 475                 480 


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                485                 490                 495     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
            500                 505                 510         


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
        515                 520                 525             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
545                 550                 555                 560 


Gly Ala Glu Val Ala Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
                565                 570                 575     


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln 
            580                 585                 590         


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg 
        595                 600                 605             


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr 
    610                 615                 620                 


Arg Asp Lys Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg 
625                 630                 635                 640 


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
                645                 650                 655     


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    690                 695                 700                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
705                 710                 715                 720 


Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
                725                 730                 735     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Thr 
            740                 745                 750         


Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        755                 760                 765             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Phe 
    770                 775                 780                 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
785                 790                 795                 800 


Ser Gly Thr Lys Leu Glu Ile Asn Arg Thr Pro Leu Gly Asp Thr Thr 
                805                 810                 815     


His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile 
            820                 825                 830         


Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu 
        835                 840                 845             


Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly 
    850                 855                 860                 


Ala Pro His His His His His His 
865                 870         


<210> 51
<211> 872
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        275                 280                 285             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
    290                 295                 300                 


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
                325                 330                 335     


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            340                 345                 350         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
        355                 360                 365             


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                405                 410                 415     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            420                 425                 430         


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
        435                 440                 445             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    450                 455                 460                 


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
465                 470                 475                 480 


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                485                 490                 495     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
            500                 505                 510         


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
        515                 520                 525             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
545                 550                 555                 560 


Gly Ala Glu Val Ala Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
                565                 570                 575     


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln 
            580                 585                 590         


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg 
        595                 600                 605             


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr 
    610                 615                 620                 


Arg Asp Lys Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg 
625                 630                 635                 640 


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
                645                 650                 655     


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    690                 695                 700                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
705                 710                 715                 720 


Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
                725                 730                 735     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Thr 
            740                 745                 750         


Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        755                 760                 765             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Phe 
    770                 775                 780                 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
785                 790                 795                 800 


Ser Gly Thr Lys Leu Glu Ile Asn Arg Thr Pro Leu Gly Asp Thr Thr 
                805                 810                 815     


His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile 
            820                 825                 830         


Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu 
        835                 840                 845             


Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly 
    850                 855                 860                 


Ala Pro His His His His His His 
865                 870         


<210> 52
<211> 872
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        275                 280                 285             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
    290                 295                 300                 


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
                325                 330                 335     


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            340                 345                 350         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
        355                 360                 365             


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                405                 410                 415     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            420                 425                 430         


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
        435                 440                 445             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    450                 455                 460                 


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
465                 470                 475                 480 


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                485                 490                 495     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
            500                 505                 510         


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
        515                 520                 525             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
545                 550                 555                 560 


Gly Ala Glu Val Ala Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
                565                 570                 575     


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln 
            580                 585                 590         


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg 
        595                 600                 605             


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr 
    610                 615                 620                 


Arg Asp Lys Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg 
625                 630                 635                 640 


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
                645                 650                 655     


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    690                 695                 700                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
705                 710                 715                 720 


Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
                725                 730                 735     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Thr 
            740                 745                 750         


Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        755                 760                 765             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Phe 
    770                 775                 780                 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
785                 790                 795                 800 


Ser Gly Thr Lys Leu Glu Ile Asn Arg Thr Pro Leu Gly Asp Thr Thr 
                805                 810                 815     


His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile 
            820                 825                 830         


Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu 
        835                 840                 845             


Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly 
    850                 855                 860                 


Ala Pro His His His His His His 
865                 870         


<210> 53
<211> 872
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        275                 280                 285             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
    290                 295                 300                 


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
                325                 330                 335     


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            340                 345                 350         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
        355                 360                 365             


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                405                 410                 415     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            420                 425                 430         


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
        435                 440                 445             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    450                 455                 460                 


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
465                 470                 475                 480 


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                485                 490                 495     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
            500                 505                 510         


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
        515                 520                 525             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
545                 550                 555                 560 


Gly Ala Glu Val Ala Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
                565                 570                 575     


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln 
            580                 585                 590         


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg 
        595                 600                 605             


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr 
    610                 615                 620                 


Arg Asp Lys Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg 
625                 630                 635                 640 


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
                645                 650                 655     


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    690                 695                 700                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
705                 710                 715                 720 


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
                725                 730                 735     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr 
            740                 745                 750         


Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        755                 760                 765             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    770                 775                 780                 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
785                 790                 795                 800 


Ser Gly Thr Lys Leu Glu Ile Asn Arg Thr Pro Leu Gly Asp Thr Thr 
                805                 810                 815     


His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile 
            820                 825                 830         


Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu 
        835                 840                 845             


Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly 
    850                 855                 860                 


Ala Pro His His His His His His 
865                 870         


<210> 54
<211> 872
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        275                 280                 285             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
    290                 295                 300                 


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
                325                 330                 335     


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            340                 345                 350         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
        355                 360                 365             


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                405                 410                 415     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            420                 425                 430         


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
        435                 440                 445             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    450                 455                 460                 


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
465                 470                 475                 480 


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                485                 490                 495     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
            500                 505                 510         


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
        515                 520                 525             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
545                 550                 555                 560 


Gly Ala Glu Val Ala Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
                565                 570                 575     


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln 
            580                 585                 590         


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg 
        595                 600                 605             


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr 
    610                 615                 620                 


Arg Asp Lys Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg 
625                 630                 635                 640 


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
                645                 650                 655     


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    690                 695                 700                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
705                 710                 715                 720 


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
                725                 730                 735     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr 
            740                 745                 750         


Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        755                 760                 765             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    770                 775                 780                 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
785                 790                 795                 800 


Ser Gly Thr Lys Leu Glu Ile Asn Arg Thr Pro Leu Gly Asp Thr Thr 
                805                 810                 815     


His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile 
            820                 825                 830         


Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu 
        835                 840                 845             


Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly 
    850                 855                 860                 


Ala Pro His His His His His His 
865                 870         


<210> 55
<211> 872
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        275                 280                 285             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
    290                 295                 300                 


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
                325                 330                 335     


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            340                 345                 350         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
        355                 360                 365             


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                405                 410                 415     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            420                 425                 430         


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
        435                 440                 445             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    450                 455                 460                 


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
465                 470                 475                 480 


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                485                 490                 495     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
            500                 505                 510         


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
        515                 520                 525             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
545                 550                 555                 560 


Gly Ala Glu Val Ala Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
                565                 570                 575     


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln 
            580                 585                 590         


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg 
        595                 600                 605             


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr 
    610                 615                 620                 


Arg Asp Lys Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg 
625                 630                 635                 640 


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
                645                 650                 655     


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    690                 695                 700                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
705                 710                 715                 720 


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
                725                 730                 735     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr 
            740                 745                 750         


Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        755                 760                 765             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    770                 775                 780                 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
785                 790                 795                 800 


Ser Gly Thr Lys Leu Glu Ile Asn Arg Thr Pro Leu Gly Asp Thr Thr 
                805                 810                 815     


His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile 
            820                 825                 830         


Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu 
        835                 840                 845             


Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly 
    850                 855                 860                 


Ala Pro His His His His His His 
865                 870         


<210> 56
<211> 872
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asp Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        275                 280                 285             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
    290                 295                 300                 


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
                325                 330                 335     


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            340                 345                 350         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
        355                 360                 365             


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                405                 410                 415     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            420                 425                 430         


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
        435                 440                 445             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    450                 455                 460                 


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
465                 470                 475                 480 


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                485                 490                 495     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
            500                 505                 510         


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
        515                 520                 525             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
545                 550                 555                 560 


Gly Ala Glu Val Ala Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
                565                 570                 575     


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln 
            580                 585                 590         


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg 
        595                 600                 605             


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr 
    610                 615                 620                 


Arg Asp Lys Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg 
625                 630                 635                 640 


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
                645                 650                 655     


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        675                 680                 685             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    690                 695                 700                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
705                 710                 715                 720 


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
                725                 730                 735     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr 
            740                 745                 750         


Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        755                 760                 765             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    770                 775                 780                 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
785                 790                 795                 800 


Ser Gly Thr Lys Leu Glu Ile Asn Arg Thr Pro Leu Gly Asp Thr Thr 
                805                 810                 815     


His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile 
            820                 825                 830         


Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu 
        835                 840                 845             


Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly 
    850                 855                 860                 


Ala Pro His His His His His His 
865                 870         


<210> 57
<211> 873
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val 
        275                 280                 285             


Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile 
    290                 295                 300                 


Ser Asp Tyr Leu Tyr Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg 
305                 310                 315                 320 


Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg 
                325                 330                 335     


Phe Ser Gly Ser Gly Ser Gly Ser Glu Phe Thr Leu Thr Ile Asn Ser 
            340                 345                 350         


Val Glu Pro Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser 
        355                 360                 365             


Phe Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
                405                 410                 415     


Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys 
            420                 425                 430         


Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asn Tyr Asp Ile Asn 
        435                 440                 445             


Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Trp Ile 
    450                 455                 460                 


Phe Pro Gly Asp Asp Ser Thr Gln Tyr Asn Glu Lys Phe Lys Gly Lys 
465                 470                 475                 480 


Ala Thr Leu Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu 
                485                 490                 495     


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln 
            500                 505                 510         


Thr Thr Gly Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        515                 520                 525             


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    530                 535                 540                 


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
545                 550                 555                 560 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                565                 570                 575     


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
            580                 585                 590         


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
        595                 600                 605             


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
    610                 615                 620                 


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
625                 630                 635                 640 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
                645                 650                 655     


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        675                 680                 685             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
    690                 695                 700                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
705                 710                 715                 720 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
                725                 730                 735     


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
            740                 745                 750         


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
        755                 760                 765             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
    770                 775                 780                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
785                 790                 795                 800 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr 
                805                 810                 815     


Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln 
            820                 825                 830         


Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala 
        835                 840                 845             


Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly 
    850                 855                 860                 


Gly Ala Pro His His His His His His 
865                 870             


<210> 58
<211> 870
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val 
        275                 280                 285             


Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile 
    290                 295                 300                 


Ser Asp Tyr Leu Tyr Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg 
305                 310                 315                 320 


Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg 
                325                 330                 335     


Phe Ser Gly Ser Gly Ser Gly Ser Glu Phe Thr Leu Thr Ile Asn Ser 
            340                 345                 350         


Val Glu Pro Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser 
        355                 360                 365             


Phe Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys Arg Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
                405                 410                 415     


Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys 
            420                 425                 430         


Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asn Tyr Asp Ile Asn 
        435                 440                 445             


Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Trp Ile 
    450                 455                 460                 


Phe Pro Gly Asp Asp Ser Thr Gln Tyr Asn Glu Lys Phe Lys Gly Lys 
465                 470                 475                 480 


Ala Thr Leu Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu 
                485                 490                 495     


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln 
            500                 505                 510         


Thr Thr Gly Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        515                 520                 525             


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    530                 535                 540                 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala 
545                 550                 555                 560 


Glu Val Ala Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
                565                 570                 575     


Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro 
            580                 585                 590         


Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr 
        595                 600                 605             


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Arg Asp 
    610                 615                 620                 


Lys Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp 
625                 630                 635                 640 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser 
                645                 650                 655     


Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        675                 680                 685             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    690                 695                 700                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
705                 710                 715                 720 


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
                725                 730                 735     


Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
            740                 745                 750         


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        755                 760                 765             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    770                 775                 780                 


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly 
785                 790                 795                 800 


Thr Lys Leu Glu Ile Asn Arg Thr Pro Leu Gly Asp Thr Thr His Thr 
                805                 810                 815     


Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly 
            820                 825                 830         


Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu 
        835                 840                 845             


Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro 
    850                 855                 860                 


His His His His His His 
865                 870 


<210> 59
<211> 488
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Lys Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
225                 230                 235                 240 


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala 
                245                 250                 255     


Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala 
            260                 265                 270         


Pro Gly Lys Cys Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly 
        275                 280                 285             


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Arg 
    290                 295                 300                 


Asp Asn Ser Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro 
305                 310                 315                 320 


Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr 
                325                 330                 335     


Ser Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    370                 375                 380                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
385                 390                 395                 400 


Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                405                 410                 415     


Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
            420                 425                 430         


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        435                 440                 445             


Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    450                 455                 460                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Cys 
465                 470                 475                 480 


Gly Thr Lys Leu Gln Ile Thr Arg 
                485             


<210> 60
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210> 61
<211> 488
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Lys Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly 
225                 230                 235                 240 


Ala Glu Val Ala Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
                245                 250                 255     


Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala 
            260                 265                 270         


Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly 
        275                 280                 285             


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Arg 
    290                 295                 300                 


Asp Lys Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser 
305                 310                 315                 320 


Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr 
                325                 330                 335     


Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    370                 375                 380                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
385                 390                 395                 400 


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                405                 410                 415     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Thr Ser 
            420                 425                 430         


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        435                 440                 445             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Phe Ala 
    450                 455                 460                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser 
465                 470                 475                 480 


Gly Thr Lys Leu Glu Ile Asn Arg 
                485             


<210> 62
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210> 63
<211> 488
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 63
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Lys Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly 
225                 230                 235                 240 


Ala Glu Val Ala Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
                245                 250                 255     


Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala 
            260                 265                 270         


Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly 
        275                 280                 285             


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Arg 
    290                 295                 300                 


Asp Lys Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser 
305                 310                 315                 320 


Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr 
                325                 330                 335     


Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    370                 375                 380                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
385                 390                 395                 400 


Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                405                 410                 415     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
            420                 425                 430         


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        435                 440                 445             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    450                 455                 460                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser 
465                 470                 475                 480 


Gly Thr Lys Leu Glu Ile Asn Arg 
                485             


<210> 64
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210> 65
<211> 491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Lys Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly 
225                 230                 235                 240 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                245                 250                 255     


Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala 
            260                 265                 270         


Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly 
        275                 280                 285             


Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp 
    290                 295                 300                 


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
305                 310                 315                 320 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn 
                325                 330                 335     


Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val 
    370                 375                 380                 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
385                 390                 395                 400 


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala 
                405                 410                 415     


Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly 
            420                 425                 430         


Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser 
        435                 440                 445             


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu 
    450                 455                 460                 


Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val 
465                 470                 475                 480 


Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                485                 490     


<210> 66
<211> 490
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
225                 230                 235                 240 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                245                 250                 255     


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
            260                 265                 270         


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
        275                 280                 285             


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
    290                 295                 300                 


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
305                 310                 315                 320 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
                325                 330                 335     


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
    370                 375                 380                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
385                 390                 395                 400 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
                405                 410                 415     


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
            420                 425                 430         


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
        435                 440                 445             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
    450                 455                 460                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
465                 470                 475                 480 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                485                 490 


<210> 67
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 67
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Leu Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210> 68
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 69
<211> 488
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 69
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Lys Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
225                 230                 235                 240 


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala 
                245                 250                 255     


Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala 
            260                 265                 270         


Pro Gly Lys Cys Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly 
        275                 280                 285             


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Arg 
    290                 295                 300                 


Asp Asn Ser Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro 
305                 310                 315                 320 


Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr 
                325                 330                 335     


Ser Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    370                 375                 380                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
385                 390                 395                 400 


Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                405                 410                 415     


Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
            420                 425                 430         


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        435                 440                 445             


Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    450                 455                 460                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Cys 
465                 470                 475                 480 


Gly Thr Lys Leu Gln Ile Thr Arg 
                485             


<210> 70
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 70
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly 
225                 230                 235                 240 


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser 
                245                 250                 255     


Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro 
            260                 265                 270         


Gly Lys Cys Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr 
        275                 280                 285             


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Arg Asp 
    290                 295                 300                 


Asn Ser Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu 
305                 310                 315                 320 


Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser 
                325                 330                 335     


Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    370                 375                 380                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
385                 390                 395                 400 


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
                405                 410                 415     


Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
            420                 425                 430         


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        435                 440                 445             


Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
    450                 455                 460                 


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Cys Gly 
465                 470                 475                 480 


Thr Lys Leu Gln Ile Thr Arg 
                485         


<210> 71
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 71
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Leu Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210> 72
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 73
<211> 488
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 73
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Lys Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly 
225                 230                 235                 240 


Ala Glu Val Ala Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
                245                 250                 255     


Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala 
            260                 265                 270         


Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly 
        275                 280                 285             


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Arg 
    290                 295                 300                 


Asp Lys Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser 
305                 310                 315                 320 


Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr 
                325                 330                 335     


Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    370                 375                 380                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
385                 390                 395                 400 


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                405                 410                 415     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Thr Ser 
            420                 425                 430         


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        435                 440                 445             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Phe Ala 
    450                 455                 460                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser 
465                 470                 475                 480 


Gly Thr Lys Leu Glu Ile Asn Arg 
                485             


<210> 74
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 74
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly 
225                 230                 235                 240 


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser 
                245                 250                 255     


Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro 
            260                 265                 270         


Gly Lys Cys Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr 
        275                 280                 285             


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Arg Asp 
    290                 295                 300                 


Asn Ser Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu 
305                 310                 315                 320 


Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser 
                325                 330                 335     


Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    370                 375                 380                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
385                 390                 395                 400 


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
                405                 410                 415     


Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
            420                 425                 430         


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        435                 440                 445             


Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
    450                 455                 460                 


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Cys Gly 
465                 470                 475                 480 


Thr Lys Leu Gln Ile Thr Arg 
                485         


<210> 75
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 75
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Leu Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210> 76
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 76
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 77
<211> 488
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 77
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Lys Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly 
225                 230                 235                 240 


Ala Glu Val Ala Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
                245                 250                 255     


Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala 
            260                 265                 270         


Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly 
        275                 280                 285             


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Arg 
    290                 295                 300                 


Asp Lys Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser 
305                 310                 315                 320 


Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr 
                325                 330                 335     


Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    370                 375                 380                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
385                 390                 395                 400 


Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                405                 410                 415     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
            420                 425                 430         


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        435                 440                 445             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    450                 455                 460                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser 
465                 470                 475                 480 


Gly Thr Lys Leu Glu Ile Asn Arg 
                485             


<210> 78
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 78
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly 
225                 230                 235                 240 


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser 
                245                 250                 255     


Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro 
            260                 265                 270         


Gly Lys Cys Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr 
        275                 280                 285             


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Arg Asp 
    290                 295                 300                 


Asn Ser Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu 
305                 310                 315                 320 


Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser 
                325                 330                 335     


Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    370                 375                 380                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
385                 390                 395                 400 


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
                405                 410                 415     


Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
            420                 425                 430         


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        435                 440                 445             


Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
    450                 455                 460                 


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Cys Gly 
465                 470                 475                 480 


Thr Lys Leu Gln Ile Thr Arg 
                485         


<210> 79
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 79
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Leu Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210> 80
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 80
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 81
<211> 384
<212> PRT
<213> Homo sapiens

<400> 81
Ala Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg 
1               5                   10                  15      


His Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly 
            20                  25                  30          


Tyr His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser 
        35                  40                  45              


Gln Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr 
    50                  55                  60                  


Met Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly 
65                  70                  75                  80  


Glu Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu 
                85                  90                  95      


Ile Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro 
            100                 105                 110         


Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala 
        115                 120                 125             


Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys 
    130                 135                 140                 


Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu 
145                 150                 155                 160 


Cys Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala 
                165                 170                 175     


Val Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val 
            180                 185                 190         


Val Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly 
        195                 200                 205             


Lys Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser 
    210                 215                 220                 


Asn Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu 
225                 230                 235                 240 


Trp Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu 
                245                 250                 255     


Pro Pro Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro 
            260                 265                 270         


Val Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala 
        275                 280                 285             


Ala Ser Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile 
    290                 295                 300                 


Leu Leu Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe 
305                 310                 315                 320 


Ala Pro Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala 
                325                 330                 335     


Trp Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr 
            340                 345                 350         


Tyr Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala 
        355                 360                 365             


Ser Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His Gly Pro Met Lys 
    370                 375                 380                 


<210> 82
<211> 330
<212> PRT
<213> Homo sapiens

<400> 82
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 83
<211> 326
<212> PRT
<213> Homo sapiens

<400> 83
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210> 84
<211> 377
<212> PRT
<213> Homo sapiens

<400> 84
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210> 85
<211> 452
<212> PRT
<213> Homo sapiens

<400> 85
Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Ala His 
                405                 410                 415     


Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr 
            420                 425                 430         


Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala 
        435                 440                 445             


Gly Thr Cys Tyr 
    450         


<210> 86
<211> 327
<212> PRT
<213> Homo sapiens

<400> 86
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210> 87
<211> 353
<212> PRT
<213> Homo sapiens

<400> 87
Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
        115                 120                 125             


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
    130                 135                 140                 


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
145                 150                 155                 160 


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
                165                 170                 175     


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
            180                 185                 190         


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
        195                 200                 205             


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
                245                 250                 255     


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
            260                 265                 270         


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
        275                 280                 285             


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
    290                 295                 300                 


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
305                 310                 315                 320 


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
                325                 330                 335     


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
            340                 345                 350         


Tyr 
    


<210> 88
<211> 340
<212> PRT
<213> Homo sapiens

<400> 88
Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Met Ala 
305                 310                 315                 320 


Gly Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp 
                325                 330                 335     


Gly Thr Cys Tyr 
            340 


<210> 89
<211> 106
<212> PRT
<213> Homo sapiens

<400> 89
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210> 90
<211> 39
<212> PRT
<213> Homo sapiens

<400> 90
Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
1               5                   10                  15      


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            20                  25                  30          


Ala Gln Ala Gly Lys Glu Pro 
        35                  


<210> 91
<211> 57
<212> PRT
<213> Homo sapiens

<400> 91
Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro Val Arg Gly Arg Glu 
1               5                   10                  15      


Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser Leu Glu Leu Met Gln 
            20                  25                  30          


Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln His Gln His Leu Leu Gln Lys Gln 
    50                  55          


<210> 92
<211> 52
<212> PRT
<213> Homo sapiens

<400> 92
Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln Val Arg Gly Arg Glu 
1               5                   10                  15      


Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser Leu Glu Leu Met Glu 
            20                  25                  30          


Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg Gln Gln Gln Gln Leu 
        35                  40                  45              


Leu Gln Arg Pro 
    50          


<210> 93
<211> 27
<212> PRT
<213> Homo sapiens

<400> 93
Gln Ala Ile Lys Lys Glu Leu Thr Gln Ile Lys Gln Lys Val Asp Ser 
1               5                   10                  15      


Leu Leu Glu Asn Leu Glu Lys Ile Glu Lys Glu 
            20                  25          


<210> 94
<211> 54
<212> PRT
<213> Homo sapiens

<400> 94
Ser Thr Arg Arg Ile Leu Gly Leu Ala Ile Glu Ser Gln Asp Ala Gly 
1               5                   10                  15      


Ile Lys Thr Ile Thr Met Leu Asp Glu Gln Lys Glu Gln Leu Asn Arg 
            20                  25                  30          


Ile Glu Glu Gly Leu Asp Gln Ile Asn Lys Asp Met Arg Glu Thr Glu 
        35                  40                  45              


Lys Thr Leu Thr Glu Leu 
    50                  


<210> 95
<211> 97
<212> PRT
<213> Homo sapiens

<400> 95
Met Cys Gly Ala Pro Ser Ala Thr Gln Pro Ala Thr Ala Glu Thr Gln 
1               5                   10                  15      


His Ile Ala Asp Gln Val Arg Ser Gln Leu Glu Glu Lys Glu Asn Lys 
            20                  25                  30          


Lys Phe Pro Val Phe Lys Ala Val Ser Phe Lys Ser Gln Val Val Ala 
        35                  40                  45              


Gly Thr Asn Tyr Phe Ile Lys Val His Val Gly Asp Glu Asp Phe Val 
    50                  55                  60                  


His Leu Arg Val Phe Gln Ser Leu Pro His Glu Asn Lys Pro Leu Thr 
65                  70                  75                  80  


Leu Ser Asn Tyr Gln Thr Asn Lys Ala Lys His Asp Glu Leu Thr Tyr 
                85                  90                  95      


Phe 
    


<210> 96
<211> 30
<212> PRT
<213> Homo sapiens

<400> 96
Asp Glu Ile Ser Met Met Gly Arg Val Val Lys Val Glu Lys Gln Val 
1               5                   10                  15      


Gln Ser Ile Glu His Lys Leu Asp Leu Leu Leu Gly Phe Tyr 
            20                  25                  30  


<210> 97
<211> 60
<212> PRT
<213> Homo sapiens

<400> 97
Thr Val Ala Glu Ala Lys Arg Gln Ala Ala Glu Asp Ala Leu Ala Val 
1               5                   10                  15      


Ile Asn Gln Gln Glu Asp Ser Ser Glu Ser Cys Trp Asn Cys Gly Arg 
            20                  25                  30          


Lys Ala Ser Glu Thr Cys Ser Gly Cys Asn Thr Ala Arg Tyr Cys Gly 
        35                  40                  45              


Ser Phe Cys Gln His Lys Asp Trp Glu Lys His His 
    50                  55                  60  


<210> 98
<211> 470
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 98
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Ala Ser His Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro 
225                 230                 235                 240 


Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
                245                 250                 255     


Asp Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
            260                 265                 270         


Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr Ala Tyr Asn Thr Ala 
        275                 280                 285             


Leu Ile Ser Arg Leu Asn Ile Tyr Arg Asp Asn Ser Lys Asn Gln Val 
    290                 295                 300                 


Phe Leu Glu Met Asn Ser Leu Gln Ala Glu Asp Thr Ala Met Tyr Tyr 
305                 310                 315                 320 


Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr Phe Asp Ala Trp Gly 
                325                 330                 335     


Cys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Ile Gln Glu Ser 
        355                 360                 365             


Ala Leu Thr Thr Pro Pro Gly Glu Thr Val Thr Leu Thr Cys Gly Ser 
    370                 375                 380                 


Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn Trp Val Gln Glu 
385                 390                 395                 400 


Lys Pro Asp His Cys Phe Thr Gly Leu Ile Gly Gly His Asn Asn Arg 
                405                 410                 415     


Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys 
            420                 425                 430         


Ala Ala Leu Thr Ile Ala Gly Thr Gln Thr Glu Asp Glu Ala Ile Tyr 
        435                 440                 445             


Phe Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile Gly Gly Gly Thr 
    450                 455                 460                 


Arg Leu Thr Val Leu Gly 
465                 470 


<210> 99
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 99
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Ala Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210> 100
<211> 319
<212> PRT
<213> Homo sapiens

<400> 100
Met Val Gly Lys Met Trp Pro Val Leu Trp Thr Leu Cys Ala Val Arg 
1               5                   10                  15      


Val Thr Val Asp Ala Ile Ser Val Glu Thr Pro Gln Asp Val Leu Arg 
            20                  25                  30          


Ala Ser Gln Gly Lys Ser Val Thr Leu Pro Cys Thr Tyr His Thr Ser 
        35                  40                  45              


Thr Ser Ser Arg Glu Gly Leu Ile Gln Trp Asp Lys Leu Leu Leu Thr 
    50                  55                  60                  


His Thr Glu Arg Val Val Ile Trp Pro Phe Ser Asn Lys Asn Tyr Ile 
65                  70                  75                  80  


His Gly Glu Leu Tyr Lys Asn Arg Val Ser Ile Ser Asn Asn Ala Glu 
                85                  90                  95      


Gln Ser Asp Ala Ser Ile Thr Ile Asp Gln Leu Thr Met Ala Asp Asn 
            100                 105                 110         


Gly Thr Tyr Glu Cys Ser Val Ser Leu Met Ser Asp Leu Glu Gly Asn 
        115                 120                 125             


Thr Lys Ser Arg Val Arg Leu Leu Val Leu Val Pro Pro Ser Lys Pro 
    130                 135                 140                 


Glu Cys Gly Ile Glu Gly Glu Thr Ile Ile Gly Asn Asn Ile Gln Leu 
145                 150                 155                 160 


Thr Cys Gln Ser Lys Glu Gly Ser Pro Thr Pro Gln Tyr Ser Trp Lys 
                165                 170                 175     


Arg Tyr Asn Ile Leu Asn Gln Glu Gln Pro Leu Ala Gln Pro Ala Ser 
            180                 185                 190         


Gly Gln Pro Val Ser Leu Lys Asn Ile Ser Thr Asp Thr Ser Gly Tyr 
        195                 200                 205             


Tyr Ile Cys Thr Ser Ser Asn Glu Glu Gly Thr Gln Phe Cys Asn Ile 
    210                 215                 220                 


Thr Val Ala Val Arg Ser Pro Ser Met Asn Val Ala Leu Tyr Val Gly 
225                 230                 235                 240 


Ile Ala Val Gly Val Val Ala Ala Leu Ile Ile Ile Gly Ile Ile Ile 
                245                 250                 255     


Tyr Cys Cys Cys Cys Arg Gly Lys Asp Asp Asn Thr Glu Asp Lys Glu 
            260                 265                 270         


Asp Ala Arg Pro Asn Arg Glu Ala Tyr Glu Glu Pro Pro Glu Gln Leu 
        275                 280                 285             


Arg Glu Leu Ser Arg Glu Arg Glu Glu Glu Asp Asp Tyr Arg Gln Glu 
    290                 295                 300                 


Glu Gln Arg Ser Thr Gly Arg Glu Ser Pro Asp His Leu Asp Gln 
305                 310                 315                 


<210> 101
<211> 214
<212> PRT
<213> Homo sapiens

<400> 101
Ile Ser Val Glu Thr Pro Gln Asp Val Leu Arg Ala Ser Gln Gly Lys 
1               5                   10                  15      


Ser Val Thr Leu Pro Cys Thr Tyr His Thr Ser Thr Ser Ser Arg Glu 
            20                  25                  30          


Gly Leu Ile Gln Trp Asp Lys Leu Leu Leu Thr His Thr Glu Arg Val 
        35                  40                  45              


Val Ile Trp Pro Phe Ser Asn Lys Asn Tyr Ile His Gly Glu Leu Tyr 
    50                  55                  60                  


Lys Asn Arg Val Ser Ile Ser Asn Asn Ala Glu Gln Ser Asp Ala Ser 
65                  70                  75                  80  


Ile Thr Ile Asp Gln Leu Thr Met Ala Asp Asn Gly Thr Tyr Glu Cys 
                85                  90                  95      


Ser Val Ser Leu Met Ser Asp Leu Glu Gly Asn Thr Lys Ser Arg Val 
            100                 105                 110         


Arg Leu Leu Val Leu Val Pro Pro Ser Lys Pro Glu Cys Gly Ile Glu 
        115                 120                 125             


Gly Glu Thr Ile Ile Gly Asn Asn Ile Gln Leu Thr Cys Gln Ser Lys 
    130                 135                 140                 


Glu Gly Ser Pro Thr Pro Gln Tyr Ser Trp Lys Arg Tyr Asn Ile Leu 
145                 150                 155                 160 


Asn Gln Glu Gln Pro Leu Ala Gln Pro Ala Ser Gly Gln Pro Val Ser 
                165                 170                 175     


Leu Lys Asn Ile Ser Thr Asp Thr Ser Gly Tyr Tyr Ile Cys Thr Ser 
            180                 185                 190         


Ser Asn Glu Glu Gly Thr Gln Phe Cys Asn Ile Thr Val Ala Val Arg 
        195                 200                 205             


Ser Pro Ser Met Asn Val 
    210                 


<210> 102
<211> 490
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 102
Asp Ile Gln Met Thr Gln Ser Gln Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Val Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Phe Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly 
225                 230                 235                 240 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                245                 250                 255     


Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro 
            260                 265                 270         


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr 
        275                 280                 285             


Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn 
    290                 295                 300                 


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
305                 310                 315                 320 


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr 
                325                 330                 335     


Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val 
    370                 375                 380                 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
385                 390                 395                 400 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn 
                405                 410                 415     


Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly 
            420                 425                 430         


His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
        435                 440                 445             


Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp 
    450                 455                 460                 


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile 
465                 470                 475                 480 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                485                 490 


<210> 103
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 103
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210> 104
<211> 597
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 104
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Gln Ser Ser Leu Ser Thr 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Arg Thr Val Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys 
            180                 185                 190         


Thr Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn 
    210                 215                 220                 


Val Gln Pro Glu Asp Phe Ala Asp Tyr Phe Cys Leu Gln His Trp Ser 
225                 230                 235                 240 


Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        275                 280                 285             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
    290                 295                 300                 


Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr Ala Tyr Asn Thr 
                325                 330                 335     


Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
        355                 360                 365             


Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr Phe Asp Ala Trp 
    370                 375                 380                 


Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro 
            420                 425                 430         


Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
        435                 440                 445             


Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn Trp Val Gln Gln 
    450                 455                 460                 


Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly His Asn Asn Arg 
465                 470                 475                 480 


Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                485                 490                 495     


Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp Glu Ala Glu Tyr 
            500                 505                 510         


Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile Gly Gly Gly Thr 
        515                 520                 525             


Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr Thr His Thr Ser 
    530                 535                 540                 


Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg 
545                 550                 555                 560 


Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys 
                565                 570                 575     


Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His 
            580                 585                 590         


His His His His His 
        595         


<210> 105
<211> 597
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 105
Asp Ile Gln Met Thr Gln Ser Gln Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Val Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Phe Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr Asp Met Ser Trp Val Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly 
            180                 185                 190         


Gly Ser Tyr Thr Tyr Tyr Leu Asp Ser Val Lys Gly Arg Phe Thr Ile 
        195                 200                 205             


Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
    210                 215                 220                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Pro Thr Thr Val Val 
225                 230                 235                 240 


Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        275                 280                 285             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
    290                 295                 300                 


Thr Asp Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Gly Thr Ala Tyr Asn Thr 
                325                 330                 335     


Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
        355                 360                 365             


Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr Asn Tyr Phe Asp Ala Trp 
    370                 375                 380                 


Gly Cys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro 
            420                 425                 430         


Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
        435                 440                 445             


Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr Ala Asn Trp Val Gln Gln 
    450                 455                 460                 


Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile Gly Gly His Asn Asn Arg 
465                 470                 475                 480 


Pro Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                485                 490                 495     


Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro Glu Asp Glu Ala Glu Tyr 
            500                 505                 510         


Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp Val Ile Gly Gly Gly Thr 
        515                 520                 525             


Lys Leu Thr Val Leu Gly Thr Pro Leu Gly Asp Thr Thr His Thr Ser 
    530                 535                 540                 


Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg 
545                 550                 555                 560 


Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys 
                565                 570                 575     


Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Gly Gly Ala Pro His 
            580                 585                 590         


His His His His His 
        595         


<210> 106
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 106
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Thr Val Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210> 107
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 107
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
            100                 105         


<210> 108
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 108
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210> 109
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 109
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 110
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 110
Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   


<210> 111
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 111
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 112
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 112
Gly Gly Gly Gly Ser 
1               5   


<210> 113
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 113
Gly Gly Gly Gly Ser 
1               5   


<210> 114
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 114
His His His His His His 
1               5       


<210> 115
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> SITE
<222> (1)..(75) 
<223> This sequence may encompass 1-15 "Gly Gly Gly Gly Ser"
      repeating units

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 115
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75  


<210> 116
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> SITE
<222> (1)..(150) 
<223> This sequence may encompass 1-20, 25, or 30 
      "Gly Gly Gly Gly Ser" repeating units

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 116
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser 
145                 150 


