                         SEQUENCE LISTING

<110>  SENGENICS CORPORATION PTE LTD
       CHINA MEDICAL UNIVERSITY HOSPITAL
 
<120>  BIOMARKERS FOR PREDICTING IMMUNOGENICITY AND THERAPEUTIC 
       RESPONSES TO ADALIMUMAB IN RHEUMATOID ARTHRITIS PATIENTS

<130>  MJ550/10

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  1224
<212>  DNA
<213>  Escherichia coli

<400>  1
atggctgaga acggcgacaa cgagaagatg gctgctctcg aggctaagat ctgccaccag       60

atcgagtact acttcggcga cttcaacctg ccccgtgaca agttcctgaa ggaacagatc      120

aagctggacg agggctgggt gcccctcgag atcatgatca agttcaaccg tctgaaccgc      180

ctgaccaccg acttcaacgt gatcgtcgag gctctgtcca agtccaaggc tgagctgatg      240

gaaatctccg aggacaagac caagatccgt cgttccccat ccaagcccct gcccgaagtg      300

accgacgagt acaagaacga cgtgaagaac cgttccgtgt acatcaaggg tttccccacc      360

gacgctaccc tggacgacat caaggaatgg ctcgaggaca agggccaggt gctgaacatc      420

cagatgcgtc gtaccctgca caaggctttc aagggttcca tcttcgtggt gttcgactcc      480

atcgagtccg ctaagaagtt cgtcgagact cccggccaga agtacaagga aaccgacctg      540

ctgatcctgt tcaaggacga ctacttcgcc aagaagaacg aggaacgcaa gcagaacaag      600

gtcgaggcca agctgcgtgc taagcaagag caagaggcta agcagaagct ggaagaggac      660

gctgagatga agtccctgga agagaagatc ggttgcctgc tgaagttctc cggcgacctg      720

gacgaccaga cctgccgcga ggacctgcac atcctgttct ccaaccacgg cgagatcaag      780

tggatcgact tcgtgcgtgg tgctaaggaa ggcatcatcc tcttcaagga aaaggccaag      840

gaagctctgg gcaaggctaa ggacgctaac aacggcaacc tgcagctgcg taacaaggaa      900

gtgacctggg aggtcctcga gggcgaggtc gagaaggaag ccctgaagaa gatcatcgag      960

gaccagcaag agtccctgaa caagtggaag tccaagggtc gtcgtttcaa gggcaaggga     1020

aagggcaaca aggctgctca gcccggttcc ggaaagggaa aggtgcagtt ccagggcaag     1080

aagaccaagt tcgcttccga cgacgagcac gatgagcacg acgagaacgg tgctaccggt     1140

cccgtgaagc gtgctcgtga agagactgac aaggaagaac ccgcttccaa gcagcaaaag     1200

accgagaacg gcgctggcga ccag                                            1224


<210>  2
<211>  1614
<212>  DNA
<213>  Escherichia coli

<400>  2
atggaggaat ctgtaaacca aatgcagcca ctgaatgaga agcagatagc caattctcag       60

gatggatatg tatggcaagt cactgacatg aatcgactac accggttctt atgtttcggt      120

tctgaaggtg ggacttatta tatcaaagaa cagaagttgg gccttgaaaa tgctgaagct      180

ttaattagat tgattgaaga tggcagagga tgtgaagtga tacaagaaat aaagtcattt      240

agtcaagaag gcagaaccac aaagcaagag cctatgctct ttgcacttgc catttgttcc      300

cagtgctccg acataagcac aaaacaagca gcatttaaag ctgtttctga agtttgtcgc      360

attcctaccc atctctttac ttttatccag tttaagaaag atctgaagga aagcatgaaa      420

tgtggcatgt ggggtcgtgc cctccggaag gctatagcgg actggtacaa tgagaaaggt      480

ggcatggccc ttgctctggc agttacaaaa tataaacaga gaaatggctg gtctcacaaa      540

gatctattaa gattgtcaca tcttaaacct tccagtgaag gacttgcaat tgtgaccaaa      600

tatattacaa agggctggaa agaagttcat gaattgtata aagaaaaagc actctctgtg      660

gagactgaaa aattattaaa gtatctggag gctgtagaga aagtgaagcg cacaagagat      720

gagctagaag tcattcatct aatagaagaa catagattag ttagagaaca tcttttaaca      780

aatcacttaa agtctaaaga ggtatggaag gctttgttac aagaaatgcc gcttactgca      840

ttactaagga atctaggaaa gatgactgct aattcagtac ttgaaccagg aaattcagaa      900

gtatctttag tatgtgaaaa actgtgtaat gaaaaactat taaaaaaggc tcgtatacat      960

ccatttcata ttttgatcgc attagaaact tacaagacag gtcatggtct cagagggaaa     1020

ctgaagtggc gccctgatga agaaattttg aaagcattgg atgctgcttt ttataaaaca     1080

tttaagacag ttgaaccaac tggaaaacgt ttcttactag ctgttgatgt cagtgcttct     1140

atgaaccaaa gagttttggg tagtatactc aacgctagta cagttgctgc agcaatgtgc     1200

atggttgtca cacgaacaga aaaagattct tatgtagttg ctttttccga tgaaatggta     1260

ccatgtccag tgactacaga tatgacctta caacaggttt taatggctat gagtcagatc     1320

ccagcaggtg gaactgattg ctctcttcca atgatctggg ctcagaagac aaacacacct     1380

gctgatgtct tcattgtatt cactgataat gagacctttg ctggaggtgt ccatcctgct     1440

attgctctga gggagtatcg aaagaaaatg gatattccag ctaaattgat tgtttgtgga     1500

atgacatcaa atggtttcac cattgcagac ccagatgata gaggcatgtt ggatatgtgc     1560

ggctttgata ctggagctct ggatgtaatt cgaaatttca cattagatat gatt           1614


<210>  3
<211>  2511
<212>  DNA
<213>  Escherichia coli

<400>  3
atggctagca aacgaaaatc tacaactcca tgcatggttc ggacatcaca agtagtagaa       60

caagatgtgc ccgaggaagt agacagggcc aaagagaaag gaatcggcac accacagcct      120

gacgtggcca aggacagttg ggcagcagaa cttgaaaact cttccaaaga aaacgaagtg      180

atagaggtga aatctatggg ggaaagccag tccaaaaaac tccaaggtgg ttatgagtgc      240

aaatactgcc cctactccac gcaaaacctg aacgagttca cggagcatgt cgacatgcag      300

catcccaacg tgattctcaa ccccctctac gtgtgtgcag aatgtaactt cacaaccaaa      360

aagtacgact ccctatccga ccacaactcc aagttccatc ccggggaggc caacttcaag      420

ctgaagttaa ttaaacgcaa taatcaaact gtcttggaac agtccatcga aaccaccaac      480

catgtcgtgt ccatcaccac cagtggccct ggaactggtg acagtgattc tgggatctcg      540

gtgagtaaaa cccccatcat gaagcctgga aaaccaaaag cggatgccaa gaaggtgccc      600

aagaagcccg aggagatcac ccccgagaac cacgtggaag ggaccgcccg cctggtgaca      660

gacacagctg agatcctctc gagactcggc ggggtggagc tcctccaaga cacattagga      720

cacgtcatgc cttctgtaca gctgccacca aatatcaacc ttgtgcccaa ggtccctgtc      780

ccactaaata ctaccaaata caactctgcc ctggatacaa atgccacgat gatcaactct      840

ttcaacaagt ttccttaccc gacccaggct gagttgtcct ggctgacagc tgcctccaaa      900

cacccagagg agcacatcag aatctggttt gccacccagc gcttaaagca tggcatcagc      960

tggtccccag aagaggtgga ggaggcccgg aagaagatgt tcaacggcac catccagtca     1020

gtacccccga ccatcactgt gctgcccgcc cagttggccc ccacaaaggt gacgcagccc     1080

atcctccaga cggctctacc gtgccagatc ctcggccaga ctagcctggt gctgactcag     1140

gtgaccagcg ggtcaacaac cgtctcttgc tcccccatca cacttgccgt ggcaggagtc     1200

accaaccatg gccagaagag acccttggtg actccccaag ctgcccccga acccaagcgt     1260

ccacacatcg ctcaggtgcc agagccccca cccaaggtgg ccaacccccc gctcacacca     1320

gccagtgacc gcaagaagac aaaggagcag atagcacatc tcaaggccag ctttctccag     1380

agccagttcc ctgacgatgc cgaggtttac cggctcatcg aggtgactgg ccttgccagg     1440

agcgagatca agaagtggtt cagtgaccac cgatatcggt gtcaaagggg catcgtccac     1500

atcaccagcg aatcccttgc caaagaccag ttggccatcg cggcctcccg acacggtcgc     1560

acgtatcatg cgtacccaga ctttgccccc cagaagttca aagagaaaac acagggtcag     1620

gttaaaatct tggaagacag ctttttgaaa agttcttttc ctacccaagc agaactggat     1680

cggctaaggg tggagaccaa gctgagcagg agagagatcg actcctggtt ctcggagagg     1740

cggaagcttc gagacagcat ggaacaagct gtcttggatt ccatggggtc tggcaaaaaa     1800

ggccaagatg tgggagcccc caatggtgct ctgtctcgac tcgaccagct ctccggtgcc     1860

cagttaacaa gttctctgcc cagcccttcg ccagcaattg caaaaagtca agaacaggtt     1920

catctcctga ggagcacgtt tgcaagaacc cagtggccta ctccccagga gtacgaccag     1980

ttagcggcca agactggcct ggtccgaact gagattgtgc gttggttcaa ggagaacaga     2040

tgcttgctga aaacgggaac cgtgaagtgg atggagcagt accagcacca gcccatggca     2100

gatgatcacg gctacgatgc cgtagcaagg aaagcaacaa aacccatggc cgagagccca     2160

aagaacgggg gtgatgtggt tccacaatat tacaaggacc ccaaaaagct ctgcgaagag     2220

gacttggaga agttggtgac cagggtaaaa gtaggcagcg agccagcaaa agactgtttg     2280

ccagcaaagc cctcagaggc cacctcagac cggtcagagg gcagcagccg ggacggccag     2340

ggtagcgacg agaacgagga gtcgagcgtt gtggattacg tggaggtgac ggtcggggag     2400

gaggatgcga tctcagatag atcagatagc tggagtcagg ctgcggcaga aggtgtgtcg     2460

gaactggctg aatcagactc cgactgcgtc cctgcagagg ctggccaggc c              2511


<210>  4
<211>  1083
<212>  DNA
<213>  Escherichia coli

<400>  4
atggagcagc cacaggagga agcccctgag gtccgggaag aggaggagaa agaggaagtg       60

gcagaggcag aaggagcccc agagctcaat gggggaccac agcatgcact tccttccagc      120

agctacacag acctctcccg gagctcctcg ccaccctcac tgctggacca actgcagatg      180

ggctgtgacg gggcctcatg cggcagcctc aacatggagt gccgggtgtg cggggacaag      240

gcatcgggct tccactacgg tgttcatgca tgtgaggggt gcaagggctt cttccgtcgt      300

acgatccgca tgaagctgga gtacgagaag tgtgagcgca gctgcaagat tcagaagaag      360

aaccgcaaca agtgccagta ctgccgcttc cagaagtgcc tggcactggg catgtcacac      420

aacgctatcc gttttggtcg gatgccggag gctgagaaga ggaagctggt ggcagggctg      480

actgcaaatg aggggagcca gtacaaccca caggtggccg acctgaaggc cttctccaag      540

cacatctaca atgcctacct gaaaaacttc aacatgacca aaaagaaggc ccgcagcatc      600

ctcaccggca aagccagcca cacggcgccc tttgtgatcc acgacatcga gacattgtgg      660

caggcagaga aggggctggt gtggaagcag ttggtgaatg gcctgcctcc ctacaaggag      720

atcagcgtgc acgtcttcta ccgctgccag tgcaccacag tggagaccgt gcgggagctc      780

actgagttcg ccaagagcat ccccagcttc agcagcctct tcctcaacga ccaggttacc      840

cttctcaagt atggcgtgca cgaggccatc ttcgccatgc tggcctctat cgtcaacaag      900

gacgggctgc tggtagccaa cggcagtggc tttgtcaccc gtgagttcct gcgcagcctc      960

cgcaaaccct tcagtgatat cattgagcct aagtttgaat ttgctgtcaa gttcaacgcc     1020

ctggaacttg atgacagtga cctggcccta ttcattgcgg ccatcattct gtgtggaggt     1080

gag                                                                   1083


<210>  5
<211>  539
<212>  DNA
<213>  Escherichia coli

<400>  5
tggaacagcc cacctcttcc accaacggcg agaagcgcaa gtccccctgc gagtccaaca       60

acaagaaaaa cgacgagatg caagaggctc ccaaccgtgt gctggctccc aagcagtccc      120

tgcaaaagac caagaccatc gagtacctga ccatcatcgt gtactactac cgcaagcaca      180

ccaagatcaa ctccaaccag ctcgagaagg accagtcccg cgagaactcc atcaaccccg      240

tgcaagagga agaggacgag ggcctggact ccgctgaggg atcctcccaa gaagatgagg      300

acctggacag ctccgagggt tccagccaag aggatgaaga tctcgactcc tccgagggca      360

gctcccaaga ggacgaggac ttggattcct ccgagggatc tagtcaagag gacgaggatc      420

tggactcttc cgaaggctca tctcaagaag atgaagattt ggacccccct gagggtagca      480

gtcaagagga tgaggacctc gattccagcg agggctcctc acaagagggt ggcgaggat       539


<210>  6
<211>  1023
<212>  DNA
<213>  Escherichia coli

<400>  6
atggaacgcg agaaagagca gttccgcaag ctgttcatcg gtggcctgtc cttcgagact       60

accgaggaat ccctgcgcaa ctactacgag cagtggggca agctgaccga ctgcgtggtc      120

atgcgtgacc ccgcttccaa gcgttcccgt ggtttcggtt tcgtgacctt ctccagcatg      180

gctgaggtgg acgctgctat ggctgctcgt ccccactcca tcgacggtcg tgtggtcgag      240

cctaagcgtg ctgtggctcg tgaagagtcc ggcaagcctg gtgctcacgt gaccgtgaag      300

aagctgttcg ttggcggtat caaagaggac accgaggaac accacctgag ggactacttc      360

gaggaatacg gcaagatcga caccatcgag atcatcaccg accgtcagtc cggaaagaag      420

cgcggcttcg gcttcgtcac tttcgacgac cacgaccccg tggacaagat cgtgctgcag      480

aagtaccaca ccatcaacgg tcacaacgct gaagtgcgca aggctctgtc ccgtcaagag      540

atgcaagagg tgcagtcctc ccgttccggt cgtggtggca acttcggatt cggcgactct      600

cgcggtggtg gcggaaactt cggtcctggt cccggttcca acttccgtgg tggttccgac      660

ggttacggct ccggaagagg tttcggcgac ggctacaacg gctacggtgg tggtcctggc      720

ggtggaaatt tcggtggttc ccctggttac ggtggcggtc gcggtggata cggcggaggt      780

ggtccaggat acggcaacca gggtggcggt tacggcggtg gttacgacaa ctacggtggc      840

ggcaactacg gttccggaaa ctacaacgac ttcggcaatt acaaccagca gccctccaac      900

tacggcccca tgaagtctgg caatttcggc ggctcccgta acatgggtgg tccttacggt      960

ggtggaaatt acggtcccgg tggttccggt ggctctggtg gctacggcgg tcgttcccgt     1020

tac                                                                   1023


<210>  7
<211>  1029
<212>  DNA
<213>  Escherichia coli

<400>  7
atgaacatac acaggtctac ccccatcaca atagcgagat atgggagatc gcggaacaaa       60

acccaggatt tcgaagagtt gtcgtctata aggtccgcgg agcccagcca gagtttcagc      120

ccgaacctcg gctccccgag cccgcccgag actccgaact tgtcgcattg cgtttcttgt      180

atcgggaaat acttattgtt ggaacctctg gagggagacc acgtttttcg tgccgtgcat      240

ctgcacagcg gagaggagct ggtgtgcaag gtgtttgata tcagctgcta ccaggaatcc      300

ctggcaccgt gcttttgcct gtctgctcat agtaacatca accaaatcac tgaaattatc      360

ctgggtgaga ccaaagccta tgtgttcttt gagcgaagct atggggacat gcattccttc      420

gtccgcacct gcaagaagct gagagaggag gaggcagcca gactgttcta ccagattgcc      480

tcggcagtgg cccactgcca tgacgggggg ctggtgctgc gggacctcaa gctgcggaaa      540

ttcatcttta aggacgaaga gaggactcgg gtcaagctgg aaagcctgga agacgcctac      600

attctgcggg gagatgatga ttccctctcc gacaagcatg gctgcccggc ttacgtaagc      660

ccagagatct tgaacaccag tggcagctac tcgggcaaag cagccgacgt gtggagcctg      720

ggggtgatgc tgtacaccat gttggtgggg cggtaccctt tccatgacat tgaacccagc      780

tccctcttca gcaagatccg gcgtggccag ttcaacattc cagagactct gtcgcccaag      840

gccaagtgcc tcatccgaag cattctgcgt cgggagccct cagagcggct gacctcgcag      900

gaaattctgg accatccttg gttttctaca gattttagcg tctcgaattc agcatatggt      960

gctaaggaag tgtctgacca gctggtgccg gacgtcaaca tggaagagaa cttggaccct     1020

ttctttaac                                                             1029


<210>  8
<211>  1392
<212>  DNA
<213>  Escherichia coli

<400>  8
atgtcctccc gttccaccaa ggacctgatc aagtctaagt ggggttccaa gccctccaac       60

tccaagtccg agactaccct cgagaagctg aagggcgaga tcgctcacct caagacctcc      120

gtggacgaga tcacctccgg caagggcaag ctgaccgaca aggaacgtca ccgtctgctc      180

gagaagatcc gtgtgctcga ggctgagaag gaaaagaacg cttaccagct gactgagaag      240

gacaaggaaa tccagcgtct gcgcgaccag ctgaaggctc gttactccac caccgctctg      300

ctggaacagc tggaagaaac cacccgcgag ggcgagcgtc gcgagcaggt cctgaaggct      360

ctgtccgaag agaaggacgt gctgaagcag cagctgtccg ctgctacctc ccgtatcgct      420

gagctggaat ccaagaccaa caccctgcgt ctgtcccaga ccgtggctcc caactgcttc      480

aactcctcca tcaacaacat ccacgagatg gaaatccaac tgaaggacgc tctcgagaag      540

aaccagcagt ggctggtgta cgaccagcag cgcgaggtgt acgtgaaggg cctgctggct      600

aagatcttcg agctggaaaa gaagaccgag actgctgctc actccctgcc ccagcagacc      660

aagaagcccg agtccgaggg ttacctgcaa gaggaaaagc agaagtgcta caacgacctg      720

ctggcttccg ctaagaagga cctggaagtc gagcgtcaga ccatcaccca gctgtccttc      780

gagctgtccg agttccgtag gaagtacgaa gagactcaga aggaagtcca caacctgaac      840

cagctgctgt actcccagcg tcgtgctgac gtgcagcacc tcgaggacga ccgtcacaag      900

actgagaaga tccagaagct gcgcgaagag aacgatatcg ctcgtggcaa gctcgaggaa      960

gagaagaagc gttccgagga actgctgtcc caggtgcagt tcctgtacac ctccctgctc     1020

aagcagcaag aggaacagac ccgtgtggct ctgttggagc agcagatgca ggcttgcacc     1080

ctggacttcg agaacgagaa gctggaccgt cagcacgtcc agcaccagct gcacgtgatc     1140

ctgaaggaac tgcgcaaggc tcgtaaccag atcacccagt tggagtccct gaagcagctg     1200

cacgagttcg ctatcaccga gcccctggtc accttccaag gcgagactga gaaccgcgag     1260

aaggtggccg cttcccccaa gtcccccacc gctgctctga acgagtccct ggtcgagtgc     1320

cccaagtgca acatccagta ccccgctacc gagcaccgtg acctgctggt gcacgtcgag     1380

tactgctcca ag                                                         1392


<210>  9
<211>  1104
<212>  DNA
<213>  Escherichia coli

<400>  9
atgtcggtgg cggggctgaa gaagcagttc tacaaggcga gccagctggt cagtgagaag       60

gtcggagggg ccgaggggac caagctggat gatgacttca aagagatgga gaagaaggtg      120

gatgtcacca gcaaggcggt gacagaagtg ctggccagga ccatcgagta cctgcagccc      180

aacccagcct cgcgggctaa gctgaccatg ctcaacacgg tgtccaagat ccggggccag      240

gtgaagaacc ccggctaccc gcagtcggag gggcttctgg gcgagtgcat gatccgccac      300

gggaaggagc tgggcggcga gtccaacttt ggtgacgcat tgctggatgc cggcgagtcc      360

atgaagcgcc tggcagaggt gaaggactcc ctggacatcg aggtcaagca gaacttcatt      420

gaccccctcc agaacctgtg cgagaaagac ctgaaggaga tccagcacca cctgaagaaa      480

ctggagggcc gccgcctgga ctttgactac aagaagaagc ggcagggcaa gatccccgat      540

gaggagctac gccaggcgct ggagaagttc gaggagtcca aggaggtggc agaaaccagc      600

atgcacaacc tcctggagac tgacatcgag caggtgagtc agctctcggc cctggtggat      660

gcacagctgg actaccaccg gcaggccgtg cagatcctgg acgagctggc ggagaagctc      720

aagcgcagga tgcgggaagc ttcctcacgc cctaagcggg agtataagcc gaagccccgg      780

gagccctttg accttggaga gcctgagcag tccaacgggg gcttcccctg caccacagcc      840

cccaagatcg cagcttcatc gtctttccga tcttccgaca agcccatccg gacccctagc      900

cggagcatgc cgcccctgga ccagccgagc tgcaaggcgc tgtacgactt cgagcccgag      960

aacgacgggg agctgggctt ccatgagggc gacgtcatca cgctgaccaa ccagatcgat     1020

gagaactggt acgagggcat gctggacggc cagtcgggct tcttcccgct cagctacgtg     1080

gaggtgcttg tgcccctgcc gcag                                            1104


<210>  10
<211>  927
<212>  DNA
<213>  Escherichia coli

<400>  10
atggagcagc tgctgcgcgc cgagctgcgc accgcgaccc tgcgggcctt cggcggcccc       60

ggcgccggct gcatcagcga gggccgagcc tacgacacgg acgcaggccc agtgttcgtc      120

aaagtcaacc gcaggacgca ggcccggcag atgtttgagg gggaggtggc cagcctggag      180

gccctccgga gcacgggcct ggtgcgggtg ccgaggccca tgaaggtcat cgacctgccg      240

ggaggtgggg ccgcctttgt gatggagcat ttgaagatga agagcttgag cagtcaagca      300

tcaaaacttg gagagcagat ggcagatttg catctttaca accagaagct cagggagaag      360

ttgaaggagg aggagaacac agtgggccga agaggtgagg gtgctgagcc tcagtatgtg      420

gacaagttcg gcttccacac ggtgacgtgc tgcggcttca tcccgcaggt gaatgagtgg      480

caggatgact ggccgacctt tttcgcccgg caccggctcc aggcgcagct ggacctcatt      540

gagaaggact atgctgaccg agaggcacga gaactctggt cccggctaca ggtgaagatc      600

ccggatctgt tttgtggcct agagattgtc cccgcgttgc tccacgggga tctctggtcg      660

ggaaacgtgg ctgaggacga cgtggggccc attatttacg acccggcttc cttctatggc      720

cattccgagt ttgaactggc aatcgccttg atgtttgggg ggttccccag atccttcttc      780

accgcctacc accggaagat ccccaaggct ccgggcttcg accagcggct gctgctctac      840

cagctgttta actacctgaa ccactggaac cacttcgggc gggagtacag gagcccttcg      900

ttgggcacca tgcgaaggct gctcaag                                          927


<210>  11
<211>  1110
<212>  DNA
<213>  Escherichia coli

<400>  11
atgaagatca aagatgccaa gaaaccctct ttcccatggt ttggcatgga cattggggga       60

actctagtaa agctctcgta ctttgaacct attgatatca cagcagagga agagcaagaa      120

gaagttgaga gtttaaaaag tattcggaaa tatttgactt ctaacgtggc atatggatcc      180

accggcattc gggatgtaca ccttgaactg aaagatttaa cactttttgg ccgaagaggg      240

aacttgcact ttatcaggtt tccaacccag gacctgccta cttttatcca aatgggaaga      300

gataaaaact tctcaacatt gcagacggtg ctatgtgcta caggaggtgg tgcttacaag      360

tttgaaaaag attttcgcac aattggaaac ctccacctgc acaaactgga tgaacttgac      420

tgccttgtaa agggcttgct gtatatagac tctgtcagtt tcaatggaca agccgagtgc      480

tattattttg ctaatgcctc agaacctgag cgatgccaaa agatgccttt taacctggat      540

gatccctatc cactgcttgt agtgaacatt ggctcaggag tcagtatttt agcagtccat      600

tccaaagaca actataaacg agtgactggg acaagccttg gagggggtac ctttctgggt      660

ttatgcagtt tattgactgg ctgtgaaagt tttgaagagg ctcttgaaat ggcatccaaa      720

ggtgatagca cacaagctga caagctggtc cgtgatattt atggaggaga ttatgaaaga      780

tttggtttgc caggttgggc tgtagcatct agttttggga atatgattta taaggagaag      840

cgagaatctg ttagtaaaga agatctggca agagctactt tagttactat caccaataac      900

attggttctg tggcacgaat gtgtgctgtt aatgagaaaa taaacagagt tgtctttgtt      960

ggaaactttt tacgtgtcaa taccctctca atgaaacttt tggcatatgc actggattac     1020

tggtcaaaag gtcaactaaa agcattgttt ctagaacatg agggttactt tggagcagtt     1080

ggtgcacttc ttgggctgcc aaatttcagc                                      1110


<210>  12
<211>  579
<212>  DNA
<213>  Escherichia coli

<400>  12
atgggcaagc agaactccaa gctgcgtccc gaggtgctgc aggacctgcg cgagaacacc       60

gagttcaccg accacgagct gcaagagtgg tacaagggtt tcctgaagga ctgccccacc      120

ggtcacctga ccgtggacga gttcaagaag atctacgcta acttcttccc ctacggcgac      180

gcttccaagt tcgctgagca cgtgttccgt accttcgaca ccaacggcga cggcaccatc      240

gacttccgcg agttcatcat cgctctgtcc gtgacctccc gtggcaagct cgagcaaaag      300

ctgaagtggg ctttctcgat gtacgacctg gacggcaacg gttacatctc ccgttccgag      360

atgctcgaga tcgtgcaggc tatctacaag atggtgtcct ccgtgatgaa gatgcccgag      420

gacgagtcca cccccgagaa gcgtaccgac aagatcttcc gtcagatgga caccaacaac      480

gacggaaagc tgtccctgga agagttcatc cgtggtgcta agtccgaccc ctccatcgtg      540

cgtctgctgc agtgcgaccc atcctccgct tcccagttc                             579


<210>  13
<211>  1470
<212>  DNA
<213>  Escherichia coli

<400>  13
atggaacaga agccaagcaa ggtggagtgt gggtcagacc cagaggagaa cagtgccagg       60

tcaccagatg gaaagcgaaa aagaaagaac ggccaatgtt ccctgaaaac cagcatgtca      120

gggtatatcc ctagttacct ggacaaagac gagcagtgtg tcgtgtgtgg ggacaaggca      180

actggttatc actaccgctg tatcacttgt gagggctgca agggcttctt tcgccgcaca      240

atccagaaga acctccatcc cacctattcc tgcaaatatg acagctgctg tgtcattgac      300

aagatcaccc gcaatcagtg ccagctgtgc cgcttcaaga agtgcatcgc cgtgggcatg      360

gccatggact tggttctaga tgactcgaag cgggtggcca agcgtaagct gattgagcag      420

aaccgggagc ggcggcggaa ggaggagatg atccgatcac tgcagcagcg accagagccc      480

actcctgaag agtgggatct gatccacatt gccacagagg cccatcgcag caccaatgcc      540

cagggcagcc attggaaaca gaggcggaaa ttcctgcccg atgacattgg ccagtcaccc      600

attgtctcca tgccggacgg agacaaggtg gacctggaag ccttcagcga gtttaccaag      660

atcatcaccc cggccatcac ccgtgtggtg gactttgcca aaaaactgcc catgttctcc      720

gagctgcctt gcgaagacca gatcatcctc ctgaaggggt gctgcatgga gatcatgtcc      780

ctgcgggcgg ctgtccgcta cgaccctgag agcgacaccc tgacgctgag tggggagatg      840

gctgtcaagc gggagcagct caagaatggc ggcctgggcg tagtctccga cgccatcttt      900

gaactgggca agtcactctc tgcctttaac ctggatgaca cggaagtggc tctgctgcag      960

gctgtgctgc taatgtcaac agaccgctcg ggcctgctgt gtgtggacaa gatcgagaag     1020

agtcaggagg cgtacctgct ggcgttcgag cactacgtca accaccgcaa acacaacatt     1080

ccgcacttct ggcccaagct gctgatgaag gagagagaag tgcagagttc gattctgtac     1140

aagggggcag cggcagaagg ccggccgggc gggtcactgg gcgtccaccc ggaaggacag     1200

cagcttctcg gaatgcatgt tgttcagggt ccgcaggtcc ggcagcttga gcagcagctt     1260

ggtgaagcgg gaagtctcca agggccggtt cttcagcacc agagcccgaa gagcccgcag     1320

cagcgtctcc tggagctgct ccaccgaagc ggaattctcc atgcccgagc ggtctgtggg     1380

gaagacgaca gcagtgaggc ggactccccg agctcctctg aggaggaacc ggaggtctgc     1440

gaggacctgg caggcaatgc agcctctccc                                      1470


<210>  14
<211>  783
<212>  DNA
<213>  Escherichia coli

<400>  14
atggaaaagg tccgccgcga gggtgtcaag gtcatgccca acgctatcgt gcagtccgtg       60

ggcgtgtcct ccggcaagct gctgatcaag ctgaaggacg gtcgcaaggt ggaaaccgac      120

cacatcgtgg ctgctgtggg cctcgagccc aacgtcgagc tggctaagac cggtggcctc      180

gagatcgact ccgacttcgg tggtttccgt gtgaacgctg agctgcaggc tcgttccaac      240

atctgggtgg ccggcgacgc tgcttgcttc tacgacatca agctgggtcg tcgtcgtgtc      300

gagcaccacg accacgctgt ggtgtccggt cgtctggctg gcgagaacat gaccggtgct      360

gctaagccct actggcacca gtccatgttc tggtccgacc tgggtcccga cgtgggttac      420

gaggctatcg gcctggtgga ctcctccctg cccaccgtgg gagtgttcgc taaggctacc      480

gctcaggaca accccaagtc cgctaccgag cagtccggca ccggtatccg ttccgagtcc      540

gagactgagt ccgaggcttc cgagatcacc atccccccct ccacccccgc tgtgcctcaa      600

gctcctgtgc agggcgagga ctacggcaag ggtgtcatct tctacctgcg tgacaaggtg      660

gtcgtgggta tcgtgctgtg gaacatcttc aaccgtatgc ctatcgcccg caagatcatc      720

aaggacggcg agcagcacga ggacctgaac gaggtggcca agctgttcaa catccacgag      780

gac                                                                    783


<210>  15
<211>  1383
<212>  DNA
<213>  Escherichia coli

<400>  15
atgaacaact ttggtaatga agagtttgac tgccacttcc tcgatgaagg ttttactgcc       60

aaggacattc tggaccagaa aattaatgaa gtttcttctt ctgatgataa ggatgccttc      120

tatgtggcag acctgggaga cattctaaag aaacatctga ggtggttaaa agctctccct      180

cgtgtcaccc ccttttatgc agtcaaatgt aatgatagca aagccatcgt gaagaccctt      240

gctgctaccg ggacaggatt tgactgtgct agcaagactg aaatacagtt ggtgcagagt      300

ctgggggtgc ctccagagag gattatctat gcaaatcctt gtaaacaagt atctcaaatt      360

aagtatgctg ctaataatgg agtccagatg atgacttttg atagtgaagt tgagttgatg      420

aaagttgcca gagcacatcc caaagcaaag ttggttttgc ggattgccac tgatgattcc      480

aaagcagtct gtcgtctcag tgtgaaattc ggtgccacgc tcagaaccag caggctcctt      540

ttggaacggg cgaaagagct aaatatcgat gttgttggtg tcagcttcca tgtaggaagc      600

ggctgtaccg atcctgagac cttcgtgcag gcaatctctg atgcccgctg tgtttttgac      660

atgggggctg aggttggttt cagcatgtat ctgcttgata ttggcggtgg ctttcctgga      720

tctgaggatg tgaaacttaa atttgaagag atcaccggcg taatcaaccc agcgttggac      780

aaatactttc cgtcagactc tggagtgaga atcatagctg agcccggcag atactatgtt      840

gcatcagctt tcacgcttgc agttaatatc attgccaaga aaattgtatt aaaggaacag      900

acgggctctg atgacgaaga tgagtcgagt gagcagacct ttatgtatta tgtgaatgat      960

ggcgtctatg gatcatttaa ttgcatactc tatgaccacg cacatgtaaa gccccttctg     1020

caaaagagac ctaaaccaga tgagaagtat tattcatcca gcatatgggg accaacatgt     1080

gatggcctcg atcggattgt tgagcgctgt gacctgcctg aaatgcatgt gggtgattgg     1140

atgctctttg aaaacatggg cgcttacact gttgctgctg cctctacgtt caatggcttc     1200

cagaggccga cgatctacta tgtgatgtca gggcctgcgt ggcaactcat gcagcaattc     1260

cagaaccccg acttcccacc cgaagtagag gaacaggatg ccagcaccct gcctgtgtct     1320

tgtgcctggg agagtgggat gaaacgccac agagcagcct gtgcttcggc tagtattaat     1380

gtg                                                                   1383


<210>  16
<211>  1572
<212>  DNA
<213>  Escherichia coli

<400>  16
atgggggacg aggacgacga tgagagctgc gccgtggagc tgcggatcac agaagccaac       60

ctgaccgggc acgaggagaa ggtgagcgtg gagaacttcg agctgctcaa ggtgctgggc      120

acgggagcct acggcaaggt gttcctggtg cggaaggcgg gcgggcacga cgcggggaag      180

ctgtacgcca tgaaggtgct gcgcaaggcg gcgctggtgc agcgcgccaa gacgcaggag      240

cacacgcgca ccgagcgctc ggtgctggag ctggtgcgcc aggcgccctt cctggtcacg      300

ctgcactacg ctttccagac ggatgccaag ctgcacctca tcctggacta tgtgagcggc      360

ggggagatgt tcacccacct ctaccagcgc cagtacttca aggaggctga ggtgcgcgtg      420

tatgggggtg agatcgtgct ggccctggaa cacctgcaca agctcggcat catttaccga      480

gacctgaaac tggagaatgt gctgctggac tccgagggcc acattgtcct cacggacttc      540

gggctgagca aggagttcct gacggaggag aaagagcgga ccttctcctt ctgtggcacc      600

atcgagtaca tggcccccga aatcatccgt agcaagacgg ggcatggcaa ggctgtggac      660

tggtggagcc tgggcatctt gctcttcgag ctgctgacgg gggcctcgcc cttcaccctg      720

gagggcgaga ggaacacgca ggctgaggtg tctcgacgga tcctgaagtg ctcccctccc      780

ttcccccctc ggatcgggcc cgtggcgcag gacctgctgc agcggctgct ttgtaaggat      840

cctaagaagc gattgggcgc ggggccccag ggggcacaag aagtccggaa ccatcccttc      900

ttccagggcc tcgattgggt ggctctggct gccaggaaga ttccagcccc attccggccc      960

caaatccgct cagagctgga tgtgggcaac tttgcggagg aattcactcg gctggagcct     1020

gtctactcac cccctggcag ccccccacct ggggaccccc gaatctttca gggatactcc     1080

tttgtggcac cctccattct ctttgaccac aacaacgcgg ccgagatcat gtgcaaaatc     1140

cgcgaggggc gcttctccct tgacggggag gcctggcagg gtgtatccga ggaagccaag     1200

gagctggtcc gagggctcct gaccgtggac cccgccaagc ggctgaagct cgagggactg     1260

cggggcagct cgtggctgca ggacggcagc gcgcgctcct cgcccccgct ccggacgccc     1320

gacgtgctcg agtcctctgg gcccgcagtg cgctcgggtc tcaacgccac cttcatggca     1380

ttcaaccggg gcaagcggga gggcttcttc ctgaagagcg tggagaacgc acccctggcc     1440

aagcggcgga agcagaagct gcggagcgcc accgcctccc gccggggctc ccctgcacca     1500

gccaacccgg gccgagcccc cgtcgccgcc aaaggggccc cccgccgagc caacggcccc     1560

ctgcccccct cc                                                         1572


<210>  17
<211>  1941
<212>  DNA
<213>  Escherichia coli

<400>  17
atgaggagcg ggaaggcctc ctgcaccctg gagaccgtgt gggaagacaa gcacaagtat       60

gaggaggccg agcggcgctt ctacgaacac gaggccacac aggcggccgc ctccgcccag      120

cagctgccag ccgaggggcc agccatgaat gggcccggcc aggacgaccc tgaggacgct      180

gatgaggcgg aagcccctga cggcggcagc aggcgtgatc ccaggaagag ccaggacagc      240

aggaagcccc tgcagaaaaa gaggaagcgc tcccccaaga gcgggctcgg ccccgcggac      300

ctggccctcc tgggcctctc ggccgaacgt gtgtggctgg acaagtcact tttcgaccag      360

gcagagagct cctaccgcca gaagctggca gatgtggctg cccaggcagc ctggcctcct      420

gccttggccc cttggggtct ctgcacccat ggaaaccagg tggcctgcca ccacgtgacc      480

tgggggatct gggtcaacaa gtcctccttc gaccaggctg agcgggcctt cgtggagtgg      540

tctcaggccc tgttgctggc ccccgagggc agccgcaggc aggggactcc caacacaggc      600

cagcaggtgg ccgtccccga cctggcccac cagcccagcc caccggtcaa tggccagccc      660

ccgctgggca gcctgcaggc actggttcgg gaggtgtggc tggagaagcc ccggtatgat      720

gcagccgaga ggggcttcta cgaggccctg tttgacggcc atcccccagg gaaggtgcgc      780

ctgcaagagc gagccggcct ggccgagggt gcccggcggg gccgcagaga ccggcggggc      840

cgcaacatct tagggaacaa gcgggccggg ctgcgacggg ccgatgggga ggccccctct      900

gccttgccct actgttactt cctgcagaag gatgcagagg ccccctggct cagcaagcct      960

gcctacgaca gcgccgagtg ccgccaccac gctgccgagg ccctgcgtgt ggcctggtgc     1020

ctcgaagctg cctccctgtc tcaccgaccc ggtcctcggt ctggcctgtc cgtgtccagc     1080

ctgagaccca acagaaaaat ggctacaaac ttcctagcac atgagaagat ctggttcgac     1140

aagttcaaat atgacgacgc agaaaggaga ttctacgagc agatgaacgg gcctgtggca     1200

ggtgcctccc gccaggagaa cggcgccagc gtgatcctcc gtgacattgc gagagccaga     1260

gagaacatcc agaaatccct ggctggaagc tcaggccccg gggcctccag cggcaccagc     1320

ggagaccacg gtgagctcgt cgtccggatt gccagtctgg aagtggagaa ccagagtctg     1380

cgtggcgtgg tacaggagct gcagcaggcc atctccaagc tggaggcccg gctgaacgtg     1440

ctggagaaga gctcgcctgg ccaccgggcc acggccccac agacccagca cgtatctccc     1500

atgcgccaag tggagccccc agccaagaag ccagccacac cagcagagga tgacgaggat     1560

gatgacattg acctgtttgg cagtgacaat gaggaggagg acaaggaggc ggcacagctg     1620

cgggaggagc ggctacggca gtacgcggag aagaaggcca agaagcctgc actggtggcc     1680

aagtcctcca tcctgctgga tgtcaagcct tgggatgatg agacggacat ggcccagctg     1740

gaggcctgtg tgcgctctat ccagctggac gggctggtct ggggggcttc caagctggtg     1800

cccgtgggct acggtatccg gaagctacag attcagtgtg tggtggagga cgacaaggtg     1860

gggacagact tgctggagga ggagatcacc aagtttgagg agcacgtgca gagtgtcgat     1920

atcgcagctt tcaacaagat c                                               1941


<210>  18
<211>  1407
<212>  DNA
<213>  Escherichia coli

<400>  18
atggaggaaa gaatggaaat gatttctgaa aggccaaaag agagtatgta ttcctggaac       60

aaaactgcag agaaaagtga ttttgaagct gtagaagcac ttatgtcaat gagctgcagt      120

tggaagtctg attttaagaa atacgttgaa aacagacctg ttacaccagt atctgatttg      180

tcagaggaag agaatctgct tccgggaaca cctgattttc atacaatccc agcattttgt      240

ttgactccac cttacagtcc ttctgacttt gaaccctctc aagtgtcaaa tctgatggca      300

ccagcgccat ctactgtaca cttcaagtca ctctcagata ctgccaaacc tcacattgcc      360

gcacctttca aagaggaaga aaagagccca gtatctgccc ccaaactccc caaagctcag      420

gcaacaagtg tgattcgtca tacagctgat gcccagctat gtaaccacca gacctgccca      480

atgaaagcag ccagcatcct caactatcag aacaattctt ttagaagaag aacccaccta      540

aatgttgagg ctgcaagaaa gaacatacca tgtgccgctg tgtcaccaaa cagatccaaa      600

tgtgagagaa acacagtggc agatgttgat gagaaagcaa gtgctgcact ttatgacttt      660

tctgtgcctt cctcagagac ggtcatctgc aggtctcagc cagcccctgt gtccccacaa      720

cagaagtcag tgttggtctc tccacctgca gtatctgcag ggggagtgcc acctatgccg      780

gtcatctgcc agatggttcc ccttcctgcc aacaaccctg ttgtgacaac agtcgttccc      840

agcactcctc ccagccagcc accagccgtt tgcccccctg ttgtgttcat gggcacacaa      900

gtccccaaag gcgctgtcat gtttgtggta ccccagcccg ttgtgcagag ttcaaagcct      960

ccggtggtga gcccgaatgg caccagactc tctcccattg cccctgctcc tgggttttcc     1020

ccttcagcag caaaagtcac tcctcagatt gattcatcaa ggataaggag tcacatctgt     1080

agccacccag gatgtggcaa gacatacttt aaaagttccc atctgaaggc ccacacgagg     1140

acgcacacag gagaaaagcc tttcagctgt agctggaaag gttgtgaaag gaggtttgcc     1200

cgttctgatg aactgtccag acacaggcga acccacacgg gtgagaagaa atttgcgtgc     1260

cccatgtgtg accggcggtt catgaggagt gaccatttga ccaagcatgc ccggcgccat     1320

ctatcagcca agaagctacc aaactggcag atggaagtga gcaagctaaa tgacattgct     1380

ctacctccaa cccctgctcc cacacag                                         1407


<210>  19
<211>  2928
<212>  DNA
<213>  Escherichia coli

<400>  19
atggaactgc aggctgctcg tgcttgcttc gctctgctgt ggggttgcgc tttggctgct       60

gcagctgctg ctcagggcaa agaggtggtc ctgctggact tcgctgctgc cggtggcgaa      120

ctgggatggc tgactcaccc ttacggcaag ggctgggacc tgatgcagaa catcatgaac      180

gacatgccca tctacatgta ctccgtgtgc aacgtgatgt ccggcgacca ggacaactgg      240

ctgcgtacca actgggtgta ccgtggcgag gctgagcgca tcttcatcga gctgaagttc      300

accgtgcgcg actgcaactc cttccctggt ggtgcttcca gctgcaaaga gactttcaac      360

ctgtactacg ctgagtccga cctggactac ggcaccaact tccagaagcg tctgttcacc      420

aagatcgaca ctatcgctcc cgacgagatc accgtgtcct ccgacttcga ggctcgtcac      480

gtgaagctga acgtcgagga acgctccgtg ggtcccctga cccgcaaggg attctacctg      540

gctttccagg acatcggtgc ttgcgtggcc ctgctgtccg tgcgtgtgta ctacaagaag      600

tgccccgagc tgctccaggg cctggctcac ttccctgaga ctatcgctgg ttccgacgct      660

ccctccctgg ctaccgttgc tggtacttgc gtggaccacg ctgtggtgcc acctggtggc      720

gaggaacctc gtatgcactg cgctgtggac ggcgagtggc tggtgcctat cggtcaatgc      780

ctgtgccagg ctggttacga gaaggtcgag gacgcttgcc aggcttgctc ccccggtttc      840

ttcaagttcg aggcttccga gtccccctgc ctggaatgcc ctgaacacac cctgccttcc      900

ccagagggtg ctacctcctg cgagtgcgaa gagggcttct tccgtgctcc ccaggacccc      960

gcttctatgc cttgcacccg tcctccctcc gctccccact acctgactgc tgtcggcatg     1020

ggtgctaagg tcgagctgcg ttggaccccc cctcaggatt ctggtggtcg cgaggacatc     1080

gtctactccg tgacctgcga gcagtgctgg cctgagtctg gcgaatgcgg tccctgcgag     1140

gcttctgtgc gctactctga gcctcctcac ggcctgaccc gtacctctgt gaccgtgtcc     1200

gacctcgagc cccacatgaa ctacaccttc accgtcgagg cccgtaacgg tgtctccgga     1260

ctggtcacct cccgttcctt ccgtaccgct tccgtgtcca tcaaccagac cgagcccccc     1320

aaagtgcgcc tggaaggacg ttctaccacc tccctgtccg tgtcttggtc catcccccca     1380

cctcagcagt cccgtgtgtg gaagtacgaa gtgacctacc gcaagaaggg cgactccaac     1440

tcttacaacg tgcgtcgtac cgagggtttc agcgtgaccc tggacgacct ggctcccgac     1500

accacctacc tggtgcaagt gcaggctctg acccaagagg gccagggtgc tggttccaag     1560

gtgcacgagt tccagaccct gtcccccgag ggttccggaa acttggctgt gatcggcggt     1620

gtcgctgtgg gtgtcgtgct gctgttggtg ctggctggtg tcggcttctt catccaccgt     1680

cgtcgcaaga accagcgtgc tcgtcagtcc cctgaggacg tgtacttctc caagtccgag     1740

cagctgaagc ccctcaagac ctacgtggac ccccacactt acgaggaccc caaccaggct     1800

gtgctcaagt tcactaccga gatccacccc tcctgcgtga cccgtcagaa agtgatcggt     1860

gctggcgagt tcggcgaggt gtacaaggga atgctcaaga cttcctccgg caagaaagag     1920

gtgcccgtcg ctatcaagac cctgaaggct ggctacaccg agaagcagcg tgtggacttc     1980

ctgggagagg ctggtatcat gggccagttc tcccaccaca acatcatccg tctggaaggt     2040

gtcatctcca agtacaagcc catgatgatc attaccgagt acatggaaaa cggcgccctg     2100

gacaagttcc tgcgcgagaa ggatggcgag ttctccgtgc tgcagctcgt gggaatgctg     2160

cgtggtatcg ctgctggcat gaagtacctg gccaacatga attacgtgca cagggacctg     2220

gctgctcgca acatcctggt caactccaac ctcgtgtgca aggtgtcaga cttcggcctg     2280

tcccgcgtgc tcgaggacga tcctgaggct acctacacca cctccggtgg aaagatcccc     2340

atccgttgga ccgctcccga ggctatctct taccgcaagt tcacctccgc ttccgacgtg     2400

tggtccttcg gtatcgtgat gtgggaagtg atgacctacg gcgagcgccc ctactgggag     2460

ctgtctaacc acgaagtcat gaaggctatc aacgacggtt tccgtctgcc cacccctatg     2520

gactgcccct ccgctatcta ccagctgatg atgcaatgct ggcagcaaga gcgtgctagg     2580

cgtcccaagt tcgctgacat cgtgtctatc ctcgacaagc tgatccgcgc tcctgactcc     2640

ctgaaaaccc tggctgactt cgacccccgt gtgtccatcc gcctgccttc tacctctggc     2700

tccgagggtg tccctttccg tactgtgtcc gagtggctcg agtccatcaa gatgcagcag     2760

tacaccgagc acttcatggc tgctggttac accgctatcg agaaggtggt gcagatgacc     2820

aacgacgaca tcaagcgtat cggcgtgcgt ctgcccggtc accagaagag gatcgcttac     2880

tccctgctgg gcctgaagga ccaagtgaac accgtgggta tccccatc                  2928


<210>  20
<211>  1143
<212>  DNA
<213>  Escherichia coli

<400>  20
atggagtctg gcagtaccgc cgccagtgag gaggcacgca gccttcgaga atgtgagctc       60

tacgtccaga agcataacat tcaagcgctg ctcaaagatt ctattgtgca gttgtgcact      120

gctcgacctg agagacccat ggcattcctc agggaatact ttgagaggtt ggagaaggag      180

gaggcaaaac agattcagaa tctgcagaaa gcaggcactc gtacagactc aagggaggat      240

gagatttctc ctcctccacc caacccagtg gttaaaggta ggaggcgacg aggtgctatc      300

agcgctgagg tctacacgga ggaagatgcg gcatcctatg ttagaaaggt tataccaaaa      360

gattacaaga caatggccgc tttagccaaa gccattgaaa agaatgtgct gttttcacat      420

cttgatgata atgagagaag tgatattttt gatgccatgt tttcggtctc ctttatcgca      480

ggagagactg tgattcagca aggtgatgaa ggggataact tctatgtgat tgatcaagga      540

gagacggatg tctatgttaa caatgaatgg gcaaccagtg ttggggaagg agggagcttt      600

ggagaacttg ctttgattta tggaacaccg agagcagcca ctgtcaaagc aaagacaaat      660

gtgaaattgt ggggcatcga ccgagacagc tatagaagaa tcctcatggg aagcacactg      720

agaaagcgga agatgtatga ggaattcctt agtaaagtct ctattttaga gtctctggac      780

aagtgggaac gtcttacggt agctgatgca ttggaaccag tgcagtttga agatgggcag      840

aagattgtgg tgcagggaga accaggggat gagttcttca ttattttaga ggggtcagct      900

gctgtgctac aacgtcggtc agaaaatgaa gagtttgttg aagtgggaag attggggcct      960

tctgattatt ttggtgaaat tgcactactg atgaatcgtc ctcgtgctgc cacagttgtt     1020

gctcgtggcc ccttgaagtg cgttaagctg gaccgaccta gatttgaacg tgttcttggc     1080

ccatgctcag acatcctcaa acgaaacatc cagcagtaca acagttttgt gtcactgtct     1140

gtc                                                                   1143


<210>  21
<211>  855
<212>  DNA
<213>  Escherichia coli

<400>  21
atgaaccggc ttccggatga ctacgacccc tacgcggttg aagagcctag cgacgaggag       60

ccggctttga gcagctctga ggatgaagtg gatgtgcttt tacatggaac tcctgaccaa      120

aaacgaaaac tcatcagaga atgtcttacc ggagaaagtg aatcatctag tgaagatgaa      180

tttgaaaagg agatggaagc tgaattaaat tctaccatga aaacaatgga ggacaagtta      240

tcctctctgg gaactggatc ttcctcagga aatggaaaag ttgcaacagc tccgacaagg      300

tactacgatg atatatattt tgattctgat tccgaggatg aagacagagc agtacaggtg      360

accaagaaaa aaaagaagaa acaacacaag attccaacaa atgacgaatt actgtatgat      420

cctgaaaaag ataacagaga tcaggcctgg gttgatgcac agagaagggg ttaccatggt      480

ttgggaccac agagatcacg tgaacaacag cctgttccaa atagtgatgc tgtcttgaat      540

tgtcctgcct gcatgaccac actttgcctt gattgccaaa ggcatgaatc atacaaaact      600

caatatagag caatgtttgt aatgaattgt tctattaaca aagaggaggt tctaagatat      660

aaagcctcag agaacaggaa gaaaaggcgg gtccataaga agatgaggtc taaccaggaa      720

gatgctgctg agaaggcaga gacagatgtg gaagaaatct atcacccagt catgtgcact      780

gaatgttcca ctgaagtggc agtctacgac aaggatgaag tctttcattt tttcaatgtt      840

ttagcaagcc attcc                                                       855


<210>  22
<211>  408
<212>  PRT
<213>  Escherichia coli

<400>  22

Met Ala Glu Asn Gly Asp Asn Glu Lys Met Ala Ala Leu Glu Ala Lys 
1               5                   10                  15      


Ile Cys His Gln Ile Glu Tyr Tyr Phe Gly Asp Phe Asn Leu Pro Arg 
            20                  25                  30          


Asp Lys Phe Leu Lys Glu Gln Ile Lys Leu Asp Glu Gly Trp Val Pro 
        35                  40                  45              


Leu Glu Ile Met Ile Lys Phe Asn Arg Leu Asn Arg Leu Thr Thr Asp 
    50                  55                  60                  


Phe Asn Val Ile Val Glu Ala Leu Ser Lys Ser Lys Ala Glu Leu Met 
65                  70                  75                  80  


Glu Ile Ser Glu Asp Lys Thr Lys Ile Arg Arg Ser Pro Ser Lys Pro 
                85                  90                  95      


Leu Pro Glu Val Thr Asp Glu Tyr Lys Asn Asp Val Lys Asn Arg Ser 
            100                 105                 110         


Val Tyr Ile Lys Gly Phe Pro Thr Asp Ala Thr Leu Asp Asp Ile Lys 
        115                 120                 125             


Glu Trp Leu Glu Asp Lys Gly Gln Val Leu Asn Ile Gln Met Arg Arg 
    130                 135                 140                 


Thr Leu His Lys Ala Phe Lys Gly Ser Ile Phe Val Val Phe Asp Ser 
145                 150                 155                 160 


Ile Glu Ser Ala Lys Lys Phe Val Glu Thr Pro Gly Gln Lys Tyr Lys 
                165                 170                 175     


Glu Thr Asp Leu Leu Ile Leu Phe Lys Asp Asp Tyr Phe Ala Lys Lys 
            180                 185                 190         


Asn Glu Glu Arg Lys Gln Asn Lys Val Glu Ala Lys Leu Arg Ala Lys 
        195                 200                 205             


Gln Glu Gln Glu Ala Lys Gln Lys Leu Glu Glu Asp Ala Glu Met Lys 
    210                 215                 220                 


Ser Leu Glu Glu Lys Ile Gly Cys Leu Leu Lys Phe Ser Gly Asp Leu 
225                 230                 235                 240 


Asp Asp Gln Thr Cys Arg Glu Asp Leu His Ile Leu Phe Ser Asn His 
                245                 250                 255     


Gly Glu Ile Lys Trp Ile Asp Phe Val Arg Gly Ala Lys Glu Gly Ile 
            260                 265                 270         


Ile Leu Phe Lys Glu Lys Ala Lys Glu Ala Leu Gly Lys Ala Lys Asp 
        275                 280                 285             


Ala Asn Asn Gly Asn Leu Gln Leu Arg Asn Lys Glu Val Thr Trp Glu 
    290                 295                 300                 


Val Leu Glu Gly Glu Val Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu 
305                 310                 315                 320 


Asp Gln Gln Glu Ser Leu Asn Lys Trp Lys Ser Lys Gly Arg Arg Phe 
                325                 330                 335     


Lys Gly Lys Gly Lys Gly Asn Lys Ala Ala Gln Pro Gly Ser Gly Lys 
            340                 345                 350         


Gly Lys Val Gln Phe Gln Gly Lys Lys Thr Lys Phe Ala Ser Asp Asp 
        355                 360                 365             


Glu His Asp Glu His Asp Glu Asn Gly Ala Thr Gly Pro Val Lys Arg 
    370                 375                 380                 


Ala Arg Glu Glu Thr Asp Lys Glu Glu Pro Ala Ser Lys Gln Gln Lys 
385                 390                 395                 400 


Thr Glu Asn Gly Ala Gly Asp Gln 
                405             


<210>  23
<211>  538
<212>  PRT
<213>  Escherichia coli

<400>  23

Met Glu Glu Ser Val Asn Gln Met Gln Pro Leu Asn Glu Lys Gln Ile 
1               5                   10                  15      


Ala Asn Ser Gln Asp Gly Tyr Val Trp Gln Val Thr Asp Met Asn Arg 
            20                  25                  30          


Leu His Arg Phe Leu Cys Phe Gly Ser Glu Gly Gly Thr Tyr Tyr Ile 
        35                  40                  45              


Lys Glu Gln Lys Leu Gly Leu Glu Asn Ala Glu Ala Leu Ile Arg Leu 
    50                  55                  60                  


Ile Glu Asp Gly Arg Gly Cys Glu Val Ile Gln Glu Ile Lys Ser Phe 
65                  70                  75                  80  


Ser Gln Glu Gly Arg Thr Thr Lys Gln Glu Pro Met Leu Phe Ala Leu 
                85                  90                  95      


Ala Ile Cys Ser Gln Cys Ser Asp Ile Ser Thr Lys Gln Ala Ala Phe 
            100                 105                 110         


Lys Ala Val Ser Glu Val Cys Arg Ile Pro Thr His Leu Phe Thr Phe 
        115                 120                 125             


Ile Gln Phe Lys Lys Asp Leu Lys Glu Ser Met Lys Cys Gly Met Trp 
    130                 135                 140                 


Gly Arg Ala Leu Arg Lys Ala Ile Ala Asp Trp Tyr Asn Glu Lys Gly 
145                 150                 155                 160 


Gly Met Ala Leu Ala Leu Ala Val Thr Lys Tyr Lys Gln Arg Asn Gly 
                165                 170                 175     


Trp Ser His Lys Asp Leu Leu Arg Leu Ser His Leu Lys Pro Ser Ser 
            180                 185                 190         


Glu Gly Leu Ala Ile Val Thr Lys Tyr Ile Thr Lys Gly Trp Lys Glu 
        195                 200                 205             


Val His Glu Leu Tyr Lys Glu Lys Ala Leu Ser Val Glu Thr Glu Lys 
    210                 215                 220                 


Leu Leu Lys Tyr Leu Glu Ala Val Glu Lys Val Lys Arg Thr Arg Asp 
225                 230                 235                 240 


Glu Leu Glu Val Ile His Leu Ile Glu Glu His Arg Leu Val Arg Glu 
                245                 250                 255     


His Leu Leu Thr Asn His Leu Lys Ser Lys Glu Val Trp Lys Ala Leu 
            260                 265                 270         


Leu Gln Glu Met Pro Leu Thr Ala Leu Leu Arg Asn Leu Gly Lys Met 
        275                 280                 285             


Thr Ala Asn Ser Val Leu Glu Pro Gly Asn Ser Glu Val Ser Leu Val 
    290                 295                 300                 


Cys Glu Lys Leu Cys Asn Glu Lys Leu Leu Lys Lys Ala Arg Ile His 
305                 310                 315                 320 


Pro Phe His Ile Leu Ile Ala Leu Glu Thr Tyr Lys Thr Gly His Gly 
                325                 330                 335     


Leu Arg Gly Lys Leu Lys Trp Arg Pro Asp Glu Glu Ile Leu Lys Ala 
            340                 345                 350         


Leu Asp Ala Ala Phe Tyr Lys Thr Phe Lys Thr Val Glu Pro Thr Gly 
        355                 360                 365             


Lys Arg Phe Leu Leu Ala Val Asp Val Ser Ala Ser Met Asn Gln Arg 
    370                 375                 380                 


Val Leu Gly Ser Ile Leu Asn Ala Ser Thr Val Ala Ala Ala Met Cys 
385                 390                 395                 400 


Met Val Val Thr Arg Thr Glu Lys Asp Ser Tyr Val Val Ala Phe Ser 
                405                 410                 415     


Asp Glu Met Val Pro Cys Pro Val Thr Thr Asp Met Thr Leu Gln Gln 
            420                 425                 430         


Val Leu Met Ala Met Ser Gln Ile Pro Ala Gly Gly Thr Asp Cys Ser 
        435                 440                 445             


Leu Pro Met Ile Trp Ala Gln Lys Thr Asn Thr Pro Ala Asp Val Phe 
    450                 455                 460                 


Ile Val Phe Thr Asp Asn Glu Thr Phe Ala Gly Gly Val His Pro Ala 
465                 470                 475                 480 


Ile Ala Leu Arg Glu Tyr Arg Lys Lys Met Asp Ile Pro Ala Lys Leu 
                485                 490                 495     


Ile Val Cys Gly Met Thr Ser Asn Gly Phe Thr Ile Ala Asp Pro Asp 
            500                 505                 510         


Asp Arg Gly Met Leu Asp Met Cys Gly Phe Asp Thr Gly Ala Leu Asp 
        515                 520                 525             


Val Ile Arg Asn Phe Thr Leu Asp Met Ile 
    530                 535             


<210>  24
<211>  837
<212>  PRT
<213>  Escherichia coli

<400>  24

Met Ala Ser Lys Arg Lys Ser Thr Thr Pro Cys Met Val Arg Thr Ser 
1               5                   10                  15      


Gln Val Val Glu Gln Asp Val Pro Glu Glu Val Asp Arg Ala Lys Glu 
            20                  25                  30          


Lys Gly Ile Gly Thr Pro Gln Pro Asp Val Ala Lys Asp Ser Trp Ala 
        35                  40                  45              


Ala Glu Leu Glu Asn Ser Ser Lys Glu Asn Glu Val Ile Glu Val Lys 
    50                  55                  60                  


Ser Met Gly Glu Ser Gln Ser Lys Lys Leu Gln Gly Gly Tyr Glu Cys 
65                  70                  75                  80  


Lys Tyr Cys Pro Tyr Ser Thr Gln Asn Leu Asn Glu Phe Thr Glu His 
                85                  90                  95      


Val Asp Met Gln His Pro Asn Val Ile Leu Asn Pro Leu Tyr Val Cys 
            100                 105                 110         


Ala Glu Cys Asn Phe Thr Thr Lys Lys Tyr Asp Ser Leu Ser Asp His 
        115                 120                 125             


Asn Ser Lys Phe His Pro Gly Glu Ala Asn Phe Lys Leu Lys Leu Ile 
    130                 135                 140                 


Lys Arg Asn Asn Gln Thr Val Leu Glu Gln Ser Ile Glu Thr Thr Asn 
145                 150                 155                 160 


His Val Val Ser Ile Thr Thr Ser Gly Pro Gly Thr Gly Asp Ser Asp 
                165                 170                 175     


Ser Gly Ile Ser Val Ser Lys Thr Pro Ile Met Lys Pro Gly Lys Pro 
            180                 185                 190         


Lys Ala Asp Ala Lys Lys Val Pro Lys Lys Pro Glu Glu Ile Thr Pro 
        195                 200                 205             


Glu Asn His Val Glu Gly Thr Ala Arg Leu Val Thr Asp Thr Ala Glu 
    210                 215                 220                 


Ile Leu Ser Arg Leu Gly Gly Val Glu Leu Leu Gln Asp Thr Leu Gly 
225                 230                 235                 240 


His Val Met Pro Ser Val Gln Leu Pro Pro Asn Ile Asn Leu Val Pro 
                245                 250                 255     


Lys Val Pro Val Pro Leu Asn Thr Thr Lys Tyr Asn Ser Ala Leu Asp 
            260                 265                 270         


Thr Asn Ala Thr Met Ile Asn Ser Phe Asn Lys Phe Pro Tyr Pro Thr 
        275                 280                 285             


Gln Ala Glu Leu Ser Trp Leu Thr Ala Ala Ser Lys His Pro Glu Glu 
    290                 295                 300                 


His Ile Arg Ile Trp Phe Ala Thr Gln Arg Leu Lys His Gly Ile Ser 
305                 310                 315                 320 


Trp Ser Pro Glu Glu Val Glu Glu Ala Arg Lys Lys Met Phe Asn Gly 
                325                 330                 335     


Thr Ile Gln Ser Val Pro Pro Thr Ile Thr Val Leu Pro Ala Gln Leu 
            340                 345                 350         


Ala Pro Thr Lys Val Thr Gln Pro Ile Leu Gln Thr Ala Leu Pro Cys 
        355                 360                 365             


Gln Ile Leu Gly Gln Thr Ser Leu Val Leu Thr Gln Val Thr Ser Gly 
    370                 375                 380                 


Ser Thr Thr Val Ser Cys Ser Pro Ile Thr Leu Ala Val Ala Gly Val 
385                 390                 395                 400 


Thr Asn His Gly Gln Lys Arg Pro Leu Val Thr Pro Gln Ala Ala Pro 
                405                 410                 415     


Glu Pro Lys Arg Pro His Ile Ala Gln Val Pro Glu Pro Pro Pro Lys 
            420                 425                 430         


Val Ala Asn Pro Pro Leu Thr Pro Ala Ser Asp Arg Lys Lys Thr Lys 
        435                 440                 445             


Glu Gln Ile Ala His Leu Lys Ala Ser Phe Leu Gln Ser Gln Phe Pro 
    450                 455                 460                 


Asp Asp Ala Glu Val Tyr Arg Leu Ile Glu Val Thr Gly Leu Ala Arg 
465                 470                 475                 480 


Ser Glu Ile Lys Lys Trp Phe Ser Asp His Arg Tyr Arg Cys Gln Arg 
                485                 490                 495     


Gly Ile Val His Ile Thr Ser Glu Ser Leu Ala Lys Asp Gln Leu Ala 
            500                 505                 510         


Ile Ala Ala Ser Arg His Gly Arg Thr Tyr His Ala Tyr Pro Asp Phe 
        515                 520                 525             


Ala Pro Gln Lys Phe Lys Glu Lys Thr Gln Gly Gln Val Lys Ile Leu 
    530                 535                 540                 


Glu Asp Ser Phe Leu Lys Ser Ser Phe Pro Thr Gln Ala Glu Leu Asp 
545                 550                 555                 560 


Arg Leu Arg Val Glu Thr Lys Leu Ser Arg Arg Glu Ile Asp Ser Trp 
                565                 570                 575     


Phe Ser Glu Arg Arg Lys Leu Arg Asp Ser Met Glu Gln Ala Val Leu 
            580                 585                 590         


Asp Ser Met Gly Ser Gly Lys Lys Gly Gln Asp Val Gly Ala Pro Asn 
        595                 600                 605             


Gly Ala Leu Ser Arg Leu Asp Gln Leu Ser Gly Ala Gln Leu Thr Ser 
    610                 615                 620                 


Ser Leu Pro Ser Pro Ser Pro Ala Ile Ala Lys Ser Gln Glu Gln Val 
625                 630                 635                 640 


His Leu Leu Arg Ser Thr Phe Ala Arg Thr Gln Trp Pro Thr Pro Gln 
                645                 650                 655     


Glu Tyr Asp Gln Leu Ala Ala Lys Thr Gly Leu Val Arg Thr Glu Ile 
            660                 665                 670         


Val Arg Trp Phe Lys Glu Asn Arg Cys Leu Leu Lys Thr Gly Thr Val 
        675                 680                 685             


Lys Trp Met Glu Gln Tyr Gln His Gln Pro Met Ala Asp Asp His Gly 
    690                 695                 700                 


Tyr Asp Ala Val Ala Arg Lys Ala Thr Lys Pro Met Ala Glu Ser Pro 
705                 710                 715                 720 


Lys Asn Gly Gly Asp Val Val Pro Gln Tyr Tyr Lys Asp Pro Lys Lys 
                725                 730                 735     


Leu Cys Glu Glu Asp Leu Glu Lys Leu Val Thr Arg Val Lys Val Gly 
            740                 745                 750         


Ser Glu Pro Ala Lys Asp Cys Leu Pro Ala Lys Pro Ser Glu Ala Thr 
        755                 760                 765             


Ser Asp Arg Ser Glu Gly Ser Ser Arg Asp Gly Gln Gly Ser Asp Glu 
    770                 775                 780                 


Asn Glu Glu Ser Ser Val Val Asp Tyr Val Glu Val Thr Val Gly Glu 
785                 790                 795                 800 


Glu Asp Ala Ile Ser Asp Arg Ser Asp Ser Trp Ser Gln Ala Ala Ala 
                805                 810                 815     


Glu Gly Val Ser Glu Leu Ala Glu Ser Asp Ser Asp Cys Val Pro Ala 
            820                 825                 830         


Glu Ala Gly Gln Ala 
        835         


<210>  25
<211>  441
<212>  PRT
<213>  Escherichia coli

<400>  25

Met Glu Gln Pro Gln Glu Glu Ala Pro Glu Val Arg Glu Glu Glu Glu 
1               5                   10                  15      


Lys Glu Glu Val Ala Glu Ala Glu Gly Ala Pro Glu Leu Asn Gly Gly 
            20                  25                  30          


Pro Gln His Ala Leu Pro Ser Ser Ser Tyr Thr Asp Leu Ser Arg Ser 
        35                  40                  45              


Ser Ser Pro Pro Ser Leu Leu Asp Gln Leu Gln Met Gly Cys Asp Gly 
    50                  55                  60                  


Ala Ser Cys Gly Ser Leu Asn Met Glu Cys Arg Val Cys Gly Asp Lys 
65                  70                  75                  80  


Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly 
                85                  90                  95      


Phe Phe Arg Arg Thr Ile Arg Met Lys Leu Glu Tyr Glu Lys Cys Glu 
            100                 105                 110         


Arg Ser Cys Lys Ile Gln Lys Lys Asn Arg Asn Lys Cys Gln Tyr Cys 
        115                 120                 125             


Arg Phe Gln Lys Cys Leu Ala Leu Gly Met Ser His Asn Ala Ile Arg 
    130                 135                 140                 


Phe Gly Arg Met Pro Glu Ala Glu Lys Arg Lys Leu Val Ala Gly Leu 
145                 150                 155                 160 


Thr Ala Asn Glu Gly Ser Gln Tyr Asn Pro Gln Val Ala Asp Leu Lys 
                165                 170                 175     


Ala Phe Ser Lys His Ile Tyr Asn Ala Tyr Leu Lys Asn Phe Asn Met 
            180                 185                 190         


Thr Lys Lys Lys Ala Arg Ser Ile Leu Thr Gly Lys Ala Ser His Thr 
        195                 200                 205             


Ala Pro Phe Val Ile His Asp Ile Glu Thr Leu Trp Gln Ala Glu Lys 
    210                 215                 220                 


Gly Leu Val Trp Lys Gln Leu Val Asn Gly Leu Pro Pro Tyr Lys Glu 
225                 230                 235                 240 


Ile Ser Val His Val Phe Tyr Arg Cys Gln Cys Thr Thr Val Glu Thr 
                245                 250                 255     


Val Arg Glu Leu Thr Glu Phe Ala Lys Ser Ile Pro Ser Phe Ser Ser 
            260                 265                 270         


Leu Phe Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu 
        275                 280                 285             


Ala Ile Phe Ala Met Leu Ala Ser Ile Val Asn Lys Asp Gly Leu Leu 
    290                 295                 300                 


Val Ala Asn Gly Ser Gly Phe Val Thr Arg Glu Phe Leu Arg Ser Leu 
305                 310                 315                 320 


Arg Lys Pro Phe Ser Asp Ile Ile Glu Pro Lys Phe Glu Phe Ala Val 
                325                 330                 335     


Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Leu Phe Ile 
            340                 345                 350         


Ala Ala Ile Ile Leu Cys Gly Asp Arg Pro Gly Leu Met Asn Val Pro 
        355                 360                 365             


Arg Val Glu Ala Ile Gln Asp Thr Ile Leu Arg Ala Leu Glu Phe His 
    370                 375                 380                 


Leu Gln Ala Asn His Pro Asp Ala Gln Tyr Leu Phe Pro Lys Leu Leu 
385                 390                 395                 400 


Gln Lys Met Ala Asp Leu Arg Gln Leu Val Thr Glu His Ala Gln Met 
                405                 410                 415     


Met Gln Arg Ile Lys Lys Thr Glu Thr Glu Thr Ser Leu His Pro Leu 
            420                 425                 430         


Leu Gln Glu Ile Tyr Lys Asp Met Tyr 
        435                 440     


<210>  26
<211>  180
<212>  PRT
<213>  Escherichia coli

<400>  26

Met Glu Gln Pro Thr Ser Ser Thr Asn Gly Glu Lys Arg Lys Ser Pro 
1               5                   10                  15      


Cys Glu Ser Asn Asn Lys Lys Asn Asp Glu Met Gln Glu Ala Pro Asn 
            20                  25                  30          


Arg Val Leu Ala Pro Lys Gln Ser Leu Gln Lys Thr Lys Thr Ile Glu 
        35                  40                  45              


Tyr Leu Thr Ile Ile Val Tyr Tyr Tyr Arg Lys His Thr Lys Ile Asn 
    50                  55                  60                  


Ser Asn Gln Leu Glu Lys Asp Gln Ser Arg Glu Asn Ser Ile Asn Pro 
65                  70                  75                  80  


Val Gln Glu Glu Glu Asp Glu Gly Leu Asp Ser Ala Glu Gly Ser Ser 
                85                  90                  95      


Gln Glu Asp Glu Asp Leu Asp Ser Ser Glu Gly Ser Ser Gln Glu Asp 
            100                 105                 110         


Glu Asp Leu Asp Ser Ser Glu Gly Ser Ser Gln Glu Asp Glu Asp Leu 
        115                 120                 125             


Asp Ser Ser Glu Gly Ser Ser Gln Glu Asp Glu Asp Leu Asp Ser Ser 
    130                 135                 140                 


Glu Gly Ser Ser Gln Glu Asp Glu Asp Leu Asp Pro Pro Glu Gly Ser 
145                 150                 155                 160 


Ser Gln Glu Asp Glu Asp Leu Asp Ser Ser Glu Gly Ser Ser Gln Glu 
                165                 170                 175     


Gly Gly Glu Asp 
            180 


<210>  27
<211>  353
<212>  PRT
<213>  Escherichia coli

<400>  27

Met Glu Lys Thr Leu Glu Thr Val Pro Leu Glu Arg Lys Lys Arg Glu 
1               5                   10                  15      


Lys Glu Gln Phe Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr 
            20                  25                  30          


Thr Glu Glu Ser Leu Arg Asn Tyr Tyr Glu Gln Trp Gly Lys Leu Thr 
        35                  40                  45              


Asp Cys Val Val Met Arg Asp Pro Ala Ser Lys Arg Ser Arg Gly Phe 
    50                  55                  60                  


Gly Phe Val Thr Phe Ser Ser Met Ala Glu Val Asp Ala Ala Met Ala 
65                  70                  75                  80  


Ala Arg Pro His Ser Ile Asp Gly Arg Val Val Glu Pro Lys Arg Ala 
                85                  90                  95      


Val Ala Arg Glu Glu Ser Gly Lys Pro Gly Ala His Val Thr Val Lys 
            100                 105                 110         


Lys Leu Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu His His Leu 
        115                 120                 125             


Arg Asp Tyr Phe Glu Glu Tyr Gly Lys Ile Asp Thr Ile Glu Ile Ile 
    130                 135                 140                 


Thr Asp Arg Gln Ser Gly Lys Lys Arg Gly Phe Gly Phe Val Thr Phe 
145                 150                 155                 160 


Asp Asp His Asp Pro Val Asp Lys Ile Val Leu Gln Lys Tyr His Thr 
                165                 170                 175     


Ile Asn Gly His Asn Ala Glu Val Arg Lys Ala Leu Ser Arg Gln Glu 
            180                 185                 190         


Met Gln Glu Val Gln Ser Ser Arg Ser Gly Arg Gly Gly Asn Phe Gly 
        195                 200                 205             


Phe Gly Asp Ser Arg Gly Gly Gly Gly Asn Phe Gly Pro Gly Pro Gly 
    210                 215                 220                 


Ser Asn Phe Arg Gly Gly Ser Asp Gly Tyr Gly Ser Gly Arg Gly Phe 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Tyr Gly Gly Gly Pro Gly Gly Gly Asn Phe 
                245                 250                 255     


Gly Gly Ser Pro Gly Tyr Gly Gly Gly Arg Gly Gly Tyr Gly Gly Gly 
            260                 265                 270         


Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly Gly Gly Tyr Asp 
        275                 280                 285             


Asn Tyr Gly Gly Gly Asn Tyr Gly Ser Gly Asn Tyr Asn Asp Phe Gly 
    290                 295                 300                 


Asn Tyr Asn Gln Gln Pro Ser Asn Tyr Gly Pro Met Lys Ser Gly Asn 
305                 310                 315                 320 


Phe Gly Gly Ser Arg Asn Met Gly Gly Pro Tyr Gly Gly Gly Asn Tyr 
                325                 330                 335     


Gly Pro Gly Gly Ser Gly Gly Ser Gly Gly Tyr Gly Gly Arg Ser Arg 
            340                 345                 350         


Tyr 
    


<210>  28
<211>  343
<212>  PRT
<213>  Escherichia coli

<400>  28

Met Asn Ile His Arg Ser Thr Pro Ile Thr Ile Ala Arg Tyr Gly Arg 
1               5                   10                  15      


Ser Arg Asn Lys Thr Gln Asp Phe Glu Glu Leu Ser Ser Ile Arg Ser 
            20                  25                  30          


Ala Glu Pro Ser Gln Ser Phe Ser Pro Asn Leu Gly Ser Pro Ser Pro 
        35                  40                  45              


Pro Glu Thr Pro Asn Leu Ser His Cys Val Ser Cys Ile Gly Lys Tyr 
    50                  55                  60                  


Leu Leu Leu Glu Pro Leu Glu Gly Asp His Val Phe Arg Ala Val His 
65                  70                  75                  80  


Leu His Ser Gly Glu Glu Leu Val Cys Lys Val Phe Asp Ile Ser Cys 
                85                  90                  95      


Tyr Gln Glu Ser Leu Ala Pro Cys Phe Cys Leu Ser Ala His Ser Asn 
            100                 105                 110         


Ile Asn Gln Ile Thr Glu Ile Ile Leu Gly Glu Thr Lys Ala Tyr Val 
        115                 120                 125             


Phe Phe Glu Arg Ser Tyr Gly Asp Met His Ser Phe Val Arg Thr Cys 
    130                 135                 140                 


Lys Lys Leu Arg Glu Glu Glu Ala Ala Arg Leu Phe Tyr Gln Ile Ala 
145                 150                 155                 160 


Ser Ala Val Ala His Cys His Asp Gly Gly Leu Val Leu Arg Asp Leu 
                165                 170                 175     


Lys Leu Arg Lys Phe Ile Phe Lys Asp Glu Glu Arg Thr Arg Val Lys 
            180                 185                 190         


Leu Glu Ser Leu Glu Asp Ala Tyr Ile Leu Arg Gly Asp Asp Asp Ser 
        195                 200                 205             


Leu Ser Asp Lys His Gly Cys Pro Ala Tyr Val Ser Pro Glu Ile Leu 
    210                 215                 220                 


Asn Thr Ser Gly Ser Tyr Ser Gly Lys Ala Ala Asp Val Trp Ser Leu 
225                 230                 235                 240 


Gly Val Met Leu Tyr Thr Met Leu Val Gly Arg Tyr Pro Phe His Asp 
                245                 250                 255     


Ile Glu Pro Ser Ser Leu Phe Ser Lys Ile Arg Arg Gly Gln Phe Asn 
            260                 265                 270         


Ile Pro Glu Thr Leu Ser Pro Lys Ala Lys Cys Leu Ile Arg Ser Ile 
        275                 280                 285             


Leu Arg Arg Glu Pro Ser Glu Arg Leu Thr Ser Gln Glu Ile Leu Asp 
    290                 295                 300                 


His Pro Trp Phe Ser Thr Asp Phe Ser Val Ser Asn Ser Ala Tyr Gly 
305                 310                 315                 320 


Ala Lys Glu Val Ser Asp Gln Leu Val Pro Asp Val Asn Met Glu Glu 
                325                 330                 335     


Asn Leu Asp Pro Phe Phe Asn 
            340             


<210>  29
<211>  464
<212>  PRT
<213>  Escherichia coli

<400>  29

Met Ser Ser Arg Ser Thr Lys Asp Leu Ile Lys Ser Lys Trp Gly Ser 
1               5                   10                  15      


Lys Pro Ser Asn Ser Lys Ser Glu Thr Thr Leu Glu Lys Leu Lys Gly 
            20                  25                  30          


Glu Ile Ala His Leu Lys Thr Ser Val Asp Glu Ile Thr Ser Gly Lys 
        35                  40                  45              


Gly Lys Leu Thr Asp Lys Glu Arg His Arg Leu Leu Glu Lys Ile Arg 
    50                  55                  60                  


Val Leu Glu Ala Glu Lys Glu Lys Asn Ala Tyr Gln Leu Thr Glu Lys 
65                  70                  75                  80  


Asp Lys Glu Ile Gln Arg Leu Arg Asp Gln Leu Lys Ala Arg Tyr Ser 
                85                  90                  95      


Thr Thr Thr Leu Leu Glu Gln Leu Glu Glu Thr Thr Arg Glu Gly Glu 
            100                 105                 110         


Arg Arg Glu Gln Val Leu Lys Ala Leu Ser Glu Glu Lys Asp Val Leu 
        115                 120                 125             


Lys Gln Gln Leu Ser Ala Ala Thr Ser Arg Ile Ala Glu Leu Glu Ser 
    130                 135                 140                 


Lys Thr Asn Thr Leu Arg Leu Ser Gln Thr Val Ala Pro Asn Cys Phe 
145                 150                 155                 160 


Asn Ser Ser Ile Asn Asn Ile His Glu Met Glu Ile Gln Leu Lys Asp 
                165                 170                 175     


Ala Leu Glu Lys Asn Gln Gln Trp Leu Val Tyr Asp Gln Gln Arg Glu 
            180                 185                 190         


Val Tyr Val Lys Gly Leu Leu Ala Lys Ile Phe Glu Leu Glu Lys Lys 
        195                 200                 205             


Thr Glu Thr Ala Ala His Ser Leu Pro Gln Gln Thr Lys Lys Pro Glu 
    210                 215                 220                 


Ser Glu Gly Tyr Leu Gln Glu Glu Lys Gln Lys Cys Tyr Asn Asp Leu 
225                 230                 235                 240 


Leu Ala Ser Ala Lys Lys Asp Leu Glu Val Glu Arg Gln Thr Ile Thr 
                245                 250                 255     


Gln Leu Ser Phe Glu Leu Ser Glu Phe Arg Arg Lys Tyr Glu Glu Thr 
            260                 265                 270         


Gln Lys Glu Val His Asn Leu Asn Gln Leu Leu Tyr Ser Gln Arg Arg 
        275                 280                 285             


Ala Asp Val Gln His Leu Glu Asp Asp Arg His Lys Thr Glu Lys Ile 
    290                 295                 300                 


Gln Lys Leu Arg Glu Glu Asn Asp Ile Ala Arg Gly Lys Leu Glu Glu 
305                 310                 315                 320 


Glu Lys Lys Arg Ser Glu Glu Leu Leu Ser Gln Val Gln Phe Leu Tyr 
                325                 330                 335     


Thr Ser Leu Leu Lys Gln Gln Glu Glu Gln Thr Arg Val Ala Leu Leu 
            340                 345                 350         


Glu Gln Gln Met Gln Ala Cys Thr Leu Asp Phe Glu Asn Glu Lys Leu 
        355                 360                 365             


Asp Arg Gln His Val Gln His Gln Leu His Val Ile Leu Lys Glu Leu 
    370                 375                 380                 


Arg Lys Ala Arg Asn Gln Ile Thr Gln Leu Glu Ser Leu Lys Gln Leu 
385                 390                 395                 400 


His Glu Phe Ala Ile Thr Glu Pro Leu Val Thr Phe Gln Gly Glu Thr 
                405                 410                 415     


Glu Asn Arg Glu Lys Val Ala Ala Ser Pro Lys Ser Pro Thr Ala Ala 
            420                 425                 430         


Leu Asn Glu Ser Leu Val Glu Cys Pro Lys Cys Asn Ile Gln Tyr Pro 
        435                 440                 445             


Ala Thr Glu His Arg Asp Leu Leu Val His Val Glu Tyr Cys Ser Lys 
    450                 455                 460                 


<210>  30
<211>  368
<212>  PRT
<213>  Escherichia coli

<400>  30

Met Ser Val Ala Gly Leu Lys Lys Gln Phe Tyr Lys Ala Ser Gln Leu 
1               5                   10                  15      


Val Ser Glu Lys Val Gly Gly Ala Glu Gly Thr Lys Leu Asp Asp Asp 
            20                  25                  30          


Phe Lys Glu Met Glu Lys Lys Val Asp Val Thr Ser Lys Ala Val Thr 
        35                  40                  45              


Glu Val Leu Ala Arg Thr Ile Glu Tyr Leu Gln Pro Asn Pro Ala Ser 
    50                  55                  60                  


Arg Ala Lys Leu Thr Met Leu Asn Thr Val Ser Lys Ile Arg Gly Gln 
65                  70                  75                  80  


Val Lys Asn Pro Gly Tyr Pro Gln Ser Glu Gly Leu Leu Gly Glu Cys 
                85                  90                  95      


Met Ile Arg His Gly Lys Glu Leu Gly Gly Glu Ser Asn Phe Gly Asp 
            100                 105                 110         


Ala Leu Leu Asp Ala Gly Glu Ser Met Lys Arg Leu Ala Glu Val Lys 
        115                 120                 125             


Asp Ser Leu Asp Ile Glu Val Lys Gln Asn Phe Ile Asp Pro Leu Gln 
    130                 135                 140                 


Asn Leu Cys Glu Lys Asp Leu Lys Glu Ile Gln His His Leu Lys Lys 
145                 150                 155                 160 


Leu Glu Gly Arg Arg Leu Asp Phe Asp Tyr Lys Lys Lys Arg Gln Gly 
                165                 170                 175     


Lys Ile Pro Asp Glu Glu Leu Arg Gln Ala Leu Glu Lys Phe Glu Glu 
            180                 185                 190         


Ser Lys Glu Val Ala Glu Thr Ser Met His Asn Leu Leu Glu Thr Asp 
        195                 200                 205             


Ile Glu Gln Val Ser Gln Leu Ser Ala Leu Val Asp Ala Gln Leu Asp 
    210                 215                 220                 


Tyr His Arg Gln Ala Val Gln Ile Leu Asp Glu Leu Ala Glu Lys Leu 
225                 230                 235                 240 


Lys Arg Arg Met Arg Glu Ala Ser Ser Arg Pro Lys Arg Glu Tyr Lys 
                245                 250                 255     


Pro Lys Pro Arg Glu Pro Phe Asp Leu Gly Glu Pro Glu Gln Ser Asn 
            260                 265                 270         


Gly Gly Phe Pro Cys Thr Thr Ala Pro Lys Ile Ala Ala Ser Ser Ser 
        275                 280                 285             


Phe Arg Ser Ser Asp Lys Pro Ile Arg Thr Pro Ser Arg Ser Met Pro 
    290                 295                 300                 


Pro Leu Asp Gln Pro Ser Cys Lys Ala Leu Tyr Asp Phe Glu Pro Glu 
305                 310                 315                 320 


Asn Asp Gly Glu Leu Gly Phe His Glu Gly Asp Val Ile Thr Leu Thr 
                325                 330                 335     


Asn Gln Ile Asp Glu Asn Trp Tyr Glu Gly Met Leu Asp Gly Gln Ser 
            340                 345                 350         


Gly Phe Phe Pro Leu Ser Tyr Val Glu Val Leu Val Pro Leu Pro Gln 
        355                 360                 365             


<210>  31
<211>  309
<212>  PRT
<213>  Escherichia coli

<400>  31

Met Glu Gln Leu Leu Arg Ala Glu Leu Arg Thr Ala Thr Leu Arg Ala 
1               5                   10                  15      


Phe Gly Gly Pro Gly Ala Gly Cys Ile Ser Glu Gly Arg Ala Tyr Asp 
            20                  25                  30          


Thr Asp Ala Gly Pro Val Phe Val Lys Val Asn Arg Arg Thr Gln Ala 
        35                  40                  45              


Arg Gln Met Phe Glu Gly Glu Val Ala Ser Leu Glu Ala Leu Arg Ser 
    50                  55                  60                  


Thr Gly Leu Val Arg Val Pro Arg Pro Met Lys Val Ile Asp Leu Pro 
65                  70                  75                  80  


Gly Gly Gly Ala Ala Phe Val Met Glu His Leu Lys Met Lys Ser Leu 
                85                  90                  95      


Ser Ser Gln Ala Ser Lys Leu Gly Glu Gln Met Ala Asp Leu His Leu 
            100                 105                 110         


Tyr Asn Gln Lys Leu Arg Glu Lys Leu Lys Glu Glu Glu Asn Thr Val 
        115                 120                 125             


Gly Arg Arg Gly Glu Gly Ala Glu Pro Gln Tyr Val Asp Lys Phe Gly 
    130                 135                 140                 


Phe His Thr Val Thr Cys Cys Gly Phe Ile Pro Gln Val Asn Glu Trp 
145                 150                 155                 160 


Gln Asp Asp Trp Pro Thr Phe Phe Ala Arg His Arg Leu Gln Ala Gln 
                165                 170                 175     


Leu Asp Leu Ile Glu Lys Asp Tyr Ala Asp Arg Glu Ala Arg Glu Leu 
            180                 185                 190         


Trp Ser Arg Leu Gln Val Lys Ile Pro Asp Leu Phe Cys Gly Leu Glu 
        195                 200                 205             


Ile Val Pro Ala Leu Leu His Gly Asp Leu Trp Ser Gly Asn Val Ala 
    210                 215                 220                 


Glu Asp Asp Val Gly Pro Ile Ile Tyr Asp Pro Ala Ser Phe Tyr Gly 
225                 230                 235                 240 


His Ser Glu Phe Glu Leu Ala Ile Ala Leu Met Phe Gly Gly Phe Pro 
                245                 250                 255     


Arg Ser Phe Phe Thr Ala Tyr His Arg Lys Ile Pro Lys Ala Pro Gly 
            260                 265                 270         


Phe Asp Gln Arg Leu Leu Leu Tyr Gln Leu Phe Asn Tyr Leu Asn His 
        275                 280                 285             


Trp Asn His Phe Gly Arg Glu Tyr Arg Ser Pro Ser Leu Gly Thr Met 
    290                 295                 300                 


Arg Arg Leu Leu Lys 
305                 


<210>  32
<211>  370
<212>  PRT
<213>  Escherichia coli

<400>  32

Met Lys Ile Lys Asp Ala Lys Lys Pro Ser Phe Pro Trp Phe Gly Met 
1               5                   10                  15      


Asp Ile Gly Gly Thr Leu Val Lys Leu Ser Tyr Phe Glu Pro Ile Asp 
            20                  25                  30          


Ile Thr Ala Glu Glu Glu Gln Glu Glu Val Glu Ser Leu Lys Ser Ile 
        35                  40                  45              


Arg Lys Tyr Leu Thr Ser Asn Val Ala Tyr Gly Ser Thr Gly Ile Arg 
    50                  55                  60                  


Asp Val His Leu Glu Leu Lys Asp Leu Thr Leu Phe Gly Arg Arg Gly 
65                  70                  75                  80  


Asn Leu His Phe Ile Arg Phe Pro Thr Gln Asp Leu Pro Thr Phe Ile 
                85                  90                  95      


Gln Met Gly Arg Asp Lys Asn Phe Ser Thr Leu Gln Thr Val Leu Cys 
            100                 105                 110         


Ala Thr Gly Gly Gly Ala Tyr Lys Phe Glu Lys Asp Phe Arg Thr Ile 
        115                 120                 125             


Gly Asn Leu His Leu His Lys Leu Asp Glu Leu Asp Cys Leu Val Lys 
    130                 135                 140                 


Gly Leu Leu Tyr Ile Asp Ser Val Ser Phe Asn Gly Gln Ala Glu Cys 
145                 150                 155                 160 


Tyr Tyr Phe Ala Asn Ala Ser Glu Pro Glu Arg Cys Gln Lys Met Pro 
                165                 170                 175     


Phe Asn Leu Asp Asp Pro Tyr Pro Leu Leu Val Val Asn Ile Gly Ser 
            180                 185                 190         


Gly Val Ser Ile Leu Ala Val His Ser Lys Asp Asn Tyr Lys Arg Val 
        195                 200                 205             


Thr Gly Thr Ser Leu Gly Gly Gly Thr Phe Leu Gly Leu Cys Ser Leu 
    210                 215                 220                 


Leu Thr Gly Cys Glu Ser Phe Glu Glu Ala Leu Glu Met Ala Ser Lys 
225                 230                 235                 240 


Gly Asp Ser Thr Gln Ala Asp Lys Leu Val Arg Asp Ile Tyr Gly Gly 
                245                 250                 255     


Asp Tyr Glu Arg Phe Gly Leu Pro Gly Trp Ala Val Ala Ser Ser Phe 
            260                 265                 270         


Gly Asn Met Ile Tyr Lys Glu Lys Arg Glu Ser Val Ser Lys Glu Asp 
        275                 280                 285             


Leu Ala Arg Ala Thr Leu Val Thr Ile Thr Asn Asn Ile Gly Ser Val 
    290                 295                 300                 


Ala Arg Met Cys Ala Val Asn Glu Lys Ile Asn Arg Val Val Phe Val 
305                 310                 315                 320 


Gly Asn Phe Leu Arg Val Asn Thr Leu Ser Met Lys Leu Leu Ala Tyr 
                325                 330                 335     


Ala Leu Asp Tyr Trp Ser Lys Gly Gln Leu Lys Ala Leu Phe Leu Glu 
            340                 345                 350         


His Glu Gly Tyr Phe Gly Ala Val Gly Ala Leu Leu Gly Leu Pro Asn 
        355                 360                 365             


Phe Ser 
    370 


<210>  33
<211>  193
<212>  PRT
<213>  Escherichia coli

<400>  33

Met Gly Lys Gln Asn Ser Lys Leu Arg Pro Glu Val Leu Gln Asp Leu 
1               5                   10                  15      


Arg Glu Asn Thr Glu Phe Thr Asp His Glu Leu Gln Glu Trp Tyr Lys 
            20                  25                  30          


Gly Phe Leu Lys Asp Cys Pro Thr Gly His Leu Thr Val Asp Glu Phe 
        35                  40                  45              


Lys Lys Ile Tyr Ala Asn Phe Phe Pro Tyr Gly Asp Ala Ser Lys Phe 
    50                  55                  60                  


Ala Glu His Val Phe Arg Thr Phe Asp Thr Asn Gly Asp Gly Thr Ile 
65                  70                  75                  80  


Asp Phe Arg Glu Phe Ile Ile Ala Leu Ser Val Thr Ser Arg Gly Lys 
                85                  90                  95      


Leu Glu Gln Lys Leu Lys Trp Ala Phe Ser Met Tyr Asp Leu Asp Gly 
            100                 105                 110         


Asn Gly Tyr Ile Ser Arg Ser Glu Met Leu Glu Ile Val Gln Ala Ile 
        115                 120                 125             


Tyr Lys Met Val Ser Ser Val Met Lys Met Pro Glu Asp Glu Ser Thr 
    130                 135                 140                 


Pro Glu Lys Arg Thr Asp Lys Ile Phe Arg Gln Met Asp Thr Asn Asn 
145                 150                 155                 160 


Asp Gly Lys Leu Ser Leu Glu Glu Phe Ile Arg Gly Ala Lys Ser Asp 
                165                 170                 175     


Pro Ser Ile Val Arg Leu Leu Gln Cys Asp Pro Ser Ser Ala Ser Gln 
            180                 185                 190         


Phe 
    


<210>  34
<211>  490
<212>  PRT
<213>  Escherichia coli

<400>  34

Met Glu Gln Lys Pro Ser Lys Val Glu Cys Gly Ser Asp Pro Glu Glu 
1               5                   10                  15      


Asn Ser Ala Arg Ser Pro Asp Gly Lys Arg Lys Arg Lys Asn Gly Gln 
            20                  25                  30          


Cys Ser Leu Lys Thr Ser Met Ser Gly Tyr Ile Pro Ser Tyr Leu Asp 
        35                  40                  45              


Lys Asp Glu Gln Cys Val Val Cys Gly Asp Lys Ala Thr Gly Tyr His 
    50                  55                  60                  


Tyr Arg Cys Ile Thr Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Thr 
65                  70                  75                  80  


Ile Gln Lys Asn Leu His Pro Thr Tyr Ser Cys Lys Tyr Asp Ser Cys 
                85                  90                  95      


Cys Val Ile Asp Lys Ile Thr Arg Asn Gln Cys Gln Leu Cys Arg Phe 
            100                 105                 110         


Lys Lys Cys Ile Ala Val Gly Met Ala Met Asp Leu Val Leu Asp Asp 
        115                 120                 125             


Ser Lys Arg Val Ala Lys Arg Lys Leu Ile Glu Gln Asn Arg Glu Arg 
    130                 135                 140                 


Arg Arg Lys Glu Glu Met Ile Arg Ser Leu Gln Gln Arg Pro Glu Pro 
145                 150                 155                 160 


Thr Pro Glu Glu Trp Asp Leu Ile His Ile Ala Thr Glu Ala His Arg 
                165                 170                 175     


Ser Thr Asn Ala Gln Gly Ser His Trp Lys Gln Arg Arg Lys Phe Leu 
            180                 185                 190         


Pro Asp Asp Ile Gly Gln Ser Pro Ile Val Ser Met Pro Asp Gly Asp 
        195                 200                 205             


Lys Val Asp Leu Glu Ala Phe Ser Glu Phe Thr Lys Ile Ile Thr Pro 
    210                 215                 220                 


Ala Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Ser 
225                 230                 235                 240 


Glu Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met 
                245                 250                 255     


Glu Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Asp 
            260                 265                 270         


Thr Leu Thr Leu Ser Gly Glu Met Ala Val Lys Arg Glu Gln Leu Lys 
        275                 280                 285             


Asn Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Glu Leu Gly Lys 
    290                 295                 300                 


Ser Leu Ser Ala Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln 
305                 310                 315                 320 


Ala Val Leu Leu Met Ser Thr Asp Arg Ser Gly Leu Leu Cys Val Asp 
                325                 330                 335     


Lys Ile Glu Lys Ser Gln Glu Ala Tyr Leu Leu Ala Phe Glu His Tyr 
            340                 345                 350         


Val Asn His Arg Lys His Asn Ile Pro His Phe Trp Pro Lys Leu Leu 
        355                 360                 365             


Met Lys Glu Arg Glu Val Gln Ser Ser Ile Leu Tyr Lys Gly Ala Ala 
    370                 375                 380                 


Ala Glu Gly Arg Pro Gly Gly Ser Leu Gly Val His Pro Glu Gly Gln 
385                 390                 395                 400 


Gln Leu Leu Gly Met His Val Val Gln Gly Pro Gln Val Arg Gln Leu 
                405                 410                 415     


Glu Gln Gln Leu Gly Glu Ala Gly Ser Leu Gln Gly Pro Val Leu Gln 
            420                 425                 430         


His Gln Ser Pro Lys Ser Pro Gln Gln Arg Leu Leu Glu Leu Leu His 
        435                 440                 445             


Arg Ser Gly Ile Leu His Ala Arg Ala Val Cys Gly Glu Asp Asp Ser 
    450                 455                 460                 


Ser Glu Ala Asp Ser Pro Ser Ser Ser Glu Glu Glu Pro Glu Val Cys 
465                 470                 475                 480 


Glu Asp Leu Ala Gly Asn Ala Ala Ser Pro 
                485                 490 


<210>  35
<211>  613
<212>  PRT
<213>  Escherichia coli

<400>  35

Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu 
1               5                   10                  15      


Val Pro Leu Val Arg Thr Val Cys Val Arg Ser Pro Arg Gln Arg Asn 
            20                  25                  30          


Arg Leu Pro Gly Asn Leu Phe Gln Arg Trp His Val Pro Leu Glu Leu 
        35                  40                  45              


Gln Met Thr Arg Gln Met Ala Ser Ser Gly Ala Ser Gly Gly Lys Ile 
    50                  55                  60                  


Asp Asn Ser Val Leu Val Leu Ile Val Gly Leu Ser Thr Val Gly Ala 
65                  70                  75                  80  


Gly Ala Tyr Ala Tyr Lys Thr Met Lys Glu Asp Glu Lys Arg Tyr Asn 
                85                  90                  95      


Glu Arg Ile Ser Gly Leu Gly Leu Thr Pro Glu Gln Lys Gln Lys Lys 
            100                 105                 110         


Ala Ala Leu Ser Ala Ser Glu Gly Glu Glu Val Pro Gln Asp Lys Ala 
        115                 120                 125             


Pro Ser His Val Pro Phe Leu Leu Ile Gly Gly Gly Thr Ala Ala Phe 
    130                 135                 140                 


Ala Ala Ala Arg Ser Ile Arg Ala Arg Asp Pro Gly Ala Arg Val Leu 
145                 150                 155                 160 


Ile Val Ser Glu Asp Pro Glu Leu Pro Tyr Met Arg Pro Pro Leu Ser 
                165                 170                 175     


Lys Glu Leu Trp Phe Ser Asp Asp Pro Asn Val Thr Lys Thr Leu Arg 
            180                 185                 190         


Phe Lys Gln Trp Asn Gly Lys Glu Arg Ser Ile Tyr Phe Gln Pro Pro 
        195                 200                 205             


Ser Phe Tyr Val Ser Ala Gln Asp Leu Pro His Ile Glu Asn Gly Gly 
    210                 215                 220                 


Val Ala Val Leu Thr Gly Lys Lys Val Val Gln Leu Asp Val Arg Asp 
225                 230                 235                 240 


Asn Met Val Lys Leu Asn Asp Gly Ser Gln Ile Thr Tyr Glu Lys Cys 
                245                 250                 255     


Leu Ile Ala Thr Gly Gly Thr Pro Arg Ser Leu Ser Ala Ile Asp Arg 
            260                 265                 270         


Ala Gly Ala Glu Val Lys Ser Arg Thr Thr Leu Phe Arg Lys Ile Gly 
        275                 280                 285             


Asp Phe Arg Ser Leu Glu Lys Ile Ser Arg Glu Val Lys Ser Ile Thr 
    290                 295                 300                 


Ile Ile Gly Gly Gly Phe Leu Gly Ser Glu Leu Ala Cys Ala Leu Gly 
305                 310                 315                 320 


Arg Lys Ala Arg Ala Leu Gly Thr Glu Val Ile Gln Leu Phe Pro Glu 
                325                 330                 335     


Lys Gly Asn Met Gly Lys Ile Leu Pro Glu Tyr Leu Ser Asn Trp Thr 
            340                 345                 350         


Met Glu Lys Val Arg Arg Glu Gly Val Lys Val Met Pro Asn Ala Ile 
        355                 360                 365             


Val Gln Ser Val Gly Val Ser Ser Gly Lys Leu Leu Ile Lys Leu Lys 
    370                 375                 380                 


Asp Gly Arg Lys Val Glu Thr Asp His Ile Val Ala Ala Val Gly Leu 
385                 390                 395                 400 


Glu Pro Asn Val Glu Leu Ala Lys Thr Gly Gly Leu Glu Ile Asp Ser 
                405                 410                 415     


Asp Phe Gly Gly Phe Arg Val Asn Ala Glu Leu Gln Ala Arg Ser Asn 
            420                 425                 430         


Ile Trp Val Ala Gly Asp Ala Ala Cys Phe Tyr Asp Ile Lys Leu Gly 
        435                 440                 445             


Arg Arg Arg Val Glu His His Asp His Ala Val Val Ser Gly Arg Leu 
    450                 455                 460                 


Ala Gly Glu Asn Met Thr Gly Ala Ala Lys Pro Tyr Trp His Gln Ser 
465                 470                 475                 480 


Met Phe Trp Ser Asp Leu Gly Pro Asp Val Gly Tyr Glu Ala Ile Gly 
                485                 490                 495     


Leu Val Asp Ser Ser Leu Pro Thr Val Gly Val Phe Ala Lys Ala Thr 
            500                 505                 510         


Ala Gln Asp Asn Pro Lys Ser Ala Thr Glu Gln Ser Gly Thr Gly Ile 
        515                 520                 525             


Arg Ser Glu Ser Glu Thr Glu Ser Glu Ala Ser Glu Ile Thr Ile Pro 
    530                 535                 540                 


Pro Ser Thr Pro Ala Val Pro Gln Ala Pro Val Gln Gly Glu Asp Tyr 
545                 550                 555                 560 


Gly Lys Gly Val Ile Phe Tyr Leu Arg Asp Lys Val Val Val Gly Ile 
                565                 570                 575     


Val Leu Trp Asn Ile Phe Asn Arg Met Pro Ile Ala Arg Lys Ile Ile 
            580                 585                 590         


Lys Asp Gly Glu Gln His Glu Asp Leu Asn Glu Val Ala Lys Leu Phe 
        595                 600                 605             


Asn Ile His Glu Asp 
    610             


<210>  36
<211>  461
<212>  PRT
<213>  Escherichia coli

<400>  36

Met Asn Asn Phe Gly Asn Glu Glu Phe Asp Cys His Phe Leu Asp Glu 
1               5                   10                  15      


Gly Phe Thr Ala Lys Asp Ile Leu Asp Gln Lys Ile Asn Glu Val Ser 
            20                  25                  30          


Ser Ser Asp Asp Lys Asp Ala Phe Tyr Val Ala Asp Leu Gly Asp Ile 
        35                  40                  45              


Leu Lys Lys His Leu Arg Trp Leu Lys Ala Leu Pro Arg Val Thr Pro 
    50                  55                  60                  


Phe Tyr Ala Val Lys Cys Asn Asp Ser Lys Ala Ile Val Lys Thr Leu 
65                  70                  75                  80  


Ala Ala Thr Gly Thr Gly Phe Asp Cys Ala Ser Lys Thr Glu Ile Gln 
                85                  90                  95      


Leu Val Gln Ser Leu Gly Val Pro Pro Glu Arg Ile Ile Tyr Ala Asn 
            100                 105                 110         


Pro Cys Lys Gln Val Ser Gln Ile Lys Tyr Ala Ala Asn Asn Gly Val 
        115                 120                 125             


Gln Met Met Thr Phe Asp Ser Glu Val Glu Leu Met Lys Val Ala Arg 
    130                 135                 140                 


Ala His Pro Lys Ala Lys Leu Val Leu Arg Ile Ala Thr Asp Asp Ser 
145                 150                 155                 160 


Lys Ala Val Cys Arg Leu Ser Val Lys Phe Gly Ala Thr Leu Arg Thr 
                165                 170                 175     


Ser Arg Leu Leu Leu Glu Arg Ala Lys Glu Leu Asn Ile Asp Val Val 
            180                 185                 190         


Gly Val Ser Phe His Val Gly Ser Gly Cys Thr Asp Pro Glu Thr Phe 
        195                 200                 205             


Val Gln Ala Ile Ser Asp Ala Arg Cys Val Phe Asp Met Gly Ala Glu 
    210                 215                 220                 


Val Gly Phe Ser Met Tyr Leu Leu Asp Ile Gly Gly Gly Phe Pro Gly 
225                 230                 235                 240 


Ser Glu Asp Val Lys Leu Lys Phe Glu Glu Ile Thr Gly Val Ile Asn 
                245                 250                 255     


Pro Ala Leu Asp Lys Tyr Phe Pro Ser Asp Ser Gly Val Arg Ile Ile 
            260                 265                 270         


Ala Glu Pro Gly Arg Tyr Tyr Val Ala Ser Ala Phe Thr Leu Ala Val 
        275                 280                 285             


Asn Ile Ile Ala Lys Lys Ile Val Leu Lys Glu Gln Thr Gly Ser Asp 
    290                 295                 300                 


Asp Glu Asp Glu Ser Ser Glu Gln Thr Phe Met Tyr Tyr Val Asn Asp 
305                 310                 315                 320 


Gly Val Tyr Gly Ser Phe Asn Cys Ile Leu Tyr Asp His Ala His Val 
                325                 330                 335     


Lys Pro Leu Leu Gln Lys Arg Pro Lys Pro Asp Glu Lys Tyr Tyr Ser 
            340                 345                 350         


Ser Ser Ile Trp Gly Pro Thr Cys Asp Gly Leu Asp Arg Ile Val Glu 
        355                 360                 365             


Arg Cys Asp Leu Pro Glu Met His Val Gly Asp Trp Met Leu Phe Glu 
    370                 375                 380                 


Asn Met Gly Ala Tyr Thr Val Ala Ala Ala Ser Thr Phe Asn Gly Phe 
385                 390                 395                 400 


Gln Arg Pro Thr Ile Tyr Tyr Val Met Ser Gly Pro Ala Trp Gln Leu 
                405                 410                 415     


Met Gln Gln Phe Gln Asn Pro Asp Phe Pro Pro Glu Val Glu Glu Gln 
            420                 425                 430         


Asp Ala Ser Thr Leu Pro Val Ser Cys Ala Trp Glu Ser Gly Met Lys 
        435                 440                 445             


Arg His Arg Ala Ala Cys Ala Ser Ala Ser Ile Asn Val 
    450                 455                 460     


<210>  37
<211>  772
<212>  PRT
<213>  Escherichia coli

<400>  37

Met Gly Asp Glu Asp Asp Asp Glu Ser Cys Ala Val Glu Leu Arg Ile 
1               5                   10                  15      


Thr Glu Ala Asn Leu Thr Gly His Glu Glu Lys Val Ser Val Glu Asn 
            20                  25                  30          


Phe Glu Leu Leu Lys Val Leu Gly Thr Gly Ala Tyr Gly Lys Val Phe 
        35                  40                  45              


Leu Val Arg Lys Ala Gly Gly His Asp Ala Gly Lys Leu Tyr Ala Met 
    50                  55                  60                  


Lys Val Leu Arg Lys Ala Ala Leu Val Gln Arg Ala Lys Thr Gln Glu 
65                  70                  75                  80  


His Thr Arg Thr Glu Arg Ser Val Leu Glu Leu Val Arg Gln Ala Pro 
                85                  90                  95      


Phe Leu Val Thr Leu His Tyr Ala Phe Gln Thr Asp Ala Lys Leu His 
            100                 105                 110         


Leu Ile Leu Asp Tyr Val Ser Gly Gly Glu Met Phe Thr His Leu Tyr 
        115                 120                 125             


Gln Arg Gln Tyr Phe Lys Glu Ala Glu Val Arg Val Tyr Gly Gly Glu 
    130                 135                 140                 


Ile Val Leu Ala Leu Glu His Leu His Lys Leu Gly Ile Ile Tyr Arg 
145                 150                 155                 160 


Asp Leu Lys Leu Glu Asn Val Leu Leu Asp Ser Glu Gly His Ile Val 
                165                 170                 175     


Leu Thr Asp Phe Gly Leu Ser Lys Glu Phe Leu Thr Glu Glu Lys Glu 
            180                 185                 190         


Arg Thr Phe Ser Phe Cys Gly Thr Ile Glu Tyr Met Ala Pro Glu Ile 
        195                 200                 205             


Ile Arg Ser Lys Thr Gly His Gly Lys Ala Val Asp Trp Trp Ser Leu 
    210                 215                 220                 


Gly Ile Leu Leu Phe Glu Leu Leu Thr Gly Ala Ser Pro Phe Thr Leu 
225                 230                 235                 240 


Glu Gly Glu Arg Asn Thr Gln Ala Glu Val Ser Arg Arg Ile Leu Lys 
                245                 250                 255     


Cys Ser Pro Pro Phe Pro Pro Arg Ile Gly Pro Val Ala Gln Asp Leu 
            260                 265                 270         


Leu Gln Arg Leu Leu Cys Lys Asp Pro Lys Lys Arg Leu Gly Ala Gly 
        275                 280                 285             


Pro Gln Gly Ala Gln Glu Val Arg Asn His Pro Phe Phe Gln Gly Leu 
    290                 295                 300                 


Asp Trp Val Ala Leu Ala Ala Arg Lys Ile Pro Ala Pro Phe Arg Pro 
305                 310                 315                 320 


Gln Ile Arg Ser Glu Leu Asp Val Gly Asn Phe Ala Glu Glu Phe Thr 
                325                 330                 335     


Arg Leu Glu Pro Val Tyr Ser Pro Pro Gly Ser Pro Pro Pro Gly Asp 
            340                 345                 350         


Pro Arg Ile Phe Gln Gly Tyr Ser Phe Val Ala Pro Ser Ile Leu Phe 
        355                 360                 365             


Asp His Asn Asn Ala Val Met Thr Asp Gly Leu Glu Ala Pro Gly Ala 
    370                 375                 380                 


Gly Asp Arg Pro Gly Arg Ala Ala Val Ala Arg Ser Ala Met Met Gln 
385                 390                 395                 400 


Asp Ser Pro Phe Phe Gln Gln Tyr Glu Leu Asp Leu Arg Glu Pro Ala 
                405                 410                 415     


Leu Gly Gln Gly Ser Phe Ser Val Cys Arg Arg Cys Arg Gln Arg Gln 
            420                 425                 430         


Ser Gly Gln Glu Phe Ala Val Lys Ile Leu Ser Arg Arg Leu Glu Ala 
        435                 440                 445             


Asn Thr Gln Arg Glu Val Ala Ala Leu Arg Leu Cys Gln Ser His Pro 
    450                 455                 460                 


Asn Val Val Asn Leu His Glu Val His His Asp Gln Leu His Thr Tyr 
465                 470                 475                 480 


Leu Val Leu Glu Leu Leu Arg Gly Gly Glu Leu Leu Glu His Ile Arg 
                485                 490                 495     


Lys Lys Arg His Phe Ser Glu Ser Glu Ala Ser Gln Ile Leu Arg Ser 
            500                 505                 510         


Leu Val Ser Ala Val Ser Phe Met His Glu Glu Ala Gly Val Val His 
        515                 520                 525             


Arg Asp Leu Lys Pro Glu Asn Ile Leu Tyr Ala Asp Asp Thr Pro Gly 
    530                 535                 540                 


Ala Pro Val Lys Ile Ile Asp Phe Gly Phe Ala Arg Leu Arg Pro Gln 
545                 550                 555                 560 


Ser Pro Gly Val Pro Met Gln Thr Pro Cys Phe Thr Leu Gln Tyr Ala 
                565                 570                 575     


Ala Pro Glu Leu Leu Ala Gln Gln Gly Tyr Asp Glu Ser Cys Asp Leu 
            580                 585                 590         


Trp Ser Leu Gly Val Ile Leu Tyr Met Met Leu Ser Gly Gln Val Pro 
        595                 600                 605             


Phe Gln Gly Ala Ser Gly Gln Gly Gly Gln Ser Gln Ala Ala Glu Ile 
    610                 615                 620                 


Met Cys Lys Ile Arg Glu Gly Arg Phe Ser Leu Asp Gly Glu Ala Trp 
625                 630                 635                 640 


Gln Gly Val Ser Glu Glu Ala Lys Glu Leu Val Arg Gly Leu Leu Thr 
                645                 650                 655     


Val Asp Pro Ala Lys Arg Leu Lys Leu Glu Gly Leu Arg Gly Ser Ser 
            660                 665                 670         


Trp Leu Gln Asp Gly Ser Ala Arg Ser Ser Pro Pro Leu Arg Thr Pro 
        675                 680                 685             


Asp Val Leu Glu Ser Ser Gly Pro Ala Val Arg Ser Gly Leu Asn Ala 
    690                 695                 700                 


Thr Phe Met Ala Phe Asn Arg Gly Lys Arg Glu Gly Phe Phe Leu Lys 
705                 710                 715                 720 


Ser Val Glu Asn Ala Pro Leu Ala Lys Arg Arg Lys Gln Lys Leu Arg 
                725                 730                 735     


Ser Ala Thr Ala Ser Arg Arg Gly Ser Pro Ala Pro Ala Asn Pro Gly 
            740                 745                 750         


Arg Ala Pro Val Ala Ser Lys Gly Ala Pro Arg Arg Ala Asn Gly Pro 
        755                 760                 765             


Leu Pro Pro Ser 
    770         


<210>  38
<211>  281
<212>  PRT
<213>  Escherichia coli

<400>  38

Met Ala Thr Asn Phe Leu Ala His Glu Lys Ile Trp Phe Asp Lys Phe 
1               5                   10                  15      


Lys Tyr Asp Asp Ala Glu Arg Arg Phe Tyr Glu Gln Met Asn Gly Pro 
            20                  25                  30          


Val Ala Gly Ala Ser Arg Gln Glu Asn Gly Ala Ser Val Ile Leu Arg 
        35                  40                  45              


Asp Ile Ala Arg Ala Arg Glu Asn Ile Gln Lys Ser Leu Ala Gly Ser 
    50                  55                  60                  


Ser Gly Pro Gly Ala Ser Ser Gly Thr Ser Gly Asp His Gly Glu Leu 
65                  70                  75                  80  


Val Val Arg Ile Ala Ser Leu Glu Val Glu Asn Gln Ser Leu Arg Gly 
                85                  90                  95      


Val Val Gln Glu Leu Gln Gln Ala Ile Ser Lys Leu Glu Ala Arg Leu 
            100                 105                 110         


Asn Val Leu Glu Lys Ser Ser Pro Gly His Arg Ala Thr Ala Pro Gln 
        115                 120                 125             


Thr Gln His Val Ser Pro Met Arg Gln Val Glu Pro Pro Ala Lys Lys 
    130                 135                 140                 


Pro Ala Thr Pro Ala Glu Asp Asp Glu Asp Asp Asp Ile Asp Leu Phe 
145                 150                 155                 160 


Gly Ser Asp Asn Glu Glu Glu Asp Lys Glu Ala Ala Gln Leu Arg Glu 
                165                 170                 175     


Glu Arg Leu Arg Gln Tyr Ala Glu Lys Lys Ala Lys Lys Pro Ala Leu 
            180                 185                 190         


Val Ala Lys Ser Ser Ile Leu Leu Asp Val Lys Pro Trp Asp Asp Glu 
        195                 200                 205             


Thr Asp Met Ala Gln Leu Glu Ala Cys Val Arg Ser Ile Gln Leu Asp 
    210                 215                 220                 


Gly Leu Val Trp Gly Ala Ser Lys Leu Val Pro Val Gly Tyr Gly Ile 
225                 230                 235                 240 


Arg Lys Leu Gln Ile Gln Cys Val Val Glu Asp Asp Lys Val Gly Thr 
                245                 250                 255     


Asp Leu Leu Glu Glu Glu Ile Thr Lys Phe Glu Glu His Val Gln Ser 
            260                 265                 270         


Val Asp Ile Ala Ala Phe Asn Lys Ile 
        275                 280     


<210>  39
<211>  480
<212>  PRT
<213>  Escherichia coli

<400>  39

Met Leu Asn Phe Gly Ala Ser Leu Gln Gln Thr Ala Glu Glu Arg Met 
1               5                   10                  15      


Glu Met Ile Ser Glu Arg Pro Lys Glu Ser Met Tyr Ser Trp Asn Lys 
            20                  25                  30          


Thr Ala Glu Lys Ser Asp Phe Glu Ala Val Glu Ala Leu Met Ser Met 
        35                  40                  45              


Ser Cys Ser Trp Lys Ser Asp Phe Lys Lys Tyr Val Glu Asn Arg Pro 
    50                  55                  60                  


Val Thr Pro Val Ser Asp Leu Ser Glu Glu Glu Asn Leu Leu Pro Gly 
65                  70                  75                  80  


Thr Pro Asp Phe His Thr Ile Pro Ala Phe Cys Leu Thr Pro Pro Tyr 
                85                  90                  95      


Ser Pro Ser Asp Phe Glu Pro Ser Gln Val Ser Asn Leu Met Ala Pro 
            100                 105                 110         


Ala Pro Ser Thr Val His Phe Lys Ser Leu Ser Asp Thr Ala Lys Pro 
        115                 120                 125             


His Ile Ala Ala Pro Phe Lys Glu Glu Glu Lys Ser Pro Val Ser Ala 
    130                 135                 140                 


Pro Lys Leu Pro Lys Ala Gln Ala Thr Ser Val Ile Arg His Thr Ala 
145                 150                 155                 160 


Asp Ala Gln Leu Cys Asn His Gln Thr Cys Pro Met Lys Ala Ala Ser 
                165                 170                 175     


Ile Leu Asn Tyr Gln Asn Asn Ser Phe Arg Arg Arg Thr His Leu Asn 
            180                 185                 190         


Val Glu Ala Ala Arg Lys Asn Ile Pro Cys Ala Ala Val Ser Pro Asn 
        195                 200                 205             


Arg Ser Lys Cys Glu Arg Asn Thr Val Ala Asp Val Asp Glu Lys Ala 
    210                 215                 220                 


Ser Ala Ala Leu Tyr Asp Phe Ser Val Pro Ser Ser Glu Thr Val Ile 
225                 230                 235                 240 


Cys Arg Ser Gln Pro Ala Pro Val Ser Pro Gln Gln Lys Ser Val Leu 
                245                 250                 255     


Val Ser Pro Pro Ala Val Ser Ala Gly Gly Val Pro Pro Met Pro Val 
            260                 265                 270         


Ile Cys Gln Met Val Pro Leu Pro Ala Asn Asn Pro Val Val Thr Thr 
        275                 280                 285             


Val Val Pro Ser Thr Pro Pro Ser Gln Pro Pro Ala Val Cys Pro Pro 
    290                 295                 300                 


Val Val Phe Met Gly Thr Gln Val Pro Lys Gly Ala Val Met Phe Val 
305                 310                 315                 320 


Val Pro Gln Pro Val Val Gln Ser Ser Lys Pro Pro Val Val Ser Pro 
                325                 330                 335     


Asn Gly Thr Arg Leu Ser Pro Ile Ala Pro Ala Pro Gly Phe Ser Pro 
            340                 345                 350         


Ser Ala Ala Lys Val Thr Pro Gln Ile Asp Ser Ser Arg Ile Arg Ser 
        355                 360                 365             


His Ile Cys Ser His Pro Gly Cys Gly Lys Thr Tyr Phe Lys Ser Ser 
    370                 375                 380                 


His Leu Lys Ala His Thr Arg Thr His Thr Gly Glu Lys Pro Phe Ser 
385                 390                 395                 400 


Cys Ser Trp Lys Gly Cys Glu Arg Arg Phe Ala Arg Ser Asp Glu Leu 
                405                 410                 415     


Ser Arg His Arg Arg Thr His Thr Gly Glu Lys Lys Phe Ala Cys Pro 
            420                 425                 430         


Met Cys Asp Arg Arg Phe Met Arg Ser Asp His Leu Thr Lys His Ala 
        435                 440                 445             


Arg Arg His Leu Ser Ala Lys Lys Leu Pro Asn Trp Gln Met Glu Val 
    450                 455                 460                 


Ser Lys Leu Asn Asp Ile Ala Leu Pro Pro Thr Pro Ala Pro Thr Gln 
465                 470                 475                 480 


<210>  40
<211>  976
<212>  PRT
<213>  Escherichia coli

<400>  40

Met Glu Leu Gln Ala Ala Arg Ala Cys Phe Ala Leu Leu Trp Gly Cys 
1               5                   10                  15      


Ala Leu Ala Ala Ala Ala Ala Ala Gln Gly Lys Glu Val Val Leu Leu 
            20                  25                  30          


Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly Trp Leu Thr His Pro Tyr 
        35                  40                  45              


Gly Lys Gly Trp Asp Leu Met Gln Asn Ile Met Asn Asp Met Pro Ile 
    50                  55                  60                  


Tyr Met Tyr Ser Val Cys Asn Val Met Ser Gly Asp Gln Asp Asn Trp 
65                  70                  75                  80  


Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu Ala Glu Arg Ile Phe Ile 
                85                  90                  95      


Glu Leu Lys Phe Thr Val Arg Asp Cys Asn Ser Phe Pro Gly Gly Ala 
            100                 105                 110         


Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Ala Glu Ser Asp Leu 
        115                 120                 125             


Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu Phe Thr Lys Ile Asp Thr 
    130                 135                 140                 


Ile Ala Pro Asp Glu Ile Thr Val Ser Ser Asp Phe Glu Ala Arg His 
145                 150                 155                 160 


Val Lys Leu Asn Val Glu Glu Arg Ser Val Gly Pro Leu Thr Arg Lys 
                165                 170                 175     


Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Val Ala Leu Leu 
            180                 185                 190         


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Glu Leu Leu Gln Gly Leu 
        195                 200                 205             


Ala His Phe Pro Glu Thr Ile Ala Gly Ser Asp Ala Pro Ser Leu Ala 
    210                 215                 220                 


Thr Val Ala Gly Thr Cys Val Asp His Ala Val Val Pro Pro Gly Gly 
225                 230                 235                 240 


Glu Glu Pro Arg Met His Cys Ala Val Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr Glu Lys Val Glu Asp Ala 
            260                 265                 270         


Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys Phe Glu Ala Ser Glu Ser 
        275                 280                 285             


Pro Cys Leu Glu Cys Pro Glu His Thr Leu Pro Ser Pro Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe Arg Ala Pro Gln Asp Pro 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro His Tyr Leu Thr 
                325                 330                 335     


Ala Val Gly Met Gly Ala Lys Val Glu Leu Arg Trp Thr Pro Pro Gln 
            340                 345                 350         


Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr Ser Val Thr Cys Glu Gln 
        355                 360                 365             


Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro Cys Glu Ala Ser Val Arg 
    370                 375                 380                 


Tyr Ser Glu Pro Pro His Gly Leu Thr Arg Thr Ser Val Thr Val Ser 
385                 390                 395                 400 


Asp Leu Glu Pro His Met Asn Tyr Thr Phe Thr Val Glu Ala Arg Asn 
                405                 410                 415     


Gly Val Ser Gly Leu Val Thr Ser Arg Ser Phe Arg Thr Ala Ser Val 
            420                 425                 430         


Ser Ile Asn Gln Thr Glu Pro Pro Lys Val Arg Leu Glu Gly Arg Ser 
        435                 440                 445             


Thr Thr Ser Leu Ser Val Ser Trp Ser Ile Pro Pro Pro Gln Gln Ser 
    450                 455                 460                 


Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg Lys Lys Gly Asp Ser Asn 
465                 470                 475                 480 


Ser Tyr Asn Val Arg Arg Thr Glu Gly Phe Ser Val Thr Leu Asp Asp 
                485                 490                 495     


Leu Ala Pro Asp Thr Thr Tyr Leu Val Gln Val Gln Ala Leu Thr Gln 
            500                 505                 510         


Glu Gly Gln Gly Ala Gly Ser Lys Val His Glu Phe Gln Thr Leu Ser 
        515                 520                 525             


Pro Glu Gly Ser Gly Asn Leu Ala Val Ile Gly Gly Val Ala Val Gly 
    530                 535                 540                 


Val Val Leu Leu Leu Val Leu Ala Gly Val Gly Phe Phe Ile His Arg 
545                 550                 555                 560 


Arg Arg Lys Asn Gln Arg Ala Arg Gln Ser Pro Glu Asp Val Tyr Phe 
                565                 570                 575     


Ser Lys Ser Glu Gln Leu Lys Pro Leu Lys Thr Tyr Val Asp Pro His 
            580                 585                 590         


Thr Tyr Glu Asp Pro Asn Gln Ala Val Leu Lys Phe Thr Thr Glu Ile 
        595                 600                 605             


His Pro Ser Cys Val Thr Arg Gln Lys Val Ile Gly Ala Gly Glu Phe 
    610                 615                 620                 


Gly Glu Val Tyr Lys Gly Met Leu Lys Thr Ser Ser Gly Lys Lys Glu 
625                 630                 635                 640 


Val Pro Val Ala Ile Lys Thr Leu Lys Ala Gly Tyr Thr Glu Lys Gln 
                645                 650                 655     


Arg Val Asp Phe Leu Gly Glu Ala Gly Ile Met Gly Gln Phe Ser His 
            660                 665                 670         


His Asn Ile Ile Arg Leu Glu Gly Val Ile Ser Lys Tyr Lys Pro Met 
        675                 680                 685             


Met Ile Ile Thr Glu Tyr Met Glu Asn Gly Ala Leu Asp Lys Phe Leu 
    690                 695                 700                 


Arg Glu Lys Asp Gly Glu Phe Ser Val Leu Gln Leu Val Gly Met Leu 
705                 710                 715                 720 


Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Asn Met Asn Tyr Val 
                725                 730                 735     


His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val 
            740                 745                 750         


Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro 
        755                 760                 765             


Glu Ala Thr Tyr Thr Thr Ser Gly Gly Lys Ile Pro Ile Arg Trp Thr 
    770                 775                 780                 


Ala Pro Glu Ala Ile Ser Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val 
785                 790                 795                 800 


Trp Ser Phe Gly Ile Val Met Trp Glu Val Met Thr Tyr Gly Glu Arg 
                805                 810                 815     


Pro Tyr Trp Glu Leu Ser Asn His Glu Val Met Lys Ala Ile Asn Asp 
            820                 825                 830         


Gly Phe Arg Leu Pro Thr Pro Met Asp Cys Pro Ser Ala Ile Tyr Gln 
        835                 840                 845             


Leu Met Met Gln Cys Trp Gln Gln Glu Arg Ala Arg Arg Pro Lys Phe 
    850                 855                 860                 


Ala Asp Ile Val Ser Ile Leu Asp Lys Leu Ile Arg Ala Pro Asp Ser 
865                 870                 875                 880 


Leu Lys Thr Leu Ala Asp Phe Asp Pro Arg Val Ser Ile Arg Leu Pro 
                885                 890                 895     


Ser Thr Ser Gly Ser Glu Gly Val Pro Phe Arg Thr Val Ser Glu Trp 
            900                 905                 910         


Leu Glu Ser Ile Lys Met Gln Gln Tyr Thr Glu His Phe Met Ala Ala 
        915                 920                 925             


Gly Tyr Thr Ala Ile Glu Lys Val Val Gln Met Thr Asn Asp Asp Ile 
    930                 935                 940                 


Lys Arg Ile Gly Val Arg Leu Pro Gly His Gln Lys Arg Ile Ala Tyr 
945                 950                 955                 960 


Ser Leu Leu Gly Leu Lys Asp Gln Val Asn Thr Val Gly Ile Pro Ile 
                965                 970                 975     


<210>  41
<211>  381
<212>  PRT
<213>  Escherichia coli

<400>  41

Met Glu Ser Gly Ser Thr Ala Ala Ser Glu Glu Ala Arg Ser Leu Arg 
1               5                   10                  15      


Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala Leu Leu Lys 
            20                  25                  30          


Asp Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg Pro Met Ala 
        35                  40                  45              


Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu Ala Lys Gln 
    50                  55                  60                  


Ile Gln Asn Leu Gln Lys Ala Gly Thr Arg Thr Asp Ser Arg Glu Asp 
65                  70                  75                  80  


Glu Ile Ser Pro Pro Pro Pro Asn Pro Val Val Lys Gly Arg Arg Arg 
                85                  90                  95      


Arg Gly Ala Ile Ser Ala Glu Val Tyr Thr Glu Glu Asp Ala Ala Ser 
            100                 105                 110         


Tyr Val Arg Lys Val Ile Pro Lys Asp Tyr Lys Thr Met Ala Ala Leu 
        115                 120                 125             


Ala Lys Ala Ile Glu Lys Asn Val Leu Phe Ser His Leu Asp Asp Asn 
    130                 135                 140                 


Glu Arg Ser Asp Ile Phe Asp Ala Met Phe Ser Val Ser Phe Ile Ala 
145                 150                 155                 160 


Gly Glu Thr Val Ile Gln Gln Gly Asp Glu Gly Asp Asn Phe Tyr Val 
                165                 170                 175     


Ile Asp Gln Gly Glu Thr Asp Val Tyr Val Asn Asn Glu Trp Ala Thr 
            180                 185                 190         


Ser Val Gly Glu Gly Gly Ser Phe Gly Glu Leu Ala Leu Ile Tyr Gly 
        195                 200                 205             


Thr Pro Arg Ala Ala Thr Val Lys Ala Lys Thr Asn Val Lys Leu Trp 
    210                 215                 220                 


Gly Ile Asp Arg Asp Ser Tyr Arg Arg Ile Leu Met Gly Ser Thr Leu 
225                 230                 235                 240 


Arg Lys Arg Lys Met Tyr Glu Glu Phe Leu Ser Lys Val Ser Ile Leu 
                245                 250                 255     


Glu Ser Leu Asp Lys Trp Glu Arg Leu Thr Val Ala Asp Ala Leu Glu 
            260                 265                 270         


Pro Val Gln Phe Glu Asp Gly Gln Lys Ile Val Val Gln Gly Glu Pro 
        275                 280                 285             


Gly Asp Glu Phe Phe Ile Ile Leu Glu Gly Ser Ala Ala Val Leu Gln 
    290                 295                 300                 


Arg Arg Ser Glu Asn Glu Glu Phe Val Glu Val Gly Arg Leu Gly Pro 
305                 310                 315                 320 


Ser Asp Tyr Phe Gly Glu Ile Ala Leu Leu Met Asn Arg Pro Arg Ala 
                325                 330                 335     


Ala Thr Val Val Ala Arg Gly Pro Leu Lys Cys Val Lys Leu Asp Arg 
            340                 345                 350         


Pro Arg Phe Glu Arg Val Leu Gly Pro Cys Ser Asp Ile Leu Lys Arg 
        355                 360                 365             


Asn Ile Gln Gln Tyr Asn Ser Phe Val Ser Leu Ser Val 
    370                 375                 380     


<210>  42
<211>  285
<212>  PRT
<213>  Escherichia coli

<400>  42

Met Asn Arg Leu Pro Asp Asp Tyr Asp Pro Tyr Ala Val Glu Glu Pro 
1               5                   10                  15      


Ser Asp Glu Glu Pro Ala Leu Ser Ser Ser Glu Asp Glu Val Asp Val 
            20                  25                  30          


Leu Leu His Gly Thr Pro Asp Gln Lys Arg Lys Leu Ile Arg Glu Cys 
        35                  40                  45              


Leu Thr Gly Glu Ser Glu Ser Ser Ser Glu Asp Glu Phe Glu Lys Glu 
    50                  55                  60                  


Met Glu Ala Glu Leu Asn Ser Thr Met Lys Thr Met Glu Asp Lys Leu 
65                  70                  75                  80  


Ser Ser Leu Gly Thr Gly Ser Ser Ser Gly Asn Gly Lys Val Ala Thr 
                85                  90                  95      


Ala Pro Thr Arg Tyr Tyr Asp Asp Ile Tyr Phe Asp Ser Asp Ser Glu 
            100                 105                 110         


Asp Glu Asp Arg Ala Val Gln Val Thr Lys Lys Lys Lys Lys Lys Gln 
        115                 120                 125             


His Lys Ile Pro Thr Asn Asp Glu Leu Leu Tyr Asp Pro Glu Lys Asp 
    130                 135                 140                 


Asn Arg Asp Gln Ala Trp Val Asp Ala Gln Arg Arg Gly Tyr His Gly 
145                 150                 155                 160 


Leu Gly Pro Gln Arg Ser Arg Gln Gln Gln Pro Val Pro Asn Ser Asp 
                165                 170                 175     


Ala Val Leu Asn Cys Pro Ala Cys Met Thr Thr Leu Cys Leu Asp Cys 
            180                 185                 190         


Gln Arg His Glu Ser Tyr Lys Thr Gln Tyr Arg Ala Met Phe Val Met 
        195                 200                 205             


Asn Cys Ser Ile Asn Lys Glu Glu Val Leu Arg Tyr Lys Ala Ser Glu 
    210                 215                 220                 


Asn Arg Lys Lys Arg Arg Val His Lys Lys Met Arg Ser Asn Arg Glu 
225                 230                 235                 240 


Asp Ala Ala Glu Lys Ala Glu Thr Asp Val Glu Glu Ile Tyr His Pro 
                245                 250                 255     


Val Met Cys Thr Glu Cys Ser Thr Glu Val Ala Val Tyr Asp Lys Asp 
            260                 265                 270         


Glu Val Phe His Phe Phe Asn Val Leu Ala Ser His Ser 
        275                 280                 285 


