<110>    OATC Inc
         Daegu Gyeongbuk Institute of Science and Technology

<120>    Composition for preventing or treating of neuroinflammatory
         disease comprising didanosine

<130>    OPP20215230KR

<150>    KR 10-2020-0156060
<151>    2020-11-19

<160>    4

<170>    KoPatentIn 3.0

<210>    1
<211>    1347
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Psen2 N141I


<400>    1
atgctcgcat tcatggcctc tgacagcgag gaagaggtgt gtgatgagcg gacgtccttg         60

atgtcagccg agagccccac atctcgctcc tgccaggaag gcaggccagg cccggaggat        120

ggagagagca ctgcccagtg gaggactcag gagagcgaag aagactgtga agaggacccg        180

gaccgctacg catgcagtgg ggctcctggg cgaccgtcgg gcctggagga agagctgacc        240

ctcaagtatg gggcgaagca tgtgatcatg ctattcgtgc ctgtcacgct gtgtatgatc        300

gtggtggtgg ccactatcaa gtctgtgcgt ttctacactg agaagaacgg gcagctcatc        360

tacacgccct tcacggagga cacgccctcg gtgggccagc ggctcctcaa ctccgtgctt        420

atcaccctca tcatgatcag cgtcatcgta gtcatgacca tcttcctcgt ggtactctac        480

aagtatcgat gctacaagtt catccatggc tggctgatca tgtcctccct gatgctcctc        540

ttcttgttca cctacatcta cctcggggaa gtgctcaaga cctacaatgt ggccatggac        600

tatcccacac tcttcctggc tgtctggaac ttcggggcag tgggcatggt gtgcatccac        660

tggaaggggc ctctggtgct gcagcaggct taccttattg tgatcagcgc actcatggcc        720

ctggtgttca tcaagtacct gccggagtgg tctgcctggg tcatcttggg tgccatctct        780

gtgtacgatc tcgtggccgt gctgtgcccc aaagggccac tgaggatgct ggtggaaact        840

gcccaggaga gaaatgagcc catatttcct gccctgatat actcatctgc catggtgtgg        900

acggtgggca tggcaaagct ggacccctcc tctcaaggag cgctgcagct cccctatgac        960

ccagagatgg aagaagactc ctacgacagt tttggagaac cctcataccc tgaagccttc       1020

gaagcccccc tgcctggcta cccaggggag gagctggagg aggaggagga aaggggcgtg       1080

aagctcggcc tgggagactt catcttctac agcgtcctgg tgggcaaggc tgcagccact       1140

ggcaacggag actggaacac tacgctggcc tgttttatcg ccatcctcat tggcttgtgt       1200

ctcaccctcc tgctgcttgc tgtgttcaag aaggctctgc ccgccctccc catctccatc       1260

acctttggac tcatcttcta cttctccaca gacaacctgg tgcgcccttt catggacact       1320

ctggcctccc accagctcta catctga                                           1347


<210>    2
<211>    1347
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Psen2 wild type


<400>    2
atgctcgcat tcatggcctc tgacagcgag gaagaggtgt gtgatgagcg gacgtccttg         60

atgtcagccg agagccccac atctcgctcc tgccaggaag gcaggccagg cccggaggat        120

ggagagagca ctgcccagtg gaggactcag gagagcgaag aagactgtga agaggacccg        180

gaccgctacg catgcagtgg ggctcctggg cgaccgtcgg gcctggagga agagctgacc        240

ctcaagtatg gggcgaagca tgtgatcatg ctattcgtgc ctgtcacgct gtgtatgatc        300

gtggtggtgg ccactatcaa gtctgtgcgt ttctacactg agaagaacgg gcagctcatc        360

tacacgccct tcacggagga cacgccctcg gtgggccagc ggctcctcaa ctccgtgctt        420

atcaccctca tcatgatcag cgtcatcgta gtcatgacca tcttcctcgt ggtactctac        480

aagtatcgat gctacaagtt catccatggc tggctgatca tgtcctccct gatgctcctc        540

ttcttgttca cctacatcta cctcggggaa gtgctcaaga cctacaatgt ggccatggac        600

tatcccacac tcttcctggc tgtctggaac ttcggggcag tgggcatggt gtgcatccac        660

tggaaggggc ctctggtgct gcagcaggct taccttattg tgatcagcgc actcatggcc        720

ctggtgttca tcaagtacct gccggagtgg tctgcctggg tcatcttggg tgccatctct        780

gtgtacgatc tcgtggccgt gctgtgcccc aaagggccac tgaggatgct ggtggaaact        840

gcccaggaga gaaatgagcc catatttcct gccctgatat actcatctgc catggtgtgg        900

acggtgggca tggcaaagct ggacccctcc tctcaaggag cgctgcagct cccctatgac        960

ccagagatgg aagaagactc ctacgacagt tttggagaac cctcataccc tgaagccttc       1020

gaagcccccc tgcctggcta cccaggggag gagctggagg aggaggagga aaggggcgtg       1080

aagctcggcc tgggagactt catcttctac agcgtcctgg tgggcaaggc tgcagccact       1140

ggcaacggag actggaacac tacgctggcc tgttttatcg ccatcctcat tggcttgtgt       1200

ctcaccctcc tgctgcttgc tgtgttcaag aaggctctgc ccgccctccc catctccatc       1260

acctttggac tcatcttcta cttctccaca gacaacctgg tgcgcccttt catggacact       1320

ctggcctccc accagctcta catctga                                           1347


<210>    3
<211>    23
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Primer(F) for IL-6


<400>    3
ctggatataa tcaggaaatt tgc                                                 23


<210>    4
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Primer(R) for IL-6


<400>    4
aaatctttta cctcttggtt ga                                                  22

