                               SEQUENCE LISTING

<110> LEMBA THERAPEUTICS
 
<120> UMLILO ANTISENSE TRANSCRIPTION INHIBITORS

<130> 269607-498263

<140>
<141>

<150> 63/235,890
<151> 2021-08-23

<150> 63/115,448
<151> 2020-11-18

<160> 297   

<170> PatentIn version 3.5

<210> 1
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 1
catttccaac ttgtagggtt                                                   20


<210> 2
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 2
gtgtttgaga ggagccattt                                                   20


<210> 3
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 3
agtgtttgag aggagccatt                                                   20


<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 4
gtagcagata catttgggct                                                   20


<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 5
agtagcagat acatttgggc                                                   20


<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 6
ttttgcatta tggaaggcac                                                   20


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 7
gttttgcatt atggaaggca                                                   20


<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 8
caattttggt agcagtagac                                                   20


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 9
ggttacaatt ttggtagcag                                                   20


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 10
gatgggggtt acaattttgg                                                   20


<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 11
tgatgggggt tacaattttg                                                   20


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 12
tactagatga tgggggttac                                                   20


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 13
ttactagatg atgggggtta                                                   20


<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 14
ctggaatgaa gcagaataca                                                   20


<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 15
tctggaatga agcagaatac                                                   20


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 16
aggcctctgg aatgaagcag                                                   20


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 17
agtattctat gtgagcagct                                                   20


<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 18
aagtattcta tgtgagcagc                                                   20


<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 19
actggtgaaa atggaagtca                                                   20


<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 20
aactggtgaa aatggaagtc                                                   20


<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 21
ttacagacta tacagtttag                                                   20


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 22
tttacagact atacagttta                                                   20


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 23
cagactatac agtttagtag                                                   20


<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 24
acagactata cagtttagta                                                   20


<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 25
tacagactat acagtttagt                                                   20


<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 26
ctttacagac tatacagttt                                                   20


<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 27
cctttacaga ctatacagtt                                                   20


<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 28
gactgagata aatacagttc                                                   20


<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 29
tgactgagat aaatacagtt                                                   20


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 30
atacagttta gtagactcaa                                                   20


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 31
tgcctttaca gactatacag                                                   20


<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 32
gcctttacag actatacagt                                                   20


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 33
ctgcctttac agactataca                                                   20


<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 34
tatacagttt agtagactca                                                   20


<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 35
cctgccttta cagactatac                                                   20


<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 36
acttcttgag cagtaattca                                                   20


<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 37
cttcttgagc agtaattcag                                                   20


<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 38
ttcttgagca gtaattcagc                                                   20


<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 39
tacttcttga gcagtaattc                                                   20


<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 40
tcttgagcag taattcagca                                                   20


<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 41
tcctgccttt acagactata                                                   20


<210> 42
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 42
aaggcatgtg gatctatact                                                   20


<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 43
cttgagcagt aattcagcat                                                   20


<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 44
aggcatgtgg atctatactt                                                   20


<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 45
ttgagcagta attcagcatc                                                   20


<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 46
ctgaagttga aggcatgtgg                                                   20


<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 47
tctgaagttg aaggcatgtg                                                   20


<210> 48
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 48
ttctgaagtt gaaggcatgt                                                   20


<210> 49
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 49
tttaagattc tgaagttgaa                                                   20


<210> 50
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 50
atgtggatct atacttcttg                                                   20


<210> 51
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 51
tgtggatcta tacttcttga                                                   20


<210> 52
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 52
tgaaggcatg tggatctata                                                   20


<210> 53
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 53
ttgaaggcat gtggatctat                                                   20


<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 54
gtggatctat acttcttgag                                                   20


<210> 55
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 55
tctatacttc ttgagcagta                                                   20


<210> 56
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 56
atctatactt cttgagcagt                                                   20


<210> 57
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 57
tggatctata cttcttgagc                                                   20


<210> 58
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 58
acagttcctg cctttacaga                                                   20


<210> 59
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 59
ctatacttct tgagcagtaa                                                   20


<210> 60
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 60
ggatctatac ttcttgagca                                                   20


<210> 61
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 61
tatacttctt gagcagtaat                                                   20


<210> 62
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 62
gatctatact tcttgagcag                                                   20


<210> 63
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 63
tgagcagtaa ttcagcatct                                                   20


<210> 64
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 64
ctggagtgtt gctgcg                                                       16


<210> 65
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 65
tgttcaccgt gtacca                                                       16


<210> 66
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 66
ggggttacaa ttttgg                                                       16


<210> 67
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 67
tatgcagact aaaaaa                                                       16


<210> 68
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 68
ttaagattct gaagtt                                                       16


<210> 69
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 69
cagactaaaa aagatc                                                       16


<210> 70
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 70
ccacacataa agcgcc                                                       16


<210> 71
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 71
ctcaacattc gcctct                                                       16


<210> 72
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 72
tttacagact atacag                                                       16


<210> 73
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 73
actatacagt ttagta                                                       16


<210> 74
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 74
ctatacagtt tagtag                                                       16


<210> 75
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 75
agttcctgcc tttaca                                                       16


<210> 76
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 76
taaagcgccc tggagt                                                       16


<210> 77
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 77
gctgcgagaa tttgta                                                       16


<210> 78
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 78
agatgaactg ttatga                                                       16


<210> 79
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 79
ttactagatg atgggg                                                       16


<210> 80
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 80
taatttaaga ttctga                                                       16


<210> 81
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 81
tactagatga tggggg                                                       16


<210> 82
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 82
atgcagacta aaaaag                                                       16


<210> 83
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 83
acattcgcct ctaatt                                                       16


<210> 84
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 84
tacagactat acagtt                                                       16


<210> 85
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 85
gactgagata aataca                                                       16


<210> 86
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 86
tatacagttt agtaga                                                       16


<210> 87
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 87
gttcctgcct ttacag                                                       16


<210> 88
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 88
gcaggcctct ggaatg                                                       16


<210> 89
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 89
ttgggctgct ctatct                                                       16


<210> 90
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 90
ctgatctaaa ctggtg                                                       16


<210> 91
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 91
ttaacacaga tgaact                                                       16


<210> 92
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 92
ctaatttaag attctg                                                       16


<210> 93
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 93
actctttact agatga                                                       16


<210> 94
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 94
tctttactag atgatg                                                       16


<210> 95
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 95
tagactcaac attcgc                                                       16


<210> 96
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 96
ctttacagac tataca                                                       16


<210> 97
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 97
actgagataa atacag                                                       16


<210> 98
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 98
ttacagacta tacagt                                                       16


<210> 99
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 99
taatctccac atgtat                                                       16


<210> 100
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 100
cacataaagc gccctg                                                       16


<210> 101
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 101
gcattatgga aggcac                                                       16


<210> 102
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 102
gagattaaga attggc                                                       16


<210> 103
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 103
gttaacacag atgaac                                                       16


<210> 104
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 104
cctctaattt aagatt                                                       16


<210> 105
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 105
ctatgtgagc agctct                                                       16


<210> 106
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 106
aagattctga agttga                                                       16


<210> 107
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 107
aggcaccaca gtagca                                                       16


<210> 108
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 108
ttgcattatg gaaggc                                                       16


<210> 109
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 109
tccactgatc taaact                                                       16


<210> 110
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 110
gagtgttgct gcgaga                                                       16


<210> 111
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 111
tgttaacaca gatgaa                                                       16


<210> 112
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 112
agattctgaa gttgaa                                                       16


<210> 113
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 113
ataaagcgcc ctggag                                                       16


<210> 114
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 114
gggggttaca attttg                                                       16


<210> 115
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 115
agactataca gtttag                                                       16


<210> 116
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 116
tgactgagat aaatac                                                       16


<210> 117
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 117
ttcagcatct ctctgt                                                       16


<210> 118
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 118
cttaatctcc acatgt                                                       16


<210> 119
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 119
tatgtgagca gctctt                                                       16


<210> 120
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 120
ctagatgatg ggggtt                                                       16


<210> 121
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 121
ataaatacag ttcctg                                                       16


<210> 122
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 122
tttactagat gatggg                                                       16


<210> 123
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 123
gctgcgagaa tttgta                                                       16


<210> 124
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 124
tttaagattc tgaagt                                                       16


<210> 125
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 125
aacttgtagg gttaat                                                       16


<210> 126
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 126
ttgtagggtt aatatg                                                       16


<210> 127
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 127
cagactatac agttta                                                       16


<210> 128
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 128
tgagataaat acagtt                                                       16


<210> 129
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 129
gtcttaatct ccacat                                                       16


<210> 130
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 130
gcagtaattc agcatc                                                       16


<210> 131
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 131
tgaaggcatg tggatc                                                       16


<210> 132
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 132
agtgtttgag aggagc                                                       16


<210> 133
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 133
agtgttgctg cgagaa                                                       16


<210> 134
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 134
ctttactaga tgatgg                                                       16


<210> 135
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 135
ttgctgcgag aatttg                                                       16


<210> 136
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 136
atttaagatt ctgaag                                                       16


<210> 137
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 137
ccgtgtacca actctt                                                       16


<210> 138
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 138
cttgtagggt taatat                                                       16


<210> 139
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 139
cctttacaga ctatac                                                       16


<210> 140
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 140
tacttcttga gcagta                                                       16


<210> 141
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 141
cagttcctgc ctttac                                                       16


<210> 142
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 142
cagtaattca gcatct                                                       16


<210> 143
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 143
tgcattatgg aaggca                                                       16


<210> 144
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 144
agactcaaca ttcgcc                                                       16


<210> 145
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 145
gtgttgctgc gagaat                                                       16


<210> 146
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 146
gattctgaag ttgaag                                                       16


<210> 147
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 147
tgttgctgcg agaatt                                                       16


<210> 148
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 148
tggagtgttg ctgcga                                                       16


<210> 149
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 149
actcaacatt cgcctc                                                       16


<210> 150
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 150
tcgcctctaa tttaag                                                       16


<210> 151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 151
cttcttgagc agtaattcag                                                   20


<210> 152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (7)..(14)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (15)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 152
cttcttgagc agtaattcag                                                   20


<210> 153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(7)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (8)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 153
cttcttgagc agtaattcag                                                   20


<210> 154

<400> 154
000


<210> 155
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(18)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 155
ttcttgagca gtaattca                                                     18


<210> 156
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (5)..(12)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (13)..(16)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 156
tcttgagcag taattc                                                       16


<210> 157
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(11)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (12)..(16)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 157
tcttgagcag taattc                                                       16


<210> 158
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(17)
<223> cMe modified nucleoside

<400> 158
tcttgagcag taattca                                                      17


<210> 159
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(17)
<223> cMe modified nucleoside

<400> 159
tcttgagcag taattca                                                      17


<210> 160
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 160
tcttgagcag taattc                                                       16


<210> 161
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(12)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (13)..(16)
<223> cMe modified nucleoside

<400> 161
tcttgagcag taattc                                                       16


<210> 162
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'OMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 162
tcttgagcag taattc                                                       16


<210> 163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 163
tactagatga tgggggttac                                                   20


<210> 164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (7)..(14)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (15)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 164
tactagatga tgggggttac                                                   20


<210> 165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(7)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (8)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 165
tactagatga tgggggttac                                                   20


<210> 166
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (5)..(14)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (15)..(18)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 166
actagatgat gggggtta                                                     18


<210> 167
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(18)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 167
actagatgat gggggtta                                                     18


<210> 168
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (5)..(12)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (13)..(16)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 168
ctagatgatg ggggtt                                                       16


<210> 169
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(11)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (12)..(16)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 169
ctagatgatg ggggtt                                                       16


<210> 170
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(17)
<223> cMe modified nucleoside

<400> 170
ctagatgatg ggggtta                                                      17


<210> 171
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(17)
<223> cMe modified nucleoside

<400> 171
ctagatgatg ggggtta                                                      17


<210> 172
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 172
ctagatgatg ggggtt                                                       16


<210> 173
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(12)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (13)..(16)
<223> cMe modified nucleoside

<400> 173
ctagatgatg ggggtt                                                       16


<210> 174
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'OMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 174
ctagatgatg ggggtt                                                       16


<210> 175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 175
cctgccttta cagactatac                                                   20


<210> 176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (7)..(14)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (15)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 176
cctgccttta cagactatac                                                   20


<210> 177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(7)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (8)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 177
cctgccttta cagactatac                                                   20


<210> 178
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (5)..(14)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (15)..(18)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 178
ctgcctttac agactata                                                     18


<210> 179
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(18)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 179
ctgcctttac agactata                                                     18


<210> 180
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (5)..(12)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (13)..(16)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 180
tgcctttaca gactat                                                       16


<210> 181
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(11)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (12)..(16)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 181
tgcctttaca gactat                                                       16


<210> 182
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(17)
<223> cMe modified nucleoside

<400> 182
tgcctttaca gactata                                                      17


<210> 183
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(17)
<223> cMe modified nucleoside

<400> 183
tgcctttaca gactata                                                      17


<210> 184
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 184
tgcctttaca gactat                                                       16


<210> 185
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(12)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (13)..(16)
<223> cMe modified nucleoside

<400> 185
tgcctttaca gactat                                                       16


<210> 186
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'OMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 186
tgcctttaca gactat                                                       16


<210> 187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 187
ttacagacta tacagtttag                                                   20


<210> 188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (7)..(14)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (15)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 188
ttacagacta tacagtttag                                                   20


<210> 189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(7)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (8)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 189
ttacagacta tacagtttag                                                   20


<210> 190
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (5)..(14)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (15)..(18)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 190
tacagactat acagttta                                                     18


<210> 191
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(18)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 191
tacagactat acagttta                                                     18


<210> 192
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (5)..(12)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (13)..(16)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 192
acagactata cagttt                                                       16


<210> 193
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(11)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (12)..(16)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 193
acagactata cagttt                                                       16


<210> 194
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(17)
<223> cMe modified nucleoside

<400> 194
acagactata cagttta                                                      17


<210> 195
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(17)
<223> cMe modified nucleoside

<400> 195
acagactata cagttta                                                      17


<210> 196
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 196
cagactatac agttta                                                       16


<210> 197
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(12)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (13)..(16)
<223> cMe modified nucleoside

<400> 197
cagactatac agttta                                                       16


<210> 198
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'OMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 198
cagactatac agttta                                                       16


<210> 199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 199
cacacataaa gcgccctgga                                                   20


<210> 200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (7)..(14)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (15)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 200
cacacataaa gcgccctgga                                                   20


<210> 201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(7)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (8)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 201
cacacataaa gcgccctgga                                                   20


<210> 202
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (5)..(14)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (15)..(18)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 202
acacataaag cgccctgg                                                     18


<210> 203
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(18)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 203
acacataaag cgccctgg                                                     18


<210> 204
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (5)..(12)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (13)..(16)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 204
cacataaagc gccctg                                                       16


<210> 205
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(11)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (12)..(16)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 205
cacataaagc gccctg                                                       16


<210> 206
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(17)
<223> cMe modified nucleoside

<400> 206
acacataaag cgccctg                                                      17


<210> 207
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(17)
<223> cMe modified nucleoside

<400> 207
acacataaag cgccctg                                                      17


<210> 208
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 208
cacataaagc gccctg                                                       16


<210> 209
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(12)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (13)..(16)
<223> cMe modified nucleoside

<400> 209
cacataaagc gccctg                                                       16


<210> 210
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'OMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 210
cacataaagc gccctg                                                       16


<210> 211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 211
actgagataa atacagttcc                                                   20


<210> 212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (7)..(14)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (15)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 212
actgagataa atacagttcc                                                   20


<210> 213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(7)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (8)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 213
actgagataa atacagttcc                                                   20


<210> 214
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (5)..(14)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (15)..(18)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 214
ctgagataaa tacagttc                                                     18


<210> 215
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(18)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 215
ctgagataaa tacagttc                                                     18


<210> 216
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (5)..(12)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (13)..(16)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 216
tgagataaat acagtt                                                       16


<210> 217
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(11)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (12)..(16)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 217
tgagataaat acagtt                                                       16


<210> 218
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(17)
<223> cMe modified nucleoside

<400> 218
ctgagataaa tacagtt                                                      17


<210> 219
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(17)
<223> cMe modified nucleoside

<400> 219
ctgagataaa tacagtt                                                      17


<210> 220

<400> 220
000


<210> 221
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(12)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (13)..(16)
<223> cMe modified nucleoside

<400> 221
tgagataaat acagtt                                                       16


<210> 222
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'OMe modified nucleoside

<220>
<221> modified_base
<222> (6)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 222
tgagataaat acagtt                                                       16


<210> 223
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (5)..(14)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (15)..(18)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 223
ttcttgagca gtaattca                                                     18


<210> 224
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (5)..(14)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (15)..(18)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 224
ttcttgagca gttattca                                                     18


<210> 225
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 225
cttgagcagt aattca                                                       16


<210> 226
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 226
cttgagcagt tattca                                                       16


<210> 227
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cMe modified nucleoside

<220>
<221> modified_base
<222> (4)..(5)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'OMe modified nucleoside

<220>
<221> modified_base
<222> (7)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cMe modified nucleoside

<400> 227
cttgagcagt aattca                                                       16


<210> 228
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 228
aacacgtcta tacgc                                                        15


<210> 229

<400> 229
000


<210> 230
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'F-ANA modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> 2'F-ANA modified nucleoside

<400> 230
tcgcctctaa tttaag                                                       16


<210> 231
<211> 575
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 231
atacatgtgg agattaagac ccataataac aatgacaaca ctttcataac agttcatctg       60

tgttaacata caaattctcg cagcaacact ccagggcgct ttatgtgtgg atctttttta      120

gtctgcatat taaccctaca agttggaaat ggctcctctc aaacactgga gatagagcag      180

cccaaatgta tctgctactg tggtgccttc cataatgcaa aactctctga ggagctgaga      240

atatgtctac tgctaccaaa attgtaaccc ccatcatcta gtaaagagtt ggtacacggt      300

gaacatttgc tgtgggaatg tattctgctt cattccagag gcctgccaat tcttaatctc      360

actataggct gaagagctgc tcacatagaa tacttgtagt gacttccatt ttcaccagtt      420

tagatcagtg gacagagaga tgctgaatta ctgctcaaga agtatagatc cacatgcctt      480

caacttcaga atcttaaatt agaggcgaat gttgagtcta ctaaactgta tagtctgtaa      540

aggcaggaac tgtatttatc tcagtcatat ttaat                                 575


<210> 232
<211> 222
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 232
gttacatgta gagatggaaa cttgcaataa caatggatca aaccctcaca atgctagctg       60

tcaccatatt aggctagatg atagaaacat gtgaataact gctcaagaaa atatagaacc      120

acatcctttg aaattcagaa gcttcaactg ggagggctct tgagcctgct ggactgtata      180

ctctgtaaaa acagaactgt cttcgtctca ctcactattt ta                         222


<210> 233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 233
ctctggaatg aagcagaata                                                   20


<210> 234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 234
gctctatctc cagtgtttga                                                   20


<210> 235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 235
gaatgaagca gaatacattc                                                   20


<210> 236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 236
atttgggctg ctctatctcc                                                   20


<210> 237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 237
tgtgagcagc tcttcagcct                                                   20


<210> 238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 238
acttgtaggg ttaatatgca                                                   20


<210> 239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 239
gcctatagtg agattaagaa                                                   20


<210> 240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 240
tagcagatac atttgggctg                                                   20


<210> 241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 241
cagcctatag tgagattaag                                                   20


<210> 242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 242
aaactggtga aaatggaagt                                                   20


<210> 243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 243
cattatggaa ggcaccacag                                                   20


<210> 244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 244
atgcagacta aaaaagatcc                                                   20


<210> 245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 245
cagaatacat tcccacagca                                                   20


<210> 246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 246
caacttgtag ggttaatatg                                                   20


<210> 247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 247
cagagagttt tgcattatgg                                                   20


<210> 248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 248
gagccatttc caacttgtag                                                   20


<210> 249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 249
ctaaaaaaga tccacacata                                                   20


<210> 250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 250
gtagacatat tctcagctcc                                                   20


<210> 251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 251
aaggcaccac agtagcagat                                                   20


<210> 252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 252
agagttttgc attatggaag                                                   20


<210> 253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 253
tggaaggcac cacagtagca                                                   20


<210> 254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 254
tctccagtgt ttgagaggag                                                   20


<210> 255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 255
ctgctctatc tccagtgttt                                                   20


<210> 256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 256
agatgaactg ttatgaaagt                                                   20


<210> 257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 257
tgaactgtta tgaaagtgtt                                                   20


<210> 258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 258
gtcactacaa gtattctatg                                                   20


<210> 259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 259
gaagcagaat acattcccac                                                   20


<210> 260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 260
atgaagcaga atacattccc                                                   20


<210> 261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 261
caagtattct atgtgagcag                                                   20


<210> 262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 262
tttgggctgc tctatctcca                                                   20


<210> 263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 263
ttgtagggtt aatatgcaga                                                   20


<210> 264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 264
agtagacata ttctcagctc                                                   20


<210> 265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 265
ggcaggcctc tggaatgaag                                                   20


<210> 266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 266
ttctatgtga gcagctcttc                                                   20


<210> 267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 267
gaggagccat ttccaacttg                                                   20


<210> 268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 268
tcagagagtt ttgcattatg                                                   20


<210> 269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 269
tcctcagaga gttttgcatt                                                   20


<210> 270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 270
tatctccagt gtttgagagg                                                   20


<210> 271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 271
ccaacttgta gggttaatat                                                   20


<210> 272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 272
gatacatttg ggctgctcta                                                   20


<210> 273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 273
ttgtcattgt tattatgggt                                                   20


<210> 274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 274
tatgaaagtg ttgtcattgt                                                   20


<210> 275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 275
tgatctaaac tggtgaaaat                                                   20


<210> 276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 276
catattctca gctcctcaga                                                   20


<210> 277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 277
agaggagcca tttccaactt                                                   20


<210> 278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 278
gaaggcacca cagtagcaga                                                   20


<210> 279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 279
catttgggct gctctatctc                                                   20


<210> 280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 280
gaaaatggaa gtcactacaa                                                   20


<210> 281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 281
ctctctgtcc actgatctaa                                                   20


<210> 282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 282
agagagtttt gcattatgga                                                   20


<210> 283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 283
tccactgatc taaactggtg                                                   20


<210> 284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 284
gccatttcca acttgtaggg                                                   20


<210> 285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 285
gtttgagagg agccatttcc                                                   20


<210> 286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 286
gagcagctct tcagcctata                                                   20


<210> 287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 287
cttgtagggt taatatgcag                                                   20


<210> 288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 288
ttgagaggag ccatttccaa                                                   20


<210> 289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 289
ctcctcagag agttttgcat                                                   20


<210> 290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 290
tagcagtaga catattctca                                                   20


<210> 291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 291
gagttttgca ttatggaagg                                                   20


<210> 292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 292
aacttgtagg gttaatatgc                                                   20


<210> 293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 293
gtccactgat ctaaactggt                                                   20


<210> 294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 294
gtagggttaa tatgcagact                                                   20


<210> 295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<220>
<221> modified_base
<222> (6)..(15)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-methoxyethyl (MOE) modified nucleoside

<400> 295
agctcttcag cctatagtga                                                   20


<210> 296
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cET modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cET modified nucleoside

<400> 296
tcttgagcag taattc                                                       16


<210> 297
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> cET modified nucleoside

<220>
<221> modified_base
<222> (4)..(13)
<223> 2'-deoxynucleosides

<220>
<221> modified_base
<222> (14)..(16)
<223> cET modified nucleoside

<400> 297
cagactatac agttta                                                       16


