                         SEQUENCE LISTING

<110>  Chemical & Biopharmaceutical Laboratories of Patras S.A.
 
<120>  PROCESS

<130>  P119807PCT

<140>  PCT/IB2021/060271
<141>  2021-11-05

<150>  GR20200100690
<151>  2020-11-20

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-EGF(1-53)-OH


<220>
<221>  DISULFID
<222>  (6)..(6)
<223>  C6-C20

<220>
<221>  DISULFID
<222>  (14)..(14)
<223>  C14-C31

<220>
<221>  DISULFID
<222>  (20)..(20)
<223>  C6-C20

<220>
<221>  DISULFID
<222>  (31)..(31)
<223>  C14-C31

<220>
<221>  DISULFID
<222>  (33)..(33)
<223>  C33-C42

<220>
<221>  DISULFID
<222>  (42)..(42)
<223>  C33-C42

<400>  1

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
1               5                   10                  15      


Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn 
            20                  25                  30          


Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys 
        35                  40                  45              


Trp Trp Glu Leu Arg 
    50              


<210>  2
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(1-18)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<400>  2

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
1               5                   10                  15      


Asp Gly 
        


<210>  3
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-EGF(19-53)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<400>  3

Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn Cys Val 
1               5                   10                  15      


Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys Trp Trp 
            20                  25                  30          


Glu Leu Arg 
        35  


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(1-12)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Psi-Ser

<400>  4

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly 
1               5                   10          


<210>  5
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-EGF(13-53)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<400>  5

Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys 
1               5                   10                  15      


Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr 
            20                  25                  30          


Arg Asp Leu Lys Trp Trp Glu Leu Arg 
        35                  40      


<210>  6
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-TGF(1-50)-OH

<400>  6

Val Val Ser His Phe Asn Asp Cys Pro Asp Ser His Thr Gln Phe Cys 
1               5                   10                  15      


Phe His Gly Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys 
            20                  25                  30          


Val Cys His Ser Gly Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu 
        35                  40                  45              


Leu Ala 
    50  


<210>  7
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-TGF(1-19)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<400>  7

Val Val Ser His Phe Asn Asp Cys Pro Asp Ser His Thr Gln Phe Cys 
1               5                   10                  15      


Phe His Gly 
            


<210>  8
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-TGF(20-50)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<400>  8

Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys Val Cys His 
1               5                   10                  15      


Ser Gly Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu Leu Ala 
            20                  25                  30      


<210>  9
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-EGF(1-53)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  Side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(14)
<223>  Side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (16)..(17)
<223>  Side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (27)..(29)
<223>  Side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (31)..(33)
<223>  Side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (40)..(46)
<223>  Side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (48)..(51)
<223>  Side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Side chain protecting group

<400>  9

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
1               5                   10                  15      


Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn 
            20                  25                  30          


Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys 
        35                  40                  45              


Trp Trp Glu Leu Arg 
    50              


<210>  10
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(1-18)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(14)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (16)..(17)
<223>  side chain protecting group

<400>  10

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
1               5                   10                  15      


Asp Gly 
        


<210>  11
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-EGF(19-53)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(11)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(15)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (22)..(28)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (30)..(33)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<400>  11

Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn Cys Val 
1               5                   10                  15      


Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys Trp Trp 
            20                  25                  30          


Glu Leu Arg 
        35  


<210>  12
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-EGF(1-53)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Trt side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  tBu side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  tBu side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Trt side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Trt side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  tBu side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  tBu side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Trt side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Trt side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  tBu side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Trt side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  tBu side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  tBu side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  tBu side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Boc side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  tBu side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (31)..(33)
<223>  Trt side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  tBu side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  tBu side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Pbf side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (42)..(43)
<223>  Trt side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  tBu side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Pbf side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  tBu side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (48)..(50)
<223>  Boc side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  tBu side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Pbf side chain protecting group

<400>  12

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
1               5                   10                  15      


Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn 
            20                  25                  30          


Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys 
        35                  40                  45              


Trp Trp Glu Leu Arg 
    50              


<210>  13
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(1-18)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  tBu protecting group

<400>  13

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
1               5                   10                  15      


Asp Gly 
        


<210>  14
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-EGF(19-53)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Boc protecting group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(15)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Pbf protecting group

<220>
<221>  MISC_FEATURE
<222>  (24)..(25)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Pbf protecting group

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (30)..(32)
<223>  Boc protecting group

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Pbf protecting group

<400>  14

Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn Cys Val 
1               5                   10                  15      


Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys Trp Trp 
            20                  25                  30          


Glu Leu Arg 
        35  


<210>  15
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(1-18)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(14)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (16)..(17)
<223>  side chain protecting group

<400>  15

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
1               5                   10                  15      


Asp Gly 
        


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(1-12)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  side chain protecting group

<400>  16

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly 
1               5                   10          


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-EGF(13-18)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<400>  17

Tyr Cys Leu His Asp Gly 
1               5       


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(1-12)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  tBu protecting group

<400>  18

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly 
1               5                   10          


<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-EGF(13-18)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<400>  19

Tyr Cys Leu His Asp Gly 
1               5       


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(1-12)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  Side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Side chain protecting group

<400>  20

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly 
1               5                   10          


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(1-12)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  tBu protecting group

<400>  21

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly 
1               5                   10          


<210>  22
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(19-36)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(11)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(15)
<223>  side chain protecting group

<400>  22

Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn Cys Val 
1               5                   10                  15      


Val Gly 
        


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-EGF(37-53)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(10)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (12)..(15)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  side chain protecting group

<400>  23

Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu 
1               5                   10                  15      


Arg 
    


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(19-36)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Boc protecting group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(15)
<223>  Trt protecting group

<400>  24

Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn Cys Val 
1               5                   10                  15      


Val Gly 
        


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-EGF(37-53)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Pbf protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Pbf protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  Boc protecting group

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Pbf protecting group

<400>  25

Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu 
1               5                   10                  15      


Arg 
    


<210>  26
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(19-36)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(11)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(15)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  side chain protecting group

<400>  26

Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn Cys Val 
1               5                   10                  15      


Val Gly Tyr Ile Gly 
            20      


<210>  27
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-EGF(40-53)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(12)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<400>  27

Glu Arg Cys Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg 
1               5                   10                  


<210>  28
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(19-36)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Boc protecting group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(15)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  side chain protecting group

<400>  28

Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn Cys Val 
1               5                   10                  15      


Val Gly Tyr Ile Gly 
            20      


<210>  29
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-EGF(40-53)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Pbf protecting group

<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Pbf protecting group

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(11)
<223>  Boc protecting group

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Pbf protecting group

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<400>  29

Glu Arg Cys Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg 
1               5                   10                  


<210>  30
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(37-39)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  side chain protecting group

<400>  30

Tyr Ile Gly 
1           


<210>  31
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(37-39)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tBu protecting group

<400>  31

Tyr Ile Gly 
1           


<210>  32
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-EGF(13-53)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  protecting side group

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  protecting side group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  protecting side group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  protecting side group

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  protecting side group

<220>
<221>  MISC_FEATURE
<222>  (15)..(17)
<223>  protecting side group

<220>
<221>  MISC_FEATURE
<222>  (19)..(21)
<223>  protecting side group

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  protecting side group

<220>
<221>  MISC_FEATURE
<222>  (28)..(34)
<223>  protecting side group

<220>
<221>  MISC_FEATURE
<222>  (36)..(39)
<223>  protecting side group

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  protecting side group

<400>  32

Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys 
1               5                   10                  15      


Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr 
            20                  25                  30          


Arg Asp Leu Lys Trp Trp Glu Leu Arg 
        35                  40      


<210>  33
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-EGF(13-53)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tBu protecting side group

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Trt protecting side group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Trt protecting side group

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  tBu protecting side group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Trt protecting side group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  tBu protecting side group

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  tBu protecting side group

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  tBu protecting side group

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Boc protecting side group

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  tBu protecting side group

<220>
<221>  MISC_FEATURE
<222>  (19)..(21)
<223>  Trt protecting side group

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  tBu protecting side group

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  tBu protecting side group

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Pbf protecting side group

<220>
<221>  MISC_FEATURE
<222>  (30)..(31)
<223>  Trt protecting side group

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  tBu protecting side group

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Pbf protecting side group

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  tBu protecting side group

<220>
<221>  MISC_FEATURE
<222>  (36)..(38)
<223>  Boc protecting side group

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  tBu protecting side group

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Pbf protecting side group

<400>  33

Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys 
1               5                   10                  15      


Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr 
            20                  25                  30          


Arg Asp Leu Lys Trp Trp Glu Leu Arg 
        35                  40      


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(1-12)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  Side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Side chain protecting group

<400>  34

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly 
1               5                   10          


<210>  35
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(13-36)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc or Fmoc

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  protecting side chain

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  protecting side chain

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  protecting side chain

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  protecting side chain

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  protecting side chain

<220>
<221>  MISC_FEATURE
<222>  (15)..(17)
<223>  protecting side chain

<220>
<221>  MISC_FEATURE
<222>  (19)..(21)
<223>  protecting side chain

<400>  35

Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys 
1               5                   10                  15      


Tyr Ala Cys Asn Cys Val Val Gly 
            20                  


<210>  36
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-EGF(13-36)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc or Fmoc

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tBu side chain

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Trt side chain

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Trt side chain

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  tBu side chain

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Trt side chain

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  tBu side chain

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  tBu side chain

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  tBu side chain

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Boc side chain

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  tBu side chain

<220>
<221>  MISC_FEATURE
<222>  (19)..(21)
<223>  Trt side chain

<400>  36

Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys 
1               5                   10                  15      


Tyr Ala Cys Asn Cys Val Val Gly 
            20                  


<210>  37
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-TGF(1-50)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc or Fmoc

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<400>  37

Val Val Ser His Phe Asn Asp Cys Pro Asp Ser His Thr Gln Phe Cys 
1               5                   10                  15      


Phe His Gly Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys 
            20                  25                  30          


Val Cys His Ser Gly Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu 
        35                  40                  45              


Leu Ala 
    50  


<210>  38
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-TGF(1-19)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc or Fmoc

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  side chain protecting group

<400>  38

Val Val Ser His Phe Asn Asp Cys Pro Asp Ser His Thr Gln Phe Cys 
1               5                   10                  15      


Phe His Gly 
            


<210>  39
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-TGF(20-50)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<400>  39

Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys Val Cys His 
1               5                   10                  15      


Ser Gly Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu Leu Ala 
            20                  25                  30      


<210>  40
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-TGF(1-50)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc or Fmoc

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Pbf protecting group

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Boc protecting group

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Pbf protecting group

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<400>  40

Val Val Ser His Phe Asn Asp Cys Pro Asp Ser His Thr Gln Phe Cys 
1               5                   10                  15      


Phe His Gly Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys 
            20                  25                  30          


Val Cys His Ser Gly Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu 
        35                  40                  45              


Leu Ala 
    50  


<210>  41
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-TGF(1-19)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc or Fmoc

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Trt protecting group

<400>  41

Val Val Ser His Phe Asn Asp Cys Pro Asp Ser His Thr Gln Phe Cys 
1               5                   10                  15      


Phe His Gly 
            


<210>  42
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-TGF(20-50)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Pbf protecting group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Boc protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Pbf protecting group

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<400>  42

Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys Val Cys His 
1               5                   10                  15      


Ser Gly Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu Leu Ala 
            20                  25                  30      


<210>  43
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-TGF(20-37)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  side chain protecting group

<400>  43

Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys Val Cys His 
1               5                   10                  15      


Ser Gly 
        


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-TGF(38-50)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<400>  44

Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu Leu Ala 
1               5                   10              


<210>  45
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-TGF(20-50)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Pbf protecting group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Boc protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Pbf protecting group

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<400>  45

Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys Val Cys His 
1               5                   10                  15      


Ser Gly Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu Leu Ala 
            20                  25                  30      


<210>  46
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG1-TGF(20-37)-OH


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal protecting group selected from Boc and Fmoc

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Pbf protecting group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Boc protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  tBu protecting group

<400>  46

Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys Val Cys His 
1               5                   10                  15      


Ser Gly 
        


<210>  47
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-TGF(38-50)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Pbf protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<400>  47

Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu Leu Ala 
1               5                   10              


<210>  48
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-TGF(38-50)-OPG2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  C-terminal protecting group selected from chlorotrityl and 
       t-butyl

<400>  48

Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu Leu Ala 
1               5                   10              


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Generic


<220>
<221>  DISULFID
<222>  (1)..(1)
<223>  C1-C3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  (X)7, where each X is independently a natural or unnatural amino 
       acid

<220>
<221>  DISULFID
<222>  (3)..(3)
<223>  C2-C4

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  (X)4-5, where each X is independently a natural or unnatural 
       amino acid

<220>
<221>  DISULFID
<222>  (5)..(5)
<223>  C1-C3

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  (X)10-13, where each X is independently a natural or unnatural 
       amino acid

<220>
<221>  DISULFID
<222>  (7)..(7)
<223>  C2-C4

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  (X), where each X is independently a natural or unnatural amino 
       acid

<220>
<221>  DISULFID
<222>  (9)..(9)
<223>  C5-C6

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  (X)8, where each X is independently a natural or unnatural amino 
       acid

<220>
<221>  DISULFID
<222>  (11)..(11)
<223>  C5-C6

<400>  49

Cys Xaa Cys Xaa Cys Xaa Cys Xaa Cys Xaa Cys 
1               5                   10      


<210>  50
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-TGF(1-50)-OH


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  side chain protecting group

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  side chain protecting group

<400>  50

Val Val Ser His Phe Asn Asp Cys Pro Asp Ser His Thr Gln Phe Cys 
1               5                   10                  15      


Phe His Gly Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys 
            20                  25                  30          


Val Cys His Ser Gly Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu 
        35                  40                  45              


Leu Ala 
    50  


<210>  51
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-TGF(1-50)-OH


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Psi-Ser

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Pbf protecting group

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Boc protecting group

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Pbf protecting group

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  tBu protecting group

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Trt protecting group

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  tBu protecting group

<400>  51

Val Val Ser His Phe Asn Asp Cys Pro Asp Ser His Thr Gln Phe Cys 
1               5                   10                  15      


Phe His Gly Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys 
            20                  25                  30          


Val Cys His Ser Gly Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu 
        35                  40                  45              


Leu Ala 
    50  


