                               SEQUENCE LISTING

<110> 2692372 ONTARIO, INC.
      DUNAD THERAPEUTICS LTD.
 
<120> METHODS AND COMPOSITIONS FOR KRAS MODIFICATIONS

<130> 59091-704.601

<140>
<141>

<150> 63/116,723
<151> 2020-11-20

<160> 3     

<170> PatentIn version 3.5

<210> 1
<211> 187
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      KRAS G12C In-House sequence

<400> 1
Met His His His His His His Ser Ser Gly Arg Glu Asn Leu Tyr Phe 
1               5                   10                  15      


Gln Gly Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Cys Gly Val 
            20                  25                  30          


Gly Lys Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp 
        35                  40                  45              


Glu Tyr Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile 
    50                  55                  60                  


Asp Gly Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu 
65                  70                  75                  80  


Glu Tyr Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe 
                85                  90                  95      


Leu Cys Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His 
            100                 105                 110         


His Tyr Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro 
        115                 120                 125             


Met Val Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp 
    130                 135                 140                 


Thr Lys Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile 
145                 150                 155                 160 


Glu Thr Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr 
                165                 170                 175     


Leu Val Arg Glu Ile Arg Lys His Lys Glu Lys 
            180                 185         


<210> 2
<211> 186
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      KRAS G12C Commercial sequence

<400> 2
His His His His His His Ser Ser Gly Arg Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      


Gly Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Cys Gly Val Gly 
            20                  25                  30          


Lys Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu 
        35                  40                  45              


Tyr Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp 
    50                  55                  60                  


Gly Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu 
65                  70                  75                  80  


Tyr Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu 
                85                  90                  95      


Cys Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His 
            100                 105                 110         


Tyr Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met 
        115                 120                 125             


Val Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr 
    130                 135                 140                 


Lys Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu 
145                 150                 155                 160 


Thr Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu 
                165                 170                 175     


Val Arg Glu Ile Arg Lys His Lys Glu Lys 
            180                 185     


<210> 3
<211> 187
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      KRAS Lite sequence

<400> 3
Met His His His His His His Ser Ser Gly Arg Glu Asn Leu Tyr Phe 
1               5                   10                  15      


Gln Gly Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Cys Gly Val 
            20                  25                  30          


Gly Lys Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp 
        35                  40                  45              


Glu Tyr Asp Pro Thr Ile Glu Asp Cys Tyr Arg Lys Gln Val Val Ile 
    50                  55                  60                  


Asp Gly Glu Thr Ser Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu 
65                  70                  75                  80  


Glu Tyr Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe 
                85                  90                  95      


Leu Ser Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His 
            100                 105                 110         


His Tyr Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro 
        115                 120                 125             


Met Val Leu Val Gly Asn Lys Ser Asp Leu Pro Ser Arg Thr Val Asp 
    130                 135                 140                 


Thr Lys Gln Ala Gln Asp Leu Ala Arg Pro Tyr Gly Ile Pro Phe Ile 
145                 150                 155                 160 


Glu Thr Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr 
                165                 170                 175     


Leu Val Arg Glu Ile Arg Lys His Lys Glu Lys 
            180                 185         


