                               SEQUENCE LISTING

<110> CHULABHORN FOUNDATION
 
<120> ERYTHROPOIETIN VARIANTS AND USES THEREOF

<130> C2238-7000WO

<140>
<141>

<150> 63/115,208
<151> 2020-11-18

<160> 46    

<170> PatentIn version 3.5

<210> 1
<211> 166
<212> PRT
<213> Homo sapiens

<400> 1
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 2
<211> 564
<212> DNA
<213> Homo sapiens

<400> 2
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtgctggaaa gatacctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcct ggcgctgctg tccgaggccg tgctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

gggctccgca gcctgaccac cctgctgcgg gccttgggcg cgcaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtactccaa cttcctccgg ggaaagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 3
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Val Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Val Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 4
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 4
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtgctggaaa gatacctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcgt ggcgctgctg tccgaggccg tgctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

ggggtccgca gcctgaccac cctgctgcgg gccttgggcg cgcaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtactccaa cttcctccgg ggaaagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 5
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Val Ser Glu Ala Leu Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Ile Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 6
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 6
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtgctggaaa gatacctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcct ggcgctggtg tccgaggccc tgctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

gggattcgca gcctgaccac cctgcttcgg gccttgggcg cgcaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtactccaa cttcctccgg ggaaagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 7
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Thr Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 8
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 8
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtgctggaaa gatacctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcct ggcgctgctg tccgaggccg tgctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

gggacccgca gcctgaccac cctgctgcgg gccttgggcg cgcaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtactccaa cttcctccgg ggaaagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 9
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Asn Ala Leu Leu Ser Glu Ala Asn Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Asp Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 10
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 10
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtgctggaaa gatacctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcaa cgcgctgctg tccgaggcca acctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

ggggatcgca gcctgaccac cctgctgcgg gccttgggcg cgcaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtactccaa cttcctccgg ggaaagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 11
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Asp Ala Leu Leu Ser Glu Ala Asp Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Asn Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 12
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 12
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtgctggaaa gatacctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcga tgcgctgctg tccgaggccg acctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

gggaaccgca gcctgaccac cctgctgcgg gccttgggcg cgcaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtactccaa cttcctccgg ggaaagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 13
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Ala Glu Arg Ile Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Phe Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Trp Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 14
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 14
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtggcggaaa gaatcctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcct ggcgctgctg tccgaggccg tgctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

gggctccgca gcttcaccac cctgctgcgg gccttgggcg cgcaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtactccaa cttctggcgg ggaaagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 15
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Ile Glu Arg Trp Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Ser Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Val Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 16
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 16
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtgatcgaaa gatggctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcct ggcgctgctg tccgaggccg tgctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

gggctccgca gctccaccac cctgctgcgg gccttgggcg cgcaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtactccaa cttcgtgcgg ggaaagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 17
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Phe Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 18
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 18
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtgctggaaa gatacctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcct ggcgctgctg tccgaggccg tgctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

gggctccgca gcttcaccac cctgctgcgg gccttgggcg cgcaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtactccaa cttcctccgg ggaaagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 19
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 19
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Ala Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 20
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 20
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtgctggaaa gatacctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcct ggcgctgctg tccgaggccg tgctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

gggctccgca gcctggccac cctgctgcgg gccttgggcg cgcaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtactccaa cttcctccgg ggaaagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 21
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Gly Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 22
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 22
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtgctggaaa gatacctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcct ggcgctgctg tccgaggccg tgctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

gggctccgca gcctgggcac cctgctgcgg gccttgggcg cgcaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtactccaa cttcctccgg ggaaagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 23
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 23
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu His Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 24
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 24
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtgctggaaa gatacctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcct ggcgctgctg tccgaggccg tgctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

gggctccgca gcctgcacac cctgctgcgg gccttgggcg cgcaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtactccaa cttcctccgg ggaaagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 25
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Ala Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 26
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 26
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtgctggaaa gatacctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcct ggcgctgctg tccgaggccg tgctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

gggctccgca gcctgaccac cctggcgcgg gccttgggcg cgcaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtactccaa cttcctccgg ggaaagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 27
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 27
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Trp Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 28
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 28
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtgctggaaa gatacctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcct ggcgctgctg tccgaggccg tgctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

gggctccgca gcctgaccac cctgtggcgg gccttgggcg cgcaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtactccaa cttcctccgg ggaaagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 29
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 29
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Cys Arg Ala Leu 
            100                 105                 110         


Gly Cys Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 30
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 30
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtgctggaaa gatacctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcct ggcgctgctg tccgaggccg tgctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

gggctccgca gcctgaccac cctgtgtcgg gccttgggct gccaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtactccaa cttcctccgg ggaaagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 31
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 31
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Thr Arg Ser Ser His Thr Leu Trp Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 32
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 32
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtgctggaaa gatacctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcct ggcgctgctg tccgaggccg tgctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

gggacccgca gctcccacac cctgtggcgg gccttgggcg cgcaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtactccaa cttcctccgg ggaaagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 33
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Thr Arg Ser Ser Gly Thr Leu Trp Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 34
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 34
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtgctggaaa gatacctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcct ggcgctgctg tccgaggccg tgctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

gggacccgca gctccggcac cctgtggcgg gccttgggcg cgcaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtactccaa cttcctccgg ggaaagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 35
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 35
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Asn Asn Phe Leu Arg Gly Gln Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 36
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 36
atggaaaccg atactctgct gctctgggtc cttctgcttt gggtgcctgg ttcgactgga       60

gctccgcctc ggttgatctg cgactcccgc gtgctggaaa gatacctcct ggaagccaaa      120

gaggccgaga acatcaccac cggttgtgcc gagcattgct ccctgaacga aaacattacc      180

gtgcccgaca ccaaggtcaa cttctacgct tggaagcgga tggaagtcgg ccagcaggcc      240

gtggaggtct ggcagggcct ggcgctgctg tccgaggccg tgctcagggg acaagcactc      300

ctcgtgaata gctcgcagcc ctgggaaccg ctgcagctgc acgtggataa ggctgtgtca      360

gggctccgca gcctgaccac cctgctgcgg gccttgggcg cgcaaaagga agccatctcc      420

cccccggacg ccgccagcgc agcgccactg aggactatta ccgccgacac attccgcaag      480

ctgtttcggg tgtacaacaa cttcctccgg ggacagctga agctgtacac tggagaggcc      540

tgcagaacgg gggaccgcta atga                                             564


<210> 37
<211> 9
<212> PRT
<213> Homo sapiens

<400> 37
Val Leu Arg Gly Gln Ala Leu Leu Val 
1               5                   


<210> 38
<211> 9
<212> PRT
<213> Homo sapiens

<400> 38
Leu Arg Ser Leu Thr Thr Leu Leu Arg 
1               5                   


<210> 39
<211> 9
<212> PRT
<213> Homo sapiens

<400> 39
Leu Leu Arg Ala Leu Gly Ala Gln Lys 
1               5                   


<210> 40
<211> 9
<212> PRT
<213> Homo sapiens

<400> 40
Phe Arg Val Tyr Ser Asn Phe Leu Arg 
1               5                   


<210> 41
<211> 9
<212> PRT
<213> Homo sapiens

<400> 41
Tyr Ser Asn Phe Leu Arg Gly Lys Leu 
1               5                   


<210> 42
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (12)..(12)
<223> /replace="A" or "I"

<220>
<221> VARIANT
<222> (15)..(15)
<223> /replace="I" or "W"

<220>
<221> VARIANT
<222> (67)..(67)
<223> /replace="D", "N", or "V"

<220>
<221> VARIANT
<222> (70)..(70)
<223> /replace="V"

<220>
<221> VARIANT
<222> (74)..(74)
<223> /replace="D", "L", or "N"

<220>
<221> VARIANT
<222> (102)..(102)
<223> /replace="D", "I", "N", "T", or "V"

<220>
<221> VARIANT
<222> (105)..(105)
<223> /replace="F" or "S"

<220>
<221> VARIANT
<222> (106)..(106)
<223> /replace="A", "G", or "H"

<220>
<221> VARIANT
<222> (109)..(109)
<223> /replace="A", "C", or "W"

<220>
<221> VARIANT
<222> (114)..(114)
<223> /replace="C"

<220>
<221> VARIANT
<222> (146)..(146)
<223> /replace="N"

<220>
<221> VARIANT
<222> (149)..(149)
<223> /replace="V" or "W"

<220>
<221> VARIANT
<222> (152)..(152)
<223> /replace="Q" 

<220>
<221> SITE
<222> (1)..(166)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 42
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210> 43
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 43
His His His His His His 
1               5       


<210> 44
<211> 15
<212> PRT
<213> Homo sapiens

<400> 44
Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys 
1               5                   10                  15  


<210> 45
<211> 12
<212> PRT
<213> Homo sapiens

<400> 45
Phe Arg Val Tyr Ser Asn Phe Leu Arg Gly Lys Leu 
1               5                   10          


<210> 46
<211> 166
<212> PRT
<213> Homo sapiens

<400> 46
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Lys Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Lys Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Lys Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Asn Ser Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


