               SEQUENCE LISTING

<110> MedImmune Limited

<120> Molecules

<130> PROTAC-100-PCT-PSP

<160> 281

<170> BiSSAP 1.3.6

<210> 1
<211> 152
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2A E2 domain

<400> 1
Met Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Leu 
1               5                   10                  15      
Gln Glu Asp Pro Pro Ala Gly Val Ser Gly Ala Pro Ser Glu Asn Asn 
            20                  25                  30          
Ile Met Val Trp Asn Ala Val Ile Phe Gly Pro Glu Gly Thr Pro Phe 
        35                  40                  45              
Glu Asp Gly Thr Phe Lys Leu Thr Ile Glu Phe Thr Glu Glu Tyr Pro 
    50                  55                  60                  
Asn Lys Pro Pro Thr Val Arg Phe Val Ser Lys Met Phe His Pro Asn 
65                  70                  75                  80  
Val Tyr Ala Asp Gly Ser Ile Cys Leu Asp Ile Leu Gln Asn Arg Trp 
                85                  90                  95      
Ser Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr Ser Ile Gln Ser Leu 
            100                 105                 110         
Leu Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn Ser Gln Ala Ala Gln 
        115                 120                 125             
Leu Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys Arg Val Ser Ala Ile 
    130                 135                 140                 
Val Glu Gln Ser Trp Arg Asp Cys 
145                 150         

<210> 2
<211> 152
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2B E2 domain

<400> 2
Met Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Leu 
1               5                   10                  15      
Gln Glu Asp Pro Pro Val Gly Val Ser Gly Ala Pro Ser Glu Asn Asn 
            20                  25                  30          
Ile Met Gln Trp Asn Ala Val Ile Phe Gly Pro Glu Gly Thr Pro Phe 
        35                  40                  45              
Glu Asp Gly Thr Phe Lys Leu Val Ile Glu Phe Ser Glu Glu Tyr Pro 
    50                  55                  60                  
Asn Lys Pro Pro Thr Val Arg Phe Leu Ser Lys Met Phe His Pro Asn 
65                  70                  75                  80  
Val Tyr Ala Asp Gly Ser Ile Cys Leu Asp Ile Leu Gln Asn Arg Trp 
                85                  90                  95      
Ser Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr Ser Ile Gln Ser Leu 
            100                 105                 110         
Leu Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn Ser Gln Ala Ala Gln 
        115                 120                 125             
Leu Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys Arg Val Ser Ala Ile 
    130                 135                 140                 
Val Glu Gln Ser Trp Asn Asp Ser 
145                 150         

<210> 3
<211> 179
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2C E2 domain

<400> 3
Met Ala Ser Gln Asn Arg Asp Pro Ala Ala Thr Ser Val Ala Ala Ala 
1               5                   10                  15      
Arg Lys Gly Ala Glu Pro Ser Gly Gly Ala Ala Arg Gly Pro Val Gly 
            20                  25                  30          
Lys Arg Leu Gln Gln Glu Leu Met Thr Leu Met Met Ser Gly Asp Lys 
        35                  40                  45              
Gly Ile Ser Ala Phe Pro Glu Ser Asp Asn Leu Phe Lys Trp Val Gly 
    50                  55                  60                  
Thr Ile His Gly Ala Ala Gly Thr Val Tyr Glu Asp Leu Arg Tyr Lys 
65                  70                  75                  80  
Leu Ser Leu Glu Phe Pro Ser Gly Tyr Pro Tyr Asn Ala Pro Thr Val 
                85                  90                  95      
Lys Phe Leu Thr Pro Cys Tyr His Pro Asn Val Asp Thr Gln Gly Asn 
            100                 105                 110         
Ile Cys Leu Asp Ile Leu Lys Glu Lys Trp Ser Ala Leu Tyr Asp Val 
        115                 120                 125             
Arg Thr Ile Leu Leu Ser Ile Gln Ser Leu Leu Gly Glu Pro Asn Ile 
    130                 135                 140                 
Asp Ser Pro Leu Asn Thr His Ala Ala Glu Leu Trp Lys Asn Pro Thr 
145                 150                 155                 160 
Ala Phe Lys Lys Tyr Leu Gln Glu Thr Tyr Ser Lys Gln Val Thr Ser 
                165                 170                 175     
Gln Glu Pro 
            

<210> 4
<211> 147
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2D1 E2 domain

<400> 4
Met Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp 
1               5                   10                  15      
Pro Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His 
            20                  25                  30          
Trp Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly 
        35                  40                  45              
Val Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro 
    50                  55                  60                  
Pro Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser 
65                  70                  75                  80  
Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala 
                85                  90                  95      
Leu Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp 
            100                 105                 110         
Pro Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys 
        115                 120                 125             
Ser Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys 
    130                 135                 140                 
Tyr Ala Met 
145         

<210> 5
<211> 147
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2D2 E2 domain

<400> 5
Met Ala Leu Lys Arg Ile His Lys Glu Leu Asn Asp Leu Ala Arg Asp 
1               5                   10                  15      
Pro Pro Ala Gln Cys Ser Ala Gly Pro Val Gly Asp Asp Met Phe His 
            20                  25                  30          
Trp Gln Ala Thr Ile Met Gly Pro Asn Asp Ser Pro Tyr Gln Gly Gly 
        35                  40                  45              
Val Phe Phe Leu Thr Ile His Phe Pro Thr Asp Tyr Pro Phe Lys Pro 
    50                  55                  60                  
Pro Lys Val Ala Phe Thr Thr Arg Ile Tyr His Pro Asn Ile Asn Ser 
65                  70                  75                  80  
Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala 
                85                  90                  95      
Leu Thr Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp 
            100                 105                 110         
Pro Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala Arg Ile Tyr Lys 
        115                 120                 125             
Thr Asp Arg Glu Lys Tyr Asn Arg Ile Ala Arg Glu Trp Thr Gln Lys 
    130                 135                 140                 
Tyr Ala Met 
145         

<210> 6
<211> 147
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2D3 E2 domain

<400> 6
Met Ala Leu Lys Arg Ile Asn Lys Glu Leu Ser Asp Leu Ala Arg Asp 
1               5                   10                  15      
Pro Pro Ala Gln Cys Ser Ala Gly Pro Val Gly Asp Asp Met Phe His 
            20                  25                  30          
Trp Gln Ala Thr Ile Met Gly Pro Asn Asp Ser Pro Tyr Gln Gly Gly 
        35                  40                  45              
Val Phe Phe Leu Thr Ile His Phe Pro Thr Asp Tyr Pro Phe Lys Pro 
    50                  55                  60                  
Pro Lys Val Ala Phe Thr Thr Arg Ile Tyr His Pro Asn Ile Asn Ser 
65                  70                  75                  80  
Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala 
                85                  90                  95      
Leu Thr Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp 
            100                 105                 110         
Pro Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala Arg Ile Tyr Lys 
        115                 120                 125             
Thr Asp Arg Asp Lys Tyr Asn Arg Ile Ser Arg Glu Trp Thr Gln Lys 
    130                 135                 140                 
Tyr Ala Met 
145         

<210> 7
<211> 147
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2D4 E2 domain

<400> 7
Met Ala Leu Lys Arg Ile Gln Lys Glu Leu Thr Asp Leu Gln Arg Asp 
1               5                   10                  15      
Pro Pro Ala Gln Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His 
            20                  25                  30          
Trp Gln Ala Thr Ile Met Gly Pro Asn Asp Ser Pro Tyr Gln Gly Gly 
        35                  40                  45              
Val Phe Phe Leu Thr Ile His Phe Pro Thr Asp Tyr Pro Phe Lys Pro 
    50                  55                  60                  
Pro Lys Val Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser 
65                  70                  75                  80  
Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala 
                85                  90                  95      
Leu Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp 
            100                 105                 110         
Pro Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala His Thr Tyr Lys 
        115                 120                 125             
Ala Asp Arg Glu Lys Tyr Asn Arg Leu Ala Arg Glu Trp Thr Gln Lys 
    130                 135                 140                 
Tyr Ala Met 
145         

<210> 8
<211> 193
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2E1 E2 domain

<400> 8
Met Ser Asp Asp Asp Ser Arg Ala Ser Thr Ser Ser Ser Ser Ser Ser 
1               5                   10                  15      
Ser Ser Asn Gln Gln Thr Glu Lys Glu Thr Asn Thr Pro Lys Lys Lys 
            20                  25                  30          
Glu Ser Lys Val Ser Met Ser Lys Asn Ser Lys Leu Leu Ser Thr Ser 
        35                  40                  45              
Ala Lys Arg Ile Gln Lys Glu Leu Ala Asp Ile Thr Leu Asp Pro Pro 
    50                  55                  60                  
Pro Asn Cys Ser Ala Gly Pro Lys Gly Asp Asn Ile Tyr Glu Trp Arg 
65                  70                  75                  80  
Ser Thr Ile Leu Gly Pro Pro Gly Ser Val Tyr Glu Gly Gly Val Phe 
                85                  90                  95      
Phe Leu Asp Ile Thr Phe Thr Pro Glu Tyr Pro Phe Lys Pro Pro Lys 
            100                 105                 110         
Val Thr Phe Arg Thr Arg Ile Tyr His Cys Asn Ile Asn Ser Gln Gly 
        115                 120                 125             
Val Ile Cys Leu Asp Ile Leu Lys Asp Asn Trp Ser Pro Ala Leu Thr 
    130                 135                 140                 
Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Thr Asp Cys Asn 
145                 150                 155                 160 
Pro Ala Asp Pro Leu Val Gly Ser Ile Ala Thr Gln Tyr Met Thr Asn 
                165                 170                 175     
Arg Ala Glu His Asp Arg Met Ala Arg Gln Trp Thr Lys Arg Tyr Ala 
            180                 185                 190         
Thr 
    

<210> 9
<211> 201
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2E2 E2 domain

<400> 9
Met Ser Thr Glu Ala Gln Arg Val Asp Asp Ser Pro Ser Thr Ser Gly 
1               5                   10                  15      
Gly Ser Ser Asp Gly Asp Gln Arg Glu Ser Val Gln Gln Glu Pro Glu 
            20                  25                  30          
Arg Glu Gln Val Gln Pro Lys Lys Lys Glu Gly Lys Ile Ser Ser Lys 
        35                  40                  45              
Thr Ala Ala Lys Leu Ser Thr Ser Ala Lys Arg Ile Gln Lys Glu Leu 
    50                  55                  60                  
Ala Glu Ile Thr Leu Asp Pro Pro Pro Asn Cys Ser Ala Gly Pro Lys 
65                  70                  75                  80  
Gly Asp Asn Ile Tyr Glu Trp Arg Ser Thr Ile Leu Gly Pro Pro Gly 
                85                  90                  95      
Ser Val Tyr Glu Gly Gly Val Phe Phe Leu Asp Ile Thr Phe Ser Pro 
            100                 105                 110         
Asp Tyr Pro Phe Lys Pro Pro Lys Val Thr Phe Arg Thr Arg Ile Tyr 
        115                 120                 125             
His Cys Asn Ile Asn Ser Gln Gly Val Ile Cys Leu Asp Ile Leu Lys 
    130                 135                 140                 
Asp Asn Trp Ser Pro Ala Leu Thr Ile Ser Lys Val Leu Leu Ser Ile 
145                 150                 155                 160 
Cys Ser Leu Leu Thr Asp Cys Asn Pro Ala Asp Pro Leu Val Gly Ser 
                165                 170                 175     
Ile Ala Thr Gln Tyr Met Thr Asn Arg Ala Glu His Asp Arg Met Ala 
            180                 185                 190         
Arg Gln Trp Thr Lys Arg Tyr Ala Thr 
        195                 200     

<210> 10
<211> 207
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2E3 E2 domain

<400> 10
Met Ser Ser Asp Arg Gln Arg Ser Asp Asp Glu Ser Pro Ser Thr Ser 
1               5                   10                  15      
Ser Gly Ser Ser Asp Ala Asp Gln Arg Asp Pro Ala Ala Pro Glu Pro 
            20                  25                  30          
Glu Glu Gln Glu Glu Arg Lys Pro Ser Ala Thr Gln Gln Lys Lys Asn 
        35                  40                  45              
Thr Lys Leu Ser Ser Lys Thr Thr Ala Lys Leu Ser Thr Ser Ala Lys 
    50                  55                  60                  
Arg Ile Gln Lys Glu Leu Ala Glu Ile Thr Leu Asp Pro Pro Pro Asn 
65                  70                  75                  80  
Cys Ser Ala Gly Pro Lys Gly Asp Asn Ile Tyr Glu Trp Arg Ser Thr 
                85                  90                  95      
Ile Leu Gly Pro Pro Gly Ser Val Tyr Glu Gly Gly Val Phe Phe Leu 
            100                 105                 110         
Asp Ile Thr Phe Ser Ser Asp Tyr Pro Phe Lys Pro Pro Lys Val Thr 
        115                 120                 125             
Phe Arg Thr Arg Ile Tyr His Cys Asn Ile Asn Ser Gln Gly Val Ile 
    130                 135                 140                 
Cys Leu Asp Ile Leu Lys Asp Asn Trp Ser Pro Ala Leu Thr Ile Ser 
145                 150                 155                 160 
Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Thr Asp Cys Asn Pro Ala 
                165                 170                 175     
Asp Pro Leu Val Gly Ser Ile Ala Thr Gln Tyr Leu Thr Asn Arg Ala 
            180                 185                 190         
Glu His Asp Arg Ile Ala Arg Gln Trp Thr Lys Arg Tyr Ala Thr 
        195                 200                 205         

<210> 11
<211> 185
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2F E2 domain

<400> 11
Met Leu Thr Leu Ala Ser Lys Leu Lys Arg Asp Asp Gly Leu Lys Gly 
1               5                   10                  15      
Ser Arg Thr Ala Ala Thr Ala Ser Asp Ser Thr Arg Arg Val Ser Val 
            20                  25                  30          
Arg Asp Lys Leu Leu Val Lys Glu Val Ala Glu Leu Glu Ala Asn Leu 
        35                  40                  45              
Pro Cys Thr Cys Lys Val His Phe Pro Asp Pro Asn Lys Leu His Cys 
    50                  55                  60                  
Phe Gln Leu Thr Val Thr Pro Asp Glu Gly Tyr Tyr Gln Gly Gly Lys 
65                  70                  75                  80  
Phe Gln Phe Glu Thr Glu Val Pro Asp Ala Tyr Asn Met Val Pro Pro 
                85                  90                  95      
Lys Val Lys Cys Leu Thr Lys Ile Trp His Pro Asn Ile Thr Glu Thr 
            100                 105                 110         
Gly Glu Ile Cys Leu Ser Leu Leu Arg Glu His Ser Ile Asp Gly Thr 
        115                 120                 125             
Gly Trp Ala Pro Thr Arg Thr Leu Lys Asp Val Val Trp Gly Leu Asn 
    130                 135                 140                 
Ser Leu Phe Thr Asp Leu Leu Asn Phe Asp Asp Pro Leu Asn Ile Glu 
145                 150                 155                 160 
Ala Ala Glu His His Leu Arg Asp Lys Glu Asp Phe Arg Asn Lys Val 
                165                 170                 175     
Asp Asp Tyr Ile Lys Arg Tyr Ala Arg 
            180                 185 

<210> 12
<211> 170
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2G1 E2 domain

<400> 12
Met Thr Glu Leu Gln Ser Ala Leu Leu Leu Arg Arg Gln Leu Ala Glu 
1               5                   10                  15      
Leu Asn Lys Asn Pro Val Glu Gly Phe Ser Ala Gly Leu Ile Asp Asp 
            20                  25                  30          
Asn Asp Leu Tyr Arg Trp Glu Val Leu Ile Ile Gly Pro Pro Asp Thr 
        35                  40                  45              
Leu Tyr Glu Gly Gly Val Phe Lys Ala His Leu Thr Phe Pro Lys Asp 
    50                  55                  60                  
Tyr Pro Leu Arg Pro Pro Lys Met Lys Phe Ile Thr Glu Ile Trp His 
65                  70                  75                  80  
Pro Asn Val Asp Lys Asn Gly Asp Val Cys Ile Ser Ile Leu His Glu 
                85                  90                  95      
Pro Gly Glu Asp Lys Tyr Gly Tyr Glu Lys Pro Glu Glu Arg Trp Leu 
            100                 105                 110         
Pro Ile His Thr Val Glu Thr Ile Met Ile Ser Val Ile Ser Met Leu 
        115                 120                 125             
Ala Asp Pro Asn Gly Asp Ser Pro Ala Asn Val Asp Ala Ala Lys Glu 
    130                 135                 140                 
Trp Arg Glu Asp Arg Asn Gly Glu Phe Lys Arg Lys Val Ala Arg Cys 
145                 150                 155                 160 
Val Arg Lys Ser Gln Glu Thr Ala Phe Glu 
                165                 170 

<210> 13
<211> 165
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2G2 E2 domain

<400> 13
Met Ala Gly Thr Ala Leu Lys Arg Leu Met Ala Glu Tyr Lys Gln Leu 
1               5                   10                  15      
Thr Leu Asn Pro Pro Glu Gly Ile Val Ala Gly Pro Met Asn Glu Glu 
            20                  25                  30          
Asn Phe Phe Glu Trp Glu Ala Leu Ile Met Gly Pro Glu Asp Thr Cys 
        35                  40                  45              
Phe Glu Phe Gly Val Phe Pro Ala Ile Leu Ser Phe Pro Leu Asp Tyr 
    50                  55                  60                  
Pro Leu Ser Pro Pro Lys Met Arg Phe Thr Cys Glu Met Phe His Pro 
65                  70                  75                  80  
Asn Ile Tyr Pro Asp Gly Arg Val Cys Ile Ser Ile Leu His Ala Pro 
                85                  90                  95      
Gly Asp Asp Pro Met Gly Tyr Glu Ser Ser Ala Glu Arg Trp Ser Pro 
            100                 105                 110         
Val Gln Ser Val Glu Lys Ile Leu Leu Ser Val Val Ser Met Leu Ala 
        115                 120                 125             
Glu Pro Asn Asp Glu Ser Gly Ala Asn Val Asp Ala Ser Lys Met Trp 
    130                 135                 140                 
Arg Asp Asp Arg Glu Gln Phe Tyr Lys Ile Ala Lys Gln Ile Val Gln 
145                 150                 155                 160 
Lys Ser Leu Gly Leu 
                165 

<210> 14
<211> 183
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2H E2 domain

<400> 14
Met Ser Ser Pro Ser Pro Gly Lys Arg Arg Met Asp Thr Asp Val Val 
1               5                   10                  15      
Lys Leu Ile Glu Ser Lys His Glu Val Thr Ile Leu Gly Gly Leu Asn 
            20                  25                  30          
Glu Phe Val Val Lys Phe Tyr Gly Pro Gln Gly Thr Pro Tyr Glu Gly 
        35                  40                  45              
Gly Val Trp Lys Val Arg Val Asp Leu Pro Asp Lys Tyr Pro Phe Lys 
    50                  55                  60                  
Ser Pro Ser Ile Gly Phe Met Asn Lys Ile Phe His Pro Asn Ile Asp 
65                  70                  75                  80  
Glu Ala Ser Gly Thr Val Cys Leu Asp Val Ile Asn Gln Thr Trp Thr 
                85                  90                  95      
Ala Leu Tyr Asp Leu Thr Asn Ile Phe Glu Ser Phe Leu Pro Gln Leu 
            100                 105                 110         
Leu Ala Tyr Pro Asn Pro Ile Asp Pro Leu Asn Gly Asp Ala Ala Ala 
        115                 120                 125             
Met Tyr Leu His Arg Pro Glu Glu Tyr Lys Gln Lys Ile Lys Glu Tyr 
    130                 135                 140                 
Ile Gln Lys Tyr Ala Thr Glu Glu Ala Leu Lys Glu Gln Glu Glu Gly 
145                 150                 155                 160 
Thr Gly Asp Ser Ser Ser Glu Ser Ser Met Ser Asp Phe Ser Glu Asp 
                165                 170                 175     
Glu Ala Gln Asp Met Glu Leu 
            180             

<210> 15
<211> 158
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2I E2 domain

<400> 15
Met Ser Gly Ile Ala Leu Ser Arg Leu Ala Gln Glu Arg Lys Ala Trp 
1               5                   10                  15      
Arg Lys Asp His Pro Phe Gly Phe Val Ala Val Pro Thr Lys Asn Pro 
            20                  25                  30          
Asp Gly Thr Met Asn Leu Met Asn Trp Glu Cys Ala Ile Pro Gly Lys 
        35                  40                  45              
Lys Gly Thr Pro Trp Glu Gly Gly Leu Phe Lys Leu Arg Met Leu Phe 
    50                  55                  60                  
Lys Asp Asp Tyr Pro Ser Ser Pro Pro Lys Cys Lys Phe Glu Pro Pro 
65                  70                  75                  80  
Leu Phe His Pro Asn Val Tyr Pro Ser Gly Thr Val Cys Leu Ser Ile 
                85                  90                  95      
Leu Glu Glu Asp Lys Asp Trp Arg Pro Ala Ile Thr Ile Lys Gln Ile 
            100                 105                 110         
Leu Leu Gly Ile Gln Glu Leu Leu Asn Glu Pro Asn Ile Gln Asp Pro 
        115                 120                 125             
Ala Gln Ala Glu Ala Tyr Thr Ile Tyr Cys Gln Asn Arg Val Glu Tyr 
    130                 135                 140                 
Glu Lys Arg Val Arg Ala Gln Ala Lys Lys Phe Ala Pro Ser 
145                 150                 155             

<210> 16
<211> 318
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2J1 E2 domain

<400> 16
Met Glu Thr Arg Tyr Asn Leu Lys Ser Pro Ala Val Lys Arg Leu Met 
1               5                   10                  15      
Lys Glu Ala Ala Glu Leu Lys Asp Pro Thr Asp His Tyr His Ala Gln 
            20                  25                  30          
Pro Leu Glu Asp Asn Leu Phe Glu Trp His Phe Thr Val Arg Gly Pro 
        35                  40                  45              
Pro Asp Ser Asp Phe Asp Gly Gly Val Tyr His Gly Arg Ile Val Leu 
    50                  55                  60                  
Pro Pro Glu Tyr Pro Met Lys Pro Pro Ser Ile Ile Leu Leu Thr Ala 
65                  70                  75                  80  
Asn Gly Arg Phe Glu Val Gly Lys Lys Ile Cys Leu Ser Ile Ser Gly 
                85                  90                  95      
His His Pro Glu Thr Trp Gln Pro Ser Trp Ser Ile Arg Thr Ala Leu 
            100                 105                 110         
Leu Ala Ile Ile Gly Phe Met Pro Thr Lys Gly Glu Gly Ala Ile Gly 
        115                 120                 125             
Ser Leu Asp Tyr Thr Pro Glu Glu Arg Arg Ala Leu Ala Lys Lys Ser 
    130                 135                 140                 
Gln Asp Phe Cys Cys Glu Gly Cys Gly Ser Ala Met Lys Asp Val Leu 
145                 150                 155                 160 
Leu Pro Leu Lys Ser Gly Ser Asp Ser Ser Gln Ala Asp Gln Glu Ala 
                165                 170                 175     
Lys Glu Leu Ala Arg Gln Ile Ser Phe Lys Ala Glu Val Asn Ser Ser 
            180                 185                 190         
Gly Lys Thr Ile Ser Glu Ser Asp Leu Asn His Ser Phe Ser Leu Thr 
        195                 200                 205             
Asp Leu Gln Asp Asp Ile Pro Thr Thr Phe Gln Gly Ala Thr Ala Ser 
    210                 215                 220                 
Thr Ser Tyr Gly Leu Gln Asn Ser Ser Ala Ala Ser Phe His Gln Pro 
225                 230                 235                 240 
Thr Gln Pro Val Ala Lys Asn Thr Ser Met Ser Pro Arg Gln Arg Arg 
                245                 250                 255     
Ala Gln Gln Gln Ser Gln Arg Arg Leu Ser Thr Ser Pro Asp Val Ile 
            260                 265                 270         
Gln Gly His Gln Pro Arg Asp Asn His Thr Asp His Gly Gly Ser Ala 
        275                 280                 285             
Val Leu Ile Val Ile Leu Thr Leu Ala Leu Ala Ala Leu Ile Phe Arg 
    290                 295                 300                 
Arg Ile Tyr Leu Ala Asn Glu Tyr Ile Phe Asp Phe Glu Leu 
305                 310                 315             

<210> 17
<211> 259
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2J2 E2 domain

<400> 17
Met Ser Ser Thr Ser Ser Lys Arg Ala Pro Thr Thr Ala Thr Gln Arg 
1               5                   10                  15      
Leu Lys Gln Asp Tyr Leu Arg Ile Lys Lys Asp Pro Val Pro Tyr Ile 
            20                  25                  30          
Cys Ala Glu Pro Leu Pro Ser Asn Ile Leu Glu Trp His Tyr Val Val 
        35                  40                  45              
Arg Gly Pro Glu Met Thr Pro Tyr Glu Gly Gly Tyr Tyr His Gly Lys 
    50                  55                  60                  
Leu Ile Phe Pro Arg Glu Phe Pro Phe Lys Pro Pro Ser Ile Tyr Met 
65                  70                  75                  80  
Ile Thr Pro Asn Gly Arg Phe Lys Cys Asn Thr Arg Leu Cys Leu Ser 
                85                  90                  95      
Ile Thr Asp Phe His Pro Asp Thr Trp Asn Pro Ala Trp Ser Val Ser 
            100                 105                 110         
Thr Ile Leu Thr Gly Leu Leu Ser Phe Met Val Glu Lys Gly Pro Thr 
        115                 120                 125             
Leu Gly Ser Ile Glu Thr Ser Asp Phe Thr Lys Arg Gln Leu Ala Val 
    130                 135                 140                 
Gln Ser Leu Ala Phe Asn Leu Lys Asp Lys Val Phe Cys Glu Leu Phe 
145                 150                 155                 160 
Pro Glu Val Val Glu Glu Ile Lys Gln Lys Gln Lys Ala Gln Asp Glu 
                165                 170                 175     
Leu Ser Ser Arg Pro Gln Thr Leu Pro Leu Pro Asp Val Val Pro Asp 
            180                 185                 190         
Gly Glu Thr His Leu Val Gln Asn Gly Ile Gln Leu Leu Asn Gly His 
        195                 200                 205             
Ala Pro Gly Ala Val Pro Asn Leu Ala Gly Leu Gln Gln Ala Asn Arg 
    210                 215                 220                 
His His Gly Leu Leu Gly Gly Ala Leu Ala Asn Leu Phe Val Ile Val 
225                 230                 235                 240 
Gly Phe Ala Ala Phe Ala Tyr Thr Val Lys Tyr Val Leu Arg Ser Ile 
                245                 250                 255     
Ala Gln Glu 
            

<210> 18
<211> 200
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2K E2 domain

<400> 18
Met Ala Asn Ile Ala Val Gln Arg Ile Lys Arg Glu Phe Lys Glu Val 
1               5                   10                  15      
Leu Lys Ser Glu Glu Thr Ser Lys Asn Gln Ile Lys Val Asp Leu Val 
            20                  25                  30          
Asp Glu Asn Phe Thr Glu Leu Arg Gly Glu Ile Ala Gly Pro Pro Asp 
        35                  40                  45              
Thr Pro Tyr Glu Gly Gly Arg Tyr Gln Leu Glu Ile Lys Ile Pro Glu 
    50                  55                  60                  
Thr Tyr Pro Phe Asn Pro Pro Lys Val Arg Phe Ile Thr Lys Ile Trp 
65                  70                  75                  80  
His Pro Asn Ile Ser Ser Val Thr Gly Ala Ile Cys Leu Asp Ile Leu 
                85                  90                  95      
Lys Asp Gln Trp Ala Ala Ala Met Thr Leu Arg Thr Val Leu Leu Ser 
            100                 105                 110         
Leu Gln Ala Leu Leu Ala Ala Ala Glu Pro Asp Asp Pro Gln Asp Ala 
        115                 120                 125             
Val Val Ala Asn Gln Tyr Lys Gln Asn Pro Glu Met Phe Lys Gln Thr 
    130                 135                 140                 
Ala Arg Leu Trp Ala His Val Tyr Ala Gly Ala Pro Val Ser Ser Pro 
145                 150                 155                 160 
Glu Tyr Thr Lys Lys Ile Glu Asn Leu Cys Ala Met Gly Phe Asp Arg 
                165                 170                 175     
Asn Ala Val Ile Val Ala Leu Ser Ser Lys Ser Trp Asp Val Glu Thr 
            180                 185                 190         
Ala Thr Glu Leu Leu Leu Ser Asn 
        195                 200 

<210> 19
<211> 154
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2L3 E2 domain

<400> 19
Met Ala Ala Ser Arg Arg Leu Met Lys Glu Leu Glu Glu Ile Arg Lys 
1               5                   10                  15      
Cys Gly Met Lys Asn Phe Arg Asn Ile Gln Val Asp Glu Ala Asn Leu 
            20                  25                  30          
Leu Thr Trp Gln Gly Leu Ile Val Pro Asp Asn Pro Pro Tyr Asp Lys 
        35                  40                  45              
Gly Ala Phe Arg Ile Glu Ile Asn Phe Pro Ala Glu Tyr Pro Phe Lys 
    50                  55                  60                  
Pro Pro Lys Ile Thr Phe Lys Thr Lys Ile Tyr His Pro Asn Ile Asp 
65                  70                  75                  80  
Glu Lys Gly Gln Val Cys Leu Pro Val Ile Ser Ala Glu Asn Trp Lys 
                85                  90                  95      
Pro Ala Thr Lys Thr Asp Gln Val Ile Gln Ser Leu Ile Ala Leu Val 
            100                 105                 110         
Asn Asp Pro Gln Pro Glu His Pro Leu Arg Ala Asp Leu Ala Glu Glu 
        115                 120                 125             
Tyr Ser Lys Asp Arg Lys Lys Phe Cys Lys Asn Ala Glu Glu Phe Thr 
    130                 135                 140                 
Lys Lys Tyr Gly Glu Lys Arg Pro Val Asp 
145                 150                 

<210> 20
<211> 153
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2L6 E2 domain

<400> 20
Met Met Ala Ser Met Arg Val Val Lys Glu Leu Glu Asp Leu Gln Lys 
1               5                   10                  15      
Lys Pro Pro Pro Tyr Leu Arg Asn Leu Ser Ser Asp Asp Ala Asn Val 
            20                  25                  30          
Leu Val Trp His Ala Leu Leu Leu Pro Asp Gln Pro Pro Tyr His Leu 
        35                  40                  45              
Lys Ala Phe Asn Leu Arg Ile Ser Phe Pro Pro Glu Tyr Pro Phe Lys 
    50                  55                  60                  
Pro Pro Met Ile Lys Phe Thr Thr Lys Ile Tyr His Pro Asn Val Asp 
65                  70                  75                  80  
Glu Asn Gly Gln Ile Cys Leu Pro Ile Ile Ser Ser Glu Asn Trp Lys 
                85                  90                  95      
Pro Cys Thr Lys Thr Cys Gln Val Leu Glu Ala Leu Asn Val Leu Val 
            100                 105                 110         
Asn Arg Pro Asn Ile Arg Glu Pro Leu Arg Met Asp Leu Ala Asp Leu 
        115                 120                 125             
Leu Thr Gln Asn Pro Glu Leu Phe Arg Lys Asn Ala Glu Glu Phe Thr 
    130                 135                 140                 
Leu Arg Phe Gly Val Asp Arg Pro Ser 
145                 150             

<210> 21
<211> 183
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2M E2 domain

<400> 21
Met Ile Lys Leu Phe Ser Leu Lys Gln Gln Lys Lys Glu Glu Glu Ser 
1               5                   10                  15      
Ala Gly Gly Thr Lys Gly Ser Ser Lys Lys Ala Ser Ala Ala Gln Leu 
            20                  25                  30          
Arg Ile Gln Lys Asp Ile Asn Glu Leu Asn Leu Pro Lys Thr Cys Asp 
        35                  40                  45              
Ile Ser Phe Ser Asp Pro Asp Asp Leu Leu Asn Phe Lys Leu Val Ile 
    50                  55                  60                  
Cys Pro Asp Glu Gly Phe Tyr Lys Ser Gly Lys Phe Val Phe Ser Phe 
65                  70                  75                  80  
Lys Val Gly Gln Gly Tyr Pro His Asp Pro Pro Lys Val Lys Cys Glu 
                85                  90                  95      
Thr Met Val Tyr His Pro Asn Ile Asp Leu Glu Gly Asn Val Cys Leu 
            100                 105                 110         
Asn Ile Leu Arg Glu Asp Trp Lys Pro Val Leu Thr Ile Asn Ser Ile 
        115                 120                 125             
Ile Tyr Gly Leu Gln Tyr Leu Phe Leu Glu Pro Asn Pro Glu Asp Pro 
    130                 135                 140                 
Leu Asn Lys Glu Ala Ala Glu Val Leu Gln Asn Asn Arg Arg Leu Phe 
145                 150                 155                 160 
Glu Gln Asn Val Gln Arg Ser Met Arg Gly Gly Tyr Ile Gly Ser Thr 
                165                 170                 175     
Tyr Phe Glu Arg Cys Leu Lys 
            180             

<210> 22
<211> 152
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2N E2 domain

<400> 22
Met Ala Gly Leu Pro Arg Arg Ile Ile Lys Glu Thr Gln Arg Leu Leu 
1               5                   10                  15      
Ala Glu Pro Val Pro Gly Ile Lys Ala Glu Pro Asp Glu Ser Asn Ala 
            20                  25                  30          
Arg Tyr Phe His Val Val Ile Ala Gly Pro Gln Asp Ser Pro Phe Glu 
        35                  40                  45              
Gly Gly Thr Phe Lys Leu Glu Leu Phe Leu Pro Glu Glu Tyr Pro Met 
    50                  55                  60                  
Ala Ala Pro Lys Val Arg Phe Met Thr Lys Ile Tyr His Pro Asn Val 
65                  70                  75                  80  
Asp Lys Leu Gly Arg Ile Cys Leu Asp Ile Leu Lys Asp Lys Trp Ser 
                85                  90                  95      
Pro Ala Leu Gln Ile Arg Thr Val Leu Leu Ser Ile Gln Ala Leu Leu 
            100                 105                 110         
Ser Ala Pro Asn Pro Asp Asp Pro Leu Ala Asn Asp Val Ala Glu Gln 
        115                 120                 125             
Trp Lys Thr Asn Glu Ala Gln Ala Ile Glu Thr Ala Arg Ala Trp Thr 
    130                 135                 140                 
Arg Leu Tyr Ala Met Asn Asn Ile 
145                 150         

<210> 23
<211> 153
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2NL E2 domain

<400> 23
Met Ala Glu Leu Pro His Arg Ile Ile Lys Glu Thr Gln Arg Leu Leu 
1               5                   10                  15      
Ala Glu Pro Val Pro Gly Ile Lys Ala Glu Pro Asp Glu Ser Asn Ala 
            20                  25                  30          
Arg Tyr Phe His Val Val Ile Ala Gly Glu Ser Lys Asp Ser Pro Phe 
        35                  40                  45              
Glu Gly Gly Thr Phe Lys Arg Glu Leu Leu Leu Ala Glu Glu Tyr Pro 
    50                  55                  60                  
Met Ala Ala Pro Lys Val Arg Phe Met Thr Lys Ile Tyr His Pro Asn 
65                  70                  75                  80  
Val Asp Lys Leu Glu Arg Ile Ser Leu Asp Ile Leu Lys Asp Lys Trp 
                85                  90                  95      
Ser Pro Ala Leu Gln Ile Arg Thr Val Leu Leu Ser Ile Gln Ala Leu 
            100                 105                 110         
Leu Asn Ala Pro Asn Pro Asp Asp Pro Leu Ala Asn Asp Val Val Glu 
        115                 120                 125             
Gln Trp Lys Thr Asn Glu Ala Gln Ala Ile Glu Thr Ala Arg Ala Trp 
    130                 135                 140                 
Thr Arg Leu Tyr Ala Met Asn Ser Ile 
145                 150             

<210> 24
<211> 1292
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2O E2 domain

<400> 24
Met Ala Asp Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro Ala Gln 
1               5                   10                  15      
Ala Pro Ala Pro Ala Pro Glu Ala Val Pro Ala Pro Ala Ala Ala Pro 
            20                  25                  30          
Val Pro Ala Pro Ala Pro Ala Ser Asp Ser Ala Ser Gly Pro Ser Ser 
        35                  40                  45              
Asp Ser Gly Pro Glu Ala Gly Ser Gln Arg Leu Leu Phe Ser His Asp 
    50                  55                  60                  
Leu Val Ser Gly Arg Tyr Arg Gly Ser Val His Phe Gly Leu Val Arg 
65                  70                  75                  80  
Leu Ile His Gly Glu Asp Ser Asp Ser Glu Gly Glu Glu Glu Gly Arg 
                85                  90                  95      
Gly Ser Ser Gly Cys Ser Glu Ala Gly Gly Ala Gly His Glu Glu Gly 
            100                 105                 110         
Arg Ala Ser Pro Leu Arg Arg Gly Tyr Val Arg Val Gln Trp Tyr Pro 
        115                 120                 125             
Glu Gly Val Lys Gln His Val Lys Glu Thr Lys Leu Lys Leu Glu Asp 
    130                 135                 140                 
Arg Ser Val Val Pro Arg Asp Val Val Arg His Met Arg Ser Thr Asp 
145                 150                 155                 160 
Ser Gln Cys Gly Thr Val Ile Asp Val Asn Ile Asp Cys Ala Val Lys 
                165                 170                 175     
Leu Ile Gly Thr Asn Cys Ile Ile Tyr Pro Val Asn Ser Lys Asp Leu 
            180                 185                 190         
Gln His Ile Trp Pro Phe Met Tyr Gly Asp Tyr Ile Ala Tyr Asp Cys 
        195                 200                 205             
Trp Leu Gly Lys Val Tyr Asp Leu Lys Asn Gln Ile Ile Leu Lys Leu 
    210                 215                 220                 
Ser Asn Gly Ala Arg Cys Ser Met Asn Thr Glu Asp Gly Ala Lys Leu 
225                 230                 235                 240 
Tyr Asp Val Cys Pro His Val Ser Asp Ser Gly Leu Phe Phe Asp Asp 
                245                 250                 255     
Ser Tyr Gly Phe Tyr Pro Gly Gln Val Leu Ile Gly Pro Ala Lys Ile 
            260                 265                 270         
Phe Ser Ser Val Gln Trp Leu Ser Gly Val Lys Pro Val Leu Ser Thr 
        275                 280                 285             
Lys Ser Lys Phe Arg Val Val Val Glu Glu Val Gln Val Val Glu Leu 
    290                 295                 300                 
Lys Val Thr Trp Ile Thr Lys Ser Phe Cys Pro Gly Gly Thr Asp Ser 
305                 310                 315                 320 
Val Ser Pro Pro Pro Ser Val Ile Thr Gln Glu Asn Leu Gly Arg Val 
                325                 330                 335     
Lys Arg Leu Gly Cys Phe Asp His Ala Gln Arg Gln Leu Gly Glu Arg 
            340                 345                 350         
Cys Leu Tyr Val Phe Pro Ala Lys Val Glu Pro Ala Lys Ile Ala Trp 
        355                 360                 365             
Glu Cys Pro Glu Lys Asn Cys Ala Gln Gly Glu Gly Ser Met Ala Lys 
    370                 375                 380                 
Lys Val Lys Arg Leu Leu Lys Lys Gln Val Val Arg Ile Met Ser Cys 
385                 390                 395                 400 
Ser Pro Asp Thr Gln Cys Ser Arg Asp His Ser Met Glu Asp Pro Asp 
                405                 410                 415     
Lys Lys Gly Glu Ser Lys Thr Lys Ser Glu Ala Glu Ser Ala Ser Pro 
            420                 425                 430         
Glu Glu Thr Pro Asp Gly Ser Ala Ser Pro Val Glu Met Gln Asp Glu 
        435                 440                 445             
Gly Ala Glu Glu Pro His Glu Ala Gly Glu Gln Leu Pro Pro Phe Leu 
    450                 455                 460                 
Leu Lys Glu Gly Arg Asp Asp Arg Leu His Ser Ala Glu Gln Asp Ala 
465                 470                 475                 480 
Asp Asp Glu Ala Ala Asp Asp Thr Asp Asp Thr Ser Ser Val Thr Ser 
                485                 490                 495     
Ser Ala Ser Ser Thr Thr Ser Ser Gln Ser Gly Ser Gly Thr Ser Arg 
            500                 505                 510         
Lys Lys Ser Ile Pro Leu Ser Ile Lys Asn Leu Lys Arg Lys His Lys 
        515                 520                 525             
Arg Lys Lys Asn Lys Ile Thr Arg Asp Phe Lys Pro Gly Asp Arg Val 
    530                 535                 540                 
Ala Val Glu Val Val Thr Thr Met Thr Ser Ala Asp Val Met Trp Gln 
545                 550                 555                 560 
Asp Gly Ser Val Glu Cys Asn Ile Arg Ser Asn Asp Leu Phe Pro Val 
                565                 570                 575     
His His Leu Asp Asn Asn Glu Phe Cys Pro Gly Asp Phe Val Val Asp 
            580                 585                 590         
Lys Arg Val Gln Ser Cys Pro Asp Pro Ala Val Tyr Gly Val Val Gln 
        595                 600                 605             
Ser Gly Asp His Ile Gly Arg Thr Cys Met Val Lys Trp Phe Lys Leu 
    610                 615                 620                 
Arg Pro Ser Gly Asp Asp Val Glu Leu Ile Gly Glu Glu Glu Asp Val 
625                 630                 635                 640 
Ser Val Tyr Asp Ile Ala Asp His Pro Asp Phe Arg Phe Arg Thr Thr 
                645                 650                 655     
Asp Ile Val Ile Arg Ile Gly Asn Thr Glu Asp Gly Ala Pro His Lys 
            660                 665                 670         
Glu Asp Glu Pro Ser Val Gly Gln Val Ala Arg Val Asp Val Ser Ser 
        675                 680                 685             
Lys Val Glu Val Val Trp Ala Asp Asn Ser Lys Thr Ile Ile Leu Pro 
    690                 695                 700                 
Gln His Leu Tyr Asn Ile Glu Ser Glu Ile Glu Glu Ser Asp Tyr Asp 
705                 710                 715                 720 
Ser Val Glu Gly Ser Thr Ser Gly Ala Ser Ser Asp Glu Trp Glu Asp 
                725                 730                 735     
Asp Ser Asp Ser Trp Glu Thr Asp Asn Gly Leu Val Glu Asp Glu His 
            740                 745                 750         
Pro Lys Ile Glu Glu Pro Pro Ile Pro Pro Leu Glu Gln Pro Val Ala 
        755                 760                 765             
Pro Glu Asp Lys Gly Val Val Ile Ser Glu Glu Ala Ala Thr Ala Ala 
    770                 775                 780                 
Val Gln Gly Ala Val Ala Met Ala Ala Pro Met Ala Gly Leu Met Glu 
785                 790                 795                 800 
Lys Ala Gly Lys Asp Gly Pro Pro Lys Ser Phe Arg Glu Leu Lys Glu 
                805                 810                 815     
Ala Ile Lys Ile Leu Glu Ser Leu Lys Asn Met Thr Val Glu Gln Leu 
            820                 825                 830         
Leu Thr Gly Ser Pro Thr Ser Pro Thr Val Glu Pro Glu Lys Pro Thr 
        835                 840                 845             
Arg Glu Lys Lys Phe Leu Asp Asp Ile Lys Lys Leu Gln Glu Asn Leu 
    850                 855                 860                 
Lys Lys Thr Leu Asp Asn Val Ala Ile Val Glu Glu Glu Lys Met Glu 
865                 870                 875                 880 
Ala Val Pro Asp Val Glu Arg Lys Glu Asp Lys Pro Glu Gly Gln Ser 
                885                 890                 895     
Pro Val Lys Ala Glu Trp Pro Ser Glu Thr Pro Val Leu Cys Gln Gln 
            900                 905                 910         
Cys Gly Gly Lys Pro Gly Val Thr Phe Thr Ser Ala Lys Gly Glu Val 
        915                 920                 925             
Phe Ser Val Leu Glu Phe Ala Pro Ser Asn His Ser Phe Lys Lys Ile 
    930                 935                 940                 
Glu Phe Gln Pro Pro Glu Ala Lys Lys Phe Phe Ser Thr Val Arg Lys 
945                 950                 955                 960 
Glu Met Ala Leu Leu Ala Thr Ser Leu Pro Glu Gly Ile Met Val Lys 
                965                 970                 975     
Thr Phe Glu Asp Arg Met Asp Leu Phe Ser Ala Leu Ile Lys Gly Pro 
            980                 985                 990         
Thr Arg Thr Pro Tyr Glu Asp Gly Leu Tyr Leu Phe Asp Ile Gln Leu 
        995                 1000                1005            
Pro Asn Ile Tyr Pro Ala Val Pro Pro His Phe Cys Tyr Leu Ser Gln 
    1010                1015                1020                
Cys Ser Gly Arg Leu Asn Pro Asn Leu Tyr Asp Asn Gly Lys Val Cys 
1025                1030                1035                1040
Val Ser Leu Leu Gly Thr Trp Ile Gly Lys Gly Thr Glu Arg Trp Thr 
                1045                1050                1055    
Ser Lys Ser Ser Leu Leu Gln Val Leu Ile Ser Ile Gln Gly Leu Ile 
            1060                1065                1070        
Leu Val Asn Glu Pro Tyr Tyr Asn Glu Ala Gly Phe Asp Ser Asp Arg 
        1075                1080                1085            
Gly Leu Gln Glu Gly Tyr Glu Asn Ser Arg Cys Tyr Asn Glu Met Ala 
    1090                1095                1100                
Leu Ile Arg Val Val Gln Ser Met Thr Gln Leu Val Arg Arg Pro Pro 
1105                1110                1115                1120
Glu Val Phe Glu Gln Glu Ile Arg Gln His Phe Ser Thr Gly Gly Trp 
                1125                1130                1135    
Arg Leu Val Asn Arg Ile Glu Ser Trp Leu Glu Thr His Ala Leu Leu 
            1140                1145                1150        
Glu Lys Ala Gln Ala Leu Pro Asn Gly Val Pro Lys Ala Ser Ser Ser 
        1155                1160                1165            
Pro Glu Pro Pro Ala Val Ala Glu Leu Ser Asp Ser Gly Gln Gln Glu 
    1170                1175                1180                
Pro Glu Asp Gly Gly Pro Ala Pro Gly Glu Ala Ser Gln Gly Ser Asp 
1185                1190                1195                1200
Ser Glu Gly Gly Ala Gln Gly Leu Ala Ser Ala Ser Arg Asp His Thr 
                1205                1210                1215    
Asp Gln Thr Ser Glu Thr Ala Pro Asp Ala Ser Val Pro Pro Ser Val 
            1220                1225                1230        
Lys Pro Lys Lys Arg Arg Lys Ser Tyr Arg Ser Phe Leu Pro Glu Lys 
        1235                1240                1245            
Ser Gly Tyr Pro Asp Ile Gly Phe Pro Leu Phe Pro Leu Ser Lys Gly 
    1250                1255                1260                
Phe Ile Lys Ser Ile Arg Gly Val Leu Thr Gln Phe Arg Ala Ala Leu 
1265                1270                1275                1280
Leu Glu Ala Gly Met Pro Glu Cys Thr Glu Asp Lys 
                1285                1290        

<210> 25
<211> 422
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2Q1 E2 domain

<400> 25
Met Gln Gln Pro Gln Pro Gln Gly Gln Gln Gln Pro Gly Pro Gly Gln 
1               5                   10                  15      
Gln Leu Gly Gly Gln Gly Ala Ala Pro Gly Ala Gly Gly Gly Pro Gly 
            20                  25                  30          
Gly Gly Pro Gly Pro Gly Pro Cys Leu Arg Arg Glu Leu Lys Leu Leu 
        35                  40                  45              
Glu Ser Ile Phe His Arg Gly His Glu Arg Phe Arg Ile Ala Ser Ala 
    50                  55                  60                  
Cys Leu Asp Glu Leu Ser Cys Glu Phe Leu Leu Ala Gly Ala Gly Gly 
65                  70                  75                  80  
Ala Gly Ala Gly Ala Ala Pro Gly Pro His Leu Pro Pro Arg Gly Ser 
                85                  90                  95      
Val Pro Gly Asp Pro Val Arg Ile His Cys Asn Ile Thr Glu Ser Tyr 
            100                 105                 110         
Pro Ala Val Pro Pro Ile Trp Ser Val Glu Ser Asp Asp Pro Asn Leu 
        115                 120                 125             
Ala Ala Val Leu Glu Arg Leu Val Asp Ile Lys Lys Gly Asn Thr Leu 
    130                 135                 140                 
Leu Leu Gln His Leu Lys Arg Ile Ile Ser Asp Leu Cys Lys Leu Tyr 
145                 150                 155                 160 
Asn Leu Pro Gln His Pro Asp Val Glu Met Leu Asp Gln Pro Leu Pro 
                165                 170                 175     
Ala Glu Gln Cys Thr Gln Glu Asp Val Ser Ser Glu Asp Glu Asp Glu 
            180                 185                 190         
Glu Met Pro Glu Asp Thr Glu Asp Leu Asp His Tyr Glu Met Lys Glu 
        195                 200                 205             
Glu Glu Pro Ala Glu Gly Lys Lys Ser Glu Asp Asp Gly Ile Gly Lys 
    210                 215                 220                 
Glu Asn Leu Ala Ile Leu Glu Lys Ile Lys Lys Asn Gln Arg Gln Asp 
225                 230                 235                 240 
Tyr Leu Asn Gly Ala Val Ser Gly Ser Val Gln Ala Thr Asp Arg Leu 
                245                 250                 255     
Met Lys Glu Leu Arg Asp Ile Tyr Arg Ser Gln Ser Phe Lys Gly Gly 
            260                 265                 270         
Asn Tyr Ala Val Glu Leu Val Asn Asp Ser Leu Tyr Asp Trp Asn Val 
        275                 280                 285             
Lys Leu Leu Lys Val Asp Gln Asp Ser Ala Leu His Asn Asp Leu Gln 
    290                 295                 300                 
Ile Leu Lys Glu Lys Glu Gly Ala Asp Phe Ile Leu Leu Asn Phe Ser 
305                 310                 315                 320 
Phe Lys Asp Asn Phe Pro Phe Asp Pro Pro Phe Val Arg Val Val Ser 
                325                 330                 335     
Pro Val Leu Ser Gly Gly Tyr Val Leu Gly Gly Gly Ala Ile Cys Met 
            340                 345                 350         
Glu Leu Leu Thr Lys Gln Gly Trp Ser Ser Ala Tyr Ser Ile Glu Ser 
        355                 360                 365             
Val Ile Met Gln Ile Ser Ala Thr Leu Val Lys Gly Lys Ala Arg Val 
    370                 375                 380                 
Gln Phe Gly Ala Asn Lys Ser Gln Tyr Ser Leu Thr Arg Ala Gln Gln 
385                 390                 395                 400 
Ser Tyr Lys Ser Leu Val Gln Ile His Glu Lys Asn Gly Trp Tyr Thr 
                405                 410                 415     
Pro Pro Lys Glu Asp Gly 
            420         

<210> 26
<211> 375
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2Q2 E2 domain

<400> 26
Met Ser Val Ser Gly Leu Lys Ala Glu Leu Lys Phe Leu Ala Ser Ile 
1               5                   10                  15      
Phe Asp Lys Asn His Glu Arg Phe Arg Ile Val Ser Trp Lys Leu Asp 
            20                  25                  30          
Glu Leu His Cys Gln Phe Leu Val Pro Gln Gln Gly Ser Pro His Ser 
        35                  40                  45              
Leu Pro Pro Pro Leu Thr Leu His Cys Asn Ile Thr Glu Ser Tyr Pro 
    50                  55                  60                  
Ser Ser Ser Pro Ile Trp Phe Val Asp Ser Glu Asp Pro Asn Leu Thr 
65                  70                  75                  80  
Ser Val Leu Glu Arg Leu Glu Asp Thr Lys Asn Asn Asn Leu Leu Arg 
                85                  90                  95      
Gln Gln Leu Lys Trp Leu Ile Cys Glu Leu Cys Ser Leu Tyr Asn Leu 
            100                 105                 110         
Pro Lys His Leu Asp Val Glu Met Leu Asp Gln Pro Leu Pro Thr Gly 
        115                 120                 125             
Gln Asn Gly Thr Thr Glu Glu Val Thr Ser Glu Glu Glu Glu Glu Glu 
    130                 135                 140                 
Glu Glu Met Ala Glu Asp Ile Glu Asp Leu Asp His Tyr Glu Met Lys 
145                 150                 155                 160 
Glu Glu Glu Pro Ile Ser Gly Lys Lys Ser Glu Asp Glu Gly Ile Glu 
                165                 170                 175     
Lys Glu Asn Leu Ala Ile Leu Glu Lys Ile Arg Lys Thr Gln Arg Gln 
            180                 185                 190         
Asp His Leu Asn Gly Ala Val Ser Gly Ser Val Gln Ala Ser Asp Arg 
        195                 200                 205             
Leu Met Lys Glu Leu Arg Asp Ile Tyr Arg Ser Gln Ser Tyr Lys Thr 
    210                 215                 220                 
Gly Ile Tyr Ser Val Glu Leu Ile Asn Asp Ser Leu Tyr Asp Trp His 
225                 230                 235                 240 
Val Lys Leu Gln Lys Val Asp Pro Asp Ser Pro Leu His Ser Asp Leu 
                245                 250                 255     
Gln Ile Leu Lys Glu Lys Glu Gly Ile Glu Tyr Ile Leu Leu Asn Phe 
            260                 265                 270         
Ser Phe Lys Asp Asn Phe Pro Phe Asp Pro Pro Phe Val Arg Val Val 
        275                 280                 285             
Leu Pro Val Leu Ser Gly Gly Tyr Val Leu Gly Gly Gly Ala Leu Cys 
    290                 295                 300                 
Met Glu Leu Leu Thr Lys Gln Gly Trp Ser Ser Ala Tyr Ser Ile Glu 
305                 310                 315                 320 
Ser Val Ile Met Gln Ile Asn Ala Thr Leu Val Lys Gly Lys Ala Arg 
                325                 330                 335     
Val Gln Phe Gly Ala Asn Lys Asn Gln Tyr Asn Leu Ala Arg Ala Gln 
            340                 345                 350         
Gln Ser Tyr Asn Ser Ile Val Gln Ile His Glu Lys Asn Gly Trp Tyr 
        355                 360                 365             
Thr Pro Pro Lys Glu Asp Gly 
    370                 375 

<210> 27
<211> 161
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2QL E2 domain

<400> 27
Met Lys Glu Leu Gln Asp Ile Ala Arg Leu Ser Asp Arg Phe Ile Ser 
1               5                   10                  15      
Val Glu Leu Val Asp Glu Ser Leu Phe Asp Trp Asn Val Lys Leu His 
            20                  25                  30          
Gln Val Asp Lys Asp Ser Val Leu Trp Gln Asp Met Lys Glu Thr Asn 
        35                  40                  45              
Thr Glu Phe Ile Leu Leu Asn Leu Thr Phe Pro Asp Asn Phe Pro Phe 
    50                  55                  60                  
Ser Pro Pro Phe Met Arg Val Leu Ser Pro Arg Leu Glu Asn Gly Tyr 
65                  70                  75                  80  
Val Leu Asp Gly Gly Ala Ile Cys Met Glu Leu Leu Thr Pro Arg Gly 
                85                  90                  95      
Trp Ser Ser Ala Tyr Thr Val Glu Ala Val Met Arg Gln Phe Ala Ala 
            100                 105                 110         
Ser Leu Val Lys Gly Gln Gly Arg Ile Cys Arg Lys Ala Gly Lys Ser 
        115                 120                 125             
Lys Lys Ser Phe Ser Arg Lys Glu Ala Glu Ala Thr Phe Lys Ser Leu 
    130                 135                 140                 
Val Lys Thr His Glu Lys Tyr Gly Trp Val Thr Pro Pro Val Ser Asp 
145                 150                 155                 160 
Gly 
    

<210> 28
<211> 236
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2R1 E2 domain

<400> 28
Met Ala Arg Pro Leu Val Pro Ser Ser Gln Lys Ala Leu Leu Leu Glu 
1               5                   10                  15      
Leu Lys Gly Leu Gln Glu Glu Pro Val Glu Gly Phe Arg Val Thr Leu 
            20                  25                  30          
Val Asp Glu Gly Asp Leu Tyr Asn Trp Glu Val Ala Ile Phe Gly Pro 
        35                  40                  45              
Pro Asn Thr Tyr Tyr Glu Gly Gly Tyr Phe Lys Ala Arg Leu Lys Phe 
    50                  55                  60                  
Pro Ile Asp Tyr Pro Tyr Ser Pro Pro Ala Phe Arg Phe Leu Thr Lys 
65                  70                  75                  80  
Met Trp His Pro Asn Ile Tyr Glu Thr Gly Asp Val Cys Ile Ser Ile 
                85                  90                  95      
Leu His Pro Pro Val Asp Asp Pro Gln Ser Gly Glu Leu Pro Ser Glu 
            100                 105                 110         
Arg Trp Asn Pro Thr Gln Asn Val Arg Thr Ile Leu Leu Ser Val Ile 
        115                 120                 125             
Ser Leu Leu Asn Glu Pro Asn Thr Phe Ser Pro Ala Asn Val Asp Ala 
    130                 135                 140                 
Ser Val Met Tyr Arg Lys Trp Lys Glu Ser Lys Gly Lys Asp Arg Glu 
145                 150                 155                 160 
Tyr Thr Asp Ile Ile Arg Lys Gln Val Leu Gly Thr Lys Val Asp Ala 
                165                 170                 175     
Glu Arg Asp Gly Val Lys Val Pro Thr Thr Leu Ala Glu Tyr Cys Val 
            180                 185                 190         
Lys Thr Lys Ala Pro Ala Pro Asp Glu Gly Ser Asp Leu Phe Tyr Asp 
        195                 200                 205             
Asp Tyr Tyr Glu Asp Gly Glu Val Glu Glu Glu Ala Asp Ser Cys Phe 
    210                 215                 220                 
Gly Asp Asp Glu Asp Asp Ser Gly Thr Glu Glu Ser 
225                 230                 235     

<210> 29
<211> 238
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2R2 E2 domain

<400> 29
Met Ala Gln Gln Gln Met Thr Ser Ser Gln Lys Ala Leu Met Leu Glu 
1               5                   10                  15      
Leu Lys Ser Leu Gln Glu Glu Pro Val Glu Gly Phe Arg Ile Thr Leu 
            20                  25                  30          
Val Asp Glu Ser Asp Leu Tyr Asn Trp Glu Val Ala Ile Phe Gly Pro 
        35                  40                  45              
Pro Asn Thr Leu Tyr Glu Gly Gly Tyr Phe Lys Ala His Ile Lys Phe 
    50                  55                  60                  
Pro Ile Asp Tyr Pro Tyr Ser Pro Pro Thr Phe Arg Phe Leu Thr Lys 
65                  70                  75                  80  
Met Trp His Pro Asn Ile Tyr Glu Asn Gly Asp Val Cys Ile Ser Ile 
                85                  90                  95      
Leu His Pro Pro Val Asp Asp Pro Gln Ser Gly Glu Leu Pro Ser Glu 
            100                 105                 110         
Arg Trp Asn Pro Thr Gln Asn Val Arg Thr Ile Leu Leu Ser Val Ile 
        115                 120                 125             
Ser Leu Leu Asn Glu Pro Asn Thr Phe Ser Pro Ala Asn Val Asp Ala 
    130                 135                 140                 
Ser Val Met Phe Arg Lys Trp Arg Asp Ser Lys Gly Lys Asp Lys Glu 
145                 150                 155                 160 
Tyr Ala Glu Ile Ile Arg Lys Gln Val Ser Ala Thr Lys Ala Glu Ala 
                165                 170                 175     
Glu Lys Asp Gly Val Lys Val Pro Thr Thr Leu Ala Glu Tyr Cys Ile 
            180                 185                 190         
Lys Thr Lys Val Pro Ser Asn Asp Asn Ser Ser Asp Leu Leu Tyr Asp 
        195                 200                 205             
Asp Leu Tyr Asp Asp Asp Ile Asp Asp Glu Asp Glu Glu Glu Glu Asp 
    210                 215                 220                 
Ala Asp Cys Tyr Asp Asp Asp Asp Ser Gly Asn Glu Glu Ser 
225                 230                 235             

<210> 30
<211> 222
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2S E2 domain

<400> 30
Met Asn Ser Asn Val Glu Asn Leu Pro Pro His Ile Ile Arg Leu Val 
1               5                   10                  15      
Tyr Lys Glu Val Thr Thr Leu Thr Ala Asp Pro Pro Asp Gly Ile Lys 
            20                  25                  30          
Val Phe Pro Asn Glu Glu Asp Leu Thr Asp Leu Gln Val Thr Ile Glu 
        35                  40                  45              
Gly Pro Glu Gly Thr Pro Tyr Ala Gly Gly Leu Phe Arg Met Lys Leu 
    50                  55                  60                  
Leu Leu Gly Lys Asp Phe Pro Ala Ser Pro Pro Lys Gly Tyr Phe Leu 
65                  70                  75                  80  
Thr Lys Ile Phe His Pro Asn Val Gly Ala Asn Gly Glu Ile Cys Val 
                85                  90                  95      
Asn Val Leu Lys Arg Asp Trp Thr Ala Glu Leu Gly Ile Arg His Val 
            100                 105                 110         
Leu Leu Thr Ile Lys Cys Leu Leu Ile His Pro Asn Pro Glu Ser Ala 
        115                 120                 125             
Leu Asn Glu Glu Ala Gly Arg Leu Leu Leu Glu Asn Tyr Glu Glu Tyr 
    130                 135                 140                 
Ala Ala Arg Ala Arg Leu Leu Thr Glu Ile His Gly Gly Ala Gly Gly 
145                 150                 155                 160 
Pro Ser Gly Arg Ala Glu Ala Gly Arg Ala Leu Ala Ser Gly Thr Glu 
                165                 170                 175     
Ala Ser Ser Thr Asp Pro Gly Ala Pro Gly Gly Pro Gly Gly Ala Glu 
            180                 185                 190         
Gly Pro Met Ala Lys Lys His Ala Gly Glu Arg Asp Lys Lys Leu Ala 
        195                 200                 205             
Ala Lys Lys Lys Thr Asp Lys Lys Arg Ala Leu Arg Arg Leu 
    210                 215                 220         

<210> 31
<211> 197
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2T E2 domain

<400> 31
Met Gln Arg Ala Ser Arg Leu Lys Arg Glu Leu His Met Leu Ala Thr 
1               5                   10                  15      
Glu Pro Pro Pro Gly Ile Thr Cys Trp Gln Asp Lys Asp Gln Met Asp 
            20                  25                  30          
Asp Leu Arg Ala Gln Ile Leu Gly Gly Ala Asn Thr Pro Tyr Glu Lys 
        35                  40                  45              
Gly Val Phe Lys Leu Glu Val Ile Ile Pro Glu Arg Tyr Pro Phe Glu 
    50                  55                  60                  
Pro Pro Gln Ile Arg Phe Leu Thr Pro Ile Tyr His Pro Asn Ile Asp 
65                  70                  75                  80  
Ser Ala Gly Arg Ile Cys Leu Asp Val Leu Lys Leu Pro Pro Lys Gly 
                85                  90                  95      
Ala Trp Arg Pro Ser Leu Asn Ile Ala Thr Val Leu Thr Ser Ile Gln 
            100                 105                 110         
Leu Leu Met Ser Glu Pro Asn Pro Asp Asp Pro Leu Met Ala Asp Ile 
        115                 120                 125             
Ser Ser Glu Phe Lys Tyr Asn Lys Pro Ala Phe Leu Lys Asn Ala Arg 
    130                 135                 140                 
Gln Trp Thr Glu Lys His Ala Arg Gln Lys Gln Lys Ala Asp Glu Glu 
145                 150                 155                 160 
Glu Met Leu Asp Asn Leu Pro Glu Ala Gly Asp Ser Arg Val His Asn 
                165                 170                 175     
Ser Thr Gln Lys Arg Lys Ala Ser Gln Leu Val Gly Ile Glu Lys Lys 
            180                 185                 190         
Phe His Pro Asp Val 
        195         

<210> 32
<211> 321
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2U E2 domain

<400> 32
Met His Gly Arg Ala Tyr Leu Leu Leu His Arg Asp Phe Cys Asp Leu 
1               5                   10                  15      
Lys Glu Asn Asn Tyr Lys Gly Ile Thr Ala Lys Pro Val Ser Glu Asp 
            20                  25                  30          
Met Met Glu Trp Glu Val Glu Ile Glu Gly Leu Gln Asn Ser Val Trp 
        35                  40                  45              
Gln Gly Leu Val Phe Gln Leu Thr Ile His Phe Thr Ser Glu Tyr Asn 
    50                  55                  60                  
Tyr Ala Pro Pro Val Val Lys Phe Ile Thr Ile Pro Phe His Pro Asn 
65                  70                  75                  80  
Val Asp Pro His Thr Gly Gln Pro Cys Ile Asp Phe Leu Asp Asn Pro 
                85                  90                  95      
Glu Lys Trp Asn Thr Asn Tyr Thr Leu Ser Ser Ile Leu Leu Ala Leu 
            100                 105                 110         
Gln Val Met Leu Ser Asn Pro Val Leu Glu Asn Pro Val Asn Leu Glu 
        115                 120                 125             
Ala Ala Arg Ile Leu Val Lys Asp Glu Ser Leu Tyr Arg Thr Ile Leu 
    130                 135                 140                 
Arg Leu Phe Asn Arg Pro Leu Gln Met Lys Asp Asp Ser Gln Glu Leu 
145                 150                 155                 160 
Pro Lys Asp Pro Arg Lys Cys Ile Arg Pro Ile Lys Thr Thr Ser Phe 
                165                 170                 175     
Ser Asp Tyr Tyr Gln Thr Trp Ser Arg Ile Ala Thr Ser Lys Ala Thr 
            180                 185                 190         
Glu Tyr Tyr Arg Thr Pro Leu Leu Lys Val Pro Asn Phe Ile Gly Gln 
        195                 200                 205             
Tyr Tyr Lys Trp Lys Lys Met Asp Leu Gln His Gln Lys Glu Trp Asn 
    210                 215                 220                 
Leu Lys Tyr Ser Val Ile Lys Cys Trp Leu Ala Arg Lys Arg Met Pro 
225                 230                 235                 240 
His Glu Val Thr His Ser Met Glu Glu Ile Lys Leu Cys Pro Thr Leu 
                245                 250                 255     
Ile Pro Thr Thr Asp Glu Ile Phe Leu Glu Ser Pro Thr Ala Ile Asn 
            260                 265                 270         
Ser Ile Thr Asp Ile Tyr Glu Thr Glu Glu Glu Gly Trp Lys Ser Asp 
        275                 280                 285             
Thr Ser Leu Tyr Glu Asn Asp Thr Asp Glu Pro Arg Glu Glu Glu Val 
    290                 295                 300                 
Glu Asp Leu Ile Ser Trp Thr Asn Thr Leu Asn Thr Asn Thr Ser Glu 
305                 310                 315                 320 
Asp 
    

<210> 33
<211> 147
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2V1 E2 domain

<400> 33
Met Ala Ala Thr Thr Gly Ser Gly Val Lys Val Pro Arg Asn Phe Arg 
1               5                   10                  15      
Leu Leu Glu Glu Leu Glu Glu Gly Gln Lys Gly Val Gly Asp Gly Thr 
            20                  25                  30          
Val Ser Trp Gly Leu Glu Asp Asp Glu Asp Met Thr Leu Thr Arg Trp 
        35                  40                  45              
Thr Gly Met Ile Ile Gly Pro Pro Arg Thr Ile Tyr Glu Asn Arg Ile 
    50                  55                  60                  
Tyr Ser Leu Lys Ile Glu Cys Gly Pro Lys Tyr Pro Glu Ala Pro Pro 
65                  70                  75                  80  
Phe Val Arg Phe Val Thr Lys Ile Asn Met Asn Gly Val Asn Ser Ser 
                85                  90                  95      
Asn Gly Val Val Asp Pro Arg Ala Ile Ser Val Leu Ala Lys Trp Gln 
            100                 105                 110         
Asn Ser Tyr Ser Ile Lys Val Val Leu Gln Glu Leu Arg Arg Leu Met 
        115                 120                 125             
Met Ser Lys Glu Asn Met Lys Leu Pro Gln Pro Pro Glu Gly Gln Cys 
    130                 135                 140                 
Tyr Ser Asn 
145         

<210> 34
<211> 145
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2V2 E2 domain

<400> 34
Met Ala Val Ser Thr Gly Val Lys Val Pro Arg Asn Phe Arg Leu Leu 
1               5                   10                  15      
Glu Glu Leu Glu Glu Gly Gln Lys Gly Val Gly Asp Gly Thr Val Ser 
            20                  25                  30          
Trp Gly Leu Glu Asp Asp Glu Asp Met Thr Leu Thr Arg Trp Thr Gly 
        35                  40                  45              
Met Ile Ile Gly Pro Pro Arg Thr Asn Tyr Glu Asn Arg Ile Tyr Ser 
    50                  55                  60                  
Leu Lys Val Glu Cys Gly Pro Lys Tyr Pro Glu Ala Pro Pro Ser Val 
65                  70                  75                  80  
Arg Phe Val Thr Lys Ile Asn Met Asn Gly Ile Asn Asn Ser Ser Gly 
                85                  90                  95      
Met Val Asp Ala Arg Ser Ile Pro Val Leu Ala Lys Trp Gln Asn Ser 
            100                 105                 110         
Tyr Ser Ile Lys Val Val Leu Gln Glu Leu Arg Arg Leu Met Met Ser 
        115                 120                 125             
Lys Glu Asn Met Lys Leu Pro Gln Pro Pro Glu Gly Gln Thr Tyr Asn 
    130                 135                 140                 
Asn 
145 

<210> 35
<211> 151
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2W E2 domain

<400> 35
Met Ala Ser Met Gln Lys Arg Leu Gln Lys Glu Leu Leu Ala Leu Gln 
1               5                   10                  15      
Asn Asp Pro Pro Pro Gly Met Thr Leu Asn Glu Lys Ser Val Gln Asn 
            20                  25                  30          
Ser Ile Thr Gln Trp Ile Val Asp Met Glu Gly Ala Pro Gly Thr Leu 
        35                  40                  45              
Tyr Glu Gly Glu Lys Phe Gln Leu Leu Phe Lys Phe Ser Ser Arg Tyr 
    50                  55                  60                  
Pro Phe Asp Ser Pro Gln Val Met Phe Thr Gly Glu Asn Ile Pro Val 
65                  70                  75                  80  
His Pro His Val Tyr Ser Asn Gly His Ile Cys Leu Ser Ile Leu Thr 
                85                  90                  95      
Glu Asp Trp Ser Pro Ala Leu Ser Val Gln Ser Val Cys Leu Ser Ile 
            100                 105                 110         
Ile Ser Met Leu Ser Ser Cys Lys Glu Lys Arg Arg Pro Pro Asp Asn 
        115                 120                 125             
Ser Phe Tyr Val Arg Thr Cys Asn Lys Asn Pro Lys Lys Thr Lys Trp 
    130                 135                 140                 
Trp Tyr His Asp Asp Thr Cys 
145                 150     

<210> 36
<211> 354
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2Z E2 domain

<400> 36
Met Ala Glu Ser Pro Thr Glu Glu Ala Ala Thr Ala Gly Ala Gly Ala 
1               5                   10                  15      
Ala Gly Pro Gly Ala Ser Ser Val Ala Gly Val Val Gly Val Ser Gly 
            20                  25                  30          
Ser Gly Gly Gly Phe Gly Pro Pro Phe Leu Pro Asp Val Trp Ala Ala 
        35                  40                  45              
Ala Ala Ala Ala Gly Gly Ala Gly Gly Pro Gly Ser Gly Leu Ala Pro 
    50                  55                  60                  
Leu Pro Gly Leu Pro Pro Ser Ala Ala Ala His Gly Ala Ala Leu Leu 
65                  70                  75                  80  
Ser His Trp Asp Pro Thr Leu Ser Ser Asp Trp Asp Gly Glu Arg Thr 
                85                  90                  95      
Ala Pro Gln Cys Leu Leu Arg Ile Lys Arg Asp Ile Met Ser Ile Tyr 
            100                 105                 110         
Lys Glu Pro Pro Pro Gly Met Phe Val Val Pro Asp Thr Val Asp Met 
        115                 120                 125             
Thr Lys Ile His Ala Leu Ile Thr Gly Pro Phe Asp Thr Pro Tyr Glu 
    130                 135                 140                 
Gly Gly Phe Phe Leu Phe Val Phe Arg Cys Pro Pro Asp Tyr Pro Ile 
145                 150                 155                 160 
His Pro Pro Arg Val Lys Leu Met Thr Thr Gly Asn Asn Thr Val Arg 
                165                 170                 175     
Phe Asn Pro Asn Phe Tyr Arg Asn Gly Lys Val Cys Leu Ser Ile Leu 
            180                 185                 190         
Gly Thr Trp Thr Gly Pro Ala Trp Ser Pro Ala Gln Ser Ile Ser Ser 
        195                 200                 205             
Val Leu Ile Ser Ile Gln Ser Leu Met Thr Glu Asn Pro Tyr His Asn 
    210                 215                 220                 
Glu Pro Gly Phe Glu Gln Glu Arg His Pro Gly Asp Ser Lys Asn Tyr 
225                 230                 235                 240 
Asn Glu Cys Ile Arg His Glu Thr Ile Arg Val Ala Val Cys Asp Met 
                245                 250                 255     
Met Glu Gly Lys Cys Pro Cys Pro Glu Pro Leu Arg Gly Val Met Glu 
            260                 265                 270         
Lys Ser Phe Leu Glu Tyr Tyr Asp Phe Tyr Glu Val Ala Cys Lys Asp 
        275                 280                 285             
Arg Leu His Leu Gln Gly Gln Thr Met Gln Asp Pro Phe Gly Glu Lys 
    290                 295                 300                 
Arg Gly His Phe Asp Tyr Gln Ser Leu Leu Met Arg Leu Gly Leu Ile 
305                 310                 315                 320 
Arg Gln Lys Val Leu Glu Arg Leu His Asn Glu Asn Ala Glu Met Asp 
                325                 330                 335     
Ser Asp Ser Ser Ser Ser Gly Thr Glu Thr Asp Leu His Gly Ser Leu 
            340                 345                 350         
Arg Val 
        

<210> 37
<211> 471
<212> PRT
<213> Homo sapiens


<220> 
<223> UEVLD E2 domain

<400> 37
Met Glu Phe Asp Cys Glu Gly Leu Arg Arg Leu Leu Gly Lys Tyr Lys 
1               5                   10                  15      
Phe Arg Asp Leu Thr Val Glu Glu Leu Arg Asn Val Asn Val Phe Phe 
            20                  25                  30          
Pro His Phe Lys Tyr Ser Met Asp Thr Tyr Val Phe Lys Asp Ser Ser 
        35                  40                  45              
Gln Lys Asp Leu Leu Asn Phe Thr Gly Thr Ile Pro Val Met Tyr Gln 
    50                  55                  60                  
Gly Asn Thr Tyr Asn Ile Pro Ile Arg Phe Trp Ile Leu Asp Ser His 
65                  70                  75                  80  
Pro Phe Ala Pro Pro Ile Cys Phe Leu Lys Pro Thr Ala Asn Met Gly 
                85                  90                  95      
Ile Leu Val Gly Lys His Val Asp Ala Gln Gly Arg Ile Tyr Leu Pro 
            100                 105                 110         
Tyr Leu Gln Asn Trp Ser His Pro Lys Ser Val Ile Val Gly Leu Ile 
        115                 120                 125             
Lys Glu Met Ile Ala Lys Phe Gln Glu Glu Leu Pro Met Tyr Ser Leu 
    130                 135                 140                 
Ser Ser Ser Asp Glu Ala Arg Gln Val Asp Leu Leu Ala Tyr Ile Ala 
145                 150                 155                 160 
Lys Ile Thr Glu Gly Val Ser Asp Thr Asn Ser Lys Ser Trp Ala Asn 
                165                 170                 175     
His Glu Asn Lys Thr Val Asn Lys Ile Thr Val Val Gly Gly Gly Glu 
            180                 185                 190         
Leu Gly Ile Ala Cys Thr Leu Ala Ile Ser Ala Lys Gly Ile Ala Asp 
        195                 200                 205             
Arg Leu Val Leu Leu Asp Leu Ser Glu Gly Thr Lys Gly Ala Thr Met 
    210                 215                 220                 
Asp Leu Glu Ile Phe Asn Leu Pro Asn Val Glu Ile Ser Lys Asp Leu 
225                 230                 235                 240 
Ser Ala Ser Ala His Ser Lys Val Val Ile Phe Thr Val Asn Ser Leu 
                245                 250                 255     
Gly Ser Ser Gln Ser Tyr Leu Asp Val Val Gln Ser Asn Val Asp Met 
            260                 265                 270         
Phe Arg Ala Leu Val Pro Ala Leu Gly His Tyr Ser Gln His Ser Val 
        275                 280                 285             
Leu Leu Val Ala Ser Gln Pro Val Glu Ile Met Thr Tyr Val Thr Trp 
    290                 295                 300                 
Lys Leu Ser Thr Phe Pro Ala Asn Arg Val Ile Gly Ile Gly Cys Asn 
305                 310                 315                 320 
Leu Asp Ser Gln Arg Leu Gln Tyr Ile Ile Thr Asn Val Leu Lys Ala 
                325                 330                 335     
Gln Thr Ser Gly Lys Glu Val Trp Val Ile Gly Glu Gln Gly Glu Asp 
            340                 345                 350         
Lys Val Leu Thr Trp Ser Gly Gln Glu Glu Val Val Ser His Thr Ser 
        355                 360                 365             
Gln Val Gln Leu Ser Asn Arg Ala Met Glu Leu Leu Arg Val Lys Gly 
    370                 375                 380                 
Gln Arg Ser Trp Ser Val Gly Leu Ser Val Ala Asp Met Val Asp Ser 
385                 390                 395                 400 
Ile Val Asn Asn Lys Lys Lys Val His Ser Val Ser Ala Leu Ala Lys 
                405                 410                 415     
Gly Tyr Tyr Asp Ile Asn Ser Glu Val Phe Leu Ser Leu Pro Cys Ile 
            420                 425                 430         
Leu Gly Thr Asn Gly Val Ser Glu Val Ile Lys Thr Thr Leu Lys Glu 
        435                 440                 445             
Asp Thr Val Thr Glu Lys Leu Gln Ser Ser Ala Ser Ser Ile His Ser 
    450                 455                 460                 
Leu Gln Gln Gln Leu Lys Leu 
465                 470     

<210> 38
<211> 4857
<212> PRT
<213> Homo sapiens


<220> 
<223> BIRC6 E2 domain

<400> 38
Met Val Thr Gly Gly Gly Ala Ala Pro Pro Gly Thr Val Thr Glu Pro 
1               5                   10                  15      
Leu Pro Ser Val Ile Val Leu Ser Ala Gly Arg Lys Met Ala Ala Ala 
            20                  25                  30          
Ala Ala Ala Ala Ser Gly Pro Gly Cys Ser Ser Ala Ala Gly Ala Gly 
        35                  40                  45              
Ala Ala Gly Val Ser Glu Trp Leu Val Leu Arg Asp Gly Cys Met His 
    50                  55                  60                  
Cys Asp Ala Asp Gly Leu His Ser Leu Ser Tyr His Pro Ala Leu Asn 
65                  70                  75                  80  
Ala Ile Leu Ala Val Thr Ser Arg Gly Thr Ile Lys Val Ile Asp Gly 
                85                  90                  95      
Thr Ser Gly Ala Thr Leu Gln Ala Ser Ala Leu Ser Ala Lys Pro Gly 
            100                 105                 110         
Gly Gln Val Lys Cys Gln Tyr Ile Ser Ala Val Asp Lys Val Ile Phe 
        115                 120                 125             
Val Asp Asp Tyr Ala Val Gly Cys Arg Lys Asp Leu Asn Gly Ile Leu 
    130                 135                 140                 
Leu Leu Asp Thr Ala Leu Gln Thr Pro Val Ser Lys Gln Asp Asp Val 
145                 150                 155                 160 
Val Gln Leu Glu Leu Pro Val Thr Glu Ala Gln Gln Leu Leu Ser Ala 
                165                 170                 175     
Cys Leu Glu Lys Val Asp Ile Ser Ser Thr Glu Gly Tyr Asp Leu Phe 
            180                 185                 190         
Ile Thr Gln Leu Lys Asp Gly Leu Lys Asn Thr Ser His Glu Thr Ala 
        195                 200                 205             
Ala Asn His Lys Val Ala Lys Trp Ala Thr Val Thr Phe His Leu Pro 
    210                 215                 220                 
His His Val Leu Lys Ser Ile Ala Ser Ala Ile Val Asn Glu Leu Lys 
225                 230                 235                 240 
Lys Ile Asn Gln Asn Val Ala Ala Leu Pro Val Ala Ser Ser Val Met 
                245                 250                 255     
Asp Arg Leu Ser Tyr Leu Leu Pro Ser Ala Arg Pro Glu Leu Gly Val 
            260                 265                 270         
Gly Pro Gly Arg Ser Val Asp Arg Ser Leu Met Tyr Ser Glu Ala Asn 
        275                 280                 285             
Arg Arg Glu Thr Phe Thr Ser Trp Pro His Val Gly Tyr Arg Trp Ala 
    290                 295                 300                 
Gln Pro Asp Pro Met Ala Gln Ala Gly Phe Tyr His Gln Pro Ala Ser 
305                 310                 315                 320 
Ser Gly Asp Asp Arg Ala Met Cys Phe Thr Cys Ser Val Cys Leu Val 
                325                 330                 335     
Cys Trp Glu Pro Thr Asp Glu Pro Trp Ser Glu His Glu Arg His Ser 
            340                 345                 350         
Pro Asn Cys Pro Phe Val Lys Gly Glu His Thr Gln Asn Val Pro Leu 
        355                 360                 365             
Ser Val Thr Leu Ala Thr Ser Pro Ala Gln Phe Pro Cys Thr Asp Gly 
    370                 375                 380                 
Thr Asp Arg Ile Ser Cys Phe Gly Ser Gly Ser Cys Pro His Phe Leu 
385                 390                 395                 400 
Ala Ala Ala Thr Lys Arg Gly Lys Ile Cys Ile Trp Asp Val Ser Lys 
                405                 410                 415     
Leu Met Lys Val His Leu Lys Phe Glu Ile Asn Ala Tyr Asp Pro Ala 
            420                 425                 430         
Ile Val Gln Gln Leu Ile Leu Ser Gly Asp Pro Ser Ser Gly Val Asp 
        435                 440                 445             
Ser Arg Arg Pro Thr Leu Ala Trp Leu Glu Asp Ser Ser Ser Cys Ser 
    450                 455                 460                 
Asp Ile Pro Lys Leu Glu Gly Asp Ser Asp Asp Leu Leu Glu Asp Ser 
465                 470                 475                 480 
Asp Ser Glu Glu His Ser Arg Ser Asp Ser Val Thr Gly His Thr Ser 
                485                 490                 495     
Gln Lys Glu Ala Met Glu Val Ser Leu Asp Ile Thr Ala Leu Ser Ile 
            500                 505                 510         
Leu Gln Gln Pro Glu Lys Leu Gln Trp Glu Ile Val Ala Asn Val Leu 
        515                 520                 525             
Glu Asp Thr Val Lys Asp Leu Glu Glu Leu Gly Ala Asn Pro Cys Leu 
    530                 535                 540                 
Thr Asn Ser Lys Ser Glu Lys Thr Lys Glu Lys His Gln Glu Gln His 
545                 550                 555                 560 
Asn Ile Pro Phe Pro Cys Leu Leu Ala Gly Gly Leu Leu Thr Tyr Lys 
                565                 570                 575     
Ser Pro Ala Thr Ser Pro Ile Ser Ser Asn Ser His Arg Ser Leu Asp 
            580                 585                 590         
Gly Leu Ser Arg Thr Gln Gly Glu Ser Ile Ser Glu Gln Gly Ser Thr 
        595                 600                 605             
Asp Asn Glu Ser Cys Thr Asn Ser Glu Leu Asn Ser Pro Leu Val Arg 
    610                 615                 620                 
Arg Thr Leu Pro Val Leu Leu Leu Tyr Ser Ile Lys Glu Ser Asp Glu 
625                 630                 635                 640 
Lys Ala Gly Lys Ile Phe Ser Gln Met Asn Asn Ile Met Ser Lys Ser 
                645                 650                 655     
Leu His Asp Asp Gly Phe Thr Val Pro Gln Ile Ile Glu Met Glu Leu 
            660                 665                 670         
Asp Ser Gln Glu Gln Leu Leu Leu Gln Asp Pro Pro Val Thr Tyr Ile 
        675                 680                 685             
Gln Gln Phe Ala Asp Ala Ala Ala Asn Leu Thr Ser Pro Asp Ser Glu 
    690                 695                 700                 
Lys Trp Asn Ser Val Phe Pro Lys Pro Gly Thr Leu Val Gln Cys Leu 
705                 710                 715                 720 
Arg Leu Pro Lys Phe Ala Glu Glu Glu Asn Leu Cys Ile Asp Ser Ile 
                725                 730                 735     
Thr Pro Cys Ala Asp Gly Ile His Leu Leu Val Gly Leu Arg Thr Cys 
            740                 745                 750         
Pro Val Glu Ser Leu Ser Ala Ile Asn Gln Val Glu Ala Leu Asn Asn 
        755                 760                 765             
Leu Asn Lys Leu Asn Ser Ala Leu Cys Asn Arg Arg Lys Gly Glu Leu 
    770                 775                 780                 
Glu Ser Asn Leu Ala Val Val Asn Gly Ala Asn Ile Ser Val Ile Gln 
785                 790                 795                 800 
His Glu Ser Pro Ala Asp Val Gln Thr Pro Leu Ile Ile Gln Pro Glu 
                805                 810                 815     
Gln Arg Asn Val Ser Gly Gly Tyr Leu Val Leu Tyr Lys Met Asn Tyr 
            820                 825                 830         
Ala Thr Arg Ile Val Thr Leu Glu Glu Glu Pro Ile Lys Ile Gln His 
        835                 840                 845             
Ile Lys Asp Pro Gln Asp Thr Ile Thr Ser Leu Ile Leu Leu Pro Pro 
    850                 855                 860                 
Asp Ile Leu Asp Asn Arg Glu Asp Asp Cys Glu Glu Pro Ile Glu Asp 
865                 870                 875                 880 
Met Gln Leu Thr Ser Lys Asn Gly Phe Glu Arg Glu Lys Thr Ser Asp 
                885                 890                 895     
Ile Ser Thr Leu Gly His Leu Val Ile Thr Thr Gln Gly Gly Tyr Val 
            900                 905                 910         
Lys Ile Leu Asp Leu Ser Asn Phe Glu Ile Leu Ala Lys Val Glu Pro 
        915                 920                 925             
Pro Lys Lys Glu Gly Thr Glu Glu Gln Asp Thr Phe Val Ser Val Ile 
    930                 935                 940                 
Tyr Cys Ser Gly Thr Asp Arg Leu Cys Ala Cys Thr Lys Gly Gly Glu 
945                 950                 955                 960 
Leu His Phe Leu Gln Ile Gly Gly Thr Cys Asp Asp Ile Asp Glu Ala 
                965                 970                 975     
Asp Ile Leu Val Asp Gly Ser Leu Ser Lys Gly Ile Glu Pro Ser Ser 
            980                 985                 990         
Glu Gly Ser Lys Pro Leu Ser Asn Pro Ser Ser Pro Gly Ile Ser Gly 
        995                 1000                1005            
Val Asp Leu Leu Val Asp Gln Pro Phe Thr Leu Glu Ile Leu Thr Ser 
    1010                1015                1020                
Leu Val Glu Leu Thr Arg Phe Glu Thr Leu Thr Pro Arg Phe Ser Ala 
1025                1030                1035                1040
Thr Val Pro Pro Cys Trp Val Glu Val Gln Gln Glu Gln Gln Gln Arg 
                1045                1050                1055    
Arg His Pro Gln His Leu His Gln Gln His His Gly Asp Ala Ala Gln 
            1060                1065                1070        
His Thr Arg Thr Trp Lys Leu Gln Thr Asp Ser Asn Ser Trp Asp Glu 
        1075                1080                1085            
His Val Phe Glu Leu Val Leu Pro Lys Ala Cys Met Val Gly His Val 
    1090                1095                1100                
Asp Phe Lys Phe Val Leu Asn Ser Asn Ile Thr Asn Ile Pro Gln Ile 
1105                1110                1115                1120
Gln Val Thr Leu Leu Lys Asn Lys Ala Pro Gly Leu Gly Lys Val Asn 
                1125                1130                1135    
Ala Leu Asn Ile Glu Val Glu Gln Asn Gly Lys Pro Ser Leu Val Asp 
            1140                1145                1150        
Leu Asn Glu Glu Met Gln His Met Asp Val Glu Glu Ser Gln Cys Leu 
        1155                1160                1165            
Arg Leu Cys Pro Phe Leu Glu Asp His Lys Glu Asp Ile Leu Cys Gly 
    1170                1175                1180                
Pro Val Trp Leu Ala Ser Gly Leu Asp Leu Ser Gly His Ala Gly Met 
1185                1190                1195                1200
Leu Thr Leu Thr Ser Pro Lys Leu Val Lys Gly Met Ala Gly Gly Lys 
                1205                1210                1215    
Tyr Arg Ser Phe Leu Ile His Val Lys Ala Val Asn Glu Arg Gly Thr 
            1220                1225                1230        
Glu Glu Ile Cys Asn Gly Gly Met Arg Pro Val Val Arg Leu Pro Ser 
        1235                1240                1245            
Leu Lys His Gln Ser Asn Lys Gly Tyr Ser Leu Ala Ser Leu Leu Ala 
    1250                1255                1260                
Lys Val Ala Ala Gly Lys Glu Lys Ser Ser Asn Val Lys Asn Glu Asn 
1265                1270                1275                1280
Thr Ser Gly Thr Arg Lys Ser Glu Asn Leu Arg Gly Cys Asp Leu Leu 
                1285                1290                1295    
Gln Glu Val Ser Val Thr Ile Arg Arg Phe Lys Lys Thr Ser Ile Ser 
            1300                1305                1310        
Lys Glu Arg Val Gln Arg Cys Ala Met Leu Gln Phe Ser Glu Phe His 
        1315                1320                1325            
Glu Lys Leu Val Asn Thr Leu Cys Arg Lys Thr Asp Asp Gly Gln Ile 
    1330                1335                1340                
Thr Glu His Ala Gln Ser Leu Val Leu Asp Thr Leu Cys Trp Leu Ala 
1345                1350                1355                1360
Gly Val His Ser Asn Gly Pro Gly Ser Ser Lys Glu Gly Asn Glu Asn 
                1365                1370                1375    
Leu Leu Ser Lys Thr Arg Lys Phe Leu Ser Asp Ile Val Arg Val Cys 
            1380                1385                1390        
Phe Phe Glu Ala Gly Arg Ser Ile Ala His Lys Cys Ala Arg Phe Leu 
        1395                1400                1405            
Ala Leu Cys Ile Ser Asn Gly Lys Cys Asp Pro Cys Gln Pro Ala Phe 
    1410                1415                1420                
Gly Pro Val Leu Leu Lys Ala Leu Leu Asp Asn Met Ser Phe Leu Pro 
1425                1430                1435                1440
Ala Ala Thr Thr Gly Gly Ser Val Tyr Trp Tyr Phe Val Leu Leu Asn 
                1445                1450                1455    
Tyr Val Lys Asp Glu Asp Leu Ala Gly Cys Ser Thr Ala Cys Ala Ser 
            1460                1465                1470        
Leu Leu Thr Ala Val Ser Arg Gln Leu Gln Asp Arg Leu Thr Pro Met 
        1475                1480                1485            
Glu Ala Leu Leu Gln Thr Arg Tyr Gly Leu Tyr Ser Ser Pro Phe Asp 
    1490                1495                1500                
Pro Val Leu Phe Asp Leu Glu Met Ser Gly Ser Ser Cys Lys Asn Val 
1505                1510                1515                1520
Tyr Asn Ser Ser Ile Gly Val Gln Ser Asp Glu Ile Asp Leu Ser Asp 
                1525                1530                1535    
Val Leu Ser Gly Asn Gly Lys Val Ser Ser Cys Thr Ala Ala Glu Gly 
            1540                1545                1550        
Ser Phe Thr Ser Leu Thr Gly Leu Leu Glu Val Glu Pro Leu His Phe 
        1555                1560                1565            
Thr Cys Val Ser Thr Ser Asp Gly Thr Arg Ile Glu Arg Asp Asp Ala 
    1570                1575                1580                
Met Ser Ser Phe Gly Val Thr Pro Ala Val Gly Gly Leu Ser Ser Gly 
1585                1590                1595                1600
Thr Val Gly Glu Ala Ser Thr Ala Leu Ser Ser Ala Ala Gln Val Ala 
                1605                1610                1615    
Leu Gln Ser Leu Ser His Ala Met Ala Ser Ala Glu Gln Gln Leu Gln 
            1620                1625                1630        
Val Leu Gln Glu Lys Gln Gln Gln Leu Leu Lys Leu Gln Gln Gln Lys 
        1635                1640                1645            
Ala Lys Leu Glu Ala Lys Leu His Gln Thr Thr Ala Ala Ala Ala Ala 
    1650                1655                1660                
Ala Ala Ser Ala Val Gly Pro Val His Asn Ser Val Pro Ser Asn Pro 
1665                1670                1675                1680
Val Ala Ala Pro Gly Phe Phe Ile His Pro Ser Asp Val Ile Pro Pro 
                1685                1690                1695    
Thr Pro Lys Thr Thr Pro Leu Phe Met Thr Pro Pro Leu Thr Pro Pro 
            1700                1705                1710        
Asn Glu Ala Val Ser Val Val Ile Asn Ala Glu Leu Ala Gln Leu Phe 
        1715                1720                1725            
Pro Gly Ser Val Ile Asp Pro Pro Ala Val Asn Leu Ala Ala His Asn 
    1730                1735                1740                
Lys Asn Ser Asn Lys Ser Arg Met Asn Pro Leu Gly Ser Gly Leu Ala 
1745                1750                1755                1760
Leu Ala Ile Ser His Ala Ser His Phe Leu Gln Pro Pro Pro His Gln 
                1765                1770                1775    
Ser Ile Ile Ile Glu Arg Met His Ser Gly Ala Arg Arg Phe Val Thr 
            1780                1785                1790        
Leu Asp Phe Gly Arg Pro Ile Leu Leu Thr Asp Val Leu Ile Pro Thr 
        1795                1800                1805            
Cys Gly Asp Leu Ala Ser Leu Ser Ile Asp Ile Trp Thr Leu Gly Glu 
    1810                1815                1820                
Glu Val Asp Gly Arg Arg Leu Val Val Ala Thr Asp Ile Ser Thr His 
1825                1830                1835                1840
Ser Leu Ile Leu His Asp Leu Ile Pro Pro Pro Val Cys Arg Phe Met 
                1845                1850                1855    
Lys Ile Thr Val Ile Gly Arg Tyr Gly Ser Thr Asn Ala Arg Ala Lys 
            1860                1865                1870        
Ile Pro Leu Gly Phe Tyr Tyr Gly His Thr Tyr Ile Leu Pro Trp Glu 
        1875                1880                1885            
Ser Glu Leu Lys Leu Met His Asp Pro Leu Lys Gly Glu Gly Glu Ser 
    1890                1895                1900                
Ala Asn Gln Pro Glu Ile Asp Gln His Leu Ala Met Met Val Ala Leu 
1905                1910                1915                1920
Gln Glu Asp Ile Gln Cys Arg Tyr Asn Leu Ala Cys His Arg Leu Glu 
                1925                1930                1935    
Thr Leu Leu Gln Ser Ile Asp Leu Pro Pro Leu Asn Ser Ala Asn Asn 
            1940                1945                1950        
Ala Gln Tyr Phe Leu Arg Lys Pro Asp Lys Ala Val Glu Glu Asp Ser 
        1955                1960                1965            
Arg Val Phe Ser Ala Tyr Gln Asp Cys Ile Gln Leu Gln Leu Gln Leu 
    1970                1975                1980                
Asn Leu Ala His Asn Ala Val Gln Arg Leu Lys Val Ala Leu Gly Ala 
1985                1990                1995                2000
Ser Arg Lys Met Leu Ser Glu Thr Ser Asn Pro Glu Asp Leu Ile Gln 
                2005                2010                2015    
Thr Ser Ser Thr Glu Gln Leu Arg Thr Ile Ile Arg Tyr Leu Leu Asp 
            2020                2025                2030        
Thr Leu Leu Ser Leu Leu His Ala Ser Asn Gly His Ser Val Pro Ala 
        2035                2040                2045            
Val Leu Gln Ser Thr Phe His Ala Gln Ala Cys Glu Glu Leu Phe Lys 
    2050                2055                2060                
His Leu Cys Ile Ser Gly Thr Pro Lys Ile Arg Leu His Thr Gly Leu 
2065                2070                2075                2080
Leu Leu Val Gln Leu Cys Gly Gly Glu Arg Trp Trp Gly Gln Phe Leu 
                2085                2090                2095    
Ser Asn Val Leu Gln Glu Leu Tyr Asn Ser Glu Gln Leu Leu Ile Phe 
            2100                2105                2110        
Pro Gln Asp Arg Val Phe Met Leu Leu Ser Cys Ile Gly Gln Arg Ser 
        2115                2120                2125            
Leu Ser Asn Ser Gly Val Leu Glu Ser Leu Leu Asn Leu Leu Asp Asn 
    2130                2135                2140                
Leu Leu Ser Pro Leu Gln Pro Gln Leu Pro Met His Arg Arg Thr Glu 
2145                2150                2155                2160
Gly Val Leu Asp Ile Pro Met Ile Ser Trp Val Val Met Leu Val Ser 
                2165                2170                2175    
Arg Leu Leu Asp Tyr Val Ala Thr Val Glu Asp Glu Ala Ala Ala Ala 
            2180                2185                2190        
Lys Lys Pro Leu Asn Gly Asn Gln Trp Ser Phe Ile Asn Asn Asn Leu 
        2195                2200                2205            
His Thr Gln Ser Leu Asn Arg Ser Ser Lys Gly Ser Ser Ser Leu Asp 
    2210                2215                2220                
Arg Leu Tyr Ser Arg Lys Ile Arg Lys Gln Leu Val His His Lys Gln 
2225                2230                2235                2240
Gln Leu Asn Leu Leu Lys Ala Lys Gln Lys Ala Leu Val Glu Gln Met 
                2245                2250                2255    
Glu Lys Glu Lys Ile Gln Ser Asn Lys Gly Ser Ser Tyr Lys Leu Leu 
            2260                2265                2270        
Val Glu Gln Ala Lys Leu Lys Gln Ala Thr Ser Lys His Phe Lys Asp 
        2275                2280                2285            
Leu Ile Arg Leu Arg Arg Thr Ala Glu Trp Ser Arg Ser Asn Leu Asp 
    2290                2295                2300                
Thr Glu Val Thr Thr Ala Lys Glu Ser Pro Glu Ile Glu Pro Leu Pro 
2305                2310                2315                2320
Phe Thr Leu Ala His Glu Arg Cys Ile Ser Val Val Gln Lys Leu Val 
                2325                2330                2335    
Leu Phe Leu Leu Ser Met Asp Phe Thr Cys His Ala Asp Leu Leu Leu 
            2340                2345                2350        
Phe Val Cys Lys Val Leu Ala Arg Ile Ala Asn Ala Thr Arg Pro Thr 
        2355                2360                2365            
Ile His Leu Cys Glu Ile Val Asn Glu Pro Gln Leu Glu Arg Leu Leu 
    2370                2375                2380                
Leu Leu Leu Val Gly Thr Asp Phe Asn Arg Gly Asp Ile Ser Trp Gly 
2385                2390                2395                2400
Gly Ala Trp Ala Gln Tyr Ser Leu Thr Cys Met Leu Gln Asp Ile Leu 
                2405                2410                2415    
Ala Gly Glu Leu Leu Ala Pro Val Ala Ala Glu Ala Met Glu Glu Gly 
            2420                2425                2430        
Thr Val Gly Asp Asp Val Gly Ala Thr Ala Gly Asp Ser Asp Asp Ser 
        2435                2440                2445            
Leu Gln Gln Ser Ser Val Gln Leu Leu Glu Thr Ile Asp Glu Pro Leu 
    2450                2455                2460                
Thr His Asp Ile Thr Gly Ala Pro Pro Leu Ser Ser Leu Glu Lys Asp 
2465                2470                2475                2480
Lys Glu Ile Asp Leu Glu Leu Leu Gln Asp Leu Met Glu Val Asp Ile 
                2485                2490                2495    
Asp Pro Leu Asp Ile Asp Leu Glu Lys Asp Pro Leu Ala Ala Lys Val 
            2500                2505                2510        
Phe Lys Pro Ile Ser Ser Thr Trp Tyr Asp Tyr Trp Gly Ala Asp Tyr 
        2515                2520                2525            
Gly Thr Tyr Asn Tyr Asn Pro Tyr Ile Gly Gly Leu Gly Ile Pro Val 
    2530                2535                2540                
Ala Lys Pro Pro Ala Asn Thr Glu Lys Asn Gly Ser Gln Thr Val Ser 
2545                2550                2555                2560
Val Ser Val Ser Gln Ala Leu Asp Ala Arg Leu Glu Val Gly Leu Glu 
                2565                2570                2575    
Gln Gln Ala Glu Leu Met Leu Lys Met Met Ser Thr Leu Glu Ala Asp 
            2580                2585                2590        
Ser Ile Leu Gln Ala Leu Thr Asn Thr Ser Pro Thr Leu Ser Gln Ser 
        2595                2600                2605            
Pro Thr Gly Thr Asp Asp Ser Leu Leu Gly Gly Leu Gln Ala Ala Asn 
    2610                2615                2620                
Gln Thr Ser Gln Leu Ile Ile Gln Leu Ser Ser Val Pro Met Leu Asn 
2625                2630                2635                2640
Val Cys Phe Asn Lys Leu Phe Ser Met Leu Gln Val His His Val Gln 
                2645                2650                2655    
Leu Glu Ser Leu Leu Gln Leu Trp Leu Thr Leu Ser Leu Asn Ser Ser 
            2660                2665                2670        
Ser Thr Gly Asn Lys Glu Asn Gly Ala Asp Ile Phe Leu Tyr Asn Ala 
        2675                2680                2685            
Asn Arg Ile Pro Val Ile Ser Leu Asn Gln Ala Ser Ile Thr Ser Phe 
    2690                2695                2700                
Leu Thr Val Leu Ala Trp Tyr Pro Asn Thr Leu Leu Arg Thr Trp Cys 
2705                2710                2715                2720
Leu Val Leu His Ser Leu Thr Leu Met Thr Asn Met Gln Leu Asn Ser 
                2725                2730                2735    
Gly Ser Ser Ser Ala Ile Gly Thr Gln Glu Ser Thr Ala His Leu Leu 
            2740                2745                2750        
Val Ser Asp Pro Asn Leu Ile His Val Leu Val Lys Phe Leu Ser Gly 
        2755                2760                2765            
Thr Ser Pro His Gly Thr Asn Gln His Ser Pro Gln Val Gly Pro Thr 
    2770                2775                2780                
Ala Thr Gln Ala Met Gln Glu Phe Leu Thr Arg Leu Gln Val His Leu 
2785                2790                2795                2800
Ser Ser Thr Cys Pro Gln Ile Phe Ser Glu Phe Leu Leu Lys Leu Ile 
                2805                2810                2815    
His Ile Leu Ser Thr Glu Arg Gly Ala Phe Gln Thr Gly Gln Gly Pro 
            2820                2825                2830        
Leu Asp Ala Gln Val Lys Leu Leu Glu Phe Thr Leu Glu Gln Asn Phe 
        2835                2840                2845            
Glu Val Val Ser Val Ser Thr Ile Ser Ala Val Ile Glu Ser Val Thr 
    2850                2855                2860                
Phe Leu Val His His Tyr Ile Thr Cys Ser Asp Lys Val Met Ser Arg 
2865                2870                2875                2880
Ser Gly Ser Asp Ser Ser Val Gly Ala Arg Ala Cys Phe Gly Gly Leu 
                2885                2890                2895    
Phe Ala Asn Leu Ile Arg Pro Gly Asp Ala Lys Ala Val Cys Gly Glu 
            2900                2905                2910        
Met Thr Arg Asp Gln Leu Met Phe Asp Leu Leu Lys Leu Val Asn Ile 
        2915                2920                2925            
Leu Val Gln Leu Pro Leu Ser Gly Asn Arg Glu Tyr Ser Ala Arg Val 
    2930                2935                2940                
Ser Val Thr Thr Asn Thr Thr Asp Ser Val Ser Asp Glu Glu Lys Val 
2945                2950                2955                2960
Ser Gly Gly Lys Asp Gly Asn Gly Ser Ser Thr Ser Val Gln Gly Ser 
                2965                2970                2975    
Pro Ala Tyr Val Ala Asp Leu Val Leu Ala Asn Gln Gln Ile Met Ser 
            2980                2985                2990        
Gln Ile Leu Ser Ala Leu Gly Leu Cys Asn Ser Ser Ala Met Ala Met 
        2995                3000                3005            
Ile Ile Gly Ala Ser Gly Leu His Leu Thr Lys His Glu Asn Phe His 
    3010                3015                3020                
Gly Gly Leu Asp Ala Ile Ser Val Gly Asp Gly Leu Phe Thr Ile Leu 
3025                3030                3035                3040
Thr Thr Leu Ser Lys Lys Ala Ser Thr Val His Met Met Leu Gln Pro 
                3045                3050                3055    
Ile Leu Thr Tyr Met Ala Cys Gly Tyr Met Gly Arg Gln Gly Ser Leu 
            3060                3065                3070        
Ala Thr Cys Gln Leu Ser Glu Pro Leu Leu Trp Phe Ile Leu Arg Val 
        3075                3080                3085            
Leu Asp Thr Ser Asp Ala Leu Lys Ala Phe His Asp Met Gly Gly Val 
    3090                3095                3100                
Gln Leu Ile Cys Asn Asn Met Val Thr Ser Thr Arg Ala Ile Val Asn 
3105                3110                3115                3120
Thr Ala Arg Ser Met Val Ser Thr Ile Met Lys Phe Leu Asp Ser Gly 
                3125                3130                3135    
Pro Asn Lys Ala Val Asp Ser Thr Leu Lys Thr Arg Ile Leu Ala Ser 
            3140                3145                3150        
Glu Pro Asp Asn Ala Glu Gly Ile His Asn Phe Ala Pro Leu Gly Thr 
        3155                3160                3165            
Ile Thr Ser Ser Ser Pro Thr Ala Gln Pro Ala Glu Val Leu Leu Gln 
    3170                3175                3180                
Ala Thr Pro Pro His Arg Arg Ala Arg Ser Ala Ala Trp Ser Tyr Ile 
3185                3190                3195                3200
Phe Leu Pro Glu Glu Ala Trp Cys Asp Leu Thr Ile His Leu Pro Ala 
                3205                3210                3215    
Ala Val Leu Leu Lys Glu Ile His Ile Gln Pro His Leu Ala Ser Leu 
            3220                3225                3230        
Ala Thr Cys Pro Ser Ser Val Ser Val Glu Val Ser Ala Asp Gly Val 
        3235                3240                3245            
Asn Met Leu Pro Leu Ser Thr Pro Val Val Thr Ser Gly Leu Thr Tyr 
    3250                3255                3260                
Ile Lys Ile Gln Leu Val Lys Ala Glu Val Ala Ser Ala Val Cys Leu 
3265                3270                3275                3280
Arg Leu His Arg Pro Arg Asp Ala Ser Thr Leu Gly Leu Ser Gln Ile 
                3285                3290                3295    
Lys Leu Leu Gly Leu Thr Ala Phe Gly Thr Thr Ser Ser Ala Thr Val 
            3300                3305                3310        
Asn Asn Pro Phe Leu Pro Ser Glu Asp Gln Val Ser Lys Thr Ser Ile 
        3315                3320                3325            
Gly Trp Leu Arg Leu Leu His His Cys Leu Thr His Ile Ser Asp Leu 
    3330                3335                3340                
Glu Gly Met Met Ala Ser Ala Ala Ala Pro Thr Ala Asn Leu Leu Gln 
3345                3350                3355                3360
Thr Cys Ala Ala Leu Leu Met Ser Pro Tyr Cys Gly Met His Ser Pro 
                3365                3370                3375    
Asn Ile Glu Val Val Leu Val Lys Ile Gly Leu Gln Ser Thr Arg Ile 
            3380                3385                3390        
Gly Leu Lys Leu Ile Asp Ile Leu Leu Arg Asn Cys Ala Ala Ser Gly 
        3395                3400                3405            
Ser Asp Pro Thr Asp Leu Asn Ser Pro Leu Leu Phe Gly Arg Leu Asn 
    3410                3415                3420                
Gly Leu Ser Ser Asp Ser Thr Ile Asp Ile Leu Tyr Gln Leu Gly Thr 
3425                3430                3435                3440
Thr Gln Asp Pro Gly Thr Lys Asp Arg Ile Gln Ala Leu Leu Lys Trp 
                3445                3450                3455    
Val Ser Asp Ser Ala Arg Val Ala Ala Met Lys Arg Ser Gly Arg Met 
            3460                3465                3470        
Asn Tyr Met Cys Pro Asn Ser Ser Thr Val Glu Tyr Gly Leu Leu Met 
        3475                3480                3485            
Pro Ser Pro Ser His Leu His Cys Val Ala Ala Ile Leu Trp His Ser 
    3490                3495                3500                
Tyr Glu Leu Leu Val Glu Tyr Asp Leu Pro Ala Leu Leu Asp Gln Glu 
3505                3510                3515                3520
Leu Phe Glu Leu Leu Phe Asn Trp Ser Met Ser Leu Pro Cys Asn Met 
                3525                3530                3535    
Val Leu Lys Lys Ala Val Asp Ser Leu Leu Cys Ser Met Cys His Val 
            3540                3545                3550        
His Pro Asn Tyr Phe Ser Leu Leu Met Gly Trp Met Gly Ile Thr Pro 
        3555                3560                3565            
Pro Pro Val Gln Cys His His Arg Leu Ser Met Thr Asp Asp Ser Lys 
    3570                3575                3580                
Lys Gln Asp Leu Ser Ser Ser Leu Thr Asp Asp Ser Lys Asn Ala Gln 
3585                3590                3595                3600
Ala Pro Leu Ala Leu Thr Glu Ser His Leu Ala Thr Leu Ala Ser Ser 
                3605                3610                3615    
Ser Gln Ser Pro Glu Ala Ile Lys Gln Leu Leu Asp Ser Gly Leu Pro 
            3620                3625                3630        
Ser Leu Leu Val Arg Ser Leu Ala Ser Phe Cys Phe Ser His Ile Ser 
        3635                3640                3645            
Ser Ser Glu Ser Ile Ala Gln Ser Ile Asp Ile Ser Gln Asp Lys Leu 
    3650                3655                3660                
Arg Arg His His Val Pro Gln Gln Cys Asn Lys Met Pro Ile Thr Ala 
3665                3670                3675                3680
Asp Leu Val Ala Pro Ile Leu Arg Phe Leu Thr Glu Val Gly Asn Ser 
                3685                3690                3695    
His Ile Met Lys Asp Trp Leu Gly Gly Ser Glu Val Asn Pro Leu Trp 
            3700                3705                3710        
Thr Ala Leu Leu Phe Leu Leu Cys His Ser Gly Ser Thr Ser Gly Ser 
        3715                3720                3725            
His Asn Leu Gly Ala Gln Gln Thr Ser Ala Arg Ser Ala Ser Leu Ser 
    3730                3735                3740                
Ser Ala Ala Thr Thr Gly Leu Thr Thr Gln Gln Arg Thr Ala Ile Glu 
3745                3750                3755                3760
Asn Ala Thr Val Ala Phe Phe Leu Gln Cys Ile Ser Cys His Pro Asn 
                3765                3770                3775    
Asn Gln Lys Leu Met Ala Gln Val Leu Cys Glu Leu Phe Gln Thr Ser 
            3780                3785                3790        
Pro Gln Arg Gly Asn Leu Pro Thr Ser Gly Asn Ile Ser Gly Phe Ile 
        3795                3800                3805            
Arg Arg Leu Phe Leu Gln Leu Met Leu Glu Asp Glu Lys Val Thr Met 
    3810                3815                3820                
Phe Leu Gln Ser Pro Cys Pro Leu Tyr Lys Gly Arg Ile Asn Ala Thr 
3825                3830                3835                3840
Ser His Val Ile Gln His Pro Met Tyr Gly Ala Gly His Lys Phe Arg 
                3845                3850                3855    
Thr Leu His Leu Pro Val Ser Thr Thr Leu Ser Asp Val Leu Asp Arg 
            3860                3865                3870        
Val Ser Asp Thr Pro Ser Ile Thr Ala Lys Leu Ile Ser Glu Gln Lys 
        3875                3880                3885            
Asp Asp Lys Glu Lys Lys Asn His Glu Glu Lys Glu Lys Val Lys Ala 
    3890                3895                3900                
Glu Asn Gly Phe Gln Asp Asn Tyr Ser Val Val Val Ala Ser Gly Leu 
3905                3910                3915                3920
Lys Ser Gln Ser Lys Arg Ala Val Ser Ala Thr Pro Pro Arg Pro Pro 
                3925                3930                3935    
Ser Arg Arg Gly Arg Thr Ile Pro Asp Lys Ile Gly Ser Thr Ser Gly 
            3940                3945                3950        
Ala Glu Ala Ala Asn Lys Ile Ile Thr Val Pro Val Phe His Leu Phe 
        3955                3960                3965            
His Lys Leu Leu Ala Gly Gln Pro Leu Pro Ala Glu Met Thr Leu Ala 
    3970                3975                3980                
Gln Leu Leu Thr Leu Leu Tyr Asp Arg Lys Leu Pro Gln Gly Tyr Arg 
3985                3990                3995                4000
Ser Ile Asp Leu Thr Val Lys Leu Gly Ser Arg Val Ile Thr Asp Pro 
                4005                4010                4015    
Ser Leu Ser Lys Thr Asp Ser Tyr Lys Arg Leu His Pro Glu Lys Asp 
            4020                4025                4030        
His Gly Asp Leu Leu Ala Ser Cys Pro Glu Asp Glu Ala Leu Thr Pro 
        4035                4040                4045            
Gly Asp Glu Cys Met Asp Gly Ile Leu Asp Glu Ser Leu Leu Glu Thr 
    4050                4055                4060                
Cys Pro Ile Gln Ser Pro Leu Gln Val Phe Ala Gly Met Gly Gly Leu 
4065                4070                4075                4080
Ala Leu Ile Ala Glu Arg Leu Pro Met Leu Tyr Pro Glu Val Ile Gln 
                4085                4090                4095    
Gln Val Ser Ala Pro Val Val Thr Ser Thr Thr Gln Glu Lys Pro Lys 
            4100                4105                4110        
Asp Ser Asp Gln Phe Glu Trp Val Thr Ile Glu Gln Ser Gly Glu Leu 
        4115                4120                4125            
Val Tyr Glu Ala Pro Glu Thr Val Ala Ala Glu Pro Pro Pro Ile Lys 
    4130                4135                4140                
Ser Ala Val Gln Thr Met Ser Pro Ile Pro Ala His Ser Leu Ala Ala 
4145                4150                4155                4160
Phe Gly Leu Phe Leu Arg Leu Pro Gly Tyr Ala Glu Val Leu Leu Lys 
                4165                4170                4175    
Glu Arg Lys His Ala Gln Cys Leu Leu Arg Leu Val Leu Gly Val Thr 
            4180                4185                4190        
Asp Asp Gly Glu Gly Ser His Ile Leu Gln Ser Pro Ser Ala Asn Val 
        4195                4200                4205            
Leu Pro Thr Leu Pro Phe His Val Leu Arg Ser Leu Phe Ser Thr Thr 
    4210                4215                4220                
Pro Leu Thr Thr Asp Asp Gly Val Leu Leu Arg Arg Met Ala Leu Glu 
4225                4230                4235                4240
Ile Gly Ala Leu His Leu Ile Leu Val Cys Leu Ser Ala Leu Ser His 
                4245                4250                4255    
His Ser Pro Arg Val Pro Asn Ser Ser Val Asn Gln Thr Glu Pro Gln 
            4260                4265                4270        
Val Ser Ser Ser His Asn Pro Thr Ser Thr Glu Glu Gln Gln Leu Tyr 
        4275                4280                4285            
Trp Ala Lys Gly Thr Gly Phe Gly Thr Gly Ser Thr Ala Ser Gly Trp 
    4290                4295                4300                
Asp Val Glu Gln Ala Leu Thr Lys Gln Arg Leu Glu Glu Glu His Val 
4305                4310                4315                4320
Thr Cys Leu Leu Gln Val Leu Ala Ser Tyr Ile Asn Pro Val Ser Ser 
                4325                4330                4335    
Ala Val Asn Gly Glu Ala Gln Ser Ser His Glu Thr Arg Gly Gln Asn 
            4340                4345                4350        
Ser Asn Ala Leu Pro Ser Val Leu Leu Glu Leu Leu Ser Gln Ser Cys 
        4355                4360                4365            
Leu Ile Pro Ala Met Ser Ser Tyr Leu Arg Asn Asp Ser Val Leu Asp 
    4370                4375                4380                
Met Ala Arg His Val Pro Leu Tyr Arg Ala Leu Leu Glu Leu Leu Arg 
4385                4390                4395                4400
Ala Ile Ala Ser Cys Ala Ala Met Val Pro Leu Leu Leu Pro Leu Ser 
                4405                4410                4415    
Thr Glu Asn Gly Glu Glu Glu Glu Glu Gln Ser Glu Cys Gln Thr Ser 
            4420                4425                4430        
Val Gly Thr Leu Leu Ala Lys Met Lys Thr Cys Val Asp Thr Tyr Thr 
        4435                4440                4445            
Asn Arg Leu Arg Ser Lys Arg Glu Asn Val Lys Thr Gly Val Lys Pro 
    4450                4455                4460                
Asp Ala Ser Asp Gln Glu Pro Glu Gly Leu Thr Leu Leu Val Pro Asp 
4465                4470                4475                4480
Ile Gln Lys Thr Ala Glu Ile Val Tyr Ala Ala Thr Thr Ser Leu Arg 
                4485                4490                4495    
Gln Ala Asn Gln Glu Lys Lys Leu Gly Glu Tyr Ser Lys Lys Ala Ala 
            4500                4505                4510        
Met Lys Pro Lys Pro Leu Ser Val Leu Lys Ser Leu Glu Glu Lys Tyr 
        4515                4520                4525            
Val Ala Val Met Lys Lys Leu Gln Phe Asp Thr Phe Glu Met Val Ser 
    4530                4535                4540                
Glu Asp Glu Asp Gly Lys Leu Gly Phe Lys Val Asn Tyr His Tyr Met 
4545                4550                4555                4560
Ser Gln Val Lys Asn Ala Asn Asp Ala Asn Ser Ala Ala Arg Ala Arg 
                4565                4570                4575    
Arg Leu Ala Gln Glu Ala Val Thr Leu Ser Thr Ser Leu Pro Leu Ser 
            4580                4585                4590        
Ser Ser Ser Ser Val Phe Val Arg Cys Asp Glu Glu Arg Leu Asp Ile 
        4595                4600                4605            
Met Lys Val Leu Ile Thr Gly Pro Ala Asp Thr Pro Tyr Ala Asn Gly 
    4610                4615                4620                
Cys Phe Glu Phe Asp Val Tyr Phe Pro Gln Asp Tyr Pro Ser Ser Pro 
4625                4630                4635                4640
Pro Leu Val Asn Leu Glu Thr Thr Gly Gly His Ser Val Arg Phe Asn 
                4645                4650                4655    
Pro Asn Leu Tyr Asn Asp Gly Lys Val Cys Leu Ser Ile Leu Asn Thr 
            4660                4665                4670        
Trp His Gly Arg Pro Glu Glu Lys Trp Asn Pro Gln Thr Ser Ser Phe 
        4675                4680                4685            
Leu Gln Val Leu Val Ser Val Gln Ser Leu Ile Leu Val Ala Glu Pro 
    4690                4695                4700                
Tyr Phe Asn Glu Pro Gly Tyr Glu Arg Ser Arg Gly Thr Pro Ser Gly 
4705                4710                4715                4720
Thr Gln Ser Ser Arg Glu Tyr Asp Gly Asn Ile Arg Gln Ala Thr Val 
                4725                4730                4735    
Lys Trp Ala Met Leu Glu Gln Ile Arg Asn Pro Ser Pro Cys Phe Lys 
            4740                4745                4750        
Glu Val Ile His Lys His Phe Tyr Leu Lys Arg Val Glu Ile Met Ala 
        4755                4760                4765            
Gln Cys Glu Glu Trp Ile Ala Asp Ile Gln Gln Tyr Ser Ser Asp Lys 
    4770                4775                4780                
Arg Val Gly Arg Thr Met Ser His His Ala Ala Ala Leu Lys Arg His 
4785                4790                4795                4800
Thr Ala Gln Leu Arg Glu Glu Leu Leu Lys Leu Pro Cys Pro Glu Gly 
                4805                4810                4815    
Leu Asp Pro Asp Thr Asp Asp Ala Pro Glu Val Cys Arg Ala Thr Thr 
            4820                4825                4830        
Gly Ala Glu Glu Thr Leu Met His Asp Gln Val Lys Pro Ser Ser Ser 
        4835                4840                4845            
Lys Glu Leu Pro Ser Asp Phe Gln Leu 
    4850                4855        

<210> 39
<211> 292
<212> PRT
<213> Homo sapiens


<220> 
<223> FTS E2 domain

<400> 39
Met Asn Pro Phe Trp Ser Met Ser Thr Ser Ser Val Arg Lys Arg Ser 
1               5                   10                  15      
Glu Gly Glu Glu Lys Thr Leu Thr Gly Asp Val Lys Thr Ser Pro Pro 
            20                  25                  30          
Arg Thr Ala Pro Lys Lys Gln Leu Pro Ser Ile Pro Lys Asn Ala Leu 
        35                  40                  45              
Pro Ile Thr Lys Pro Thr Ser Pro Ala Pro Ala Ala Gln Ser Thr Asn 
    50                  55                  60                  
Gly Thr His Ala Ser Tyr Gly Pro Phe Tyr Leu Glu Tyr Ser Leu Leu 
65                  70                  75                  80  
Ala Glu Phe Thr Leu Val Val Lys Gln Lys Leu Pro Gly Val Tyr Val 
                85                  90                  95      
Gln Pro Ser Tyr Arg Ser Ala Leu Met Trp Phe Gly Val Ile Phe Ile 
            100                 105                 110         
Arg His Gly Leu Tyr Gln Asp Gly Val Phe Lys Phe Thr Val Tyr Ile 
        115                 120                 125             
Pro Asp Asn Tyr Pro Asp Gly Asp Cys Pro Arg Leu Val Phe Asp Ile 
    130                 135                 140                 
Pro Val Phe His Pro Leu Val Asp Pro Thr Ser Gly Glu Leu Asp Val 
145                 150                 155                 160 
Lys Arg Ala Phe Ala Lys Trp Arg Arg Asn His Asn His Ile Trp Gln 
                165                 170                 175     
Val Leu Met Tyr Ala Arg Arg Val Phe Tyr Lys Ile Asp Thr Ala Ser 
            180                 185                 190         
Pro Leu Asn Pro Glu Ala Ala Val Leu Tyr Glu Lys Asp Ile Gln Leu 
        195                 200                 205             
Phe Lys Ser Lys Val Val Asp Ser Val Lys Val Cys Thr Ala Arg Leu 
    210                 215                 220                 
Phe Asp Gln Pro Lys Ile Glu Asp Pro Tyr Ala Ile Ser Phe Ser Pro 
225                 230                 235                 240 
Trp Asn Pro Ser Val His Asp Glu Ala Arg Glu Lys Met Leu Thr Gln 
                245                 250                 255     
Lys Lys Pro Glu Glu Gln His Asn Lys Ser Val His Val Ala Gly Leu 
            260                 265                 270         
Ser Trp Val Lys Pro Gly Ser Val Gln Pro Phe Ser Lys Glu Glu Lys 
        275                 280                 285             
Thr Val Ala Thr 
    290         

<210> 40
<211> 390
<212> PRT
<213> Homo sapiens


<220> 
<223> TSG101 E2 domain

<400> 40
Met Ala Val Ser Glu Ser Gln Leu Lys Lys Met Val Ser Lys Tyr Lys 
1               5                   10                  15      
Tyr Arg Asp Leu Thr Val Arg Glu Thr Val Asn Val Ile Thr Leu Tyr 
            20                  25                  30          
Lys Asp Leu Lys Pro Val Leu Asp Ser Tyr Val Phe Asn Asp Gly Ser 
        35                  40                  45              
Ser Arg Glu Leu Met Asn Leu Thr Gly Thr Ile Pro Val Pro Tyr Arg 
    50                  55                  60                  
Gly Asn Thr Tyr Asn Ile Pro Ile Cys Leu Trp Leu Leu Asp Thr Tyr 
65                  70                  75                  80  
Pro Tyr Asn Pro Pro Ile Cys Phe Val Lys Pro Thr Ser Ser Met Thr 
                85                  90                  95      
Ile Lys Thr Gly Lys His Val Asp Ala Asn Gly Lys Ile Tyr Leu Pro 
            100                 105                 110         
Tyr Leu His Glu Trp Lys His Pro Gln Ser Asp Leu Leu Gly Leu Ile 
        115                 120                 125             
Gln Val Met Ile Val Val Phe Gly Asp Glu Pro Pro Val Phe Ser Arg 
    130                 135                 140                 
Pro Ile Ser Ala Ser Tyr Pro Pro Tyr Gln Ala Thr Gly Pro Pro Asn 
145                 150                 155                 160 
Thr Ser Tyr Met Pro Gly Met Pro Gly Gly Ile Ser Pro Tyr Pro Ser 
                165                 170                 175     
Gly Tyr Pro Pro Asn Pro Ser Gly Tyr Pro Gly Cys Pro Tyr Pro Pro 
            180                 185                 190         
Gly Gly Pro Tyr Pro Ala Thr Thr Ser Ser Gln Tyr Pro Ser Gln Pro 
        195                 200                 205             
Pro Val Thr Thr Val Gly Pro Ser Arg Asp Gly Thr Ile Ser Glu Asp 
    210                 215                 220                 
Thr Ile Arg Ala Ser Leu Ile Ser Ala Val Ser Asp Lys Leu Arg Trp 
225                 230                 235                 240 
Arg Met Lys Glu Glu Met Asp Arg Ala Gln Ala Glu Leu Asn Ala Leu 
                245                 250                 255     
Lys Arg Thr Glu Glu Asp Leu Lys Lys Gly His Gln Lys Leu Glu Glu 
            260                 265                 270         
Met Val Thr Arg Leu Asp Gln Glu Val Ala Glu Val Asp Lys Asn Ile 
        275                 280                 285             
Glu Leu Leu Lys Lys Lys Asp Glu Glu Leu Ser Ser Ala Leu Glu Lys 
    290                 295                 300                 
Met Glu Asn Gln Ser Glu Asn Asn Asp Ile Asp Glu Val Ile Ile Pro 
305                 310                 315                 320 
Thr Ala Pro Leu Tyr Lys Gln Ile Leu Asn Leu Tyr Ala Glu Glu Asn 
                325                 330                 335     
Ala Ile Glu Asp Thr Ile Phe Tyr Leu Gly Glu Ala Leu Arg Arg Gly 
            340                 345                 350         
Val Ile Asp Leu Asp Val Phe Leu Lys His Val Arg Leu Leu Ser Arg 
        355                 360                 365             
Lys Gln Phe Gln Leu Arg Ala Leu Met Gln Lys Ala Arg Lys Thr Ala 
    370                 375                 380                 
Gly Leu Ser Asp Leu Tyr 
385                 390 

<210> 41
<211> 167
<212> PRT
<213> Homo sapiens


<220> 
<223> UFC1 E2 domain

<400> 41
Met Ala Asp Glu Ala Thr Arg Arg Val Val Ser Glu Ile Pro Val Leu 
1               5                   10                  15      
Lys Thr Asn Ala Gly Pro Arg Asp Arg Glu Leu Trp Val Gln Arg Leu 
            20                  25                  30          
Lys Glu Glu Tyr Gln Ser Leu Ile Arg Tyr Val Glu Asn Asn Lys Asn 
        35                  40                  45              
Ala Asp Asn Asp Trp Phe Arg Leu Glu Ser Asn Lys Glu Gly Thr Arg 
    50                  55                  60                  
Trp Phe Gly Lys Cys Trp Tyr Ile His Asp Leu Leu Lys Tyr Glu Phe 
65                  70                  75                  80  
Asp Ile Glu Phe Asp Ile Pro Ile Thr Tyr Pro Thr Thr Ala Pro Glu 
                85                  90                  95      
Ile Ala Val Pro Glu Leu Asp Gly Lys Thr Ala Lys Met Tyr Arg Gly 
            100                 105                 110         
Gly Lys Ile Cys Leu Thr Asp His Phe Lys Pro Leu Trp Ala Arg Asn 
        115                 120                 125             
Val Pro Lys Phe Gly Leu Ala His Leu Met Ala Leu Gly Leu Gly Pro 
    130                 135                 140                 
Trp Leu Ala Val Glu Ile Pro Asp Leu Ile Gln Lys Gly Val Ile Gln 
145                 150                 155                 160 
His Lys Glu Lys Cys Asn Gln 
                165         

<210> 42
<211> 151
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2A UBC domain

<400> 42
Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Leu Gln 
1               5                   10                  15      
Glu Asp Pro Pro Ala Gly Val Ser Gly Ala Pro Ser Glu Asn Asn Ile 
            20                  25                  30          
Met Val Trp Asn Ala Val Ile Phe Gly Pro Glu Gly Thr Pro Phe Glu 
        35                  40                  45              
Asp Gly Thr Phe Lys Leu Thr Ile Glu Phe Thr Glu Glu Tyr Pro Asn 
    50                  55                  60                  
Lys Pro Pro Thr Val Arg Phe Val Ser Lys Met Phe His Pro Asn Val 
65                  70                  75                  80  
Tyr Ala Asp Gly Ser Ile Cys Leu Asp Ile Leu Gln Asn Arg Trp Ser 
                85                  90                  95      
Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr Ser Ile Gln Ser Leu Leu 
            100                 105                 110         
Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn Ser Gln Ala Ala Gln Leu 
        115                 120                 125             
Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys Arg Val Ser Ala Ile Val 
    130                 135                 140                 
Glu Gln Ser Trp Arg Asp Cys 
145                 150     

<210> 43
<211> 151
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2B UBC domain

<400> 43
Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Leu Gln 
1               5                   10                  15      
Glu Asp Pro Pro Val Gly Val Ser Gly Ala Pro Ser Glu Asn Asn Ile 
            20                  25                  30          
Met Gln Trp Asn Ala Val Ile Phe Gly Pro Glu Gly Thr Pro Phe Glu 
        35                  40                  45              
Asp Gly Thr Phe Lys Leu Val Ile Glu Phe Ser Glu Glu Tyr Pro Asn 
    50                  55                  60                  
Lys Pro Pro Thr Val Arg Phe Leu Ser Lys Met Phe His Pro Asn Val 
65                  70                  75                  80  
Tyr Ala Asp Gly Ser Ile Cys Leu Asp Ile Leu Gln Asn Arg Trp Ser 
                85                  90                  95      
Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr Ser Ile Gln Ser Leu Leu 
            100                 105                 110         
Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn Ser Gln Ala Ala Gln Leu 
        115                 120                 125             
Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys Arg Val Ser Ala Ile Val 
    130                 135                 140                 
Glu Gln Ser Trp Asn Asp Ser 
145                 150     

<210> 44
<211> 178
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2C UBC domain

<400> 44
Ala Ser Gln Asn Arg Asp Pro Ala Ala Thr Ser Val Ala Ala Ala Arg 
1               5                   10                  15      
Lys Gly Ala Glu Pro Ser Gly Gly Ala Ala Arg Gly Pro Val Gly Lys 
            20                  25                  30          
Arg Leu Gln Gln Glu Leu Met Thr Leu Met Met Ser Gly Asp Lys Gly 
        35                  40                  45              
Ile Ser Ala Phe Pro Glu Ser Asp Asn Leu Phe Lys Trp Val Gly Thr 
    50                  55                  60                  
Ile His Gly Ala Ala Gly Thr Val Tyr Glu Asp Leu Arg Tyr Lys Leu 
65                  70                  75                  80  
Ser Leu Glu Phe Pro Ser Gly Tyr Pro Tyr Asn Ala Pro Thr Val Lys 
                85                  90                  95      
Phe Leu Thr Pro Cys Tyr His Pro Asn Val Asp Thr Gln Gly Asn Ile 
            100                 105                 110         
Cys Leu Asp Ile Leu Lys Glu Lys Trp Ser Ala Leu Tyr Asp Val Arg 
        115                 120                 125             
Thr Ile Leu Leu Ser Ile Gln Ser Leu Leu Gly Glu Pro Asn Ile Asp 
    130                 135                 140                 
Ser Pro Leu Asn Thr His Ala Ala Glu Leu Trp Lys Asn Pro Thr Ala 
145                 150                 155                 160 
Phe Lys Lys Tyr Leu Gln Glu Thr Tyr Ser Lys Gln Val Thr Ser Gln 
                165                 170                 175     
Glu Pro 
        

<210> 45
<211> 146
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2D1 UBC domain

<400> 45
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met 
145     

<210> 46
<211> 146
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2D2 UBC domain

<400> 46
Ala Leu Lys Arg Ile His Lys Glu Leu Asn Asp Leu Ala Arg Asp Pro 
1               5                   10                  15      
Pro Ala Gln Cys Ser Ala Gly Pro Val Gly Asp Asp Met Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Asn Asp Ser Pro Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Ile His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Val Ala Phe Thr Thr Arg Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala Arg Ile Tyr Lys Thr 
        115                 120                 125             
Asp Arg Glu Lys Tyr Asn Arg Ile Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met 
145     

<210> 47
<211> 146
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2D3 UBC domain

<400> 47
Ala Leu Lys Arg Ile Asn Lys Glu Leu Ser Asp Leu Ala Arg Asp Pro 
1               5                   10                  15      
Pro Ala Gln Cys Ser Ala Gly Pro Val Gly Asp Asp Met Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Asn Asp Ser Pro Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Ile His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Val Ala Phe Thr Thr Arg Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala Arg Ile Tyr Lys Thr 
        115                 120                 125             
Asp Arg Asp Lys Tyr Asn Arg Ile Ser Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met 
145     

<210> 48
<211> 146
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2D4 UBC domain

<400> 48
Ala Leu Lys Arg Ile Gln Lys Glu Leu Thr Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala Gln Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Asn Asp Ser Pro Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Ile His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Val Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala His Thr Tyr Lys Ala 
        115                 120                 125             
Asp Arg Glu Lys Tyr Asn Arg Leu Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met 
145     

<210> 49
<211> 192
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2E1 UBC domain

<400> 49
Ser Asp Asp Asp Ser Arg Ala Ser Thr Ser Ser Ser Ser Ser Ser Ser 
1               5                   10                  15      
Ser Asn Gln Gln Thr Glu Lys Glu Thr Asn Thr Pro Lys Lys Lys Glu 
            20                  25                  30          
Ser Lys Val Ser Met Ser Lys Asn Ser Lys Leu Leu Ser Thr Ser Ala 
        35                  40                  45              
Lys Arg Ile Gln Lys Glu Leu Ala Asp Ile Thr Leu Asp Pro Pro Pro 
    50                  55                  60                  
Asn Cys Ser Ala Gly Pro Lys Gly Asp Asn Ile Tyr Glu Trp Arg Ser 
65                  70                  75                  80  
Thr Ile Leu Gly Pro Pro Gly Ser Val Tyr Glu Gly Gly Val Phe Phe 
                85                  90                  95      
Leu Asp Ile Thr Phe Thr Pro Glu Tyr Pro Phe Lys Pro Pro Lys Val 
            100                 105                 110         
Thr Phe Arg Thr Arg Ile Tyr His Cys Asn Ile Asn Ser Gln Gly Val 
        115                 120                 125             
Ile Cys Leu Asp Ile Leu Lys Asp Asn Trp Ser Pro Ala Leu Thr Ile 
    130                 135                 140                 
Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Thr Asp Cys Asn Pro 
145                 150                 155                 160 
Ala Asp Pro Leu Val Gly Ser Ile Ala Thr Gln Tyr Met Thr Asn Arg 
                165                 170                 175     
Ala Glu His Asp Arg Met Ala Arg Gln Trp Thr Lys Arg Tyr Ala Thr 
            180                 185                 190         



<210> 50
<211> 189
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2E2 UBC domain

<400> 50
Ser Thr Ser Gly Gly Ser Ser Asp Gly Asp Gln Arg Glu Ser Val Gln 
1               5                   10                  15      
Gln Glu Pro Glu Arg Glu Gln Val Gln Pro Lys Lys Lys Glu Gly Lys 
            20                  25                  30          
Ile Ser Ser Lys Thr Ala Ala Lys Leu Ser Thr Ser Ala Lys Arg Ile 
        35                  40                  45              
Gln Lys Glu Leu Ala Glu Ile Thr Leu Asp Pro Pro Pro Asn Cys Ser 
    50                  55                  60                  
Ala Gly Pro Lys Gly Asp Asn Ile Tyr Glu Trp Arg Ser Thr Ile Leu 
65                  70                  75                  80  
Gly Pro Pro Gly Ser Val Tyr Glu Gly Gly Val Phe Phe Leu Asp Ile 
                85                  90                  95      
Thr Phe Ser Pro Asp Tyr Pro Phe Lys Pro Pro Lys Val Thr Phe Arg 
            100                 105                 110         
Thr Arg Ile Tyr His Cys Asn Ile Asn Ser Gln Gly Val Ile Cys Leu 
        115                 120                 125             
Asp Ile Leu Lys Asp Asn Trp Ser Pro Ala Leu Thr Ile Ser Lys Val 
    130                 135                 140                 
Leu Leu Ser Ile Cys Ser Leu Leu Thr Asp Cys Asn Pro Ala Asp Pro 
145                 150                 155                 160 
Leu Val Gly Ser Ile Ala Thr Gln Tyr Met Thr Asn Arg Ala Glu His 
                165                 170                 175     
Asp Arg Met Ala Arg Gln Trp Thr Lys Arg Tyr Ala Thr 
            180                 185                 

<210> 51
<211> 149
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2E3 UBC domain

<400> 51
Leu Ser Thr Ser Ala Lys Arg Ile Gln Lys Glu Leu Ala Glu Ile Thr 
1               5                   10                  15      
Leu Asp Pro Pro Pro Asn Cys Ser Ala Gly Pro Lys Gly Asp Asn Ile 
            20                  25                  30          
Tyr Glu Trp Arg Ser Thr Ile Leu Gly Pro Pro Gly Ser Val Tyr Glu 
        35                  40                  45              
Gly Gly Val Phe Phe Leu Asp Ile Thr Phe Ser Ser Asp Tyr Pro Phe 
    50                  55                  60                  
Lys Pro Pro Lys Val Thr Phe Arg Thr Arg Ile Tyr His Cys Asn Ile 
65                  70                  75                  80  
Asn Ser Gln Gly Val Ile Cys Leu Asp Ile Leu Lys Asp Asn Trp Ser 
                85                  90                  95      
Pro Ala Leu Thr Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu 
            100                 105                 110         
Thr Asp Cys Asn Pro Ala Asp Pro Leu Val Gly Ser Ile Ala Thr Gln 
        115                 120                 125             
Tyr Leu Thr Asn Arg Ala Glu His Asp Arg Ile Ala Arg Gln Trp Thr 
    130                 135                 140                 
Lys Arg Tyr Ala Thr 
145                 

<210> 52
<211> 160
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2F UBC domain

<400> 52
Ser Thr Arg Arg Val Ser Val Arg Asp Lys Leu Leu Val Lys Glu Val 
1               5                   10                  15      
Ala Glu Leu Glu Ala Asn Leu Pro Cys Thr Cys Lys Val His Phe Pro 
            20                  25                  30          
Asp Pro Asn Lys Leu His Cys Phe Gln Leu Thr Val Thr Pro Asp Glu 
        35                  40                  45              
Gly Tyr Tyr Gln Gly Gly Lys Phe Gln Phe Glu Thr Glu Val Pro Asp 
    50                  55                  60                  
Ala Tyr Asn Met Val Pro Pro Lys Val Lys Cys Leu Thr Lys Ile Trp 
65                  70                  75                  80  
His Pro Asn Ile Thr Glu Thr Gly Glu Ile Cys Leu Ser Leu Leu Arg 
                85                  90                  95      
Glu His Ser Ile Asp Gly Thr Gly Trp Ala Pro Thr Arg Thr Leu Lys 
            100                 105                 110         
Asp Val Val Trp Gly Leu Asn Ser Leu Phe Thr Asp Leu Leu Asn Phe 
        115                 120                 125             
Asp Asp Pro Leu Asn Ile Glu Ala Ala Glu His His Leu Arg Asp Lys 
    130                 135                 140                 
Glu Asp Phe Arg Asn Lys Val Asp Asp Tyr Ile Lys Arg Tyr Ala Arg 
145                 150                 155                 160 



<210> 53
<211> 153
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2G1 UBC domain

<400> 53
Leu Leu Leu Arg Arg Gln Leu Ala Glu Leu Asn Lys Asn Pro Val Glu 
1               5                   10                  15      
Gly Phe Ser Ala Gly Leu Ile Asp Asp Asn Asp Leu Tyr Arg Trp Glu 
            20                  25                  30          
Val Leu Ile Ile Gly Pro Pro Asp Thr Leu Tyr Glu Gly Gly Val Phe 
        35                  40                  45              
Lys Ala His Leu Thr Phe Pro Lys Asp Tyr Pro Leu Arg Pro Pro Lys 
    50                  55                  60                  
Met Lys Phe Ile Thr Glu Ile Trp His Pro Asn Val Asp Lys Asn Gly 
65                  70                  75                  80  
Asp Val Cys Ile Ser Ile Leu His Glu Pro Gly Glu Asp Lys Tyr Gly 
                85                  90                  95      
Tyr Glu Lys Pro Glu Glu Arg Trp Leu Pro Ile His Thr Val Glu Thr 
            100                 105                 110         
Ile Met Ile Ser Val Ile Ser Met Leu Ala Asp Pro Asn Gly Asp Ser 
        115                 120                 125             
Pro Ala Asn Val Asp Ala Ala Lys Glu Trp Arg Glu Asp Arg Asn Gly 
    130                 135                 140                 
Glu Phe Lys Arg Lys Val Ala Arg Cys 
145                 150             

<210> 54
<211> 164
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2G2 UBC domain

<400> 54
Ala Gly Thr Ala Leu Lys Arg Leu Met Ala Glu Tyr Lys Gln Leu Thr 
1               5                   10                  15      
Leu Asn Pro Pro Glu Gly Ile Val Ala Gly Pro Met Asn Glu Glu Asn 
            20                  25                  30          
Phe Phe Glu Trp Glu Ala Leu Ile Met Gly Pro Glu Asp Thr Cys Phe 
        35                  40                  45              
Glu Phe Gly Val Phe Pro Ala Ile Leu Ser Phe Pro Leu Asp Tyr Pro 
    50                  55                  60                  
Leu Ser Pro Pro Lys Met Arg Phe Thr Cys Glu Met Phe His Pro Asn 
65                  70                  75                  80  
Ile Tyr Pro Asp Gly Arg Val Cys Ile Ser Ile Leu His Ala Pro Gly 
                85                  90                  95      
Asp Asp Pro Met Gly Tyr Glu Ser Ser Ala Glu Arg Trp Ser Pro Val 
            100                 105                 110         
Gln Ser Val Glu Lys Ile Leu Leu Ser Val Val Ser Met Leu Ala Glu 
        115                 120                 125             
Pro Asn Asp Glu Ser Gly Ala Asn Val Asp Ala Ser Lys Met Trp Arg 
    130                 135                 140                 
Asp Asp Arg Glu Gln Phe Tyr Lys Ile Ala Lys Gln Ile Val Gln Lys 
145                 150                 155                 160 
Ser Leu Gly Leu 
                

<210> 55
<211> 159
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2H UBC domain

<400> 55
Ser Ser Pro Ser Pro Gly Lys Arg Arg Met Asp Thr Asp Val Val Lys 
1               5                   10                  15      
Leu Ile Glu Ser Lys His Glu Val Thr Ile Leu Gly Gly Leu Asn Glu 
            20                  25                  30          
Phe Val Val Lys Phe Tyr Gly Pro Gln Gly Thr Pro Tyr Glu Gly Gly 
        35                  40                  45              
Val Trp Lys Val Arg Val Asp Leu Pro Asp Lys Tyr Pro Phe Lys Ser 
    50                  55                  60                  
Pro Ser Ile Gly Phe Met Asn Lys Ile Phe His Pro Asn Ile Asp Glu 
65                  70                  75                  80  
Ala Ser Gly Thr Val Cys Leu Asp Val Ile Asn Gln Thr Trp Thr Ala 
                85                  90                  95      
Leu Tyr Asp Leu Thr Asn Ile Phe Glu Ser Phe Leu Pro Gln Leu Leu 
            100                 105                 110         
Ala Tyr Pro Asn Pro Ile Asp Pro Leu Asn Gly Asp Ala Ala Ala Met 
        115                 120                 125             
Tyr Leu His Arg Pro Glu Glu Tyr Lys Gln Lys Ile Lys Glu Tyr Ile 
    130                 135                 140                 
Gln Lys Tyr Ala Thr Glu Glu Ala Leu Lys Glu Gln Glu Glu Gly 
145                 150                 155                 

<210> 56
<211> 157
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2I UBC domain

<400> 56
Ser Gly Ile Ala Leu Ser Arg Leu Ala Gln Glu Arg Lys Ala Trp Arg 
1               5                   10                  15      
Lys Asp His Pro Phe Gly Phe Val Ala Val Pro Thr Lys Asn Pro Asp 
            20                  25                  30          
Gly Thr Met Asn Leu Met Asn Trp Glu Cys Ala Ile Pro Gly Lys Lys 
        35                  40                  45              
Gly Thr Pro Trp Glu Gly Gly Leu Phe Lys Leu Arg Met Leu Phe Lys 
    50                  55                  60                  
Asp Asp Tyr Pro Ser Ser Pro Pro Lys Cys Lys Phe Glu Pro Pro Leu 
65                  70                  75                  80  
Phe His Pro Asn Val Tyr Pro Ser Gly Thr Val Cys Leu Ser Ile Leu 
                85                  90                  95      
Glu Glu Asp Lys Asp Trp Arg Pro Ala Ile Thr Ile Lys Gln Ile Leu 
            100                 105                 110         
Leu Gly Ile Gln Glu Leu Leu Asn Glu Pro Asn Ile Gln Asp Pro Ala 
        115                 120                 125             
Gln Ala Glu Ala Tyr Thr Ile Tyr Cys Gln Asn Arg Val Glu Tyr Glu 
    130                 135                 140                 
Lys Arg Val Arg Ala Gln Ala Lys Lys Phe Ala Pro Ser 
145                 150                 155         

<210> 57
<211> 284
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2J1 UBC domain

<400> 57
Glu Thr Arg Tyr Asn Leu Lys Ser Pro Ala Val Lys Arg Leu Met Lys 
1               5                   10                  15      
Glu Ala Ala Glu Leu Lys Asp Pro Thr Asp His Tyr His Ala Gln Pro 
            20                  25                  30          
Leu Glu Asp Asn Leu Phe Glu Trp His Phe Thr Val Arg Gly Pro Pro 
        35                  40                  45              
Asp Ser Asp Phe Asp Gly Gly Val Tyr His Gly Arg Ile Val Leu Pro 
    50                  55                  60                  
Pro Glu Tyr Pro Met Lys Pro Pro Ser Ile Ile Leu Leu Thr Ala Asn 
65                  70                  75                  80  
Gly Arg Phe Glu Val Gly Lys Lys Ile Cys Leu Ser Ile Ser Gly His 
                85                  90                  95      
His Pro Glu Thr Trp Gln Pro Ser Trp Ser Ile Arg Thr Ala Leu Leu 
            100                 105                 110         
Ala Ile Ile Gly Phe Met Pro Thr Lys Gly Glu Gly Ala Ile Gly Ser 
        115                 120                 125             
Leu Asp Tyr Thr Pro Glu Glu Arg Arg Ala Leu Ala Lys Lys Ser Gln 
    130                 135                 140                 
Asp Phe Cys Cys Glu Gly Cys Gly Ser Ala Met Lys Asp Val Leu Leu 
145                 150                 155                 160 
Pro Leu Lys Ser Gly Ser Asp Ser Ser Gln Ala Asp Gln Glu Ala Lys 
                165                 170                 175     
Glu Leu Ala Arg Gln Ile Ser Phe Lys Ala Glu Val Asn Ser Ser Gly 
            180                 185                 190         
Lys Thr Ile Ser Glu Ser Asp Leu Asn His Ser Phe Ser Leu Thr Asp 
        195                 200                 205             
Leu Gln Asp Asp Ile Pro Thr Thr Phe Gln Gly Ala Thr Ala Ser Thr 
    210                 215                 220                 
Ser Tyr Gly Leu Gln Asn Ser Ser Ala Ala Ser Phe His Gln Pro Thr 
225                 230                 235                 240 
Gln Pro Val Ala Lys Asn Thr Ser Met Ser Pro Arg Gln Arg Arg Ala 
                245                 250                 255     
Gln Gln Gln Ser Gln Arg Arg Leu Ser Thr Ser Pro Asp Val Ile Gln 
            260                 265                 270         
Gly His Gln Pro Arg Asp Asn His Thr Asp His Gly 
        275                 280                 

<210> 58
<211> 184
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2J2 UBC domain

<400> 58
Ser Ser Thr Ser Ser Lys Arg Ala Pro Thr Thr Ala Thr Gln Arg Leu 
1               5                   10                  15      
Lys Gln Asp Tyr Leu Arg Ile Lys Lys Asp Pro Val Pro Tyr Ile Cys 
            20                  25                  30          
Ala Glu Pro Leu Pro Ser Asn Ile Leu Glu Trp His Tyr Val Val Arg 
        35                  40                  45              
Gly Pro Glu Met Thr Pro Tyr Glu Gly Gly Tyr Tyr His Gly Lys Leu 
    50                  55                  60                  
Ile Phe Pro Arg Glu Phe Pro Phe Lys Pro Pro Ser Ile Tyr Met Ile 
65                  70                  75                  80  
Thr Pro Asn Gly Arg Phe Lys Cys Asn Thr Arg Leu Cys Leu Ser Ile 
                85                  90                  95      
Thr Asp Phe His Pro Asp Thr Trp Asn Pro Ala Trp Ser Val Ser Thr 
            100                 105                 110         
Ile Leu Thr Gly Leu Leu Ser Phe Met Val Glu Lys Gly Pro Thr Leu 
        115                 120                 125             
Gly Ser Ile Glu Thr Ser Asp Phe Thr Lys Arg Gln Leu Ala Val Gln 
    130                 135                 140                 
Ser Leu Ala Phe Asn Leu Lys Asp Lys Val Phe Cys Glu Leu Phe Pro 
145                 150                 155                 160 
Glu Val Val Glu Glu Ile Lys Gln Lys Gln Lys Ala Gln Asp Glu Leu 
                165                 170                 175     
Ser Ser Arg Pro Gln Thr Leu Pro 
            180                 

<210> 59
<211> 199
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2K UBC domain

<400> 59
Ala Asn Ile Ala Val Gln Arg Ile Lys Arg Glu Phe Lys Glu Val Leu 
1               5                   10                  15      
Lys Ser Glu Glu Thr Ser Lys Asn Gln Ile Lys Val Asp Leu Val Asp 
            20                  25                  30          
Glu Asn Phe Thr Glu Leu Arg Gly Glu Ile Ala Gly Pro Pro Asp Thr 
        35                  40                  45              
Pro Tyr Glu Gly Gly Arg Tyr Gln Leu Glu Ile Lys Ile Pro Glu Thr 
    50                  55                  60                  
Tyr Pro Phe Asn Pro Pro Lys Val Arg Phe Ile Thr Lys Ile Trp His 
65                  70                  75                  80  
Pro Asn Ile Ser Ser Val Thr Gly Ala Ile Cys Leu Asp Ile Leu Lys 
                85                  90                  95      
Asp Gln Trp Ala Ala Ala Met Thr Leu Arg Thr Val Leu Leu Ser Leu 
            100                 105                 110         
Gln Ala Leu Leu Ala Ala Ala Glu Pro Asp Asp Pro Gln Asp Ala Val 
        115                 120                 125             
Val Ala Asn Gln Tyr Lys Gln Asn Pro Glu Met Phe Lys Gln Thr Ala 
    130                 135                 140                 
Arg Leu Trp Ala His Val Tyr Ala Gly Ala Pro Val Ser Ser Pro Glu 
145                 150                 155                 160 
Tyr Thr Lys Lys Ile Glu Asn Leu Cys Ala Met Gly Phe Asp Arg Asn 
                165                 170                 175     
Ala Val Ile Val Ala Leu Ser Ser Lys Ser Trp Asp Val Glu Thr Ala 
            180                 185                 190         
Thr Glu Leu Leu Leu Ser Asn 
        195                 

<210> 60
<211> 153
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2L3 UBC domain

<400> 60
Ala Ala Ser Arg Arg Leu Met Lys Glu Leu Glu Glu Ile Arg Lys Cys 
1               5                   10                  15      
Gly Met Lys Asn Phe Arg Asn Ile Gln Val Asp Glu Ala Asn Leu Leu 
            20                  25                  30          
Thr Trp Gln Gly Leu Ile Val Pro Asp Asn Pro Pro Tyr Asp Lys Gly 
        35                  40                  45              
Ala Phe Arg Ile Glu Ile Asn Phe Pro Ala Glu Tyr Pro Phe Lys Pro 
    50                  55                  60                  
Pro Lys Ile Thr Phe Lys Thr Lys Ile Tyr His Pro Asn Ile Asp Glu 
65                  70                  75                  80  
Lys Gly Gln Val Cys Leu Pro Val Ile Ser Ala Glu Asn Trp Lys Pro 
                85                  90                  95      
Ala Thr Lys Thr Asp Gln Val Ile Gln Ser Leu Ile Ala Leu Val Asn 
            100                 105                 110         
Asp Pro Gln Pro Glu His Pro Leu Arg Ala Asp Leu Ala Glu Glu Tyr 
        115                 120                 125             
Ser Lys Asp Arg Lys Lys Phe Cys Lys Asn Ala Glu Glu Phe Thr Lys 
    130                 135                 140                 
Lys Tyr Gly Glu Lys Arg Pro Val Asp 
145                 150             

<210> 61
<211> 152
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2L6 UBC domain

<400> 61
Met Ala Ser Met Arg Val Val Lys Glu Leu Glu Asp Leu Gln Lys Lys 
1               5                   10                  15      
Pro Pro Pro Tyr Leu Arg Asn Leu Ser Ser Asp Asp Ala Asn Val Leu 
            20                  25                  30          
Val Trp His Ala Leu Leu Leu Pro Asp Gln Pro Pro Tyr His Leu Lys 
        35                  40                  45              
Ala Phe Asn Leu Arg Ile Ser Phe Pro Pro Glu Tyr Pro Phe Lys Pro 
    50                  55                  60                  
Pro Met Ile Lys Phe Thr Thr Lys Ile Tyr His Pro Asn Val Asp Glu 
65                  70                  75                  80  
Asn Gly Gln Ile Cys Leu Pro Ile Ile Ser Ser Glu Asn Trp Lys Pro 
                85                  90                  95      
Cys Thr Lys Thr Cys Gln Val Leu Glu Ala Leu Asn Val Leu Val Asn 
            100                 105                 110         
Arg Pro Asn Ile Arg Glu Pro Leu Arg Met Asp Leu Ala Asp Leu Leu 
        115                 120                 125             
Thr Gln Asn Pro Glu Leu Phe Arg Lys Asn Ala Glu Glu Phe Thr Leu 
    130                 135                 140                 
Arg Phe Gly Val Asp Arg Pro Ser 
145                 150         

<210> 62
<211> 157
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2M UBC domain

<400> 62
Ala Ser Ala Ala Gln Leu Arg Ile Gln Lys Asp Ile Asn Glu Leu Asn 
1               5                   10                  15      
Leu Pro Lys Thr Cys Asp Ile Ser Phe Ser Asp Pro Asp Asp Leu Leu 
            20                  25                  30          
Asn Phe Lys Leu Val Ile Cys Pro Asp Glu Gly Phe Tyr Lys Ser Gly 
        35                  40                  45              
Lys Phe Val Phe Ser Phe Lys Val Gly Gln Gly Tyr Pro His Asp Pro 
    50                  55                  60                  
Pro Lys Val Lys Cys Glu Thr Met Val Tyr His Pro Asn Ile Asp Leu 
65                  70                  75                  80  
Glu Gly Asn Val Cys Leu Asn Ile Leu Arg Glu Asp Trp Lys Pro Val 
                85                  90                  95      
Leu Thr Ile Asn Ser Ile Ile Tyr Gly Leu Gln Tyr Leu Phe Leu Glu 
            100                 105                 110         
Pro Asn Pro Glu Asp Pro Leu Asn Lys Glu Ala Ala Glu Val Leu Gln 
        115                 120                 125             
Asn Asn Arg Arg Leu Phe Glu Gln Asn Val Gln Arg Ser Met Arg Gly 
    130                 135                 140                 
Gly Tyr Ile Gly Ser Thr Tyr Phe Glu Arg Cys Leu Lys 
145                 150                 155         

<210> 63
<211> 151
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2N UBC domain

<400> 63
Ala Gly Leu Pro Arg Arg Ile Ile Lys Glu Thr Gln Arg Leu Leu Ala 
1               5                   10                  15      
Glu Pro Val Pro Gly Ile Lys Ala Glu Pro Asp Glu Ser Asn Ala Arg 
            20                  25                  30          
Tyr Phe His Val Val Ile Ala Gly Pro Gln Asp Ser Pro Phe Glu Gly 
        35                  40                  45              
Gly Thr Phe Lys Leu Glu Leu Phe Leu Pro Glu Glu Tyr Pro Met Ala 
    50                  55                  60                  
Ala Pro Lys Val Arg Phe Met Thr Lys Ile Tyr His Pro Asn Val Asp 
65                  70                  75                  80  
Lys Leu Gly Arg Ile Cys Leu Asp Ile Leu Lys Asp Lys Trp Ser Pro 
                85                  90                  95      
Ala Leu Gln Ile Arg Thr Val Leu Leu Ser Ile Gln Ala Leu Leu Ser 
            100                 105                 110         
Ala Pro Asn Pro Asp Asp Pro Leu Ala Asn Asp Val Ala Glu Gln Trp 
        115                 120                 125             
Lys Thr Asn Glu Ala Gln Ala Ile Glu Thr Ala Arg Ala Trp Thr Arg 
    130                 135                 140                 
Leu Tyr Ala Met Asn Asn Ile 
145                 150     

<210> 64
<211> 152
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2NL UBC domain

<400> 64
Ala Glu Leu Pro His Arg Ile Ile Lys Glu Thr Gln Arg Leu Leu Ala 
1               5                   10                  15      
Glu Pro Val Pro Gly Ile Lys Ala Glu Pro Asp Glu Ser Asn Ala Arg 
            20                  25                  30          
Tyr Phe His Val Val Ile Ala Gly Glu Ser Lys Asp Ser Pro Phe Glu 
        35                  40                  45              
Gly Gly Thr Phe Lys Arg Glu Leu Leu Leu Ala Glu Glu Tyr Pro Met 
    50                  55                  60                  
Ala Ala Pro Lys Val Arg Phe Met Thr Lys Ile Tyr His Pro Asn Val 
65                  70                  75                  80  
Asp Lys Leu Glu Arg Ile Ser Leu Asp Ile Leu Lys Asp Lys Trp Ser 
                85                  90                  95      
Pro Ala Leu Gln Ile Arg Thr Val Leu Leu Ser Ile Gln Ala Leu Leu 
            100                 105                 110         
Asn Ala Pro Asn Pro Asp Asp Pro Leu Ala Asn Asp Val Val Glu Gln 
        115                 120                 125             
Trp Lys Thr Asn Glu Ala Gln Ala Ile Glu Thr Ala Arg Ala Trp Thr 
    130                 135                 140                 
Arg Leu Tyr Ala Met Asn Ser Ile 
145                 150         

<210> 65
<211> 138
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2O UBC domain

<400> 65
Ser Asn His Ser Phe Lys Lys Ile Glu Phe Gln Pro Pro Glu Ala Lys 
1               5                   10                  15      
Lys Phe Phe Ser Thr Val Arg Lys Glu Met Ala Leu Leu Ala Thr Ser 
            20                  25                  30          
Leu Pro Glu Gly Ile Met Val Lys Thr Phe Glu Asp Arg Met Asp Leu 
        35                  40                  45              
Phe Ser Ala Leu Ile Lys Gly Pro Thr Arg Thr Pro Tyr Glu Asp Gly 
    50                  55                  60                  
Leu Tyr Leu Phe Asp Ile Gln Leu Pro Asn Ile Tyr Pro Ala Val Pro 
65                  70                  75                  80  
Pro His Phe Cys Tyr Leu Ser Gln Cys Ser Gly Arg Leu Asn Pro Asn 
                85                  90                  95      
Leu Tyr Asp Asn Gly Lys Val Cys Val Ser Leu Leu Gly Thr Trp Ile 
            100                 105                 110         
Gly Lys Gly Thr Glu Arg Trp Thr Ser Lys Ser Ser Leu Leu Gln Val 
        115                 120                 125             
Leu Ile Ser Ile Gln Gly Leu Ile Leu Val 
    130                 135             

<210> 66
<211> 168
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2Q1 UBC domain

<400> 66
Ser Gly Ser Val Gln Ala Thr Asp Arg Leu Met Lys Glu Leu Arg Asp 
1               5                   10                  15      
Ile Tyr Arg Ser Gln Ser Phe Lys Gly Gly Asn Tyr Ala Val Glu Leu 
            20                  25                  30          
Val Asn Asp Ser Leu Tyr Asp Trp Asn Val Lys Leu Leu Lys Val Asp 
        35                  40                  45              
Gln Asp Ser Ala Leu His Asn Asp Leu Gln Ile Leu Lys Glu Lys Glu 
    50                  55                  60                  
Gly Ala Asp Phe Ile Leu Leu Asn Phe Ser Phe Lys Asp Asn Phe Pro 
65                  70                  75                  80  
Phe Asp Pro Pro Phe Val Arg Val Val Ser Pro Val Leu Ser Gly Gly 
                85                  90                  95      
Tyr Val Leu Gly Gly Gly Ala Ile Cys Met Glu Leu Leu Thr Lys Gln 
            100                 105                 110         
Gly Trp Ser Ser Ala Tyr Ser Ile Glu Ser Val Ile Met Gln Ile Ser 
        115                 120                 125             
Ala Thr Leu Val Lys Gly Lys Ala Arg Val Gln Phe Gly Ala Asn Lys 
    130                 135                 140                 
Ser Gln Tyr Ser Leu Thr Arg Ala Gln Gln Ser Tyr Lys Ser Leu Val 
145                 150                 155                 160 
Gln Ile His Glu Lys Asn Gly Trp 
                165             

<210> 67
<211> 167
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2Q2 UBC domain

<400> 67
Gly Ala Val Ser Gly Ser Val Gln Ala Ser Asp Arg Leu Met Lys Glu 
1               5                   10                  15      
Leu Arg Asp Ile Tyr Arg Ser Gln Ser Tyr Lys Thr Gly Ile Tyr Ser 
            20                  25                  30          
Val Glu Leu Ile Asn Asp Ser Leu Tyr Asp Trp His Val Lys Leu Gln 
        35                  40                  45              
Lys Val Asp Pro Asp Ser Pro Leu His Ser Asp Leu Gln Ile Leu Lys 
    50                  55                  60                  
Glu Lys Glu Gly Ile Glu Tyr Ile Leu Leu Asn Phe Ser Phe Lys Asp 
65                  70                  75                  80  
Asn Phe Pro Phe Asp Pro Pro Phe Val Arg Val Val Leu Pro Val Leu 
                85                  90                  95      
Ser Gly Gly Tyr Val Leu Gly Gly Gly Ala Leu Cys Met Glu Leu Leu 
            100                 105                 110         
Thr Lys Gln Gly Trp Ser Ser Ala Tyr Ser Ile Glu Ser Val Ile Met 
        115                 120                 125             
Gln Ile Asn Ala Thr Leu Val Lys Gly Lys Ala Arg Val Gln Phe Gly 
    130                 135                 140                 
Ala Asn Lys Asn Gln Tyr Asn Leu Ala Arg Ala Gln Gln Ser Tyr Asn 
145                 150                 155                 160 
Ser Ile Val Gln Ile His Glu 
                165         

<210> 68
<211> 160
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2QL UBC domain

<400> 68
Lys Glu Leu Gln Asp Ile Ala Arg Leu Ser Asp Arg Phe Ile Ser Val 
1               5                   10                  15      
Glu Leu Val Asp Glu Ser Leu Phe Asp Trp Asn Val Lys Leu His Gln 
            20                  25                  30          
Val Asp Lys Asp Ser Val Leu Trp Gln Asp Met Lys Glu Thr Asn Thr 
        35                  40                  45              
Glu Phe Ile Leu Leu Asn Leu Thr Phe Pro Asp Asn Phe Pro Phe Ser 
    50                  55                  60                  
Pro Pro Phe Met Arg Val Leu Ser Pro Arg Leu Glu Asn Gly Tyr Val 
65                  70                  75                  80  
Leu Asp Gly Gly Ala Ile Cys Met Glu Leu Leu Thr Pro Arg Gly Trp 
                85                  90                  95      
Ser Ser Ala Tyr Thr Val Glu Ala Val Met Arg Gln Phe Ala Ala Ser 
            100                 105                 110         
Leu Val Lys Gly Gln Gly Arg Ile Cys Arg Lys Ala Gly Lys Ser Lys 
        115                 120                 125             
Lys Ser Phe Ser Arg Lys Glu Ala Glu Ala Thr Phe Lys Ser Leu Val 
    130                 135                 140                 
Lys Thr His Glu Lys Tyr Gly Trp Val Thr Pro Pro Val Ser Asp Gly 
145                 150                 155                 160 



<210> 69
<211> 178
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2R1 UBC domain

<400> 69
Pro Ser Ser Gln Lys Ala Leu Leu Leu Glu Leu Lys Gly Leu Gln Glu 
1               5                   10                  15      
Glu Pro Val Glu Gly Phe Arg Val Thr Leu Val Asp Glu Gly Asp Leu 
            20                  25                  30          
Tyr Asn Trp Glu Val Ala Ile Phe Gly Pro Pro Asn Thr Tyr Tyr Glu 
        35                  40                  45              
Gly Gly Tyr Phe Lys Ala Arg Leu Lys Phe Pro Ile Asp Tyr Pro Tyr 
    50                  55                  60                  
Ser Pro Pro Ala Phe Arg Phe Leu Thr Lys Met Trp His Pro Asn Ile 
65                  70                  75                  80  
Tyr Glu Thr Gly Asp Val Cys Ile Ser Ile Leu His Pro Pro Val Asp 
                85                  90                  95      
Asp Pro Gln Ser Gly Glu Leu Pro Ser Glu Arg Trp Asn Pro Thr Gln 
            100                 105                 110         
Asn Val Arg Thr Ile Leu Leu Ser Val Ile Ser Leu Leu Asn Glu Pro 
        115                 120                 125             
Asn Thr Phe Ser Pro Ala Asn Val Asp Ala Ser Val Met Tyr Arg Lys 
    130                 135                 140                 
Trp Lys Glu Ser Lys Gly Lys Asp Arg Glu Tyr Thr Asp Ile Ile Arg 
145                 150                 155                 160 
Lys Gln Val Leu Gly Thr Lys Val Asp Ala Glu Arg Asp Gly Val Lys 
                165                 170                 175     
Val Pro 
        

<210> 70
<211> 178
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2R2 UBC domain

<400> 70
Thr Ser Ser Gln Lys Ala Leu Met Leu Glu Leu Lys Ser Leu Gln Glu 
1               5                   10                  15      
Glu Pro Val Glu Gly Phe Arg Ile Thr Leu Val Asp Glu Ser Asp Leu 
            20                  25                  30          
Tyr Asn Trp Glu Val Ala Ile Phe Gly Pro Pro Asn Thr Leu Tyr Glu 
        35                  40                  45              
Gly Gly Tyr Phe Lys Ala His Ile Lys Phe Pro Ile Asp Tyr Pro Tyr 
    50                  55                  60                  
Ser Pro Pro Thr Phe Arg Phe Leu Thr Lys Met Trp His Pro Asn Ile 
65                  70                  75                  80  
Tyr Glu Asn Gly Asp Val Cys Ile Ser Ile Leu His Pro Pro Val Asp 
                85                  90                  95      
Asp Pro Gln Ser Gly Glu Leu Pro Ser Glu Arg Trp Asn Pro Thr Gln 
            100                 105                 110         
Asn Val Arg Thr Ile Leu Leu Ser Val Ile Ser Leu Leu Asn Glu Pro 
        115                 120                 125             
Asn Thr Phe Ser Pro Ala Asn Val Asp Ala Ser Val Met Phe Arg Lys 
    130                 135                 140                 
Trp Arg Asp Ser Lys Gly Lys Asp Lys Glu Tyr Ala Glu Ile Ile Arg 
145                 150                 155                 160 
Lys Gln Val Ser Ala Thr Lys Ala Glu Ala Glu Lys Asp Gly Val Lys 
                165                 170                 175     
Val Pro 
        

<210> 71
<211> 155
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2S UBC domain

<400> 71
Asn Ser Asn Val Glu Asn Leu Pro Pro His Ile Ile Arg Leu Val Tyr 
1               5                   10                  15      
Lys Glu Val Thr Thr Leu Thr Ala Asp Pro Pro Asp Gly Ile Lys Val 
            20                  25                  30          
Phe Pro Asn Glu Glu Asp Leu Thr Asp Leu Gln Val Thr Ile Glu Gly 
        35                  40                  45              
Pro Glu Gly Thr Pro Tyr Ala Gly Gly Leu Phe Arg Met Lys Leu Leu 
    50                  55                  60                  
Leu Gly Lys Asp Phe Pro Ala Ser Pro Pro Lys Gly Tyr Phe Leu Thr 
65                  70                  75                  80  
Lys Ile Phe His Pro Asn Val Gly Ala Asn Gly Glu Ile Cys Val Asn 
                85                  90                  95      
Val Leu Lys Arg Asp Trp Thr Ala Glu Leu Gly Ile Arg His Val Leu 
            100                 105                 110         
Leu Thr Ile Lys Cys Leu Leu Ile His Pro Asn Pro Glu Ser Ala Leu 
        115                 120                 125             
Asn Glu Glu Ala Gly Arg Leu Leu Leu Glu Asn Tyr Glu Glu Tyr Ala 
    130                 135                 140                 
Ala Arg Ala Arg Leu Leu Thr Glu Ile His Gly 
145                 150                 155 

<210> 72
<211> 166
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2T UBC domain

<400> 72
Gln Arg Ala Ser Arg Leu Lys Arg Glu Leu His Met Leu Ala Thr Glu 
1               5                   10                  15      
Pro Pro Pro Gly Ile Thr Cys Trp Gln Asp Lys Asp Gln Met Asp Asp 
            20                  25                  30          
Leu Arg Ala Gln Ile Leu Gly Gly Ala Asn Thr Pro Tyr Glu Lys Gly 
        35                  40                  45              
Val Phe Lys Leu Glu Val Ile Ile Pro Glu Arg Tyr Pro Phe Glu Pro 
    50                  55                  60                  
Pro Gln Ile Arg Phe Leu Thr Pro Ile Tyr His Pro Asn Ile Asp Ser 
65                  70                  75                  80  
Ala Gly Arg Ile Cys Leu Asp Val Leu Lys Leu Pro Pro Lys Gly Ala 
                85                  90                  95      
Trp Arg Pro Ser Leu Asn Ile Ala Thr Val Leu Thr Ser Ile Gln Leu 
            100                 105                 110         
Leu Met Ser Glu Pro Asn Pro Asp Asp Pro Leu Met Ala Asp Ile Ser 
        115                 120                 125             
Ser Glu Phe Lys Tyr Asn Lys Pro Ala Phe Leu Lys Asn Ala Arg Gln 
    130                 135                 140                 
Trp Thr Glu Lys His Ala Arg Gln Lys Gln Lys Ala Asp Glu Glu Glu 
145                 150                 155                 160 
Met Leu Asp Asn Leu Pro 
                165     

<210> 73
<211> 149
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2U UBC domain

<400> 73
His Gly Arg Ala Tyr Leu Leu Leu His Arg Asp Phe Cys Asp Leu Lys 
1               5                   10                  15      
Glu Asn Asn Tyr Lys Gly Ile Thr Ala Lys Pro Val Ser Glu Asp Met 
            20                  25                  30          
Met Glu Trp Glu Val Glu Ile Glu Gly Leu Gln Asn Ser Val Trp Gln 
        35                  40                  45              
Gly Leu Val Phe Gln Leu Thr Ile His Phe Thr Ser Glu Tyr Asn Tyr 
    50                  55                  60                  
Ala Pro Pro Val Val Lys Phe Ile Thr Ile Pro Phe His Pro Asn Val 
65                  70                  75                  80  
Asp Pro His Thr Gly Gln Pro Cys Ile Asp Phe Leu Asp Asn Pro Glu 
                85                  90                  95      
Lys Trp Asn Thr Asn Tyr Thr Leu Ser Ser Ile Leu Leu Ala Leu Gln 
            100                 105                 110         
Val Met Leu Ser Asn Pro Val Leu Glu Asn Pro Val Asn Leu Glu Ala 
        115                 120                 125             
Ala Arg Ile Leu Val Lys Asp Glu Ser Leu Tyr Arg Thr Ile Leu Arg 
    130                 135                 140                 
Leu Phe Asn Arg Pro 
145                 

<210> 74
<211> 140
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2V1 UBC domain

<400> 74
Gly Val Lys Val Pro Arg Asn Phe Arg Leu Leu Glu Glu Leu Glu Glu 
1               5                   10                  15      
Gly Gln Lys Gly Val Gly Asp Gly Thr Val Ser Trp Gly Leu Glu Asp 
            20                  25                  30          
Asp Glu Asp Met Thr Leu Thr Arg Trp Thr Gly Met Ile Ile Gly Pro 
        35                  40                  45              
Pro Arg Thr Ile Tyr Glu Asn Arg Ile Tyr Ser Leu Lys Ile Glu Cys 
    50                  55                  60                  
Gly Pro Lys Tyr Pro Glu Ala Pro Pro Phe Val Arg Phe Val Thr Lys 
65                  70                  75                  80  
Ile Asn Met Asn Gly Val Asn Ser Ser Asn Gly Val Val Asp Pro Arg 
                85                  90                  95      
Ala Ile Ser Val Leu Ala Lys Trp Gln Asn Ser Tyr Ser Ile Lys Val 
            100                 105                 110         
Val Leu Gln Glu Leu Arg Arg Leu Met Met Ser Lys Glu Asn Met Lys 
        115                 120                 125             
Leu Pro Gln Pro Pro Glu Gly Gln Cys Tyr Ser Asn 
    130                 135                 140 

<210> 75
<211> 144
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2V2 UBC domain

<400> 75
Ala Val Ser Thr Gly Val Lys Val Pro Arg Asn Phe Arg Leu Leu Glu 
1               5                   10                  15      
Glu Leu Glu Glu Gly Gln Lys Gly Val Gly Asp Gly Thr Val Ser Trp 
            20                  25                  30          
Gly Leu Glu Asp Asp Glu Asp Met Thr Leu Thr Arg Trp Thr Gly Met 
        35                  40                  45              
Ile Ile Gly Pro Pro Arg Thr Asn Tyr Glu Asn Arg Ile Tyr Ser Leu 
    50                  55                  60                  
Lys Val Glu Cys Gly Pro Lys Tyr Pro Glu Ala Pro Pro Ser Val Arg 
65                  70                  75                  80  
Phe Val Thr Lys Ile Asn Met Asn Gly Ile Asn Asn Ser Ser Gly Met 
                85                  90                  95      
Val Asp Ala Arg Ser Ile Pro Val Leu Ala Lys Trp Gln Asn Ser Tyr 
            100                 105                 110         
Ser Ile Lys Val Val Leu Gln Glu Leu Arg Arg Leu Met Met Ser Lys 
        115                 120                 125             
Glu Asn Met Lys Leu Pro Gln Pro Pro Glu Gly Gln Thr Tyr Asn Asn 
    130                 135                 140                 



<210> 76
<211> 117
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2W UBC domain

<400> 76
Met Ala Ser Met Gln Lys Arg Leu Gln Lys Glu Leu Leu Ala Leu Gln 
1               5                   10                  15      
Asn Asp Pro Pro Pro Gly Met Thr Leu Asn Glu Lys Ser Val Gln Asn 
            20                  25                  30          
Ser Ile Thr Gln Trp Ile Val Asp Met Glu Gly Ala Pro Gly Thr Leu 
        35                  40                  45              
Tyr Glu Gly Glu Lys Phe Gln Leu Leu Phe Lys Phe Ser Ser Arg Tyr 
    50                  55                  60                  
Pro Phe Asp Ser Pro Gln Val Met Phe Thr Gly Glu Asn Ile Pro Val 
65                  70                  75                  80  
His Pro His Val Tyr Ser Asn Gly His Ile Cys Leu Ser Ile Leu Thr 
                85                  90                  95      
Glu Asp Trp Ser Pro Ala Leu Ser Val Gln Ser Val Cys Leu Ser Ile 
            100                 105                 110         
Ile Ser Met Leu Ser 
        115         

<210> 77
<211> 145
<212> PRT
<213> Homo sapiens


<220> 
<223> UBE2Z UBC domain

<400> 77
Met Ser Ile Tyr Lys Glu Pro Pro Pro Gly Met Phe Val Val Pro Asp 
1               5                   10                  15      
Thr Val Asp Met Thr Lys Ile His Ala Leu Ile Thr Gly Pro Phe Asp 
            20                  25                  30          
Thr Pro Tyr Glu Gly Gly Phe Phe Leu Phe Val Phe Arg Cys Pro Pro 
        35                  40                  45              
Asp Tyr Pro Ile His Pro Pro Arg Val Lys Leu Met Thr Thr Gly Asn 
    50                  55                  60                  
Asn Thr Val Arg Phe Asn Pro Asn Phe Tyr Arg Asn Gly Lys Val Cys 
65                  70                  75                  80  
Leu Ser Ile Leu Gly Thr Trp Thr Gly Pro Ala Trp Ser Pro Ala Gln 
                85                  90                  95      
Ser Ile Ser Ser Val Leu Ile Ser Ile Gln Ser Leu Met Thr Glu Asn 
            100                 105                 110         
Pro Tyr His Asn Glu Pro Gly Phe Glu Gln Glu Arg His Pro Gly Asp 
        115                 120                 125             
Ser Lys Asn Tyr Asn Glu Cys Ile Arg His Glu Thr Ile Arg Val Ala 
    130                 135                 140                 
Val 
145 

<210> 78
<211> 182
<212> PRT
<213> Homo sapiens


<220> 
<223> UEVLD UBC domain

<400> 78
Met Glu Phe Asp Cys Glu Gly Leu Arg Arg Leu Leu Gly Lys Tyr Lys 
1               5                   10                  15      
Phe Arg Asp Leu Thr Val Glu Glu Leu Arg Asn Val Asn Val Phe Phe 
            20                  25                  30          
Pro His Phe Lys Tyr Ser Met Asp Thr Tyr Val Phe Lys Asp Ser Ser 
        35                  40                  45              
Gln Lys Asp Leu Leu Asn Phe Thr Gly Thr Ile Pro Val Met Tyr Gln 
    50                  55                  60                  
Gly Asn Thr Tyr Asn Ile Pro Ile Arg Phe Trp Ile Leu Asp Ser His 
65                  70                  75                  80  
Pro Phe Ala Pro Pro Ile Cys Phe Leu Lys Pro Thr Ala Asn Met Gly 
                85                  90                  95      
Ile Leu Val Gly Lys His Val Asp Ala Gln Gly Arg Ile Tyr Leu Pro 
            100                 105                 110         
Tyr Leu Gln Asn Trp Ser His Pro Lys Ser Val Ile Val Gly Leu Ile 
        115                 120                 125             
Lys Glu Met Ile Ala Lys Phe Gln Glu Glu Leu Pro Met Tyr Ser Leu 
    130                 135                 140                 
Ser Ser Ser Asp Glu Ala Arg Gln Val Asp Leu Leu Ala Tyr Ile Ala 
145                 150                 155                 160 
Lys Ile Thr Glu Gly Val Ser Asp Thr Asn Ser Lys Ser Trp Ala Asn 
                165                 170                 175     
His Glu Asn Lys Thr Val 
            180         

<210> 79
<211> 203
<212> PRT
<213> Homo sapiens


<220> 
<223> BIRC6 UBC domain

<400> 79
Ala Asn Gln Glu Lys Lys Leu Gly Glu Tyr Ser Lys Lys Ala Ala Met 
1               5                   10                  15      
Lys Pro Lys Pro Leu Ser Val Leu Lys Ser Leu Glu Glu Lys Tyr Val 
            20                  25                  30          
Ala Val Met Lys Lys Leu Gln Phe Asp Thr Phe Glu Met Val Ser Glu 
        35                  40                  45              
Asp Glu Asp Gly Lys Leu Gly Phe Lys Val Asn Tyr His Tyr Met Ser 
    50                  55                  60                  
Gln Val Lys Asn Ala Asn Asp Ala Asn Ser Ala Ala Arg Ala Arg Arg 
65                  70                  75                  80  
Leu Ala Gln Glu Ala Val Thr Leu Ser Thr Ser Leu Pro Leu Ser Ser 
                85                  90                  95      
Ser Ser Ser Val Phe Val Arg Cys Asp Glu Glu Arg Leu Asp Ile Met 
            100                 105                 110         
Lys Val Leu Ile Thr Gly Pro Ala Asp Thr Pro Tyr Ala Asn Gly Cys 
        115                 120                 125             
Phe Glu Phe Asp Val Tyr Phe Pro Gln Asp Tyr Pro Ser Ser Pro Pro 
    130                 135                 140                 
Leu Val Asn Leu Glu Thr Thr Gly Gly His Ser Val Arg Phe Asn Pro 
145                 150                 155                 160 
Asn Leu Tyr Asn Asp Gly Lys Val Cys Leu Ser Ile Leu Asn Thr Trp 
                165                 170                 175     
His Gly Arg Pro Glu Glu Lys Trp Asn Pro Gln Thr Ser Ser Phe Leu 
            180                 185                 190         
Gln Val Leu Val Ser Val Gln Ser Leu Ile Leu 
        195                 200             

<210> 80
<211> 202
<212> PRT
<213> Homo sapiens


<220> 
<223> FTS UBC domain

<400> 80
Pro Pro Arg Thr Ala Pro Lys Lys Gln Leu Pro Ser Ile Pro Lys Asn 
1               5                   10                  15      
Ala Leu Pro Ile Thr Lys Pro Thr Ser Pro Ala Pro Ala Ala Gln Ser 
            20                  25                  30          
Thr Asn Gly Thr His Ala Ser Tyr Gly Pro Phe Tyr Leu Glu Tyr Ser 
        35                  40                  45              
Leu Leu Ala Glu Phe Thr Leu Val Val Lys Gln Lys Leu Pro Gly Val 
    50                  55                  60                  
Tyr Val Gln Pro Ser Tyr Arg Ser Ala Leu Met Trp Phe Gly Val Ile 
65                  70                  75                  80  
Phe Ile Arg His Gly Leu Tyr Gln Asp Gly Val Phe Lys Phe Thr Val 
                85                  90                  95      
Tyr Ile Pro Asp Asn Tyr Pro Asp Gly Asp Cys Pro Arg Leu Val Phe 
            100                 105                 110         
Asp Ile Pro Val Phe His Pro Leu Val Asp Pro Thr Ser Gly Glu Leu 
        115                 120                 125             
Asp Val Lys Arg Ala Phe Ala Lys Trp Arg Arg Asn His Asn His Ile 
    130                 135                 140                 
Trp Gln Val Leu Met Tyr Ala Arg Arg Val Phe Tyr Lys Ile Asp Thr 
145                 150                 155                 160 
Ala Ser Pro Leu Asn Pro Glu Ala Ala Val Leu Tyr Glu Lys Asp Ile 
                165                 170                 175     
Gln Leu Phe Lys Ser Lys Val Val Asp Ser Val Lys Val Cys Thr Ala 
            180                 185                 190         
Arg Leu Phe Asp Gln Pro Lys Ile Glu Asp 
        195                 200         

<210> 81
<211> 144
<212> PRT
<213> Homo sapiens


<220> 
<223> TSG101 UBC domain

<400> 81
Ala Val Ser Glu Ser Gln Leu Lys Lys Met Val Ser Lys Tyr Lys Tyr 
1               5                   10                  15      
Arg Asp Leu Thr Val Arg Glu Thr Val Asn Val Ile Thr Leu Tyr Lys 
            20                  25                  30          
Asp Leu Lys Pro Val Leu Asp Ser Tyr Val Phe Asn Asp Gly Ser Ser 
        35                  40                  45              
Arg Glu Leu Met Asn Leu Thr Gly Thr Ile Pro Val Pro Tyr Arg Gly 
    50                  55                  60                  
Asn Thr Tyr Asn Ile Pro Ile Cys Leu Trp Leu Leu Asp Thr Tyr Pro 
65                  70                  75                  80  
Tyr Asn Pro Pro Ile Cys Phe Val Lys Pro Thr Ser Ser Met Thr Ile 
                85                  90                  95      
Lys Thr Gly Lys His Val Asp Ala Asn Gly Lys Ile Tyr Leu Pro Tyr 
            100                 105                 110         
Leu His Glu Trp Lys His Pro Gln Ser Asp Leu Leu Gly Leu Ile Gln 
        115                 120                 125             
Val Met Ile Val Val Phe Gly Asp Glu Pro Pro Val Phe Ser Arg Pro 
    130                 135                 140                 



<210> 82
<211> 166
<212> PRT
<213> Homo sapiens


<220> 
<223> UFC1 UBC domain

<400> 82
Ala Asp Glu Ala Thr Arg Arg Val Val Ser Glu Ile Pro Val Leu Lys 
1               5                   10                  15      
Thr Asn Ala Gly Pro Arg Asp Arg Glu Leu Trp Val Gln Arg Leu Lys 
            20                  25                  30          
Glu Glu Tyr Gln Ser Leu Ile Arg Tyr Val Glu Asn Asn Lys Asn Ala 
        35                  40                  45              
Asp Asn Asp Trp Phe Arg Leu Glu Ser Asn Lys Glu Gly Thr Arg Trp 
    50                  55                  60                  
Phe Gly Lys Cys Trp Tyr Ile His Asp Leu Leu Lys Tyr Glu Phe Asp 
65                  70                  75                  80  
Ile Glu Phe Asp Ile Pro Ile Thr Tyr Pro Thr Thr Ala Pro Glu Ile 
                85                  90                  95      
Ala Val Pro Glu Leu Asp Gly Lys Thr Ala Lys Met Tyr Arg Gly Gly 
            100                 105                 110         
Lys Ile Cys Leu Thr Asp His Phe Lys Pro Leu Trp Ala Arg Asn Val 
        115                 120                 125             
Pro Lys Phe Gly Leu Ala His Leu Met Ala Leu Gly Leu Gly Pro Trp 
    130                 135                 140                 
Leu Ala Val Glu Ile Pro Asp Leu Ile Gln Lys Gly Val Ile Gln His 
145                 150                 155                 160 
Lys Glu Lys Cys Asn Gln 
                165     

<210> 83
<211> 453
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2A UBC domain

<400> 83
tccaccccgg ctcggcggcg cctcatgcgg gacttcaaga ggttgcagga ggatcctcca      60

gccggagtca gcggggctcc gtccgagaac aacataatgg tgtggaacgc ggtcattttc     120

gggcctgaag ggaccccgtt tgaggatgga acatttaaac ttacaataga attcactgaa     180

gaatatccaa ataaaccacc tacagttaga tttgtctcta agatgttcca tccaaatgtc     240

tatgcagatg gtagtatatg tctggacata cttcagaacc gttggagtcc aacctatgat     300

gtgtcttcca ttctaacatc catacagtct ctgttggatg aacccaatcc caatagtcca     360

gcaaacagcc aggctgctca gctgtaccag gagaacaaac gggaatatga aaagcgtgtt     420

tctgcaatag tagaacaaag ctggcgtgat tgt                                  453


<210> 84
<211> 453
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2B UBC domain

<400> 84
agcacaccag ctcggcggag actgatgaga gacttcaagc ggctgcaaga ggaccctcct      60

gtgggagttt ctggcgcccc tagcgagaac aacatcatgc agtggaacgc cgtgatcttc     120

ggccctgagg gcaccccttt tgaggacggc accttcaagc tggtcatcga gttcagcgag     180

gaatacccca acaagcctcc taccgtgcgg ttcctgagca agatgtttca ccccaacgtg     240

tacgccgacg gcagcatctg tctggacatc ctgcagaaca gatggtcccc aacctacgat     300

gtgtccagca tcctgaccag catccagagc ctgctggacg agcccaatcc taacagccct     360

gccaattctc aggccgctca gctgtaccaa gagaacaagc gcgagtacga gaagcgggtg     420

tccgccatcg ttgagcagag ctggaatgac agc                                  453


<210> 85
<211> 534
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2C UBC domain

<400> 85
gccagccaga acagagatcc tgccgccaca tctgtggccg ctgctagaaa aggcgctgag      60

ccttctggcg gagctgccag aggacctgtg ggaaagagac tgcagcaaga gctgatgacc     120

ctgatgatga gcggcgacaa gggcatctcc gcctttccag agagcgacaa cctgttcaaa     180

tgggtcggaa ccatccacgg cgctgccggc acagtgtatg aggacctgag atacaagctg     240

agcctggaat ttcccagcgg ctacccctac aatgccccta ccgtgaagtt tctgacccct     300

tgctatcacc ccaacgtgga cacccagggc aacatctgcc tggacatcct gaaagagaag     360

tggagcgccc tgtacgatgt gcggacaatc ctgctgagca tccagtctct gctgggcgag     420

cccaacatcg acagccctct gaatactcac gccgccgagc tgtggaagaa ccccaccgcc     480

tttaagaagt acctgcaaga gacatacagc aagcaagtga ccagccaaga gcct           534


<210> 86
<211> 438
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2D1 UBC domain

<400> 86
gccctgaaga gaatccagaa agagctgagc gacctgcaga gagatcctcc tgctcactgt      60

tctgctggcc ctgtgggaga tgacctgttc cactggcaag ccaccatcat gggccctcca     120

gatagcgcct atcaaggcgg cgtgttcttc ctgaccgtgc acttccccac agactacccc     180

ttcaagcctc ctaagatcgc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gatatcgccc agatctacaa gagcgacaaa gagaagtaca accggcacgc cagagagtgg     420

acccagaaat acgctatg                                                   438


<210> 87
<211> 438
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2D2 UBC domain

<400> 87
gctctgaaga gaatccacaa agagctgaac gacctggcca gagatcctcc tgctcagtgt      60

tctgctggcc ctgtgggcga cgacatgttt cactggcaag ccaccatcat gggccccaac     120

gacagccctt atcaaggcgg cgtgttcttc ctgaccattc acttccccac agactacccc     180

ttcaagcctc ctaaggtggc cttcaccacc agaatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac catcagcaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gagatcgccc ggatctacaa gaccgacaga gagaagtaca accggatcgc cagagagtgg     420

acccagaaat acgccatg                                                   438


<210> 88
<211> 438
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2D3 UBC domain

<400> 88
gctctgaagc ggatcaacaa agagctgagc gacctggcca gagatcctcc tgctcagtgt      60

tctgctggcc ctgtgggcga cgacatgttt cactggcaag ccaccatcat gggccccaac     120

gacagccctt atcaaggcgg cgtgttcttc ctgaccattc acttccccac agactacccc     180

ttcaagcctc ctaaggtggc cttcaccacc agaatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac catcagcaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gagatcgccc ggatctacaa gaccgaccgg gacaagtaca accggatcag cagagagtgg     420

acccagaaat acgccatg                                                   438


<210> 89
<211> 438
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2D4 UBC domain

<400> 89
gctctgaaga gaatccagaa agagctgacc gacctgcagc gggaccctcc tgctcaatgt      60

tctgctggac ccgtgggcga cgacctgttt cattggcaag ccaccatcat gggccccaac     120

gacagccctt atcaaggcgg cgtgttcttc ctgaccattc acttccccac agactacccc     180

ttcaagcctc ctaaggtggc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gagatcgccc acacctacaa ggccgacaga gagaagtaca accggctggc cagagagtgg     420

acccagaaat acgctatg                                                   438


<210> 90
<211> 576
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2E1 UBC domain

<400> 90
agcgacgatg acagcagagc cagcacctct agcagcagca gctccagcag caatcagcag      60

accgagaaag agacaaacac gcccaagaaa aaagaaagca aggtgtccat gagcaagaac     120

agcaagctgc tgagcaccag cgccaagaga atccagaaag agctggccga catcacactg     180

gaccctccac ctaattgcag cgccggacct aagggcgaca acatctatga gtggcggagc     240

accatcctgg gaccacctgg ctctgtttat gaaggcggcg tgttcttcct ggacatcacc     300

ttcacacctg agtacccctt caagcctcct aaagtgacct tccggaccag aatctaccac     360

tgcaacatca acagccaggg cgtgatctgc ctggatatcc tgaaggacaa ttggagcccc     420

gctctgacca tcagcaaggt gctgctgtcc atctgcagcc tgctgaccga ctgcaatcct     480

gccgatcctc tcgtgggctc tatcgccaca cagtacatga ccaacagagc cgagcacgac     540

cggatggcca gacagtggac aaagagatac gccaca                               576


<210> 91
<211> 567
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2E2 UBC domain

<400> 91
agcacatctg gcggaagctc cgatggcgat cagagggaat ctgtgcagca agagcccgag      60

cgagaacagg tgcagcccaa gaagaaagag ggcaagatca gcagcaagac cgccgccaag     120

ctgagcacaa gcgccaagag aatccagaaa gagctggccg agatcacact ggaccctcca     180

cctaattgca gcgccggacc taagggcgac aacatctatg agtggcggag caccatcctg     240

ggaccacctg gctctgttta tgaaggcggc gtgttcttcc tggacatcac attcagccct     300

gactacccct tcaagcctcc taaagtgacc ttccggacca gaatctacca ctgcaacatc     360

aacagccagg gcgtgatctg cctggatatc ctgaaggaca attggagccc cgctctgacc     420

atcagcaagg tgctgctgag catctgcagc ctgctgaccg actgcaatcc tgccgatcct     480

ctcgtgggct ctatcgccac acagtacatg accaacagag ccgagcacga ccggatggcc     540

agacagtgga caaagagata cgccaca                                         567


<210> 92
<211> 447
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2E3 UBC domain

<400> 92
ttatccacta gtgctaaaag aattcagaag gagctagctg aaataaccct tgatcctcct      60

cctaattgca gtgctgggcc taaaggagat aacatttatg aatggagatc aactatactt     120

ggtccaccgg gttctgtata tgaaggtggt gtgttttttc tggatatcac attttcatca     180

gattatccat ttaagccacc aaaggttact ttccgcacca gaatctatca ctgcaacatc     240

aacagtcagg gagtcatctg tctggacatc cttaaagaca actggagtcc cgctttgact     300

atttcaaagg ttttgctgtc tatttgttcc cttttgacag actgcaaccc tgcggatcct     360

ctggttggaa gcatagccac tcagtatttg accaacagag cagaacacga caggatagcc     420

agacagtgga ccaagagata cgcaaca                                         447


<210> 93
<211> 480
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2F UBC domain

<400> 93
agcaccagac gggtgtcagt gcgggataag ctgctggtca aagaggtggc cgagctggaa      60

gccaacctgc cttgtacatg caaggtgcac ttccccgatc ctaacaagct gcactgcttt     120

cagctgaccg tgacacccga cgagggctac tatcaaggcg gcaagttcca gttcgagaca     180

gaggtgcccg acgcctacaa catggtgcct ccaaaagtga agtgcctgac caagatctgg     240

caccccaaca tcaccgagac aggcgagatc tgtctgagcc tgctgagaga gcacagcatc     300

gacggaacag gatgggcccc taccagaaca ctgaaggatg ttgtgtgggg cctgaactcc     360

ctgttcaccg acctgctgaa cttcgacgac cctctgaata tcgaggccgc cgagcaccac     420

ctgagagaca aagaggactt ccggaacaag gtggacgact acatcaagag atacgcccgg     480


<210> 94
<211> 459
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2G1 UBC domain

<400> 94
ctgctgctga gaaggcagct ggccgagctg aacaagaacc ccgtggaagg cttttctgcc      60

ggcctgatcg acgacaacga cctgtacaga tgggaagtgc tgatcatcgg ccctccagac     120

acactgtatg aaggcggcgt gttcaaggcc cacctgacat tccccaagga ctaccctctg     180

cggcctccta agatgaagtt catcaccgag atctggcacc ccaacgtgga caagaatggc     240

gacgtgtgca tcagcatcct gcacgagcct ggcgaggata agtacggcta cgagaagccc     300

gaggaacggt ggctgcctat ccacaccgtg gaaaccatca tgatcagcgt gatctccatg     360

ctggccgatc ctaacggcga cagccctgcc aatgtggatg ccgccaaaga gtggcgcgag     420

gacagaaacg gcgagttcaa gagaaaggtg gcccggtgt                            459


<210> 95
<211> 492
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2G2 UBC domain

<400> 95
gccggaacag ccctgaaaag actgatggcc gagtacaagc agctgaccct gaatcctcct      60

gagggcattg tggctggccc tatgaacgaa gagaacttct tcgagtggga agccctgatc     120

atgggccccg aggatacctg ctttgagttc ggagtgttcc ccgctatcct gagcttccct     180

ctggactacc ctctgagccc tcctaagatg cggtttacct gcgagatgtt tcaccccaac     240

atctaccccg acggcagagt gtgcatcagc attctgcatg cccctggcga cgaccctatg     300

ggctatgaat cttctgccga gcggtggtcc cctgtgcaga gcgtggaaaa gatcctgctg     360

agcgtggtgt ccatgctggc cgagcctaat gatgagagcg gcgccaatgt ggacgccagc     420

aaaatgtggc gggacgacag agagcagttc tacaagatcg ccaagcagat cgtgcagaag     480

tccctgggat tg                                                         492


<210> 96
<211> 477
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2H UBC domain

<400> 96
agctctccat ctcctggcaa gcggagaatg gacaccgacg tggtcaagct gatcgagagc      60

aagcacgaag tgaccatcct cggcggcctg aacgagttcg tcgtgaagtt ctatggaccc     120

cagggcaccc cttatgaagg cggcgtttgg aaagtgcgcg tggacctgcc tgacaagtac     180

ccctttaaga gccccagcat cggcttcatg aacaagatct ttcaccccaa catcgacgag     240

gccagcggca ccgtttgtct ggacgtgatc aaccagacct ggacagccct gtacgacctg     300

accaatatct tcgagagctt cctgcctcag ctgctggctt accccaatcc tatcgaccct     360

ctgaatggcg acgccgctgc catgtatctg cacagacccg aagagtacaa gcagaagatc     420

aaagagtaca tccagaagta cgccaccgag gaagccctga aagagcaaga ggaaggc        477


<210> 97
<211> 471
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2I UBC domain

<400> 97
agcggaattg ccctgagcag actggcccaa gagagaaagg cctggcggaa ggatcacccc      60

ttcggctttg tggccgtgcc taccaagaat cccgacggca ccatgaacct gatgaactgg     120

gagtgcgcta tccccggcaa gaagggcaca ccttgggaag gcggactgtt caagctgcgg     180

atgctgttca aggacgacta ccctagcagc cctcctaagt gcaagttcga gcctcctctg     240

tttcacccca acgtgtaccc tagcggcacc gtgtgtctga gcatcctgga agaggacaag     300

gattggaggc ccgccatcac catcaagcag atcctgctgg gcatccaaga gctgctgaac     360

gagcccaaca ttcaggaccc tgctcaggcc gaggcctaca ccatctactg ccagaacaga     420

gtggaatacg agaagagagt cagagcccag gccaagaagt tcgccccatc t              471


<210> 98
<211> 666
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2J1 UBC domain

<400> 98
gagacccgct acaacctgaa gagtccggct gttaaacgtt taatgaaaga agcggcagaa      60

ttgaaagatc caacagatca ttaccatgcg cagcctttag aggataacct ttttgaatgg     120

cacttcacgg ttagagggcc cccagactcc gattttgatg gaggagttta tcacgggcgg     180

atagtactgc caccagagta tcccatgaaa ccaccaagca ttattctcct aacggctaat     240

ggtcgatttg aagtgggcaa gaaaatctgt ttgagcatct caggccatca tcctgaaact     300

tggcagcctt cgtggagtat aaggacagca ttattagcca tcattgggtt tatgccaaca     360

aaaggagagg gagccatagg ttctctagat tacactcctg aggaaagaag agcacttgcc     420

aaaaaatcac aagatttctg ttgtgaagga tgtggctctg ccatgaagga tgtcctgttg     480

cctttaaaat ctggaagcga ttcaagccaa gctgaccaag aagccaaaga actggctagg     540

caaataagct ttaaggcaga agtcaattca tctggaaaga ctatctctga gtcagactta     600

aaccactctt tttcactaac tgatttacaa gatgatatac ctacaacatt ccagggtgct     660

acggcc                                                                666


<210> 99
<211> 552
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2J2 UBC domain

<400> 99
agcagcacca gctctaagag agcccctaca accgccacac agcggctgaa gcaggactac      60

ctgcggatca agaaagaccc cgtgccttac atctgcgccg agcctctgcc tagcaacatc     120

ctggaatggc actacgtcgt gcggggacct gagatgacac cttacgaagg cggctactac     180

cacggcaagc tgatcttccc cagagagttc ccattcaagc cacctagcat ctacatgatc     240

acccctaacg gccggttcaa gtgcaacacc agactgtgcc tgagcatcac cgactttcac     300

cccgacacct ggaatcccgc ttggagcgtg tccacaatcc tgacaggcct gctgagcttc     360

atggtggaaa agggccctac actgggcagc atcgagacaa gcgacttcac caagagacag     420

ctggccgtgc agagcctggc cttcaacctg aaggacaagg tgttctgcga gctgttcccc     480

gaggtggtgg aagagatcaa gcagaagcag aaggcccagg acgagctgag cagcagacct     540

caaacactgc ct                                                         552


<210> 100
<211> 597
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2K UBC domain

<400> 100
gccaatatcg ccgtgcagag aatcaagcgc gagttcaaag aggtgctgaa gtccgaggaa      60

accagcaaga accagatcaa ggtggacctg gtggacgaga acttcaccga gctgagaggc     120

gagattgccg gacctcctga cacaccttat gaaggcggca gataccagct ggaaatcaag     180

atccccgaga catacccctt caatcctcca aaagtgcggt tcatcaccaa gatctggcac     240

cccaacatca gcagcgtgac cggcgccatc tgtctggaca tcctgaagga tcagtgggcc     300

gctgccatga cactgagaac agttctgctg agtctgcagg ccctgctggc tgctgctgaa     360

cctgatgatc cacaggatgc cgtggtggcc aaccagtaca agcagaaccc cgagatgttc     420

aagcagaccg ccagactgtg ggcccatgtg tatgctggtg ctcccgttag cagccccgag     480

tacaccaaga aaatcgagaa cctgtgcgcc atgggcttcg acagaaacgc cgtgattgtg     540

gccctgagca gcaagagctg ggatgtcgaa acagccaccg aactgctgct gtccaac        597


<210> 101
<211> 459
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2L3 UBC domain

<400> 101
gccgctagtc ggagactgat gaaggaactg gaagagatcc ggaagtgcgg catgaagaac      60

ttccggaaca tccaggtgga cgaggccaac ctgctgacat ggcagggact gatcgtgccc     120

gacaatcctc cttacgacaa gggcgccttc agaatcgaga tcaacttccc cgccgagtat     180

cccttcaagc ctcctaagat caccttcaag accaagatct atcaccccaa catcgacgag     240

aagggccaag tgtgcctgcc tgtgatcagc gccgagaatt ggaagcctgc caccaagacc     300

gaccaagtga tccagtctct gatcgccctg gtcaacgacc ctcagcctga acatcctctg     360

agagccgatc tggccgaaga gtacagcaag gaccggaaga agttctgcaa gaacgctgaa     420

gagttcacca agaagtacgg cgagaagcgg cccgtggat                            459


<210> 102
<211> 456
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2L6 UBC domain

<400> 102
atggccagca tgcgggtcgt gaaagagctg gaagatctgc agaagaagcc tcctccttac      60

ctgcggaacc tgagcagcga cgatgccaat gtgcttgtgt ggcatgccct gctgctgccc     120

gatcagcctc cttatcacct gaaggccttt aacctgcgga tcagcttccc acctgagtac     180

cccttcaagc ctcctatgat caagttcacc accaagatct atcaccccaa cgtggacgag     240

aacggccaga tctgcctgcc tatcatcagc agcgagaact ggaagccctg caccaagacc     300

tgccaggtgc tggaagctct gaacgtgctg gtcaacagac ccaacatccg cgagcctctg     360

agaatggacc tggccgatct gctgacacag aaccccgagc tgttccggaa gaacgccgaa     420

gagttcaccc tgagattcgg cgtggacaga cctagc                               456


<210> 103
<211> 471
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2M UBC domain

<400> 103
gcctctgctg cccagctgag aatccagaag gacatcaacg agctgaacct gcctaagacc      60

tgcgacatca gcttcagcga ccccgacgac ctgctgaact tcaagctggt catctgcccc     120

gacgagggct tctacaagag cggcaagttc gtgttcagct tcaaagtcgg ccagggctac     180

cctcacgacc ctccaaaagt gaagtgcgag acaatggtgt atcaccccaa catcgacctg     240

gaaggcaacg tgtgcctgaa catcctgcgc gaggattgga agcccgtgct gaccatcaac     300

agcatcatct acggcctgca gtacctgttc ctggaaccta atcctgagga ccctctgaac     360

aaagaggccg ccgaagtcct gcagaacaac agaaggctgt tcgagcagaa cgtgcagcgg     420

tctatgagag gcggctacat tggcagcacc tacttcgaga gatgcctgaa g              471


<210> 104
<211> 453
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2N UBC domain

<400> 104
gccgggctgc cccgcaggat catcaaggaa acccagcgtt tgctggcaga accagttcct      60

ggcatcaaag ccgaaccaga tgagagcaac gcccgttatt ttcatgtggt cattgctggc     120

cctcaggatt ccccctttga gggagggact tttaaacttg aactattcct tccagaagaa     180

tacccaatgg cagcccctaa agtacgtttc atgaccaaaa tttatcatcc taatgtagac     240

aagttgggaa gaatatgttt agatattttg aaagataagt ggtccccagc actgcagatc     300

cgcacagttc tgctatcgat ccaggccttg ttaagtgctc ccaatccaga tgatccatta     360

gcaaatgatg tagcggagca gtggaagacc aacgaagccc aagccataga aacagctaga     420

gcatggacta ggctatatgc catgaataat att                                  453


<210> 105
<211> 456
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2NL UBC domain

<400> 105
gccgagctgc cccacaggat catcaaggaa acccagcgtt tgctggcaga gccagttcct      60

ggcatcaaag cagaaccaga tgaaagcaac gcccgttatt ttcatgtggt cattgctggg     120

gaatcaaagg attccccctt tgagggaggg acttttaaac gtgaactatt acttgcagaa     180

gaatacccaa tggcagcccc taaagtacgt ttcatgacca aaatttatca tccaaatgta     240

gacaagttgg aaagaataag tttagatatt ttgaaagata agtggtcccc agccctgcag     300

atccgcacag ttctgctatc gatccaggcc ttgttaaatg ctcccaatcc agatgatcca     360

ttagcaaatg atgtagtgga gcagtggaag accaacgaag cccaagccat tgaaacagct     420

agagcatgga ctaggctata tgccatgaat agtatt                               456


<210> 106
<211> 414
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2O UBC domain

<400> 106
agcaaccaca gcttcaagaa gatcgagttc cagccacctg aggccaagaa attcttcagc      60

accgtgcgga aagagatggc cctgctggct acatctctgc ccgagggcat catggtcaag     120

accttcgagg accggatgga cctgttcagc gccctgatca agggccccac cagaacacct     180

tatgaggacg gcctgtacct gttcgacatc cagctgccta acatctaccc cgccgtgcct     240

ccacacttct gctacctgtc tcagtgcagc ggcagactga accccaacct gtacgacaac     300

ggcaaagtgt gcgtgtccct gctcggcaca tggatcggaa agggcaccga gagatggacc     360

agcaagtcta gcctgctgca ggtcctgatc agcatccagg gactgatcct ggtg           414


<210> 107
<211> 504
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2Q1 UBC domain

<400> 107
agcggatctg tgcaggccac cgaccggctt atgaaggaac tgcgggacat ctacagaagc      60

cagagcttca aaggcggcaa ctacgccgtg gaactggtca acgacagcct gtacgactgg     120

aacgtgaagc tgctgaaggt ggaccaggat agcgccctgc acaacgacct gcagatcctg     180

aaagagaaag agggcgccga cttcatcctg ctgaacttca gcttcaagga caacttcccc     240

ttcgatcctc cattcgtgcg cgtggtgtct cctgttctgt ctggcggata tgtgcttggc     300

ggcggagcca tctgtatgga actgctgaca aagcaaggct ggtccagcgc ctacagcatc     360

gagagcgtga tcatgcagat cagcgccaca ctggtcaagg gcaaagccag agtgcagttc     420

ggcgccaaca agagccagta cagcctgaca agagcccagc agagctacaa gtccctggtg     480

cagatccacg agaagaacgg ctgg                                            504


<210> 108
<211> 501
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2Q2 UBC domain

<400> 108
ggcgctgtgt ctggatctgt gcaggcctct gaccggctga tgaaggaact gcgggacatc      60

tacagaagcc agagctacaa gaccggcatc tacagcgtgg aactgatcaa cgacagcctg     120

tacgactggc acgtgaagct gcagaaggtg gaccctgata gccctctgca cagcgacctg     180

cagatcctga aagagaaaga gggcatcgag tacatcctgc tgaacttcag cttcaaggac     240

aacttcccct tcgatcctcc attcgtgcgc gtggtgctgc ctgttctgtc tggcggatat     300

gtgcttggag gcggagccct gtgtatggaa ctgctgacaa agcaaggctg gtccagcgcc     360

tacagcatcg agagcgtgat catgcagatc aacgccacac tggtcaaggg caaagccaga     420

gtgcagttcg gcgccaacaa gaaccagtac aacctggcta gagcccagca gtcctacaac     480

agcatcgtgc agatccacga a                                               501


<210> 109
<211> 480
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2QL UBC domain

<400> 109
aaggagctgc aggacatcgc gcgccttagc gaccgcttca tctccgtgga gctggtggac      60

gagagcctgt tcgactggaa cgtgaagctg caccaggtgg acaaggactc ggtgctgtgg     120

caggacatga aggagaccaa caccgagttc atcctgctca acctcacctt ccccgacaac     180

ttccccttct cgccgccctt catgcgggtg ctcagcccgc gcctggagaa cggctacgtg     240

ctggacggcg gcgccatctg catggagctg ctcacgccgc gcggctggtc cagcgcctac     300

accgtggagg ccgtcatgcg ccagttcgca gccagcctgg tcaagggcca gggacggatc     360

tgtagaaaag ctggcaaatc aaaaaagtcc ttcagtcgca aggaagctga agctaccttt     420

aagagtttgg tgaagacgca tgaaaaatat ggttgggtca ccccgcccgt gtccgacggc     480


<210> 110
<211> 534
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2R1 UBC domain

<400> 110
cctagctctc agaaggccct gctgctggaa ctgaagggcc tgcaagagga acccgtggaa      60

ggcttcagag tgaccctggt ggatgagggc gacctgtaca attgggaagt cgccatcttc     120

ggccctccaa acacctacta cgaaggcggc tacttcaagg cccggctgaa gttccccatc     180

gactaccctt atagccctcc tgccttccgg ttcctgacca agatgtggca ccccaacatc     240

tacgagacag gcgacgtgtg catcagcatt ctgcaccctc cagtggacga tcctcagtct     300

ggcgagctgc caagcgagag atggaacccc acacagaacg tgcggaccat cctgctgagc     360

gtgatcagcc tgctgaacga gcccaacaca ttcagccccg ccaatgtgga tgccagcgtg     420

atgtaccgga agtggaaaga gtccaagggc aaagacagag agtacaccga catcatccgg     480

aaacaggtgc tgggcacaaa ggtggacgcc gagcgagatg gcgtgaaagt tcct           534


<210> 111
<211> 573
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2R2 UBC domain

<400> 111
accagctcgc agaaggccct gatgctcgag ctgaaatccc tgcaggagga accggtggag      60

ggcttccgga tcaccctggt ggacgagtcc gacctctaca actgggaggt ggccatcttc     120

ggacccccca acaccctcta cgaaggcggc tacttcaagg cgcatattaa atttcctatt     180

gactacccct attcaccacc taccttcaga ttcttgacca aaatgtggca ccccaacatt     240

tatgagaatg gagatgtatg catttcgatt cttcatccgc ctgtagatga cccacagagt     300

ggagaactgc cttctgaaag gtggaatcct actcagaatg tgaggactat cctattaagt     360

gtaatctcac tgcttaatga gcccaacacc ttctccccag ccaatgtcga tgcttcagtt     420

atgttcagga aatggagaga cagtaaagga aaagacaaag aatatgctga aattattagg     480

aaacaagttt cagccactaa ggccgaagca gaaaaggatg gagtgaaggt ccccacaacc     540

ctggcggaat actgcatcaa aactaaagtg cct                                  573


<210> 112
<211> 465
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2S UBC domain

<400> 112
aacagcaacg tggaaaacct gcctcctcac atcatccggc tggtgtacaa agaagtgacc      60

acactgaccg ccgatcctcc agacggcatc aaggtgttcc ccaacgaaga ggacctgacc     120

gacctgcaag tgaccatcga aggccctgag ggcacacctt atgctggcgg cctgttcaga     180

atgaagctgc tgctgggcaa agacttcccc gcatctcctc caaagggcta cttcctgacc     240

aagatctttc accccaacgt gggcgccaac ggcgagatct gtgtgaacgt gctgaagaga     300

gactggaccg ccgagctggg aatcagacac gtgctgctga ccatcaagtg cctgctgatt     360

caccctaatc ctgagagcgc cctgaacgag gaagctggca gactgctgct cgaaaactac     420

gaggaatacg ccgccagagc caggctgctg acagagattc atgga                     465


<210> 113
<211> 498
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2T UBC domain

<400> 113
cagagagcca gcagactgaa gcgcgagctg catatgctgg ccacagaacc tccacctggc      60

atcacctgtt ggcaggacaa ggaccagatg gacgacctga gagcccagat tctcggcgga     120

gccaacacac cttatgagaa gggcgtgttc aagctggaag tgatcatccc cgagagatac     180

cccttcgagc ctcctcagat ccggtttctg acccctatct atcaccccaa catcgacagc     240

gccggcagaa tctgtctgga cgtgctgaag ctgcctccta aaggcgcttg gaggcccagc     300

ctgaatatcg ccacagtgct gaccagcatc cagctgctga tgagcgagcc caatcctgac     360

gatcccctga tggccgatat cagcagcgag ttcaagtaca acaagcccgc cttcctgaag     420

aacgccagac agtggacaga gaagcacgcc cggcagaagc agaaggccga cgaggaagag     480

atgctggaca acctgcct                                                   498


<210> 114
<211> 447
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2U UBC domain

<400> 114
cacggcagag cctatctgct gctgcacaga gatttctgcg acctgaaaga gaacaactac      60

aagggcatca ccgccaagcc tgtgtccgag gacatgatgg aatgggaagt cgagatcgag     120

ggcctgcaga actctgtgtg gcagggcctt gtgttccagc tgaccatcca cttcaccagc     180

gagtacaact acgcccctcc tgtggtcaag ttcatcacaa tcccttttca ccccaacgtg     240

gaccctcaca ccggccagcc ttgcatcgac tttctggaca accccgagaa gtggaacacc     300

aactacaccc tgagcagcat cctgctggcc ctgcaagtga tgctgagcaa ccccgtgctg     360

gaaaaccccg tgaatctgga agccgccaga atcctggtca aggacgagag cctgtaccgg     420

accatcctgc ggctgttcaa cagacct                                         447


<210> 115
<211> 420
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2V1 UBC domain

<400> 115
ggagtaaaag tccctcgcaa tttccgactg ttggaagaac tcgaagaagg ccagaaagga      60

gtaggagatg gcacagttag ctggggtcta gaagatgacg aagacatgac acttacaaga     120

tggacaggga tgataattgg gcctccaaga acaatttatg aaaaccgaat atacagcctt     180

aaaatagaat gtggacctaa atacccagaa gcacccccct ttgtaagatt tgtaacaaaa     240

attaatatga atggagtaaa tagttctaat ggagtggtgg acccaagagc catatcagtg     300

ctagcaaaat ggcagaattc atatagcatc aaagttgtcc tgcaagagct tcggcgccta     360

atgatgtcta aagaaaatat gaaactccct cagccgcccg aaggacagtg ttacagcaat     420


<210> 116
<211> 432
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2V2 UBC domain

<400> 116
gccgtgtcta caggcgtgaa ggtgcccaga aacttccggc tgctggaaga actggaagag      60

ggccagaaag gcgtcggaga tggcacagtg tcttggggcc tcgaagatga cgaggacatg     120

accctgacca gatggaccgg catgatcatc ggccctccac ggaccaacta cgagaaccgg     180

atctactccc tgaaggtgga atgcggccct aagtaccctg aggctcctcc tagcgtcaga     240

ttcgtgacca agatcaacat gaacggcatc aacaacagca gcggcatggt ggacgccaga     300

tctattcctg tgctggccaa gtggcagaac agctacagca tcaaggtggt gctgcaagag     360

ctgcggcggc tgatgatgag caaagaaaac atgaagctgc cccagccacc tgagggacag     420

acctacaaca at                                                         432


<210> 117
<211> 348
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2W UBC domain

<400> 117
gccagcatgc agaagcggct gcagaaagaa ctgctggccc tgcagaacga tcctcctcct      60

ggcatgaccc tgaacgagaa gtccgtgcag aacagcatca cccagtggat cgtggacatg     120

gaaggcgccc ctggcacact gtatgagggc gagaaattcc agctgctgtt caagttcagc     180

agcagatacc ccttcgacag ccctcaagtg atgttcaccg gcgagaacat ccctgtgcac     240

cctcacgtgt acagcaacgg ccacatctgc ctgagcatcc tgaccgagga ttggagccct     300

gctctgagcg tgcagagcgt gtgtctgagc atcatctcca tgctgagc                  348


<210> 118
<211> 435
<212> DNA
<213> Homo sapiens


<220> 
<223> UBE2Z UBC domain

<400> 118
atgtccattt ataaggagcc tcctccagga atgttcgttg tacctgatac tgttgacatg      60

actaagattc atgcattgat cacaggccca tttgacactc cttatgaagg gggtttcttc     120

ctgttcgtgt ttcggtgtcc gcccgactat cccatccacc cacctcgggt caaactgatg     180

acaacgggca ataacacagt gaggtttaac cccaacttct accgcaatgg gaaagtctgc     240

ttgagtattc taggtacatg gactggacct gcctggagcc cagcccagag catctcctca     300

gtgctcatct ctatccagtc cctgatgact gagaacccct atcacaatga gcccggcttt     360

gaacaggaga gacatccagg agacagcaaa aactataatg aatgtatccg gcacgagacc     420

atcagagttg cagtc                                                      435


<210> 119
<211> 1059
<212> DNA
<213> Homo sapiens


<220> 
<223> UEVLD UBC domain

<400> 119
gagttcgact gcgagggcct gagacggctg cttggcaagt acaagttcag ggacctaact      60

gtggaagaac taaggaatgt aaatgtattt ttcccacatt tcaaatattc catggacacc     120

tatgttttta aagatagttc tcagaaagac ctgctgaatt ttactggcac aattcctgtg     180

atgtatcagg gtaatacata taacatacca attcgtttct ggattttgga ttctcaccct     240

ttcgctcccc ctatttgctt cttgaagcca actgcaaata tgggaatctt agtcggaaaa     300

catgtggatg ctcaaggcag aatatatttg ccctatctcc aaaactggag ccatcctaaa     360

tctgtcattg ttggattaat taaagaaatg attgccaagt ttcaagagga acttcccatg     420

tattctctat catcatctga tgaggcacgg caggtagact tgctagccta tattgcaaaa     480

atcactgaag gtgtttcaga tacaaattca aagagctggg caaatcatga gaataaaaca     540

gtcaataaaa ttactgtggt tggaggtgga gaactcggta ttgcctgcac attagcaatt     600

tcagcaaagg gtattgcaga caggcttgtc ctcttagacc tctcagaagg gactaaagga     660

gccacgatgg accttgaaat cttcaacctt cctaatgtgg agatcagcaa agatttgtct     720

gcctctgctc attccaaggt ggtgatcttc acagtcaact ctttgggtag ttctcagtcg     780

taccttgatg tggtacagag caatgtggat atgttcagag cccttgtccc agctctggga     840

cattatagtc aacacagtgt cctgctcgtt gcatctcaac cagtggaaat catgacctat     900

gtaacatgga aactgagtac atttcctgca aatcgagtga tcggaattgg atgtaatctg     960

gattcacaga gattacagta tattattaca aatgttttga aggcacagac ttcaggcaaa    1020

gaagtatggg ttattggcga gcaaggagaa gacaaagtg                           1059


<210> 120
<211> 609
<212> DNA
<213> Homo sapiens


<220> 
<223> BIRC6 UBC domain

<400> 120
gccaatcaag agaagaagct gggcgagtac agcaagaaag ccgccatgaa gcccaagcct      60

ctgagcgtgc tgaagtccct ggaagagaaa tacgtggccg tgatgaagaa gctccagttc     120

gacaccttcg agatggtgtc cgaggacgag gatggcaagc tgggcttcaa agtgaactac     180

cactacatga gccaagtgaa gaacgccaac gacgccaact ctgccgccag agctagaagg     240

ctggctcaag aagccgtgac tctgagcaca agcctgccac tgagcagcag cagctccgtg     300

ttcgtcagat gtgacgagga acggctggac atcatgaagg tgctgatcac aggccctgcc     360

gacacacctt acgccaatgg ctgcttcgag ttcgacgtgt acttccctca agactaccct     420

agcagccctc ctctggtcaa cctggaaaca acaggcggac acagcgtgcg gttcaacccc     480

aacctgtaca acgacggcaa agtgtgcctg agcatcctga acacctggca cggcagaccc     540

gaggaaaagt ggaatcctca gaccagcagc ttcctgcagg tcctggtgtc tgtgcagagc     600

ctgattctg                                                             609


<210> 121
<211> 606
<212> DNA
<213> Homo sapiens


<220> 
<223> FTS UBC domain

<400> 121
cctccacgaa ctgcaccaaa gaaacagctg ccttctattc ccaaaaatgc tttgcccata      60

actaagccta catctcctgc cccagcagca cagtcaacaa atggcacgca tgcgtcctat     120

ggacccttct acctggaata ctctcttctt gcagaattta ccttggttgt gaagcagaag     180

ctaccaggcg tctatgtgca gccatcttat cgctctgcat taatgtggtt tggagtaata     240

ttcatacggc atggacttta ccaagatggc gtatttaagt ttacagttta catccctgat     300

aactatccag atggtgactg tccacgcttg gtgttcgata ttcctgtctt tcacccgcta     360

gttgatccca cctcaggtga gctggatgtg aagagagcat ttgcaaaatg gaggcggaac     420

cataatcata tttggcaggt attaatgtat gcaaggagag ttttctacaa gattgataca     480

gcaagccccc tgaacccaga ggctgcagta ctgtatgaaa aagatattca gctttttaaa     540

agtaaagttg ttgacagtgt taaggtgtgc actgctcgtt tgtttgacca acctaaaata     600

gaagac                                                                606


<210> 122
<211> 432
<212> DNA
<213> Homo sapiens


<220> 
<223> TSG101 UBC domain

<400> 122
gccgtgtctg agagccagct gaagaaaatg gtgtccaagt acaagtaccg ggacctgacc      60

gtgcgggaaa ccgtgaatgt gatcaccctg tacaaggacc tgaagcctgt gctggacagc     120

tacgtgttca acgatggcag cagccgcgag ctgatgaacc tgacaggcac aatccccgtg     180

ccttaccggg gcaacaccta caacatcccc atctgcctgt ggctgctgga cacatacccc     240

tacaatcctc caatctgctt cgtgaagccc accagcagca tgaccatcaa gaccggcaaa     300

cacgtggacg ccaacggcaa gatctacctg ccttacctgc acgagtggaa gcaccctcag     360

tctgatctgc tgggcctgat ccaagtgatg atcgtggtgt tcggcgacga gcctcctgtg     420

ttcagtagac ct                                                         432


<210> 123
<211> 498
<212> DNA
<213> Homo sapiens


<220> 
<223> UFC1 UBC domain

<400> 123
gccgatgagg ccacacgaag agtggtgtct gagatccccg tgctgaaaac aaacgctggc      60

cccagagaca gagaactgtg ggtgcagcgg ctgaaagagg aataccagag cctgatccgc     120

tacgtcgaga acaacaagaa cgccgacaac gactggttcc ggctggaaag caacaaagaa     180

ggcacccgtt ggttcggcaa gtgctggtac atccacgacc tgctgaagta cgagttcgac     240

atcgagttcg atatccccat cacatacccc accaccgctc cagagattgc cgtgcctgag     300

ctggatggca agaccgccaa gatgtacaga ggcggcaaga tctgcctgac cgaccacttc     360

aaacccctgt gggccagaaa cgtgcccaag tttggactgg cccatctgat ggccctcgga     420

cttggacctt ggctggccgt ggaaatcccc gacctgattc agaaaggcgt gatccagcac     480

aaagagaagt gcaaccag                                                   498


<210> 124
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; Haemagglutinin tag

<400> 124
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   

<210> 125
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; Glu-Glu epitope tag

<400> 125
Cys Glu Glu Glu Glu Tyr Met Pro Met Glu 
1               5                   10  

<210> 126
<211> 94
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; aCS3 targeting domain

<400> 126
Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      
Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr 
            20                  25                  30          
Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu 
        35                  40                  45              
Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  
Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser 
65                  70                  75                  80  
Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  

<210> 127
<211> 98
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; aCS3_full

<400> 127
Glu Phe Ala Met Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala 
1               5                   10                  15      
Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr 
            20                  25                  30          
Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp 
        35                  40                  45              
Val Trp Gln Glu Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile 
    50                  55                  60                  
Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly 
65                  70                  75                  80  
Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr 
                85                  90                  95      
Arg Thr 
        

<210> 128
<211> 94
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; aCS3(V33R) targeting domain

<400> 128
Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      
Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr 
            20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu 
        35                  40                  45              
Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  
Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser 
65                  70                  75                  80  
Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  

<210> 129
<211> 94
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; aCS3(K7Q) targeting domain

<400> 129
Val Ser Ser Val Pro Thr Gln Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      
Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr 
            20                  25                  30          
Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu 
        35                  40                  45              
Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  
Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser 
65                  70                  75                  80  
Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  

<210> 130
<211> 94
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; aCS3(K55Y) targeting domain

<400> 130
Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      
Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr 
            20                  25                  30          
Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu 
        35                  40                  45              
Phe Glu Val Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  
Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser 
65                  70                  75                  80  
Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  

<210> 131
<211> 94
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; aCS3(K64H) targeting domain

<400> 131
Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      
Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr 
            20                  25                  30          
Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu 
        35                  40                  45              
Phe Glu Val Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu His 
    50                  55                  60                  
Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser 
65                  70                  75                  80  
Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  

<210> 132
<211> 94
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; aCS3(K7Q/K55Y) targeting domain

<400> 132
Val Ser Ser Val Pro Thr Gln Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      
Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr 
            20                  25                  30          
Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu 
        35                  40                  45              
Phe Glu Val Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  
Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser 
65                  70                  75                  80  
Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  

<210> 133
<211> 94
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; aCS3(K7Q/K64H) targeting domain

<400> 133
Val Ser Ser Val Pro Thr Gln Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      
Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr 
            20                  25                  30          
Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu 
        35                  40                  45              
Phe Glu Val Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu His 
    50                  55                  60                  
Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser 
65                  70                  75                  80  
Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  

<210> 134
<211> 94
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; aCS3(K55Y/K64H) targeting domain

<400> 134
Val Ser Ser Val Pro Thr Gln Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      
Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr 
            20                  25                  30          
Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu 
        35                  40                  45              
Phe Glu Val Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu His 
    50                  55                  60                  
Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser 
65                  70                  75                  80  
Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  

<210> 135
<211> 94
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; ACS3 (K7Q/K55Y/K64H) targeting domain

<400> 135
Val Ser Ser Val Pro Thr Gln Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      
Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr 
            20                  25                  30          
Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu 
        35                  40                  45              
Phe Glu Val Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu His 
    50                  55                  60                  
Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser 
65                  70                  75                  80  
Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  

<210> 136
<400> 136
000

<210> 137
<400> 137
000

<210> 138
<211> 156
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; K19 targeting domain

<400> 138
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Ser Asp 
            20                  25                  30          
Arg Trp Gly Trp Thr Pro Leu His Leu Ala Ala Trp Trp Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Arg Gly Ala Asp Val Ser Ala Ala 
    50                  55                  60                  
Asp Leu His Gly Gln Ser Pro Leu His Leu Ala Ala Met Val Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Thr Met Gly Ala Thr Pro Leu His Leu Ala Ala Arg Ser Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Glu Leu Leu Lys Asn Gly Ala Asp Met Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Thr Phe Asp Ile Ser Thr Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu 
145                 150                 155     

<210> 139
<211> 154
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; E3_5 targeting domain

<400> 139
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Thr Asp 
            20                  25                  30          
Asn Asp Gly Tyr Thr Pro Leu His Leu Ala Ala Ser Asn Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Ser 
    50                  55                  60                  
Asp Leu Thr Gly Ile Thr Pro Leu His Leu Ala Ala Ala Thr Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Tyr Asp Asn Asp Gly His Thr Pro Leu His Leu Ala Ala Lys Tyr Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln 
145                 150                 

<210> 140
<400> 140
000

<210> 141
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; Linker 1 (Short)

<400> 141
Leu Glu Gly Gly Gly Gly Ser Ser Arg 
1               5                   

<210> 142
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; Linker 2 (Long)

<400> 142
Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      
Ser Ser Arg 
            

<210> 143
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; Linker 3

<400> 143
Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      
Gly Ser Gly Thr 
            20  

<210> 144
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; Linker 4

<400> 144
Gly Gly Gly Gly Gly 
1               5   

<210> 145
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; Linker 5

<400> 145
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210> 146
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; Linker 6

<400> 146
Gly Gly Gly Gly Ser 
1               5   

<210> 147
<211> 214
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; VHL regulation domain

<400> 147
Ala Met Pro Arg Arg Ala Glu Asn Trp Asp Glu Ala Glu Val Gly Ala 
1               5                   10                  15      
Glu Glu Ala Gly Val Glu Glu Tyr Gly Pro Glu Glu Asp Gly Gly Glu 
            20                  25                  30          
Glu Ser Gly Ala Glu Glu Ser Gly Pro Glu Glu Ser Gly Pro Glu Glu 
        35                  40                  45              
Leu Gly Ala Glu Glu Glu Met Glu Val Gly Arg Pro Arg Pro Val Leu 
    50                  55                  60                  
Arg Ser Val Asn Ser Arg Glu Pro Ser Gln Val Ile Phe Cys Asn Arg 
65                  70                  75                  80  
Ser Pro Arg Val Val Leu Pro Val Trp Leu Asn Phe Asp Gly Glu Pro 
                85                  90                  95      
Gln Pro Tyr Pro Thr Leu Pro Pro Gly Thr Gly Arg Arg Ile His Ser 
            100                 105                 110         
Tyr Arg Gly His Leu Trp Leu Phe Arg Asp Ala Gly Thr His Asp Gly 
        115                 120                 125             
Leu Leu Val Asn Gln Thr Glu Leu Phe Val Pro Ser Leu Asn Val Asp 
    130                 135                 140                 
Gly Gln Pro Ile Phe Ala Asn Ile Thr Leu Pro Val Tyr Thr Leu Lys 
145                 150                 155                 160 
Glu Arg Cys Leu Gln Val Val Arg Ser Leu Val Lys Pro Glu Asn Tyr 
                165                 170                 175     
Arg Arg Leu Asp Ile Val Arg Ser Leu Tyr Glu Asp Leu Glu Asp His 
            180                 185                 190         
Pro Asn Val Gln Lys Asp Leu Glu Arg Leu Thr Gln Glu Arg Ile Ala 
        195                 200                 205             
His Gln Arg Met Gly Asp 
    210                 

<210> 148
<211> 146
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; UBE2D1(C85A) regulation domain

<400> 148
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Ala Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met 
145     

<210> 149
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_aCS3 control

<400> 149
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Glu Phe Ala Met Val Ser Ser 
1               5                   10                  15      
Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu 
            20                  25                  30          
Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr 
        35                  40                  45              
Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val 
    50                  55                  60                  
Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val 
65                  70                  75                  80  
Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr 
                85                  90                  95      
Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
            100                 105         

<210> 150
<211> 165
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_K19 control

<400> 150
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asp Leu Gly Lys Lys Leu Leu 
1               5                   10                  15      
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala 
            20                  25                  30          
Asn Gly Ala Asp Val Asn Ala Ser Asp Arg Trp Gly Trp Thr Pro Leu 
        35                  40                  45              
His Leu Ala Ala Trp Trp Gly His Leu Glu Ile Val Glu Val Leu Leu 
    50                  55                  60                  
Lys Arg Gly Ala Asp Val Ser Ala Ala Asp Leu His Gly Gln Ser Pro 
65                  70                  75                  80  
Leu His Leu Ala Ala Met Val Gly His Leu Glu Ile Val Glu Val Leu 
                85                  90                  95      
Leu Lys Tyr Gly Ala Asp Val Asn Ala Lys Asp Thr Met Gly Ala Thr 
            100                 105                 110         
Pro Leu His Leu Ala Ala Arg Ser Gly His Leu Glu Ile Val Glu Glu 
        115                 120                 125             
Leu Leu Lys Asn Gly Ala Asp Met Asn Ala Gln Asp Lys Phe Gly Lys 
    130                 135                 140                 
Thr Thr Phe Asp Ile Ser Thr Asp Asn Gly Asn Glu Asp Leu Ala Glu 
145                 150                 155                 160 
Ile Leu Gln Lys Leu 
                165 

<210> 151
<211> 163
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_E3_5 control

<400> 151
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asp Leu Gly Lys Lys Leu Leu 
1               5                   10                  15      
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala 
            20                  25                  30          
Asn Gly Ala Asp Val Asn Ala Thr Asp Asn Asp Gly Tyr Thr Pro Leu 
        35                  40                  45              
His Leu Ala Ala Ser Asn Gly His Leu Glu Ile Val Glu Val Leu Leu 
    50                  55                  60                  
Lys Asn Gly Ala Asp Val Asn Ala Ser Asp Leu Thr Gly Ile Thr Pro 
65                  70                  75                  80  
Leu His Leu Ala Ala Ala Thr Gly His Leu Glu Ile Val Glu Val Leu 
                85                  90                  95      
Leu Lys His Gly Ala Asp Val Asn Ala Tyr Asp Asn Asp Gly His Thr 
            100                 105                 110         
Pro Leu His Leu Ala Ala Lys Tyr Gly His Leu Glu Ile Val Glu Val 
        115                 120                 125             
Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys 
    130                 135                 140                 
Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu 
145                 150                 155                 160 
Ile Leu Gln 
            

<210> 152
<211> 326
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_VHL_Linker 1_aCS3

<400> 152
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Met Pro Arg Arg Ala Glu 
1               5                   10                  15      
Asn Trp Asp Glu Ala Glu Val Gly Ala Glu Glu Ala Gly Val Glu Glu 
            20                  25                  30          
Tyr Gly Pro Glu Glu Asp Gly Gly Glu Glu Ser Gly Ala Glu Glu Ser 
        35                  40                  45              
Gly Pro Glu Glu Ser Gly Pro Glu Glu Leu Gly Ala Glu Glu Glu Met 
    50                  55                  60                  
Glu Val Gly Arg Pro Arg Pro Val Leu Arg Ser Val Asn Ser Arg Glu 
65                  70                  75                  80  
Pro Ser Gln Val Ile Phe Cys Asn Arg Ser Pro Arg Val Val Leu Pro 
                85                  90                  95      
Val Trp Leu Asn Phe Asp Gly Glu Pro Gln Pro Tyr Pro Thr Leu Pro 
            100                 105                 110         
Pro Gly Thr Gly Arg Arg Ile His Ser Tyr Arg Gly His Leu Trp Leu 
        115                 120                 125             
Phe Arg Asp Ala Gly Thr His Asp Gly Leu Leu Val Asn Gln Thr Glu 
    130                 135                 140                 
Leu Phe Val Pro Ser Leu Asn Val Asp Gly Gln Pro Ile Phe Ala Asn 
145                 150                 155                 160 
Ile Thr Leu Pro Val Tyr Thr Leu Lys Glu Arg Cys Leu Gln Val Val 
                165                 170                 175     
Arg Ser Leu Val Lys Pro Glu Asn Tyr Arg Arg Leu Asp Ile Val Arg 
            180                 185                 190         
Ser Leu Tyr Glu Asp Leu Glu Asp His Pro Asn Val Gln Lys Asp Leu 
        195                 200                 205             
Glu Arg Leu Thr Gln Glu Arg Ile Ala His Gln Arg Met Gly Asp Leu 
    210                 215                 220                 
Glu Gly Gly Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr Lys Leu 
225                 230                 235                 240 
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala 
                245                 250                 255     
Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly 
            260                 265                 270         
His Trp Pro Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser Lys Ser 
        275                 280                 285             
Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr 
    290                 295                 300                 
Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile 
305                 310                 315                 320 
Ser Ile Asn Tyr Arg Thr 
                325     

<210> 153
<211> 336
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_VHL_Linker 2_aCS3

<400> 153
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Met Pro Arg Arg Ala Glu 
1               5                   10                  15      
Asn Trp Asp Glu Ala Glu Val Gly Ala Glu Glu Ala Gly Val Glu Glu 
            20                  25                  30          
Tyr Gly Pro Glu Glu Asp Gly Gly Glu Glu Ser Gly Ala Glu Glu Ser 
        35                  40                  45              
Gly Pro Glu Glu Ser Gly Pro Glu Glu Leu Gly Ala Glu Glu Glu Met 
    50                  55                  60                  
Glu Val Gly Arg Pro Arg Pro Val Leu Arg Ser Val Asn Ser Arg Glu 
65                  70                  75                  80  
Pro Ser Gln Val Ile Phe Cys Asn Arg Ser Pro Arg Val Val Leu Pro 
                85                  90                  95      
Val Trp Leu Asn Phe Asp Gly Glu Pro Gln Pro Tyr Pro Thr Leu Pro 
            100                 105                 110         
Pro Gly Thr Gly Arg Arg Ile His Ser Tyr Arg Gly His Leu Trp Leu 
        115                 120                 125             
Phe Arg Asp Ala Gly Thr His Asp Gly Leu Leu Val Asn Gln Thr Glu 
    130                 135                 140                 
Leu Phe Val Pro Ser Leu Asn Val Asp Gly Gln Pro Ile Phe Ala Asn 
145                 150                 155                 160 
Ile Thr Leu Pro Val Tyr Thr Leu Lys Glu Arg Cys Leu Gln Val Val 
                165                 170                 175     
Arg Ser Leu Val Lys Pro Glu Asn Tyr Arg Arg Leu Asp Ile Val Arg 
            180                 185                 190         
Ser Leu Tyr Glu Asp Leu Glu Asp His Pro Asn Val Gln Lys Asp Leu 
        195                 200                 205             
Glu Arg Leu Thr Gln Glu Arg Ile Ala His Gln Arg Met Gly Asp Leu 
    210                 215                 220                 
Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 
Ser Arg Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr 
                245                 250                 255     
Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp 
            260                 265                 270         
Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp 
        275                 280                 285             
Gln Glu Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly 
    290                 295                 300                 
Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr 
305                 310                 315                 320 
Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                325                 330                 335     



<210> 154
<211> 326
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_VHL_Linker 4_aCS3

<400> 154
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Met Pro Arg Arg Ala Glu 
1               5                   10                  15      
Asn Trp Asp Glu Ala Glu Val Gly Ala Glu Glu Ala Gly Val Glu Glu 
            20                  25                  30          
Tyr Gly Pro Glu Glu Asp Gly Gly Glu Glu Ser Gly Ala Glu Glu Ser 
        35                  40                  45              
Gly Pro Glu Glu Ser Gly Pro Glu Glu Leu Gly Ala Glu Glu Glu Met 
    50                  55                  60                  
Glu Val Gly Arg Pro Arg Pro Val Leu Arg Ser Val Asn Ser Arg Glu 
65                  70                  75                  80  
Pro Ser Gln Val Ile Phe Cys Asn Arg Ser Pro Arg Val Val Leu Pro 
                85                  90                  95      
Val Trp Leu Asn Phe Asp Gly Glu Pro Gln Pro Tyr Pro Thr Leu Pro 
            100                 105                 110         
Pro Gly Thr Gly Arg Arg Ile His Ser Tyr Arg Gly His Leu Trp Leu 
        115                 120                 125             
Phe Arg Asp Ala Gly Thr His Asp Gly Leu Leu Val Asn Gln Thr Glu 
    130                 135                 140                 
Leu Phe Val Pro Ser Leu Asn Val Asp Gly Gln Pro Ile Phe Ala Asn 
145                 150                 155                 160 
Ile Thr Leu Pro Val Tyr Thr Leu Lys Glu Arg Cys Leu Gln Val Val 
                165                 170                 175     
Arg Ser Leu Val Lys Pro Glu Asn Tyr Arg Arg Leu Asp Ile Val Arg 
            180                 185                 190         
Ser Leu Tyr Glu Asp Leu Glu Asp His Pro Asn Val Gln Lys Asp Leu 
        195                 200                 205             
Glu Arg Leu Thr Gln Glu Arg Ile Ala His Gln Arg Met Gly Asp Gly 
    210                 215                 220                 
Gly Gly Gly Gly Glu Phe Ala Met Val Ser Ser Val Pro Thr Lys Leu 
225                 230                 235                 240 
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala 
                245                 250                 255     
Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly 
            260                 265                 270         
His Trp Pro Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser Lys Ser 
        275                 280                 285             
Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr 
    290                 295                 300                 
Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile 
305                 310                 315                 320 
Ser Ile Asn Tyr Arg Thr 
                325     

<210> 155
<211> 336
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_VHL_Linker 2_aCS3(V33R)

<400> 155
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Met Pro Arg Arg Ala Glu 
1               5                   10                  15      
Asn Trp Asp Glu Ala Glu Val Gly Ala Glu Glu Ala Gly Val Glu Glu 
            20                  25                  30          
Tyr Gly Pro Glu Glu Asp Gly Gly Glu Glu Ser Gly Ala Glu Glu Ser 
        35                  40                  45              
Gly Pro Glu Glu Ser Gly Pro Glu Glu Leu Gly Ala Glu Glu Glu Met 
    50                  55                  60                  
Glu Val Gly Arg Pro Arg Pro Val Leu Arg Ser Val Asn Ser Arg Glu 
65                  70                  75                  80  
Pro Ser Gln Val Ile Phe Cys Asn Arg Ser Pro Arg Val Val Leu Pro 
                85                  90                  95      
Val Trp Leu Asn Phe Asp Gly Glu Pro Gln Pro Tyr Pro Thr Leu Pro 
            100                 105                 110         
Pro Gly Thr Gly Arg Arg Ile His Ser Tyr Arg Gly His Leu Trp Leu 
        115                 120                 125             
Phe Arg Asp Ala Gly Thr His Asp Gly Leu Leu Val Asn Gln Thr Glu 
    130                 135                 140                 
Leu Phe Val Pro Ser Leu Asn Val Asp Gly Gln Pro Ile Phe Ala Asn 
145                 150                 155                 160 
Ile Thr Leu Pro Val Tyr Thr Leu Lys Glu Arg Cys Leu Gln Val Val 
                165                 170                 175     
Arg Ser Leu Val Lys Pro Glu Asn Tyr Arg Arg Leu Asp Ile Val Arg 
            180                 185                 190         
Ser Leu Tyr Glu Asp Leu Glu Asp His Pro Asn Val Gln Lys Asp Leu 
        195                 200                 205             
Glu Arg Leu Thr Gln Glu Arg Ile Ala His Gln Arg Met Gly Asp Leu 
    210                 215                 220                 
Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 
Ser Arg Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr 
                245                 250                 255     
Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp 
            260                 265                 270         
Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp 
        275                 280                 285             
Gln Glu Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly 
    290                 295                 300                 
Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr 
305                 310                 315                 320 
Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                325                 330                 335     



<210> 156
<211> 273
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2B_Linker 2_aCS3

<400> 156
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Thr Pro Ala Arg Arg Arg 
1               5                   10                  15      
Leu Met Arg Asp Phe Lys Arg Leu Gln Glu Asp Pro Pro Val Gly Val 
            20                  25                  30          
Ser Gly Ala Pro Ser Glu Asn Asn Ile Met Gln Trp Asn Ala Val Ile 
        35                  40                  45              
Phe Gly Pro Glu Gly Thr Pro Phe Glu Asp Gly Thr Phe Lys Leu Val 
    50                  55                  60                  
Ile Glu Phe Ser Glu Glu Tyr Pro Asn Lys Pro Pro Thr Val Arg Phe 
65                  70                  75                  80  
Leu Ser Lys Met Phe His Pro Asn Val Tyr Ala Asp Gly Ser Ile Cys 
                85                  90                  95      
Leu Asp Ile Leu Gln Asn Arg Trp Ser Pro Thr Tyr Asp Val Ser Ser 
            100                 105                 110         
Ile Leu Thr Ser Ile Gln Ser Leu Leu Asp Glu Pro Asn Pro Asn Ser 
        115                 120                 125             
Pro Ala Asn Ser Gln Ala Ala Gln Leu Tyr Gln Glu Asn Lys Arg Glu 
    130                 135                 140                 
Tyr Glu Lys Arg Val Ser Ala Ile Val Glu Gln Ser Trp Asn Asp Ser 
145                 150                 155                 160 
Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     
Ser Ser Arg Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala 
            180                 185                 190         
Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val 
        195                 200                 205             
Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val 
    210                 215                 220                 
Trp Gln Glu Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser 
225                 230                 235                 240 
Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser 
                245                 250                 255     
Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg 
            260                 265                 270         
Thr 
    

<210> 157
<211> 300
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2C_Linker 2_aCS3

<400> 157
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Ser Gln Asn Arg Asp Pro 
1               5                   10                  15      
Ala Ala Thr Ser Val Ala Ala Ala Arg Lys Gly Ala Glu Pro Ser Gly 
            20                  25                  30          
Gly Ala Ala Arg Gly Pro Val Gly Lys Arg Leu Gln Gln Glu Leu Met 
        35                  40                  45              
Thr Leu Met Met Ser Gly Asp Lys Gly Ile Ser Ala Phe Pro Glu Ser 
    50                  55                  60                  
Asp Asn Leu Phe Lys Trp Val Gly Thr Ile His Gly Ala Ala Gly Thr 
65                  70                  75                  80  
Val Tyr Glu Asp Leu Arg Tyr Lys Leu Ser Leu Glu Phe Pro Ser Gly 
                85                  90                  95      
Tyr Pro Tyr Asn Ala Pro Thr Val Lys Phe Leu Thr Pro Cys Tyr His 
            100                 105                 110         
Pro Asn Val Asp Thr Gln Gly Asn Ile Cys Leu Asp Ile Leu Lys Glu 
        115                 120                 125             
Lys Trp Ser Ala Leu Tyr Asp Val Arg Thr Ile Leu Leu Ser Ile Gln 
    130                 135                 140                 
Ser Leu Leu Gly Glu Pro Asn Ile Asp Ser Pro Leu Asn Thr His Ala 
145                 150                 155                 160 
Ala Glu Leu Trp Lys Asn Pro Thr Ala Phe Lys Lys Tyr Leu Gln Glu 
                165                 170                 175     
Thr Tyr Ser Lys Gln Val Thr Ser Gln Glu Pro Leu Glu Gly Gly Gly 
            180                 185                 190         
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser 
        195                 200                 205             
Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
    210                 215                 220                 
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile 
225                 230                 235                 240 
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
                245                 250                 255     
Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
            260                 265                 270         
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
        275                 280                 285             
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
    290                 295                 300 

<210> 158
<211> 258
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2D1_Linker 1_aCS3

<400> 158
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Leu Lys Arg Ile Gln Lys 
1               5                   10                  15      
Glu Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly 
            20                  25                  30          
Pro Val Gly Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro 
        35                  40                  45              
Pro Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe 
    50                  55                  60                  
Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys 
65                  70                  75                  80  
Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile 
                85                  90                  95      
Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu 
            100                 105                 110         
Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val 
        115                 120                 125             
Pro Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg 
    130                 135                 140                 
His Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met Leu Glu Gly Gly Gly 
145                 150                 155                 160 
Gly Ser Ser Arg Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala 
                165                 170                 175     
Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr 
            180                 185                 190         
Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp 
        195                 200                 205             
Val Trp Gln Glu Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile 
    210                 215                 220                 
Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly 
225                 230                 235                 240 
Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr 
                245                 250                 255     
Arg Thr 
        

<210> 159
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2D1_Linker 2_aCS3

<400> 159
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Leu Lys Arg Ile Gln Lys 
1               5                   10                  15      
Glu Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly 
            20                  25                  30          
Pro Val Gly Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro 
        35                  40                  45              
Pro Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe 
    50                  55                  60                  
Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys 
65                  70                  75                  80  
Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile 
                85                  90                  95      
Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu 
            100                 105                 110         
Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val 
        115                 120                 125             
Pro Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg 
    130                 135                 140                 
His Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met Leu Glu Gly Gly Gly 
145                 150                 155                 160 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser 
                165                 170                 175     
Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
            180                 185                 190         
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile 
        195                 200                 205             
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
    210                 215                 220                 
Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
225                 230                 235                 240 
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
                245                 250                 255     
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
            260                 265             

<210> 160
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2D1_Linker 2_aCS3(V33R)

<400> 160
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Leu Lys Arg Ile Gln Lys 
1               5                   10                  15      
Glu Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly 
            20                  25                  30          
Pro Val Gly Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro 
        35                  40                  45              
Pro Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe 
    50                  55                  60                  
Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys 
65                  70                  75                  80  
Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile 
                85                  90                  95      
Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu 
            100                 105                 110         
Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val 
        115                 120                 125             
Pro Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg 
    130                 135                 140                 
His Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met Leu Glu Gly Gly Gly 
145                 150                 155                 160 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser 
                165                 170                 175     
Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
            180                 185                 190         
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Arg Ile 
        195                 200                 205             
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
    210                 215                 220                 
Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
225                 230                 235                 240 
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
                245                 250                 255     
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
            260                 265             

<210> 161
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2D1_Linker 2_aCS3 (K7Q)

<400> 161
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Leu Lys Arg Ile Gln Lys 
1               5                   10                  15      
Glu Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly 
            20                  25                  30          
Pro Val Gly Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro 
        35                  40                  45              
Pro Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe 
    50                  55                  60                  
Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys 
65                  70                  75                  80  
Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile 
                85                  90                  95      
Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu 
            100                 105                 110         
Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val 
        115                 120                 125             
Pro Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg 
    130                 135                 140                 
His Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met Leu Glu Gly Gly Gly 
145                 150                 155                 160 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser 
                165                 170                 175     
Ser Val Pro Thr Gln Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
            180                 185                 190         
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile 
        195                 200                 205             
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
    210                 215                 220                 
Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
225                 230                 235                 240 
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
                245                 250                 255     
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
            260                 265             

<210> 162
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2D1_Linker 2_aCS3 (K55Y)

<400> 162
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Leu Lys Arg Ile Gln Lys 
1               5                   10                  15      
Glu Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly 
            20                  25                  30          
Pro Val Gly Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro 
        35                  40                  45              
Pro Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe 
    50                  55                  60                  
Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys 
65                  70                  75                  80  
Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile 
                85                  90                  95      
Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu 
            100                 105                 110         
Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val 
        115                 120                 125             
Pro Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg 
    130                 135                 140                 
His Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met Leu Glu Gly Gly Gly 
145                 150                 155                 160 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser 
                165                 170                 175     
Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
            180                 185                 190         
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile 
        195                 200                 205             
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
    210                 215                 220                 
Val Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
225                 230                 235                 240 
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
                245                 250                 255     
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
            260                 265             

<210> 163
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2D1_Linker 2_aCS3 (K64H)

<400> 163
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Leu Lys Arg Ile Gln Lys 
1               5                   10                  15      
Glu Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly 
            20                  25                  30          
Pro Val Gly Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro 
        35                  40                  45              
Pro Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe 
    50                  55                  60                  
Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys 
65                  70                  75                  80  
Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile 
                85                  90                  95      
Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu 
            100                 105                 110         
Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val 
        115                 120                 125             
Pro Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg 
    130                 135                 140                 
His Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met Leu Glu Gly Gly Gly 
145                 150                 155                 160 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser 
                165                 170                 175     
Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
            180                 185                 190         
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile 
        195                 200                 205             
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
    210                 215                 220                 
Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu His Pro Gly 
225                 230                 235                 240 
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
                245                 250                 255     
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
            260                 265             

<210> 164
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2D1_Linker 2_aCS3 (K7Q, K55Y)

<400> 164
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Leu Lys Arg Ile Gln Lys 
1               5                   10                  15      
Glu Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly 
            20                  25                  30          
Pro Val Gly Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro 
        35                  40                  45              
Pro Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe 
    50                  55                  60                  
Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys 
65                  70                  75                  80  
Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile 
                85                  90                  95      
Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu 
            100                 105                 110         
Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val 
        115                 120                 125             
Pro Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg 
    130                 135                 140                 
His Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met Leu Glu Gly Gly Gly 
145                 150                 155                 160 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser 
                165                 170                 175     
Ser Val Pro Thr Gln Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
            180                 185                 190         
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile 
        195                 200                 205             
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
    210                 215                 220                 
Val Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
225                 230                 235                 240 
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
                245                 250                 255     
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
            260                 265             

<210> 165
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2D1_Linker 2_aCS3 (K7Q, K64H)

<400> 165
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Leu Lys Arg Ile Gln Lys 
1               5                   10                  15      
Glu Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly 
            20                  25                  30          
Pro Val Gly Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro 
        35                  40                  45              
Pro Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe 
    50                  55                  60                  
Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys 
65                  70                  75                  80  
Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile 
                85                  90                  95      
Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu 
            100                 105                 110         
Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val 
        115                 120                 125             
Pro Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg 
    130                 135                 140                 
His Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met Leu Glu Gly Gly Gly 
145                 150                 155                 160 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser 
                165                 170                 175     
Ser Val Pro Thr Gln Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
            180                 185                 190         
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile 
        195                 200                 205             
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
    210                 215                 220                 
Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu His Pro Gly 
225                 230                 235                 240 
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
                245                 250                 255     
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
            260                 265             

<210> 166
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2D1_Linker 2_aCS3 (K55Y, K64H)

<400> 166
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Leu Lys Arg Ile Gln Lys 
1               5                   10                  15      
Glu Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly 
            20                  25                  30          
Pro Val Gly Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro 
        35                  40                  45              
Pro Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe 
    50                  55                  60                  
Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys 
65                  70                  75                  80  
Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile 
                85                  90                  95      
Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu 
            100                 105                 110         
Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val 
        115                 120                 125             
Pro Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg 
    130                 135                 140                 
His Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met Leu Glu Gly Gly Gly 
145                 150                 155                 160 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser 
                165                 170                 175     
Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
            180                 185                 190         
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile 
        195                 200                 205             
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
    210                 215                 220                 
Val Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu His Pro Gly 
225                 230                 235                 240 
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
                245                 250                 255     
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
            260                 265             

<210> 167
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2D1_Linker 2_aCS3 (K7Q, K55Y, K64H)

<400> 167
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Leu Lys Arg Ile Gln Lys 
1               5                   10                  15      
Glu Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly 
            20                  25                  30          
Pro Val Gly Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro 
        35                  40                  45              
Pro Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe 
    50                  55                  60                  
Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys 
65                  70                  75                  80  
Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile 
                85                  90                  95      
Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu 
            100                 105                 110         
Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val 
        115                 120                 125             
Pro Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg 
    130                 135                 140                 
His Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met Leu Glu Gly Gly Gly 
145                 150                 155                 160 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser 
                165                 170                 175     
Ser Val Pro Thr Gln Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
            180                 185                 190         
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile 
        195                 200                 205             
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
    210                 215                 220                 
Val Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu His Pro Gly 
225                 230                 235                 240 
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
                245                 250                 255     
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
            260                 265             

<210> 168
<211> 223
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_VHL control

<400> 168
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Met Pro Arg Arg Ala Glu 
1               5                   10                  15      
Asn Trp Asp Glu Ala Glu Val Gly Ala Glu Glu Ala Gly Val Glu Glu 
            20                  25                  30          
Tyr Gly Pro Glu Glu Asp Gly Gly Glu Glu Ser Gly Ala Glu Glu Ser 
        35                  40                  45              
Gly Pro Glu Glu Ser Gly Pro Glu Glu Leu Gly Ala Glu Glu Glu Met 
    50                  55                  60                  
Glu Val Gly Arg Pro Arg Pro Val Leu Arg Ser Val Asn Ser Arg Glu 
65                  70                  75                  80  
Pro Ser Gln Val Ile Phe Cys Asn Arg Ser Pro Arg Val Val Leu Pro 
                85                  90                  95      
Val Trp Leu Asn Phe Asp Gly Glu Pro Gln Pro Tyr Pro Thr Leu Pro 
            100                 105                 110         
Pro Gly Thr Gly Arg Arg Ile His Ser Tyr Arg Gly His Leu Trp Leu 
        115                 120                 125             
Phe Arg Asp Ala Gly Thr His Asp Gly Leu Leu Val Asn Gln Thr Glu 
    130                 135                 140                 
Leu Phe Val Pro Ser Leu Asn Val Asp Gly Gln Pro Ile Phe Ala Asn 
145                 150                 155                 160 
Ile Thr Leu Pro Val Tyr Thr Leu Lys Glu Arg Cys Leu Gln Val Val 
                165                 170                 175     
Arg Ser Leu Val Lys Pro Glu Asn Tyr Arg Arg Leu Asp Ile Val Arg 
            180                 185                 190         
Ser Leu Tyr Glu Asp Leu Glu Asp His Pro Asn Val Gln Lys Asp Leu 
        195                 200                 205             
Glu Arg Leu Thr Gln Glu Arg Ile Ala His Gln Arg Met Gly Asp 
    210                 215                 220             

<210> 169
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2D1 control

<400> 169
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Leu Lys Arg Ile Gln Lys 
1               5                   10                  15      
Glu Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly 
            20                  25                  30          
Pro Val Gly Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro 
        35                  40                  45              
Pro Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe 
    50                  55                  60                  
Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys 
65                  70                  75                  80  
Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile 
                85                  90                  95      
Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu 
            100                 105                 110         
Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val 
        115                 120                 125             
Pro Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg 
    130                 135                 140                 
His Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met 
145                 150                 155 

<210> 170
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2D1(C85A)_Linker 2_aCS3

<400> 170
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Leu Lys Arg Ile Gln Lys 
1               5                   10                  15      
Glu Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly 
            20                  25                  30          
Pro Val Gly Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro 
        35                  40                  45              
Pro Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe 
    50                  55                  60                  
Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys 
65                  70                  75                  80  
Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Ala Leu Asp Ile 
                85                  90                  95      
Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu 
            100                 105                 110         
Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val 
        115                 120                 125             
Pro Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg 
    130                 135                 140                 
His Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met Leu Glu Gly Gly Gly 
145                 150                 155                 160 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser 
                165                 170                 175     
Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
            180                 185                 190         
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile 
        195                 200                 205             
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
    210                 215                 220                 
Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
225                 230                 235                 240 
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
                245                 250                 255     
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
            260                 265             

<210> 171
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2D2_Linker 2_aCS3

<400> 171
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Leu Lys Arg Ile His Lys 
1               5                   10                  15      
Glu Leu Asn Asp Leu Ala Arg Asp Pro Pro Ala Gln Cys Ser Ala Gly 
            20                  25                  30          
Pro Val Gly Asp Asp Met Phe His Trp Gln Ala Thr Ile Met Gly Pro 
        35                  40                  45              
Asn Asp Ser Pro Tyr Gln Gly Gly Val Phe Phe Leu Thr Ile His Phe 
    50                  55                  60                  
Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Val Ala Phe Thr Thr Arg 
65                  70                  75                  80  
Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile 
                85                  90                  95      
Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Ile Ser Lys Val Leu Leu 
            100                 105                 110         
Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val 
        115                 120                 125             
Pro Glu Ile Ala Arg Ile Tyr Lys Thr Asp Arg Glu Lys Tyr Asn Arg 
    130                 135                 140                 
Ile Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met Leu Glu Gly Gly Gly 
145                 150                 155                 160 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser 
                165                 170                 175     
Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
            180                 185                 190         
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile 
        195                 200                 205             
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
    210                 215                 220                 
Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
225                 230                 235                 240 
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
                245                 250                 255     
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
            260                 265             

<210> 172
<211> 268
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2D3_Linker 2_aCS3

<400> 172
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Leu Lys Arg Ile Asn Lys 
1               5                   10                  15      
Glu Leu Ser Asp Leu Ala Arg Asp Pro Pro Ala Gln Cys Ser Ala Gly 
            20                  25                  30          
Pro Val Gly Asp Asp Met Phe His Trp Gln Ala Thr Ile Met Gly Pro 
        35                  40                  45              
Asn Asp Ser Pro Tyr Gln Gly Gly Val Phe Phe Leu Thr Ile His Phe 
    50                  55                  60                  
Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Val Ala Phe Thr Thr Arg 
65                  70                  75                  80  
Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile 
                85                  90                  95      
Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Ile Ser Lys Val Leu Leu 
            100                 105                 110         
Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val 
        115                 120                 125             
Pro Glu Ile Ala Arg Ile Tyr Lys Thr Asp Arg Asp Lys Tyr Asn Arg 
    130                 135                 140                 
Ile Ser Arg Glu Trp Thr Gln Lys Tyr Ala Met Leu Glu Gly Gly Gly 
145                 150                 155                 160 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser 
                165                 170                 175     
Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
            180                 185                 190         
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile 
        195                 200                 205             
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
    210                 215                 220                 
Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
225                 230                 235                 240 
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
                245                 250                 255     
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
            260                 265             

<210> 173
<211> 314
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2E1_Linker 2_aCS3

<400> 173
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Asp Asp Asp Ser Arg Ala 
1               5                   10                  15      
Ser Thr Ser Ser Ser Ser Ser Ser Ser Ser Asn Gln Gln Thr Glu Lys 
            20                  25                  30          
Glu Thr Asn Thr Pro Lys Lys Lys Glu Ser Lys Val Ser Met Ser Lys 
        35                  40                  45              
Asn Ser Lys Leu Leu Ser Thr Ser Ala Lys Arg Ile Gln Lys Glu Leu 
    50                  55                  60                  
Ala Asp Ile Thr Leu Asp Pro Pro Pro Asn Cys Ser Ala Gly Pro Lys 
65                  70                  75                  80  
Gly Asp Asn Ile Tyr Glu Trp Arg Ser Thr Ile Leu Gly Pro Pro Gly 
                85                  90                  95      
Ser Val Tyr Glu Gly Gly Val Phe Phe Leu Asp Ile Thr Phe Thr Pro 
            100                 105                 110         
Glu Tyr Pro Phe Lys Pro Pro Lys Val Thr Phe Arg Thr Arg Ile Tyr 
        115                 120                 125             
His Cys Asn Ile Asn Ser Gln Gly Val Ile Cys Leu Asp Ile Leu Lys 
    130                 135                 140                 
Asp Asn Trp Ser Pro Ala Leu Thr Ile Ser Lys Val Leu Leu Ser Ile 
145                 150                 155                 160 
Cys Ser Leu Leu Thr Asp Cys Asn Pro Ala Asp Pro Leu Val Gly Ser 
                165                 170                 175     
Ile Ala Thr Gln Tyr Met Thr Asn Arg Ala Glu His Asp Arg Met Ala 
            180                 185                 190         
Arg Gln Trp Thr Lys Arg Tyr Ala Thr Leu Glu Gly Gly Gly Gly Ser 
        195                 200                 205             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser Ser Val 
    210                 215                 220                 
Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile 
225                 230                 235                 240 
Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr Tyr 
                245                 250                 255     
Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val Pro 
            260                 265                 270         
Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp 
        275                 280                 285             
Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr 
    290                 295                 300                 
Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
305                 310                 

<210> 174
<211> 282
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2F_Linker 2_aCS3

<400> 174
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Thr Arg Arg Val Ser Val 
1               5                   10                  15      
Arg Asp Lys Leu Leu Val Lys Glu Val Ala Glu Leu Glu Ala Asn Leu 
            20                  25                  30          
Pro Cys Thr Cys Lys Val His Phe Pro Asp Pro Asn Lys Leu His Cys 
        35                  40                  45              
Phe Gln Leu Thr Val Thr Pro Asp Glu Gly Tyr Tyr Gln Gly Gly Lys 
    50                  55                  60                  
Phe Gln Phe Glu Thr Glu Val Pro Asp Ala Tyr Asn Met Val Pro Pro 
65                  70                  75                  80  
Lys Val Lys Cys Leu Thr Lys Ile Trp His Pro Asn Ile Thr Glu Thr 
                85                  90                  95      
Gly Glu Ile Cys Leu Ser Leu Leu Arg Glu His Ser Ile Asp Gly Thr 
            100                 105                 110         
Gly Trp Ala Pro Thr Arg Thr Leu Lys Asp Val Val Trp Gly Leu Asn 
        115                 120                 125             
Ser Leu Phe Thr Asp Leu Leu Asn Phe Asp Asp Pro Leu Asn Ile Glu 
    130                 135                 140                 
Ala Ala Glu His His Leu Arg Asp Lys Glu Asp Phe Arg Asn Lys Val 
145                 150                 155                 160 
Asp Asp Tyr Ile Lys Arg Tyr Ala Arg Leu Glu Gly Gly Gly Gly Ser 
                165                 170                 175     
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser Ser Val 
            180                 185                 190         
Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile 
        195                 200                 205             
Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr Tyr 
    210                 215                 220                 
Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val Pro 
225                 230                 235                 240 
Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp 
                245                 250                 255     
Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr 
            260                 265                 270         
Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
        275                 280         

<210> 175
<211> 275
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2G1_Linker 2_aCS3

<400> 175
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Leu Leu Leu Arg Arg Gln Leu 
1               5                   10                  15      
Ala Glu Leu Asn Lys Asn Pro Val Glu Gly Phe Ser Ala Gly Leu Ile 
            20                  25                  30          
Asp Asp Asn Asp Leu Tyr Arg Trp Glu Val Leu Ile Ile Gly Pro Pro 
        35                  40                  45              
Asp Thr Leu Tyr Glu Gly Gly Val Phe Lys Ala His Leu Thr Phe Pro 
    50                  55                  60                  
Lys Asp Tyr Pro Leu Arg Pro Pro Lys Met Lys Phe Ile Thr Glu Ile 
65                  70                  75                  80  
Trp His Pro Asn Val Asp Lys Asn Gly Asp Val Cys Ile Ser Ile Leu 
                85                  90                  95      
His Glu Pro Gly Glu Asp Lys Tyr Gly Tyr Glu Lys Pro Glu Glu Arg 
            100                 105                 110         
Trp Leu Pro Ile His Thr Val Glu Thr Ile Met Ile Ser Val Ile Ser 
        115                 120                 125             
Met Leu Ala Asp Pro Asn Gly Asp Ser Pro Ala Asn Val Asp Ala Ala 
    130                 135                 140                 
Lys Glu Trp Arg Glu Asp Arg Asn Gly Glu Phe Lys Arg Lys Val Ala 
145                 150                 155                 160 
Arg Cys Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     
Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr Lys Leu Glu Val Val 
            180                 185                 190         
Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val 
        195                 200                 205             
Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro 
    210                 215                 220                 
Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr 
225                 230                 235                 240 
Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala 
                245                 250                 255     
Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn 
            260                 265                 270         
Tyr Arg Thr 
        275 

<210> 176
<211> 286
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2G2_Linker 2_aCS3

<400> 176
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Gly Thr Ala Leu Lys Arg 
1               5                   10                  15      
Leu Met Ala Glu Tyr Lys Gln Leu Thr Leu Asn Pro Pro Glu Gly Ile 
            20                  25                  30          
Val Ala Gly Pro Met Asn Glu Glu Asn Phe Phe Glu Trp Glu Ala Leu 
        35                  40                  45              
Ile Met Gly Pro Glu Asp Thr Cys Phe Glu Phe Gly Val Phe Pro Ala 
    50                  55                  60                  
Ile Leu Ser Phe Pro Leu Asp Tyr Pro Leu Ser Pro Pro Lys Met Arg 
65                  70                  75                  80  
Phe Thr Cys Glu Met Phe His Pro Asn Ile Tyr Pro Asp Gly Arg Val 
                85                  90                  95      
Cys Ile Ser Ile Leu His Ala Pro Gly Asp Asp Pro Met Gly Tyr Glu 
            100                 105                 110         
Ser Ser Ala Glu Arg Trp Ser Pro Val Gln Ser Val Glu Lys Ile Leu 
        115                 120                 125             
Leu Ser Val Val Ser Met Leu Ala Glu Pro Asn Asp Glu Ser Gly Ala 
    130                 135                 140                 
Asn Val Asp Ala Ser Lys Met Trp Arg Asp Asp Arg Glu Gln Phe Tyr 
145                 150                 155                 160 
Lys Ile Ala Lys Gln Ile Val Gln Lys Ser Leu Gly Leu Leu Glu Gly 
                165                 170                 175     
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg 
            180                 185                 190         
Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr 
        195                 200                 205             
Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr 
    210                 215                 220                 
Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu 
225                 230                 235                 240 
Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys 
                245                 250                 255     
Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser 
            260                 265                 270         
Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
        275                 280                 285     

<210> 177
<211> 281
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2H_Linker 2_aCS3

<400> 177
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Ser Pro Ser Pro Gly Lys 
1               5                   10                  15      
Arg Arg Met Asp Thr Asp Val Val Lys Leu Ile Glu Ser Lys His Glu 
            20                  25                  30          
Val Thr Ile Leu Gly Gly Leu Asn Glu Phe Val Val Lys Phe Tyr Gly 
        35                  40                  45              
Pro Gln Gly Thr Pro Tyr Glu Gly Gly Val Trp Lys Val Arg Val Asp 
    50                  55                  60                  
Leu Pro Asp Lys Tyr Pro Phe Lys Ser Pro Ser Ile Gly Phe Met Asn 
65                  70                  75                  80  
Lys Ile Phe His Pro Asn Ile Asp Glu Ala Ser Gly Thr Val Cys Leu 
                85                  90                  95      
Asp Val Ile Asn Gln Thr Trp Thr Ala Leu Tyr Asp Leu Thr Asn Ile 
            100                 105                 110         
Phe Glu Ser Phe Leu Pro Gln Leu Leu Ala Tyr Pro Asn Pro Ile Asp 
        115                 120                 125             
Pro Leu Asn Gly Asp Ala Ala Ala Met Tyr Leu His Arg Pro Glu Glu 
    130                 135                 140                 
Tyr Lys Gln Lys Ile Lys Glu Tyr Ile Gln Lys Tyr Ala Thr Glu Glu 
145                 150                 155                 160 
Ala Leu Lys Glu Gln Glu Glu Gly Leu Glu Gly Gly Gly Gly Ser Gly 
                165                 170                 175     
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser Ser Val Pro 
            180                 185                 190         
Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser 
        195                 200                 205             
Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly 
    210                 215                 220                 
Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val Pro Gly 
225                 230                 235                 240 
Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr 
                245                 250                 255     
Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly 
            260                 265                 270         
Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
        275                 280     

<210> 178
<211> 279
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2I_Linker 2_aCS3

<400> 178
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Gly Ile Ala Leu Ser Arg 
1               5                   10                  15      
Leu Ala Gln Glu Arg Lys Ala Trp Arg Lys Asp His Pro Phe Gly Phe 
            20                  25                  30          
Val Ala Val Pro Thr Lys Asn Pro Asp Gly Thr Met Asn Leu Met Asn 
        35                  40                  45              
Trp Glu Cys Ala Ile Pro Gly Lys Lys Gly Thr Pro Trp Glu Gly Gly 
    50                  55                  60                  
Leu Phe Lys Leu Arg Met Leu Phe Lys Asp Asp Tyr Pro Ser Ser Pro 
65                  70                  75                  80  
Pro Lys Cys Lys Phe Glu Pro Pro Leu Phe His Pro Asn Val Tyr Pro 
                85                  90                  95      
Ser Gly Thr Val Cys Leu Ser Ile Leu Glu Glu Asp Lys Asp Trp Arg 
            100                 105                 110         
Pro Ala Ile Thr Ile Lys Gln Ile Leu Leu Gly Ile Gln Glu Leu Leu 
        115                 120                 125             
Asn Glu Pro Asn Ile Gln Asp Pro Ala Gln Ala Glu Ala Tyr Thr Ile 
    130                 135                 140                 
Tyr Cys Gln Asn Arg Val Glu Tyr Glu Lys Arg Val Arg Ala Gln Ala 
145                 150                 155                 160 
Lys Lys Phe Ala Pro Ser Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     
Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr Lys 
            180                 185                 190         
Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp 
        195                 200                 205             
Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr 
    210                 215                 220                 
Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser Lys 
225                 230                 235                 240 
Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile 
                245                 250                 255     
Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro 
            260                 265                 270         
Ile Ser Ile Asn Tyr Arg Thr 
        275                 

<210> 179
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2J2_Linker 2_aCS3

<400> 179
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Ser Thr Ser Ser Lys Arg 
1               5                   10                  15      
Ala Pro Thr Thr Ala Thr Gln Arg Leu Lys Gln Asp Tyr Leu Arg Ile 
            20                  25                  30          
Lys Lys Asp Pro Val Pro Tyr Ile Cys Ala Glu Pro Leu Pro Ser Asn 
        35                  40                  45              
Ile Leu Glu Trp His Tyr Val Val Arg Gly Pro Glu Met Thr Pro Tyr 
    50                  55                  60                  
Glu Gly Gly Tyr Tyr His Gly Lys Leu Ile Phe Pro Arg Glu Phe Pro 
65                  70                  75                  80  
Phe Lys Pro Pro Ser Ile Tyr Met Ile Thr Pro Asn Gly Arg Phe Lys 
                85                  90                  95      
Cys Asn Thr Arg Leu Cys Leu Ser Ile Thr Asp Phe His Pro Asp Thr 
            100                 105                 110         
Trp Asn Pro Ala Trp Ser Val Ser Thr Ile Leu Thr Gly Leu Leu Ser 
        115                 120                 125             
Phe Met Val Glu Lys Gly Pro Thr Leu Gly Ser Ile Glu Thr Ser Asp 
    130                 135                 140                 
Phe Thr Lys Arg Gln Leu Ala Val Gln Ser Leu Ala Phe Asn Leu Lys 
145                 150                 155                 160 
Asp Lys Val Phe Cys Glu Leu Phe Pro Glu Val Val Glu Glu Ile Lys 
                165                 170                 175     
Gln Lys Gln Lys Ala Gln Asp Glu Leu Ser Ser Arg Pro Gln Thr Leu 
            180                 185                 190         
Pro Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        195                 200                 205             
Gly Ser Ser Arg Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala 
    210                 215                 220                 
Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr 
225                 230                 235                 240 
Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp 
                245                 250                 255     
Val Trp Gln Glu Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile 
            260                 265                 270         
Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly 
        275                 280                 285             
Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr 
    290                 295                 300                 
Arg Thr 
305     

<210> 180
<211> 321
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2K_Linker 2_aCS3

<400> 180
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Asn Ile Ala Val Gln Arg 
1               5                   10                  15      
Ile Lys Arg Glu Phe Lys Glu Val Leu Lys Ser Glu Glu Thr Ser Lys 
            20                  25                  30          
Asn Gln Ile Lys Val Asp Leu Val Asp Glu Asn Phe Thr Glu Leu Arg 
        35                  40                  45              
Gly Glu Ile Ala Gly Pro Pro Asp Thr Pro Tyr Glu Gly Gly Arg Tyr 
    50                  55                  60                  
Gln Leu Glu Ile Lys Ile Pro Glu Thr Tyr Pro Phe Asn Pro Pro Lys 
65                  70                  75                  80  
Val Arg Phe Ile Thr Lys Ile Trp His Pro Asn Ile Ser Ser Val Thr 
                85                  90                  95      
Gly Ala Ile Cys Leu Asp Ile Leu Lys Asp Gln Trp Ala Ala Ala Met 
            100                 105                 110         
Thr Leu Arg Thr Val Leu Leu Ser Leu Gln Ala Leu Leu Ala Ala Ala 
        115                 120                 125             
Glu Pro Asp Asp Pro Gln Asp Ala Val Val Ala Asn Gln Tyr Lys Gln 
    130                 135                 140                 
Asn Pro Glu Met Phe Lys Gln Thr Ala Arg Leu Trp Ala His Val Tyr 
145                 150                 155                 160 
Ala Gly Ala Pro Val Ser Ser Pro Glu Tyr Thr Lys Lys Ile Glu Asn 
                165                 170                 175     
Leu Cys Ala Met Gly Phe Asp Arg Asn Ala Val Ile Val Ala Leu Ser 
            180                 185                 190         
Ser Lys Ser Trp Asp Val Glu Thr Ala Thr Glu Leu Leu Leu Ser Asn 
        195                 200                 205             
Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 
Ser Ser Arg Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala 
225                 230                 235                 240 
Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val 
                245                 250                 255     
Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val 
            260                 265                 270         
Trp Gln Glu Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser 
        275                 280                 285             
Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser 
    290                 295                 300                 
Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg 
305                 310                 315                 320 
Thr 
    

<210> 181
<211> 275
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2L3_Linker 2_aCS3

<400> 181
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Ala Ser Arg Arg Leu Met 
1               5                   10                  15      
Lys Glu Leu Glu Glu Ile Arg Lys Cys Gly Met Lys Asn Phe Arg Asn 
            20                  25                  30          
Ile Gln Val Asp Glu Ala Asn Leu Leu Thr Trp Gln Gly Leu Ile Val 
        35                  40                  45              
Pro Asp Asn Pro Pro Tyr Asp Lys Gly Ala Phe Arg Ile Glu Ile Asn 
    50                  55                  60                  
Phe Pro Ala Glu Tyr Pro Phe Lys Pro Pro Lys Ile Thr Phe Lys Thr 
65                  70                  75                  80  
Lys Ile Tyr His Pro Asn Ile Asp Glu Lys Gly Gln Val Cys Leu Pro 
                85                  90                  95      
Val Ile Ser Ala Glu Asn Trp Lys Pro Ala Thr Lys Thr Asp Gln Val 
            100                 105                 110         
Ile Gln Ser Leu Ile Ala Leu Val Asn Asp Pro Gln Pro Glu His Pro 
        115                 120                 125             
Leu Arg Ala Asp Leu Ala Glu Glu Tyr Ser Lys Asp Arg Lys Lys Phe 
    130                 135                 140                 
Cys Lys Asn Ala Glu Glu Phe Thr Lys Lys Tyr Gly Glu Lys Arg Pro 
145                 150                 155                 160 
Val Asp Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     
Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr Lys Leu Glu Val Val 
            180                 185                 190         
Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val 
        195                 200                 205             
Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro 
    210                 215                 220                 
Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr 
225                 230                 235                 240 
Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala 
                245                 250                 255     
Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn 
            260                 265                 270         
Tyr Arg Thr 
        275 

<210> 182
<211> 274
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2L6_Linker 2_aCS3

<400> 182
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Met Ala Ser Met Arg Val Val 
1               5                   10                  15      
Lys Glu Leu Glu Asp Leu Gln Lys Lys Pro Pro Pro Tyr Leu Arg Asn 
            20                  25                  30          
Leu Ser Ser Asp Asp Ala Asn Val Leu Val Trp His Ala Leu Leu Leu 
        35                  40                  45              
Pro Asp Gln Pro Pro Tyr His Leu Lys Ala Phe Asn Leu Arg Ile Ser 
    50                  55                  60                  
Phe Pro Pro Glu Tyr Pro Phe Lys Pro Pro Met Ile Lys Phe Thr Thr 
65                  70                  75                  80  
Lys Ile Tyr His Pro Asn Val Asp Glu Asn Gly Gln Ile Cys Leu Pro 
                85                  90                  95      
Ile Ile Ser Ser Glu Asn Trp Lys Pro Cys Thr Lys Thr Cys Gln Val 
            100                 105                 110         
Leu Glu Ala Leu Asn Val Leu Val Asn Arg Pro Asn Ile Arg Glu Pro 
        115                 120                 125             
Leu Arg Met Asp Leu Ala Asp Leu Leu Thr Gln Asn Pro Glu Leu Phe 
    130                 135                 140                 
Arg Lys Asn Ala Glu Glu Phe Thr Leu Arg Phe Gly Val Asp Arg Pro 
145                 150                 155                 160 
Ser Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     
Gly Ser Ser Arg Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala 
            180                 185                 190         
Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr 
        195                 200                 205             
Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp 
    210                 215                 220                 
Val Trp Gln Glu Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile 
225                 230                 235                 240 
Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly 
                245                 250                 255     
Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr 
            260                 265                 270         
Arg Thr 
        

<210> 183
<211> 279
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2M_Linker 2_aCS3

<400> 183
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Ser Ala Ala Gln Leu Arg 
1               5                   10                  15      
Ile Gln Lys Asp Ile Asn Glu Leu Asn Leu Pro Lys Thr Cys Asp Ile 
            20                  25                  30          
Ser Phe Ser Asp Pro Asp Asp Leu Leu Asn Phe Lys Leu Val Ile Cys 
        35                  40                  45              
Pro Asp Glu Gly Phe Tyr Lys Ser Gly Lys Phe Val Phe Ser Phe Lys 
    50                  55                  60                  
Val Gly Gln Gly Tyr Pro His Asp Pro Pro Lys Val Lys Cys Glu Thr 
65                  70                  75                  80  
Met Val Tyr His Pro Asn Ile Asp Leu Glu Gly Asn Val Cys Leu Asn 
                85                  90                  95      
Ile Leu Arg Glu Asp Trp Lys Pro Val Leu Thr Ile Asn Ser Ile Ile 
            100                 105                 110         
Tyr Gly Leu Gln Tyr Leu Phe Leu Glu Pro Asn Pro Glu Asp Pro Leu 
        115                 120                 125             
Asn Lys Glu Ala Ala Glu Val Leu Gln Asn Asn Arg Arg Leu Phe Glu 
    130                 135                 140                 
Gln Asn Val Gln Arg Ser Met Arg Gly Gly Tyr Ile Gly Ser Thr Tyr 
145                 150                 155                 160 
Phe Glu Arg Cys Leu Lys Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     
Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr Lys 
            180                 185                 190         
Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp 
        195                 200                 205             
Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr 
    210                 215                 220                 
Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser Lys 
225                 230                 235                 240 
Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile 
                245                 250                 255     
Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro 
            260                 265                 270         
Ile Ser Ile Asn Tyr Arg Thr 
        275                 

<210> 184
<211> 260
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2O_Linker 2_aCS3

<400> 184
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Asn His Ser Phe Lys Lys 
1               5                   10                  15      
Ile Glu Phe Gln Pro Pro Glu Ala Lys Lys Phe Phe Ser Thr Val Arg 
            20                  25                  30          
Lys Glu Met Ala Leu Leu Ala Thr Ser Leu Pro Glu Gly Ile Met Val 
        35                  40                  45              
Lys Thr Phe Glu Asp Arg Met Asp Leu Phe Ser Ala Leu Ile Lys Gly 
    50                  55                  60                  
Pro Thr Arg Thr Pro Tyr Glu Asp Gly Leu Tyr Leu Phe Asp Ile Gln 
65                  70                  75                  80  
Leu Pro Asn Ile Tyr Pro Ala Val Pro Pro His Phe Cys Tyr Leu Ser 
                85                  90                  95      
Gln Cys Ser Gly Arg Leu Asn Pro Asn Leu Tyr Asp Asn Gly Lys Val 
            100                 105                 110         
Cys Val Ser Leu Leu Gly Thr Trp Ile Gly Lys Gly Thr Glu Arg Trp 
        115                 120                 125             
Thr Ser Lys Ser Ser Leu Leu Gln Val Leu Ile Ser Ile Gln Gly Leu 
    130                 135                 140                 
Ile Leu Val Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 
Gly Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr Lys Leu Glu Val 
                165                 170                 175     
Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala 
            180                 185                 190         
Val Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp 
        195                 200                 205             
Pro Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser Lys Ser Thr Ala 
    210                 215                 220                 
Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
225                 230                 235                 240 
Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile 
                245                 250                 255     
Asn Tyr Arg Thr 
            260 

<210> 185
<211> 290
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2Q1_Linker 2_aCS3

<400> 185
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Gly Ser Val Gln Ala Thr 
1               5                   10                  15      
Asp Arg Leu Met Lys Glu Leu Arg Asp Ile Tyr Arg Ser Gln Ser Phe 
            20                  25                  30          
Lys Gly Gly Asn Tyr Ala Val Glu Leu Val Asn Asp Ser Leu Tyr Asp 
        35                  40                  45              
Trp Asn Val Lys Leu Leu Lys Val Asp Gln Asp Ser Ala Leu His Asn 
    50                  55                  60                  
Asp Leu Gln Ile Leu Lys Glu Lys Glu Gly Ala Asp Phe Ile Leu Leu 
65                  70                  75                  80  
Asn Phe Ser Phe Lys Asp Asn Phe Pro Phe Asp Pro Pro Phe Val Arg 
                85                  90                  95      
Val Val Ser Pro Val Leu Ser Gly Gly Tyr Val Leu Gly Gly Gly Ala 
            100                 105                 110         
Ile Cys Met Glu Leu Leu Thr Lys Gln Gly Trp Ser Ser Ala Tyr Ser 
        115                 120                 125             
Ile Glu Ser Val Ile Met Gln Ile Ser Ala Thr Leu Val Lys Gly Lys 
    130                 135                 140                 
Ala Arg Val Gln Phe Gly Ala Asn Lys Ser Gln Tyr Ser Leu Thr Arg 
145                 150                 155                 160 
Ala Gln Gln Ser Tyr Lys Ser Leu Val Gln Ile His Glu Lys Asn Gly 
                165                 170                 175     
Trp Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         
Gly Ser Ser Arg Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala 
        195                 200                 205             
Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr 
    210                 215                 220                 
Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp 
225                 230                 235                 240 
Val Trp Gln Glu Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile 
                245                 250                 255     
Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly 
            260                 265                 270         
Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr 
        275                 280                 285             
Arg Thr 
    290 

<210> 186
<211> 289
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2Q2_Linker 2_aCS3

<400> 186
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ala Val Ser Gly Ser Val 
1               5                   10                  15      
Gln Ala Ser Asp Arg Leu Met Lys Glu Leu Arg Asp Ile Tyr Arg Ser 
            20                  25                  30          
Gln Ser Tyr Lys Thr Gly Ile Tyr Ser Val Glu Leu Ile Asn Asp Ser 
        35                  40                  45              
Leu Tyr Asp Trp His Val Lys Leu Gln Lys Val Asp Pro Asp Ser Pro 
    50                  55                  60                  
Leu His Ser Asp Leu Gln Ile Leu Lys Glu Lys Glu Gly Ile Glu Tyr 
65                  70                  75                  80  
Ile Leu Leu Asn Phe Ser Phe Lys Asp Asn Phe Pro Phe Asp Pro Pro 
                85                  90                  95      
Phe Val Arg Val Val Leu Pro Val Leu Ser Gly Gly Tyr Val Leu Gly 
            100                 105                 110         
Gly Gly Ala Leu Cys Met Glu Leu Leu Thr Lys Gln Gly Trp Ser Ser 
        115                 120                 125             
Ala Tyr Ser Ile Glu Ser Val Ile Met Gln Ile Asn Ala Thr Leu Val 
    130                 135                 140                 
Lys Gly Lys Ala Arg Val Gln Phe Gly Ala Asn Lys Asn Gln Tyr Asn 
145                 150                 155                 160 
Leu Ala Arg Ala Gln Gln Ser Tyr Asn Ser Ile Val Gln Ile His Glu 
                165                 170                 175     
Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         
Ser Ser Arg Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala 
        195                 200                 205             
Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val 
    210                 215                 220                 
Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val 
225                 230                 235                 240 
Trp Gln Glu Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser 
                245                 250                 255     
Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser 
            260                 265                 270         
Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg 
        275                 280                 285             
Thr 
    

<210> 187
<211> 300
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2R1_Linker 2_aCS3

<400> 187
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Ser Ser Gln Lys Ala Leu 
1               5                   10                  15      
Leu Leu Glu Leu Lys Gly Leu Gln Glu Glu Pro Val Glu Gly Phe Arg 
            20                  25                  30          
Val Thr Leu Val Asp Glu Gly Asp Leu Tyr Asn Trp Glu Val Ala Ile 
        35                  40                  45              
Phe Gly Pro Pro Asn Thr Tyr Tyr Glu Gly Gly Tyr Phe Lys Ala Arg 
    50                  55                  60                  
Leu Lys Phe Pro Ile Asp Tyr Pro Tyr Ser Pro Pro Ala Phe Arg Phe 
65                  70                  75                  80  
Leu Thr Lys Met Trp His Pro Asn Ile Tyr Glu Thr Gly Asp Val Cys 
                85                  90                  95      
Ile Ser Ile Leu His Pro Pro Val Asp Asp Pro Gln Ser Gly Glu Leu 
            100                 105                 110         
Pro Ser Glu Arg Trp Asn Pro Thr Gln Asn Val Arg Thr Ile Leu Leu 
        115                 120                 125             
Ser Val Ile Ser Leu Leu Asn Glu Pro Asn Thr Phe Ser Pro Ala Asn 
    130                 135                 140                 
Val Asp Ala Ser Val Met Tyr Arg Lys Trp Lys Glu Ser Lys Gly Lys 
145                 150                 155                 160 
Asp Arg Glu Tyr Thr Asp Ile Ile Arg Lys Gln Val Leu Gly Thr Lys 
                165                 170                 175     
Val Asp Ala Glu Arg Asp Gly Val Lys Val Pro Leu Glu Gly Gly Gly 
            180                 185                 190         
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser 
        195                 200                 205             
Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
    210                 215                 220                 
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile 
225                 230                 235                 240 
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
                245                 250                 255     
Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
            260                 265                 270         
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
        275                 280                 285             
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
    290                 295                 300 

<210> 188
<211> 277
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2S_Linker 2_aCS3

<400> 188
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asn Ser Asn Val Glu Asn Leu 
1               5                   10                  15      
Pro Pro His Ile Ile Arg Leu Val Tyr Lys Glu Val Thr Thr Leu Thr 
            20                  25                  30          
Ala Asp Pro Pro Asp Gly Ile Lys Val Phe Pro Asn Glu Glu Asp Leu 
        35                  40                  45              
Thr Asp Leu Gln Val Thr Ile Glu Gly Pro Glu Gly Thr Pro Tyr Ala 
    50                  55                  60                  
Gly Gly Leu Phe Arg Met Lys Leu Leu Leu Gly Lys Asp Phe Pro Ala 
65                  70                  75                  80  
Ser Pro Pro Lys Gly Tyr Phe Leu Thr Lys Ile Phe His Pro Asn Val 
                85                  90                  95      
Gly Ala Asn Gly Glu Ile Cys Val Asn Val Leu Lys Arg Asp Trp Thr 
            100                 105                 110         
Ala Glu Leu Gly Ile Arg His Val Leu Leu Thr Ile Lys Cys Leu Leu 
        115                 120                 125             
Ile His Pro Asn Pro Glu Ser Ala Leu Asn Glu Glu Ala Gly Arg Leu 
    130                 135                 140                 
Leu Leu Glu Asn Tyr Glu Glu Tyr Ala Ala Arg Ala Arg Leu Leu Thr 
145                 150                 155                 160 
Glu Ile His Gly Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     
Gly Gly Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr Lys Leu Glu 
            180                 185                 190         
Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        195                 200                 205             
Ala Val Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His 
    210                 215                 220                 
Trp Pro Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser Lys Ser Thr 
225                 230                 235                 240 
Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
                245                 250                 255     
Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser 
            260                 265                 270         
Ile Asn Tyr Arg Thr 
        275         

<210> 189
<211> 288
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2T_Linker 2_aCS3

<400> 189
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gln Arg Ala Ser Arg Leu Lys 
1               5                   10                  15      
Arg Glu Leu His Met Leu Ala Thr Glu Pro Pro Pro Gly Ile Thr Cys 
            20                  25                  30          
Trp Gln Asp Lys Asp Gln Met Asp Asp Leu Arg Ala Gln Ile Leu Gly 
        35                  40                  45              
Gly Ala Asn Thr Pro Tyr Glu Lys Gly Val Phe Lys Leu Glu Val Ile 
    50                  55                  60                  
Ile Pro Glu Arg Tyr Pro Phe Glu Pro Pro Gln Ile Arg Phe Leu Thr 
65                  70                  75                  80  
Pro Ile Tyr His Pro Asn Ile Asp Ser Ala Gly Arg Ile Cys Leu Asp 
                85                  90                  95      
Val Leu Lys Leu Pro Pro Lys Gly Ala Trp Arg Pro Ser Leu Asn Ile 
            100                 105                 110         
Ala Thr Val Leu Thr Ser Ile Gln Leu Leu Met Ser Glu Pro Asn Pro 
        115                 120                 125             
Asp Asp Pro Leu Met Ala Asp Ile Ser Ser Glu Phe Lys Tyr Asn Lys 
    130                 135                 140                 
Pro Ala Phe Leu Lys Asn Ala Arg Gln Trp Thr Glu Lys His Ala Arg 
145                 150                 155                 160 
Gln Lys Gln Lys Ala Asp Glu Glu Glu Met Leu Asp Asn Leu Pro Leu 
                165                 170                 175     
Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            180                 185                 190         
Ser Arg Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr 
        195                 200                 205             
Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp 
    210                 215                 220                 
Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp 
225                 230                 235                 240 
Gln Glu Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly 
                245                 250                 255     
Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr 
            260                 265                 270         
Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
        275                 280                 285             



<210> 190
<211> 271
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2U_Linker 2_aCS3

<400> 190
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala His Gly Arg Ala Tyr Leu Leu 
1               5                   10                  15      
Leu His Arg Asp Phe Cys Asp Leu Lys Glu Asn Asn Tyr Lys Gly Ile 
            20                  25                  30          
Thr Ala Lys Pro Val Ser Glu Asp Met Met Glu Trp Glu Val Glu Ile 
        35                  40                  45              
Glu Gly Leu Gln Asn Ser Val Trp Gln Gly Leu Val Phe Gln Leu Thr 
    50                  55                  60                  
Ile His Phe Thr Ser Glu Tyr Asn Tyr Ala Pro Pro Val Val Lys Phe 
65                  70                  75                  80  
Ile Thr Ile Pro Phe His Pro Asn Val Asp Pro His Thr Gly Gln Pro 
                85                  90                  95      
Cys Ile Asp Phe Leu Asp Asn Pro Glu Lys Trp Asn Thr Asn Tyr Thr 
            100                 105                 110         
Leu Ser Ser Ile Leu Leu Ala Leu Gln Val Met Leu Ser Asn Pro Val 
        115                 120                 125             
Leu Glu Asn Pro Val Asn Leu Glu Ala Ala Arg Ile Leu Val Lys Asp 
    130                 135                 140                 
Glu Ser Leu Tyr Arg Thr Ile Leu Arg Leu Phe Asn Arg Pro Leu Glu 
145                 150                 155                 160 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
                165                 170                 175     
Arg Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro 
            180                 185                 190         
Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr 
        195                 200                 205             
Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln 
    210                 215                 220                 
Glu Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu 
225                 230                 235                 240 
Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser 
                245                 250                 255     
Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
            260                 265                 270     

<210> 191
<211> 239
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2W_Linker 2_aCS3

<400> 191
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Met Ala Ser Met Gln Lys Arg 
1               5                   10                  15      
Leu Gln Lys Glu Leu Leu Ala Leu Gln Asn Asp Pro Pro Pro Gly Met 
            20                  25                  30          
Thr Leu Asn Glu Lys Ser Val Gln Asn Ser Ile Thr Gln Trp Ile Val 
        35                  40                  45              
Asp Met Glu Gly Ala Pro Gly Thr Leu Tyr Glu Gly Glu Lys Phe Gln 
    50                  55                  60                  
Leu Leu Phe Lys Phe Ser Ser Arg Tyr Pro Phe Asp Ser Pro Gln Val 
65                  70                  75                  80  
Met Phe Thr Gly Glu Asn Ile Pro Val His Pro His Val Tyr Ser Asn 
                85                  90                  95      
Gly His Ile Cys Leu Ser Ile Leu Thr Glu Asp Trp Ser Pro Ala Leu 
            100                 105                 110         
Ser Val Gln Ser Val Cys Leu Ser Ile Ile Ser Met Leu Ser Leu Glu 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 
Arg Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro 
145                 150                 155                 160 
Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr 
                165                 170                 175     
Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln 
            180                 185                 190         
Glu Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu 
        195                 200                 205             
Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser 
    210                 215                 220                 
Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
225                 230                 235                 

<210> 192
<211> 325
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_BIRC6_Linker 2_aCS3

<400> 192
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Asn Gln Glu Lys Lys Leu 
1               5                   10                  15      
Gly Glu Tyr Ser Lys Lys Ala Ala Met Lys Pro Lys Pro Leu Ser Val 
            20                  25                  30          
Leu Lys Ser Leu Glu Glu Lys Tyr Val Ala Val Met Lys Lys Leu Gln 
        35                  40                  45              
Phe Asp Thr Phe Glu Met Val Ser Glu Asp Glu Asp Gly Lys Leu Gly 
    50                  55                  60                  
Phe Lys Val Asn Tyr His Tyr Met Ser Gln Val Lys Asn Ala Asn Asp 
65                  70                  75                  80  
Ala Asn Ser Ala Ala Arg Ala Arg Arg Leu Ala Gln Glu Ala Val Thr 
                85                  90                  95      
Leu Ser Thr Ser Leu Pro Leu Ser Ser Ser Ser Ser Val Phe Val Arg 
            100                 105                 110         
Cys Asp Glu Glu Arg Leu Asp Ile Met Lys Val Leu Ile Thr Gly Pro 
        115                 120                 125             
Ala Asp Thr Pro Tyr Ala Asn Gly Cys Phe Glu Phe Asp Val Tyr Phe 
    130                 135                 140                 
Pro Gln Asp Tyr Pro Ser Ser Pro Pro Leu Val Asn Leu Glu Thr Thr 
145                 150                 155                 160 
Gly Gly His Ser Val Arg Phe Asn Pro Asn Leu Tyr Asn Asp Gly Lys 
                165                 170                 175     
Val Cys Leu Ser Ile Leu Asn Thr Trp His Gly Arg Pro Glu Glu Lys 
            180                 185                 190         
Trp Asn Pro Gln Thr Ser Ser Phe Leu Gln Val Leu Val Ser Val Gln 
        195                 200                 205             
Ser Leu Ile Leu Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 
Gly Gly Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr Lys Leu Glu 
225                 230                 235                 240 
Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
                245                 250                 255     
Ala Val Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His 
            260                 265                 270         
Trp Pro Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser Lys Ser Thr 
        275                 280                 285             
Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    290                 295                 300                 
Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser 
305                 310                 315                 320 
Ile Asn Tyr Arg Thr 
                325 

<210> 193
<211> 288
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UFC1_Linker 2_aCS3

<400> 193
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Asp Glu Ala Thr Arg Arg 
1               5                   10                  15      
Val Val Ser Glu Ile Pro Val Leu Lys Thr Asn Ala Gly Pro Arg Asp 
            20                  25                  30          
Arg Glu Leu Trp Val Gln Arg Leu Lys Glu Glu Tyr Gln Ser Leu Ile 
        35                  40                  45              
Arg Tyr Val Glu Asn Asn Lys Asn Ala Asp Asn Asp Trp Phe Arg Leu 
    50                  55                  60                  
Glu Ser Asn Lys Glu Gly Thr Arg Trp Phe Gly Lys Cys Trp Tyr Ile 
65                  70                  75                  80  
His Asp Leu Leu Lys Tyr Glu Phe Asp Ile Glu Phe Asp Ile Pro Ile 
                85                  90                  95      
Thr Tyr Pro Thr Thr Ala Pro Glu Ile Ala Val Pro Glu Leu Asp Gly 
            100                 105                 110         
Lys Thr Ala Lys Met Tyr Arg Gly Gly Lys Ile Cys Leu Thr Asp His 
        115                 120                 125             
Phe Lys Pro Leu Trp Ala Arg Asn Val Pro Lys Phe Gly Leu Ala His 
    130                 135                 140                 
Leu Met Ala Leu Gly Leu Gly Pro Trp Leu Ala Val Glu Ile Pro Asp 
145                 150                 155                 160 
Leu Ile Gln Lys Gly Val Ile Gln His Lys Glu Lys Cys Asn Gln Leu 
                165                 170                 175     
Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            180                 185                 190         
Ser Arg Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr 
        195                 200                 205             
Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp 
    210                 215                 220                 
Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp 
225                 230                 235                 240 
Gln Glu Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly 
                245                 250                 255     
Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr 
            260                 265                 270         
Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
        275                 280                 285             



<210> 194
<211> 254
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_UBE2D1_Linker 4_aCS3

<400> 194
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Leu Lys Arg Ile Gln Lys 
1               5                   10                  15      
Glu Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly 
            20                  25                  30          
Pro Val Gly Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro 
        35                  40                  45              
Pro Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe 
    50                  55                  60                  
Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys 
65                  70                  75                  80  
Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile 
                85                  90                  95      
Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu 
            100                 105                 110         
Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val 
        115                 120                 125             
Pro Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg 
    130                 135                 140                 
His Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met Gly Gly Gly Gly Gly 
145                 150                 155                 160 
Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr 
                165                 170                 175     
Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr 
            180                 185                 190         
Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu 
        195                 200                 205             
Phe Glu Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys 
    210                 215                 220                 
Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser 
225                 230                 235                 240 
Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                245                 250                 

<210> 195
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_aCS3(V33R)_Linker 2_UBE2D1

<400> 195
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Glu Phe Ala Met Val Ser Ser 
1               5                   10                  15      
Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu 
            20                  25                  30          
Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Arg Ile Thr 
        35                  40                  45              
Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val 
    50                  55                  60                  
Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val 
65                  70                  75                  80  
Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr 
                85                  90                  95      
Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr Leu Glu Gly Gly Gly 
            100                 105                 110         
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Ala Leu 
        115                 120                 125             
Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala 
    130                 135                 140                 
His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp Gln Ala 
145                 150                 155                 160 
Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe 
                165                 170                 175     
Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile 
            180                 185                 190         
Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser 
        195                 200                 205             
Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Val 
    210                 215                 220                 
Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro 
225                 230                 235                 240 
Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys 
                245                 250                 255     
Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met 
            260                 265                 270         



<210> 196
<211> 330
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_aCS3_Linker 1_VHL

<400> 196
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Glu Phe Ala Met Val Ser Ser 
1               5                   10                  15      
Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu 
            20                  25                  30          
Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr 
        35                  40                  45              
Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val 
    50                  55                  60                  
Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val 
65                  70                  75                  80  
Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr 
                85                  90                  95      
Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr Leu Glu Gly Gly Gly 
            100                 105                 110         
Gly Ser Ser Arg Ala Met Pro Arg Arg Ala Glu Asn Trp Asp Glu Ala 
        115                 120                 125             
Glu Val Gly Ala Glu Glu Ala Gly Val Glu Glu Tyr Gly Pro Glu Glu 
    130                 135                 140                 
Asp Gly Gly Glu Glu Ser Gly Ala Glu Glu Ser Gly Pro Glu Glu Ser 
145                 150                 155                 160 
Gly Pro Glu Glu Leu Gly Ala Glu Glu Glu Met Glu Ala Gly Arg Pro 
                165                 170                 175     
Arg Pro Val Leu Arg Ser Val Asn Ser Arg Glu Pro Ser Gln Val Ile 
            180                 185                 190         
Phe Cys Asn Arg Ser Pro Arg Val Val Leu Pro Val Trp Leu Asn Phe 
        195                 200                 205             
Asp Gly Glu Pro Gln Pro Tyr Pro Thr Leu Pro Pro Gly Thr Gly Arg 
    210                 215                 220                 
Arg Ile His Ser Tyr Arg Gly His Leu Trp Leu Phe Arg Asp Ala Gly 
225                 230                 235                 240 
Thr His Asp Gly Leu Leu Val Asn Gln Thr Glu Leu Phe Val Pro Ser 
                245                 250                 255     
Leu Asn Val Asp Gly Gln Pro Ile Phe Ala Asn Ile Thr Leu Pro Val 
            260                 265                 270         
Tyr Thr Leu Lys Glu Arg Cys Leu Gln Val Val Arg Ser Leu Val Lys 
        275                 280                 285             
Pro Glu Asn Tyr Arg Arg Leu Asp Ile Val Arg Ser Leu Tyr Glu Asp 
    290                 295                 300                 
Leu Glu Asp His Pro Asn Val Gln Lys Asp Leu Glu Arg Leu Thr Gln 
305                 310                 315                 320 
Glu Arg Ile Ala His Gln Arg Met Gly Asp 
                325                 330 

<210> 197
<211> 340
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_aCS3_ Linker 2_VHL

<400> 197
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Glu Phe Ala Met Val Ser Ser 
1               5                   10                  15      
Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu 
            20                  25                  30          
Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr 
        35                  40                  45              
Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val 
    50                  55                  60                  
Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val 
65                  70                  75                  80  
Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr 
                85                  90                  95      
Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr Leu Glu Gly Gly Gly 
            100                 105                 110         
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Ala Met 
        115                 120                 125             
Pro Arg Arg Ala Glu Asn Trp Asp Glu Ala Glu Val Gly Ala Glu Glu 
    130                 135                 140                 
Ala Gly Val Glu Glu Tyr Gly Pro Glu Glu Asp Gly Gly Glu Glu Ser 
145                 150                 155                 160 
Gly Ala Glu Glu Ser Gly Pro Glu Glu Ser Gly Pro Glu Glu Leu Gly 
                165                 170                 175     
Ala Glu Glu Glu Met Glu Ala Gly Arg Pro Arg Pro Val Leu Arg Ser 
            180                 185                 190         
Val Asn Ser Arg Glu Pro Ser Gln Val Ile Phe Cys Asn Arg Ser Pro 
        195                 200                 205             
Arg Val Val Leu Pro Val Trp Leu Asn Phe Asp Gly Glu Pro Gln Pro 
    210                 215                 220                 
Tyr Pro Thr Leu Pro Pro Gly Thr Gly Arg Arg Ile His Ser Tyr Arg 
225                 230                 235                 240 
Gly His Leu Trp Leu Phe Arg Asp Ala Gly Thr His Asp Gly Leu Leu 
                245                 250                 255     
Val Asn Gln Thr Glu Leu Phe Val Pro Ser Leu Asn Val Asp Gly Gln 
            260                 265                 270         
Pro Ile Phe Ala Asn Ile Thr Leu Pro Val Tyr Thr Leu Lys Glu Arg 
        275                 280                 285             
Cys Leu Gln Val Val Arg Ser Leu Val Lys Pro Glu Asn Tyr Arg Arg 
    290                 295                 300                 
Leu Asp Ile Val Arg Ser Leu Tyr Glu Asp Leu Glu Asp His Pro Asn 
305                 310                 315                 320 
Val Gln Lys Asp Leu Glu Arg Leu Thr Gln Glu Arg Ile Ala His Gln 
                325                 330                 335     
Arg Met Gly Asp 
            340 

<210> 198
<211> 397
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_K19_linker 3_VHL

<400> 198
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asp Leu Gly Lys Lys Leu Leu 
1               5                   10                  15      
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala 
            20                  25                  30          
Asn Gly Ala Asp Val Asn Ala Ser Asp Arg Trp Gly Trp Thr Pro Leu 
        35                  40                  45              
His Leu Ala Ala Trp Trp Gly His Leu Glu Ile Val Glu Val Leu Leu 
    50                  55                  60                  
Lys Arg Gly Ala Asp Val Ser Ala Ala Asp Leu His Gly Gln Ser Pro 
65                  70                  75                  80  
Leu His Leu Ala Ala Met Val Gly His Leu Glu Ile Val Glu Val Leu 
                85                  90                  95      
Leu Lys Tyr Gly Ala Asp Val Asn Ala Lys Asp Thr Met Gly Ala Thr 
            100                 105                 110         
Pro Leu His Leu Ala Ala Arg Ser Gly His Leu Glu Ile Val Glu Glu 
        115                 120                 125             
Leu Leu Lys Asn Gly Ala Asp Met Asn Ala Gln Asp Lys Phe Gly Lys 
    130                 135                 140                 
Thr Thr Phe Asp Ile Ser Thr Asp Asn Gly Asn Glu Asp Leu Ala Glu 
145                 150                 155                 160 
Ile Leu Gln Lys Leu Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     
Gly Ser Gly Gly Gly Gly Ser Gly Thr Pro Arg Arg Ala Glu Asn Trp 
            180                 185                 190         
Asp Glu Ala Glu Val Gly Ala Glu Glu Ala Gly Val Glu Glu Tyr Gly 
        195                 200                 205             
Pro Glu Glu Asp Gly Gly Glu Glu Ser Gly Ala Glu Glu Ser Gly Pro 
    210                 215                 220                 
Glu Glu Ser Gly Pro Glu Glu Leu Gly Ala Glu Glu Glu Met Glu Ala 
225                 230                 235                 240 
Gly Arg Pro Arg Pro Val Leu Arg Ser Val Asn Ser Arg Glu Pro Ser 
                245                 250                 255     
Gln Val Ile Phe Cys Asn Arg Ser Pro Arg Val Val Leu Pro Val Trp 
            260                 265                 270         
Leu Asn Phe Asp Gly Glu Pro Gln Pro Tyr Pro Thr Leu Pro Pro Gly 
        275                 280                 285             
Thr Gly Arg Arg Ile His Ser Tyr Arg Gly His Leu Trp Leu Phe Arg 
    290                 295                 300                 
Asp Ala Gly Thr His Asp Gly Leu Leu Val Asn Gln Thr Glu Leu Phe 
305                 310                 315                 320 
Val Pro Ser Leu Asn Val Asp Gly Gln Pro Ile Phe Ala Asn Ile Thr 
                325                 330                 335     
Leu Pro Val Tyr Thr Leu Lys Glu Arg Cys Leu Gln Val Val Arg Ser 
            340                 345                 350         
Leu Val Lys Pro Glu Asn Tyr Arg Arg Leu Asp Ile Val Arg Ser Leu 
        355                 360                 365             
Tyr Glu Asp Leu Glu Asp His Pro Asn Val Gln Lys Asp Leu Glu Arg 
    370                 375                 380                 
Leu Thr Gln Glu Arg Ile Ala His Gln Arg Met Gly Asp 
385                 390                 395         

<210> 199
<211> 395
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_E3_5_linker 3_VHL

<400> 199
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asp Leu Gly Lys Lys Leu Leu 
1               5                   10                  15      
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala 
            20                  25                  30          
Asn Gly Ala Asp Val Asn Ala Thr Asp Asn Asp Gly Tyr Thr Pro Leu 
        35                  40                  45              
His Leu Ala Ala Ser Asn Gly His Leu Glu Ile Val Glu Val Leu Leu 
    50                  55                  60                  
Lys Asn Gly Ala Asp Val Asn Ala Ser Asp Leu Thr Gly Ile Thr Pro 
65                  70                  75                  80  
Leu His Leu Ala Ala Ala Thr Gly His Leu Glu Ile Val Glu Val Leu 
                85                  90                  95      
Leu Lys His Gly Ala Asp Val Asn Ala Tyr Asp Asn Asp Gly His Thr 
            100                 105                 110         
Pro Leu His Leu Ala Ala Lys Tyr Gly His Leu Glu Ile Val Glu Val 
        115                 120                 125             
Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys 
    130                 135                 140                 
Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu 
145                 150                 155                 160 
Ile Leu Gln Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     
Gly Gly Gly Gly Ser Gly Thr Pro Arg Arg Ala Glu Asn Trp Asp Glu 
            180                 185                 190         
Ala Glu Val Gly Ala Glu Glu Ala Gly Val Glu Glu Tyr Gly Pro Glu 
        195                 200                 205             
Glu Asp Gly Gly Glu Glu Ser Gly Ala Glu Glu Ser Gly Pro Glu Glu 
    210                 215                 220                 
Ser Gly Pro Glu Glu Leu Gly Ala Glu Glu Glu Met Glu Ala Gly Arg 
225                 230                 235                 240 
Pro Arg Pro Val Leu Arg Ser Val Asn Ser Arg Glu Pro Ser Gln Val 
                245                 250                 255     
Ile Phe Cys Asn Arg Ser Pro Arg Val Val Leu Pro Val Trp Leu Asn 
            260                 265                 270         
Phe Asp Gly Glu Pro Gln Pro Tyr Pro Thr Leu Pro Pro Gly Thr Gly 
        275                 280                 285             
Arg Arg Ile His Ser Tyr Arg Gly His Leu Trp Leu Phe Arg Asp Ala 
    290                 295                 300                 
Gly Thr His Asp Gly Leu Leu Val Asn Gln Thr Glu Leu Phe Val Pro 
305                 310                 315                 320 
Ser Leu Asn Val Asp Gly Gln Pro Ile Phe Ala Asn Ile Thr Leu Pro 
                325                 330                 335     
Val Tyr Thr Leu Lys Glu Arg Cys Leu Gln Val Val Arg Ser Leu Val 
            340                 345                 350         
Lys Pro Glu Asn Tyr Arg Arg Leu Asp Ile Val Arg Ser Leu Tyr Glu 
        355                 360                 365             
Asp Leu Glu Asp His Pro Asn Val Gln Lys Asp Leu Glu Arg Leu Thr 
    370                 375                 380                 
Gln Glu Arg Ile Ala His Gln Arg Met Gly Asp 
385                 390                 395 

<210> 200
<211> 326
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_aCS3_Linker 4_VHL

<400> 200
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Glu Phe Ala Met Val Ser Ser 
1               5                   10                  15      
Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu 
            20                  25                  30          
Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr 
        35                  40                  45              
Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val 
    50                  55                  60                  
Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val 
65                  70                  75                  80  
Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr 
                85                  90                  95      
Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr Gly Gly Gly Gly Gly 
            100                 105                 110         
Ala Met Pro Arg Arg Ala Glu Asn Trp Asp Glu Ala Glu Val Gly Ala 
        115                 120                 125             
Glu Glu Ala Gly Val Glu Glu Tyr Gly Pro Glu Glu Asp Gly Gly Glu 
    130                 135                 140                 
Glu Ser Gly Ala Glu Glu Ser Gly Pro Glu Glu Ser Gly Pro Glu Glu 
145                 150                 155                 160 
Leu Gly Ala Glu Glu Glu Met Glu Val Gly Arg Pro Arg Pro Val Leu 
                165                 170                 175     
Arg Ser Val Asn Ser Arg Glu Pro Ser Gln Val Ile Phe Cys Asn Arg 
            180                 185                 190         
Ser Pro Arg Val Val Leu Pro Val Trp Leu Asn Phe Asp Gly Glu Pro 
        195                 200                 205             
Gln Pro Tyr Pro Thr Leu Pro Pro Gly Thr Gly Arg Arg Ile His Ser 
    210                 215                 220                 
Tyr Arg Gly His Leu Trp Leu Phe Arg Asp Ala Gly Thr His Asp Gly 
225                 230                 235                 240 
Leu Leu Val Asn Gln Thr Glu Leu Phe Val Pro Ser Leu Asn Val Asp 
                245                 250                 255     
Gly Gln Pro Ile Phe Ala Asn Ile Thr Leu Pro Val Tyr Thr Leu Lys 
            260                 265                 270         
Glu Arg Cys Leu Gln Val Val Arg Ser Leu Val Lys Pro Glu Asn Tyr 
        275                 280                 285             
Arg Arg Leu Asp Ile Val Arg Ser Leu Tyr Glu Asp Leu Glu Asp His 
    290                 295                 300                 
Pro Asn Val Gln Lys Asp Leu Glu Arg Leu Thr Gln Glu Arg Ile Ala 
305                 310                 315                 320 
His Gln Arg Met Gly Asp 
                325     

<210> 201
<211> 340
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_aCS3 (V33R)_ Linker 2_VHL

<400> 201
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Glu Phe Ala Met Val Ser Ser 
1               5                   10                  15      
Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu 
            20                  25                  30          
Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Arg Ile Thr 
        35                  40                  45              
Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val 
    50                  55                  60                  
Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val 
65                  70                  75                  80  
Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr 
                85                  90                  95      
Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr Leu Glu Gly Gly Gly 
            100                 105                 110         
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Ala Met 
        115                 120                 125             
Pro Arg Arg Ala Glu Asn Trp Asp Glu Ala Glu Val Gly Ala Glu Glu 
    130                 135                 140                 
Ala Gly Val Glu Glu Tyr Gly Pro Glu Glu Asp Gly Gly Glu Glu Ser 
145                 150                 155                 160 
Gly Ala Glu Glu Ser Gly Pro Glu Glu Ser Gly Pro Glu Glu Leu Gly 
                165                 170                 175     
Ala Glu Glu Glu Met Glu Ala Gly Arg Pro Arg Pro Val Leu Arg Ser 
            180                 185                 190         
Val Asn Ser Arg Glu Pro Ser Gln Val Ile Phe Cys Asn Arg Ser Pro 
        195                 200                 205             
Arg Val Val Leu Pro Val Trp Leu Asn Phe Asp Gly Glu Pro Gln Pro 
    210                 215                 220                 
Tyr Pro Thr Leu Pro Pro Gly Thr Gly Arg Arg Ile His Ser Tyr Arg 
225                 230                 235                 240 
Gly His Leu Trp Leu Phe Arg Asp Ala Gly Thr His Asp Gly Leu Leu 
                245                 250                 255     
Val Asn Gln Thr Glu Leu Phe Val Pro Ser Leu Asn Val Asp Gly Gln 
            260                 265                 270         
Pro Ile Phe Ala Asn Ile Thr Leu Pro Val Tyr Thr Leu Lys Glu Arg 
        275                 280                 285             
Cys Leu Gln Val Val Arg Ser Leu Val Lys Pro Glu Asn Tyr Arg Arg 
    290                 295                 300                 
Leu Asp Ile Val Arg Ser Leu Tyr Glu Asp Leu Glu Asp His Pro Asn 
305                 310                 315                 320 
Val Gln Lys Asp Leu Glu Arg Leu Thr Gln Glu Arg Ile Ala His Gln 
                325                 330                 335     
Arg Met Gly Asp 
            340 

<210> 202
<211> 262
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_aCS3_ Linker 1_UBE2D1

<400> 202
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Glu Phe Ala Met Val Ser Ser 
1               5                   10                  15      
Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu 
            20                  25                  30          
Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr 
        35                  40                  45              
Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val 
    50                  55                  60                  
Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val 
65                  70                  75                  80  
Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr 
                85                  90                  95      
Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr Leu Glu Gly Gly Gly 
            100                 105                 110         
Gly Ser Ser Arg Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu 
        115                 120                 125             
Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp 
    130                 135                 140                 
Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr 
145                 150                 155                 160 
Gln Gly Gly Val Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro 
                165                 170                 175     
Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn 
            180                 185                 190         
Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp 
        195                 200                 205             
Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu 
    210                 215                 220                 
Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln 
225                 230                 235                 240 
Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp 
                245                 250                 255     
Thr Gln Lys Tyr Ala Met 
            260         

<210> 203
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_aCS3_ Linker 2_UBE2D1

<400> 203
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Glu Phe Ala Met Val Ser Ser 
1               5                   10                  15      
Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu 
            20                  25                  30          
Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr 
        35                  40                  45              
Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val 
    50                  55                  60                  
Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val 
65                  70                  75                  80  
Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr 
                85                  90                  95      
Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr Leu Glu Gly Gly Gly 
            100                 105                 110         
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Ala Leu 
        115                 120                 125             
Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala 
    130                 135                 140                 
His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp Gln Ala 
145                 150                 155                 160 
Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe 
                165                 170                 175     
Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile 
            180                 185                 190         
Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser 
        195                 200                 205             
Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Val 
    210                 215                 220                 
Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro 
225                 230                 235                 240 
Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys 
                245                 250                 255     
Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met 
            260                 265                 270         



<210> 204
<211> 331
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_K19_linker 3_UBE2D1

<400> 204
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asp Leu Gly Lys Lys Leu Leu 
1               5                   10                  15      
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala 
            20                  25                  30          
Asn Gly Ala Asp Val Asn Ala Ser Asp Arg Trp Gly Trp Thr Pro Leu 
        35                  40                  45              
His Leu Ala Ala Trp Trp Gly His Leu Glu Ile Val Glu Val Leu Leu 
    50                  55                  60                  
Lys Arg Gly Ala Asp Val Ser Ala Ala Asp Leu His Gly Gln Ser Pro 
65                  70                  75                  80  
Leu His Leu Ala Ala Met Val Gly His Leu Glu Ile Val Glu Val Leu 
                85                  90                  95      
Leu Lys Tyr Gly Ala Asp Val Asn Ala Lys Asp Thr Met Gly Ala Thr 
            100                 105                 110         
Pro Leu His Leu Ala Ala Arg Ser Gly His Leu Glu Ile Val Glu Glu 
        115                 120                 125             
Leu Leu Lys Asn Gly Ala Asp Met Asn Ala Gln Asp Lys Phe Gly Lys 
    130                 135                 140                 
Thr Thr Phe Asp Ile Ser Thr Asp Asn Gly Asn Glu Asp Leu Ala Glu 
145                 150                 155                 160 
Ile Leu Gln Lys Leu Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     
Gly Ser Gly Gly Gly Gly Ser Gly Thr Ala Leu Lys Arg Ile Gln Lys 
            180                 185                 190         
Glu Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly 
        195                 200                 205             
Pro Val Gly Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro 
    210                 215                 220                 
Pro Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe 
225                 230                 235                 240 
Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys 
                245                 250                 255     
Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile 
            260                 265                 270         
Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu 
        275                 280                 285             
Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val 
    290                 295                 300                 
Pro Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg 
305                 310                 315                 320 
His Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met 
                325                 330     

<210> 205
<211> 329
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; HA_E3_5__linker 3_UBE2D1

<400> 205
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asp Leu Gly Lys Lys Leu Leu 
1               5                   10                  15      
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala 
            20                  25                  30          
Asn Gly Ala Asp Val Asn Ala Thr Asp Asn Asp Gly Tyr Thr Pro Leu 
        35                  40                  45              
His Leu Ala Ala Ser Asn Gly His Leu Glu Ile Val Glu Val Leu Leu 
    50                  55                  60                  
Lys Asn Gly Ala Asp Val Asn Ala Ser Asp Leu Thr Gly Ile Thr Pro 
65                  70                  75                  80  
Leu His Leu Ala Ala Ala Thr Gly His Leu Glu Ile Val Glu Val Leu 
                85                  90                  95      
Leu Lys His Gly Ala Asp Val Asn Ala Tyr Asp Asn Asp Gly His Thr 
            100                 105                 110         
Pro Leu His Leu Ala Ala Lys Tyr Gly His Leu Glu Ile Val Glu Val 
        115                 120                 125             
Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys 
    130                 135                 140                 
Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu 
145                 150                 155                 160 
Ile Leu Gln Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     
Gly Gly Gly Gly Ser Gly Thr Ala Leu Lys Arg Ile Gln Lys Glu Leu 
            180                 185                 190         
Ser Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly Pro Val 
        195                 200                 205             
Gly Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro Pro Asp 
    210                 215                 220                 
Ser Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe Pro Thr 
225                 230                 235                 240 
Asp Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys Ile Tyr 
                245                 250                 255     
His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg 
            260                 265                 270         
Ser Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu Ser Ile 
        275                 280                 285             
Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val Pro Asp 
    290                 295                 300                 
Ile Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg His Ala 
305                 310                 315                 320 
Arg Glu Trp Thr Gln Lys Tyr Ala Met 
                325                 

<210> 206
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; PxxxP motif

<220> 
<221> VARIANT
<222> 2..5
<223> Wherein Xaa is any amino acid

<400> 206
Pro Xaa Xaa Xaa Pro 
1               5   

<210> 207
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; PxxPP motif

<220> 
<221> VARIANT
<222> 2..3
<223> Wherein Xaa is any amino acid

<400> 207
Pro Xaa Xaa Pro Pro 
1               5   

<210> 208
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; TPNGRF motif

<400> 208
Thr Pro Asn Gly Arg Phe 
1               5       

<210> 209
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; TANGRF motif

<400> 209
Thr Ala Asn Gly Arg Phe 
1               5       

<210> 210
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic; TxNGRF motif

<220> 
<221> VARIANT
<222> 2
<223> Wherein Xaa is any amino acid

<400> 210
Thr Xaa Asn Gly Arg Phe 
1               5       

<210> 211
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker 7

<400> 211
Leu Glu Gly Gly Ser Arg 
1               5       

<210> 212
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker 8

<400> 212
Leu Glu Gly Gly Gly Ser Gly Gly Ser Ser Arg 
1               5                   10      

<210> 213
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker 9

<400> 213
Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Ser Ser Arg 
1               5                   10              

<210> 214
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker 10

<400> 214
Leu Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Ser Arg 
1               5                   10                  15      



<210> 215
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker 11

<400> 215
Leu Glu Gly Gly Gly Gly Ser Gly Pro Ser Gly Gly Gly Gly Pro Ser 
1               5                   10                  15      
Gly Ser Arg 
            

<210> 216
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker 12

<400> 216
Leu Glu Ser Asn Gly Gly Gly Gly Ser Pro Ala Pro Ala Pro Gly Gly 
1               5                   10                  15      
Gly Gly Ser Gly Ser Ser Arg 
            20              

<210> 217
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker 13

<400> 217
Leu Glu Gly Gly Gly Gly Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   10                  15      
Ser Gly Gly Gly Gly Ser Ser Arg 
            20                  

<210> 218
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker 14

<400> 218
Thr Gly Gly Ser Ala Gly Gly Ser Gly Gly Ser Ala Gly Gly Ser Gly 
1               5                   10                  15      
Gly Ser Ala Gly Gly Ser Gly Gly Ser Ala 
            20                  25      

<210> 219
<211> 28
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker 15

<400> 219
Ala Gly Ser Gly Gly Ser Thr Gly Ser Gly Gly Ser Pro Thr Pro Ser 
1               5                   10                  15      
Thr Ser Gly Gly Ser Thr Gly Ser Gly Gly Ala Ser 
            20                  25              

<210> 220
<211> 28
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker 16

<400> 220
Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Asn Ser Ser 
1               5                   10                  15      
Thr Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Ser 
            20                  25              

<210> 221
<211> 28
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker 17

<400> 221
Gly Gly Ser Pro Val Pro Ser Thr Pro Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      
Ser Gly Gly Ser Pro Val Pro Ser Thr Pro Gly Ser 
            20                  25              

<210> 222
<211> 28
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker 18

<400> 222
Ser Pro Gly Thr Gly Ser Pro Gly Thr Gly Ser Pro Gly Thr Gly Ser 
1               5                   10                  15      
Pro Gly Thr Gly Ser Pro Gly Thr Gly Ser Pro Gly 
            20                  25              

<210> 223
<211> 774
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2D1_Linker 7_aCS3(K7Q,K55Y,K64H)_HA

<400> 223
gccttgaagc ggattcagaa agagctgagc gacctgcaga gggaccctcc tgctcactgt      60

tctgctggac ccgtgggaga tgacctgttc cactggcaag ccaccatcat gggccctcca     120

gatagcgcct atcaaggcgg cgtgttcttc ctgaccgtgc acttccccac agactacccc     180

ttcaagcctc ctaagatcgc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gatatcgccc agatctacaa gagcgacaaa gagaagtaca accggcacgc cagagagtgg     420

acccagaaat acgctatgct ggaaggcggc tctagagtgt ccagcgtgcc cacacagctg     480

gaagtggttg ccgccacacc tacaagcctg ctgatctctt gggatgcccc tgccgtgaca     540

gtggactact acgtgatcac ctacggcgag acaggccact ggccttgggt ctggcaagag     600

tttgaagtgc ccggcagcta cagcaccgcc acaatttctg gactgcaccc cggcgtggac     660

tacaccatca cagtgtacgc cggctcctac agcagctact actactatgg cagccccatc     720

agcatcaact accggacagg cggctacccc tacgacgtgc cagattatgc ttga           774


<210> 224
<211> 789
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 8_aCS3 (K7Q,K55Y,K64H)_HA

<400> 224
gccttgaagc ggattcagaa agagctgagc gacctgcaga gggaccctcc tgctcactgt      60

tctgctggac ccgtgggaga tgacctgttc cactggcaag ccaccatcat gggccctcca     120

gatagcgcct atcaaggcgg cgtgttcttc ctgaccgtgc acttccccac agactacccc     180

ttcaagcctc ctaagatcgc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gatatcgccc agatctacaa gagcgacaaa gagaagtaca accggcacgc cagagagtgg     420

acccagaaat acgctatgct ggaaggcggc ggaagcggcg gatcttctag agtgtccagc     480

gtgcccacac agctggaagt ggttgccgcc acacctacaa gcctgctgat ctcttgggat     540

gcccctgccg tgacagtgga ctactacgtg atcacctacg gcgagacagg ccactggcct     600

tgggtctggc aagagtttga agtgcccggc agctacagca ccgccacaat ttctggactg     660

caccccggcg tggactacac catcacagtg tacgccggct cctacagcag ctactactac     720

tatggcagcc ccatcagcat caactaccgg acaggcggct acccctacga cgtgccagat     780

tatgcttga                                                             789


<210> 225
<211> 795
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 9_aCS3 (K7Q,K55Y,K64H)_HA

<400> 225
gccttgaagc ggattcagaa agagctgagc gacctgcaga gggaccctcc tgctcactgt      60

tctgctggac ccgtgggaga tgacctgttc cactggcaag ccaccatcat gggccctcca     120

gatagcgcct atcaaggcgg cgtgttcttc ctgaccgtgc acttccccac agactacccc     180

ttcaagcctc ctaagatcgc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gatatcgccc agatctacaa gagcgacaaa gagaagtaca accggcacgc cagagagtgg     420

acccagaaat acgctatgct ggaaggcggc ggaggatctg gtggtggatc ttctagagtg     480

tccagcgtgc ccacacagct ggaagtggtt gccgccacac ctacaagcct gctgatctct     540

tgggatgccc ctgccgtgac agtggactac tacgtgatca cctacggcga gacaggccac     600

tggccttggg tctggcaaga gtttgaagtg cccggcagct acagcaccgc cacaatttct     660

ggactgcacc ccggcgtgga ctacaccatc acagtgtacg ccggctccta cagcagctac     720

tactactatg gcagccccat cagcatcaac taccggacag gcggctaccc ctacgacgtg     780

ccagattatg cttga                                                      795


<210> 226
<211> 804
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 10_aCS3(K7Q,K55Y,K64H)_HA

<400> 226
gccttgaagc ggattcagaa agagctgagc gacctgcaga gggaccctcc tgctcactgt      60

tctgctggac ccgtgggaga tgacctgttc cactggcaag ccaccatcat gggccctcca     120

gatagcgcct atcaaggcgg cgtgttcttc ctgaccgtgc acttccccac agactacccc     180

ttcaagcctc ctaagatcgc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gatatcgccc agatctacaa gagcgacaaa gagaagtaca accggcacgc cagagagtgg     420

acccagaaat acgctatgct ggaaggcggc ggaagcggcg gagggagcgg tggtggatct     480

tctagagtgt ccagcgtgcc cacacagctg gaagtggttg ccgccacacc tacaagcctg     540

ctgatctctt gggatgcccc tgccgtgaca gtggactact acgtgatcac ctacggcgag     600

acaggccact ggccttgggt ctggcaagag tttgaagtgc ccggcagcta cagcaccgcc     660

acaatttctg gactgcaccc cggcgtggac tacaccatca cagtgtacgc cggctcctac     720

agcagctact actactatgg cagccccatc agcatcaact accggacagg cggctacccc     780

tacgacgtgc cagattatgc ttga                                            804


<210> 227
<211> 813
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 2_aCS3(K7Q,K55Y,K64H)_HA

<400> 227
gccttgaagc ggattcagaa agagctgagc gacctgcaga gggaccctcc tgctcactgt      60

tctgctggac ccgtgggaga tgacctgttc cactggcaag ccaccatcat gggccctcca     120

gatagcgcct atcaaggcgg cgtgttcttc ctgaccgtgc acttccccac agactacccc     180

ttcaagcctc ctaagatcgc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gatatcgccc agatctacaa gagcgacaaa gagaagtaca accggcacgc cagagagtgg     420

acccagaaat acgctatgct ggaaggcggc ggaggatctg gcggaggcgg tagcggtggt     480

ggtggatctt ctagagtgtc cagcgtgccc acacagctgg aagtggttgc cgccacacct     540

acaagcctgc tgatctcttg ggatgcccct gccgtgacag tggactacta cgtgatcacc     600

tacggcgaga caggccactg gccttgggtc tggcaagagt ttgaagtgcc cggcagctac     660

agcaccgcca caatttctgg actgcacccc ggcgtggact acaccatcac agtgtacgcc     720

ggctcctaca gcagctacta ctactatggc agccccatca gcatcaacta ccggacaggc     780

ggctacccct acgacgtgcc agattatgct tga                                  813


<210> 228
<211> 813
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 11_aCS3(K7Q,K55Y,K64H)_HA

<400> 228
gccttgaagc ggattcagaa agagctgagc gacctgcaga gggaccctcc tgctcactgt      60

tctgctggac ccgtgggaga tgacctgttc cactggcaag ccaccatcat gggccctcca     120

gatagcgcct atcaaggcgg cgtgttcttc ctgaccgtgc acttccccac agactacccc     180

ttcaagcctc ctaagatcgc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gatatcgccc agatctacaa gagcgacaaa gagaagtaca accggcacgc cagagagtgg     420

acccagaaat acgctatgct ggaaggcggc ggaggctctg gaccttctgg tggcggagga     480

ccatctggct ctagagtgtc tagcgtgccc acacagctgg aagtggtggc cgctacacct     540

acaagcctgc tgatctcttg ggatgcccct gccgtgacag tggactacta cgtgatcacc     600

tacggcgaga caggccactg gccttgggtc tggcaagagt ttgaagtgcc cggcagctac     660

agcaccgcca caatttctgg actgcacccc ggcgtggact acaccatcac agtgtacgcc     720

ggctcctaca gcagctacta ctactatggc agccccatca gcatcaacta ccggacaggc     780

ggctacccct acgacgtgcc agattatgct tga                                  813


<210> 229
<211> 825
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 12_aCS3(K7Q,K55Y,K64H)_HA

<400> 229
gccctgaaga gaatccagaa agagctgagc gacctgcagc gggatcctcc tgctcactgt      60

tctgctggac ccgtgggaga tgacctgttc cactggcaag ccaccatcat gggccctcca     120

gatagcgcct atcaaggcgg cgtgttcttc ctgaccgtgc acttccccac agactacccc     180

ttcaagcctc ctaagatcgc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gatatcgccc agatctacaa gagcgacaaa gagaagtaca accggcacgc cagagagtgg     420

acccagaaat acgccatgct ggaaagcaat ggcggcggag gatctccagc tcctgctcct     480

ggcggaggcg gatctggatc ttctagagtg tccagcgtgc ccacacagct ggaagtggtt     540

gccgccacac ctacaagcct gctgatctct tgggatgccc ctgccgtgac agtggactac     600

tacgtgatca cctacggcga gacaggccac tggccttggg tctggcaaga gtttgaagtg     660

cccggcagct acagcaccgc cacaatttct ggactgcacc ccggcgtgga ctacaccatc     720

acagtgtacg ccggctccta cagcagctac tactactatg gcagccccat cagcatcaac     780

taccggacag gcggctaccc ctacgacgtg ccagattatg cttga                     825


<210> 230
<211> 840
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 13_aCS3(K7Q,K55Y,K64H)_HA

<400> 230
gccttgaagc ggattcagaa agagctgagc gacctgcaga gggaccctcc tgctcactgt      60

tctgctggac ccgtgggaga tgacctgttc cactggcaag ccaccatcat gggccctcca     120

gatagcgcct atcaaggcgg cgtgttcttc ctgaccgtgc acttccccac agactacccc     180

ttcaagcctc ctaagatcgc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gatatcgccc agatctacaa gagcgacaaa gagaagtaca accggcacgc cagagagtgg     420

acccagaaat acgccatgtc tcccggaaca ggctctcctg gcacaggcag tcctggaact     480

ggatcaccag gcacaggttc tccaggcact ggaagccctg gtgtcagctc tgtgcctaca     540

cagctggaag tggtggccgc cacacctaca agcctgctga tctcttggga tgcccctgcc     600

gtgacagtgg actactacgt gatcacctac ggcgagacag gccactggcc ttgggtctgg     660

caagagtttg aagtgcccgg cagctacagc accgccacaa tttctggact gcaccccggc     720

gtggactaca ccatcacagt gtacgccggc tcctacagca gctactacta ctatggcagc     780

cccatcagca tcaactaccg gacaggcggc tacccctacg acgtgccaga ttatgcttga     840


<210> 231
<211> 834
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 14_aCS3(K7Q,K55Y,K64H)_HA

<400> 231
gccttgaagc ggattcagaa agagctgagc gacctgcaga gggaccctcc tgctcactgt      60

tctgctggac ccgtgggaga tgacctgttc cactggcaag ccaccatcat gggccctcca     120

gatagcgcct atcaaggcgg cgtgttcttc ctgaccgtgc acttccccac agactacccc     180

ttcaagcctc ctaagatcgc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gatatcgccc agatctacaa gagcgacaaa gagaagtaca accggcacgc cagagagtgg     420

acccagaaat acgctatgac aggcggatct gccggcggaa gcggaggtag tgctggtgga     480

tctggtggtt cagctggtgg cagcggagga tctgctgtca gctctgtgcc tacacagctg     540

gaagtggtgg ccgccacacc tacaagcctg ctgatctctt gggatgcccc tgccgtgaca     600

gtggactact acgtgatcac ctacggcgag acaggccact ggccttgggt ctggcaagag     660

tttgaagtgc ccggcagcta cagcaccgcc acaatttctg gactgcaccc cggcgtggac     720

tacaccatca cagtgtacgc cggctcctac agcagctact actactatgg cagccccatc     780

agcatcaact accggacagg cggctacccc tacgacgtgc cagattatgc ttga           834


<210> 232
<211> 877
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 15_aCS3(K7Q,K55Y,K64H)_HA

<400> 232
tattcactcg aggccgccac catggccttg aagcggattc agaaagagct gagcgacctg      60

cagagggacc ctcctgctca ctgttctgct ggacccgtgg gagatgacct gttccactgg     120

caagccacca tcatgggccc tccagatagc gcctatcaag gcggcgtgtt cttcctgacc     180

gtgcacttcc ccacagacta ccccttcaag cctcctaaga tcgccttcac caccaagatc     240

tatcacccca acatcaacag caacggcagc atctgcctgg acatcctgag aagccaatgg     300

tcccctgctc tgaccgtgtc caaggtgctg ctgagcatct gcagcctgct gtgcgacccc     360

aatcctgacg atcctctggt gcctgatatc gcccagatct acaagagcga caaagagaag     420

tacaaccggc acgccagaga gtggacccag aaatacgcta tggccggctc tggcggctct     480

acaggatctg gtggaagccc tacacctagc acatctggcg gaagcacagg ttctggcgga     540

gcctctgtta gcagcgtgcc aacacagctg gaagtggtgg ccgccacacc tacaagcctg     600

ctgatctctt gggatgcccc tgccgtgaca gtggactact acgtgatcac ctacggcgag     660

acaggccact ggccttgggt ctggcaagag tttgaagtgc ccggcagcta cagcaccgcc     720

acaatttctg gactgcaccc cggcgtggac tacaccatca cagtgtacgc cggctcctac     780

agcagctact actactatgg cagccccatc agcatcaact accggacagg cggctacccc     840

tacgacgtgc cagattatgc ttgactagtg catcaca                              877


<210> 233
<211> 840
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 16_aCS3(K7Q,K55Y,K64H)_HA

<400> 233
gccttgaagc ggattcagaa agagctgagc gacctgcaga gggaccctcc tgctcactgt      60

tctgctggac ccgtgggaga tgacctgttc cactggcaag ccaccatcat gggccctcca     120

gatagcgcct atcaaggcgg cgtgttcttc ctgaccgtgc acttccccac agactacccc     180

ttcaagcctc ctaagatcgc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gatatcgccc agatctacaa gagcgacaaa gagaagtaca accggcacgc cagagagtgg     420

acccagaaat acgctatggc cggctctggt ggcagcggag gttctggtgg atctggcaat     480

agcagcacaa gcggcggatc tggcggaagt ggcggagcct ctgttagctc tgtgcccaca     540

cagctggaag tggtggccgc cacacctaca agcctgctga tctcttggga tgcccctgcc     600

gtgacagtgg actactacgt gatcacctac ggcgagacag gccactggcc ttgggtctgg     660

caagagtttg aagtgcccgg cagctacagc accgccacaa tttctggact gcaccccggc     720

gtggactaca ccatcacagt gtacgccggc tcctacagca gctactacta ctatggcagc     780

cccatcagca tcaactaccg gacaggcggc tacccctacg acgtgccaga ttatgcttga     840


<210> 234
<211> 840
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 17_aCS3(K7Q,K55Y,K64H)_HA

<400> 234
gccttgaagc ggattcagaa agagctgagc gacctgcaga gggaccctcc tgctcactgt      60

tctgctggac ccgtgggaga tgacctgttc cactggcaag ccaccatcat gggccctcca     120

gatagcgcct atcaaggcgg cgtgttcttc ctgaccgtgc acttccccac agactacccc     180

ttcaagcctc ctaagatcgc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gatatcgccc agatctacaa gagcgacaaa gagaagtaca accggcacgc cagagagtgg     420

acccagaaat acgctatggg cggcagccct gtgccttcta cacctggcgg aggaagcggc     480

ggaggatctg gtggatctcc agtgcctagt acaccaggca gcgtgtcctc tgtgcccaca     540

cagctggaag tggtggccgc cacacctaca agcctgctga tctcttggga tgcccctgcc     600

gtgacagtgg actactacgt gatcacctac ggcgagacag gccactggcc ttgggtctgg     660

caagagtttg aagtgcccgg cagctacagc accgccacaa tttctggact gcaccccggc     720

gtggactaca ccatcacagt gtacgccggc tcctacagca gctactacta ctatggcagc     780

cccatcagca tcaactaccg gacaggcggc tacccctacg acgtgccaga ttatgcttga     840


<210> 235
<211> 840
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 18_aCS3(K7Q,K55Y,K64H)_HA

<400> 235
gccttgaagc ggattcagaa agagctgagc gacctgcaga gggaccctcc tgctcactgt      60

tctgctggac ccgtgggaga tgacctgttc cactggcaag ccaccatcat gggccctcca     120

gatagcgcct atcaaggcgg cgtgttcttc ctgaccgtgc acttccccac agactacccc     180

ttcaagcctc ctaagatcgc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gatatcgccc agatctacaa gagcgacaaa gagaagtaca accggcacgc cagagagtgg     420

acccagaaat acgccatgtc tcccggaaca ggctctcctg gcacaggcag tcctggaact     480

ggatcaccag gcacaggttc tccaggcact ggaagccctg gtgtcagctc tgtgcctaca     540

cagctggaag tggtggccgc cacacctaca agcctgctga tctcttggga tgcccctgcc     600

gtgacagtgg actactacgt gatcacctac ggcgagacag gccactggcc ttgggtctgg     660

caagagtttg aagtgcccgg cagctacagc accgccacaa tttctggact gcaccccggc     720

gtggactaca ccatcacagt gtacgccggc tcctacagca gctactacta ctatggcagc     780

cccatcagca tcaactaccg gacaggcggc tacccctacg acgtgccaga ttatgcttga     840


<210> 236
<211> 257
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1_Linker 7_aCS3(K7Q,K55Y,K64H)_HA

<400> 236
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met Leu Glu Gly Gly Ser Arg Val Ser Ser Val Pro Thr Gln Leu 
145                 150                 155                 160 
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala 
                165                 170                 175     
Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly 
            180                 185                 190         
His Trp Pro Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser Tyr Ser 
        195                 200                 205             
Thr Ala Thr Ile Ser Gly Leu His Pro Gly Val Asp Tyr Thr Ile Thr 
    210                 215                 220                 
Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile 
225                 230                 235                 240 
Ser Ile Asn Tyr Arg Thr Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr 
                245                 250                 255     
Ala 
    

<210> 237
<211> 262
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 8_aCS3 (K7Q,K55Y,K64H)_HA

<400> 237
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met Leu Glu Gly Gly Gly Ser Gly Gly Ser Ser Arg Val Ser Ser 
145                 150                 155                 160 
Val Pro Thr Gln Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu 
                165                 170                 175     
Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr 
            180                 185                 190         
Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val 
        195                 200                 205             
Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu His Pro Gly Val 
    210                 215                 220                 
Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr 
225                 230                 235                 240 
Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr Gly Gly Tyr Pro Tyr 
                245                 250                 255     
Asp Val Pro Asp Tyr Ala 
            260         

<210> 238
<211> 264
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 9_aCS3 (K7Q,K55Y,K64H)_HA

<400> 238
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Ser Ser Arg Val 
145                 150                 155                 160 
Ser Ser Val Pro Thr Gln Leu Glu Val Val Ala Ala Thr Pro Thr Ser 
                165                 170                 175     
Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val 
            180                 185                 190         
Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe 
        195                 200                 205             
Glu Val Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu His Pro 
    210                 215                 220                 
Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr 
225                 230                 235                 240 
Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr Gly Gly Tyr 
                245                 250                 255     
Pro Tyr Asp Val Pro Asp Tyr Ala 
            260                 

<210> 239
<211> 267
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 10_aCS3(K7Q,K55Y,K64H)_HA

<400> 239
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met Leu Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
145                 150                 155                 160 
Ser Arg Val Ser Ser Val Pro Thr Gln Leu Glu Val Val Ala Ala Thr 
                165                 170                 175     
Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp 
            180                 185                 190         
Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp 
        195                 200                 205             
Gln Glu Phe Glu Val Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly 
    210                 215                 220                 
Leu His Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr 
225                 230                 235                 240 
Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                245                 250                 255     
Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            260                 265         

<210> 240
<211> 270
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 2_aCS3(K7Q,K55Y,K64H)_HA

<400> 240
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 
Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr Gln Leu Glu Val Val 
                165                 170                 175     
Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val 
            180                 185                 190         
Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro 
        195                 200                 205             
Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser Tyr Ser Thr Ala Thr 
    210                 215                 220                 
Ile Ser Gly Leu His Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala 
225                 230                 235                 240 
Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn 
                245                 250                 255     
Tyr Arg Thr Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            260                 265                 270 

<210> 241
<211> 270
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 11_aCS3(K7Q,K55Y,K64H)_HA

<400> 241
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met Leu Glu Gly Gly Gly Gly Ser Gly Pro Ser Gly Gly Gly Gly 
145                 150                 155                 160 
Pro Ser Gly Ser Arg Val Ser Ser Val Pro Thr Gln Leu Glu Val Val 
                165                 170                 175     
Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val 
            180                 185                 190         
Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro 
        195                 200                 205             
Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser Tyr Ser Thr Ala Thr 
    210                 215                 220                 
Ile Ser Gly Leu His Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala 
225                 230                 235                 240 
Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn 
                245                 250                 255     
Tyr Arg Thr Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            260                 265                 270 

<210> 242
<211> 274
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 12_aCS3(K7Q,K55Y,K64H)_HA

<400> 242
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met Leu Glu Ser Asn Gly Gly Gly Gly Ser Pro Ala Pro Ala Pro 
145                 150                 155                 160 
Gly Gly Gly Gly Ser Gly Ser Ser Arg Val Ser Ser Val Pro Thr Gln 
                165                 170                 175     
Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp 
            180                 185                 190         
Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr 
        195                 200                 205             
Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser Tyr 
    210                 215                 220                 
Ser Thr Ala Thr Ile Ser Gly Leu His Pro Gly Val Asp Tyr Thr Ile 
225                 230                 235                 240 
Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro 
                245                 250                 255     
Ile Ser Ile Asn Tyr Arg Thr Gly Gly Tyr Pro Tyr Asp Val Pro Asp 
            260                 265                 270         
Tyr Ala 
        

<210> 243
<211> 264
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 13_aCS3(K7Q,K55Y,K64H)

<400> 243
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met Leu Glu Gly Gly Gly Gly Ser Tyr Pro Tyr Asp Val Pro Asp 
145                 150                 155                 160 
Tyr Ala Ser Gly Gly Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr 
                165                 170                 175     
Gln Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp 
            180                 185                 190         
Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu 
        195                 200                 205             
Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser 
    210                 215                 220                 
Tyr Ser Thr Ala Thr Ile Ser Gly Leu His Pro Gly Val Asp Tyr Thr 
225                 230                 235                 240 
Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser 
                245                 250                 255     
Pro Ile Ser Ile Asn Tyr Arg Thr 
            260                 

<210> 244
<211> 277
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 14_aCS3(K7Q,K55Y,K64H)_HA

<400> 244
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met Thr Gly Gly Ser Ala Gly Gly Ser Gly Gly Ser Ala Gly Gly 
145                 150                 155                 160 
Ser Gly Gly Ser Ala Gly Gly Ser Gly Gly Ser Ala Val Ser Ser Val 
                165                 170                 175     
Pro Thr Gln Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile 
            180                 185                 190         
Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr Tyr 
        195                 200                 205             
Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val Pro 
    210                 215                 220                 
Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu His Pro Gly Val Asp 
225                 230                 235                 240 
Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr 
                245                 250                 255     
Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr Gly Gly Tyr Pro Tyr Asp 
            260                 265                 270         
Val Pro Asp Tyr Ala 
        275         

<210> 245
<211> 279
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 15_aCS3(K7Q,K55Y,K64H)_HA

<400> 245
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met Ala Gly Ser Gly Gly Ser Thr Gly Ser Gly Gly Ser Pro Thr 
145                 150                 155                 160 
Pro Ser Thr Ser Gly Gly Ser Thr Gly Ser Gly Gly Ala Ser Val Ser 
                165                 170                 175     
Ser Val Pro Thr Gln Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
            180                 185                 190         
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile 
        195                 200                 205             
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
    210                 215                 220                 
Val Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu His Pro Gly 
225                 230                 235                 240 
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
                245                 250                 255     
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr Gly Gly Tyr Pro 
            260                 265                 270         
Tyr Asp Val Pro Asp Tyr Ala 
        275                 

<210> 246
<211> 279
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 16_aCS3(K7Q,K55Y,K64H)_HA

<400> 246
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Asn 
145                 150                 155                 160 
Ser Ser Thr Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Ser Val Ser 
                165                 170                 175     
Ser Val Pro Thr Gln Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
            180                 185                 190         
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile 
        195                 200                 205             
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
    210                 215                 220                 
Val Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu His Pro Gly 
225                 230                 235                 240 
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
                245                 250                 255     
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr Gly Gly Tyr Pro 
            260                 265                 270         
Tyr Asp Val Pro Asp Tyr Ala 
        275                 

<210> 247
<211> 279
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 17_aCS3(K7Q,K55Y,K64H)_HA

<400> 247
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met Gly Gly Ser Pro Val Pro Ser Thr Pro Gly Gly Gly Ser Gly 
145                 150                 155                 160 
Gly Gly Ser Gly Gly Ser Pro Val Pro Ser Thr Pro Gly Ser Val Ser 
                165                 170                 175     
Ser Val Pro Thr Gln Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
            180                 185                 190         
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile 
        195                 200                 205             
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
    210                 215                 220                 
Val Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu His Pro Gly 
225                 230                 235                 240 
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
                245                 250                 255     
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr Gly Gly Tyr Pro 
            260                 265                 270         
Tyr Asp Val Pro Asp Tyr Ala 
        275                 

<210> 248
<211> 279
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker 18_aCS3(K7Q,K55Y,K64H)_HA

<400> 248
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met Ser Pro Gly Thr Gly Ser Pro Gly Thr Gly Ser Pro Gly Thr 
145                 150                 155                 160 
Gly Ser Pro Gly Thr Gly Ser Pro Gly Thr Gly Ser Pro Gly Val Ser 
                165                 170                 175     
Ser Val Pro Thr Gln Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu 
            180                 185                 190         
Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile 
        195                 200                 205             
Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu 
    210                 215                 220                 
Val Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu His Pro Gly 
225                 230                 235                 240 
Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr 
                245                 250                 255     
Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr Gly Gly Tyr Pro 
            260                 265                 270         
Tyr Asp Val Pro Asp Tyr Ala 
        275                 

<210> 249
<211> 993
<212> DNA
<213> Artificial Sequence


<220> 
<223> HA_K19_linker_UBE2D1

<400> 249
tatccctacg acgtgcccga ttatgccgac ctgggcaaga agctgctgga agctgctaga      60

gccggccagg acgatgaagt gcggattctg atggccaacg gcgccgatgt gaacgcctct     120

gatagatggg gatggacccc tctgcatctg gctgcttggt ggggacacct ggaaatcgtg     180

gaagtgctgc tgaagagagg ggccgacgtt tcagccgctg atctgcatgg acagagccca     240

ctgcatctcg ccgccatggt tggacacctt gagattgtcg aggtcctgct gaagtatggc     300

gctgacgtga acgctaagga caccatggga gccacaccac tgcacctggc agctagatct     360

ggccatctgg aaattgtcga agaactgctc aagaatgggg cagacatgaa cgcccaggac     420

aagttcggca agaccacctt cgacatcagc accgacaacg gcaacgagga cctggccgag     480

atcctgcaga aactgctcga gggaggcgga ggatctggcg gaggtggaag tggcggaggc     540

ggctcttcta gagccctgaa gagaatccag aaagagctga gcgacctgca gagagatcct     600

cctgctcact gttctgctgg ccctgtggga gatgacctgt tccactggca agccaccatc     660

atgggccctc cagatagcgc ctatcaaggc ggcgtgttct tcctgaccgt gcacttcccc     720

acagactacc ccttcaagcc tcctaagatc gccttcacca ccaagatcta tcaccccaac     780

atcaacagca acggcagcat ctgcctggac atcctgagaa gccaatggtc ccctgctctg     840

accgtgtcca aggtgctgct gagcatctgc agcctgctgt gcgaccccaa tcctgacgat     900

cctctggtgc ctgatatcgc ccagatctac aagagcgaca aagagaagta caaccggcac     960

gccagagagt ggacccagaa atacgctatg tga                                  993


<210> 250
<211> 993
<212> DNA
<213> Artificial Sequence


<220> 
<223> HA_UBE2D1_linker_K19

<400> 250
tatccctacg acgtgcccga ttatgccgcc ctgaagagaa tccagaaaga gctgagcgac      60

ctgcagagag atcctcctgc tcactgttct gctggccctg tgggagatga cctgttccac     120

tggcaagcca ccatcatggg ccctccagat agcgcctatc aaggcggcgt gttcttcctg     180

accgtgcact tccccacaga ctaccccttc aagcctccta agatcgcctt caccaccaag     240

atctatcacc ccaacatcaa cagcaacggc agcatctgcc tggacatcct gagaagccaa     300

tggtcccctg ctctgaccgt gtccaaggtg ctgctgagca tctgcagcct gctgtgcgac     360

cccaatcctg acgatcctct ggtgcctgat atcgcccaga tctacaagag cgacaaagag     420

aagtacaacc ggcacgccag agagtggacc cagaaatacg ctatgctcga gggaggcgga     480

ggatctggcg gaggtggaag tggcggaggc ggctcttcta gagacctggg caagaagctg     540

ctggaagctg ctagagccgg ccaggacgat gaagtgcgga ttctgatggc caacggcgcc     600

gatgtgaacg cctctgatag atggggatgg acccctctgc atctggctgc ttggtgggga     660

cacctggaaa tcgtggaagt gctgctgaag agaggggccg acgtttcagc cgctgatctg     720

catggacaga gcccactgca tctcgccgcc atggttggac accttgagat tgtcgaggtc     780

ctgctgaagt atggcgctga cgtgaacgct aaggacacca tgggagccac accactgcac     840

ctggcagcta gatctggcca tctggaaatt gtcgaagaac tgctcaagaa tggggcagac     900

atgaacgccc aggacaagtt cggcaagacc accttcgaca tcagcaccga caacggcaac     960

gaggacctgg ccgagatcct gcagaaactg tga                                  993


<210> 251
<211> 1008
<212> DNA
<213> Artificial Sequence


<220> 
<223> HA_K19_linker_UBE2B

<400> 251
tatccctacg acgtgcccga ttatgccgac ctgggcaaga agctgctgga agccgctaga      60

gccggccagg atgatgaagt gcggatcctg atggccaacg gcgccgatgt gaatgcctct     120

gatagatggg gctggacccc tctgcatctg gctgcttggt ggggacacct ggaaatcgtg     180

gaagtgctgc tgaagagagg ggccgacgtt tcagccgctg atctgcatgg acagagccca     240

ctgcatctcg ccgccatggt tggacacctt gagattgtcg aggtcctgct gaagtatggc     300

gctgacgtga acgccaagga caccatggga gccacaccac ttcatctggc cgctagatct     360

ggccatctgg aaattgtcga agaactgctc aagaatgggg ccgatatgaa cgcccaggat     420

aagttcggca agaccacctt cgacatcagc accgacaacg gcaacgagga cctggccgag     480

atcctgcaga aactgcttga aggcggcgga ggatctggcg gaggtggaag cggaggcggt     540

ggaagctcta gatctacccc tgctcggcgg agactgatgc gggacttcaa gagactgcaa     600

gaggaccctc ctgtgggagt gtctggcgcc cctagcgaga acaacatcat gcagtggaac     660

gccgtgatct tcggccctga gggcacccct tttgaggacg gcaccttcaa gctggtcatc     720

gagttcagcg aggaataccc caacaagcct cctaccgtgc ggttcctgag caagatgttt     780

caccccaacg tgtacgccga cggcagcatc tgtctggaca tcctccagaa cagatggtcc     840

ccaacctacg atgtgtccag catcctgacc agcatccaga gcctgctgga cgagcctaat     900

cctaacagcc ccgccaattc tcaggccgct cagctgtacc aagagaacaa gcgcgagtac     960

gagaagcggg tgtccgccat cgttgagcag agctggaacg acagctga                 1008


<210> 252
<211> 1008
<212> DNA
<213> Artificial Sequence


<220> 
<223> HA_UBE2B_linker_K19

<400> 252
tatccctacg acgtgcccga ttatgccagc acaccagctc gtcggagact gatgcgggac      60

ttcaagcggc tgcaagagga tccacctgtg ggagtttctg gcgcccctag cgagaacaac     120

atcatgcagt ggaacgccgt gatcttcggc cctgagggca ccccttttga ggacggcacc     180

ttcaagctgg tcatcgagtt cagcgaggaa taccccaaca agcctcctac cgtgcggttc     240

ctgagcaaga tgtttcaccc caacgtgtac gccgacggca gcatctgtct ggacatcctg     300

cagaacagat ggtccccaac ctacgatgtg tccagcatcc tgaccagcat ccagagcctg     360

ctggacgagc ccaatcctaa cagccctgcc aattctcagg ccgctcagct gtaccaagag     420

aacaagcgcg agtacgagaa gcgggtgtcc gccatcgttg agcagagctg gaacgatagc     480

cttgaaggcg gcggaggatc tggcggaggt ggaagcggag gcggtggatc ttctagagat     540

ctgggcaaga agctgctgga agccgctaga gccggccagg atgatgaagt gcggatcctg     600

atggccaacg gcgccgatgt gaatgcctct gatagatggg gctggacccc tctgcatctg     660

gctgcttggt ggggacacct ggaaatcgtg gaagtgctgc tgaagagagg ggccgacgtt     720

tcagccgctg atctgcatgg acagagccct ctgcaccttg ccgccatggt tggacacctt     780

gagattgtcg aggtcctgct gaagtatggc gctgacgtga acgccaagga caccatggga     840

gccacaccac ttcatctggc cgccagaagc ggccatctgg aaattgtcga agaactgctc     900

aagaatgggg ccgatatgaa cgcccaggat aagttcggca agaccacctt cgacatcagc     960

accgacaacg gcaatgagga cctggccgag atcctgcaaa agctctga                 1008


<210> 253
<211> 330
<212> PRT
<213> Artificial Sequence


<220> 
<223> HA_K19_linker_UBE2D1

<400> 253
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asp Leu Gly Lys Lys Leu Leu 
1               5                   10                  15      
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala 
            20                  25                  30          
Asn Gly Ala Asp Val Asn Ala Ser Asp Arg Trp Gly Trp Thr Pro Leu 
        35                  40                  45              
His Leu Ala Ala Trp Trp Gly His Leu Glu Ile Val Glu Val Leu Leu 
    50                  55                  60                  
Lys Arg Gly Ala Asp Val Ser Ala Ala Asp Leu His Gly Gln Ser Pro 
65                  70                  75                  80  
Leu His Leu Ala Ala Met Val Gly His Leu Glu Ile Val Glu Val Leu 
                85                  90                  95      
Leu Lys Tyr Gly Ala Asp Val Asn Ala Lys Asp Thr Met Gly Ala Thr 
            100                 105                 110         
Pro Leu His Leu Ala Ala Arg Ser Gly His Leu Glu Ile Val Glu Glu 
        115                 120                 125             
Leu Leu Lys Asn Gly Ala Asp Met Asn Ala Gln Asp Lys Phe Gly Lys 
    130                 135                 140                 
Thr Thr Phe Asp Ile Ser Thr Asp Asn Gly Asn Glu Asp Leu Ala Glu 
145                 150                 155                 160 
Ile Leu Gln Lys Leu Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     
Ser Gly Gly Gly Gly Ser Ser Arg Ala Leu Lys Arg Ile Gln Lys Glu 
            180                 185                 190         
Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly Pro 
        195                 200                 205             
Val Gly Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro Pro 
    210                 215                 220                 
Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe Pro 
225                 230                 235                 240 
Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys Ile 
                245                 250                 255     
Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile Leu 
            260                 265                 270         
Arg Ser Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu Ser 
        275                 280                 285             
Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val Pro 
    290                 295                 300                 
Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg His 
305                 310                 315                 320 
Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met 
                325                 330 

<210> 254
<211> 330
<212> PRT
<213> Artificial Sequence


<220> 
<223> HA_UBE2D1_linker_K19

<400> 254
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Leu Lys Arg Ile Gln Lys 
1               5                   10                  15      
Glu Leu Ser Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly 
            20                  25                  30          
Pro Val Gly Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro 
        35                  40                  45              
Pro Asp Ser Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe 
    50                  55                  60                  
Pro Thr Asp Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys 
65                  70                  75                  80  
Ile Tyr His Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile 
                85                  90                  95      
Leu Arg Ser Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu 
            100                 105                 110         
Ser Ile Cys Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val 
        115                 120                 125             
Pro Asp Ile Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg 
    130                 135                 140                 
His Ala Arg Glu Trp Thr Gln Lys Tyr Ala Met Leu Glu Gly Gly Gly 
145                 150                 155                 160 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Asp Leu 
                165                 170                 175     
Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val 
            180                 185                 190         
Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Ser Asp Arg Trp 
        195                 200                 205             
Gly Trp Thr Pro Leu His Leu Ala Ala Trp Trp Gly His Leu Glu Ile 
    210                 215                 220                 
Val Glu Val Leu Leu Lys Arg Gly Ala Asp Val Ser Ala Ala Asp Leu 
225                 230                 235                 240 
His Gly Gln Ser Pro Leu His Leu Ala Ala Met Val Gly His Leu Glu 
                245                 250                 255     
Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Lys Asp 
            260                 265                 270         
Thr Met Gly Ala Thr Pro Leu His Leu Ala Ala Arg Ser Gly His Leu 
        275                 280                 285             
Glu Ile Val Glu Glu Leu Leu Lys Asn Gly Ala Asp Met Asn Ala Gln 
    290                 295                 300                 
Asp Lys Phe Gly Lys Thr Thr Phe Asp Ile Ser Thr Asp Asn Gly Asn 
305                 310                 315                 320 
Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu 
                325                 330 

<210> 255
<211> 335
<212> PRT
<213> Artificial Sequence


<220> 
<223> HA_K19_linker_UBE2B

<400> 255
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asp Leu Gly Lys Lys Leu Leu 
1               5                   10                  15      
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala 
            20                  25                  30          
Asn Gly Ala Asp Val Asn Ala Ser Asp Arg Trp Gly Trp Thr Pro Leu 
        35                  40                  45              
His Leu Ala Ala Trp Trp Gly His Leu Glu Ile Val Glu Val Leu Leu 
    50                  55                  60                  
Lys Arg Gly Ala Asp Val Ser Ala Ala Asp Leu His Gly Gln Ser Pro 
65                  70                  75                  80  
Leu His Leu Ala Ala Met Val Gly His Leu Glu Ile Val Glu Val Leu 
                85                  90                  95      
Leu Lys Tyr Gly Ala Asp Val Asn Ala Lys Asp Thr Met Gly Ala Thr 
            100                 105                 110         
Pro Leu His Leu Ala Ala Arg Ser Gly His Leu Glu Ile Val Glu Glu 
        115                 120                 125             
Leu Leu Lys Asn Gly Ala Asp Met Asn Ala Gln Asp Lys Phe Gly Lys 
    130                 135                 140                 
Thr Thr Phe Asp Ile Ser Thr Asp Asn Gly Asn Glu Asp Leu Ala Glu 
145                 150                 155                 160 
Ile Leu Gln Lys Leu Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     
Ser Gly Gly Gly Gly Ser Ser Arg Ser Thr Pro Ala Arg Arg Arg Leu 
            180                 185                 190         
Met Arg Asp Phe Lys Arg Leu Gln Glu Asp Pro Pro Val Gly Val Ser 
        195                 200                 205             
Gly Ala Pro Ser Glu Asn Asn Ile Met Gln Trp Asn Ala Val Ile Phe 
    210                 215                 220                 
Gly Pro Glu Gly Thr Pro Phe Glu Asp Gly Thr Phe Lys Leu Val Ile 
225                 230                 235                 240 
Glu Phe Ser Glu Glu Tyr Pro Asn Lys Pro Pro Thr Val Arg Phe Leu 
                245                 250                 255     
Ser Lys Met Phe His Pro Asn Val Tyr Ala Asp Gly Ser Ile Cys Leu 
            260                 265                 270         
Asp Ile Leu Gln Asn Arg Trp Ser Pro Thr Tyr Asp Val Ser Ser Ile 
        275                 280                 285             
Leu Thr Ser Ile Gln Ser Leu Leu Asp Glu Pro Asn Pro Asn Ser Pro 
    290                 295                 300                 
Ala Asn Ser Gln Ala Ala Gln Leu Tyr Gln Glu Asn Lys Arg Glu Tyr 
305                 310                 315                 320 
Glu Lys Arg Val Ser Ala Ile Val Glu Gln Ser Trp Asn Asp Ser 
                325                 330                 335 

<210> 256
<211> 335
<212> PRT
<213> Artificial Sequence


<220> 
<223> HA_UBE2B_linker_K19

<400> 256
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Thr Pro Ala Arg Arg Arg 
1               5                   10                  15      
Leu Met Arg Asp Phe Lys Arg Leu Gln Glu Asp Pro Pro Val Gly Val 
            20                  25                  30          
Ser Gly Ala Pro Ser Glu Asn Asn Ile Met Gln Trp Asn Ala Val Ile 
        35                  40                  45              
Phe Gly Pro Glu Gly Thr Pro Phe Glu Asp Gly Thr Phe Lys Leu Val 
    50                  55                  60                  
Ile Glu Phe Ser Glu Glu Tyr Pro Asn Lys Pro Pro Thr Val Arg Phe 
65                  70                  75                  80  
Leu Ser Lys Met Phe His Pro Asn Val Tyr Ala Asp Gly Ser Ile Cys 
                85                  90                  95      
Leu Asp Ile Leu Gln Asn Arg Trp Ser Pro Thr Tyr Asp Val Ser Ser 
            100                 105                 110         
Ile Leu Thr Ser Ile Gln Ser Leu Leu Asp Glu Pro Asn Pro Asn Ser 
        115                 120                 125             
Pro Ala Asn Ser Gln Ala Ala Gln Leu Tyr Gln Glu Asn Lys Arg Glu 
    130                 135                 140                 
Tyr Glu Lys Arg Val Ser Ala Ile Val Glu Gln Ser Trp Asn Asp Ser 
145                 150                 155                 160 
Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     
Ser Ser Arg Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly 
            180                 185                 190         
Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn 
        195                 200                 205             
Ala Ser Asp Arg Trp Gly Trp Thr Pro Leu His Leu Ala Ala Trp Trp 
    210                 215                 220                 
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Arg Gly Ala Asp Val 
225                 230                 235                 240 
Ser Ala Ala Asp Leu His Gly Gln Ser Pro Leu His Leu Ala Ala Met 
                245                 250                 255     
Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
            260                 265                 270         
Val Asn Ala Lys Asp Thr Met Gly Ala Thr Pro Leu His Leu Ala Ala 
        275                 280                 285             
Arg Ser Gly His Leu Glu Ile Val Glu Glu Leu Leu Lys Asn Gly Ala 
    290                 295                 300                 
Asp Met Asn Ala Gln Asp Lys Phe Gly Lys Thr Thr Phe Asp Ile Ser 
305                 310                 315                 320 
Thr Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu 
                325                 330                 335 

<210> 257
<211> 94
<212> PRT
<213> Artificial Sequence


<220> 
<223> aCS3 (K7Q/K55Y/K64H/V33R)

<400> 257
Val Ser Ser Val Pro Thr Gln Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      
Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr 
            20                  25                  30          
Arg Ile Thr Tyr Gly Glu Thr Gly His Trp Pro Trp Val Trp Gln Glu 
        35                  40                  45              
Phe Glu Val Pro Gly Ser Tyr Ser Thr Ala Thr Ile Ser Gly Leu His 
    50                  55                  60                  
Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser 
65                  70                  75                  80  
Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  

<210> 258
<211> 810
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2D1(C85A)_ Linker2_aCS3(K7Q,K55Y,K64H)_HA

<400> 258
gccttgaagc ggattcagaa agagctgagc gacctgcaga gggaccctcc tgctcactgt      60

tctgctggac ccgtgggaga tgacctgttc cactggcaag ccaccatcat gggccctcca     120

gatagcgcct atcaaggcgg cgtgttcttc ctgaccgtgc acttccccac agactacccc     180

ttcaagcctc ctaagatcgc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatcg ccctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gatatcgccc agatctacaa gagcgacaaa gagaagtaca accggcacgc cagagagtgg     420

acccagaaat acgctatgct ggaaggcggc ggaggatctg gcggaggcgg tagcggtggt     480

ggtggatctt ctagagtgtc cagcgtgccc acacagctgg aagtggttgc cgccacacct     540

acaagcctgc tgatctcttg ggatgcccct gccgtgacag tggactacta cgtgatcacc     600

tacggcgaga caggccactg gccttgggtc tggcaagagt ttgaagtgcc cggcagctac     660

agcaccgcca caatttctgg actgcacccc ggcgtggact acaccatcac agtgtacgcc     720

ggctcctaca gcagctacta ctactatggc agccccatca gcatcaacta ccggacaggc     780

ggctacccct acgacgtgcc agattatgct                                      810


<210> 259
<211> 810
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2D1_ Linker2_aCS3(K7Q,K55Y,K64H,V33R) _HA

<400> 259
gccttgaagc ggattcagaa agagctgagc gacctgcaga gggaccctcc tgctcactgt      60

tctgctggac ccgtgggaga tgacctgttc cactggcaag ccaccatcat gggccctcca     120

gatagcgcct atcaaggcgg cgtgttcttc ctgaccgtgc acttccccac agactacccc     180

ttcaagcctc ctaagatcgc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gatatcgccc agatctacaa gagcgacaaa gagaagtaca accggcacgc cagagagtgg     420

acccagaaat acgctatgct ggaaggcggc ggaggatctg gcggaggcgg tagcggtggt     480

ggtggatctt ctagagtgtc cagcgtgccc acacagctgg aagtggttgc cgccacacct     540

acaagcctgc tgatctcttg ggatgcccct gccgtgacag tggactacta ccggatcacc     600

tacggcgaga caggccactg gccttgggtc tggcaagagt ttgaagtgcc cggcagctac     660

agcaccgcca caatttctgg actgcacccc ggcgtggact acaccatcac agtgtacgcc     720

ggctcctaca gcagctacta ctactatggc agccccatca gcatcaacta ccggacaggc     780

ggctacccct acgacgtgcc agattatgct                                      810


<210> 260
<211> 810
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2D1(C85A)_ Linker2_aCS3(K7Q,K55Y,K64H,V33R)_HA

<400> 260
gccttgaagc ggattcagaa agagctgagc gacctgcaga gggaccctcc tgctcactgt      60

tctgctggac ccgtgggaga tgacctgttc cactggcaag ccaccatcat gggccctcca     120

gatagcgcct atcaaggcgg cgtgttcttc ctgaccgtgc acttccccac agactacccc     180

ttcaagcctc ctaagatcgc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatcg ccctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gatatcgccc agatctacaa gagcgacaaa gagaagtaca accggcacgc cagagagtgg     420

acccagaaat acgctatgct ggaaggcggc ggaggatctg gcggaggcgg tagcggtggt     480

ggtggatctt ctagagtgtc cagcgtgccc acacagctgg aagtggttgc cgccacacct     540

acaagcctgc tgatctcttg ggatgcccct gccgtgacag tggactacta ccggatcacc     600

tacggcgaga caggccactg gccttgggtc tggcaagagt ttgaagtgcc cggcagctac     660

agcaccgcca caatttctgg actgcacccc ggcgtggact acaccatcac agtgtacgcc     720

ggctcctaca gcagctacta ctactatggc agccccatca gcatcaacta ccggacaggc     780

ggctacccct acgacgtgcc agattatgct                                      810


<210> 261
<211> 810
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2D1(F62A)_ Linker2_aCS3(K7Q,K55Y,K64H)_HA

<400> 261
gccttgaagc ggattcagaa agagctgagc gacctgcaga gggaccctcc tgctcactgt      60

tctgctggac ccgtgggaga tgacctgttc cactggcaag ccaccatcat gggccctcca     120

gatagcgcct atcaaggcgg cgtgttcttc ctgaccgtgc acttccccac agactacccc     180

gccaagcctc ctaagatcgc cttcaccacc aagatctatc accccaacat caacagcaac     240

ggcagcatct gcctggacat cctgagaagc caatggtccc ctgctctgac cgtgtccaag     300

gtgctgctga gcatctgcag cctgctgtgc gaccccaatc ctgacgatcc tctggtgcct     360

gatatcgccc agatctacaa gagcgacaaa gagaagtaca accggcacgc cagagagtgg     420

acccagaaat acgctatgct ggaaggcggc ggaggatctg gcggaggcgg tagcggtggt     480

ggtggatctt ctagagtgtc cagcgtgccc acacagctgg aagtggttgc cgccacacct     540

acaagcctgc tgatctcttg ggatgcccct gccgtgacag tggactacta cgtgatcacc     600

tacggcgaga caggccactg gccttgggtc tggcaagagt ttgaagtgcc cggcagctac     660

agcaccgcca caatttctgg actgcacccc ggcgtggact acaccatcac agtgtacgcc     720

ggctcctaca gcagctacta ctactatggc agccccatca gcatcaacta ccggacaggc     780

ggctacccct acgacgtgcc agattatgct                                      810


<210> 262
<211> 825
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2B_ Linker2_aCS3(K7Q,K55Y,K64H)_HA

<400> 262
agcacaccag ctcggcggag actgatgaga gacttcaagc ggctgcaaga ggaccctcct      60

gtgggagttt ctggcgcccc tagcgagaac aacatcatgc agtggaacgc cgtgatcttc     120

ggccctgagg gcaccccttt tgaggacggc accttcaagc tggtcatcga gttcagcgag     180

gaatacccca acaagcctcc taccgtgcgg ttcctgagca agatgtttca ccccaacgtg     240

tacgccgacg gcagcatctg tctggacatc ctgcagaaca gatggtcccc aacctacgat     300

gtgtccagca tcctgaccag catccagagc ctgctggacg agcccaatcc taacagccct     360

gccaattctc aggccgctca gctgtaccaa gagaacaagc gcgagtacga gaagcgggtg     420

tccgccatcg ttgagcagag ctggaatgac agcctggaag gcggcggagg atctggcgga     480

ggcggtagcg gtggtggtgg atcttctaga gtgtccagcg tgcccacaca gctggaagtg     540

gttgccgcca cacctacaag cctgctgatc tcttgggatg cccctgccgt gacagtggac     600

tactacgtga tcacctacgg cgagacaggc cactggcctt gggtctggca agagtttgaa     660

gtgcccggca gctacagcac cgccacaatt tctggactgc accccggcgt ggactacacc     720

atcacagtgt acgccggctc ctacagcagc tactactact atggcagccc catcagcatc     780

aactaccgga caggcggcta cccctacgac gtgccagatt atgct                     825


<210> 263
<211> 825
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2B(C88A)_ Linker2_aCS3(K7Q,K55Y,K64H)_HA

<400> 263
agcacaccag ctcggcggag actgatgaga gacttcaagc ggctgcaaga ggaccctcct      60

gtgggagttt ctggcgcccc tagcgagaac aacatcatgc agtggaacgc cgtgatcttc     120

ggccctgagg gcaccccttt tgaggacggc accttcaagc tggtcatcga gttcagcgag     180

gaatacccca acaagcctcc taccgtgcgg ttcctgagca agatgtttca ccccaacgtg     240

tacgccgacg gcagcatcgc gctggacatc ctgcagaaca gatggtcccc aacctacgat     300

gtgtccagca tcctgaccag catccagagc ctgctggacg agcccaatcc taacagccct     360

gccaattctc aggccgctca gctgtaccaa gagaacaagc gcgagtacga gaagcgggtg     420

tccgccatcg ttgagcagag ctggaatgac agcctggaag gcggcggagg atctggcgga     480

ggcggtagcg gtggtggtgg atcttctaga gtgtccagcg tgcccacaca gctggaagtg     540

gttgccgcca cacctacaag cctgctgatc tcttgggatg cccctgccgt gacagtggac     600

tactacgtga tcacctacgg cgagacaggc cactggcctt gggtctggca agagtttgaa     660

gtgcccggca gctacagcac cgccacaatt tctggactgc accccggcgt ggactacacc     720

atcacagtgt acgccggctc ctacagcagc tactactact atggcagccc catcagcatc     780

aactaccgga caggcggcta cccctacgac gtgccagatt atgct                     825


<210> 264
<211> 825
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2B_ Linker2_aCS3(K7Q,K55Y,K64H,V33R)_HA

<400> 264
agcacaccag ctcggcggag actgatgaga gacttcaagc ggctgcaaga ggaccctcct      60

gtgggagttt ctggcgcccc tagcgagaac aacatcatgc agtggaacgc cgtgatcttc     120

ggccctgagg gcaccccttt tgaggacggc accttcaagc tggtcatcga gttcagcgag     180

gaatacccca acaagcctcc taccgtgcgg ttcctgagca agatgtttca ccccaacgtg     240

tacgccgacg gcagcatctg tctggacatc ctgcagaaca gatggtcccc aacctacgat     300

gtgtccagca tcctgaccag catccagagc ctgctggacg agcccaatcc taacagccct     360

gccaattctc aggccgctca gctgtaccaa gagaacaagc gcgagtacga gaagcgggtg     420

tccgccatcg ttgagcagag ctggaatgac agcctggaag gcggcggagg atctggcgga     480

ggcggtagcg gtggtggtgg atcttctaga gtgtccagcg tgcccacaca gctggaagtg     540

gttgccgcca cacctacaag cctgctgatc tcttgggatg cccctgccgt gacagtggac     600

tactaccgga tcacctacgg cgagacaggc cactggcctt gggtctggca agagtttgaa     660

gtgcccggca gctacagcac cgccacaatt tctggactgc accccggcgt ggactacacc     720

atcacagtgt acgccggctc ctacagcagc tactactact atggcagccc catcagcatc     780

aactaccgga caggcggcta cccctacgac gtgccagatt atgct                     825


<210> 265
<211> 825
<212> DNA
<213> Artificial Sequence


<220> 
<223> UBE2B(C88A)_ Linker2_aCS3(K7Q,K55Y,K64H,V33R)_HA

<400> 265
agcacaccag ctcggcggag actgatgaga gacttcaagc ggctgcaaga ggaccctcct      60

gtgggagttt ctggcgcccc tagcgagaac aacatcatgc agtggaacgc cgtgatcttc     120

ggccctgagg gcaccccttt tgaggacggc accttcaagc tggtcatcga gttcagcgag     180

gaatacccca acaagcctcc taccgtgcgg ttcctgagca agatgtttca ccccaacgtg     240

tacgccgacg gcagcatcgc gctggacatc ctgcagaaca gatggtcccc aacctacgat     300

gtgtccagca tcctgaccag catccagagc ctgctggacg agcccaatcc taacagccct     360

gccaattctc aggccgctca gctgtaccaa gagaacaagc gcgagtacga gaagcgggtg     420

tccgccatcg ttgagcagag ctggaatgac agcctggaag gcggcggagg atctggcgga     480

ggcggtagcg gtggtggtgg atcttctaga gtgtccagcg tgcccacaca gctggaagtg     540

gttgccgcca cacctacaag cctgctgatc tcttgggatg cccctgccgt gacagtggac     600

tactaccgga tcacctacgg cgagacaggc cactggcctt gggtctggca agagtttgaa     660

gtgcccggca gctacagcac cgccacaatt tctggactgc accccggcgt ggactacacc     720

atcacagtgt acgccggctc ctacagcagc tactactact atggcagccc catcagcatc     780

aactaccgga caggcggcta cccctacgac gtgccagatt atgct                     825


<210> 266
<211> 270
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1(C85A)_ Linker2_aCS3(K7Q,K55Y,K64H)_HA

<400> 266
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Ala Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 
Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr Gln Leu Glu Val Val 
                165                 170                 175     
Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val 
            180                 185                 190         
Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro 
        195                 200                 205             
Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser Tyr Ser Thr Ala Thr 
    210                 215                 220                 
Ile Ser Gly Leu His Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala 
225                 230                 235                 240 
Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn 
                245                 250                 255     
Tyr Arg Thr Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            260                 265                 270 

<210> 267
<211> 270
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1_Linker2_aCS3(K7Q,K55Y,K64H,V33R) _HA

<400> 267
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 
Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr Gln Leu Glu Val Val 
                165                 170                 175     
Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val 
            180                 185                 190         
Thr Val Asp Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly His Trp Pro 
        195                 200                 205             
Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser Tyr Ser Thr Ala Thr 
    210                 215                 220                 
Ile Ser Gly Leu His Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala 
225                 230                 235                 240 
Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn 
                245                 250                 255     
Tyr Arg Thr Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            260                 265                 270 

<210> 268
<211> 270
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1(C85A)_ Linker2_aCS3(K7Q,K55Y,K64H,V33R)_HA

<400> 268
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Phe Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Ala Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 
Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr Gln Leu Glu Val Val 
                165                 170                 175     
Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val 
            180                 185                 190         
Thr Val Asp Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly His Trp Pro 
        195                 200                 205             
Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser Tyr Ser Thr Ala Thr 
    210                 215                 220                 
Ile Ser Gly Leu His Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala 
225                 230                 235                 240 
Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn 
                245                 250                 255     
Tyr Arg Thr Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            260                 265                 270 

<210> 269
<211> 270
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1(F62A)_ Linker2_aCS3(K7Q,K55Y,K64H)_HA

<400> 269
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Ala Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 
Ala Met Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 
Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr Gln Leu Glu Val Val 
                165                 170                 175     
Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val 
            180                 185                 190         
Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu Thr Gly His Trp Pro 
        195                 200                 205             
Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser Tyr Ser Thr Ala Thr 
    210                 215                 220                 
Ile Ser Gly Leu His Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala 
225                 230                 235                 240 
Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser Pro Ile Ser Ile Asn 
                245                 250                 255     
Tyr Arg Thr Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            260                 265                 270 

<210> 270
<211> 275
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2B_ Linker2_aCS3(K7Q,K55Y,K64H)_HA

<400> 270
Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Leu Gln 
1               5                   10                  15      
Glu Asp Pro Pro Val Gly Val Ser Gly Ala Pro Ser Glu Asn Asn Ile 
            20                  25                  30          
Met Gln Trp Asn Ala Val Ile Phe Gly Pro Glu Gly Thr Pro Phe Glu 
        35                  40                  45              
Asp Gly Thr Phe Lys Leu Val Ile Glu Phe Ser Glu Glu Tyr Pro Asn 
    50                  55                  60                  
Lys Pro Pro Thr Val Arg Phe Leu Ser Lys Met Phe His Pro Asn Val 
65                  70                  75                  80  
Tyr Ala Asp Gly Ser Ile Cys Leu Asp Ile Leu Gln Asn Arg Trp Ser 
                85                  90                  95      
Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr Ser Ile Gln Ser Leu Leu 
            100                 105                 110         
Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn Ser Gln Ala Ala Gln Leu 
        115                 120                 125             
Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys Arg Val Ser Ala Ile Val 
    130                 135                 140                 
Glu Gln Ser Trp Asn Asp Ser Leu Glu Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 
Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr 
                165                 170                 175     
Gln Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp 
            180                 185                 190         
Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu 
        195                 200                 205             
Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser 
    210                 215                 220                 
Tyr Ser Thr Ala Thr Ile Ser Gly Leu His Pro Gly Val Asp Tyr Thr 
225                 230                 235                 240 
Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser 
                245                 250                 255     
Pro Ile Ser Ile Asn Tyr Arg Thr Gly Gly Tyr Pro Tyr Asp Val Pro 
            260                 265                 270         
Asp Tyr Ala 
        275 

<210> 271
<211> 275
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2B(C88A)_Linker2_aCS3(K7Q,K55Y,K64H)_HA

<400> 271
Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Leu Gln 
1               5                   10                  15      
Glu Asp Pro Pro Val Gly Val Ser Gly Ala Pro Ser Glu Asn Asn Ile 
            20                  25                  30          
Met Gln Trp Asn Ala Val Ile Phe Gly Pro Glu Gly Thr Pro Phe Glu 
        35                  40                  45              
Asp Gly Thr Phe Lys Leu Val Ile Glu Phe Ser Glu Glu Tyr Pro Asn 
    50                  55                  60                  
Lys Pro Pro Thr Val Arg Phe Leu Ser Lys Met Phe His Pro Asn Val 
65                  70                  75                  80  
Tyr Ala Asp Gly Ser Ile Ala Leu Asp Ile Leu Gln Asn Arg Trp Ser 
                85                  90                  95      
Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr Ser Ile Gln Ser Leu Leu 
            100                 105                 110         
Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn Ser Gln Ala Ala Gln Leu 
        115                 120                 125             
Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys Arg Val Ser Ala Ile Val 
    130                 135                 140                 
Glu Gln Ser Trp Asn Asp Ser Leu Glu Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 
Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr 
                165                 170                 175     
Gln Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp 
            180                 185                 190         
Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Val Ile Thr Tyr Gly Glu 
        195                 200                 205             
Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser 
    210                 215                 220                 
Tyr Ser Thr Ala Thr Ile Ser Gly Leu His Pro Gly Val Asp Tyr Thr 
225                 230                 235                 240 
Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser 
                245                 250                 255     
Pro Ile Ser Ile Asn Tyr Arg Thr Gly Gly Tyr Pro Tyr Asp Val Pro 
            260                 265                 270         
Asp Tyr Ala 
        275 

<210> 272
<211> 275
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2B_Linker2_aCS3(K7Q,K55Y,K64H,V33R)_HA

<400> 272
Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Leu Gln 
1               5                   10                  15      
Glu Asp Pro Pro Val Gly Val Ser Gly Ala Pro Ser Glu Asn Asn Ile 
            20                  25                  30          
Met Gln Trp Asn Ala Val Ile Phe Gly Pro Glu Gly Thr Pro Phe Glu 
        35                  40                  45              
Asp Gly Thr Phe Lys Leu Val Ile Glu Phe Ser Glu Glu Tyr Pro Asn 
    50                  55                  60                  
Lys Pro Pro Thr Val Arg Phe Leu Ser Lys Met Phe His Pro Asn Val 
65                  70                  75                  80  
Tyr Ala Asp Gly Ser Ile Cys Leu Asp Ile Leu Gln Asn Arg Trp Ser 
                85                  90                  95      
Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr Ser Ile Gln Ser Leu Leu 
            100                 105                 110         
Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn Ser Gln Ala Ala Gln Leu 
        115                 120                 125             
Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys Arg Val Ser Ala Ile Val 
    130                 135                 140                 
Glu Gln Ser Trp Asn Asp Ser Leu Glu Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 
Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr 
                165                 170                 175     
Gln Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp 
            180                 185                 190         
Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Arg Ile Thr Tyr Gly Glu 
        195                 200                 205             
Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser 
    210                 215                 220                 
Tyr Ser Thr Ala Thr Ile Ser Gly Leu His Pro Gly Val Asp Tyr Thr 
225                 230                 235                 240 
Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser 
                245                 250                 255     
Pro Ile Ser Ile Asn Tyr Arg Thr Gly Gly Tyr Pro Tyr Asp Val Pro 
            260                 265                 270         
Asp Tyr Ala 
        275 

<210> 273
<211> 275
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2B(C88A)_Linker2_aCS3(K7Q,K55Y,K64H,V33R)_HA

<400> 273
Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Leu Gln 
1               5                   10                  15      
Glu Asp Pro Pro Val Gly Val Ser Gly Ala Pro Ser Glu Asn Asn Ile 
            20                  25                  30          
Met Gln Trp Asn Ala Val Ile Phe Gly Pro Glu Gly Thr Pro Phe Glu 
        35                  40                  45              
Asp Gly Thr Phe Lys Leu Val Ile Glu Phe Ser Glu Glu Tyr Pro Asn 
    50                  55                  60                  
Lys Pro Pro Thr Val Arg Phe Leu Ser Lys Met Phe His Pro Asn Val 
65                  70                  75                  80  
Tyr Ala Asp Gly Ser Ile Ala Leu Asp Ile Leu Gln Asn Arg Trp Ser 
                85                  90                  95      
Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr Ser Ile Gln Ser Leu Leu 
            100                 105                 110         
Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn Ser Gln Ala Ala Gln Leu 
        115                 120                 125             
Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys Arg Val Ser Ala Ile Val 
    130                 135                 140                 
Glu Gln Ser Trp Asn Asp Ser Leu Glu Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 
Gly Gly Ser Gly Gly Gly Gly Ser Ser Arg Val Ser Ser Val Pro Thr 
                165                 170                 175     
Gln Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp 
            180                 185                 190         
Asp Ala Pro Ala Val Thr Val Asp Tyr Tyr Arg Ile Thr Tyr Gly Glu 
        195                 200                 205             
Thr Gly His Trp Pro Trp Val Trp Gln Glu Phe Glu Val Pro Gly Ser 
    210                 215                 220                 
Tyr Ser Thr Ala Thr Ile Ser Gly Leu His Pro Gly Val Asp Tyr Thr 
225                 230                 235                 240 
Ile Thr Val Tyr Ala Gly Ser Tyr Ser Ser Tyr Tyr Tyr Tyr Gly Ser 
                245                 250                 255     
Pro Ile Ser Ile Asn Tyr Arg Thr Gly Gly Tyr Pro Tyr Asp Val Pro 
            260                 265                 270         
Asp Tyr Ala 
        275 

<210> 274
<211> 333
<212> PRT
<213> Artificial Sequence


<220> 
<223> HA_E3_5_Linker2_UBE2B

<400> 274
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asp Leu Gly Lys Lys Leu Leu 
1               5                   10                  15      
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala 
            20                  25                  30          
Asn Gly Ala Asp Val Asn Ala Thr Asp Asn Asp Gly Tyr Thr Pro Leu 
        35                  40                  45              
His Leu Ala Ala Ser Asn Gly His Leu Glu Ile Val Glu Val Leu Leu 
    50                  55                  60                  
Lys Asn Gly Ala Asp Val Asn Ala Ser Asp Leu Thr Gly Ile Thr Pro 
65                  70                  75                  80  
Leu His Leu Ala Ala Ala Thr Gly His Leu Glu Ile Val Glu Val Leu 
                85                  90                  95      
Leu Lys His Gly Ala Asp Val Asn Ala Tyr Asp Asn Asp Gly His Thr 
            100                 105                 110         
Pro Leu His Leu Ala Ala Lys Tyr Gly His Leu Glu Ile Val Glu Val 
        115                 120                 125             
Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys 
    130                 135                 140                 
Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu 
145                 150                 155                 160 
Ile Leu Gln Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                165                 170                 175     
Gly Gly Gly Ser Ser Arg Ser Thr Pro Ala Arg Arg Arg Leu Met Arg 
            180                 185                 190         
Asp Phe Lys Arg Leu Gln Glu Asp Pro Pro Val Gly Val Ser Gly Ala 
        195                 200                 205             
Pro Ser Glu Asn Asn Ile Met Gln Trp Asn Ala Val Ile Phe Gly Pro 
    210                 215                 220                 
Glu Gly Thr Pro Phe Glu Asp Gly Thr Phe Lys Leu Val Ile Glu Phe 
225                 230                 235                 240 
Ser Glu Glu Tyr Pro Asn Lys Pro Pro Thr Val Arg Phe Leu Ser Lys 
                245                 250                 255     
Met Phe His Pro Asn Val Tyr Ala Asp Gly Ser Ile Cys Leu Asp Ile 
            260                 265                 270         
Leu Gln Asn Arg Trp Ser Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr 
        275                 280                 285             
Ser Ile Gln Ser Leu Leu Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn 
    290                 295                 300                 
Ser Gln Ala Ala Gln Leu Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys 
305                 310                 315                 320 
Arg Val Ser Ala Ile Val Glu Gln Ser Trp Asn Asp Ser 
                325                 330             

<210> 275
<211> 328
<212> PRT
<213> Artificial Sequence


<220> 
<223> HA_E3_5_Linker2_UBE2D1

<400> 275
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asp Leu Gly Lys Lys Leu Leu 
1               5                   10                  15      
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala 
            20                  25                  30          
Asn Gly Ala Asp Val Asn Ala Thr Asp Asn Asp Gly Tyr Thr Pro Leu 
        35                  40                  45              
His Leu Ala Ala Ser Asn Gly His Leu Glu Ile Val Glu Val Leu Leu 
    50                  55                  60                  
Lys Asn Gly Ala Asp Val Asn Ala Ser Asp Leu Thr Gly Ile Thr Pro 
65                  70                  75                  80  
Leu His Leu Ala Ala Ala Thr Gly His Leu Glu Ile Val Glu Val Leu 
                85                  90                  95      
Leu Lys His Gly Ala Asp Val Asn Ala Tyr Asp Asn Asp Gly His Thr 
            100                 105                 110         
Pro Leu His Leu Ala Ala Lys Tyr Gly His Leu Glu Ile Val Glu Val 
        115                 120                 125             
Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys 
    130                 135                 140                 
Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu 
145                 150                 155                 160 
Ile Leu Gln Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                165                 170                 175     
Gly Gly Gly Ser Ser Arg Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser 
            180                 185                 190         
Asp Leu Gln Arg Asp Pro Pro Ala His Cys Ser Ala Gly Pro Val Gly 
        195                 200                 205             
Asp Asp Leu Phe His Trp Gln Ala Thr Ile Met Gly Pro Pro Asp Ser 
    210                 215                 220                 
Ala Tyr Gln Gly Gly Val Phe Phe Leu Thr Val His Phe Pro Thr Asp 
225                 230                 235                 240 
Tyr Pro Phe Lys Pro Pro Lys Ile Ala Phe Thr Thr Lys Ile Tyr His 
                245                 250                 255     
Pro Asn Ile Asn Ser Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser 
            260                 265                 270         
Gln Trp Ser Pro Ala Leu Thr Val Ser Lys Val Leu Leu Ser Ile Cys 
        275                 280                 285             
Ser Leu Leu Cys Asp Pro Asn Pro Asp Asp Pro Leu Val Pro Asp Ile 
    290                 295                 300                 
Ala Gln Ile Tyr Lys Ser Asp Lys Glu Lys Tyr Asn Arg His Ala Arg 
305                 310                 315                 320 
Glu Trp Thr Gln Lys Tyr Ala Met 
                325             

<210> 276
<211> 396
<212> PRT
<213> Artificial Sequence


<220> 
<223> HA_VHL_Linker2_E3_5

<400> 276
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Met Pro Arg Arg Ala Glu 
1               5                   10                  15      
Asn Trp Asp Glu Ala Glu Val Gly Ala Glu Glu Ala Gly Val Glu Glu 
            20                  25                  30          
Tyr Gly Pro Glu Glu Asp Gly Gly Glu Glu Ser Gly Ala Glu Glu Ser 
        35                  40                  45              
Gly Pro Glu Glu Ser Gly Pro Glu Glu Leu Gly Ala Glu Glu Glu Met 
    50                  55                  60                  
Glu Val Gly Arg Pro Arg Pro Val Leu Arg Ser Val Asn Ser Arg Glu 
65                  70                  75                  80  
Pro Ser Gln Val Ile Phe Cys Asn Arg Ser Pro Arg Val Val Leu Pro 
                85                  90                  95      
Val Trp Leu Asn Phe Asp Gly Glu Pro Gln Pro Tyr Pro Thr Leu Pro 
            100                 105                 110         
Pro Gly Thr Gly Arg Arg Ile His Ser Tyr Arg Gly His Leu Trp Leu 
        115                 120                 125             
Phe Arg Asp Ala Gly Thr His Asp Gly Leu Leu Val Asn Gln Thr Glu 
    130                 135                 140                 
Leu Phe Val Pro Ser Leu Asn Val Asp Gly Gln Pro Ile Phe Ala Asn 
145                 150                 155                 160 
Ile Thr Leu Pro Val Tyr Thr Leu Lys Glu Arg Cys Leu Gln Val Val 
                165                 170                 175     
Arg Ser Leu Val Lys Pro Glu Asn Tyr Arg Arg Leu Asp Ile Val Arg 
            180                 185                 190         
Ser Leu Tyr Glu Asp Leu Glu Asp His Pro Asn Val Gln Lys Asp Leu 
        195                 200                 205             
Glu Arg Leu Thr Gln Glu Arg Ile Ala His Gln Arg Met Gly Asp Leu 
    210                 215                 220                 
Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 
Ser Arg Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
                245                 250                 255     
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            260                 265                 270         
Thr Asp Asn Asp Gly Tyr Thr Pro Leu His Leu Ala Ala Ser Asn Gly 
        275                 280                 285             
His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    290                 295                 300                 
Ala Ser Asp Leu Thr Gly Ile Thr Pro Leu His Leu Ala Ala Ala Thr 
305                 310                 315                 320 
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                325                 330                 335     
Asn Ala Tyr Asp Asn Asp Gly His Thr Pro Leu His Leu Ala Ala Lys 
            340                 345                 350         
Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp 
        355                 360                 365             
Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    370                 375                 380                 
Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln 
385                 390                 395     

<210> 277
<211> 398
<212> PRT
<213> Artificial Sequence


<220> 
<223> HA_VHL_Linker2_K19

<400> 277
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Met Pro Arg Arg Ala Glu 
1               5                   10                  15      
Asn Trp Asp Glu Ala Glu Val Gly Ala Glu Glu Ala Gly Val Glu Glu 
            20                  25                  30          
Tyr Gly Pro Glu Glu Asp Gly Gly Glu Glu Ser Gly Ala Glu Glu Ser 
        35                  40                  45              
Gly Pro Glu Glu Ser Gly Pro Glu Glu Leu Gly Ala Glu Glu Glu Met 
    50                  55                  60                  
Glu Val Gly Arg Pro Arg Pro Val Leu Arg Ser Val Asn Ser Arg Glu 
65                  70                  75                  80  
Pro Ser Gln Val Ile Phe Cys Asn Arg Ser Pro Arg Val Val Leu Pro 
                85                  90                  95      
Val Trp Leu Asn Phe Asp Gly Glu Pro Gln Pro Tyr Pro Thr Leu Pro 
            100                 105                 110         
Pro Gly Thr Gly Arg Arg Ile His Ser Tyr Arg Gly His Leu Trp Leu 
        115                 120                 125             
Phe Arg Asp Ala Gly Thr His Asp Gly Leu Leu Val Asn Gln Thr Glu 
    130                 135                 140                 
Leu Phe Val Pro Ser Leu Asn Val Asp Gly Gln Pro Ile Phe Ala Asn 
145                 150                 155                 160 
Ile Thr Leu Pro Val Tyr Thr Leu Lys Glu Arg Cys Leu Gln Val Val 
                165                 170                 175     
Arg Ser Leu Val Lys Pro Glu Asn Tyr Arg Arg Leu Asp Ile Val Arg 
            180                 185                 190         
Ser Leu Tyr Glu Asp Leu Glu Asp His Pro Asn Val Gln Lys Asp Leu 
        195                 200                 205             
Glu Arg Leu Thr Gln Glu Arg Ile Ala His Gln Arg Met Gly Asp Leu 
    210                 215                 220                 
Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 
Ser Arg Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
                245                 250                 255     
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            260                 265                 270         
Ser Asp Arg Trp Gly Trp Thr Pro Leu His Leu Ala Ala Trp Trp Gly 
        275                 280                 285             
His Leu Glu Ile Val Glu Val Leu Leu Lys Arg Gly Ala Asp Val Ser 
    290                 295                 300                 
Ala Ala Asp Leu His Gly Gln Ser Pro Leu His Leu Ala Ala Met Val 
305                 310                 315                 320 
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                325                 330                 335     
Asn Ala Lys Asp Thr Met Gly Ala Thr Pro Leu His Leu Ala Ala Arg 
            340                 345                 350         
Ser Gly His Leu Glu Ile Val Glu Glu Leu Leu Lys Asn Gly Ala Asp 
        355                 360                 365             
Met Asn Ala Gln Asp Lys Phe Gly Lys Thr Thr Phe Asp Ile Ser Thr 
    370                 375                 380                 
Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu 
385                 390                 395             

<210> 278
<211> 396
<212> PRT
<213> Artificial Sequence


<220> 
<223> HA_E3_5_Linker2_VHL

<400> 278
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asp Leu Gly Lys Lys Leu Leu 
1               5                   10                  15      
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala 
            20                  25                  30          
Asn Gly Ala Asp Val Asn Ala Thr Asp Asn Asp Gly Tyr Thr Pro Leu 
        35                  40                  45              
His Leu Ala Ala Ser Asn Gly His Leu Glu Ile Val Glu Val Leu Leu 
    50                  55                  60                  
Lys Asn Gly Ala Asp Val Asn Ala Ser Asp Leu Thr Gly Ile Thr Pro 
65                  70                  75                  80  
Leu His Leu Ala Ala Ala Thr Gly His Leu Glu Ile Val Glu Val Leu 
                85                  90                  95      
Leu Lys His Gly Ala Asp Val Asn Ala Tyr Asp Asn Asp Gly His Thr 
            100                 105                 110         
Pro Leu His Leu Ala Ala Lys Tyr Gly His Leu Glu Ile Val Glu Val 
        115                 120                 125             
Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys 
    130                 135                 140                 
Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu 
145                 150                 155                 160 
Ile Leu Gln Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                165                 170                 175     
Gly Gly Gly Ser Ser Arg Ala Met Pro Arg Arg Ala Glu Asn Trp Asp 
            180                 185                 190         
Glu Ala Glu Val Gly Ala Glu Glu Ala Gly Val Glu Glu Tyr Gly Pro 
        195                 200                 205             
Glu Glu Asp Gly Gly Glu Glu Ser Gly Ala Glu Glu Ser Gly Pro Glu 
    210                 215                 220                 
Glu Ser Gly Pro Glu Glu Leu Gly Ala Glu Glu Glu Met Glu Val Gly 
225                 230                 235                 240 
Arg Pro Arg Pro Val Leu Arg Ser Val Asn Ser Arg Glu Pro Ser Gln 
                245                 250                 255     
Val Ile Phe Cys Asn Arg Ser Pro Arg Val Val Leu Pro Val Trp Leu 
            260                 265                 270         
Asn Phe Asp Gly Glu Pro Gln Pro Tyr Pro Thr Leu Pro Pro Gly Thr 
        275                 280                 285             
Gly Arg Arg Ile His Ser Tyr Arg Gly His Leu Trp Leu Phe Arg Asp 
    290                 295                 300                 
Ala Gly Thr His Asp Gly Leu Leu Val Asn Gln Thr Glu Leu Phe Val 
305                 310                 315                 320 
Pro Ser Leu Asn Val Asp Gly Gln Pro Ile Phe Ala Asn Ile Thr Leu 
                325                 330                 335     
Pro Val Tyr Thr Leu Lys Glu Arg Cys Leu Gln Val Val Arg Ser Leu 
            340                 345                 350         
Val Lys Pro Glu Asn Tyr Arg Arg Leu Asp Ile Val Arg Ser Leu Tyr 
        355                 360                 365             
Glu Asp Leu Glu Asp His Pro Asn Val Gln Lys Asp Leu Glu Arg Leu 
    370                 375                 380                 
Thr Gln Glu Arg Ile Ala His Gln Arg Met Gly Asp 
385                 390                 395     

<210> 279
<211> 398
<212> PRT
<213> Artificial Sequence


<220> 
<223> HA_K19_Linker2_VHL

<400> 279
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asp Leu Gly Lys Lys Leu Leu 
1               5                   10                  15      
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala 
            20                  25                  30          
Asn Gly Ala Asp Val Asn Ala Ser Asp Arg Trp Gly Trp Thr Pro Leu 
        35                  40                  45              
His Leu Ala Ala Trp Trp Gly His Leu Glu Ile Val Glu Val Leu Leu 
    50                  55                  60                  
Lys Arg Gly Ala Asp Val Ser Ala Ala Asp Leu His Gly Gln Ser Pro 
65                  70                  75                  80  
Leu His Leu Ala Ala Met Val Gly His Leu Glu Ile Val Glu Val Leu 
                85                  90                  95      
Leu Lys Tyr Gly Ala Asp Val Asn Ala Lys Asp Thr Met Gly Ala Thr 
            100                 105                 110         
Pro Leu His Leu Ala Ala Arg Ser Gly His Leu Glu Ile Val Glu Glu 
        115                 120                 125             
Leu Leu Lys Asn Gly Ala Asp Met Asn Ala Gln Asp Lys Phe Gly Lys 
    130                 135                 140                 
Thr Thr Phe Asp Ile Ser Thr Asp Asn Gly Asn Glu Asp Leu Ala Glu 
145                 150                 155                 160 
Ile Leu Gln Lys Leu Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     
Ser Gly Gly Gly Gly Ser Ser Arg Ala Met Pro Arg Arg Ala Glu Asn 
            180                 185                 190         
Trp Asp Glu Ala Glu Val Gly Ala Glu Glu Ala Gly Val Glu Glu Tyr 
        195                 200                 205             
Gly Pro Glu Glu Asp Gly Gly Glu Glu Ser Gly Ala Glu Glu Ser Gly 
    210                 215                 220                 
Pro Glu Glu Ser Gly Pro Glu Glu Leu Gly Ala Glu Glu Glu Met Glu 
225                 230                 235                 240 
Val Gly Arg Pro Arg Pro Val Leu Arg Ser Val Asn Ser Arg Glu Pro 
                245                 250                 255     
Ser Gln Val Ile Phe Cys Asn Arg Ser Pro Arg Val Val Leu Pro Val 
            260                 265                 270         
Trp Leu Asn Phe Asp Gly Glu Pro Gln Pro Tyr Pro Thr Leu Pro Pro 
        275                 280                 285             
Gly Thr Gly Arg Arg Ile His Ser Tyr Arg Gly His Leu Trp Leu Phe 
    290                 295                 300                 
Arg Asp Ala Gly Thr His Asp Gly Leu Leu Val Asn Gln Thr Glu Leu 
305                 310                 315                 320 
Phe Val Pro Ser Leu Asn Val Asp Gly Gln Pro Ile Phe Ala Asn Ile 
                325                 330                 335     
Thr Leu Pro Val Tyr Thr Leu Lys Glu Arg Cys Leu Gln Val Val Arg 
            340                 345                 350         
Ser Leu Val Lys Pro Glu Asn Tyr Arg Arg Leu Asp Ile Val Arg Ser 
        355                 360                 365             
Leu Tyr Glu Asp Leu Glu Asp His Pro Asn Val Gln Lys Asp Leu Glu 
    370                 375                 380                 
Arg Leu Thr Gln Glu Arg Ile Ala His Gln Arg Met Gly Asp 
385                 390                 395             

<210> 280
<211> 151
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2B (C88A)

<400> 280
Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Leu Gln 
1               5                   10                  15      
Glu Asp Pro Pro Val Gly Val Ser Gly Ala Pro Ser Glu Asn Asn Ile 
            20                  25                  30          
Met Gln Trp Asn Ala Val Ile Phe Gly Pro Glu Gly Thr Pro Phe Glu 
        35                  40                  45              
Asp Gly Thr Phe Lys Leu Val Ile Glu Phe Ser Glu Glu Tyr Pro Asn 
    50                  55                  60                  
Lys Pro Pro Thr Val Arg Phe Leu Ser Lys Met Phe His Pro Asn Val 
65                  70                  75                  80  
Tyr Ala Asp Gly Ser Ile Ala Leu Asp Ile Leu Gln Asn Arg Trp Ser 
                85                  90                  95      
Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr Ser Ile Gln Ser Leu Leu 
            100                 105                 110         
Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn Ser Gln Ala Ala Gln Leu 
        115                 120                 125             
Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys Arg Val Ser Ala Ile Val 
    130                 135                 140                 
Glu Gln Ser Trp Asn Asp Ser 
145                 150     

<210> 281
<211> 144
<212> PRT
<213> Artificial Sequence


<220> 
<223> UBE2D1 (F62A)

<400> 281
Ala Leu Lys Arg Ile Gln Lys Glu Leu Ser Asp Leu Gln Arg Asp Pro 
1               5                   10                  15      
Pro Ala His Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His Trp 
            20                  25                  30          
Gln Ala Thr Ile Met Gly Pro Pro Asp Ser Ala Tyr Gln Gly Gly Val 
        35                  40                  45              
Phe Phe Leu Thr Val His Phe Pro Thr Asp Tyr Pro Ala Lys Pro Pro 
    50                  55                  60                  
Lys Ile Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser Asn 
65                  70                  75                  80  
Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala Leu 
                85                  90                  95      
Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp Pro 
            100                 105                 110         
Asn Pro Asp Asp Pro Leu Val Pro Asp Ile Ala Gln Ile Tyr Lys Ser 
        115                 120                 125             
Asp Lys Glu Lys Tyr Asn Arg His Ala Arg Glu Trp Thr Gln Lys Tyr 
    130                 135                 140                 



