               SEQUENCE LISTING

<110> INSERM (Institut National de la Santé et de la Recherche Médicale)
      INSTITUT JEAN PAOLI & IRENE CALMETTES
      ALDERAAN BIOTECHNOLOGY
      CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
      UNIVERSITE D’AIX-MARSEILLE
      UNIVERSITE DE PARIS
      UNIVERSITE PARIS EST CRETEIL VAL DE MARNE
      OLIVE Daniel
      BENSUSSAN Armand
      GIUSTINIANI Jérôme
      MARIE-CARDINE Anne
      FOUSSAT Arnaud
      HOUACINE Jemila

<120> ANTI-CD25 ANTIBODIES

<130> IBIO-1666/PCT

<150> EP20306421.7
<151> 2020-11-20

<160> 43

<170> BiSSAP 1.3.6

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X is N or S

<220> 
<223> CDR1 VH

<400> 1
Xaa His Ala Met Ala 
1               5   

<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VH

<220> 
<221> SITE
<222> 12
<223> X is R or A

<400> 2
Tyr Ile Ser Tyr Asp Gly Asp Asn Thr Tyr Tyr Xaa Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 3
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 VH

<400> 3
Gly Gly Asn Ser Gly Tyr Asp 
1               5           

<210> 4
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X is K or R

<220> 
<223> CDR1 VL

<220> 
<221> SITE
<222> 2
<223> X is G or A

<400> 4
Xaa Xaa Ser Gln Asn Val Asn Lys Phe Leu Asn 
1               5                   10      

<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VL

<220> 
<221> SITE
<222> 7
<223> X is T or S

<400> 5
Gly Thr Asn Ser Leu Gln Xaa 
1               5           

<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 VL

<400> 6
Gln Gln Tyr Thr Ser Trp Pro Trp Thr 
1               5                   

<210> 7
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 VH

<400> 7
Asn His Ala Met Ala 
1               5   

<210> 8
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VH

<400> 8
Tyr Ile Ser Tyr Asp Gly Asp Asn Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 9
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 VL

<400> 9
Arg Ala Ser Gln Asn Val Asn Lys Phe Leu Asn 
1               5                   10      

<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VL

<400> 10
Gly Thr Asn Ser Leu Gln Ser 
1               5           

<210> 11
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VH

<400> 11
Tyr Ile Ser Tyr Asp Gly Asp Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 12
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 VL

<400> 12
Lys Gly Ser Gln Asn Val Asn Lys Phe Leu Asn 
1               5                   10      

<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VL

<400> 13
Gly Thr Asn Ser Leu Gln Thr 
1               5           

<210> 14
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 VH

<400> 14
Ser His Ala Met Ala 
1               5   

<210> 15
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 VL

<400> 15
Arg Gly Ser Gln Asn Val Asn Lys Phe Leu Asn 
1               5                   10      

<210> 16
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 VL

<400> 16
Lys Ala Ser Gln Asn Val Asn Lys Phe Leu Asn 
1               5                   10      

<210> 17
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH

<220> 
<221> SITE
<222> 31
<223> X is N or S

<220> 
<221> SITE
<222> 42
<223> X is K or G

<220> 
<221> SITE
<222> 61
<223> X is R or A

<220> 
<221> SITE
<222> 75
<223> X is A or S

<220> 
<221> SITE
<222> 76
<223> X is Q or K

<220> 
<221> SITE
<222> 77
<223> X is S or N

<400> 17
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Xaa His 
            20                  25                  30          
Ala Met Ala Trp Val Arg Gln Ala Pro Xaa Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Tyr Asp Gly Asp Asn Thr Tyr Tyr Xaa Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Xaa Xaa Xaa Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Thr Gly Gly Asn Ser Gly Tyr Asp Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 18
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL

<220> 
<221> SITE
<222> 24
<223> X is K or R

<220> 
<221> SITE
<222> 25
<223> X is G or A

<220> 
<221> SITE
<222> 40
<223> X is L or P

<220> 
<221> SITE
<222> 42
<223> X is E or K

<220> 
<221> SITE
<222> 56
<223> X is T or S

<220> 
<221> SITE
<222> 71
<223> X is Y or F

<400> 18
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Xaa Xaa Ser Gln Asn Val Asn Lys Phe 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Xaa Gly Xaa Ala Pro Arg Arg Leu Ile 
        35                  40                  45              
Tyr Gly Thr Asn Ser Leu Gln Xaa Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Xaa Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Thr Ser Trp Pro Trp 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 19
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH

<400> 19
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn His 
            20                  25                  30          
Ala Met Ala Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Tyr Asp Gly Asp Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Ser Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Thr Gly Gly Asn Ser Gly Tyr Asp Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 20
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH

<400> 20
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn His 
            20                  25                  30          
Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Tyr Asp Gly Asp Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Thr Gly Gly Asn Ser Gly Tyr Asp Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 21
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH

<400> 21
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn His 
            20                  25                  30          
Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Tyr Asp Gly Asp Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Thr Gly Gly Asn Ser Gly Tyr Asp Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 22
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH

<400> 22
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          
Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Tyr Asp Gly Asp Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Thr Gly Gly Asn Ser Gly Tyr Asp Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 23
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH

<400> 23
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          
Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Tyr Asp Gly Asp Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Thr Gly Gly Asn Ser Gly Tyr Asp Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 24
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL

<400> 24
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Gly Ser Gln Asn Val Asn Lys Phe 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Arg Arg Leu Ile 
        35                  40                  45              
Tyr Gly Thr Asn Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Thr Ser Trp Pro Trp 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 25
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL

<400> 25
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asn Lys Phe 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              
Tyr Gly Thr Asn Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Thr Ser Trp Pro Trp 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 26
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL

<400> 26
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asn Lys Phe 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              
Tyr Gly Thr Asn Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Thr Ser Trp Pro Trp 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 27
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> Leader sequence

<400> 27
Met Asp Ile Arg Leu Ser Leu Ala Phe Leu Val Leu Phe Ile Lys Gly 
1               5                   10                  15      
Val Gln Cys 
            

<210> 28
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> Leader sequence

<400> 28
Met Ala Ala Val Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro Ala 
1               5                   10                  15      
Met Arg Cys 
            

<210> 29
<211> 348
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH

<400> 29
caagtgcagc tggtcgaatc cggaggcgga gtggtccagc ccggcagatc tctgagactg      60

agctgtgctg cctccggctt cacattcagc aaccacgcta tggcttgggt gagacaagcc     120

cctaagaagg gactggaatg ggtggcctac atcagctacg acggcgacaa cacatactat     180

agggacagcg tcaagggaag gttcactatc tctagggaca atgcccagag cactctgtat     240

ctgcagatga attctctgag ggccgaggat acagccgtct actactgcac aactggcggc     300

aatagcggct acgattgggg ccaaggcact ctggtgacag tgagcagc                  348


<210> 30
<211> 348
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH

<400> 30
caagtgcagc tggtggaaag cggaggaggc gtcgtgcagc ccggaaggtc tctgagactg      60

agctgtgccg ccagcggctt cacattcagc aaccacgcca tggcttgggt gagacaagcc     120

cccggcaaag gactggagtg ggtggcctac atctcctacg acggcgacaa cacttactat     180

agggacagcg tcaagggcag attcacaatc tctagggaca acgccaagag cactctgtat     240

ctgcagatga actctctgag ggctgaggat acagccgtgt actactgcac tactggcggc     300

aacagcggct atgattgggg ccaaggcact ctggtcactg tgagcagc                  348


<210> 31
<211> 348
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH

<400> 31
caagtgcagc tggtggaatc cggaggcggc gtggtgcaac ccggcagatc tctgagactg      60

agctgtgccg ccagcggctt cactttcagc aatcacgcca tggcttgggt gagacaagcc     120

cccggcaagg gactggagtg ggtcgcctac atctcctacg acggcgacaa cacatactac     180

gccgacagcg tcaagggaag gttcactatc tctagggaca atgccaagag cacactgtat     240

ctgcagatga actctctgag ggccgaggac actgccgtgt actactgcac aactggcggc     300

aatagcggct acgattgggg ccaaggcact ctggtgacag tgagcagc                  348


<210> 32
<211> 348
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH

<400> 32
caagtgcagc tggtggagag cggcggagga gtggtgcaac ccggaaggtc tctgagactg      60

agctgtgccg ccagcggctt tactttcagc agccacgcta tggcttgggt gaggcaagcc     120

cccggcaagg gactggagtg ggtcgcctac atctcctacg acggcgacaa cacatactac     180

gccgacagcg tcaagggaag gttcacaatc tctagggaca acagcaagag cactctgtat     240

ctgcagatga actctctgag agccgaggac acagccgtct actactgcac aactggcggc     300

aatagcggct acgattgggg ccaaggcact ctggtgacag tgagcagc                  348


<210> 33
<211> 348
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH

<400> 33
caagtgcagc tggtggaaag cggaggcggc gtggtgcaac ccggcagatc tctgagactg      60

agctgtgccg ccagcggctt cacattcagc tcccacgcca tggcttgggt gagacaagcc     120

cccggcaaag gactggagtg ggtcgcctac atctcctacg acggcgacaa cacatactac     180

gccgatagcg tgaagggaag gttcactatc tctagggaca acagcaagaa cactctgtat     240

ctgcagatga actctctgag ggctgaggat acagccgtct actactgcac aactggcggc     300

aatagcggct atgattgggg ccaaggcact ctggtgacag tgagcagc                  348


<210> 34
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL

<400> 34
gatattcaga tgacacagag ccctagctct ctgagcgcta gcgtgggaga tagggtgaca      60

atcacatgca agggcagcca gaacgtgaac aagtttctga actggtatca gcagaagctg     120

ggcgaggccc ctaggaggct gatctacggc acaaactctc tgcagactgg cgtcccaagc     180

agatttagcg gcagcggaag cggcactgac tacacactga caatcagctc tctgcagcca     240

gaggacttcg ccacatacta ctgccagcag tacacaagct ggccttggac tttcggccaa     300

ggcactaagc tggagatcaa g                                               321


<210> 35
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL

<400> 35
gatatccaga tgactcagag cccttcctct ctgagcgcta gcgtgggaga tagggtgact      60

atcacatgta gggccagcca gaacgtcaac aagtttctga actggtatca gcagaagccc     120

ggcaaggccc caaggaggct gatctacggc actaactctc tgcagagcgg cgtgccaagc     180

agatttagcg gcagcggaag cggcactgac tacacactga ctatcagctc tctgcagcca     240

gaggacttcg ccacatacta ctgccagcag tacactagct ggccttggac attcggccaa     300

ggcacaaagc tggagatcaa a                                               321


<210> 36
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL

<400> 36
gacatccaga tgacacagag ccctagctct ctgagcgcta gcgtgggaga tagggtgaca      60

atcacatgta gggccagcca gaacgtgaac aagtttctga actggtatca gcagaagccc     120

ggcaaggccc ctaggaggct gatctacggc acaaattctc tgcagagcgg cgtgcctagc     180

agatttagcg gcagcggaag cggcactgac ttcacactga ctatcagctc tctgcagcca     240

gaggacttcg ccacatacta ctgccagcag tacacaagct ggccttggac attcggccaa     300

ggcacaaagc tggagatcaa g                                               321


<210> 37
<211> 57
<212> DNA
<213> Artificial Sequence


<220> 
<223> Leader sequence

<400> 37
atggacatca ggctcagctt ggctttcctt gtccttttca taaaaggtgt ccagtgt        57


<210> 38
<211> 57
<212> DNA
<213> Artificial Sequence


<220> 
<223> Leader sequence

<400> 38
atggctgcag ttcaactctt agggctgctg ctgctttggc tcccagccat gagatgt        57


<210> 39
<211> 272
<212> PRT
<213> Homo sapiens


<400> 39
Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      
Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          
His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              
Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  
Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  
Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      
Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         
Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
        115                 120                 125             
Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
    130                 135                 140                 
Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
145                 150                 155                 160 
Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
                165                 170                 175     
Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
            180                 185                 190         
Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
        195                 200                 205             
Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
    210                 215                 220                 
Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
225                 230                 235                 240 
Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
                245                 250                 255     
Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
            260                 265                 270         



<210> 40
<211> 153
<212> PRT
<213> Homo sapiens


<400> 40
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          
Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 
Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             

<210> 41
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH

<220> 
<221> SITE
<222> 42
<223> X is K or G

<220> 
<221> SITE
<222> 76
<223> X is Q or K

<400> 41
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn His 
            20                  25                  30          
Ala Met Ala Trp Val Arg Gln Ala Pro Xaa Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Tyr Asp Gly Asp Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Xaa Ser Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Thr Gly Gly Asn Ser Gly Tyr Asp Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 42
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL

<220> 
<221> SITE
<222> 71
<223> X is Y or F

<400> 42
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asn Lys Phe 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Arg Leu Ile 
        35                  40                  45              
Tyr Gly Thr Asn Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Xaa Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Thr Ser Trp Pro Trp 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 43
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH

<220> 
<221> SITE
<222> 77
<223> X is S or N

<400> 43
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          
Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Tyr Asp Gly Asp Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Xaa Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Thr Gly Gly Asn Ser Gly Tyr Asp Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

