               SEQUENCE LISTING

<110> UNIVERSITE DE PARIS
      INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
      CLINISCIENCES
      INSTITUT CURIE

<120> METHODS AND KITS FOR CLASSIFYING SUBJECTS AFFLICTED BY SOLID CANCER

<130> 0825-IDF50-EP-PC

<160> 27

<170> BiSSAP 1.3.6

<210> 1
<211> 579
<212> PRT
<213> Homo Sapiens


<400> 1
Met Leu Arg Ser Gly Pro Ala Ser Gly Pro Ser Val Pro Thr Gly Arg 
1               5                   10                  15      
Ala Met Pro Ser Arg Arg Val Ala Arg Pro Pro Ala Ala Pro Glu Leu 
            20                  25                  30          
Gly Ala Leu Gly Ser Pro Asp Leu Ser Ser Leu Ser Leu Ala Val Ser 
        35                  40                  45              
Arg Ser Thr Asp Glu Leu Glu Ile Ile Asp Glu Tyr Ile Lys Glu Asn 
    50                  55                  60                  
Gly Phe Gly Leu Asp Gly Gly Gln Pro Gly Pro Gly Glu Gly Leu Pro 
65                  70                  75                  80  
Arg Leu Val Ser Arg Gly Ala Ala Ser Leu Ser Thr Val Thr Leu Gly 
                85                  90                  95      
Pro Val Ala Pro Pro Ala Thr Pro Pro Pro Trp Gly Cys Pro Leu Gly 
            100                 105                 110         
Arg Leu Val Ser Pro Ala Pro Gly Pro Gly Pro Gln Pro His Leu Val 
        115                 120                 125             
Ile Thr Glu Gln Pro Lys Gln Arg Gly Met Arg Phe Arg Tyr Glu Cys 
    130                 135                 140                 
Glu Gly Arg Ser Ala Gly Ser Ile Leu Gly Glu Ser Ser Thr Glu Ala 
145                 150                 155                 160 
Ser Lys Thr Leu Pro Ala Ile Glu Leu Arg Asp Cys Gly Gly Leu Arg 
                165                 170                 175     
Glu Val Glu Val Thr Ala Cys Leu Val Trp Lys Asp Trp Pro His Arg 
            180                 185                 190         
Val His Pro His Ser Leu Val Gly Lys Asp Cys Thr Asp Gly Ile Cys 
        195                 200                 205             
Arg Val Arg Leu Arg Pro His Val Ser Pro Arg His Ser Phe Asn Asn 
    210                 215                 220                 
Leu Gly Ile Gln Cys Val Arg Lys Lys Glu Ile Glu Ala Ala Ile Glu 
225                 230                 235                 240 
Arg Lys Ile Gln Leu Gly Ile Asp Pro Tyr Asn Ala Gly Ser Leu Lys 
                245                 250                 255     
Asn His Gln Glu Val Asp Met Asn Val Val Arg Ile Cys Phe Gln Ala 
            260                 265                 270         
Ser Tyr Arg Asp Gln Gln Gly Gln Met Arg Arg Met Asp Pro Val Leu 
        275                 280                 285             
Ser Glu Pro Val Tyr Asp Lys Lys Ser Thr Asn Thr Ser Glu Leu Arg 
    290                 295                 300                 
Ile Cys Arg Ile Asn Lys Glu Ser Gly Pro Cys Thr Gly Gly Glu Glu 
305                 310                 315                 320 
Leu Tyr Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile Ser Val Val 
                325                 330                 335     
Phe Ser Arg Ala Ser Trp Glu Gly Arg Ala Asp Phe Ser Gln Ala Asp 
            340                 345                 350         
Val His Arg Gln Ile Ala Ile Val Phe Lys Thr Pro Pro Tyr Glu Asp 
        355                 360                 365             
Leu Glu Ile Val Glu Pro Val Thr Val Asn Val Phe Leu Gln Arg Leu 
    370                 375                 380                 
Thr Asp Gly Val Cys Ser Glu Pro Leu Pro Phe Thr Tyr Leu Pro Arg 
385                 390                 395                 400 
Asp His Asp Ser Tyr Gly Val Asp Lys Lys Arg Lys Arg Gly Met Pro 
                405                 410                 415     
Asp Val Leu Gly Glu Leu Asn Ser Ser Asp Pro His Gly Ile Glu Ser 
            420                 425                 430         
Lys Arg Arg Lys Lys Lys Pro Ala Ile Leu Asp His Phe Leu Pro Asn 
        435                 440                 445             
His Gly Ser Gly Pro Phe Leu Pro Pro Ser Ala Leu Leu Pro Asp Pro 
    450                 455                 460                 
Asp Phe Phe Ser Gly Thr Val Ser Leu Pro Gly Leu Glu Pro Pro Gly 
465                 470                 475                 480 
Gly Pro Asp Leu Leu Asp Asp Gly Phe Ala Tyr Asp Pro Thr Ala Pro 
                485                 490                 495     
Thr Leu Phe Thr Met Leu Asp Leu Leu Pro Pro Ala Pro Pro His Ala 
            500                 505                 510         
Ser Ala Val Val Cys Ser Gly Gly Ala Gly Ala Val Val Gly Glu Thr 
        515                 520                 525             
Pro Gly Pro Glu Pro Leu Thr Leu Asp Ser Tyr Gln Ala Pro Gly Pro 
    530                 535                 540                 
Gly Asp Gly Gly Thr Ala Ser Leu Val Gly Ser Asn Met Phe Pro Asn 
545                 550                 555                 560 
His Tyr Arg Glu Ala Ala Phe Gly Gly Gly Leu Leu Ser Pro Gly Pro 
                565                 570                 575     
Glu Ala Thr 
            

<210> 2
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> pSer 472 RelB immunogenic peptide

<220> 
<221> MOD_RES
<222> 4
<223> PHOSPHORYLATION

<400> 2
Gly Thr Val Ser Leu Pro Gly Leu Glu Pro Pro Gly Gly 
1               5                   10              

<210> 3
<211> 558
<212> PRT
<213> Mus Musculus


<400> 3
Met Pro Ser Arg Arg Ala Ala Arg Glu Ser Ala Pro Glu Leu Gly Ala 
1               5                   10                  15      
Leu Gly Ser Ser Asp Leu Ser Ser Leu Ser Leu Thr Val Ser Arg Thr 
            20                  25                  30          
Thr Asp Glu Leu Glu Ile Ile Asp Glu Tyr Ile Lys Glu Asn Gly Phe 
        35                  40                  45              
Gly Leu Asp Gly Thr Gln Leu Ser Glu Met Pro Arg Leu Val Pro Arg 
    50                  55                  60                  
Gly Pro Ala Ser Leu Ser Ser Val Thr Leu Gly Pro Ala Ala Pro Pro 
65                  70                  75                  80  
Pro Pro Ala Thr Pro Ser Trp Ser Cys Thr Leu Gly Arg Leu Val Ser 
                85                  90                  95      
Pro Gly Pro Cys Pro Arg Pro Tyr Leu Val Ile Thr Glu Gln Pro Lys 
            100                 105                 110         
Gln Arg Gly Met Arg Phe Arg Tyr Glu Cys Glu Gly Arg Ser Ala Gly 
        115                 120                 125             
Ser Ile Leu Gly Glu Ser Ser Thr Glu Ala Ser Lys Thr Leu Pro Ala 
    130                 135                 140                 
Ile Glu Leu Arg Asp Cys Gly Gly Leu Arg Glu Val Glu Val Thr Ala 
145                 150                 155                 160 
Cys Leu Val Trp Lys Asp Trp Pro His Arg Val His Pro His Ser Leu 
                165                 170                 175     
Val Gly Lys Asp Cys Thr Asp Gly Val Cys Arg Val Arg Leu Arg Pro 
            180                 185                 190         
His Val Ser Pro Arg His Ser Phe Asn Asn Leu Gly Ile Gln Cys Val 
        195                 200                 205             
Arg Lys Lys Glu Ile Glu Ala Ala Ile Glu Arg Lys Ile Gln Leu Gly 
    210                 215                 220                 
Ile Asp Pro Tyr Asn Ala Gly Ser Leu Lys Asn His Gln Glu Val Asp 
225                 230                 235                 240 
Met Asn Val Val Arg Ile Cys Phe Gln Ala Ser Tyr Arg Asp Gln Gln 
                245                 250                 255     
Gly His Leu His Arg Met Asp Pro Ile Leu Ser Glu Pro Val Tyr Asp 
            260                 265                 270         
Lys Lys Ser Thr Asn Thr Ser Glu Leu Arg Ile Cys Arg Ile Asn Lys 
        275                 280                 285             
Glu Ser Gly Pro Cys Thr Gly Gly Glu Glu Leu Tyr Leu Leu Cys Asp 
    290                 295                 300                 
Lys Val Gln Lys Glu Asp Ile Ser Val Val Phe Ser Thr Ala Ser Trp 
305                 310                 315                 320 
Glu Gly Arg Ala Asp Phe Ser Gln Ala Asp Val His Arg Gln Ile Ala 
                325                 330                 335     
Ile Val Phe Lys Thr Pro Pro Tyr Glu Asp Leu Glu Ile Ser Glu Pro 
            340                 345                 350         
Val Thr Val Asn Val Phe Leu Gln Arg Leu Thr Asp Gly Val Cys Ser 
        355                 360                 365             
Glu Pro Leu Pro Phe Thr Tyr Leu Pro Arg Asp His Asp Ser Tyr Gly 
    370                 375                 380                 
Val Asp Lys Lys Arg Lys Arg Gly Leu Pro Asp Val Leu Gly Glu Leu 
385                 390                 395                 400 
Ser Ser Ser Asp Pro His Gly Ile Glu Ser Lys Arg Arg Lys Lys Lys 
                405                 410                 415     
Pro Val Phe Leu Asp His Phe Leu Pro Gly His Ser Ser Gly Leu Phe 
            420                 425                 430         
Leu Pro Pro Ser Ala Leu Gln Pro Ala Asp Ser Asp Phe Phe Pro Ala 
        435                 440                 445             
Ser Ile Ser Leu Pro Gly Leu Glu Pro Pro Gly Gly Pro Asp Leu Leu 
    450                 455                 460                 
Asp Asp Gly Phe Ala Tyr Asp Pro Ser Ala Pro Thr Leu Phe Thr Met 
465                 470                 475                 480 
Leu Asp Leu Leu Pro Pro Ala Pro Pro Leu Ala Ser Ala Val Val Gly 
                485                 490                 495     
Ser Gly Gly Ala Gly Ala Thr Val Val Glu Ser Ser Gly Pro Glu Pro 
            500                 505                 510         
Leu Ser Leu Asp Ser Phe Ala Ala Pro Gly Pro Gly Asp Val Gly Thr 
        515                 520                 525             
Ala Ser Leu Val Gly Ser Asn Met Phe Pro Asn Gln Tyr Arg Glu Ala 
    530                 535                 540                 
Ala Phe Gly Gly Gly Leu Leu Ser Pro Gly Pro Glu Ala Thr 
545                 550                 555             

<210> 4
<211> 607
<212> PRT
<213> Rattus Norvegicus


<400> 4
Met Met Pro Arg Ala Pro Cys Val Gln Pro Gly Leu Arg Pro Tyr Pro 
1               5                   10                  15      
Cys Ala Ala Ser Pro Ala Gly Asp Arg Pro Asn Arg Leu Gly Cys Pro 
            20                  25                  30          
Ala Ala Arg Leu Ala Leu Val Arg Ala Arg Pro Glu Leu Ala Phe Gly 
        35                  40                  45              
Leu Ser Val Pro Thr Gly Arg Ala Met Pro Ser Arg Arg Ala Ala Arg 
    50                  55                  60                  
Glu Ser Ala Pro Glu Leu Gly Ala Leu Gly Ser Ser Asp Ile Pro Ser 
65                  70                  75                  80  
Leu Ser Arg Thr Thr Glu Ile Ile Asp Glu Tyr Ile Lys Glu Asn Gly 
                85                  90                  95      
Phe Gly Leu Asp Gly Ala Gln Leu Ser Glu Met Pro Arg Leu Val Pro 
            100                 105                 110         
Arg Gly Pro Ala Ser Leu Ser Ser Val Thr Leu Gly Pro Ala Ala Pro 
        115                 120                 125             
Pro Pro Pro Ala Thr Pro Pro Trp Asn Cys Thr Leu Gly Arg Leu Val 
    130                 135                 140                 
Ser Pro Gly Pro Cys Pro Arg Pro Tyr Leu Val Ile Thr Glu Gln Pro 
145                 150                 155                 160 
Lys Gln Arg Gly Met Arg Phe Arg Tyr Glu Cys Glu Gly Arg Ser Ala 
                165                 170                 175     
Gly Ser Ile Leu Gly Glu Ser Ser Thr Glu Ala Ser Lys Thr Leu Pro 
            180                 185                 190         
Ala Ile Glu Leu Arg Asp Cys Gly Gly Leu Arg Glu Val Glu Val Thr 
        195                 200                 205             
Ala Cys Leu Val Trp Lys Asp Trp Pro His Arg Val His Pro His Ser 
    210                 215                 220                 
Leu Val Gly Lys Asp Cys Thr Asp Gly Val Cys Arg Val Arg Leu Arg 
225                 230                 235                 240 
Pro His Val Ser Pro Arg His Ser Phe Asn Asn Leu Gly Ile Gln Cys 
                245                 250                 255     
Val Arg Lys Lys Glu Ile Glu Ala Ala Ile Glu Arg Lys Ile Gln Leu 
            260                 265                 270         
Gly Ile Asp Pro Tyr Asn Ala Gly Ser Leu Lys Asn His Gln Glu Val 
        275                 280                 285             
Asp Met Asn Val Val Arg Ile Cys Phe Gln Ala Ser Tyr Arg Asp Gln 
    290                 295                 300                 
Gln Gly His Leu His Arg Met Asp Pro Ile Leu Ser Glu Pro Val Tyr 
305                 310                 315                 320 
Asp Lys Lys Ser Thr Asn Thr Ser Glu Leu Arg Ile Cys Arg Ile Asn 
                325                 330                 335     
Lys Glu Ser Gly Pro Cys Thr Gly Gly Glu Glu Leu Tyr Leu Leu Cys 
            340                 345                 350         
Asp Lys Val Gln Lys Glu Asp Ile Ser Val Val Phe Ser Thr Ala Ser 
        355                 360                 365             
Trp Glu Gly Arg Ala Asp Phe Ser Gln Ala Asp Val His Arg Gln Ile 
    370                 375                 380                 
Ala Ile Val Phe Lys Thr Pro Pro Tyr Glu Asp Leu Glu Ile Ser Glu 
385                 390                 395                 400 
Pro Val Thr Val Asn Val Phe Leu Gln Arg Leu Thr Asp Gly Val Cys 
                405                 410                 415     
Ser Glu Pro Leu Pro Phe Thr Tyr Leu Pro Arg Asp His Asp Ser Tyr 
            420                 425                 430         
Gly Val Asp Lys Lys Arg Lys Arg Gly Leu Pro Asp Val Leu Gly Glu 
        435                 440                 445             
Leu Ser Ser Ser Asp Pro His Gly Ile Glu Ser Lys Arg Arg Lys Lys 
    450                 455                 460                 
Lys Pro Val Phe Leu Asp His Phe Leu Pro Gly His Ser Ser Gly Leu 
465                 470                 475                 480 
Phe Leu Pro Pro Ser Ala Leu Gln Ser Ala Asp Thr Asp Phe Phe Pro 
                485                 490                 495     
Gly Thr Ile Ser Leu Pro Gly Leu Glu Pro Pro Gly Gly Pro Asp Leu 
            500                 505                 510         
Leu Asp Asp Gly Phe Ala Tyr Asp Pro Ser Ala Pro Thr Leu Phe Thr 
        515                 520                 525             
Met Leu Asp Leu Leu Pro Pro Ala Pro Pro Leu Ala Ser Ala Val Val 
    530                 535                 540                 
Gly Asn Gly Gly Ala Gly Ala Thr Val Val Glu Ser Pro Gly Pro Glu 
545                 550                 555                 560 
Pro Leu Ser Leu Asp Ser Phe Ala Ala Pro Gly Pro Gly Asp Val Gly 
                565                 570                 575     
Thr Ala Ser Leu Val Gly Ser Asn Met Phe Pro Asn Gln Tyr Arg Glu 
            580                 585                 590         
Ala Ala Phe Gly Gly Gly Leu Leu Ser Pro Gly Pro Glu Ala Thr 
        595                 600                 605         

<210> 5
<211> 560
<212> PRT
<213> Canis lupus familiaris


<400> 5
Met Pro Ser Arg Arg Val Ala Arg Pro Ser Ala Ala Pro Glu Leu Gly 
1               5                   10                  15      
Ala Leu Gly Ser Thr Asp Leu Ser Ser Leu Ala Val Ser Arg Thr Thr 
            20                  25                  30          
Glu Ile Ile Asp Glu Tyr Ile Lys Glu Asn Gly Phe Gly Leu Glu Gly 
        35                  40                  45              
Ala Gln Leu Gly Pro Gly Glu Gly Leu Pro Arg Leu Val Ser Arg Gly 
    50                  55                  60                  
Ala Ala Ser Leu Ser Thr Val Thr Leu Gly Pro Pro Ala Pro Pro Pro 
65                  70                  75                  80  
Pro Ala Thr Pro Pro Pro Trp Gly Cys His Leu Gly Arg Val Met Pro 
                85                  90                  95      
Gln Ala Pro Gly Pro Gly Pro Arg Pro His Leu Val Ile Thr Glu Gln 
            100                 105                 110         
Pro Lys Gln Arg Gly Met Arg Phe Arg Tyr Glu Cys Glu Gly Arg Ser 
        115                 120                 125             
Ala Gly Ser Ile Leu Gly Glu Ser Ser Thr Glu Ala Ser Lys Thr Leu 
    130                 135                 140                 
Pro Ala Ile Glu Leu Arg Asp Cys Gly Gly Leu Arg Glu Val Glu Val 
145                 150                 155                 160 
Thr Ala Cys Leu Val Trp Lys Asp Trp Pro His Arg Val His Pro His 
                165                 170                 175     
Ser Leu Val Gly Lys Asp Cys Thr Asp Gly Val Cys Arg Val Arg Leu 
            180                 185                 190         
Arg Pro His Val Ser Pro Arg His Ser Phe Asn Asn Leu Gly Ile Gln 
        195                 200                 205             
Cys Val Arg Lys Lys Glu Ile Glu Ala Ala Ile Glu Arg Lys Ile Gln 
    210                 215                 220                 
Leu Gly Ile Asp Pro Tyr Asn Ala Gly Ser Leu Lys Asn His Gln Glu 
225                 230                 235                 240 
Val Asp Met Asn Val Val Arg Ile Cys Phe Gln Ala Ser Tyr Arg Asp 
                245                 250                 255     
Gln Gln Gly Gln Met Arg Arg Met Asp Pro Val Leu Ser Glu Pro Val 
            260                 265                 270         
Tyr Asp Lys Lys Ser Thr Asn Thr Ser Glu Leu Arg Ile Cys Arg Ile 
        275                 280                 285             
Asn Lys Glu Ser Gly Pro Cys Thr Gly Gly Glu Glu Leu Tyr Leu Leu 
    290                 295                 300                 
Cys Asp Lys Val Gln Lys Glu Asp Ile Ser Val Val Phe Ser Arg Ala 
305                 310                 315                 320 
Ser Trp Glu Gly Arg Ala Asp Phe Ser Gln Ala Asp Val His Arg Gln 
                325                 330                 335     
Ile Ala Ile Val Phe Lys Thr Pro Pro Tyr Glu Asp Leu Glu Ile Val 
            340                 345                 350         
Glu Pro Val Thr Val Asn Val Phe Leu Gln Arg Leu Thr Asp Gly Val 
        355                 360                 365             
Cys Ser Glu Pro Leu Pro Phe Thr Tyr Leu Pro Arg Asp His Asp Ser 
    370                 375                 380                 
Tyr Gly Val Asp Lys Lys Arg Lys Arg Gly Met Pro Asp Val Leu Gly 
385                 390                 395                 400 
Glu Leu Asn Ser Ser Asp Pro His Gly Ile Glu Ser Lys Arg Arg Arg 
                405                 410                 415     
Lys Lys Pro Ala Phe Leu Asp His Phe Leu Pro Asn Ser Ser Ser Gly 
            420                 425                 430         
Pro Phe Leu Pro Pro Ser Ala Leu Leu Pro Asp Thr Asp Phe Phe Pro 
        435                 440                 445             
Gly Thr Val Ser Leu Pro Gly Leu Glu Pro Pro Gly Gly Pro Asp Leu 
    450                 455                 460                 
Leu Asp Asp Ser Phe Ala Tyr Asp Asp Ser Thr Ala Pro Thr Leu Phe 
465                 470                 475                 480 
Thr Met Leu Asp Met Leu Pro Pro Ala Pro Pro Leu Ala Ser Ala Val 
                485                 490                 495     
Thr Gly Asn Gly Ala Ala Gly Pro Ala Val Gly Glu Pro Ser Gly Pro 
            500                 505                 510         
Glu Pro Met Thr Leu Asp Ser Tyr Gln Ala Pro Gly Pro Gly Asp Gly 
        515                 520                 525             
Gly Thr Ala Ser Leu Val Gly Ser Asn Met Phe Pro Asn Gln Tyr Arg 
    530                 535                 540                 
Glu Val Gly Phe Gly Gly Gly Leu Leu Ser Pro Gly Pro Glu Ala Thr 
545                 550                 555                 560 



<210> 6
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-CDR1 of anti pSer 472 RelB monoclonal antibody

<400> 6
Arg Ala Ser Lys Ser Val Tyr Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  

<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-CDR2 of anti pSer 472 RelB monoclonal antibody

<400> 7
Tyr Ala Ser Asn Leu Gln Ser 
1               5           

<210> 8
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-CDR3 of anti pSer 472 RelB monoclonal antibody

<400> 8
Gln His Asn Trp Glu Ile Pro Leu Thr 
1               5                   

<210> 9
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> H-CDR1 of anti pSer 472 RelB monoclonal antibody

<400> 9
Thr Asp Ala Met Asn 
1               5   

<210> 10
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> H-CDR2 of anti pSer 472 RelB monoclonal antibody

<400> 10
Arg Met Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 11
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> H-CDR3 of anti pSer 472 RelB monoclonal antibody

<400> 11
Val Tyr Gly Gly Ala Met Asp Tyr 
1               5               

<210> 12
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH of anti pSer 472 RelB monoclonal antibody

<400> 12
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Asn Thr Asp 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Met Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Cys Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  
Phe Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Tyr Cys Val Tyr Gly Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 13
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL of anti pSer 472 RelB monoclonal antibody

<400> 13
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Val Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Tyr Thr Ser 
            20                  25                  30          
Gly Tyr Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Gln Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Asn Trp 
                85                  90                  95      
Glu Ile Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     

<210> 14
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA sequence of VL of anti pSer472 RelB monoclonal antibody

<400> 14
gacattgtgc tgacacagtc tcctgcttcc ttagttgtat ctctgggaca gagggccacc      60

atctcatgca gggccagcaa aagtgtctat acatctggct atagttatat gcactggttc     120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcctccaa cctacaatct     180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat     240

cctgtggagg cggaggatac tgcaacatat tactgtcagc acaattggga gattccgctc     300

acgttcggtg ctgggaccaa gctggagctg aaa                                  333


<210> 15
<211> 351
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA sequence of VH of anti pSer472 RelB monoclonal antibody

<400> 15
gaggtgcagc ttgttgagac tggtggagga ttggtgcagc ctaaagggtc attgaaactc      60

tcatgtgcag tctctggatt caccttcaat accgatgcca tgaactgggt ccgccaggct     120

ccaggaaagg gtttggaatg ggttgctcgc atgagaagta aaagtaataa ttatgcaaca     180

tattatgccg attcagtgaa agacaggtgc accatctcca gagatgattc acaaagcatg     240

ttctatctgc aaatgaacaa cttgaaaact gaggacacag ccatgtatta ctgtgtttac     300

ggaggtgcta tggactactg gggtcaagga acctcagtca ccgtctcctc a              351


<210> 16
<211> 563
<212> PRT
<213> Aotus nancymaae


<220> 
<223> uniprot KB A0A2K5CNM0

<400> 16
Met Leu Arg Ser Gly Arg Ala Ser Gly Pro Ser Val Pro Thr Gly Arg 
1               5                   10                  15      
Ala Met Pro Ser Arg Arg Val Ala Arg Pro Pro Ala Ala Ser Glu Leu 
            20                  25                  30          
Gly Ala Leu Gly Ser Pro Asp Leu Ser Ser Leu Ser Leu Ala Val Ser 
        35                  40                  45              
Arg Thr Thr Gly Glu His Pro Pro Pro Phe Leu Leu Thr His Thr Cys 
    50                  55                  60                  
Arg Met Gly Leu Gly Gly Pro Arg Gly Glu Val Ser Val Trp Gly Phe 
65                  70                  75                  80  
Thr Glu Val His Phe Ser Phe Pro Leu Thr Gly Cys Ile Pro Pro Cys 
                85                  90                  95      
Arg Leu Val Pro Pro Ala Pro Gly Pro Gly Pro Gln Pro His Leu Val 
            100                 105                 110         
Ile Thr Glu Gln Pro Lys Gln Arg Gly Met Arg Phe Arg Tyr Glu Cys 
        115                 120                 125             
Glu Gly Arg Ser Ala Gly Ser Ile Leu Gly Glu Ser Ser Thr Glu Ala 
    130                 135                 140                 
Ser Lys Thr Leu Pro Ala Ile Glu Leu Arg Asp Cys Gly Gly Leu Arg 
145                 150                 155                 160 
Glu Val Glu Val Thr Ala Cys Leu Val Trp Lys Asp Trp Pro His Arg 
                165                 170                 175     
Val His Pro His Ser Leu Val Gly Lys Asp Cys Thr Asp Gly Val Cys 
            180                 185                 190         
Arg Val Arg Leu Arg Pro His Val Ser Pro Arg His Ser Phe Asn Asn 
        195                 200                 205             
Leu Gly Ile Gln Cys Val Arg Lys Lys Glu Ile Glu Ala Ala Ile Glu 
    210                 215                 220                 
Arg Lys Ile Gln Leu Gly Ile Asp Pro Tyr Asn Ala Gly Ser Leu Lys 
225                 230                 235                 240 
Asn His Gln Glu Val Asp Met Asn Val Val Arg Ile Cys Phe Gln Ala 
                245                 250                 255     
Ser Tyr Arg Asp Gln Gln Gly Gln Met Cys Arg Met Asp Pro Val Leu 
            260                 265                 270         
Ser Glu Pro Val Tyr Asp Lys Lys Ser Thr Asn Thr Ser Glu Leu Arg 
        275                 280                 285             
Ile Cys Arg Ile Asn Lys Glu Ser Gly Pro Cys Thr Gly Gly Glu Glu 
    290                 295                 300                 
Leu Tyr Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile Ser Val Val 
305                 310                 315                 320 
Phe Ser Thr Ala Ser Trp Glu Gly Arg Ala Asp Phe Ser Gln Ala Asp 
                325                 330                 335     
Val His Arg Gln Ile Ala Ile Val Phe Lys Thr Pro Pro Tyr Glu Asp 
            340                 345                 350         
Leu Glu Ile Val Glu Pro Val Thr Val Asn Val Phe Leu Gln Arg Leu 
        355                 360                 365             
Thr Asp Gly Val Cys Ser Glu Pro Leu Pro Phe Thr Tyr Leu Pro Arg 
    370                 375                 380                 
Asp His Asp Ser Tyr Gly Val Asp Lys Lys Arg Lys Arg Gly Met Pro 
385                 390                 395                 400 
Asp Val Leu Gly Glu Leu Asn Ser Ser Asp Pro His Gly Ile Glu Ser 
                405                 410                 415     
Lys Arg Arg Lys Lys Lys Pro Ala Phe Leu Asp His Phe Leu Pro Ser 
            420                 425                 430         
His Gly Ser Gly Pro Phe Leu Pro Pro Ser Ala Leu Leu Pro Asp Pro 
        435                 440                 445             
Asp Phe Phe Ser Gly Thr Val Ser Leu Pro Gly Leu Glu Pro Pro Gly 
    450                 455                 460                 
Gly Pro Asp Leu Leu Asp Asp Gly Phe Ala Tyr Asp Pro Thr Ala Ser 
465                 470                 475                 480 
Pro Leu Leu Thr Met Leu Asp Leu Leu Pro Pro Ala Pro Pro His Ala 
                485                 490                 495     
Ser Ala Val Val Cys Ser Gly Gly Ala Gly Ala Val Val Gly Glu Pro 
            500                 505                 510         
Pro Gly Pro Glu Pro Leu Thr Leu Asp Ser Tyr Gln Gly Pro Gly Pro 
        515                 520                 525             
Gly Asp Gly Gly Thr Ala Ser Leu Val Gly Ser Asn Met Phe Pro Asn 
    530                 535                 540                 
Gln Tyr Arg Glu Ala Ala Phe Gly Gly Gly Leu Leu Ser Pro Gly Pro 
545                 550                 555                 560 
Glu Ala Thr 
            

<210> 17
<211> 541
<212> PRT
<213> Rhinopithecus bieti


<220> 
<223> uniproKB A0A2K6M5W6

<400> 17
Ser Pro Asp Leu Ser Ser Leu Ser Leu Thr Val Ser Arg Ser Thr Asp 
1               5                   10                  15      
Glu Leu Glu Ile Ile Asp Glu Tyr Ile Lys Glu Asn Gly Phe Gly Leu 
            20                  25                  30          
Asp Gly Gly Gln Ser Gly Pro Gly Glu Gly Leu Pro Arg Leu Val Ser 
        35                  40                  45              
Arg Gly Ala Ala Ser Leu Ser Thr Val Thr Leu Gly Pro Val Ala Pro 
    50                  55                  60                  
Pro Ala Thr Pro Pro Pro Trp Gly Cys Pro Leu Gly Arg Leu Val Pro 
65                  70                  75                  80  
Pro Thr Gln Gly Pro Gly Leu Gln Pro His Leu Val Ile Thr Glu Gln 
                85                  90                  95      
Pro Lys Gln Arg Gly Met Arg Phe Arg Tyr Glu Cys Glu Gly Arg Ser 
            100                 105                 110         
Ala Gly Ser Ile Leu Gly Glu Ser Ser Thr Glu Ala Ser Lys Thr Leu 
        115                 120                 125             
Pro Ala Ile Glu Leu Arg Asp Cys Gly Gly Leu Arg Glu Val Glu Val 
    130                 135                 140                 
Thr Ala Cys Leu Val Trp Lys Asp Trp Pro His Arg Val His Pro His 
145                 150                 155                 160 
Ser Leu Val Gly Lys Asp Cys Thr Asp Gly Val Cys Arg Val Arg Leu 
                165                 170                 175     
Arg Pro His Val Ser Pro Arg His Ser Phe Asn Asn Leu Gly Ile Gln 
            180                 185                 190         
Cys Val Arg Lys Lys Glu Ile Glu Ala Ala Ile Glu Arg Lys Ile Gln 
        195                 200                 205             
Leu Gly Ile Asp Pro Tyr Asn Ala Gly Ser Leu Lys Asn His Gln Glu 
    210                 215                 220                 
Val Asp Met Asn Val Val Arg Ile Cys Phe Gln Ala Ser Tyr Arg Asp 
225                 230                 235                 240 
Gln Gln Gly Gln Met Arg Arg Met Asp Pro Val Leu Ser Glu Pro Val 
                245                 250                 255     
Tyr Asp Lys Lys Ser Thr Asn Thr Ser Glu Leu Arg Ile Cys Arg Ile 
            260                 265                 270         
Asn Lys Glu Ser Gly Pro Cys Thr Gly Gly Glu Glu Leu Tyr Leu Leu 
        275                 280                 285             
Cys Asp Lys Val Gln Lys Glu Asp Ile Ser Val Val Phe Ser Arg Ala 
    290                 295                 300                 
Ser Trp Glu Gly Arg Ala Asp Phe Ser Gln Ala Asp Val His Arg Gln 
305                 310                 315                 320 
Ile Ala Ile Val Phe Lys Thr Pro Pro Tyr Glu Asp Leu Glu Ile Val 
                325                 330                 335     
Glu Pro Val Thr Val Asn Val Phe Leu Gln Arg Leu Thr Asp Gly Val 
            340                 345                 350         
Cys Ser Glu Pro Leu Pro Phe Thr Tyr Leu Pro Arg Asp His Asp Ser 
        355                 360                 365             
Tyr Gly Val Asp Lys Lys Arg Lys Arg Gly Met Pro Asp Val Leu Gly 
    370                 375                 380                 
Glu Leu Asn Ser Ser Asp Pro His Gly Ile Glu Ser Lys Arg Arg Lys 
385                 390                 395                 400 
Lys Lys Pro Ala Ile Leu Asp His Phe Leu Pro Ser His Gly Ser Gly 
                405                 410                 415     
Pro Phe Leu Pro Pro Ser Ala Leu Leu Pro Asp Pro Asp Phe Phe Ser 
            420                 425                 430         
Gly Thr Val Ser Leu Pro Gly Leu Glu Pro Pro Gly Gly Pro Asp Leu 
        435                 440                 445             
Leu Asp Asp Gly Phe Ala Tyr Asp Pro Thr Ala Pro Thr Leu Phe Thr 
    450                 455                 460                 
Met Leu Asp Leu Leu Pro Pro Ala Pro Pro His Ala Ser Ala Val Val 
465                 470                 475                 480 
Cys Ser Ala Gly Ala Val Val Gly Glu Pro Pro Gly Pro Glu Pro Leu 
                485                 490                 495     
Thr Leu Asp Ser Tyr Gln Ala Pro Gly Pro Gly Asp Gly Gly Thr Ala 
            500                 505                 510         
Ser Leu Val Gly Ser Asn Met Phe Pro Asn Gln Tyr Arg Glu Ala Ala 
        515                 520                 525             
Phe Gly Gly Gly Leu Leu Ser Pro Gly Pro Glu Ala Thr 
    530                 535                 540     

<210> 18
<211> 579
<212> PRT
<213> Saimiri boliviensis


<220> 
<223> uniprot KB A0A2K6UKJ8

<220> 
<221> UNSURE
<222> 94..121
<223> Xaa

<400> 18
Met Leu Arg Ser Gly Arg Ala Ser Gly Pro Ser Val Pro Thr Gly Arg 
1               5                   10                  15      
Ala Met Pro Ser Arg Arg Val Ala Arg Pro Pro Ala Ala Ser Glu Leu 
            20                  25                  30          
Gly Ala Leu Gly Ser Pro Asp Leu Ser Ser Leu Ser Leu Ala Val Ser 
        35                  40                  45              
Arg Thr Thr Asp Glu Leu Glu Ile Ile Asp Glu Tyr Ile Lys Glu Asn 
    50                  55                  60                  
Gly Phe Gly Leu Asp Arg Ala Gln Pro Gly Pro Gly Glu Gly Leu Pro 
65                  70                  75                  80  
Arg Leu Val Ser Arg Gly Ala Ala Ser Leu Ser Thr Val Xaa Xaa Xaa 
                85                  90                  95      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Pro Gln Pro His Leu Val 
        115                 120                 125             
Ile Thr Glu Gln Pro Lys Gln Arg Gly Met Arg Phe Arg Tyr Glu Cys 
    130                 135                 140                 
Glu Gly Arg Ser Ala Gly Ser Ile Leu Gly Glu Ser Ser Thr Glu Ala 
145                 150                 155                 160 
Ser Lys Thr Leu Pro Ala Ile Glu Leu Arg Asp Cys Gly Gly Leu Arg 
                165                 170                 175     
Glu Val Glu Val Thr Ala Cys Leu Val Trp Lys Asp Trp Pro His Arg 
            180                 185                 190         
Val His Pro His Ser Leu Val Gly Lys Asp Cys Thr Asp Gly Val Cys 
        195                 200                 205             
Arg Val Arg Leu Arg Pro His Val Ser Pro Arg His Ser Phe Asn Asn 
    210                 215                 220                 
Leu Gly Ile Gln Cys Val Arg Lys Lys Glu Ile Glu Ala Ala Ile Glu 
225                 230                 235                 240 
Arg Lys Ile Gln Leu Gly Ile Asp Pro Tyr Asn Ala Gly Ser Leu Lys 
                245                 250                 255     
Asn His Gln Glu Val Asp Met Asn Val Val Arg Ile Cys Phe Gln Ala 
            260                 265                 270         
Ser Tyr Arg Asp Gln Gln Gly Gln Val Cys Arg Met Asp Pro Val Leu 
        275                 280                 285             
Ser Glu Pro Val Tyr Asp Lys Lys Ser Thr Asn Thr Ser Glu Leu Arg 
    290                 295                 300                 
Ile Cys Arg Ile Asn Lys Glu Ser Gly Pro Cys Thr Gly Gly Glu Glu 
305                 310                 315                 320 
Leu Tyr Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile Ser Val Val 
                325                 330                 335     
Phe Ser Thr Ala Ser Trp Glu Gly Arg Ala Asp Phe Ser Gln Ala Asp 
            340                 345                 350         
Val His Arg Gln Ile Ala Ile Val Phe Lys Thr Pro Pro Tyr Glu Asp 
        355                 360                 365             
Leu Glu Ile Val Glu Pro Val Thr Val Asn Val Phe Leu Gln Arg Leu 
    370                 375                 380                 
Thr Asp Gly Val Cys Ser Glu Pro Leu Pro Phe Thr Tyr Leu Pro Arg 
385                 390                 395                 400 
Asp His Asp Ser Tyr Gly Val Asp Lys Lys Arg Lys Arg Gly Met Pro 
                405                 410                 415     
Asp Val Leu Gly Glu Leu Asn Ser Ser Asp Pro His Gly Ile Glu Ser 
            420                 425                 430         
Lys Arg Arg Lys Lys Lys Pro Ala Phe Leu Asp His Phe Leu Pro Ser 
        435                 440                 445             
His Gly Ser Gly Pro Phe Leu Pro Pro Ser Ala Leu Leu Pro Asp Pro 
    450                 455                 460                 
Asp Phe Phe Ser Gly Thr Val Ser Leu Pro Gly Leu Glu Pro Pro Gly 
465                 470                 475                 480 
Gly Pro Asp Leu Leu Asp Asp Gly Phe Ala Tyr Asp Pro Thr Ala Thr 
                485                 490                 495     
Pro Leu Leu Thr Met Leu Asp Leu Leu Pro Pro Ala Pro Pro His Ala 
            500                 505                 510         
Ser Ala Val Val Cys Ser Gly Gly Ala Gly Ala Val Val Gly Glu Pro 
        515                 520                 525             
Pro Gly Pro Glu Pro Leu Thr Leu Asp Ser Tyr Gln Gly Pro Gly Pro 
    530                 535                 540                 
Gly Asp Gly Gly Thr Ala Ser Leu Val Gly Ser Asn Met Phe Pro Asn 
545                 550                 555                 560 
Gln Tyr Arg Glu Ala Ala Phe Gly Gly Gly Leu Leu Ser Pro Gly Pro 
                565                 570                 575     
Glu Ala Thr 
            

<210> 19
<211> 440
<212> PRT
<213> Chlorocebus sabaeus


<400> 19
Met Arg Phe Arg Tyr Glu Cys Glu Gly Arg Ser Ala Gly Ser Ile Leu 
1               5                   10                  15      
Gly Glu Ser Ser Thr Glu Ala Ser Lys Thr Leu Pro Ala Ile Glu Leu 
            20                  25                  30          
Arg Asp Cys Gly Gly Leu Arg Glu Val Glu Val Thr Ala Cys Leu Val 
        35                  40                  45              
Trp Lys Asp Trp Pro His Arg Val His Pro His Ser Leu Val Gly Lys 
    50                  55                  60                  
Asp Cys Thr Asp Gly Val Cys Arg Val Arg Leu Arg Pro His Val Ser 
65                  70                  75                  80  
Pro Arg His Ser Phe Asn Asn Leu Gly Ile Gln Cys Val Arg Lys Lys 
                85                  90                  95      
Glu Ile Glu Ala Ala Ile Glu Arg Lys Ile Gln Leu Gly Ile Asp Pro 
            100                 105                 110         
Tyr Asn Ala Gly Ser Leu Lys Asn His Gln Glu Val Asp Met Asn Val 
        115                 120                 125             
Val Arg Ile Cys Phe Gln Ala Ser Tyr Arg Asp Gln Gln Gly Gln Met 
    130                 135                 140                 
Arg Arg Met Asp Pro Val Leu Ser Glu Pro Val Tyr Asp Lys Lys Ser 
145                 150                 155                 160 
Thr Asn Thr Ser Glu Leu Arg Ile Cys Arg Ile Asn Lys Glu Ser Gly 
                165                 170                 175     
Pro Cys Thr Gly Gly Glu Glu Leu Tyr Leu Leu Cys Asp Lys Val Gln 
            180                 185                 190         
Lys Glu Asp Ile Ser Val Val Phe Ser Arg Ala Ser Trp Glu Gly Arg 
        195                 200                 205             
Ala Asp Phe Ser Gln Ala Asp Val His Arg Gln Ile Ala Ile Val Phe 
    210                 215                 220                 
Lys Thr Pro Pro Tyr Glu Asp Leu Glu Ile Val Glu Pro Val Thr Val 
225                 230                 235                 240 
Asn Val Phe Leu Gln Arg Leu Thr Asp Gly Val Cys Ser Glu Pro Leu 
                245                 250                 255     
Pro Phe Thr Tyr Leu Pro Arg Asp His Asp Ser Tyr Gly Val Asp Lys 
            260                 265                 270         
Lys Arg Lys Arg Gly Met Pro Asp Val Leu Gly Glu Leu Asn Ser Ser 
        275                 280                 285             
Asp Pro His Gly Ile Glu Ser Lys Arg Arg Lys Lys Lys Pro Ala Ile 
    290                 295                 300                 
Leu Asp His Phe Leu Pro Ser His Gly Ser Gly Pro Phe Leu Pro Pro 
305                 310                 315                 320 
Ser Ala Leu Leu Pro Asp Pro Asp Phe Phe Ser Gly Thr Val Ser Leu 
                325                 330                 335     
Pro Gly Leu Glu Pro Pro Gly Gly Pro Asp Leu Leu Asp Asp Gly Phe 
            340                 345                 350         
Ala Tyr Asp Pro Thr Ala Pro Thr Leu Phe Thr Met Leu Asp Leu Leu 
        355                 360                 365             
Pro Pro Ala Pro Pro His Ala Ser Ala Val Val Cys Ser Ala Gly Ala 
    370                 375                 380                 
Val Val Gly Glu Thr Pro Gly Pro Glu Pro Leu Thr Leu Asp Ser Tyr 
385                 390                 395                 400 
Gln Ala Leu Gly Pro Gly Asp Gly Gly Thr Ala Ser Leu Val Gly Ser 
                405                 410                 415     
Asn Met Phe Pro Asn Gln Tyr Arg Glu Ala Ala Phe Gly Gly Gly Leu 
            420                 425                 430         
Leu Ser Pro Gly Pro Glu Ala Thr 
        435                 440 

<210> 20
<211> 541
<212> PRT
<213> Rhinopithecus roxellana


<220> 
<223> uniprot KB A0A2K6PBU2

<400> 20
Ser Pro Asp Leu Ser Ser Leu Ser Leu Thr Val Ser Arg Ser Thr Asp 
1               5                   10                  15      
Glu Leu Glu Ile Ile Asp Glu Tyr Ile Lys Glu Asn Gly Phe Gly Leu 
            20                  25                  30          
Asp Gly Gly Gln Ser Gly Pro Gly Glu Gly Leu Pro Arg Leu Val Ser 
        35                  40                  45              
Arg Gly Ala Ala Ser Leu Ser Thr Val Thr Leu Gly Pro Val Ala Pro 
    50                  55                  60                  
Pro Ala Thr Pro Pro Pro Trp Gly Cys Pro Leu Gly Arg Leu Val Pro 
65                  70                  75                  80  
Pro Thr Gln Gly Pro Gly Leu Gln Pro His Leu Val Ile Thr Glu Gln 
                85                  90                  95      
Pro Lys Gln Arg Gly Met Arg Phe Arg Tyr Glu Cys Glu Gly Arg Ser 
            100                 105                 110         
Ala Gly Ser Ile Leu Gly Glu Ser Ser Thr Glu Ala Ser Lys Thr Leu 
        115                 120                 125             
Pro Ala Ile Glu Leu Arg Asp Cys Gly Gly Leu Arg Glu Val Glu Val 
    130                 135                 140                 
Thr Ala Cys Leu Val Trp Lys Asp Trp Pro His Arg Val His Pro His 
145                 150                 155                 160 
Ser Leu Val Gly Lys Asp Cys Thr Asp Gly Val Cys Arg Val Arg Leu 
                165                 170                 175     
Arg Pro His Val Ser Pro Arg His Ser Phe Asn Asn Leu Gly Ile Gln 
            180                 185                 190         
Cys Val Arg Lys Lys Glu Ile Glu Ala Ala Ile Glu Arg Lys Ile Gln 
        195                 200                 205             
Leu Gly Ile Asp Pro Tyr Asn Ala Gly Ser Leu Lys Asn His Gln Glu 
    210                 215                 220                 
Val Asp Met Asn Val Val Arg Ile Cys Phe Gln Ala Ser Tyr Arg Asp 
225                 230                 235                 240 
Gln Gln Gly Gln Met Arg Arg Met Asp Pro Val Leu Ser Glu Pro Val 
                245                 250                 255     
Tyr Asp Lys Lys Ser Thr Asn Thr Ser Glu Leu Arg Ile Cys Arg Ile 
            260                 265                 270         
Asn Lys Glu Ser Gly Pro Cys Thr Gly Gly Glu Glu Leu Tyr Leu Leu 
        275                 280                 285             
Cys Asp Lys Val Gln Lys Glu Asp Ile Ser Val Val Phe Ser Arg Ala 
    290                 295                 300                 
Ser Trp Glu Gly Arg Ala Asp Phe Ser Gln Ala Asp Val His Arg Gln 
305                 310                 315                 320 
Ile Ala Ile Val Phe Lys Thr Pro Pro Tyr Glu Asp Leu Glu Ile Val 
                325                 330                 335     
Glu Pro Val Thr Val Asn Val Phe Leu Gln Arg Leu Thr Asp Gly Val 
            340                 345                 350         
Cys Ser Glu Pro Leu Pro Phe Thr Tyr Leu Pro Arg Asp His Asp Ser 
        355                 360                 365             
Tyr Gly Val Asp Lys Lys Arg Lys Arg Gly Met Pro Asp Val Leu Gly 
    370                 375                 380                 
Glu Leu Asn Ser Ser Asp Pro His Gly Ile Glu Ser Lys Arg Arg Lys 
385                 390                 395                 400 
Lys Lys Pro Ala Ile Leu Asp His Phe Leu Pro Ser His Gly Ser Gly 
                405                 410                 415     
Pro Phe Leu Pro Pro Ser Ala Leu Leu Pro Asp Pro Asp Phe Phe Ser 
            420                 425                 430         
Gly Thr Val Ser Leu Pro Gly Leu Glu Pro Pro Gly Gly Pro Asp Leu 
        435                 440                 445             
Leu Asp Asp Gly Phe Ala Tyr Asp Pro Thr Ala Pro Thr Leu Phe Thr 
    450                 455                 460                 
Met Leu Asp Leu Leu Pro Pro Ala Pro Pro His Ala Ser Ala Val Val 
465                 470                 475                 480 
Cys Ser Ala Gly Ala Val Val Gly Glu Pro Pro Gly Pro Glu Pro Leu 
                485                 490                 495     
Thr Leu Asp Ser Tyr Gln Ala Pro Gly Pro Gly Asp Gly Gly Thr Ala 
            500                 505                 510         
Ser Leu Val Gly Ser Asn Met Phe Pro Asn Gln Tyr Arg Glu Ala Ala 
        515                 520                 525             
Phe Gly Gly Gly Leu Leu Ser Pro Gly Pro Glu Ala Thr 
    530                 535                 540     

<210> 21
<211> 526
<212> PRT
<213> Macaca fascicularis


<220> 
<223> UniProtKB -A0A2K5V1L0

<400> 21
Asp Glu Leu Glu Ile Ile Asp Glu Tyr Ile Lys Glu Asn Gly Phe Gly 
1               5                   10                  15      
Leu Asp Gly Gly Gln Pro Gly Pro Gly Glu Gly Leu Pro Arg Leu Val 
            20                  25                  30          
Ser Arg Gly Ala Ala Ser Leu Ser Thr Val Thr Leu Gly Pro Val Ala 
        35                  40                  45              
Pro Pro Ala Thr Pro Pro Pro Trp Gly Cys Pro Leu Gly Arg Leu Val 
    50                  55                  60                  
Pro Pro Ala Gln Gly Pro Gly Pro Gln Pro His Leu Val Ile Thr Glu 
65                  70                  75                  80  
Gln Pro Lys Gln Arg Gly Met Arg Phe Arg Tyr Glu Cys Glu Gly Arg 
                85                  90                  95      
Ser Ala Gly Ser Ile Leu Gly Glu Ser Ser Thr Glu Ala Ser Lys Thr 
            100                 105                 110         
Leu Pro Ala Ile Glu Leu Arg Asp Cys Gly Gly Leu Arg Glu Val Glu 
        115                 120                 125             
Val Thr Ala Cys Leu Val Trp Lys Asp Trp Pro His Arg Val His Pro 
    130                 135                 140                 
His Ser Leu Val Gly Lys Asp Cys Thr Asp Gly Val Cys Arg Val Arg 
145                 150                 155                 160 
Leu Arg Pro His Val Ser Pro Arg His Ser Phe Asn Asn Leu Gly Ile 
                165                 170                 175     
Gln Cys Val Arg Lys Lys Glu Ile Glu Ala Ala Ile Glu Arg Lys Ile 
            180                 185                 190         
Gln Leu Gly Ile Asp Pro Tyr Asn Ala Gly Ser Leu Lys Asn His Gln 
        195                 200                 205             
Glu Val Asp Met Asn Val Val Arg Ile Cys Phe Gln Ala Ser Tyr Arg 
    210                 215                 220                 
Asp Gln Gln Gly Gln Met Arg Arg Met Asp Pro Val Leu Ser Glu Pro 
225                 230                 235                 240 
Val Tyr Asp Lys Lys Ser Thr Asn Thr Ser Glu Leu Arg Ile Cys Arg 
                245                 250                 255     
Ile Asn Lys Glu Ser Gly Pro Cys Thr Gly Gly Glu Glu Leu Tyr Leu 
            260                 265                 270         
Leu Cys Asp Lys Val Gln Lys Glu Asp Ile Ser Val Val Phe Ser Arg 
        275                 280                 285             
Ala Ser Trp Glu Gly Arg Ala Asp Phe Ser Gln Ala Asp Val His Arg 
    290                 295                 300                 
Gln Ile Ala Ile Val Phe Lys Thr Pro Pro Tyr Glu Asp Leu Glu Ile 
305                 310                 315                 320 
Val Glu Pro Val Thr Val Asn Val Phe Leu Gln Arg Leu Thr Asp Gly 
                325                 330                 335     
Val Cys Ser Glu Pro Leu Pro Phe Thr Tyr Leu Pro Arg Asp His Asp 
            340                 345                 350         
Ser Tyr Gly Val Asp Lys Lys Arg Lys Arg Gly Met Pro Asp Val Leu 
        355                 360                 365             
Gly Glu Leu Asn Ser Ser Asp Pro His Gly Ile Glu Ser Lys Arg Arg 
    370                 375                 380                 
Lys Lys Lys Pro Ala Ile Leu Asp His Phe Leu Pro Ser His Ser Ser 
385                 390                 395                 400 
Gly Pro Phe Leu Pro Pro Ser Ala Leu Leu Pro Asp Pro Asp Phe Phe 
                405                 410                 415     
Ser Gly Thr Val Ser Leu Pro Gly Leu Glu Pro Pro Gly Gly Pro Asp 
            420                 425                 430         
Leu Leu Asp Asp Gly Phe Ala Tyr Asp Pro Thr Ala Pro Thr Leu Phe 
        435                 440                 445             
Thr Met Leu Asp Leu Leu Pro Pro Ala Pro Pro His Ala Ser Ala Val 
    450                 455                 460                 
Val Cys Ser Ala Gly Ala Val Val Gly Glu Pro Pro Gly Pro Glu Pro 
465                 470                 475                 480 
Leu Thr Leu Asp Ser Tyr Gln Ala Pro Gly Pro Gly Asp Gly Gly Thr 
                485                 490                 495     
Ala Ser Leu Val Gly Ser Asn Met Phe Pro Asn Gln Tyr Arg Glu Ala 
            500                 505                 510         
Ala Phe Gly Gly Gly Leu Leu Ser Pro Gly Pro Glu Ala Thr 
        515                 520                 525     

<210> 22
<211> 522
<212> PRT
<213> Macaca fascicularis


<220> 
<223> UniProtKB - A0A2K5V1H3

<400> 22
Ile Ile Asp Glu Tyr Ile Lys Glu Asn Gly Phe Gly Leu Asp Gly Gly 
1               5                   10                  15      
Gln Pro Gly Pro Gly Glu Gly Leu Pro Arg Leu Val Ser Arg Gly Ala 
            20                  25                  30          
Ala Ser Leu Ser Thr Val Thr Leu Gly Pro Val Ala Pro Pro Ala Thr 
        35                  40                  45              
Pro Pro Pro Trp Gly Cys Pro Leu Gly Arg Leu Val Pro Pro Ala Gln 
    50                  55                  60                  
Gly Pro Gly Pro Gln Pro His Leu Val Ile Thr Glu Gln Pro Lys Gln 
65                  70                  75                  80  
Arg Gly Met Arg Phe Arg Tyr Glu Cys Glu Gly Arg Ser Ala Gly Ser 
                85                  90                  95      
Ile Leu Gly Glu Ser Ser Thr Glu Ala Ser Lys Thr Leu Pro Ala Ile 
            100                 105                 110         
Glu Leu Arg Asp Cys Gly Gly Leu Arg Glu Val Glu Val Thr Ala Cys 
        115                 120                 125             
Leu Val Trp Lys Asp Trp Pro His Arg Val His Pro His Ser Leu Val 
    130                 135                 140                 
Gly Lys Asp Cys Thr Asp Gly Val Cys Arg Val Arg Leu Arg Pro His 
145                 150                 155                 160 
Val Ser Pro Arg His Ser Phe Asn Asn Leu Gly Ile Gln Cys Val Arg 
                165                 170                 175     
Lys Lys Glu Ile Glu Ala Ala Ile Glu Arg Lys Ile Gln Leu Gly Ile 
            180                 185                 190         
Asp Pro Tyr Asn Ala Gly Ser Leu Lys Asn His Gln Glu Val Asp Met 
        195                 200                 205             
Asn Val Val Arg Ile Cys Phe Gln Ala Ser Tyr Arg Asp Gln Gln Gly 
    210                 215                 220                 
Gln Met Arg Arg Met Asp Pro Val Leu Ser Glu Pro Val Tyr Asp Lys 
225                 230                 235                 240 
Lys Ser Thr Asn Thr Ser Glu Leu Arg Ile Cys Arg Ile Asn Lys Glu 
                245                 250                 255     
Ser Gly Pro Cys Thr Gly Gly Glu Glu Leu Tyr Leu Leu Cys Asp Lys 
            260                 265                 270         
Val Gln Lys Glu Asp Ile Ser Val Val Phe Ser Arg Ala Ser Trp Glu 
        275                 280                 285             
Gly Arg Ala Asp Phe Ser Gln Ala Asp Val His Arg Gln Ile Ala Ile 
    290                 295                 300                 
Val Phe Lys Thr Pro Pro Tyr Glu Asp Leu Glu Ile Val Glu Pro Val 
305                 310                 315                 320 
Thr Val Asn Val Phe Leu Gln Arg Leu Thr Asp Gly Val Cys Ser Glu 
                325                 330                 335     
Pro Leu Pro Phe Thr Tyr Leu Pro Arg Asp His Asp Ser Tyr Gly Val 
            340                 345                 350         
Asp Lys Lys Arg Lys Arg Gly Met Pro Asp Val Leu Gly Glu Leu Asn 
        355                 360                 365             
Ser Ser Asp Pro His Gly Ile Glu Ser Lys Arg Arg Lys Lys Lys Pro 
    370                 375                 380                 
Ala Ile Leu Asp His Phe Leu Pro Ser His Ser Ser Gly Pro Phe Leu 
385                 390                 395                 400 
Pro Pro Ser Ala Leu Leu Pro Asp Pro Asp Phe Phe Ser Gly Thr Val 
                405                 410                 415     
Ser Leu Pro Gly Leu Glu Pro Pro Gly Gly Pro Asp Leu Leu Asp Asp 
            420                 425                 430         
Gly Phe Ala Tyr Asp Pro Thr Ala Pro Thr Leu Phe Thr Met Leu Asp 
        435                 440                 445             
Leu Leu Pro Pro Ala Pro Pro His Ala Ser Ala Val Val Cys Ser Ala 
    450                 455                 460                 
Gly Ala Val Val Gly Glu Pro Pro Gly Pro Glu Pro Leu Thr Leu Asp 
465                 470                 475                 480 
Ser Tyr Gln Ala Pro Gly Pro Gly Asp Gly Gly Thr Ala Ser Leu Val 
                485                 490                 495     
Gly Ser Asn Met Phe Pro Asn Gln Tyr Arg Glu Ala Ala Phe Gly Gly 
            500                 505                 510         
Gly Leu Leu Ser Pro Gly Pro Glu Ala Thr 
        515                 520         

<210> 23
<211> 548
<212> PRT
<213> Macaca fascicularis


<220> 
<223> uniprotKB A0A2K5CNM3

<220> 
<221> UNSURE
<222> 55..77
<223> Xaa

<400> 23
Met Leu Arg Ser Gly Arg Ala Ser Gly Pro Ser Val Pro Thr Gly Arg 
1               5                   10                  15      
Ala Met Pro Ser Arg Arg Val Ala Arg Pro Pro Ala Ala Ser Glu Leu 
            20                  25                  30          
Gly Ala Leu Gly Ser Pro Asp Leu Ser Ser Leu Ser Leu Ala Val Ser 
        35                  40                  45              
Arg Thr Thr Asp Glu Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Ser Leu 
65                  70                  75                  80  
Gly Arg Leu Val Pro Pro Ala Pro Gly Pro Gly Pro Gln Pro His Leu 
                85                  90                  95      
Val Ile Thr Glu Gln Pro Lys Gln Arg Gly Met Arg Phe Arg Tyr Glu 
            100                 105                 110         
Cys Glu Gly Arg Ser Ala Gly Ser Ile Leu Gly Glu Ser Ser Thr Glu 
        115                 120                 125             
Ala Ser Lys Thr Leu Pro Ala Ile Glu Leu Arg Asp Cys Gly Gly Leu 
    130                 135                 140                 
Arg Glu Val Glu Val Thr Ala Cys Leu Val Trp Lys Asp Trp Pro His 
145                 150                 155                 160 
Arg Val His Pro His Ser Leu Val Gly Lys Asp Cys Thr Asp Gly Val 
                165                 170                 175     
Cys Arg Val Arg Leu Arg Pro His Val Ser Pro Arg His Ser Phe Asn 
            180                 185                 190         
Asn Leu Gly Ile Gln Cys Val Arg Lys Lys Glu Ile Glu Ala Ala Ile 
        195                 200                 205             
Glu Arg Lys Ile Gln Leu Gly Ile Asp Pro Tyr Asn Ala Gly Ser Leu 
    210                 215                 220                 
Lys Asn His Gln Glu Val Asp Met Asn Val Val Arg Ile Cys Phe Gln 
225                 230                 235                 240 
Ala Ser Tyr Arg Asp Gln Gln Gly Gln Met Cys Arg Met Asp Pro Val 
                245                 250                 255     
Leu Ser Glu Pro Val Tyr Asp Lys Lys Ser Thr Asn Thr Ser Glu Leu 
            260                 265                 270         
Arg Ile Cys Arg Ile Asn Lys Glu Ser Gly Pro Cys Thr Gly Gly Glu 
        275                 280                 285             
Glu Leu Tyr Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile Ser Val 
    290                 295                 300                 
Val Phe Ser Thr Ala Ser Trp Glu Gly Arg Ala Asp Phe Ser Gln Ala 
305                 310                 315                 320 
Asp Val His Arg Gln Ile Ala Ile Val Phe Lys Thr Pro Pro Tyr Glu 
                325                 330                 335     
Asp Leu Glu Ile Val Glu Pro Val Thr Val Asn Val Phe Leu Gln Arg 
            340                 345                 350         
Leu Thr Asp Gly Val Cys Ser Glu Pro Leu Pro Phe Thr Tyr Leu Pro 
        355                 360                 365             
Arg Asp His Asp Ser Tyr Gly Val Asp Lys Lys Arg Lys Arg Gly Met 
    370                 375                 380                 
Pro Asp Val Leu Gly Glu Leu Asn Ser Ser Asp Pro His Gly Ile Glu 
385                 390                 395                 400 
Ser Lys Arg Arg Lys Lys Lys Pro Ala Phe Leu Asp His Phe Leu Pro 
                405                 410                 415     
Ser His Gly Ser Gly Pro Phe Leu Pro Pro Ser Ala Leu Leu Pro Asp 
            420                 425                 430         
Pro Asp Phe Phe Ser Gly Thr Val Ser Leu Pro Gly Leu Glu Pro Pro 
        435                 440                 445             
Gly Gly Pro Asp Leu Leu Asp Asp Gly Phe Ala Tyr Asp Pro Thr Ala 
    450                 455                 460                 
Ser Pro Leu Leu Thr Met Leu Asp Leu Leu Pro Pro Ala Pro Pro His 
465                 470                 475                 480 
Ala Ser Ala Val Val Cys Ser Gly Gly Ala Gly Ala Val Val Gly Glu 
                485                 490                 495     
Pro Pro Gly Pro Glu Pro Leu Thr Leu Asp Ser Tyr Gln Gly Pro Gly 
            500                 505                 510         
Pro Gly Asp Gly Gly Thr Ala Ser Leu Val Gly Ser Asn Met Phe Pro 
        515                 520                 525             
Asn Gln Tyr Arg Glu Ala Ala Phe Gly Gly Gly Leu Leu Ser Pro Gly 
    530                 535                 540                 
Pro Glu Ala Thr 
545             

<210> 24
<211> 538
<212> PRT
<213> Macaca fascicularis


<220> 
<223> uniprotKB A0A2K6M5W9

<400> 24
Ser Pro Asp Leu Ser Ser Leu Ser Leu Thr Val Ser Arg Ser Thr Glu 
1               5                   10                  15      
Ile Ile Asp Glu Tyr Ile Lys Glu Asn Gly Phe Gly Leu Asp Gly Gly 
            20                  25                  30          
Gln Ser Gly Pro Gly Glu Gly Leu Pro Arg Leu Val Ser Arg Gly Ala 
        35                  40                  45              
Ala Ser Leu Ser Thr Val Thr Leu Gly Pro Val Ala Pro Pro Ala Thr 
    50                  55                  60                  
Pro Pro Pro Trp Gly Cys Pro Leu Gly Arg Leu Val Pro Pro Thr Gln 
65                  70                  75                  80  
Gly Pro Gly Leu Gln Pro His Leu Val Ile Thr Glu Gln Pro Lys Gln 
                85                  90                  95      
Arg Gly Met Arg Phe Arg Tyr Glu Cys Glu Gly Arg Ser Ala Gly Ser 
            100                 105                 110         
Ile Leu Gly Glu Ser Ser Thr Glu Ala Ser Lys Thr Leu Pro Ala Ile 
        115                 120                 125             
Glu Leu Arg Asp Cys Gly Gly Leu Arg Glu Val Glu Val Thr Ala Cys 
    130                 135                 140                 
Leu Val Trp Lys Asp Trp Pro His Arg Val His Pro His Ser Leu Val 
145                 150                 155                 160 
Gly Lys Asp Cys Thr Asp Gly Val Cys Arg Val Arg Leu Arg Pro His 
                165                 170                 175     
Val Ser Pro Arg His Ser Phe Asn Asn Leu Gly Ile Gln Cys Val Arg 
            180                 185                 190         
Lys Lys Glu Ile Glu Ala Ala Ile Glu Arg Lys Ile Gln Leu Gly Ile 
        195                 200                 205             
Asp Pro Tyr Asn Ala Gly Ser Leu Lys Asn His Gln Glu Val Asp Met 
    210                 215                 220                 
Asn Val Val Arg Ile Cys Phe Gln Ala Ser Tyr Arg Asp Gln Gln Gly 
225                 230                 235                 240 
Gln Met Arg Arg Met Asp Pro Val Leu Ser Glu Pro Val Tyr Asp Lys 
                245                 250                 255     
Lys Ser Thr Asn Thr Ser Glu Leu Arg Ile Cys Arg Ile Asn Lys Glu 
            260                 265                 270         
Ser Gly Pro Cys Thr Gly Gly Glu Glu Leu Tyr Leu Leu Cys Asp Lys 
        275                 280                 285             
Val Gln Lys Glu Asp Ile Ser Val Val Phe Ser Arg Ala Ser Trp Glu 
    290                 295                 300                 
Gly Arg Ala Asp Phe Ser Gln Ala Asp Val His Arg Gln Ile Ala Ile 
305                 310                 315                 320 
Val Phe Lys Thr Pro Pro Tyr Glu Asp Leu Glu Ile Val Glu Pro Val 
                325                 330                 335     
Thr Val Asn Val Phe Leu Gln Arg Leu Thr Asp Gly Val Cys Ser Glu 
            340                 345                 350         
Pro Leu Pro Phe Thr Tyr Leu Pro Arg Asp His Asp Ser Tyr Gly Val 
        355                 360                 365             
Asp Lys Lys Arg Lys Arg Gly Met Pro Asp Val Leu Gly Glu Leu Asn 
    370                 375                 380                 
Ser Ser Asp Pro His Gly Ile Glu Ser Lys Arg Arg Lys Lys Lys Pro 
385                 390                 395                 400 
Ala Ile Leu Asp His Phe Leu Pro Ser His Gly Ser Gly Pro Phe Leu 
                405                 410                 415     
Pro Pro Ser Ala Leu Leu Pro Asp Pro Asp Phe Phe Ser Gly Thr Val 
            420                 425                 430         
Ser Leu Pro Gly Leu Glu Pro Pro Gly Gly Pro Asp Leu Leu Asp Asp 
        435                 440                 445             
Gly Phe Ala Tyr Asp Pro Thr Ala Pro Thr Leu Phe Thr Met Leu Asp 
    450                 455                 460                 
Leu Leu Pro Pro Ala Pro Pro His Ala Ser Ala Val Val Cys Ser Ala 
465                 470                 475                 480 
Gly Ala Val Val Gly Glu Pro Pro Gly Pro Glu Pro Leu Thr Leu Asp 
                485                 490                 495     
Ser Tyr Gln Ala Pro Gly Pro Gly Asp Gly Gly Thr Ala Ser Leu Val 
            500                 505                 510         
Gly Ser Asn Met Phe Pro Asn Gln Tyr Arg Glu Ala Ala Phe Gly Gly 
        515                 520                 525             
Gly Leu Leu Ser Pro Gly Pro Glu Ala Thr 
    530                 535             

<210> 25
<211> 576
<212> PRT
<213> Macaca fascicularis


<220> 
<223> uniprot KB A0A2K6UKH9

<220> 
<221> UNSURE
<222> 94..121
<223> Xaa

<400> 25
Met Leu Arg Ser Gly Arg Ala Ser Gly Pro Ser Val Pro Thr Gly Arg 
1               5                   10                  15      
Ala Met Pro Ser Arg Arg Val Ala Arg Pro Pro Ala Ala Ser Glu Leu 
            20                  25                  30          
Gly Ala Leu Gly Ser Pro Asp Leu Ser Ser Leu Ser Leu Ala Val Ser 
        35                  40                  45              
Arg Thr Thr Glu Ile Ile Asp Glu Tyr Ile Lys Glu Asn Gly Phe Gly 
    50                  55                  60                  
Leu Asp Arg Ala Gln Pro Gly Pro Gly Glu Gly Leu Pro Arg Leu Val 
65                  70                  75                  80  
Ser Arg Gly Ala Ala Ser Leu Ser Thr Val Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Gly Pro Gln Pro His Leu Val Ile Thr Glu 
        115                 120                 125             
Gln Pro Lys Gln Arg Gly Met Arg Phe Arg Tyr Glu Cys Glu Gly Arg 
    130                 135                 140                 
Ser Ala Gly Ser Ile Leu Gly Glu Ser Ser Thr Glu Ala Ser Lys Thr 
145                 150                 155                 160 
Leu Pro Ala Ile Glu Leu Arg Asp Cys Gly Gly Leu Arg Glu Val Glu 
                165                 170                 175     
Val Thr Ala Cys Leu Val Trp Lys Asp Trp Pro His Arg Val His Pro 
            180                 185                 190         
His Ser Leu Val Gly Lys Asp Cys Thr Asp Gly Val Cys Arg Val Arg 
        195                 200                 205             
Leu Arg Pro His Val Ser Pro Arg His Ser Phe Asn Asn Leu Gly Ile 
    210                 215                 220                 
Gln Cys Val Arg Lys Lys Glu Ile Glu Ala Ala Ile Glu Arg Lys Ile 
225                 230                 235                 240 
Gln Leu Gly Ile Asp Pro Tyr Asn Ala Gly Ser Leu Lys Asn His Gln 
                245                 250                 255     
Glu Val Asp Met Asn Val Val Arg Ile Cys Phe Gln Ala Ser Tyr Arg 
            260                 265                 270         
Asp Gln Gln Gly Gln Val Cys Arg Met Asp Pro Val Leu Ser Glu Pro 
        275                 280                 285             
Val Tyr Asp Lys Lys Ser Thr Asn Thr Ser Glu Leu Arg Ile Cys Arg 
    290                 295                 300                 
Ile Asn Lys Glu Ser Gly Pro Cys Thr Gly Gly Glu Glu Leu Tyr Leu 
305                 310                 315                 320 
Leu Cys Asp Lys Val Gln Lys Glu Asp Ile Ser Val Val Phe Ser Thr 
                325                 330                 335     
Ala Ser Trp Glu Gly Arg Ala Asp Phe Ser Gln Ala Asp Val His Arg 
            340                 345                 350         
Gln Ile Ala Ile Val Phe Lys Thr Pro Pro Tyr Glu Asp Leu Glu Ile 
        355                 360                 365             
Val Glu Pro Val Thr Val Asn Val Phe Leu Gln Arg Leu Thr Asp Gly 
    370                 375                 380                 
Val Cys Ser Glu Pro Leu Pro Phe Thr Tyr Leu Pro Arg Asp His Asp 
385                 390                 395                 400 
Ser Tyr Gly Val Asp Lys Lys Arg Lys Arg Gly Met Pro Asp Val Leu 
                405                 410                 415     
Gly Glu Leu Asn Ser Ser Asp Pro His Gly Ile Glu Ser Lys Arg Arg 
            420                 425                 430         
Lys Lys Lys Pro Ala Phe Leu Asp His Phe Leu Pro Ser His Gly Ser 
        435                 440                 445             
Gly Pro Phe Leu Pro Pro Ser Ala Leu Leu Pro Asp Pro Asp Phe Phe 
    450                 455                 460                 
Ser Gly Thr Val Ser Leu Pro Gly Leu Glu Pro Pro Gly Gly Pro Asp 
465                 470                 475                 480 
Leu Leu Asp Asp Gly Phe Ala Tyr Asp Pro Thr Ala Thr Pro Leu Leu 
                485                 490                 495     
Thr Met Leu Asp Leu Leu Pro Pro Ala Pro Pro His Ala Ser Ala Val 
            500                 505                 510         
Val Cys Ser Gly Gly Ala Gly Ala Val Val Gly Glu Pro Pro Gly Pro 
        515                 520                 525             
Glu Pro Leu Thr Leu Asp Ser Tyr Gln Gly Pro Gly Pro Gly Asp Gly 
    530                 535                 540                 
Gly Thr Ala Ser Leu Val Gly Ser Asn Met Phe Pro Asn Gln Tyr Arg 
545                 550                 555                 560 
Glu Ala Ala Phe Gly Gly Gly Leu Leu Ser Pro Gly Pro Glu Ala Thr 
                565                 570                 575     



<210> 26
<211> 538
<212> PRT
<213> Rhinopithecus roxellana


<220> 
<223> uniprot KB A0A2K6PBU6

<400> 26
Ser Pro Asp Leu Ser Ser Leu Ser Leu Thr Val Ser Arg Ser Thr Glu 
1               5                   10                  15      
Ile Ile Asp Glu Tyr Ile Lys Glu Asn Gly Phe Gly Leu Asp Gly Gly 
            20                  25                  30          
Gln Ser Gly Pro Gly Glu Gly Leu Pro Arg Leu Val Ser Arg Gly Ala 
        35                  40                  45              
Ala Ser Leu Ser Thr Val Thr Leu Gly Pro Val Ala Pro Pro Ala Thr 
    50                  55                  60                  
Pro Pro Pro Trp Gly Cys Pro Leu Gly Arg Leu Val Pro Pro Thr Gln 
65                  70                  75                  80  
Gly Pro Gly Leu Gln Pro His Leu Val Ile Thr Glu Gln Pro Lys Gln 
                85                  90                  95      
Arg Gly Met Arg Phe Arg Tyr Glu Cys Glu Gly Arg Ser Ala Gly Ser 
            100                 105                 110         
Ile Leu Gly Glu Ser Ser Thr Glu Ala Ser Lys Thr Leu Pro Ala Ile 
        115                 120                 125             
Glu Leu Arg Asp Cys Gly Gly Leu Arg Glu Val Glu Val Thr Ala Cys 
    130                 135                 140                 
Leu Val Trp Lys Asp Trp Pro His Arg Val His Pro His Ser Leu Val 
145                 150                 155                 160 
Gly Lys Asp Cys Thr Asp Gly Val Cys Arg Val Arg Leu Arg Pro His 
                165                 170                 175     
Val Ser Pro Arg His Ser Phe Asn Asn Leu Gly Ile Gln Cys Val Arg 
            180                 185                 190         
Lys Lys Glu Ile Glu Ala Ala Ile Glu Arg Lys Ile Gln Leu Gly Ile 
        195                 200                 205             
Asp Pro Tyr Asn Ala Gly Ser Leu Lys Asn His Gln Glu Val Asp Met 
    210                 215                 220                 
Asn Val Val Arg Ile Cys Phe Gln Ala Ser Tyr Arg Asp Gln Gln Gly 
225                 230                 235                 240 
Gln Met Arg Arg Met Asp Pro Val Leu Ser Glu Pro Val Tyr Asp Lys 
                245                 250                 255     
Lys Ser Thr Asn Thr Ser Glu Leu Arg Ile Cys Arg Ile Asn Lys Glu 
            260                 265                 270         
Ser Gly Pro Cys Thr Gly Gly Glu Glu Leu Tyr Leu Leu Cys Asp Lys 
        275                 280                 285             
Val Gln Lys Glu Asp Ile Ser Val Val Phe Ser Arg Ala Ser Trp Glu 
    290                 295                 300                 
Gly Arg Ala Asp Phe Ser Gln Ala Asp Val His Arg Gln Ile Ala Ile 
305                 310                 315                 320 
Val Phe Lys Thr Pro Pro Tyr Glu Asp Leu Glu Ile Val Glu Pro Val 
                325                 330                 335     
Thr Val Asn Val Phe Leu Gln Arg Leu Thr Asp Gly Val Cys Ser Glu 
            340                 345                 350         
Pro Leu Pro Phe Thr Tyr Leu Pro Arg Asp His Asp Ser Tyr Gly Val 
        355                 360                 365             
Asp Lys Lys Arg Lys Arg Gly Met Pro Asp Val Leu Gly Glu Leu Asn 
    370                 375                 380                 
Ser Ser Asp Pro His Gly Ile Glu Ser Lys Arg Arg Lys Lys Lys Pro 
385                 390                 395                 400 
Ala Ile Leu Asp His Phe Leu Pro Ser His Gly Ser Gly Pro Phe Leu 
                405                 410                 415     
Pro Pro Ser Ala Leu Leu Pro Asp Pro Asp Phe Phe Ser Gly Thr Val 
            420                 425                 430         
Ser Leu Pro Gly Leu Glu Pro Pro Gly Gly Pro Asp Leu Leu Asp Asp 
        435                 440                 445             
Gly Phe Ala Tyr Asp Pro Thr Ala Pro Thr Leu Phe Thr Met Leu Asp 
    450                 455                 460                 
Leu Leu Pro Pro Ala Pro Pro His Ala Ser Ala Val Val Cys Ser Ala 
465                 470                 475                 480 
Gly Ala Val Val Gly Glu Pro Pro Gly Pro Glu Pro Leu Thr Leu Asp 
                485                 490                 495     
Ser Tyr Gln Ala Pro Gly Pro Gly Asp Gly Gly Thr Ala Ser Leu Val 
            500                 505                 510         
Gly Ser Asn Met Phe Pro Asn Gln Tyr Arg Glu Ala Ala Phe Gly Gly 
        515                 520                 525             
Gly Leu Leu Ser Pro Gly Pro Glu Ala Thr 
    530                 535             

<210> 27
<211> 419
<212> PRT
<213> Macaca fascicularis


<220> 
<223> uniprot KB G7PXV8

<400> 27
Glu Leu Gln Arg Ala Leu Leu Phe Leu Gln Leu Arg Asp Cys Gly Gly 
1               5                   10                  15      
Leu Arg Glu Val Glu Val Thr Ala Cys Leu Val Trp Lys Asp Trp Pro 
            20                  25                  30          
His Arg Val His Pro His Ser Leu Val Gly Lys Asp Cys Thr Asp Gly 
        35                  40                  45              
Val Cys Arg Val Arg Leu Arg Pro His Val Ser Pro Arg His Ser Phe 
    50                  55                  60                  
Asn Asn Leu Gly Ile Gln Cys Val Arg Lys Lys Glu Ile Glu Ala Ala 
65                  70                  75                  80  
Ile Glu Arg Lys Ile Gln Leu Gly Ile Asp Pro Tyr Asn Ala Gly Ser 
                85                  90                  95      
Leu Lys Asn His Gln Glu Val Asp Met Asn Val Val Arg Ile Cys Phe 
            100                 105                 110         
Gln Ala Ser Tyr Arg Asp Gln Gln Gly Gln Met Arg Arg Met Asp Pro 
        115                 120                 125             
Val Leu Ser Glu Pro Val Tyr Asp Lys Lys Ser Thr Asn Thr Ser Glu 
    130                 135                 140                 
Leu Arg Ile Cys Arg Ile Asn Lys Glu Ser Gly Pro Cys Thr Gly Gly 
145                 150                 155                 160 
Glu Glu Leu Tyr Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile Ser 
                165                 170                 175     
Val Val Phe Ser Arg Ala Ser Trp Glu Gly Arg Ala Asp Phe Ser Gln 
            180                 185                 190         
Ala Asp Val His Arg Gln Ile Ala Ile Val Phe Lys Thr Pro Pro Tyr 
        195                 200                 205             
Glu Asp Leu Glu Ile Val Glu Pro Val Thr Val Asn Val Phe Leu Gln 
    210                 215                 220                 
Arg Leu Thr Asp Gly Val Cys Ser Glu Pro Leu Pro Phe Thr Tyr Leu 
225                 230                 235                 240 
Pro Arg Asp His Asp Ser Tyr Gly Val Asp Lys Lys Arg Lys Arg Gly 
                245                 250                 255     
Met Pro Asp Val Leu Gly Glu Leu Asn Ser Ser Asp Pro His Gly Ile 
            260                 265                 270         
Glu Ser Lys Arg Arg Lys Lys Lys Pro Ala Ile Leu Asp His Phe Leu 
        275                 280                 285             
Pro Ser His Ser Ser Gly Pro Phe Leu Pro Pro Ser Ala Leu Leu Pro 
    290                 295                 300                 
Asp Pro Asp Phe Phe Ser Gly Thr Val Ser Leu Pro Gly Leu Glu Pro 
305                 310                 315                 320 
Pro Gly Gly Pro Asp Leu Leu Asp Asp Gly Phe Ala Tyr Asp Pro Thr 
                325                 330                 335     
Ala Pro Thr Leu Phe Thr Met Leu Asp Leu Leu Pro Pro Ala Pro Pro 
            340                 345                 350         
His Ala Ser Ala Val Val Cys Ser Ala Gly Ala Val Val Gly Glu Pro 
        355                 360                 365             
Pro Gly Pro Glu Pro Leu Thr Leu Asp Ser Tyr Gln Ala Pro Gly Pro 
    370                 375                 380                 
Gly Asp Gly Gly Thr Ala Ser Leu Val Gly Ser Asn Met Phe Pro Asn 
385                 390                 395                 400 
Gln Tyr Arg Glu Ala Ala Phe Gly Gly Gly Leu Leu Ser Pro Gly Pro 
                405                 410                 415     
Glu Ala Thr 
            

