                         SEQUENCE LISTING

<110>  Rheinische Friedrich-Wilhelms-Universität Bonn
 
<120>  CORONA VIRUS SPIKE PROTEIN BINDING COMPOUNDS

<130>  U31021WO

<150>  EP20208417.4
<151>  2020-11-18

<160>  104   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Phe Thr Leu Asp Asp Tyr Ala 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Ser Ser Ser Asp Gly Ser Thr 
1               5               


<210>  3
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Ala Thr Tyr Trp Ser Gly Ser Val Trp Tyr Met Asp Ala Glu Glu 
1               5                   10                  15      


Tyr Asp Tyr 
            


<210>  4
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Ala Arg Phe Ala Ile Ser Ser Asp Asn Ala Lys Asn Val Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr Tyr Trp Ser Gly Ser Val Trp Tyr Met Asp Ala Glu Glu 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ala 
        115                 120                 125     


<210>  5
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Phe Gly Tyr Asp Asp His Val 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile Ser Thr Asp Asp Gly Ser Thr 
1               5               


<210>  7
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Ala Thr Lys Gly Trp His Thr Glu Tyr Asp Leu Lys Arg Leu Arg 
1               5                   10                  15      


Asp Phe Asp Phe Glu Thr 
            20          


<210>  8
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ile Leu Ser Cys Gln Val Asp Gly Phe Gly Tyr Asp Asp His 
            20                  25                  30          


Val Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Tyr Ile Ser Thr Asp Asp Asp Arg Ser Thr Trp Tyr Ala Glu Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Ala Ile Ser Lys Asp Ser Ala Glu Asp Thr Thr 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Thr Lys Gly Trp His Thr Glu Tyr Asp Leu Lys Arg Leu 
            100                 105                 110         


Arg Asp Phe Asp Phe Glu Thr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  9
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly Phe Thr Leu Asp Tyr Tyr Ala 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  10

Val Ser Ser Ser Asp Gly Ser Thr 
1               5               


<210>  11
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala His Lys Gln Arg Asp Ile Cys Ser Gly Tyr Glu Phe Leu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  12
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Val Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala His Lys Gln Arg Asp Ile Cys Ser Gly Tyr Glu Phe Leu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  13
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Arg Thr Phe Gly Ser Tyr Ala 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Thr Trp Ser Ser Met Ser Pro 
1               5               


<210>  15
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Ala Val Gly Leu Ser Val Pro Phe Ile Glu Thr His Glu His Glu 
1               5                   10                  15      


Tyr Asp Tyr 
            


<210>  16
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Arg Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Gly Ser Tyr 
            20                  25                  30          


Ala Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Met Thr Trp Ser Ser Met Ser Pro Asn Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Ala Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Gly Leu Ser Val Pro Phe Ile Glu Thr His Glu His Glu 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  17
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Val Thr Leu Asp Tyr Tyr Ala 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  18

Ile Gly Ser Ser Asp Gly Arg Thr 
1               5               


<210>  19
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Leu Thr Val Gly Thr Tyr Tyr Ser Gly Asn Tyr His Tyr Thr Cys 
1               5                   10                  15      


Ser Asp Asp Met Asp Tyr 
            20          


<210>  20
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Gly Ser Ser Asp Gly Arg Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Thr Val Gly Thr Tyr Tyr Ser Gly Asn Tyr His Tyr Thr Cys 
            100                 105                 110         


Ser Asp Asp Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  21
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  21

Gly Arg Thr Phe Ser Asp Tyr Ala 
1               5               


<210>  22
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  22

Ile Gly Gly Gly Ser Ile 
1               5       


<210>  23
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Val Ala Val Gly Ala Thr Thr Arg Pro Ser Trp Arg Ser Arg Val 
1               5                   10                  15      


Ala Glu Val Tyr Tyr Asp Tyr 
            20              


<210>  24
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Arg Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Gly Gly Gly Ser Ile Tyr Tyr Ala Glu Ser Val Glu Gly 
    50                  55                  60                  


Arg Phe Ala Ile Ser Arg Asp Asn Ala Arg Asn Thr Ala Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ala Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys Ala Val 
                85                  90                  95      


Ala Val Gly Ala Thr Thr Arg Pro Ser Trp Arg Ser Arg Val Ala Glu 
            100                 105                 110         


Val Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Arg Val Thr Val Thr Thr 
        115                 120                 125             


<210>  25
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  25

Glu Asp Thr Asp Ala 
1               5   


<210>  26
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  26

Ile Thr Trp Asn Ala Asp Arg Thr 
1               5               


<210>  27
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Ala Ala Val Gly Gly Ser Tyr Tyr Pro Pro Val Pro Ser Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  28
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Asp Thr Asp Ala Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Thr Ile 
        35                  40                  45              


Thr Trp Asn Ala Asp Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Ala Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala 
                85                  90                  95      


Val Gly Gly Ser Tyr Tyr Pro Pro Val Pro Ser Glu Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  29
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Asn Ile Val Asn Phe Gly Ser 
1               5               


<210>  30
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  30

Ile Thr Asp Gly Gly Ser Thr 
1               5           


<210>  31
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  31

Val Ala Ala Arg Ser Asn Leu Ala Gly Trp Gly Glu Asp Phe Asp Ser 
1               5                   10                  15      


<210>  32
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Thr Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Asn Ile Val Asn Phe Gly 
            20                  25                  30          


Ser Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Asp Gly Gly Ser Thr Ile Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe Met 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Ala Asp Ser Ala Thr Tyr Tyr Cys Val 
                85                  90                  95      


Ala Ala Arg Ser Asn Leu Ala Gly Trp Gly Glu Asp Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  33
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  33

Gly Ser Ile Phe Ser Ile Gln Ala 
1               5               


<210>  34
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  34

Ile Gly Ala Ser Gly Asn Thr 
1               5           


<210>  35
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  35

Tyr Ala Leu Thr Arg Leu Pro Leu Pro Asp Gly Met Asp Tyr 
1               5                   10                  


<210>  36
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Ser Ile Gln 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Gly Ala Ser Gly Asn Thr Lys Tyr Gly Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Glu Glu Asn Lys Val Tyr Val 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Thr Glu Asp Thr Ala Val Tyr Arg Cys Tyr 
                85                  90                  95      


Ala Leu Thr Arg Leu Pro Leu Pro Asp Gly Met Asp Tyr Trp Gly Glu 
            100                 105                 110         


Gly Thr Pro Val Thr Val Ser Ser 
        115                 120 


<210>  37
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  37

Gly Arg Ala Tyr Ala 
1               5   


<210>  38
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  38

Ile Leu Trp Ser Gly Ala Ser 
1               5           


<210>  39
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  39

Ala Ala Asp Leu Gln Phe Pro Leu Thr Thr Pro Gln Phe His Glu Tyr 
1               5                   10                  15      


Asp Val 
        


<210>  40
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  40

Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Arg Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Arg Ala Tyr Ala Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile 
        35                  40                  45              


Leu Trp Ser Gly Ala Ser Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
    50                  55                  60                  


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
65                  70                  75                  80  


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Leu Gln 
                85                  90                  95      


Phe Pro Leu Thr Thr Pro Gln Phe His Glu Tyr Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  41
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  41

Gly Arg Ala Phe Asn Asn Asn Gly 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  42

Ile Asn Trp Ser Gly Tyr Ser Thr 
1               5               


<210>  43
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  43

Ala Ala Ser Leu Gly Ser Ser Trp Tyr Ser His Asp Ala Asn Asp Tyr 
1               5                   10                  15      


Pro Tyr 
        


<210>  44
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Asn Asn Asn 
            20                  25                  30          


Gly Ile Ala Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Asn Trp Ser Gly Tyr Ser Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Ser Val Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Glu Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Leu Gly Ser Ser Trp Tyr Ser His Asp Ala Asn Asp Tyr 
            100                 105                 110         


Pro Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  45
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  45

Ala Phe Thr Phe Gly Tyr Tyr Ala 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  46

Ile Asn Tyr Asn Gly Arg Asp Thr 
1               5               


<210>  47
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  47

Ala Ala Glu Arg Ala Ser Ile Cys Thr Leu Gln Ala Asp Pro Tyr Glu 
1               5                   10                  15      


Tyr 
    


<210>  48
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ser Ser Ala Phe Thr Phe Gly Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ala Cys Ile Asn Tyr Asn Gly Arg Asp Thr Asn Phe Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Lys Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asn Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Arg Ala Ser Ile Cys Thr Leu Gln Ala Asp Pro Tyr Glu 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr His Val Thr Val Ser Ser 
        115                 120                 


<210>  49
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  49

Gly Ile Leu Phe Asp Tyr Phe Ala 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  50

Ile Asn Tyr Asn Gly Arg Asp Thr 
1               5               


<210>  51
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  51

Ala Ala Glu Arg Ala Ser Ile Cys Thr Leu Gln Glu Asp Pro Tyr Glu 
1               5                   10                  15      


Tyr 
    


<210>  52
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  52

Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Ala Ser Ser Gly Ile Leu Phe Asp Tyr Phe 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Asn Tyr Asn Gly Arg Asp Thr Asn Phe Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Lys Thr Val His 
65                  70                  75                  80  


Leu Gln Met Lys Asp Leu Lys Pro Glu Asp Thr Gly Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ala Glu Arg Ala Ser Ile Cys Thr Leu Gln Glu Asp Pro Tyr Glu 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  53
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  53

Gly Asp Thr Leu Asp Tyr Tyr Ser 
1               5               


<210>  54
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Thr Arg Asn Gly Arg Ile 
1               5           


<210>  55
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  55

Ala Ala Pro Glu Arg Phe Arg Leu Cys Thr Leu Arg Ser Leu Thr Asp 
1               5                   10                  15      


Phe Gly Ala 
            


<210>  56
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Asp Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ser Ile Val Trp Phe Arg Arg Ser Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Met Thr Arg Asn Gly Arg Ile Glu Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Pro Glu Arg Phe Arg Leu Cys Thr Leu Arg Ser Leu Thr Asp Phe 
            100                 105                 110         


Gly Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  57
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  57

Gly Phe Thr Leu Asp Tyr Tyr Ala 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  58

Ile Ser Ser Ser Gly Gly Ser Thr 
1               5               


<210>  59
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  59

Ala Ala Asp Arg Gly Ile His Ser Glu Cys Ser Ser Trp Ser Ala Asp 
1               5                   10                  15      


Phe Ala Ser 
            


<210>  60
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  60

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Arg Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Gly Ile His Ser Glu Cys Ser Ser Trp Ser Ala Asp 
            100                 105                 110         


Phe Ala Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  61
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  61

Gly Phe Ile Leu Asp Tyr Tyr Asp 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  62

Ile Ser Ser Ser Gly Ser Thr Thr 
1               5               


<210>  63
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  63

Val Leu Asp Pro Pro Cys His Gln Ser Glu Ser Ala Leu His Tyr Glu 
1               5                   10                  15      


Arg Ala Phe 
            


<210>  64
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  64

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Leu Ser Gly Phe Ile Leu Asp Tyr Tyr 
            20                  25                  30          


Asp Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Ser Thr Thr Tyr Tyr Gly Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Ala Glu Asp Thr Gly Arg Tyr Tyr Cys 
                85                  90                  95      


Val Leu Asp Pro Pro Cys His Gln Ser Glu Ser Ala Leu His Tyr Glu 
            100                 105                 110         


Arg Ala Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  65
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  65

Gly Arg Thr Thr Arg Asn Asp Ala 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  66

Ile Ser Trp Asn Gly Arg Asn Thr 
1               5               


<210>  67
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  67

Ala Ile Gly Ile Asn Asp Tyr Gly Val Pro Ser Arg Pro Asn Met Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  68
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  68

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Arg Thr Thr Arg Asn Asp 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Asn Gly Arg Asn Thr Ala Tyr Ala Asp Ser Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Lys Pro Asp Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Gly Ile Asn Asp Tyr Gly Val Pro Ser Arg Pro Asn Met Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  69
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  69

Gly Phe Thr Leu Asp Tyr Tyr Ala 
1               5               


<210>  70
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  70

Ile Ser Ser Gly Gly Gly Tyr Thr 
1               5               


<210>  71
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  71

Ala Ala Asp Asp Pro His Pro Gln Gly Pro Asp Val Cys Ser Asp Ser 
1               5                   10                  15      


Trp Leu Glu Tyr Arg Tyr Arg Glu Leu 
            20                  25  


<210>  72
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  72

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Gly Gly Gly Tyr Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Asp Pro His Pro Gln Gly Pro Asp Val Cys Ser Asp Ser 
            100                 105                 110         


Trp Leu Glu Tyr Arg Tyr Arg Glu Leu Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  73
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  73

Glu Ser Ile Leu Glu Asn Asn Asn 
1               5               


<210>  74
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  74

Ile Ser Asn Ser Gly Gly Ala 
1               5           


<210>  75
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  75

Leu Arg Ala His Ile Thr Pro Ser Arg Cys Leu Asp Phe Gly Ala 
1               5                   10                  15  


<210>  76
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  76

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Glu Ser Ile Leu Glu Asn Asn 
            20                  25                  30          


Asn Val Gly Trp Phe Arg Gln Gly Pro Gly Glu Glu His Glu Ala Val 
        35                  40                  45              


Ser Cys Ile Ser Asn Ser Gly Gly Ala Phe Tyr Tyr Gly Ser Gly Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Thr Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


His Met Arg Asp Leu Lys His Glu Asp Ser Gly Ile Tyr His Cys Leu 
                85                  90                  95      


Arg Ala His Ile Thr Pro Ser Arg Cys Leu Asp Phe Gly Ala Val Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  77
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  77

Gly Phe Ser Leu Asp Tyr Tyr Ala 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  78

Ile Ser Ser Ser Gly Gly Ser Thr 
1               5               


<210>  79
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  79

Ala Ala Ala Pro Ser Thr Tyr Tyr Gly Gly Ser Tyr Tyr His Gln Cys 
1               5                   10                  15      


Leu Glu Tyr Asp Tyr 
            20      


<210>  80
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  80

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Pro Ser Thr Tyr Tyr Gly Gly Ser Tyr Tyr His Gln Cys 
            100                 105                 110         


Leu Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  81
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  81

Gly Phe Thr Leu Asp Tyr Tyr Ala 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  82

Ile Ser Ser Ser Gly Gly Ser Thr 
1               5               


<210>  83
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  83

Ala Ala Gln Ser Gly Ser Tyr Tyr Trp Cys Gly Ser Asp Trp His Glu 
1               5                   10                  15      


Tyr Glu Tyr 
            


<210>  84
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  84

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Gly Ser Thr His Phe Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Ile Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gln Ser Gly Ser Tyr Tyr Trp Cys Gly Ser Asp Trp His Glu 
            100                 105                 110         


Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  85
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  85

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  86
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  86

Ile Tyr Ser Asp Gly Ser Thr 
1               5           


<210>  87
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  87

Ala Thr Glu Gly Ser Leu Gly Gly Trp Gly Arg Asp Phe Gly Ser 
1               5                   10                  15  


<210>  88
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  88

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Ala Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Tyr Ser Asp Gly Ser Thr Glu Tyr Gln Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gly Ser Leu Gly Gly Trp Gly Arg Asp Phe Gly Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  89
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  89

Gly Phe Thr Leu Asp Tyr Tyr Ala 
1               5               


<210>  90
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  90

Ile Ser Ser Ser Gly Asp Ser Thr 
1               5               


<210>  91
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  91

Ala Ala Gln Ser Gly Ser Tyr Tyr Trp Cys Gly Ser Asp Trp His Glu 
1               5                   10                  15      


Tyr Asp Tyr 
            


<210>  92
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  92

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Asp Ser Thr His Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gln Ser Gly Ser Tyr Tyr Trp Cys Gly Ser Asp Trp His Glu 
            100                 105                 110         


Tyr Asp Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  93
<211>  1273
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  94
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  94

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  95
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  95

Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
1               5                   10                  15      


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
            20                  25                  30          


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
        35                  40                  45              


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
    50                  55                  60                  


Asn Gly Val Gly Tyr Gln Pro Tyr 
65                  70          


<210>  96
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  96
actgctggaa tggcaggaac                                                   20


<210>  97
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  97
tctgagcgag acaaagtgca cc                                                22


<210>  98
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  98
atgctgcaat cgtgctacaa                                                   20


<210>  99
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  99
gactgccgcc tctgctc                                                      17


<210>  100
<211>  283
<212>  PRT
<213>  Homo Sapiens

<400>  100

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Ala Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Tyr Ser Asp Gly Ser Thr Glu Tyr Gln Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gly Ser Leu Gly Gly Trp Gly Arg Asp Phe Gly Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Thr Gly 
    130                 135                 140                 


Gly Gly Phe Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
145                 150                 155                 160 


Ser Gly Val Thr Leu Asp Tyr Tyr Ala Ile Gly Trp Phe Arg Gln Ala 
                165                 170                 175     


Pro Gly Lys Glu Arg Glu Gly Val Ser Cys Ile Gly Ser Ser Asp Gly 
            180                 185                 190         


Arg Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu Thr Val Gly Thr Tyr Tyr 
225                 230                 235                 240 


Ser Gly Asn Tyr His Tyr Thr Cys Ser Asp Asp Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Tyr Pro Tyr Asp Val 
            260                 265                 270         


Pro Asp Tyr Ala Gly His His His His His His 
        275                 280             


<210>  101
<211>  283
<212>  PRT
<213>  Homo Sapiens

<400>  101

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Ala Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Tyr Ser Asp Gly Ser Thr Glu Tyr Gln Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gly Ser Leu Gly Gly Trp Gly Arg Asp Phe Gly Ser Trp Gly 
            100                 105                 110         


Cys Gly Thr Cys Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Cys 
        115                 120                 125             


Gly Gly Gly Gly Cys Gly Gly Ser Gln Val Gln Leu Val Glu Thr Gly 
    130                 135                 140                 


Gly Gly Phe Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
145                 150                 155                 160 


Ser Gly Val Thr Leu Asp Tyr Tyr Ala Ile Gly Trp Phe Arg Gln Ala 
                165                 170                 175     


Pro Gly Lys Glu Arg Glu Gly Val Ser Cys Ile Gly Ser Ser Asp Gly 
            180                 185                 190         


Arg Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu Thr Val Gly Thr Tyr Tyr 
225                 230                 235                 240 


Ser Gly Asn Tyr His Tyr Thr Cys Ser Asp Asp Met Asp Tyr Trp Gly 
                245                 250                 255     


Lys Gly Thr Gln Val Thr Val Ser Ser Gly Thr Tyr Pro Tyr Asp Val 
            260                 265                 270         


Pro Asp Tyr Ala Gly His His His His His His 
        275                 280             


<210>  102
<211>  283
<212>  PRT
<213>  Homo Sapiens

<400>  102

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Ala Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Tyr Ser Asp Gly Ser Thr Glu Tyr Gln Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gly Ser Leu Gly Gly Trp Gly Arg Asp Phe Gly Ser Trp Gly 
            100                 105                 110         


Cys Gly Thr Cys Val Thr Val Ser Ser Gly Gly Gly Gly Cys Gly Gly 
        115                 120                 125             


Gly Gly Gly Cys Gly Gly Gly Ser Gln Val Gln Leu Val Glu Thr Gly 
    130                 135                 140                 


Gly Gly Phe Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
145                 150                 155                 160 


Ser Gly Val Thr Leu Asp Tyr Tyr Ala Ile Gly Trp Phe Arg Gln Ala 
                165                 170                 175     


Pro Gly Lys Glu Arg Glu Gly Val Ser Cys Ile Gly Ser Ser Asp Gly 
            180                 185                 190         


Arg Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu Thr Val Gly Thr Tyr Tyr 
225                 230                 235                 240 


Ser Gly Asn Tyr His Tyr Thr Cys Ser Asp Asp Met Asp Tyr Trp Gly 
                245                 250                 255     


Lys Gly Thr Gln Val Thr Val Ser Ser Gly Thr Tyr Pro Tyr Asp Val 
            260                 265                 270         


Pro Asp Tyr Ala Gly His His His His His His 
        275                 280             


<210>  103
<211>  283
<212>  PRT
<213>  Homo Sapiens

<400>  103

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Ala Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Tyr Ser Asp Gly Ser Thr Glu Tyr Leu Asn Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gly Ser Leu Gly Gly Asn Gly Arg Asp Phe Gly Ser Trp Gly 
            100                 105                 110         


Cys Gly Thr Cys Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Cys 
        115                 120                 125             


Gly Gly Gly Gly Cys Gly Gly Ser Gln Val Gln Leu Val Glu Thr Gly 
    130                 135                 140                 


Gly Gly Phe Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
145                 150                 155                 160 


Ser Gly Val Thr Leu Asp Tyr Tyr Ala Ile Gly Trp Phe Arg Gln Ala 
                165                 170                 175     


Pro Gly Lys Glu Arg Glu Gly Val Ser Cys Ile Gly Ser Ser Asp Gly 
            180                 185                 190         


Arg Thr Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu Thr Val Gly Thr Tyr Tyr 
225                 230                 235                 240 


Ser Gly Asn Tyr His Tyr Thr Cys Ser Asp Asp Met Asp Tyr Trp Gly 
                245                 250                 255     


Lys Gly Thr Gln Val Thr Val Ser Ser Gly Thr Tyr Pro Tyr Asp Val 
            260                 265                 270         


Pro Asp Tyr Ala Gly His His His His His His 
        275                 280             


<210>  104
<211>  283
<212>  PRT
<213>  Homo Sapiens

<400>  104

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Ala Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Tyr Ser Asp Gly Ser Thr Glu Tyr Leu Asn Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Glu Gly Ser Leu Gly Gly Asn Gly Arg Asp Phe Gly Ser Trp Gly 
            100                 105                 110         


Cys Gly Thr Cys Val Thr Val Ser Ser Gly Gly Gly Gly Cys Gly Gly 
        115                 120                 125             


Gly Gly Gly Cys Gly Gly Gly Ser Gln Val Gln Leu Val Glu Thr Gly 
    130                 135                 140                 


Gly Gly Phe Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
145                 150                 155                 160 


Ser Gly Val Thr Leu Asp Tyr Tyr Ala Ile Gly Trp Phe Arg Gln Ala 
                165                 170                 175     


Pro Gly Lys Glu Arg Glu Gly Val Ser Cys Ile Gly Ser Ser Asp Gly 
            180                 185                 190         


Arg Thr Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu Thr Val Gly Thr Tyr Tyr 
225                 230                 235                 240 


Ser Gly Asn Tyr His Tyr Thr Cys Ser Asp Asp Met Asp Tyr Trp Gly 
                245                 250                 255     


Lys Gly Thr Gln Val Thr Val Ser Ser Gly Thr Tyr Pro Tyr Asp Val 
            260                 265                 270         


Pro Asp Tyr Ala Gly His His His His His His 
        275                 280             


