                         SEQUENCE LISTING

<110>   Sunshine Lake Pharma Co., Ltd.
 
<120>  HUMANIZED ANTI-TRKA ANTIBODIES AND USES THEREOF

<130>  2021.11.18

<160>  49    

<170>  PatentIn version 3.3

<210>  1
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  1

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Met Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Leu Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  2
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  2

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Met Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Leu Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  3
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  3

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Met Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Leu Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  4
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  4

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Met Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  5
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Met Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  6
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Met Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Ile Thr Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  7
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Ile Thr Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  8
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Met Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Leu Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  9
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region

<400>  9

Ser Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Gly Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Ala Tyr His Cys Gly Gln Asn Tyr Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region

<400>  10

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Gly Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Ala Tyr His Cys Gly Gln Asn Tyr Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  11
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region

<400>  11

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Gly Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Ala Tyr His Cys Gly Gln Asn Tyr Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region

<400>  12

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Gly Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg His Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr His Cys Gly Gln Asn Tyr Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  13
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region

<400>  13

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Gly Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Ala Tyr His Cys Gly Gln Asn Tyr Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length sequence of antibody constant region 

<400>  14

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  15
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length sequence of antibody constant region 

<400>  15

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly 
                325     


<210>  16
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 wild type Fc sequence

<400>  16

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  17
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  17

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Met Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Leu Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440         


<210>  18
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  18

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Met Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Leu Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440         


<210>  19
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  19

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Met Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440         


<210>  20
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Met Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440         


<210>  21
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Met Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Ile Thr Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440         


<210>  22
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Ile Thr Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440         


<210>  23
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Met Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Leu Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440         


<210>  24
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  24

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Gly Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Ala Tyr His Cys Gly Gln Asn Tyr Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  25
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  25

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Gly Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Ala Tyr His Cys Gly Gln Asn Tyr Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  26
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  26

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Gly Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg His Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr His Cys Gly Gln Asn Tyr Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  27
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  27

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Gly Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Ala Tyr His Cys Gly Gln Asn Tyr Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  28
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  28

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Met Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Leu Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440         


<210>  29
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  29

Ser Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Gly Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Ala Tyr His Cys Gly Gln Asn Tyr Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  30
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  30
gaggtgcagc tgctggagtc tggaggagga ctggtgcagc caggaggctc tctgaagctg     60

tcctgcaagg ccagcggcta cgctttcacc aactattggc tgggatggat gaagcagagg    120

ccaggacacg gactggagtg gatcggcgac ttttaccctc ggaccggcaa cacattctat    180

aacgagaact tcaagggcaa ggtgaccctg acagccgata agtccagcaa taccgcttac    240

atgcagctgt cttccctgac atccgaggac tccgccgtgt acctgtgcgc tagggctgga    300

accggattcg attattgggg ccagggcacc acactgacag tgagctctgc cagcaccaag    360

ggccccagcg tgttccctct ggctccttgt agccggtcca cctccgagtc cacagctgct    420

ctgggctgcc tcgtgaagga ctactttccc gaacccgtta ccgtgagctg gaatagcggc    480

gctttaacct ccggagtgca caccttcccc gctgtgctcc agtcctccgg tttatactct    540

ttatcctccg tggtgaccgt gccttcctcc agcctcggca ccaagaccta cacttgtaac    600

gtggaccaca agcccagcaa caccaaggtg gacaagaggg tggagtccaa gtacggacct    660

ccttgtcccc cttgccccgc ccccgaggcc gctggcggac cctccgtgtt cctcttcccc    720

cccaaaccca aggacacttt aatgatctcc cggacccccg aagtgacttg tgtggtggtg    780

gacgtgtccc aagaagaccc cgaggtgcag tttaactggt acgtggatgg cgtggaggtg    840

cacaacgcca agaccaagcc tagggaggaa cagttcaact ccacctaccg ggtggtgtcc    900

gtgctcaccg tgctgcatca agattggctg aacggcaagg agtacaagtg caaggtgagc    960

aacaagggac tgcccagctc catcgagaag accatcagca aggccaaagg ccagccccgg   1020

gaacctcaag tttatacact gccccccagc caagaagaga tgaccaagaa ccaagtttct   1080

ttaacttgtt tagtgaaggg cttctaccct agcgacatcg ctgtggagtg ggagtccaat   1140

ggccagcccg aaaacaatta taagaccacc ccccccgtgc tggactccga tggttctttt   1200

tttttatact ccaagctgac agtggacaag tctcgttggc aagaaggcaa cgtgttctct   1260

tgtagcgtga tgcacgaggc tttacacaac cactacaccc agaagtcttt atctctgtct   1320

ttaggc                                                              1326


<210>  31
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  31
gaggtgcagc tgctggagag cggcggcggc ctggtgcagc ccggcggcag cctgaagctg     60

agctgcaagg ccagcggcta cgccttcacc aactactggc tgggctggat gaagcagagg    120

cccggccacg gcctggagtg gatcggcggc ttctacccca ggaccggcaa caccttctac    180

aacgagaact tcaagggcaa ggtgaccctg accgccgaca agagcagcaa caccgcctac    240

atgcagctga gcagcctgac cagcgaggac agcgccgtgt acctgtgcgc cagggccggc    300

accggcttcg actactgggg ccagggcacc accctgaccg tgagcagcgc cagcaccaag    360

ggccccagcg tgttccctct ggctccttgt agccggtcca cctccgagtc cacagctgct    420

ctgggctgcc tcgtgaagga ctactttccc gaacccgtta ccgtgagctg gaatagcggc    480

gctttaacct ccggagtgca caccttcccc gctgtgctcc agtcctccgg tttatactct    540

ttatcctccg tggtgaccgt gccttcctcc agcctcggca ccaagaccta cacttgtaac    600

gtggaccaca agcccagcaa caccaaggtg gacaagaggg tggagtccaa gtacggacct    660

ccttgtcccc cttgccccgc ccccgaggcc gctggcggac cctccgtgtt cctcttcccc    720

cccaaaccca aggacacttt aatgatctcc cggacccccg aagtgacttg tgtggtggtg    780

gacgtgtccc aagaagaccc cgaggtgcag tttaactggt acgtggatgg cgtggaggtg    840

cacaacgcca agaccaagcc tagggaggaa cagttcaact ccacctaccg ggtggtgtcc    900

gtgctcaccg tgctgcatca agattggctg aacggcaagg agtacaagtg caaggtgagc    960

aacaagggac tgcccagctc catcgagaag accatcagca aggccaaagg ccagccccgg   1020

gaacctcaag tttatacact gccccccagc caagaagaga tgaccaagaa ccaagtttct   1080

ttaacttgtt tagtgaaggg cttctaccct agcgacatcg ctgtggagtg ggagtccaat   1140

ggccagcccg aaaacaatta taagaccacc ccccccgtgc tggactccga tggttctttt   1200

tttttatact ccaagctgac agtggacaag tctcgttggc aagaaggcaa cgtgttctct   1260

tgtagcgtga tgcacgaggc tttacacaac cactacaccc agaagtcttt atctctgtct   1320

ttaggc                                                              1326


<210>  32
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  32
gaggtgcagc tgctggagtc cggaggagga ctggtgcagc caggaggctc tctgaagctg     60

tcctgcaagg ccagcggcta cgctttcacc aactattggc tgggatggat gaagcagagg    120

ccaggacacg gactggagtg gatcggcgac ttttaccctc ggaccggcaa tacattctat    180

aacgagaact tcaagggcca ggtgacaatg tctgtggata agtccatcac cacagcctac    240

ctgcagtgga acagcctgaa ggcctctgac accgctatgt actattgtgc cagggctggc    300

acaggcttcg attattgggg ccagggcacc acactgaccg tgtccagcgc cagcaccaag    360

ggccccagcg tgttccctct ggctccttgt agccggtcca cctccgagtc cacagctgct    420

ctgggctgcc tcgtgaagga ctactttccc gaacccgtta ccgtgagctg gaatagcggc    480

gctttaacct ccggagtgca caccttcccc gctgtgctcc agtcctccgg tttatactct    540

ttatcctccg tggtgaccgt gccttcctcc agcctcggca ccaagaccta cacttgtaac    600

gtggaccaca agcccagcaa caccaaggtg gacaagaggg tggagtccaa gtacggacct    660

ccttgtcccc cttgccccgc ccccgaggcc gctggcggac cctccgtgtt cctcttcccc    720

cccaaaccca aggacacttt aatgatctcc cggacccccg aagtgacttg tgtggtggtg    780

gacgtgtccc aagaagaccc cgaggtgcag tttaactggt acgtggatgg cgtggaggtg    840

cacaacgcca agaccaagcc tagggaggaa cagttcaact ccacctaccg ggtggtgtcc    900

gtgctcaccg tgctgcatca agattggctg aacggcaagg agtacaagtg caaggtgagc    960

aacaagggac tgcccagctc catcgagaag accatcagca aggccaaagg ccagccccgg   1020

gaacctcaag tttatacact gccccccagc caagaagaga tgaccaagaa ccaagtttct   1080

ttaacttgtt tagtgaaggg cttctaccct agcgacatcg ctgtggagtg ggagtccaat   1140

ggccagcccg aaaacaatta taagaccacc ccccccgtgc tggactccga tggttctttt   1200

tttttatact ccaagctgac agtggacaag tctcgttggc aagaaggcaa cgtgttctct   1260

tgtagcgtga tgcacgaggc tttacacaac cactacaccc agaagtcttt atctctgtct   1320

ttaggc                                                              1326


<210>  33
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  33
caagtgcaac tggttcaatc tggagtggaa gttaagaagc ctggtgccag cgttaaagtg     60

agttgcaaag ccagcggata tgcctttacc aactattggc tgggctggat gaaacagagg    120

cctggccatg gtctggaatg gatcggagac ttttatccac gcaccggcaa cacattctat    180

aacgagaact tcaaaggtca ggtgaccatg tccgtggata agagcatcac taccgcttac    240

ctccagtgga acagtctgaa ggcttctgac accgccatgt actactgcgc tagggcaggc    300

accgggttcg actactgggg tcaagggacc accctcaccg tgagtagcgc cagcaccaag    360

ggccccagcg tgttccctct ggctccttgt agccggtcca cctccgagtc cacagctgct    420

ctgggctgcc tcgtgaagga ctactttccc gaacccgtta ccgtgagctg gaatagcggc    480

gctttaacct ccggagtgca caccttcccc gctgtgctcc agtcctccgg tttatactct    540

ttatcctccg tggtgaccgt gccttcctcc agcctcggca ccaagaccta cacttgtaac    600

gtggaccaca agcccagcaa caccaaggtg gacaagaggg tggagtccaa gtacggacct    660

ccttgtcccc cttgccccgc ccccgaggcc gctggcggac cctccgtgtt cctcttcccc    720

cccaaaccca aggacacttt aatgatctcc cggacccccg aagtgacttg tgtggtggtg    780

gacgtgtccc aagaagaccc cgaggtgcag tttaactggt acgtggatgg cgtggaggtg    840

cacaacgcca agaccaagcc tagggaggaa cagttcaact ccacctaccg ggtggtgtcc    900

gtgctcaccg tgctgcatca agattggctg aacggcaagg agtacaagtg caaggtgagc    960

aacaagggac tgcccagctc catcgagaag accatcagca aggccaaagg ccagccccgg   1020

gaacctcaag tttatacact gccccccagc caagaagaga tgaccaagaa ccaagtttct   1080

ttaacttgtt tagtgaaggg cttctaccct agcgacatcg ctgtggagtg ggagtccaat   1140

ggccagcccg aaaacaatta taagaccacc ccccccgtgc tggactccga tggttctttt   1200

tttttatact ccaagctgac agtggacaag tctcgttggc aagaaggcaa cgtgttctct   1260

tgtagcgtga tgcacgaggc tttacacaac cactacaccc agaagtcttt atctctgtct   1320

ttaggc                                                              1326


<210>  34
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  34
caagtgcagc tggttcaaag tggtgttgaa gttaagaagc ctggagctag tgtgaaggtg     60

tcctgtaagg cctccggcta tgcctttaca aactactggc tcgggtggat gaagcagcgc    120

ccaggacacg gtctggaatg gattggcgac ttttacccac ggacaggaaa tacattctat    180

aatgaaaact tcaaaggcaa agtgaccatc acagccgata agtccattac cactgcatac    240

atgcagctca gtagtctcaa agctagtgat acagcagtgt attactgcgc cagggccggc    300

accgggttcg actactgggg gcagggaacc accctcaccg tgagctctgc cagcaccaag    360

ggccccagcg tgttccctct ggctccttgt agccggtcca cctccgagtc cacagctgct    420

ctgggctgcc tcgtgaagga ctactttccc gaacccgtta ccgtgagctg gaatagcggc    480

gctttaacct ccggagtgca caccttcccc gctgtgctcc agtcctccgg tttatactct    540

ttatcctccg tggtgaccgt gccttcctcc agcctcggca ccaagaccta cacttgtaac    600

gtggaccaca agcccagcaa caccaaggtg gacaagaggg tggagtccaa gtacggacct    660

ccttgtcccc cttgccccgc ccccgaggcc gctggcggac cctccgtgtt cctcttcccc    720

cccaaaccca aggacacttt aatgatctcc cggacccccg aagtgacttg tgtggtggtg    780

gacgtgtccc aagaagaccc cgaggtgcag tttaactggt acgtggatgg cgtggaggtg    840

cacaacgcca agaccaagcc tagggaggaa cagttcaact ccacctaccg ggtggtgtcc    900

gtgctcaccg tgctgcatca agattggctg aacggcaagg agtacaagtg caaggtgagc    960

aacaagggac tgcccagctc catcgagaag accatcagca aggccaaagg ccagccccgg   1020

gaacctcaag tttatacact gccccccagc caagaagaga tgaccaagaa ccaagtttct   1080

ttaacttgtt tagtgaaggg cttctaccct agcgacatcg ctgtggagtg ggagtccaat   1140

ggccagcccg aaaacaatta taagaccacc ccccccgtgc tggactccga tggttctttt   1200

tttttatact ccaagctgac agtggacaag tctcgttggc aagaaggcaa cgtgttctct   1260

tgtagcgtga tgcacgaggc tttacacaac cactacaccc agaagtcttt atctctgtct   1320

ttaggc                                                              1326


<210>  35
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  35
caagtccaac tggttcaatc tggcgtggaa gtcaagaagc ccggagcctc cgtgaaggtg     60

agctgcaagg caagcggcta tgcattcact aactactggc tcggatgggt gaaacaacgg    120

ccaggacatg gcctggaatg gatcggcgac ttctacccta ggactggcaa cactttctat    180

aacgagaact ttaagggcaa ggtcaccatt acagctgata agagtatcac taccgcctac    240

atgcagctgt cttccctgaa agctagtgat acagccgttt attactgtgc tcgggctggc    300

acaggattcg attattgggg acagggtacc acactcacag tgtcctctgc cagcaccaag    360

ggccccagcg tgttccctct ggctccttgt agccggtcca cctccgagtc cacagctgct    420

ctgggctgcc tcgtgaagga ctactttccc gaacccgtta ccgtgagctg gaatagcggc    480

gctttaacct ccggagtgca caccttcccc gctgtgctcc agtcctccgg tttatactct    540

ttatcctccg tggtgaccgt gccttcctcc agcctcggca ccaagaccta cacttgtaac    600

gtggaccaca agcccagcaa caccaaggtg gacaagaggg tggagtccaa gtacggacct    660

ccttgtcccc cttgccccgc ccccgaggcc gctggcggac cctccgtgtt cctcttcccc    720

cccaaaccca aggacacttt aatgatctcc cggacccccg aagtgacttg tgtggtggtg    780

gacgtgtccc aagaagaccc cgaggtgcag tttaactggt acgtggatgg cgtggaggtg    840

cacaacgcca agaccaagcc tagggaggaa cagttcaact ccacctaccg ggtggtgtcc    900

gtgctcaccg tgctgcatca agattggctg aacggcaagg agtacaagtg caaggtgagc    960

aacaagggac tgcccagctc catcgagaag accatcagca aggccaaagg ccagccccgg   1020

gaacctcaag tttatacact gccccccagc caagaagaga tgaccaagaa ccaagtttct   1080

ttaacttgtt tagtgaaggg cttctaccct agcgacatcg ctgtggagtg ggagtccaat   1140

ggccagcccg aaaacaatta taagaccacc ccccccgtgc tggactccga tggttctttt   1200

tttttatact ccaagctgac agtggacaag tctcgttggc aagaaggcaa cgtgttctct   1260

tgtagcgtga tgcacgaggc tttacacaac cactacaccc agaagtcttt atctctgtct   1320

ttaggc                                                              1326


<210>  36
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  36
caagttcagc tggtgcaatc cggtgtcgag gtgaagaaac caggcgcaag cgtgaaagtc     60

tcctgcaagg cttctggcta tgccttcact aactactggc tcggctggat gaagcagagg    120

cccggacatg ggctggagtg gatcggagac ttctatccca gaactggaaa caccttttac    180

aacgagaatt tcaagggcaa ggtcaccctg actgccgaca aatcctctaa cacagcttac    240

atgcagctga gcagtctgac atccgaagac tctgcagttt acctgtgtgc tcgggcaggc    300

acaggcttcg attattgggg gcaagggacc actctgactg tgtcttccgc cagcaccaag    360

ggccccagcg tgttccctct ggctccttgt agccggtcca cctccgagtc cacagctgct    420

ctgggctgcc tcgtgaagga ctactttccc gaacccgtta ccgtgagctg gaatagcggc    480

gctttaacct ccggagtgca caccttcccc gctgtgctcc agtcctccgg tttatactct    540

ttatcctccg tggtgaccgt gccttcctcc agcctcggca ccaagaccta cacttgtaac    600

gtggaccaca agcccagcaa caccaaggtg gacaagaggg tggagtccaa gtacggacct    660

ccttgtcccc cttgccccgc ccccgaggcc gctggcggac cctccgtgtt cctcttcccc    720

cccaaaccca aggacacttt aatgatctcc cggacccccg aagtgacttg tgtggtggtg    780

gacgtgtccc aagaagaccc cgaggtgcag tttaactggt acgtggatgg cgtggaggtg    840

cacaacgcca agaccaagcc tagggaggaa cagttcaact ccacctaccg ggtggtgtcc    900

gtgctcaccg tgctgcatca agattggctg aacggcaagg agtacaagtg caaggtgagc    960

aacaagggac tgcccagctc catcgagaag accatcagca aggccaaagg ccagccccgg   1020

gaacctcaag tttatacact gccccccagc caagaagaga tgaccaagaa ccaagtttct   1080

ttaacttgtt tagtgaaggg cttctaccct agcgacatcg ctgtggagtg ggagtccaat   1140

ggccagcccg aaaacaatta taagaccacc ccccccgtgc tggactccga tggttctttt   1200

tttttatact ccaagctgac agtggacaag tctcgttggc aagaaggcaa cgtgttctct   1260

tgtagcgtga tgcacgaggc tttacacaac cactacaccc agaagtcttt atctctgtct   1320

ttaggc                                                              1326


<210>  37
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  37
gagatcgtga tgacccagtc cccagccaca ctgagcctgt ctgtgggaga gagggtgacc     60

ctgtcttgca aggcttccga gaacgtgggc ggctacgtga gctggtatca gcagaagccc    120

gaccagtctc ctaagctgct gatctacgga gcctccagca ggcacacagg agtgccagac    180

cggttcaccg gatccggaag cgagacagac ttcaccctga caatctcttc cgtgcaggct    240

gaggatctgg ccgcttatca ttgtggccag aattacatct atcccttcac ctttggcggc    300

ggcacaaagc tggagatcaa gcggaccgtg gctgccccct ccgtgttcat cttcccccct    360

tccgacgagc agctgaagtc cggcaccgct agcgtggtgt gtttactgaa caacttctac    420

cctcgtgagg ccaaggtgca gtggaaggtg gacaacgctt tacagtccgg caactcccaa    480

gaatccgtga ccgagcaaga ttccaaggac tccacctact ctttatcctc cactttaact    540

ttatccaagg ccgactacga gaagcacaag gtgtacgctt gtgaggtgac ccatcaaggt    600

ttatcctccc ccgtgaccaa gtccttcaat cgtggcgagt gc                       642


<210>  38
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  38
gagatcgtga tgacccagtc cccagccaca ctgagcctgt ctgtgggaga gagggtgacc     60

ctgtcttgca aggcttccga gaacgtgggc ggctacgtga gctggtatca gcagaagccc    120

gaccagtctc ctaagctgct gatctacgga gcctccagca gggctacagg agtgccagac    180

cggttcaccg gatccggaag cgagacagac ttcaccctga caatctcttc cgtgcaggcc    240

gaggatctgg ccgcttatca ctgtggccag aattacatct atcccttcac ctttggcggc    300

ggcacaaagc tggagatcaa gcggaccgtg gctgccccct ccgtgttcat cttcccccct    360

tccgacgagc agctgaagtc cggcaccgct agcgtggtgt gtttactgaa caacttctac    420

cctcgtgagg ccaaggtgca gtggaaggtg gacaacgctt tacagtccgg caactcccaa    480

gaatccgtga ccgagcaaga ttccaaggac tccacctact ctttatcctc cactttaact    540

ttatccaagg ccgactacga gaagcacaag gtgtacgctt gtgaggtgac ccatcaaggt    600

ttatcctccc ccgtgaccaa gtccttcaat cgtggcgagt gc                       642


<210>  39
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  39
gagatcgtga tgacccagag ccctgccaca ctgagcctgt ctgtgggcga gagggtgacc     60

ctgtcctgca aggcctccga gaacgtgggc ggctacgtgt cttggtatca gcagaagccc    120

gaccagtccc ctaagctgct gatctacgga gcctccagca ggcacaccgg agtgccagct    180

cggttctccg gaagcggatc tggcacagac tttaccctga caatctcttc cctggagcca    240

gaggatttcg ccgtgtatca ttgtggccag aattacatct atcccttcac ctttggcggc    300

ggcacaaagc tggagatcaa gcggaccgtg gctgccccct ccgtgttcat cttcccccct    360

tccgacgagc agctgaagtc cggcaccgct agcgtggtgt gtttactgaa caacttctac    420

cctcgtgagg ccaaggtgca gtggaaggtg gacaacgctt tacagtccgg caactcccaa    480

gaatccgtga ccgagcaaga ttccaaggac tccacctact ctttatcctc cactttaact    540

ttatccaagg ccgactacga gaagcacaag gtgtacgctt gtgaggtgac ccatcaaggt    600

ttatcctccc ccgtgaccaa gtccttcaat cgtggcgagt gc                       642


<210>  40
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  40
gaaattgtgc tgactcagtc tcctgctact ctgtccctgt ctcctggtga acgggccact     60

ctgagctgca aggccagtga aaatgtgggt ggctatgtta gctggtatca gcaaaagccc    120

gaccagtctc ccaaactgct gatctacggc gcttccagtc ggcacacagg cgtgccagat    180

cgctttactg ggagcggctc tgagactgac ttcacactga ccattagcag tgtccaggcc    240

gaagatctcg cagcctatca ttgcggccag aactacatct atccattcac cttcggtgga    300

ggaaccaaac tggaaatcaa gcggaccgtg gctgccccct ccgtgttcat cttcccccct    360

tccgacgagc agctgaagtc cggcaccgct agcgtggtgt gtttactgaa caacttctac    420

cctcgtgagg ccaaggtgca gtggaaggtg gacaacgctt tacagtccgg caactcccaa    480

gaatccgtga ccgagcaaga ttccaaggac tccacctact ctttatcctc cactttaact    540

ttatccaagg ccgactacga gaagcacaag gtgtacgctt gtgaggtgac ccatcaaggt    600

ttatcctccc ccgtgaccaa gtccttcaat cgtggcgagt gc                       642


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chainCDR1

<400>  41

Gly Tyr Ala Phe Thr Asn Tyr Trp Leu Gly 
1               5                   10  


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chainCDR2

<400>  42

Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe 
1               5                   10  


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chainCDR2

<400>  43

Gly Phe Tyr Pro Arg Thr Gly Asn Thr Phe 
1               5                   10  


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chainCDR3

<400>  44

Ala Arg Ala Gly Thr Gly Phe Asp Tyr 
1               5                   


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chainCDR1

<400>  45

Glu Asn Val Gly Gly Tyr Val Ser 
1               5               


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chainCDR2

<400>  46

Gly Ala Ser Ser Arg His Thr 
1               5           


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chainCDR2

<400>  47

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chainCDR3

<400>  48

Asn Tyr Ile Tyr Pro Phe Thr 
1               5           


<210>  49
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length sequence of antibody constant region 

<400>  49

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


