                         SEQUENCE LISTING

<110>  Trustees of Tufts College
       Kaplan, David L
       Stout, Andrew
       Yuen, John  Jr.
       Rubio, Natalie
 
<120>  ECTOPIC CELLULAR GROWTH FACTOR EXPRESSION FOR LOW-COST PRODUCTION
        OF CELL-CULTURED FOODS

<130>  166118.01116

<150>  63/112,682
<151>  2020-11-12

<160>  99    

<170>  PatentIn version 3.5

<210>  1
<211>  701
<212>  PRT
<213>  Bos taurus

<400>  1

Met Glu Ile Tyr Ser Pro Asp Met Ser Glu Gly Ala Ala Glu Arg Ser 
1               5                   10                  15      


Ser Ser Pro Ser Thr Gln Leu Ser Ala Asp Pro Ser Leu Asp Gly Leu 
            20                  25                  30          


Pro Ala Ala Glu Asp Met Pro Glu Thr Gln Thr Glu Asp Gly Arg Ser 
        35                  40                  45              


Pro Gly Leu Val Gly Leu Thr Leu Pro Cys Cys Val Cys Leu Glu Thr 
    50                  55                  60                  


Glu Arg Leu Arg Gly Cys Leu Asn Ser Glu Lys Ile Cys Ile Val Pro 
65                  70                  75                  80  


Ile Leu Ala Cys Leu Val Ser Leu Cys Leu Cys Ile Ala Gly Leu Lys 
                85                  90                  95      


Trp Val Phe Val Asp Lys Ile Phe Glu Tyr Asp Ser Pro Thr His Leu 
            100                 105                 110         


Asp Pro Gly Gly Leu Gly Gln Asp Pro Ile Ile Ser Leu Asp Pro Thr 
        115                 120                 125             


Ala Ala Ser Ala Ala Val Trp Val Ser Ala Lys Ala Tyr Thr Ser Pro 
    130                 135                 140                 


Val Ser Arg Ala Gln Ser Glu Thr Glu Val Arg Val Thr Val Gln Val 
145                 150                 155                 160 


Asp Asn Ala Leu Gly Ser Ser Glu Pro Ser Ala Val Pro Thr Pro Lys 
                165                 170                 175     


Asn Arg Ile Phe Ala Phe Ser Phe Arg Pro Ser Thr Ala Pro Ser Leu 
            180                 185                 190         


Pro Ser Pro Thr Arg Ser Pro Asp Val Arg Thr Pro Lys Ala Ala Thr 
        195                 200                 205             


Gln Pro Pro Ser Thr Glu Thr Asn Leu Gln Thr Ala Pro Lys Leu Ser 
    210                 215                 220                 


Thr Ser Thr Ser Thr Ala Gly Thr Ser His Leu Val Lys Cys Ala Glu 
225                 230                 235                 240 


Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys 
                245                 250                 255     


Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe 
            260                 265                 270         


Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys His 
        275                 280                 285             


Leu Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys Arg Val 
    290                 295                 300                 


Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met 
305                 310                 315                 320 


Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His 
                325                 330                 335     


Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Thr Met Met Asn 
            340                 345                 350         


Val Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln 
        355                 360                 365             


Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile 
    370                 375                 380                 


Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser 
385                 390                 395                 400 


Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp 
                405                 410                 415     


Ser Asn Gly His Thr Glu Ser Ile Ile Ser Glu Ser His Ser Val Ile 
            420                 425                 430         


Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly 
        435                 440                 445             


Pro Arg Gly Arg Leu Asn Gly Leu Gly Gly Pro Arg Glu Cys Asn Ser 
    450                 455                 460                 


Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro 
465                 470                 475                 480 


His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met Ser 
                485                 490                 495     


Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser Glu 
            500                 505                 510         


Met Ser Pro Pro Val Ser Ser Thr Thr Val Ser Met Pro Ser Met Ala 
        515                 520                 525             


Val Ser Pro Phe Val Glu Glu Glu Arg Pro Leu Leu Leu Val Thr Pro 
    530                 535                 540                 


Pro Arg Leu Arg Glu Lys Tyr Asp His His Ala Gln Gln Phe Asn Ser 
545                 550                 555                 560 


Phe His Cys Asn Pro Ala His Glu Ser Asn Ser Leu Pro Pro Ser Pro 
                565                 570                 575     


Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu Tyr Glu 
            580                 585                 590         


Pro Ala Gln Glu Pro Val Lys Lys Leu Thr Asn Ser Ser Arg Arg Ala 
        595                 600                 605             


Lys Arg Thr Lys Pro Asn Gly His Ile Ala His Arg Leu Glu Met Asp 
    610                 615                 620                 


Asn Asn Thr Gly Ala Asp Ser Ser Asn Ser Glu Ser Glu Thr Glu Asp 
625                 630                 635                 640 


Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Ala Ile Gln Asn Pro Leu 
                645                 650                 655     


Ala Ala Ser Leu Glu Ala Ala Pro Ala Phe Arg Leu Val Asp Ser Arg 
            660                 665                 670         


Thr Asn Pro Thr Gly Arg Phe Ser Pro Gln Glu Glu Leu Gln Ala Arg 
        675                 680                 685             


Leu Ser Gly Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
    690                 695                 700     


<210>  2
<211>  649
<212>  PRT
<213>  Oreochromis niloticus

<400>  2

Met Glu Glu Val Ser Ala Gly Pro Ala Pro Pro Phe Gly Ser Val Ser 
1               5                   10                  15      


Pro Thr Gly Ser Thr Val Asp Thr Arg Gln Val Pro Glu Glu Lys Pro 
            20                  25                  30          


Glu Glu Thr Glu Ala Ala Gly Glu Ser Gly Glu Glu Ala Ile Glu Gly 
        35                  40                  45              


Thr Ala Glu Gly Gly Gly Ala Gly Asp Asp Gly Glu His Val Gly Ala 
    50                  55                  60                  


Phe Gly Ile Val Thr Leu Pro Glu Ala Cys Cys Val Cys Ile Glu Met 
65                  70                  75                  80  


Glu Gln Ile Asn Asn Cys Leu His Ser Glu Lys Ile Cys Ile Leu Pro 
                85                  90                  95      


Ile Leu Ala Cys Leu Leu Ser Leu Ala Leu Cys Thr Ala Gly Leu Lys 
            100                 105                 110         


Trp Val Phe Val Asp Lys Ile Phe Glu Tyr Glu Pro Pro Ser His Leu 
        115                 120                 125             


Asp Pro Lys Pro Ile Gly Gln Asp Pro Ile Ile Ile Pro Val Glu Pro 
    130                 135                 140                 


Thr Leu Gly Ile Thr Val Ser Phe Pro His Thr Thr Pro Ser Asn Asn 
145                 150                 155                 160 


Ser Leu Thr Thr Thr Phe Thr Leu Thr Pro Glu His Pro Glu Val Ser 
                165                 170                 175     


Val Lys Asp Lys Ser Thr Gln His His His Gln Thr Ile Cys Lys Cys 
            180                 185                 190         


Leu Phe Pro Ala Thr Ile Ser Thr Ser Thr Thr Ala Lys Thr Ser Ser 
        195                 200                 205             


His Val Thr Arg Cys Ser Asp Ser Gln Arg Asn Tyr Cys Val Asn Gly 
    210                 215                 220                 


Gly Glu Cys Phe Thr Leu Glu Ile Ile Pro Gly Ser Thr Lys Cys Pro 
225                 230                 235                 240 


Val Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe 
                245                 250                 255     


Tyr Lys Trp Leu Ser Phe Phe Ser Glu Ala Glu Glu Leu Tyr Gln Lys 
            260                 265                 270         


Arg Ile Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly 
        275                 280                 285             


Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys 
    290                 295                 300                 


Leu Arg Asp Arg Leu Arg Gln Ser Leu Arg Asn Lys Arg Lys Asn Thr 
305                 310                 315                 320 


Ser Thr Gly Ile Asp Ser Asn Val Ala Lys Ser Thr Thr Gly Arg Pro 
                325                 330                 335     


Asn Ser Asn Leu Pro Leu Gln Asp Leu Gln Leu Ile Gly Val Cys Cys 
            340                 345                 350         


Tyr Phe Val Ser Val Val Ser His Thr Ala Glu Lys Glu Thr Glu Thr 
        355                 360                 365             


Asn Phe Ser Thr Ser Lys Tyr Thr Leu Ser Val His Asp Pro Thr Thr 
    370                 375                 380                 


Leu Thr Asn Ile Ser Ser Gln Ser Trp Ser Asn Asp Trp Ser Asn Ser 
385                 390                 395                 400 


Val Gln Ser Asp Thr Glu Ser Val Ser Val Met Ser Leu Ala Glu Asn 
                405                 410                 415     


Ser Gln Arg Ala Thr Gln Gly Ala Arg Gly Arg Leu Asn Ala Thr Gly 
            420                 425                 430         


Gly Thr Ser Asp Leu Ser Ala His Ser Lys Lys Phe Val Pro Val Met 
        435                 440                 445             


Thr Thr Leu Ile Gln Leu Thr Ser Glu Ser Gln Asn Ser Leu Ala Thr 
    450                 455                 460                 


Pro Gly Ser Pro Pro Ser Glu Ile Ser Ala Pro Ile Ser Ser Leu Ala 
465                 470                 475                 480 


Ile Ser Val Pro Ser Val Thr Leu Ser Pro Ser Gly Glu Glu Glu Arg 
                485                 490                 495     


Pro Leu Leu His Gln Leu His Lys Ser Ser Ser Arg Asp Val Gln Lys 
            500                 505                 510         


Arg Thr Ser Ser His Tyr Asn His Gly His Val Ala Asp Ser Leu Pro 
        515                 520                 525             


Ser Ser Pro Leu Phe Thr Met Glu Asn Ala Asp Tyr Gln Thr Ile Gln 
    530                 535                 540                 


Asp Thr Arg Ala Ala Ser Cys Met Phe Ser Thr Ala Pro Val Lys Leu 
545                 550                 555                 560 


Ile Asn Thr Asn Asn Asn Val Ser Asp Cys Ser Asn Lys Ser Val Thr 
                565                 570                 575     


Asp His Val Val Asp Tyr Leu Arg Leu Asn Gly Asp Ser Ile Leu Val 
            580                 585                 590         


Ser Asp Thr Glu Glu Pro Arg Gly Glu His Ile Pro Phe Leu Ser Ala 
        595                 600                 605             


Asp Arg Asn Thr Ala Leu Leu Leu Arg Ala Ile Asp Ser Ser Arg Thr 
    610                 615                 620                 


Asn Pro Ala Ser Pro Asn Asp Asp Leu Pro Val Lys Ser Ser Ser Leu 
625                 630                 635                 640 


Ile Asn Gln Gln Asp Ser Ile Ala Ala 
                645                 


<210>  3
<211>  105
<212>  PRT
<213>  Bos taurus

<400>  3

Met Ala Leu Trp Thr Arg Leu Arg Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Pro Pro Pro Pro Ala Arg Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Ala Arg Arg Glu Val Glu Gly Pro Gln Val Gly 
    50                  55                  60                  


Ala Leu Glu Leu Ala Gly Gly Pro Gly Ala Gly Gly Leu Glu Gly Pro 
65                  70                  75                  80  


Pro Gln Lys Arg Gly Ile Val Glu Gln Cys Cys Ala Ser Val Cys Ser 
                85                  90                  95      


Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105 


<210>  4
<211>  113
<212>  PRT
<213>  Oreochromis niloticus

<400>  4

Met Ala Ala Leu Trp Leu Gln Ala Phe Ser Leu Leu Val Leu Met Met 
1               5                   10                  15      


Val Ser Trp Pro Gly Ser Gln Ala Val Gly Gly Pro Gln His Leu Cys 
            20                  25                  30          


Gly Ser His Leu Val Asp Ala Leu Tyr Leu Val Cys Gly Asp Arg Gly 
        35                  40                  45              


Phe Phe Tyr Asn Pro Arg Arg Asp Val Asp Pro Leu Leu Gly Phe Leu 
    50                  55                  60                  


Pro Pro Lys Ala Gly Gly Ala Val Val Gln Gly Gly Glu Asn Glu Val 
65                  70                  75                  80  


Thr Phe Lys Asp Gln Met Glu Met Met Val Lys Arg Gly Ile Val Glu 
                85                  90                  95      


Glu Cys Cys His Lys Pro Cys Thr Ile Phe Asp Leu Gln Asn Tyr Cys 
            100                 105                 110         


Asn 
    


<210>  5
<211>  704
<212>  PRT
<213>  Bos taurus

<400>  5

Met Arg Pro Ala Val Arg Ala Leu Leu Ala Cys Ala Val Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Asp Pro Glu Arg Thr Val Arg Trp Cys Thr Ile Ser Thr 
            20                  25                  30          


His Glu Ala Asn Lys Cys Ala Ser Phe Arg Glu Asn Val Leu Arg Ile 
        35                  40                  45              


Leu Glu Ser Gly Pro Phe Val Ser Cys Val Lys Lys Thr Ser His Met 
    50                  55                  60                  


Asp Cys Ile Lys Ala Ile Ser Asn Asn Glu Ala Asp Ala Val Thr Leu 
65                  70                  75                  80  


Asp Gly Gly Leu Val Tyr Glu Ala Gly Leu Lys Pro Asn Asn Leu Lys 
                85                  90                  95      


Pro Val Val Ala Glu Phe His Gly Thr Lys Asp Asn Pro Gln Thr His 
            100                 105                 110         


Tyr Tyr Ala Val Ala Val Val Lys Lys Asp Thr Asp Phe Lys Leu Asn 
        115                 120                 125             


Glu Leu Arg Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser Ala 
    130                 135                 140                 


Gly Trp Asn Ile Pro Met Ala Lys Leu Tyr Lys Glu Leu Pro Asp Pro 
145                 150                 155                 160 


Gln Glu Ser Ile Gln Arg Ala Ala Ala Asn Phe Phe Ser Ala Ser Cys 
                165                 170                 175     


Val Pro Cys Ala Asp Gln Ser Ser Phe Pro Lys Leu Cys Gln Leu Cys 
            180                 185                 190         


Ala Gly Lys Gly Thr Asp Lys Cys Ala Cys Ser Asn His Glu Pro Tyr 
        195                 200                 205             


Phe Gly Tyr Ser Gly Ala Phe Lys Cys Leu Met Glu Gly Ala Gly Asp 
    210                 215                 220                 


Val Ala Phe Val Lys His Ser Thr Val Phe Asp Asn Leu Pro Asn Pro 
225                 230                 235                 240 


Glu Asp Arg Lys Asn Tyr Glu Leu Leu Cys Gly Asp Asn Thr Arg Lys 
                245                 250                 255     


Ser Val Asp Asp Tyr Gln Glu Cys Tyr Leu Ala Met Val Pro Ser His 
            260                 265                 270         


Ala Val Val Ala Arg Thr Val Gly Gly Lys Glu Asp Val Ile Trp Glu 
        275                 280                 285             


Leu Leu Asn His Ala Gln Glu His Phe Gly Lys Asp Lys Pro Asp Asn 
    290                 295                 300                 


Phe Gln Leu Phe Gln Ser Pro His Gly Lys Asp Leu Leu Phe Lys Asp 
305                 310                 315                 320 


Ser Ala Asp Gly Phe Leu Lys Ile Pro Ser Lys Met Asp Phe Glu Leu 
                325                 330                 335     


Tyr Leu Gly Tyr Glu Tyr Val Thr Ala Leu Gln Asn Leu Arg Glu Ser 
            340                 345                 350         


Lys Pro Pro Asp Ser Ser Lys Asp Glu Cys Met Val Lys Trp Cys Ala 
        355                 360                 365             


Ile Gly His Gln Glu Arg Thr Lys Cys Asp Arg Trp Ser Gly Phe Ser 
    370                 375                 380                 


Gly Gly Ala Ile Glu Cys Glu Thr Ala Glu Asn Thr Glu Glu Cys Ile 
385                 390                 395                 400 


Ala Lys Ile Met Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly 
                405                 410                 415     


Tyr Leu Tyr Ile Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu 
            420                 425                 430         


Asn Tyr Lys Thr Glu Gly Glu Ser Cys Lys Asn Thr Pro Glu Lys Gly 
        435                 440                 445             


Tyr Leu Ala Val Ala Val Val Lys Thr Ser Asp Ala Asn Ile Asn Trp 
    450                 455                 460                 


Asn Asn Leu Lys Asp Lys Lys Ser Cys His Thr Ala Val Asp Arg Thr 
465                 470                 475                 480 


Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Tyr Ser Lys Ile Asn Asn 
                485                 490                 495     


Cys Lys Phe Asp Glu Phe Phe Ser Ala Gly Cys Ala Pro Gly Ser Pro 
            500                 505                 510         


Arg Asn Ser Ser Leu Cys Ala Leu Cys Ile Gly Ser Glu Lys Gly Thr 
        515                 520                 525             


Gly Lys Glu Cys Val Pro Asn Ser Asn Glu Arg Tyr Tyr Gly Tyr Thr 
    530                 535                 540                 


Gly Ala Phe Arg Cys Leu Val Glu Lys Gly Asp Val Ala Phe Val Lys 
545                 550                 555                 560 


Asp Gln Thr Val Ile Gln Asn Thr Asp Gly Asn Asn Asn Glu Ala Trp 
                565                 570                 575     


Ala Lys Asn Leu Lys Lys Glu Asn Phe Glu Val Leu Cys Lys Asp Gly 
            580                 585                 590         


Thr Arg Lys Pro Val Thr Asp Ala Glu Asn Cys His Leu Ala Arg Gly 
        595                 600                 605             


Pro Asn His Ala Val Val Ser Arg Lys Asp Lys Ala Thr Cys Val Glu 
    610                 615                 620                 


Lys Ile Leu Asn Lys Gln Gln Asp Asp Phe Gly Lys Ser Val Thr Asp 
625                 630                 635                 640 


Cys Thr Ser Asn Phe Cys Leu Phe Gln Ser Asn Ser Lys Asp Leu Leu 
                645                 650                 655     


Phe Arg Asp Asp Thr Lys Cys Leu Ala Ser Ile Ala Lys Lys Thr Tyr 
            660                 665                 670         


Asp Ser Tyr Leu Gly Asp Asp Tyr Val Arg Ala Met Thr Asn Leu Arg 
        675                 680                 685             


Gln Cys Ser Thr Ser Lys Leu Leu Glu Ala Cys Thr Phe His Lys Pro 
    690                 695                 700                 


<210>  6
<211>  718
<212>  PRT
<213>  Oreochromis niloticus

<400>  6

Val Ala Met Trp Arg Thr Val Gly Thr Leu Leu Leu Ile Leu His Thr 
1               5                   10                  15      


Val Phe Gly Gln Ser Thr Ile Lys Trp Cys Thr Ile Ser Gln Asn Glu 
            20                  25                  30          


Gln Arg Lys Cys Gln Ala Met Ser Gln Ala Phe Ser Thr Ala Ser Ile 
        35                  40                  45              


Arg Pro Ser Leu Ser Cys Val Asn Ala Ala Ser Val Glu Asp Cys Gly 
    50                  55                  60                  


Gln Lys Leu Gln Arg Lys Glu Ala Asp Ala Leu Ser Met Ser Ala Lys 
65                  70                  75                  80  


Asp Ile Tyr Asn Leu Gly Lys Thr Val Ser Leu Lys Met Ala Gly Ser 
                85                  90                  95      


Glu Ser Gln Ala Gly Ser Val Thr Thr Tyr Tyr Ala Val Ala Val Val 
            100                 105                 110         


Lys Lys Glu Asn Ser Gly Ile Asn Ile Asn Asn Leu Ala Gly Lys Lys 
        115                 120                 125             


Ser Cys His Thr Gly Ile Gly Arg Thr Val Gly Trp Asn Met Pro Ile 
    130                 135                 140                 


Gly Tyr Leu Ile Asp Gln Gly Tyr Met Ser Val Met Gly Cys Asn Ile 
145                 150                 155                 160 


Pro Gln Gly Val Ala Asn Phe Phe Ser Ala Ser Cys Ile Pro Gly Ala 
                165                 170                 175     


Thr Gln Gly Glu Pro Gln Ser Leu Cys Gln Leu Cys Arg Gly Asp Glu 
            180                 185                 190         


Ser Gly Gln His Lys Cys Glu Met Ser Ser Asn Glu Arg Tyr Tyr Ser 
        195                 200                 205             


Tyr Glu Gly Ala Phe Arg Cys Leu Ala Asp Gly Ala Gly Glu Val Ala 
    210                 215                 220                 


Phe Thr Lys Asp Thr Thr Val Glu Glu Asn Thr Asp Gly Arg Gly Pro 
225                 230                 235                 240 


Thr Trp Ala Lys Asp Leu Lys Ser Ser Asp Tyr Glu Leu Leu Cys Pro 
                245                 250                 255     


Asp Gly Thr Arg Ala Pro Val Thr Gln Trp Ser Arg Cys Asn Leu Val 
            260                 265                 270         


Pro Val Pro Ser Arg Gly Val Val Val Arg Asn Asp Ile Ser Pro Ser 
        275                 280                 285             


Val Val Phe Asn Met Leu Met Glu Gly Leu Glu Lys Ser Asn Phe Pro 
    290                 295                 300                 


Met Phe Ser Ser Ala Gly Tyr Gly Asp Gly Thr Val Leu Phe Ser Asn 
305                 310                 315                 320 


Leu Thr Thr Thr Phe Lys Ala Ala Asn Ser Asp Glu Pro Lys Lys Trp 
                325                 330                 335     


Met Gly Glu Arg Tyr His Asn Ala Leu Lys Ala Met Asp Cys Asp Pro 
            340                 345                 350         


Lys Asp Ile Pro Asn Ala Leu Arg Trp Cys Val Ile Ser Ser Gly Glu 
        355                 360                 365             


Gln Gln Lys Cys Ala Asp Met Ser Val Ala Phe Gln Ser Lys Gly Leu 
    370                 375                 380                 


Thr Pro Asn Ile Asn Cys Val Tyr Gly Asp Ser Val Thr His Cys Met 
385                 390                 395                 400 


Lys Lys Ile Lys Asp Asn Asp Ala Asp Ala Ile Thr Leu Asp Gly Gly 
                405                 410                 415     


Tyr Ile Tyr Thr Ala Gly Lys Asp Tyr Gly Leu Val Pro Ala Thr Gly 
            420                 425                 430         


Glu Ser Tyr Thr Asp Asp His Asp Gly Ser Ser Tyr Tyr Ala Val Ala 
        435                 440                 445             


Val Val Lys Lys Ser Ser Phe Asp Ile Arg Asn Leu Asp Asp Leu Arg 
    450                 455                 460                 


Gly Arg Arg Ser Cys His Thr Gly Tyr Gly Arg Thr Ala Gly Trp Asn 
465                 470                 475                 480 


Ile Pro Val Ala Val Leu Met Glu Arg Gly Leu Ile Ser Pro Gln Gln 
                485                 490                 495     


Cys Gln Ile Pro Gln Ala Val Gly Asp Phe Phe Glu Lys Cys Cys Val 
            500                 505                 510         


Pro Gly Ala Asn Gln Ala Gly Phe Pro Ser Asn Leu Cys Glu Leu Cys 
        515                 520                 525             


Val Gly Asp Glu Ser Gly Gln Asn Lys Cys Glu Lys Gly Lys Asp Leu 
    530                 535                 540                 


Tyr Asp Gly Tyr Asp Gly Ala Phe Arg Cys Val Ala Lys Gly Glu Gly 
545                 550                 555                 560 


Asp Val Ala Phe Val Lys His Ser Thr Val Leu Glu Asn Thr Ala Gly 
                565                 570                 575     


Lys Thr Ser Leu Pro Pro Ser Asp Phe Gln Leu Leu Cys Gln Ser Gly 
            580                 585                 590         


Gly Lys Ala Glu Ala Thr His Tyr Lys Tyr Cys Asn Leu Gly Arg Val 
        595                 600                 605             


Pro Ser His Ala Val Met Val Arg Pro Asp Met Asn Ile His Ala Ile 
    610                 615                 620                 


Tyr Gly Leu Leu Asp Gln Ala Gln Thr Tyr Phe Gly Ser Asp Thr Gly 
625                 630                 635                 640 


Thr Ala Phe Lys Met Phe Asp Ser Gln Val Tyr Lys Gly Thr Asp Leu 
                645                 650                 655     


Ile Phe Lys Asp Ser Thr Val Arg Leu Val Gly Val Ala Asp Arg Lys 
            660                 665                 670         


Thr Tyr Gln Glu Trp Leu Gly Gln Ile Tyr Leu Asp Ser Leu Val Asp 
        675                 680                 685             


Leu Glu Cys Ser Ser Ser Asn Ala Val Ala Ser Ser Val Trp Leu Leu 
    690                 695                 700                 


Pro Thr Ala Leu Phe Ser Phe Met Leu Thr Asn Tyr Trp Met 
705                 710                 715             


<210>  7
<211>  465
<212>  PRT
<213>  Bos taurus

<400>  7

Met Ala Glu Gly Glu Thr Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      


Asn Leu Pro Leu Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly Tyr Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Lys Asp Arg Ser Asp Gln His Ile Met Ala Glu Gly Glu Thr Thr 
    50                  55                  60                  


Thr Phe Thr Ala Leu Thr Glu Lys Phe Asn Leu Pro Leu Gly Asn Tyr 
65                  70                  75                  80  


Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly Tyr Phe Leu Arg 
                85                  90                  95      


Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Lys Asp Arg Ser Asp Gln 
            100                 105                 110         


His Ile Gln Leu Gln Leu Cys Ala Glu Ser Ile Gly Glu Val Tyr Ile 
        115                 120                 125             


Lys Ser Thr Glu Thr Gly Gln Phe Leu Ala Met Asp Thr Asp Gly Leu 
    130                 135                 140                 


Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg 
145                 150                 155                 160 


Leu Glu Glu Asn His Tyr Asn Thr Tyr Ile Ser Lys Lys His Ala Glu 
                165                 170                 175     


Lys His Trp Phe Val Gly Leu Lys Lys Asn Gly Arg Ser Lys Leu Gly 
            180                 185                 190         


Pro Arg Thr His Phe Gly Gln Lys Ala Ile Leu Phe Leu Pro Leu Pro 
        195                 200                 205             


Val Ser Ser Asp Met Ala Glu Gly Glu Thr Thr Thr Phe Thr Ala Leu 
    210                 215                 220                 


Thr Glu Lys Phe Asn Leu Pro Leu Gly Asn Tyr Lys Lys Pro Lys Leu 
225                 230                 235                 240 


Leu Tyr Cys Ser Asn Gly Gly Tyr Phe Leu Arg Ile Leu Pro Asp Gly 
                245                 250                 255     


Thr Val Asp Gly Thr Lys Asp Arg Ser Asp Gln His Ile Gln Leu Gln 
            260                 265                 270         


Leu Cys Ala Glu Ser Ile Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr 
        275                 280                 285             


Gly Gln Phe Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln 
    290                 295                 300                 


Thr Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His 
305                 310                 315                 320 


Tyr Asn Thr Tyr Ile Ser Lys Lys His Ala Glu Lys His Trp Phe Val 
                325                 330                 335     


Gly Leu Lys Lys Asn Gly Arg Ser Lys Leu Gly Pro Arg Thr His Phe 
            340                 345                 350         


Gly Gln Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp Gln 
        355                 360                 365             


Leu Gln Leu Cys Ala Glu Ser Ile Gly Glu Val Tyr Ile Lys Ser Thr 
    370                 375                 380                 


Glu Thr Gly Gln Phe Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly 
385                 390                 395                 400 


Ser Gln Thr Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu 
                405                 410                 415     


Asn His Tyr Asn Thr Tyr Ile Ser Lys Lys His Ala Glu Lys His Trp 
            420                 425                 430         


Phe Val Gly Leu Lys Lys Asn Gly Arg Ser Lys Leu Gly Pro Arg Thr 
        435                 440                 445             


His Phe Gly Gln Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser 
    450                 455                 460                 


Asp 
465 


<210>  8
<211>  207
<212>  PRT
<213>  Oreochromis niloticus

<400>  8

Met Arg Pro Ile Pro Ser Arg Leu Ser Cys Val Phe Leu His Leu Phe 
1               5                   10                  15      


Ala Leu Phe Tyr Tyr Ala Gln Val Thr Asn Gln Ser Pro Pro Asn Phe 
            20                  25                  30          


Thr Gln His Val Ser Glu Gln Ser Lys Val Thr Asp Arg Thr Ser Arg 
        35                  40                  45              


Arg Leu Ile Arg Ile Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys His 
    50                  55                  60                  


Val Gln Val Leu Pro Asn Lys Lys Ile Asn Ala Met Ala Glu Asp Gly 
65                  70                  75                  80  


Asp Val His Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg 
                85                  90                  95      


Val Arg Ile Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met Asn Lys 
            100                 105                 110         


Arg Gly Lys Leu Ile Gly Lys Lys Asn Gly Gln Gly Arg Asp Cys Ile 
        115                 120                 125             


Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Lys Asn Val 
    130                 135                 140                 


Arg Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg Gln Gly Arg Pro Arg 
145                 150                 155                 160 


Lys Gly Ser Arg Thr Arg Gln His Gln Arg Glu Val His Phe Met Lys 
                165                 170                 175     


Arg Leu Pro Lys Gly His Gln Pro Thr His Pro Ser His His Gln Pro 
            180                 185                 190         


Phe Asp Phe Ile His Tyr Pro Phe Ser Gln Arg Thr Lys Arg Thr 
        195                 200                 205         


<210>  9
<211>  832
<212>  PRT
<213>  Bos taurus

<400>  9

Met Trp Ser Arg Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Lys Pro Ala Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Leu Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Asp Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Arg Gly Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys His Ser Gly Ile Asn Ser Ser Asp 
305                 310                 315                 320 


Ala Glu Val Leu Thr Leu Phe Asn Val Thr Glu Ala Gln Ser Gly Glu 
                325                 330                 335     


Tyr Val Cys Lys Val Ser Asn Tyr Ile Gly Glu Ala Asn Gln Ser Ala 
            340                 345                 350         


Trp Leu Thr Val Thr Arg Pro Val Ala Lys Ala Leu Glu Glu Arg Pro 
        355                 360                 365             


Ala Val Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr 
    370                 375                 380                 


Gly Ala Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Ile Tyr Lys 
385                 390                 395                 400 


Met Lys Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val 
                405                 410                 415     


His Lys Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser 
            420                 425                 430         


Ala Asp Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro 
        435                 440                 445             


Ser Arg Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu 
    450                 455                 460                 


Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu 
465                 470                 475                 480 


Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu 
                485                 490                 495     


Ala Glu Ala Ile Gly Leu Asp Lys Asp Arg Pro Asn Arg Val Thr Lys 
            500                 505                 510         


Val Ala Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser 
        515                 520                 525             


Asp Leu Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys 
    530                 535                 540                 


Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr 
545                 550                 555                 560 


Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln 
                565                 570                 575     


Ala Arg Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His His 
            580                 585                 590         


Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln 
        595                 600                 605             


Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg 
    610                 615                 620                 


Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys 
625                 630                 635                 640 


Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr 
                645                 650                 655     


Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu 
            660                 665                 670         


Ala Leu Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe 
        675                 680                 685             


Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro 
    690                 695                 700                 


Gly Val Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg 
705                 710                 715                 720 


Met Asp Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg 
                725                 730                 735     


Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu 
            740                 745                 750         


Val Glu Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr 
        755                 760                 765             


Leu Asp Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp 
    770                 775                 780                 


Thr Arg Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His 
785                 790                 795                 800 


Glu Pro Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu 
                805                 810                 815     


Ala Asn Gly Gly Leu Lys Arg Arg Asp Tyr Lys Asp Asp Asp Asp Lys 
            820                 825                 830         


<210>  10
<211>  837
<212>  PRT
<213>  Oreochromis niloticus

<400>  10

Met Ser Gln Thr Pro Glu Trp Ser Ser Arg Arg Thr Lys Ala Asn Ser 
1               5                   10                  15      


Arg Ser Ser Val Ser Arg Met Leu Met Arg Pro Ser Ile Leu Leu Phe 
            20                  25                  30          


Leu Ala Leu Phe Ala Gln Val Leu Arg Thr Gln Cys Arg Pro Ala Asn 
        35                  40                  45              


Ala Asp Glu Val Ser Val Glu Thr Gln Ala Glu Leu Tyr Thr Leu Ser 
    50                  55                  60                  


Ile Gly Asp Arg Leu Asp Leu Ser Cys Cys Ala Lys Asp Tyr Leu His 
65                  70                  75                  80  


Ala Val Asn Trp Thr Lys Asp His Val Ala Val Val Asp Gly Glu His 
                85                  90                  95      


Thr Arg Ile Arg Asn Gly Gln Leu Glu Ile Glu Ser Val Glu Leu Thr 
            100                 105                 110         


Asp Ser Gly Leu Tyr Thr Cys Thr Thr Phe Gly Asn His Ser Ile Phe 
        115                 120                 125             


Phe Asn Val Thr Val His Ile Ser Ala Ser Ser Glu Asp Asp Asp Asp 
    130                 135                 140                 


Gly Glu Glu Ser Ser Ser Glu Glu Asn Lys Leu Leu Gly Ser Gln Lys 
145                 150                 155                 160 


Leu Met Pro Met Ala Pro Gln Trp Ala His Pro Glu Lys Met Glu Lys 
                165                 170                 175     


Lys Leu His Ala Val Pro Ala Ser Lys Thr Val Lys Phe Lys Cys Gln 
            180                 185                 190         


Ala Ser Gly Asn Pro Thr Pro Thr Leu Lys Trp Tyr Lys Asn Gly Lys 
        195                 200                 205             


Glu Phe Lys Arg Asp His Arg Ile Gly Gly Phe Lys Val Arg Asp His 
    210                 215                 220                 


Met Trp Thr Ile Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn 
225                 230                 235                 240 


Tyr Thr Cys Val Val Glu Asn Lys Tyr Gly Ser Ile Asn His Thr Tyr 
                245                 250                 255     


Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala 
            260                 265                 270         


Gly Leu Pro Ala Asn Arg Thr Val Val Val Gly Ser Asp Val Glu Phe 
        275                 280                 285             


Glu Cys Lys Val Phe Ser Asp Pro Gln Pro His Ile Gln Trp Leu Lys 
    290                 295                 300                 


His Ile Glu Val Asn Gly Asn Arg Thr Gly Pro Asp Gly Leu Pro Tyr 
305                 310                 315                 320 


Val Arg Val Leu Lys His Ser Gly Val Asn Ser Ser Asp Ala Gln Val 
                325                 330                 335     


Leu Thr Leu Tyr Asn Val Thr Glu Glu Glu Ser Gly Glu Tyr Ile Cys 
            340                 345                 350         


Lys Val Ser Asn Tyr Ile Gly Glu Val Ser Gln Ser Ala Trp Leu Thr 
        355                 360                 365             


Val Ile Arg Tyr Glu Pro Thr Ala Pro Pro His Tyr Ser Pro Ala Ser 
    370                 375                 380                 


His Thr Tyr Leu Glu Val Val Ile Tyr Cys Val Gly Phe Phe Phe Ile 
385                 390                 395                 400 


Phe Ala Ile Met Ile Ala Ile Ala Ile Ile Val Lys Ile Arg Thr Thr 
                405                 410                 415     


Ser Ser Lys Lys Ser Asp Phe Asn Ser Gln Leu Ala Val His Lys Leu 
            420                 425                 430         


Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Val Asp Ser 
        435                 440                 445             


Ser Ser Ser Ile His Ser Gly Val Met Leu Val Arg Pro Ser Arg Leu 
    450                 455                 460                 


Ser Ser Ser Gly Ser Pro Met Leu Ser Gly Val Ser Glu Cys Glu Leu 
465                 470                 475                 480 


Pro Gln Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly 
                485                 490                 495     


Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Gly Glu Ala 
            500                 505                 510         


Val Gly Leu Asp Lys Glu Lys Pro Asn Arg Val Thr Lys Val Ala Val 
        515                 520                 525             


Lys Met Leu Lys Ala Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile 
    530                 535                 540                 


Ser Glu Met Glu Met Met Lys Ile Ile Gly Lys His Lys Asn Ile Ile 
545                 550                 555                 560 


Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val 
                565                 570                 575     


Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg 
            580                 585                 590         


Pro Pro Gly Met Glu Tyr Cys Ser Asn Pro Asp Gln Val Pro Val Glu 
        595                 600                 605             


Asn Val Ser Ile Lys Asp Leu Val Ser Phe Ala Tyr Gln Val Ala Arg 
    610                 615                 620                 


Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala 
625                 630                 635                 640 


Ala Arg Asn Val Leu Val Thr Asp Asp Ser Val Met Lys Ile Ala Asp 
                645                 650                 655     


Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr 
            660                 665                 670         


Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe 
        675                 680                 685             


Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu 
    690                 695                 700                 


Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro 
705                 710                 715                 720 


Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys 
                725                 730                 735     


Pro Ser Thr Cys Thr His Glu Leu Tyr Met Met Met Arg Asp Cys Trp 
            740                 745                 750         


His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp 
        755                 760                 765             


Leu Asp Arg Ala Leu Ala Met Thr Ser Asn Gln Glu Tyr Leu Glu Leu 
    770                 775                 780                 


Ser Val Pro Leu Asp Gln Tyr Ser Pro Ser Tyr Pro Asp Thr Arg Ser 
785                 790                 795                 800 


Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Asp Ala Gly 
                805                 810                 815     


Ala Glu Glu Pro Cys Leu Pro Lys Phe Pro Pro His Ser Asn Gly Ala 
            820                 825                 830         


Ala Ile Lys Lys Arg 
        835         


<210>  11
<211>  785
<212>  PRT
<213>  Bos taurus

<400>  11

Met Val Ser Trp Gly Arg Phe Leu Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Asn Leu Val Asp Asp Thr Thr 
            20                  25                  30          


Val Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Arg Glu Ser Leu Glu Leu Arg Cys Leu Leu 
    50                  55                  60                  


Arg Asp Ala Ala Met Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ala Arg Asn 
            100                 105                 110         


Val Asp Ser Glu Thr Val Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Ala Asp Gly Ser Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Ser Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Thr Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Asp Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr 
305                 310                 315                 320 


Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp 
                325                 330                 335     


Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe 
            340                 345                 350         


His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Val Arg Glu Lys Glu 
        355                 360                 365             


Ile Pro Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
    370                 375                 380                 


Val Phe Phe Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met 
385                 390                 395                 400 


Arg Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
                405                 410                 415     


Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Ser Ala Glu Ser 
            420                 425                 430         


Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr Arg 
        435                 440                 445             


Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser Glu Tyr 
    450                 455                 460                 


Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr 
465                 470                 475                 480 


Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala 
                485                 490                 495     


Glu Ala Val Gly Ile Asp Lys Glu Lys Pro Lys Glu Ala Val Thr Val 
            500                 505                 510         


Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp 
        515                 520                 525             


Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn 
    530                 535                 540                 


Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val 
545                 550                 555                 560 


Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala 
                565                 570                 575     


Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro 
            580                 585                 590         


Glu Glu Gln Met Ala Phe Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu 
        595                 600                 605             


Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp 
    610                 615                 620                 


Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile 
625                 630                 635                 640 


Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys 
                645                 650                 655     


Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala 
            660                 665                 670         


Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly 
        675                 680                 685             


Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly 
    690                 695                 700                 


Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met 
705                 710                 715                 720 


Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp 
                725                 730                 735     


Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val 
            740                 745                 750         


Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu 
        755                 760                 765             


Asp Leu Ser Gln Pro Leu Glu Pro Tyr Ser Pro Cys Tyr Pro Asp Pro 
    770                 775                 780                 


Arg 
785 


<210>  12
<211>  390
<212>  PRT
<213>  Bos taurus

<400>  12

Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Met Leu Thr Pro Gly Arg Pro Val Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Asp Val Pro Pro Gly Pro Leu Pro Glu Ala Ile Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Thr Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Tyr Gly Asn Lys Ile Tyr Asp Lys Met Lys Ser Ser Ser 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Asp Val Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Thr Arg Arg Glu Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Lys Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Ser 
225                 230                 235                 240 


Ser Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu His 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  13
<211>  405
<212>  PRT
<213>  Oreochromis niloticus

<400>  13

Met Asn Leu Gly Lys Ala Leu Leu Phe Phe Leu Leu Ser Asn Cys Val 
1               5                   10                  15      


Thr Val Thr Phe Leu Leu Ser Thr Cys Thr Thr Val Asp Ile Lys His 
            20                  25                  30          


Ile Lys Lys Lys Arg Val Glu Ala Val Arg Gly Gln Ile Leu Ser Lys 
        35                  40                  45              


Leu Arg Leu Thr Ser Pro Pro Gln Thr Thr Gly Pro Ser Gln Val Pro 
    50                  55                  60                  


Phe Gln Val Leu Ala Leu Tyr Asn Ser Thr Lys Glu Leu Ile Glu Glu 
65                  70                  75                  80  


Leu Gly Lys Asp Arg Gln Gln Ser Cys Gly Gln Asp Asn Thr Glu Thr 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Ile Tyr Lys Phe Asn Met Ile Asn Gly Pro 
            100                 105                 110         


Gln Glu Asn Asn Asp Leu Pro Asn Cys Pro Arg Gly Ile Thr Pro Lys 
        115                 120                 125             


Ile Phe Arg Phe Asn Val Ser Ile Met Glu Lys Asn Ala Thr Asn Leu 
    130                 135                 140                 


Phe Arg Ala Glu Phe Arg Ala Leu Arg Ile Pro Asn Pro Ser Ala Arg 
145                 150                 155                 160 


Arg Asn Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Gln Lys Asp Asp 
                165                 170                 175     


Pro Lys Ala Lys Gln Arg Tyr Ile Gly Gly Lys Asn Val Leu Thr Lys 
            180                 185                 190         


Gly Thr Pro Glu Trp Val Ser Phe Asp Val Thr Glu Thr Val Arg Glu 
        195                 200                 205             


Trp Leu Met Asn Arg Arg Thr Asn Leu Gly Leu Glu Ile Ser Val His 
    210                 215                 220                 


Cys Pro Cys His Thr Phe Arg Pro Asn Gly Asp Ile Ile Glu Asn Ala 
225                 230                 235                 240 


Asn Glu Val Leu Glu Val Lys Phe Lys Gly Met Glu Ala Glu Tyr Asp 
                245                 250                 255     


Glu Gln Ser Arg Val Lys Ser Gln Lys Glu Gln Leu Tyr Pro His Leu 
            260                 265                 270         


Ile Leu Met Met Leu Pro Pro His Arg Leu Asp Ala Gln Ser Ser Ser 
        275                 280                 285             


Arg Arg Arg Lys Arg Ala Leu Asp Thr Asn Tyr Cys Phe Asn Asn Tyr 
    290                 295                 300                 


Glu Glu Asn Cys Cys Val Arg Gln Leu Tyr Ile Asn Phe Arg Glu Asp 
305                 310                 315                 320 


Leu Gly Trp Arg Trp Ile His Gln Pro Glu Gly Tyr Tyr Ala Asn Phe 
                325                 330                 335     


Cys Ser Gly Pro Cys Pro Tyr Leu Arg Ser Ala Asp Thr Thr His Ser 
            340                 345                 350         


Ser Leu Leu Ser Leu Tyr Asn Thr Leu Asn Pro Glu Ala Ser Ala Ser 
        355                 360                 365             


Pro Cys Cys Val Pro Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr 
    370                 375                 380                 


Val Gly Arg Ser Pro Lys Val Glu Gln Leu Ser Asn Met Val Val Lys 
385                 390                 395                 400 


Ser Cys Lys Cys Ser 
                405 


<210>  14
<211>  499
<212>  PRT
<213>  Bos taurus

<400>  14

Met Glu Ala Ala Ala Ala Thr Pro Arg Pro Arg Leu Phe Leu Leu Met 
1               5                   10                  15      


Leu Ala Ala Ala Ala Thr Leu Val Pro Glu Ala Thr Pro Leu Gln Cys 
            20                  25                  30          


Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly 
        35                  40                  45              


Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn 
    50                  55                  60                  


Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe 
65                  70                  75                  80  


Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Ile Thr Thr Thr Tyr Cys 
                85                  90                  95      


Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro Thr Val Gly Lys 
            100                 105                 110         


Pro Ser Ser Gly Leu Gly Pro Val Glu Leu Ala Ala Val Ile Ala Gly 
        115                 120                 125             


Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met Val Tyr Ile Cys 
    130                 135                 140                 


His Asn Arg Thr Val Ile His His Arg Val Pro Asn Glu Glu Asp Pro 
145                 150                 155                 160 


Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr Leu Lys Asp Leu 
                165                 170                 175     


Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly Leu Pro Leu Leu 
            180                 185                 190         


Val Gln Arg Thr Ile Ala Arg Thr Ile Val Leu Gln Glu Ser Ile Gly 
        195                 200                 205             


Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp Arg Gly Glu Glu 
    210                 215                 220                 


Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg Ser Trp Phe Arg 
225                 230                 235                 240 


Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His Glu Asn Ile Leu 
                245                 250                 255     


Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr Trp Thr Gln Leu 
            260                 265                 270         


Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu Phe Asp Tyr Leu 
        275                 280                 285             


Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys Leu Ala Leu Ser 
    290                 295                 300                 


Thr Ala Ser Gly Leu Ala His Leu His Met Glu Ile Val Gly Thr Gln 
305                 310                 315                 320 


Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile Leu 
                325                 330                 335     


Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu Gly Leu Ala Val 
            340                 345                 350         


Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala Pro Asn His Arg 
        355                 360                 365             


Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Asp Ser Ile 
    370                 375                 380                 


Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Asp Ile Tyr Ala Met 
385                 390                 395                 400 


Gly Leu Val Phe Trp Glu Val Ala Arg Arg Cys Ser Ile Gly Gly Ile 
                405                 410                 415     


His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val Pro Ser Asp Pro 
            420                 425                 430         


Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln Lys Leu Arg Pro 
        435                 440                 445             


Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu Arg Val Met Ala 
    450                 455                 460                 


Lys Ile Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala Ala Arg Leu Thr 
465                 470                 475                 480 


Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser Gln Gln Glu Gly 
                485                 490                 495     


Ile Lys Met 
            


<210>  15
<211>  452
<212>  PRT
<213>  Bos taurus

<400>  15

Met His Leu Leu Ala Lys Pro Gln Ser Ser Gly Ser Arg Glu Ala Ala 
1               5                   10                  15      


Trp Phe Ser Ser Leu Leu Leu His Asp Cys Arg Gly Leu Leu Leu Pro 
            20                  25                  30          


Gly Leu Ala Ala Phe Leu Pro Gly Pro Arg Leu Lys Met His Leu Gln 
        35                  40                  45              


Arg Ala Leu Val Val Leu Ala Leu Leu Asn Phe Ala Thr Val Ser Leu 
    50                  55                  60                  


Ser Met Ser Thr Cys Thr Thr Leu Asp Phe Asn His Ile Lys Arg Lys 
65                  70                  75                  80  


Arg Val Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Thr 
                85                  90                  95      


Ser Pro Pro Asp Pro Ser Gly Leu Ala Ser Val Pro Ile Gln Val Leu 
            100                 105                 110         


Asp Leu Tyr Asn Ser Thr Arg Glu Leu Leu Glu Glu Val His Gly Glu 
        115                 120                 125             


Arg Gly Asp Val Cys Thr Gln Ala Asn Thr Glu Ser Glu Tyr Tyr Ala 
    130                 135                 140                 


Lys Glu Ile Tyr Lys Phe Asp Met Ile Gln Gly Leu Glu Glu His Asn 
145                 150                 155                 160 


Asp Leu Thr Val Cys Pro Lys Gly Ile Thr Ser Lys Ile Phe Arg Phe 
                165                 170                 175     


Asn Val Ser Ser Val Glu Lys Asn Glu Thr Asn Leu Phe Arg Ala Glu 
            180                 185                 190         


Phe Arg Val Phe Arg Met Pro Asn Pro Ala Ser Lys Arg Ser Glu Gln 
        195                 200                 205             


Arg Ile Glu Leu Phe Gln Ile Leu Gln Pro Gly Glu His Ile Ala Lys 
    210                 215                 220                 


Gln Arg Tyr Ile Asp Gly Lys Asn Leu Pro Thr Arg Gly Thr Gly Glu 
225                 230                 235                 240 


Trp Leu Ser Phe Asp Val Thr Asp Thr Val Arg Glu Trp Leu Leu Arg 
                245                 250                 255     


Arg Glu Ser Asn Leu Gly Leu Glu Ile Ser Ile His Cys Pro Cys His 
            260                 265                 270         


Thr Phe Gln Pro Asn Gly Asp Ile Leu Glu Asn Ile Gln Glu Leu Met 
        275                 280                 285             


Glu Ile Lys Phe Lys Gly Val Asp Ser Asp Asp Asp Pro Gly Arg Gly 
    290                 295                 300                 


Asp Leu Gly Arg Leu Lys Lys Lys Lys Glu His Ile Pro His Leu Ile 
305                 310                 315                 320 


Leu Met Met Ile Pro Pro Asn Arg Leu Asp Ser Pro Gly His Ser Gln 
                325                 330                 335     


Arg Lys Lys Arg Ala Leu Asp Thr Asn Tyr Cys Phe Arg Asn Leu Glu 
            340                 345                 350         


Glu Asn Cys Cys Val Arg Pro Leu Tyr Ile Asp Phe Arg Gln Asp Leu 
        355                 360                 365             


Gly Trp Lys Trp Val His Glu Pro Lys Gly Tyr Tyr Ala Asn Phe Cys 
    370                 375                 380                 


Ser Gly Pro Cys Pro Tyr Leu Arg Ser Ser Asp Thr Thr His Ser Thr 
385                 390                 395                 400 


Val Leu Gly Leu Tyr Asn Thr Leu Asn Pro Glu Ala Ser Ala Ser Pro 
                405                 410                 415     


Cys Cys Val Pro Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Val 
            420                 425                 430         


Gly Arg Thr Pro Lys Val Glu Gln Leu Ser Asn Met Val Val Lys Ser 
        435                 440                 445             


Cys Lys Cys Ser 
    450         


<210>  16
<211>  405
<212>  PRT
<213>  Oreochromis niloticus

<400>  16

Met Asn Leu Gly Lys Ala Leu Leu Phe Phe Leu Leu Ser Asn Cys Val 
1               5                   10                  15      


Thr Val Thr Phe Leu Leu Ser Thr Cys Thr Thr Val Asp Ile Lys His 
            20                  25                  30          


Ile Lys Lys Lys Arg Val Glu Ala Val Arg Gly Gln Ile Leu Ser Lys 
        35                  40                  45              


Leu Arg Leu Thr Ser Pro Pro Gln Thr Thr Gly Pro Ser Gln Val Pro 
    50                  55                  60                  


Phe Gln Val Leu Ala Leu Tyr Asn Ser Thr Lys Glu Leu Ile Glu Glu 
65                  70                  75                  80  


Leu Gly Lys Asp Arg Gln Gln Ser Cys Gly Gln Asp Asn Thr Glu Thr 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Ile Tyr Lys Phe Asn Met Ile Asn Gly Pro 
            100                 105                 110         


Gln Glu Asn Asn Asp Leu Pro Asn Cys Pro Arg Gly Ile Thr Pro Lys 
        115                 120                 125             


Ile Phe Arg Phe Asn Val Ser Ile Met Glu Lys Asn Ala Thr Asn Leu 
    130                 135                 140                 


Phe Arg Ala Glu Phe Arg Ala Leu Arg Ile Pro Asn Pro Ser Ala Arg 
145                 150                 155                 160 


Arg Asn Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Gln Lys Asp Asp 
                165                 170                 175     


Pro Lys Ala Lys Gln Arg Tyr Ile Gly Gly Lys Asn Val Leu Thr Lys 
            180                 185                 190         


Gly Thr Pro Glu Trp Val Ser Phe Asp Val Thr Glu Thr Val Arg Glu 
        195                 200                 205             


Trp Leu Met Asn Arg Arg Thr Asn Leu Gly Leu Glu Ile Ser Val His 
    210                 215                 220                 


Cys Pro Cys His Thr Phe Arg Pro Asn Gly Asp Ile Ile Glu Asn Ala 
225                 230                 235                 240 


Asn Glu Val Leu Glu Val Lys Phe Lys Gly Met Glu Ala Glu Tyr Asp 
                245                 250                 255     


Glu Gln Ser Arg Val Lys Ser Gln Lys Glu Gln Leu Tyr Pro His Leu 
            260                 265                 270         


Ile Leu Met Met Leu Pro Pro His Arg Leu Asp Ala Gln Ser Ser Ser 
        275                 280                 285             


Arg Arg Arg Lys Arg Ala Leu Asp Thr Asn Tyr Cys Phe Asn Asn Tyr 
    290                 295                 300                 


Glu Glu Asn Cys Cys Val Arg Gln Leu Tyr Ile Asn Phe Arg Glu Asp 
305                 310                 315                 320 


Leu Gly Trp Arg Trp Ile His Gln Pro Glu Gly Tyr Tyr Ala Asn Phe 
                325                 330                 335     


Cys Ser Gly Pro Cys Pro Tyr Leu Arg Ser Ala Asp Thr Thr His Ser 
            340                 345                 350         


Ser Leu Leu Ser Leu Tyr Asn Thr Leu Asn Pro Glu Ala Ser Ala Ser 
        355                 360                 365             


Pro Cys Cys Val Pro Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr 
    370                 375                 380                 


Val Gly Arg Ser Pro Lys Val Glu Gln Leu Ser Asn Met Val Val Lys 
385                 390                 395                 400 


Ser Cys Lys Cys Ser 
                405 


<210>  17
<211>  588
<212>  PRT
<213>  Oreochromis niloticus

<400>  17

Met Lys Ala Arg Arg Cys Ser Leu Thr Phe Arg Gly Val Leu Ser Ala 
1               5                   10                  15      


Phe Leu Ile Ser Val Leu Leu Glu Pro Gly Ala Ala Gly Leu Asp Val 
            20                  25                  30          


Phe Gln Leu His Glu Leu Cys Lys Phe Cys Asp Val Glu Pro Thr Ser 
        35                  40                  45              


Cys Asn Gly Thr Gly Ile Cys Lys Thr Asp Cys Ser Ile Ser Ser Ile 
    50                  55                  60                  


Cys Glu Lys Pro Thr Glu Val Cys Val Ser Ile Trp Arg Arg Asn Glu 
65                  70                  75                  80  


Thr Asn Leu Ser Ile Glu Thr Leu Cys His Asn Pro Ala Glu Pro Leu 
                85                  90                  95      


Tyr Gly Ile Thr Leu Asp Asp Tyr Asn Ser Thr Thr Cys Val Met Lys 
            100                 105                 110         


Glu Lys Asn Thr Thr Thr Gly Leu Ala His Phe Cys Ser Cys Lys Gly 
        115                 120                 125             


Ala Glu Cys Asn Glu Glu Leu Ile Phe Ser Gln Thr Val Asp Pro Thr 
    130                 135                 140                 


Pro Asp Pro Leu Glu Ser Asn Asp Ser Leu Met Ser Val Val Leu Val 
145                 150                 155                 160 


Ser Met Leu Pro Leu Leu Val Met Val Ile Ala Phe Phe Gly Met Phe 
                165                 170                 175     


Tyr Trp Cys Arg Ile His Arg Gln Arg Arg Pro Asn Arg Gln Trp Glu 
            180                 185                 190         


Ser Ser Phe Asn Phe Lys Arg Lys Pro Ile Ala Gly Gly Leu Asp Cys 
        195                 200                 205             


Ser Asp Ala Cys Ala Ile Met Thr Asp Asp Asp Lys Ser Asp Ser Ser 
    210                 215                 220                 


Ser Thr His Ala Asn Ser Leu Asn His Asn Thr Glu Pro Leu Pro Ile 
225                 230                 235                 240 


Glu Leu Asp Leu Leu Val Gly Lys Gly Arg Phe Ala Gln Val Tyr Lys 
                245                 250                 255     


Ala Lys Leu Lys Gln Thr Thr Trp Asn Gln Phe Glu Thr Val Ala Val 
            260                 265                 270         


Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys Asn Glu Lys Asp 
        275                 280                 285             


Ile Phe Ser Asn Thr Asp Leu Arg His Glu Asn Ile Leu His Phe Leu 
    290                 295                 300                 


Thr Ala Glu Glu Arg Lys Val Glu Lys Gln Tyr Trp Leu Ile Thr Ala 
305                 310                 315                 320 


Phe His Pro Arg Gly Asn Leu Gln Glu Tyr Leu Thr His His Val Ile 
                325                 330                 335     


Ser Trp Gln Glu Leu Gln Val Leu Ser Ser Ser Leu Ala Arg Gly Val 
            340                 345                 350         


Ala His Leu His Ser Asp Arg Leu Pro Cys Gly Arg Pro Lys Val Pro 
        355                 360                 365             


Ile Val His Arg Asp Leu Lys Ser Ser Asn Ile Leu Val Lys Asn Asp 
    370                 375                 380                 


Gly Thr Cys Cys Val Cys Asp Phe Gly Leu Gly Leu Cys Leu Asp Ser 
385                 390                 395                 400 


Ser Leu Ser Val Asp Asp Leu Ala Asn Ser Gly Gln Val Gly Thr Ala 
                405                 410                 415     


Arg Tyr Met Ala Pro Glu Val Leu Glu Ala Arg Leu Asn Leu Glu Asn 
            420                 425                 430         


Ile Glu Ser Phe Lys Gln Thr Asp Ile Tyr Ser Met Ala Leu Val Leu 
        435                 440                 445             


Trp Glu Met Thr Ser Arg Cys Glu Ala Ile Gly Glu Val Lys Asp Tyr 
    450                 455                 460                 


Glu Pro Ala Tyr Gly Ser Lys Val Arg Glu His Pro Cys Val Glu Ser 
465                 470                 475                 480 


Met Lys Asp Asn Val Leu Arg Asp Arg Gly Arg Pro Glu Ile Pro Asp 
                485                 490                 495     


Ser Trp Leu Arg His Gln Gly Met Ala Val Met Cys Ala Thr Ile Lys 
            500                 505                 510         


Glu Cys Trp Asp His Asp Pro Glu Ala Arg Leu Thr Ala His Cys Ile 
        515                 520                 525             


Ala Glu Arg Ile Ser Glu Leu Glu Asp Glu Met Gly Lys Leu Ser Ser 
    530                 535                 540                 


Arg Ser Ser Ser Ala Glu Lys Ile Val Glu Glu Leu Lys Ile Pro Ile 
545                 550                 555                 560 


Glu Val Glu Ile Pro Glu Glu Glu Val Lys Ile Thr Glu Ile Gln Asn 
                565                 570                 575     


Ile Ile Ala Val Asp Cys Ser Ile Ser Asp Lys Lys 
            580                 585             


<210>  18
<211>  832
<212>  PRT
<213>  Bos taurus

<400>  18

Met Trp Ser Arg Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Lys Pro Ala Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Leu Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Asp Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Arg Gly Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys His Ser Gly Ile Asn Ser Ser Asp 
305                 310                 315                 320 


Ala Glu Val Leu Thr Leu Phe Asn Val Thr Glu Ala Gln Ser Gly Glu 
                325                 330                 335     


Tyr Val Cys Lys Val Ser Asn Tyr Ile Gly Glu Ala Asn Gln Ser Ala 
            340                 345                 350         


Trp Leu Thr Val Thr Arg Pro Val Ala Lys Ala Leu Glu Glu Arg Pro 
        355                 360                 365             


Ala Val Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr 
    370                 375                 380                 


Gly Ala Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Ile Tyr Lys 
385                 390                 395                 400 


Met Lys Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val 
                405                 410                 415     


His Lys Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser 
            420                 425                 430         


Ala Asp Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro 
        435                 440                 445             


Ser Arg Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu 
    450                 455                 460                 


Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu 
465                 470                 475                 480 


Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu 
                485                 490                 495     


Ala Glu Ala Ile Gly Leu Asp Lys Asp Arg Pro Asn Arg Val Thr Lys 
            500                 505                 510         


Val Ala Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser 
        515                 520                 525             


Asp Leu Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys 
    530                 535                 540                 


Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr 
545                 550                 555                 560 


Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln 
                565                 570                 575     


Ala Arg Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His His 
            580                 585                 590         


Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln 
        595                 600                 605             


Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg 
    610                 615                 620                 


Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys 
625                 630                 635                 640 


Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr 
                645                 650                 655     


Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu 
            660                 665                 670         


Ala Leu Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe 
        675                 680                 685             


Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro 
    690                 695                 700                 


Gly Val Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg 
705                 710                 715                 720 


Met Asp Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg 
                725                 730                 735     


Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu 
            740                 745                 750         


Val Glu Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr 
        755                 760                 765             


Leu Asp Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp 
    770                 775                 780                 


Thr Arg Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His 
785                 790                 795                 800 


Glu Pro Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu 
                805                 810                 815     


Ala Asn Gly Gly Leu Lys Arg Arg Asp Tyr Lys Asp Asp Asp Asp Lys 
            820                 825                 830         


<210>  19
<211>  171
<212>  PRT
<213>  Oreochromis niloticus

<400>  19

Met Ser Ser Ala Phe Ser Phe Gln Trp His Leu Cys Asp Val Phe Lys 
1               5                   10                  15      


Ser Ala Met Cys Cys Ile Ser Cys Ser His Thr Leu Ser Leu Leu Leu 
            20                  25                  30          


Cys Val Leu Thr Leu Thr Pro Thr Ala Thr Gly Ala Gly Pro Glu Thr 
        35                  40                  45              


Leu Cys Gly Ala Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Glu 
    50                  55                  60                  


Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Pro Ser Ala Arg 
65                  70                  75                  80  


Arg Ser Arg Gly Ile Val Asp Glu Cys Cys Phe Gln Ser Cys Glu Leu 
                85                  90                  95      


Gln Arg Leu Glu Met Tyr Cys Ala Pro Val Lys Thr Pro Lys Ile Ser 
            100                 105                 110         


Arg Ser Val Arg Ser Gln Arg His Thr Asp Met Pro Arg Ala Pro Lys 
        115                 120                 125             


Val Ser Ser Arg Ala Asn Lys Gly Thr Glu Arg Arg Thr Ala Pro Gln 
    130                 135                 140                 


Pro Asp Lys Thr Lys Asn Lys Lys Glu Val His Gln Lys Asn Ser Ser 
145                 150                 155                 160 


Arg Gly Ser Ser Gly Gly Arg Asn Tyr Arg Met 
                165                 170     


<210>  20
<211>  640
<212>  PRT
<213>  Bos taurus

<400>  20

Asn Ala Ile Phe Val Pro Arg Pro Glu Arg Lys Arg Arg Glu Val Met 
1               5                   10                  15      


Gln Ile Ala Asn Thr Thr Met Ser Ser Arg Ser Arg Asn Thr Thr Val 
            20                  25                  30          


Leu Asp Thr Tyr Asn Ile Thr Asp Pro Glu Glu Leu Glu Thr Glu Tyr 
        35                  40                  45              


Pro Phe Phe Glu Ser Arg Val Asp Asn Lys Glu Arg Thr Val Ile Ser 
    50                  55                  60                  


Asn Leu Arg Pro Phe Thr Leu Tyr Arg Ile Asp Ile His Ser Cys Asn 
65                  70                  75                  80  


His Glu Ala Glu Lys Leu Gly Cys Ser Ala Ser Asn Phe Val Phe Ala 
                85                  90                  95      


Arg Thr Met Pro Ala Glu Gly Ala Asp Asp Ile Pro Gly Pro Val Thr 
            100                 105                 110         


Trp Glu Pro Arg Pro Glu Asn Ser Ile Phe Leu Lys Trp Pro Glu Pro 
        115                 120                 125             


Glu Asn Pro Asn Gly Leu Ile Leu Met Tyr Glu Ile Lys Tyr Gly Ser 
    130                 135                 140                 


Gln Val Glu Asp Gln Arg Glu Cys Val Ser Arg Gln Glu Tyr Arg Lys 
145                 150                 155                 160 


Tyr Gly Gly Ala Lys Leu Asn Arg Leu Asn Pro Gly Asn Tyr Thr Ala 
                165                 170                 175     


Arg Ile Gln Ala Thr Ser Leu Ser Gly Asn Gly Ser Trp Thr Asp Pro 
            180                 185                 190         


Val Phe Phe Tyr Val Gln Ala Lys Thr Thr Tyr Glu Asn Phe Ile His 
        195                 200                 205             


Leu Met Ile Ala Leu Pro Ile Ala Val Leu Leu Ile Val Gly Gly Leu 
    210                 215                 220                 


Val Ile Met Leu Tyr Val Phe His Arg Lys Arg Asn Ser Ser Arg Leu 
225                 230                 235                 240 


Gly Asn Gly Val Leu Tyr Ala Ser Val Asn Pro Glu Tyr Phe Ser Ala 
                245                 250                 255     


Ala Asp Val Tyr Val Pro Asp Glu Trp Glu Val Ala Arg Glu Lys Ile 
            260                 265                 270         


Thr Met Ser Arg Glu Leu Gly Gln Gly Ser Phe Gly Met Val Tyr Glu 
        275                 280                 285             


Gly Val Ala Lys Gly Val Val Lys Asp Glu Pro Glu Thr Arg Val Ala 
    290                 295                 300                 


Ile Lys Thr Val Asn Glu Ala Ala Ser Met Arg Glu Arg Ile Glu Phe 
305                 310                 315                 320 


Leu Asn Glu Ala Ser Val Met Lys Glu Phe Asn Cys His His Val Val 
                325                 330                 335     


Arg Leu Leu Gly Val Val Ser Gln Gly Gln Pro Thr Leu Val Ile Met 
            340                 345                 350         


Glu Leu Met Thr Arg Gly Asp Leu Lys Ser Tyr Leu Arg Ser Leu Arg 
        355                 360                 365             


Pro Glu Met Glu Asn Asn Pro Val Leu Ala Pro Pro Ser Leu Ser Lys 
    370                 375                 380                 


Met Ile Gln Met Ala Gly Glu Ile Ala Asp Gly Met Ala Tyr Leu Asn 
385                 390                 395                 400 


Ala Asn Lys Phe Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Val 
                405                 410                 415     


Ala Glu Asp Phe Thr Val Lys Ile Gly Asp Phe Gly Met Thr Arg Asp 
            420                 425                 430         


Ile Tyr Glu Thr Asp Tyr Tyr Arg Lys Gly Gly Lys Gly Leu Leu Pro 
        435                 440                 445             


Val Arg Trp Met Ser Pro Glu Ser Leu Lys Asp Gly Val Phe Thr Thr 
    450                 455                 460                 


His Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile Ala Thr 
465                 470                 475                 480 


Leu Ala Glu Gln Pro Tyr Gln Gly Leu Ser Asn Glu Gln Val Leu Arg 
                485                 490                 495     


Phe Val Met Glu Gly Gly Leu Leu Asp Lys Pro Asp Asn Cys Pro Asp 
            500                 505                 510         


Met Leu Phe Glu Leu Met Arg Met Cys Trp Gln Tyr Asn Pro Lys Met 
        515                 520                 525             


Arg Pro Ser Phe Leu Glu Ile Ile Ser Ser Val Lys Asp Glu Met Glu 
    530                 535                 540                 


Ala Gly Phe Arg Glu Val Ser Phe Tyr Tyr Ser Glu Glu Asn Lys Pro 
545                 550                 555                 560 


Pro Glu Pro Glu Glu Leu Asp Leu Glu Pro Glu Asn Met Glu Ser Val 
                565                 570                 575     


Pro Leu Asp Pro Ser Ala Ser Ser Ala Ser Leu Pro Leu Pro Asp Arg 
            580                 585                 590         


His Ser Gly His Lys Ala Glu Asn Gly Pro Gly Pro Gly Val Leu Val 
        595                 600                 605             


Leu Arg Ala Ser Phe Asp Glu Arg Gln Pro Tyr Ala His Met Asn Gly 
    610                 615                 620                 


Gly Arg Lys Asn Glu Arg Ala Leu Pro Leu Pro Gln Ser Ser Thr Cys 
625                 630                 635                 640 


<210>  21
<211>  148
<212>  PRT
<213>  Oreochromis niloticus

<400>  21

Phe Gly Met Val Tyr Glu Gly Ile Ala Lys Gly Val Val Lys Asp Glu 
1               5                   10                  15      


Pro Glu Thr Arg Val Ala Ile Lys Thr Val Asn Glu Ser Ala Ser Met 
            20                  25                  30          


Arg Glu Arg Ile Glu Phe Leu Asn Glu Ala Ser Val Met Arg Glu Phe 
        35                  40                  45              


Asn Cys His His Val Val Arg Leu Leu Gly Val Val Ser Gln Gly Gln 
    50                  55                  60                  


Pro Thr Leu Val Ile Met Glu Leu Met Thr Arg Gly Asp Leu Lys Ser 
65                  70                  75                  80  


Tyr Leu Arg Ser Leu Arg Pro Lys Glu Gln Gln Trp Ser Ser Leu Ser 
                85                  90                  95      


Leu Pro Pro Leu Lys Lys Met Leu Gln Met Ala Gly Gln Ile Ala Asp 
            100                 105                 110         


Gly Met Ala Tyr Leu Asn Ala Asn Lys Phe Val His Arg Asp Leu Ala 
        115                 120                 125             


Ala Arg Asn Cys Met Val Ala Glu Asp Phe Thr Val Lys Ile Gly Asp 
    130                 135                 140                 


Phe Gly Met Thr 
145             


<210>  22
<211>  211
<212>  PRT
<213>  Bos taurus

<400>  22

Met Arg Thr Trp Ala Cys Leu Leu Leu Leu Gly Cys Gly Tyr Leu Ala 
1               5                   10                  15      


Asn Ala Leu Ala Glu Glu Ala Glu Ile Pro Arg Glu Val Ile Glu Arg 
            20                  25                  30          


Leu Ala His Ser Gln Ile His Ser Ile Arg Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


Glu Ile Asp Ser Val Gly Ala Glu Glu Pro Leu Glu Thr Ser Leu Arg 
    50                  55                  60                  


Ala His Gly Gly His Gly Ala Lys His Ala Leu Glu Lys Arg Pro Val 
65                  70                  75                  80  


Pro Ile Arg Arg Lys Arg Ser Ile Glu Glu Ala Ile Pro Ala Val Cys 
                85                  90                  95      


Lys Thr Arg Thr Val Ile Tyr Glu Ile Pro Arg Ser Gln Val Asp Pro 
            100                 105                 110         


Thr Ser Ala Asn Phe Leu Ile Trp Pro Pro Cys Val Glu Val Lys Arg 
        115                 120                 125             


Cys Thr Gly Cys Cys Asn Thr Ser Ser Val Lys Cys Gln Pro Ser Arg 
    130                 135                 140                 


Val His His Arg Asn Val Lys Val Ala Lys Val Glu Tyr Phe Arg Lys 
145                 150                 155                 160 


Lys Ala Lys Leu Lys Glu Val Gln Val Arg Leu Glu Glu His Leu Glu 
                165                 170                 175     


Cys Thr Cys Thr Ser Ala Ser Pro Ser Pro Asp His Arg Glu Glu Glu 
            180                 185                 190         


Ala Gly Arg Arg Arg Glu Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu 
        195                 200                 205             


Lys Pro Thr 
    210     


<210>  23
<211>  199
<212>  PRT
<213>  Oreochromis niloticus

<400>  23

Met Arg Ala Ala Val Tyr His Ile Leu Ala Gly Tyr Leu Cys Val Leu 
1               5                   10                  15      


Arg Thr Val Ala Gln Glu Ser Pro Leu Pro Gln Glu Leu Leu Glu Arg 
            20                  25                  30          


Leu Ser Arg Ser Glu Ile Arg Ser Ile Ser Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


Glu Ile Asp Ser Val Glu Asn Glu Val Ser Glu Glu Thr Lys His Ser 
    50                  55                  60                  


Tyr His Lys Asp Val Ser His Ser Phe Pro Asp Leu Lys Arg Ala His 
65                  70                  75                  80  


Thr His Thr Arg His Arg Arg Ser Ala Met Val Glu Glu Ala Leu Pro 
                85                  90                  95      


Ala Val Cys Lys Val Arg Thr Ala Ile Tyr Glu Ile Pro Arg Ser Gln 
            100                 105                 110         


Val Asp Pro Thr Ser Ala Asn Phe Ile Ile Trp Pro Pro Cys Val Glu 
        115                 120                 125             


Val Lys Arg Cys Thr Gly Cys Cys Asn Thr Ser Asn Met Arg Cys Gln 
    130                 135                 140                 


Ala Ala Arg Lys His Tyr Arg Thr Val Lys Val Ala Lys Val Glu Tyr 
145                 150                 155                 160 


Val Arg Arg Arg Pro Lys Leu Arg Glu Val Gln Val Arg Leu Glu Asp 
                165                 170                 175     


His Leu Glu Cys Met Cys Thr Asn Lys Arg His Ile Ser Pro Asn Ser 
            180                 185                 190         


Asp Thr Asp Asn Gly Ile Arg 
        195                 


<210>  24
<211>  1098
<212>  PRT
<213>  Bos taurus

<400>  24

Met Gly Thr Ser His Trp Ala Leu Leu Val Leu Gly Cys Leu Phe Thr 
1               5                   10                  15      


Gly Pro Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Arg Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Tyr Pro Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Val Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Met Asp Glu Asn Glu Ile 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Ser Leu Val Ile Val Glu Asp Glu Asp 
    130                 135                 140                 


Ser Val Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu Leu Ser Ser Glu Gly Ile Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Lys Gly Thr Phe Ser Val Gly Leu Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Arg Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Tyr 
        195                 200                 205             


Thr Ala Thr Ser Lys Leu Asp Leu Glu Met Glu Ser Pro Lys Thr Val 
    210                 215                 220                 


Tyr Lys Ala Gly Glu Ser Ile Val Val Thr Cys Thr Val Phe Asn Asn 
225                 230                 235                 240 


Glu Val Val Asp Phe Gln Trp Thr Tyr Pro Gly Gln Met Lys Gly Lys 
                245                 250                 255     


Gly Ile Thr Arg Leu Glu Glu Thr Lys Phe Pro Ser Ile Lys Leu Val 
            260                 265                 270         


Tyr Thr Leu Arg Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 
        275                 280                 285             


Glu Cys Ala Ala His Gln Ala Thr Lys Glu Val Lys Lys Met Arg Asn 
    290                 295                 300                 


Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Asn 
305                 310                 315                 320 


Phe Asn Leu Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 
                325                 330                 335     


Val Asp Val Gln Ala Tyr Pro Pro Pro Lys Ile Thr Trp Leu Lys Asp 
            340                 345                 350         


Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Ile Glu 
        355                 360                 365             


Lys Ile Gln Glu Ile Ser Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 
    370                 375                 380                 


Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Val Gln Asn Glu Asp 
385                 390                 395                 400 


Asp Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 
                405                 410                 415     


Ile Leu Asp Leu Val Asp Asp His His Gly Ser Asn Gly Gly Gln Thr 
            420                 425                 430         


Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 
        435                 440                 445             


Val Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Val 
    450                 455                 460                 


Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Gly Val His Pro Arg Asp 
465                 470                 475                 480 


Arg Ser Thr Val Glu Gly Gln Val Thr Phe Ala Lys Val Glu Glu Thr 
                485                 490                 495     


Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Val Glu Ser Arg 
            500                 505                 510         


Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala 
        515                 520                 525             


Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
    530                 535                 540                 


Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 
545                 550                 555                 560 


Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 
                565                 570                 575     


Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly 
            580                 585                 590         


Leu Val Leu Gly Arg Ile Leu Gly Ser Gly Ala Phe Gly Lys Val Val 
        595                 600                 605             


Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 
    610                 615                 620                 


Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 
625                 630                 635                 640 


Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 
                645                 650                 655     


Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 
            660                 665                 670         


Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 
        675                 680                 685             


Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu 
    690                 695                 700                 


Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr 
705                 710                 715                 720 


Val Ile Leu Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln 
                725                 730                 735     


Ala Asp Thr Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser 
            740                 745                 750         


Lys Tyr Ser Asp Ile Gln Arg Ala Leu Tyr Asp Arg Pro Ala Ser Tyr 
        755                 760                 765             


Lys Lys Lys Ser Met Leu Asp Ser Glu Val Lys Asn Leu Leu Ser Asp 
    770                 775                 780                 


Asp Asn Ser Glu Gly Leu Thr Leu Leu Asp Leu Leu Ser Phe Thr Tyr 
785                 790                 795                 800 


Gln Val Ala Arg Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His 
                805                 810                 815     


Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Ala Gln Gly Lys Ile Val 
            820                 825                 830         


Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Met His Asp Ser Asn 
        835                 840                 845             


Tyr Val Ser Lys Gly Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro 
    850                 855                 860                 


Glu Ser Ile Phe Asp Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser 
865                 870                 875                 880 


Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr 
                885                 890                 895     


Pro Gly Met Met Val Asp Ser Thr Phe Tyr Asn Lys Ile Lys Ser Gly 
            900                 905                 910         


Tyr Arg Met Ala Lys Pro Asp His Ala Thr Ser Glu Val Tyr Glu Ile 
        915                 920                 925             


Met Val Lys Cys Trp Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Tyr 
    930                 935                 940                 


His Leu Ser Glu Ile Val Glu Asn Leu Leu Pro Gly Gln Tyr Lys Lys 
945                 950                 955                 960 


Ser Tyr Glu Lys Ile His Leu Asp Phe Leu Lys Ser Asp His Pro Ala 
                965                 970                 975     


Val Ala Arg Met Arg Val Asp Ser Asp Asn Ala Tyr Ile Gly Val Thr 
            980                 985                 990         


Tyr Lys Asn Glu Glu Asp Lys Leu  Lys Asp Trp Glu Gly  Gly Leu Asp 
        995                 1000                 1005             


Glu Gln  Arg Leu Ser Ala Asp  Ser Gly Tyr Ile Ile  Pro Leu Pro 
    1010                 1015                 1020             


Asp Ile  Asp Pro Val Pro Glu  Glu Glu Asp Leu Gly  Lys Arg Asn 
    1025                 1030                 1035             


Arg His  Arg Ile Phe Leu Ser  Leu Pro His Ser Val  Asp Tyr Ile 
    1040                 1045                 1050             


Lys Ile  Phe Lys Gln Lys His  Ile Ala Ser Glu Lys  Ala Met Ala 
    1055                 1060                 1065             


Ser Tyr  Ser Ser Thr Leu Ala  Trp Lys Ile Pro Trp  Met Glu Glu 
    1070                 1075                 1080             


Pro Gly  Arg Leu Gln Ser Met  Gly Leu Leu Arg Val  Arg His Asp 
    1085                 1090                 1095             


<210>  25
<211>  1066
<212>  PRT
<213>  Oreochromis niloticus

<400>  25

Lys Tyr Ser Leu Phe Met Thr His Cys Met Cys Leu Leu Ser Ala Pro 
1               5                   10                  15      


Thr Ala Gly Met Ile Pro Ser Ser Ser Val Pro Leu Leu Leu Pro Lys 
            20                  25                  30          


Leu Asp Glu Met Val Val Thr Leu His Thr Pro Phe Thr Leu Thr Cys 
        35                  40                  45              


His Gly Gln Glu Asn Leu Gly Trp Glu Thr Pro Ile Asp Val Ser Glu 
    50                  55                  60                  


Gln Thr Gln Glu Asp Pro Asn Gly Leu Phe Ile Ser Thr Ile Thr Val 
65                  70                  75                  80  


Asp Ser Ala Thr Ala Ser His Thr Gly Tyr Tyr Thr Cys Phe Tyr Ser 
                85                  90                  95      


Arg Thr Phe Ala Glu Asp Thr Ala Glu Phe Ser Arg Ile Tyr Ile Tyr 
            100                 105                 110         


Val Pro Asp Pro Asp Val Pro Phe Leu Glu Ser Leu Ile Pro Phe Gly 
        115                 120                 125             


Tyr His Val Leu Ser Gly Tyr Asp Glu Met Glu Ile Gln Cys Arg Val 
    130                 135                 140                 


Ser Asp Pro Asn Ala Asn Val Thr Leu Ile Asn Ser Asp Thr Gln Gln 
145                 150                 155                 160 


Pro Val Pro Ser Ile Tyr Asp Ser Lys Arg Gly Ala Leu Gly Ile Phe 
                165                 170                 175     


Thr Ala Gly Thr Tyr Val Cys Lys Ala Val Ile Asn Gly His Glu Phe 
            180                 185                 190         


Tyr Ser Glu Glu Tyr Ile Val His Gly Ser Thr Asp Lys Asp Thr Asn 
        195                 200                 205             


Glu Leu Asp Val Glu Leu Thr Ala Lys Lys Thr Ala Leu Leu Val Gly 
    210                 215                 220                 


Asp Thr Ile Thr Val Thr Cys Val Ala Arg Gly Ser Glu Ile Leu Glu 
225                 230                 235                 240 


Asp His Trp Lys Tyr Pro Gly Lys Leu Ala Asn Arg Gly Thr Lys Thr 
                245                 250                 255     


Val Arg Glu Asn Lys Arg Thr Gln Glu Ile Phe Tyr Thr Leu Thr Ile 
            260                 265                 270         


Pro Gln Ala Ser Thr Lys Asp Ser Gly Ile Tyr Ser Cys Ser Ile Thr 
        275                 280                 285             


Asp Ile Leu Ser Asn Thr Ser Glu Phe Leu Ser Val Lys Pro Glu Phe 
    290                 295                 300                 


Arg Glu Tyr Glu Ser Ala Ala Leu Asp Glu Val Arg Glu Phe Lys Ala 
305                 310                 315                 320 


Val Val Asn Ser Phe Pro Ser Val His Val Ser Trp Phe Lys Asp Gly 
                325                 330                 335     


Tyr Pro Leu Ser Asp Val Thr Ala Glu Ile Ser Thr Ser Leu Gln Gln 
            340                 345                 350         


Thr Ser Glu Ile Ser Tyr Met Ser Val Leu Thr Leu Ile Arg Ala Lys 
        355                 360                 365             


Glu Glu Asp Ser Gly Asn Tyr Thr Met Arg Val Glu Asn Arg Asn Gln 
    370                 375                 380                 


Ser Arg Asp Ile Ser Leu Ile Leu Glu Val Lys Val Pro Ala Val Ile 
385                 390                 395                 400 


Val Asp Leu Met Asp Val His His Gly Ser Ala Gln Gly Gln Ser Val 
                405                 410                 415     


Val Cys Ile Thr Arg Gly Gln Pro Thr Pro Met Val Glu Trp Phe Val 
            420                 425                 430         


Cys Lys Asn Ile Lys His Cys Ala Asn Asp Ser Ser Ser Trp Val Pro 
        435                 440                 445             


Ile Pro Ala Asn Ser Thr Glu Ile Thr Leu Asp Ser His Ile Asp Glu 
    450                 455                 460                 


Asp Asn Asn Leu Glu Ser Gln Val Met Phe Gly His Leu Glu Ser Thr 
465                 470                 475                 480 


Met Ala Val Arg Cys Leu Ala Arg Asn Glu Met Ala Val Val Ser Arg 
                485                 490                 495     


Glu Val Lys Leu Val Ser Asn Gly Pro His Pro Glu Leu Thr Val Ala 
            500                 505                 510         


Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
        515                 520                 525             


Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 
    530                 535                 540                 


Val Ile Glu Ser Val Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 
545                 550                 555                 560 


Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Arg 
                565                 570                 575     


Leu Val Leu Gly Arg Ile Leu Gly Ser Gly Ala Phe Gly Lys Val Val 
            580                 585                 590         


Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 
        595                 600                 605             


Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 
    610                 615                 620                 


Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 
625                 630                 635                 640 


Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 
                645                 650                 655     


Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 
            660                 665                 670         


Asn Arg Glu Asn Phe Leu Ser Leu Asn Pro Glu Lys Asn Lys Lys Glu 
        675                 680                 685             


Leu Asp Ile Phe Gly Ile Asn Pro Ala Asp Glu Ser Ser Arg Ser Tyr 
    690                 695                 700                 


Val Ile Leu Ser Phe Glu Ser Lys Gly Asp Tyr Met Asp Met Lys Gln 
705                 710                 715                 720 


Ala Asp Ser Thr Gln Tyr Val Pro Met Leu Glu Met Ser Asn Ala Ser 
                725                 730                 735     


Lys Tyr Ser Asp Ile Gln Arg Ser Asn Tyr Asp His Pro Pro Ser Gln 
            740                 745                 750         


Lys Gly Ser Ser Glu Met Glu Ile Met Leu Ser Asp Asp Val Asn Glu 
        755                 760                 765             


Gly Leu Thr Thr Thr Asp Leu Leu Ser Phe Thr Tyr Gln Val Ala Lys 
    770                 775                 780                 


Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala 
785                 790                 795                 800 


Ala Arg Asn Val Leu Leu Ser Gln Gly Lys Ile Val Lys Ile Cys Asp 
                805                 810                 815     


Phe Gly Leu Ala Arg Asp Ile Met His Asp Asn Asn Tyr Val Ser Lys 
            820                 825                 830         


Gly Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe 
        835                 840                 845             


Asp Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser Tyr Gly Ile Leu 
    850                 855                 860                 


Leu Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr Pro Gly Met Val 
865                 870                 875                 880 


Val Asp Ser Ser Phe Tyr Asn Lys Ile Lys Ser Gly Tyr Arg Met Ser 
                885                 890                 895     


Lys Pro Glu His Ala Pro His Asp Val Tyr Glu Met Met Met Lys Cys 
            900                 905                 910         


Trp Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Leu Gly Leu Ser Glu 
        915                 920                 925             


Thr Val Ala Ser Leu Leu Pro Ser Ser Tyr Lys Arg Gln Tyr Glu Arg 
    930                 935                 940                 


Val Asn His Glu Phe Leu Lys Ser Asp His Pro Ala Val Thr Arg Val 
945                 950                 955                 960 


Cys Met Glu Asn Glu Asp Tyr Ile Gly Ile Ala Tyr Lys Asn Gln Gly 
                965                 970                 975     


Lys Leu Lys Asp Arg Glu Ser Gly Phe Asp Glu Gln Arg Leu Ser Ser 
            980                 985                 990         


Asp Ser Gly Tyr Ile Ile Pro Leu  Pro Asp Leu Asp Pro  Ile Ser Asp 
        995                 1000                 1005             


Glu Glu  Tyr Gly Lys Arg Asn  Arg His Ser Ser Gln  Thr Ser Glu 
    1010                 1015                 1020             


Glu Ser  Ala Ile Glu Thr Gly  Ser Ser Ser Ser Thr  Phe Ala Lys 
    1025                 1030                 1035             


Arg Glu  Gly Glu Thr Leu Glu  Asp Ile Thr Leu Leu  Asp Glu Met 
    1040                 1045                 1050             


Cys Leu  Asp Cys Ser Asp Leu  Val Glu Asp Ser Phe  Leu 
    1055                 1060                 1065     


<210>  26
<211>  1107
<212>  PRT
<213>  Bos taurus

<400>  26

Met Lys Asp Thr Met Trp Leu Pro Ser Ala Met Gln Ala Val Val Leu 
1               5                   10                  15      


Lys Gly Arg Val Leu Leu Leu Pro Leu Leu Phe Leu Leu Gly Pro Gln 
            20                  25                  30          


Ala Ser Trp Gly Leu Ala Ile Ile Pro Pro Gly Pro Glu Leu Val Leu 
        35                  40                  45              


Asn Leu Ser Ser Thr Phe Val Leu Thr Cys Ser Gly Pro Ala Pro Val 
    50                  55                  60                  


Val Trp Glu Arg Met Ser Gln Lys Pro Pro Gln Glu Met Thr Glu Thr 
65                  70                  75                  80  


Gln Asp Gly Thr Phe Ser Ser Val Leu Thr Leu Val Asn Val Thr Gly 
                85                  90                  95      


Leu Asp Thr Gly Glu Tyr Phe Cys Gly Tyr Lys Arg Ser His Gly Leu 
            100                 105                 110         


Glu Ala Ser Glu Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Ser 
        115                 120                 125             


Val Gly Phe Leu Pro Val Asp Pro Glu Glu Leu Phe Ile Phe Leu Thr 
    130                 135                 140                 


Glu Ile Thr Glu Thr Thr Ile Pro Cys Arg Val Thr Asp Pro Arg Leu 
145                 150                 155                 160 


Val Val Met Leu His Glu Lys Lys Val Asp Val Pro Leu Pro Ile Ala 
                165                 170                 175     


Tyr Asp Pro Gln Arg Gly Phe Ser Gly Thr Phe Glu Asp Lys Thr Tyr 
            180                 185                 190         


Ile Cys Lys Thr Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr 
        195                 200                 205             


His Val Tyr Ser Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala 
    210                 215                 220                 


Val Gln Thr Val Val Arg Gln Gly Glu Asn Ile Thr Ile Met Cys Ile 
225                 230                 235                 240 


Val Thr Gly Asn Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Met 
                245                 250                 255     


Glu Ser Gly Arg Leu Val Glu Pro Val Thr Asp Phe Leu Phe Glu Met 
            260                 265                 270         


Pro His Ile Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Gly Asp 
        275                 280                 285             


Ser Gly Thr Tyr Ile Cys Asn Val Ser Glu Ser Val Ser Asp His Arg 
    290                 295                 300                 


Asp Glu Lys Ala Ile Asn Val Thr Val Val Glu Asn Gly Tyr Val Arg 
305                 310                 315                 320 


Leu Leu Gly Glu Leu Asp Pro Val Gln Phe Ala Glu Leu His Arg Ser 
                325                 330                 335     


Arg Thr Leu Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Met 
            340                 345                 350         


Trp Phe Lys Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile 
        355                 360                 365             


Val Leu Ser Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu 
    370                 375                 380                 


Thr Leu Val Arg Val Lys Val Ala Glu Ala Gly Tyr Tyr Thr Met Arg 
385                 390                 395                 400 


Ala Phe His Glu Asp Ala Glu Ala Gln Leu Ser Phe Gln Leu Gln Val 
                405                 410                 415     


Asn Val Pro Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Ala Asn 
            420                 425                 430         


Gly Glu Gln Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro His 
        435                 440                 445             


Leu Thr Trp Ser Thr Cys Ser Asp Leu Lys Arg Cys Pro Arg Glu Leu 
    450                 455                 460                 


Pro Pro Thr Pro Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu 
465                 470                 475                 480 


Thr Asn Val Thr Tyr Trp Ala Glu Glu Gln Glu Phe Glu Val Val Ser 
                485                 490                 495     


Thr Leu Arg Leu Arg His Val Asp Gln Pro Leu Ser Val Arg Cys Thr 
            500                 505                 510         


Leu His Asn Leu Leu Gly Tyr Asp Val Gln Glu Val Thr Val Val Pro 
        515                 520                 525             


His Ser Leu Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu 
    530                 535                 540                 


Val Val Leu Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln 
545                 550                 555                 560 


Lys Lys Pro Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser 
                565                 570                 575     


Ser Asp Gly His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr 
            580                 585                 590         


Asp Ser Thr Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr 
        595                 600                 605             


Leu Gly Ser Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly 
    610                 615                 620                 


Leu Ser His Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys 
625                 630                 635                 640 


Ser Thr Ala Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys 
                645                 650                 655     


Ile Met Ser His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly 
            660                 665                 670         


Ala Cys Thr Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg 
        675                 680                 685             


Tyr Gly Asp Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu 
    690                 695                 700                 


Gln Arg Cys Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser 
705                 710                 715                 720 


Asn Ala Leu Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Pro 
                725                 730                 735     


Gly Glu Ser Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val 
            740                 745                 750         


Asp Tyr Val Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp 
        755                 760                 765             


Ile Glu Ser Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser 
    770                 775                 780                 


Ala Pro Glu Arg Thr Cys Arg Val Thr Leu Ile Asn Glu Ser Pro Val 
785                 790                 795                 800 


Leu Ser Tyr Thr Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly 
                805                 810                 815     


Met Glu Phe Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala 
            820                 825                 830         


Arg Asn Val Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe 
        835                 840                 845             


Gly Leu Ala Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly 
    850                 855                 860                 


Ser Thr Phe Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn 
865                 870                 875                 880 


Ser Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu 
                885                 890                 895     


Trp Glu Ile Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met 
            900                 905                 910         


Asn Glu Gln Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln 
        915                 920                 925             


Pro Ala His Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp 
    930                 935                 940                 


Glu Glu Lys Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu 
945                 950                 955                 960 


Leu Glu Arg Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val 
                965                 970                 975     


Asp Glu Glu Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln 
            980                 985                 990         


Ala Arg Leu Pro Gly Phe Asn Gly  Leu Arg Ser Pro Leu  Asp Ser Ser 
        995                 1000                 1005             


Ser Val  Leu Tyr Thr Ala Val  Gln Pro Asn Glu Gly  Asp Asn Asp 
    1010                 1015                 1020             


Tyr Ile  Ile Pro Leu Pro Asp  Pro Lys Pro Glu Val  Ala Asp Glu 
    1025                 1030                 1035             


Gly Pro  Leu Glu Gly Ser Pro  Ser Leu Ala Ser Ser  Thr Leu Asn 
    1040                 1045                 1050             


Glu Val  Asn Thr Ser Ser Thr  Ile Ser Cys Asp Ser  Pro Leu Glu 
    1055                 1060                 1065             


Pro Gln  Glu Glu Pro Glu Pro  Glu Pro Gln Pro Ala  Ser Gln Val 
    1070                 1075                 1080             


Glu Pro  Glu Pro Lys Trp Pro  Pro Asp Ser Ser Cys  Pro Gly Pro 
    1085                 1090                 1095             


Arg Ala  Glu Ala Glu Asp Ser  Phe Leu 
    1100                 1105         


<210>  27
<211>  295
<212>  PRT
<213>  Bos taurus

<400>  27

Gly Pro Pro Pro Trp Pro Leu Lys His Pro Ala Leu Ser Ser Pro Arg 
1               5                   10                  15      


Gln Glu Glu Gly Pro Ala His Ser Cys Pro Ala Gln Leu Arg Pro Leu 
            20                  25                  30          


Leu Pro Ser Pro Ser Pro Pro Pro Ser Asn Lys Leu Ser Pro Lys Ser 
        35                  40                  45              


Ser Arg Gly Arg Arg Ser Glu Pro Glu Thr Ser Pro Pro Ile Gly Pro 
    50                  55                  60                  


Gln Gly Cys Leu Gln Gly Pro Asp Thr Pro Ser Leu Arg Ser Leu Ser 
65                  70                  75                  80  


Thr Leu Gln Thr Thr Cys Cys Pro Pro Gln Val Pro Phe Ala Thr Arg 
                85                  90                  95      


Pro Ser Glu Gln Arg Glu Asp Pro Gln Ala Asp Ser Ser Ala Ser Pro 
            100                 105                 110         


Leu Pro His Leu Glu Ala Lys Ile Gln Gln Thr His Ser Leu Ala Arg 
        115                 120                 125             


Leu Leu Thr Lys Tyr Ala Glu Gln Leu Leu Gln Glu Tyr Val Gln His 
    130                 135                 140                 


Gln Gly Asp Pro Phe Gly Leu Pro Gly Phe Ser Pro Pro Arg Leu Pro 
145                 150                 155                 160 


Val Ala Asp Leu Ser Asp Pro Ala Pro Gly His Ala Gly Leu Pro Val 
                165                 170                 175     


Pro Glu Arg Leu Arg Leu Asp Ala Ala Ala Leu Ala Ala Leu Pro Pro 
            180                 185                 190         


Leu Leu Asp Val Val Arg Arg Leu Gln Gly Glu Leu Asn Pro Arg Ala 
        195                 200                 205             


Leu Arg Leu Leu Arg Arg Leu Glu Asp Ala Ala Arg Gln Val Arg Ala 
    210                 215                 220                 


Leu Gly Ala Ala Val Glu Ala Val Leu Ala Ala Leu Gly Ala Glu Ser 
225                 230                 235                 240 


Arg Gly Pro Arg Pro Glu Pro Ala Ala Ala Ala Val Ala Ala Ser Thr 
                245                 250                 255     


Ala Ser Ala Gly Val Phe Pro Ala Lys Val Leu Gly Phe Arg Val Cys 
            260                 265                 270         


Gly Leu Tyr Leu Glu Trp Val Ser Arg Thr Glu Ala Asp Leu Gly Gln 
        275                 280                 285             


Leu Ala Pro Gly Gly Pro Ala 
    290                 295 


<210>  28
<211>  1095
<212>  PRT
<213>  Bos taurus

<400>  28

Met Met Asp Ile Ser Leu Cys Val Lys Arg Pro Ser Trp Leu Val Asp 
1               5                   10                  15      


Arg Lys Arg Met Arg Met Ala Ser Asn Ser Gln Trp Leu Leu Leu Thr 
            20                  25                  30          


Ala Val Leu Leu Tyr Leu Thr Asn Gln Val Asn Ser Gln Lys Lys Ser 
        35                  40                  45              


Thr Pro His Asp Leu Lys Cys Val Thr Asn Asn Leu Lys Val Trp Asp 
    50                  55                  60                  


Cys Ser Trp Arg Ala Leu Phe Gly Ala Gly Arg Ala Ala Ser Tyr Glu 
65                  70                  75                  80  


Val Cys Ile Glu Lys Arg Ser Arg Thr Cys Tyr Leu Leu Glu Lys Asn 
                85                  90                  95      


Thr Thr Ile Pro Pro Leu Leu Pro Gly His Tyr Glu Ile Thr Val His 
            100                 105                 110         


Pro Leu Tyr Glu Phe Gly Ser Ser Lys Ser Lys Phe Ile Leu Asn Glu 
        115                 120                 125             


Lys Asn Ile Ser Leu Ile Pro Glu Thr Pro Glu Ile Leu Asn Leu Ser 
    130                 135                 140                 


Ala Asp Phe Ser Thr Ser Thr Leu His Leu Lys Trp Asn Asp Lys Gly 
145                 150                 155                 160 


Ser Val Phe Pro His Tyr Ser Asn Val Ile Trp Glu Ile Lys Val Leu 
                165                 170                 175     


His Lys Lys Asn Met Glu Ile Val Lys Leu Val Thr Tyr Ser Thr Thr 
            180                 185                 190         


Leu Asn Gly Arg Asp Thr Ile His His Trp Asn Trp Thr Ser Asp Met 
        195                 200                 205             


Pro Leu Glu Cys Ala Ile His Tyr Val Gly Ile Arg Cys Tyr Ile Asp 
    210                 215                 220                 


Asp Pro Gln Phe Ser Gly His Lys Glu Trp Ser Asp Trp Ser Leu Leu 
225                 230                 235                 240 


Lys Asn Ile Ser Leu Pro Pro Asp Ser Gln Thr Lys Val Phe Pro Gln 
                245                 250                 255     


Asp Lys Val Ile Leu Ala Gly Ser Asp Ile Thr Val Cys Cys Val Thr 
            260                 265                 270         


Gln Glu Lys Val Leu Ser Ala Gln Ile Gly Ser Thr His Cys Pro Leu 
        275                 280                 285             


Ile His Leu Asp Gly Glu Asn Val Ala Ile Arg Ile Arg Asn Ile Ser 
    290                 295                 300                 


Ala Ser Ala Ser Ser Gly Thr Asn Val Val Phe Ser Val Glu Asp Asn 
305                 310                 315                 320 


Ile Phe Gly Thr Val Val Phe Ala Gly Tyr Pro Pro Asp Ile Pro Gln 
                325                 330                 335     


Lys Leu Asn Cys Glu Thr Tyr Asp Leu Lys Glu Ile Ile Cys Thr Trp 
            340                 345                 350         


Asn Pro Gly Arg Pro Thr Ser Leu Glu Gly Pro Arg Ser Thr Ser Tyr 
        355                 360                 365             


Thr Leu Phe Glu Ser Phe Ser Gly Lys Tyr Val Arg Phe Lys Gly Asp 
    370                 375                 380                 


Glu Val Ser Ala Asn Glu Asn Tyr Gln Leu Phe Leu Gln Ile Leu Ser 
385                 390                 395                 400 


Ser Gln Glu Ile His Asn Phe Thr Leu Asn Ala Gln Asn Leu Leu Gly 
                405                 410                 415     


Gln Thr Glu Ser Thr Leu Leu Val Asn Ile Thr Glu Lys Val His Pro 
            420                 425                 430         


Arg Ile Pro Thr Ser Leu Lys Ala Lys Asp Ile Asn Ser Thr Ala Val 
        435                 440                 445             


Ile Leu Ser Trp His Leu Pro Gly Asn Phe Thr Lys Val Lys Leu Leu 
    450                 455                 460                 


Cys Gln Ile Glu Ile Asn Lys Thr Asn Ser Glu His Glu Leu Arg Asn 
465                 470                 475                 480 


Val Thr Met Arg Gly Val Glu Ser Ser Asn Tyr Leu Thr Thr Val Asp 
                485                 490                 495     


Lys Leu Asn Pro Tyr Thr Ile Tyr Thr Phe Arg Ile Arg Cys Ser Thr 
            500                 505                 510         


Asp Pro Phe Trp Lys Trp Ser Lys Trp Ser Asn Glu Lys Gln Cys Leu 
        515                 520                 525             


Thr Thr Glu Ala Ile Pro Ser Lys Gly Pro Asp Ile Trp Arg Glu Trp 
    530                 535                 540                 


Ser Ser Asp Gly Arg Asn Leu Ile Ile Tyr Trp Lys Pro Leu Pro Ile 
545                 550                 555                 560 


Asn Glu Ala Tyr Gly Lys Ile Leu Ser Tyr Asn Val Ser Tyr Ser Ser 
                565                 570                 575     


Asp Glu Glu Thr Lys Ser Leu Ser Glu Ile Pro Asp Thr Gln His Arg 
            580                 585                 590         


Ala Glu Leu Gln Leu Asp Lys Asn Asp Tyr Ile Ile Ser Val Val Ala 
        595                 600                 605             


Lys Asn Ser Ala Gly Ser Ser Pro Pro Ser Lys Ile Ala Ser Met Glu 
    610                 615                 620                 


Ile Pro Asn Asp Asp Leu Lys Ile Glu Gln Ala Leu Gly Met Gly Asn 
625                 630                 635                 640 


Arg Ile Leu Leu Thr Trp Asn Tyr Asp Pro Asn Met Thr Cys Asp Tyr 
                645                 650                 655     


Val Ile Lys Trp Cys Asn Ser Ser Gln Ser Gly Pro Cys Leu Met Asp 
            660                 665                 670         


Trp Lys Lys Val Pro Pro Asn Ser Thr Glu Thr Val Ile Glu Ser Asp 
        675                 680                 685             


Gln Phe Arg Pro Gly Val Arg Tyr Asn Phe Ser Val Tyr Gly Cys Arg 
    690                 695                 700                 


Asn Gln Gly Tyr Gln Leu Leu Arg Ser Val Ile Gly Tyr Val Glu Glu 
705                 710                 715                 720 


Leu Ala Pro Ala Val Ala Pro Asn Phe Thr Val Glu Asp Thr Ser Ala 
                725                 730                 735     


Asp Ser Ile Leu Val Lys Trp Glu Glu Ile Pro Val Glu Glu Leu Arg 
            740                 745                 750         


Gly Phe Leu Arg Gly Tyr Leu Phe Tyr Phe Glu Lys Gly Glu Arg Asp 
        755                 760                 765             


Thr Ser Lys Ile Met Gly Leu Glu Pro Gly Arg Phe Asp Thr Lys Val 
    770                 775                 780                 


Lys Asn Ile Thr Asp Ile Ser Gln Lys Thr Leu Arg Ile Ala Asp Leu 
785                 790                 795                 800 


Gln Gly Lys Thr Ser Tyr His Leu Val Leu Arg Ala Tyr Thr Gly Gly 
                805                 810                 815     


Gly Met Gly Pro Glu Arg Ser Met Phe Val Val Thr Lys Glu Asn Ser 
            820                 825                 830         


Glu Gly Leu Ile Ile Ala Ile Leu Ile Pro Val Ala Val Ala Val Ile 
        835                 840                 845             


Ile Gly Val Val Thr Ser Ile Leu Cys Tyr Arg Lys Arg Glu Trp Ile 
    850                 855                 860                 


Lys Glu Thr Phe Tyr Pro Asp Ile Pro Asn Pro Glu Asn Cys Lys Ala 
865                 870                 875                 880 


Leu Gln Phe Gln Lys Ser Val Cys Glu Gly Asn Ser Ala Leu Lys Thr 
                885                 890                 895     


Leu Glu Met Asn Pro Cys Thr Pro Asn Asn Val Glu Val Leu Glu Thr 
            900                 905                 910         


Arg Ser Val Ala Leu Lys Ile Glu Asp Thr Glu Ile Ile Ser Pro Val 
        915                 920                 925             


Ala Glu Arg Pro Glu Asp Arg Ser Asp Ala Glu Pro Glu Asn His Val 
    930                 935                 940                 


Val Val Ser Tyr Cys Pro Pro Val Ile Glu Glu Glu Leu Ala Asn Pro 
945                 950                 955                 960 


Gly Ala Glu Gly Gly Gly Ala Ser Gln Val Ile Tyr Ile Asp Val Gln 
                965                 970                 975     


Ser Met Tyr Gln Pro Gln Ala Lys Pro Glu Gly Glu Leu Asp Ser Asp 
            980                 985                 990         


Pro Val Gly Gly Ala Gly Tyr Lys  Pro Gln Met His Leu  Pro Val Thr 
        995                 1000                 1005             


Ser Thr  Val Asp Asp Leu Asp  Ala Asp Asp Asp Leu  Asp Lys Thr 
    1010                 1015                 1020             


Ala Gly  Tyr Arg Pro Gln Ala  Asn Val Asn Thr Trp  Asn Leu Val 
    1025                 1030                 1035             


Ser Pro  Asp Ser Pro Arg Ser  Thr Asp Ser Asn Ser  Glu Ile Val 
    1040                 1045                 1050             


Ser Phe  Gly Ser Pro Cys Ser  Ile Asn Ser Arg Gln  Phe Leu Ile 
    1055                 1060                 1065             


Pro Pro  Lys Asp Glu Asp Ser  Pro Lys Ser Ser Gly  Gly Gly Trp 
    1070                 1075                 1080             


Ser Phe  Thr Asn Phe Phe Gln  Asn Lys Pro Asn Asp  
    1085                 1090                 1095 


<210>  29
<211>  730
<212>  PRT
<213>  Bos taurus

<400>  29

Met Trp Val Thr Arg Leu Leu Pro Val Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Lys Lys Arg Arg Asn Thr Leu His Glu Phe Lys Arg Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Glu Asp Pro Leu Leu Lys Ile Lys Thr Lys Lys Met 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Ile Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Arg Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Gly Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Asn Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Pro Met Asp 
    210                 215                 220                 


His Thr Glu Thr Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Lys Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro Asp Thr Pro Trp Glu Tyr Cys Ala Ile Lys Met Cys 
        275                 280                 285             


Ala His Ser Thr Met Asn Asp Thr Asp Leu Pro Met Gln Thr Thr Glu 
    290                 295                 300                 


Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Ile Asn Thr Ile 
305                 310                 315                 320 


Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Gln 
                325                 330                 335     


His Asp Ile Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn 
            340                 345                 350         


Tyr Cys Arg Asn Pro Asp Gly Ala Glu Ser Pro Trp Cys Phe Thr Thr 
        355                 360                 365             


Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Lys Cys Asp 
    370                 375                 380                 


Val Ser Ser Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met 
385                 390                 395                 400 


Gly Ser Leu Ser Lys Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp 
                405                 410                 415     


Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala 
            420                 425                 430         


Thr Lys Leu Asn Lys Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His 
        435                 440                 445             


Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys 
    450                 455                 460                 


Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu 
465                 470                 475                 480 


Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val 
                485                 490                 495     


Asn Gly Ile Pro Thr Arg Thr Asn Val Gly Trp Met Val Ser Leu Lys 
            500                 505                 510         


Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp 
        515                 520                 525             


Ile Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asn Lys Asp Leu Lys 
    530                 535                 540                 


Asp Tyr Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp 
545                 550                 555                 560 


Glu Lys Arg Lys Gln Val Leu Asn Val Thr Gln Leu Val Tyr Gly Pro 
                565                 570                 575     


Glu Gly Ser Asp Leu Val Leu Leu Lys Leu Ala Arg Pro Ala Ile Leu 
            580                 585                 590         


Asp Asp Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile 
        595                 600                 605             


Pro Glu Lys Thr Thr Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu 
    610                 615                 620                 


Ile Asn Ser Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly 
625                 630                 635                 640 


Asn Glu Lys Cys Ser Gln Tyr His Gln Gly Lys Val Thr Leu Asn Glu 
                645                 650                 655     


Ser Glu Ile Cys Ala Gly Ala Glu Asn Ile Val Ser Gly Pro Cys Glu 
            660                 665                 670         


Gly Asp Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met 
        675                 680                 685             


Val Leu Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg 
    690                 695                 700                 


Pro Gly Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys 
705                 710                 715                 720 


Ile Ile Leu Thr Tyr Lys Ala Pro Gln Ser 
                725                 730 


<210>  30
<211>  711
<212>  PRT
<213>  Oreochromis niloticus

<400>  30

Met Trp Ile Tyr Lys Leu Val Phe Gly Phe Val Phe Val Val Ser Cys 
1               5                   10                  15      


Ser Glu Gly Arg Arg Asn Ala Leu Gln Asp Tyr Gln Lys Thr Asp Ser 
            20                  25                  30          


Ile Gln Leu Met Val His Ser Asp Ser Ser His Leu Thr Lys Ser Arg 
        35                  40                  45              


Lys Leu Ser Leu Ser Lys Cys Ala Lys Ala Cys Ser Arg Asn Lys Arg 
    50                  55                  60                  


Leu Pro Phe Thr Cys Arg Ala Phe Val Tyr Asp His Lys Asn Arg Lys 
65                  70                  75                  80  


Cys Gln Trp Leu Ser Phe Asp Arg Asn Ser Pro Gly Val Gln Ser Gln 
                85                  90                  95      


Gln Asn Met Asn Tyr Gln Leu Tyr Glu Lys Lys Asp Tyr Val Arg Glu 
            100                 105                 110         


Cys Ile Val Gly Thr Gly Gln Ser Tyr Arg Gly Arg Arg Ser Val Thr 
        115                 120                 125             


Val Ser Gly Ile Leu Cys Gln Ala Trp Ala Ser Pro Val Pro His Glu 
    130                 135                 140                 


His Lys Phe Met Ser Lys Arg Phe Arg Lys Thr Asp Leu Arg Glu Asn 
145                 150                 155                 160 


Tyr Cys Arg Asn Pro Asp Asn Ser Ala Val Gly Pro Trp Cys Phe Thr 
                165                 170                 175     


Thr Asp Pro Arg Pro His Phe Arg His Glu Glu Cys Gly Ile Pro Gln 
            180                 185                 190         


Cys Ser Glu Val Glu Cys Ile Asn Cys Ile Gly Glu Asp Tyr Arg Gly 
        195                 200                 205             


Pro Met Asp His Thr Glu Ser Gly Lys Glu Cys Gln Arg Trp Asp Leu 
    210                 215                 220                 


Asp Asp Pro His Lys His Leu Tyr His Pro Lys Arg Tyr Pro Asp Lys 
225                 230                 235                 240 


Gly Leu Asp Asp Asn Tyr Cys Arg Asn Pro Asp Gly Arg Gln Arg Pro 
                245                 250                 255     


Trp Cys Phe Thr Thr Asp Pro Asn Thr Pro Trp Glu Tyr Cys Asn Ile 
            260                 265                 270         


Thr Val Cys Glu Thr Pro Pro Lys Ser Asn Val Val Glu Thr Thr Glu 
        275                 280                 285             


Cys Tyr Gln Gly Arg Gly Glu Gly Tyr Arg Gly Thr Val Asp Met Thr 
    290                 295                 300                 


Pro Thr Gly Leu Thr Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Asn 
305                 310                 315                 320 


His Thr Phe Leu Pro Glu Ala Tyr Pro Cys Lys Asp Leu Arg Glu Asn 
                325                 330                 335     


Phe Cys Arg Asn Pro Asp Gly Gln Glu Phe Pro Trp Cys Phe Thr Thr 
            340                 345                 350         


Asp Pro Arg Val Arg Thr Met Ser Cys Ile Asn Ile Pro Gln Cys Gly 
        355                 360                 365             


Thr Gln Asn Arg Pro Val Ser Asp Cys Tyr Glu Arg Phe Gly Glu Asn 
    370                 375                 380                 


Tyr Gln Gly Gln Gln Ser Arg Thr Arg Ser Asn Leu Pro Cys Ala Pro 
385                 390                 395                 400 


Trp Arg Asp His Ser Asn Ser Gly Glu Arg Gly Met Pro Thr Ala Gly 
                405                 410                 415     


Leu Glu Gly Asn Tyr Cys Arg Asn Pro Asp Lys Asp Lys His Gly Pro 
            420                 425                 430         


Trp Cys Tyr Thr Asn Asn Ser Ala Ile Pro Trp Asp Tyr Cys Asn Val 
        435                 440                 445             


Lys Pro Cys Asn Ala Ser Gln Asn Thr Ile Gln Leu Gly Glu Asp Ala 
    450                 455                 460                 


Ser Val Ser Cys Phe Val His Lys Thr Thr Arg Ile Val Gly Gly Ser 
465                 470                 475                 480 


Pro Val Ser Ile Ser Glu Gly Ser Trp Met Val Ser Ile Gln Lys Gly 
                485                 490                 495     


Ser Met His Trp Cys Gly Gly Ser Leu Ile Arg Asp Glu Trp Val Leu 
            500                 505                 510         


Thr Asp Arg Glu Cys Phe Ser Ser Cys Val Pro Asn Leu Ser Glu Tyr 
        515                 520                 525             


Arg Val Trp Leu Gly Val Ser Asp Ile Arg Glu Gly Ala Pro Asp Trp 
    530                 535                 540                 


Ser Lys Arg Gln Glu Val Ser Ile Ala His Val Ile Cys Gly Pro Glu 
545                 550                 555                 560 


Gly Ser Ser Leu Ala Leu Leu Arg Leu Ser Lys Pro Ala Leu Pro Ala 
                565                 570                 575     


Asp Asn Val His Thr Ile Gln Leu Pro Val Ala Gly Cys Thr Ile Pro 
            580                 585                 590         


Glu Gly Thr Ile Cys Lys Met Tyr Gly Trp Gly Glu Thr Lys Gly Thr 
        595                 600                 605             


Gly Tyr Glu Asp Met Leu Lys Ala Val Glu Leu Pro Ile Val Arg Asn 
    610                 615                 620                 


Asn Arg Cys Arg Glu Met His Arg Gly Asn Leu His Ile Thr Thr Asn 
625                 630                 635                 640 


Lys Ile Cys Ala Gly Gly Lys Arg Asn Glu Gly Val Cys Glu Arg Asp 
                645                 650                 655     


Tyr Gly Gly Pro Leu Val Cys Gln Asp Gly Tyr Ile Arg Val Ile Val 
            660                 665                 670         


Gly Val Ser Val His Gly Arg Gly Cys Ala Arg Ala Asn Gln Pro Ser 
        675                 680                 685             


Ile Phe Ile Asn Val Pro Phe Tyr Thr Gln Trp Ile Tyr Lys Val Phe 
    690                 695                 700                 


Lys Tyr Tyr Pro Asn Thr Val 
705                 710     


<210>  31
<211>  1384
<212>  PRT
<213>  Bos taurus

<400>  31

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Phe Val Gln Lys Ser Asn Gly Glu Cys Lys Glu Ala Leu Val Lys 
            20                  25                  30          


Ser Arg Met Asn Val Asn Met Gln Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Ser Ile Gln Asn Val Val Leu His Lys His His Ile Tyr Leu 
    50                  55                  60                  


Gly Ala Ile Asn Tyr Ile Tyr Val Leu Asn Asp Lys Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser His Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Leu Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val His Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Leu Pro Pro Asn Asn Thr Ala Asp Ile Glu Ser Glu Val His Cys 
145                 150                 155                 160 


Met Tyr Ser Pro Gln Ala Asp Glu Glu Thr Asn Gln Cys Pro Asp Cys 
                165                 170                 175     


Val Val Ser Ala Leu Gly Thr Lys Val Leu Leu Ser Glu Lys Asp Arg 
            180                 185                 190         


Phe Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Leu Pro 
        195                 200                 205             


Asp Tyr Ile Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Gln 
    210                 215                 220                 


Asp Gly Phe Lys Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro 
225                 230                 235                 240 


Glu Leu Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser 
                245                 250                 255     


Asn His Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala 
            260                 265                 270         


Gln Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ala Asp Ser Gly 
        275                 280                 285             


Leu His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys 
    290                 295                 300                 


Arg Arg Lys Arg Ser Thr Lys Gln Glu Val Phe Asn Ile Leu Gln Ala 
305                 310                 315                 320 


Ala Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala 
                325                 330                 335     


Ser Leu Asn Asp Asp Ile Leu Tyr Gly Val Phe Ala Gln Ser Lys Pro 
            340                 345                 350         


Asp Ser Ser Glu Pro Met Asn Arg Ser Ala Val Cys Ala Phe Pro Val 
        355                 360                 365             


Lys Tyr Val Asn Glu Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val 
    370                 375                 380                 


Arg Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn 
385                 390                 395                 400 


Arg Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Val Arg Asn Asp Glu 
                405                 410                 415     


Tyr Arg Thr Glu Phe Thr Thr Ala Leu Pro Arg Val Asp Leu Phe Thr 
            420                 425                 430         


Gly Gln Phe Asn Gln Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys 
        435                 440                 445             


Gly Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met 
    450                 455                 460                 


Gln Val Val Val Ser Arg Ser Gly Ser Leu Thr Pro His Val Asn Phe 
465                 470                 475                 480 


His Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Pro 
                485                 490                 495     


Leu Asn Gln Asn Gly Tyr Thr Leu Val Val Thr Gly Lys Lys Ile Thr 
            500                 505                 510         


Lys Ile Pro Leu Asn Gly Leu Gly Cys Glu His Phe Gln Ser Cys Ser 
        515                 520                 525             


Gln Cys Leu Ser Ala Pro Ser Phe Val Gln Cys Gly Trp Cys His Asp 
    530                 535                 540                 


Lys Cys Val Arg Leu Glu Glu Cys Ser Ser Gly Thr Trp Thr Gln Glu 
545                 550                 555                 560 


Thr Cys Leu Pro Thr Ile Tyr Lys Val Phe Pro Thr Ser Ala Pro Leu 
                565                 570                 575     


Glu Gly Gly Thr Thr Leu Thr Val Cys Gly Trp Asp Phe Gly Phe Lys 
            580                 585                 590         


Arg Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn 
        595                 600                 605             


Glu Ser Cys Thr Leu Thr Leu Thr Glu Ser Thr Thr Asn Met Leu Lys 
    610                 615                 620                 


Cys Thr Val Gly Pro Ala Met Asn Glu His Phe Asn Met Ser Ile Val 
625                 630                 635                 640 


Ile Ser Asn Ser Arg Gly Ser Val Glu Tyr Ser Ala Phe Ser Tyr Val 
                645                 650                 655     


Asp Pro Ile Ile Thr Ser Ile Ser Pro Asn Tyr Gly Pro Lys Thr Gly 
            660                 665                 670         


Gly Thr Leu Leu Thr Leu Thr Gly Lys His Leu Asn Ser Gly Asn Ser 
        675                 680                 685             


Arg His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser 
    690                 695                 700                 


His Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Ser Ala Pro Thr Glu 
705                 710                 715                 720 


Phe Ser Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Val Asn Ser 
                725                 730                 735     


Phe Ile Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys 
            740                 745                 750         


Ser Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu 
        755                 760                 765             


Asn Ser Val Ser Val Leu Arg Met Val Ile Asn Val His Glu Ala Gly 
    770                 775                 780                 


Arg Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile 
785                 790                 795                 800 


Cys Cys Thr Thr Pro Ser Ile Glu Gln Leu Asn Leu Gln Leu Pro Leu 
                805                 810                 815     


Lys Thr Lys Ala Phe Phe Met Leu Asp Gly Ile His Ser Lys Tyr Phe 
            820                 825                 830         


Asp Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro 
        835                 840                 845             


Val Met Ile Ser Val Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn 
    850                 855                 860                 


Asp Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn 
865                 870                 875                 880 


Lys Ser Cys Glu Asn Ile His Ser His Ser Glu Ala Val Leu Cys Thr 
                885                 890                 895     


Val Pro Ser Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp 
            900                 905                 910         


Lys Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro 
        915                 920                 925             


Asp Gln Asn Phe Thr Gly Leu Ile Val Gly Val Val Ser Ile Ser Ile 
    930                 935                 940                 


Ile Leu Leu Leu Leu Leu Gly Leu Phe Leu Trp Leu Lys Lys Arg Lys 
945                 950                 955                 960 


Gln Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val 
                965                 970                 975     


His Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro 
            980                 985                 990         


Thr Thr Glu Met Val Ser Asn Glu  Ser Val Asp Tyr Arg  Ala Thr Phe 
        995                 1000                 1005             


Pro Glu  Asp Gln Phe Pro Asn  Ala Ser Gln Asn Gly  Ser Cys Arg 
    1010                 1015                 1020             


Gln Val  Gln Tyr Pro Leu Thr  Asp Leu Ser Pro Ile  Leu Thr Ser 
    1025                 1030                 1035             


Gly Asp  Ser Asp Ile Ser Ser  Pro Leu Leu Gln Asn  Thr Ile His 
    1040                 1045                 1050             


Ile Asp  Leu Ser Ala Leu Asn  Pro Glu Leu Val Gln  Ala Val Gln 
    1055                 1060                 1065             


His Val  Val Ile Gly Pro Ser  Ser Leu Ile Val His  Phe Asn Glu 
    1070                 1075                 1080             


Val Ile  Gly Arg Gly His Phe  Gly Cys Val Tyr His  Gly Thr Leu 
    1085                 1090                 1095             


Leu Asp  Asn Asp Asp Lys Lys  Ile His Cys Ala Val  Lys Ser Leu 
    1100                 1105                 1110             


Asn Arg  Ile Thr Asp Ile Gly  Glu Val Ser Gln Phe  Leu Thr Glu 
    1115                 1120                 1125             


Gly Ile  Ile Met Lys Asp Phe  Ser His Pro Asn Val  Leu Ser Leu 
    1130                 1135                 1140             


Leu Gly  Ile Cys Leu Arg Ser  Glu Gly Ser Pro Leu  Val Val Leu 
    1145                 1150                 1155             


Pro Tyr  Met Lys His Gly Asp  Leu Arg Asn Phe Ile  Arg Asn Glu 
    1160                 1165                 1170             


Thr His  Asn Pro Thr Val Lys  Asp Leu Ile Gly Phe  Gly Leu Gln 
    1175                 1180                 1185             


Val Ala  Lys Gly Met Glu Tyr  Leu Ala Ser Lys Lys  Phe Val His 
    1190                 1195                 1200             


Arg Asp  Leu Ala Ala Arg Asn  Cys Met Leu Asp Glu  Lys Phe Thr 
    1205                 1210                 1215             


Val Lys  Val Ala Asp Phe Gly  Leu Ala Arg Asp Val  Tyr Asp Lys 
    1220                 1225                 1230             


Glu Tyr  Tyr Ser Val His Asn  Lys Thr Gly Ala Lys  Leu Pro Val 
    1235                 1240                 1245             


Lys Trp  Met Ala Leu Glu Ser  Leu Gln Thr Gln Lys  Phe Thr Thr 
    1250                 1255                 1260             


Lys Ser  Asp Val Trp Ser Phe  Gly Val Leu Leu Trp  Glu Leu Met 
    1265                 1270                 1275             


Thr Arg  Gly Ala Pro Pro Tyr  Pro Asp Val Asn Thr  Phe Asp Ile 
    1280                 1285                 1290             


Thr Val  Tyr Leu Leu Gln Gly  Arg Arg Leu Leu Gln  Pro Glu Tyr 
    1295                 1300                 1305             


Cys Pro  Asp Pro Leu Tyr Glu  Val Met Leu Lys Cys  Trp His Pro 
    1310                 1315                 1320             


Lys Ala  Glu Leu Arg Pro Ser  Phe Ser Glu Leu Val  Ser Arg Ile 
    1325                 1330                 1335             


Ser Val  Ile Phe Ser Thr Phe  Ile Gly Glu His Tyr  Val His Val 
    1340                 1345                 1350             


Asn Ala  Thr Tyr Val Asn Val  Lys Cys Val Ala Pro  Tyr Pro Ser 
    1355                 1360                 1365             


Leu Leu  Ser Ser Gln Asp Asn  Val Ser Gly Glu Asp  Asp Asp Asp 
    1370                 1375                 1380             


Thr 
    


<210>  32
<211>  1378
<212>  PRT
<213>  Oreochromis niloticus

<400>  32

Met Asn Leu Cys Leu Leu His Ala Ile Met Leu Leu Trp Ala Ile Arg 
1               5                   10                  15      


Ser Ser Val Gln Gly Gln Cys Asp Arg Ser Ser Glu Asp Thr Lys Leu 
            20                  25                  30          


Asn Leu Ser Val Thr Tyr Glu Leu Pro Ser Phe Thr Ala Glu Phe Pro 
        35                  40                  45              


Ile Gln Asn Met Val Ile Leu Asp Gly Val Ile Tyr Val Gly Ala Val 
    50                  55                  60                  


Asn Arg Ile Tyr Ala Leu Ala Pro Asn Leu Arg Lys Leu Ser Glu Tyr 
65                  70                  75                  80  


His Thr Gly Pro Leu Arg Ala Asn Glu Thr Cys Gly Gln Lys Leu Asn 
                85                  90                  95      


Gly Thr Ser Ser Ser Gly Arg Val Asp Asn His Asn Ile Ala Leu Val 
            100                 105                 110         


Ala Glu Asn Ile Tyr Asp Lys Gly Leu Tyr Ser Cys Gly Ser Ala Asp 
        115                 120                 125             


Asn Gly Val Cys Arg Arg His Val Leu Asp Asp Gly Val Ser Ala Lys 
    130                 135                 140                 


Ser Val Asp Glu Glu Val Tyr Cys Phe Ala Asp Lys Lys Lys Leu Glu 
145                 150                 155                 160 


Thr Gly Gln Pro Asp Asp Ser Asp Val Val Val Ser Pro Leu Gly Ser 
                165                 170                 175     


Gln Val Leu Asn Val Glu Ser Asn Val Ile Gln Phe Phe Val Gly Asn 
            180                 185                 190         


Ser Glu Ile Pro Gly Arg Arg Asn Ile Ser Ser Ser Ala Lys His Pro 
        195                 200                 205             


His Thr Leu Ser Leu Arg Lys Met Lys Thr Ser Gln Asn Gly Phe Thr 
    210                 215                 220                 


Phe Phe Ser Asn Arg Ser Tyr Met Asp Leu Ile Pro Ser Leu Arg Gly 
225                 230                 235                 240 


Asn Tyr Tyr Leu Arg Tyr Val Tyr Ser Phe Gln Ser Gly Pro Phe Thr 
                245                 250                 255     


Tyr Phe Leu Thr Val Gln Gln Val Ser Lys Asp Ser Gln Ala Tyr His 
            260                 265                 270         


Ser Arg Ile Val Arg Met Cys Ser Ala Asp Ser Val Ile Arg Arg Tyr 
        275                 280                 285             


Val Glu Met Pro Leu Glu Cys Ile Ser Thr Asp Lys Arg Arg Arg Arg 
    290                 295                 300                 


Arg Arg Ser Gly Thr Gly Val Lys Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Thr Lys Ala Gly Ile Asp Pro Glu Ile Gln Lys His Leu Lys 
                325                 330                 335     


Val Glu Glu Asp Asp Asp Val Leu Phe Ala Ala Phe Ala Lys Gly Lys 
            340                 345                 350         


Pro Asn Ser Lys Asp Pro Thr Pro Asn Ser Ala Val Cys Val Ile Ala 
        355                 360                 365             


Leu Lys Gln Ile Asn Ser Met Phe Lys Thr Tyr Met Glu Lys Cys Asn 
    370                 375                 380                 


Thr Ile Glu Pro Tyr His Phe Thr Gly Leu Asp Lys Lys Ser Cys Tyr 
385                 390                 395                 400 


Asn Val Thr Ser Ser Asp Asp Cys Asp Pro His Glu Gly Ile His Glu 
                405                 410                 415     


Gly Lys Glu Ser Thr Tyr Arg Leu Gln Val Thr Gln Phe Phe Gln Arg 
            420                 425                 430         


Leu Glu Tyr Trp His Lys Asp Leu Thr Asn Thr Leu Val Thr Ser Ile 
        435                 440                 445             


Thr Val Val Pro Val His Gly Arg Ala Val Val Tyr Leu Gly Thr Ala 
    450                 455                 460                 


Asp Gly Arg Gln Ile Gln Val Leu Leu Ser Arg Phe Ala Ser Pro His 
465                 470                 475                 480 


Val Asn Ile His Leu Asp Ser Arg Pro Val Thr Thr Ser Val Ala Leu 
                485                 490                 495     


Leu Asp Ala Asp Arg Ser Asp Gly Ala Ile Leu Met Ala Thr Gly Asn 
            500                 505                 510         


Lys Ile Thr Lys Val Pro Leu Ile Gly Pro Gly Cys Gly Gln Leu Thr 
        515                 520                 525             


Thr Cys Ile Ser Cys Leu Leu Ser Ser Arg Val Thr Glu Cys Gly Trp 
    530                 535                 540                 


Cys Asp Gly Arg Cys Thr Arg Ala Ser Glu Cys Thr Ser Ser Ile Trp 
545                 550                 555                 560 


Thr Gln Asp Tyr Cys Thr Pro Glu Ile Thr Lys Val Ser Pro Ala Ser 
                565                 570                 575     


Gly Pro Ile Arg Gly Ser Thr Val Val Thr Ile Cys Gly Lys Asn Phe 
            580                 585                 590         


Gly Phe Asp Lys Thr Glu Asn Phe Lys Ala Ser Met Val Thr Val Glu 
        595                 600                 605             


Val Ala Gly Ala Ser Cys Lys Leu Ser Arg Gln Glu Asn Ser Asn Arg 
    610                 615                 620                 


Trp Thr Glu Met His Cys Ser Pro Val Phe Asn Gly Asn Phe Thr Pro 
625                 630                 635                 640 


Ser Gly Asp Val Val Lys Val Thr Ser Gly Gln Asn Val Thr Met Phe 
                645                 650                 655     


Lys Gly Phe Asn Phe Val Asp Pro Val Ile Arg Asp Ile Phe Pro Thr 
            660                 665                 670         


Phe Gly Pro Lys Ser Gly Asn Thr Met Leu Thr Ile Thr Gly Ala Asn 
        675                 680                 685             


Leu Asp Thr Gly Ser Lys Arg Glu Val Thr Ile Gly Lys Gly Ile Cys 
    690                 695                 700                 


Asn Val Gln Ser Trp Ser Ser Lys Lys Val Thr Cys Lys Thr Pro Pro 
705                 710                 715                 720 


Tyr Ala Ala Leu Ser Ser Gln Thr Val Lys Leu Thr Val Asp Ser Val 
                725                 730                 735     


Glu Arg Arg Ala Pro Met Gln Phe Thr Tyr Asn Gln Asp Pro Ile Ile 
            740                 745                 750         


Asn Asn Ile Gln Pro Ser Arg Ser Phe Val Ser Gly Gly Cys Thr Val 
        755                 760                 765             


Ser Ala His Gly Leu Tyr Leu Lys Ser Gly Leu Gln Pro Met Met Leu 
    770                 775                 780                 


Val Ser Ile Gly Glu Asn Thr Glu Thr Phe His Val Ser Cys Val Tyr 
785                 790                 795                 800 


Gly Glu Asn Gln Thr Ser Ile Gln Cys Thr Thr Pro Ser Leu Val Lys 
                805                 810                 815     


Leu Gly Met Gln Pro Pro Val Ile Thr Lys Val Ser Phe Val Leu Asp 
            820                 825                 830         


Gly Tyr Ser Thr Lys Gln Met Asp Met Ile Tyr Val Glu Asp Pro Leu 
        835                 840                 845             


Phe Gln Asp Pro Lys Leu Thr Ser Lys Asp Asn Lys Ser Ile Val Glu 
    850                 855                 860                 


Leu Lys Gly Asp Arg Met Asp Arg Glu Ala Met Asn Cys Gln Val Leu 
865                 870                 875                 880 


Thr Val Ser Asn His Ser Cys Glu Ser Leu Thr Leu Val Gly Asn Thr 
                885                 890                 895     


Leu Glu Cys Ile Val Pro Thr Glu Leu Gln Val Ala Thr Ala Lys Glu 
            900                 905                 910         


Leu Gln Val Glu Trp Arg Gln Ala Asp Ser Ile Arg His Leu Gly Lys 
        915                 920                 925             


Val Thr Leu Ala Gln Glu Gln Asp Tyr Thr Gly Leu Ile Val Gly Cys 
    930                 935                 940                 


Val Cys Val Ser Leu Leu Leu Leu Leu Leu Gly Ser Leu Leu Met Trp 
945                 950                 955                 960 


Lys Lys Asn Lys His Ile Asp Asp Gln Gly Thr Asp Arg Pro Glu Thr 
                965                 970                 975     


Cys Arg Ala Pro Pro Pro Ile Tyr Gly Gly Asn Gly Glu Leu Leu Ser 
            980                 985                 990         


Pro Arg Leu Gly Ala Leu Gly Gly  Gly Ile Gly Met Gly  Leu Gly Met 
        995                 1000                 1005             


Gly Met  Gly Ile Asp Gly Asp  Leu Val Ser Pro Leu  Leu Met Ala 
    1010                 1015                 1020             


Pro Val  His Ile Asp Pro Ser  Cys Leu His Pro Asp  Leu Leu Thr 
    1025                 1030                 1035             


Glu Val  Gln His Val Val Ile  Ala Arg Glu Arg Leu  Leu Leu His 
    1040                 1045                 1050             


Leu Asn  Gln Val Ile Gly Arg  Gly His Phe Gly Cys  Val Phe His 
    1055                 1060                 1065             


Gly Thr  Leu Leu Glu Pro Asp  Gly Gln Lys Leu His  Cys Ala Val 
    1070                 1075                 1080             


Lys Ser  Leu Asn Arg Ile Thr  Asp Leu Glu Glu Val  Ser Gln Phe 
    1085                 1090                 1095             


Leu Lys  Glu Gly Ile Ile Met  Lys Asp Phe Ser His  Pro Asn Val 
    1100                 1105                 1110             


Leu Ser  Leu Leu Gly Ile Cys  Leu Pro Pro Glu Gly  Ser Pro Leu 
    1115                 1120                 1125             


Val Val  Leu Pro Tyr Met Lys  His Gly Asp Leu Arg  Asn Phe Ile 
    1130                 1135                 1140             


Arg Asp  Glu Gly His Asn Pro  Thr Val Lys Asp Leu  Met Gly Phe 
    1145                 1150                 1155             


Gly Leu  Gln Val Ala Arg Gly  Met Glu Tyr Leu Ala  Ser Lys Lys 
    1160                 1165                 1170             


Phe Val  His Arg Asp Leu Ala  Ala Arg Asn Cys Met  Leu Asp Glu 
    1175                 1180                 1185             


Ser Tyr  Thr Val Lys Val Ala  Asp Phe Gly Leu Ala  Arg Asp Val 
    1190                 1195                 1200             


Tyr Asp  Lys Glu Tyr Tyr Ser  Val His Asn Lys Ser  Gly Val Lys 
    1205                 1210                 1215             


Leu Pro  Val Lys Trp Met Ala  Leu Glu Ser Leu Gln  Thr His Lys 
    1220                 1225                 1230             


Phe Thr  Thr Lys Ser Asp Val  Trp Ser Phe Gly Val  Leu Leu Trp 
    1235                 1240                 1245             


Glu Leu  Met Thr Arg Gly Ala  Pro Pro Tyr Ser Asp  Val Asn Ser 
    1250                 1255                 1260             


Phe Asp  Ile Thr Val Phe Leu  Leu Gln Gly Arg Arg  Leu Leu Gln 
    1265                 1270                 1275             


Pro Glu  Phe Cys Pro Asp Ala  Leu Tyr Thr Val Met  Ile Glu Cys 
    1280                 1285                 1290             


Trp His  Pro Lys Pro Glu Arg  Arg Pro Ser Phe Ser  Glu Leu Val 
    1295                 1300                 1305             


Ser Arg  Ile Ser Ala Ile Phe  Ser Ser Phe Ser Gly  Glu His Tyr 
    1310                 1315                 1320             


Val Leu  Leu Asn Thr Thr Tyr  Val Asn Ile Asp Lys  Met Ser Pro 
    1325                 1330                 1335             


Tyr Pro  Ser Leu Leu Ser Ser  Thr Ala Ser Ser Ser  Ser Ser Ser 
    1340                 1345                 1350             


Ser Glu  Pro Ser Thr Ser Thr  Ser Leu Pro Ser Arg  Ser Pro Leu 
    1355                 1360                 1365             


Phe Cys  Gln Val Asp Arg Asp  Cys Cys Thr 
    1370                 1375             


<210>  33
<211>  142
<212>  PRT
<213>  Bos taurus

<400>  33

Ile Asp Glu Cys Arg Arg Gly Val His Ser Cys Gly Glu Asn Ala Thr 
1               5                   10                  15      


Cys Thr Asn Met Glu Gly Asn His Thr Cys Thr Cys Ala Gly Asp Leu 
            20                  25                  30          


Ser Glu Pro Gly Gln Ile Cys Pro Asp Ser Thr Leu Leu Ser His Leu 
        35                  40                  45              


Gly Lys Asn Gly His Asn Phe Leu Lys Lys Cys Phe Pro Glu Tyr Thr 
    50                  55                  60                  


Pro Asn Phe Glu Gly Tyr Cys Leu Asn Gly Arg Val Cys Ile Tyr Phe 
65                  70                  75                  80  


Gly Ile Ala Asn Leu Phe Ser Cys His Cys Pro Ile Gly Tyr Pro Gly 
                85                  90                  95      


Lys Arg Gly Glu Tyr Ile Asp Phe Asp Gly Trp Asp Pro His Ser Ala 
            100                 105                 110         


Gly Arg Gly His Gln Trp Asn Thr Ser Pro Val Ala Val Arg Ala Leu 
        115                 120                 125             


Val Leu Ala Phe Leu Leu Leu Leu Gly Leu Cys Arg Ala His 
    130                 135                 140         


<210>  34
<211>  116
<212>  PRT
<213>  Bos taurus

<400>  34

Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln Gly Thr Ser Asn Lys 
1               5                   10                  15      


Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe Leu Ser Leu Gln Arg 
            20                  25                  30          


Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn Leu Glu Ile Thr Tyr 
        35                  40                  45              


Met Gln Ser Ser Tyr Asn Leu Ser Phe Phe Lys Thr Ile Gln Glu Val 
    50                  55                  60                  


Ala Gly Tyr Ala Leu Ile Ala Leu Asn Thr Val Glu Lys Ile Pro Leu 
65                  70                  75                  80  


Glu Asn Leu Gln Ile Ile Arg Gly Asn Val Leu Tyr Glu Asn Thr His 
                85                  90                  95      


Ala Leu Ala Val Leu Ser Asn Tyr Gly Ala Asn Lys Thr Gly Leu Lys 
            100                 105                 110         


Glu Leu Pro Leu 
        115     


<210>  35
<211>  1206
<212>  PRT
<213>  Oreochromis niloticus

<400>  35

Met Thr Pro Ser His Arg Glu Leu Gln Asn Asn Thr Met Ala Ala Arg 
1               5                   10                  15      


Phe Leu Lys Trp Ile Ser Leu Thr Ser Leu Leu Trp Leu Ser Phe Cys 
            20                  25                  30          


Gly Leu Ala Glu Asn Lys Val Cys Gln Gly Val Thr Asn Arg Leu Asn 
        35                  40                  45              


Leu Leu Gly Thr Lys Glu Asp His Tyr Arg Asn Met Val Lys Thr Tyr 
    50                  55                  60                  


Ser Asn Cys Thr Val Val Leu Glu Asn Leu Glu Ile Thr Tyr Met Glu 
65                  70                  75                  80  


Asp His Arg Asp Leu Ser Phe Leu Arg Ser Ile Lys Glu Val Gly Gly 
                85                  90                  95      


Tyr Val Leu Ile Ala Leu Asn Thr Val Ser Arg Ile Pro Leu Glu Asn 
            100                 105                 110         


Leu Arg Ile Ile Arg Gly His Ser Leu Tyr Asp Gly Ser Phe Ala Leu 
        115                 120                 125             


Ser Val Ile Ser Asn Tyr Asn Lys Ser Thr Asn Lys Gly Thr Asp Gln 
    130                 135                 140                 


Ile Leu Leu Thr Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Lys Ile 
145                 150                 155                 160 


Trp Thr Asn Gln Leu Cys Asn Val Glu Thr Ile Gln Trp Ser Asp Ile 
                165                 170                 175     


Val Asn Val Gly Asn Ile Ser Ile Asp Pro Thr Pro Ser Lys Asn Lys 
            180                 185                 190         


Asn Cys Gly Lys Cys Asp Ser Ser Cys Phe Asn Gly Ser Cys Trp Ser 
        195                 200                 205             


Pro Gly Pro Gln Asn Cys Gln Thr Leu Thr Lys Leu Asn Cys Ala Gln 
    210                 215                 220                 


Gln Cys Ser Arg Arg Cys Lys Gly Pro Ser Pro Ser Asp Cys Cys Asn 
225                 230                 235                 240 


Glu His Cys Ala Ala Gly Cys Thr Gly Pro Arg Ala Glu Asp Cys Leu 
                245                 250                 255     


Ala Cys Arg Asp Phe Gln Asp Asn Gly Val Cys Lys Asp Ser Cys Pro 
            260                 265                 270         


Gly Leu His Arg Tyr Asp Pro Asn Leu His Gln Leu Val Pro Asn Pro 
        275                 280                 285             


His Gly Lys Tyr Ser Phe Gly Ala Thr Cys Val Lys Ser Cys Pro Arg 
    290                 295                 300                 


Asn Tyr Ile Ile Ser Asp Tyr Gly Ala Cys Val Arg Thr Cys Asn Gly 
305                 310                 315                 320 


Asn Thr Tyr Glu Val Glu Val Gly Gly Ile Arg Lys Cys Ala Lys Cys 
                325                 330                 335     


Asp Gly Leu Cys Pro Lys Val Cys Asn Gly Leu Gly Thr Gly Asp Leu 
            340                 345                 350         


Val His Thr Leu Ser Ile Asn Ala Thr Asn Ile Gly Ser Phe Glu Asn 
        355                 360                 365             


Cys Thr Lys Ile Asn Gly Asn Ile Asp Ile Ile His Thr Ser Ile Tyr 
    370                 375                 380                 


Gly Asp Lys Phe Thr Lys Thr Pro Lys Met Asp Pro Glu Gln Leu Asn 
385                 390                 395                 400 


Val Phe Lys Thr Val Lys Glu Ile Thr Gly Tyr Leu Trp Ile Gln Thr 
                405                 410                 415     


Trp Pro Asp Thr Met Ser Ser Leu Ser Pro Phe Glu Asn Leu Glu Ile 
            420                 425                 430         


Val Arg Gly Arg Thr Lys Arg Gly Ser Arg Ser Leu Val Val Ser Gly 
        435                 440                 445             


Leu His Ile Thr His Leu Gly Leu Arg Ser Leu Arg Glu Ile Ser Asp 
    450                 455                 460                 


Gly Asp Val Phe Val Ser Lys Asn Ser Glu Leu Cys Tyr Thr Asp Ala 
465                 470                 475                 480 


Lys His Trp Gln Lys Leu Phe Lys Ser Pro His Gln Thr Val Asn Ile 
                485                 490                 495     


Glu Gly Asn Ala Asn Ala Ala Thr Cys Ala Leu Arg Asn Asp Thr Cys 
            500                 505                 510         


Asp Lys Lys Cys Thr Ala Asp Gly Cys Trp Gly Pro Gly Pro Ser Met 
        515                 520                 525             


Cys Ile Ser Cys Arg Asp Tyr Lys Arg Asp Gly Ser Cys Val Asp Ser 
    530                 535                 540                 


Cys Asn Ile Leu Glu Gly Glu Pro Arg Glu Thr Ala Val Asn Lys Thr 
545                 550                 555                 560 


Cys Ile Lys Cys His Pro Glu Cys Gln Pro Met Asn Gly Thr Ala Thr 
                565                 570                 575     


Cys Ser Ala Pro Gly Ser Ala Asn Cys Thr Lys Cys Ala Asn Phe Lys 
            580                 585                 590         


Asp Gly Leu Phe Cys Val Ser Arg Cys Pro Gln Gly Val Leu Gly Glu 
        595                 600                 605             


Asp Asp Ala Leu Val Trp Lys Tyr Ala Asp Glu Gln Lys Val Cys Gln 
    610                 615                 620                 


Leu Cys His Lys Asn Cys Thr Gln Gly Cys Ile Gly Pro Gly Leu Glu 
625                 630                 635                 640 


Gly Cys His Ser Lys Gly Pro Pro Gly Leu Ser Met Val Ala Ala Gly 
                645                 650                 655     


Val Val Gly Gly Leu Leu Ala Ala Leu Ile Ala Gly Leu Ser Val Phe 
            660                 665                 670         


Val Leu Leu Arg Arg Arg His Ile Lys Arg Lys Arg Thr Met Arg Arg 
        675                 680                 685             


Leu Leu Gln Glu Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu 
    690                 695                 700                 


Ala Pro Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Pro Glu Phe Lys 
705                 710                 715                 720 


Lys Ile Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly 
                725                 730                 735     


Leu Trp Val Pro Glu Gly Glu Asp Val Lys Ile Pro Val Ala Ile Lys 
            740                 745                 750         


Val Leu Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp 
        755                 760                 765             


Glu Ala Tyr Val Met Ala Ser Val Glu His Pro His Val Cys Arg Leu 
    770                 775                 780                 


Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met 
785                 790                 795                 800 


Pro Tyr Gly Cys Leu Leu Asp Tyr Val Lys Glu Asn Lys Asp Asn Ile 
                805                 810                 815     


Gly Ser Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met 
            820                 825                 830         


Asn Tyr Leu Glu Glu Arg His Leu Val His Arg Asp Leu Ala Ala Arg 
        835                 840                 845             


Asn Val Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly 
    850                 855                 860                 


Leu Ala Lys Leu Leu Lys Ala Asp Glu Lys Glu Tyr His Ala Asp Gly 
865                 870                 875                 880 


Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Asn Arg 
                885                 890                 895     


Thr Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp 
            900                 905                 910         


Glu Leu Met Thr Phe Gly Thr Lys Pro Tyr Asp Gly Ile Pro Ala Ser 
        915                 920                 925             


Glu Ile Ala Gly Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro 
    930                 935                 940                 


Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile 
945                 950                 955                 960 


Asp Ala Asp Ser Arg Pro Arg Phe Arg Glu Leu Ile Ala Glu Phe Thr 
                965                 970                 975     


Lys Met Ala Arg Asp Pro Pro Arg Tyr Leu Val Ile Gln Gly Asp Asp 
            980                 985                 990         


Arg Met His Leu Pro Ser Pro Ser  Asp Thr Lys Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Ile Ser  Gly Glu Asp Met Glu  Asp Ala Val Asp Ala  Asp Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Arg Gly Phe  Phe Ser Ser Pro Ser  Thr Ser Arg 
    1025                 1030                 1035             


Thr Pro  Leu Ile His Ser Thr  Ser Leu Asn Ser Ser  Ile Gly Thr 
    1040                 1045                 1050             


Cys His  Ser Arg Thr Gly Leu  Leu Asn Gly Phe Pro  Ser Arg Asp 
    1055                 1060                 1065             


Gly Ser  Met Ala Leu Arg Tyr  Ile Pro Asp Pro Thr  Asp Lys Phe 
    1070                 1075                 1080             


Leu Asp  Glu Ala Phe Gln Pro  Ala Pro Gly Tyr Ile  Asn Gln Thr 
    1085                 1090                 1095             


Pro Ile  Ser Asp Val Val Asn  Pro Ile Tyr Gln His  Pro Gly Pro 
    1100                 1105                 1110             


Pro Arg  Thr Leu Leu Pro Thr  Ile Ser Ser Asp His  Thr Glu Thr 
    1115                 1120                 1125             


Glu Tyr  Leu Asn Tyr Phe Lys  Asn Gly Ala Ala Gly  Pro Glu Tyr 
    1130                 1135                 1140             


Leu Asn  Glu Ile Leu Ser Pro  Ala Val Leu Pro Leu  Thr Ser Asn 
    1145                 1150                 1155             


Gly Thr  Val His Ser Ile Glu  Lys Tyr Leu Pro Gln  Gln Ser Ile 
    1160                 1165                 1170             


Asp Asn  Pro Asp Tyr Gln Gln  Asp Phe Thr Pro Thr  Phe Lys Thr 
    1175                 1180                 1185             


His Thr  Asn Gly His Ile Pro  Ala Ala Glu Asn Ala  Glu Tyr Leu 
    1190                 1195                 1200             


Gly Pro  Asp 
    1205     


<210>  36
<211>  416
<212>  PRT
<213>  Bos taurus

<400>  36

Met Gln Ala Leu Val Leu Leu Leu Trp Thr Gly Ala Leu Leu Gly Phe 
1               5                   10                  15      


Gly Arg Cys Gln Asn Ala Gly Gln Glu Ala Gly Ser Leu Thr Pro Glu 
            20                  25                  30          


Ser Thr Gly Ala Pro Val Glu Glu Glu Asp Pro Phe Phe Lys Val Pro 
        35                  40                  45              


Val Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly Tyr Asp Leu Tyr 
    50                  55                  60                  


Arg Val Arg Ser Gly Glu Ser Pro Thr Ala Asn Val Leu Leu Ser Pro 
65                  70                  75                  80  


Leu Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala Glu Gln 
                85                  90                  95      


Arg Thr Glu Ser Asn Ile His Arg Ala Leu Tyr Tyr Asp Leu Ile Ser 
            100                 105                 110         


Asn Pro Asp Ile His Gly Thr Tyr Lys Asp Leu Leu Ala Ser Val Thr 
        115                 120                 125             


Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Ile Phe Glu Arg 
    130                 135                 140                 


Lys Leu Arg Ile Lys Ala Ser Phe Ile Pro Pro Leu Glu Lys Ser Tyr 
145                 150                 155                 160 


Gly Thr Arg Pro Arg Ile Leu Thr Gly Asn Ser Arg Val Asp Leu Gln 
                165                 170                 175     


Glu Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly Lys Val Ala Arg 
            180                 185                 190         


Ser Thr Arg Glu Met Pro Ser Glu Ile Ser Ile Phe Leu Leu Gly Val 
        195                 200                 205             


Ala Tyr Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg Lys Thr 
    210                 215                 220                 


Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Lys Val Pro 
225                 230                 235                 240 


Met Met Ser Asp Pro Gln Ala Val Leu Arg Tyr Gly Leu Asp Ser Asp 
                245                 250                 255     


Leu Asn Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly Ser Thr Ser Ile 
            260                 265                 270         


Ile Phe Phe Leu Pro Gln Lys Val Thr Gln Asn Leu Thr Leu Ile Glu 
        275                 280                 285             


Glu Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp Arg Glu Leu Lys 
    290                 295                 300                 


Thr Val Gln Ala Val Leu Thr Ile Pro Lys Leu Lys Leu Ser Tyr Glu 
305                 310                 315                 320 


Gly Glu Leu Thr Lys Ser Val Gln Glu Leu Lys Leu Gln Ser Leu Phe 
                325                 330                 335     


Asp Ala Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys Leu Thr 
            340                 345                 350         


Gln Val Glu His Arg Val Gly Phe Glu Trp Asn Glu Asp Gly Ala Gly 
        355                 360                 365             


Thr Asn Ser Ser Pro Gly Val Gln Pro Ala Arg Leu Thr Phe Pro Leu 
    370                 375                 380                 


Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu Arg Asp Thr Asp 
385                 390                 395                 400 


Thr Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp Pro Arg Gly Thr 
                405                 410                 415     


<210>  37
<211>  217
<212>  PRT
<213>  Bos taurus

<400>  37

Met Met Ala Ala Gly Pro Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu 
1               5                   10                  15      


Leu Cys Leu Pro Trp Thr Gln Val Val Gly Ala Phe Pro Ala Met Ser 
            20                  25                  30          


Leu Ser Gly Leu Phe Ala Asn Ala Val Leu Arg Ala Gln His Leu His 
        35                  40                  45              


Gln Leu Ala Ala Asp Thr Phe Lys Glu Phe Glu Arg Thr Tyr Ile Pro 
    50                  55                  60                  


Glu Gly Gln Arg Tyr Ser Ile Gln Asn Thr Gln Val Ala Phe Cys Phe 
65                  70                  75                  80  


Ser Glu Thr Ile Pro Ala Pro Thr Gly Lys Asn Glu Ala Gln Gln Lys 
                85                  90                  95      


Ser Asp Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Gly Pro Leu Gln Phe Leu Ser Arg Val Phe Thr Asn Ser Leu Val 
        115                 120                 125             


Phe Gly Thr Ser Asp Arg Val Tyr Glu Lys Leu Lys Asp Leu Glu Glu 
    130                 135                 140                 


Gly Ile Leu Ala Leu Met Arg Glu Leu Glu Asp Gly Thr Pro Arg Ala 
145                 150                 155                 160 


Gly Gln Ile Leu Lys Gln Thr Tyr Asp Lys Phe Asp Thr Asn Met Arg 
                165                 170                 175     


Ser Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Ser Cys Phe Arg 
            180                 185                 190         


Lys Asp Leu His Lys Thr Glu Thr Tyr Leu Arg Val Met Lys Cys Arg 
        195                 200                 205             


Arg Phe Gly Glu Ala Ser Cys Ala Phe 
    210                 215         


<210>  38
<211>  204
<212>  PRT
<213>  Oreochromis niloticus

<400>  38

Met Asn Ser Val Val Leu Leu Leu Ser Val Val Cys Leu Gly Val Ser 
1               5                   10                  15      


Ser Gln Gln Ile Thr Asp Ser Gln Arg Leu Phe Ser Ile Ala Val Asn 
            20                  25                  30          


Arg Val Thr His Leu His Leu Leu Ala Gln Arg Leu Phe Ser Asp Phe 
        35                  40                  45              


Glu Ser Ser Leu Gln Thr Glu Glu Gln Arg Gln Leu Asn Lys Ile Phe 
    50                  55                  60                  


Leu Gln Asp Phe Cys Asn Ser Asp Tyr Ile Ile Ser Pro Ile Asp Lys 
65                  70                  75                  80  


His Glu Thr Gln Arg Ser Ser Val Leu Lys Leu Leu Ser Ile Ser Tyr 
                85                  90                  95      


Gly Leu Val Glu Ser Trp Glu Phe Pro Ser Arg Ser Leu Ser Gly Gly 
            100                 105                 110         


Ser Ser Leu Arg Asn Gln Ile Ser Pro Arg Leu Ser Glu Leu Lys Thr 
        115                 120                 125             


Gly Ile Leu Leu Leu Ile Arg Ala Asn Gln Asp Glu Ala Glu Asn Tyr 
    130                 135                 140                 


Pro Asp Thr Asp Thr Leu Gln His Ala Pro Tyr Gly Asn Tyr Tyr Gln 
145                 150                 155                 160 


Ser Leu Gly Gly Asn Glu Ser Leu Arg Gln Thr Tyr Glu Leu Leu Ala 
                165                 170                 175     


Cys Phe Lys Lys Asp Met His Lys Val Glu Thr Tyr Leu Thr Val Ala 
            180                 185                 190         


Lys Cys Arg Leu Ser Pro Glu Ala Asn Cys Thr Leu 
        195                 200                 


<210>  39
<211>  634
<212>  PRT
<213>  Bos taurus

<400>  39

Met Asp Leu Trp Gln Leu Leu Leu Thr Leu Ala Val Ala Gly Ser Ser 
1               5                   10                  15      


Asp Ala Phe Ser Gly Ser Glu Ala Thr Pro Ala Phe Leu Val Arg Ala 
            20                  25                  30          


Ser Gln Ser Leu Gln Ile Leu Tyr Pro Val Leu Glu Thr Asn Ser Ser 
        35                  40                  45              


Gly Asn Pro Lys Phe Thr Lys Cys Arg Ser Pro Glu Leu Glu Thr Phe 
    50                  55                  60                  


Ser Cys His Trp Thr Asp Gly Ala Asn His Ser Leu Gln Ser Pro Gly 
65                  70                  75                  80  


Ser Val Gln Met Phe Tyr Ile Arg Arg Asp Ile Gln Glu Trp Lys Glu 
                85                  90                  95      


Cys Pro Asp Tyr Val Ser Ala Gly Glu Asn Ser Cys Tyr Phe Asn Ser 
            100                 105                 110         


Ser Tyr Thr Ser Val Trp Thr Pro Tyr Cys Ile Lys Leu Thr Ser Asn 
        115                 120                 125             


Gly Gly Ile Val Asp His Lys Cys Phe Ser Val Glu Asp Ile Val Gln 
    130                 135                 140                 


Pro Asp Pro Pro Val Gly Leu Asn Trp Thr Leu Leu Asn Ile Ser Leu 
145                 150                 155                 160 


Thr Glu Ile His Ala Asp Ile Leu Val Lys Trp Glu Pro Pro Pro Asn 
                165                 170                 175     


Thr Asp Val Lys Met Gly Trp Ile Ile Leu Glu Tyr Glu Leu His Tyr 
            180                 185                 190         


Lys Glu Leu Asn Glu Thr Gln Trp Lys Met Met Asp Pro Leu Met Val 
        195                 200                 205             


Thr Ser Val Pro Met Tyr Ser Leu Arg Leu Asp Lys Glu Tyr Glu Val 
    210                 215                 220                 


Arg Val Arg Thr Arg Gln Arg Asn Thr Glu Lys Tyr Gly Lys Phe Ser 
225                 230                 235                 240 


Glu Val Leu Leu Ile Thr Phe Pro Gln Met Asn Pro Ser Ala Cys Glu 
                245                 250                 255     


Glu Asp Phe Gln Phe Pro Trp Phe Leu Ile Ile Ile Phe Gly Ile Leu 
            260                 265                 270         


Gly Leu Ala Val Thr Leu Tyr Leu Leu Ile Phe Ser Lys Gln Gln Arg 
        275                 280                 285             


Ile Lys Met Leu Ile Leu Pro Pro Val Pro Val Pro Lys Ile Lys Gly 
    290                 295                 300                 


Ile Asp Pro Asp Leu Leu Lys Glu Gly Lys Leu Glu Glu Val Asn Thr 
305                 310                 315                 320 


Ile Leu Ala Ile His Asp Asn Tyr Lys His Glu Phe Tyr Asn Asp Asp 
                325                 330                 335     


Ser Trp Val Glu Phe Ile Glu Leu Asp Ile Asp Asp Pro Asp Glu Lys 
            340                 345                 350         


Thr Glu Gly Ser Asp Thr Asp Arg Leu Leu Ser Asn Asp His Glu Lys 
        355                 360                 365             


Ser Leu Asn Ile Phe Gly Ala Lys Asp Asp Asp Ser Gly Arg Thr Ser 
    370                 375                 380                 


Cys Tyr Glu Pro Asp Ile Leu Glu Ala Asp Phe His Val Ser Asp Met 
385                 390                 395                 400 


Cys Asp Gly Thr Ser Glu Val Ala Gln Pro Gln Arg Leu Lys Gly Glu 
                405                 410                 415     


Ala Asp Ile Ser Cys Leu Asp Gln Lys Asn Gln Asn Asn Ser Pro Ser 
            420                 425                 430         


Asn Asp Ala Ala Pro Ala Ser Gln Gln Pro Ser Val Ile Leu Val Glu 
        435                 440                 445             


Glu Asn Lys Pro Arg Pro Leu Leu Ile Gly Gly Thr Glu Ser Thr His 
    450                 455                 460                 


Gln Ala Val His Thr Gln Leu Ser Asn Pro Ser Ser Leu Ala Asn Ile 
465                 470                 475                 480 


Asp Phe Tyr Ala Gln Val Ser Asp Ile Thr Pro Ala Gly Asn Val Val 
                485                 490                 495     


Leu Ser Pro Gly Gln Lys Asn Lys Thr Gly Asn Pro Gln Cys Asp Thr 
            500                 505                 510         


His Pro Glu Val Val Thr Pro Cys Gln Ala Asn Phe Ile Val Asp Asn 
        515                 520                 525             


Ala Tyr Phe Cys Glu Val Asp Ala Lys Lys Tyr Ile Ala Leu Ala Pro 
    530                 535                 540                 


His Val Glu Ala Glu Ser His Val Glu Pro Ser Phe Asn Gln Glu Asp 
545                 550                 555                 560 


Ile Tyr Ile Thr Thr Glu Ser Leu Thr Thr Thr Ala Gly Arg Ser Gly 
                565                 570                 575     


Thr Ala Glu His Val Pro Ser Ser Glu Ile Pro Val Pro Asp Tyr Thr 
            580                 585                 590         


Ser Ile His Ile Val Gln Ser Pro Gln Gly Leu Val Leu Asn Ala Thr 
        595                 600                 605             


Ala Leu Pro Leu Pro Asp Lys Glu Phe Leu Ser Ser Cys Gly Tyr Val 
    610                 615                 620                 


Ser Thr Asp Gln Leu Asn Lys Ile Met Pro 
625                 630                 


<210>  40
<211>  635
<212>  PRT
<213>  Oreochromis niloticus

<400>  40

Met Ala Leu Ser Pro Ser Ser Asn Leu Leu Ile Leu Leu Ile Leu Ser 
1               5                   10                  15      


Ser Leu Asp Trp Leu Pro Ser Pro Gly Ser Thr Phe Leu Thr Asp Trp 
            20                  25                  30          


Asp His Thr Thr Ser Ser Ala Leu Ile Glu Pro His Phe Thr Glu Cys 
        35                  40                  45              


Ile Ser Arg Asp Gln Glu Thr Phe His Cys Trp Trp Ser Pro Gly Ser 
    50                  55                  60                  


Phe His Asn Leu Ser Ser Pro Gly Ala Leu Arg Val Phe Tyr Leu Lys 
65                  70                  75                  80  


Lys Glu Pro Pro Thr Ser Gln Trp Lys Glu Cys Pro Glu Tyr Ile His 
                85                  90                  95      


Ser Asn Arg Glu Cys Phe Phe Asp Glu Ala His Thr Ser Ile Trp Ile 
            100                 105                 110         


Thr Tyr Cys Met Gln Leu Arg Thr Gln Asn Asn Ile Thr Tyr Phe Asn 
        115                 120                 125             


Glu Asp Asp Cys Phe Thr Val Glu Asn Ile Val Arg Pro Asp Pro Pro 
    130                 135                 140                 


Val Asn Leu Asn Trp Thr Leu Leu Asn Thr Ser Pro Ser Gly Leu Asn 
145                 150                 155                 160 


Tyr Asp Val Met Ile Asn Trp Glu Pro Pro Pro Thr Ala Asp Val Arg 
                165                 170                 175     


Leu Gly Trp Met Arg Val Glu Tyr Glu Leu Gln Tyr Arg Glu Arg Asn 
            180                 185                 190         


Thr Thr Asn Trp Glu Ala Leu Asp Ile Gln Arg Gln Ser His Gln Thr 
        195                 200                 205             


Ile Tyr Gly Leu Arg Leu Gly Lys Glu Tyr Glu Val His Ile Arg Cys 
    210                 215                 220                 


Arg Met Gln Ala Phe Ile Lys Phe Gly Glu Phe Ser Glu Ser Val Phe 
225                 230                 235                 240 


Ile Gln Val Thr Glu Ile Pro Ser Thr Glu Ser Thr Val His Leu Thr 
                245                 250                 255     


Leu Val Leu Val Phe Gly Thr Val Gly Ile Leu Ile Leu Ile Met Leu 
            260                 265                 270         


Ile Val Ile Ser Gln Gln Asn Arg Leu Met Ile Phe Leu Leu Pro Pro 
        275                 280                 285             


Val Pro Ala Pro Lys Ile Lys Gly Ile Asp Ser Glu Leu Leu Lys Lys 
    290                 295                 300                 


Gly Lys Leu Asp Glu Leu Asn Phe Met Leu Ser Gly Arg Gly Met Asp 
305                 310                 315                 320 


Gly Leu Pro Ile Tyr Ala Pro Asp Phe Tyr Gln Asp Glu Pro Trp Val 
                325                 330                 335     


Glu Leu Met Glu Val Asp Glu Thr Glu Asp Val Asp Asn Gly Glu Lys 
            340                 345                 350         


Lys Asp Asn Arg Gly Ser Asp Thr Gln Lys Leu Leu Gly Gln Ser Gln 
        355                 360                 365             


Pro Val Ser Gln His Ile Asn Ile Asn Cys Ser Asn Ser Val Ser Gly 
    370                 375                 380                 


Pro Asp Ala Glu Ser Ser Gln Ala Thr Cys Tyr Asn Thr Asp Leu Pro 
385                 390                 395                 400 


Glu Glu Glu Thr Leu Met Leu Met Ala Thr Leu Leu Pro Gly Gln Pro 
                405                 410                 415     


Asp Glu Glu Glu Thr Ser Leu Asp Thr Val Glu Arg Ser Ser Ala Ser 
            420                 425                 430         


Glu Thr Gly Glu Arg Gln Leu Ile Gln Thr Gln Thr Arg Gly Pro Gln 
        435                 440                 445             


Thr Trp Val Asn Thr Asp Phe Tyr Ala Gln Val Thr Asn Val Met Pro 
    450                 455                 460                 


Thr Gly Gly Val Val Leu Ser Pro Gly Gln Gln Leu Arg Ile Gln Glu 
465                 470                 475                 480 


Ser Ile Ser Ala Ala Glu Lys Glu Thr Lys Lys Lys Arg Lys Glu Ser 
                485                 490                 495     


Glu Asp Ser Glu Glu Ser Glu Glu Arg Lys Gln Lys Glu Pro Gln Phe 
            500                 505                 510         


Gln Leu Leu Val Val Asp Pro Glu Gly Ser Ala Tyr Ser Thr Glu Ser 
        515                 520                 525             


Ser Ile Gln Gln Ile Ser Thr Pro Pro Pro Ser Ser Pro Met Pro Gly 
    530                 535                 540                 


Glu Gly Tyr His Ile Ile His Pro Gln Pro Val Glu Pro Arg Pro Ala 
545                 550                 555                 560 


Ala Thr Met Glu Leu Asn Gln Ser Pro Tyr Ile Ile Pro Asp Ser Pro 
                565                 570                 575     


Gln Phe Phe Ala Pro Val Ala Asp Tyr Thr Val Val Gln Glu Leu Asp 
            580                 585                 590         


Ser His His Ser Leu Leu Leu Asn Pro Pro Cys His Gln Thr Pro Pro 
        595                 600                 605             


Pro Cys Leu Pro Gln His Pro Leu Lys Ala Pro Met Pro Val Gly Tyr 
    610                 615                 620                 


Ile Thr Pro Asp Leu Leu Gly Asn Leu Ser Gln 
625                 630                 635 


<210>  41
<211>  208
<212>  PRT
<213>  Bos taurus

<400>  41

Met Asn Ser Arg Phe Thr Ser Ala Phe Thr Pro Phe Ala Val Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Met Thr Ser Ala Phe Pro Thr Pro Gly Pro Leu 
            20                  25                  30          


Gly Glu Asp Phe Lys Asn Asp Thr Thr Pro Gly Arg Leu Leu Leu Thr 
        35                  40                  45              


Thr Pro Glu Lys Thr Glu Ala Leu Ile Lys Arg Met Val Asp Lys Ile 
    50                  55                  60                  


Ser Ala Met Arg Lys Glu Ile Cys Glu Lys Asn Asp Glu Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Thr Leu Ala Glu Asn Lys Leu Asn Leu Pro Lys Met Glu 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Gln Ala Ile Cys Leu 
            100                 105                 110         


Ile Arg Thr Thr Ala Gly Leu Leu Glu Tyr Gln Ile Tyr Leu Asp Tyr 
        115                 120                 125             


Leu Gln Asn Glu Tyr Glu Gly Asn Gln Glu Asn Val Arg Asp Leu Arg 
    130                 135                 140                 


Lys Asn Ile Arg Thr Leu Ile Gln Ile Leu Lys Gln Lys Ile Ala Asp 
145                 150                 155                 160 


Leu Ile Thr Thr Pro Ala Thr Asn Thr Asp Leu Leu Glu Lys Met Gln 
                165                 170                 175     


Ser Ser Asn Glu Trp Val Lys Asn Ala Lys Ile Ile Leu Ile Leu Arg 
            180                 185                 190         


Asn Leu Glu Asn Phe Leu Gln Phe Ser Leu Arg Ala Ile Arg Met Lys 
        195                 200                 205             


<210>  42
<211>  220
<212>  PRT
<213>  Oreochromis niloticus

<400>  42

Met Pro Ser Ile Phe Asn Leu His Phe Ser Ser Ala Val Met Leu Ala 
1               5                   10                  15      


Ala Leu Leu Leu Cys Ala Ser Gly Ala Pro Ile Glu Asp Gly Ser Val 
            20                  25                  30          


Ala Gly Asp Phe Ser Gly Glu Glu Thr Glu Glu Ala Glu Met Ser Thr 
        35                  40                  45              


Val Lys Pro Phe Asn Ile Trp Arg Ser Leu Phe Asp Ser Ala Gln Glu 
    50                  55                  60                  


Tyr Glu Lys Ala Phe Glu His His Phe Gln Thr Leu Glu Asn Arg Asp 
65                  70                  75                  80  


Gln Ala Leu Asp Ser His Thr Pro Ala Ser Ile Pro Lys His Cys Asn 
                85                  90                  95      


Ile Thr Lys Phe Arg Lys Asp Ala Cys Leu Gln Thr Leu Ala Lys Gly 
            100                 105                 110         


Leu Leu Ile Tyr Ser Val Leu Leu Lys His Val Glu Lys Glu Tyr Arg 
        115                 120                 125             


Ser Ser Leu Asn Phe Ser Asp Ala Pro Ser Asn Ile Gly Thr Leu Ile 
    130                 135                 140                 


Asp Leu Ala Gly Met Val Lys Gly Lys Met Lys Asn Arg Asn Gln Val 
145                 150                 155                 160 


Thr Pro Leu Thr Ser Ser Glu Glu Glu Gln Leu Leu Lys Glu Val Asn 
                165                 170                 175     


Ser Pro Asp Pro Tyr His Arg Lys Leu His Ala Tyr Ser Ile Leu Arg 
            180                 185                 190         


Ala Leu Lys Ala Phe Leu Ser Glu Gly Lys Arg Ala Val Cys Arg Met 
        195                 200                 205             


Glu Lys Arg Val Asn Gln Ser Ala Asp Thr Ser Cys 
    210                 215                 220 


<210>  43
<211>  464
<212>  PRT
<213>  Bos taurus

<400>  43

Met Leu Ala Val Arg Cys Ala Leu Leu Thr Ala Leu Leu Ala Ala Ser 
1               5                   10                  15      


Gly Thr Ala Leu Val Leu Lys Gly Cys Pro Ala Leu Glu Val Ala Ser 
            20                  25                  30          


Asp Val Leu Thr Ser Val Pro Gly Ala Asn Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Gly Gly Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Asp 
    50                  55                  60                  


Gln Met Thr Gly Ser His His Gly Arg Pro Ala Gly Val Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Gln Ser Val Gln Leu Ser Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Glu Asp His Pro Ala Gly Ser Val Arg Leu Val Val Asp Val 
            100                 105                 110         


Pro Pro Glu Lys Pro Gln Ile Ser Cys Ile Gln Lys Ser Pro Leu Ser 
        115                 120                 125             


Arg Val Asn Cys Glu Trp Ser Pro Arg Ser Pro Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Lys Lys Phe Pro Lys Gln Val Phe Gln Glu 
145                 150                 155                 160 


Pro Cys Gln Tyr Ser Pro Glu Ser Gln Arg Phe Ser Cys Gln Leu Ala 
                165                 170                 175     


Val Pro Glu Gly Asp Ser Ser Phe Tyr Val Leu Ser Leu Cys Val Ala 
            180                 185                 190         


Asn Ser Ala Gly Asn Lys Ser Ser Asn Pro Leu Gly Phe Asp Gly Tyr 
        195                 200                 205             


Lys Leu Leu Gln Pro Asp Pro Pro Val Asn Ile Thr Val Ser Ala Val 
    210                 215                 220                 


Asp Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp Pro Pro Ser 
225                 230                 235                 240 


Trp Asn Ser Tyr Tyr Tyr Arg Leu Gln Phe Glu Leu Arg Tyr Arg Thr 
                245                 250                 255     


Glu Arg Ser Glu Thr Phe Thr Thr Leu Met Leu Lys Asp Pro Gln Tyr 
            260                 265                 270         


His Cys Ile Ile Asn Asp Ala Trp Ser Gly Met Arg His Val Val Gln 
        275                 280                 285             


Leu Arg Ala Gln Glu Glu Phe Gly Asn Gly Leu Trp Ser Glu Trp Ser 
    290                 295                 300                 


Pro Glu Val Thr Gly Thr Pro Trp Thr Glu Ser Arg Ser Ser Thr Thr 
305                 310                 315                 320 


Thr Lys Leu Pro Thr Ser Thr Gln Ala Pro Thr Thr Thr Glu Asp Asn 
                325                 330                 335     


Glu Asn Ile Phe Ser Lys Asp Ser Ala Lys Thr Thr Ser Leu Pro Val 
            340                 345                 350         


Gln Asp Ser Thr Ser Val Pro Leu Pro Ala Phe Leu Val Ala Gly Gly 
        355                 360                 365             


Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Gly Ile Ile Leu Arg Phe 
    370                 375                 380                 


Lys Lys Thr Gly Lys Leu Gln Ala Leu Lys Glu Gly Lys Thr Ser Ala 
385                 390                 395                 400 


His Pro Ser Tyr Ser Leu Gly Gln Leu Val Pro Glu Arg Pro Lys Pro 
                405                 410                 415     


Thr Pro Ala Leu Val Pro Leu Ile Ser Pro Pro Val Ser Pro Ser Ser 
            420                 425                 430         


Leu Glu Ser Asp Asn Thr Ser Arg Asn Ser Arg Pro Asp Ala Lys Gly 
        435                 440                 445             


Pro Gly Ser Pro Tyr Asp Val Ser Asn Arg Asp Tyr Phe Phe Pro Arg 
    450                 455                 460                 


<210>  44
<211>  892
<212>  PRT
<213>  Oreochromis niloticus

<400>  44

Met Val Ser Ala Ala Val Leu His Leu Cys Val Leu Ala Trp Val Ala 
1               5                   10                  15      


Ser Val Leu Ala Ala Asp Asp Tyr His Leu Val Ile Ala Pro Gln Ser 
            20                  25                  30          


Pro Val Val Gln Ile Gly Ser Asn Phe Thr Ala Thr Cys Met Ile Ile 
        35                  40                  45              


Asn Thr Thr Glu Val Thr Ala Asp Asp Leu Tyr Trp Lys Cys Ser Glu 
    50                  55                  60                  


Ile Ile Pro Lys Glu His Tyr Ile Lys Ile Asn Thr Ser Ala Leu Asn 
65                  70                  75                  80  


Val Thr Val Thr Ile Arg Ser Glu Lys Ser Glu Trp Leu Leu Cys Lys 
                85                  90                  95      


Cys Lys Thr Val Ser Gln Tyr Val Ala Leu Asn Glu Gly Lys Phe Ile 
            100                 105                 110         


His Gly Ile Leu Leu Arg Lys Gly Tyr Arg Pro Glu Lys Pro Lys Asn 
        115                 120                 125             


Leu Ser Cys Ile Ala Val His Glu Ser Glu Lys Ile Ser Ser Asn Ile 
    130                 135                 140                 


Arg Cys Gln Trp Glu Ala Val Gly Asn Gln Thr Glu Ala Val Pro Thr 
145                 150                 155                 160 


Asn Tyr Thr Leu Phe Val Arg Gln Thr Gly Ser Asp Lys Val Tyr Thr 
                165                 170                 175     


Ala Ser Ile Leu Gly Pro Val Asn Ser Thr Thr Val Asp Met Asn Phe 
            180                 185                 190         


Phe Pro His His Met Glu Leu Glu Ile Trp Val Val Ala Gln Asn Glu 
        195                 200                 205             


Leu Gly Lys Glu Glu Ser Glu His Leu Ile Lys Leu Ala Asn Cys Phe 
    210                 215                 220                 


Val Lys Thr Lys Pro Pro Ser Val Thr Val Ile Ser Glu Ala Val Phe 
225                 230                 235                 240 


Pro Thr Ser Leu Val Met Asn Trp Thr Ser Ser Ile Asp Lys Arg Tyr 
                245                 250                 255     


Leu Glu Thr Ile Tyr Glu Ile Arg Tyr Cys Pro Leu Gly Ser Gln Met 
            260                 265                 270         


Trp Ile Tyr Val Pro Leu Glu Asp Thr Ser Arg Tyr Ile Gln Ser Phe 
        275                 280                 285             


Arg Leu Gln Asn Leu Thr Pro Asp Thr Val Tyr Val Thr Gln Val Arg 
    290                 295                 300                 


Cys Lys Tyr Asn Asn Lys Asn Cys Gly Tyr Trp Ser Asp Trp Ser Arg 
305                 310                 315                 320 


Asn Val Thr Glu Arg Thr Pro Glu Asp Leu Pro Thr Ser Lys Pro Asp 
                325                 330                 335     


Val Trp Ile Ile Thr Ser Ala Glu Gly Ile Asn Lys Arg Gln Ile Glu 
            340                 345                 350         


Phe Ile Cys Lys Asp Pro Glu Val Ser Asn Gly Arg Ile Arg Arg Phe 
        355                 360                 365             


Asn Ile Thr Ile Glu Lys Gln Lys Tyr Arg Ile Arg Asn Gly Thr Trp 
    370                 375                 380                 


Glu Ile Ile Pro Val Asn Arg Ser Leu Thr Asp Gly Ser Ser Ser Lys 
385                 390                 395                 400 


Lys Gln Phe Thr Pro Leu Lys Thr Ile Arg Leu Asp Asp Glu Glu Ser 
                405                 410                 415     


Val Thr Val Tyr Val Thr Ala Ile Asn Ser Val Gly Ala Ser Pro Gln 
            420                 425                 430         


Ala Lys Leu Ile Ile Tyr Arg Lys Ala Arg Glu Pro Pro Ala Val Glu 
        435                 440                 445             


Lys Met Glu Val Gln Phe Leu Asp Gly Gln Leu Leu Ile Ser Trp Lys 
    450                 455                 460                 


Ser Pro Asn Arg Thr Val Ser Glu Tyr Val Val Glu Trp Val Gly Asp 
465                 470                 475                 480 


Gly Glu Arg Asn Trp Gln Arg Glu Asn Gly Lys Ala Asn Cys Ser Thr 
                485                 490                 495     


Ile Lys Gly Asp Leu Lys Arg Phe Val His Tyr Arg Ile Ser Val Tyr 
            500                 505                 510         


Pro Ile Tyr Gly Lys Val Val Gly Lys Pro Val His Glu Gln Ala Tyr 
        515                 520                 525             


Ala Glu Gln Gly Val Pro Ser Gln Ala Pro Thr Val Asn Leu Ser Gly 
    530                 535                 540                 


Asp Pro Gly Cys Tyr Thr Ala Lys Leu Glu Trp Asp Glu Ile Pro Leu 
545                 550                 555                 560 


Ile Lys Arg Arg Gly Phe Ile Thr Asn Tyr Thr Ile Tyr Tyr Arg Ser 
                565                 570                 575     


Gly Thr Glu Thr His Gly Ile Ile Val Pro Pro Asn Thr Thr Ser Tyr 
            580                 585                 590         


Thr Leu Thr Ser Leu Ser Arg Asn Thr Lys Tyr Asp Ile Trp Ile Lys 
        595                 600                 605             


Ala Ser Thr Ile Arg Gly Ser Val Asn Gly Ser Asn His Ser Phe Thr 
    610                 615                 620                 


Thr Leu Lys Tyr Ala Pro Gly Glu Ile Glu Gly Ile Val Val Gly Val 
625                 630                 635                 640 


Ser Leu Gly Phe Leu Phe Val Val Leu Met Thr Met Leu Leu Cys Phe 
                645                 650                 655     


Cys Lys Lys Asp Val Ile Lys Asp Asn Phe Trp Pro Gln Ile Pro Asn 
            660                 665                 670         


Pro Gly Asp Ser Thr Ile Gly Asn Trp Ser Pro Asp Tyr Pro Leu Lys 
        675                 680                 685             


Ala Glu Ala Pro Arg Glu Asn Cys Leu Ser Gly Ile Ser Val Leu Asn 
    690                 695                 700                 


Val Asp Val Cys Asp Ala Lys Cys Val Phe Glu Glu Asp Lys Ala Ser 
705                 710                 715                 720 


Leu Pro Leu Lys Lys Asp Lys Tyr Leu Ser Glu Glu His Ser Ser Gly 
                725                 730                 735     


Ile Gly Gly Ser Ser Cys Met Ser Ser Pro Arg Gln Ser Val Ser Asp 
            740                 745                 750         


Ser Asp Glu Gly Gly Asp Met Ala Asp Thr Thr Ala Ser Thr Ile Gln 
        755                 760                 765             


Tyr Ser Ser Val Val Ala Ser Ser Gly Tyr Lys Gly Gln Asn Pro Ser 
    770                 775                 780                 


Ser Leu Pro Gln Gln Ser Ile Phe Ser Arg Ser Glu Ser Thr Gln Pro 
785                 790                 795                 800 


Leu Leu Asp Cys Glu Glu Asn His Asp Thr Met Val Gln Glu Gly Ser 
                805                 810                 815     


Arg Gln Cys Phe Leu Arg Gln Pro Cys Phe Asn His Asn Ala Gly Asn 
            820                 825                 830         


Glu Asn Ala Thr Asp Ser Asn Asp Phe Asn Pro Leu Glu Met Glu Gln 
        835                 840                 845             


Gln Glu Val Leu Asp Phe Cys Pro Leu Glu Glu Asp Thr Glu His Thr 
    850                 855                 860                 


Ala Pro Thr Asp Cys Gln Ser Asp Asp Trp Ile Pro Ala Thr Val Ser 
865                 870                 875                 880 


Ser Tyr Met Pro Gln Leu Gly Gly Tyr Arg Pro Gln 
                885                 890         


<210>  45
<211>  300
<212>  PRT
<213>  Bos taurus

<400>  45

Met Val Pro Ala Pro Arg Ala Gln Pro Ala Arg Gly Pro Ala Gly Trp 
1               5                   10                  15      


Arg Ala Arg Gln Gly Ala Pro Leu Pro Ser Ser Ser Ser Ser Ser Leu 
            20                  25                  30          


Leu Asn Ser Arg Arg Cys Ser Ser Arg Ser Ala Leu Ser Gly Ile His 
        35                  40                  45              


Pro Pro Ser Phe Leu Ser Phe Ser Phe Phe Pro Leu Ser Phe Pro Thr 
    50                  55                  60                  


Ala Ser Pro Ala Ala Pro Trp Glu Gly Arg Arg Pro Pro Glu Gln Leu 
65                  70                  75                  80  


Ala Asn Ser Gly Pro Gly Arg Glu Gln Val Pro Pro Pro Ser Ala Arg 
                85                  90                  95      


Ala Gly Lys Leu Trp Ser Val Leu Gly Val Val Pro Leu Leu Leu Val 
            100                 105                 110         


Leu His Trp Lys His Gly Ala Gly Ser Pro Leu Pro Ile Thr Pro Val 
        115                 120                 125             


Asn Ala Thr Cys Ala Thr Arg His Pro Cys Pro Ser Asn Leu Met Asn 
    130                 135                 140                 


Gln Ile Arg Asn Gln Leu Gly Gln Leu Asn Ser Ser Ala Asn Ser Leu 
145                 150                 155                 160 


Phe Ile Leu Tyr Tyr Thr Ala Gln Gly Glu Pro Phe Pro Asn Asn Leu 
                165                 170                 175     


Asp Lys Leu Cys Ser Pro Asn Val Thr Asp Phe Pro Pro Phe His Ala 
            180                 185                 190         


Asn Gly Thr Glu Lys Ala Arg Leu Val Glu Leu Tyr Arg Ile Ile Ala 
        195                 200                 205             


Tyr Leu Gly Ala Ser Leu Gly Asn Ile Thr Arg Asp Gln Lys Val Leu 
    210                 215                 220                 


Asn Pro Tyr Ala His Gly Leu His Ser Lys Leu Ser Thr Thr Ala Asp 
225                 230                 235                 240 


Val Leu Arg Gly Leu Leu Ser Asn Val Leu Cys Arg Leu Cys Ser Lys 
                245                 250                 255     


Tyr His Val Ser His Val Asp Val Thr Tyr Gly Pro Asp Thr Ser Gly 
            260                 265                 270         


Lys Asp Val Phe Gln Lys Lys Lys Leu Gly Cys Gln Leu Leu Gly Lys 
        275                 280                 285             


Tyr Lys Gln Val Ile Ala Val Leu Ala Gln Ala Phe 
    290                 295                 300 


<210>  46
<211>  991
<212>  PRT
<213>  Oreochromis niloticus

<400>  46

Met Ala His Leu Ser Leu Thr Pro Thr Leu Lys Leu Ile Ser Ser Gly 
1               5                   10                  15      


Phe Val Trp Leu Leu Trp Ile Val Leu Trp Phe Ser Thr Ser His Thr 
            20                  25                  30          


His Ala Asp Thr Gly Leu Thr Val Pro Gln Gln Val Thr Leu Ser Pro 
        35                  40                  45              


Asn Trp Gly Thr Gln Glu Leu Ser Ile Ser Trp Leu Gly Gly Gly Ala 
    50                  55                  60                  


Thr Thr Phe Asp Leu Ile Ile Leu Arg Thr Glu Phe Asn Glu Thr Val 
65                  70                  75                  80  


Phe Tyr Glu Thr Val Ser Pro Thr Val Asn Lys Val Ser Gly Leu His 
                85                  90                  95      


Gln Trp Thr Trp Thr Ser Val Asn Pro Leu Glu Cys Thr Ser Leu Ser 
            100                 105                 110         


Val Lys Ile Arg Ser Arg Ala Gly Gln Tyr Thr Ser Glu Trp Ser Gln 
        115                 120                 125             


Thr Glu Thr Leu Gln Gly His Asp His Pro Asn Ser Glu Gln Arg Val 
    130                 135                 140                 


Lys Ala Phe Pro Gln Asp Lys Val Leu Pro Val Gly Ala Asn Ile Thr 
145                 150                 155                 160 


Phe Cys Cys Ile Met Asp Glu Arg Met Phe Phe Asp Lys Ile Val Tyr 
                165                 170                 175     


Asp Gly Asn Ala Thr Ile Val Thr Arg Leu Ser Arg Arg Thr Tyr Ser 
            180                 185                 190         


Thr Thr Val Ser Asn Leu Val Ala Ser Arg Pro Ser Gly Ser Asn Met 
        195                 200                 205             


Leu Cys Leu Pro Glu Asp Lys Gly Lys Leu Tyr Gly Ala Val Val Phe 
    210                 215                 220                 


Val Gly Tyr Pro Pro Leu Pro Thr Asp Phe Lys Cys Glu Thr Tyr Asp 
225                 230                 235                 240 


Leu Arg Ser Ala Val Cys Gln Trp Gly Lys Gly Arg Asp Thr His Leu 
                245                 250                 255     


Tyr Gly Ile Gln Arg Gly Thr Arg Tyr Phe Val Asn Asn Arg Asp Cys 
            260                 265                 270         


Thr Glu Val Asn Gln Asp Val Gly Gln Lys Glu Leu Asn Cys Thr Leu 
        275                 280                 285             


Asp Thr Trp Glu Gly Asn Trp Thr Leu Val Ala Lys Asn Leu Leu Gly 
    290                 295                 300                 


Gln Tyr Ser Leu Thr Asp Thr Ala Glu Leu Ser His Arg Val Cys Pro 
305                 310                 315                 320 


Val Ala Pro Val Gln Leu Arg Val Val Ala Asp Ala Trp Asn Ala Ser 
                325                 330                 335     


Leu Ser Trp His Trp Lys Tyr Asp Ser Tyr Ser Ser Leu Ala Leu Asp 
            340                 345                 350         


Cys Gln Val Glu Val Thr Ala Thr Glu Asp Glu Lys Leu Ile Lys Arg 
        355                 360                 365             


Val Phe Ser Gly Val Gly Leu Arg Ser Val Phe Leu Ser Asp Leu Tyr 
    370                 375                 380                 


Pro Asp Glu Arg Tyr Ser Val Lys Val Arg Cys Gly Val Gln Gln Asn 
385                 390                 395                 400 


Phe Trp Lys Trp Gly Lys Trp Ser Glu Leu Phe Ser Phe Lys Thr Lys 
                405                 410                 415     


Thr Tyr Val Pro Asp Thr Pro Asp Ala Trp Ile Trp Leu Asn Thr Asp 
            420                 425                 430         


Asn Thr Gly Thr Val Val Trp Lys Pro Leu Thr Arg Arg Gln Ser His 
        435                 440                 445             


Gly Lys Leu Thr Gln Tyr Glu Val Phe Leu Trp Ser Pro Glu Glu Asn 
    450                 455                 460                 


Arg Ala Leu Ala Pro Thr Val Thr Leu Pro Pro Asn Thr Trp Ser Met 
465                 470                 475                 480 


Pro Val Asn Leu Thr Glu Ile Ala Phe Phe Ser Asn Asn Ser Ser Ile 
                485                 490                 495     


Val Ala Asn Val Thr Ala Arg Asn Asp Ala Gly Ser Ser Ser Pro Ala 
            500                 505                 510         


Arg Val His Leu Thr Ser Val Glu Pro Leu Ala Ala Ser Arg Ile Val 
        515                 520                 525             


Tyr Thr Asp Gln Gly Phe Pro Leu Phe Trp Glu Asn Asn Ala Asn Ala 
    530                 535                 540                 


Thr Cys Gly Tyr Val Val Glu Trp Leu Asp Ala Phe Cys Ser Gln Gly 
545                 550                 555                 560 


Cys Pro Val Glu Trp Ile Lys Leu Pro Ala Gly Thr Thr Asn Val Ser 
                565                 570                 575     


Leu Glu Ser Asp Thr Phe Gln Pro Gly Val Arg Tyr Asn Leu Ser Leu 
            580                 585                 590         


Tyr Ser Cys Ser Ser Asp Ser Arg Glu Leu Leu Lys Arg Trp Gln Gly 
        595                 600                 605             


Tyr Ala Gln Glu Leu Val Pro Ser Val Ala Leu Thr Leu Ser Ala Ser 
    610                 615                 620                 


Gln Gln Asn Ala Asp Ile Leu Leu Thr Trp Asn Glu Ile Pro Leu Val 
625                 630                 635                 640 


Asn Arg Arg Gly Phe Leu Leu Gly Tyr Asn Ile Tyr Asn Ser Thr Gly 
                645                 650                 655     


Tyr Gln Phe Asp Leu Leu Ala Asn Leu Pro Asp Pro Glu Thr Met Ser 
            660                 665                 670         


Tyr Thr Ala Lys Asp Phe Thr Lys Gly Thr Tyr Lys Phe Thr Val Lys 
        675                 680                 685             


Ala Tyr Thr Ala Ala Gly Glu Asn Thr Gly Thr Thr Ala Thr Val Thr 
    690                 695                 700                 


Ile Glu Pro Tyr Ala Asp Trp Leu Ile Leu Glu Ile Leu Thr Ser Leu 
705                 710                 715                 720 


Gly Leu Val Thr Leu Leu Leu Ala Ile Val Thr Phe Thr Cys Tyr Lys 
                725                 730                 735     


Lys Arg Lys Trp Val Lys Lys Ala Phe Tyr Pro Asp Ile Pro Glu Pro 
            740                 745                 750         


Lys Leu Pro Ser Asp Trp Pro Arg Thr Gln Gly Pro Leu Asp Val Lys 
        755                 760                 765             


Pro Ser Pro His Ser Met Val Cys Val Val Glu Thr Pro Glu Tyr Asp 
    770                 775                 780                 


Cys Ile Lys Glu Met Leu Val Ala Ile Pro Glu Glu Asp Glu Asp Asp 
785                 790                 795                 800 


Glu Gly Gln Gly Ile Gly Asp Glu Ser Val Asp Thr Asp Glu Pro Met 
                805                 810                 815     


Ser Leu Arg Tyr Tyr Asn Gln Met Val Asp Glu Arg Pro Ile Arg Pro 
            820                 825                 830         


Arg Phe Pro Asp Ser Ser Ala Ser Ser Leu Ser Ser Met Gly Ser Ala 
        835                 840                 845             


His Thr Asp Val Thr Tyr Thr Gly Ile Gln Thr Ser Gly Ser Ser Leu 
    850                 855                 860                 


Val Leu Gln Leu Asp Pro Gln Gly Ser Thr Glu Cys Tyr Gln Pro Gln 
865                 870                 875                 880 


Leu Asp Gln Ser Val Ser Tyr Gly Gly Gly Gly Tyr Arg Pro Gln Met 
                885                 890                 895     


Gln Pro Arg Ala Pro Ser Asp Asp Met Gly Leu Pro Ser Pro Glu Ser 
            900                 905                 910         


Phe Leu Glu Pro Gln Ala Ala Cys Ser Gly Gly Tyr Lys Pro Gln Gly 
        915                 920                 925             


Ser Trp His Leu Asp Ser Pro Val Asp Ala Ala Glu Met Gly Ser Leu 
    930                 935                 940                 


Ala Pro Ser Leu Gly Ser Pro Thr Ser Val Ala Ser Thr Gln Phe Leu 
945                 950                 955                 960 


Leu Pro Asp Gly Glu Glu Asn Arg Gly Glu Lys Arg Gln His Ser Ser 
                965                 970                 975     


Ser Ala Ala Ser Trp Leu Thr Asn Leu Leu Ser Ser Thr Lys Pro 
            980                 985                 990     


<210>  47
<211>  234
<212>  PRT
<213>  Bos taurus

<400>  47

Met Ser Thr Lys Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Val 
1               5                   10                  15      


Leu Ser Glu Lys Ala Gly Gly Pro Gln Gly Ser Arg Ser Cys Leu Cys 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Leu Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Gln Ser 
    50                  55                  60                  


Pro Gly Gly Pro Ser Ile Asn Ser Pro Leu Val Gln Thr Leu Arg Ser 
65                  70                  75                  80  


Ser Ser Gln Ala Ser Ser Asn Lys Pro Val Ala His Val Val Ala Asp 
                85                  90                  95      


Ile Asn Ser Pro Gly Gln Leu Arg Trp Trp Asp Ser Tyr Ala Asn Ala 
            100                 105                 110         


Leu Met Ala Asn Gly Val Lys Leu Glu Asp Asn Gln Leu Val Val Pro 
        115                 120                 125             


Ala Asp Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Arg Gly Gln 
    130                 135                 140                 


Gly Cys Pro Ser Thr Pro Leu Phe Leu Thr His Thr Ile Ser Arg Ile 
145                 150                 155                 160 


Ala Val Ser Tyr Gln Thr Lys Val Asn Ile Leu Ser Ala Ile Lys Ser 
                165                 170                 175     


Pro Cys His Arg Glu Thr Pro Glu Trp Ala Glu Ala Lys Pro Trp Tyr 
            180                 185                 190         


Glu Pro Ile Tyr Gln Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
        195                 200                 205             


Leu Ser Ala Glu Ile Asn Leu Pro Asp Tyr Leu Asp Tyr Ala Glu Ser 
    210                 215                 220                 


Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230                 


<210>  48
<211>  247
<212>  PRT
<213>  Oreochromis niloticus

<400>  48

Met Val Ala Tyr Thr Thr Thr Pro Val Asp Val Glu Ala Gly Pro Glu 
1               5                   10                  15      


Ala Lys Thr Val Val Leu Val Glu Lys Lys Ser Pro Ala Glu Trp Ile 
            20                  25                  30          


Trp Lys Val Cys Ala Val Leu Val Val Val Ala Leu Cys Leu Ala Gly 
        35                  40                  45              


Val Leu Leu Phe Ala Trp Tyr Trp Asn Thr Arg Pro Glu Arg Met Thr 
    50                  55                  60                  


Gln Leu Gly Gln Pro Glu Ala Leu Lys Ala Lys Asn Thr Gly Asp Lys 
65                  70                  75                  80  


Thr Glu Pro His Ser Thr Leu Lys Arg Ile Ser Ser Lys Ala Lys Ala 
                85                  90                  95      


Ala Ile His Leu Glu Gly Ser Asp Ser Lys Gly His Leu Glu Trp Arg 
            100                 105                 110         


Asn Gly Gln Gly Gln Ala Phe Ala Gln Gly Gly Phe Lys Leu Glu Ala 
        115                 120                 125             


Asn Lys Ile Ile Ile Pro His Thr Gly Leu Tyr Phe Val Tyr Ser Gln 
    130                 135                 140                 


Ala Ser Phe Arg Val Ile Cys Gly Asn Thr Asp Glu Asn Glu Asp Glu 
145                 150                 155                 160 


Glu Lys Ser Leu Thr Ile Leu Ser His Arg Ile Trp Arg Tyr Ser Glu 
                165                 170                 175     


Ser Met Gly Ser Ser Ser Thr Leu Met Ser Ala Leu Arg Ser Ala Cys 
            180                 185                 190         


Gln Asp Thr Ile Gln Asp Ser Phe Ser Asp His Gly Trp Tyr Asn Ala 
        195                 200                 205             


Ile Tyr Leu Gly Ala Val Phe Gln Leu Asn Glu Gly Asp Thr Leu Trp 
    210                 215                 220                 


Thr Glu Thr Asn Gln Leu Ser Glu Leu Glu Thr Asp Glu Gly Arg Thr 
225                 230                 235                 240 


Phe Phe Gly Val Phe Ala Leu 
                245         


<210>  49
<211>  190
<212>  PRT
<213>  Bos taurus

<400>  49

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gln Lys Pro His Glu Val Val Lys Phe Met Asp Val Tyr Gln Arg 
        35                  40                  45              


Ser Phe Cys Arg Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu Tyr 
    50                  55                  60                  


Pro Asp Glu Ile Glu Phe Ile Phe Lys Pro Ser Cys Val Pro Leu Met 
65                  70                  75                  80  


Arg Cys Gly Gly Cys Cys Asn Asp Glu Ser Leu Glu Cys Val Pro Thr 
                85                  90                  95      


Glu Glu Phe Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His Gln 
            100                 105                 110         


Ser Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys Glu 
        115                 120                 125             


Cys Arg Pro Lys Lys Asp Lys Ala Arg Gln Glu Asn Pro Cys Gly Pro 
    130                 135                 140                 


Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys 
145                 150                 155                 160 


Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu 
                165                 170                 175     


Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
            180                 185                 190 


<210>  50
<211>  153
<212>  PRT
<213>  Bos taurus

<400>  50

Ala Pro Glu Ser Ile Phe Asp Lys Ile Tyr Ser Thr Lys Ser Asp Val 
1               5                   10                  15      


Trp Ser Tyr Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly Ser 
            20                  25                  30          


Pro Tyr Pro Gly Val Gln Met Asp Glu Asp Phe Cys Ser Arg Leu Lys 
        35                  40                  45              


Asp Gly Met Arg Met Arg Ala Pro Glu Tyr Ala Thr Pro Glu Ile Tyr 
    50                  55                  60                  


Gln Ile Met Leu Asp Cys Trp His Lys Asp Pro Lys Glu Arg Pro Arg 
65                  70                  75                  80  


Phe Val Glu Leu Val Glu Lys Leu Gly Asp Leu Leu Gln Ala Asn Val 
                85                  90                  95      


Gln Gln Asp Gly Lys Asp Tyr Ile Pro Leu Asn Ala Ile Leu Thr Gly 
            100                 105                 110         


Asn Thr Ala Phe Thr Tyr Ser Thr Pro Ala Phe Ser Glu Asp Phe Phe 
        115                 120                 125             


Gln Glu Asp Ile Ser Ala Pro Lys Phe Asn Ser Gly Ser Ser Asp Asn 
    130                 135                 140                 


Val Arg Tyr Val Asn Ala Phe Asn Phe 
145                 150             


<210>  51
<211>  155
<212>  PRT
<213>  Bos taurus

<400>  51

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              


Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys 
                85                  90                  95      


Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Ser Ser Trp Tyr Val Ala Leu Lys 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Leu Gly Pro Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155 


<210>  52
<211>  155
<212>  PRT
<213>  Oreochromis niloticus

<400>  52

Met Ala Thr Gly Gly Ile Thr Thr Leu Pro Ala Thr Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Ser Gly Phe Pro Pro Gly Asn Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile Lys Ser Asp Gly Gly 
        35                  40                  45              


Val Asp Gly Ile Arg Glu Lys Asn Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Thr Ser Val Gly Glu Val Val Ile Lys Gly Ile Cys Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Asn Arg Asp Gly Arg Leu Phe Gly Ala Arg Arg 
                85                  90                  95      


Ala Thr Asp Glu Cys Tyr Phe Leu Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Pro Asn Met Tyr Val Ala Leu Lys 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Ser Gly Ser Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Cys 
145                 150                 155 


<210>  53
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- IGF-1_LR3

<400>  53

Met Phe Pro Ala Met Pro Leu Ser Ser Leu Phe Val Asn Gly Pro Arg 
1               5                   10                  15      


Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 
            20                  25                  30          


Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 
        35                  40                  45              


Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser 
    50                  55                  60                  


Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 
65                  70                  75                  80  


Lys Ser Ala 
            


<210>  54
<211>  499
<212>  PRT
<213>  Bos taurus

<400>  54

Met Glu Ala Ala Ala Ala Thr Pro Arg Pro Arg Leu Phe Leu Leu Met 
1               5                   10                  15      


Leu Ala Ala Ala Ala Thr Leu Val Pro Glu Ala Thr Pro Leu Gln Cys 
            20                  25                  30          


Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly 
        35                  40                  45              


Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn 
    50                  55                  60                  


Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe 
65                  70                  75                  80  


Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Ile Thr Thr Thr Tyr Cys 
                85                  90                  95      


Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro Thr Val Gly Lys 
            100                 105                 110         


Pro Ser Ser Gly Leu Gly Pro Val Glu Leu Ala Ala Val Ile Ala Gly 
        115                 120                 125             


Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met Val Tyr Ile Cys 
    130                 135                 140                 


His Asn Arg Thr Val Ile His His Arg Val Pro Asn Glu Glu Asp Pro 
145                 150                 155                 160 


Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr Leu Lys Asp Leu 
                165                 170                 175     


Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly Leu Pro Leu Leu 
            180                 185                 190         


Val Gln Arg Thr Ile Ala Arg Thr Ile Val Leu Gln Glu Ser Ile Gly 
        195                 200                 205             


Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp Arg Gly Glu Glu 
    210                 215                 220                 


Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg Ser Trp Phe Arg 
225                 230                 235                 240 


Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His Glu Asn Ile Leu 
                245                 250                 255     


Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr Trp Thr Gln Leu 
            260                 265                 270         


Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu Phe Asp Tyr Leu 
        275                 280                 285             


Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys Leu Ala Leu Ser 
    290                 295                 300                 


Thr Ala Ser Gly Leu Ala His Leu His Met Glu Ile Val Gly Thr Gln 
305                 310                 315                 320 


Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile Leu 
                325                 330                 335     


Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu Gly Leu Ala Val 
            340                 345                 350         


Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala Pro Asn His Arg 
        355                 360                 365             


Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Asp Ser Ile 
    370                 375                 380                 


Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Asp Ile Tyr Ala Met 
385                 390                 395                 400 


Gly Leu Val Phe Trp Glu Val Ala Arg Arg Cys Ser Ile Gly Gly Ile 
                405                 410                 415     


His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val Pro Ser Asp Pro 
            420                 425                 430         


Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln Lys Leu Arg Pro 
        435                 440                 445             


Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu Arg Val Met Ala 
    450                 455                 460                 


Lys Ile Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala Ala Arg Leu Thr 
465                 470                 475                 480 


Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser Gln Gln Glu Gly 
                485                 490                 495     


Ile Lys Met 
            


<210>  55
<211>  221
<212>  PRT
<213>  Oreochromis mossambicus

<400>  55

His His Arg Val Pro Asn Glu Glu Asp Pro Ser Met Asp His Pro Phe 
1               5                   10                  15      


Ile Thr Val Gly Thr Thr Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr 
            20                  25                  30          


Ser Gly Ser Gly Ser Gly Leu Pro Leu Leu Val Gln Arg Thr Ile Ala 
        35                  40                  45              


Arg Thr Ile Ile Leu Gln Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu 
    50                  55                  60                  


Val Trp Arg Gly Lys Trp Arg Gly Glu Glu Val Ala Val Lys Ile Phe 
65                  70                  75                  80  


Ser Ser Arg Glu Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln 
                85                  90                  95      


Thr Val Met Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp 
            100                 105                 110         


Asn Lys Asp Asn Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr 
        115                 120                 125             


His Glu His Gly Ser Leu Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr 
    130                 135                 140                 


Val Glu Gly Met Ile Lys Leu Ser Leu Ser Thr Ala Ser Gly Leu Ala 
145                 150                 155                 160 


His Leu His Met Glu Ile Val Gly Thr Gln Gly Lys Pro Ala Ile Ala 
                165                 170                 175     


His Arg Asp Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Thr 
            180                 185                 190         


Cys Cys Ile Ala Asp Leu Gly Leu Ala Val Arg His Asp Ser Ala Thr 
        195                 200                 205             


Asp Thr Ile Asp Ile Ala Pro Asn His Arg Val Gly Thr 
    210                 215                 220     


<210>  56
<211>  118
<212>  PRT
<213>  Bos taurus


<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa can be any naturally occurring amino acid

<400>  56

Glu Ser Ala Gly Glu Cys Cys Ser Cys Pro Lys Thr Asp Ser Gln Ile 
1               5                   10                  15      


Leu Lys Glu Leu Glu Glu Ser Ser Phe Arg Lys Thr Phe Glu Asp Tyr 
            20                  25                  30          


Leu His Asn Val Val Phe Ile Pro Arg Pro Ser Arg Lys Arg Arg Ala 
        35                  40                  45              


Leu Gly Asp Val Gly Asn Val Thr Ala Ala Val Pro Thr Ala Leu Gly 
    50                  55                  60                  


Leu Pro Asn Thr Ser Ser Thr Ser Thr Pro Met Ser Ser Glu Glu His 
65                  70                  75                  80  


Arg Pro Phe Glu Lys Val Val Asn Xaa Glu Ser Leu Val Ile Ser Gly 
                85                  90                  95      


Leu Arg His Phe Thr Gly Tyr Arg Ile Glu Leu Gln Ala Cys Asn Gln 
            100                 105                 110         


Asp Ser Pro Glu Glu Arg 
        115             


<210>  57
<211>  146
<212>  PRT
<213>  Oreochromis niloticus

<400>  57

Phe Gly Met Val Tyr Glu Gly Ile Ala Lys Asp Ile Val Lys Gly Glu 
1               5                   10                  15      


Gly Glu Thr Arg Val Ala Val Lys Thr Val Asn Glu Ser Ala Ser Leu 
            20                  25                  30          


Arg Glu Arg Ile Glu Phe Leu Asn Glu Ala Ser Val Met Lys Ala Phe 
        35                  40                  45              


Ser Cys His His Val Val Arg Leu Leu Gly Val Val Ser Lys Gly Gln 
    50                  55                  60                  


Pro Thr Leu Val Val Met Glu Leu Met Thr His Gly Asp Leu Lys Ser 
65                  70                  75                  80  


Phe Leu Arg Ser Leu Arg Pro Asp Ala Glu Asn Asn Pro Gly Arg Pro 
                85                  90                  95      


Pro Pro Thr Leu Lys Glu Met Ile Gln Met Ala Ala Glu Ile Ala Asp 
            100                 105                 110         


Gly Met Ala Tyr Leu Asn Ala Lys Lys Phe Val His Arg Asp Leu Ala 
        115                 120                 125             


Ala Arg Asn Cys Met Val Ala His Asp Leu Thr Val Lys Met Gly Asp 
    130                 135                 140                 


Leu Glu 
145     


<210>  58
<211>  486
<212>  PRT
<213>  Bos taurus

<400>  58

Met Phe Pro Lys Glu Thr Thr Trp Asn Ile Ser Phe Ala Gly Cys Gly 
1               5                   10                  15      


Phe Leu Gly Val Tyr His Ile Gly Val Ala Ser Cys Leu Arg Glu His 
            20                  25                  30          


Ala Pro Phe Leu Val Ala Asn Ala Thr His Ile Tyr Gly Ala Ser Ala 
        35                  40                  45              


Gly Ala Leu Thr Ala Thr Ala Leu Val Thr Gly Ala Cys Leu Gly Glu 
    50                  55                  60                  


Ala Gly Ala Asn Ile Ile Glu Val Ser Lys Glu Ala Arg Lys Arg Phe 
65                  70                  75                  80  


Leu Gly Pro Leu His Pro Ser Phe Asn Met Val Lys Thr Ile Arg Gly 
                85                  90                  95      


Cys Leu Leu Lys Ile Leu Pro Ala Asp Cys Tyr Glu Cys Ala Ser Gly 
            100                 105                 110         


Arg Leu Gly Ile Ser Leu Thr Arg Val Ser Asp Gly Glu Asn Val Ile 
        115                 120                 125             


Ile Thr His Phe Asn Ser Lys Glu Glu Leu Ile Gln Ala Asn Val Cys 
    130                 135                 140                 


Ser Thr Phe Ile Pro Val Tyr Cys Gly Leu Ile Pro Pro Ser Leu Gln 
145                 150                 155                 160 


Gly Val Arg Tyr Val Asp Gly Gly Ile Ser Asp Asn Leu Pro Leu Tyr 
                165                 170                 175     


Glu Leu Lys Asn Thr Ile Thr Val Ser Pro Phe Ser Gly Glu Ser Asp 
            180                 185                 190         


Ile Cys Pro Gln Asp Ser Ser Thr Asn Ile His Glu Leu Arg Val Thr 
        195                 200                 205             


Asn Thr Ser Ile Gln Phe Asn Leu Arg Asn Leu Tyr Arg Leu Ser Lys 
    210                 215                 220                 


Ala Leu Phe Pro Pro Glu Pro Leu Val Leu Arg Glu Met Cys Lys Gln 
225                 230                 235                 240 


Gly Tyr Arg Asp Gly Leu Arg Phe Leu Arg Arg Asn Gly Leu Leu Asn 
                245                 250                 255     


Arg Pro Asn Pro Leu Leu Ala Leu Pro Pro Ser Gln Pro Pro Ala Pro 
            260                 265                 270         


Glu Asp Ala Asp Ala Gln Glu Gly Ala Val Ala Met Glu Arg Thr Gly 
        275                 280                 285             


Gly Lys Asp His Leu Pro Pro Pro Arg Glu Asp His Ile Leu Glu His 
    290                 295                 300                 


Leu Pro Ser Arg Leu Asn Glu Ala Leu Leu Glu Ala Cys Met Glu Pro 
305                 310                 315                 320 


Thr Asp Leu Leu Thr Thr Leu Ser Asn Met Leu Pro Val Arg Leu Ala 
                325                 330                 335     


Met Ala Met Met Val Pro Tyr Thr Leu Pro Leu Glu Ser Ala Val Ser 
            340                 345                 350         


Phe Thr Ile Arg Leu Leu Glu Trp Leu Pro Asp Val Pro Glu Asp Ile 
        355                 360                 365             


Arg Trp Met Lys Glu Gln Thr Gly Ser Ile Cys Gln Tyr Leu Met Ile 
    370                 375                 380                 


Arg Ala Lys Arg Lys Leu Gly Asn His Leu Pro Ser Arg Leu Ser Gly 
385                 390                 395                 400 


Gln Val Val Leu Arg Arg Ala Arg Ser Leu Pro Ser Val Pro Leu Ser 
                405                 410                 415     


Cys Ala Ala Tyr Ser Glu Val Leu Pro Ser Trp Met Arg Asn Ser Leu 
            420                 425                 430         


Ser Leu Gly Asp Val Leu Ala Lys Trp Glu Glu Cys Gln Arg Gln Leu 
        435                 440                 445             


Leu Leu Gly Leu Phe Cys Thr Asn Val Ala Phe Pro Pro Asp Ala Leu 
    450                 455                 460                 


Arg Met Arg Val Pro Ala Gly Pro Ala Pro Glu Pro Pro Gln His Pro 
465                 470                 475                 480 


Pro Ser Ser Pro Pro Cys 
                485     


<210>  59
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Mechanogrowth factor

<400>  59

Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys 
1               5                   10                  15      


Gly Ser Thr Phe Gln Gln Arg Lys 
            20                  


<210>  60
<211>  390
<212>  PRT
<213>  Bos taurus

<400>  60

Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Met Leu Thr Pro Gly Arg Pro Val Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Asp Val Pro Pro Gly Pro Leu Pro Glu Ala Ile Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Thr Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Tyr Gly Asn Lys Ile Tyr Asp Lys Met Lys Ser Ser Ser 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Asp Val Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Thr Arg Arg Glu Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Lys Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Ser 
225                 230                 235                 240 


Ser Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu His 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  61
<211>  381
<212>  PRT
<213>  Oreochromis niloticus

<400>  61

Met Lys Leu Trp Phe Leu Ile Leu Met Val Val Tyr Met Val Gly Ser 
1               5                   10                  15      


Val His Asn Leu Ser Thr Cys Asn Thr Val Asp Leu Glu Met Val Lys 
            20                  25                  30          


Lys Lys Arg Ile Glu Ala Ile Arg Ser Gln Ile Leu Thr Lys Leu Arg 
        35                  40                  45              


Leu Gln Lys Ala Pro Asp Glu Ala Gly Glu Lys Glu Glu Ile Pro Ala 
    50                  55                  60                  


Asn Leu Leu Ser Leu Tyr Asn Ser Thr Ser Glu Ile Leu Leu Glu Lys 
65                  70                  75                  80  


Gln Asp Glu Glu Gln Lys Ile Ile Pro Arg Glu Gln Glu Glu Glu Glu 
                85                  90                  95      


Tyr Phe Ala Lys Val Leu Asn Arg Phe Asn Met Thr Thr Lys Asn Asp 
            100                 105                 110         


Thr Asn Ile Asn Tyr Lys Pro Lys Val Ile Ser Met Ser Phe Asn Ile 
        115                 120                 125             


Ser Glu Ile Arg Ser Asn Val Gly Asp Gly Leu Leu Leu Thr Arg Ala 
    130                 135                 140                 


Glu Leu Arg Met Leu Ile Lys Glu Pro Met Ile Leu Asn Glu Glu Arg 
145                 150                 155                 160 


Val Glu Leu Tyr His Ser Gln Gly Thr Ser Thr His Tyr Leu Ala Ser 
                165                 170                 175     


Arg Phe Val Thr Asn Thr Leu Lys Asp Lys Trp Leu Ser Phe Asp Val 
            180                 185                 190         


Thr Glu Pro Leu Gln Thr Trp Leu Gln Gly Asn Glu Asn Glu Gln Lys 
        195                 200                 205             


Phe Glu Leu Arg Arg Tyr Cys Glu Cys Gly Asn Asn Asp Asp Thr Leu 
    210                 215                 220                 


Ser Phe Ser Ile Ser Gly Thr Met Ser Arg Arg Gly Asp Thr Lys Asp 
225                 230                 235                 240 


Leu Gln Lys Leu Asn Gln Gln Leu Pro Tyr Ile Phe Thr Met Ser Ile 
                245                 250                 255     


Pro Lys Thr Asn His Ser Lys Ser Leu Arg Thr Lys Arg Ser Thr Asp 
            260                 265                 270         


Thr Thr Asp Ser Cys Gly Thr Gln Ser His Asn Cys Cys Leu Lys Lys 
        275                 280                 285             


Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp Ile His Lys 
    290                 295                 300                 


Pro Thr Gly Tyr Tyr Ala Asn Tyr Cys Met Gly Ser Cys Thr Tyr Ile 
305                 310                 315                 320 


Trp Asp Ala Glu Asn Lys Tyr Ser Gln Ile Leu Ala Leu Tyr Lys His 
                325                 330                 335     


His Asn Pro Gly Ala Ser Ala Gln Pro Cys Cys Ala Pro Gln Thr Leu 
            340                 345                 350         


Glu Pro Leu Pro Ile Ile Tyr Tyr Val Gly Arg Gln His Lys Val Glu 
        355                 360                 365             


Gln Leu Ser Asn Met Ile Val Thr Ser Cys Lys Cys Ser 
    370                 375                 380     


<210>  62
<211>  414
<212>  PRT
<213>  Bos taurus

<400>  62

Met His Tyr Cys Val Leu Ser Ala Phe Leu Leu Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Ser Phe Leu 
            100                 105                 110         


Pro Ser Glu Asn Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg 
        115                 120                 125             


Ile Val Arg Phe Asp Val Ser Ser Met Glu Lys Asn Ala Ser Asn Leu 
    130                 135                 140                 


Val Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg 
145                 150                 155                 160 


Val Pro Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp 
                165                 170                 175     


Leu Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr 
            180                 185                 190         


Arg Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His 
        195                 200                 205             


Glu Trp Leu His His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu 
    210                 215                 220                 


His Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro 
225                 230                 235                 240 


Asn Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr 
                245                 250                 255     


Ser Thr Tyr Thr Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys 
            260                 265                 270         


Lys Asn Ser Gly Lys Ser Pro His Leu Leu Leu Met Leu Leu Pro Ser 
        275                 280                 285             


Tyr Arg Leu Glu Ser Gln Gln Ser Asn Arg Arg Lys Lys Arg Ala Leu 
    290                 295                 300                 


Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg 
305                 310                 315                 320 


Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His 
                325                 330                 335     


Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr 
            340                 345                 350         


Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn 
        355                 360                 365             


Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp 
    370                 375                 380                 


Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile 
385                 390                 395                 400 


Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                405                 410                 


<210>  63
<211>  407
<212>  PRT
<213>  Oreochromis niloticus

<400>  63

Met Asn Val Tyr Leu Val Cys Leu Phe Leu Thr Leu Asp Leu Ala Thr 
1               5                   10                  15      


Val Ala Phe Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Lys Lys Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Ala Ala Pro Pro Lys Asp Phe Pro Glu Pro Glu Glu Val Ser 
    50                  55                  60                  


Arg Asp Ile Val Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Asn Glu Arg Ala Ala Thr Cys Glu Arg Gln Arg Ser Glu Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val His Lys Ile Asp Met Gln Pro Val His 
            100                 105                 110         


Ser Pro Glu Asn Val Ile Ser Pro Thr Pro Phe Asn Pro Tyr Phe Arg 
        115                 120                 125             


Trp Leu Thr Phe Asp Val Ser Ser Met Glu Lys Asn Ala Ser Asn Leu 
    130                 135                 140                 


Val Lys Ala Glu Leu Arg Ile Phe Arg Leu Gln Asn Pro Gly Ala Arg 
145                 150                 155                 160 


Val Ser Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Gly Tyr Lys Gly 
                165                 170                 175     


Leu Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Ile Arg Thr 
            180                 185                 190         


Gln Thr Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Glu Ala Val Ser 
        195                 200                 205             


Glu Trp Leu Asn His Arg Asp Arg Asn Ser Gly Phe Lys Ile Ser Leu 
    210                 215                 220                 


His Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro 
225                 230                 235                 240 


Asn Asn Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Asp Asn 
                245                 250                 255     


Leu Ile His Gly Arg Asp Leu Lys Val Phe Arg Lys Trp Gln His Ser 
            260                 265                 270         


Val Arg Gly Pro His Leu Leu Leu Met Leu Leu Pro Ser Tyr Arg Leu 
        275                 280                 285             


Glu Ser Gln Ser Gln His Lys Asn His Arg Ser Lys Arg Ala Leu Asp 
    290                 295                 300                 


Thr Ala Tyr Cys Ser Lys Asn Val Gln Asp Asn Cys Cys Leu Arg Ser 
305                 310                 315                 320 


Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Arg Trp Ile His Glu 
                325                 330                 335     


Pro Lys Gly Tyr Glu Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr Leu 
            340                 345                 350         


Trp Ser Ala Asp Thr Gln His Ser Lys Val Leu Gly Leu Tyr Asn Thr 
        355                 360                 365             


Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp Leu 
    370                 375                 380                 


Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile Glu 
385                 390                 395                 400 


Gln Leu Ser Asn Met Lys Asn 
                405         


<210>  64
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- puromycin resistance

<400>  64

Met Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp Asp Val 
1               5                   10                  15      


Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr Pro Ala 
            20                  25                  30          


Thr Arg His Thr Val Asp Pro Asp Arg His Ile Glu Arg Val Thr Glu 
        35                  40                  45              


Leu Gln Glu Leu Phe Leu Thr Arg Val Gly Leu Asp Ile Gly Lys Val 
    50                  55                  60                  


Trp Val Ala Asp Asp Gly Ala Ala Val Ala Val Trp Thr Thr Pro Glu 
65                  70                  75                  80  


Ser Val Glu Ala Gly Ala Val Phe Ala Glu Ile Gly Pro Arg Met Ala 
                85                  90                  95      


Glu Leu Ser Gly Ser Arg Leu Ala Ala Gln Gln Gln Met Glu Gly Leu 
            100                 105                 110         


Leu Ala Pro His Arg Pro Lys Glu Pro Ala Trp Phe Leu Ala Thr Val 
        115                 120                 125             


Gly Val Ser Pro Asp His Gln Gly Lys Gly Leu Gly Ser Ala Val Val 
    130                 135                 140                 


Leu Pro Gly Val Glu Ala Ala Glu Arg Ala Gly Val Pro Ala Phe Leu 
145                 150                 155                 160 


Glu Thr Ser Ala Pro Arg Asn Leu Pro Phe Tyr Glu Arg Leu Gly Phe 
                165                 170                 175     


Thr Val Thr Ala Asp Val Glu Val Pro Glu Gly Pro Arg Thr Trp Cys 
            180                 185                 190         


Met Thr Arg Lys Pro Gly Ala 
        195                 


<210>  65
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- GFP

<400>  65

Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Arg 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210>  66
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- T2A peptide

<400>  66

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  67
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- P2A peptide

<400>  67

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  68
<211>  142
<212>  PRT
<213>  Bos taurus

<400>  68

Ile Asp Glu Cys Arg Arg Gly Val His Ser Cys Gly Glu Asn Ala Thr 
1               5                   10                  15      


Cys Thr Asn Met Glu Gly Asn His Thr Cys Thr Cys Ala Gly Asp Leu 
            20                  25                  30          


Ser Glu Pro Gly Gln Ile Cys Pro Asp Ser Thr Leu Leu Ser His Leu 
        35                  40                  45              


Gly Lys Asn Gly His Asn Phe Leu Lys Lys Cys Phe Pro Glu Tyr Thr 
    50                  55                  60                  


Pro Asn Phe Glu Gly Tyr Cys Leu Asn Gly Arg Val Cys Ile Tyr Phe 
65                  70                  75                  80  


Gly Ile Ala Asn Leu Phe Ser Cys His Cys Pro Ile Gly Tyr Pro Gly 
                85                  90                  95      


Lys Arg Gly Glu Tyr Ile Asp Phe Asp Gly Trp Asp Pro His Ser Ala 
            100                 105                 110         


Gly Arg Gly His Gln Trp Asn Thr Ser Pro Val Ala Val Arg Ala Leu 
        115                 120                 125             


Val Leu Ala Phe Leu Leu Leu Leu Gly Leu Cys Arg Ala His 
    130                 135                 140         


<210>  69
<211>  1200
<212>  PRT
<213>  Bos taurus

<400>  69

Met Arg Leu Ser Gly Ala Gly Arg Ala Ala Leu Leu Val Leu Leu Ala 
1               5                   10                  15      


Ala His Phe Gln Thr Ser Leu Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Met Gln Ser Ser Tyr Asn Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Lys Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Val Leu 
            100                 105                 110         


Tyr Glu Asn Thr His Ala Leu Ala Val Leu Ser Asn Tyr Gly Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Arg Glu Leu Pro Leu Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


Gln Gly Ala Val Arg Phe Ser Asn Asn Pro Val Leu Cys Asn Val Glu 
145                 150                 155                 160 


Thr Ile Gln Trp Arg Asp Ile Val Asn Pro Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Thr Gly Asp Phe Gln Asn Gln Gln Gly Asn Cys Pro Lys Cys Asp Pro 
            180                 185                 190         


Ala Cys Leu Asn Arg Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Arg Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Arg Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asp Pro 
            260                 265                 270         


Thr Thr Tyr Glu Met Lys Val Asn Pro Leu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Ser Ser Asp Ser Gln Glu Val Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Asp Gly Pro Cys Gly Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Thr Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Arg Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr Arg Thr 
    370                 375                 380                 


Ala Pro Leu Asp Pro Lys Glu Leu Asp Ile Leu Arg Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Gly Leu Asp Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Arg Asn Leu Cys Tyr Ala Asp Thr Ile Arg Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Thr Gln Lys Thr Lys Ile Leu Asn Asn Arg Ser Glu 
                485                 490                 495     


Lys Gln Cys Lys Ala Ala Gly His Ile Cys His Pro Leu Cys Ser Ser 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Gly Pro Lys Tyr Cys Met Ser Cys Gln Asn 
        515                 520                 525             


Phe Ser Arg Gly Lys Glu Cys Val Gly Lys Cys Asn Ile Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Val Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Val Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Gly Asn Cys Val Lys Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Ala Gly Glu Asn Gly Thr Leu Ile Trp 
        595                 600                 605             


Lys Phe Ala Asp Ala Asn His Val Cys Leu Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Glu Gly Pro Gly Leu Glu Gly Cys Pro Gln Lys Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Ile Val Gly Gly Leu Leu Leu 
                645                 650                 655     


Val Val Val Leu Ala Leu Ser Val Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Val Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Val Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Thr Val Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Leu Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Glu 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Val Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe His  Ser Pro Thr Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Thr  Ser Ser Asn Thr Pro  Thr Val Thr Cys Val  Asp Arg Asn 
    1040                 1045                 1050             


Gly Ser  Tyr Pro Leu Lys Glu  Asp Ser Phe Leu Gln  Arg Tyr Ser 
    1055                 1060                 1065             


Ser Asp  Pro Thr Gly Ala Leu  Ile Glu Asp Ser Met  Asp Asp Thr 
    1070                 1075                 1080             


Phe Leu  Pro Val Pro Glu Tyr  Val Asn Gln Ser Val  Pro Lys Arg 
    1085                 1090                 1095             


Pro Ala  Gly Ser Val Gln Asn  Pro Val Tyr His Asn  Gln Pro Leu 
    1100                 1105                 1110             


Tyr Pro  Ala Pro Gly Arg Asp  Pro Gln Tyr Gln Asn  Ser Leu Ser 
    1115                 1120                 1125             


Asn Ala  Val Asp Asn Pro Glu  Tyr Leu Asn Thr Thr  His Pro Ala 
    1130                 1135                 1140             


Cys Ile  Asn Gly Val Leu Asp  Gly Pro Ala Leu Trp  Ala Gln Lys 
    1145                 1150                 1155             


Gly Ser  His Gln Phe Ser Leu  Asp Asn Pro Asp Tyr  Gln Gln Ala 
    1160                 1165                 1170             


Phe Phe  Pro Lys Glu Ala Lys  Ser Asn Gly Ile Phe  Lys Gly Pro 
    1175                 1180                 1185             


Ala Ala  Glu Asn Ala Glu Tyr  Leu Arg Ala Ala Pro  
    1190                 1195                 1200 


<210>  70
<211>  154
<212>  PRT
<213>  Bos taurus

<400>  70

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Gln Val Lys Met Pro Ile Thr Ser Ser Ser His 
            20                  25                  30          


Leu Phe Tyr Leu Ala Leu Cys Leu Leu Ala Phe Thr Ser Ser Ala Thr 
        35                  40                  45              


Ala Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln 
    50                  55                  60                  


Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr 
65                  70                  75                  80  


Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys 
                85                  90                  95      


Cys Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro 
            100                 105                 110         


Leu Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr 
        115                 120                 125             


Asp Met Pro Lys Ala Gln Lys Glu Val His Leu Lys Asn Thr Ser Arg 
    130                 135                 140                 


Gly Ser Ala Gly Asn Lys Asn Tyr Arg Met 
145                 150                 


<210>  71
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Ile Pro Gly Asn Arg Met Leu Met Val Val Leu Leu Cys Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ser His Ala Ser Leu Ile Pro Glu Thr Gly Lys 
            20                  25                  30          


Lys Lys Val Ala Glu Ile Gln Gly His Ala Gly Gly Arg Arg Ser Gly 
        35                  40                  45              


Gln Ser His Glu Leu Leu Arg Asp Phe Glu Ala Thr Leu Leu Gln Met 
    50                  55                  60                  


Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile Pro 
65                  70                  75                  80  


Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu Glu 
                85                  90                  95      


Glu Gln Ile His Ser Thr Gly Leu Glu Tyr Pro Glu Arg Pro Ala Ser 
            100                 105                 110         


Arg Ala Asn Thr Val Arg Ser Phe His His Glu Glu His Leu Glu Asn 
        115                 120                 125             


Ile Pro Gly Thr Ser Glu Asn Ser Ala Phe Arg Phe Leu Phe Asn Leu 
    130                 135                 140                 


Ser Ser Ile Pro Glu Asn Glu Val Ile Ser Ser Ala Glu Leu Arg Leu 
145                 150                 155                 160 


Phe Arg Glu Gln Val Asp Gln Gly Pro Asp Trp Glu Arg Gly Phe His 
                165                 170                 175     


Arg Ile Asn Ile Tyr Glu Val Met Lys Pro Pro Ala Glu Val Val Pro 
            180                 185                 190         


Gly His Leu Ile Thr Arg Leu Leu Asp Thr Arg Leu Val His His Asn 
        195                 200                 205             


Val Thr Arg Trp Glu Thr Phe Asp Val Ser Pro Ala Val Leu Arg Trp 
    210                 215                 220                 


Thr Arg Glu Lys Gln Pro Asn Tyr Gly Leu Ala Ile Glu Val Thr His 
225                 230                 235                 240 


Leu His Gln Thr Arg Thr His Gln Gly Gln His Val Arg Ile Ser Arg 
                245                 250                 255     


Ser Leu Pro Gln Gly Ser Gly Asn Trp Ala Gln Leu Arg Pro Leu Leu 
            260                 265                 270         


Val Thr Phe Gly His Asp Gly Arg Gly His Ala Leu Thr Arg Arg Arg 
        275                 280                 285             


Arg Ala Lys Arg Ser Pro Lys His His Ser Gln Arg Ala Arg Lys Lys 
    290                 295                 300                 


Asn Lys Asn Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val 
305                 310                 315                 320 


Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr 
                325                 330                 335     


Cys His Gly Asp Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr 
            340                 345                 350         


Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Ser Ile 
        355                 360                 365             


Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
    370                 375                 380                 


Tyr Leu Asp Glu Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln Glu Met 
385                 390                 395                 400 


Val Val Glu Gly Cys Gly Cys Arg 
                405             


<210>  72
<211>  409
<212>  PRT
<213>  Bos taurus

<400>  72

Met Ile Pro Gly Asn Arg Met Leu Met Val Val Leu Leu Cys Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ser His Ala Ser Leu Ile Pro Glu Thr Gly Lys 
            20                  25                  30          


Lys Lys Val Ala Glu Ile Gln Gly His Ala Gly Gly Arg Arg Ser Gly 
        35                  40                  45              


Gln Ser His Glu Leu Leu Arg Asp Phe Glu Ala Thr Leu Leu Gln Met 
    50                  55                  60                  


Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile Pro 
65                  70                  75                  80  


Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu Glu 
                85                  90                  95      


Glu Glu Gln Ile Gln Gly Ile Gly Leu Glu Tyr Pro Glu Arg Pro Ala 
            100                 105                 110         


Ser Arg Ala Asn Thr Val Arg Ser Phe His His Glu Glu His Leu Glu 
        115                 120                 125             


Asn Ile Pro Gly Thr Ser Glu Asn Ser Ala Phe Arg Phe Leu Phe Asn 
    130                 135                 140                 


Leu Ser Ser Ile Pro Glu Asn Glu Val Ile Ser Ser Ala Glu Leu Arg 
145                 150                 155                 160 


Leu Phe Arg Glu Gln Val Asp Gln Gly Pro Asp Trp Asp Gln Gly Phe 
                165                 170                 175     


His Arg Ile Asn Ile Tyr Glu Val Met Lys Pro Pro Ala Glu Val Val 
            180                 185                 190         


Pro Gly His Leu Ile Thr Arg Leu Leu Asp Thr Arg Leu Val His His 
        195                 200                 205             


Asn Val Thr Arg Trp Glu Thr Phe Asp Val Ser Pro Ala Val Leu Arg 
    210                 215                 220                 


Trp Thr Arg Glu Lys Gln Pro Asn Tyr Gly Leu Ala Ile Glu Val Thr 
225                 230                 235                 240 


His Leu His Gln Thr Arg Thr His Gln Gly Gln His Val Arg Ile Ser 
                245                 250                 255     


Arg Ser Leu Pro Gln Gly Ser Gly Asp Trp Ala Gln Leu Arg Pro Leu 
            260                 265                 270         


Leu Val Thr Phe Gly His Asp Gly Arg Gly His Ala Leu Thr Arg Arg 
        275                 280                 285             


Arg Arg Ala Lys Arg Ser Pro Lys His His Pro Gln Arg Ala Arg Lys 
    290                 295                 300                 


Lys Asn Lys Asn Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp 
305                 310                 315                 320 


Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe 
                325                 330                 335     


Tyr Cys His Gly Asp Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser 
            340                 345                 350         


Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Ser 
        355                 360                 365             


Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met 
    370                 375                 380                 


Leu Tyr Leu Asp Glu Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln Glu 
385                 390                 395                 400 


Met Val Val Glu Gly Cys Gly Cys Arg 
                405                 


<210>  73
<211>  505
<212>  PRT
<213>  Bos taurus

<400>  73

Met Gly Glu Thr Leu Gly Asp Ala Leu Ile Asp Pro Glu Ser Glu Pro 
1               5                   10                  15      


Phe Ala Val Thr Val Ser Ala Arg Thr Ser Gln Glu Ile Thr Met Val 
            20                  25                  30          


Asp Thr Glu Met Pro Phe Trp Pro Thr Asn Phe Gly Ile Ser Ser Val 
        35                  40                  45              


Asp Leu Ser Met Met Asp Asp His Ser His Ala Phe Asp Ile Lys Pro 
    50                  55                  60                  


Phe Thr Thr Val Asp Phe Ser Ser Ile Ser Thr Pro His Tyr Glu Asp 
65                  70                  75                  80  


Ile Pro Phe Pro Arg Ala Asp Pro Met Val Ala Asp Tyr Lys Tyr Asp 
                85                  90                  95      


Leu Lys Leu Gln Glu Tyr Gln Ser Ala Ile Lys Val Glu Pro Val Ser 
            100                 105                 110         


Pro Pro Tyr Tyr Ser Glu Lys Thr Gln Leu Tyr Ser Lys Pro His Glu 
        115                 120                 125             


Glu Pro Ser Asn Ser Leu Met Ala Ile Glu Cys Arg Val Cys Gly Asp 
    130                 135                 140                 


Lys Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys 
145                 150                 155                 160 


Gly Phe Phe Arg Arg Thr Ile Arg Leu Lys Leu Ile Tyr Asp Arg Cys 
                165                 170                 175     


Asp Leu Asn Cys Arg Ile His Lys Lys Ser Arg Asn Lys Cys Gln Tyr 
            180                 185                 190         


Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Ser His Asn Ala Ile 
        195                 200                 205             


Arg Phe Gly Arg Met Pro Gln Ala Glu Lys Glu Lys Leu Leu Ala Glu 
    210                 215                 220                 


Ile Ser Ser Asp Ile Asp Gln Leu Asn Pro Glu Ser Ala Asp Leu Arg 
225                 230                 235                 240 


Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys Ser Phe Pro Leu 
                245                 250                 255     


Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys Thr Thr Asp Lys 
            260                 265                 270         


Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Met Met Gly Glu Asp 
        275                 280                 285             


Lys Ile Lys Phe Lys His Ile Ser Pro Leu Gln Glu Pro Ser Lys Glu 
    290                 295                 300                 


Val Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg Ser Val Glu Ala 
305                 310                 315                 320 


Val Gln Glu Ile Thr Glu Tyr Ala Lys Asn Ile Pro Gly Phe Val Asn 
                325                 330                 335     


Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu 
            340                 345                 350         


Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys Asp Gly Val Leu 
        355                 360                 365             


Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe Leu Lys Ser Leu 
    370                 375                 380                 


Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe Glu Phe Ala Val 
385                 390                 395                 400 


Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Ile Phe Ile 
                405                 410                 415     


Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu Leu Asn Val Lys 
            420                 425                 430         


Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala Leu Glu Leu Gln 
        435                 440                 445             


Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe Ala Lys Leu Leu 
    450                 455                 460                 


Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu His Val Gln Leu 
465                 470                 475                 480 


Leu Gln Val Ile Lys Lys Thr Glu Thr Asp Met Ser Leu His Pro Leu 
                485                 490                 495     


Leu Gln Glu Ile Tyr Lys Asp Leu Tyr 
            500                 505 


<210>  74
<211>  353
<212>  PRT
<213>  Bos taurus

<400>  74

Met Glu Ser Ala Asp Phe Tyr Glu Ala Glu Pro Arg Pro Pro Met Ser 
1               5                   10                  15      


Ser His Leu Gln Ser Pro Pro His Ala Pro Ser Ser Ala Ala Phe Gly 
            20                  25                  30          


Phe Pro Arg Gly Ala Gly Pro Ser Gln Pro Pro Ala Pro Pro Ala Ala 
        35                  40                  45              


Pro Glu Pro Leu Gly Gly Ile Cys Glu His Glu Thr Ser Ile Asp Ile 
    50                  55                  60                  


Ser Ala Tyr Ile Asp Pro Ala Ala Phe Asn Asp Glu Phe Leu Ala Asp 
65                  70                  75                  80  


Leu Phe Gln His Ser Arg Gln Gln Glu Lys Ala Lys Ala Ala Ala Ala 
                85                  90                  95      


Pro Ala Gly Gly Gly Asn Asp Phe Asp Tyr Pro Gly Ala Pro Val Gly 
            100                 105                 110         


Pro Gly Gly Ala Val Met Pro Gly Gly Thr His Gly Pro Pro Pro Gly 
        115                 120                 125             


Tyr Gly Cys Ala Ala Ala Gly Tyr Leu Asp Ser Arg Leu Glu Pro Leu 
    130                 135                 140                 


Tyr Glu Arg Val Gly Ala Pro Ala Leu Arg Pro Leu Val Ile Lys Gln 
145                 150                 155                 160 


Glu Pro Arg Glu Glu Asp Glu Ala Lys Gln Leu Ala Leu Ala Gly Leu 
                165                 170                 175     


Phe Pro Tyr Gln Pro Pro Pro Pro Pro Pro Pro Pro Asn Ser His Pro 
            180                 185                 190         


Pro Pro Ala His Leu Ala Ala Pro His Leu Gln Phe Gln Ile Ala His 
        195                 200                 205             


Cys Gly Gln Thr Thr Met His Leu Gln Pro Gly His Pro Thr Pro Pro 
    210                 215                 220                 


Pro Thr Pro Val Pro Ser Pro His Pro Ala Pro Ala Leu Gly Ala Ala 
225                 230                 235                 240 


Gly Leu Pro Gly Pro Gly Gly Ala Leu Lys Gly Leu Val Ala Thr His 
                245                 250                 255     


Pro Asp Leu Arg Ala Gly Gly Gly Gly Gly Gly Lys Ala Lys Lys Ser 
            260                 265                 270         


Val Asp Lys Asn Ser Asn Glu Tyr Arg Val Arg Arg Glu Arg Asn Asn 
        275                 280                 285             


Ile Ala Val Arg Lys Ser Arg Asp Lys Ala Lys Gln Arg Asn Val Glu 
    290                 295                 300                 


Thr Gln Gln Lys Val Leu Glu Leu Thr Ser Asp Asn Asp Arg Leu Arg 
305                 310                 315                 320 


Lys Arg Val Glu Gln Leu Ser Arg Glu Leu Asp Thr Leu Arg Gly Ile 
                325                 330                 335     


Phe Arg Gln Leu Pro Glu Ser Ser Leu Val Lys Ala Met Gly Asn Cys 
            340                 345                 350         


Ala 
    


<210>  75
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Gly Glu Thr Leu Gly Asp Ser Pro Ile Asp Pro Glu Ser Asp Ser 
1               5                   10                  15      


Phe Thr Asp Thr Leu Ser Ala Asn Ile Ser Gln Glu Met Thr Met Val 
            20                  25                  30          


Asp Thr Glu Met Pro Phe Trp Pro Thr Asn Phe Gly Ile Ser Ser Val 
        35                  40                  45              


Asp Leu Ser Val Met Glu Asp His Ser His Ser Phe Asp Ile Lys Pro 
    50                  55                  60                  


Phe Thr Thr Val Asp Phe Ser Ser Ile Ser Thr Pro His Tyr Glu Asp 
65                  70                  75                  80  


Ile Pro Phe Thr Arg Thr Asp Pro Val Val Ala Asp Tyr Lys Tyr Asp 
                85                  90                  95      


Leu Lys Leu Gln Glu Tyr Gln Ser Ala Ile Lys Val Glu Pro Ala Ser 
            100                 105                 110         


Pro Pro Tyr Tyr Ser Glu Lys Thr Gln Leu Tyr Asn Lys Pro His Glu 
        115                 120                 125             


Glu Pro Ser Asn Ser Leu Met Ala Ile Glu Cys Arg Val Cys Gly Asp 
    130                 135                 140                 


Lys Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys 
145                 150                 155                 160 


Gly Phe Phe Arg Arg Thr Ile Arg Leu Lys Leu Ile Tyr Asp Arg Cys 
                165                 170                 175     


Asp Leu Asn Cys Arg Ile His Lys Lys Ser Arg Asn Lys Cys Gln Tyr 
            180                 185                 190         


Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Ser His Asn Ala Ile 
        195                 200                 205             


Arg Phe Gly Arg Met Pro Gln Ala Glu Lys Glu Lys Leu Leu Ala Glu 
    210                 215                 220                 


Ile Ser Ser Asp Ile Asp Gln Leu Asn Pro Glu Ser Ala Asp Leu Arg 
225                 230                 235                 240 


Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys Ser Phe Pro Leu 
                245                 250                 255     


Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys Thr Thr Asp Lys 
            260                 265                 270         


Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Met Met Gly Glu Asp 
        275                 280                 285             


Lys Ile Lys Phe Lys His Ile Thr Pro Leu Gln Glu Gln Ser Lys Glu 
    290                 295                 300                 


Val Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg Ser Val Glu Ala 
305                 310                 315                 320 


Val Gln Glu Ile Thr Glu Tyr Ala Lys Ser Ile Pro Gly Phe Val Asn 
                325                 330                 335     


Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu 
            340                 345                 350         


Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys Asp Gly Val Leu 
        355                 360                 365             


Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe Leu Lys Ser Leu 
    370                 375                 380                 


Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe Glu Phe Ala Val 
385                 390                 395                 400 


Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Ile Phe Ile 
                405                 410                 415     


Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu Leu Asn Val Lys 
            420                 425                 430         


Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala Leu Glu Leu Gln 
        435                 440                 445             


Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe Ala Lys Leu Leu 
    450                 455                 460                 


Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu His Val Gln Leu 
465                 470                 475                 480 


Leu Gln Val Ile Lys Lys Thr Glu Thr Asp Met Ser Leu His Pro Leu 
                485                 490                 495     


Leu Gln Glu Ile 
            500 


<210>  76
<211>  498
<212>  PRT
<213>  Gallus gallus

<400>  76

Met Val Asp Thr Glu Met Pro Phe Trp Pro Val Asn Phe Gly Ile Ser 
1               5                   10                  15      


Pro Val Asp Leu Ser Ala Met Asp Asp His Met His Ser Phe Asp Ile 
            20                  25                  30          


Lys Pro Phe Thr Thr Val Asp Phe Ser Ser Ile Ser Ser Pro His Tyr 
        35                  40                  45              


Glu Asp Ile Pro Leu Gly Arg Ala Asp Gln Thr Ser Ile Asp Tyr Lys 
    50                  55                  60                  


Tyr Asp Ile Lys Leu Gln Asp Cys Gln Ile Ser Val Glu Lys Lys Ser 
65                  70                  75                  80  


Ser Trp Phe Met Ser Ile Ala Lys Gln Glu Thr Lys His Ser His Tyr 
                85                  90                  95      


Gly Ala Ile Lys Met Glu Pro Pro Ser Pro Pro Tyr Phe Ser Glu Lys 
            100                 105                 110         


Val Gln Leu Tyr Asn Lys Pro His Glu Glu Ser Ser Asn Ser Leu Met 
        115                 120                 125             


Ala Ile Glu Cys Arg Val Cys Gly Asp Lys Ala Ser Gly Phe His Tyr 
    130                 135                 140                 


Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Thr Ile 
145                 150                 155                 160 


Arg Leu Lys Leu Ile Tyr Asp Arg Cys Asp Leu Asn Cys Arg Ile His 
                165                 170                 175     


Lys Lys Ser Arg Asn Lys Cys Gln Tyr Cys Arg Phe Gln Lys Cys Leu 
            180                 185                 190         


Ala Val Gly Met Ser His Asn Ala Ile Arg Phe Gly Arg Met Pro Gln 
        195                 200                 205             


Ala Glu Lys Glu Lys Leu Leu Ala Glu Ile Ser Ser Asp Ile Asp Gln 
    210                 215                 220                 


Leu Asn Pro Glu Ser Ala Asp Leu Arg Ala Leu Ala Lys His Leu Tyr 
225                 230                 235                 240 


Asp Ser Tyr Ile Lys Ser Phe Pro Leu Thr Lys Ala Lys Ala Arg Ala 
                245                 250                 255     


Ile Leu Thr Gly Lys Thr Thr Asp Lys Ser Pro Phe Val Ile Tyr Asp 
            260                 265                 270         


Met Asn Ser Leu Arg Met Gly Glu Asp Gln Ile Lys Cys Lys His Ala 
        275                 280                 285             


Ser Pro Leu Gln Glu Gln Asn Lys Glu Val Ala Ile Arg Ile Phe Gln 
    290                 295                 300                 


Arg Cys Gln Phe Arg Ser Val Glu Ala Val Gln Glu Ile Thr Glu Phe 
305                 310                 315                 320 


Ala Lys Asn Ile Pro Gly Phe Val Asn Leu Asp Leu Asn Asp Gln Val 
                325                 330                 335     


Thr Leu Leu Lys Tyr Gly Val His Glu Ile Ile Tyr Thr Leu Leu Ala 
            340                 345                 350         


Ser Leu Met Asn Lys Asp Gly Val Leu Ile Ser Asp Gly Gln Gly Phe 
        355                 360                 365             


Met Thr Arg Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Cys Asp Phe 
    370                 375                 380                 


Met Glu Pro Lys Phe Glu Phe Ala Val Lys Phe Asn Ala Leu Glu Leu 
385                 390                 395                 400 


Asp Asp Ser Asp Leu Ala Ile Phe Ile Ala Val Ile Ile Leu Ser Gly 
                405                 410                 415     


Asp Arg Pro Gly Leu Leu Asn Val Lys Pro Ile Glu Asp Ile Gln Asp 
            420                 425                 430         


Asn Leu Leu Gln Ala Leu Glu Leu Gln Leu Lys Leu Asn His Pro Glu 
        435                 440                 445             


Ser Ser Gln Leu Phe Ala Lys Leu Leu Gln Lys Met Thr Asp Leu Arg 
    450                 455                 460                 


Gln Ile Val Thr Glu His Val Gln Leu Leu Gln Ile Ile Lys Lys Thr 
465                 470                 475                 480 


Glu Thr Asp Met Ser Leu His Pro Leu Leu Gln Glu Ile Tyr Lys Asp 
                485                 490                 495     


Leu Tyr 
        


<210>  77
<211>  505
<212>  PRT
<213>  Mus musculus

<400>  77

Met Gly Glu Thr Leu Gly Asp Ser Pro Val Asp Pro Glu His Gly Ala 
1               5                   10                  15      


Phe Ala Asp Ala Leu Pro Met Ser Thr Ser Gln Glu Ile Thr Met Val 
            20                  25                  30          


Asp Thr Glu Met Pro Phe Trp Pro Thr Asn Phe Gly Ile Ser Ser Val 
        35                  40                  45              


Asp Leu Ser Val Met Glu Asp His Ser His Ser Phe Asp Ile Lys Pro 
    50                  55                  60                  


Phe Thr Thr Val Asp Phe Ser Ser Ile Ser Ala Pro His Tyr Glu Asp 
65                  70                  75                  80  


Ile Pro Phe Thr Arg Ala Asp Pro Met Val Ala Asp Tyr Lys Tyr Asp 
                85                  90                  95      


Leu Lys Leu Gln Glu Tyr Gln Ser Ala Ile Lys Val Glu Pro Ala Ser 
            100                 105                 110         


Pro Pro Tyr Tyr Ser Glu Lys Thr Gln Leu Tyr Asn Arg Pro His Glu 
        115                 120                 125             


Glu Pro Ser Asn Ser Leu Met Ala Ile Glu Cys Arg Val Cys Gly Asp 
    130                 135                 140                 


Lys Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys 
145                 150                 155                 160 


Gly Phe Phe Arg Arg Thr Ile Arg Leu Lys Leu Ile Tyr Asp Arg Cys 
                165                 170                 175     


Asp Leu Asn Cys Arg Ile His Lys Lys Ser Arg Asn Lys Cys Gln Tyr 
            180                 185                 190         


Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Ser His Asn Ala Ile 
        195                 200                 205             


Arg Phe Gly Arg Met Pro Gln Ala Glu Lys Glu Lys Leu Leu Ala Glu 
    210                 215                 220                 


Ile Ser Ser Asp Ile Asp Gln Leu Asn Pro Glu Ser Ala Asp Leu Arg 
225                 230                 235                 240 


Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys Ser Phe Pro Leu 
                245                 250                 255     


Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys Thr Thr Asp Lys 
            260                 265                 270         


Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Met Met Gly Glu Asp 
        275                 280                 285             


Lys Ile Lys Phe Lys His Ile Thr Pro Leu Gln Glu Gln Ser Lys Glu 
    290                 295                 300                 


Val Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg Ser Val Glu Ala 
305                 310                 315                 320 


Val Gln Glu Ile Thr Glu Tyr Ala Lys Asn Ile Pro Gly Phe Ile Asn 
                325                 330                 335     


Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu 
            340                 345                 350         


Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys Asp Gly Val Leu 
        355                 360                 365             


Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe Leu Lys Asn Leu 
    370                 375                 380                 


Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe Glu Phe Ala Val 
385                 390                 395                 400 


Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Ile Phe Ile 
                405                 410                 415     


Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu Leu Asn Val Lys 
            420                 425                 430         


Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala Leu Glu Leu Gln 
        435                 440                 445             


Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe Ala Lys Val Leu 
    450                 455                 460                 


Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu His Val Gln Leu 
465                 470                 475                 480 


Leu His Val Ile Lys Lys Thr Glu Thr Asp Met Ser Leu His Pro Leu 
                485                 490                 495     


Leu Gln Glu Ile Tyr Lys Asp Leu Tyr 
            500                 505 


<210>  78
<211>  505
<212>  PRT
<213>  Capra hircus

<400>  78

Met Gly Glu Thr Leu Gly Asp Pro Leu Ile Asp Pro Glu Ser Glu Pro 
1               5                   10                  15      


Phe Ala Asp Thr Val Ser Ala Ser Thr Ser Gln Glu Ile Thr Met Val 
            20                  25                  30          


Asp Thr Glu Met Pro Phe Trp Pro Thr Asn Phe Gly Ile Ser Ser Val 
        35                  40                  45              


Asp Leu Ser Met Met Asp Asp His Ser His Ala Phe Asp Ile Lys Pro 
    50                  55                  60                  


Phe Thr Thr Val Asp Phe Ser Ser Ile Ser Ala Pro His Tyr Glu Asp 
65                  70                  75                  80  


Ile Pro Phe Pro Arg Ala Asp Pro Met Val Ala Asp Tyr Lys Tyr Asp 
                85                  90                  95      


Leu Lys Leu Gln Glu Tyr Gln Ser Ala Ile Lys Val Glu Pro Val Ser 
            100                 105                 110         


Pro Pro Tyr Tyr Ser Glu Lys Thr Gln Leu Tyr Ser Lys Pro His Glu 
        115                 120                 125             


Glu Pro Ser Asn Ser Leu Met Ala Ile Glu Cys Arg Val Cys Gly Asp 
    130                 135                 140                 


Lys Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys 
145                 150                 155                 160 


Gly Phe Phe Arg Arg Thr Ile Arg Leu Lys Leu Ile Tyr Asp Arg Cys 
                165                 170                 175     


Asp Leu Asn Cys Arg Ile His Lys Lys Ser Arg Asn Lys Cys Gln Tyr 
            180                 185                 190         


Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Ser His Asn Ala Ile 
        195                 200                 205             


Arg Phe Gly Arg Met Pro Gln Ala Glu Lys Glu Lys Leu Leu Ala Glu 
    210                 215                 220                 


Ile Ser Ser Asp Ile Asp Gln Leu Asn Pro Glu Ser Ala Asp Leu Arg 
225                 230                 235                 240 


Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys Ser Phe Pro Leu 
                245                 250                 255     


Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys Thr Thr Asp Lys 
            260                 265                 270         


Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Met Met Gly Glu Asp 
        275                 280                 285             


Lys Ile Lys Phe Lys His Ile Ser Pro Leu Gln Glu Pro Ser Lys Glu 
    290                 295                 300                 


Val Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg Ser Val Glu Ala 
305                 310                 315                 320 


Val Gln Glu Ile Thr Glu Tyr Ala Lys Asn Ile Pro Gly Phe Val Asn 
                325                 330                 335     


Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu 
            340                 345                 350         


Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys Asp Gly Val Leu 
        355                 360                 365             


Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe Leu Lys Ser Leu 
    370                 375                 380                 


Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe Glu Phe Ala Val 
385                 390                 395                 400 


Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Ile Phe Ile 
                405                 410                 415     


Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu Leu Asn Val Lys 
            420                 425                 430         


Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala Leu Glu Leu Gln 
        435                 440                 445             


Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe Ala Lys Leu Leu 
    450                 455                 460                 


Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu His Val Gln Leu 
465                 470                 475                 480 


Leu Gln Val Ile Lys Lys Thr Glu Thr Asp Met Ser Leu His Pro Leu 
                485                 490                 495     


Leu Gln Glu Ile Tyr Lys Asp Leu Tyr 
            500                 505 


<210>  79
<211>  504
<212>  PRT
<213>  Sus scrofa

<400>  79

Met Gly Glu Thr Leu Gly Asp Ser Leu Ile Asp Pro Glu Ser Asp Ala 
1               5                   10                  15      


Phe Asp Thr Leu Ser Ala Asn Ile Ser Gln Glu Val Thr Met Val Asp 
            20                  25                  30          


Thr Glu Met Pro Phe Trp Pro Thr Asn Phe Gly Ile Ser Ser Val Asp 
        35                  40                  45              


Leu Ser Val Met Asp Asp His Ser His Ser Phe Asp Ile Lys Pro Phe 
    50                  55                  60                  


Thr Thr Val Asp Phe Ser Ser Ile Ser Thr Pro His Tyr Glu Asp Ile 
65                  70                  75                  80  


Pro Phe Pro Arg Ala Asp Pro Met Val Ala Asp Tyr Lys Tyr Asp Leu 
                85                  90                  95      


Lys Leu Gln Asp Tyr Gln Ser Ala Ile Lys Val Glu Pro Val Ser Pro 
            100                 105                 110         


Pro Tyr Tyr Ser Glu Lys Thr Gln Leu Tyr Asn Lys Pro His Glu Glu 
        115                 120                 125             


Pro Ser Asn Ser Leu Met Ala Ile Glu Cys Arg Val Cys Gly Asp Lys 
    130                 135                 140                 


Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly 
145                 150                 155                 160 


Phe Phe Arg Arg Thr Ile Arg Leu Lys Leu Ile Tyr Asp Arg Cys Asp 
                165                 170                 175     


Leu Asn Cys Arg Ile His Lys Lys Ser Arg Asn Lys Cys Gln Tyr Cys 
            180                 185                 190         


Arg Phe Gln Lys Cys Leu Ala Val Gly Met Ser His Asn Ala Ile Arg 
        195                 200                 205             


Phe Gly Arg Met Pro Gln Ala Glu Lys Glu Lys Leu Leu Ala Glu Ile 
    210                 215                 220                 


Ser Ser Asp Ile Asp Gln Leu Asn Pro Glu Ser Ala Asp Leu Arg Ala 
225                 230                 235                 240 


Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys Ser Phe Pro Leu Thr 
                245                 250                 255     


Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys Thr Thr Asp Lys Ser 
            260                 265                 270         


Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Met Met Gly Glu Asp Lys 
        275                 280                 285             


Ile Lys Phe Lys His Ile Thr Pro Leu Gln Glu Gln Ser Lys Glu Val 
    290                 295                 300                 


Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg Ser Val Glu Ala Val 
305                 310                 315                 320 


Gln Glu Ile Thr Glu Tyr Ala Lys Asn Ile Pro Gly Phe Val Asn Leu 
                325                 330                 335     


Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu Ile 
            340                 345                 350         


Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys Asp Gly Val Leu Ile 
        355                 360                 365             


Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe Leu Lys Ser Leu Arg 
    370                 375                 380                 


Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe Glu Phe Ala Val Lys 
385                 390                 395                 400 


Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Ile Phe Ile Ala 
                405                 410                 415     


Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu Leu Asn Val Lys Pro 
            420                 425                 430         


Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala Leu Glu Leu Gln Leu 
        435                 440                 445             


Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe Ala Lys Leu Leu Gln 
    450                 455                 460                 


Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu His Val Gln Leu Leu 
465                 470                 475                 480 


Gln Val Ile Lys Lys Thr Glu Thr Asp Met Ser Leu His Pro Leu Leu 
                485                 490                 495     


Gln Glu Ile Tyr Lys Asp Leu Tyr 
            500                 


<210>  80
<211>  359
<212>  PRT
<213>  Mus musculus

<400>  80

Met Glu Ser Ala Asp Phe Tyr Glu Val Glu Pro Arg Pro Pro Met Ser 
1               5                   10                  15      


Ser His Leu Gln Ser Pro Pro His Ala Pro Ser Asn Ala Ala Phe Gly 
            20                  25                  30          


Phe Pro Arg Gly Ala Gly Pro Ala Pro Pro Pro Ala Pro Pro Ala Ala 
        35                  40                  45              


Pro Glu Pro Leu Gly Gly Ile Cys Glu His Glu Thr Ser Ile Asp Ile 
    50                  55                  60                  


Ser Ala Tyr Ile Asp Pro Ala Ala Phe Asn Asp Glu Phe Leu Ala Asp 
65                  70                  75                  80  


Leu Phe Gln His Ser Arg Gln Gln Glu Lys Ala Lys Ala Ala Ala Gly 
                85                  90                  95      


Pro Ala Gly Gly Gly Gly Asp Phe Asp Tyr Pro Gly Ala Pro Ala Gly 
            100                 105                 110         


Pro Gly Gly Ala Val Met Ser Ala Gly Ala His Gly Pro Pro Pro Gly 
        115                 120                 125             


Tyr Gly Cys Ala Ala Ala Gly Tyr Leu Asp Gly Arg Leu Glu Pro Leu 
    130                 135                 140                 


Tyr Glu Arg Val Gly Ala Pro Ala Leu Arg Pro Leu Val Ile Lys Gln 
145                 150                 155                 160 


Glu Pro Arg Glu Glu Asp Glu Ala Lys Gln Leu Ala Leu Ala Gly Leu 
                165                 170                 175     


Phe Pro Tyr Gln Pro Pro Pro Pro Pro Pro Pro Pro His Pro His Ala 
            180                 185                 190         


Ser Pro Ala His Leu Ala Ala Pro His Leu Gln Phe Gln Ile Ala His 
        195                 200                 205             


Cys Gly Gln Thr Thr Met His Leu Gln Pro Gly His Pro Thr Pro Pro 
    210                 215                 220                 


Pro Thr Pro Val Pro Ser Pro His Ala Ala Pro Ala Leu Gly Ala Ala 
225                 230                 235                 240 


Gly Leu Pro Gly Pro Gly Ser Ala Leu Lys Gly Leu Ala Gly Ala His 
                245                 250                 255     


Pro Asp Leu Arg Thr Gly Gly Gly Gly Gly Gly Ser Gly Ala Gly Ala 
            260                 265                 270         


Gly Lys Ala Lys Lys Ser Val Asp Lys Asn Ser Asn Glu Tyr Arg Val 
        275                 280                 285             


Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser Arg Asp Lys Ala 
    290                 295                 300                 


Lys Gln Arg Asn Val Glu Thr Gln Gln Lys Val Leu Glu Leu Thr Ser 
305                 310                 315                 320 


Asp Asn Asp Arg Leu Arg Lys Arg Val Glu Gln Leu Ser Arg Glu Leu 
                325                 330                 335     


Asp Thr Leu Arg Gly Ile Phe Arg Gln Leu Pro Glu Ser Ser Leu Val 
            340                 345                 350         


Lys Ala Met Gly Asn Cys Ala 
        355                 


<210>  81
<211>  324
<212>  PRT
<213>  Gallus gallus

<400>  81

Met Glu Gln Ala Asn Phe Tyr Glu Val Asp Ser Arg Pro Pro Met Ser 
1               5                   10                  15      


Ser Gly Gln His His Gln Leu Gln Thr Pro Leu Pro Gly Ser Ala Tyr 
            20                  25                  30          


Gly Tyr Arg Glu Ala Pro Ser Ala Ala Ala Pro Ala Ala Gly Gly Ala 
        35                  40                  45              


Glu Leu Gly Asp Ile Cys Glu Asn Glu His Ser Ile Asp Ile Ser Ala 
    50                  55                  60                  


Tyr Ile Asp Pro Ala Ala Phe Asn Asp Glu Phe Leu Ala Asp Leu Phe 
65                  70                  75                  80  


Gln His Ser Lys Gln Gln Glu Lys His Lys Ala Val Leu Ala Gly Asp 
                85                  90                  95      


Phe Asp Phe His Gly Met His Gly Ala Gly Ala Ala Ala Ser Ala Pro 
            100                 105                 110         


Gly His His Pro Gln His Gln Gln Gln Pro Leu Phe Gly Cys Ala Ala 
        115                 120                 125             


Gly Tyr Met Asp Gly Lys Leu Asp Pro Leu Tyr Glu Arg Ile Ala Ala 
    130                 135                 140                 


Pro Gly Leu Arg Pro Leu Val Ile Lys Gln Glu Pro Arg Glu Glu Glu 
145                 150                 155                 160 


Glu Val Lys Ala Ala Ala Leu Ala Ala Leu Tyr Pro His Pro Gln Gln 
                165                 170                 175     


His Pro Ser His Leu Gln Tyr Gln Ile Ala His Cys Ala Gln Thr Thr 
            180                 185                 190         


Val His Leu Gln Pro Gly His Pro Thr Pro Pro Pro Thr Pro Val Pro 
        195                 200                 205             


Ser Pro His His Pro His His Pro His Pro Pro Gly Ala Leu Pro Ala 
    210                 215                 220                 


Ala Pro Gly Ala Leu Lys Met Met Pro Ala Asp His Arg Gly Lys Ser 
225                 230                 235                 240 


Lys Lys Thr Val Asp Lys Asn Ser Asn Glu Tyr Arg Val Arg Arg Glu 
                245                 250                 255     


Arg Asn Asn Ile Ala Val Arg Lys Ser Arg Asp Lys Ala Lys Gln Arg 
            260                 265                 270         


Asn Val Glu Thr Gln Gln Lys Val Leu Glu Leu Thr Thr Asp Asn Glu 
        275                 280                 285             


Arg Leu Arg Lys Arg Val Glu Gln Leu Ser Arg Glu Leu Glu Thr Leu 
    290                 295                 300                 


Arg Gly Ile Phe Arg Gln Leu Pro Glu Ser Ser Leu Val Lys Ala Met 
305                 310                 315                 320 


Gly Ser Cys Ala 
                


<210>  82
<211>  353
<212>  PRT
<213>  Capra hircus

<400>  82

Met Glu Ser Ala Asp Phe Tyr Glu Ala Glu Pro Arg Pro Pro Met Ser 
1               5                   10                  15      


Ser His Leu Gln Ser Pro Ala His Ala Pro Ser Ser Ala Ala Phe Gly 
            20                  25                  30          


Phe Pro Arg Gly Ala Gly Pro Ser Gln Pro Pro Ala Pro Pro Ala Ala 
        35                  40                  45              


Pro Glu Pro Leu Gly Gly Ile Cys Glu His Glu Thr Ser Ile Asp Ile 
    50                  55                  60                  


Ser Ala Tyr Ile Asp Pro Ala Ala Phe Asn Asp Glu Phe Leu Ala Asp 
65                  70                  75                  80  


Leu Phe Gln His Ser Arg Gln Gln Glu Lys Ala Lys Ala Ala Ala Ala 
                85                  90                  95      


Pro Ala Gly Gly Gly Asn Asp Phe Asp Tyr Pro Gly Ala Pro Val Gly 
            100                 105                 110         


Pro Gly Gly Ala Val Met Pro Gly Gly Thr His Gly Pro Pro Pro Gly 
        115                 120                 125             


Tyr Gly Cys Ala Ala Ala Gly Tyr Leu Asp Ser Arg Leu Glu Pro Leu 
    130                 135                 140                 


Tyr Glu Arg Val Gly Ala Pro Ala Leu Arg Pro Leu Val Ile Lys Gln 
145                 150                 155                 160 


Glu Pro Arg Glu Glu Asp Glu Ala Lys Gln Leu Ala Leu Ala Gly Leu 
                165                 170                 175     


Phe Pro Tyr Gln Pro Pro Pro Pro Pro Pro Pro Pro His Ser His Pro 
            180                 185                 190         


Pro Pro Ala His Leu Ala Ala Pro His Leu Gln Phe Gln Ile Ala His 
        195                 200                 205             


Cys Gly Gln Thr Thr Met His Leu Gln Pro Gly His Pro Thr Pro Pro 
    210                 215                 220                 


Pro Thr Pro Val Pro Ser Pro His Pro Ala Pro Ala Leu Gly Ala Ala 
225                 230                 235                 240 


Gly Leu Pro Gly Pro Gly Gly Ala Leu Lys Gly Leu Ala Ala Ala His 
                245                 250                 255     


Pro Asp Leu Arg Ala Gly Gly Gly Gly Gly Gly Lys Ala Lys Lys Ser 
            260                 265                 270         


Val Asp Lys Asn Ser Asn Glu Tyr Arg Val Arg Arg Glu Arg Asn Asn 
        275                 280                 285             


Ile Ala Val Arg Lys Ser Arg Asp Lys Ala Lys Gln Arg Asn Val Glu 
    290                 295                 300                 


Thr Gln Gln Lys Val Leu Glu Leu Thr Ser Asp Asn Asp Arg Leu Arg 
305                 310                 315                 320 


Lys Arg Val Glu Gln Leu Ser Arg Glu Leu Asp Thr Leu Arg Gly Ile 
                325                 330                 335     


Phe Arg Gln Leu Pro Glu Ser Ser Leu Val Lys Ala Met Gly Asn Cys 
            340                 345                 350         


Ala 
    


<210>  83
<211>  1134
<212>  PRT
<213>  Mus musculus

<400>  83

Met Asp Glu Leu Ala Phe Gly Glu Ala Ala Leu Glu Gln Thr Leu Ala 
1               5                   10                  15      


Glu Met Cys Glu Leu Asp Thr Ala Val Leu Asn Asp Ile Glu Asp Met 
            20                  25                  30          


Leu Gln Leu Ile Asn Asn Gln Asp Ser Asp Phe Pro Gly Leu Phe Asp 
        35                  40                  45              


Ala Pro Tyr Ala Gly Gly Glu Thr Gly Asp Thr Gly Pro Ser Ser Pro 
    50                  55                  60                  


Gly Ala Asn Ser Pro Glu Ser Phe Ser Ser Ala Ser Leu Ala Ser Ser 
65                  70                  75                  80  


Leu Glu Ala Phe Leu Gly Gly Pro Lys Val Thr Pro Ala Pro Leu Ser 
                85                  90                  95      


Pro Pro Pro Ser Ala Pro Ala Ala Leu Lys Met Tyr Pro Ser Val Ser 
            100                 105                 110         


Pro Phe Ser Pro Gly Pro Gly Ile Lys Glu Glu Pro Val Pro Leu Thr 
        115                 120                 125             


Ile Leu Gln Pro Ala Ala Pro Gln Pro Ser Pro Gly Thr Leu Leu Pro 
    130                 135                 140                 


Pro Ser Phe Pro Ala Pro Pro Val Gln Leu Ser Pro Ala Pro Val Leu 
145                 150                 155                 160 


Gly Tyr Ser Ser Leu Pro Ser Gly Phe Ser Gly Thr Leu Pro Gly Asn 
                165                 170                 175     


Thr Gln Gln Pro Pro Ser Ser Leu Pro Leu Ala Pro Ala Pro Gly Val 
            180                 185                 190         


Leu Pro Thr Pro Ala Leu His Thr Gln Val Gln Ser Leu Ala Ser Gln 
        195                 200                 205             


Gln Pro Leu Pro Ala Ser Ala Ala Pro Arg Thr Asn Thr Val Thr Ser 
    210                 215                 220                 


Gln Val Gln Gln Val Pro Val Val Leu Gln Pro His Phe Ile Lys Ala 
225                 230                 235                 240 


Asp Ser Leu Leu Leu Thr Ala Val Lys Thr Asp Ala Gly Ala Thr Val 
                245                 250                 255     


Lys Thr Ala Gly Ile Ser Thr Leu Ala Pro Gly Thr Ala Val Gln Ala 
            260                 265                 270         


Gly Pro Leu Gln Thr Leu Val Ser Gly Gly Thr Ile Leu Ala Thr Val 
        275                 280                 285             


Pro Leu Val Val Asp Thr Asp Lys Leu Pro Ile His Arg Leu Ala Ala 
    290                 295                 300                 


Gly Ser Lys Ala Leu Gly Ser Ala Gln Ser Arg Gly Glu Lys Arg Thr 
305                 310                 315                 320 


Ala His Asn Ala Ile Glu Lys Arg Tyr Arg Ser Ser Ile Asn Asp Lys 
                325                 330                 335     


Ile Val Glu Leu Lys Asp Leu Val Val Gly Thr Glu Ala Lys Leu Asn 
            340                 345                 350         


Lys Ser Ala Val Leu Arg Lys Ala Ile Asp Tyr Ile Arg Phe Leu Gln 
        355                 360                 365             


His Ser Asn Gln Lys Leu Lys Gln Glu Asn Leu Thr Leu Arg Ser Ala 
    370                 375                 380                 


His Lys Ser Lys Ser Leu Lys Asp Leu Val Ser Ala Cys Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Thr Asp Val Ser Met Glu Gly Met Lys Pro Glu Val Val Glu 
                405                 410                 415     


Thr Leu Thr Pro Pro Pro Ser Asp Ala Gly Ser Pro Ser Gln Ser Ser 
            420                 425                 430         


Pro Leu Ser Phe Gly Ser Arg Ala Ser Ser Ser Gly Gly Ser Asp Ser 
        435                 440                 445             


Glu Pro Asp Ser Pro Ala Phe Glu Asp Ser Gln Val Lys Ala Gln Arg 
    450                 455                 460                 


Leu Pro Ser His Ser Arg Gly Met Leu Asp Arg Ser Arg Leu Ala Leu 
465                 470                 475                 480 


Cys Val Leu Ala Phe Leu Cys Leu Thr Cys Asn Pro Leu Ala Ser Leu 
                485                 490                 495     


Phe Gly Trp Gly Ile Leu Thr Pro Ser Asp Ala Thr Gly Thr His Arg 
            500                 505                 510         


Ser Ser Gly Arg Ser Met Leu Glu Ala Glu Ser Arg Asp Gly Ser Asn 
        515                 520                 525             


Trp Thr Gln Trp Leu Leu Pro Pro Leu Val Trp Leu Ala Asn Gly Leu 
    530                 535                 540                 


Leu Val Leu Ala Cys Leu Ala Leu Leu Phe Val Tyr Gly Glu Pro Val 
545                 550                 555                 560 


Thr Arg Pro His Ser Gly Pro Ala Val His Phe Trp Arg His Arg Lys 
                565                 570                 575     


Gln Ala Asp Leu Asp Leu Ala Arg Gly Asp Phe Pro Gln Ala Ala Gln 
            580                 585                 590         


Gln Leu Trp Leu Ala Leu Gln Ala Leu Gly Arg Pro Leu Pro Thr Ser 
        595                 600                 605             


Asn Leu Asp Leu Ala Cys Ser Leu Leu Trp Asn Leu Ile Arg His Leu 
    610                 615                 620                 


Leu Gln Arg Leu Trp Val Gly Arg Trp Leu Ala Gly Gln Ala Gly Gly 
625                 630                 635                 640 


Leu Leu Arg Asp Arg Gly Leu Arg Lys Asp Ala Arg Ala Ser Ala Arg 
                645                 650                 655     


Asp Ala Ala Val Val Tyr His Lys Leu His Gln Leu His Ala Met Gly 
            660                 665                 670         


Lys Tyr Thr Gly Gly His Leu Ala Ala Ser Asn Leu Ala Leu Ser Ala 
        675                 680                 685             


Leu Asn Leu Ala Glu Cys Ala Gly Asp Ala Ile Ser Met Ala Thr Leu 
    690                 695                 700                 


Ala Glu Ile Tyr Val Ala Ala Ala Leu Arg Val Lys Thr Ser Leu Pro 
705                 710                 715                 720 


Arg Ala Leu His Phe Leu Thr Arg Phe Phe Leu Ser Ser Ala Arg Gln 
                725                 730                 735     


Ala Cys Leu Ala Gln Ser Gly Ser Val Pro Leu Ala Met Gln Trp Leu 
            740                 745                 750         


Cys His Pro Val Gly His Arg Phe Phe Val Asp Gly Asp Trp Ala Val 
        755                 760                 765             


His Gly Ala Pro Pro Glu Ser Leu Tyr Ser Val Ala Gly Asn Pro Val 
    770                 775                 780                 


Asp Pro Leu Ala Gln Val Thr Arg Leu Phe Arg Glu His Leu Leu Glu 
785                 790                 795                 800 


Arg Ala Leu Asn Cys Ile Ala Gln Pro Ser Pro Gly Ala Ala Asp Gly 
                805                 810                 815     


Asp Arg Glu Phe Ser Asp Ala Leu Gly Tyr Leu Gln Leu Leu Asn Ser 
            820                 825                 830         


Cys Ser Asp Ala Ala Gly Ala Pro Ala Cys Ser Phe Ser Val Ser Ser 
        835                 840                 845             


Ser Met Ala Ala Thr Thr Gly Pro Asp Pro Val Ala Lys Trp Trp Ala 
    850                 855                 860                 


Ser Leu Thr Ala Val Val Ile His Trp Leu Arg Arg Asp Glu Glu Ala 
865                 870                 875                 880 


Ala Glu Arg Leu Tyr Pro Leu Val Glu His Ile Pro Gln Val Leu Gln 
                885                 890                 895     


Asp Thr Glu Arg Pro Leu Pro Arg Ala Ala Leu Tyr Ser Phe Lys Ala 
            900                 905                 910         


Ala Arg Ala Leu Leu Asp His Arg Lys Val Glu Ser Ser Pro Ala Ser 
        915                 920                 925             


Leu Ala Ile Cys Glu Lys Ala Ser Gly Tyr Leu Arg Asp Ser Leu Ala 
    930                 935                 940                 


Ser Thr Pro Thr Gly Ser Ser Ile Asp Lys Ala Met Gln Leu Leu Leu 
945                 950                 955                 960 


Cys Asp Leu Leu Leu Val Ala Arg Thr Ser Leu Trp Gln Arg Gln Gln 
                965                 970                 975     


Ser Pro Ala Ser Val Gln Val Ala His Gly Thr Ser Asn Gly Pro Gln 
            980                 985                 990         


Ala Ser Ala Leu Glu Leu Arg Gly  Phe Gln His Asp Leu  Ser Ser Leu 
        995                 1000                 1005             


Arg Arg  Leu Ala Gln Ser Phe  Arg Pro Ala Met Arg  Arg Val Phe 
    1010                 1015                 1020             


Leu His  Glu Ala Thr Ala Arg  Leu Met Ala Gly Ala  Ser Pro Ala 
    1025                 1030                 1035             


Arg Thr  His Gln Leu Leu Asp  Arg Ser Leu Arg Arg  Arg Ala Gly 
    1040                 1045                 1050             


Ser Ser  Gly Lys Gly Gly Thr  Thr Ala Glu Leu Glu  Pro Arg Pro 
    1055                 1060                 1065             


Thr Trp  Arg Glu His Thr Glu  Ala Leu Leu Leu Ala  Ser Cys Tyr 
    1070                 1075                 1080             


Leu Pro  Pro Ala Phe Leu Ser  Ala Pro Gly Gln Arg  Met Ser Met 
    1085                 1090                 1095             


Leu Ala  Glu Ala Ala Arg Thr  Val Glu Lys Leu Gly  Asp His Arg 
    1100                 1105                 1110             


Leu Leu  Leu Asp Cys Gln Gln  Met Leu Leu Arg Leu  Gly Gly Gly 
    1115                 1120                 1125             


Thr Thr  Val Thr Ser Ser 
    1130                 


<210>  84
<211>  232
<212>  PRT
<213>  Gallus gallus


<220>
<221>  misc_feature
<222>  (226)..(226)
<223>  Xaa can be any naturally occurring amino acid

<400>  84

Lys Thr Asp Ala Gly Gly Ala Lys Thr Ser Ser Ile Thr Ser Leu Ala 
1               5                   10                  15      


Thr Ser Ser Thr Ala Ala Pro Leu Gln Val Pro Ala Leu Val Ser Gly 
            20                  25                  30          


Gly Thr Ile Leu Ala Thr Val Pro Leu Val Val Asp Ala Glu Lys Leu 
        35                  40                  45              


Pro Ile Asn Arg Leu Ala Pro Ser Gly Lys Ala Ala Leu Leu Gln Ser 
    50                  55                  60                  


Lys Gly Glu Lys Arg Thr Ala His Asn Ala Ile Glu Lys Arg Tyr Arg 
65                  70                  75                  80  


Ser Ser Ile Asn Asp Lys Ile Val Glu Leu Lys Asp Leu Val Val Gly 
                85                  90                  95      


Thr Glu Ala Lys Leu Asn Lys Ser Ala Ile Leu Arg Lys Ala Ile Glu 
            100                 105                 110         


Tyr Ile Arg Phe Leu Gln Gln Ser Asn Gln Lys Leu Lys Gln Glu Asn 
        115                 120                 125             


Leu Ser Leu Lys Met Ala Val Gln Lys Ser Lys Ser Leu Lys Asp Leu 
    130                 135                 140                 


Val Ala Ser Cys Gly Ala Gly Pro Lys Ala Glu Ala Ser Met Glu Val 
145                 150                 155                 160 


Ala Lys Ala Glu Val Met Glu Met Pro Thr Pro Pro Pro Ser Asp Val 
                165                 170                 175     


Gly Ser Pro Ser Arg Gly Ser Pro Leu Ser Leu Ser Gly Gly Ser Ser 
            180                 185                 190         


Asn Ser Ser Ser Asp Ser Glu Pro Asp Ser Pro Leu Cys Asn His Gly 
        195                 200                 205             


Lys Val Lys Gln Glu Asn Pro Pro Pro Ser Pro Gly Ser Gln Gly Met 
    210                 215                 220                 


Leu Xaa Arg Ser Arg Met Ala Leu 
225                 230         


<210>  85
<211>  132
<212>  PRT
<213>  Bos taurus

<400>  85

Met Cys Asp Ala Phe Val Gly Thr Trp Lys Leu Val Ser Ser Glu Asn 
1               5                   10                  15      


Phe Asp Asp Tyr Met Lys Glu Val Gly Val Gly Phe Ala Thr Arg Lys 
            20                  25                  30          


Val Ala Gly Met Ala Lys Pro Thr Leu Ile Ile Ser Leu Asn Gly Gly 
        35                  40                  45              


Val Val Thr Ile Lys Ser Glu Ser Thr Phe Lys Asn Thr Glu Ile Ser 
    50                  55                  60                  


Phe Lys Leu Gly Gln Glu Phe Asp Glu Ile Thr Pro Asp Asp Arg Lys 
65                  70                  75                  80  


Val Lys Ser Ile Val Asn Leu Asp Glu Gly Ala Leu Val Gln Val Gln 
                85                  90                  95      


Asn Trp Asp Gly Lys Ser Thr Thr Ile Lys Arg Lys Leu Met Asp Asp 
            100                 105                 110         


Lys Met Val Leu Glu Cys Val Met Asn Gly Val Thr Ala Thr Arg Val 
        115                 120                 125             


Tyr Glu Arg Ala 
    130         


<210>  86
<211>  1292
<212>  PRT
<213>  Bos taurus

<400>  86

Met Ser Arg Arg Lys Gln Ala Lys Pro Arg Ser Val Lys Val Glu Glu 
1               5                   10                  15      


Gly Glu Ala Ser Asp Phe Ser Leu Ala Trp Asp Ser Ser Val Thr Ala 
            20                  25                  30          


Ser Gly Gly Leu Glu Gly Glu Pro Glu Cys Asp Arg Lys Thr Ser Arg 
        35                  40                  45              


Val Leu Glu Asp Arg Asn Ser Val Thr Ser Gln Glu Glu Arg Asn Glu 
    50                  55                  60                  


Asp Asp Glu Asp Val Glu Asp Glu Ser Ile Tyr Thr Cys Asp His Cys 
65                  70                  75                  80  


Gln Gln Asp Phe Glu Ser Leu Ala Glu Leu Thr Asp His Arg Ala His 
                85                  90                  95      


Arg Cys Pro Gly Asp Gly Asp Asp Asp Pro Gln Leu Ser Trp Val Ala 
            100                 105                 110         


Ser Ser Pro Ser Ser Lys Asp Val Ala Ser Pro Thr Gln Met Ile Gly 
        115                 120                 125             


Asp Gly Cys Asp Leu Gly Leu Gly Glu Glu Glu Gly Gly Thr Gly Leu 
    130                 135                 140                 


Pro Tyr Pro Cys Gln Phe Cys Asp Lys Ser Phe Ile Arg Leu Ser Tyr 
145                 150                 155                 160 


Leu Lys Arg His Glu Gln Ile His Ser Asp Lys Leu Pro Phe Lys Cys 
                165                 170                 175     


Thr Tyr Cys Ser Arg Leu Phe Lys His Lys Arg Ser Arg Asp Arg His 
            180                 185                 190         


Ile Lys Leu His Thr Gly Asp Lys Lys Tyr His Cys His Glu Cys Glu 
        195                 200                 205             


Ala Ala Phe Ser Arg Ser Asp His Leu Lys Ile His Leu Lys Thr His 
    210                 215                 220                 


Ser Ser Ser Lys Pro Phe Lys Cys Thr Val Cys Lys Arg Gly Phe Ser 
225                 230                 235                 240 


Ser Thr Ser Ser Leu Gln Ser His Met Gln Ala His Lys Lys Asn Lys 
                245                 250                 255     


Glu His Leu Ala Lys Ser Glu Lys Glu Ala Lys Lys Asp Asp Phe Met 
            260                 265                 270         


Cys Asp Tyr Cys Glu Asp Thr Phe Ser Gln Thr Glu Glu Leu Glu Lys 
        275                 280                 285             


His Val Leu Thr Arg His Pro Gln Leu Ser Glu Lys Ala Asp Leu Gln 
    290                 295                 300                 


Cys Ile His Cys Pro Glu Val Phe Val Asp Glu Asn Ala Leu Leu Ala 
305                 310                 315                 320 


His Ile His Gln Ala His Ala Asn Gln Lys His Lys Cys Pro Met Cys 
                325                 330                 335     


Pro Glu Gln Phe Ser Ser Val Glu Gly Val Tyr Cys His Leu Asp Ser 
            340                 345                 350         


His Arg Gln Pro Asp Ser Ser Asn His Ser Val Ser Pro Asp Pro Val 
        355                 360                 365             


Leu Gly Ser Val Ala Ser Met Ser Ser Ala Thr Pro Asp Ser Ser Ala 
    370                 375                 380                 


Ser Val Glu Arg Gly Ser Thr Pro Asp Ser Thr Leu Lys Pro Leu Arg 
385                 390                 395                 400 


Gly Gln Lys Lys Met Arg Asp Asp Gly Gln Gly Trp Ser Lys Val Val 
                405                 410                 415     


Tyr Ser Cys Pro Tyr Cys Ser Lys Arg Asp Phe Asn Ser Leu Ala Val 
            420                 425                 430         


Leu Glu Ile His Leu Lys Thr Ile His Ala Asp Lys Pro Gln Gln Ser 
        435                 440                 445             


His Thr Cys Gln Ile Cys Leu Asp Ser Met Pro Thr Leu Tyr Asn Leu 
    450                 455                 460                 


Asn Glu His Val Arg Lys Leu His Lys Asn His Ala Tyr Pro Val Met 
465                 470                 475                 480 


Gln Phe Gly Ser Ile Ser Ala Phe His Cys Asn Tyr Cys Pro Glu Met 
                485                 490                 495     


Phe Ala Asp Ile Asn Ser Leu Gln Glu His Ile Arg Val Ser His Cys 
            500                 505                 510         


Gly Pro Asn Ala Asn Pro Pro Asp Gly Asn Asn Ala Phe Phe Cys Asn 
        515                 520                 525             


Gln Cys Ser Met Gly Phe Leu Thr Glu Ser Ser Leu Thr Glu His Ile 
    530                 535                 540                 


Gln Gln Ala His Cys Ser Val Gly Ser Ala Lys Leu Glu Ser Pro Val 
545                 550                 555                 560 


Val Gln Pro Thr Gln Ser Phe Met Glu Val Tyr Ser Cys Pro Tyr Cys 
                565                 570                 575     


Thr Asn Ser Pro Ile Phe Gly Ser Ile Leu Lys Leu Thr Lys His Ile 
            580                 585                 590         


Lys Glu Asn His Lys Asn Ile Pro Leu Ala His Ser Lys Lys Ser Lys 
        595                 600                 605             


Ala Glu Gln Ser Pro Val Ser Ser Asp Val Glu Val Ser Ser Pro Lys 
    610                 615                 620                 


Arg Gln Arg Leu Ser Ala Ser Ala Asn Ser Ile Ser Asn Gly Glu Tyr 
625                 630                 635                 640 


Pro Cys Asn Gln Cys Asp Leu Lys Phe Ser Asn Phe Glu Ser Phe Gln 
                645                 650                 655     


Thr His Leu Lys Leu His Leu Glu Leu Leu Leu Arg Lys Gln Ala Cys 
            660                 665                 670         


Pro Gln Cys Lys Glu Asp Phe Asp Ser Gln Glu Ser Leu Leu Gln His 
        675                 680                 685             


Leu Thr Val His Tyr Met Thr Thr Ser Thr His Tyr Val Cys Glu Ser 
    690                 695                 700                 


Cys Asp Lys Gln Phe Ser Ser Val Asp Asp Leu Gln Lys His Leu Leu 
705                 710                 715                 720 


Asp Met His Thr Phe Val Leu Tyr His Cys Thr Leu Cys Gln Glu Val 
                725                 730                 735     


Phe Asp Ser Lys Val Ser Ile Gln Val His Leu Ala Val Lys His Ser 
            740                 745                 750         


Asn Glu Lys Lys Met Phe Arg Cys Thr Ala Cys Asn Trp Asp Phe Arg 
        755                 760                 765             


Lys Glu Ala Asp Leu Gln Val His Val Lys His Ser His Leu Gly Asn 
    770                 775                 780                 


Pro Ala Arg Ala His Lys Cys Ile Phe Cys Gly Glu Thr Phe Ser Thr 
785                 790                 795                 800 


Glu Val Glu Leu Gln Cys His Ile Thr Thr His Ser Lys Lys Tyr Asn 
                805                 810                 815     


Cys Lys Phe Cys Ser Lys Ala Phe His Ala Ile Ile Leu Leu Glu Lys 
            820                 825                 830         


His Leu Arg Glu Lys His Cys Val Phe Asp Ala Ala Ala Glu Asn Gly 
        835                 840                 845             


Thr Ala Asn Gly Val Pro Pro Ala Ala Ala Lys Lys Ala Glu Pro Ala 
    850                 855                 860                 


Asp Leu Pro Gly Val Leu Leu Lys Asn Pro Glu Ala Pro Asn Ser His 
865                 870                 875                 880 


Glu Ala Ser Glu Asp Asp Val Asp Ala Ser Glu Pro Met Tyr Gly Cys 
                885                 890                 895     


Asp Ile Cys Gly Ala Ala Tyr Thr Met Glu Val Leu Leu Gln Asn His 
            900                 905                 910         


Arg Leu Arg Asp His Asn Ile Arg Pro Gly Glu Asp Asp Gly Ser Arg 
        915                 920                 925             


Lys Lys Ala Glu Phe Ile Lys Gly Ser His Lys Cys Asn Val Cys Ser 
    930                 935                 940                 


Arg Thr Phe Phe Ser Glu Asn Gly Leu Arg Glu His Leu Gln Thr His 
945                 950                 955                 960 


Arg Gly Pro Ala Lys His Tyr Met Cys Pro Ile Cys Gly Glu Arg Phe 
                965                 970                 975     


Pro Ser Leu Leu Thr Leu Thr Glu His Lys Val Thr His Ser Lys Ser 
            980                 985                 990         


Leu Asp Thr Gly Thr Cys Arg Ile  Cys Lys Met Pro Leu  Gln Ser Glu 
        995                 1000                 1005             


Glu Glu  Phe Ile Glu His Cys  Gln Met His Pro Asp  Leu Arg Asn 
    1010                 1015                 1020             


Ser Leu  Thr Gly Phe Arg Cys  Val Val Cys Met Gln  Thr Val Thr 
    1025                 1030                 1035             


Ser Thr  Leu Glu Leu Lys Ile  His Gly Thr Phe His  Met Gln Lys 
    1040                 1045                 1050             


Leu Ala  Gly Ser Ser Ala Ala  Ser Ser Pro Asn Gly  Gln Gly Leu 
    1055                 1060                 1065             


Gln Lys  Leu Tyr Lys Cys Ala  Leu Cys Leu Lys Glu  Phe Arg Ser 
    1070                 1075                 1080             


Lys Gln  Asp Leu Val Lys Leu  Asp Val Asn Gly Leu  Pro Tyr Gly 
    1085                 1090                 1095             


Leu Cys  Ala Gly Cys Met Ala  Arg Ser Ala Asn Gly  Gln Val Gly 
    1100                 1105                 1110             


Gly Leu  Ala Pro Pro Glu Pro  Ala Asp Arg Pro Cys  Ala Gly Leu 
    1115                 1120                 1125             


Arg Cys  Pro Glu Cys Ser Val  Lys Phe Glu Ser Ala  Glu Asp Leu 
    1130                 1135                 1140             


Glu Ser  His Met Gln Val Asp  His Arg Asp Leu Thr  Pro Glu Thr 
    1145                 1150                 1155             


Ser Gly  Pro Arg Lys Gly Ala  Gln Thr Ser Pro Val  Pro Arg Lys 
    1160                 1165                 1170             


Lys Thr  Tyr Gln Cys Ile Lys  Cys Gln Met Thr Phe  Glu Asn Glu 
    1175                 1180                 1185             


Arg Glu  Ile Gln Ile His Val  Ala Asn His Met Ile  Glu Glu Gly 
    1190                 1195                 1200             


Ile Asn  His Glu Cys Lys Leu  Cys Asn Gln Met Phe  Asp Ser Pro 
    1205                 1210                 1215             


Ala Lys  Leu Leu Cys His Leu  Ile Glu His Ser Phe  Glu Gly Met 
    1220                 1225                 1230             


Gly Gly  Thr Phe Lys Cys Pro  Val Cys Phe Thr Val  Phe Val Gln 
    1235                 1240                 1245             


Ala Asn  Lys Leu Gln Gln His  Ile Phe Ala Val His  Gly Gln Glu 
    1250                 1255                 1260             


Asp Lys  Ile Tyr Asp Cys Ser  Gln Cys Pro Gln Lys  Phe Phe Phe 
    1265                 1270                 1275             


Gln Thr  Glu Leu Gln Asn His  Thr Met Ser Gln His  Ala Gln 
    1280                 1285                 1290         


<210>  87
<211>  673
<212>  PRT
<213>  Bos taurus

<400>  87

Met Asp Leu Thr Lys Met Gly Met Ile Gln Leu Gln Asn Pro Ser His 
1               5                   10                  15      


Pro Thr Gly Leu Leu Cys Lys Ala Asn Gln Met Arg Leu Ala Gly Thr 
            20                  25                  30          


Leu Cys Asp Val Val Ile Met Val Asp Ser Gln Glu Phe His Ala His 
        35                  40                  45              


Arg Thr Val Leu Ala Cys Thr Ser Lys Met Phe Glu Ile Leu Phe His 
    50                  55                  60                  


Arg Asn Ser Gln His Tyr Thr Leu Asp Phe Leu Ser Pro Lys Thr Phe 
65                  70                  75                  80  


Gln Gln Ile Leu Glu Tyr Ala Tyr Thr Ala Thr Leu Gln Ala Lys Ala 
                85                  90                  95      


Glu Asp Leu Asp Asp Leu Leu Tyr Ala Ala Glu Ile Leu Glu Ile Glu 
            100                 105                 110         


Tyr Leu Glu Glu Gln Cys Leu Lys Ile Leu Glu Thr Ile Gln Ala Ser 
        115                 120                 125             


Asp Asp Asn Asp Thr Glu Ala Thr Met Ala Glu Gly Gly Ala Glu Glu 
    130                 135                 140                 


Glu Glu Asp Arg Lys Ala Arg Tyr Leu Lys Asn Ile Phe Ile Ser Lys 
145                 150                 155                 160 


His Ser Ser Glu Glu Ser Gly Tyr Ala Ser Val Ala Ala Gln Ser Leu 
                165                 170                 175     


Pro Gly Pro Met Val Asp Gln Ser Pro Ser Val Ser Thr Ser Phe Gly 
            180                 185                 190         


Leu Ser Ala Met Ser Pro Thr Lys Ala Ala Val Asp Ser Leu Met Thr 
        195                 200                 205             


Ile Gly Gln Ser Leu Leu Gln Gly Ala Leu Gln Pro Pro Ala Gly Pro 
    210                 215                 220                 


Glu Glu Pro Thr Leu Ala Gly Gly Gly Arg His Pro Ala Val Ala Glu 
225                 230                 235                 240 


Val Lys Pro Glu Met Met Gln Val Asp Glu Val Pro Gly Gln Glu Ser 
                245                 250                 255     


Pro Gly Thr Val Glu Ser Ser Ile Ser Ala Gly Met Gly Asp Lys Val 
            260                 265                 270         


Glu Glu Arg Gly Lys Glu Gly Pro Gly Thr Pro Thr Arg Ser Ser Val 
        275                 280                 285             


Ile Thr Ser Ala Arg Glu Leu His Tyr Gly Arg Glu Glu Ser Thr Glu 
    290                 295                 300                 


Gln Leu Pro Pro Pro Val Glu Ala Gly Gln Gly Pro Pro Gly Arg Leu 
305                 310                 315                 320 


Glu Pro Pro Ala His Pro Ala Glu Lys His Leu Gly Leu Tyr Ser Val 
                325                 330                 335     


Leu Pro Asn His Lys Ala Asp Ala Val Leu Ser Met Pro Ser Ser Val 
            340                 345                 350         


Thr Ser Gly Leu His Val Gln Pro Ala Leu Ala Val Ser Met Asp Phe 
        355                 360                 365             


Ser Thr Tyr Gly Gly Leu Leu Pro Gln Gly Phe Ile Gln Arg Glu Leu 
    370                 375                 380                 


Phe Ser Lys Leu Gly Glu Leu Ala Val Gly Met Lys Ala Glu Ser Arg 
385                 390                 395                 400 


Ser Val Gly Glu Gln Cys Ser Val Cys Gly Val Glu Leu Pro Asp Asn 
                405                 410                 415     


Glu Ala Val Glu Gln His Arg Lys Leu His Ser Gly Met Lys Thr Tyr 
            420                 425                 430         


Gly Cys Glu Leu Cys Gly Lys Arg Phe Leu Asp Ser Leu Arg Leu Arg 
        435                 440                 445             


Met His Leu Leu Ala His Ser Ala Gly Ala Lys Ala Phe Val Cys Asp 
    450                 455                 460                 


Gln Cys Gly Ala Gln Phe Ser Lys Glu Glu Ala Leu Glu Thr His Arg 
465                 470                 475                 480 


Gln Thr His Thr Gly Thr Asp Met Ala Val Phe Cys Leu Leu Cys Gly 
                485                 490                 495     


Lys Arg Phe Gln Ala Gln Ser Ala Leu Gln Gln His Met Glu Val His 
            500                 505                 510         


Ala Gly Val Arg Ser Tyr Ile Cys Ser Glu Cys Asn Arg Thr Phe Pro 
        515                 520                 525             


Ser His Thr Ala Leu Lys Arg His Leu Arg Ser His Thr Gly Asp His 
    530                 535                 540                 


Pro Tyr Glu Cys Glu Phe Cys Gly Ser Cys Phe Arg Asp Glu Ser Thr 
545                 550                 555                 560 


Leu Lys Ser His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys 
                565                 570                 575     


Asn Gly Cys Gly Lys Lys Phe Ser Leu Lys His Gln Leu Glu Thr His 
            580                 585                 590         


Tyr Arg Val His Thr Gly Glu Lys Pro Phe Glu Cys Lys Leu Cys His 
        595                 600                 605             


Gln Arg Ser Arg Asp Tyr Ser Ala Met Ile Lys His Leu Arg Thr His 
    610                 615                 620                 


Asn Gly Ala Ser Pro Tyr Gln Cys Thr Ile Cys Ser Glu Tyr Cys Pro 
625                 630                 635                 640 


Ser Leu Ser Ser Met Gln Lys His Met Lys Gly His Lys Pro Glu Glu 
                645                 650                 655     


Ile Pro Pro Asp Trp Arg Ile Glu Lys Thr Tyr Leu Tyr Leu Cys Tyr 
            660                 665                 670         


Val 
    


<210>  88
<211>  516
<212>  PRT
<213>  Bos taurus

<400>  88

Met Ala Val Asn Lys Gly Pro Thr Leu Leu Asp Gly Asp Leu Pro Glu 
1               5                   10                  15      


Gln Glu Asn Val Leu Gln Arg Val Leu Gln Leu Pro Val Val Ser Gly 
            20                  25                  30          


Thr Cys Glu Cys Phe Gln Lys Thr Tyr Ala Ser Thr Lys Glu Ala His 
        35                  40                  45              


Pro Leu Val Ala Ser Val Cys Asn Ala Tyr Glu Lys Gly Val Gln Gly 
    50                  55                  60                  


Ala Ser Ser Leu Ala Ala Trp Ser Met Glu Pro Val Val Arg Arg Leu 
65                  70                  75                  80  


Ser Thr Gln Phe Val Ala Ala Asn Glu Leu Ala Cys Arg Gly Leu Asp 
                85                  90                  95      


His Leu Glu Glu Lys Ile Pro Ala Leu Gln Tyr Pro Pro Glu Lys Ile 
            100                 105                 110         


Ala Ser Glu Leu Lys Asp Thr Ile Ser Thr Arg Leu Arg Ser Ala Arg 
        115                 120                 125             


Asn Ser Ile Ser Val Pro Ile Ala Ser Thr Ser Asp Lys Ile Leu Gly 
    130                 135                 140                 


Ala Ala Leu Ala Gly Cys Glu Leu Ala Trp Gly Met Ala Arg Asp Thr 
145                 150                 155                 160 


Ala Glu Tyr Ala Ala Asn Thr Arg Ala Gly Arg Leu Ala Ser Gly Gly 
                165                 170                 175     


Ala Asp Leu Ala Leu Gly Gly Val Glu Lys Met Val Glu Phe Leu Leu 
            180                 185                 190         


Pro Pro Ala Asn Glu Glu Ser Ala Ala Ala Pro Gly Leu Gln Asp Ala 
        195                 200                 205             


Gln Lys Pro Pro Lys Ala Lys Pro Ser Leu Val Ser Arg Val Gly Ala 
    210                 215                 220                 


Leu Ala Asn Thr Leu Ser Arg His Thr Phe Gln Thr Thr Ala Arg Ala 
225                 230                 235                 240 


Leu Lys Gln Gly His Ala Leu Ala Met Trp Ile Pro Gly Val Ala Pro 
                245                 250                 255     


Leu Ser Ser Leu Ala Gln Trp Gly Thr Ser Ala Ala Met Gln Val Val 
            260                 265                 270         


Ser Arg Arg Arg Ser Glu Val Arg Val Pro Trp Leu His Ser Leu Thr 
        275                 280                 285             


Ala Thr Gln Glu Glu Asp His Glu Glu His Thr Asp Thr Asp Gly Glu 
    290                 295                 300                 


Glu Thr Gly Glu Glu Glu Asp Ser Glu Thr Glu Glu Ser Lys Leu Ser 
305                 310                 315                 320 


Glu Gly Ala Ala Leu Pro Gly Ser Gln Gly Leu Leu Gly Ser Val Ala 
                325                 330                 335     


His Thr Leu Gln Lys Ala Leu Gln Ser Thr Val Ser Val Val Met Trp 
            340                 345                 350         


Ala Pro Ala Ala Val Leu Gly Thr Ala Gly Arg Met Leu His Leu Thr 
        355                 360                 365             


Pro Ala Gln Ala Thr Ser Ser Thr Lys Gly Arg Ala Met Ser Leu Ser 
    370                 375                 380                 


Asp Ala Leu Lys Gly Val Thr Asp Asn Val Val Asp Thr Val Val Asn 
385                 390                 395                 400 


Tyr Val Pro Leu Pro Arg Leu Ser Leu Met Glu Pro Glu Ser Glu Phe 
                405                 410                 415     


Arg Asp Ile Asp Asn Pro Pro Ala Glu Ala Glu Arg Arg Glu Ala Glu 
            420                 425                 430         


Arg Arg Gly Ser Gly Ala Pro Pro Ala Cys Pro Glu Pro Ala Pro Arg 
        435                 440                 445             


Pro Ala Pro Pro Arg Gly Ser Leu Arg Ser Ala Arg Gly Leu Gly Ala 
    450                 455                 460                 


Glu Glu Arg Val Asp Ala Thr Ala Leu Pro Arg Ala Ala Phe Pro Ala 
465                 470                 475                 480 


Val Pro Arg Glu Lys Pro Thr Arg Arg Val Ser Asp Ser Phe Phe Arg 
                485                 490                 495     


Pro Ser Val Met Glu Pro Ile Leu Gly Arg Ala Gln Tyr Ser Gln Leu 
            500                 505                 510         


Arg Lys Lys Ser 
        515     


<210>  89
<211>  292
<212>  PRT
<213>  Sus scrofa

<400>  89

Met Ala Ala Ala Ala Tyr Val Asp His Phe Ala Ala Glu Cys Leu Val 
1               5                   10                  15      


Ser Met Ser Ser Arg Ala Val Val His Gly Pro Arg Glu Gly Pro Glu 
            20                  25                  30          


Pro Gly Pro Glu Gly Ala Ala Ala Val Ala Ala Thr Leu Pro His Val 
        35                  40                  45              


Glu Glu Arg Arg Asp Gly Lys Asp Ser Ala Ser Leu Phe Val Val Ala 
    50                  55                  60                  


Arg Ile Leu Ala Asp Leu Asn Gln Gln Ala Pro Ala Pro Val Ser Ala 
65                  70                  75                  80  


Glu Arg Arg Glu Gly Ala Ala Ala Arg Lys Ala Arg Thr Pro Cys Arg 
                85                  90                  95      


Leu Pro Pro Ala Pro Pro Pro Ala Pro Glu Pro Ala Ser Pro Gly Ala 
            100                 105                 110         


Gly Gly Ala Ala Ala Ala Pro Leu Ser Pro Ala Trp Ser Glu Pro Glu 
        115                 120                 125             


Pro Glu Pro Glu Ala Gly Leu Glu Pro Glu Arg Glu Pro Gly Pro Ala 
    130                 135                 140                 


Gly Ser Gly Glu Pro Ser Leu Arg Gln Arg Gly Arg Arg Gly Arg Ser 
145                 150                 155                 160 


Arg Ala Asp Leu Glu Ser Pro Gln Arg Lys His Lys Cys His Tyr Ala 
                165                 170                 175     


Gly Cys Glu Lys Val Tyr Gly Lys Ser Ser His Leu Lys Ala His Leu 
            180                 185                 190         


Arg Thr His Thr Gly Glu Arg Pro Phe Ala Cys Ser Trp Gln Asp Cys 
        195                 200                 205             


Asn Lys Lys Phe Ala Arg Ser Asp Glu Leu Ala Arg His Tyr Arg Thr 
    210                 215                 220                 


His Thr Gly Glu Lys Lys Phe Ser Cys Pro Ile Cys Asp Lys Arg Phe 
225                 230                 235                 240 


Met Arg Ser Asp His Leu Thr Lys His Ala Arg Arg His Ala Asn Phe 
                245                 250                 255     


His Pro Gly Met Leu Gln Arg Arg Gly Gly Gly Ser Arg Thr Gly Ser 
            260                 265                 270         


Leu Ser Asp Tyr Ser Arg Ser Asp Ala Ser Ser Pro Thr Leu Ser Pro 
        275                 280                 285             


Ala Ser Ser Pro 
    290         


<210>  90
<211>  622
<212>  PRT
<213>  Bison bison

<400>  90

Met Pro Pro Gln Leu Ser Asp Gly Leu Asn Tyr Ser Ala Lys Ile Val 
1               5                   10                  15      


Arg Gly Ser Leu Asp Ser Leu Pro Gln Ala Val Arg Glu Phe Val Glu 
            20                  25                  30          


Ser Ser Ala Lys Leu Cys Arg Pro Asp Gln Val His Ile Cys Asp Gly 
        35                  40                  45              


Ser Lys Glu Glu Asn Arg Gln Leu Leu Ser His Met Glu Glu Glu Gly 
    50                  55                  60                  


Val Ile Lys Arg Leu Lys Lys Tyr Asp Asn Cys Trp Leu Ala Leu Thr 
65                  70                  75                  80  


Asp Pro Arg Asp Val Ala Arg Ile Glu Ser Lys Thr Val Ile Ile Thr 
                85                  90                  95      


Arg Glu Gln Arg Asp Thr Val Pro Ile Pro Lys Asn Gly Leu Ser Gln 
            100                 105                 110         


Leu Gly Arg Trp Met Ser Glu Glu Asp Phe Glu Lys Ala Phe Asn Ile 
        115                 120                 125             


Arg Phe Pro Gly Cys Met Lys Gly Arg Thr Met Tyr Val Ile Pro Phe 
    130                 135                 140                 


Ser Met Gly Pro Leu Gly Ser Pro Leu Ser Lys Ile Gly Ile Glu Leu 
145                 150                 155                 160 


Thr Asp Ser Pro Tyr Val Val Thr Ser Met Arg Ile Met Thr Arg Met 
                165                 170                 175     


Gly Thr Ser Val Leu Glu Ala Leu Gly Asp Gly Glu Phe Val Lys Cys 
            180                 185                 190         


Leu His Ser Val Gly Cys Pro Leu Pro Leu Lys Lys Pro Leu Val Asn 
        195                 200                 205             


Asn Trp Ala Cys Asn Pro Glu Leu Thr Leu Ile Ala His Leu Pro Asp 
    210                 215                 220                 


Arg Arg Glu Ile Ile Ser Phe Gly Ser Gly Tyr Gly Gly Asn Ser Leu 
225                 230                 235                 240 


Leu Gly Lys Lys Cys Phe Ala Leu Arg Met Ala Ser Arg Leu Ala Lys 
                245                 250                 255     


Glu Glu Gly Trp Leu Ala Glu His Met Leu Ile Leu Gly Ile Thr Asn 
            260                 265                 270         


Pro Lys Gly Gln Lys Lys Tyr Phe Ala Ala Ala Phe Pro Ser Ala Cys 
        275                 280                 285             


Gly Lys Thr Asn Leu Ala Met Met Asn Pro Thr Leu Pro Gly Trp Lys 
    290                 295                 300                 


Val Glu Cys Val Gly Asp Asp Ile Ala Trp Met Lys Phe Asp Gln Gln 
305                 310                 315                 320 


Gly Asn Leu Arg Ala Ile Asn Pro Glu Asn Gly Phe Phe Gly Val Ala 
                325                 330                 335     


Pro Gly Thr Ser Val Lys Thr Asn Pro Asn Ala Ile Lys Thr Ile Gln 
            340                 345                 350         


Lys Asn Thr Ile Phe Thr Asn Val Ala Glu Thr Ser Asp Gly Gly Val 
        355                 360                 365             


Tyr Trp Glu Gly Ile Asp Gln Pro Leu Ala Ser Gly Ile Lys Leu Ile 
    370                 375                 380                 


Ser Trp Lys Gly Lys Glu Trp Asp Pro Lys Asp Gly Glu Pro Cys Ala 
385                 390                 395                 400 


His Pro Asn Ser Arg Phe Cys Thr Pro Ala Ser Gln Cys Pro Ile Ile 
                405                 410                 415     


Asp Pro Asp Trp Glu Ser Pro Glu Gly Val Pro Ile Glu Gly Ile Ile 
            420                 425                 430         


Phe Gly Gly Arg Arg Pro Val Gly Val Pro Leu Val Tyr Glu Ala Leu 
        435                 440                 445             


Ser Trp Gln His Gly Val Phe Val Gly Ala Ala Met Arg Ser Glu Ala 
    450                 455                 460                 


Thr Ala Ala Ala Glu Tyr Lys Gly Lys Val Ile Met His Asp Pro Phe 
465                 470                 475                 480 


Ala Met Arg Pro Phe Phe Gly Tyr Asn Phe Gly Gln Tyr Leu Ala His 
                485                 490                 495     


Trp Leu Ser Met Ala Gln Arg Pro Ala Ala Lys Leu Pro Lys Ile Phe 
            500                 505                 510         


His Val Asn Trp Phe Arg Lys Asp Lys Ala Gly Arg Phe Leu Trp Pro 
        515                 520                 525             


Gly Phe Gly Glu Asn Ser Arg Val Leu Glu Trp Met Phe Asn Arg Val 
    530                 535                 540                 


Val Gly Glu Gly Gly Ala Lys Leu Thr Pro Ile Gly Tyr Ile Pro Asp 
545                 550                 555                 560 


Glu Asp Ala Leu Asp Leu Arg Gly Leu Gly Asp Val Asp Val Lys Glu 
                565                 570                 575     


Leu Phe His Ile Ser Lys Glu Phe Trp Glu Glu Glu Val Glu Glu Ile 
            580                 585                 590         


Gln Lys Tyr Leu Glu Glu Gln Val Asn Val Asp Leu Pro Pro Glu Ile 
        595                 600                 605             


Lys Asn Gln Val Leu Ala Leu Lys Gln Arg Ile Ser Gln Met 
    610                 615                 620         


<210>  91
<211>  591
<212>  PRT
<213>  Mus musculus

<400>  91

Met Phe Gly Ile Gln Glu Ser Ile Gln Arg Ser Gly Ser Ser Met Lys 
1               5                   10                  15      


Glu Glu Pro Leu Gly Ser Gly Met Asn Ala Val Arg Thr Trp Met Gln 
            20                  25                  30          


Gly Ala Gly Val Leu Asp Ala Asn Thr Ala Ala Gln Ser Gly Val Gly 
        35                  40                  45              


Leu Ala Arg Ala His Phe Glu Lys Gln Pro Pro Ser Asn Leu Arg Lys 
    50                  55                  60                  


Ser Asn Phe Phe His Phe Val Leu Ala Leu Tyr Asp Arg Gln Gly Gln 
65                  70                  75                  80  


Pro Val Glu Ile Glu Arg Thr Ala Phe Val Gly Phe Val Glu Lys Glu 
                85                  90                  95      


Lys Glu Ala Asn Ser Glu Lys Thr Asn Asn Gly Ile His Tyr Arg Leu 
            100                 105                 110         


Gln Leu Leu Tyr Ser Asn Gly Ile Arg Thr Glu Gln Asp Phe Tyr Val 
        115                 120                 125             


Arg Leu Ile Asp Ser Met Thr Lys Gln Ala Ile Val Tyr Glu Gly Gln 
    130                 135                 140                 


Asp Lys Asn Pro Glu Met Cys Arg Val Leu Leu Thr His Glu Ile Met 
145                 150                 155                 160 


Cys Ser Arg Cys Cys Asp Lys Lys Ser Cys Gly Asn Arg Asn Glu Thr 
                165                 170                 175     


Pro Ser Asp Pro Val Ile Ile Asp Arg Phe Phe Leu Lys Phe Phe Leu 
            180                 185                 190         


Lys Cys Asn Gln Asn Cys Leu Lys Asn Ala Gly Asn Pro Arg Asp Met 
        195                 200                 205             


Arg Arg Phe Gln Val Val Val Ser Thr Thr Val Asn Val Asp Gly His 
    210                 215                 220                 


Val Leu Ala Val Ser Asp Asn Met Phe Val His Asn Asn Ser Lys His 
225                 230                 235                 240 


Gly Arg Arg Ala Arg Arg Leu Asp Pro Ser Glu Gly Thr Pro Ser Tyr 
                245                 250                 255     


Leu Glu His Ala Thr Pro Cys Ile Lys Ala Ile Ser Pro Ser Glu Gly 
            260                 265                 270         


Trp Thr Thr Gly Gly Ala Thr Val Ile Ile Ile Gly Asp Asn Phe Phe 
        275                 280                 285             


Asp Gly Leu Gln Val Ile Phe Gly Thr Met Leu Val Trp Ser Glu Leu 
    290                 295                 300                 


Ile Thr Pro His Ala Ile Arg Val Gln Thr Pro Pro Arg His Ile Pro 
305                 310                 315                 320 


Gly Val Val Glu Val Thr Leu Ser Tyr Lys Ser Lys Gln Phe Cys Lys 
                325                 330                 335     


Gly Thr Pro Gly Arg Phe Ile Tyr Thr Ala Leu Asn Glu Pro Thr Ile 
            340                 345                 350         


Asp Tyr Gly Phe Gln Arg Leu Gln Lys Val Ile Pro Arg His Pro Gly 
        355                 360                 365             


Asp Pro Glu Arg Leu Pro Lys Glu Val Ile Leu Lys Arg Ala Ala Asp 
    370                 375                 380                 


Leu Val Glu Ala Leu Tyr Gly Met Pro His Asn Asn Gln Glu Ile Ile 
385                 390                 395                 400 


Leu Lys Arg Ala Ala Asp Ile Ala Glu Ala Leu Tyr Ser Val Pro Arg 
                405                 410                 415     


Asn His Asn Gln Leu Pro Ala Leu Ala Asn Thr Ser Val His Ala Gly 
            420                 425                 430         


Met Met Gly Val Asn Ser Phe Ser Gly Gln Leu Ala Val Asn Val Ser 
        435                 440                 445             


Glu Ala Ser Gln Ala Thr Asn Gln Gly Phe Thr Arg Asn Ser Ser Ser 
    450                 455                 460                 


Val Ser Pro His Gly Tyr Val Pro Ser Thr Thr Pro Gln Gln Thr Asn 
465                 470                 475                 480 


Tyr Asn Ser Val Thr Thr Ser Met Asn Gly Tyr Gly Ser Ala Ala Met 
                485                 490                 495     


Ser Asn Leu Gly Gly Ser Pro Thr Phe Leu Asn Gly Ser Ala Ala Asn 
            500                 505                 510         


Ser Pro Tyr Ala Ile Val Pro Ser Ser Pro Thr Met Ala Ser Ser Thr 
        515                 520                 525             


Ser Leu Pro Ser Asn Cys Ser Ser Ser Ser Gly Ile Phe Ser Phe Ser 
    530                 535                 540                 


Pro Ala Asn Met Val Ser Ala Val Lys Gln Lys Ser Ala Phe Ala Pro 
545                 550                 555                 560 


Val Val Arg Pro Gln Thr Ser Pro Pro Pro Thr Cys Thr Ser Thr Asn 
                565                 570                 575     


Gly Asn Ser Leu Gln Ala Ile Ser Gly Met Ile Val Pro Pro Met 
            580                 585                 590     


<210>  92
<211>  451
<212>  PRT
<213>  Mus musculus

<400>  92

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Gly Gly Pro Ala Leu Ala Ser Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu 
            180                 185                 190         


Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala 
        195                 200                 205             


Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala 
    210                 215                 220                 


Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met 
225                 230                 235                 240 


Gln Asp Ala Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln 
                245                 250                 255     


Ser Tyr Gln Tyr Leu Gly Ser Ile Thr Ser Ser Ser Val His Pro Ala 
            260                 265                 270         


Thr Pro Ile Ser Pro Gly Arg Ala Ser Gly Met Thr Ser Leu Ser Ala 
        275                 280                 285             


Glu Leu Ser Ser Arg Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Gly 
    290                 295                 300                 


Asp Pro Arg Gln Phe Pro Thr Leu Pro Ser Ile Ser Asp Pro Arg Met 
305                 310                 315                 320 


His Tyr Pro Gly Ala Phe Thr Tyr Ser Pro Pro Val Thr Ser Gly Ile 
                325                 330                 335     


Gly Ile Gly Met Ser Ala Met Ser Ser Ala Ser Arg Tyr His Thr Tyr 
            340                 345                 350         


Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ala Gln Ala Gly Pro Phe 
        355                 360                 365             


Gln Thr Gly Ser Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala Gly 
    370                 375                 380                 


Ser Tyr Gln Phe Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg Ile 
385                 390                 395                 400 


Leu Pro Pro Cys Thr Asn Ala Ser Thr Gly Ala Ala Leu Leu Asn Pro 
                405                 410                 415     


Ser Leu Pro Ser Gln Ser Asp Val Val Glu Thr Glu Gly Ser His Ser 
            420                 425                 430         


Asn Ser Pro Thr Asn Met Pro Pro Ala Arg Leu Glu Glu Ala Val Trp 
        435                 440                 445             


Arg Pro Tyr 
    450     


<210>  93
<211>  303
<212>  PRT
<213>  Mus musculus

<400>  93

Met Ala Ala Thr Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Thr Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Ala Ala Gly Gly Gly 
        35                  40                  45              


Leu Pro Val Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 
65                  70                  75                  80  


Ser Arg Thr Asp Arg Asp Ile Lys Val Thr Leu Val Phe Glu His Ile 
                85                  90                  95      


Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Val Glu Thr Ile Lys Asp Leu Met Arg Gln Phe Leu Ser Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Thr Ser Asn Gly Thr Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Thr Pro Val Val Val 
                165                 170                 175     


Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 
            180                 185                 190         


Thr Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 
        195                 200                 205             


Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 
    210                 215                 220                 


Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro Arg 
225                 230                 235                 240 


Glu Val Ser Leu Pro Arg Gly Ala Phe Ala Pro Arg Gly Pro Arg Pro 
                245                 250                 255     


Val Gln Ser Val Val Pro Glu Met Glu Glu Ser Gly Ala Gln Leu Leu 
            260                 265                 270         


Leu Glu Met Leu Thr Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 
        275                 280                 285             


Ala Leu Gln His Ser Tyr Leu His Lys Glu Glu Ser Asp Ala Glu 
    290                 295                 300             


<210>  94
<211>  296
<212>  PRT
<213>  Mus musculus

<400>  94

Met His Arg Leu Leu Ala Trp Asp Ala Ala Cys Leu Pro Pro Pro Pro 
1               5                   10                  15      


Ala Ala Phe Arg Pro Met Glu Val Ala Asn Phe Tyr Tyr Glu Pro Asp 
            20                  25                  30          


Cys Leu Ala Tyr Gly Ala Lys Ala Ala Arg Ala Ala Pro Arg Ala Pro 
        35                  40                  45              


Ala Ala Glu Pro Ala Ile Gly Glu His Glu Arg Ala Ile Asp Phe Ser 
    50                  55                  60                  


Pro Tyr Leu Glu Pro Leu Ala Pro Ala Ala Asp Phe Ala Ala Pro Ala 
65                  70                  75                  80  


Pro Ala His His Asp Phe Leu Ser Asp Leu Phe Ala Asp Asp Tyr Gly 
                85                  90                  95      


Ala Lys Pro Ser Lys Lys Pro Ala Asp Tyr Gly Tyr Val Ser Leu Gly 
            100                 105                 110         


Arg Ala Gly Ala Lys Ala Ala Pro Pro Ala Cys Phe Pro Pro Pro Pro 
        115                 120                 125             


Pro Ala Ala Leu Lys Ala Glu Pro Gly Phe Glu Pro Ala Asp Cys Lys 
    130                 135                 140                 


Arg Ala Asp Asp Ala Pro Ala Met Ala Ala Gly Phe Pro Phe Ala Leu 
145                 150                 155                 160 


Arg Ala Tyr Leu Gly Tyr Gln Ala Thr Pro Ser Gly Ser Ser Gly Ser 
                165                 170                 175     


Leu Ser Thr Ser Ser Ser Ser Ser Pro Pro Gly Thr Pro Ser Pro Ala 
            180                 185                 190         


Asp Ala Lys Ala Ala Pro Ala Ala Cys Phe Ala Gly Pro Pro Ala Ala 
        195                 200                 205             


Pro Ala Lys Ala Lys Ala Lys Lys Thr Val Asp Lys Leu Ser Asp Glu 
    210                 215                 220                 


Tyr Lys Met Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser Arg 
225                 230                 235                 240 


Asp Lys Ala Lys Met Arg Asn Leu Glu Thr Gln His Lys Val Leu Glu 
                245                 250                 255     


Leu Thr Ala Glu Asn Glu Arg Leu Gln Lys Lys Val Glu Gln Leu Ser 
            260                 265                 270         


Arg Glu Leu Ser Thr Leu Arg Asn Leu Phe Lys Gln Leu Pro Glu Pro 
        275                 280                 285             


Leu Leu Ala Ser Ala Gly His Cys 
    290                 295     


<210>  95
<211>  328
<212>  PRT
<213>  Gallus gallus

<400>  95

Met Gln Arg Leu Val Ala Trp Asp Ala Ala Cys Leu Pro Ile Gln Pro 
1               5                   10                  15      


Pro Ala Phe Lys Ser Met Glu Val Ala Asn Phe Tyr Tyr Glu Ala Asp 
            20                  25                  30          


Cys Leu Ala Ala Leu Asn Lys Leu His Pro Arg Ala Ala Gly Gly Arg 
        35                  40                  45              


Ser Met Thr Glu Leu Thr Val Gly Asp His Glu Arg Ala Ile Asp Phe 
    50                  55                  60                  


Ser Pro Tyr Leu Asp Pro Leu Ala Ala Ser Gln Gln Pro Ala Gln Pro 
65                  70                  75                  80  


Pro Pro Pro Ala Ala Ala Ala Gly Gly Asn Phe Glu Pro Ala Cys Ser 
                85                  90                  95      


Ser Gly Gly Gln Asp Phe Leu Ser Asp Leu Phe Ala Glu Asp Tyr Lys 
            100                 105                 110         


Gly Ser Gly Gly Gly Lys Lys Pro Asp Tyr Thr Tyr Ile Ser Leu Thr 
        115                 120                 125             


Arg His Gly His Pro Cys Gly Ser Gln Ser His Lys Pro Gly Val Leu 
    130                 135                 140                 


Pro Gly Cys Phe Pro Pro Gln Ile Val Glu Thr Lys Val Glu Pro Val 
145                 150                 155                 160 


Phe Glu Thr Leu Asp Ser Cys Lys Gly Pro Arg Lys Glu Glu Gly Gly 
                165                 170                 175     


Ala Gly Pro Gly Pro Gly Gly Met Ser Ser Pro Tyr Gly Ser Thr Val 
            180                 185                 190         


Arg Ser Tyr Leu Gly Tyr Gln Ser Val Pro Ser Gly Ser Ser Gly Asn 
        195                 200                 205             


Leu Ser Thr Ser Ser Ser Ser Ser Pro Pro Gly Thr Pro Asn Pro Ser 
    210                 215                 220                 


Glu Ser Ser Lys Ser Ala Ala Gly Ala Gly Gly Tyr Ser Gly Pro Pro 
225                 230                 235                 240 


Ala Gly Lys Asn Lys Pro Lys Lys Cys Val Asp Lys His Ser Asp Glu 
                245                 250                 255     


Tyr Lys Leu Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser Arg 
            260                 265                 270         


Asp Lys Ala Lys Met Arg Asn Leu Glu Thr Gln His Lys Val Leu Glu 
        275                 280                 285             


Leu Thr Ala Glu Asn Glu Arg Leu Gln Lys Lys Val Glu Gln Leu Ser 
    290                 295                 300                 


Arg Glu Leu Ser Thr Leu Arg Asn Leu Phe Lys Gln Leu Pro Glu Pro 
305                 310                 315                 320 


Leu Leu Ala Ser Ser Pro Arg Cys 
                325             


<210>  96
<211>  307
<212>  PRT
<213>  Capra hircus

<400>  96

Met Gln Arg Leu Val Ala Trp Asp Pro Ala Cys Leu Pro Leu Pro Pro 
1               5                   10                  15      


Pro Pro Pro Ala Phe Lys Ser Met Glu Val Ala Asn Phe Tyr Tyr Glu 
            20                  25                  30          


Ala Asp Cys Leu Ala Ala Ala Tyr Gly Gly Lys Ala Ala Pro Ala Ala 
        35                  40                  45              


Pro Pro Ala Ala Arg Pro Gly Ile Gly Glu His Glu Arg Ala Ile Asp 
    50                  55                  60                  


Phe Ser Pro Tyr Leu Glu Pro Leu Gly Ala Pro Gln Ala Ala Pro Pro 
65                  70                  75                  80  


Ala Pro Ala Pro Ala Pro Ala Ser Ser Gly Gln His His Asp Phe Leu 
                85                  90                  95      


Ser Asp Leu Phe Ser Asp Asp Tyr Gly Gly Lys Asn Cys Lys Lys Ala 
            100                 105                 110         


Ala Glu Tyr Gly Tyr Val Ser Leu Gly Arg Leu Gly Ala Ala Lys Gly 
        115                 120                 125             


Ala Leu His Pro Gly Cys Phe Leu Lys Ala Glu Pro Gly Phe Glu Pro 
    130                 135                 140                 


Ala Asp Cys Lys Arg Lys Glu Glu Ala Gly Ala Pro Gly Gly Gly Ala 
145                 150                 155                 160 


Ala Gly Met Ala Ala Gly Phe Pro Tyr Ala Leu Arg Ala Tyr Leu Gly 
                165                 170                 175     


Tyr Gln Ala Val Pro Ser Gly Ser Ser Gly Ser Leu Ser Thr Ser Ser 
            180                 185                 190         


Ser Ser Ser Pro Pro Gly Thr Pro Ser Pro Ala Asp Ala Lys Ala Pro 
        195                 200                 205             


Pro Ala Ala Ala Ala Cys Tyr Ala Gly Ala Ala Pro Val Lys Ser Lys 
    210                 215                 220                 


Ala Lys Lys Thr Val Asp Lys His Ser Asp Glu Tyr Lys Ile Arg Arg 
225                 230                 235                 240 


Glu Arg Asn Asn Ile Ala Val Arg Lys Ser Arg Asp Lys Ala Lys Met 
                245                 250                 255     


Arg Asn Leu Glu Thr Gln His Lys Val Leu Glu Leu Thr Ala Glu Asn 
            260                 265                 270         


Glu Arg Leu Gln Lys Lys Val Glu Gln Leu Ser Arg Glu Leu Ser Thr 
        275                 280                 285             


Leu Arg Asn Leu Phe Lys Gln Leu Pro Glu Pro Leu Leu Ala Ser Ser 
    290                 295                 300                 


Gly His Cys 
305         


<210>  97
<211>  348
<212>  PRT
<213>  Bos taurus

<400>  97

Met Gln Arg Leu Val Val Trp Asp Pro Val Cys Leu Pro Leu Pro Pro 
1               5                   10                  15      


Pro Pro Pro Ala Phe Lys Ser Met Glu Val Ala Asn Phe Tyr Tyr Glu 
            20                  25                  30          


Ala Asp Cys Leu Ala Ala Ala Tyr Gly Gly Lys Ala Ala Pro Ala Ala 
        35                  40                  45              


Pro Pro Ala Asp Arg Pro Gly Pro Arg Pro Pro Thr Gly Glu Leu Gly 
    50                  55                  60                  


Ser Ile Gly Glu His Glu Arg Ala Ile Asp Phe Ser Pro Tyr Leu Glu 
65                  70                  75                  80  


Pro Leu Gly Ala Pro Gln Ala Pro Ala Pro Thr Thr Ala Ser Asp Thr 
                85                  90                  95      


Phe Glu Ala Ala Pro Ser Ala Pro Ala Pro Val Pro Ala Ser Ser Gly 
            100                 105                 110         


Gln His His Asp Phe Leu Ser Asp Leu Phe Ser Asp Asp Tyr Gly Gly 
        115                 120                 125             


Lys Asn Cys Lys Lys Ala Ala Glu Tyr Gly Tyr Val Ser Leu Gly Arg 
    130                 135                 140                 


Leu Gly Ala Ala Lys Gly Ala Leu His Pro Gly Cys Phe Ala Pro Leu 
145                 150                 155                 160 


His Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Glu Leu Lys Ala Glu 
                165                 170                 175     


Pro Gly Phe Glu Pro Ala Asp Cys Lys Arg Lys Glu Glu Ala Gly Ala 
            180                 185                 190         


Pro Gly Gly Gly Ala Ala Gly Met Ala Ala Gly Phe Pro Tyr Ala Leu 
        195                 200                 205             


Arg Ala Tyr Leu Gly Tyr Gln Ala Val Pro Ser Gly Ser Ser Gly Ser 
    210                 215                 220                 


Leu Ser Thr Ser Ser Ser Ser Ser Pro Pro Gly Thr Pro Ser Pro Ala 
225                 230                 235                 240 


Asp Ala Lys Ala Thr Pro Ala Ala Ala Ala Cys Tyr Ala Gly Ala Ala 
                245                 250                 255     


Pro Ala Pro Ser Gln Val Lys Ser Lys Ala Lys Lys Thr Val Asp Lys 
            260                 265                 270         


His Ser Asp Glu Tyr Lys Ile Arg Arg Glu Arg Asn Asn Ile Ala Val 
        275                 280                 285             


Arg Lys Ser Arg Asp Lys Ala Lys Met Arg Asn Leu Glu Thr Gln His 
    290                 295                 300                 


Lys Val Leu Glu Leu Thr Gly Glu Asn Glu Arg Leu Gln Lys Lys Val 
305                 310                 315                 320 


Glu Gln Leu Ser Arg Glu Val Ser Thr Leu Arg Asn Leu Phe Lys Thr 
                325                 330                 335     


Leu Pro Glu Pro Leu Leu Ala Ser Ser Gly His Cys 
            340                 345             


<210>  98
<211>  575
<212>  PRT
<213>  Mus musculus

<400>  98

Met Phe Gly Ile Gln Asp Thr Leu Gly Arg Gly Pro Ala Leu Lys Asp 
1               5                   10                  15      


Lys Ser Leu Gly Ala Glu Met Asp Ser Val Arg Ser Trp Val Arg Asn 
            20                  25                  30          


Val Gly Val Val Asp Ala Asn Val Ala Ala Gln Ser Gly Val Ala Leu 
        35                  40                  45              


Ser Arg Ala His Phe Glu Lys Gln Pro Pro Ser Asn Leu Arg Lys Ser 
    50                  55                  60                  


Asn Phe Phe His Phe Val Leu Ala Leu Tyr Asp Arg Gln Gly Gln Pro 
65                  70                  75                  80  


Val Glu Ile Glu Arg Thr Ala Phe Val Asp Phe Val Glu Asn Asp Lys 
                85                  90                  95      


Glu Gln Gly Asn Glu Lys Thr Asn Asn Gly Thr His Tyr Lys Leu Gln 
            100                 105                 110         


Leu Leu Tyr Ser Asn Gly Val Arg Thr Glu Gln Asp Leu Tyr Val Arg 
        115                 120                 125             


Leu Ile Asp Ser Val Thr Lys Gln Pro Ile Ala Tyr Glu Gly Gln Asn 
    130                 135                 140                 


Lys Asn Pro Glu Met Cys Arg Val Leu Leu Thr His Glu Val Met Cys 
145                 150                 155                 160 


Ser Arg Cys Cys Glu Lys Lys Ser Cys Gly Asn Arg Asn Glu Thr Pro 
                165                 170                 175     


Ser Asp Pro Val Ile Ile Asp Arg Phe Phe Leu Lys Phe Phe Leu Lys 
            180                 185                 190         


Cys Asn Gln Asn Cys Leu Lys Thr Ala Gly Asn Pro Arg Asp Met Arg 
        195                 200                 205             


Arg Phe Gln Val Val Leu Ser Thr Thr Val Asn Val Asp Gly His Val 
    210                 215                 220                 


Leu Ala Val Ser Asp Asn Met Phe Val His Asn Asn Ser Lys His Gly 
225                 230                 235                 240 


Arg Arg Ala Arg Arg Leu Asp Pro Ser Glu Ala Thr Pro Cys Ile Lys 
                245                 250                 255     


Ala Ile Ser Pro Ser Glu Gly Trp Thr Thr Gly Gly Ala Met Val Ile 
            260                 265                 270         


Ile Ile Gly Asp Asn Phe Phe Asp Gly Leu Gln Val Val Phe Gly Thr 
        275                 280                 285             


Met Leu Val Trp Ser Glu Leu Ile Thr Pro His Ala Ile Arg Val Gln 
    290                 295                 300                 


Thr Pro Pro Arg His Ile Pro Gly Val Val Glu Val Thr Leu Ser Tyr 
305                 310                 315                 320 


Lys Ser Lys Gln Phe Cys Lys Gly Ala Pro Gly Arg Phe Ile Tyr Thr 
                325                 330                 335     


Ala Leu Asn Glu Pro Thr Ile Asp Tyr Gly Phe Gln Arg Leu Gln Lys 
            340                 345                 350         


Val Ile Pro Arg His Pro Gly Asp Pro Glu Arg Leu Ala Lys Glu Met 
        355                 360                 365             


Leu Leu Lys Arg Ala Ala Asp Leu Val Glu Ala Leu Tyr Gly Thr Pro 
    370                 375                 380                 


His Asn Asn Gln Asp Ile Ile Leu Lys Arg Ala Ala Asp Ile Ala Glu 
385                 390                 395                 400 


Ala Leu Tyr Ser Val Pro Arg Asn Pro Ser Gln Ile Pro Ala Leu Ser 
                405                 410                 415     


Ser Ser Pro Ala His Ser Gly Met Met Gly Ile Asn Ser Tyr Gly Ser 
            420                 425                 430         


Gln Leu Gly Val Ser Ile Ser Glu Ser Thr Gln Gly Asn Asn Gln Gly 
        435                 440                 445             


Tyr Ile Arg Asn Thr Ser Ser Ile Ser Pro Arg Gly Tyr Ser Ser Ser 
    450                 455                 460                 


Ser Thr Pro Gln Gln Ser Asn Tyr Ser Thr Ser Ser Asn Ser Met Asn 
465                 470                 475                 480 


Gly Tyr Ser Asn Val Pro Met Ala Asn Leu Gly Val Pro Gly Ser Pro 
                485                 490                 495     


Gly Phe Leu Asn Gly Ser Pro Thr Gly Ser Pro Tyr Gly Ile Met Ser 
            500                 505                 510         


Ser Ser Pro Thr Val Gly Ser Ser Ser Thr Ser Ser Ile Leu Pro Phe 
        515                 520                 525             


Ser Ser Ser Val Phe Pro Ala Val Lys Gln Lys Ser Ala Phe Ala Pro 
    530                 535                 540                 


Val Ile Arg Pro Gln Gly Ser Pro Ser Pro Ala Cys Ser Ser Gly Asn 
545                 550                 555                 560 


Gly Asn Gly Phe Arg Ala Met Thr Gly Leu Val Val Pro Pro Met 
                565                 570                 575 


<210>  99
<211>  596
<212>  PRT
<213>  Mus musculus

<400>  99

Met Phe Gly Ile Gln Glu Asn Ile Pro Arg Gly Gly Thr Thr Met Lys 
1               5                   10                  15      


Glu Glu Pro Leu Gly Ser Gly Met Asn Pro Val Arg Ser Trp Met His 
            20                  25                  30          


Thr Ala Gly Val Val Asp Ala Asn Thr Ala Ala Gln Ser Gly Val Gly 
        35                  40                  45              


Leu Ala Arg Ala His Phe Glu Lys Gln Pro Pro Ser Asn Leu Arg Lys 
    50                  55                  60                  


Ser Asn Phe Phe His Phe Val Leu Ala Leu Tyr Asp Arg Gln Gly Gln 
65                  70                  75                  80  


Pro Val Glu Ile Glu Arg Thr Ala Phe Val Asp Phe Val Glu Lys Glu 
                85                  90                  95      


Lys Glu Pro Asn Asn Glu Lys Thr Asn Asn Gly Ile His Tyr Lys Leu 
            100                 105                 110         


Gln Leu Leu Tyr Ser Asn Gly Val Arg Thr Glu Gln Asp Leu Tyr Val 
        115                 120                 125             


Arg Leu Ile Asp Ser Met Thr Lys Gln Ala Ile Val Tyr Glu Gly Gln 
    130                 135                 140                 


Asp Lys Asn Pro Glu Met Cys Arg Val Leu Leu Thr His Glu Ile Met 
145                 150                 155                 160 


Cys Ser Arg Cys Cys Asp Lys Lys Ser Cys Gly Asn Arg Asn Glu Thr 
                165                 170                 175     


Pro Ser Asp Pro Val Ile Ile Asp Arg Phe Phe Leu Lys Phe Phe Leu 
            180                 185                 190         


Lys Cys Asn Gln Asn Cys Leu Lys Asn Ala Gly Asn Pro Arg Asp Met 
        195                 200                 205             


Arg Arg Phe Gln Val Val Val Ser Thr Thr Val Asn Val Asp Gly His 
    210                 215                 220                 


Val Leu Ala Val Ser Asp Asn Met Phe Val His Asn Asn Ser Lys His 
225                 230                 235                 240 


Gly Arg Arg Ala Arg Arg Leu Asp Pro Ser Glu Gly Thr Ala Pro Ser 
                245                 250                 255     


Tyr Leu Glu Asn Ala Thr Pro Cys Ile Lys Ala Ile Ser Pro Ser Glu 
            260                 265                 270         


Gly Trp Thr Thr Gly Gly Ala Thr Val Ile Ile Ile Gly Asp Asn Phe 
        275                 280                 285             


Phe Asp Gly Leu Gln Val Val Phe Gly Thr Met Leu Val Trp Ser Glu 
    290                 295                 300                 


Leu Ile Thr Pro His Ala Ile Arg Val Gln Thr Pro Pro Arg His Ile 
305                 310                 315                 320 


Pro Gly Val Val Glu Val Thr Leu Ser Tyr Lys Ser Lys Gln Phe Cys 
                325                 330                 335     


Lys Gly Ala Pro Gly Arg Phe Val Tyr Thr Ala Leu Asn Glu Pro Thr 
            340                 345                 350         


Ile Asp Tyr Gly Phe Gln Arg Leu Gln Lys Val Ile Pro Arg His Pro 
        355                 360                 365             


Gly Asp Pro Glu Arg Leu Pro Lys Glu Val Leu Leu Lys Arg Ala Ala 
    370                 375                 380                 


Asp Leu Val Glu Ala Leu Tyr Gly Met Pro His Asn Asn Gln Glu Ile 
385                 390                 395                 400 


Ile Leu Lys Arg Ala Ala Asp Ile Ala Glu Ala Leu Tyr Ser Val Pro 
                405                 410                 415     


Arg Asn His Asn Gln Ile Pro Thr Leu Gly Asn Thr Pro Ala His Thr 
            420                 425                 430         


Gly Met Met Gly Val Asn Ser Phe Ser Ser Gln Leu Ala Val Asn Val 
        435                 440                 445             


Ser Glu Thr Ser Gln Ala Asn Asp Gln Val Gly Tyr Ser Arg Asn Thr 
    450                 455                 460                 


Ser Ser Val Ser Pro Arg Gly Tyr Val Pro Ser Ser Thr Pro Gln Gln 
465                 470                 475                 480 


Ser Asn Tyr Asn Thr Val Ser Thr Ser Met Asn Gly Tyr Gly Ser Gly 
                485                 490                 495     


Ala Met Ala Asn Leu Gly Val Pro Gly Ser Pro Gly Phe Leu Asn Gly 
            500                 505                 510         


Ser Ser Ala Asn Ser Pro Tyr Gly Ile Val Pro Ser Ser Pro Thr Met 
        515                 520                 525             


Ala Ala Ser Ser Val Thr Leu Pro Ser Asn Cys Ser Ser Thr His Gly 
    530                 535                 540                 


Ile Phe Ser Phe Ser Pro Ala Asn Val Ile Ser Ala Val Lys Gln Lys 
545                 550                 555                 560 


Ser Ala Phe Ala Pro Val Val Arg Pro Gln Ala Ser Pro Pro Pro Ser 
                565                 570                 575     


Cys Thr Ser Ala Asn Gly Asn Gly Leu Gln Ala Met Ser Gly Leu Val 
            580                 585                 590         


Val Pro Pro Met 
        595     


