                         SEQUENCE LISTING

<110>  The Jackson Laboratory
 
<120>  THERAPEUTICS TARGETING TRANSFORMING GROWTH FACTOR BETA  FAMILY 
       SIGNALING

<130>  J0227.70098WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/227,232
<151>  2021-07-29

<150>  US 63/113,575
<151>  2020-11-13

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  4654
<212>  DNA
<213>  Homo sapiens

<400>  1
gggcgctgct gggctgcggc ggcggcggcg gcggcggtgg ttactatggc ggagtcggcc       60

ggagcctcct ccttcttccc ccttgttgtc ctcctgctcg ccggcagcgg cgggtccggg      120

ccccgggggg tccaggctct gctgtgtgcg tgcaccagct gcctccaggc caactacacg      180

tgtgagacag atggggcctg catggtttcc attttcaatc tggatgggat ggagcaccat      240

gtgcgcacct gcatccccaa agtggagctg gtccctgccg ggaagccctt ctactgcctg      300

agctcggagg acctgcgcaa cacccactgc tgctacactg actactgcaa caggatcgac      360

ttgagggtgc ccagtggtca cctcaaggag cctgagcacc cgtccatgtg gggcccggtg      420

gagctggtag gcatcatcgc cggcccggtg ttcctcctgt tcctcatcat catcattgtt      480

ttccttgtca ttaactatca tcagcgtgtc tatcacaacc gccagagact ggacatggaa      540

gatccctcat gtgagatgtg tctctccaaa gacaagacgc tccaggatct tgtctacgat      600

ctctccacct cagggtctgg ctcagggtta cccctctttg tccagcgcac agtggcccga      660

accatcgttt tacaagagat tattggcaag ggtcggtttg gggaagtatg gcggggccgc      720

tggaggggtg gtgatgtggc tgtgaaaata ttctcttctc gtgaagaacg gtcttggttc      780

agggaagcag agatatacca gacggtcatg ctgcgccatg aaaacatcct tggatttatt      840

gctgctgaca ataaagcaga ctgctcattc ctcacattgc catgggaagt tgtaatggtc      900

tctgctgccc ccaagctgag gagccttaga ctccaataca agggaggaag gggaagagca      960

agatttttat tcccactgaa taatggcacc tggacacagc tgtggcttgt ttctgactat     1020

catgagcacg ggtccctgtt tgattatctg aaccggtaca cagtgacaat tgaggggatg     1080

attaagctgg ccttgtctgc tgctagtggg ctggcacacc tgcacatgga gatcgtgggc     1140

acccaaggga agcctggaat tgctcatcga gacttaaagt caaagaacat tctggtgaag     1200

aaaaatggca tgtgtgccat agcagacctg ggcctggctg tccgtcatga tgcagtcact     1260

gacaccattg acattgcccc gaatcagagg gtggggacca aacgatacat ggcccctgaa     1320

gtacttgatg aaaccattaa tatgaaacac tttgactcct ttaaatgtgc tgatatttat     1380

gccctcgggc ttgtatattg ggagattgct cgaagatgca attctggagg agtccatgaa     1440

gaatatcagc tgccatatta cgacttagtg ccctctgacc cttccattga ggaaatgcga     1500

aaggttgtat gtgatcagaa gctgcgtccc aacatcccca actggtggca gagttatgag     1560

gcactgcggg tgatggggaa gatgatgcga gagtgttggt atgccaacgg cgcagcccgc     1620

ctgacggccc tgcgcatcaa gaagaccctc tcccagctca gcgtgcagga agacgtgaag     1680

atctaactgc tccctctctc cacacggagc tcctggcagc gagaactacg cacagctgcc     1740

gcgttgagcg tacgatggag gcctacctct cgtttctgcc cagccctctg tggccaggag     1800

ccctggcccg caagagggac agagcccggg agagactcgc tcactcccat gttgggtttg     1860

agacagacac cttttctatt tacctcctaa tggcatggag actctgagag cgaattgtgt     1920

ggagaactca gtgccacacc tcgaactggt tgtagtggga agtcccgcga aacccggtgc     1980

atctggcacg tggccaggag ccatgacagg ggcgcttggg aggggccgga ggaaccgagg     2040

tgttgccagt gctaagctgc cctgagggtt tccttcgggg accagcccac agcacaccaa     2100

ggtggcccgg aagaaccaga agtgcagccc ctctcacagg cagctctgag ccgcgctttc     2160

ccctcctccc tgggatggac gctgccggga gactgccagt ggagacggaa tctgccgctt     2220

tgtctgtcca gccgtgtgtg catgtgccga ggtgcgtccc ccgttgtgcc tggttcgtgc     2280

catgccctta cacgtgcgtg tgagtgtgtg tgtgtgtctg taggtgcgca cttacctgct     2340

tgagctttct gtgcatgtgc aggtcggggg tgtggtcgtc atgctgtccg tgcttgctgg     2400

tgcctctttt cagtagtgag cagcatctag tttccctggt gcccttccct ggaggtctct     2460

ccctccccca gagcccctca tgccacagtg gtactctgtg tctggcaggc tactctgccc     2520

accccagcat cagcacagct ctcctcctcc atctcagact gtggaaccaa agctggccca     2580

gttgtccatg acaaaagagg cttttgggcc aaaatgtgag ggtggtgggt gggatgggca     2640

gggaaggaat cctggtggaa gtcttgggtg ttagtgtcag ccatgggaaa tgagccagcc     2700

caagggcatc atcctcagca gcatcgagga agggccgagg aatgtgaagc cagatctcgg     2760

gactcagatt ggaatgttac atctgtcttt catctcccag atcctggaaa cagcagtgta     2820

tatttttggt ggtggtgggt ttggggtggg gaagggaagg gcgggcaagg agtggggagg     2880

gagtctgggg tgggagggag gcatctgcat gggtcttctt ttactggact gtctgatcag     2940

ggtggaggga aggtgagagg tttgcatcca cttcaggagc cctactgaag ggaacagcct     3000

gagccgaaca tgttatttaa cctgagtata gtatttaacg aagcctagaa gcacggctgt     3060

gggtggtgat ttggtcagca tatcttaggt atataataac tttgaagcca taacttttaa     3120

ctggagtggt ttgatttctt tttttaattt tattgggagg gtttggattt taactttttt     3180

taatgttgtt aaatattaag tttttgtaaa aggaaaacca tctctgtgat tacctctcaa     3240

tctatttgtt tttaaagaaa tccctaaaaa aaaaaattat ccaattgaac gcacatagct     3300

caatcacact ggaaatgttt gtccttgcac ctgagcctgt tcccactcag cagtgagagt     3360

tcctctttgc cctgaggctc agtctctctc gtattttgtc cccaccccca attccttgag     3420

tggtttttgc tctagggccc tttcttgcac tgtccagctg gttgtaccct ctccaggcat     3480

ttattcaaca aatgtgggtg aagtgcctgc tgggtgccag gtgctgggaa tacatctgtg     3540

gacaagacat gcttgggtcc tactcctgga gcactgtaaa aagagctgat tcaagtaagt     3600

agatgcctgt tttgagacca gaaggtttca taattggttc tacgaccctt ttgagcctag     3660

aattattgtt cttatataag atcactgaag aaagaggaac ccccacaacc ccctccacaa     3720

agagaccagg ggcgggtgat gagacctggg gtttagaacc ccaggtgaga cctcaaatca     3780

ctgcattcat tctgagcccc cttcctgtcc ccaggggagg tgtattgtgt atgtagcctt     3840

agagcatctc tgcctccaac ccagcagttc tctgccaaag cttgtggagg agggagagcc     3900

ctgtccctgc cctcaggctc cccagtgctc ctggcccttc tatttatttg actgattatt     3960

gcttctttcc ttgcattaaa ggagatcttc ccctaacctt tgggccaatt tactggccac     4020

taatttcgtt taaataccat tgtgtcattg gggggaccgt ctttacccct gctgacctcc     4080

cacctatccg ccctgcagca gaaccttggc ggtttatagg taatgatgga acttagactc     4140

ctcttcccag agtcacaagt agcctctggg atctgccaac acacgtccac tcccaagcca     4200

ctagcccact ccccagttgg cccttctgcc cttaccccac acacagtcca actcttccac     4260

ctctggggaa gatggagcag gtctttggga agctcccaca cccacctctg ccactcttaa     4320

cactaagtga gagttgggga gaaactgaag ccgtgttttt ggccccccga ggctaaccct     4380

gatccatagt gctacctgca cctctggatt ctggattcac agaccaagtc caagcccgtt     4440

cttacgtcgc cataaaggcc cccgaacggc attctcggta cttctgtttg tttttgtaca     4500

ttttattaga aaggactgta aaatagccac ttagacactt tacctcttca gtatgcaaat     4560

gtaaataaat tgtaatatag gaaatctttt gttttaatat aagaatgagc ctgtccaatt     4620

tctgctgtac attattaaaa gttttattca caga                                 4654


<210>  2
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Ser Ala Gly Ala Ser Ser Phe Phe Pro Leu Val Val Leu 
1               5                   10                  15      


Leu Leu Ala Gly Ser Gly Gly Ser Gly Pro Arg Gly Val Gln Ala Leu 
            20                  25                  30          


Leu Cys Ala Cys Thr Ser Cys Leu Gln Ala Asn Tyr Thr Cys Glu Thr 
        35                  40                  45              


Asp Gly Ala Cys Met Val Ser Ile Phe Asn Leu Asp Gly Met Glu His 
    50                  55                  60                  


His Val Arg Thr Cys Ile Pro Lys Val Glu Leu Val Pro Ala Gly Lys 
65                  70                  75                  80  


Pro Phe Tyr Cys Leu Ser Ser Glu Asp Leu Arg Asn Thr His Cys Cys 
                85                  90                  95      


Tyr Thr Asp Tyr Cys Asn Arg Ile Asp Leu Arg Val Pro Ser Gly His 
            100                 105                 110         


Leu Lys Glu Pro Glu His Pro Ser Met Trp Gly Pro Val Glu Leu Val 
        115                 120                 125             


Gly Ile Ile Ala Gly Pro Val Phe Leu Leu Phe Leu Ile Ile Ile Ile 
    130                 135                 140                 


Val Phe Leu Val Ile Asn Tyr His Gln Arg Val Tyr His Asn Arg Gln 
145                 150                 155                 160 


Arg Leu Asp Met Glu Asp Pro Ser Cys Glu Met Cys Leu Ser Lys Asp 
                165                 170                 175     


Lys Thr Leu Gln Asp Leu Val Tyr Asp Leu Ser Thr Ser Gly Ser Gly 
            180                 185                 190         


Ser Gly Leu Pro Leu Phe Val Gln Arg Thr Val Ala Arg Thr Ile Val 
        195                 200                 205             


Leu Gln Glu Ile Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly 
    210                 215                 220                 


Arg Trp Arg Gly Gly Asp Val Ala Val Lys Ile Phe Ser Ser Arg Glu 
225                 230                 235                 240 


Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu 
                245                 250                 255     


Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn 
            260                 265                 270         


Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly 
        275                 280                 285             


Ser Leu Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Ile Glu Gly Met 
    290                 295                 300                 


Ile Lys Leu Ala Leu Ser Ala Ala Ser Gly Leu Ala His Leu His Met 
305                 310                 315                 320 


Glu Ile Val Gly Thr Gln Gly Lys Pro Gly Ile Ala His Arg Asp Leu 
                325                 330                 335     


Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Met Cys Ala Ile Ala 
            340                 345                 350         


Asp Leu Gly Leu Ala Val Arg His Asp Ala Val Thr Asp Thr Ile Asp 
        355                 360                 365             


Ile Ala Pro Asn Gln Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu 
    370                 375                 380                 


Val Leu Asp Glu Thr Ile Asn Met Lys His Phe Asp Ser Phe Lys Cys 
385                 390                 395                 400 


Ala Asp Ile Tyr Ala Leu Gly Leu Val Tyr Trp Glu Ile Ala Arg Arg 
                405                 410                 415     


Cys Asn Ser Gly Gly Val His Glu Glu Tyr Gln Leu Pro Tyr Tyr Asp 
            420                 425                 430         


Leu Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg Lys Val Val Cys 
        435                 440                 445             


Asp Gln Lys Leu Arg Pro Asn Ile Pro Asn Trp Trp Gln Ser Tyr Glu 
    450                 455                 460                 


Ala Leu Arg Val Met Gly Lys Met Met Arg Glu Cys Trp Tyr Ala Asn 
465                 470                 475                 480 


Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln 
                485                 490                 495     


Leu Ser Val Gln Glu Asp Val Lys Ile 
            500                 505 


<210>  3
<211>  6261
<212>  DNA
<213>  Homo sapiens

<400>  3
ggcggctagg gaggtggggc gaggcgaggt ttgctggggt gaggcagcgg cgcggccggg       60

ccgggccggg ccacaggcgg tggcggcggg accatggagg cggcggtcgc tgctccgcgt      120

ccccggctgc tcctcctcgt gctggcggcg gcggcggcgg cggcggcggc gctgctcccg      180

ggggcgacgg cgttacagtg tttctgccac ctctgtacaa aagacaattt tacttgtgtg      240

acagatgggc tctgctttgt ctctgtcaca gagaccacag acaaagttat acacaacagc      300

atgtgtatag ctgaaattga cttaattcct cgagataggc cgtttgtatg tgcaccctct      360

tcaaaaactg ggtctgtgac tacaacatat tgctgcaatc aggaccattg caataaaata      420

gaacttccaa ctactggttt accattgctt gttcagagaa caattgcgag aactattgtg      480

ttacaagaaa gcattggcaa aggtcgattt ggagaagttt ggagaggaaa gtggcgggga      540

gaagaagttg ctgttaagat attctcctct agagaagaac gttcgtggtt ccgtgaggca      600

gagatttatc aaactgtaat gttacgtcat gaaaacatcc tgggatttat agcagcagac      660

aataaagaca atggtacttg gactcagctc tggttggtgt cagattatca tgagcatgga      720

tccctttttg attacttaaa cagatacaca gttactgtgg aaggaatgat aaaacttgct      780

ctgtccacgg cgagcggtct tgcccatctt cacatggaga ttgttggtac ccaaggaaag      840

ccagccattg ctcatagaga tttgaaatca aagaatatct tggtaaagaa gaatggaact      900

tgctgtattg cagacttagg actggcagta agacatgatt cagccacaga taccattgat      960

attgctccaa accacagagt gggaacaaaa aggtacatgg cccctgaagt tctcgatgat     1020

tccataaata tgaaacattt tgaatccttc aaacgtgctg acatctatgc aatgggctta     1080

gtattctggg aaattgctcg acgatgttcc attggtggaa ttcatgaaga ttaccaactg     1140

ccttattatg atcttgtacc ttctgaccca tcagttgaag aaatgagaaa agttgtttgt     1200

gaacagaagt taaggccaaa tatcccaaac agatggcaga gctgtgaagc cttgagagta     1260

atggctaaaa ttatgagaga atgttggtat gccaatggag cagctaggct tacagcattg     1320

cggattaaga aaacattatc gcaactcagt caacaggaag gcatcaaaat gtaattctac     1380

agctttgcct gaactctcct tttttcttca gatctgctcc tgggttttaa tttgggaggt     1440

caattgttct acctcactga gagggaacag aaggatattg cttccttttg cagcagtgta     1500

ataaagtcaa ttaaaaactt cccaggattt ctttggaccc aggaaacagc catgtgggtc     1560

ctttctgtgc actatgaacg cttctttccc aggacagaaa atgtgtagtc tacctttatt     1620

ttttattaac aaaacttgtt ttttaaaaag atgattgctg gtcttaactt taggtaactc     1680

tgctgtgctg gagatcatct ttaagggcaa aggagttgga ttgctgaatt acaatgaaac     1740

atgtcttatt actaaagaaa gtgatttact cctggttagt acattctcag aggattctga     1800

accactagag tttccttgat tcagactttg aatgtactgt tctatagttt ttcaggatct     1860

taaaactaac acttataaaa ctcttatctt gagtctaaaa atgacctcat atagtagtga     1920

ggaacataat tcatgcaatt gtattttgta tactattatt gttctttcac ttattcagaa     1980

cattacatgc cttcaaaatg ggattgtact ataccagtaa gtgccacttc tgtgtctttc     2040

taatggaaat gagtagaatt gctgaaagtc tctatgttaa aacctatagt gtttgaattc     2100

aaaaagctta tttatctggg taacccaaac tttttctgtt ttgtttttgg aagggttttt     2160

gtggtatgtc atttggtatt ctattctgaa aatgcctttc tcctaccaaa atgtgcttaa     2220

gccactaaag aaatgaagtg gcattaatta gtaaattatt agcatggtca tgtttgaata     2280

ttctcacatc aagcttttgc attttaattg tgttgtctaa gtatactttt aaaaaatcaa     2340

gtggcactct agatgcttat agtactttaa tatttgtagc atacagacta atttttctaa     2400

aagggaaagt ctgtctagct gcttgtgaaa agttatgtgg tattctgtaa gccatttttt     2460

tctttatctg ttcaaagact tattttttaa gacatgaatt acatttaaaa ttagaatatg     2520

gttaatatta aataataggc ctttttctag gaaggcgaag gtagttaata atttgaatag     2580

ataacagatg tgcaagaaag tcacatttgt tatgtatgta ggagtaaacg ttcggtggat     2640

cctctgtctt tgtaactgag gttagagcta gtgtggtttt gaggtctcac tacactttga     2700

ggaaggcagc ttttaattca gtgtttcctt atgtgtgcgt acattgcaac tgcttacatg     2760

taatttatgt aatgcattca gtgcaccctt gttacttggg agaggtggta gctaaagaac     2820

attctgagta taggtttttc tccatttaca gatgtctttg gtcaaatatt gaaagcaaac     2880

ttgtcatggt cttcttacat taagttgaaa ctagcttata ataactggtt tttacttcca     2940

atgctatgaa gtctctgcag ggcttttaca gttttcgaag tccttttatc actgtgatct     3000

tattctgagg ggagaaaaaa ctatcatagc tctgaggcaa gacttcgact ttatagtgct     3060

atcagttccc cgatacaggg tcagagtaac ccatacagta ttttggtcag gaagagaaag     3120

tggccattta cactgaatga gttgcattct gataatgtct tatctcttat acgtagaata     3180

aatttgaaag actatttgat cttaaaacca aagtaatttt agaatgagtg acatattaca     3240

taggaattta gtgtcaattt catgtgttta aaaacatcat gggaaaaatg cttagaggtt     3300

actattttga ctacaaagtt gagttttttt ctgtagttac cataatttca ttgaagcaaa     3360

tgaatgagtt tgagaggttt gtttttatag ttgtgttgta ttacttgttt aataataatc     3420

tctaattctg tgatcaggta ctttttttgt gggggttttt tttttgtttt tttttttttg     3480

ttgttgtttt tgggccattt ctaagcctac cagatctgct ttatgaaatc caggggacca     3540

atgcatttta tcactaaaac tatttttata taattttaag aatataccaa aagttgtctg     3600

atttaaagtt gtaatacatg atttctcact ttcatgtaag gttatccact tttgctgaag     3660

atatttttta ttgaatcaaa gattgagtta caattatact tttcttacct aagtggataa     3720

aatgtacttt tgatgaatca gggaattttt ttaaagttgg agtttagttc taaattgact     3780

ttacgtatta ctgcagttaa ttcctttttt ggctagggat ggtttgataa accacaattg     3840

gctgatattg aaaatgaaag aaacttaaaa ggtgggatgg atcatgatta ctgtcgataa     3900

ctgcagataa atttgattag agtaataatt ttgtcattta aaaacacagt tgtttatact     3960

gcccatccta ggatgctcac cttccaagat tcaacgtggc taaaacatct tctggtaaat     4020

tgtgcgtcca tattcatttt gtcagtagcc aggagaaatg gggatggggg aaatacgact     4080

tagtgaggca tagacatccc tggtccatcc tttctgtctc cagctgtttc ttggaacctg     4140

ctctcctgct tgctggtccc tgacgcagag accgttgcct cccccacagc cgtttgactg     4200

aaggctgctc tggagaccta gagtaaaacg gctgatggaa gttgtgggac ccacttccat     4260

ttccttcagt cattagaggt ggaagggagg ggtctccaag tttggagatt gagcagatga     4320

ggcttgggat gcccctgctt tgacttcagc catggatgag gagtgggatg gcagcaaggt     4380

ggctcctgtg gcagtggagt tgtgccagaa acagtggcca gttgtatcgc ctataagaca     4440

gggtaaggtc tgaagagctg agcctgtaat tctgctgtaa taatgatagt gctcaagaag     4500

tgccttgagt tggtgtacag tgccatggcc atcaagaatc ccagatttca ggttttatta     4560

caaaatgtaa gtggtcactt ggcgattttg tagtacatgc atgagttacc ttttttctct     4620

atgtctgaga actgtcagat taaaacaaga tggcaaagag atcgttagag tgcacaacaa     4680

aatcactatc ccattagaca catcatcaaa agcttatttt tattcttgca ctggaagaat     4740

cgtaagtcaa ctgtttcttg accatggcag tgttctggct ccaaatggta gtgattccaa     4800

ataatggttc tgttaacact ttggcagaaa atgccagctc agatattttg agatactaag     4860

gattatcttt ggacatgtac tgcagcttct tgtctctgtt ttggattact ggaataccca     4920

tgggccctct caagagtgct ggacttctag gacattaaga tgattgtcag tacattaaac     4980

ttttcaatcc cattatgcaa tcttgtttgt aaatgtaaac ttctaaaaat atggttaata     5040

acattcaacc tgtttattac aacttaaaag gaacttcagt gaatttgttt ttatttttta     5100

acaagatttg tgaactgaat atcatgaacc atgttttgat accccttttt cacgttgtgc     5160

caacggaata gggtgtttga tatttcttca tatgttaagg agatgcttca aaatgtcaat     5220

tgctttaaac ttaaattacc tctcaagaga ccaaggtaca tttacctcat tgtgtatata     5280

atgtttaata tttgtcagag cattctccag gtttgcagtt ttatttctat aaagtatggg     5340

tattatgttg ctcagttact caaatggtac tgtattgttt atatttgtac cccaaataac     5400

atcgtctgta ctttctgttt tctgtattgt atttgtgcag gattctttag gctttatcag     5460

tgtaatctct gccttttaag atatgtacag aaaatgtcca tataaatttc cattgaagtc     5520

gaatgatact gagaagcctg taaagaggag aaaaaaacat aagctgtgtt tccccataag     5580

tttttttaaa ttgtatattg tatttgtagt aatattccaa aagaatgtaa ataggaaata     5640

gaagagtgat gcttatgtta agtcctaaca ctacagtaga agaatggaag cagtgcaaat     5700

aaattacatt tttcccaagt gccagtggca tattttaaaa taaagtgtat acgttggaat     5760

gagtcatgcc atatgtagtt gctgtagatg gcaactagaa cctttgagtt acaagagtct     5820

ttagaagttt tctaaccctg cctagtgcaa gttacaatat tatagcgtgt tcggggagtg     5880

ccctcctgtc tgcaggtgtg tctctgtgcc tgggggcttt tctccacatg cttaggggtg     5940

tgggtcttcc attggggcat gatggacctg tctacaggtg atctctgttg cctttgggtc     6000

agcacatttg ttagtctcct gggggtgaaa acttggctta caagagaact ggaaaaatga     6060

tgagatgtgg tccccaaacc cttgattgac tctggggagg ggctttgtga ataggattgc     6120

tctcacatta aagatagtta cttcaatttg aaggctggat ttagggattt ttttttttcc     6180

ttataacaaa gacatcacca ggatatgaag cttttgttga aagttggaaa aaaagtgaaa     6240

ttaaagacat tcccagacaa a                                               6261


<210>  4
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Cys His Asn Arg Thr Val Ile His His Arg Val Pro Asn 
145                 150                 155                 160 


Glu Glu Asp Pro Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr 
                165                 170                 175     


Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile Val Leu Gln 
        195                 200                 205             


Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp 
    210                 215                 220                 


Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg 
225                 230                 235                 240 


Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His 
                245                 250                 255     


Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr 
            260                 265                 270         


Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu 
        275                 280                 285             


Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys 
    290                 295                 300                 


Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His Met Glu Ile 
305                 310                 315                 320 


Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser 
                325                 330                 335     


Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu 
            340                 345                 350         


Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala 
        355                 360                 365             


Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu 
    370                 375                 380                 


Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Asp 
385                 390                 395                 400 


Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg Arg Cys Ser 
                405                 410                 415     


Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val 
            420                 425                 430         


Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln 
        435                 440                 445             


Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu 
    450                 455                 460                 


Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala 
465                 470                 475                 480 


Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser 
                485                 490                 495     


Gln Gln Glu Gly Ile Lys Met 
            500             


<210>  5
<211>  5214
<212>  DNA
<213>  Homo sapiens

<400>  5
gtctgggctt ccgaatatgt tttatgacgg ttgattttac accaggaggt ttgtctccga       60

ggaagaccca gggaactgga tatctagcga gaacttcctc cggattcccc ggcgcctcgg      120

gaaaatggga gctgctgcaa agttggcgtt tgccgtcttt cttatctcct gttcttcagg      180

tgctatactt ggtagatcag aaactcagga gtgtcttttc tttaatgcta attgggaaaa      240

agacagaacc aatcaaactg gtgttgaacc gtgttatggt gacaaagata aacggcggca      300

ttgttttgct acctggaaga atatttctgg ttccattgaa atagtgaaac aaggttgttg      360

gctggatgat atcaactgct atgacaggac tgattgtgta gaaaaaaaag acagccctga      420

agtatatttt tgttgctgtg agggcaatat gtgtaatgaa aagttttctt attttccgga      480

gatggaagtc acacagccca cttcaaatcc agttacacct aagccaccct attacaacat      540

cctgctctat tccttggtgc cacttatgtt aattgcgggg attgtcattt gtgcattttg      600

ggtgtacagg catcacaaga tggcctaccc tcctgtactt gttccaactc aagacccagg      660

accaccccca ccttctccat tactaggttt gaaaccactg cagttattag aagtgaaagc      720

aaggggaaga tttggttgtg tctggaaagc ccagttgctt aacgaatatg tggctgtcaa      780

aatatttcca atacaggaca aacagtcatg gcaaaatgaa tacgaagtct acagtttgcc      840

tggaatgaag catgagaaca tattacagtt cattggtgca gaaaaacgag gcaccagtgt      900

tgatgtggat ctttggctga tcacagcatt tcatgaaaag ggttcactat cagactttct      960

taaggctaat gtggtctctt ggaatgaact gtgtcatatt gcagaaacca tggctagagg     1020

attggcatat ttacatgagg atatacctgg cctaaaagat ggccacaaac ctgccatatc     1080

tcacagggac atcaaaagta aaaatgtgct gttgaaaaac aacctgacag cttgcattgc     1140

tgactttggg ttggccttaa aatttgaggc tggcaagtct gcaggcgata cccatggaca     1200

ggttggtacc cggaggtaca tggctccaga ggtattagag ggtgctataa acttccaaag     1260

ggatgcattt ttgaggatag atatgtatgc catgggatta gtcctatggg aactggcttc     1320

tcgctgtact gctgcagatg gacctgtaga tgaatacatg ttgccatttg aggaggaaat     1380

tggccagcat ccatctcttg aagacatgca ggaagttgtt gtgcataaaa aaaagaggcc     1440

tgttttaaga gattattggc agaaacatgc tggaatggca atgctctgtg aaaccattga     1500

agaatgttgg gatcacgacg cagaagccag gttatcagct ggatgtgtag gtgaaagaat     1560

tacccagatg cagagactaa caaatattat taccacagag gacattgtaa cagtggtcac     1620

aatggtgaca aatgttgact ttcctcccaa agaatctagt ctatgatggt tgcgccatct     1680

gtgcacacta agaaatggga ctctgaactg gagctgctaa gctaaagaaa ctgcttacag     1740

tttattttct gtgtaaaatg agtaggatgt ctcttggaaa tgttaagaaa gaagaccctt     1800

tgttgaaaaa tgttgctctg ggagacttac tgcattgccg acagcacaga tgtgaaggac     1860

atgagactaa gagaaacctt gcaaactcta taaagaaact tttgaaaaag tgtacatgaa     1920

gaatgtagcc ctctccaaat caaggatctt ttggacctgg ctaatggagt gtttgaaaac     1980

tgacatcaga tttcttaatg tctgtcagaa gacactaatt ccttaaatga actactgcta     2040

ttttttttaa atcaaaaact tttcatttca gattttaaaa agggtaactt gtttttattg     2100

catttgctgt tgtttctata aatgactatt gtaatgccaa tatgacacag cttgtgaatg     2160

tttagtgtgc tgctgttctg tgtacataaa gtcatcaaag tggggtacag taaagaggct     2220

tccaagcatt actttaacct ccctcaacaa ggtatacctc agttccacgg ttgctaaatt     2280

ataaaattga aaacactaac aaaatttgaa taataaatcg atccatgttt tgtaacaaat     2340

tcactgtgtt atttaaggaa aaaaaggtaa gctatgctta gtgccaacaa taagtggcca     2400

ttcgtaaagc agtgttttag catttcttgt gctggcttgt aatgtaggga aaaaaagtgc     2460

tgttttttga aaagatggtg tcatttcccc cttcttccca tgttttaaag ccccatctta     2520

tatccagttc ccaaaatttg catacttacc taagtatttt ttttaggtgt gctgtgtttg     2580

gggaatattt gaaaatttaa agcatgattt aaaatttttt aaagtgagct gtgacactgg     2640

aaagctcttc attttatctt ttaaaataga gttttttcta tttatatatg taaaattgta     2700

gtgtatttct tttcaccaaa cagtgtgtgg gacattcttt atcactgttt taggatcacc     2760

tcaggaagtg tcgttaccca gaattcccca ctgtctgcta tgagacttgt aactttatca     2820

ctatacttct gcttggtgcc atcttgtcag agtaatattt gatgtctgtg atatgtaaag     2880

aattatccta ggataaagat attaaacttt aagcagattt cagatgttac tgctttaaaa     2940

caaatcaggg ataacaaatt aaacgtataa cttaaaatat gcaatgacat ttagaggtaa     3000

ccaatgttga tataggtagc atagcctagc ctcctcccca aaattgcttt tacaactaac     3060

actgatacta atttaggata gttcatgcct tatccttgct aagaaaatgg aattgatggt     3120

aggcaggtgc taaagtgctt ttcaaaacaa tattacgtta gaatacaatt ggattcttcc     3180

tcaaatttat acaggccaaa aagtaaaaca ttaattttct gaatttccag attaccaatc     3240

aattaatcaa caaatagcca gtattatgct gtgtatttct gtcaggtcat tttaaaatcc     3300

atgttaattt tataaaagaa ttttttacat gtcactgtca ggagctcact gtgaatgtgt     3360

tgtcttcaaa tggttattta accacacagt acactacatt ttacatatat gtacgtaatc     3420

tctgggaata gtaaattaat tatgttattt ataaacaata cataggtcaa cagactttaa     3480

gcagggagga aaagaagagt aatagcgtct gtgtgctgca gaccattcag aactgtcacg     3540

tgtgtcccca tggtctcatt cattgtattc ctagcaattc ccttttcaat gttgagttca     3600

cctctttatt tcacaaagta cttggtctct caatttcttg atctggtttt gcttccattt     3660

aaaaactaat caagaaggga aaatattgag aatgtgcata caagaaaatc attaatttcc     3720

tgaagatgaa tttctacctg ttgtgaacat ttaactttct ttttaaaagt taaacaaaaa     3780

taaacaaggg atattatgat gaatgtttgg cttatgtgag tactagagat aaaattttta     3840

aacccagtta ttcacaatat aaaatgtttt caagttagaa aaaattttta gaaatcctgg     3900

gtattgtatt taactgtagc taaccaattt taaaacttgt attcttttga gaactattat     3960

taatagaaaa actttttata agcagtaaaa taagaatgtt ccagtgacta cctgtcctta     4020

tacctagtct tgttaaaact ttcttttgca gggtatttag tgtttggttt acagtcagtg     4080

cagagtgggc aagttaacag aaagtttgag ctagagatac tggaaaaaaa aaagatcaaa     4140

gaatgagaaa aatggtgatc cattttgggg caaactgaga ccccccaaat aactctttcc     4200

tcatgtgtat ggtgctcctc atgactcgtc ttgtattttg cctttctgat acccatcaga     4260

actgctgctg ctctaactta tactctttac cttgcccaga tctccgcgta aggaatgctt     4320

tatgatcaac ttgccatagg actgatggat taaccagtgt tcggctttat ttgaagtcta     4380

tgccctgcac agctcttgta tgtattttag atgctagaag tttttttagc atgtgatgtg     4440

tgattcttgt ttgaattcta ggtaccttgt gaattccaga aaaagagact gtgcttcacg     4500

attgttagtc ccatgaactt gcactatcta tctttcatgg tgatgttttg aaaatacaat     4560

caggaaaaaa cccaacacct ttggaattta aaatagaatc atatcatgaa atttaaaaag     4620

aatctcttct gttgcatttc ctcaccccta agtaacagct acatttaagt aaaatgcagg     4680

tggtagggga aaaaaaacca tggcgagatg gtggtttagt ggaataaact gattactggt     4740

ttttttgttt tttttttttt ttttaaagaa agaagcttca tcacagatac tttccagttt     4800

ctcttttata cttttttgaa agattacttt ttaggaacat ttggtatgat atgcataaaa     4860

ttatttatcc atttatgggc aaaatgatac aagtagcatc ttgattgaac atcatttacc     4920

tcagatattc aaccagcagt acgtttttta tgcagtctca acccatatcc catttgttac     4980

ctctcagaat attggtaagc agttattttc gctttactct gtatttcttg tgttttgggc     5040

acaggttatt gtactactgt caaatcgtac ttgctatttt ttctgcaagt atttaacaga     5100

aagcttaaaa tccccataaa accccacctt ggataagtga ttgttaaata ttgtacaaat     5160

aaaatgtatg ctatccccat tccatcccca agttaaataa aaaaatgaat acgg           5214


<210>  6
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Ala Ala Ala Lys Leu Ala Phe Ala Val Phe Leu Ile Ser Cys 
1               5                   10                  15      


Ser Ser Gly Ala Ile Leu Gly Arg Ser Glu Thr Gln Glu Cys Leu Phe 
            20                  25                  30          


Phe Asn Ala Asn Trp Glu Lys Asp Arg Thr Asn Gln Thr Gly Val Glu 
        35                  40                  45              


Pro Cys Tyr Gly Asp Lys Asp Lys Arg Arg His Cys Phe Ala Thr Trp 
    50                  55                  60                  


Lys Asn Ile Ser Gly Ser Ile Glu Ile Val Lys Gln Gly Cys Trp Leu 
65                  70                  75                  80  


Asp Asp Ile Asn Cys Tyr Asp Arg Thr Asp Cys Val Glu Lys Lys Asp 
                85                  90                  95      


Ser Pro Glu Val Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu 
            100                 105                 110         


Lys Phe Ser Tyr Phe Pro Glu Met Glu Val Thr Gln Pro Thr Ser Asn 
        115                 120                 125             


Pro Val Thr Pro Lys Pro Pro Tyr Tyr Asn Ile Leu Leu Tyr Ser Leu 
    130                 135                 140                 


Val Pro Leu Met Leu Ile Ala Gly Ile Val Ile Cys Ala Phe Trp Val 
145                 150                 155                 160 


Tyr Arg His His Lys Met Ala Tyr Pro Pro Val Leu Val Pro Thr Gln 
                165                 170                 175     


Asp Pro Gly Pro Pro Pro Pro Ser Pro Leu Leu Gly Leu Lys Pro Leu 
            180                 185                 190         


Gln Leu Leu Glu Val Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys 
        195                 200                 205             


Ala Gln Leu Leu Asn Glu Tyr Val Ala Val Lys Ile Phe Pro Ile Gln 
    210                 215                 220                 


Asp Lys Gln Ser Trp Gln Asn Glu Tyr Glu Val Tyr Ser Leu Pro Gly 
225                 230                 235                 240 


Met Lys His Glu Asn Ile Leu Gln Phe Ile Gly Ala Glu Lys Arg Gly 
                245                 250                 255     


Thr Ser Val Asp Val Asp Leu Trp Leu Ile Thr Ala Phe His Glu Lys 
            260                 265                 270         


Gly Ser Leu Ser Asp Phe Leu Lys Ala Asn Val Val Ser Trp Asn Glu 
        275                 280                 285             


Leu Cys His Ile Ala Glu Thr Met Ala Arg Gly Leu Ala Tyr Leu His 
    290                 295                 300                 


Glu Asp Ile Pro Gly Leu Lys Asp Gly His Lys Pro Ala Ile Ser His 
305                 310                 315                 320 


Arg Asp Ile Lys Ser Lys Asn Val Leu Leu Lys Asn Asn Leu Thr Ala 
                325                 330                 335     


Cys Ile Ala Asp Phe Gly Leu Ala Leu Lys Phe Glu Ala Gly Lys Ser 
            340                 345                 350         


Ala Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro 
        355                 360                 365             


Glu Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg 
    370                 375                 380                 


Ile Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Ala Ser Arg 
385                 390                 395                 400 


Cys Thr Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu 
                405                 410                 415     


Glu Glu Ile Gly Gln His Pro Ser Leu Glu Asp Met Gln Glu Val Val 
            420                 425                 430         


Val His Lys Lys Lys Arg Pro Val Leu Arg Asp Tyr Trp Gln Lys His 
        435                 440                 445             


Ala Gly Met Ala Met Leu Cys Glu Thr Ile Glu Glu Cys Trp Asp His 
    450                 455                 460                 


Asp Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Gly Glu Arg Ile Thr 
465                 470                 475                 480 


Gln Met Gln Arg Leu Thr Asn Ile Ile Thr Thr Glu Asp Ile Val Thr 
                485                 490                 495     


Val Val Thr Met Val Thr Asn Val Asp Phe Pro Pro Lys Glu Ser Ser 
            500                 505                 510         


Leu 
    


<210>  7
<211>  11782
<212>  DNA
<213>  Homo sapiens

<400>  7
ggctcggctc cgtggccgcc gctcaggagc cattttggac tcggttcagc tcccctcccc       60

cccacccctc cccccgttca tggcccctcc ggactcggcc cctgcgcccg gggcccgggc      120

ccagccccgc cgcgctatgc ctgagtcggg cgcgccccgg cccgtgcccc gccgccgccc      180

cccggccccc gcgtcgcccc ggagcccggg ccgcagcctg cgccgcccgc agcggccctg      240

agcccggccc cgccgaccgg cccttggagc ccgaacgctg ctcggggacg aaggcgcagg      300

aagcgcgcag ggaacgagac cgaaggaagg agcgggaagg agagcgcagc cgccgcctgg      360

ccctgcgcgc cccgggagcg ccgtgcggcc ctgcccgcgg gctccgggtg tgcgcggggc      420

ggcgccgcgg aacatgacgg cgccctgggt ggccctcgcc ctcctctggg gatcgctgtg      480

cgccggctct gggcgtgggg aggctgagac acgggagtgc atctactaca acgccaactg      540

ggagctggag cgcaccaacc agagcggcct ggagcgctgc gaaggcgagc aggacaagcg      600

gctgcactgc tacgcctcct ggcgcaacag ctctggcacc atcgagctcg tgaagaaggg      660

ctgctggcta gatgacttca actgctacga taggcaggag tgtgtggcca ctgaggagaa      720

cccccaggtg tacttctgct gctgtgaagg caacttctgc aacgaacgct tcactcattt      780

gccagaggct gggggcccgg aagtcacgta cgagccaccc ccgacagccc ccaccctgct      840

cacggtgctg gcctactcac tgctgcccat cgggggcctt tccctcatcg tcctgctggc      900

cttttggatg taccggcatc gcaagccccc ctacggtcat gtggacatcc atgaggaccc      960

tgggcctcca ccaccatccc ctctggtggg cctgaagcca ctgcagctgc tggagatcaa     1020

ggctcggggg cgctttggct gtgtctggaa ggcccagctc atgaatgact ttgtagctgt     1080

caagatcttc ccactccagg acaagcagtc gtggcagagt gaacgggaga tcttcagcac     1140

acctggcatg aagcacgaga acctgctaca gttcattgct gccgagaagc gaggctccaa     1200

cctcgaagta gagctgtggc tcatcacggc cttccatgac aagggctccc tcacggatta     1260

cctcaagggg aacatcatca catggaacga actgtgtcat gtagcagaga cgatgtcacg     1320

aggcctctca tacctgcatg aggatgtgcc ctggtgccgt ggcgagggcc acaagccgtc     1380

tattgcccac agggacttta aaagtaagaa tgtattgctg aagagcgacc tcacagccgt     1440

gctggctgac tttggcttgg ctgttcgatt tgagccaggg aaacctccag gggacaccca     1500

cggacaggta ggcacgagac ggtacatggc tcctgaggtg ctcgagggag ccatcaactt     1560

ccagagagat gccttcctgc gcattgacat gtatgccatg gggttggtgc tgtgggagct     1620

tgtgtctcgc tgcaaggctg cagacggacc cgtggatgag tacatgctgc cctttgagga     1680

agagattggc cagcaccctt cgttggagga gctgcaggag gtggtggtgc acaagaagat     1740

gaggcccacc attaaagatc actggttgaa acacccgggc ctggcccagc tttgtgtgac     1800

catcgaggag tgctgggacc atgatgcaga ggctcgcttg tccgcgggct gtgtggagga     1860

gcgggtgtcc ctgattcgga ggtcggtcaa cggcactacc tcggactgtc tcgtttccct     1920

ggtgacctct gtcaccaatg tggacctgcc ccctaaagag tcaagcatct aagcccagga     1980

catgagtgtc tgtccagact cagtggatct gaagaaaaaa ggaaaaaaag ttgtgttttg     2040

ttttggaaat cccataaaac caacaaacac ataaaatgca gctgctattt taccttgact     2100

ttttattatt attattataa ttattataat tattattatt aatattattt tttggattgg     2160

atcagttttt accagcatat tgctctactg tatcacaaac agcggacacg tcagcaggcg     2220

ttgaggtgct gagctgtgga tgcagaacca gcgccatgct gaagagcctc agccacctcc     2280

tgtcctttgg gattcgtttt tcccgctttc tctttgtttg tcgtctcaga atctgtgaca     2340

caaagaaacc catctcctgt cttaggaaac ctaatgctgc aaactctacc tagaggaacc     2400

tttgaagact gttacataag aacatacctt cctcagaaga ggagtttcct ctgccctctg     2460

cccttctccc ctgcctccct ccctcccctc cttttatttt gttttagtga gcttaagaaa     2520

cagcagatgt gtctttcacg gatctaacgg gtgttgtcct gatcgagaaa aaaactggga     2580

tgagaatggt ttggactgga gttggaaggg gaggacggta ctgggggtag ggtttggaac     2640

agagctacac tggactcggg cacattcgga gcagcatcct ttagtatgga ggctacttct     2700

caggtaacca ggaattgagg ggaaggacct tgtggaggcc gagcattaac agcaagagcg     2760

gggtttggag aaagtctgag attgggtgca gccctgactt acctgctggc cctgaccagt     2820

ttcttttcac taacttggcc ttgggcatag gatgaaacat tttttctgcc ctaattttaa     2880

aactaggtga gggtagaatc atcacaggtt aggaatacat tcttcataag acacgatgct     2940

gtaaataccc ttaatggacg aaaagttgaa atacttttgt ttcctcttgg agcagttcag     3000

ggaaatgccc acaggggatt gtcctgcaca gatagggcaa gaggatttcc tgggtggagt     3060

ctgccaaggc ctgcctcgct ggggacccca gagtcctgca cctctggttc cgccccaggt     3120

ggtgacatta ctgtccccgt tctgtggctc gtggacaaga ctttctccag accccttaaa     3180

gtggtacata ttctaaaaaa ctgtttttct attatgccat aaccttgctc tagtcagtga     3240

atgttcctaa tgctgctgtt tcaacatttg aattcttttt aatttatgaa acatgctaaa     3300

tttttttttt caaacaaaac acacacatcc acatatacac atgcttcgct atgtggcttc     3360

caaggtttaa attttgaaaa gtaaaagaat taaaacttca cgaccacaga tcacctcaaa     3420

ccagaaatac ctcagaattt tctacttatg taaggtttat tatatatttt gttagttgtg     3480

ttgtcttgta gtaagtatat tttaatgtaa gttggctttt gtgacaagga agtttaaaag     3540

aaatagagaa aaagaaaaaa gtttgcatct tctagggagt gctaccattt ttgtttgata     3600

acgccccctt gtaaataatt gtcatcaact gtaggttggc tgtctgggcc aagtctgggc     3660

atttatcagt cttgtttgtg aaggcttttc cttctggttt ctttagatca ttttatttaa     3720

aaacagtgca tctcttcatc gtgagggtag gcaaggcggg ggccgtgggg agaggttgac     3780

ctgggtgaga actgaagagg ccgcctcctc ttgggttgtt tggagcttca catgtaattc     3840

acatgtaaca tgtaacttga tcggtcagtg ttcagaatga caagtaaccc cgcttaaact     3900

tggtagaagg atggccctta gacctgaatg gggtgatttt acttgggatt taacttcttc     3960

agcaaattaa cagcaacgtt ggaagagatc tgtggcgcct ctgtgaagca caccgtgact     4020

caggccagtc ttttagtgca gcgtgtctgg gagtgaaggg ttttgccctt gctggtcttg     4080

gagtccacag tgtgaggggc actgcacatg cctgggcatc tacctagtgt gctatgttca     4140

gtgtctgggg cttactgccc cggggtcctt tcctctgggt gttggggcac agggtgctat     4200

gggaggccca tttgcttccc tctcggagct cagtttttgc ttcatgggtc aaaatgtggg     4260

ctggccaagt ggttacagga acagggtttc ggtaagctat gttgtctttt tttttttttt     4320

tttttttttt tttaatggtt tgattttgtg ctgtggtatt ttttttccct tagaataatt     4380

tttaatggca aaacaggcct tacagcagtt gcttttcttt accatttatt tctttaagaa     4440

gctttaaaat atttattgaa aagtgccata tctaatttct ttagctttcg cctcaggcag     4500

tgcaggcatc tttacttttc atcctcagaa gaaacaaacg actaacaaat gtagcaaatt     4560

tactgcagga atagttaggt catgatacta cctgaacact aaaccccagc ctctttgttt     4620

ggttttagtt cctctgggtg gtttttcttt tgtgtgctgg cttgattctt gtgagaagtt     4680

ttgacctggc caagggaggg ttgagccatg gttctggtgt gggactttgc ggtcaagaca     4740

cagtacagac aggtcaggcc tgcgtgcctt ttctctgggt ggcctccccg ttaggcccac     4800

cgtacgctca gccactatag tgtccctgtg gggccttgcc atcagattgt gtgtcaggag     4860

atggtacctt tttggtgtgg ctggggagga gtgtggtcca tgccagttct ttgggcttca     4920

ggccactctt cccctcatgc tgtggtgtaa agtgcaccca tcaggtggta tatctggttc     4980

tgatggcaag aagaaggtgg gggatctcct tatagggcat gggtctagga gcacagatgg     5040

gccttttgcc ccgggtaaat gcttgtctgt ttgctgtcat gtgttctttg aggagtgagc     5100

catctcgagc cctgctttga atttactggg tcatagagcc tctgcctgtg ctcttttcca     5160

taatgacttc atgtgacatg cacttttggt gggctcagat aattggtttc tttttgtttt     5220

tgacctcagg ctctgtggca gactggggaa aatggggcct ggcatcattt tccctgtcaa     5280

tgggaggggc tgttccatgc agggtgggag gggaccaagt tagcagagag tagccaagga     5340

tccttgcttc ttcctttcta gtgtgctgtc atccaagcag gctcctggct gtagggatgg     5400

gccttgggga agaatcttct ttgaaagcat ctatgataac tgagaagtca tccctagttg     5460

gagaaatcca gtaatgagca gaaggaggaa gcaagtgagg acagaggcca ttgtattaca     5520

gtgtcacgca gagggccctc aatgatgggg cattggggaa ggctgtagac atagtcatca     5580

gaacatcctg gcctggcata agctgggttt tctcctggga ccattggtcc tcagcaggag     5640

ttctttgcat gagttgctca ggggcaaggg ctgcaagtgg gctgtgctta ggagaaagtg     5700

acacctggca gtgagggaag atggtgagca ttattagcct ttgttgtcca gcatggcctt     5760

cttgtcctgt ctgctctgga gaggagcctg tgggaccagt cctgcctggg gagggcatac     5820

ccacacgtgc cagctgattc tgactctgaa tacatcatgt ccggacttgg gggtgtttct     5880

gcagaaaaag gaggttgttt ttcagccttg aacatcttca ggaggataga gactcttgct     5940

cacatattct tagcaaaggg aagggtctct catctccagg ccacagagat agttcttcca     6000

ttgccctaag aggctaggct aaccctcttg acataactta gacagcaaag cacttcatcc     6060

tgtagttggg ctctgtcacc tttctcttca gttggccaca ttctcgtttc ctccatcctg     6120

ctatgctttg tgtgctcggg ctgtgtgtgg ggtttttccc tggtggaagg aagcccagct     6180

gtgtattgaa tgtccttcat gtgttgtgtg tggctcagaa agcctgtcac ttggcccctg     6240

tgctctgagc cgtgagggtg gggaggtggc tgttccatta aagtgggagt attggatggc     6300

cctcttgaaa ctagaatttt gcctttttta gtatgcagta taaagtttcc agcatctatt     6360

ggtaacacaa agatttgctg gtttttaaaa taatacagta agcataagta tgtaagtttt     6420

tagaattggt actagaagtt ggacagctag ttattctcga gaactttatt tcactagaaa     6480

aatatactaa ttggaaagca gtttccagga gttaactcag tttaattttc agtctcagtt     6540

attttagcct gttgagtttt tgatggcaca cctttggaga gatggccacg cctgattccc     6600

atttcagggg catcagacca taccttttta agaagctccg tgaatctagt catctaccct     6660

tcatcctggg cgaacagcca aaaagagaag gggacaaggt gtctttttct ccttctcact     6720

ggggtgacat gaattctttt agttaatggc tgtttgcaaa ttctaaacta atgaaatact     6780

tagcagctaa catgttcaat ctagtaatga tgagtttaaa tctcaattga cagtaatgtt     6840

ttagataaac aggcccagta attcagttga tgaactgtat atcttctcag tctagatttg     6900

taaatgttta atgaattcag ggttataagc atagttcttt aagtaagatt ccagatagtt     6960

gatttgcaac cagcagtcta cctatgaatg tatcccaaac ctttagaaga ttggaaaaga     7020

tttttgaaat aatgatttag ttttgtagga aaaacacccc cttgaaaatt aattcggttg     7080

acccagtaac attttttaaa acaattggtg gctccaaaag gcctgccaac aaagaaaagt     7140

ccaaattatc tagtgggaca ttttgaatgt tttatgttta ttttgggtcc actgtaaact     7200

ttggttcaaa aaagaatttg aatttaaaga atttaccatt atttaaatta ttaccaagtt     7260

tttacatttt catgatggta ttttccaggt atgaatgaaa catgactttt tgattgtggt     7320

acttcctgta tcccctgtag tgccaaaacc agtgatactt tatttgctcc tatggcagct     7380

catagaggta accgaagtga tttttcctca gtaattgaaa cacatattct ctaaatgcca     7440

atgtgtggtg atgggccctg cactgccttc atttctctag ggcagtgtct ttggattgtc     7500

tagggcctag gtaattctga gaactactgt aaaccaacca cagggcacta aagcaatgta     7560

cacaccactc tttgtgtgta tggaaggggt tatataaacc tgggctatgc tggacatcta     7620

cagaagagta ttacattcac ttgcaaagtt tacatttttg agctcacagt tatgaaaaat     7680

atgacccaca agtttttcag gcaggtgagg atgggtcttc ttgcaaatgc atgagttctg     7740

tcttgagtcc tgggaacttc tctgttggtt gagtgtgggc tcattccctg actctcctaa     7800

tcatgtttgc gtcagaatgt tagcattgta aataaaagaa taggttgtat aatagataca     7860

caacacttga aactttactt taaaaaaatc gatagttcta catatatatt tagttatatc     7920

acttgacaga tttcttctac acagtgtgga gattgtttta taccacagat tatttttata     7980

aagttagtga atttgaatga ttttgtaatc agagctaatg agctttacct ttcaagagaa     8040

acgtacactg gagcatgagt ggtgtggaac ttttacttag tgtttatatg gattcttgtg     8100

atacactggc agactggagt caatttgcgg gtcttttttg gccaaaactc cacttgtggt     8160

tgtgtaggac agtgatattc agctcagctt cttgtggatt gggaggagag agggcctgca     8220

atgtgtttta cattggtgct tcctcctgag atttctgttg aacaaagggt tctgaggtca     8280

aaaattagtt tgtaagcctt tgccatagga catagtcatg tgagagtgtt tgggggaaca     8340

gaaattgtat aggggtgcct attggggtgg gatgggactc gaataagatt caggtacaaa     8400

aactttgaaa tgagaatctg gtggtttgag taatccacca gactgaatta tctaagatca     8460

cattatccag gttggggggc agaattaccc agttaagtaa ttgttcagaa aagtggggag     8520

ggtggcatgt ggatgcagtg atccaattaa atggagagct gccaggcaca ttttgtcctc     8580

tctggtcagt gagaatggtt gggttggctc gctgcttcaa tctgtggaat cagccaggag     8640

cccagtgagg aagctcagaa ccccagtaac agcagagcat ctttcagata gctccagagt     8700

tttcctgctt ttctgaggaa gctcagcatc actgccacaa tacggaaagt ggtcttcatt     8760

ttagcctatt tatttttagg cagagagtgg atggttattt gtgtgggact tttggtggcg     8820

atatataatg aataattaag ttaatttctg gtatgcataa tggccagtcc tgaggcccag     8880

ctgaagacct gtcccccaga ccctgcccgc tggcttcagg ctgctgcttc tagacagagg     8940

tgcactggac gggatagttt tatcaagaga atccctaatg tgtcatttta aaccagctgt     9000

gctttttatt cattctggtt gagcgtatag gtttacactt tacccttttt atacttggaa     9060

taaatttagt tccagcagat ctagtagcac tccagaaacc aaccccatct gttccccata     9120

aaaagaacat tttctctgct ctccagccac gtgtcttgga atgtaattct gttgtgcctt     9180

tgtttttatc actctcttcg ccccaaaagc aactgctgta agcttttttc tacttgtctt     9240

ttctagtccc caacctctac ctttttcctt tttcccagcc ctaatttctg gatgcacttc     9300

tgtgatccag gtattttaag aaccagttac ctcagacctc atgttgaaca gtgtcgccat     9360

ctgggtcctc ttgatactgc agacttttaa cgtacacatg caggaaccct gctgagcgtg     9420

ggcacttgtt ttaaagcaaa actcttccca aggactgaag aaagggcttc tggcaagctc     9480

gtcatggcat tgtggtggga tgggtctaga gtgtcatctg aatggtgctt cctgtgttcc     9540

tctttgaatt ctgccatttt cagtattctt gtgtgtctga ataggcaaag cgatttaatt     9600

ggctggtctt gcacgcaaat tagttccaaa gataagctct ttgtaacaca tttccagtcg     9660

ctaatgctca aatgtagaac attcctttaa atggcaggat aaaaaaccca ctatccacca     9720

tagtgcattt tgggaagatg tctgtagcat atgttgctgt gaaattaggc cttgtgggat     9780

atggctgttt gtcattttga tgtattttaa ataaatatat atatttttta aagagccttt     9840

tttaccagtt caaaaagttt aattaaccag cagtcaccgc atctgaattt ttgtctctgg     9900

ggcatagatg gcagaccaag attaaaagtg gtaactcagc tatacgagca tgggctacct     9960

tcctgggctc tcctgcagtc ctgtagacct gctgttccgc agaccatggg acacaaggtc    10020

agtgtgttcc cagtgagggt cccaagtcag tcatcttaag tgtttgttct ctgccccatt    10080

cagtggactg ttgacttcag tccctgcaag tgctttagcc cgagtggggt tttctcagag    10140

cactgccacg agttaagtgt gtgtttagcc aaataatttc tccgtaaggg aaaaatgcag    10200

tcacccaaat tttaccaaca atgacagaga tgagagtaga aaagattagg caacatctga    10260

gttttaactt gaaaagtgtc caagtcatca tgaaaggccg actgggagca agtgattatt    10320

agagattctt caggagacct catctgaaaa tgttaagact gccagtgagg gaaggaattg    10380

ttaaaatgcc agcggctttt ttttcctctt tttttctgta attctgtaaa aatgcagaga    10440

aagttgagtg gtacttcaga attgagggag agggttaccg cagagtagaa atatatttct    10500

agatttcagt tccacaccac aaatccacaa caatgccatt tttcaactgt acaaaaatct    10560

gcttatgaac tggacatgat cttaatggta gtgtcaaagg ccaagttttt cacctgttaa    10620

tatttttcca catttgtcct tgaatctgaa taactttata cagtactgta aatttaactt    10680

acatcgagtt tgttgtcaat tcttatgaaa agagctttct gcatgtaaca catacggtta    10740

aagaacacag caaaggacaa aatttgcagg aacagttttg gaaccaacag aaaatgtcac    10800

cttttatttg ccatcttata tatatctatc agttttacca gctacttcta aatttgtaca    10860

ttatttgtaa gggaaagaag gaaaacccta agacttgtct aacttagtgg agaatgtgtg    10920

tgttgggctt aggatggata gctaagtctt attgagctgt gttacctaac ttgtatataa    10980

aaattgtaat taaaagtttg ggttcacctg tttctcacag tttaaaatga tgagtaattg    11040

caaactctgg aaatgtgact agtatatgat ttaaggctgt agaagcaagg aagctctttc    11100

aagtgctaaa actaaagact tctagttttt ggctcaaata agtactgttt gtataccagg    11160

atatgtgaga tgtaaatgta gtaggtcact tttcaccctt gtagctataa aataaaaatt    11220

ttgtagaaca gaaatagctt gtactactga attaacaaaa gttatactaa agtatcatgt    11280

ttaaaaaaaa tatatatata tatacagagt taagcttgtt gctgttaccc tgtctggatt    11340

tgaaaagtgt gctgatttat atatatatat tacacacaca cacacacaca cacacacaca    11400

cacacacaca cacacacaca cacacacaca cacacacaca cacatacacc taaaatggcc    11460

taaagcagac atccatgtaa ttacagttgc aaaatgaaaa cattttggaa agaacattgt    11520

atcatagttc attcatttgc agtggatctt tgttcctttt tactgtggta attttagaaa    11580

tgagtgtcaa gtttgaaatt agatctgcta agttggggtt ttgctgcttg aactctgcac    11640

tgggtcctca aataaaccga tgtgaatgta gttttttccc cctgtgtgaa gaagcagtta    11700

caccccaaca ataggaggaa aaatctagaa ctatttcaag ttttatcttt ttgtatatga    11760

aaataaaata ataataaaac aa                                             11782


<210>  8
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 
1               5                   10                  15      


Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr 
            20                  25                  30          


Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg 
        35                  40                  45              


Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg 
    50                  55                  60                  


Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 
65                  70                  75                  80  


Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn 
                85                  90                  95      


Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 
            100                 105                 110         


Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro 
        115                 120                 125             


Pro Pro Thr Ala Pro Thr Leu Leu Thr Val Leu Ala Tyr Ser Leu Leu 
    130                 135                 140                 


Pro Ile Gly Gly Leu Ser Leu Ile Val Leu Leu Ala Phe Trp Met Tyr 
145                 150                 155                 160 


Arg His Arg Lys Pro Pro Tyr Gly His Val Asp Ile His Glu Asp Pro 
                165                 170                 175     


Gly Pro Pro Pro Pro Ser Pro Leu Val Gly Leu Lys Pro Leu Gln Leu 
            180                 185                 190         


Leu Glu Ile Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys Ala Gln 
        195                 200                 205             


Leu Met Asn Asp Phe Val Ala Val Lys Ile Phe Pro Leu Gln Asp Lys 
    210                 215                 220                 


Gln Ser Trp Gln Ser Glu Arg Glu Ile Phe Ser Thr Pro Gly Met Lys 
225                 230                 235                 240 


His Glu Asn Leu Leu Gln Phe Ile Ala Ala Glu Lys Arg Gly Ser Asn 
                245                 250                 255     


Leu Glu Val Glu Leu Trp Leu Ile Thr Ala Phe His Asp Lys Gly Ser 
            260                 265                 270         


Leu Thr Asp Tyr Leu Lys Gly Asn Ile Ile Thr Trp Asn Glu Leu Cys 
        275                 280                 285             


His Val Ala Glu Thr Met Ser Arg Gly Leu Ser Tyr Leu His Glu Asp 
    290                 295                 300                 


Val Pro Trp Cys Arg Gly Glu Gly His Lys Pro Ser Ile Ala His Arg 
305                 310                 315                 320 


Asp Phe Lys Ser Lys Asn Val Leu Leu Lys Ser Asp Leu Thr Ala Val 
                325                 330                 335     


Leu Ala Asp Phe Gly Leu Ala Val Arg Phe Glu Pro Gly Lys Pro Pro 
            340                 345                 350         


Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro Glu 
        355                 360                 365             


Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg Ile 
    370                 375                 380                 


Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Val Ser Arg Cys 
385                 390                 395                 400 


Lys Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu Glu 
                405                 410                 415     


Glu Ile Gly Gln His Pro Ser Leu Glu Glu Leu Gln Glu Val Val Val 
            420                 425                 430         


His Lys Lys Met Arg Pro Thr Ile Lys Asp His Trp Leu Lys His Pro 
        435                 440                 445             


Gly Leu Ala Gln Leu Cys Val Thr Ile Glu Glu Cys Trp Asp His Asp 
    450                 455                 460                 


Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Glu Glu Arg Val Ser Leu 
465                 470                 475                 480 


Ile Arg Arg Ser Val Asn Gly Thr Thr Ser Asp Cys Leu Val Ser Leu 
                485                 490                 495     


Val Thr Ser Val Thr Asn Val Asp Leu Pro Pro Lys Glu Ser Ser Ile 
            500                 505                 510         


<210>  9
<211>  4704
<212>  DNA
<213>  Homo sapiens

<400>  9
ggagagggag aaggctctcg ggcggagaga ggtcctgccc agctgttggc gaggagtttc       60

ctgtttcccc cgcagcgctg agttgaagtt gagtgagtca ctcgcgcgca cggagcgacg      120

acacccccgc gcgtgcaccc gctcgggaca ggagccggac tcctgtgcag cttccctcgg      180

ccgccggggg cctccccgcg cctcgccggc ctccaggccc cctcctggct ggcgagcggg      240

cgccacatct ggcccgcaca tctgcgctgc cggcccggcg cggggtccgg agagggcgcg      300

gcgcggaggc gcagccaggg gtccgggaag gcgccgtccg ctgcgctggg ggctcggtct      360

atgacgagca gcggggtctg ccatgggtcg ggggctgctc aggggcctgt ggccgctgca      420

catcgtcctg tggacgcgta tcgccagcac gatcccaccg cacgttcaga agtcggatgt      480

ggaaatggag gcccagaaag atgaaatcat ctgccccagc tgtaatagga ctgcccatcc      540

actgagacat attaataacg acatgatagt cactgacaac aacggtgcag tcaagtttcc      600

acaactgtgt aaattttgtg atgtgagatt ttccacctgt gacaaccaga aatcctgcat      660

gagcaactgc agcatcacct ccatctgtga gaagccacag gaagtctgtg tggctgtatg      720

gagaaagaat gacgagaaca taacactaga gacagtttgc catgacccca agctccccta      780

ccatgacttt attctggaag atgctgcttc tccaaagtgc attatgaagg aaaaaaaaaa      840

gcctggtgag actttcttca tgtgttcctg tagctctgat gagtgcaatg acaacatcat      900

cttctcagaa gaatataaca ccagcaatcc tgacttgttg ctagtcatat ttcaagtgac      960

aggcatcagc ctcctgccac cactgggagt tgccatatct gtcatcatca tcttctactg     1020

ctaccgcgtt aaccggcagc agaagctgag ttcaacctgg gaaaccggca agacgcggaa     1080

gctcatggag ttcagcgagc actgtgccat catcctggaa gatgaccgct ctgacatcag     1140

ctccacgtgt gccaacaaca tcaaccacaa cacagagctg ctgcccattg agctggacac     1200

cctggtgggg aaaggtcgct ttgctgaggt ctataaggcc aagctgaagc agaacacttc     1260

agagcagttt gagacagtgg cagtcaagat ctttccctat gaggagtatg cctcttggaa     1320

gacagagaag gacatcttct cagacatcaa tctgaagcat gagaacatac tccagttcct     1380

gacggctgag gagcggaaga cggagttggg gaaacaatac tggctgatca ccgccttcca     1440

cgccaagggc aacctacagg agtacctgac gcggcatgtc atcagctggg aggacctgcg     1500

caagctgggc agctccctcg cccgggggat tgctcacctc cacagtgatc acactccatg     1560

tgggaggccc aagatgccca tcgtgcacag ggacctcaag agctccaata tcctcgtgaa     1620

gaacgaccta acctgctgcc tgtgtgactt tgggctttcc ctgcgtctgg accctactct     1680

gtctgtggat gacctggcta acagtgggca ggtgggaact gcaagataca tggctccaga     1740

agtcctagaa tccaggatga atttggagaa tgttgagtcc ttcaagcaga ccgatgtcta     1800

ctccatggct ctggtgctct gggaaatgac atctcgctgt aatgcagtgg gagaagtaaa     1860

agattatgag cctccatttg gttccaaggt gcgggagcac ccctgtgtcg aaagcatgaa     1920

ggacaacgtg ttgagagatc gagggcgacc agaaattccc agcttctggc tcaaccacca     1980

gggcatccag atggtgtgtg agacgttgac tgagtgctgg gaccacgacc cagaggcccg     2040

tctcacagcc cagtgtgtgg cagaacgctt cagtgagctg gagcatctgg acaggctctc     2100

ggggaggagc tgctcggagg agaagattcc tgaagacggc tccctaaaca ctaccaaata     2160

gctcttctgg ggcaggctgg gccatgtcca aagaggctgc ccctctcacc aaagaacaga     2220

ggcagcagga agctgcccct gaactgatgc ttcctggaaa accaaggggg tcactcccct     2280

ccctgtaagc tgtggggata agcagaaaca acagcagcag ggagtgggtg acatagagca     2340

ttctatgcct ttgacattgt cataggataa gctgtgttag cacttcctca ggaaatgaga     2400

ttgattttta caatagccaa taacatttgc actttattaa tgcctgtata taaatatgaa     2460

tagctatgtt ttatatatat atatatatat ctatatatgt ctatagctct atatatatag     2520

ccataccttg aaaagagaca aggaaaaaca tcaaatattc ccaggaaatt ggttttattg     2580

gagaactcca gaaccaagca gagaaggaag ggacccatga cagcattagc atttgacaat     2640

cacacatgca gtggttctct gactgtaaaa cagtgaactt tgcatgagga aagaggctcc     2700

atgtctcaca gccagctatg accacattgc acttgctttt gcaaaataat cattccctgc     2760

ctagcacttc tcttctggcc atggaactaa gtacagtggc actgtttgag gaccagtgtt     2820

cccggggttc ctgtgtgccc ttatttctcc tggacttttc atttaagctc caagccccaa     2880

atctgggggg ctagtttaga aactctccct caacctagtt tagaaactct accccatctt     2940

taataccttg aatgttttga accccacttt ttaccttcat gggttgcaga aaaatcagaa     3000

cagatgtccc catccatgcg attgccccac catctactaa tgaaaaattg ttcttttttt     3060

catctttccc ctgcacttat gttactattc tctgctccca gccttcatcc ttttctaaaa     3120

aggagcaaat tctcactcta ggctttatcg tgtttacttt ttcattacac ttgacttgat     3180

tttctagttt tctatacaaa caccaatggg ttccatcttt ctgggctcct gattgctcaa     3240

gcacagtttg gcctgatgaa gaggatttca actacacaat actatcattg tcaggactat     3300

gacctcaggc actctaaaca tatgttttgt ttggtcagca cagcgtttca aaaagtgaag     3360

ccactttata aatatttgga gattttgcag gaaaatctgg atccccaggt aaggatagca     3420

gatggttttc agttatctcc agtccacgtt cacaaaatgt gaaggtgtgg agacacttac     3480

aaagctgcct cacttctcac tgtaaacatt agctctttcc actgcctacc tggaccccag     3540

tctaggaatt aaatctgcac ctaaccaagg tcccttgtaa gaaatgtcca ttcaagcagt     3600

cattctctgg gtatataata tgattttgac taccttatct ggtgttaaga tttgaagttg     3660

gccttttatt ggactaaagg ggaactcctt taagggtctc agttagccca agtttctttt     3720

gcttatatgt taatagtttt accctctgca ttggagagag gagtgcttta ctccaagaag     3780

ctttcctcat ggttaccgtt ctctccatca tgccagcctt ctcaaccttt gcagaaatta     3840

ctagagagga tttgaatgtg ggacacaaag gtcccatttg cagttagaaa atttgtgtcc     3900

acaaggacaa gaacaaagta tgagctttaa aactccatag gaaacttgtt aatcaacaaa     3960

gaagtgttaa tgctgcaagt aatctctttt ttaaaacttt ttgaagctac ttattttcag     4020

ccaaatagga atattagaga gggactggta gtgagaatat cagctctgtt tggatggtgg     4080

aaggtctcat tttattgaga tttttaagat acatgcaaag gtttggaaat agaacctcta     4140

ggcaccctcc tcagtgtggg tgggctgaga gttaaagaca gtgtggctgc agtagcatag     4200

aggcgcctag aaattccact tgcaccgtag ggcatgctga taccatccca atagctgttg     4260

cccattgacc tctagtggtg agtttctaga atactggtcc attcatgaga tattcaagat     4320

tcaagagtat tctcacttct gggttatcag cataaactgg aatgtagtgt cagaggatac     4380

tgtggcttgt tttgtttatg tttttttttc ttattcaaga aaaaagacca aggaataaca     4440

ttctgtagtt cctaaaaata ctgacttttt tcactactat acataaaggg aaagttttat     4500

tcttttatgg aacacttcag ctgtactcat gtattaaaat aggaatgtga atgctatata     4560

ctctttttat atcaaaagtc tcaagcactt atttttattc tatgcattgt ttgtctttta     4620

cataaataaa atgtttatta gattgaataa agcaaaatac tcaggtgagc atcctgcctc     4680

ctgttcccat tcctagtagc taaa                                            4704


<210>  10
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


