                         SEQUENCE LISTING

<110>  Yumanity Therapeutics, Inc.
 
<120>  METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS

<130>  51549-021WO2

<150>  US 63/113,157
<151>  2020-11-12

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1
auucugauau uccggaaau                                                    19


<210>  2
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2
augaguaagu ugacgaugu                                                    19


<210>  3
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3
gauguaaacu ccuucguga                                                    19


<210>  4
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4
caaccugaac agcaguuaa                                                    19


<210>  5
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5
gguuauagag ucuaucauu                                                    19


<210>  6
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6
gucacaagau gaucgacuu                                                    19


<210>  7
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
gccaagaaga agugacgcu                                                    19


<210>  8
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
ggcauauagu agcugcuua                                                    19


<210>  9
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
caccuugugu gcugggaau                                                    19


<210>  10
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
ggccugcucu guucaccu                                                     18


<210>  11
<211>  4309
<212>  DNA
<213>  Homo sapiens

<400>  11
gccttctctg ctcgcgcctg gcgcccggag cctgcccggg acctccgccg gagccgcgct       60

cgctgcaggc ggcctcgagc gctctctcgt tgatgccgtt ttggaggtga ccggcgcggc      120

ggccgctcta tggtggggcc gcgttagtgg ctgcggctcc gcgggactcc agggcgcggc      180

tgcgaggtgg cggggcgccc cgcctgcaga accctgcttg cagctcaggt ttcggggtgc      240

ttgaggaggc cgccacggca gcgcgggagc ggaagatgtt ggagctgagg caccggggaa      300

gctgccccgg ccccagggaa gcggtgtcgc cgccacaccg cgagggagag gcggccggcg      360

gcgaccacga aaccgagagc accagcgaca aagaaacaga tattgatgac agatatggag      420

atttggattc cagaacagat tctgatattc cggaaattcc accatcctca gatagaaccc      480

ctgagattct caaaaaagct ctatctggtt tatcttcaag gtggaaaaac tggtggatac      540

gtggaattct cactctaact atgatctcgt tgtttttcct gatcatctat atgggatcct      600

tcatgctgat gcttcttgtt ctgggcatcc aagtgaaatg cttccatgaa attatcacta      660

taggttatag agtctatcat tcttatgatc taccatggtt tagaacacta agttggtact      720

ttctattgtg tgtaaactac tttttctatg gagagactgt agctgattat tttgctacat      780

ttgttcaaag agaagaacaa cttcagttcc tcattcgcta ccatagattt atatcatttg      840

ccctctatct ggcaggtttc tgcatgtttg tactgagttt ggtgaagaaa cattatcgtc      900

tgcagtttta tatgttcgca tggactcatg tcactttact gataactgtc actcagtcac      960

accttgtcat ccaaaatctg tttgaaggca tgatatggtt ccttgttcca atatcaagtg     1020

ttatctgcaa tgacataact gcttaccttt ttggattttt ttttgggaga actccattaa     1080

ttaagttgtc tcctaaaaag acttgggaag gattcattgg tggtttcttt tccacagttg     1140

tgtttggatt cattgctgcc tatgtgttat ccaaatacca gtactttgtc tgcccagtgg     1200

aataccgaag tgatgtaaac tccttcgtga cagaatgtga gccctcagaa cttttccagc     1260

ttcagactta ctcacttcca ccctttctaa aggcagtctt gagacaggaa agagtgagct     1320

tgtacccttt ccagatccac agcattgcac tgtcaacctt tgcatcttta attggcccat     1380

ttggaggctt ctttgctagt ggattcaaaa gagccttcaa aatcaaggat tttgcaaata     1440

ccattcctgg acatggtggg ataatggaca gatttgattg tcagtatttg atggcaactt     1500

ttgtacatgt gtacatcaca agttttataa ggggcccaaa tcccagcaaa gtgctacagc     1560

agttgttggt gcttcaacct gaacagcagt taaatatata taaaaccctg aagactcatc     1620

tcattgagaa aggaatccta caacccacct tgaaggtata actggatcca gagagggaag     1680

gactgacaag aaggaattat tcagaaaaac actgacagat gttttataaa ttgtacagaa     1740

aaatagttaa aaatgcaata ggttgaagtt ttggagatat gtttctctct gaaattactg     1800

tgaatattta acaaacactt acttgatcta tgttatgaaa taagtagcaa attgccagca     1860

aaatgtcttg taccttttct aaagtgtatt ttctgatgtg aacttccttc cccttacttg     1920

ctaggtttca taatttaaaa gactggtatt taaaagagtc aaacactata aaatgagtaa     1980

gttgacgatg ttttaagatt gcacctggca gtgtgccttt ttgcacaaat atttactttt     2040

gcacttggag ctgcttttaa ttttagcaaa atgttttatg caaggcacaa taggaagtca     2100

gttctcctgc acttcctcct catgtagtct ggagtacttt ctaaagggct tagttggatt     2160

taaaaaaaaa aaaaaaagat tgtctacttt tcaaagaagt aaccatttgc caggggaaaa     2220

cattctgctt ttaggtagtt tcaaaattca ggggagggag cctgaaattt ttgccatgat     2280

tggtttgtta gaaagagcag gcatcagact acttctgata aaattgtttg gaaggtcacg     2340

acctcgcaaa aacttttcaa gagcaacaag gaagaattct gctgtgaaga acacagtgta     2400

cggatcctcc gcatattatc tcaacagagg acagtagctc aggaggcagc ttcaaacggt     2460

gacctgtggc ctgggccatc tcttcgtcat gtgcttcact tttccctgtt tccctgtgaa     2520

ctggcttcca tggttctgta gggtagtgag tcggggttgt ggctgcagca gagcaggaga     2580

tgcttgcccg agtgggagca acccaccccc gtgtccccaa tgcctcactc ctggcttcta     2640

gtgcagccct ttgtagactc acctcgcaag aaggaagatc tgcctggaga cctgatccca     2700

gtccagcttt ttgaccatag gtcatctttg tccccttgct cctttgcatc atgtcataaa     2760

atttgaggat atcagctgat tattttttct tccaagaatg aaaatcaagc agaattgatt     2820

cctacacgaa aaaaaagcac acgaatgcca aacctttcct ttggtggact ggacactaac     2880

cagatgagag taaatttctt atccgtggac gtatgtaagc tactgctgct gtgtgctctc     2940

cacagccata tttattgtat taaacaatca gcactaaacc ttcaaaaatt gcccagtgtt     3000

cctagttaaa tgttcagagg ggagaaatag atatatttta aataatgttt tgctaatgaa     3060

aagagtaaat atttttgttt aaatcagcaa aaactttcca ttattttata tttccgtcta     3120

ctatacctaa aacaaaagat tgccgttata cctgggttcc actgatgcag tcagccagca     3180

cctcctcaca tgcacacatg attagacata ggtgcactcg gtaccaagag tccattttat     3240

ggtccagcat atactccatt gattcatcat cactgcatgt gttcagccag tgtatctcac     3300

actatccata caaatctaaa attgatactg gaaatgttat tataggaggc agtgatcgca     3360

tttaaaatca ggccacctac aagtttaatt ttcaacatct catgttttta tttgtcccat     3420

tacagcctca aatgttggtc ataaaaaaaa tttaggctac caaagtttaa agaataaaat     3480

gaaaatttta taagaactta cattaaaaac tcagtagttt gcatgagtaa gaactccttg     3540

agatacacag atccccccac atttgtattt aaaataattg gtgaggcatt gaaatccaga     3600

attataagaa agcattactg aatatgtgtg ttataaaatc aatattatta taaacaaaat     3660

aggaagctag aaatatttgg gatcacagta atagcttttc tcaaatatac ttttagaatt     3720

gaatgtacat tatcctatat gtaaaaaagc aaattattaa ttttaatgga gctctcgatt     3780

gaccttttta gcatactttt atagcatgta tattaaaata gaatatattt tagcaaaaga     3840

ttgccataaa accctgactt ggctcatttt gatatttgca ctgtgaagag ggcttaaatt     3900

ccaatgtagc aatgtggtgg cagacaaatg aaaaactagg aagttctttc acagtaatgc     3960

ctagttgttc caaatttgct atatttggag gtgctctact ggtacttcct gcttgactct     4020

ctgacctgtg ggatgcacat tcttcctcag cgctttttcc ttgttgtggt gacgtacatt     4080

cactatctga gagtgaaaga ccacacacac ccctcttttt aaaattattg tatctcttcc     4140

ttttcacttt ggtttgaaca aagatagtgt caccttgttc cgtgaaaaag aaaaagcata     4200

aacagtgtat atttagggta tatgggtgat agcttatgat gtgtgtcaat cagttctctg     4260

aatcttttac tgaaactgag acaggaaaat aaaactgaaa caaatcata                 4309


<210>  12
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Leu Glu Leu Arg His Arg Gly Ser Cys Pro Gly Pro Arg Glu Ala 
1               5                   10                  15      


Val Ser Pro Pro His Arg Glu Gly Glu Ala Ala Gly Gly Asp His Glu 
            20                  25                  30          


Thr Glu Ser Thr Ser Asp Lys Glu Thr Asp Ile Asp Asp Arg Tyr Gly 
        35                  40                  45              


Asp Leu Asp Ser Arg Thr Asp Ser Asp Ile Pro Glu Ile Pro Pro Ser 
    50                  55                  60                  


Ser Asp Arg Thr Pro Glu Ile Leu Lys Lys Ala Leu Ser Gly Leu Ser 
65                  70                  75                  80  


Ser Arg Trp Lys Asn Trp Trp Ile Arg Gly Ile Leu Thr Leu Thr Met 
                85                  90                  95      


Ile Ser Leu Phe Phe Leu Ile Ile Tyr Met Gly Ser Phe Met Leu Met 
            100                 105                 110         


Leu Leu Val Leu Gly Ile Gln Val Lys Cys Phe His Glu Ile Ile Thr 
        115                 120                 125             


Ile Gly Tyr Arg Val Tyr His Ser Tyr Asp Leu Pro Trp Phe Arg Thr 
    130                 135                 140                 


Leu Ser Trp Tyr Phe Leu Leu Cys Val Asn Tyr Phe Phe Tyr Gly Glu 
145                 150                 155                 160 


Thr Val Ala Asp Tyr Phe Ala Thr Phe Val Gln Arg Glu Glu Gln Leu 
                165                 170                 175     


Gln Phe Leu Ile Arg Tyr His Arg Phe Ile Ser Phe Ala Leu Tyr Leu 
            180                 185                 190         


Ala Gly Phe Cys Met Phe Val Leu Ser Leu Val Lys Lys His Tyr Arg 
        195                 200                 205             


Leu Gln Phe Tyr Met Phe Ala Trp Thr His Val Thr Leu Leu Ile Thr 
    210                 215                 220                 


Val Thr Gln Ser His Leu Val Ile Gln Asn Leu Phe Glu Gly Met Ile 
225                 230                 235                 240 


Trp Phe Leu Val Pro Ile Ser Ser Val Ile Cys Asn Asp Ile Thr Ala 
                245                 250                 255     


Tyr Leu Phe Gly Phe Phe Phe Gly Arg Thr Pro Leu Ile Lys Leu Ser 
            260                 265                 270         


Pro Lys Lys Thr Trp Glu Gly Phe Ile Gly Gly Phe Phe Ser Thr Val 
        275                 280                 285             


Val Phe Gly Phe Ile Ala Ala Tyr Val Leu Ser Lys Tyr Gln Tyr Phe 
    290                 295                 300                 


Val Cys Pro Val Glu Tyr Arg Ser Asp Val Asn Ser Phe Val Thr Glu 
305                 310                 315                 320 


Cys Glu Pro Ser Glu Leu Phe Gln Leu Gln Thr Tyr Ser Leu Pro Pro 
                325                 330                 335     


Phe Leu Lys Ala Val Leu Arg Gln Glu Arg Val Ser Leu Tyr Pro Phe 
            340                 345                 350         


Gln Ile His Ser Ile Ala Leu Ser Thr Phe Ala Ser Leu Ile Gly Pro 
        355                 360                 365             


Phe Gly Gly Phe Phe Ala Ser Gly Phe Lys Arg Ala Phe Lys Ile Lys 
    370                 375                 380                 


Asp Phe Ala Asn Thr Ile Pro Gly His Gly Gly Ile Met Asp Arg Phe 
385                 390                 395                 400 


Asp Cys Gln Tyr Leu Met Ala Thr Phe Val His Val Tyr Ile Thr Ser 
                405                 410                 415     


Phe Ile Arg Gly Pro Asn Pro Ser Lys Val Leu Gln Gln Leu Leu Val 
            420                 425                 430         


Leu Gln Pro Glu Gln Gln Leu Asn Ile Tyr Lys Thr Leu Lys Thr His 
        435                 440                 445             


Leu Ile Glu Lys Gly Ile Leu Gln Pro Thr Leu Lys Val 
    450                 455                 460     


<210>  13
<211>  1708
<212>  DNA
<213>  Homo sapiens

<400>  13
aagccacttt ttcctctctc caattttgca acgacgggcg cggaggagga ggttcccgga       60

agccacgcgc agctggagca gcggcgaccg cagctggagg cccggagcgc ctgcggggct      120

ggcagaggcg agggaggttg cgggtaggaa gggcggactg cgcgcgcccc ctgcgtcccg      180

cgcacctcgg ggccggtcca tgctcccgac ggctgcgggc ttcagcatct ggggccaggt      240

tggggcggcg gggtccaggg cgcaggtggt gcggccgatg cgccgggccg gaggctgagg      300

ccgcgctgcg gggctgggac agcactggca tctccagagc aggcccgggg cagcaaggga      360

ggcgccgcga tgccagacga aaatatcttc ctgttcgtgc ccaacctcat cggaacccgg      420

tttggggcca tgctggacat gctgacggac cgctgctcca ccatgtgcct gttggtcaac      480

ctggccctgc tgtaccctgg agccacgctg ttcttccaaa tcagcatgag tttggatgtg      540

gccagtcact ggctgcacct ccacagttct gtggtccgag gcagtgagag tcacaagatg      600

atcgacttgt ccgggaatcc ggtgcttcgg atctactaca cctcgaggcc tgctctgttc      660

accttgtgtg ctgggaatga gctcttctac tgcctcctct acctgttcca tttctctgag      720

ggacctttag ttggctctgt gggactgttc cggatgggcc tctgggtcac tgcccccatc      780

gccttgctga agtcgctcat cagcgtcatc cacctgatca cggccgcccg caacatggct      840

gccctggacg cagcagaccg cgccaagaag aagtgacgct ggagccccgg gtcctggctg      900

cccacctgcc ctgggagtct tgctgtgcca cacagctccc caccccctgc taggaggtcc      960

cagtctcacg ccttcctcat gtgttgttct acctgctggg atgggggtca gcctctcttt     1020

ggtgacgtca cgttctctgg gatcctgagg acccgggcct caaatcaggg aggatacgcg     1080

ggaggccccc tccatccagg cggtgctcct ggggtgccgg gaccgggcag tgtcacaccc     1140

tgcctgctca gtcctggggt ccgagatgct agggacgctt gagtgaggga ggtggtgtga     1200

gggccaggtt tcctgaaagg cgggagtcag acctccgccc ccagccagag caagcttggg     1260

gcaccatgcc caggagggaa gaagccatcc acagccttcc ctgtcaccgg ctcctctgtc     1320

ctgcctaccc tggtcctggc gggacttcac tatttgactt ggtttccttt cagatattct     1380

tggctcaggg cctgggttga gggagcttag ggaaggacgt ccgtctgggt gcttttcctc     1440

cagtttgctg gctggcttct ccgtctaccc acagtgacct cacagagagg ccctcctgcc     1500

acccatgctc atgtggtgtc cccaccgccc acttgtttga tgtcactgac tgtctacatg     1560

tatttatatt cttgatattt tctaccctca ctagaatgta aactccatga aggcacagac     1620

ttttcttgtt ctcttctcta tccctagagt aagaccaact tgaacctggc atatagtagc     1680

tgcttaataa atactcgtct gtcaatga                                        1708


<210>  14
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Pro Asp Glu Asn Ile Phe Leu Phe Val Pro Asn Leu Ile Gly Thr 
1               5                   10                  15      


Arg Phe Gly Ala Met Leu Asp Met Leu Thr Asp Arg Cys Ser Thr Met 
            20                  25                  30          


Cys Leu Leu Val Asn Leu Ala Leu Leu Tyr Pro Gly Ala Thr Leu Phe 
        35                  40                  45              


Phe Gln Ile Ser Met Ser Leu Asp Val Ala Ser His Trp Leu His Leu 
    50                  55                  60                  


His Ser Ser Val Val Arg Gly Ser Glu Ser His Lys Met Ile Asp Leu 
65                  70                  75                  80  


Ser Gly Asn Pro Val Leu Arg Ile Tyr Tyr Thr Ser Arg Pro Ala Leu 
                85                  90                  95      


Phe Thr Leu Cys Ala Gly Asn Glu Leu Phe Tyr Cys Leu Leu Tyr Leu 
            100                 105                 110         


Phe His Phe Ser Glu Gly Pro Leu Val Gly Ser Val Gly Leu Phe Arg 
        115                 120                 125             


Met Gly Leu Trp Val Thr Ala Pro Ile Ala Leu Leu Lys Ser Leu Ile 
    130                 135                 140                 


Ser Val Ile His Leu Ile Thr Ala Ala Arg Asn Met Ala Ala Leu Asp 
145                 150                 155                 160 


Ala Ala Asp Arg Ala Lys Lys Lys 
                165             


<210>  15
<211>  2727
<212>  DNA
<213>  Homo sapiens

<400>  15
agttcctgcc agtgagtccc taggcctcca tctctctccc ttgctgtacc accttcacca       60

ccatccatgc gaccccaaga gccttaatga ctctagaaga gactccaggc aggggaagct      120

gaaaggacct ttcactccct acttttggcc agggccttct gtgccacctg ccaagaccag      180

caggcctacc ctctgaagag gtccaagcaa cggaagtact actacgaagc tgcctttctg      240

gccatccttg agaaaaatag acagatggcc aaggagaggg gcctaataag ccccagtgat      300

tttgcccagc tgcaaaaata catggaatac tccaccaaaa aggtcagtga tgtcctaaag      360

ctcttcgagg atggcgagat ggctaaatat gtccaaggag atgccattgg gtacgaggga      420

ttccagcaat tcctgaaaat ctatctcgaa gtggataatg ttcccagaca cctaagcctg      480

gcactgtttc aatcctttga gactggtcac tgcttaaatg agacaaatgt gacaaaagat      540

gtggtgtgtc tcaatgatgt ttcctgctac ttttcccttc tggagggtgg tcggccagaa      600

gacaagttag aattcacctt caagctgtac gacacggaca gaaatgggat cctggacagc      660

tcagaagtgg acaaaattat cctacagatg atgcgagtgg ctgaatacct ggattgggat      720

gtgtctgagc tgaggccgat tcttcaggag atgatgaaag agattgacta tgatggcagt      780

ggctctgtct ctcaagctga gtgggtccgg gctggggcca ccaccgtgcc actgctagtg      840

ctgctgggtc tggagatgac tctgaaggac gacggacagc acatgtggag gcccaagagg      900

ttccccagac cagtctactg caatctgtgc gagtcaagca ttggtcttgg caaacaggga      960

ctgagctgta acctctgtaa gtacactgtt cacgaccagt gtgccatgaa agccctgcct     1020

tgtgaagtca gcacctatgc caagtctcgg aaggacattg gtgtccaatc acatgtgtgg     1080

gtgcgaggag gctgtgagtc cgggcgctgc gaccgctgtc agaaaaagat ccggatctac     1140

cacagtctga ccgggctgca ttgtgtatgg tgccacctag agatccacga tgactgcctg     1200

caagcggtgg gccatgagtg tgactgtggg ctgctccggg atcacatcct gcctccatct     1260

tccatctatc ccagtgtcct ggcctctgga ccggatcgta aaaatagcaa aacaagccag     1320

aagaccatgg atgatttaaa tttgagcacc tctgaggctc tgcggattga ccctgttcct     1380

aacacccacc cacttctcgt ctttgtcaat cctaagagtg gcgggaagca ggggcaaagg     1440

gtgctctgga agttccagta tatattaaac cctcgacagg tgttcaacct cctaaaggat     1500

ggtcctgaga tagggctccg attattcaag gatgttcctg atagccggat tttggtgtgt     1560

ggtggagacg gcacagtagg ctggattcta gagaccattg acaaagctaa cttgccagtt     1620

ttgcctcctg ttgctgtgtt gcccctgggt actggaaatg atctggctcg atgcctaaga     1680

tggggaggag gttatgaagg acagaatctg gcaaagatcc tcaaggattt agagatgagt     1740

aaagtggtac atatggatcg atggtctgtg gaggtgatac ctcaacaaac tgaagaaaaa     1800

agtgacccag tcccctttca aatcatcaat aactacttct ctattggcgt ggatgcctct     1860

attgctcatc gattccacat catgcgagag aaatatccgg agaagttcaa cagcagaatg     1920

aagaacaagc tatggtactt cgaatttgcc acatctgaat ccatcttctc aacatgcaaa     1980

aagctggagg agtctttgac agttgagatc tgtgggaaac cgctggatct gagcaacctg     2040

tccctagaag gcatcgcagt gctaaacatc cctagcatgc atggtggctc caacctctgg     2100

ggtgatacca ggagacccca tggggatatc tatgggatca accaggcctt aggtgctaca     2160

gctaaagtca tcaccgaccc tgatatcctg aaaacctgtg taccagacct aagtgacaag     2220

agactggaag tggttgggct ggagggtgca attgagatgg gccaaatcta taccaagctc     2280

aagaatgctg gacgtcggct ggccaagtgc tctgagatca ccttccacac cacaaaaacc     2340

cttcccatgc aaattgacgg agaaccctgg atgcagacgc cctgtacaat caagatcacc     2400

cacaagaacc agatgcccat gctcatgggc ccaccccccc gctccaccaa tttctttggc     2460

ttcttgagct aagggggaca cccttggcct ccaagccagc cttgaaccca cctccctgtc     2520

cctggactct actcccgagg ctctgtacat tgctgccaca tactcctgcc agcttggggg     2580

agtgttcctt caccctcaca gtatttatta tcctgcacca cctcactgtt ccccatgcgc     2640

acacacatac acacacccca aaacacatac attgaaagtg cctcatctga ataaaatgac     2700

ttgtgtttcc cctttgggat ctgctaa                                         2727


<210>  16
<211>  735
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Lys Glu Arg Gly Leu Ile Ser Pro Ser Asp Phe Ala Gln Leu 
1               5                   10                  15      


Gln Lys Tyr Met Glu Tyr Ser Thr Lys Lys Val Ser Asp Val Leu Lys 
            20                  25                  30          


Leu Phe Glu Asp Gly Glu Met Ala Lys Tyr Val Gln Gly Asp Ala Ile 
        35                  40                  45              


Gly Tyr Glu Gly Phe Gln Gln Phe Leu Lys Ile Tyr Leu Glu Val Asp 
    50                  55                  60                  


Asn Val Pro Arg His Leu Ser Leu Ala Leu Phe Gln Ser Phe Glu Thr 
65                  70                  75                  80  


Gly His Cys Leu Asn Glu Thr Asn Val Thr Lys Asp Val Val Cys Leu 
                85                  90                  95      


Asn Asp Val Ser Cys Tyr Phe Ser Leu Leu Glu Gly Gly Arg Pro Glu 
            100                 105                 110         


Asp Lys Leu Glu Phe Thr Phe Lys Leu Tyr Asp Thr Asp Arg Asn Gly 
        115                 120                 125             


Ile Leu Asp Ser Ser Glu Val Asp Lys Ile Ile Leu Gln Met Met Arg 
    130                 135                 140                 


Val Ala Glu Tyr Leu Asp Trp Asp Val Ser Glu Leu Arg Pro Ile Leu 
145                 150                 155                 160 


Gln Glu Met Met Lys Glu Ile Asp Tyr Asp Gly Ser Gly Ser Val Ser 
                165                 170                 175     


Gln Ala Glu Trp Val Arg Ala Gly Ala Thr Thr Val Pro Leu Leu Val 
            180                 185                 190         


Leu Leu Gly Leu Glu Met Thr Leu Lys Asp Asp Gly Gln His Met Trp 
        195                 200                 205             


Arg Pro Lys Arg Phe Pro Arg Pro Val Tyr Cys Asn Leu Cys Glu Ser 
    210                 215                 220                 


Ser Ile Gly Leu Gly Lys Gln Gly Leu Ser Cys Asn Leu Cys Lys Tyr 
225                 230                 235                 240 


Thr Val His Asp Gln Cys Ala Met Lys Ala Leu Pro Cys Glu Val Ser 
                245                 250                 255     


Thr Tyr Ala Lys Ser Arg Lys Asp Ile Gly Val Gln Ser His Val Trp 
            260                 265                 270         


Val Arg Gly Gly Cys Glu Ser Gly Arg Cys Asp Arg Cys Gln Lys Lys 
        275                 280                 285             


Ile Arg Ile Tyr His Ser Leu Thr Gly Leu His Cys Val Trp Cys His 
    290                 295                 300                 


Leu Glu Ile His Asp Asp Cys Leu Gln Ala Val Gly His Glu Cys Asp 
305                 310                 315                 320 


Cys Gly Leu Leu Arg Asp His Ile Leu Pro Pro Ser Ser Ile Tyr Pro 
                325                 330                 335     


Ser Val Leu Ala Ser Gly Pro Asp Arg Lys Asn Ser Lys Thr Ser Gln 
            340                 345                 350         


Lys Thr Met Asp Asp Leu Asn Leu Ser Thr Ser Glu Ala Leu Arg Ile 
        355                 360                 365             


Asp Pro Val Pro Asn Thr His Pro Leu Leu Val Phe Val Asn Pro Lys 
    370                 375                 380                 


Ser Gly Gly Lys Gln Gly Gln Arg Val Leu Trp Lys Phe Gln Tyr Ile 
385                 390                 395                 400 


Leu Asn Pro Arg Gln Val Phe Asn Leu Leu Lys Asp Gly Pro Glu Ile 
                405                 410                 415     


Gly Leu Arg Leu Phe Lys Asp Val Pro Asp Ser Arg Ile Leu Val Cys 
            420                 425                 430         


Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Glu Thr Ile Asp Lys Ala 
        435                 440                 445             


Asn Leu Pro Val Leu Pro Pro Val Ala Val Leu Pro Leu Gly Thr Gly 
    450                 455                 460                 


Asn Asp Leu Ala Arg Cys Leu Arg Trp Gly Gly Gly Tyr Glu Gly Gln 
465                 470                 475                 480 


Asn Leu Ala Lys Ile Leu Lys Asp Leu Glu Met Ser Lys Val Val His 
                485                 490                 495     


Met Asp Arg Trp Ser Val Glu Val Ile Pro Gln Gln Thr Glu Glu Lys 
            500                 505                 510         


Ser Asp Pro Val Pro Phe Gln Ile Ile Asn Asn Tyr Phe Ser Ile Gly 
        515                 520                 525             


Val Asp Ala Ser Ile Ala His Arg Phe His Ile Met Arg Glu Lys Tyr 
    530                 535                 540                 


Pro Glu Lys Phe Asn Ser Arg Met Lys Asn Lys Leu Trp Tyr Phe Glu 
545                 550                 555                 560 


Phe Ala Thr Ser Glu Ser Ile Phe Ser Thr Cys Lys Lys Leu Glu Glu 
                565                 570                 575     


Ser Leu Thr Val Glu Ile Cys Gly Lys Pro Leu Asp Leu Ser Asn Leu 
            580                 585                 590         


Ser Leu Glu Gly Ile Ala Val Leu Asn Ile Pro Ser Met His Gly Gly 
        595                 600                 605             


Ser Asn Leu Trp Gly Asp Thr Arg Arg Pro His Gly Asp Ile Tyr Gly 
    610                 615                 620                 


Ile Asn Gln Ala Leu Gly Ala Thr Ala Lys Val Ile Thr Asp Pro Asp 
625                 630                 635                 640 


Ile Leu Lys Thr Cys Val Pro Asp Leu Ser Asp Lys Arg Leu Glu Val 
                645                 650                 655     


Val Gly Leu Glu Gly Ala Ile Glu Met Gly Gln Ile Tyr Thr Lys Leu 
            660                 665                 670         


Lys Asn Ala Gly Arg Arg Leu Ala Lys Cys Ser Glu Ile Thr Phe His 
        675                 680                 685             


Thr Thr Lys Thr Leu Pro Met Gln Ile Asp Gly Glu Pro Trp Met Gln 
    690                 695                 700                 


Thr Pro Cys Thr Ile Lys Ile Thr His Lys Asn Gln Met Pro Met Leu 
705                 710                 715                 720 


Met Gly Pro Pro Pro Arg Ser Thr Asn Phe Phe Gly Phe Leu Ser 
                725                 730                 735 


<210>  17
<211>  7212
<212>  DNA
<213>  Homo sapiens

<400>  17
agtcacctgc tccgaggtta ccaagccgga atgcagcaag agcgtctgca gctgctacaa       60

ttggtagaag tggcttcggc agatggttgc tgaacaatga cccaccaagg actacagttg      120

tagaagggag aggggagacg ggtatcatat ttcctccctg agatgtatag tgagtggtag      180

taattgcagt gaatccagct cactgtctca acagcctctc acctgcaccg tctcctcccc      240

tgtcttataa ctggaccagc agttaaacag ctgtatagcc ttgtctccct gtctcatttt      300

cccctgagct ccatcagcaa gagtagcaat agcagctgga gaagcggcag ccagagatag      360

gcagggctgg tgcttgcagc cgcgcaaatc gcctcctcct caacacacac acacacacac      420

acacacacac acacacacac acactgcaca gacttccaat atcaacgcgt cttgacataa      480

atcaaggact aagagagact gaagaagagc gttagtcatg gacaacagtt ctttaacaca      540

ttattgaaat tacaagcatc caaagcagtt tcatgtggac agattgcata ttttgaaagc      600

ctgaggtatt ttatcatgaa acatgccatg tggaatcttt gaagcataga cctctgcgca      660

acacctgaat aaagaatctt ttacctggta tgtgacagag cttctcacca ccaccatgac      720

aaaccaggaa aaatgggccc acctcagccc ttcggaattt tcccaacttc agaaatatgc      780

tgagtattct acaaagaaat taaaggatgt tcttgaagaa ttccatggta atggtgtgct      840

tgcaaagtat aatcctgaag ggaaacaaga cattcttaac caaacaatag attttgaagg      900

tttcaaacta ttcatgaaga cattcctgga agccgagctt cctgatgatt tcactgcaca      960

ccttttcatg tcatttagca acaagtttcc tcattctagt ccaatggtaa aaagtaagcc     1020

tgctctccta tcaggcggtc tgagaatgaa taaaggtgcc atcacccctc cccggactac     1080

ttctcctgca aatacgtgtt ccccagaagt aatccatctg aaggacattg tctgttacct     1140

gtctctgctt gaaagaggaa gacctgagga taagcttgag tttatgtttc gcctttatga     1200

cacggatggg aatggcttcc tggacagctc ggagctagaa aatatcatca gtcagatgat     1260

gcatgttgca gaataccttg agtgggatgt cactgaactt aatccaatcc tccatgaaat     1320

gatggaagaa attgactatg atcatgatgg aaccgtgtct ctggaggaat ggattcaagg     1380

aggaatgaca acgattccac ttcttgtgct cctgggctta gaaaataacg tgaaggatga     1440

tggacagcac gtgtggcgac tgaagcactt taacaaacct gcctattgca acctttgcct     1500

gaacatgctg attggcgtgg ggaagcaggg cctctgctgt tccttctgca agtacacagt     1560

ccatgagcgc tgtgtggctc gagcacctcc ctcttgcatc aagacctatg tgaagtccaa     1620

aaggaacact gatgtcatgc accattactg ggttgaaggt aactgcccaa ccaagtgtga     1680

taagtgccac aaaactgtta aatgttacca gggcctgaca ggactgcatt gtgtttggtg     1740

tcagatcaca ctgcataata aatgtgcttc tcatctaaaa cctgaatgtg actgtggacc     1800

tttgaaggac catattttac cacccacaac aatctgtcca gtggtactgc agactctgcc     1860

cacttcagga gtttcagttc ctgaggaaag acaatcaaca gtgaaaaagg aaaagagtgg     1920

ttcccagcag ccaaacaaag tgattgacaa gaataaaatg caaagagcca actctgttac     1980

tgtagatgga caaggcctgc aggtcactcc tgtgcctggt actcacccac ttttagtttt     2040

tgtgaacccc aaaagtggtg gaaaacaagg agaacgaatt tacagaaaat tccagtatct     2100

attaaatcct cgtcaggttt acagtctttc tggaaatgga ccaatgccag ggttaaactt     2160

tttccgtgat gttcctgact tcagagtgtt agcctgtggt ggagatggaa ccgtgggctg     2220

ggttttggat tgcatagaaa aggccaatgt aggcaagcat cctccagttg cgattctgcc     2280

tcttgggact ggcaatgatc tagcaagatg cctgcgatgg ggaggaggtt acgaaggtga     2340

gaatctgatg aaaattctaa aagacattga aaacagcaca gaaatcatgt tggacaggtg     2400

gaagtttgaa gtcataccta atgacaaaga tgagaaagga gacccagtgc cttacagtat     2460

catcaataat tacttttcca ttggcgtgga tgcctccatt gcacacagat tccacatcat     2520

gagagaaaaa cacccagaga aattcaacag tagaatgaag aacaaatttt ggtattttga     2580

gtttggcaca tctgaaactt tctcagccac ctgcaagaag ctacatgaat ctgtagaaat     2640

agaatgtgat ggagtacaga tagatttaat aaacatctct ctggaaggaa ttgctatttt     2700

gaatatacca agcatgcatg gaggatccaa tctttgggga gagtctaaga aaagacgaag     2760

ccatcgacga atagagaaaa aagggtctga caaaaggacc accgtcacag atgccaaaga     2820

gttgaagttt gcaagtcaag atctcagtga ccagctgctg gaggtggtcg gcttggaagg     2880

agccatggag atggggcaaa tatacacagg cctgaaaagt gctggccggc ggctggctca     2940

gtgctcctgc gtggtcatca ggacgagcaa gtctctgcca atgcaaattg atggggagcc     3000

atggatgcag accccatgca caataaaaat tacacacaag aaccaagccc caatgctgat     3060

gggcccgcct ccaaaaaccg gtttattctg ctccctcgtc aaaaggacaa gaaaccgaag     3120

caaggaataa tcctgtgttg tttcactctt agaaattgaa ttagcataat tgggccatgg     3180

aacacatatg ctggaaatct ttgaaccatt tcaagtctcc tgctcatgca aaatcatgga     3240

agtggtttaa cagtttttgt tactaagcta atgtaaaatt cagctattag aaaatttatt     3300

gtctcagttt ttataggcat ctttgcatga agaaagcaga agtttacctg aagtgatact     3360

gcatattttt ggtgcatgca ttcccataga tttttacatc tcccacccaa ctcttcccca     3420

atttcctttt actaacctgt gagaaaaacc cgtgaaacat gaaaaaggaa ataccatggg     3480

aaacgtgatt ctcagtgtga ttccaattat tacgaagcac taatcagtaa cgctacaatg     3540

atcataattg cagattgcta tacgtttccc ttttagaatc agtgtatcag tgacctatga     3600

cttgaggaga aacttttaat tcgaagattt tattaaatag ttgactacaa taccttgcta     3660

tatatacata gtttttcttc aacatcttaa ctcttctgag tggaaataaa aatatcaggc     3720

ataaggtttt ctcatgctga aaaatagaac gcggttttta ttttgcttag ttttcttttt     3780

aattccagaa ataagtgaaa acatgttact tgacagtcaa gtgtggtaat atggcaagcc     3840

ttgttccttt ctgcatgaga atctaggaga gaattcataa ccacaccaat aacgaaatag     3900

aagttttaaa ctatgtgcct aatcaatgtg tttcccacca aagattcaga aaacaatgct     3960

tgagagaaat gggttaatgc ataattaatt aagcattgtg gagcaaattt agggttcctg     4020

tgattaattt tgtgatgact aaaatgctgg aaagcgagtg agttgcccat taattatgat     4080

taaaattctc acctttcaca gacagacaat aagccagaca acacaatcaa agctcaatag     4140

atgatttctt gcttttttca gtcatttata aatataggtg taatttttca tggatcagtt     4200

aagtacactt gaaggaagta aatgattgta tcagtttatt tctagtataa atgggtacct     4260

gtaataatac tgagctcttg gaagcgaatc atgcatgcaa ttagctccct cctcctcacc     4320

tactccactc ccatctttat gacatttcaa atgtttattt ggaaacaaca gcctagatca     4380

ctgttgaagg tgttcatggc atagttggag tctctgactg tttaaagaaa tcacagaaca     4440

gtacttttct tttagtgttt cattaagcct atgatgtaaa atgaaatgct tctgagcagt     4500

cttgtaatat tgttcattca tattgacctg catctcatca ttgcatgttt tatgttttca     4560

aacatgccat aaggaaaacg agtgcctgaa ctgcatgatt tattagtttc tctccactct     4620

gcattaaagt gctaatgatt tatcggttct attttgttat tgattcattc atctttcttt     4680

gaataacaaa tagcatttag tgattctgtt gaacacaatc ctgtgcatgg atttatggat     4740

ttcaagtgaa attgctataa ttttagttct ttggtttgaa aactcaactg aatgctgtta     4800

tatcaaatag ctgctctcaa gcaatgtgct ataatggaag attacgtaca aagtgtattc     4860

ttttagtgtt cctggaacat tggacggtaa atatcaatca acaataagct taattacttt     4920

aaaaataaaa gcttttgaat aaaattaaga cataatttag cattcccagg aaaattatga     4980

ttacaattgc aaatttagta cagcaatcac ttgcgctggt ataaaataaa aaagttgttt     5040

ggcagaagag taatccagac caaaagaaag aaagaaatct caaaacagta acaagtacat     5100

tactgacata atgttacgta acacacacat tgattttttg tatctatggt tgcaggtaat     5160

aaatattttc acatgaattg acaaaatttt ctacaatggg caggcaggct ttgtgtcaaa     5220

aacatatttt gaagccacaa attattttat gttcgctaca acatacaatt atgtcttggc     5280

taccttttat agtatatagt ttgaaggcag caacagtttg tgaatcattc ttaacaatct     5340

gtacagtaga aagctgttgg atagacagtg ggatgagaca aattaaacaa cctgcttata     5400

agatttcaat gattgaaata atgggatgca gcttcacttc agtgtagctg tataactaca     5460

attagtgcta atagtggtta cattttcagt cagatggatt ctttggtacc cataataaat     5520

gttcaaatag gaatccaatt tgacttttct caactcattt tctaaataca ctgatgtact     5580

tgccccttca agtatactgc ccctggggtt tggaaagtag tttttaaaaa cgtaacttga     5640

tgggtttgaa atcagagaag atattctcat cagttttatg acagcttcat atgaaaaata     5700

tatagtttaa ggaaaattct atagtatatt aaaatattga atgatgaatg ttgttagctt     5760

tacaagatgg aaacttctct tctatgtgtg cagataaatt ttcagctatt gagtcgccct     5820

cttttaatat aggagacata aagttttaag tggctgaaac tcttaaatgt aaattaatgc     5880

tggacttaac agcagtcaga aacaaagagg gaaaagagac atgcactctg ctaaacattg     5940

ctaggcactg agttgatgag attccagaga gacatttcag agtaaacctt gatatccacg     6000

cttctaagag ataggaaggg aggtatctac atagaaccag aaagtttaaa agacgtaaat     6060

ttattttttc cacttccttg tgtacaccat gtatttcatg tgaaaatgct gatcaattta     6120

ttgtggtgga aggagatatc ttgcaggaag tttaaaaatt aacattttaa aacagttttt     6180

attttattta aaacaggttc atgtgatcat agccagaata aaacaaaagg ctcagatgtt     6240

tagcctagtc tactgcagac agaaatttaa atccagtgag ggctaatgaa tcacatacgt     6300

gtttccacat tttattttgt tttcgttttt taggcatatg ggaagtagtt gcaatttttc     6360

agggaagaat atgttttgaa tctcacactg tattctcctt gaatctcaca ctgtattctt     6420

gaatgagaca agattttgag atcattcttt tcctttttgt gtcaacgtta gtttgttgtt     6480

cattggttat aaaaaggaaa atgtggccag gcgcaatggc ttacgcctgt aatcccagca     6540

ctttgggaga cagaggcagg cagatcacaa ggtcaggagt tcaagaccag cctggccaat     6600

atggtgaaac ctcgtctcta ctaaaaatac aaaaattagc caggcatggt ggcacatgcc     6660

tgtaatccca gctactcggg aggctgaggc agaagaattg cttgaactcg ggaggctgcg     6720

gttgcagtga gccaagatca caccactgca ctccagcctg ggtgacagag ccagactctg     6780

tctcaaaaaa aaaaaggaaa atgtactttt catggcacgt ataaccccca aaggattatt     6840

caatactgaa caattaaata ataattgaat aatattgaat catgttctcc gttatttttc     6900

aaataactga ataatatctc tattaaaaga ttaaaccctt gtaacatata ttaaagctgt     6960

aaactttaag aaaataaata aataaaaccc tgtaaaagag cttttatttt gtgagaggca     7020

gaaatcacca cttaaaactc ccaattaaat tctgctatat ttaaataaag tttgagtaaa     7080

ctcacatttg agagattctg tataacctta ttgtgtttaa aaacatggaa cttaattata     7140

gtaccttaat tattttctca gaaatgatat atacaatatc ctgttttttg aaataaaaac     7200

gttaaccact ca                                                         7212


<210>  18
<211>  804
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Thr Asn Gln Glu Lys Trp Ala His Leu Ser Pro Ser Glu Phe Ser 
1               5                   10                  15      


Gln Leu Gln Lys Tyr Ala Glu Tyr Ser Thr Lys Lys Leu Lys Asp Val 
            20                  25                  30          


Leu Glu Glu Phe His Gly Asn Gly Val Leu Ala Lys Tyr Asn Pro Glu 
        35                  40                  45              


Gly Lys Gln Asp Ile Leu Asn Gln Thr Ile Asp Phe Glu Gly Phe Lys 
    50                  55                  60                  


Leu Phe Met Lys Thr Phe Leu Glu Ala Glu Leu Pro Asp Asp Phe Thr 
65                  70                  75                  80  


Ala His Leu Phe Met Ser Phe Ser Asn Lys Phe Pro His Ser Ser Pro 
                85                  90                  95      


Met Val Lys Ser Lys Pro Ala Leu Leu Ser Gly Gly Leu Arg Met Asn 
            100                 105                 110         


Lys Gly Ala Ile Thr Pro Pro Arg Thr Thr Ser Pro Ala Asn Thr Cys 
        115                 120                 125             


Ser Pro Glu Val Ile His Leu Lys Asp Ile Val Cys Tyr Leu Ser Leu 
    130                 135                 140                 


Leu Glu Arg Gly Arg Pro Glu Asp Lys Leu Glu Phe Met Phe Arg Leu 
145                 150                 155                 160 


Tyr Asp Thr Asp Gly Asn Gly Phe Leu Asp Ser Ser Glu Leu Glu Asn 
                165                 170                 175     


Ile Ile Ser Gln Met Met His Val Ala Glu Tyr Leu Glu Trp Asp Val 
            180                 185                 190         


Thr Glu Leu Asn Pro Ile Leu His Glu Met Met Glu Glu Ile Asp Tyr 
        195                 200                 205             


Asp His Asp Gly Thr Val Ser Leu Glu Glu Trp Ile Gln Gly Gly Met 
    210                 215                 220                 


Thr Thr Ile Pro Leu Leu Val Leu Leu Gly Leu Glu Asn Asn Val Lys 
225                 230                 235                 240 


Asp Asp Gly Gln His Val Trp Arg Leu Lys His Phe Asn Lys Pro Ala 
                245                 250                 255     


Tyr Cys Asn Leu Cys Leu Asn Met Leu Ile Gly Val Gly Lys Gln Gly 
            260                 265                 270         


Leu Cys Cys Ser Phe Cys Lys Tyr Thr Val His Glu Arg Cys Val Ala 
        275                 280                 285             


Arg Ala Pro Pro Ser Cys Ile Lys Thr Tyr Val Lys Ser Lys Arg Asn 
    290                 295                 300                 


Thr Asp Val Met His His Tyr Trp Val Glu Gly Asn Cys Pro Thr Lys 
305                 310                 315                 320 


Cys Asp Lys Cys His Lys Thr Val Lys Cys Tyr Gln Gly Leu Thr Gly 
                325                 330                 335     


Leu His Cys Val Trp Cys Gln Ile Thr Leu His Asn Lys Cys Ala Ser 
            340                 345                 350         


His Leu Lys Pro Glu Cys Asp Cys Gly Pro Leu Lys Asp His Ile Leu 
        355                 360                 365             


Pro Pro Thr Thr Ile Cys Pro Val Val Leu Gln Thr Leu Pro Thr Ser 
    370                 375                 380                 


Gly Val Ser Val Pro Glu Glu Arg Gln Ser Thr Val Lys Lys Glu Lys 
385                 390                 395                 400 


Ser Gly Ser Gln Gln Pro Asn Lys Val Ile Asp Lys Asn Lys Met Gln 
                405                 410                 415     


Arg Ala Asn Ser Val Thr Val Asp Gly Gln Gly Leu Gln Val Thr Pro 
            420                 425                 430         


Val Pro Gly Thr His Pro Leu Leu Val Phe Val Asn Pro Lys Ser Gly 
        435                 440                 445             


Gly Lys Gln Gly Glu Arg Ile Tyr Arg Lys Phe Gln Tyr Leu Leu Asn 
    450                 455                 460                 


Pro Arg Gln Val Tyr Ser Leu Ser Gly Asn Gly Pro Met Pro Gly Leu 
465                 470                 475                 480 


Asn Phe Phe Arg Asp Val Pro Asp Phe Arg Val Leu Ala Cys Gly Gly 
                485                 490                 495     


Asp Gly Thr Val Gly Trp Val Leu Asp Cys Ile Glu Lys Ala Asn Val 
            500                 505                 510         


Gly Lys His Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly Asn Asp 
        515                 520                 525             


Leu Ala Arg Cys Leu Arg Trp Gly Gly Gly Tyr Glu Gly Glu Asn Leu 
    530                 535                 540                 


Met Lys Ile Leu Lys Asp Ile Glu Asn Ser Thr Glu Ile Met Leu Asp 
545                 550                 555                 560 


Arg Trp Lys Phe Glu Val Ile Pro Asn Asp Lys Asp Glu Lys Gly Asp 
                565                 570                 575     


Pro Val Pro Tyr Ser Ile Ile Asn Asn Tyr Phe Ser Ile Gly Val Asp 
            580                 585                 590         


Ala Ser Ile Ala His Arg Phe His Ile Met Arg Glu Lys His Pro Glu 
        595                 600                 605             


Lys Phe Asn Ser Arg Met Lys Asn Lys Phe Trp Tyr Phe Glu Phe Gly 
    610                 615                 620                 


Thr Ser Glu Thr Phe Ser Ala Thr Cys Lys Lys Leu His Glu Ser Val 
625                 630                 635                 640 


Glu Ile Glu Cys Asp Gly Val Gln Ile Asp Leu Ile Asn Ile Ser Leu 
                645                 650                 655     


Glu Gly Ile Ala Ile Leu Asn Ile Pro Ser Met His Gly Gly Ser Asn 
            660                 665                 670         


Leu Trp Gly Glu Ser Lys Lys Arg Arg Ser His Arg Arg Ile Glu Lys 
        675                 680                 685             


Lys Gly Ser Asp Lys Arg Thr Thr Val Thr Asp Ala Lys Glu Leu Lys 
    690                 695                 700                 


Phe Ala Ser Gln Asp Leu Ser Asp Gln Leu Leu Glu Val Val Gly Leu 
705                 710                 715                 720 


Glu Gly Ala Met Glu Met Gly Gln Ile Tyr Thr Gly Leu Lys Ser Ala 
                725                 730                 735     


Gly Arg Arg Leu Ala Gln Cys Ser Cys Val Val Ile Arg Thr Ser Lys 
            740                 745                 750         


Ser Leu Pro Met Gln Ile Asp Gly Glu Pro Trp Met Gln Thr Pro Cys 
        755                 760                 765             


Thr Ile Lys Ile Thr His Lys Asn Gln Ala Pro Met Leu Met Gly Pro 
    770                 775                 780                 


Pro Pro Lys Thr Gly Leu Phe Cys Ser Leu Val Lys Arg Thr Arg Asn 
785                 790                 795                 800 


Arg Ser Lys Glu 
                


<210>  19
<211>  6230
<212>  DNA
<213>  Homo sapiens

<400>  19
agagacacga atatgtttca gccgcaacag gctgcgtttc agccggaaga gtgaaagggc       60

accttgaaaa cgcaagttta tgaatatgtt tctgtacttt cagaccatca tcaaagaggg      120

gatgctgacc aaacagaaca attcattcca gcgatcaaaa aggagatact ttaagcttcg      180

agggcgaacg ctttactatg ccaaaacggc aaagtcaatc atatttgatg aggtggatct      240

gacagatgcc agcgtagctg aatccagtac caaaaacgtc aacaacagtt ttacggtcat      300

aactccatgc aggaagctca tcttgtgtgc tgataacaga aaagaaatgg aagattggat      360

tgcagcatta aagactgtgc agaacaggga gcactttgag cccacccagt acagcatgga      420

ccacttctca gggatgcaca attggtacgc ctgttcccac gcgaggccga cctactgcaa      480

tgtgtgccgt gaggctctgt ctggggtcac gtcgcacggg ctgtcctgcg aggtgtgcaa      540

atttaaggcc cacaagcgct gtgctgtgcg tgcaaccaat aactgcaagt ggaccacact      600

ggcctcgatc gggaaggaca tcattgaaga tgcagatggg attgcaatgc cccaccagtg      660

gttggaagga aacctacctg tgagcgccaa gtgcactgtg tgcgacaaga cctgtggcag      720

tgtgctgcgc ctgcaggact ggcgctgcct ctggtgcaag gccatggttc acacatcgtg      780

taaagaatcc ttgctgacca agtgcccact tggcctgtgc aaagtgtcag tcatcccacc      840

cacggctctc aacagcatcg actccgatgg gttctggaag gccagctgtc ctccttcttg      900

cacaagccca ctgttggtct tcgtcaattc aaaaagtggg gacaaccagg gtgtgaagtt      960

cctcagaaga ttcaaacagc tactaaaccc cgcccaggtc ttcgacctca tgaacggagg     1020

cccacacctc ggcttacggt tattccagaa gtttgacaca ttccggattc tggtttgtgg     1080

cggggatgga agtgttggct gggtcctctc cgaaatcgac agcctcaacc ttcataaaca     1140

gtgtcagctg ggagtgctgc cgctcggcac agggaacgac ttggcccgag tactgggctg     1200

gggctcagcc tgcgatgacg acacccagct cccccagatc ttggagaagt tggagagagc     1260

cagcaccaag atgctggaca ggtggagcgt catggcatac gaggccaagc tcccccggca     1320

ggcctcctcc tctaccgtca ccgaagactt cagcgaggat tccgaggtac agcagattct     1380

cttctatgaa gactcggttg cagcccacct ttctaaaatc ctcacctcgg accagcactc     1440

ggtggtcatc tcctcggcca aagtgctctg tgagacggtg aaggacttcg tggcacgggt     1500

ggggaaggcc tatgagaaga cgaccgagag ctcggaggag tcagaggtca tggccaagaa     1560

gtgctctgtc ctgaaagaga agctggattc ccttctcaag accttggacg atgagtccca     1620

ggcctcgtcc tctctgccca acccgccccc caccattgcc gaggaggctg aagatggaga     1680

tgggtcgggc agcatctgcg gttccaccgg agaccgcttg gtggcatcag cttgcccggc     1740

ccggccgcag atattccggc ctcgagaaca gctcatgctg agagccaaca gcctgaagaa     1800

agcaattcgt cagatcatag aacacacaga aaaagctgtc gatgagcaga atgcccagac     1860

ccaggagcag gagggcttcg tcctgggcct ctctgagtca gaggagaaga tggaccacag     1920

agtgtgccca ccactgtccc acagcgagag cttcggggtc cccaagggga ggagccagcg     1980

caaagtgtcg aaatctccgt gtgaaaagct gatcagcaaa gggagtctgt ccctaggcag     2040

ttctgcttcc cttccgcccc agccgggaag ccgggacggc ctgcctgcgc tcaacaccaa     2100

gatcctgtac ccaaatgtcc gggctggaat gtctggttcc ttacccggtg gctcagtcat     2160

cagtcgcctg ttaattaatg ctgatccctt caactctgaa ccagaaaccc tagagtatta     2220

cacggagaaa tgtgtcatga acaactattt tggcattggc ctggatgcga agatatccct     2280

ggactttaac aacaagcgcg atgagcaccc agagaagtgc aggagccgaa ccaagaacat     2340

gatgtggtat ggagttcttg gaaccaaaga gttgctgcac agaacctaca agaacctgga     2400

gcaaaaggtc ttgctggagt gtgacgggcg acccatccca ctccccagtc ttcagggaat     2460

tgctgtcctt aacattccca gctatgccgg aggaaccaac ttctgggggg gtaccaagga     2520

agatgatact ttcgcagctc catcattcga tgacaagatt ctggaggtgg tcgccgtgtt     2580

cggcagcatg cagatggccg tctctcgagt catcaggcta cagcatcatc ggatcgccca     2640

gtgtcgcacg gtgaagatct ccatccttgg ggatgagggc gtgcctgtgc aggtggacgg     2700

agaggcctgg gtccagccgc cagggtacat tcggattgtc cacaagaacc gggcacagac     2760

actgaccaga gacagggcat ttgagagcac cctgaagtcc tgggaagaca agcagaagtg     2820

cgagctgccc cgccctccat cctgttccct gcacccggag atgctgtccg aggaggaggc     2880

cacccagatg gaccagtttg ggcaggcagc aggggtcctc attcacagta tccgagaaat     2940

agctcagtct caccgggaca tggagcagga actggcccac gccgtcaatg ccagctccaa     3000

gtccatggac cgtgtgtatg gcaagcccag aaccacagag gggctcaact gcagcttcgt     3060

cctggaaatg gtgaataact tcagagctct gcgcagtgag acggagctgc tgctgtctgg     3120

gaagatggcc ctgcagctgg atccgcctca gaaggagcag ctggggagtg ctcttgccga     3180

gatggaccga cagctcagga ggctggcaga caccccgtgg ctctgccagt ccgcagagcc     3240

cggcgacgaa gagagtgtga tgctggatct tgccaagcgc agtcgcagtg gtaaattccg     3300

cctcgtgacc aagtttaaaa aggagaaaaa caacaagaac aaagaagctc acagtagcct     3360

gggagccccg gttcacctct gggggacaga ggaggttgct gcctggctgg agcacctcag     3420

tctctgtgag tataaggaca tcttcacacg gcacgacatc cggggctctg agctcctgca     3480

cctggagcgg agggacctca aggacctggg cgtgaccaag gtgggccaca tgaagaggat     3540

cctgtgtggc atcaaggagc tgagccgcag cgcccccgcc gtcgaggcct agcctctgtc     3600

ctctcagcct gtggcctcca catccccgcc gccgaggcct agcctccgcc ctctcagcct     3660

gtggcctctg cgcctcctgc cactgaggcc ctgggcagat gctgcagccc gcccccttct     3720

catggtgcta cttcctctgt cagctacaga aagcctccgt gacaccgtcc accagagctc     3780

tggggtctcg aacataacaa cacagctacc tttgaaacaa cactttctcc agctcagagt     3840

cacctggggc acatgtgtca cggccactca gctctcgccc gcctgtgctg tgggccaggg     3900

aatccagcgg cgtctggcct cctgggcact gcttgcctgg cctcgtgctt ggattgtccc     3960

gggggctcct ctccgtgtgt ccttctgtgg ccgcaccgtg tggctccgcc tcctggcccc     4020

cagccagttc tcagaaacgt ggctggggcc cagcacagca gcctgcaagg gcccctgttt     4080

gttgatgcag cttttgttga acaaaaatcg tgctctttcc tggtttgaaa gtagcatgga     4140

tgtttccagt cttgttgatt gtaatttgac gtgaagagaa aaaaaaattc ctcctgcgtg     4200

agccaaggca gcgggtgctg tttcccaggc ggggagcccc tccctgggtg tcacagggcc     4260

tgtgctcctc cctcctccat cctctctcct cccgctcctc cctcccccca ctgtgggctg     4320

gggacgcctg cccttctgtc tccggacgct ctaggcgagt tcagcttggg gtgtgagtga     4380

gacagcttgc cagctgcatc cctgcagaca gaggatgtgt gtccacatga gtgtttctgt     4440

gtgggaaatg cttcctggct ctgggaaact ttttctgccc attctgtggt tcccagggag     4500

cgtggccctg gtgggccagg ggtggtttga cctcttcagc ccgtccggtg gcctggaggc     4560

cggaggctct cctgagtgtc tgcccctgca gtggcttctt gtcgcctgct gctgggcgtg     4620

atgtcgctgg aggtgctggc agggactctg atttggtggt ccgcgctgcc cctgccctgc     4680

ctctgtcctg gctctgaact agtagatgat ggtgccagag ggcagggagc tcgcctgggg     4740

agagggctgt gccccgtagg gacagtgccc aggtgaagga tgcccctggt cctccagggc     4800

actgactttg cccttttttc ccgttgatag tcatggctca gaggtgcttg taaatgtctt     4860

gggaagaggt ttctgtaacc cctgccctgg tgtgaggagg aaatggctct ggcctggctg     4920

cctggccgtg gcttctcttt ggctcccaaa gagaaggaca gtgttgggag tatctgccgt     4980

ggcttctctt tggctcccaa agagaaggac agtgttggga gtatctgccg gcgctgtcca     5040

ggtcctttag tcagcgtcac tccatctgat gtgcagaagc tgggctgcac ctgcgggggt     5100

gggcatagac cgggctgggt ctgcagcagc ccctggtcct gagcaggcgg cagtgaacag     5160

cactggccca cctcccactc acagcccctc tgtcccctct gcagtgcacc caggtgggcc     5220

cctctgcgtg cctttgggtg ctcccctctc gtggtcgttc tggcccgagg cccttagagt     5280

atggaggctg agccaggcct tgggtttccc cagcacagcc tcctgtcgct gcatgcgacg     5340

tgttgggatt tttggatgaa agactctccc acgctctgtt ggtggactta gctgcctcac     5400

tggaagtgat gtgggtggaa ggtggttgta tgttaccttt tccacctctc attgttttcc     5460

ccagaacatt gtagatgggg gttggcagag ggagaaataa gccagccacg gcagtcgctt     5520

ggtttcccag gtggaatggg ctaacacagg agatgatggg aacctgtccc gcagtccctg     5580

catgaccatt ggccctgctg gcctggcgat gtgggcatcc tggggttctt agggtcccag     5640

aacaagcccc aggcaagctg gaacttgggt ggggagggga catgaggagg ataaacagct     5700

gactgtggct tcaaggacat cagggccacc ccaagtcctc agtgtcctac tcctggcaag     5760

gagttgggtt tggatcaaaa gtgtttaaaa ttaatatgtt gtcagtgatt agaacaacac     5820

tgtttacata aaaaccattt ttctaattct aacaagttag aatgtgagga aggaatgaac     5880

atgagtgttt aggaacctgc cctttggtgc tgggctggcg tcccgcactg gggtgtcctc     5940

gctgtctggg ggctgctctg ctgccccggc ccaggtcccc ttgtggtgtt gccagacggg     6000

cctcatggtc tgctgtgcag agagaggcag gaaggatccc tgaagagtct tggagaaaag     6060

gttctgtgcc ctcaggtggg gcttaccccc tcgtatttat aatcttaatt tatatagtga     6120

ccaccgtgga aacaaacgcc tcttgtattg tcatgtacat agtccatacc tgagtgctgt     6180

acataagttg ttctgtgtat aaataaaaca agcctgtttt tgatcttcca                6230


<210>  20
<211>  1170
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asn Met Phe Leu Tyr Phe Gln Thr Ile Ile Lys Glu Gly Met Leu 
1               5                   10                  15      


Thr Lys Gln Asn Asn Ser Phe Gln Arg Ser Lys Arg Arg Tyr Phe Lys 
            20                  25                  30          


Leu Arg Gly Arg Thr Leu Tyr Tyr Ala Lys Thr Ala Lys Ser Ile Ile 
        35                  40                  45              


Phe Asp Glu Val Asp Leu Thr Asp Ala Ser Val Ala Glu Ser Ser Thr 
    50                  55                  60                  


Lys Asn Val Asn Asn Ser Phe Thr Val Ile Thr Pro Cys Arg Lys Leu 
65                  70                  75                  80  


Ile Leu Cys Ala Asp Asn Arg Lys Glu Met Glu Asp Trp Ile Ala Ala 
                85                  90                  95      


Leu Lys Thr Val Gln Asn Arg Glu His Phe Glu Pro Thr Gln Tyr Ser 
            100                 105                 110         


Met Asp His Phe Ser Gly Met His Asn Trp Tyr Ala Cys Ser His Ala 
        115                 120                 125             


Arg Pro Thr Tyr Cys Asn Val Cys Arg Glu Ala Leu Ser Gly Val Thr 
    130                 135                 140                 


Ser His Gly Leu Ser Cys Glu Val Cys Lys Phe Lys Ala His Lys Arg 
145                 150                 155                 160 


Cys Ala Val Arg Ala Thr Asn Asn Cys Lys Trp Thr Thr Leu Ala Ser 
                165                 170                 175     


Ile Gly Lys Asp Ile Ile Glu Asp Ala Asp Gly Ile Ala Met Pro His 
            180                 185                 190         


Gln Trp Leu Glu Gly Asn Leu Pro Val Ser Ala Lys Cys Thr Val Cys 
        195                 200                 205             


Asp Lys Thr Cys Gly Ser Val Leu Arg Leu Gln Asp Trp Arg Cys Leu 
    210                 215                 220                 


Trp Cys Lys Ala Met Val His Thr Ser Cys Lys Glu Ser Leu Leu Thr 
225                 230                 235                 240 


Lys Cys Pro Leu Gly Leu Cys Lys Val Ser Val Ile Pro Pro Thr Ala 
                245                 250                 255     


Leu Asn Ser Ile Asp Ser Asp Gly Phe Trp Lys Ala Ser Cys Pro Pro 
            260                 265                 270         


Ser Cys Thr Ser Pro Leu Leu Val Phe Val Asn Ser Lys Ser Gly Asp 
        275                 280                 285             


Asn Gln Gly Val Lys Phe Leu Arg Arg Phe Lys Gln Leu Leu Asn Pro 
    290                 295                 300                 


Ala Gln Val Phe Asp Leu Met Asn Gly Gly Pro His Leu Gly Leu Arg 
305                 310                 315                 320 


Leu Phe Gln Lys Phe Asp Thr Phe Arg Ile Leu Val Cys Gly Gly Asp 
                325                 330                 335     


Gly Ser Val Gly Trp Val Leu Ser Glu Ile Asp Ser Leu Asn Leu His 
            340                 345                 350         


Lys Gln Cys Gln Leu Gly Val Leu Pro Leu Gly Thr Gly Asn Asp Leu 
        355                 360                 365             


Ala Arg Val Leu Gly Trp Gly Ser Ala Cys Asp Asp Asp Thr Gln Leu 
    370                 375                 380                 


Pro Gln Ile Leu Glu Lys Leu Glu Arg Ala Ser Thr Lys Met Leu Asp 
385                 390                 395                 400 


Arg Trp Ser Val Met Ala Tyr Glu Ala Lys Leu Pro Arg Gln Ala Ser 
                405                 410                 415     


Ser Ser Thr Val Thr Glu Asp Phe Ser Glu Asp Ser Glu Val Gln Gln 
            420                 425                 430         


Ile Leu Phe Tyr Glu Asp Ser Val Ala Ala His Leu Ser Lys Ile Leu 
        435                 440                 445             


Thr Ser Asp Gln His Ser Val Val Ile Ser Ser Ala Lys Val Leu Cys 
    450                 455                 460                 


Glu Thr Val Lys Asp Phe Val Ala Arg Val Gly Lys Ala Tyr Glu Lys 
465                 470                 475                 480 


Thr Thr Glu Ser Ser Glu Glu Ser Glu Val Met Ala Lys Lys Cys Ser 
                485                 490                 495     


Val Leu Lys Glu Lys Leu Asp Ser Leu Leu Lys Thr Leu Asp Asp Glu 
            500                 505                 510         


Ser Gln Ala Ser Ser Ser Leu Pro Asn Pro Pro Pro Thr Ile Ala Glu 
        515                 520                 525             


Glu Ala Glu Asp Gly Asp Gly Ser Gly Ser Ile Cys Gly Ser Thr Gly 
    530                 535                 540                 


Asp Arg Leu Val Ala Ser Ala Cys Pro Ala Arg Pro Gln Ile Phe Arg 
545                 550                 555                 560 


Pro Arg Glu Gln Leu Met Leu Arg Ala Asn Ser Leu Lys Lys Ala Ile 
                565                 570                 575     


Arg Gln Ile Ile Glu His Thr Glu Lys Ala Val Asp Glu Gln Asn Ala 
            580                 585                 590         


Gln Thr Gln Glu Gln Glu Gly Phe Val Leu Gly Leu Ser Glu Ser Glu 
        595                 600                 605             


Glu Lys Met Asp His Arg Val Cys Pro Pro Leu Ser His Ser Glu Ser 
    610                 615                 620                 


Phe Gly Val Pro Lys Gly Arg Ser Gln Arg Lys Val Ser Lys Ser Pro 
625                 630                 635                 640 


Cys Glu Lys Leu Ile Ser Lys Gly Ser Leu Ser Leu Gly Ser Ser Ala 
                645                 650                 655     


Ser Leu Pro Pro Gln Pro Gly Ser Arg Asp Gly Leu Pro Ala Leu Asn 
            660                 665                 670         


Thr Lys Ile Leu Tyr Pro Asn Val Arg Ala Gly Met Ser Gly Ser Leu 
        675                 680                 685             


Pro Gly Gly Ser Val Ile Ser Arg Leu Leu Ile Asn Ala Asp Pro Phe 
    690                 695                 700                 


Asn Ser Glu Pro Glu Thr Leu Glu Tyr Tyr Thr Glu Lys Cys Val Met 
705                 710                 715                 720 


Asn Asn Tyr Phe Gly Ile Gly Leu Asp Ala Lys Ile Ser Leu Asp Phe 
                725                 730                 735     


Asn Asn Lys Arg Asp Glu His Pro Glu Lys Cys Arg Ser Arg Thr Lys 
            740                 745                 750         


Asn Met Met Trp Tyr Gly Val Leu Gly Thr Lys Glu Leu Leu His Arg 
        755                 760                 765             


Thr Tyr Lys Asn Leu Glu Gln Lys Val Leu Leu Glu Cys Asp Gly Arg 
    770                 775                 780                 


Pro Ile Pro Leu Pro Ser Leu Gln Gly Ile Ala Val Leu Asn Ile Pro 
785                 790                 795                 800 


Ser Tyr Ala Gly Gly Thr Asn Phe Trp Gly Gly Thr Lys Glu Asp Asp 
                805                 810                 815     


Thr Phe Ala Ala Pro Ser Phe Asp Asp Lys Ile Leu Glu Val Val Ala 
            820                 825                 830         


Val Phe Gly Ser Met Gln Met Ala Val Ser Arg Val Ile Arg Leu Gln 
        835                 840                 845             


His His Arg Ile Ala Gln Cys Arg Thr Val Lys Ile Ser Ile Leu Gly 
    850                 855                 860                 


Asp Glu Gly Val Pro Val Gln Val Asp Gly Glu Ala Trp Val Gln Pro 
865                 870                 875                 880 


Pro Gly Tyr Ile Arg Ile Val His Lys Asn Arg Ala Gln Thr Leu Thr 
                885                 890                 895     


Arg Asp Arg Ala Phe Glu Ser Thr Leu Lys Ser Trp Glu Asp Lys Gln 
            900                 905                 910         


Lys Cys Glu Leu Pro Arg Pro Pro Ser Cys Ser Leu His Pro Glu Met 
        915                 920                 925             


Leu Ser Glu Glu Glu Ala Thr Gln Met Asp Gln Phe Gly Gln Ala Ala 
    930                 935                 940                 


Gly Val Leu Ile His Ser Ile Arg Glu Ile Ala Gln Ser His Arg Asp 
945                 950                 955                 960 


Met Glu Gln Glu Leu Ala His Ala Val Asn Ala Ser Ser Lys Ser Met 
                965                 970                 975     


Asp Arg Val Tyr Gly Lys Pro Arg Thr Thr Glu Gly Leu Asn Cys Ser 
            980                 985                 990         


Phe Val Leu Glu Met Val Asn Asn  Phe Arg Ala Leu Arg  Ser Glu Thr 
        995                 1000                 1005             


Glu Leu  Leu Leu Ser Gly Lys  Met Ala Leu Gln Leu  Asp Pro Pro 
    1010                 1015                 1020             


Gln Lys  Glu Gln Leu Gly Ser  Ala Leu Ala Glu Met  Asp Arg Gln 
    1025                 1030                 1035             


Leu Arg  Arg Leu Ala Asp Thr  Pro Trp Leu Cys Gln  Ser Ala Glu 
    1040                 1045                 1050             


Pro Gly  Asp Glu Glu Ser Val  Met Leu Asp Leu Ala  Lys Arg Ser 
    1055                 1060                 1065             


Arg Ser  Gly Lys Phe Arg Leu  Val Thr Lys Phe Lys  Lys Glu Lys 
    1070                 1075                 1080             


Asn Asn  Lys Asn Lys Glu Ala  His Ser Ser Leu Gly  Ala Pro Val 
    1085                 1090                 1095             


His Leu  Trp Gly Thr Glu Glu  Val Ala Ala Trp Leu  Glu His Leu 
    1100                 1105                 1110             


Ser Leu  Cys Glu Tyr Lys Asp  Ile Phe Thr Arg His  Asp Ile Arg 
    1115                 1120                 1125             


Gly Ser  Glu Leu Leu His Leu  Glu Arg Arg Asp Leu  Lys Asp Leu 
    1130                 1135                 1140             


Gly Val  Thr Lys Val Gly His  Met Lys Arg Ile Leu  Cys Gly Ile 
    1145                 1150                 1155             


Lys Glu  Leu Ser Arg Ser Ala  Pro Ala Val Glu Ala  
    1160                 1165                 1170 


<210>  21
<211>  8608
<212>  DNA
<213>  Homo sapiens

<400>  21
aagcgtttcc cccgcccggc ttcatccctg ctggcggccc agcgtcgttc tcctcctgcg       60

cgaggcggcc aaggcctgct ggcccggagc cgcgcctcca cccgcgcgag gtatcgtcct      120

tggagaagat ggaagcggag aggcggccgg cgccgggctc gccctccgag ggcctgtttg      180

cggacgggca cctgatcttg tggacgctgt gctcggtcct gctgccggtg ttcatcacct      240

tctggtgtag cctccagcgg tcgcgccggc agctgcaccg cagggacatc ttccgcaaga      300

gcaagcacgg gtggcgcgac acggacctgt tcagccagcc cacctactgc tgcgtgtgcg      360

cgcagcacat tctgcagggc gccttctgcg actgctgcgg gctccgcgtg gacgagggct      420

gcctcaggaa ggccgacaag cgcttccagt gcaaggagat tatgctcaag aatgacacca      480

aggtcctgga cgccatgccc caccactgga tccggggcaa cgtgcccctg tgcagttact      540

gtatggtttg caagcagcag tgtggctgtc aacccaagct ttgcgattac aggtgcattt      600

ggtgccagaa aacagtacat gatgagtgca tgaaaaatag tttaaagaat gaaaaatgtg      660

attttggaga attcaaaaac ctaatcattc caccaagtta tttaacatcc attaatcaga      720

tgcgtaaaga caaaaaaaca gattatgaag tgctagcctc taagcttgga aagcagtgga      780

ccccattaat aatcctggcc aactctcgta gtggaactaa tatgggagaa ggactgttgg      840

gagaatttag gatcttgttg aatccagtcc aggtttttga tgtaactaaa actcctccta      900

tcaaagccct acaactctgt actcttctcc catattattc agctcgagta cttgtttgtg      960

gaggggatgg gactgtaggg tgggtcctgg atgcagttga tgacatgaag attaagggac     1020

aagaaaagta cattccacaa gttgcagttt tgcctctggg aacaggcaac gatctatcca     1080

atacattggg ttggggtaca ggttatgctg gagaaattcc agttgcgcag gttttgcgaa     1140

atgtaatgga agcagatgga attaaactag atcgatggaa agttcaagta acaaataaag     1200

gatactacaa cttaagaaaa cccaaggaat tcacaatgaa caactatttt tctgttggac     1260

ctgatgctct catggctctc aattttcatg ctcatcgtga gaaggcacca tctctgtttt     1320

ctagcagaat tcttaataag gcggtttact tattctatgg aaccaaagat tgtttagtgc     1380

aagaatgtaa agatttgaat aaaaaagttg agctagaact ggatggtgag cgagtagcac     1440

tgcccagctt ggaaggtatt atagttctga acatcggata ctggggcggt ggctgcagac     1500

tatgggaagg gatgggggac gagacttacc ctctagccag gcatgacgat ggtctgctgg     1560

aagtcgttgg agtatatggg tctttccact gtgctcagat tcaagtaaaa ctggctaatc     1620

cttttcgaat aggacaggca catacagtga ggctgatttt gaagtgctcc atgatgccaa     1680

tgcaggtgga tggggagcct tgggcccaag ggccctgcac tgtcaccata actcacaaga     1740

cacatgcaat gatgttatat ttctctggag aacaaacaga tgatgacatc tctagtactt     1800

cggatcaaga agatataaag gcgactgaat agatggatga gggagtgaaa actttgcata     1860

gaatcctcac gcaagtagat acatgttcat ccaaaagtat taatagaaat tctctatcag     1920

ctattcagtc ttaatttcac tagtagtata atgggtatac atttttgtaa atagcatccc     1980

caaaccagcc agccttcagt tatttacaaa tgtttgttct tttttcagca aaatacttca     2040

aatgaatagt attaacttac aaaaagtcac aaaaacttac atgagagtga aaatttgtta     2100

tgactgtttt gagagtggga ctcactctga agtatgtgct gtctcatgtc ttatttttga     2160

accatgcata tgatggacac acaatggatg gacacattat atctccaaca aggtgtgggt     2220

ggaaagatca aattaacctg cttttttgaa aggaaatgat tactgtcaaa ccagcatggt     2280

taattgtgag catcctcctg cagcatgccc cttaagattt tctacaaccc aaaccaagtg     2340

tatgtattga tttctaggaa cccccaaaag gagaatagta aaaaaagatc atacttaaaa     2400

tttgtattac aatttttatt ttaggaactt attcagacac gtaaatgttg tttaattctg     2460

taggtaacca tttgagctgc aattcaggat cttttttata acaccagtgt agccaaaaga     2520

gaaacagata agtgaattgg taagaaataa gattcagagc acttgggatt gtaagttata     2580

ggttctgagc tgaactgttt atcagccgct ctttttatta aaagacagtg tcaacacttc     2640

aaaaaacgtg cttaaaggag acaacggtga gattaattgc ttagaaaaag ctcaaggctg     2700

actgataagt tttaaaaatt tggtggtctt gtagtatttt gaaatacagt agtcttttaa     2760

cagaatttcc ccttagggag gtaagtggac agaaatcttt gctaaaatgt ttatatcata     2820

tttattttaa aatgagagag atatattttt aaattattta ttatttacct tgtggtatgg     2880

tacctgtgtt tagtgtttac gttctgtagc tttatttaat aagttaaatt gatcacataa     2940

attctgctag tcacaatcag atagaaattt agtctattaa ttaaaattct aatttaattc     3000

tcctgacaga aatctagata ttcttattct tcacaaatat tcctcattgt attgaaaaat     3060

gaaggagggc atgaaaagca ctagggaact acttttggat aactgaaagc tttgtttcat     3120

tgttttattt gcccctcaat tgccacaaac ttactgaagg gctagtttca tggttcccat     3180

tagagggtgc ttgttcgctg ctgttgacca gcccaagggt cgtgacccac aggtcggctg     3240

acccagaggg catccagcct ggtgtttttc tgacacatgg cccaggcttt gtggtctttc     3300

atgacattaa tctctgaaag atcagaatgt atcccccaaa ataccattag ctatctttga     3360

gggtctatta tgaatctgtc atccatgaat tgccataaac ctaagtttgc ctcacctcag     3420

gcccagacca tgttttcaaa gagcaactta gtaatgtata cagtagtcag tacattttat     3480

gaaatactct attttgctaa attaacctct tgcagatctc ctcaggtgat cttaaattct     3540

agtcttgaga aactttgtga gcagatctgt tttcagcttc tttatatacc tttcatggta     3600

agtaaccatg gcagtgagga tggcagagtt ttgttttttt tttttttaat gggccaatca     3660

tgttctgagt attatgaagt ttatcctttc attcatgatc aaaattgtta aagacatcac     3720

attttataaa tacactgtta aatccacttt gctgtaggtt atagtttacc tgttatataa     3780

ttcgtagtgc taattgtagt agaagcaaat caatttagga tgttggaacg aaaataatca     3840

caataactaa tacagctttt taattgtgaa aactacaatt aaaaattata attttaatac     3900

caaccataat attacactgt atttagaaca ggcttatgta aaatgccctc atttatctaa     3960

ataagttgat tttttggtta ttgtaatcta gtaaggtttt tgcatcacta ctggtctgtc     4020

atgaagtttt tctgctggct tattcactta tttagacttc atttagggaa gctatttcag     4080

aataccatct cataaaatgt atcattatct tgtttttgca aaattcactt actttttggg     4140

cacatttacc cagcatttca aataagtgta taggcatgtg ccttgtttaa gtacaattta     4200

taagacttca tgtttgcaag ttacatatta gggtagtgat tgtttatatt accagggatt     4260

ctacacttta ccaaaaaaaa ttgccataag attttcctgt tccattttaa attgtcttga     4320

tatttaaaaa aataacttct acattctcag gaagaaatac atgaagtaaa tcatatctcc     4380

atgtctgttt ccagatttct ctaatctttt tactatccca atacattcct aattcctata     4440

aacgtagtgg cttaaatact gaatacctgg cagctcttaa agatccctta ggcagatgat     4500

gataattttc agtgtttcgt catgtttaat agaaatcaaa ctgacttgtg ttttaaaata     4560

caagttgtct gctagtaaag ttacatgatt taggtgtgtt ttaggttttc tgcaacaatt     4620

agctgtgaac ccctaatgta gctaagttta tacaaatttt ataatcaaaa ttatttattt     4680

ttattttttt agagtatgtc aaaaacatat agtgtttgct ttgtgaaata catttgctta     4740

gagttataaa atatactgtg actcagaaat tgtaaagtca gtttgcgttg taaaaatgaa     4800

tactaccagc atgtcaaaag aaaaataatt tacatttgta atataaagta aaattgtatt     4860

taatatattt attgaatttt aaatttgcac taacttgaaa actttaaagg ttatactaat     4920

ttaatgatta atgtggaccc aaatacataa tttggccaaa aaagtcatta gaatgggtaa     4980

tggttttgtg tggttttcct tcaaaatgat aatattgaag caagaaccag cattttatat     5040

tgataatttt tttaatattt ctacccagtt gaggacagtg gaatataagt agatatattt     5100

aaaatatcta gatatttaaa aagaaagaaa aggttgttta tcccaatctg aattcattct     5160

cagcaacaag acagaaaagg tggtttgggt tttgctttta aacagtgtcc ccctgtcttt     5220

ttcaattttt cccttgaagc ctttctcttg ttcttcagag tacgcgctgc aggctatctg     5280

cagcatcaga atgcctgggc aggctgttga aagtatggat tcctgagccc aacccttaac     5340

ttaatgattc cctgtctctg gagatgcaac atagaaatct ctgtttttat taacaagcgc     5400

ctcaggcgat tcttaagcat actgaaattt gaaagcttct ggtctgaacc tcatgtattc     5460

acctagggct tttgctaggt gggataccat gccgaaaaat tgaattaatt gtatgttctt     5520

aaaattgttt ttcttctact ccgctgtcct cttccctcaa aatcactttt ctaaaagaac     5580

tctatgaaaa acttatttgt atcataccca aattgatata tttgtctgaa ctctgttaca     5640

taaaaattgg tatgattcat atgtggaatc agtttttgga ctgtgaccca tgcagtgttg     5700

ggggacaagg agttgcttca ggagttagtg cagtgcgcct ccaaggggca gtgagccatg     5760

gaggcgcctg ccttctcact gcagtcaatg cagccacact tgtgtatact gagtgctgct     5820

tcagatctca gtagataaaa taattccaca tttaaaatga ttctgctatt ttttataaag     5880

ggtttgaaag ccactactat aatgactttg tcacctaatt gattttctac taatttttac     5940

atattcagaa acttcgtgtt tttttggtgg acagaatatt ttggaggtct ccgtcgctgt     6000

ttagaatgtg gccacttggc tgtttcacag tttttaaagc tattttattg aatagtaaag     6060

cagtgaactt agcctttgtt ctttgtgttt ctaatttaag catatagtct atttaatttt     6120

tgatatgtaa atacacatca atacatatat atttacccat gtggccctgt gtagtcagtg     6180

catgaggctt gcatagccca gaaaggtaca ttccagggtt ctggggaaag aattttaaaa     6240

tgccatcctc taatacagac gtttataaaa cttaaatgaa atgattgggc ttaaccatat     6300

gcaagaaagt ctgcagaaaa taaatcacct agaaactata aatagaaatg tgctgctgag     6360

gctgggcacg gtggctcaca cctgtaatcc cagcacttgg ggggctaagg gaggcgtatc     6420

acctgaggtc aggagtttga gacaagcctg gtcaacatgg tgaaacgccg tctctactaa     6480

aaatacaaaa aaaattagcc aggtacattg gcacatgcct ttaatcccag ctaatcagga     6540

ggctgaggca cgagaattgc tcgaacccag gcggcagagc ttgcagtgag cggagatcac     6600

atgactgcac tccagcctgg gcaacagagc aagactccat ctcaaaaaaa aaaaggccgg     6660

gcgtggtggc tcacgcctgt aatcccagca ctttgggagg ctgaggcagg tggatcacga     6720

ggtcaggaga tcgagactat cctggctaac acggtgacac cccgcctcta ctaaaaatcc     6780

aaaaatttag ccgggcatgg tggcgggcac ctgtagtccc agctactcgg gaggctgagg     6840

caggagaatg gcgtgaaccc gggaggcaga gcttgcaggg aggcggagct tgcagcgagc     6900

cgagatagtg ccactgcagt ggggcctggg ccaaagagtg agactccatc tcaaaaaaaa     6960

aaaaaaagaa agaaatgtgt tgctggtatc agatatcaga ccaagaacac ttcagtctct     7020

ctaaggatgc cctgagctac ctcactgtta aaggacgaca tcaacacaga atgcactaaa     7080

caggaaataa gctgtaatct agagaatttc cattatgtgt tactttttgg tgactaacat     7140

ggaatgttga aaaggaagag ctggaaagct cagttgtttt ccttgttcct ctgacattgt     7200

ccaggcaaga gggcatcctg atcagatgag tagatttggc tgagaaaaac cctagagtaa     7260

ggcaggcact ttgtggaggt ggatgatgat ggctcataaa aacgtttgtt ctcagtccag     7320

ttcagggctc tgccagcagt ctttcagatc tgaactgctt aaacaaaccc tacagataaa     7380

ttggcactct gatttgtaat tctgtttgta caagtttaga gcagcctagc tcgagtcctc     7440

aaccccagtc ctcttagaag tgaactgatt gcactggatc cctaaaccca caatgttgag     7500

gacacatgtg atgactccac ttgctcagcc agctggcctc ttgcactttc ccctgcccac     7560

cacttgtaac taccacttaa ttatcttgtg ttaattgctt ttgttgtgtt gggtctgtat     7620

ttttgtggtc agtgcctgca ggcagaaatg tgaaagcatt tggtatgttg aagatacttg     7680

cttctttttt aataaaatta aaagtgcagc acgtaagtat gatactgtgt agttttttga     7740

cacaaccatg agatacaata agcagctttg acttagtgtc ccaaaaagtg gttcttggtc     7800

tacagcaggg caaacatata tgtggcaagt tctgatcaca tacttttaga cagaaagaat     7860

aaaaaattca tattgcatgg cttttgtagc ctaagagcac agaatcatac acgtgtgtta     7920

ggagaaacat tcattctcac gcatataaac tggctcctgg cagagtagag cagtaagtgg     7980

gatcaaaggt gaattcacct tattttcagt tggtagagta tggaaaaatg tatcacttat     8040

ttgaaatacc tgaatggaaa cccagcctct actactgtaa cttaacactt gttcttcctg     8100

agcctcaaat tttctttctc tgtaagaatg ggaattaatg cccacctacg ggttgcaagt     8160

gcttacagga gctgggcaag caacgaaggt aagagttgta gagacttcgg taaactggag     8220

cacatgattc ctgggaagca ggcctagtgt aaacaattta tttttctaga aaagacagaa     8280

gtttagagta tatgaaatct aatttttaag tattggttgg caactaattg actatcgtct     8340

accataaggt tatatgataa ttattagggc aggagagtga atgcatctta atatgcatgg     8400

cagaactgtg tgtttccttc catctggatt ttcataaagc tttctgattt atcagtaacg     8460

atctgaaaaa tgtactgtgg catgtaacat cttttattca ttttattagg cattagagga     8520

agaatattct gtagtcctgc tttattctgc catctttacc tggaaatcca tttttataaa     8580

atttttgtaa taaaaattca cttgatca                                        8608


<210>  22
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Glu Ala Glu Arg Arg Pro Ala Pro Gly Ser Pro Ser Glu Gly Leu 
1               5                   10                  15      


Phe Ala Asp Gly His Leu Ile Leu Trp Thr Leu Cys Ser Val Leu Leu 
            20                  25                  30          


Pro Val Phe Ile Thr Phe Trp Cys Ser Leu Gln Arg Ser Arg Arg Gln 
        35                  40                  45              


Leu His Arg Arg Asp Ile Phe Arg Lys Ser Lys His Gly Trp Arg Asp 
    50                  55                  60                  


Thr Asp Leu Phe Ser Gln Pro Thr Tyr Cys Cys Val Cys Ala Gln His 
65                  70                  75                  80  


Ile Leu Gln Gly Ala Phe Cys Asp Cys Cys Gly Leu Arg Val Asp Glu 
                85                  90                  95      


Gly Cys Leu Arg Lys Ala Asp Lys Arg Phe Gln Cys Lys Glu Ile Met 
            100                 105                 110         


Leu Lys Asn Asp Thr Lys Val Leu Asp Ala Met Pro His His Trp Ile 
        115                 120                 125             


Arg Gly Asn Val Pro Leu Cys Ser Tyr Cys Met Val Cys Lys Gln Gln 
    130                 135                 140                 


Cys Gly Cys Gln Pro Lys Leu Cys Asp Tyr Arg Cys Ile Trp Cys Gln 
145                 150                 155                 160 


Lys Thr Val His Asp Glu Cys Met Lys Asn Ser Leu Lys Asn Glu Lys 
                165                 170                 175     


Cys Asp Phe Gly Glu Phe Lys Asn Leu Ile Ile Pro Pro Ser Tyr Leu 
            180                 185                 190         


Thr Ser Ile Asn Gln Met Arg Lys Asp Lys Lys Thr Asp Tyr Glu Val 
        195                 200                 205             


Leu Ala Ser Lys Leu Gly Lys Gln Trp Thr Pro Leu Ile Ile Leu Ala 
    210                 215                 220                 


Asn Ser Arg Ser Gly Thr Asn Met Gly Glu Gly Leu Leu Gly Glu Phe 
225                 230                 235                 240 


Arg Ile Leu Leu Asn Pro Val Gln Val Phe Asp Val Thr Lys Thr Pro 
                245                 250                 255     


Pro Ile Lys Ala Leu Gln Leu Cys Thr Leu Leu Pro Tyr Tyr Ser Ala 
            260                 265                 270         


Arg Val Leu Val Cys Gly Gly Asp Gly Thr Val Gly Trp Val Leu Asp 
        275                 280                 285             


Ala Val Asp Asp Met Lys Ile Lys Gly Gln Glu Lys Tyr Ile Pro Gln 
    290                 295                 300                 


Val Ala Val Leu Pro Leu Gly Thr Gly Asn Asp Leu Ser Asn Thr Leu 
305                 310                 315                 320 


Gly Trp Gly Thr Gly Tyr Ala Gly Glu Ile Pro Val Ala Gln Val Leu 
                325                 330                 335     


Arg Asn Val Met Glu Ala Asp Gly Ile Lys Leu Asp Arg Trp Lys Val 
            340                 345                 350         


Gln Val Thr Asn Lys Gly Tyr Tyr Asn Leu Arg Lys Pro Lys Glu Phe 
        355                 360                 365             


Thr Met Asn Asn Tyr Phe Ser Val Gly Pro Asp Ala Leu Met Ala Leu 
    370                 375                 380                 


Asn Phe His Ala His Arg Glu Lys Ala Pro Ser Leu Phe Ser Ser Arg 
385                 390                 395                 400 


Ile Leu Asn Lys Ala Val Tyr Leu Phe Tyr Gly Thr Lys Asp Cys Leu 
                405                 410                 415     


Val Gln Glu Cys Lys Asp Leu Asn Lys Lys Val Glu Leu Glu Leu Asp 
            420                 425                 430         


Gly Glu Arg Val Ala Leu Pro Ser Leu Glu Gly Ile Ile Val Leu Asn 
        435                 440                 445             


Ile Gly Tyr Trp Gly Gly Gly Cys Arg Leu Trp Glu Gly Met Gly Asp 
    450                 455                 460                 


Glu Thr Tyr Pro Leu Ala Arg His Asp Asp Gly Leu Leu Glu Val Val 
465                 470                 475                 480 


Gly Val Tyr Gly Ser Phe His Cys Ala Gln Ile Gln Val Lys Leu Ala 
                485                 490                 495     


Asn Pro Phe Arg Ile Gly Gln Ala His Thr Val Arg Leu Ile Leu Lys 
            500                 505                 510         


Cys Ser Met Met Pro Met Gln Val Asp Gly Glu Pro Trp Ala Gln Gly 
        515                 520                 525             


Pro Cys Thr Val Thr Ile Thr His Lys Thr His Ala Met Met Leu Tyr 
    530                 535                 540                 


Phe Ser Gly Glu Gln Thr Asp Asp Asp Ile Ser Ser Thr Ser Asp Gln 
545                 550                 555                 560 


Glu Asp Ile Lys Ala Thr Glu 
                565         


<210>  23
<211>  17309
<212>  DNA
<213>  Homo sapiens

<400>  23
gcagcttgcc ctggagcgta gctggagtgc ggctgagttt tcgctccgct gaagccggag       60

tcggagagga tggcaggggc cggaggccag caccaccctc cgggcgccgc tggaggagcg      120

gccgccggag ccggcgccgc ggtcacctcc gccgctgcct cggcggggcc gggagaggat      180

tcgtctgaca gcgaagcgga gcaagaggga ccccagaaac tgatccgcaa agtgtctacc      240

tcggggcaga tccggaccaa gaccagtatt aaagagggac agctattgaa gcaaaccagt      300

tctttccaaa ggtggaaaaa gcgatacttc aaacttcgag gccgcaccct ttactatgca      360

aaggactcaa agtctctgat atttgatgaa gttgacctct cagatgctag tgtagctgaa      420

gcaagcacga aaaatgctaa caacagcttc acgatcatca ctccattcag aaggctaatg      480

ctgtgtgctg agaacagaaa ggagatggag gattggatca gctcactgaa gtctgtacag      540

accagagaac cctacgaggt ggcccagttt aatgtggaac atttctcagg gatgcacaac      600

tggtacgcct gctcccacgc ccgacccacc ttctgtaacg tgtgcagaga gagtctttct      660

ggagtcacct cccatggcct gtcctgcgaa gtgtgtaaat tcaaggctca caaaagatgt      720

gcagtgagag caacaaataa ctgtaaatgg actaccctgg cctccatcgg gaaggacatt      780

atagaagatg aagatggcgt cgcgatgcct caccagtggc ttgagggcaa cctgcctgta      840

agtgccaagt gtgctgtctg cgacaaaaca tgtggcagtg ttctccgtct acaggattgg      900

aaatgccttt ggtgtaagac aatggtacac actgcctgca aagatttata ccatccaata      960

tgtccacttg gtcaatgtaa agtatctatc atacctccaa ttgcactaaa cagcaccgat     1020

tccgatggtt tctgtagagc aacattttcg ttctgtgtta gtcctctatt ggtttttgtc     1080

aattctaaga gtggagataa tcagggagta aagttcctcc gtcgctttaa acagttgcta     1140

aatccggctc aggtgtttga tttaatgaat ggaggtcctc atttaggttt aagattattt     1200

cagaagtttg acaatttccg gattcttgtt tgtggaggcg atggaagtgt aggttgggtt     1260

ttgtcagaaa tcgataagct caacttgaat aaacagtgtc agctgggagt gttgcctttg     1320

ggtacaggaa atgaccttgc ccgagttctt ggctggggag gttcatatga cgatgacacc     1380

caacttcctc agatcctaga gaaactggaa cgagccagta ccaaaatgtt ggacaggtgg     1440

agtataatga catatgaact caaattgcca ccaaaagctt ccctacttcc aggacctcca     1500

gaagcatctg aagaatttta tatgacgatt tatgaagact cagttgcaac gcatcttaca     1560

aaaatcctca attctgatga acatgcagtg gtcatatctt ctgccaagac gctatgtgaa     1620

actgtaaagg acttcgttgc caaagtagaa aagacgtatg acaaaacctt ggaaaatgcc     1680

gttgtagctg atgccgtggc cagtaaatgt tcagtcctaa acgagaagct cgaacaactg     1740

ctgcaggctt tgcacacaga ttcccaggct gcgcctgttc tccctggcct cagccctctc     1800

attgtggaag aagatgctgt ggaatcgtcc agtgaagagt ccctgggtga aagcaaagag     1860

cagcttgggg atgacgttac aaaaccttcc tcccagaaag ccgtcaaacc aagggaaatc     1920

atgttgcggg caaatagttt aaagaaagca gtgaggcaag tcattgagga agccggaaaa     1980

gttatggatg acccgacagt tcacccctgt gaaccagcta atcagtcctc tgattatgac     2040

agcacagaaa cagatgaatc taaggaggaa gctaaagatg atggtgccaa agaatcaata     2100

actgttaaaa ctgcacctcg gtctccagat gcccgggcaa gttatggcca ttcccaaact     2160

gattctgtcc ctggtccagc tgtggcagcc agcaaagaaa acctccctgt gctcaatacc     2220

agaataatct gcccaggttt aagagcagga ctggctgcct caattgctgg gagttcgatt     2280

atcaacaaaa tgttactggc aaacattgat ccttttggtg ccacgccgtt tattgacccg     2340

gatctagatt ccgtagatgg atattcagaa aaatgtgtca tgaacaatta ctttgggatt     2400

ggattagatg caaaaatttc attagaattt aataataaaa gagaggagca ccctgaaaaa     2460

tgcaggagcc gaactaaaaa cttgatgtgg tatggagtcc ttggaacccg ggagttatta     2520

cagagatcgt acaagaattt agaacaaagg gttcaacttg agtgtgatgg gcagtatatt     2580

cctcttccca gcttgcaagg catagccgtg ttgaacattc ccagctatgc tggaggcact     2640

aacttttggg gtggaactaa agaggatgat atatttgctg caccatcctt tgatgacaag     2700

atcctggaag ttgtagcaat atttgatagc atgcaaatgg cagtttcaag ggtcattaaa     2760

ctgcagcatc atcgaatagc ccagtgccgt acagtgaaaa tcactatatt tggtgacgaa     2820

ggagtcccag tgcaagtgga tggtgaagcg tgggttcagc ctccagggat tatcaaaatt     2880

gtgcacaaaa acagagcaca aatgctaaca agggacagag cctttgagag cactctgaaa     2940

tcttgggaag ataagcagaa gtgtgattct ggtaaaccag ttctccgaac ccatttgtac     3000

atccatcacg ccattgactt ggcaacagaa gaggtgtcgc agatgcagct atgctcccag     3060

gctgcagagg agctcattac taggatatgt gacgcagcca caattcactg tcttttggag     3120

caagaactgg cccatgctgt gaatgcctgc tcccatgccc tgaataaagc caacccaagg     3180

tgcccggaga gtcttacaag agacactgcc actgaaatag ccatcaatgt gaaggcgctg     3240

tataatgaaa cagaatcttt gctagttggc agggttcctt tgcagctgga atcgccacat     3300

gaagagcgag tatccaatgc cttacactct gtggaggtgg aattacagaa actgacagag     3360

attccttggc tttattatat cttacaccca aatgaggatg aggaacctcc tatggattgc     3420

accaaaagga acaacagaag caccgtattt cgaatagtgc caaagtttaa aaaggaaaag     3480

gttcagaagc agaagacaag ttcacagcct ggatctgggg ataccgaaag tgggtcatgt     3540

gaagcgaatt ctccagggaa ttaaagagct tggaaggagc actccacagt cggaggtgta     3600

atcatattgg tgctatttct tggaagagaa gttattgcca cttaatacaa agtccttgga     3660

agcaagtggc tgttcttgta gttttctgca tagataagta agcaccactg aagcacctct     3720

gtggcttgat attttgctgt gggtgaaatt ttgatttgag gtattagaaa atatttttgt     3780

gccgaacaat acattccaca aagccatttt ctttttgtgc aaacctgaca tgttcaaata     3840

tattcacaat ggtaataagg taggaggaat ctgagacgat tgcattgtct aaacagtgga     3900

attgcaaaat gtttactttc catagatctg gtctgatgga atgttcctac tgtgcaactg     3960

cataacaata tgtggttaaa acttcctagg tttcattacg ggggggcatt ggccattttc     4020

ttaaaatcat aggttaggag actaaaatat aaattaagtt gtgatttgaa tgtagattgg     4080

tatcacctcc aactcctagt gcttagtggt caaatatgtt gaaaaccttt ccaatactat     4140

gaatgaatgc aaatcttaat gcacgatgtt cctgcctgaa atgtctttct ttttcttgca     4200

tgtcacatct aatactgtaa cactttaaat agctttcatg tcagttttaa tgttaatggg     4260

atttaattta ttactaaagt acatttttgt tggttaaggg cactgcactt ttctgttttt     4320

taatgtggga ttttgcgtaa atattctgta cctaagactt tgtgaaagtg tgtctgtgcc     4380

ataatcaaca aatgatatac atcacatgca agtcaatttt atttcaatct atcataagca     4440

gtaggcgtgc acgttaagaa aattctctgg atattttcat aaaattacat gctcccttac     4500

ctgacaaaac ttgttacagc tttccaaacc aaaatttcca cattttgttt ctaattttta     4560

atttcaattt aataattatt taatattcta tttgaattta taatatagta aagtgttgat     4620

atccaggaat tccctgaggt gtcaactgag atttatatac tgacagataa cccagactca     4680

cccgctctct acagtgactt ctgacacgat cttccaaaca gaagggattt aaattttttc     4740

ttaagggctt tatgttgtta ttattattat ctcacttaat tcttaattct tatcaggtgg     4800

atattatttt cctttttcta aaccactgta cttcagtgta gcttattatt agaagtcaac     4860

attacaatga tcaaatcttt gaaagccaaa ggcatacgta tcaaaaagtc acaaaaatat     4920

ccttaaataa gctttcttta gccattatat accaaaacat taattataat attttaaaat     4980

ttgtatataa gagaaataaa cagggtactg actcagtggt gacaattttt atgaagtagc     5040

ctgctaggtg cttaatagat atatatacac acagatatat acatatacac atatatgtgt     5100

atatatacat acatacacat atacatttat atgtgtatat atatacctac atacatataa     5160

ccttgtgata tggcatcatt gatattttct agacaattat ttccccagtg tttaaagaga     5220

aatactaata ggcgagcatt taaaatgaac tattgtcagg catattattt aattacatca     5280

aaggagttta actgtttgac actttactct tgtttataac ttgggtattt aactactagt     5340

aaaaatcaca aaattttaat gtctttaaaa taaatgaccc tgagggattc ctgaccaagt     5400

atgtctgact atatatttta cctaagttgt aaataaatgg aaattttcca aagacagtta     5460

tatcaagtag tttaaaaagt catgaggcag ggtgctgtgg ctcacgcctg taatcccagc     5520

acttcgggag gtttaggtgg gtagatcacc ggaggtcagg agttcgagac cagcctgacc     5580

agtgtatgaa accccatctc tactaaaaat acaaaaatta gccgggtgtg gtggcacgca     5640

cctgtaatcc cagctactcg ggaggctgag gcaggagaat tgcttgaacc caggagatgg     5700

aggttgcagt gactgagatc acaccactgc actctactag cctgggtgac agagcaagac     5760

tcccatctca atctcaaaaa aaaatagtca tgaattatgc aattattcta attgtatctg     5820

cacttacgaa gtcagaggtc tcctttttca gtccctctga tagtcccacc taagtgctgt     5880

cctgctcctg tgaacacttt cctgtgcaac caaacaggag gtgccaggtt cccagaactc     5940

tctaacatta cagatctctg tccatcttta ctaaaaaaag gaaatgtgag ggaaagaagg     6000

ggaagaactc tagcataaat aatgtattaa tataaatatc tatattgatt ttcacccccc     6060

attccccttt gctaatagaa aagagtctag ctatgatgtg tcccaaattt aagagtgtga     6120

tgtgaaggac tgaatttttg tttgttcgtt tggtgagctt ttcactcgta ggtgacatct     6180

tttgtatatg ctgtaaagtc tcagttaatg gaatcctaca gtgcatttct ggctagctcg     6240

gttggtagag cgtgagtctc ttaatggaat ccttaattag ctagaatttt cctgcaaatg     6300

gctttggatg agggaaattc tataaaatga caatttggat atactttttg ttaaatgaga     6360

gcaattttct ctgtatgctt tgtctatgca tggctgtgca gggcccaaat gacttcactg     6420

acacctgttt ccaggagggg gtcttcagag cctccttagg ctcttgtcag tatcataaat     6480

aattcctctt cttatagcgg atggggttac caaaaaaaat aaaaagtagg gaagagcttc     6540

tccatgggat cagatcacag ctttggggag tgggatgggg cctctatgct ttgatctatg     6600

catgagctgg ggtgagaagt tcccacctgc acctgactgc aatgactgta atggctggaa     6660

ttgtcacctc ttctccctga taggctcttc ctcacctgga ggatcggggc tggtgggagg     6720

gcagggaagg ggaggccatc agccagaatg tattttcttt cagttccatt tcctgaggaa     6780

gaacttgctt ttaaaggagg aaagggacag aatcagacct aaataaaatt cctgagtatg     6840

caatatttct ctttagtgtc tcttcacctc cctttctgag tttctttcct acatcctggc     6900

tcttcatttt cccaatgccc aatataatca tggttgctga aattctcact gccttctact     6960

ttcctttccc catcaattaa cccactacaa aatgacccct ttcatttctc gcttaagcat     7020

acatggtggg tcatttaact aagtgttagg aagaaaacaa tttaaagaca ctaattttac     7080

agtttgcgtt ctgtaaaagg atacttgctg gataatctaa gtgaattgat ggattaggtc     7140

atttgggatt gtgatatata ttgttcttgc tgacaagaaa tgacccatga atgtctagat     7200

ctatcctgtc caatattgta gctacatgtg gctatctaaa tttaaatgta atttaattaa     7260

gccaggcata atggcacaag cctgtaattc cggtgactca ggaggcttag gagggaagat     7320

ggcttcaggc caggagtttg agaccagcct cggcaacata gtgagaccct gtctctgaaa     7380

aaaaattttt ttaactagct aggcatggtg gcatgcgcct gtagtcccag ctattctgaa     7440

ggctgaggtg ggaggattgc ttgagaccag gagttcaagg ctgcagtgag ccatgatcat     7500

gctactgccc tccagcctgg gcagcagagc aagaccccta ctctttaaaa aaattaattt     7560

aattagaaac tccatttctc agttgcacta actacatttc aagtgttcag taaccatagt     7620

ggacagtgca gatgtagaaa atttccatca ctgcaaaaat tctattggac agcactggtg     7680

cagatcattg ctactcaaaa tgtgatccat gggccagcag catcaatatt acctgggagc     7740

ttacagaaat gcagaatttc aggcccactg cagatctacc gaatcaaaat cttcctttag     7800

caaaatttct caaacgatta gcactggcct acatccattt tatccttcct tagctattag     7860

ggatgtgagg tccgagggct tcaaaaggtc cccggaatag cttgttcctt catccactgt     7920

gtcctattca ttcttcagct aactccagca atgagctgaa actcattcat cacccttgct     7980

gagttttctt ctcaatcctt attcctaatt ctggttctag atgagcccta cctacccagt     8040

ggttgtattt ttgtagccag tgtgggacac aggagattgg cagaccaaca cagctagcct     8100

ctctctagcc ctccctccac ctctaagtca ctaacaatcc atgtttgttc agtttgttga     8160

catgtggcat gttcatttgt tcacaactta atcacggggg acatttcaga aaaatgtgta     8220

ctaagttaaa accatgttta gtctcctaca acttgtacat tttcattttc tcttatcagt     8280

agattgtcct tgttgacata gctcatgcat gaggacacat agcagtacac acacattgaa     8340

tgaattgtta gtcatgcaaa aaaagaaaag gaatgaacca agatgattgc aagttaatct     8400

catttaagcc ctctaaaaag gcatgctttg ctagatttag atctgttttc cttacactca     8460

cttatcttga tgttcacatg gttaataatt ccttaaaata gtgcctgaag aataatattt     8520

catattcttg acccccaaat aacagtttac ttaattttat aagatttttc ccaatgagac     8580

ttattttcag gaatccttct cttaataact tttacatatt gatataatgt accaaaacac     8640

aattgcctag agatgcttta gctaattttt attaataaag aggacaatat ttttgtcttc     8700

atggaactta tttttaacag gaatcaagga agaaaatatt catgcagagc tatgacttag     8760

aaagttatag gggctgccac tatacagcac ttctaaagta aaacatcttc tatctccaac     8820

tgggctgtca acatagtgga ctttcatgtt ctatggatat gaattcttta aggatgtagc     8880

ccttaattaa gctgtaaaaa caatgcatct ctcaaccttg acatttagga tctctcctgt     8940

ctgccccctc tacgccccac tccaattaac tcatcctaca tctctcagat gtaagttgga     9000

taagagtggg tttgaagttt ggtaatacaa gtggcagttt taaaacacca aattctttag     9060

atcagctgaa aagaagagtg agaattgaaa attcctccac tagtaattgt tagccaatag     9120

aatagcctcc cagagcagtc cccacagcac ttggttgcca tgggtttctc tcctctcact     9180

gcctgcccca gtgccatgat gtctggggct tgtctcttct atggcatccc ctgattgact     9240

tttgtatagc aacctctgtg tcaagtcagt aatatgatgc cattgtaata ggaggccttc     9300

ctaaagaagt aactgcaact tttaaaacgt gatgattatt ggtttttata atacacaaag     9360

cattaatttt ttcttatctt attttctctt tattatttct ttccaacttt tgtttggaga     9420

catttatgtt agaagaaaaa ctataaagtt ttatcattgt agagaacaga gagatcaaag     9480

acagctggac tgtacctgtt tgtgtaatta tttctgatat ttttaggaaa agaagtttaa     9540

cagagtaact cagactgaga ctgttaaact ctgttcatga taaactccat attacataat     9600

ataggtgaac agattaattc cctccatgta actaagatac tctatttaca ttatttatat     9660

actctcttag ttttttatgc acttccaagt tttagttgga aaaatgaaaa ccaagctact     9720

acttaaaagt tattaaaaac ttcacataaa atatttcatt ttagctacaa gttattcatt     9780

gcataggatt ttataaatag tctgggtatt tcataggaac tgcatttcaa aagtgaatta     9840

accaaaccta aaaaaagggt tacttttaaa atgcattaaa ataaagaagt ttcatattca     9900

gttgataagg ccattaaggt aggataatgc agttacatat acaaactaaa aaaggaaaaa     9960

gaatatattt tgtggtcctt aatgtttgat tgcactattg tttcccacag cttagccgta    10020

tctatttctg tataccaagt attaagctga tatgtagcta aatatttctt acagttctgg    10080

taactggtaa ctagtgctgt gaaaggtttt ggtattgtaa cattcccagt tttgtgagtt    10140

atatattgta tattgaagat gactagtaaa ttcaagtaat atatttatct acagctggga    10200

aaatataatt attttcaaat cttcaagtaa gttgtatcga atgtttttct tcctcttaag    10260

tgagataaat ctcactttta tgttaaaatg tctatttata caacaggttt ctccttttgc    10320

tgttattttc atattaaaat ttttcttatc tttttatatc aaaataatta tgctggctat    10380

tcaaactgcc aagatgtatt ttagtttgca ggatttttgg cagacaaaat atttaataac    10440

aaatataaaa gctttgtata ttttgtggca ttaggggcaa gaattttacc tttggatttc    10500

tctatgtgag gcagtgctgg tgtcagcaaa gtcagtaaca gacagtatta cttgtaatca    10560

tcaaaagaag gtttccacaa gttgtataaa tcagtgcatt tatttattat gttgtgaaac    10620

ttaagcttta tatgaaatac atattctagc tcttttcctt tttactgctg ttgtttagag    10680

tgtgtagttc tgttgatgat ttacttatgt acttgaagta ctcatttctg tcaaacagat    10740

gcccaactat tttcctttta aaaaactgta ttctttactg caatagatag cggaatagta    10800

atagacactt tgttaaaaaa ataagtttca tgtttaaaat aaatattttt ttaaaatata    10860

aagccaaaat gaattcacca atattaagga tttaatgtag ccaagggatt cagtgtgtta    10920

tattttgcca atatgtattt tatcttcatg tcacaactta ttttctgtag ccaattctca    10980

gttttagttg aagagagatc tcagtgattg tactgccaat atgacattca aatgaacatt    11040

aggaatcttg aaccatggct gagcgctgtt gctcaggcct gtaatcccag cactttggaa    11100

agccgaggga ggtagatcac ctgaggtcag gagtttgaga ccagcctggc caacttaata    11160

caaaaattag ccaggtgtgg tggtgggtgc ctgtaatccc agctactcag gaggctgagg    11220

caggagaatt gcttgaaccc aggaggtgga ggttgcagtg agccaagatc tcgccactgc    11280

actccagcct gggcgacaga gcgagactct gtctcagggg gaaaaaaaag aattttgaac    11340

cccccaaaat atcacatatc tagcagttct aggttccagg gtggatattt ttaacatatg    11400

tttgcatttg gttctgggat agtaaccgtt atggataatt gtttgtttct gtcaagtcgg    11460

tgagatttta attgtttgaa ttatttctat ttaaaattac tctcaattta actgtttaaa    11520

aaactaaaaa tttaaaacat aatggcacaa catacgacac agaataaaac acatgttttc    11580

aaggaagaag aaaaaactgt tttgacttaa tgtgaagcag gggtttacca aagaaaattg    11640

ctttaataag ccctaacttt aactgttttc ttctatgtta cagtgttagc ggttgatgta    11700

ttgtgtactg tttaagaact cataggagac taataattaa tttactataa ttttaaaggc    11760

aaagagtttt atattaattt tactgttgca caagcagtta ttggaagtgg gggaaaaaaa    11820

gaaaactggt gagagaaatt acatggaaat tataggaaaa aggaacttga attggtaatt    11880

tggcaaagat ttgggaacaa atagtttgaa catagatttc tttcacctta tatgatagaa    11940

acacaaggca cacgtgagct gtatagtgtg ctgagcacac ccccagaaaa caaaaaatat    12000

cacattgatg aagtccgaga ctgtatctag atcttagcat aactagtgaa ttcagggagc    12060

acatcctgct gctgaaattg agaagtcagt aagaaggtag ttcagatgac ctaatcattc    12120

aagacatttg atggagtcca cacaagggtt tatgatgtgg ggcaaatatc tgtgctttct    12180

catctcagtg attgatgtct ggagaactag tcagacacac ttagctggtt cctatagaaa    12240

aacaccagta aatgtggatc agaccatacc ctgcagacca aggagatttt cttaaacttg    12300

ctaagccttt cttaaacttg ccaagtatta gcaatgataa ttgctaaatg gattttttcc    12360

tttcactgaa acaacaaaac aattattgaa attcacaata cctagagatg ggaacatggt    12420

ttaggtttat ccagttctgt aactgacttt ggcattggct cattgtgtcc tttctacaag    12480

ttatgttttg gtgacttggt gtccccagtt agaaatggca cacaatatta tcagttgtta    12540

gtacttggta acgtttcttt tactaaagga attatataag tatgaatcat acctaatttt    12600

acaatttctt tcccacggtc attttggata taaagataga cttcccagac agtgaggtta    12660

gaaattagaa gttcaaattg atatccctga tgtttaattt aaaaatgaaa gtaaagttaa    12720

aattagtagc atttgtacca gagtagatta tgggtatttt catctgttat attacatgtt    12780

catattattc attttaggat aggccaaaac tcacttctaa aatcttcaaa aattttgaat    12840

agtttcattt tttcaatact taagccaaat gacaatttta tagatgtgaa tatatgtttt    12900

ttaaagttaa gtccttcata tcttttctta gtttaactcc ccaaagagga aaatgtctct    12960

ttaaaccagt agttaaaaag atggagtatg tgatgttcct ttctctgtac tgagttctga    13020

atgtttaatc cagagcatgg atcactgact gcgttctctg actgtggaat ggtattcttt    13080

catgcaaagt actttcaaaa cttcccataa agaaactaaa ctagagattg tctttattaa    13140

ttaatggaac tctgggtatg attaagggaa ttaaattaga aagtagaata acctagttaa    13200

aatcattata ttagttatac atgagagtca gtgaacgatg acttgatttt tacatgacat    13260

ttgaattctg tcactatctg attcttgacc taaaggtttc tttgctaaat ctgatattta    13320

ttatagtata atatgataat ttggagctcc tgttgcatct cactgcccca aaaatgttgg    13380

aatgccatat gatacaggga aaagattgga gttcatcacc gtggaatttt gatctgtctt    13440

aatgacacaa cttaattttc atgatgatag atctctgaat gattaatcca gaatgatttg    13500

gtacagtgac tggaagaaat tgtttttctg ggaatttgct tcccataatg acctgatata    13560

caggtgacct tagtataatt gaaattaatt ataattttaa ttagaacatg ctctgtttac    13620

agattataat tgcgcagcat tttaaaaaaa tatacataat tatgaggatg agagaattgc    13680

aaacttgaac agttcttttg ttttctctcc ttttacttga aaagctttca gaaagctttt    13740

gaaagatgac acagttttca tagcaacagt atgcaaatta ggtttttctg ccaagaaact    13800

cataaactaa agtatggaat aacacaaatg cttaatctta atcttggctt tggattttgt    13860

aagcaaaagc attttctgca tcaatttttt tcagtatgca gttgcatatt tcattttttg    13920

attatgtcaa aagttgaatt ctcattttat gctgtgtttc tcattagttg cagtaaagtg    13980

ttgatttcat tgctgccttt caggccttca tcatacaaac cctcaccatt tttcactcct    14040

gtgcttttgc cataggtttt tttttgtttt tggttttttt ccagcaacta gtttttctac    14100

tttcactctt tcccaccaga gtggtctctc taaaacaaat ttgctaaagt tcttaagtag    14160

gctctttttt ctctaaatta cagaatagca aactaactcc taagcaagat gagtcagtgt    14220

ctatgacctt gcctctttct tcctttttag tatcctcacc aaccttccct ctgttgactt    14280

ttgtaatcca ggaatttgga actacttatg acttagtgcc ttggcataat cacatgccat    14340

agatgaacat gttcaagact cagttcaaat ttaactttct gtgaagccct acctgacttc    14400

cctaggcagg tattttctcc atgcctatag tatattgaaa ctttttctgt taaaataaca    14460

taacatttca attacacaca cacaacctgt ctcttccact gaacttctct ctcccccttt    14520

gtattctcag tgtctagcta cacataatag gactttgata aatatttttg aatgaaggta    14580

atagaaaacc cgaacttctc tatatttgtg tactttcaca aacaaaggct tagaattcca    14640

catgaaagtc cacatgaggt aagtgtgcat tcatgagcat gtgtgcactc tgggcaaacc    14700

aacagaagat aaacagcaag gaagagcagt tgttttgtga aaaataatca tctgttagct    14760

gtaaatcaga aatattggcc aaatcagaat tcttgtttct aaaatgaggc ttctaaaatt    14820

ttcacataac tgccaaactc ttatttgtaa ttcttaaata tgccctaaag atcatctttc    14880

tcttttatag acatttagtg tatacagtcc acataaatac atatactgat tacctacaga    14940

caataatgag acttcagaaa gaatcaaaag caatagtgat ggtggaattt ttaaataata    15000

ttcagctggg gggaaataga ctgagtttgt gtgatttcag gttatttaga gttattaatg    15060

taaacataag aaggcttgtg actcttatca ccctctatag aatataaaga ctaaaaataa    15120

aaactattac ctctgggcct gtttttcttt gggattagat aaagcctttc taccatatca    15180

ccaaatactc ataaaggcta acacagaaag cttttccaag ttaataattt ctaaaattaa    15240

atatcagggc caggtgtggt ggctgacacc tgtaatccca gcactttggg aggccgaagt    15300

gggtggatta cctgaggtca ggagctcgag acaagtcaac atggtgaaac ctcatctctg    15360

ctaaaaatac aaaaactagc caggcatggt gatgcacacc tgtaatccca gctactcggg    15420

aggctgaggc aggagaattg cttgaaccca ggaggcggag gttgcagtga gctgagattg    15480

caccactgca ctccagcctg ggcgacagag tgagactctg tctcaaaaaa aagaaaaaaa    15540

atcaaaataa ttgtaattaa ctgaaatgcc ctgttccttc attcacttga tagacttttc    15600

tacctgctct atacttggca ctcaattaga ttctggggat acagataaaa taagacaaag    15660

ctcccatctg gtagagtcca agtttgtttt cacagttatt tttccacagt ctgtttaagg    15720

tattaggagg acttttataa accgagtgtt tttcaggtta cttcagagag gagtctcctt    15780

ccacccaaaa aaactaacca aattatttta tcataaagag gtaatcccat ttttatgtcc    15840

acaattttta catttttgta tcagccacca ataattttga ctgttttgtc aagtacatat    15900

ttcatcaatc ctatttccac agccgtacat gtgatcccag tgactgatag atctgtagaa    15960

tgtgaactca catttaaagt ttattttggg aaggcatata tgccttttga tgacacacac    16020

accaaaatat ataagagctg tgcatggtaa acccacagta gaagggaaaa agtaatgctt    16080

tctggtatac ttcagaggct ccatttgaag atgtgcgttg atgtttcctt gattattttg    16140

aatgaggagt aggcggtaat atttaacagg tagcatacgt atctaagcat atagtaaata    16200

ttactagtac ttgtgtgcca tgaggcacta atacataggt gaaacaaaaa tatttttagt    16260

tctaaaaaat tctctagata tttatggatg gttaggcaat agggttcctt catgagaagg    16320

aaaaaactgt atctttattg tcagtaagtg tggaaaaaaa cccgacttgt atgtgtattc    16380

acagtttgat aggcatattt tgaagtcatt gttttccatc agtattaagt atcatccatt    16440

tctatgttct ctagcaaaag aaaattctta gtgtgataca gctttactct ttgtttgact    16500

ttgtacaagg tccacaaaag gaggaggctc aaaagattgg acactttacc ctgacattca    16560

gcacattcat tttatctttc gataaagata accagaaatc atttgcctct tgtttattat    16620

catgttgaaa acacaacagt atagttcctt ttgtccctta cattggaaaa ggtattttaa    16680

atttagcctt gccgtattat ttatagttag gaatttacta cattttggta gtctgttttg    16740

aaactaagca cttgtgtctg aaagatgcag ataatatcta tctatttatt acacagtggg    16800

ctctgtttgc tgcagaaaag agtgaaactt ttaactgctt agcacacttg ccagtgaaat    16860

atacctgaca gagcagaggt tataactttg gctctaatta cttttagtaa tggtaagaca    16920

acgtgagttt tgtttgttta catgctgttt acaatggcat aattttaaaa atatatacaa    16980

ttgagatatt tattgcctac tattttaaag atgttttatg tgttttcacc tttggaatat    17040

attgttacat ttccttgtac agataatttt ggtggctttg ttaatgtagc tagtaatttt    17100

tatgactact aagtgaccag ttttcggtgc cttttattgt gggatgcatg attatgtatt    17160

tattgtacgg aagtcactga cgtgtgtatt tttgtacttt gctgaaagta atggttgatc    17220

ctgatgtaca tgatgatgaa agacatcttt cccaaagggc actgccttga gatcatcctt    17280

ctcaaataaa aagaatgcat ttgaagaaa                                      17309


<210>  24
<211>  1163
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Gly Ala Gly Gly Gln His His Pro Pro Gly Ala Ala Gly Gly 
1               5                   10                  15      


Ala Ala Ala Gly Ala Gly Ala Ala Val Thr Ser Ala Ala Ala Ser Ala 
            20                  25                  30          


Gly Pro Gly Glu Asp Ser Ser Asp Ser Glu Ala Glu Gln Glu Gly Pro 
        35                  40                  45              


Gln Lys Leu Ile Arg Lys Val Ser Thr Ser Gly Gln Ile Arg Thr Lys 
    50                  55                  60                  


Thr Ser Ile Lys Glu Gly Gln Leu Leu Lys Gln Thr Ser Phe Gln Arg 
65                  70                  75                  80  


Trp Lys Lys Arg Tyr Phe Lys Leu Arg Gly Arg Thr Leu Tyr Tyr Ala 
                85                  90                  95      


Lys Asp Ser Lys Ser Leu Ile Phe Asp Glu Val Asp Leu Ser Asp Ala 
            100                 105                 110         


Ser Val Ala Glu Ala Ser Thr Lys Asn Ala Asn Asn Ser Phe Thr Ile 
        115                 120                 125             


Ile Thr Pro Phe Arg Arg Leu Met Leu Cys Ala Glu Asn Arg Lys Glu 
    130                 135                 140                 


Met Glu Asp Trp Ile Ser Ser Leu Lys Ser Val Gln Thr Arg Glu Pro 
145                 150                 155                 160 


Tyr Glu Val Ala Gln Phe Asn Val Glu His Phe Ser Gly Met His Asn 
                165                 170                 175     


Trp Tyr Ala Cys Ser His Ala Arg Pro Thr Phe Cys Asn Val Cys Arg 
            180                 185                 190         


Glu Ser Leu Ser Gly Val Thr Ser His Gly Leu Ser Cys Glu Val Cys 
        195                 200                 205             


Lys Phe Lys Ala His Lys Arg Cys Ala Val Arg Ala Thr Asn Asn Cys 
    210                 215                 220                 


Lys Trp Thr Thr Leu Ala Ser Ile Gly Lys Asp Ile Ile Glu Asp Glu 
225                 230                 235                 240 


Asp Gly Val Ala Met Pro His Gln Trp Leu Glu Gly Asn Leu Pro Val 
                245                 250                 255     


Ser Ala Lys Cys Ala Val Cys Asp Lys Thr Cys Gly Ser Val Leu Arg 
            260                 265                 270         


Leu Gln Asp Trp Lys Cys Leu Trp Cys Lys Thr Met Val His Thr Ala 
        275                 280                 285             


Cys Lys Asp Leu Tyr His Pro Ile Cys Pro Leu Gly Gln Cys Lys Val 
    290                 295                 300                 


Ser Ile Ile Pro Pro Ile Ala Leu Asn Ser Thr Asp Ser Asp Gly Phe 
305                 310                 315                 320 


Cys Arg Ala Thr Phe Ser Phe Cys Val Ser Pro Leu Leu Val Phe Val 
                325                 330                 335     


Asn Ser Lys Ser Gly Asp Asn Gln Gly Val Lys Phe Leu Arg Arg Phe 
            340                 345                 350         


Lys Gln Leu Leu Asn Pro Ala Gln Val Phe Asp Leu Met Asn Gly Gly 
        355                 360                 365             


Pro His Leu Gly Leu Arg Leu Phe Gln Lys Phe Asp Asn Phe Arg Ile 
    370                 375                 380                 


Leu Val Cys Gly Gly Asp Gly Ser Val Gly Trp Val Leu Ser Glu Ile 
385                 390                 395                 400 


Asp Lys Leu Asn Leu Asn Lys Gln Cys Gln Leu Gly Val Leu Pro Leu 
                405                 410                 415     


Gly Thr Gly Asn Asp Leu Ala Arg Val Leu Gly Trp Gly Gly Ser Tyr 
            420                 425                 430         


Asp Asp Asp Thr Gln Leu Pro Gln Ile Leu Glu Lys Leu Glu Arg Ala 
        435                 440                 445             


Ser Thr Lys Met Leu Asp Arg Trp Ser Ile Met Thr Tyr Glu Leu Lys 
    450                 455                 460                 


Leu Pro Pro Lys Ala Ser Leu Leu Pro Gly Pro Pro Glu Ala Ser Glu 
465                 470                 475                 480 


Glu Phe Tyr Met Thr Ile Tyr Glu Asp Ser Val Ala Thr His Leu Thr 
                485                 490                 495     


Lys Ile Leu Asn Ser Asp Glu His Ala Val Val Ile Ser Ser Ala Lys 
            500                 505                 510         


Thr Leu Cys Glu Thr Val Lys Asp Phe Val Ala Lys Val Glu Lys Thr 
        515                 520                 525             


Tyr Asp Lys Thr Leu Glu Asn Ala Val Val Ala Asp Ala Val Ala Ser 
    530                 535                 540                 


Lys Cys Ser Val Leu Asn Glu Lys Leu Glu Gln Leu Leu Gln Ala Leu 
545                 550                 555                 560 


His Thr Asp Ser Gln Ala Ala Pro Val Leu Pro Gly Leu Ser Pro Leu 
                565                 570                 575     


Ile Val Glu Glu Asp Ala Val Glu Ser Ser Ser Glu Glu Ser Leu Gly 
            580                 585                 590         


Glu Ser Lys Glu Gln Leu Gly Asp Asp Val Thr Lys Pro Ser Ser Gln 
        595                 600                 605             


Lys Ala Val Lys Pro Arg Glu Ile Met Leu Arg Ala Asn Ser Leu Lys 
    610                 615                 620                 


Lys Ala Val Arg Gln Val Ile Glu Glu Ala Gly Lys Val Met Asp Asp 
625                 630                 635                 640 


Pro Thr Val His Pro Cys Glu Pro Ala Asn Gln Ser Ser Asp Tyr Asp 
                645                 650                 655     


Ser Thr Glu Thr Asp Glu Ser Lys Glu Glu Ala Lys Asp Asp Gly Ala 
            660                 665                 670         


Lys Glu Ser Ile Thr Val Lys Thr Ala Pro Arg Ser Pro Asp Ala Arg 
        675                 680                 685             


Ala Ser Tyr Gly His Ser Gln Thr Asp Ser Val Pro Gly Pro Ala Val 
    690                 695                 700                 


Ala Ala Ser Lys Glu Asn Leu Pro Val Leu Asn Thr Arg Ile Ile Cys 
705                 710                 715                 720 


Pro Gly Leu Arg Ala Gly Leu Ala Ala Ser Ile Ala Gly Ser Ser Ile 
                725                 730                 735     


Ile Asn Lys Met Leu Leu Ala Asn Ile Asp Pro Phe Gly Ala Thr Pro 
            740                 745                 750         


Phe Ile Asp Pro Asp Leu Asp Ser Val Asp Gly Tyr Ser Glu Lys Cys 
        755                 760                 765             


Val Met Asn Asn Tyr Phe Gly Ile Gly Leu Asp Ala Lys Ile Ser Leu 
    770                 775                 780                 


Glu Phe Asn Asn Lys Arg Glu Glu His Pro Glu Lys Cys Arg Ser Arg 
785                 790                 795                 800 


Thr Lys Asn Leu Met Trp Tyr Gly Val Leu Gly Thr Arg Glu Leu Leu 
                805                 810                 815     


Gln Arg Ser Tyr Lys Asn Leu Glu Gln Arg Val Gln Leu Glu Cys Asp 
            820                 825                 830         


Gly Gln Tyr Ile Pro Leu Pro Ser Leu Gln Gly Ile Ala Val Leu Asn 
        835                 840                 845             


Ile Pro Ser Tyr Ala Gly Gly Thr Asn Phe Trp Gly Gly Thr Lys Glu 
    850                 855                 860                 


Asp Asp Ile Phe Ala Ala Pro Ser Phe Asp Asp Lys Ile Leu Glu Val 
865                 870                 875                 880 


Val Ala Ile Phe Asp Ser Met Gln Met Ala Val Ser Arg Val Ile Lys 
                885                 890                 895     


Leu Gln His His Arg Ile Ala Gln Cys Arg Thr Val Lys Ile Thr Ile 
            900                 905                 910         


Phe Gly Asp Glu Gly Val Pro Val Gln Val Asp Gly Glu Ala Trp Val 
        915                 920                 925             


Gln Pro Pro Gly Ile Ile Lys Ile Val His Lys Asn Arg Ala Gln Met 
    930                 935                 940                 


Leu Thr Arg Asp Arg Ala Phe Glu Ser Thr Leu Lys Ser Trp Glu Asp 
945                 950                 955                 960 


Lys Gln Lys Cys Asp Ser Gly Lys Pro Val Leu Arg Thr His Leu Tyr 
                965                 970                 975     


Ile His His Ala Ile Asp Leu Ala Thr Glu Glu Val Ser Gln Met Gln 
            980                 985                 990         


Leu Cys Ser Gln Ala Ala Glu Glu  Leu Ile Thr Arg Ile  Cys Asp Ala 
        995                 1000                 1005             


Ala Thr  Ile His Cys Leu Leu  Glu Gln Glu Leu Ala  His Ala Val 
    1010                 1015                 1020             


Asn Ala  Cys Ser His Ala Leu  Asn Lys Ala Asn Pro  Arg Cys Pro 
    1025                 1030                 1035             


Glu Ser  Leu Thr Arg Asp Thr  Ala Thr Glu Ile Ala  Ile Asn Val 
    1040                 1045                 1050             


Lys Ala  Leu Tyr Asn Glu Thr  Glu Ser Leu Leu Val  Gly Arg Val 
    1055                 1060                 1065             


Pro Leu  Gln Leu Glu Ser Pro  His Glu Glu Arg Val  Ser Asn Ala 
    1070                 1075                 1080             


Leu His  Ser Val Glu Val Glu  Leu Gln Lys Leu Thr  Glu Ile Pro 
    1085                 1090                 1095             


Trp Leu  Tyr Tyr Ile Leu His  Pro Asn Glu Asp Glu  Glu Pro Pro 
    1100                 1105                 1110             


Met Asp  Cys Thr Lys Arg Asn  Asn Arg Ser Thr Val  Phe Arg Ile 
    1115                 1120                 1125             


Val Pro  Lys Phe Lys Lys Glu  Lys Val Gln Lys Gln  Lys Thr Ser 
    1130                 1135                 1140             


Ser Gln  Pro Gly Ser Gly Asp  Thr Glu Ser Gly Ser  Cys Glu Ala 
    1145                 1150                 1155             


Asn Ser  Pro Gly Asn 
    1160             


<210>  25
<211>  5727
<212>  DNA
<213>  Homo sapiens

<400>  25
gcagtgccgt agtagcgggc cacggagata gacagctttg gagctgctga actccgagca       60

cagggtgaag accccggcgc taccaaccac agcctggcag cctggtctcc gcggcaccca      120

ctggggctgc atccccctcc cccgagaggg ctgcgcaggc gggaagacgc ccagaggcca      180

gcttcggtcc cccttctgtc tctcggttcc tctttcctcc caagtaaggg aataaaccgc      240

gaagaaggag cgccccgggc caccgcgcaa ccaagtgttg cctggtgagg aagagccagg      300

acttctgaat ttaccttgaa tacagacagg aggatgttgc ctaaggaata gcagagatct      360

tgtctcatct tctgagaggt gcctgctgct gctgtataca cttgagtgct cccagaagtc      420

tcctgaaagg cttacatcgc aaacctgcaa tgagccaggc cctgggctgg gcctccactt      480

cagcctagtg aacaaaactc catcactgcc ctttagccac tcacataaag tttaaaaatg      540

ggtgaagaac ggtgggtctc cctcactcca gaagaatttg accaactcca gaaatattca      600

gaatattcct ccaagaagat aaaagatgcc ttgactgaat ttaatgaggg tgggagcctc      660

aaacaatatg acccacatga gccgattagc tatgatgtct tcaagctgtt catgagggcg      720

tacctggagg tggaccttcc ccagccactg agcactcacc tcttcctggc cttcagccag      780

aagcccagac acgagacctc tgaccacccg acggagggag ccagcaacag tgaggccaac      840

agcgcagata ctaatataca gaatgcagat aatgccacca aagcagacga ggcctgtgcc      900

cctgatactg aatcaaatat ggctgagaag caagcaccag ctgaagacca agtggctgcg      960

acccccctgg aaccccccgt ccctcggtct tcaagctcgg aatccccagt ggtatacctg     1020

aaggatgttg tgtgctacct gtccctgctg gagacgggga ggcctcagga taagctggag     1080

ttcatgtttc gcctctatga ttcagatgag aacggtctcc tggaccaagc ggagatggat     1140

tgcattgtca accaaatgct gcatattgcc cagtacctgg agtgggatcc cacagagctg     1200

aggcctatat tgaaggagat gctgcaaggg atggactacg accgggacgg ctttgtgtct     1260

ctacaggaat gggtccatgg agggatgacc accatcccat tgctggtcct cctggggatg     1320

gatgactctg gctccaaggg ggatgggcgg cacgcctgga ccatgaagca cttcaagaaa     1380

ccaacctact gcaacttctg ccatatcatg ctcatgggcg tccgcaagca aggcctgtgc     1440

tgcacttact gtaaatacac tgtccacgaa cgctgtgtgt ccagaaacat tcctggttgt     1500

gtcaaaacgt actcaaaagc caaaaggagt ggtgaggtga tgcagcacgc atgggtggaa     1560

gggaactcct ccgtcaagtg tgaccggtgc cacaaaagta tcaagtgcta ccagagtgtc     1620

accgcgcggc actgcgtgtg gtgccggatg acgtttcacc gcaaatgtga attatcaacg     1680

ttgtgtgacg gtggggaact cagagaccac atcttactgc ccacctccat atgccccatc     1740

acccgggaca ggccaggtga gaagtctgat ggctgcgtgt ccgccaaggg cgaacttgtc     1800

atgcagtata agatcatccc caccccgggt acccaccccc tgctggtctt ggtgaacccc     1860

aagagtggag ggagacaagg agaaaggttg aactttttcc gtgatactcc agacttccgt     1920

gttttggcct gtggtggaga tgggacagtt ggctggattt tggattgcat tgataaggcc     1980

aactttgcaa agcatccacc agtggctgtc ctgcctcttg gaacaggaaa tgaccttgcc     2040

cgttgtctcc gctggggagg aggttatgaa gggggcagct tgacaaaaat cctgaaagac     2100

attgagcaga gccccttggt gatgctggac cgctggcatc tggaagtcat ccccagagag     2160

gaagtggaaa acggggacca ggtcccatac agcatcatga acaactattt ctccattggt     2220

gtggacgctt ccattgcaca cagattccat gtgatgagag agaaacatcc tgaaaaattc     2280

aacagcagga tgaagaacaa gctgtggtac tttgaatttg gcacctcgga gacttttgca     2340

gcgacctgca agaaactcca cgaccacatt gagttggagt gtgatggggt tggggtggac     2400

ctgagcaaca tcttcctgga aggcattgcc attctcaaca ttcccagcat gtacggaggc     2460

accaatctct ggggagaaaa caagaagaac cgggctgtga tccgggaaag caggaagggt     2520

gtcactgacc ccaaagaact gaaattctgc gttcaagacc tcagtgacca gctccttgaa     2580

gtggtggggc tagaaggagc catggagatg gggcagatct acaccggcct gaagagtgca     2640

ggcaggaggc tggcccagtg cgcctctgtc accatcagga caaacaagct gctgccaatg     2700

caagtggatg gagaaccctg gatgcagcca tgttgcacga ttaaaattac tcacaagaac     2760

caagcgccca tgatgatggg gcctccccag aagagcagct tcttctcgtt gagaaggaag     2820

agccgttcaa aagactaaac agtgtgccaa acaccagcta aaccaagaga gaaagcaaga     2880

aactataatg cacactcaca cacaatttat gtgcacactc acacatgcac acacacacac     2940

acatacacac tcttctctaa ccagtggaag caaagccacc cttcgggaag aaaacgtcac     3000

cttgccatac attctgtttc aacagtgggt acacccctaa cagagccagt gccaacaaaa     3060

cattttgaat ggacttaggg cccatgaggt tgtggctggc ttaggcagca acctccacat     3120

tcccacaggc cttgagcaga attttctgag actgaaggga aatccccctt tctttctacc     3180

agccctgcaa gtttcctcat ggacgctcgc gaggagcagg ctgcaggttt cctgcctatg     3240

gtgagatcag atgtggccaa gggaaggagc tctggttcca gagaatttgc acaaagttcc     3300

ctctgtacag agacaaaacg gcctccggct ctcagagcat aatccttggc agggctcagc     3360

aggcgcacgt tggtttcttg gtcgtccttt gagtgacaac ttctccgtga acctgctgaa     3420

gaggcagaaa ggctgtggaa agctgtattt ccattcttgg gtttctgcgc cgtcggtggg     3480

cacttgttat tttccaggaa ccttctcctg gtgtctacat gtttgcttag aggcggctcc     3540

aagagccccc agagctgcct gcatagcaca ccttagatgt ggtatttatt ttcttagttc     3600

tgtgaacacc tgggagggag agcggagaaa ctgggattta tttttcaaat tggtgtcata     3660

atattgtgta aaaagggaag gaaaaaaaaa accaccccca gcttctttct ttttcaagcc     3720

aaagcgtgtt tcctgtttga gttccaagcc ctggtggcag actattcctg aaggcagaaa     3780

agatgggaag gaaggaactt tgctggggaa accaggagac ggttccctcc tgcttctttg     3840

cactcaccac tcccagagta tgacctgaag gaccttctga tggtcttaac gtgtgtgcgc     3900

gcgtgtgtgt gtgtgtgtgc gtgtatatat atatatttag cctatatatt tatatatata     3960

tatatataaa tatttattta ctgatggact tttcctcatt ggaaaaaaaa aacataggta     4020

gtatgagaca gaaagtggta aggaaaaaga aggttctcac tcccccactc caccgtttca     4080

ttgtcaggac gcatctccct gtggtgatca caagggttaa ggggaatgaa agtagctccc     4140

tattatgaac gaagagaccg agaactccta ttctggatcc tcaaaacaag catgaaagac     4200

ctgctgggct ggatttactc tcccatttgt cagataagaa aattgagtct cagaaaagtt     4260

cagagacttt tccatggtgt cttggctaat gcagcttgag agtaggtgcc gttacaaaga     4320

tatttaatgg agaaaagaac ccacacatct cagagtaggg tcatttctgg tcactgaaaa     4380

gtgagtccac ttggatccag gttgccaggg aggaacaaac gtacagcaca tgcgtggatg     4440

ggatatcccc acacaagaaa acgagcgcct catgctgctt cccagaggtt ctctctgacc     4500

tgaatggaaa agaagttggt ctgagatcga aggtactaaa cagatcatca gactgaactc     4560

tccacatgtc acctcatcat ggtcatcata gtctcttagt ttggaaacaa ccttggctgc     4620

agggatgacc tcagtggaga gtcacaagaa ggactgaggc gtcttctgca agatactgcc     4680

agccaggaca gaggggtctc agcagagctc agtgggcttc attcagcaag tgccagcatt     4740

accatccttt cccaagggca aggccatgca gagcttcatt gggcctccat ccctctctga     4800

gatttatcag tggaaacttg gacccacttg atatcgttcc actgagctgc ctctaatctt     4860

gcattggaca ggagctttgg acaaagaagg gaatattaag attgtgtgta caaatggcac     4920

ttaactgtga aggaccacct aggagcaaga tcttggacca ttctgctcaa cctaacagtg     4980

cagaatgcta agtaagggga aaaccaggcc acctgaagaa tatctttaat gatggtattc     5040

ttggtgatgg gaccaacaag ctccagaatt actacaggta ctatcttgga agccacttgt     5100

ttctgaaact gaggcaggtt caggtttggg gtcactgatt ctaagacatt tacagaagtt     5160

cgtgcatgtg tttcagccat gatccccaag attgaggcta ttgagacatg gcactatcaa     5220

caggtgaaat tgattctcag agactcacag gtctcatgaa ggggcagtgc agaaaatggc     5280

ccttacctgc tgcaccctag tgcacaggac ttgcaatgtt gcttgagaga catatcccaa     5340

gtccttctta gaggcatgga gtataacaac ttcagtggaa ttgcacttcc agtttggtaa     5400

ccttagtaaa tcttgtgttg ttgtttaatc gtgccttgca aatcatcctt taaacactat     5460

gactgtggtt tcttgtggtg gagtccctca tcatagtgac cctcatagca acctctgagg     5520

ttagcagaga aggtattatt atctcgatct caatgaggag aacaaggctt aatgaggttt     5580

agtgacttct caaagccaca tggttagtca ggggagaacc taatccctta tttcttatct     5640

tattctgatt ctggccatgc tacaaacatg ttctcacctg ccccccatgc ttctacccca     5700

acagcaataa aaactgtaaa gcaggaa                                         5727


<210>  26
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Glu Glu Arg Trp Val Ser Leu Thr Pro Glu Glu Phe Asp Gln 
1               5                   10                  15      


Leu Gln Lys Tyr Ser Glu Tyr Ser Ser Lys Lys Ile Lys Asp Ala Leu 
            20                  25                  30          


Thr Glu Phe Asn Glu Gly Gly Ser Leu Lys Gln Tyr Asp Pro His Glu 
        35                  40                  45              


Pro Ile Ser Tyr Asp Val Phe Lys Leu Phe Met Arg Ala Tyr Leu Glu 
    50                  55                  60                  


Val Asp Leu Pro Gln Pro Leu Ser Thr His Leu Phe Leu Ala Phe Ser 
65                  70                  75                  80  


Gln Lys Pro Arg His Glu Thr Ser Asp His Pro Thr Glu Gly Ala Ser 
                85                  90                  95      


Asn Ser Glu Ala Asn Ser Ala Asp Thr Asn Ile Gln Asn Ala Asp Asn 
            100                 105                 110         


Ala Thr Lys Ala Asp Glu Ala Cys Ala Pro Asp Thr Glu Ser Asn Met 
        115                 120                 125             


Ala Glu Lys Gln Ala Pro Ala Glu Asp Gln Val Ala Ala Thr Pro Leu 
    130                 135                 140                 


Glu Pro Pro Val Pro Arg Ser Ser Ser Ser Glu Ser Pro Val Val Tyr 
145                 150                 155                 160 


Leu Lys Asp Val Val Cys Tyr Leu Ser Leu Leu Glu Thr Gly Arg Pro 
                165                 170                 175     


Gln Asp Lys Leu Glu Phe Met Phe Arg Leu Tyr Asp Ser Asp Glu Asn 
            180                 185                 190         


Gly Leu Leu Asp Gln Ala Glu Met Asp Cys Ile Val Asn Gln Met Leu 
        195                 200                 205             


His Ile Ala Gln Tyr Leu Glu Trp Asp Pro Thr Glu Leu Arg Pro Ile 
    210                 215                 220                 


Leu Lys Glu Met Leu Gln Gly Met Asp Tyr Asp Arg Asp Gly Phe Val 
225                 230                 235                 240 


Ser Leu Gln Glu Trp Val His Gly Gly Met Thr Thr Ile Pro Leu Leu 
                245                 250                 255     


Val Leu Leu Gly Met Asp Asp Ser Gly Ser Lys Gly Asp Gly Arg His 
            260                 265                 270         


Ala Trp Thr Met Lys His Phe Lys Lys Pro Thr Tyr Cys Asn Phe Cys 
        275                 280                 285             


His Ile Met Leu Met Gly Val Arg Lys Gln Gly Leu Cys Cys Thr Tyr 
    290                 295                 300                 


Cys Lys Tyr Thr Val His Glu Arg Cys Val Ser Arg Asn Ile Pro Gly 
305                 310                 315                 320 


Cys Val Lys Thr Tyr Ser Lys Ala Lys Arg Ser Gly Glu Val Met Gln 
                325                 330                 335     


His Ala Trp Val Glu Gly Asn Ser Ser Val Lys Cys Asp Arg Cys His 
            340                 345                 350         


Lys Ser Ile Lys Cys Tyr Gln Ser Val Thr Ala Arg His Cys Val Trp 
        355                 360                 365             


Cys Arg Met Thr Phe His Arg Lys Cys Glu Leu Ser Thr Leu Cys Asp 
    370                 375                 380                 


Gly Gly Glu Leu Arg Asp His Ile Leu Leu Pro Thr Ser Ile Cys Pro 
385                 390                 395                 400 


Ile Thr Arg Asp Arg Pro Gly Glu Lys Ser Asp Gly Cys Val Ser Ala 
                405                 410                 415     


Lys Gly Glu Leu Val Met Gln Tyr Lys Ile Ile Pro Thr Pro Gly Thr 
            420                 425                 430         


His Pro Leu Leu Val Leu Val Asn Pro Lys Ser Gly Gly Arg Gln Gly 
        435                 440                 445             


Glu Arg Leu Asn Phe Phe Arg Asp Thr Pro Asp Phe Arg Val Leu Ala 
    450                 455                 460                 


Cys Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Asp Cys Ile Asp Lys 
465                 470                 475                 480 


Ala Asn Phe Ala Lys His Pro Pro Val Ala Val Leu Pro Leu Gly Thr 
                485                 490                 495     


Gly Asn Asp Leu Ala Arg Cys Leu Arg Trp Gly Gly Gly Tyr Glu Gly 
            500                 505                 510         


Gly Ser Leu Thr Lys Ile Leu Lys Asp Ile Glu Gln Ser Pro Leu Val 
        515                 520                 525             


Met Leu Asp Arg Trp His Leu Glu Val Ile Pro Arg Glu Glu Val Glu 
    530                 535                 540                 


Asn Gly Asp Gln Val Pro Tyr Ser Ile Met Asn Asn Tyr Phe Ser Ile 
545                 550                 555                 560 


Gly Val Asp Ala Ser Ile Ala His Arg Phe His Val Met Arg Glu Lys 
                565                 570                 575     


His Pro Glu Lys Phe Asn Ser Arg Met Lys Asn Lys Leu Trp Tyr Phe 
            580                 585                 590         


Glu Phe Gly Thr Ser Glu Thr Phe Ala Ala Thr Cys Lys Lys Leu His 
        595                 600                 605             


Asp His Ile Glu Leu Glu Cys Asp Gly Val Gly Val Asp Leu Ser Asn 
    610                 615                 620                 


Ile Phe Leu Glu Gly Ile Ala Ile Leu Asn Ile Pro Ser Met Tyr Gly 
625                 630                 635                 640 


Gly Thr Asn Leu Trp Gly Glu Asn Lys Lys Asn Arg Ala Val Ile Arg 
                645                 650                 655     


Glu Ser Arg Lys Gly Val Thr Asp Pro Lys Glu Leu Lys Phe Cys Val 
            660                 665                 670         


Gln Asp Leu Ser Asp Gln Leu Leu Glu Val Val Gly Leu Glu Gly Ala 
        675                 680                 685             


Met Glu Met Gly Gln Ile Tyr Thr Gly Leu Lys Ser Ala Gly Arg Arg 
    690                 695                 700                 


Leu Ala Gln Cys Ala Ser Val Thr Ile Arg Thr Asn Lys Leu Leu Pro 
705                 710                 715                 720 


Met Gln Val Asp Gly Glu Pro Trp Met Gln Pro Cys Cys Thr Ile Lys 
                725                 730                 735     


Ile Thr His Lys Asn Gln Ala Pro Met Met Met Gly Pro Pro Gln Lys 
            740                 745                 750         


Ser Ser Phe Phe Ser Leu Arg Arg Lys Ser Arg Ser Lys Asp 
        755                 760                 765     


<210>  27
<211>  13469
<212>  DNA
<213>  Homo sapiens

<400>  27
ggtgcgggcc ggcgcgggag ggcgcgggag gcggggagcg gcggcctctg attggccggg       60

gcgggggagt gagcggagtt tcccacaatg ccccggtgcg gtgcagccgc ggatggatgc      120

tgcgggaagg ggctgccatt tgctgcccct gccagcggcg cgcggacctg cccgcgctcc      180

tgcagccgcc gccgccgccg ccgccagccc gcccggcccc tgcagcggcg ccgcctgcgc      240

tccctccgcg gccgccggag cgggcgccat gaaccccagc tcctcggcgg gagaggagaa      300

aggggcgacg ggcggcagca gcagcagcgg aagcggcgcc gggagctgct gcctgggcgc      360

cgagggcggc gcggacccgc ggggcgcagg gtcagccgcg gcggcggggg ccgctgccct      420

ggacgagccc gcggccgccg gccagaagga gaaggacgaa gcgctggagg agaagctgag      480

gaacttaact ttccggaagc aggtctcgta caggaaagca atctcccggg caggcctcca      540

gcatctggct cctgcacatc ccctcagcct tcctgtggca aatggtccag ccaaggagcc      600

cagagcgact ttggactgga gtgagaatgc cgtgaatgga gaacacctgt ggctggagac      660

caacgtctcg ggagacctct gctaccttgg agaggagaac tgccaagtca gatttgcaaa      720

atcagctctc aggaggaagt gtgcagtctg taaaatcgtc gtccacaccg cctgcattga      780

gcagctagaa aagattaatt tcagatgtaa accaacattt cgagaaggag gctcaaggtc      840

accaagagaa aattttgtac gtcatcactg ggtgcacagg cgtcggcagg aggggaaatg      900

taagcagtgt ggtaagggct tccagcaaaa gttctccttc cacagtaaag agattgtggc      960

tatcagctgt tcctggtgca agcaggcgtt tcacaataag gtgacctgct tcatgctgca     1020

tcacattgaa gaaccctgct ccctgggggc tcatgctgct gttattgtcc cgcccacttg     1080

gatcattaag gtgaagaaac ctcagaactc cctgaaggct tcaaatcgga agaagaagag     1140

aacaagcttt aaaagaaaag ccagtaaaag agggatggaa caggaaaaca aaggtcgtcc     1200

ttttgtgata aaacccatct cttctcctct catgaaaccc ttgcttgtat ttgtgaatcc     1260

caagagtgga ggcaaccagg gaaccaaagt cctgcagatg ttcatgtggt acctgaatcc     1320

acggcaagtc tttgatcttt ctcaggaagg gccaaaagat gcgcttgaat tgtataggaa     1380

agtaccaaat ctgcgaattc tggcctgtgg tggggatgga acggtgggct ggatcctttc     1440

catcctggat gaactgcagc tgagccctca gcctcctgtg ggggtccttc ctctggggac     1500

tgggaatgac ctggctcgaa ctctcaactg gggagggggc tacactgatg aacctgtttc     1560

taagatcctg tgtcaagtgg aagatgggac agttgtacag ctagatcgct ggaacctcca     1620

tgtggaaaga aaccccgact tgcctccaga agaacttgaa gatggcgtat gtaagctccc     1680

tctgaatgtt ttcaataact acttcagcct tggatttgat gcccatgtca cactggagtt     1740

ccatgaatcc agagaagcaa atccagagaa attcaacagt cgttttcgaa ataaaatgtt     1800

ctatgcaggg gcagcttttt ctgacttcct acagagaagt tctagagatc tatccaaaca     1860

tgttaaagtt gtttgtgatg gaacagatct caccccaaag attcaggaac tgaagttcca     1920

gtgtatagta tttttaaata tacccagata ttgtgctggc acaatgccct ggggaaaccc     1980

aggtgatcac catgatttcg aacctcagcg tcatgatgat ggttatattg aagtcattgg     2040

atttaccatg gcctctttgg cagccctgca agttgggggc catggagaga ggctacacca     2100

gtgtcgagaa gtcatgcttc taacttacaa atccatcccc atgcaagtgg atggggagcc     2160

ctgtaggttg gccccagcta tgattcggat ctccctgagg aatcaggcca acatggtaca     2220

gaagagcaag aggagaacat ccatgccttt actcaatgat ccccagtctg tcccagatcg     2280

tctgaggatc cgggtgaaca aaatcagttt acaagactat gaaggattcc actatgacaa     2340

ggagaaactc cgagaagctt cgatacctct gggtattcta gttgtgcgtg gagactgtga     2400

tttggagact tgccgtatgt acatagaccg cctacaggag gacctacagt cagtttcttc     2460

tggctcccag agagttcatt accaggacca tgaaacctcc ttccccaggg ctctctcagc     2520

acagaggctc tctcctcggt ggtgcttcct agatgcaact tctgctgatc gcttttatcg     2580

aatagacaga tctcaggaac atttgcactt tgtgatggag atttcccaag atgagatttt     2640

tattctggac ccagatatgg tggtgtcaca gccggcgggg acacctccgg gcatgcctga     2700

cctggtggtg gaacaagcct cggggatctc agactggtgg aatcctgccc tgcggaaacg     2760

catgctgagt gacagtgggc tggggatgat agctccctat tatgaggact cagatctgaa     2820

agatctcagc cactcccgcg tgctacagtc accagtctct tcagaagatc atgcaatttt     2880

gcaggcagta atagctggtg atcttatgaa gctaatagaa agctataaaa atggaggcag     2940

tctgctaatt cagggaccag accactgttc actccttcac tacgcagcta aaaccggcaa     3000

cggggagatt gtgaaatata tccttgacca cggaccttcc gagttattgg atatggcaga     3060

cagtgaaacg ggtgagactg cactgcacaa ggctgcctgc cagcggaacc gggctgtgtg     3120

ccagcttctg gtggatgcag gagcatctct gagaaagacg gactccaagg gtaagacacc     3180

tcaagaaaga gcacagcagg ctggggaccc agacttggct gcttacctag aaagccgtca     3240

gaactataag gtcattggcc atgaggacct ggaaactgct gtttgaccct ggtattcggg     3300

caaagaggac atgagcaagc gtatcacatc tgccctccct gcaattgggc agctcccctg     3360

gaagaagctg atggaattca tatatctgtc tctctcctgc aagaatctac ctgagaccat     3420

gccactagct tttaagggct accaagatgt acaacagaac atgatagccc attgagaagg     3480

aggcaggata cctggagatt tgtggaatac agtacgagtt ccacaaaatt tgatccttat     3540

tgcttccagc aagtagcatg aacttctgtg ttcacctgta taatttattt taaagattca     3600

aaggatgttc gtataaatgg cactgctcca tcctccccct atgcattggt ttttttccct     3660

gtaccataca attctactgt aactacccat caacttaaag aaaaatatta tctcttctct     3720

ttacattcag tcttggaaga ccacaagatt gtctgaaggc cttctaaaac cttctgaatg     3780

tcctgcagaa atataactgt aaaaccactt ccatttctaa gactaaatat atcaagacta     3840

tttagtgact ctctctgcat gtccccctca cccgccaacc ctccgtttca ttatatagga     3900

gctgggaagt gccacatgga taatgtcaac ttgtgtgcta tatctctgag gaatggtgag     3960

gtggcatggg agatgtctgt gcttggaggt acctcagaga ggtaacccag gggtcagccc     4020

aggctgctgg gctgtagcca atagccatgc aggactggtt cagcttgggc tgtctgtaca     4080

gctccgtact gcctatgtgt agccatcttt gccttttgct gcaatagaag atgagcaaag     4140

gattaaacag aggcccacag ctagtttgca gaaccactca attttaagtg ctgtttaaat     4200

tgcagagcaa ataatcctgt gtgggaactg tggttacagg aaatggagca ctctaacaat     4260

gtttacttct aaactttgtt gaatgataat agaaagcacc ctaattgact tggaaaaaaa     4320

aaacagcaaa agcaaaagta gcaacatatg tcaacatatg tcactgaaat aggaaacagt     4380

cattggaatg ttgcacagag gctaataact atagactgtt ggatacagtg gtgagaggag     4440

ccccatttta ggtctttctt ttaggttttt ggttttcatt actccaagta atccttgacc     4500

caagaacaaa ggcttgttgt atgagttcca ctgccagatt tatgggatgc ctggatcatt     4560

cagaaggatg cttcaactat tatttgtcag gtccaaaggt cgtacttaat aaccccattt     4620

tctatgtatg gggtagtcta atatattatt ttatctactt tatttttccc ttttcagaaa     4680

gtccttagtg caaaccacca ttggaatcta gccagaaatg tctgtcagat agttagaatt     4740

gtaacatcta aacctgccac ggatcgaatg gtacttacag gtacctctct tagggactct     4800

gtgatcccta aaatatcaga agaaaatgtc tgtctttctg tccaaatatc tacttgactt     4860

gggggtaagt caaaaataaa agtaggtgtc caaggatttt acttttggcg aaatctgacg     4920

tctcctgagc ttattttcat tttgtccttg gacatagcat agtgcttccc taatgtttct     4980

acatatgacc atgaatgata gtgtctctac atttaattta aaagtctaat ggtgacattt     5040

tgcttatctg agtcacattt cggtaacata tcatcatttt gaaagtgcgg ctatgacgtg     5100

ctatattaaa caggaacagc ctttcagtgg atggggattt tattaccaca gtctttccat     5160

agtcatttca aaatcaaatt gttggtggga ggatggattg ggttgtgagt aatctacttc     5220

catatatcag cctcagaaat ggaactatcc tttggatatt acaggagaca ctgcagcaga     5280

ttgtttccag aagctggaaa aatatgctcc aggagaattt aatcactggg cttttgctgg     5340

gggattttta gttggcggga ctgtcaagga aatgtgatga cagaaatata atccttaaca     5400

caaactggaa tctggctttg aatggcatct tccattccct ggattgagtc aaatgtttgg     5460

ccaagcagtc agttatctag ctgttactgt tgggatgaag aactctgttt tcatcaacta     5520

ccatctcaca tttctctaaa tacttccaag tagcccagag aaaatttagg gtacaggtgg     5580

ctatgggcca atttctaaat agctccaatt gaagacataa atctgtgtta tgaaaaatga     5640

tgagttggta ctgtaagatt cctgatgcat ttggaaattt tttcaaacca aaaaaaaaaa     5700

aggcattaga gtcctgtgtt attcatggag accaatattt gatatatcgc tttgaaaaaa     5760

gcaagtacca ctaggacttg ggatttccaa aataaagtga gcagaataac cacatgttta     5820

atggcttcaa cattaaacca cctcctgtag catgttttaa aaattggtcc tgggctttgg     5880

aaagagctaa ggccttatgg tctaggagtt tccatctcag cttaagtata ttgtatccct     5940

actattagga catcaggaaa gcaagtgatc tagtcctggt ctgaagtgcc atgtaacttt     6000

aacagacata aaaatatgta cctatagaaa tatcatttct acaaagccta ctgagacagc     6060

actgaagagg cagctagctt ggctgactcc tctgtgtttg tttctttgtg tcatggcact     6120

gactgctttg agattccatt tttagatgtg gttgatagag gaatggaaaa tgaagagtta     6180

ttaaaagaca acattctgta acctgaaagg tagtcatttt tgcaagctta tattttaata     6240

ttgtgcattt aacaaaatag aacacagtta aactgtgctt tatcgtattc aaggacttca     6300

taaagaataa gagagaagat tagtaagcca agaatggaat aaataccatg actaggaatt     6360

ttgctttcag agcttatgtt tcctctgtag atgtgataac caaaaaccag tgcaagtttt     6420

gaaacataat ttagctggca aatgcacagt gatggaaatt agtaatgact gatggagagc     6480

cgtacatacc tgttgctcct tatcctttca gaatggctgc tttggcagat ctgcctgtgc     6540

tgggagctac tcaacatcac ttcattttca tctggaccta gtgagagtcc ctttgcctaa     6600

cgaatttctg aaatttattt atttactaga ccccttataa tattcatggc tttaaaaaat     6660

gacacagcat ctttatttta ttacatgtca attttattaa taatatttag gggttttttt     6720

aaattataaa aatggcacat gctttttata aaatgtttta ataccacaga tgagtatcac     6780

atccacagtc aaggcatccc tttgttctgg tgttgtgtcc cacttcccaa aaataaatac     6840

ggttaacact gatgaacact gttgcttgta tgtgatgtca gaaatacccc atccgttcat     6900

gcacaagtat gtatgtatat acgcatatac atttacacac atatatagac atttatttat     6960

atacacatgc aagtatgtat actatattca tgtatattgc ataggtttag aaaagagcaa     7020

acattttaaa agcatgctga tcatttgtat atgtctagtg aacaccagta ggcaaagaca     7080

ggttaaacag agaagttcca tttatttttt tgtttccacc attgctaggc ttagatctgt     7140

tatggcatta ctacaattgc acttagcatt ttctattacc tgtgtcataa aattcatgac     7200

caagagttcc tgtaattgtt tatgttgcct tccatgaagc atgaaaccta ccatagcccc     7260

aagacttatc tatgctatgt ttgtatttca agtaaaggag agttctttcc tctgtgatgc     7320

ttacaccact ttacaaggct gtttgtaaca ctaacactca gtaggttgcc tagtgatatt     7380

taattagggc aggctacttc cgggaaggtg taacttcagt gtagtatggg ggtctgagca     7440

gcttgtcttc cttccagaag gagtagctaa tgaaatcact gagaacagca tattttattc     7500

aattatgcta tttaaaaatg ggactttgtt aaaatggctc atcataacca tcaaataaaa     7560

ctactaattg ttctatttaa atgaattata ttcattttag gaaaagaagt agaaaaacat     7620

ctaataaatt agctttctga ttaatcttta acacttattt aatataaaat ggcttctgcc     7680

tgcatcttaa ttgaaccacc tttgaatctc tcaactcctt tcactctgaa tctcatactc     7740

agctgattag aagtcctaca ggtccttctc tgccaggtct gtcagatcga cttggaccct     7800

acccttttct gtgtccccag tcatccatta tctcttgtct ctctaagttt tgggccatag     7860

cggcagtcct gtccctgaac tttctgccta ctactgtcaa taattttgtc acgcagttgc     7920

aaaaatcttc cccagatatt atgctcaaaa tacatcaaaa tgaaattacc ctctgggaca     7980

agtatacctt ttactcaaag gacacatgga tgtccactga ccttgatcat cttatagaat     8040

tatggcaagc atgattctga aaatctatca ggtttagcaa atatctgtct tagtcccatg     8100

agggtacaca atcacggctg ctgcttcctc attcaacaat gtaagccaca tgcctctttg     8160

acggcacctg gaggactagg ttatagattt tacactgctg agggccatct ttggttttac     8220

actgtctcct cacagcttaa tgagaaacct gaaaataaga accaagaaaa gagtcatgcc     8280

cttggacaac ctcctctccc aggacactga gatttactga ccaggtccca gaaagaaagc     8340

agaaaaataa ttcttaggct cttgtagcat ggattttaaa atagaaacgt gaaaattgaa     8400

tggtatcttc ataatgcata gactccagag tctatttaca tatgtattca gttatgcatg     8460

taatcatatg tccatgaatc aatcataagt gcatgtattt aatcattatt tgaaaaatat     8520

ttgtcactct gaggcaggca tcatactaag gatataacaa tgaatgtaat agacaaaact     8580

cttgatttca tgaagctggc atctagaaga aaagacaaat tccaatgtga taagtgcagt     8640

gcaggagaac cccagggtgt ccagcatggg ctggaaattc aaccaaggct ttattgtacc     8700

agccactcat tagccagcaa tgttttggtt caatgaaaac ataagtagga agagaataat     8760

attttgcatt tccattttac tggagtcata gtagatttct aaaaatgtat ctgaaactaa     8820

gattttaaaa caagacttag aaacactatt aaaatgaaag ctaagactga tttattctag     8880

ctctcaggat agaactagga aaaataagca gagttttcag tgggttttga ctaaatataa     8940

agaagatgaa gtacaaataa tatgtaatag tggagtggat atcacagtta taaactttca     9000

gcctctgtta gcatttaaac agaggatacc tgaccactct gaggggtgtt gtgattagga     9060

atatgtgatt tgagggggct aaaattagat gctgtgattt ttcaaaagat attttttaat     9120

ggctttgttg aatggcagga ttttatttta aaaactcatg aaaatcttga tttttgattt     9180

gttaaacttt gctttataac tgagaatttt aaaaatatct aggggaatgg ccgttagtta     9240

tcatttaaaa aattttaaac taagcatgaa tttaagagct agtcaaaaga aaacatacta     9300

aaaggtgtaa tttaattaaa aatacttctg gaagcttata aattttgatc agtattctta     9360

gtcattgtca agtaaaattc tattagaaat ctgtcttact gtccatccaa tataaaaaag     9420

tgctgtggtt tgatattcta agagttaagt gtaatctagt ataaccacag aagaaaattc     9480

tgcctgtaag gtatttggga gccaagtaaa tgtacatgaa aggcaatcat ggaaaactct     9540

ttggcttctg ccaccagcgt ggcaaccaca agggaggtcc tacccatgga aataagaaaa     9600

tagtgatcca agttttcacc caacttttga aatttcaata ttttgagcca aatgccttct     9660

gaaatgggag gctttgatag tgggaaatac tgaaattatc ttttccctca gacctttagt     9720

gaaacacaca tatagttttc actctatgac agtataaaca actcaaatct atactgtttg     9780

ttaagaacag tttcaagaat taaaaagtgc tttagcgtta tgatgtattg acatgtttga     9840

gcttcagttg gggttcaaaa caaccccaac gaggtgaata atgcatataa tacattttag     9900

atgaatgcac tgaatctcag agcagtgaat tcagcctgtg cagattcata tagcaaatga     9960

tagtgctgca gccagaactg ggtctttaga aattacatat taacatgttt tctaagtaag    10020

tcattttcca tcattgcctt caaggatgtt ttatatcaat tgttcagatt tccataatat    10080

agaagttgcc tccatgaaaa aaaaatgttt acctaagttt ccacggaaag aatgagttag    10140

aaataaggga gaatgtgaaa tcaaaaagtc agagtttttg ctgtcggaga gaggcttgtc    10200

agcttgtaca tagttcaagc aaagaaaagt ctaatgtttg cataccaggg tggatttcaa    10260

gagaagaaat taacagtgag cgttaatggc ttctttaact tatttgtgat tctcagcatt    10320

taaaaaatgt tagtcctatt tttcttcctt tgaagtcact attaggatga tataatttct    10380

gaatgctgca acaaaaaatg ttaaaaatgg ccctgacatc caagactcta ttgctctaag    10440

tttatgggtg ggtatgcaag ctaagtgtta tgataataca tagtcatata catagaggtt    10500

taatacacct atgggaaatt ccggcatatt tgaagtagag aaaaacaaac aggcttgaaa    10560

tgtccttcag ttcagaatct catactttac aagggacatt tatgggcaga ttggtgaata    10620

tgtagaagga ggatgtttga tctggaaaga agacaaaatt ggattaggaa taagaatatg    10680

tagaggagtt aggttaagta ggactgttag tttcaaattc tgcagggaag atgatttgta    10740

gaataaaata aggaaagaaa agagcagtaa cacatgaaaa ggagttagct ttattactta    10800

taaggattta tttttcctaa acattgcatc cagaaaaaca gtttgggctt tctgaaaaac    10860

agtgaagttg ttatcactgt ttcttctagt agttaagtga agattgaaca actaactcag    10920

agatcaaagg catatcttta attgtgagag atcttggact agaaaaactc tgtgagattt    10980

tcttggttta aatgtctata attttagact ggaacagaac tcaatttgag cctatttttt    11040

tcccccaggt tcctgccaac tagatagcaa tgaaggcatt ttttaaaaaa gcttccatca    11100

ttgcaaatat atcccaaatc acttagcagc ggggatttca tgaccctaaa aagttgcctt    11160

gcttacacaa acacacctat gctttagtag aaacatatct tttttaggag atttgggaat    11220

tggctagcat ttttgccaat tgttagccaa tttaggagat ttggaaattg gctagcaatt    11280

ttgccaattg ttagccaatt cccaaatctc ctaaaaaaga tatgtttcta ctaaagcaaa    11340

aaggtcacag attcaggagt caaagtgaaa acaaaggatt tagtgttctt tcccctactt    11400

actacccatt tgttgtttgg gatgtagagt caggactgga gaagagggtg ggaaattcta    11460

tatcctctgc caatacagag gcatggaggc actttctata actttgtgtc atgaaacaag    11520

acttaacccc atatcagtag actaatgttt ctgtcatatt tctgtctagg tggattacag    11580

ttttaattgc ccatcatccc ttaattctgt aatacagctt gagttcctag atttcaggtt    11640

gactgggtga gggaggaagt cacttgaggt aattttaaga aatgaatcca tatccagagt    11700

cttgcagaaa agacctgctt ctactccacc ttctttcttg ttctacttct tgcctctggt    11760

ttgggggcat aaaagagggg cagagttgtg aggaaaggaa aaaagattct caaaagtagt    11820

acaataagaa gaccctagta gtaacacaaa ttctcatggt aatctcaaac aactgatagt    11880

gttagcagat attgaaaatc aaactcagga aacatacaga aagattaaat ttgttcaaag    11940

tggcttcaag gggtattagt tgtgaaaatt tcagtttatg cagcatagaa gaattagatt    12000

gtgtgtggaa cttgggggaa gtagggtcag ctaatagaag aactttttaa tggagctttc    12060

caaaggacga ggtggttttt ggaaggagtt tgtccaacct cttataatac attatgcctg    12120

tccacaaact tgttctggtc cctgataaag tttgaaaaaa ataaggaata tttagggttt    12180

tttcccacaa atctcaatat attcacttaa aaattcagag actgtgacct tgttattttg    12240

ggtttaaata tacattttcc tcttaaaaat gatagatata tgtttacaaa ttgtctttac    12300

tcttcactta taaaacacac acatacagat aggatagtcc tgtcagttta ccctattttt    12360

tgtttcaaat ttataggtaa tttcaaattt ataggtgttg gtgagattta tcacttttaa    12420

gataccatct agccttgata tttgttgtac cttctatatg caaccaaatg gctcctgatc    12480

tcctgatctt ctggagatca aagaattttt attcgccact ctccccaccc atcattggtt    12540

ggattgagac tctaattaca tacaagcata atttccaatg caagtagaac tttgatgctc    12600

tccctgactt accgattata agttgggaaa gtttggattc ttgccatcct ggggaaggag    12660

atttagaact ctcatagaca aaatattcta acacaacaga atattttgca aaacacatct    12720

ttgaaaagtc aggggccaaa atagtctcag caaaggttag cttggctgtt ttttaaaatt    12780

accaatagtt aagtgggcaa ccatgaatct gaatattata cagaccacca ctgactgaaa    12840

ctgaggaaaa ccattcttgt gaaaaactaa ggaatagagg acaatctcag ttctaaaaga    12900

atgaatatat ttgatttaat ttgatttctg agtgggaaaa cgttcccagg catccagggt    12960

acccttggct gtgggtattc cactcgcaaa ggctacatct gtatgaagag ttgcagtcac    13020

attataaagg gctttttcat gatttctgat tctgccctat cacatcccag agccatgctt    13080

ttgcaaagct gccagctggc aggtggaatc cataaacaag tagcagctgt ggcagtagaa    13140

agattaaagt tttatttcca ggtaaaggag gattcagata atacgaagtg gagggagggt    13200

gggtgggggg gggggggtgg gatgggaaag ggaagaatga agttttttgt aacaaagtca    13260

taaagtattt ttccctaatt ttcttgcatt tcctatttat ataaagtatc ttgatcactg    13320

tgttgcacta cagagatttt caatggagtt aatttgggag actgaactaa tctctgaaaa    13380

agaaattgac tagttacagt tactttttgg acactttttc tgtattgtga attgtgtgga    13440

aatgtacaga ataaaaatga agaaatgta                                      13469


<210>  28
<211>  1057
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Asp Ala Ala Gly Arg Gly Cys His Leu Leu Pro Leu Pro Ala Ala 
1               5                   10                  15      


Arg Gly Pro Ala Arg Ala Pro Ala Ala Ala Ala Ala Ala Ala Ala Ser 
            20                  25                  30          


Pro Pro Gly Pro Cys Ser Gly Ala Ala Cys Ala Pro Ser Ala Ala Ala 
        35                  40                  45              


Gly Ala Gly Ala Met Asn Pro Ser Ser Ser Ala Gly Glu Glu Lys Gly 
    50                  55                  60                  


Ala Thr Gly Gly Ser Ser Ser Ser Gly Ser Gly Ala Gly Ser Cys Cys 
65                  70                  75                  80  


Leu Gly Ala Glu Gly Gly Ala Asp Pro Arg Gly Ala Gly Ser Ala Ala 
                85                  90                  95      


Ala Ala Gly Ala Ala Ala Leu Asp Glu Pro Ala Ala Ala Gly Gln Lys 
            100                 105                 110         


Glu Lys Asp Glu Ala Leu Glu Glu Lys Leu Arg Asn Leu Thr Phe Arg 
        115                 120                 125             


Lys Gln Val Ser Tyr Arg Lys Ala Ile Ser Arg Ala Gly Leu Gln His 
    130                 135                 140                 


Leu Ala Pro Ala His Pro Leu Ser Leu Pro Val Ala Asn Gly Pro Ala 
145                 150                 155                 160 


Lys Glu Pro Arg Ala Thr Leu Asp Trp Ser Glu Asn Ala Val Asn Gly 
                165                 170                 175     


Glu His Leu Trp Leu Glu Thr Asn Val Ser Gly Asp Leu Cys Tyr Leu 
            180                 185                 190         


Gly Glu Glu Asn Cys Gln Val Arg Phe Ala Lys Ser Ala Leu Arg Arg 
        195                 200                 205             


Lys Cys Ala Val Cys Lys Ile Val Val His Thr Ala Cys Ile Glu Gln 
    210                 215                 220                 


Leu Glu Lys Ile Asn Phe Arg Cys Lys Pro Thr Phe Arg Glu Gly Gly 
225                 230                 235                 240 


Ser Arg Ser Pro Arg Glu Asn Phe Val Arg His His Trp Val His Arg 
                245                 250                 255     


Arg Arg Gln Glu Gly Lys Cys Lys Gln Cys Gly Lys Gly Phe Gln Gln 
            260                 265                 270         


Lys Phe Ser Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys Ser Trp 
        275                 280                 285             


Cys Lys Gln Ala Phe His Asn Lys Val Thr Cys Phe Met Leu His His 
    290                 295                 300                 


Ile Glu Glu Pro Cys Ser Leu Gly Ala His Ala Ala Val Ile Val Pro 
305                 310                 315                 320 


Pro Thr Trp Ile Ile Lys Val Lys Lys Pro Gln Asn Ser Leu Lys Ala 
                325                 330                 335     


Ser Asn Arg Lys Lys Lys Arg Thr Ser Phe Lys Arg Lys Ala Ser Lys 
            340                 345                 350         


Arg Gly Met Glu Gln Glu Asn Lys Gly Arg Pro Phe Val Ile Lys Pro 
        355                 360                 365             


Ile Ser Ser Pro Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys 
    370                 375                 380                 


Ser Gly Gly Asn Gln Gly Thr Lys Val Leu Gln Met Phe Met Trp Tyr 
385                 390                 395                 400 


Leu Asn Pro Arg Gln Val Phe Asp Leu Ser Gln Glu Gly Pro Lys Asp 
                405                 410                 415     


Ala Leu Glu Leu Tyr Arg Lys Val Pro Asn Leu Arg Ile Leu Ala Cys 
            420                 425                 430         


Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Ser Ile Leu Asp Glu Leu 
        435                 440                 445             


Gln Leu Ser Pro Gln Pro Pro Val Gly Val Leu Pro Leu Gly Thr Gly 
    450                 455                 460                 


Asn Asp Leu Ala Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu 
465                 470                 475                 480 


Pro Val Ser Lys Ile Leu Cys Gln Val Glu Asp Gly Thr Val Val Gln 
                485                 490                 495     


Leu Asp Arg Trp Asn Leu His Val Glu Arg Asn Pro Asp Leu Pro Pro 
            500                 505                 510         


Glu Glu Leu Glu Asp Gly Val Cys Lys Leu Pro Leu Asn Val Phe Asn 
        515                 520                 525             


Asn Tyr Phe Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe His 
    530                 535                 540                 


Glu Ser Arg Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg Asn 
545                 550                 555                 560 


Lys Met Phe Tyr Ala Gly Ala Ala Phe Ser Asp Phe Leu Gln Arg Ser 
                565                 570                 575     


Ser Arg Asp Leu Ser Lys His Val Lys Val Val Cys Asp Gly Thr Asp 
            580                 585                 590         


Leu Thr Pro Lys Ile Gln Glu Leu Lys Phe Gln Cys Ile Val Phe Leu 
        595                 600                 605             


Asn Ile Pro Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly Asn Pro Gly 
    610                 615                 620                 


Asp His His Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Ile Glu 
625                 630                 635                 640 


Val Ile Gly Phe Thr Met Ala Ser Leu Ala Ala Leu Gln Val Gly Gly 
                645                 650                 655     


His Gly Glu Arg Leu His Gln Cys Arg Glu Val Met Leu Leu Thr Tyr 
            660                 665                 670         


Lys Ser Ile Pro Met Gln Val Asp Gly Glu Pro Cys Arg Leu Ala Pro 
        675                 680                 685             


Ala Met Ile Arg Ile Ser Leu Arg Asn Gln Ala Asn Met Val Gln Lys 
    690                 695                 700                 


Ser Lys Arg Arg Thr Ser Met Pro Leu Leu Asn Asp Pro Gln Ser Val 
705                 710                 715                 720 


Pro Asp Arg Leu Arg Ile Arg Val Asn Lys Ile Ser Leu Gln Asp Tyr 
                725                 730                 735     


Glu Gly Phe His Tyr Asp Lys Glu Lys Leu Arg Glu Ala Ser Ile Pro 
            740                 745                 750         


Leu Gly Ile Leu Val Val Arg Gly Asp Cys Asp Leu Glu Thr Cys Arg 
        755                 760                 765             


Met Tyr Ile Asp Arg Leu Gln Glu Asp Leu Gln Ser Val Ser Ser Gly 
    770                 775                 780                 


Ser Gln Arg Val His Tyr Gln Asp His Glu Thr Ser Phe Pro Arg Ala 
785                 790                 795                 800 


Leu Ser Ala Gln Arg Leu Ser Pro Arg Trp Cys Phe Leu Asp Ala Thr 
                805                 810                 815     


Ser Ala Asp Arg Phe Tyr Arg Ile Asp Arg Ser Gln Glu His Leu His 
            820                 825                 830         


Phe Val Met Glu Ile Ser Gln Asp Glu Ile Phe Ile Leu Asp Pro Asp 
        835                 840                 845             


Met Val Val Ser Gln Pro Ala Gly Thr Pro Pro Gly Met Pro Asp Leu 
    850                 855                 860                 


Val Val Glu Gln Ala Ser Gly Ile Ser Asp Trp Trp Asn Pro Ala Leu 
865                 870                 875                 880 


Arg Lys Arg Met Leu Ser Asp Ser Gly Leu Gly Met Ile Ala Pro Tyr 
                885                 890                 895     


Tyr Glu Asp Ser Asp Leu Lys Asp Leu Ser His Ser Arg Val Leu Gln 
            900                 905                 910         


Ser Pro Val Ser Ser Glu Asp His Ala Ile Leu Gln Ala Val Ile Ala 
        915                 920                 925             


Gly Asp Leu Met Lys Leu Ile Glu Ser Tyr Lys Asn Gly Gly Ser Leu 
    930                 935                 940                 


Leu Ile Gln Gly Pro Asp His Cys Ser Leu Leu His Tyr Ala Ala Lys 
945                 950                 955                 960 


Thr Gly Asn Gly Glu Ile Val Lys Tyr Ile Leu Asp His Gly Pro Ser 
                965                 970                 975     


Glu Leu Leu Asp Met Ala Asp Ser Glu Thr Gly Glu Thr Ala Leu His 
            980                 985                 990         


Lys Ala Ala Cys Gln Arg Asn Arg  Ala Val Cys Gln Leu  Leu Val Asp 
        995                 1000                 1005             


Ala Gly  Ala Ser Leu Arg Lys  Thr Asp Ser Lys Gly  Lys Thr Pro 
    1010                 1015                 1020             


Gln Glu  Arg Ala Gln Gln Ala  Gly Asp Pro Asp Leu  Ala Ala Tyr 
    1025                 1030                 1035             


Leu Glu  Ser Arg Gln Asn Tyr  Lys Val Ile Gly His  Glu Asp Leu 
    1040                 1045                 1050             


Glu Thr  Ala Val 
    1055         


<210>  29
<211>  7494
<212>  DNA
<213>  Homo sapiens

<400>  29
agagccaagc cagccatgga gtgggatggg ggaaagtttg gcaccctgcg aggggctgcc       60

ggactggagt gggcggggcg cccgagggta ctttagcctt ccaggcttag ggactcaggc      120

tgcccagacc tgaagcggtg tgcggccatg gaccgcggag ctgccgcagc ccagggcact      180

gccccgcctc aggatggaga gcagcccgct gagtctccag agcctccgcc gccttggccg      240

ccgccgccac caccaccggc tccgccgccg gctccgccgc tgctctccga ggcttcgcca      300

gaacccatac cagagccctg tccagagctt gctccaggtc cctgtccaga ggcgacctca      360

gaatcagcca cagaactgta cacagaaccg accccagaac cagccacaga gccggcctca      420

gaaccggccc cagaacctgc cacagagccg gccccagaac ctgccacaga gccggcccca      480

gaaccggccc cagaacctgc cacagagtct gccccagagc cgactccaga acctgcccta      540

gagtcggtcc cagagccggc cccagagctg actccagaag ttgccccaga gctggcccca      600

gagccgaccc cagaacctgt gacagagctg gccccagagt tctgccctga ggcggctcca      660

gagttccgtc caagtccagc accatgtcta ttgcaatgtc cggtggacac tcgagagaga      720

ggtctaaaga cctcgccatc gccatcgcca tcgccatcgc ccagaacgcc aatgtcgtgg      780

tccagaataa agaaaatatt gaaggaagga cctatgctga agaactgtaa ctctttcaag      840

agatggaagc ttagatattt tctggttcaa ggacagaagc tctactttgc acaccatccc      900

gcgtttgcac actttgaaac gattgatctg tctcaagcca ctgtggcaga aagcagctgt      960

agaaaccttt gccacagttt ttgtgttatt acaccacaac gaaaaatcac tctggctgca     1020

cccaaccgga aagacatgga agaatggatt aacatcataa aaaccatcca acagggagaa     1080

atttataaga tacctgcagc agaaaacaac ccttttcttg ttggaatgca ttgttggtac     1140

tccagttaca gccaccggac ccagcactgc aatgtttgtc gagagagcat tcctgcctta     1200

tctagagatg ccatcatctg tgaagtgtgc aaagtgaaat ctcacagatt gtgtgctttg     1260

agagcaagca aagactgcaa gtggaataca ttgtctatca ctgatgacct ccttctgcct     1320

gcagatgaag taaacatgcc ccatcaatgg gtagaaggaa acatgcctgt cagctctcag     1380

tgtgcagtgt gtcatgagag ctgtggcagt tatcaaagac ttcaagactt ccgctgcctg     1440

tggtgtaatt ctacggtgca tgatgactgt aggagacggt tttccaagga atgttgcttc     1500

agaagccatc gctcatcagt cattcctccc actgctctaa gcgaccccaa aggcgatggc     1560

caattagtag tatcttcaga cttctggaat cttgattggt catcagcctg ttcatgtccc     1620

ttgctcatct tcatcaactc caaaagtggc gatcatcagg ggatcgtctt cctccgaaaa     1680

ttcaagcaat accttaaccc atctcaagtg ttcgacttat tgaagggtgg acctgaagca     1740

gggctgtcta tgttcaagaa ctttgctcgc tttcgcattc tggtttgtgg tggagatggc     1800

agcgtgagct gggtcttatc tctgattgat gcctttggat tacatgaaaa gtgtcagttg     1860

gcagtcatcc cacttggaac cggcaatgat ctggctcgtg ttctgggctg gggtgcattc     1920

tggaacaaaa gcaagtcacc tctggacatc ctcaacagag tggagcaggc tagtgtgagg     1980

atcctagaca gatggagtgt gatgattcgt gagactccca gacaaacccc gctgctaaaa     2040

ggacaggttg aaatggatgt accacgattt gaggctgctg ccatccaaca cttagaatct     2100

gcagccaccg agttgaacaa aatcctgaag gccaagtacc ccacagagat gatcatcgca     2160

accagattct tgtgttcagc tgtggaagat tttgtggttg atattgtaaa ggcctggggt     2220

cagataaaac agaacaacac tgcaatagtg tctgtgattt tgaaaagtga cttaatgtat     2280

gataggctca gtgtcctgat cgatgtcctg gctgaggagg cagcagctac ttctgctgaa     2340

aaaagtgcta cagaatatgc agacagcagc aaggcagata ggaagccctt cattcctcaa     2400

atagaccaca tagccaagtg caagttggag ctggctacaa aggcccagag tctccagaaa     2460

tccttgaaac tcatcatatt tcaagttgaa caagctctgg atgaggaaag cagacagaca     2520

atatctgtta agaactttag ttcaactttc ttcctggaag atgacccaga agatattaac     2580

cagacaagcc cacgacgccg ttctcgtcgt ggcactttgt cttctatatc ttctctcaaa     2640

agtgaggacc tggacaacct taacttggat cacttacatt ttacacctga atctatacgc     2700

ttcaaagaaa aatgtgtcat gaacaactac ttcggaattg gactggatgc taaaatttct     2760

ctggacttca acaccagaag agatgaacac ccagggcaat acaatagccg ccttaagaac     2820

aagatgtggt atggccttct gggaaccaaa gaacttttgc agcgctctta caggaaactg     2880

gaagaacgag tgcatttgga gtgtgatgga gaaaccatct ccttgccaaa cctgcaaggc     2940

attgtagtgc tcaacattac cagctatgct ggaggtatca acttctgggg aagcaacaca     3000

gcaaccacgg aatatgaggc tcctgcaatc gatgatggga aactggaggt ggtggcaatc     3060

tttggttctg tgcagatggc aatgtcccgt atcatcaacc tgcatcatca tcgcattgcc     3120

cagtgccatg aggtgatgat aaccattgat ggtgaagaag gtatcccagt gcaggtggat     3180

ggggaggcct ggattcagag accaggcctt atcaaaatta gatacaagaa cgctgcccag     3240

atgctgacaa gagatcggga ctttgagaac tcaatgaaaa tgtgggaata caagcatact     3300

gaaattcaag ctgcccctca accccagctg gacttccagg actctcaaga gagcctctct     3360

gacgaggagt atgcccagat gcagcactta gctcggcttg cagaaaacct catcagcaaa     3420

cttaatgacc tgagcaagat ccaccagcat gtgtctgtcc tcatgggttc tgtgaatgcc     3480

agcgctaaca tcctgaatga tatattttac ggccaagaca gtggcaatga gatgggtgca     3540

gcttcctgta ttcccattga aactctaagc agaaatgatg ccgtagatgt tacatttagt     3600

cttaaaggtc tctacgatga caccacagct ttcctggatg aaaagctgct gagaagtgct     3660

gaggatgaga ctgcactaca aagcgccctg gatgccatga ataaggagtt caaaaagcta     3720

tctgagattg actggatgaa tccaatcttt gttccagagg aaaaatcttc ggacactgac     3780

agtagaagcc tcaggctgaa aattaagttc cccaaattgg gaaagaaaaa ggtagaagag     3840

gaacgcaagc ctaaatcagg ccagagtgtc cagagtttta ttggcaattt atggcaccgc     3900

agacatcgtg aagatgaagc agagggtgat gatcctctaa caccatcgag atctcaactg     3960

tagcccttga aagctggaag aactcacaac attgagaatt ctactaaaaa aactctcaaa     4020

acctcaatac aggctagact aaatcatttc agaacaaaca tgagcaccac caagaaagac     4080

cctccaattc ttttcactaa tgcattttcc tggacttaat ctggtctcct tagaggttta     4140

catttcctca ttggccaaag gttcttgttc cgagttgtct tgttcagttc tccttctctt     4200

tgtgcatctt gagcaactac agtatttatt gggataagct ctttatgaat ggcctgggat     4260

ctataaagga ttcaagggag ttcacctctt cagggagttt tggaatggtt ttctctgacc     4320

agcagagaaa ctatcaatgc taaggaatga atgaaagaca cacagactcc cagggagatg     4380

aagagaaggg ggcaggcagg acagccagac ttggttgtgt gtctctccga atccctgcca     4440

actgcaactt gcaccttcag gagatctctt ctagttggct cattaaaatg agaactagat     4500

cctgggggct tgtccacttt cctgttaaga tgaccatgtg aaatctcttt ttgtagatat     4560

ggtaacctct ctctctctct gcaaaccctt tgcgtttttc tatgtgtgct tgtatgtctg     4620

catatgtcca ggtggtgctc tggtgggctc attggttgga actcacccct catggcaacc     4680

atacaggctc ccctcctgct gccttgatcc tagcctgcat gcctccacgg agtgtttgcc     4740

tgcattcttg ctggattttt taactaaatg ttttgccgct gtgctgcagt atagattatg     4800

tatagagaca taaagatgta tatatatata catacgcata tatattttta agagctgaaa     4860

atacaactcg acctctaagt gaccctataa tttattgtgc taatccagga atcccttccc     4920

actccccctt actctacata acaataacac atacacctct accaactgcc ctatttcttg     4980

gtggagcttc taaatctttt ggtgcatttt cagcgtctta gaggtggctg ggatctatgg     5040

cccagctgat tctgacgccc ccttaaaatt ctgagccagg ccatggaaag gggaacaaaa     5100

acaccaatgc cctaaagaag gggtttaagc tggcatgctg cctttttttg ctctatctgt     5160

cctagactct tcatcagcaa ctgtgccctt ccccaataaa aagactatat ggagcaacca     5220

ggccttgagc tctgtgactt agatgcctga actagggact gcctgacaat taagtcacag     5280

cctaggccct tccccacaag ctccatcttg gcctgatctt ctggacaggc tgttgggtca     5340

gtcctcaagt caccttcaaa tctcccatct tgcccttttc ccttgagtac agaggggcat     5400

tgaagtgatc agaaaaaaca tgggcctgga gaaatgaagg ctagaagcct gtgctttcct     5460

gtggttcttc ttgcaaattt ctcatgaaaa caaactattc ctaaatcgct ccaaatacta     5520

attcacattt ttcaaaaatg ccttctccca gtcagggcaa atctaatcaa accccaatgc     5580

ccagagaggt tctctctggt cagccttgca tcttcacccc acccttgact cataccttta     5640

gttaactgtc ccttcccact tatcaagaga aaactggcct ctccctactt ctcagacaaa     5700

cttagcgtgc tcaattacct gattcagtcc aatggctggt tcattgaggt gcacaattca     5760

gattccaagc actggttctc aactctggaa ctccaccagc ctaacccact taaaccagcc     5820

acctgtgctc cacctccgca ggggtgagga gaaaaatatt aacaagggga tagtccccaa     5880

atgtctgatt gctgtgccaa actaagtcct agctctacaa ctagagaaga aagtcaatgg     5940

aaaaagatga cagaaaacat ttaaaactta tttaagcatc agaatgtgtt agcttgttgt     6000

acatatttga gtagtgagtg tgctgttgtt gtgtctttga ctttctctgt tattagtctt     6060

tcttcccagg aggaggtatt agatgaaatc agcaagctca ctattgcagc ctgacttggc     6120

tcctctatgg ctgcatgcat tgacacctgc acacacactc acagagtggg aaccaagttg     6180

cattttcttc agaagagctt tttccgaagg ggaaaatgtc caaatgagca aatttaggac     6240

tacagaagga agtcctggga gaagatagct ttatcttggc agtgactaag cagggctgtg     6300

tcttataatt atttttatca ctgatgatag taaactgtaa taagactcca tctcttgtgc     6360

ttactttgct gcaataatta ggtctttgtg cacagtgatg ctgctgttgc tctgttgtgc     6420

catgtggatt ccctttcacc taccctgtcc tcccactctg agtcagaatg atattgactg     6480

aaaccactag tatttggggc tagagtcagc tcatggagca cagttgatag atgacaaggc     6540

ccaggagcag gtgtggcttg ctcaatccct cagttacctc ctaaattgct aagttaccag     6600

tagtttccca aaaaggaaga tagcttgcca agcacctgtt cttgcatatg ctcacttgga     6660

aacaaagcaa gaagtgatgc ctcaagggag ttgtcttagc tctgggagtg tgagctcctt     6720

taaggacttt gttaaccact tgcagtaatt aatacaattg cttgggtggt gggaccaaac     6780

accaaatatc catctcaatt atgttcagac atcattaaga cccaaagctc tagggtttgg     6840

ttgtatcttt ggtagcactt tctgacgaat tggttgggta ggcaattcct ggccagaaga     6900

atagtggaga agaaaaagcc gatacatttg aactgccacc aactgcttct ggtgtcaata     6960

ctataggagg taaacagtta tgggtcccct tctccagaaa ggccctgtgc tgtgtccata     7020

agagcaggtt aagaataaga aagagatttt ttaccttaat aaaactgggc cagaagaaac     7080

agtcagggtc aacgtcatct tccctcagga cacaaatgga agaatttttc tttcacgaga     7140

ggtggaaaat aataccaaag caaccaaacc cattagcacc attccatcct atatgagacc     7200

ttgcttggct atatgatttg tggaattgca tttgtctatt tgtcagtgaa tctgtaaccc     7260

attgttgttt tctgctctgt gttttttatt tcctcagagg cccctgcaaa taagcagcag     7320

ggccaggggc tggttggggg aggaagctgg ggtatttaca tggtaacagg aaaaagcaga     7380

aaaaaaagat ccacaaagtg tgcctattcc tctccccccg ccaaatggaa caccagtcct     7440

caatgttaat aaagtattgc ttctttaaat attttaataa atggataaac ataa           7494


<210>  30
<211>  1271
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Asp Arg Gly Ala Ala Ala Ala Gln Gly Thr Ala Pro Pro Gln Asp 
1               5                   10                  15      


Gly Glu Gln Pro Ala Glu Ser Pro Glu Pro Pro Pro Pro Trp Pro Pro 
            20                  25                  30          


Pro Pro Pro Pro Pro Ala Pro Pro Pro Ala Pro Pro Leu Leu Ser Glu 
        35                  40                  45              


Ala Ser Pro Glu Pro Ile Pro Glu Pro Cys Pro Glu Leu Ala Pro Gly 
    50                  55                  60                  


Pro Cys Pro Glu Ala Thr Ser Glu Ser Ala Thr Glu Leu Tyr Thr Glu 
65                  70                  75                  80  


Pro Thr Pro Glu Pro Ala Thr Glu Pro Ala Ser Glu Pro Ala Pro Glu 
                85                  90                  95      


Pro Ala Thr Glu Pro Ala Pro Glu Pro Ala Thr Glu Pro Ala Pro Glu 
            100                 105                 110         


Pro Ala Pro Glu Pro Ala Thr Glu Ser Ala Pro Glu Pro Thr Pro Glu 
        115                 120                 125             


Pro Ala Leu Glu Ser Val Pro Glu Pro Ala Pro Glu Leu Thr Pro Glu 
    130                 135                 140                 


Val Ala Pro Glu Leu Ala Pro Glu Pro Thr Pro Glu Pro Val Thr Glu 
145                 150                 155                 160 


Leu Ala Pro Glu Phe Cys Pro Glu Ala Ala Pro Glu Phe Arg Pro Ser 
                165                 170                 175     


Pro Ala Pro Cys Leu Leu Gln Cys Pro Val Asp Thr Arg Glu Arg Gly 
            180                 185                 190         


Leu Lys Thr Ser Pro Ser Pro Ser Pro Ser Pro Ser Pro Arg Thr Pro 
        195                 200                 205             


Met Ser Trp Ser Arg Ile Lys Lys Ile Leu Lys Glu Gly Pro Met Leu 
    210                 215                 220                 


Lys Asn Cys Asn Ser Phe Lys Arg Trp Lys Leu Arg Tyr Phe Leu Val 
225                 230                 235                 240 


Gln Gly Gln Lys Leu Tyr Phe Ala His His Pro Ala Phe Ala His Phe 
                245                 250                 255     


Glu Thr Ile Asp Leu Ser Gln Ala Thr Val Ala Glu Ser Ser Cys Arg 
            260                 265                 270         


Asn Leu Cys His Ser Phe Cys Val Ile Thr Pro Gln Arg Lys Ile Thr 
        275                 280                 285             


Leu Ala Ala Pro Asn Arg Lys Asp Met Glu Glu Trp Ile Asn Ile Ile 
    290                 295                 300                 


Lys Thr Ile Gln Gln Gly Glu Ile Tyr Lys Ile Pro Ala Ala Glu Asn 
305                 310                 315                 320 


Asn Pro Phe Leu Val Gly Met His Cys Trp Tyr Ser Ser Tyr Ser His 
                325                 330                 335     


Arg Thr Gln His Cys Asn Val Cys Arg Glu Ser Ile Pro Ala Leu Ser 
            340                 345                 350         


Arg Asp Ala Ile Ile Cys Glu Val Cys Lys Val Lys Ser His Arg Leu 
        355                 360                 365             


Cys Ala Leu Arg Ala Ser Lys Asp Cys Lys Trp Asn Thr Leu Ser Ile 
    370                 375                 380                 


Thr Asp Asp Leu Leu Leu Pro Ala Asp Glu Val Asn Met Pro His Gln 
385                 390                 395                 400 


Trp Val Glu Gly Asn Met Pro Val Ser Ser Gln Cys Ala Val Cys His 
                405                 410                 415     


Glu Ser Cys Gly Ser Tyr Gln Arg Leu Gln Asp Phe Arg Cys Leu Trp 
            420                 425                 430         


Cys Asn Ser Thr Val His Asp Asp Cys Arg Arg Arg Phe Ser Lys Glu 
        435                 440                 445             


Cys Cys Phe Arg Ser His Arg Ser Ser Val Ile Pro Pro Thr Ala Leu 
    450                 455                 460                 


Ser Asp Pro Lys Gly Asp Gly Gln Leu Val Val Ser Ser Asp Phe Trp 
465                 470                 475                 480 


Asn Leu Asp Trp Ser Ser Ala Cys Ser Cys Pro Leu Leu Ile Phe Ile 
                485                 490                 495     


Asn Ser Lys Ser Gly Asp His Gln Gly Ile Val Phe Leu Arg Lys Phe 
            500                 505                 510         


Lys Gln Tyr Leu Asn Pro Ser Gln Val Phe Asp Leu Leu Lys Gly Gly 
        515                 520                 525             


Pro Glu Ala Gly Leu Ser Met Phe Lys Asn Phe Ala Arg Phe Arg Ile 
    530                 535                 540                 


Leu Val Cys Gly Gly Asp Gly Ser Val Ser Trp Val Leu Ser Leu Ile 
545                 550                 555                 560 


Asp Ala Phe Gly Leu His Glu Lys Cys Gln Leu Ala Val Ile Pro Leu 
                565                 570                 575     


Gly Thr Gly Asn Asp Leu Ala Arg Val Leu Gly Trp Gly Ala Phe Trp 
            580                 585                 590         


Asn Lys Ser Lys Ser Pro Leu Asp Ile Leu Asn Arg Val Glu Gln Ala 
        595                 600                 605             


Ser Val Arg Ile Leu Asp Arg Trp Ser Val Met Ile Arg Glu Thr Pro 
    610                 615                 620                 


Arg Gln Thr Pro Leu Leu Lys Gly Gln Val Glu Met Asp Val Pro Arg 
625                 630                 635                 640 


Phe Glu Ala Ala Ala Ile Gln His Leu Glu Ser Ala Ala Thr Glu Leu 
                645                 650                 655     


Asn Lys Ile Leu Lys Ala Lys Tyr Pro Thr Glu Met Ile Ile Ala Thr 
            660                 665                 670         


Arg Phe Leu Cys Ser Ala Val Glu Asp Phe Val Val Asp Ile Val Lys 
        675                 680                 685             


Ala Trp Gly Gln Ile Lys Gln Asn Asn Thr Ala Ile Val Ser Val Ile 
    690                 695                 700                 


Leu Lys Ser Asp Leu Met Tyr Asp Arg Leu Ser Val Leu Ile Asp Val 
705                 710                 715                 720 


Leu Ala Glu Glu Ala Ala Ala Thr Ser Ala Glu Lys Ser Ala Thr Glu 
                725                 730                 735     


Tyr Ala Asp Ser Ser Lys Ala Asp Arg Lys Pro Phe Ile Pro Gln Ile 
            740                 745                 750         


Asp His Ile Ala Lys Cys Lys Leu Glu Leu Ala Thr Lys Ala Gln Ser 
        755                 760                 765             


Leu Gln Lys Ser Leu Lys Leu Ile Ile Phe Gln Val Glu Gln Ala Leu 
    770                 775                 780                 


Asp Glu Glu Ser Arg Gln Thr Ile Ser Val Lys Asn Phe Ser Ser Thr 
785                 790                 795                 800 


Phe Phe Leu Glu Asp Asp Pro Glu Asp Ile Asn Gln Thr Ser Pro Arg 
                805                 810                 815     


Arg Arg Ser Arg Arg Gly Thr Leu Ser Ser Ile Ser Ser Leu Lys Ser 
            820                 825                 830         


Glu Asp Leu Asp Asn Leu Asn Leu Asp His Leu His Phe Thr Pro Glu 
        835                 840                 845             


Ser Ile Arg Phe Lys Glu Lys Cys Val Met Asn Asn Tyr Phe Gly Ile 
    850                 855                 860                 


Gly Leu Asp Ala Lys Ile Ser Leu Asp Phe Asn Thr Arg Arg Asp Glu 
865                 870                 875                 880 


His Pro Gly Gln Tyr Asn Ser Arg Leu Lys Asn Lys Met Trp Tyr Gly 
                885                 890                 895     


Leu Leu Gly Thr Lys Glu Leu Leu Gln Arg Ser Tyr Arg Lys Leu Glu 
            900                 905                 910         


Glu Arg Val His Leu Glu Cys Asp Gly Glu Thr Ile Ser Leu Pro Asn 
        915                 920                 925             


Leu Gln Gly Ile Val Val Leu Asn Ile Thr Ser Tyr Ala Gly Gly Ile 
    930                 935                 940                 


Asn Phe Trp Gly Ser Asn Thr Ala Thr Thr Glu Tyr Glu Ala Pro Ala 
945                 950                 955                 960 


Ile Asp Asp Gly Lys Leu Glu Val Val Ala Ile Phe Gly Ser Val Gln 
                965                 970                 975     


Met Ala Met Ser Arg Ile Ile Asn Leu His His His Arg Ile Ala Gln 
            980                 985                 990         


Cys His Glu Val Met Ile Thr Ile  Asp Gly Glu Glu Gly  Ile Pro Val 
        995                 1000                 1005             


Gln Val  Asp Gly Glu Ala Trp  Ile Gln Arg Pro Gly  Leu Ile Lys 
    1010                 1015                 1020             


Ile Arg  Tyr Lys Asn Ala Ala  Gln Met Leu Thr Arg  Asp Arg Asp 
    1025                 1030                 1035             


Phe Glu  Asn Ser Met Lys Met  Trp Glu Tyr Lys His  Thr Glu Ile 
    1040                 1045                 1050             


Gln Ala  Ala Pro Gln Pro Gln  Leu Asp Phe Gln Asp  Ser Gln Glu 
    1055                 1060                 1065             


Ser Leu  Ser Asp Glu Glu Tyr  Ala Gln Met Gln His  Leu Ala Arg 
    1070                 1075                 1080             


Leu Ala  Glu Asn Leu Ile Ser  Lys Leu Asn Asp Leu  Ser Lys Ile 
    1085                 1090                 1095             


His Gln  His Val Ser Val Leu  Met Gly Ser Val Asn  Ala Ser Ala 
    1100                 1105                 1110             


Asn Ile  Leu Asn Asp Ile Phe  Tyr Gly Gln Asp Ser  Gly Asn Glu 
    1115                 1120                 1125             


Met Gly  Ala Ala Ser Cys Ile  Pro Ile Glu Thr Leu  Ser Arg Asn 
    1130                 1135                 1140             


Asp Ala  Val Asp Val Thr Phe  Ser Leu Lys Gly Leu  Tyr Asp Asp 
    1145                 1150                 1155             


Thr Thr  Ala Phe Leu Asp Glu  Lys Leu Leu Arg Ser  Ala Glu Asp 
    1160                 1165                 1170             


Glu Thr  Ala Leu Gln Ser Ala  Leu Asp Ala Met Asn  Lys Glu Phe 
    1175                 1180                 1185             


Lys Lys  Leu Ser Glu Ile Asp  Trp Met Asn Pro Ile  Phe Val Pro 
    1190                 1195                 1200             


Glu Glu  Lys Ser Ser Asp Thr  Asp Ser Arg Ser Leu  Arg Leu Lys 
    1205                 1210                 1215             


Ile Lys  Phe Pro Lys Leu Gly  Lys Lys Lys Val Glu  Glu Glu Arg 
    1220                 1225                 1230             


Lys Pro  Lys Ser Gly Gln Ser  Val Gln Ser Phe Ile  Gly Asn Leu 
    1235                 1240                 1245             


Trp His  Arg Arg His Arg Glu  Asp Glu Ala Glu Gly  Asp Asp Pro 
    1250                 1255                 1260             


Leu Thr  Pro Ser Arg Ser Gln  Leu 
    1265                 1270     


<210>  31
<211>  4649
<212>  DNA
<213>  Homo sapiens

<400>  31
agtcggaagc agtgtaccgg gccgtggagc ggcggctcct gtacccccgg cgcggaccta       60

aaggggctcg ggccgctcgg gccgggaatg gcggcggcgg ccgagcccgg ggcccgcgcc      120

tggctgggcg gcggctcccc gcgccccggc agcccggcct gcagccccgt gctgggctca      180

ggaggccgcg cgcgcccggg gccggggccg gggccgggac ccgagcgggc gggcgtcaga      240

gccccgggcc ccgctgccgc gccgggacac agcttccgga aggtgacgct caccaagccc      300

accttctgcc acctctgctc cgacttcatc tgggggctgg ccggcttcct gtgcgacgtc      360

tgcaatttca tgtctcatga gaagtgcctg aagcacgtga ggatcccgtg cacgagtgtg      420

gcacccagcc tggtccgggt tcctgtagcc cactgcttcg gcccccgggg gctccacaag      480

cgcaagttct gtgctgtctg ccgcaaggtc ctggaggcac cggcgctcca ctgcgaagtg      540

tgtgagctgc acctccaccc agactgtgtg cccttcgcct gcagtgactg ccgccagtgc      600

caccaggatg ggcaccagga tcacgacacc catcaccacc actggcggga ggggaacctg      660

ccctcgggag cgcgctgcga ggtctgcagg aagacgtgcg gctcctctga cgtgctggcc      720

ggcgtgcgct gcgagtggtg cggggtccag gcgcactccc tctgctccgc ggcgctggct      780

cccgagtgtg gcttcgggcg tctgcgctcc ctggtcctgc ctcccgcgtg cgtgcgcctt      840

ctgcccggcg gcttcagcaa gacgcagagc ttccgcatcg tggaggccgc ggagccgggc      900

gaggggggcg acggcgccga cgggagcgct gccgtgggtc caggcagaga gacacaggca      960

actccggagt ccgggaagca aacgctgaag atctttgatg gcgacgacgc ggtgagaaga     1020

agccagttcc gcctcgtcac ggtgtcccgc ctggccggtg ccgaggaggt gctggaggcc     1080

gcactgcggg cccaccacat ccccgaggac cctggccacc tggagctgtg ccggctgccc     1140

ccttcctctc aggcctgtga cgcctgggct gggggcaagg ctgggagtgc tgtgatctcg     1200

gaggagggca gaagccccgg gtccggcgag gccacgccag aggcctgggt catccgggct     1260

ctgccgcggg cccaggaggt cctgaagatc taccctggct ggctcaaggt gggcgtggcc     1320

tacgtgtccg tgcgagtgac cccgaagagc acggcccgct ctgtggtgct ggaggtcctg     1380

ccgctgctcg gccgccaggc cgagagtccc gagagcttcc agctggtgga ggtggcgatg     1440

ggctgcaggc acgtccagcg gacgatgctg atggacgaac agcccctgct ggaccggcta     1500

caggacatcc ggcagatgtc tgtgcggcag gtgagccaga cgcggttcta cgtggcagag     1560

agcagggatg tagccccgca cgtctccctg tttgttggcg gcctgcctcc cggcctgtct     1620

cccgaggagt acagcagcct gctgcatgag gccggggcta ccaaagccac cgtggtgtcc     1680

gtgagtcaca tctactcctc ccaaggcgcg gtagtgttgg acgttgcctg ctttgcggag     1740

gccgagcggc tgtacatgct gctgaaggac atggctgtgc ggggccggct gctcactgcc     1800

ctggtgctcc ccgacctgct gcacgcgaag ctgcccccag acagctgtcc cctccttgtg     1860

ttcgtgaacc ccaagagtgg aggcctcaag ggccgagacc tgctctgcag cttccggaag     1920

ctactgaacc ctcatcaggt cttcgacctg accaacggag gtcctcttcc cgggctccac     1980

ctgttctccc aggtgccctg cttccgggtg ctggtgtgtg gtggcgatgg cactgtgggc     2040

tgggtgcttg gcgccctgga ggagacacgg taccgactgg cctgcccgga gccttctgtg     2100

gccatcctgc ccctgggcac agggaatgac cttggtcgag tcctccgctg gggggcgggc     2160

tacagcggcg aggacccgtt ctccgtactg ctgtctgtgg acgaggccga cgccgtgctc     2220

atggaccgct ggaccatcct gctggatgcc cacgaggctg gcagtgcaga gaacgacacg     2280

gcagacgcag agccccccaa gatcgtgcag atgagtaact actgtggcat tggcatcgac     2340

gcggagctga gcctggactt ccaccaggca cgggaagagg agcctggcaa gttcacaagc     2400

aggctgcaca acaagggtgt gtacgtgcgg gtggggctgc agaagatcag tcactctcgg     2460

agcctgcaca agcagatccg gctgcaggtg gagcggcagg aggtggagct gcccagtatt     2520

gaaggcctca tcttcatcaa catccccagc tggggctcgg gggccgacct gtggggctcc     2580

gacagcgaca ccaggtttga gaagccacgc atggacgacg ggctgctgga ggttgtgggc     2640

gtgacgggcg tcgtgcacat gggccaggtc cagggtgggc tgcgctccgg aatccggatt     2700

gcccagggtt cctacttccg agtcacgctc ctcaaggcca ccccggtgca ggtggacggg     2760

gagccctggg tccaggcccc ggggcacatg atcatctcag ctgctggccc taaggtgcac     2820

atgctgagga aggccaagca gaagccgagg agggccggga ccaccaggga tgcccgggcg     2880

gatgctgcgc ctgcccctga gagcgatcct aggtaggggt ggctggggca gcccaagggc     2940

tcgagccatc tctgctcccg ccagccttgt tttcaggtgg tctggaggca gctccacgtc     3000

cacacagtgg ccggccctgt ggtcggacct ggctacagcc ctgaccacag catcttccca     3060

gtgacggagc gggacccgcc ctcatcccat tggtgacaca tgttggtgtc acagccctca     3120

tcccactgga gactggtgtg cgggtggcag tgttaccccg tgtcccgggt gggcgcaggg     3180

ctctggatgg tgagccctct gccctgtggg ggcctggtcc tctcctcagg ggtgggcacc     3240

catccctctc cccactgagc cccttgagct ggacagtgct ggatgcaggc cgtccaggtg     3300

ggtctgatct cactttgtgc ccctcgggcc gtccccctgg ccagtcctta agagcagcag     3360

gctccctggt gtgtccctgc cccagcagac acaggctgcc agtccctcca gcctcacctc     3420

cccgccctgg gcagcaggtg tgggcagcgt gtgaggctgc cgggtggtgg tgactggtga     3480

cttccttgtg ttcagggaag ggagaaggtg ccttcccttg ttttctggcc ttgttatata     3540

cagatggcag cttggatctc aggtacagct ccaggggcag gcagtgccca gctggacctg     3600

gtggcccttt cctagtgcct ctgcttgggg aggagaacct ctgtccacgt ggaggctagg     3660

aggtctcagg tgctgccctg gcagcaccag agtgtgggcc gggcccgagt gtctgcccct     3720

cggccctcag ggtggggcac ttagcaccca gaagggacca aaagcagggc atggcggtgc     3780

agaggagttt gggaggtgta aacagcccat gcacgtggag gaggagctgg ctttcagccc     3840

cagaccccac gctagcactt tccacgctgc ttgcccgctg ttgatgtgca gttcccagtg     3900

cctgtgtgag ccgacatctg ctcagtccta tccctcgtca gcgtgtggag acccagctcc     3960

tgcagccctc ctgctcccac gcccccagac agcttggtgg agggtcctgc atctgggcca     4020

ggctggggtg cacccagcca aagacaaagc tgcctccacg tgcccaagga ttcagatggt     4080

gcactggccc cgggaggagt ctgaccaaaa atggagcccg ctctgtgggg aagccccgac     4140

tcccccacga gaaacggtcc cacggtgcgg atctccccct tcccttgtgg ggcacagctg     4200

gcctgggcct ccaatcctgc ggagctttcc tgggtgtggc tttgacctca gaagtggctc     4260

tggtttggcc tcaggagtgt ggcctggccc agcctgctgc agcctcctgg ggggcccttg     4320

atgccactaa tcccccgacc ccccgcatct gccaaactgc acagacacac gcattgtaag     4380

gccgcttgtg gcctccagcg tgcactcttg tttacgtcat tgtcatcttc aagaccagtc     4440

ctttgtgatt agttttgctt cgcgagccct ggtgtggact gtggtctgta tgaatcgtgt     4500

gtaactgtgg tgaggggctt gtcctgtatg tgagtctgta cccaggtggg gtctgtgccc     4560

tgcacaccgg gcccctctgt atttatcgct gcctgaatgc aacagtaatt tatatccagg     4620

acaaatacag tctgggcgtc actatccta                                       4649


<210>  32
<211>  942
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Ala Ala Ala Glu Pro Gly Ala Arg Ala Trp Leu Gly Gly Gly 
1               5                   10                  15      


Ser Pro Arg Pro Gly Ser Pro Ala Cys Ser Pro Val Leu Gly Ser Gly 
            20                  25                  30          


Gly Arg Ala Arg Pro Gly Pro Gly Pro Gly Pro Gly Pro Glu Arg Ala 
        35                  40                  45              


Gly Val Arg Ala Pro Gly Pro Ala Ala Ala Pro Gly His Ser Phe Arg 
    50                  55                  60                  


Lys Val Thr Leu Thr Lys Pro Thr Phe Cys His Leu Cys Ser Asp Phe 
65                  70                  75                  80  


Ile Trp Gly Leu Ala Gly Phe Leu Cys Asp Val Cys Asn Phe Met Ser 
                85                  90                  95      


His Glu Lys Cys Leu Lys His Val Arg Ile Pro Cys Thr Ser Val Ala 
            100                 105                 110         


Pro Ser Leu Val Arg Val Pro Val Ala His Cys Phe Gly Pro Arg Gly 
        115                 120                 125             


Leu His Lys Arg Lys Phe Cys Ala Val Cys Arg Lys Val Leu Glu Ala 
    130                 135                 140                 


Pro Ala Leu His Cys Glu Val Cys Glu Leu His Leu His Pro Asp Cys 
145                 150                 155                 160 


Val Pro Phe Ala Cys Ser Asp Cys Arg Gln Cys His Gln Asp Gly His 
                165                 170                 175     


Gln Asp His Asp Thr His His His His Trp Arg Glu Gly Asn Leu Pro 
            180                 185                 190         


Ser Gly Ala Arg Cys Glu Val Cys Arg Lys Thr Cys Gly Ser Ser Asp 
        195                 200                 205             


Val Leu Ala Gly Val Arg Cys Glu Trp Cys Gly Val Gln Ala His Ser 
    210                 215                 220                 


Leu Cys Ser Ala Ala Leu Ala Pro Glu Cys Gly Phe Gly Arg Leu Arg 
225                 230                 235                 240 


Ser Leu Val Leu Pro Pro Ala Cys Val Arg Leu Leu Pro Gly Gly Phe 
                245                 250                 255     


Ser Lys Thr Gln Ser Phe Arg Ile Val Glu Ala Ala Glu Pro Gly Glu 
            260                 265                 270         


Gly Gly Asp Gly Ala Asp Gly Ser Ala Ala Val Gly Pro Gly Arg Glu 
        275                 280                 285             


Thr Gln Ala Thr Pro Glu Ser Gly Lys Gln Thr Leu Lys Ile Phe Asp 
    290                 295                 300                 


Gly Asp Asp Ala Val Arg Arg Ser Gln Phe Arg Leu Val Thr Val Ser 
305                 310                 315                 320 


Arg Leu Ala Gly Ala Glu Glu Val Leu Glu Ala Ala Leu Arg Ala His 
                325                 330                 335     


His Ile Pro Glu Asp Pro Gly His Leu Glu Leu Cys Arg Leu Pro Pro 
            340                 345                 350         


Ser Ser Gln Ala Cys Asp Ala Trp Ala Gly Gly Lys Ala Gly Ser Ala 
        355                 360                 365             


Val Ile Ser Glu Glu Gly Arg Ser Pro Gly Ser Gly Glu Ala Thr Pro 
    370                 375                 380                 


Glu Ala Trp Val Ile Arg Ala Leu Pro Arg Ala Gln Glu Val Leu Lys 
385                 390                 395                 400 


Ile Tyr Pro Gly Trp Leu Lys Val Gly Val Ala Tyr Val Ser Val Arg 
                405                 410                 415     


Val Thr Pro Lys Ser Thr Ala Arg Ser Val Val Leu Glu Val Leu Pro 
            420                 425                 430         


Leu Leu Gly Arg Gln Ala Glu Ser Pro Glu Ser Phe Gln Leu Val Glu 
        435                 440                 445             


Val Ala Met Gly Cys Arg His Val Gln Arg Thr Met Leu Met Asp Glu 
    450                 455                 460                 


Gln Pro Leu Leu Asp Arg Leu Gln Asp Ile Arg Gln Met Ser Val Arg 
465                 470                 475                 480 


Gln Val Ser Gln Thr Arg Phe Tyr Val Ala Glu Ser Arg Asp Val Ala 
                485                 490                 495     


Pro His Val Ser Leu Phe Val Gly Gly Leu Pro Pro Gly Leu Ser Pro 
            500                 505                 510         


Glu Glu Tyr Ser Ser Leu Leu His Glu Ala Gly Ala Thr Lys Ala Thr 
        515                 520                 525             


Val Val Ser Val Ser His Ile Tyr Ser Ser Gln Gly Ala Val Val Leu 
    530                 535                 540                 


Asp Val Ala Cys Phe Ala Glu Ala Glu Arg Leu Tyr Met Leu Leu Lys 
545                 550                 555                 560 


Asp Met Ala Val Arg Gly Arg Leu Leu Thr Ala Leu Val Leu Pro Asp 
                565                 570                 575     


Leu Leu His Ala Lys Leu Pro Pro Asp Ser Cys Pro Leu Leu Val Phe 
            580                 585                 590         


Val Asn Pro Lys Ser Gly Gly Leu Lys Gly Arg Asp Leu Leu Cys Ser 
        595                 600                 605             


Phe Arg Lys Leu Leu Asn Pro His Gln Val Phe Asp Leu Thr Asn Gly 
    610                 615                 620                 


Gly Pro Leu Pro Gly Leu His Leu Phe Ser Gln Val Pro Cys Phe Arg 
625                 630                 635                 640 


Val Leu Val Cys Gly Gly Asp Gly Thr Val Gly Trp Val Leu Gly Ala 
                645                 650                 655     


Leu Glu Glu Thr Arg Tyr Arg Leu Ala Cys Pro Glu Pro Ser Val Ala 
            660                 665                 670         


Ile Leu Pro Leu Gly Thr Gly Asn Asp Leu Gly Arg Val Leu Arg Trp 
        675                 680                 685             


Gly Ala Gly Tyr Ser Gly Glu Asp Pro Phe Ser Val Leu Leu Ser Val 
    690                 695                 700                 


Asp Glu Ala Asp Ala Val Leu Met Asp Arg Trp Thr Ile Leu Leu Asp 
705                 710                 715                 720 


Ala His Glu Ala Gly Ser Ala Glu Asn Asp Thr Ala Asp Ala Glu Pro 
                725                 730                 735     


Pro Lys Ile Val Gln Met Ser Asn Tyr Cys Gly Ile Gly Ile Asp Ala 
            740                 745                 750         


Glu Leu Ser Leu Asp Phe His Gln Ala Arg Glu Glu Glu Pro Gly Lys 
        755                 760                 765             


Phe Thr Ser Arg Leu His Asn Lys Gly Val Tyr Val Arg Val Gly Leu 
    770                 775                 780                 


Gln Lys Ile Ser His Ser Arg Ser Leu His Lys Gln Ile Arg Leu Gln 
785                 790                 795                 800 


Val Glu Arg Gln Glu Val Glu Leu Pro Ser Ile Glu Gly Leu Ile Phe 
                805                 810                 815     


Ile Asn Ile Pro Ser Trp Gly Ser Gly Ala Asp Leu Trp Gly Ser Asp 
            820                 825                 830         


Ser Asp Thr Arg Phe Glu Lys Pro Arg Met Asp Asp Gly Leu Leu Glu 
        835                 840                 845             


Val Val Gly Val Thr Gly Val Val His Met Gly Gln Val Gln Gly Gly 
    850                 855                 860                 


Leu Arg Ser Gly Ile Arg Ile Ala Gln Gly Ser Tyr Phe Arg Val Thr 
865                 870                 875                 880 


Leu Leu Lys Ala Thr Pro Val Gln Val Asp Gly Glu Pro Trp Val Gln 
                885                 890                 895     


Ala Pro Gly His Met Ile Ile Ser Ala Ala Gly Pro Lys Val His Met 
            900                 905                 910         


Leu Arg Lys Ala Lys Gln Lys Pro Arg Arg Ala Gly Thr Thr Arg Asp 
        915                 920                 925             


Ala Arg Ala Asp Ala Ala Pro Ala Pro Glu Ser Asp Pro Arg 
    930                 935                 940         


<210>  33
<211>  4072
<212>  DNA
<213>  Homo sapiens

<400>  33
caaactagga cttgctcagc agaggccgcc agcccggagc tggatccaga gcccggcctt       60

ggggacccca gctcccacct gcgccctgcc ttccagatca gccaaccgcc tgccatggag      120

actttcttta ggagacattt ccgggggaag gtgccaggcc ctggagaggg gcagcagcgg      180

cccagcagcg tggggctgcc cacaggcaag gcccggcgtc gctcccccgc tgggcaggcc      240

tcctcctcac tggcacagcg gcgccgctcc agcgcccagc tccagggctg cctcctgagt      300

tgcggggtga gggcccaggg ttccagccgc cggcgctcca gcactgtgcc cccttcctgc      360

aacccccgct tcatcgtgga taaggtgctc actccacagc ctaccaccgt gggggcccag      420

cttctgggtg cacccctgct gttgaccggg cttgtgggca tgaatgagga ggagggtgtc      480

caggaggatg tggtagccga ggcatcgagc gccatccagc caggcaccaa gacaccaggg      540

ccacccccac ctcggggcgc ccagccgctg ttgcccctac cccgctacct gcgccgagcc      600

tcctcccacc tgctccccgc ggatgccgta tatgaccacg ctctctgggg cctgcacggc      660

tactatcggc gcctcagcca gcggcggccc tcaggccagc accctggccc tgggggccga      720

agagcctcag gcaccaccgc cggcaccatg ctgcccaccc gtgtgcgccc actgtcccgc      780

aggcgccagg tagccctacg gcgcaaggcg gccggacccc aggcctggag cgccctgctc      840

gcgaaagcca tcaccaagtc gggcctccag cacctggccc cccctccgcc cacccctggg      900

gccccgtgca gcgagtcaga gcggcagatc cggagtacag tggactggag cgagtcagcg      960

acatatgggg agcacatctg gttcgagacc aacgtgtccg gggacttctg ctacgttggg     1020

gagcagtact gtgtagccag gatgctgaag tcagtgtctc gaagaaagtg cgcagcctgc     1080

aagattgtgg tgcacacgcc ctgcatcgag cagctggaga agataaattt ccgctgtaag     1140

ccgtccttcc gtgaatcagg ctccaggaat gtccgcgagc caacctttgt acggcaccac     1200

tgggtacaca gacgacgcca ggacggcaag tgtcggcact gtgggaaggg attccagcag     1260

aagttcacct tccacagcaa ggagattgtg gccatcagct gctcgtggtg caagcaggca     1320

taccacagca aggtgtcctg cttcatgctg cagcagatcg aggagccgtg ctcgctgggg     1380

gtccacgcag ccgtggtcat cccgcccacc tggatcctcc gcgcccggag gccccagaat     1440

actctgaaag caagcaagaa gaagaagagg gcatccttca agaggaagtc cagcaagaaa     1500

gggcctgagg agggccgctg gagacccttc atcatcaggc ccaccccctc cccgctcatg     1560

aagcccctgc tggtgtttgt gaaccccaag agtgggggca accagggtgc aaagatcatc     1620

cagtctttcc tctggtatct caatccccga caagtcttcg acctgagcca gggagggccc     1680

aaggaggcgc tggagatgta ccgcaaagtg cacaacctgc ggatcctggc gtgcgggggc     1740

gacggcacgg tgggctggat cctctccacc ctggaccagc tacgcctgaa gccgccaccc     1800

cctgttgcca tcctgcccct gggtactggc aacgacttgg cccgaaccct caactggggt     1860

gggggctaca cagatgagcc tgtgtccaag atcctctccc acgtggagga ggggaacgtg     1920

gtacagctgg accgctggga cctccacgct gagcccaacc ccgaggcagg gcctgaggac     1980

cgagatgaag gcgccaccga ccggttgccc ctggatgtct tcaacaacta cttcagcctg     2040

ggctttgacg cccacgtcac cctggagttc cacgagtctc gagaggccaa cccagagaaa     2100

ttcaacagcc gctttcggaa taagatgttc tacgccggga cagctttctc tgacttcctg     2160

atgggcagct ccaaggacct ggccaagcac atccgagtgg tgtgtgatgg aatggacttg     2220

actcccaaga tccaggacct gaaaccccag tgtgttgttt tcctgaacat ccccaggtac     2280

tgtgcgggca ccatgccctg gggccaccct ggggagcacc acgactttga gccccagcgg     2340

catgacgacg gctacctcga ggtcattggc ttcaccatga cgtcgttggc cgcgctgcag     2400

gtgggcggac acggcgagcg gctgacgcag tgtcgcgagg tggtgctcac cacatccaag     2460

gccatcccgg tgcaggtgga tggcgagccc tgcaagcttg cagcctcacg catccgcatc     2520

gccctgcgca accaggccac catggtgcag aaggccaagc ggcggagcgc cgcccccctg     2580

cacagcgacc agcagccggt gccagagcag ttgcgcatcc aggtgagtcg cgtcagcatg     2640

cacgactatg aggccctgca ctacgacaag gagcagctca aggaggcctc tgtgccgctg     2700

ggcactgtgg tggtcccagg agacagtgac ctagagctct gccgtgccca cattgagaga     2760

ctccagcagg agcccgatgg tgctggagcc aagtccccga catgccagaa actgtccccc     2820

aagtggtgct tcctggacgc caccactgcc agccgcttct acaggatcga ccgagcccag     2880

gagcacctca actatgtgac tgagatcgca caggatgaga tttatatcct ggaccctgag     2940

ctgctggggg catcggcccg gcctgacctc ccaaccccca cttcccctct ccccacctca     3000

ccctgctcac ccacgccccg gtcactgcaa ggggatgctg caccccctca aggtgaagag     3060

ctgattgagg ctgccaagag gaacgacttc tgtaagctcc aggagctgca ccgagctggg     3120

ggcgacctca tgcaccgaga cgagcagagt cgcacgctcc tgcaccacgc agtcagcact     3180

ggcagcaagg atgtggtccg ctacctgctg gaccacgccc ccccagagat ccttgatgcg     3240

gtggaggaaa acggggagac ctgtttgcac caagcagcgg ccctgggcca gcgcaccatc     3300

tgccactaca tcgtggaggc cggggcctcg ctcatgaaga cagaccagca gggcgacact     3360

ccccggcagc gggctgagaa ggctcaggac accgagctgg ccgcctacct ggagaaccgg     3420

cagcactacc agatgatcca gcgggaggac caggagacgg ctgtgtagcg ggccgcccac     3480

gggcagcagg agggacaatg cggccagggg acgagcgcct tccttgccca cctcactgcc     3540

acattccagt gggacggcca cggggggacc taggccccag ggaaagagcc ccatgccgcc     3600

ccctaaggag ccgcccagac ctagggctgg actcaggagc tgggggggcc tcacctgttc     3660

ccctgaggac cccgccggac ccggaggctc acagggaaca agacacggct gggttggata     3720

tgcctttgcc ggggttctgg ggcagggcgc tccctggccg cagcagatgc cctcccagga     3780

gtggaggggc tggagagggg gaggccttcg ggaagaggct tcctgggccc cctggtcttc     3840

ggccgggtcc ccagcccccg ctcctgcccc accccacctc ctccgggctt cctcccggaa     3900

actcagcgcc tgctgcactt gcctgccctg ccttgcttgg cacccgctcc ggcgaccctc     3960

cccgctcccc tgtcatttca tcgcggactg tgcggcctgg gggtgggggg cgggactctc     4020

acggtgacat gtttacagct gggtgtgact cagtaaagtg gatttttttt tc             4072


<210>  34
<211>  1117
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Glu Thr Phe Phe Arg Arg His Phe Arg Gly Lys Val Pro Gly Pro 
1               5                   10                  15      


Gly Glu Gly Gln Gln Arg Pro Ser Ser Val Gly Leu Pro Thr Gly Lys 
            20                  25                  30          


Ala Arg Arg Arg Ser Pro Ala Gly Gln Ala Ser Ser Ser Leu Ala Gln 
        35                  40                  45              


Arg Arg Arg Ser Ser Ala Gln Leu Gln Gly Cys Leu Leu Ser Cys Gly 
    50                  55                  60                  


Val Arg Ala Gln Gly Ser Ser Arg Arg Arg Ser Ser Thr Val Pro Pro 
65                  70                  75                  80  


Ser Cys Asn Pro Arg Phe Ile Val Asp Lys Val Leu Thr Pro Gln Pro 
                85                  90                  95      


Thr Thr Val Gly Ala Gln Leu Leu Gly Ala Pro Leu Leu Leu Thr Gly 
            100                 105                 110         


Leu Val Gly Met Asn Glu Glu Glu Gly Val Gln Glu Asp Val Val Ala 
        115                 120                 125             


Glu Ala Ser Ser Ala Ile Gln Pro Gly Thr Lys Thr Pro Gly Pro Pro 
    130                 135                 140                 


Pro Pro Arg Gly Ala Gln Pro Leu Leu Pro Leu Pro Arg Tyr Leu Arg 
145                 150                 155                 160 


Arg Ala Ser Ser His Leu Leu Pro Ala Asp Ala Val Tyr Asp His Ala 
                165                 170                 175     


Leu Trp Gly Leu His Gly Tyr Tyr Arg Arg Leu Ser Gln Arg Arg Pro 
            180                 185                 190         


Ser Gly Gln His Pro Gly Pro Gly Gly Arg Arg Ala Ser Gly Thr Thr 
        195                 200                 205             


Ala Gly Thr Met Leu Pro Thr Arg Val Arg Pro Leu Ser Arg Arg Arg 
    210                 215                 220                 


Gln Val Ala Leu Arg Arg Lys Ala Ala Gly Pro Gln Ala Trp Ser Ala 
225                 230                 235                 240 


Leu Leu Ala Lys Ala Ile Thr Lys Ser Gly Leu Gln His Leu Ala Pro 
                245                 250                 255     


Pro Pro Pro Thr Pro Gly Ala Pro Cys Ser Glu Ser Glu Arg Gln Ile 
            260                 265                 270         


Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Thr Tyr Gly Glu His Ile 
        275                 280                 285             


Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys Tyr Val Gly Glu Gln 
    290                 295                 300                 


Tyr Cys Val Ala Arg Met Leu Lys Ser Val Ser Arg Arg Lys Cys Ala 
305                 310                 315                 320 


Ala Cys Lys Ile Val Val His Thr Pro Cys Ile Glu Gln Leu Glu Lys 
                325                 330                 335     


Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg Glu Ser Gly Ser Arg Asn 
            340                 345                 350         


Val Arg Glu Pro Thr Phe Val Arg His His Trp Val His Arg Arg Arg 
        355                 360                 365             


Gln Asp Gly Lys Cys Arg His Cys Gly Lys Gly Phe Gln Gln Lys Phe 
    370                 375                 380                 


Thr Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys Ser Trp Cys Lys 
385                 390                 395                 400 


Gln Ala Tyr His Ser Lys Val Ser Cys Phe Met Leu Gln Gln Ile Glu 
                405                 410                 415     


Glu Pro Cys Ser Leu Gly Val His Ala Ala Val Val Ile Pro Pro Thr 
            420                 425                 430         


Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn Thr Leu Lys Ala Ser Lys 
        435                 440                 445             


Lys Lys Lys Arg Ala Ser Phe Lys Arg Lys Ser Ser Lys Lys Gly Pro 
    450                 455                 460                 


Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile Arg Pro Thr Pro Ser Pro 
465                 470                 475                 480 


Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys Ser Gly Gly Asn 
                485                 490                 495     


Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu Trp Tyr Leu Asn Pro Arg 
            500                 505                 510         


Gln Val Phe Asp Leu Ser Gln Gly Gly Pro Lys Glu Ala Leu Glu Met 
        515                 520                 525             


Tyr Arg Lys Val His Asn Leu Arg Ile Leu Ala Cys Gly Gly Asp Gly 
    530                 535                 540                 


Thr Val Gly Trp Ile Leu Ser Thr Leu Asp Gln Leu Arg Leu Lys Pro 
545                 550                 555                 560 


Pro Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala 
                565                 570                 575     


Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu Pro Val Ser Lys 
            580                 585                 590         


Ile Leu Ser His Val Glu Glu Gly Asn Val Val Gln Leu Asp Arg Trp 
        595                 600                 605             


Asp Leu His Ala Glu Pro Asn Pro Glu Ala Gly Pro Glu Asp Arg Asp 
    610                 615                 620                 


Glu Gly Ala Thr Asp Arg Leu Pro Leu Asp Val Phe Asn Asn Tyr Phe 
625                 630                 635                 640 


Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe His Glu Ser Arg 
                645                 650                 655     


Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg Asn Lys Met Phe 
            660                 665                 670         


Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu Met Gly Ser Ser Lys Asp 
        675                 680                 685             


Leu Ala Lys His Ile Arg Val Val Cys Asp Gly Met Asp Leu Thr Pro 
    690                 695                 700                 


Lys Ile Gln Asp Leu Lys Pro Gln Cys Val Val Phe Leu Asn Ile Pro 
705                 710                 715                 720 


Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly His Pro Gly Glu His His 
                725                 730                 735     


Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Leu Glu Val Ile Gly 
            740                 745                 750         


Phe Thr Met Thr Ser Leu Ala Ala Leu Gln Val Gly Gly His Gly Glu 
        755                 760                 765             


Arg Leu Thr Gln Cys Arg Glu Val Val Leu Thr Thr Ser Lys Ala Ile 
    770                 775                 780                 


Pro Val Gln Val Asp Gly Glu Pro Cys Lys Leu Ala Ala Ser Arg Ile 
785                 790                 795                 800 


Arg Ile Ala Leu Arg Asn Gln Ala Thr Met Val Gln Lys Ala Lys Arg 
                805                 810                 815     


Arg Ser Ala Ala Pro Leu His Ser Asp Gln Gln Pro Val Pro Glu Gln 
            820                 825                 830         


Leu Arg Ile Gln Val Ser Arg Val Ser Met His Asp Tyr Glu Ala Leu 
        835                 840                 845             


His Tyr Asp Lys Glu Gln Leu Lys Glu Ala Ser Val Pro Leu Gly Thr 
    850                 855                 860                 


Val Val Val Pro Gly Asp Ser Asp Leu Glu Leu Cys Arg Ala His Ile 
865                 870                 875                 880 


Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala Gly Ala Lys Ser Pro Thr 
                885                 890                 895     


Cys Gln Lys Leu Ser Pro Lys Trp Cys Phe Leu Asp Ala Thr Thr Ala 
            900                 905                 910         


Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln Glu His Leu Asn Tyr Val 
        915                 920                 925             


Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile Leu Asp Pro Glu Leu Leu 
    930                 935                 940                 


Gly Ala Ser Ala Arg Pro Asp Leu Pro Thr Pro Thr Ser Pro Leu Pro 
945                 950                 955                 960 


Thr Ser Pro Cys Ser Pro Thr Pro Arg Ser Leu Gln Gly Asp Ala Ala 
                965                 970                 975     


Pro Pro Gln Gly Glu Glu Leu Ile Glu Ala Ala Lys Arg Asn Asp Phe 
            980                 985                 990         


Cys Lys Leu Gln Glu Leu His Arg  Ala Gly Gly Asp Leu  Met His Arg 
        995                 1000                 1005             


Asp Glu  Gln Ser Arg Thr Leu  Leu His His Ala Val  Ser Thr Gly 
    1010                 1015                 1020             


Ser Lys  Asp Val Val Arg Tyr  Leu Leu Asp His Ala  Pro Pro Glu 
    1025                 1030                 1035             


Ile Leu  Asp Ala Val Glu Glu  Asn Gly Glu Thr Cys  Leu His Gln 
    1040                 1045                 1050             


Ala Ala  Ala Leu Gly Gln Arg  Thr Ile Cys His Tyr  Ile Val Glu 
    1055                 1060                 1065             


Ala Gly  Ala Ser Leu Met Lys  Thr Asp Gln Gln Gly  Asp Thr Pro 
    1070                 1075                 1080             


Arg Gln  Arg Ala Glu Lys Ala  Gln Asp Thr Glu Leu  Ala Ala Tyr 
    1085                 1090                 1095             


Leu Glu  Asn Arg Gln His Tyr  Gln Met Ile Gln Arg  Glu Asp Gln 
    1100                 1105                 1110             


Glu Thr  Ala Val 
    1115         


<210>  35
<211>  5605
<212>  DNA
<213>  Homo sapiens

<400>  35
ctttcccagg agagcccatg cgcagggcat ggatgaaagc aagctggaga gggagagagg       60

atgggaggcg aggaggcagc ctgagggaag gaacaggagg gaagagagat gaagggcaag      120

accggggcca gccatgcctg tcctaacagc agccacccag cagtggccca gcctgctgag      180

aactagaaaa tcagaagaaa aaggagaatc caccaggaga cccaggtaac tctgaagcgt      240

gagctgccag aattcaaggc cacctgctta acagaagaca actagaaacc tcatccatga      300

gcagagtgca gaccatgaat tacgtggggc agttagccgg ccaggtgttt gtcaccgtga      360

aggagctcta caaggggctg aatcccgcca cactctcagg gtgcattgac atcattgtca      420

tccgccagcc caatggaaac ctccaatgct cccctttcca cgtccgcttt gggaagatgg      480

gggtcctgcg ctcccgagag aaagtggttg acatagaaat caatggggaa tctgtggatt      540

tgcatatgaa attgggagat aatggagaag cattttttgt tcaagaaaca gataatgatc      600

aggaagttat ccctatgcac ctggccacct cccccatcct gtcagaagga gcttcgagaa      660

tggaatgcca gctgaaaagg ggctctgtgg acaggatgag aggcctggac cccagcacgc      720

cagcccaagt gatcgctccc agcgagacgc cgtcaagcag ctctgtagta aagaagagaa      780

gaaaaaggag gagaaagtca cagctggaca gcctgaagag agatgacaac atgaacacat      840

ctgaggatga ggacatgttc cccatcgaga tgagctcgga tgaggccatg gagctgctgg      900

agagcagcag aactcttcct aatgatatac ctccattcca agatgatatt cctgaggaaa      960

acctctccct ggctgtgatt taccctcagt cagcctcata ccctaattcg gatagagagt     1020

ggtcacccac tcccagtcct tccggttccc gaccttcaac acctaaaagt gattcagaat     1080

tggtcagcaa gtccacggaa aggacagggc agaagaaccc agaaatgctt tggctgtggg     1140

gagagctgcc gcaggctgct aagtcttctt ctccacacaa gatgaaagag tccagcccat     1200

tgagcagtag aaaaatttgt gataaaagtc actttcaggc cattcacagc gaatcttcag     1260

acacttttag tgaccaatcg ccaactctgg tcggtggggc acttttggac cagaacaagc     1320

ctcagacaga aatgcagttt gtgaatgaag aagacctgga gaccttagga gcagcagcgc     1380

cactcttgcc catgatcgag gagctcaaac ccccctctgc cagtgtagtc cagacagcaa     1440

acaagacgga ttctccttcc aggaaaagag ataaacgaag ccgacatctt ggtgctgacg     1500

gcgtctactt ggatgacctc acagacatgg atcctgaagt ggcggccctg tattttccca     1560

aaaacggaga tccttccgga ctcgcaaaac atgcaagcga caacggagcc cggtcagcca     1620

accagtcccc gcagtcggtg ggcagctcgg gcgtggacag tggcgtggag agcacctcgg     1680

acgggctgag ggacctccct tccatcgcca tctccctctg cgggggcctc agcgaccacc     1740

gggagatcac gaaagatgca ttcctggagc aagctgtgtc atatcaacag tttgtggaca     1800

accccgctat tatcgatgac cccaatctcg tggtaaagat tgggagtaaa tattataact     1860

ggacaacagc agcacccctc ctcctggcaa tgcaggcctt ccagaaacct ttgccaaagg     1920

ccactgtgga atctatcatg agggataaaa tgcccaaaaa gggaggaaga tggtggtttt     1980

catggagggg aagaaacacc acaatcaagg aggaaagtaa gccagagcag tgcttggctg     2040

gcaaggccca tagcaccgga gagcaaccgc cgcagctcag cttggccacc agggtaaagc     2100

atgaatcatc ctccagtgat gaggagcgcg cagctgccaa gccatcaaac gcaggccacc     2160

tccctcttct gcctaatgtc agctacaaga agactctccg gctgacttcc gagcagctta     2220

aaagcttgaa gttgaagaat ggccccaacg acgtggtttt cagtgtcacc acgcagtacc     2280

aaggcacgtg ccgctgtgag ggcaccatct atctgtggaa ctgggatgat aaagtcatca     2340

tttctgatat tgatgggaca attaccagat cagatactct tggccacatt ttgcccaccc     2400

ttgggaagga ttggacccat cagggcatcg ctaagctgta ccataaagtg agccagaatg     2460

gatataaatt tctctactgt tctgcccgtg ccatcgggat ggcggacatg acgcggggct     2520

acctgcactg ggtcaacgag aggggcacgg tgctgcccca ggggcccctg ctgctgagtc     2580

ccagcagcct cttctctgcc ctgcacagag aagtgattga aaagaagcca gaaaagttta     2640

aagtccagtg tttgacagac atcaaaaacc tgtttttccc caacacagaa cccttttatg     2700

ctgcttttgg aaaccgacca gctgatgtgt attcatacaa gcaagtagga gtgtctttga     2760

atagaatatt taccgtcaac cctaaaggag agctggtaca ggaacatgca aagaccaaca     2820

tctcttcgta tgtgagactc tgtgaagtag tcgaccacgt tttcccgttg ctgaaaagaa     2880

gccattcttc agactttccc tgttcggata ccttcagtaa cttcaccttt tggagagagc     2940

cactgccacc ttttgaaaac caggacattc attctgcctc agcgtaaaat gtcccaagca     3000

gcctcttgcc agcagtgcag agcctggttg tcacccatta aaggataggt ctccccggag     3060

tgcacagctc cacctgggag cctggcgcgt catcattggc ctgacagcag agagaattga     3120

gaagcatttc tcccctgccc caccccgggg ctgacatttc taagcaagat aggaagggag     3180

cactttctag gctaggagtt gggtgcattt gtaccgtgaa aagcattcct cagttgtggc     3240

ttaatgccag ttacgacgct gcctttccgg cctgctccag caagtagcta ctggttcacg     3300

tgcagtttgg ggctgtgaaa cctaggcaga aggcggctgt ctgagggctg tccccgccta     3360

ggacagggtc aatcgaggaa tgccagatgt gcacggtttt tggcaaagta gggggcacat     3420

ttccattata gcaatgttag tgccaccacc ttctgaacac agtggggagg gctgtgaagg     3480

ctcatgtgac ctggatctga ggtctctgat agaaatctgg acgccaccgg gtccaggcct     3540

ggcctcagac ttggccttgt ggatgggccc cttacagtat ttgctgacta gtctcatttt     3600

taggtgataa atttttcttt aattcctttg gttaaagata gtctatttca ttggcatatc     3660

tccccccagt ttttgtggct caaggctgga atatttatgc cttaatatat ctatggcaga     3720

catttaagaa tgcgctttat ctagctcatg gtaactttgc aacgccttag attaaaatga     3780

cagtaaatat tactaaggca gtattttgaa tgagtttgac actgccggct tccttccatc     3840

cagcgaggtg gtgctgacag tgtggacttg agcacactta tgccaaatga taatgatact     3900

gacttctgtt gggagctctc caaagaaact ggttggtttt aagaaaatag tttcaagaag     3960

ttcaactata ttcttttaga tattatgtat tgttttactc tgattaggtt actgtgatag     4020

gcatttattc atattctttc tataccactg tcattaatat attaaaaaga tgtatgtgtt     4080

agactatcga aagggcctta ttctctcttt ctcatagact gaccttcttt tggaatttct     4140

gagtcattta ttttccttag ctttttccac tcaaattaag ggcaagcgaa aaagtaataa     4200

tttggcattc tttaagccta cagaatgtga ttctttcact tgtttattac actggctcgt     4260

ggacagaaca atttgaaaag tgaaagaatt attttggtaa aagattttgc tttacttttc     4320

gaagcattat ttttttaaag agtgttttac tccaacgatt gaaacatttt cctatttaaa     4380

tttcattgtt agaatcacag gaggcaaaaa atggaacggt tgaatgaaat tttactcttt     4440

ctgtgaaaga aaatccacag agttgttgcc tccgttgtag ttggtgggcc ccgttagcat     4500

tggatgcctt tgccaaatgg ttcatgtgga cacacaaagg caaacagatc tgccatcgat     4560

cgcagatttc tgtagaaaca cggatgtgca tgtgcagatt cccttttgca ggtattaaaa     4620

ataattaaaa atagtcctgc ctgaggttgc agtgagccga gcttgcacta ctgcactcca     4680

gcctgggtga cagagtaaga ctccatgtca aaaaaaaaaa aaaaaaaaaa aaagtcctgc     4740

cttaactaac tcctctgcgc ttgttcacta gtaacctaaa gaggctatat tcattcttta     4800

tgcaatgagg gtatttttga gtgaatttta actgctctga actaagtata agctcatggg     4860

cctgcaaagg ttcagacggt ttctcctttg cacccaggag gaactttggc tgcgagaatg     4920

gggggatgta tccctcatgc agttggcatc caggcagccc tctgcagcag cacaccctgc     4980

aggcggagtt ttcagaggat gcaattttgg atcccgaatt ttgatgtacc ttaaacttcc     5040

acatcactgc accctgaaac agagcatgct ttccagaaag tcacactctc agatctgtgt     5100

caagttcaat gtgagccctg gcaaggctgg catattaaca cctgccttct ggcttctgaa     5160

agtgagattt gtatatgggc tgcactcacg catatacgag ttggtttatc tttgtgtaca     5220

tgactataac ccagtgatgc tgaggtcatg tgctggaatg ctgtatttgg accacacatt     5280

tcaaagttgc cctatggaaa tgaatcctac ttagtgacaa gtcatcaaat gtttgtcaca     5340

tgtgatgaag acaaatatgt atacctggca tagagaaaaa tatatacctg gtacattgga     5400

gaaaaataat tacactttca aagagaattc cctttgcaat tttatgtttg gatcaccact     5460

gtaagcacac tttatttgca tttgatctgt atttgtatat gctgatgcaa tgataaaaat     5520

cactgtaata cttcattgtg ttgtactgga tgcaaagcta gaaaatattg caataaatga     5580

gaccgatgaa agacttctct gaaaa                                           5605


<210>  36
<211>  896
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ser Arg Val Gln Thr Met Asn Tyr Val Gly Gln Leu Ala Gly Gln 
1               5                   10                  15      


Val Phe Val Thr Val Lys Glu Leu Tyr Lys Gly Leu Asn Pro Ala Thr 
            20                  25                  30          


Leu Ser Gly Cys Ile Asp Ile Ile Val Ile Arg Gln Pro Asn Gly Asn 
        35                  40                  45              


Leu Gln Cys Ser Pro Phe His Val Arg Phe Gly Lys Met Gly Val Leu 
    50                  55                  60                  


Arg Ser Arg Glu Lys Val Val Asp Ile Glu Ile Asn Gly Glu Ser Val 
65                  70                  75                  80  


Asp Leu His Met Lys Leu Gly Asp Asn Gly Glu Ala Phe Phe Val Gln 
                85                  90                  95      


Glu Thr Asp Asn Asp Gln Glu Val Ile Pro Met His Leu Ala Thr Ser 
            100                 105                 110         


Pro Ile Leu Ser Glu Gly Ala Ser Arg Met Glu Cys Gln Leu Lys Arg 
        115                 120                 125             


Gly Ser Val Asp Arg Met Arg Gly Leu Asp Pro Ser Thr Pro Ala Gln 
    130                 135                 140                 


Val Ile Ala Pro Ser Glu Thr Pro Ser Ser Ser Ser Val Val Lys Lys 
145                 150                 155                 160 


Arg Arg Lys Arg Arg Arg Lys Ser Gln Leu Asp Ser Leu Lys Arg Asp 
                165                 170                 175     


Asp Asn Met Asn Thr Ser Glu Asp Glu Asp Met Phe Pro Ile Glu Met 
            180                 185                 190         


Ser Ser Asp Glu Ala Met Glu Leu Leu Glu Ser Ser Arg Thr Leu Pro 
        195                 200                 205             


Asn Asp Ile Pro Pro Phe Gln Asp Asp Ile Pro Glu Glu Asn Leu Ser 
    210                 215                 220                 


Leu Ala Val Ile Tyr Pro Gln Ser Ala Ser Tyr Pro Asn Ser Asp Arg 
225                 230                 235                 240 


Glu Trp Ser Pro Thr Pro Ser Pro Ser Gly Ser Arg Pro Ser Thr Pro 
                245                 250                 255     


Lys Ser Asp Ser Glu Leu Val Ser Lys Ser Thr Glu Arg Thr Gly Gln 
            260                 265                 270         


Lys Asn Pro Glu Met Leu Trp Leu Trp Gly Glu Leu Pro Gln Ala Ala 
        275                 280                 285             


Lys Ser Ser Ser Pro His Lys Met Lys Glu Ser Ser Pro Leu Ser Ser 
    290                 295                 300                 


Arg Lys Ile Cys Asp Lys Ser His Phe Gln Ala Ile His Ser Glu Ser 
305                 310                 315                 320 


Ser Asp Thr Phe Ser Asp Gln Ser Pro Thr Leu Val Gly Gly Ala Leu 
                325                 330                 335     


Leu Asp Gln Asn Lys Pro Gln Thr Glu Met Gln Phe Val Asn Glu Glu 
            340                 345                 350         


Asp Leu Glu Thr Leu Gly Ala Ala Ala Pro Leu Leu Pro Met Ile Glu 
        355                 360                 365             


Glu Leu Lys Pro Pro Ser Ala Ser Val Val Gln Thr Ala Asn Lys Thr 
    370                 375                 380                 


Asp Ser Pro Ser Arg Lys Arg Asp Lys Arg Ser Arg His Leu Gly Ala 
385                 390                 395                 400 


Asp Gly Val Tyr Leu Asp Asp Leu Thr Asp Met Asp Pro Glu Val Ala 
                405                 410                 415     


Ala Leu Tyr Phe Pro Lys Asn Gly Asp Pro Ser Gly Leu Ala Lys His 
            420                 425                 430         


Ala Ser Asp Asn Gly Ala Arg Ser Ala Asn Gln Ser Pro Gln Ser Val 
        435                 440                 445             


Gly Ser Ser Gly Val Asp Ser Gly Val Glu Ser Thr Ser Asp Gly Leu 
    450                 455                 460                 


Arg Asp Leu Pro Ser Ile Ala Ile Ser Leu Cys Gly Gly Leu Ser Asp 
465                 470                 475                 480 


His Arg Glu Ile Thr Lys Asp Ala Phe Leu Glu Gln Ala Val Ser Tyr 
                485                 490                 495     


Gln Gln Phe Val Asp Asn Pro Ala Ile Ile Asp Asp Pro Asn Leu Val 
            500                 505                 510         


Val Lys Ile Gly Ser Lys Tyr Tyr Asn Trp Thr Thr Ala Ala Pro Leu 
        515                 520                 525             


Leu Leu Ala Met Gln Ala Phe Gln Lys Pro Leu Pro Lys Ala Thr Val 
    530                 535                 540                 


Glu Ser Ile Met Arg Asp Lys Met Pro Lys Lys Gly Gly Arg Trp Trp 
545                 550                 555                 560 


Phe Ser Trp Arg Gly Arg Asn Thr Thr Ile Lys Glu Glu Ser Lys Pro 
                565                 570                 575     


Glu Gln Cys Leu Ala Gly Lys Ala His Ser Thr Gly Glu Gln Pro Pro 
            580                 585                 590         


Gln Leu Ser Leu Ala Thr Arg Val Lys His Glu Ser Ser Ser Ser Asp 
        595                 600                 605             


Glu Glu Arg Ala Ala Ala Lys Pro Ser Asn Ala Gly His Leu Pro Leu 
    610                 615                 620                 


Leu Pro Asn Val Ser Tyr Lys Lys Thr Leu Arg Leu Thr Ser Glu Gln 
625                 630                 635                 640 


Leu Lys Ser Leu Lys Leu Lys Asn Gly Pro Asn Asp Val Val Phe Ser 
                645                 650                 655     


Val Thr Thr Gln Tyr Gln Gly Thr Cys Arg Cys Glu Gly Thr Ile Tyr 
            660                 665                 670         


Leu Trp Asn Trp Asp Asp Lys Val Ile Ile Ser Asp Ile Asp Gly Thr 
        675                 680                 685             


Ile Thr Arg Ser Asp Thr Leu Gly His Ile Leu Pro Thr Leu Gly Lys 
    690                 695                 700                 


Asp Trp Thr His Gln Gly Ile Ala Lys Leu Tyr His Lys Val Ser Gln 
705                 710                 715                 720 


Asn Gly Tyr Lys Phe Leu Tyr Cys Ser Ala Arg Ala Ile Gly Met Ala 
                725                 730                 735     


Asp Met Thr Arg Gly Tyr Leu His Trp Val Asn Glu Arg Gly Thr Val 
            740                 745                 750         


Leu Pro Gln Gly Pro Leu Leu Leu Ser Pro Ser Ser Leu Phe Ser Ala 
        755                 760                 765             


Leu His Arg Glu Val Ile Glu Lys Lys Pro Glu Lys Phe Lys Val Gln 
    770                 775                 780                 


Cys Leu Thr Asp Ile Lys Asn Leu Phe Phe Pro Asn Thr Glu Pro Phe 
785                 790                 795                 800 


Tyr Ala Ala Phe Gly Asn Arg Pro Ala Asp Val Tyr Ser Tyr Lys Gln 
                805                 810                 815     


Val Gly Val Ser Leu Asn Arg Ile Phe Thr Val Asn Pro Lys Gly Glu 
            820                 825                 830         


Leu Val Gln Glu His Ala Lys Thr Asn Ile Ser Ser Tyr Val Arg Leu 
        835                 840                 845             


Cys Glu Val Val Asp His Val Phe Pro Leu Leu Lys Arg Ser His Ser 
    850                 855                 860                 


Ser Asp Phe Pro Cys Ser Asp Thr Phe Ser Asn Phe Thr Phe Trp Arg 
865                 870                 875                 880 


Glu Pro Leu Pro Pro Phe Glu Asn Gln Asp Ile His Ser Ala Ser Ala 
                885                 890                 895     


<210>  37
<211>  6245
<212>  DNA
<213>  Homo sapiens

<400>  37
gagaagaagt ggcaggtgat gctgaagcgg gggagaagcg gcagagccgg ccacacagtg       60

caggggatgg agacaggtgc tgggctggtc ctcctgcagc atcctcagtt gttggagggc      120

agtcatcctc aggccgtacc cagccagaga agaaaaagaa cagtgtgaag ccacgtgtga      180

tagccgtcca acatcggctc ttccctccaa ttacattgta gttgattgtg tctcaaacca      240

tgaattatgt gggacagctg gctgggcagg tgattgtcac tgtgaaggaa ctctacaagg      300

gcattaacca ggccaccctc tctgggtgca ttgatgtcat cgtggtacag cagcaggatg      360

gcagctatca gtgttcacct tttcacgttc ggtttggaaa gctgggagtc ctgagatcca      420

aagagaaagt gattgatata gaaatcaacg gcagtgcagt ggatcttcac atgaagttgg      480

gtgataacgg agaagctttc tttgttgagg agactgaaga agaatatgaa aagcttcctg      540

cttaccttgc cacctcacca attcctactg aagatcagtt ctttaaagat attgacaccc      600

ctttggtgaa atcgggtgga gatgaaacac catctcagag ttcagacatc tcacacgtct      660

tggaaacaga gacaattttt actccaagtt ctgtgaaaaa gaaaaaacga aggagaaaga      720

aatacaaaca ggacagtaag aaggaagagc aggccgcatc tgctgctgca gaagacacat      780

gtgatgtagg cgtgagctcc gatgatgaca agggggccca ggcagcacga ggatcttcaa      840

atgcttcctt gaaagaagaa gaatgtaaag agcctttgct cttccattct ggggatcatt      900

accccttatc tgatggagat tggtcccctt tagagaccac ctatccccag acagcgtgtc      960

ctaagagtga ttcagagctg gaggtgaaac ctgcggagag cctgctcaga tcagagtctc     1020

acatggagtg gacgtggggc ggattcccag agtccaccaa ggtcagcaaa agagaacgat     1080

ctgaccatca tcctaggaca gctacaatta caccatcaga aaatactcat tttcgggtaa     1140

ttcccagtga ggacaacctc atcagtgaag ttgagaagga tgcttccatg gaagacactg     1200

tctgtaccat agtgaagccc aaacccagag ccctgggtac acagatgagc gacccaacat     1260

ctgtggcaga gcttctcgaa cctcctcttg agagtactca gatttcatct atgttagatg     1320

ctgaccacct tcccaacgca gccttagcgg aggcgccctc agaatccaaa ccggcagcta     1380

aagtagactc gccgtcaaag aagaaaggtg ttcacaaaag aagccaacac cagggacctg     1440

atgatattta ccttgatgac ttaaagggtc tagaacctga agttgcagct ctttatttcc     1500

ctaaaagtga atcggagccc ggttccaggc agtggcccga gtctgacaca ctctctggct     1560

cccagtcccc acagtccgtg ggaagcgcag ctgcagatag cggcaccgag tgcctctcag     1620

attctgccat ggacttgcct gacgttaccc tctccctttg cgggggcctc agtgaaaatg     1680

gagaaatttc aaaagaaaaa ttcatggagc atatcattac ttatcacgaa tttgcagaaa     1740

accctggact tatagacaat cctaaccttg taataaggat atataatcgt tactataact     1800

gggctttggc agctcccatg atccttagct tgcaagtatt ccagaagagc ttgcctaagg     1860

ccacagttga gtcctgggtg aaagacaaga tgccaaagaa atctggtcgc tggtggtttt     1920

ggcgaaagag agaaagcatg accaaacagc tgccagaatc caaggaggga aaatctgagg     1980

caccgccagc cagtgacctg ccatccagct ccaaggagcc ggccggtgcc aggccggccg     2040

agaatgactc ctcgagtgac gagggatcac aggagctcga agaatccatc acagtggacc     2100

ccatccccac agagcccctg agccacggca gcacaacttc atataagaag tctctccgcc     2160

tctcctcaga ccagatcgca aaactgaagc tccacgatgg cccaaatgat gttgtgttta     2220

gtattacaac ccagtatcaa ggcacctgtc gctgtgcagg gaccatttac ctgtggaact     2280

ggaatgacaa gatcatcatt tctgatattg atgggacaat aaccaagtcg gatgctttgg     2340

gacagattct cccacagctg ggcaaagact ggacccacca gggtatagca aagctctacc     2400

attccatcaa tgagaatggc tacaagtttc tgtactgctc ggctcgtgcc atcggcatgg     2460

ccgacatgac ccgtggctac ctgcactggg tcaatgacaa gggcacaatc ttgccccggg     2520

gccccctgat gctgtccccc agcagcttgt tctccgcctt ccacagagaa gtgatagaaa     2580

agaaaccaga gaagttcaaa attgagtgtc taaatgatat caagaatctg tttgccccgt     2640

ctaagcagcc cttctatgct gcctttggaa accgtccaaa tgatgtctat gcctacacac     2700

aagttggagt tccagactgt agaatattca ccgtgaaccc caagggtgaa ttaatacaag     2760

aaagaaccaa aggaaacaag tcatcgtatc acaggctgag tgagctcgtg gagcatgtgt     2820

tcccccttct cagtaaggag cagaattccg cttttccctg cccggagttc agctccttct     2880

gctactggcg agacccgatc cctgaagtgg acctggatga cctgtcttga ggcggcacct     2940

cagtgggtgg gcagggcttg gtccccctcc ccacagcaag ggaaggcagc tggctcttct     3000

gctgacctca gataccagcc ttccccagcg gggacgggtg cttctggagc tggtcccgcc     3060

atcctccttt gccttcccag gccagctgct caggctcggc aggtctgcag ctcagctcct     3120

ggaaggagaa gggaggaact gggcctgggg ctggaggcct gggatccctc ctttgtgggt     3180

cgcacacatg tttcctgctg tgagctgggg cctccttcca ttgcatcatt ttaaaggaag     3240

aaaaaagcag ctaaaaaaga gtggaccaaa acactgcaca cagtgaagtg ttccagtttc     3300

cactgggcag ttgaggtggc ttctgtaacc agggctgtct tcagatgtca gggtccctga     3360

actgctgcgg gcccagtcag tgatgctggc tgaagctgcc tgtgcacgtt tcttctctgg     3420

tcgcctcatt tcctgctaca ctgaaggggt cagctgctcc agtgggccaa gttgggcagg     3480

acccccgccc ctgcagggcc catgcaccag agccactgag cccagtccca taaacctggc     3540

cctctttggg gaaagatccc cacagagcat cctcctctca tctgtgacaa ctccacgagc     3600

ccttaatttc ttagtcctca ccagaagaac aggtctcaca agtatatatt tgatgtctgt     3660

aataaaagtg ggaaggtggg tcttaaaaca gaccaaaccc cgccccgccc ccaacaactc     3720

tgcttttagg gaggcctccg aaatgcagat aggcggttga gtggggtcct gggaagagcg     3780

ctgaatccct ctgcttgctg cctggtgtgg gcctttggaa agcatcttgc cttgggacag     3840

gatttctaaa attctgtgat tcagatttgt cagggaagca cagtgaagct tgcttaaagg     3900

cactggccag cagtgtgtga ctttggcttt tgggatcaca ccctgtaatc gggcccgtgg     3960

aagcagcgtc aaagaggggt cttggagctc ctatggagca gactgccccc cgagcagtgt     4020

ccccagccta gccctgtgag accccatggg gacacgggtg cctatgtatt ttcactaaaa     4080

tatacatggt agctccattt actgatgcgg ttgtaatgag ctcacatcgt gtctgaagag     4140

atggcaccag ggaaaggtgt gccataagct gctccagagc ttttggtatg ctgagtgttg     4200

acagagctgc actcttaaca tcaagagaac tgtcaggagc ccagaaccaa ccccaggtct     4260

tggtctccat tggcgagaac acaggacgtg gtggttcctg agcagagagg gatctgcaga     4320

tacaggcttg gcgctcgggg tggtctcgtg gccaactctt catgcccctg ccgttgtagt     4380

ggaacctcta catgttttag tttgcttcac ctaaaataat gctgatctag agatagagaa     4440

ataggggtgg ttatttttcc agattggaga gttgaaagtc cctgactgat ttcagccatt     4500

ttcctagtgc ttgtcggatg cagagacaat gttgaaatcc cctaaacaca gttctcagtg     4560

gcaaaaccta ggaaggctca tgttcccaga gaagggacca catgagcctt ctcccatgca     4620

aagcttcccc cagcttaaat agttgataag gactaattgt ttaatgagtt tatttatcta     4680

cagtaggtta gggatcctgg gttctgttta tatgaagttc ttcccagttt gtgaattcta     4740

gtacagcagc catgcagcca ccttatttca tagatgccat ctgtgtgtcc tcttgactac     4800

cttctattta gaggaagaat gagagctttg tgtgtttaac tgagcttata gtaggacttc     4860

tttgcatatg tatggtactg aaaaatctta atatacatct ttaatccttt ttaggttgtc     4920

ctttaaagag tttttgacta gtttcttttt cttgacagct cttctctttg gacacatggg     4980

ccttcttaga gggttcagtc taggacccgg ctctcctggc cctgtgttga gggtagctgg     5040

tccctctgtc cctgtgtctg ctagcactag actttgttgc tgcagattga tccagtgggt     5100

acataggcta attaatgtga gtctttttcc ttgtttaaag gagtccctct tgctgaaagt     5160

agatgattac tattgctgta gtgttaggaa agtattaagt ttgtgctgaa aatccattgc     5220

catttggtac aaatgacatt tgttctttct gtgaaagaga tgccctcgag tgtgtttgta     5280

cacaaaccct taggatggtg agttgaagca tcaccctcgc gctatcttca gtgacgggtg     5340

acggctcagg gagatggcag gcagattggg ctctaagtca ttattctctc agttactcca     5400

ttggtgaaat ggccctttcc ctctttgcag ttcagtctaa gtctcgtatt tgctttgctg     5460

tctgtgtgct gaagctcgtc ccgtgtgagt tgctgtctgc cccttgtcag gctgtgaggt     5520

gctcgtgtag acctggagca tgcaggctgc ctccgttttt gggtactgtg ttgtgttttg     5580

ctctgtctaa aaacatctgc atagttttca actggaaaaa gaaaaaactt aaaaatggga     5640

tgtcctaaaa tgaaagctgc tcaaagtcac agaacaaccg agggacaaag gagattggat     5700

gactgggaag cgctggcccg gaacagcccc tgcaactgtg gggcctgcac acagcccttc     5760

cacagttggc actgcaggtg caggccaacc ctttaaagaa taaacaagga agtcagctct     5820

ttcacttttt acaagttggc aaaaacagac ttccggggaa tttcgatgtt ttcccgtgtt     5880

gtagagcttc cagggtttaa taaaactggt taaaaattga gtctttccct gaagtaagtg     5940

ctctttccag atgaaaacta ctcttttggt tttgtttgaa agtaagaaag ggaggggaaa     6000

ctttgctctt ttaataatta tgttcagcct atgatgaagt atttgattat tagacagcaa     6060

tgtcactaat aagttttaag ttgtccaaag ttaattgtaa acatcatcag tacagtactc     6120

ttagttacag taaagcaatt gttgcaagat gaatggctaa tattttggtg cagtgtttga     6180

tgttcaaaac aaaatgttac aacaataaac gaacataaca taaactgaaa aaaaaaaaaa     6240

aaaaa                                                                 6245


<210>  38
<211>  896
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Asn Tyr Val Gly Gln Leu Ala Gly Gln Val Ile Val Thr Val Lys 
1               5                   10                  15      


Glu Leu Tyr Lys Gly Ile Asn Gln Ala Thr Leu Ser Gly Cys Ile Asp 
            20                  25                  30          


Val Ile Val Val Gln Gln Gln Asp Gly Ser Tyr Gln Cys Ser Pro Phe 
        35                  40                  45              


His Val Arg Phe Gly Lys Leu Gly Val Leu Arg Ser Lys Glu Lys Val 
    50                  55                  60                  


Ile Asp Ile Glu Ile Asn Gly Ser Ala Val Asp Leu His Met Lys Leu 
65                  70                  75                  80  


Gly Asp Asn Gly Glu Ala Phe Phe Val Glu Glu Thr Glu Glu Glu Tyr 
                85                  90                  95      


Glu Lys Leu Pro Ala Tyr Leu Ala Thr Ser Pro Ile Pro Thr Glu Asp 
            100                 105                 110         


Gln Phe Phe Lys Asp Ile Asp Thr Pro Leu Val Lys Ser Gly Gly Asp 
        115                 120                 125             


Glu Thr Pro Ser Gln Ser Ser Asp Ile Ser His Val Leu Glu Thr Glu 
    130                 135                 140                 


Thr Ile Phe Thr Pro Ser Ser Val Lys Lys Lys Lys Arg Arg Arg Lys 
145                 150                 155                 160 


Lys Tyr Lys Gln Asp Ser Lys Lys Glu Glu Gln Ala Ala Ser Ala Ala 
                165                 170                 175     


Ala Glu Asp Thr Cys Asp Val Gly Val Ser Ser Asp Asp Asp Lys Gly 
            180                 185                 190         


Ala Gln Ala Ala Arg Gly Ser Ser Asn Ala Ser Leu Lys Glu Glu Glu 
        195                 200                 205             


Cys Lys Glu Pro Leu Leu Phe His Ser Gly Asp His Tyr Pro Leu Ser 
    210                 215                 220                 


Asp Gly Asp Trp Ser Pro Leu Glu Thr Thr Tyr Pro Gln Thr Ala Cys 
225                 230                 235                 240 


Pro Lys Ser Asp Ser Glu Leu Glu Val Lys Pro Ala Glu Ser Leu Leu 
                245                 250                 255     


Arg Ser Glu Ser His Met Glu Trp Thr Trp Gly Gly Phe Pro Glu Ser 
            260                 265                 270         


Thr Lys Val Ser Lys Arg Glu Arg Ser Asp His His Pro Arg Thr Ala 
        275                 280                 285             


Thr Ile Thr Pro Ser Glu Asn Thr His Phe Arg Val Ile Pro Ser Glu 
    290                 295                 300                 


Asp Asn Leu Ile Ser Glu Val Glu Lys Asp Ala Ser Met Glu Asp Thr 
305                 310                 315                 320 


Val Cys Thr Ile Val Lys Pro Lys Pro Arg Ala Leu Gly Thr Gln Met 
                325                 330                 335     


Ser Asp Pro Thr Ser Val Ala Glu Leu Leu Glu Pro Pro Leu Glu Ser 
            340                 345                 350         


Thr Gln Ile Ser Ser Met Leu Asp Ala Asp His Leu Pro Asn Ala Ala 
        355                 360                 365             


Leu Ala Glu Ala Pro Ser Glu Ser Lys Pro Ala Ala Lys Val Asp Ser 
    370                 375                 380                 


Pro Ser Lys Lys Lys Gly Val His Lys Arg Ser Gln His Gln Gly Pro 
385                 390                 395                 400 


Asp Asp Ile Tyr Leu Asp Asp Leu Lys Gly Leu Glu Pro Glu Val Ala 
                405                 410                 415     


Ala Leu Tyr Phe Pro Lys Ser Glu Ser Glu Pro Gly Ser Arg Gln Trp 
            420                 425                 430         


Pro Glu Ser Asp Thr Leu Ser Gly Ser Gln Ser Pro Gln Ser Val Gly 
        435                 440                 445             


Ser Ala Ala Ala Asp Ser Gly Thr Glu Cys Leu Ser Asp Ser Ala Met 
    450                 455                 460                 


Asp Leu Pro Asp Val Thr Leu Ser Leu Cys Gly Gly Leu Ser Glu Asn 
465                 470                 475                 480 


Gly Glu Ile Ser Lys Glu Lys Phe Met Glu His Ile Ile Thr Tyr His 
                485                 490                 495     


Glu Phe Ala Glu Asn Pro Gly Leu Ile Asp Asn Pro Asn Leu Val Ile 
            500                 505                 510         


Arg Ile Tyr Asn Arg Tyr Tyr Asn Trp Ala Leu Ala Ala Pro Met Ile 
        515                 520                 525             


Leu Ser Leu Gln Val Phe Gln Lys Ser Leu Pro Lys Ala Thr Val Glu 
    530                 535                 540                 


Ser Trp Val Lys Asp Lys Met Pro Lys Lys Ser Gly Arg Trp Trp Phe 
545                 550                 555                 560 


Trp Arg Lys Arg Glu Ser Met Thr Lys Gln Leu Pro Glu Ser Lys Glu 
                565                 570                 575     


Gly Lys Ser Glu Ala Pro Pro Ala Ser Asp Leu Pro Ser Ser Ser Lys 
            580                 585                 590         


Glu Pro Ala Gly Ala Arg Pro Ala Glu Asn Asp Ser Ser Ser Asp Glu 
        595                 600                 605             


Gly Ser Gln Glu Leu Glu Glu Ser Ile Thr Val Asp Pro Ile Pro Thr 
    610                 615                 620                 


Glu Pro Leu Ser His Gly Ser Thr Thr Ser Tyr Lys Lys Ser Leu Arg 
625                 630                 635                 640 


Leu Ser Ser Asp Gln Ile Ala Lys Leu Lys Leu His Asp Gly Pro Asn 
                645                 650                 655     


Asp Val Val Phe Ser Ile Thr Thr Gln Tyr Gln Gly Thr Cys Arg Cys 
            660                 665                 670         


Ala Gly Thr Ile Tyr Leu Trp Asn Trp Asn Asp Lys Ile Ile Ile Ser 
        675                 680                 685             


Asp Ile Asp Gly Thr Ile Thr Lys Ser Asp Ala Leu Gly Gln Ile Leu 
    690                 695                 700                 


Pro Gln Leu Gly Lys Asp Trp Thr His Gln Gly Ile Ala Lys Leu Tyr 
705                 710                 715                 720 


His Ser Ile Asn Glu Asn Gly Tyr Lys Phe Leu Tyr Cys Ser Ala Arg 
                725                 730                 735     


Ala Ile Gly Met Ala Asp Met Thr Arg Gly Tyr Leu His Trp Val Asn 
            740                 745                 750         


Asp Lys Gly Thr Ile Leu Pro Arg Gly Pro Leu Met Leu Ser Pro Ser 
        755                 760                 765             


Ser Leu Phe Ser Ala Phe His Arg Glu Val Ile Glu Lys Lys Pro Glu 
    770                 775                 780                 


Lys Phe Lys Ile Glu Cys Leu Asn Asp Ile Lys Asn Leu Phe Ala Pro 
785                 790                 795                 800 


Ser Lys Gln Pro Phe Tyr Ala Ala Phe Gly Asn Arg Pro Asn Asp Val 
                805                 810                 815     


Tyr Ala Tyr Thr Gln Val Gly Val Pro Asp Cys Arg Ile Phe Thr Val 
            820                 825                 830         


Asn Pro Lys Gly Glu Leu Ile Gln Glu Arg Thr Lys Gly Asn Lys Ser 
        835                 840                 845             


Ser Tyr His Arg Leu Ser Glu Leu Val Glu His Val Phe Pro Leu Leu 
    850                 855                 860                 


Ser Lys Glu Gln Asn Ser Ala Phe Pro Cys Pro Glu Phe Ser Ser Phe 
865                 870                 875                 880 


Cys Tyr Trp Arg Asp Pro Ile Pro Glu Val Asp Leu Asp Asp Leu Ser 
                885                 890                 895     


<210>  39
<211>  4465
<212>  DNA
<213>  Homo sapiens

<400>  39
agattggggc ctgtggaggc cgcactagga tcgtagaagg agtggagccg tgctctcacc       60

ctgtcttaga ggacccggaa gcgccaagtg actgagggcc gaagacactc acctgtggag      120

cctgtgcacg taggtagagg cggcggctct gagtccagga gctccagtgg gcagctcccc      180

agcaccagcc atgaactacg tggggcagct ggcggagacg gtgtttggga cggtgaagga      240

gctgtaccgg ggcctgaacc cagccacact gagcggcggc attgacgtgc tggtggtgaa      300

gcaggtggac ggctcgttcc ggtgctcacc cttccacgtg cgttttggca agctgggcgt      360

cctgcggtcg cgggagaagg tggtagacat tgagctcaat ggggagcctg tggacttgca      420

catgaagctt ggggacagcg gggaggcctt ctttgttcag gagctggaga gcgatgatga      480

acatgtgcct cccggcctgt gcacctcacc catcccttgg gggggtctgt ctggcttccc      540

ctcggactcc cagctgggca ctgccagtga gcctgagggc ctcgtcatgg caggcacggc      600

ctccactggg cggaggaaga ggcgtcgcag gaggaaaccc aagcagaaag aggatgcagt      660

ggcaactgat tctagtccag aggaactgga ggcaggcgct gagagtgagc tatccctgcc      720

ggaaaagctg aggccagagc ccccaggcag tgtccagttg gaagagaagt cttcactgca      780

gcccaaagac atctacccct actcggatgg cgagtggccc ccccaggcca gcctctcagc      840

aggtgagcta acatccccta agagcgactc ggagctggag gtgcggaccc cggagcccag      900

tcccctaaga gccgagtccc acatgcagtg ggcctggggg aggctgccta aggtggccag      960

agctgagcgg cccgagtcct cagtggtcct tgaaggcaga gctggggcaa cctctcctcc     1020

tcggggagga cccagcactc cctctacctc tgtggctggc ggcgtggacc ctttgggact     1080

cccaatccag caaacagagg ctggtgccga ccttcagcct gacacagagg atcccactct     1140

agtgggtccc cctctccaca ccccagagac agaggaaagc aagactcaga gctctgggga     1200

catgggcctc cctcctgcct ccaagtcatg gagctgggcc actctggagg ttccagttcc     1260

caccgggcag ccagagaggg tctccagggg gaaaggctcc ccaaagagaa gccagcacct     1320

gggccccagt gacatctacc tggatgactt gccctccctg gactctgaga atgcagcgct     1380

ttacttcccc caaagtgact ctgggctggg ggccagaaga tggagtgaac ccagcagtca     1440

gaagtccctg agggacccca accctgaaca tgaacctgaa cccactctgg acacagtgga     1500

tacaatagca ctgtccctct gtggtggact ggctgacagc cgggacatct ccctagagaa     1560

attcaaccag cacagcgtct cttaccagga cctcaccaaa aaccccggac ttttggatga     1620

cccaaaccta gtggtgaaaa tcaatggaaa gcattataac tgggctgtgg ctgcccccat     1680

gatcctctcc ctgcaagcct tccagaaaaa cttgcccaag agcaccatgg acaagctgga     1740

gagggagaag atgccccgga agggtgggcg atggtggttt tcctggcgac gcagggactt     1800

cctggccgag gagcgcagtg cccagaagga gaagactgca gccaaggagc agcaggggga     1860

gaagacagaa gtcctgagca gtgatgacga tgccccagac agccctgtga tcctggagat     1920

cccctccttg ccaccctcca ctccaccctc cactcctacc tacaagaagt ccctccgcct     1980

ctcctccgat cagatccggc gcctgaacct gcaagaaggt gccaatgatg tggtcttcag     2040

cgtgaccact cagtaccagg gcacctgccg ctgcaaggcc accatctacc tgtggaaatg     2100

ggacgacaag gtggtcatct ctgacatcga cggcaccatc accaagtcag atgctctggg     2160

ccatatcctg ccccagctgg ggaaagactg gacacaccag ggcatcacca gtctctatca     2220

caaaatccaa ctaaatgggt acaagttcct gtactgctcg gcgcgggcca ttggcatggc     2280

ggacctcacc aaggggtacc tgcagtgggt gagcgagggg ggctgtagcc tccccaaggg     2340

ccccatcctt ctgtctccca gcagcctctt ctctgccctc cacagagagg tgatcgagaa     2400

gaaaccagag gtgttcaagg tcgcctgcct gagtgacatc cagcagctgt ttctgcccca     2460

cggacagccc ttctatgctg cctttgggaa taggcccaat gatgtctttg cctaccggca     2520

ggtgggcctg cctgagtcac gcatcttcac agtcaacccc cggggagagc tcatccagga     2580

gctcataaag aaccacaaat ccacgtatga gcggcttggt gaagtggtcg agctcctctt     2640

cccacctgtg gcccgtggcc ccagcacaga cctggccaac cctgaataca gtaacttctg     2700

ctactggcgg gagccactgc ctgctgtgga ccttgatacc ctggactgaa cctgccctgg     2760

ctggctcctc ctccctggcc cggcccagga ctggctaggt gtcctggggt ataggagggt     2820

gggaattgga gtgtcatggg gcaaacccac tgaaggggaa ggaggaggct gcaggttggt     2880

tggcagctag agagactccc ccatcttccc cgtcatattt ttgccagcta agctgcagct     2940

gctccaggcg tcagtgtggc actgtcctgg ggcaattagc ttgtcatctg ggcccttgca     3000

gggttctttt tttttttttt tttttttttt tcctgagaca gggtcttgtt ctgttgccca     3060

ggctggagtg cagtggcatg atctctcggc tcactgcaac ctccgcctcc cgggttcaag     3120

cgattcacct gcctcagcct cccaagtagc tgggattaca ggcgtgtacc accacgcctg     3180

gctaattttc gtgtttttag tagagatggg ttttcaccac attggccagg ctggtctcga     3240

actcctgacc tcaagtgatt tgcccacctc ggcctcccaa agtgctggga ttacaggcat     3300

gagctaccat gccaggcctc cttgcagggt tttctatgcc cttgatatct gtctccctgt     3360

caacctggga ccttgctgta agtcttgata ggacagggag aagagggagg ccctaccgag     3420

gctcgaggct tcagtgaagg gtgacagcag tgggagtgtg gtacagcctc tggaaggaca     3480

cagtgttctc cccgcccctt gtctgggagc caggactgta ccctccgaag ccagacatca     3540

ctgccaacat atcccccttg ctggtgccct ggcatctcag cacatgacac acacccacac     3600

ctgcaggctg tggttccggc ttggcctgct ccccgtccgg ctgctgccgc tgcctctctc     3660

cagacctcgc ttaaggacag tcccaaactc agctggggca ggtgttggcc tgaaagtcct     3720

cccccagcct ctgctggcca gcttggtgct cacagctgct gggtaagctc ttgcctaagg     3780

agctgtggga agcagggctg atgccccagc aacctctcct cccactgtct ttgaagaaag     3840

tagctttaga ccggctaaaa gctttaatcc agagcctgcc ctactctgat agtaccagag     3900

tggagggcag aataccaaat gtccaggaac caaaggcagg gctgtgggga cctgaagagc     3960

agcacagtgg ggcccgtgct gctgtggggg aaactgaggc tgggagcctc agcagagacc     4020

ggtgtcaaga gtctctggga actgcatagg cctgaggaac atgcattttc aagttgtcca     4080

ttgatggttt cgtacctgaa tttctcacct tttgtgaaca tcttgggagg gtgggggttt     4140

tgcaggggtg ttaaaagcaa ggcttggagc ccctttcctc cagctggtgg ctccttctca     4200

gggcctggcc tcattcaggc cactttgtag agaaatgccc tgacctcgca ggaaggattt     4260

ccccaccccc aagtggaagg aagaggacag tgtgggcacc agagggccct ggaaacatct     4320

taggggaagg aaaggaaaag gataaatttg gagtgggggg tctctaaaca gattgcctgg     4380

attccgttct ttcctggggt tctacagctg cctaagccct caccttgggg gaggatcaaa     4440

gggaataaag agaactcttg gctga                                           4465


<210>  40
<211>  852
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Asn Tyr Val Gly Gln Leu Ala Glu Thr Val Phe Gly Thr Val Lys 
1               5                   10                  15      


Glu Leu Tyr Arg Gly Leu Asn Pro Ala Thr Leu Ser Gly Gly Ile Asp 
            20                  25                  30          


Val Leu Val Val Lys Gln Val Asp Gly Ser Phe Arg Cys Ser Pro Phe 
        35                  40                  45              


His Val Arg Phe Gly Lys Leu Gly Val Leu Arg Ser Arg Glu Lys Val 
    50                  55                  60                  


Val Asp Ile Glu Leu Asn Gly Glu Pro Val Asp Leu His Met Lys Leu 
65                  70                  75                  80  


Gly Asp Ser Gly Glu Ala Phe Phe Val Gln Glu Leu Glu Ser Asp Asp 
                85                  90                  95      


Glu His Val Pro Pro Gly Leu Cys Thr Ser Pro Ile Pro Trp Gly Gly 
            100                 105                 110         


Leu Ser Gly Phe Pro Ser Asp Ser Gln Leu Gly Thr Ala Ser Glu Pro 
        115                 120                 125             


Glu Gly Leu Val Met Ala Gly Thr Ala Ser Thr Gly Arg Arg Lys Arg 
    130                 135                 140                 


Arg Arg Arg Arg Lys Pro Lys Gln Lys Glu Asp Ala Val Ala Thr Asp 
145                 150                 155                 160 


Ser Ser Pro Glu Glu Leu Glu Ala Gly Ala Glu Ser Glu Leu Ser Leu 
                165                 170                 175     


Pro Glu Lys Leu Arg Pro Glu Pro Pro Gly Ser Val Gln Leu Glu Glu 
            180                 185                 190         


Lys Ser Ser Leu Gln Pro Lys Asp Ile Tyr Pro Tyr Ser Asp Gly Glu 
        195                 200                 205             


Trp Pro Pro Gln Ala Ser Leu Ser Ala Gly Glu Leu Thr Ser Pro Lys 
    210                 215                 220                 


Ser Asp Ser Glu Leu Glu Val Arg Thr Pro Glu Pro Ser Pro Leu Arg 
225                 230                 235                 240 


Ala Glu Ser His Met Gln Trp Ala Trp Gly Arg Leu Pro Lys Val Ala 
                245                 250                 255     


Arg Ala Glu Arg Pro Glu Ser Ser Val Val Leu Glu Gly Arg Ala Gly 
            260                 265                 270         


Ala Thr Ser Pro Pro Arg Gly Gly Pro Ser Thr Pro Ser Thr Ser Val 
        275                 280                 285             


Ala Gly Gly Val Asp Pro Leu Gly Leu Pro Ile Gln Gln Thr Glu Ala 
    290                 295                 300                 


Gly Ala Asp Leu Gln Pro Asp Thr Glu Asp Pro Thr Leu Val Gly Pro 
305                 310                 315                 320 


Pro Leu His Thr Pro Glu Thr Glu Glu Ser Lys Thr Gln Ser Ser Gly 
                325                 330                 335     


Asp Met Gly Leu Pro Pro Ala Ser Lys Ser Trp Ser Trp Ala Thr Leu 
            340                 345                 350         


Glu Val Pro Val Pro Thr Gly Gln Pro Glu Arg Val Ser Arg Gly Lys 
        355                 360                 365             


Gly Ser Pro Lys Arg Ser Gln His Leu Gly Pro Ser Asp Ile Tyr Leu 
    370                 375                 380                 


Asp Asp Leu Pro Ser Leu Asp Ser Glu Asn Ala Ala Leu Tyr Phe Pro 
385                 390                 395                 400 


Gln Ser Asp Ser Gly Leu Gly Ala Arg Arg Trp Ser Glu Pro Ser Ser 
                405                 410                 415     


Gln Lys Ser Leu Arg Asp Pro Asn Pro Glu His Glu Pro Glu Pro Thr 
            420                 425                 430         


Leu Asp Thr Val Asp Thr Ile Ala Leu Ser Leu Cys Gly Gly Leu Ala 
        435                 440                 445             


Asp Ser Arg Asp Ile Ser Leu Glu Lys Phe Asn Gln His Ser Val Ser 
    450                 455                 460                 


Tyr Gln Asp Leu Thr Lys Asn Pro Gly Leu Leu Asp Asp Pro Asn Leu 
465                 470                 475                 480 


Val Val Lys Ile Asn Gly Lys His Tyr Asn Trp Ala Val Ala Ala Pro 
                485                 490                 495     


Met Ile Leu Ser Leu Gln Ala Phe Gln Lys Asn Leu Pro Lys Ser Thr 
            500                 505                 510         


Met Asp Lys Leu Glu Arg Glu Lys Met Pro Arg Lys Gly Gly Arg Trp 
        515                 520                 525             


Trp Phe Ser Trp Arg Arg Arg Asp Phe Leu Ala Glu Glu Arg Ser Ala 
    530                 535                 540                 


Gln Lys Glu Lys Thr Ala Ala Lys Glu Gln Gln Gly Glu Lys Thr Glu 
545                 550                 555                 560 


Val Leu Ser Ser Asp Asp Asp Ala Pro Asp Ser Pro Val Ile Leu Glu 
                565                 570                 575     


Ile Pro Ser Leu Pro Pro Ser Thr Pro Pro Ser Thr Pro Thr Tyr Lys 
            580                 585                 590         


Lys Ser Leu Arg Leu Ser Ser Asp Gln Ile Arg Arg Leu Asn Leu Gln 
        595                 600                 605             


Glu Gly Ala Asn Asp Val Val Phe Ser Val Thr Thr Gln Tyr Gln Gly 
    610                 615                 620                 


Thr Cys Arg Cys Lys Ala Thr Ile Tyr Leu Trp Lys Trp Asp Asp Lys 
625                 630                 635                 640 


Val Val Ile Ser Asp Ile Asp Gly Thr Ile Thr Lys Ser Asp Ala Leu 
                645                 650                 655     


Gly His Ile Leu Pro Gln Leu Gly Lys Asp Trp Thr His Gln Gly Ile 
            660                 665                 670         


Thr Ser Leu Tyr His Lys Ile Gln Leu Asn Gly Tyr Lys Phe Leu Tyr 
        675                 680                 685             


Cys Ser Ala Arg Ala Ile Gly Met Ala Asp Leu Thr Lys Gly Tyr Leu 
    690                 695                 700                 


Gln Trp Val Ser Glu Gly Gly Cys Ser Leu Pro Lys Gly Pro Ile Leu 
705                 710                 715                 720 


Leu Ser Pro Ser Ser Leu Phe Ser Ala Leu His Arg Glu Val Ile Glu 
                725                 730                 735     


Lys Lys Pro Glu Val Phe Lys Val Ala Cys Leu Ser Asp Ile Gln Gln 
            740                 745                 750         


Leu Phe Leu Pro His Gly Gln Pro Phe Tyr Ala Ala Phe Gly Asn Arg 
        755                 760                 765             


Pro Asn Asp Val Phe Ala Tyr Arg Gln Val Gly Leu Pro Glu Ser Arg 
    770                 775                 780                 


Ile Phe Thr Val Asn Pro Arg Gly Glu Leu Ile Gln Glu Leu Ile Lys 
785                 790                 795                 800 


Asn His Lys Ser Thr Tyr Glu Arg Leu Gly Glu Val Val Glu Leu Leu 
                805                 810                 815     


Phe Pro Pro Val Ala Arg Gly Pro Ser Thr Asp Leu Ala Asn Pro Glu 
            820                 825                 830         


Tyr Ser Asn Phe Cys Tyr Trp Arg Glu Pro Leu Pro Ala Val Asp Leu 
        835                 840                 845             


Asp Thr Leu Asp 
    850         


<210>  41
<211>  6015
<212>  DNA
<213>  Homo sapiens

<400>  41
gctgagctcc agctgtgcca gaggcacccg agccctgaga gtccgccgcc aacgcgcagg       60

tgctagcggc cccttcgccc tgcagcccct ttgcttttac tctgtccaaa gttaacatgt      120

cactgaaaaa cgagccacgg gtaaatacct ctgcactgca gaaaattgct gctgacatga      180

gtaatatcat agaaaatctg gacacgcggg aactccactt tgagggagag gaggtagact      240

acgacgtgtc tcccagcgat cccaagatac aagaagtgta tatccctttc tctgctattt      300

ataacactca aggatttaag gagcctaata tacagacgta tctctccggc tgtccaataa      360

aagcacaagt tctggaagtg gaacgcttca catctacaac aagggtacca agtattaatc      420

tttacactat tgaattaaca catggggaat ttaaatggca agttaagagg aaattcaagc      480

attttcaaga atttcacaga gagctgctca agtacaaagc ctttatccgc atccccattc      540

ccactagaag acacacgttt aggaggcaaa acgtcagaga ggagcctcga gagatgccca      600

gtttgccccg ttcatctgaa aacatgataa gagaagaaca attccttggt agaagaaaac      660

aactggaaga ttacttgaca aagatactaa aaatgcccat gtatagaaac tatcatgcca      720

caacagagtt tcttgatata agccagctgt ctttcatcca tgatttggga ccaaagggca      780

tagaaggtat gataatgaaa agatctggag gacacagaat accaggcttg aattgctgtg      840

gtcagggaag agcctgctac agatggtcaa aaagatggtt aatagtgaaa gattcctttt      900

tattgtatat gaaaccagac agcggtgcca ttgccttcgt cctgctggta gacaaagaat      960

tcaaaattaa ggtggggaag aaggagacag aaacgaaata tggaatccga attgataatc     1020

tttcaaggac acttatttta aaatgcaaca gctatagaca tgctcggtgg tggggagggg     1080

ctatagaaga attcatccag aaacatggca ccaactttct caaagatcat cgatttgggt     1140

catatgctgc tatccaagag aatgctttag ctaaatggta tgttaatgcc aaaggatatt     1200

ttgaagatgt ggcaaatgca atggaagagg caaatgaaga gatttttatc acagactggt     1260

ggctgagtcc agaaatcttc ctgaaacgcc cagtggttga gggaaatcgt tggaggttgg     1320

actgcattct taaacgaaaa gcacaacaag gagtgaggat cttcataatg ctctacaaag     1380

aggtggaact cgctcttggc atcaatagtg aatacaccaa gaggactttg atgcgtctac     1440

atcccaacat aaaggtgatg agacacccgg atcatgtgtc atccaccgtc tatttgtggg     1500

ctcaccatga gaagcttgtc atcattgacc aatcggtggc ctttgtggga gggattgacc     1560

tggcctatgg aaggtgggac gacaatgagc acagactcac agacgtgggc agtgtgaagc     1620

gggtcacttc aggaccgtct ctgggttccc tcccacctgc cgcaatggag tctatggaat     1680

ccttaagact caaagataaa aatgagcctg ttcaaaacct acccatccag aagagtattg     1740

atgatgtgga ttcaaaactg aaaggaatag gaaagccaag aaagttctcc aaatttagtc     1800

tctacaagca gctccacagg caccacctgc acgacgcaga tagcatcagc agcattgaca     1860

gcacctccag ttattttaat cactatagaa gtcatcacaa tttaatccat ggtttaaaac     1920

cccacttcaa actctttcac ccgtccagtg agtctgagca aggactcact agacctcatg     1980

ctgataccgg gtccatccgt agtttacaga caggtgtggg agagctgcat ggggaaacca     2040

gattctggca tggaaaggac tactgcaatt tcgtcttcaa agactgggtt caacttgata     2100

aaccttttgc tgatttcatt gacaggtact ccacgccccg gatgccctgg catgacattg     2160

cctctgcagt ccacgggaag gcggctcgtg atgtggcacg tcacttcatc cagcgctgga     2220

acttcacaaa aattatgaaa tcaaaatatc ggtccctttc ttatcctttt ctgcttccaa     2280

agtctcaaac aacagcccat gagttgagat atcaagtgcc tgggtctgtc catgctaacg     2340

tacagttgct ccgctctgct gctgattggt ctgctggtat aaagtaccat gaagagtcca     2400

tccacgccgc ttacgtccat gtgatagaga acagcaggca ctatatctat atcgaaaacc     2460

agtttttcat aagctgtgct gatgacaaag ttgtgttcaa caagataggc gatgccattg     2520

cccagaggat cctgaaagct cacagggaaa accagaaata ccgggtatat gtcgtgatac     2580

cacttctgcc agggttcgaa ggagacattt caaccggcgg aggaaatgct ctacaggcaa     2640

tcatgcactt caactacaga accatgtgca gaggagaaaa ttccatcctt ggacagttaa     2700

aagcagagct tggtaatcag tggataaatt acatatcatt ctgtggtctt agaacacatg     2760

cagagctcga aggaaaccta gtaactgagc ttatctatgt ccacagcaag ttgttaattg     2820

ctgatgataa cactgttatt attggctctg ccaacataaa tgaccgcagc atgctgggaa     2880

agcgtgacag tgaaatggct gtcattgtgc aagatacaga gactgttcct tcagtaatgg     2940

atggaaaaga gtaccaagct ggccggtttg cccgaggact tcggctacag tgctttaggg     3000

ttgtccttgg ctatcttgat gacccaagtg aggacattca ggatccagtg agtgacaaat     3060

tcttcaagga ggtgtgggtt tcaacagcag ctcgaaatgc tacaatttat gacaaggttt     3120

tccggtgcct tcccaatgat gaagtacaca atttaattca gctgagagac tttataaaca     3180

agcccgtatt agctaaggaa gatcccattc gagctgagga ggaactgaag aagatccgtg     3240

gatttttggt gcaattcccc ttttatttct tgtctgaaga aagcctactg ccttctgttg     3300

ggaccaaaga ggccatagtg cccatggagg tttggactta agagatattc attggcagct     3360

caaagacttc caccctggag accacactgc acacagtgac ttcctgggga tgtcatagcc     3420

aaagccaggc ctgacgcatt ctcgtatcca acccaaggac cttttggaat gactggggag     3480

ggctgcagtc acattgatgt aaggactgta aacatcagca agactttata attccttctg     3540

cctaacttgt aaaaaggggg ctgcattctt gttggtagca tgtactctgt tgagtaaaac     3600

acatattcaa attccgtata ccaaaatcca tttcctttgt aacaagaatt taccagtaac     3660

tgtgatctag gttgccaaaa gttgtctgaa tctccttatt cttctctgat cttcatttat     3720

gcagccaatg tctagctgga cctgccctca tcttgcagtt catacaggca ctgtttgaga     3780

gattgtttat tattagatgt tgtaatgctg cttcaagatt cttcatggtt acatgggatg     3840

cccctgctca tctggtcctg aagtagtaac attcacccaa atgaggatat agtcattatt     3900

ccttttcagt cactgtacga acacggcaga ctttagccta cacagtagac tgtgttaggc     3960

acttctggta acattgacac tgtatcttga caccactaag caacaggaag gaataaattc     4020

caatattgag acagagattt atttcatttt gctcccaaag gcactgacaa catgagtcct     4080

tgtgattagg cccacctgat caaatgtaaa aacatgcatg ggatatttga ttacgtaaca     4140

accagctaaa actgagagca cacagccttc ggaaaccccc aaggtgtcga ggaggatcag     4200

atccagataa gagaagatga ttccttctag tcctgtaaaa tttcctgtca tccttagctg     4260

ctgggttgat tgaaatttga tctctacatt tcaaaatcaa actagtgaat acagtttgtc     4320

tttcaagaga atcagaggca tcgtaactcc taccaagtta gtaagtatga gtctaacctt     4380

gtttgacatt caggtcttct gctacattat cttctttgag aaaaattaat tgattataaa     4440

atatgtgcta cttcacttac attattaaat atgtattaac gcctctcacc agggcttcca     4500

gtgaagttac aatgccctag tctgtgaatt agtctggaaa cgtgtttttc cttttcggat     4560

gttagagtac cctttgataa actaaatttt actaagctga acaactctga cagtctaaag     4620

agctaatgtg ggttaccaaa aggcctgtac ctgtaaaaca aaatgcaggt gtaatgatta     4680

tacatgtcta tggattacct ggacatactc tcatttgggt tgttcttcaa agaagcaagc     4740

agccgatccc tgttttcata aagctaatac ttcagttgga aaaattaaac aggagcacaa     4800

agtcagggat aggggttagc agaagagaga aatagtgtca catcaagggc aggatctcat     4860

agctagggaa catttcacaa ataaggtgag attttgtaac caataataaa aatgaatgtt     4920

tttataagta aataacttat ttttcatatg gctaaagatg gtaaaatgac ttcattctat     4980

agccattgta aataagaatt tgctattgat gaaagaagtt cagattggca tttgaagtat     5040

tgagtgtatg ggatctctaa ggatttctta gattttatat ttaaatattt tttaaacctt     5100

agaggagtca acaaactggc tcttgatttt cagcacccta ctctcatgaa aaaagcctga     5160

aaggaccctt tcccttataa gtaatttaat ccaatttctc cccattttat agatgaggaa     5220

actgaggctc agatcagatg agaactcact taaatccact caatgtgtag atggtagagc     5280

tgggactagc aacattgctg cagcccattg ttggcctctc tcttcacttt atcattgccc     5340

aagaatgagg atatgcagta aacagaattc aggcaagata cctctaagct gttttgaacc     5400

ctctgatatt ttgtatttat gtgtttgtct gtctccccct actagaatgt aagctccatg     5460

gggcagggac ttcactgtat tttgttcata gtgtatcccc agagcctgga ccagtgcttg     5520

gcacatagga gatggcaata aatgcttgta gaattaataa acaaggtgaa ggagagagct     5580

aatgaaatga aaatcttagt ctcatataag aagtcttact actgctttct atggcaagtt     5640

ccttttctat tgcatcttcc caaagacaag atgctcatct gcaaaggggt gataagattt     5700

acttggaggg attttatgga aaattcagtg caataattgc tttttttttt ttttttgcag     5760

tagcagttta catagtacag cattctgcaa aaattgcatg aaatgtggac acaagatgta     5820

ctgtatgact taattacctg tcattctctg acaccattac tacctactag aagttcaaat     5880

aatttatctt taacattgca atatctgata aactttttaa aatgtaaata attcaaagcc     5940

ttgaaaatct atcatgaatc tgctcaacat ttcaaagtga ctattttgaa atgcctataa     6000

atgctatata cctga                                                      6015


<210>  42
<211>  1074
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Leu Lys Asn Glu Pro Arg Val Asn Thr Ser Ala Leu Gln Lys 
1               5                   10                  15      


Ile Ala Ala Asp Met Ser Asn Ile Ile Glu Asn Leu Asp Thr Arg Glu 
            20                  25                  30          


Leu His Phe Glu Gly Glu Glu Val Asp Tyr Asp Val Ser Pro Ser Asp 
        35                  40                  45              


Pro Lys Ile Gln Glu Val Tyr Ile Pro Phe Ser Ala Ile Tyr Asn Thr 
    50                  55                  60                  


Gln Gly Phe Lys Glu Pro Asn Ile Gln Thr Tyr Leu Ser Gly Cys Pro 
65                  70                  75                  80  


Ile Lys Ala Gln Val Leu Glu Val Glu Arg Phe Thr Ser Thr Thr Arg 
                85                  90                  95      


Val Pro Ser Ile Asn Leu Tyr Thr Ile Glu Leu Thr His Gly Glu Phe 
            100                 105                 110         


Lys Trp Gln Val Lys Arg Lys Phe Lys His Phe Gln Glu Phe His Arg 
        115                 120                 125             


Glu Leu Leu Lys Tyr Lys Ala Phe Ile Arg Ile Pro Ile Pro Thr Arg 
    130                 135                 140                 


Arg His Thr Phe Arg Arg Gln Asn Val Arg Glu Glu Pro Arg Glu Met 
145                 150                 155                 160 


Pro Ser Leu Pro Arg Ser Ser Glu Asn Met Ile Arg Glu Glu Gln Phe 
                165                 170                 175     


Leu Gly Arg Arg Lys Gln Leu Glu Asp Tyr Leu Thr Lys Ile Leu Lys 
            180                 185                 190         


Met Pro Met Tyr Arg Asn Tyr His Ala Thr Thr Glu Phe Leu Asp Ile 
        195                 200                 205             


Ser Gln Leu Ser Phe Ile His Asp Leu Gly Pro Lys Gly Ile Glu Gly 
    210                 215                 220                 


Met Ile Met Lys Arg Ser Gly Gly His Arg Ile Pro Gly Leu Asn Cys 
225                 230                 235                 240 


Cys Gly Gln Gly Arg Ala Cys Tyr Arg Trp Ser Lys Arg Trp Leu Ile 
                245                 250                 255     


Val Lys Asp Ser Phe Leu Leu Tyr Met Lys Pro Asp Ser Gly Ala Ile 
            260                 265                 270         


Ala Phe Val Leu Leu Val Asp Lys Glu Phe Lys Ile Lys Val Gly Lys 
        275                 280                 285             


Lys Glu Thr Glu Thr Lys Tyr Gly Ile Arg Ile Asp Asn Leu Ser Arg 
    290                 295                 300                 


Thr Leu Ile Leu Lys Cys Asn Ser Tyr Arg His Ala Arg Trp Trp Gly 
305                 310                 315                 320 


Gly Ala Ile Glu Glu Phe Ile Gln Lys His Gly Thr Asn Phe Leu Lys 
                325                 330                 335     


Asp His Arg Phe Gly Ser Tyr Ala Ala Ile Gln Glu Asn Ala Leu Ala 
            340                 345                 350         


Lys Trp Tyr Val Asn Ala Lys Gly Tyr Phe Glu Asp Val Ala Asn Ala 
        355                 360                 365             


Met Glu Glu Ala Asn Glu Glu Ile Phe Ile Thr Asp Trp Trp Leu Ser 
    370                 375                 380                 


Pro Glu Ile Phe Leu Lys Arg Pro Val Val Glu Gly Asn Arg Trp Arg 
385                 390                 395                 400 


Leu Asp Cys Ile Leu Lys Arg Lys Ala Gln Gln Gly Val Arg Ile Phe 
                405                 410                 415     


Ile Met Leu Tyr Lys Glu Val Glu Leu Ala Leu Gly Ile Asn Ser Glu 
            420                 425                 430         


Tyr Thr Lys Arg Thr Leu Met Arg Leu His Pro Asn Ile Lys Val Met 
        435                 440                 445             


Arg His Pro Asp His Val Ser Ser Thr Val Tyr Leu Trp Ala His His 
    450                 455                 460                 


Glu Lys Leu Val Ile Ile Asp Gln Ser Val Ala Phe Val Gly Gly Ile 
465                 470                 475                 480 


Asp Leu Ala Tyr Gly Arg Trp Asp Asp Asn Glu His Arg Leu Thr Asp 
                485                 490                 495     


Val Gly Ser Val Lys Arg Val Thr Ser Gly Pro Ser Leu Gly Ser Leu 
            500                 505                 510         


Pro Pro Ala Ala Met Glu Ser Met Glu Ser Leu Arg Leu Lys Asp Lys 
        515                 520                 525             


Asn Glu Pro Val Gln Asn Leu Pro Ile Gln Lys Ser Ile Asp Asp Val 
    530                 535                 540                 


Asp Ser Lys Leu Lys Gly Ile Gly Lys Pro Arg Lys Phe Ser Lys Phe 
545                 550                 555                 560 


Ser Leu Tyr Lys Gln Leu His Arg His His Leu His Asp Ala Asp Ser 
                565                 570                 575     


Ile Ser Ser Ile Asp Ser Thr Ser Ser Tyr Phe Asn His Tyr Arg Ser 
            580                 585                 590         


His His Asn Leu Ile His Gly Leu Lys Pro His Phe Lys Leu Phe His 
        595                 600                 605             


Pro Ser Ser Glu Ser Glu Gln Gly Leu Thr Arg Pro His Ala Asp Thr 
    610                 615                 620                 


Gly Ser Ile Arg Ser Leu Gln Thr Gly Val Gly Glu Leu His Gly Glu 
625                 630                 635                 640 


Thr Arg Phe Trp His Gly Lys Asp Tyr Cys Asn Phe Val Phe Lys Asp 
                645                 650                 655     


Trp Val Gln Leu Asp Lys Pro Phe Ala Asp Phe Ile Asp Arg Tyr Ser 
            660                 665                 670         


Thr Pro Arg Met Pro Trp His Asp Ile Ala Ser Ala Val His Gly Lys 
        675                 680                 685             


Ala Ala Arg Asp Val Ala Arg His Phe Ile Gln Arg Trp Asn Phe Thr 
    690                 695                 700                 


Lys Ile Met Lys Ser Lys Tyr Arg Ser Leu Ser Tyr Pro Phe Leu Leu 
705                 710                 715                 720 


Pro Lys Ser Gln Thr Thr Ala His Glu Leu Arg Tyr Gln Val Pro Gly 
                725                 730                 735     


Ser Val His Ala Asn Val Gln Leu Leu Arg Ser Ala Ala Asp Trp Ser 
            740                 745                 750         


Ala Gly Ile Lys Tyr His Glu Glu Ser Ile His Ala Ala Tyr Val His 
        755                 760                 765             


Val Ile Glu Asn Ser Arg His Tyr Ile Tyr Ile Glu Asn Gln Phe Phe 
    770                 775                 780                 


Ile Ser Cys Ala Asp Asp Lys Val Val Phe Asn Lys Ile Gly Asp Ala 
785                 790                 795                 800 


Ile Ala Gln Arg Ile Leu Lys Ala His Arg Glu Asn Gln Lys Tyr Arg 
                805                 810                 815     


Val Tyr Val Val Ile Pro Leu Leu Pro Gly Phe Glu Gly Asp Ile Ser 
            820                 825                 830         


Thr Gly Gly Gly Asn Ala Leu Gln Ala Ile Met His Phe Asn Tyr Arg 
        835                 840                 845             


Thr Met Cys Arg Gly Glu Asn Ser Ile Leu Gly Gln Leu Lys Ala Glu 
    850                 855                 860                 


Leu Gly Asn Gln Trp Ile Asn Tyr Ile Ser Phe Cys Gly Leu Arg Thr 
865                 870                 875                 880 


His Ala Glu Leu Glu Gly Asn Leu Val Thr Glu Leu Ile Tyr Val His 
                885                 890                 895     


Ser Lys Leu Leu Ile Ala Asp Asp Asn Thr Val Ile Ile Gly Ser Ala 
            900                 905                 910         


Asn Ile Asn Asp Arg Ser Met Leu Gly Lys Arg Asp Ser Glu Met Ala 
        915                 920                 925             


Val Ile Val Gln Asp Thr Glu Thr Val Pro Ser Val Met Asp Gly Lys 
    930                 935                 940                 


Glu Tyr Gln Ala Gly Arg Phe Ala Arg Gly Leu Arg Leu Gln Cys Phe 
945                 950                 955                 960 


Arg Val Val Leu Gly Tyr Leu Asp Asp Pro Ser Glu Asp Ile Gln Asp 
                965                 970                 975     


Pro Val Ser Asp Lys Phe Phe Lys Glu Val Trp Val Ser Thr Ala Ala 
            980                 985                 990         


Arg Asn Ala Thr Ile Tyr Asp Lys  Val Phe Arg Cys Leu  Pro Asn Asp 
        995                 1000                 1005             


Glu Val  His Asn Leu Ile Gln  Leu Arg Asp Phe Ile  Asn Lys Pro 
    1010                 1015                 1020             


Val Leu  Ala Lys Glu Asp Pro  Ile Arg Ala Glu Glu  Glu Leu Lys 
    1025                 1030                 1035             


Lys Ile  Arg Gly Phe Leu Val  Gln Phe Pro Phe Tyr  Phe Leu Ser 
    1040                 1045                 1050             


Glu Glu  Ser Leu Leu Pro Ser  Val Gly Thr Lys Glu  Ala Ile Val 
    1055                 1060                 1065             


Pro Met  Glu Val Trp Thr 
    1070                 


<210>  43
<211>  3410
<212>  DNA
<213>  Homo sapiens

<400>  43
gtgggctccg gctgcagctc cggtctgctc tcttggctcc ggaacccccg cgggcgctgg       60

ctccgtctgc cagggatgac ggcgacccct gagagcctct tccccactgg ggacgaactg      120

gactccagcc agctccagat ggagtccgat gaggtggaca ccctgaagga gggagaggac      180

ccagccgacc ggatgcaccc gtttctggcc atctatgagc ttcagtctct gaaagtgcac      240

cccttggtgt tcgcacctgg ggtccctgtc acagcccagg tggtgggcac cgaaagatat      300

accagcggat ccaaggtggg aacctgcact ctgtattctg tccgcttgac tcacggcgac      360

ttttcctgga caaccaagaa gaaataccgt cattttcagg agctgcatcg ggacctcctg      420

agacacaaag tcttgatgag tctgctccct ctggctcgat ttgccgttgc ctattctcca      480

gcccgagatg caggcaacag agagatgccc tctctacccc gggcaggtcc tgagggctcc      540

accagacatg cagccagcaa acagaaatac ctggagaatt acctcaaccg tctcttgacc      600

atgtctttct atcgcaacta ccatgccatg acagagttcc tggaagtcag tcagctgtcc      660

tttatcccgg acttgggccg caaaggactg gaggggatga tccggaagcg ctcaggtggc      720

caccgtgttc ctggcctcac ctgctgtggc cgagaccaag tttgttatcg ctggtccaag      780

aggtggctgg tggtgaagga ctccttcctg ctgtacatgt gcctcgagac aggtgccatc      840

tcatttgttc agctctttga ccctggcttt gaggtgcaag tggggaaaag gagcacggag      900

gcacggcacg gcgtgcggat cgatacctcc cacaggtcct tgattctcaa gtgcagcagc      960

taccggcagg cacggtggtg ggcccaagag atcactgagc tggcacaggg cccaggcaga     1020

gacttcctac agctgcaccg gcatgacagc tacgccccac cccggcctgg gaccttggcc     1080

cggtggtttg tgaatggggc aggttacttt gctgctgtgg cagatgccat ccttcgagct     1140

caagaggaga ttttcatcac agactggtgg ttgagtcctg aggtttacct gaagcgtccg     1200

gcccattcag atgactggag actggacatt atgctcaaga ggaaggcgga ggagggtgtc     1260

cgtgtgtcta ttctgctgtt taaagaagtg gaattggcct tgggcatcaa cagtggctat     1320

agcaagaggg cgctgatgct gctgcacccc aacataaagg tgatgcgtca cccagaccaa     1380

gtgacgttgt gggcccatca tgagaagctc ctggtggtgg accaagtggt agcattcctg     1440

gggggactgg accttgccta tggccgctgg gatgacctgc actaccgact gactgacctt     1500

ggagactcct ctgaatcagc tgcctcccag cctcccaccc cgcgcccaga ctcaccagcc     1560

accccagacc tctctcacaa ccaattcttc tggctgggca aggactacag caatcttatc     1620

accaaggact gggtgcagct ggaccggcct ttcgaagatt tcattgacag ggagacgacc     1680

cctcggatgc catggcggga cgttggggtg gtcgtccatg gcctaccggc ccgggacctt     1740

gcccggcact tcatccagcg ctggaacttc accaagacca ccaaggccaa gtacaagact     1800

cccacatacc cctacctgct tcccaagtct accagcacgg ccaatcagct ccccttcaca     1860

cttccaggag ggcagtgcac caccgtacag gtcttgcgat cagtggaccg ctggtcagca     1920

gggactctgg agaactccat cctcaatgcc tacctgcaca ccatcaggga gagccagcac     1980

ttcctctaca ttgagaatca gttcttcatt agctgctcag atgggcggac ggttctgaac     2040

aaggtgggcg atgagattgt ggacagaatc ctgaaggccc acaaacaggg gtggtgttac     2100

cgagtctacg tgcttttgcc cttactccct ggcttcgagg gtgacatctc cacgggcggt     2160

ggcaactcca tccaggccat tctgcacttt acttacagga ccctgtgtcg tggggagtat     2220

tcaatcctgc atcgccttaa agcagccatg gggacagcat ggcgggacta tatttccatc     2280

tgcgggcttc gtacacacgg agagctgggc gggcaccccg tctcggagct catctacatc     2340

cacagcaagg tgctcatcgc agatgaccgg acagtcatca ttggttctgc aaacatcaat     2400

gaccggagct tgctggggaa gcgggacagt gagctggccg tgctgatcga ggacacagag     2460

acggaaccat ccctcatgaa tggggcagag tatcaggcgg gcagtgtgat tcttggagca     2520

aatacccggc cagacttgga tctccgagac cccatctgtg atgacttctt ccagttgtgg     2580

caagacatgg ctgagagcaa cgccaatatc tatgagcaga tcttccgctg cctgccatcc     2640

aatgccacgc gttccctgcg gactctccgg gagtacgtgg ccgtggagcc cttggccacg     2700

gtcagtcccc ccttggctcg gtctgagctc acccaggtcc agggccacct ggtccacttc     2760

cccctcaagt tcctagagga tgagtctttg ctgcccccgc tgggtagcaa ggagggcatg     2820

atccccctag aagtgtggac atagttgagg cccccgtcag ggagaggtca ccagctgctg     2880

tgccccacca cgtctggctc cctgcccctt aaccccaagg actgagggca gtgccctttg     2940

agatctgggg aggcaggcat tcctgaaggg aactagaggt gttacagagg acccttacgt     3000

gagaaatagc tgaaaagggc actcccaacc ctgggctggg gaggaggaga gagtcccaga     3060

gctcatcccc cctgctgccc agtgcaaacc acttctccat gctgcaaagg agaagcacag     3120

ctcctgccag ggtgagcagg gtcaagcctc ttattccagg agaagggggc tctgccccag     3180

gccctactac ccattgttcc cttcctcttc ctgcccttga accccctccc tgtcccaggg     3240

ccctcccagc ccattgctgc caaggtggag ggaaggataa agccacttct ggcttcagcc     3300

cccaccaggg gaaggaagga gggcacatta actccctcca ccagcctgct gacagacact     3360

aactttgtat ccgttcaata agcatttcat aaataaaggt gtagaaaagg                3410


<210>  44
<211>  922
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Thr Ala Thr Pro Glu Ser Leu Phe Pro Thr Gly Asp Glu Leu Asp 
1               5                   10                  15      


Ser Ser Gln Leu Gln Met Glu Ser Asp Glu Val Asp Thr Leu Lys Glu 
            20                  25                  30          


Gly Glu Asp Pro Ala Asp Arg Met His Pro Phe Leu Ala Ile Tyr Glu 
        35                  40                  45              


Leu Gln Ser Leu Lys Val His Pro Leu Val Phe Ala Pro Gly Val Pro 
    50                  55                  60                  


Val Thr Ala Gln Val Val Gly Thr Glu Arg Tyr Thr Ser Gly Ser Lys 
65                  70                  75                  80  


Val Gly Thr Cys Thr Leu Tyr Ser Val Arg Leu Thr His Gly Asp Phe 
                85                  90                  95      


Ser Trp Thr Thr Lys Lys Lys Tyr Arg His Phe Gln Glu Leu His Arg 
            100                 105                 110         


Asp Leu Leu Arg His Lys Val Leu Met Ser Leu Leu Pro Leu Ala Arg 
        115                 120                 125             


Phe Ala Val Ala Tyr Ser Pro Ala Arg Asp Ala Gly Asn Arg Glu Met 
    130                 135                 140                 


Pro Ser Leu Pro Arg Ala Gly Pro Glu Gly Ser Thr Arg His Ala Ala 
145                 150                 155                 160 


Ser Lys Gln Lys Tyr Leu Glu Asn Tyr Leu Asn Arg Leu Leu Thr Met 
                165                 170                 175     


Ser Phe Tyr Arg Asn Tyr His Ala Met Thr Glu Phe Leu Glu Val Ser 
            180                 185                 190         


Gln Leu Ser Phe Ile Pro Asp Leu Gly Arg Lys Gly Leu Glu Gly Met 
        195                 200                 205             


Ile Arg Lys Arg Ser Gly Gly His Arg Val Pro Gly Leu Thr Cys Cys 
    210                 215                 220                 


Gly Arg Asp Gln Val Cys Tyr Arg Trp Ser Lys Arg Trp Leu Val Val 
225                 230                 235                 240 


Lys Asp Ser Phe Leu Leu Tyr Met Cys Leu Glu Thr Gly Ala Ile Ser 
                245                 250                 255     


Phe Val Gln Leu Phe Asp Pro Gly Phe Glu Val Gln Val Gly Lys Arg 
            260                 265                 270         


Ser Thr Glu Ala Arg His Gly Val Arg Ile Asp Thr Ser His Arg Ser 
        275                 280                 285             


Leu Ile Leu Lys Cys Ser Ser Tyr Arg Gln Ala Arg Trp Trp Ala Gln 
    290                 295                 300                 


Glu Ile Thr Glu Leu Ala Gln Gly Pro Gly Arg Asp Phe Leu Gln Leu 
305                 310                 315                 320 


His Arg His Asp Ser Tyr Ala Pro Pro Arg Pro Gly Thr Leu Ala Arg 
                325                 330                 335     


Trp Phe Val Asn Gly Ala Gly Tyr Phe Ala Ala Val Ala Asp Ala Ile 
            340                 345                 350         


Leu Arg Ala Gln Glu Glu Ile Phe Ile Thr Asp Trp Trp Leu Ser Pro 
        355                 360                 365             


Glu Val Tyr Leu Lys Arg Pro Ala His Ser Asp Asp Trp Arg Leu Asp 
    370                 375                 380                 


Ile Met Leu Lys Arg Lys Ala Glu Glu Gly Val Arg Val Ser Ile Leu 
385                 390                 395                 400 


Leu Phe Lys Glu Val Glu Leu Ala Leu Gly Ile Asn Ser Gly Tyr Ser 
                405                 410                 415     


Lys Arg Ala Leu Met Leu Leu His Pro Asn Ile Lys Val Met Arg His 
            420                 425                 430         


Pro Asp Gln Val Thr Leu Trp Ala His His Glu Lys Leu Leu Val Val 
        435                 440                 445             


Asp Gln Val Val Ala Phe Leu Gly Gly Leu Asp Leu Ala Tyr Gly Arg 
    450                 455                 460                 


Trp Asp Asp Leu His Tyr Arg Leu Thr Asp Leu Gly Asp Ser Ser Glu 
465                 470                 475                 480 


Ser Ala Ala Ser Gln Pro Pro Thr Pro Arg Pro Asp Ser Pro Ala Thr 
                485                 490                 495     


Pro Asp Leu Ser His Asn Gln Phe Phe Trp Leu Gly Lys Asp Tyr Ser 
            500                 505                 510         


Asn Leu Ile Thr Lys Asp Trp Val Gln Leu Asp Arg Pro Phe Glu Asp 
        515                 520                 525             


Phe Ile Asp Arg Glu Thr Thr Pro Arg Met Pro Trp Arg Asp Val Gly 
    530                 535                 540                 


Val Val Val His Gly Leu Pro Ala Arg Asp Leu Ala Arg His Phe Ile 
545                 550                 555                 560 


Gln Arg Trp Asn Phe Thr Lys Thr Thr Lys Ala Lys Tyr Lys Thr Pro 
                565                 570                 575     


Thr Tyr Pro Tyr Leu Leu Pro Lys Ser Thr Ser Thr Ala Asn Gln Leu 
            580                 585                 590         


Pro Phe Thr Leu Pro Gly Gly Gln Cys Thr Thr Val Gln Val Leu Arg 
        595                 600                 605             


Ser Val Asp Arg Trp Ser Ala Gly Thr Leu Glu Asn Ser Ile Leu Asn 
    610                 615                 620                 


Ala Tyr Leu His Thr Ile Arg Glu Ser Gln His Phe Leu Tyr Ile Glu 
625                 630                 635                 640 


Asn Gln Phe Phe Ile Ser Cys Ser Asp Gly Arg Thr Val Leu Asn Lys 
                645                 650                 655     


Val Gly Asp Glu Ile Val Asp Arg Ile Leu Lys Ala His Lys Gln Gly 
            660                 665                 670         


Trp Cys Tyr Arg Val Tyr Val Leu Leu Pro Leu Leu Pro Gly Phe Glu 
        675                 680                 685             


Gly Asp Ile Ser Thr Gly Gly Gly Asn Ser Ile Gln Ala Ile Leu His 
    690                 695                 700                 


Phe Thr Tyr Arg Thr Leu Cys Arg Gly Glu Tyr Ser Ile Leu His Arg 
705                 710                 715                 720 


Leu Lys Ala Ala Met Gly Thr Ala Trp Arg Asp Tyr Ile Ser Ile Cys 
                725                 730                 735     


Gly Leu Arg Thr His Gly Glu Leu Gly Gly His Pro Val Ser Glu Leu 
            740                 745                 750         


Ile Tyr Ile His Ser Lys Val Leu Ile Ala Asp Asp Arg Thr Val Ile 
        755                 760                 765             


Ile Gly Ser Ala Asn Ile Asn Asp Arg Ser Leu Leu Gly Lys Arg Asp 
    770                 775                 780                 


Ser Glu Leu Ala Val Leu Ile Glu Asp Thr Glu Thr Glu Pro Ser Leu 
785                 790                 795                 800 


Met Asn Gly Ala Glu Tyr Gln Ala Gly Ser Val Ile Leu Gly Ala Asn 
                805                 810                 815     


Thr Arg Pro Asp Leu Asp Leu Arg Asp Pro Ile Cys Asp Asp Phe Phe 
            820                 825                 830         


Gln Leu Trp Gln Asp Met Ala Glu Ser Asn Ala Asn Ile Tyr Glu Gln 
        835                 840                 845             


Ile Phe Arg Cys Leu Pro Ser Asn Ala Thr Arg Ser Leu Arg Thr Leu 
    850                 855                 860                 


Arg Glu Tyr Val Ala Val Glu Pro Leu Ala Thr Val Ser Pro Pro Leu 
865                 870                 875                 880 


Ala Arg Ser Glu Leu Thr Gln Val Gln Gly His Leu Val His Phe Pro 
                885                 890                 895     


Leu Lys Phe Leu Glu Asp Glu Ser Leu Leu Pro Pro Leu Gly Ser Lys 
            900                 905                 910         


Glu Gly Met Ile Pro Leu Glu Val Trp Thr 
        915                 920         


<210>  45
<211>  1913
<212>  DNA
<213>  Homo sapiens

<400>  45
gggccgtcag gcggggatac agcctggaag gtaatgcatg tccatggtac acaaattcac       60

aagtttggag accctgacac acccaccttc tcacctgggc tctgcgtatc ccccagcctt      120

gagggaagat gaagcctaaa ctgatgtacc aggagctgaa ggtgcctgca gaggagcccg      180

ccaatgagct gcccatgaat gagattgagg cgtggaaggc tgcggaaaag aaagcccgct      240

gggtcctgct ggtcctcatt ctggcggttg tgggcttcgg agccctgatg actcagctgt      300

ttctatggga atacggcgac ttgcatctct ttgggcccaa ccagcgccca gccccctgct      360

atgacccttg cgaagcagtg ctggtggaaa gcattcctga gggcctggac ttccccaatg      420

cctccacggg gaacccttcc accagccagg cctggctggg cctgctcgcc ggtgcgcaca      480

gcagcctgga catcgcctcc ttctactgga ccctcaccaa caatgacacc cacacgcagg      540

agccctctgc ccagcagggt gaggaggtcc tccggcagct gcagaccctg gcaccaaagg      600

gcgtgaacgt ccgcatcgct gtgagcaagc ccagcgggcc ccagccacag gcggacctgc      660

aggctctgct gcagagcggt gcccaggtcc gcatggtgga catgcagaag ctgacccatg      720

gcgtcctgca taccaagttc tgggtggtgg accagaccca cttctacctg ggcagtgcca      780

acatggactg gcgttcactg acccaggtca aggagctggg cgtggtcatg tacaactgca      840

gctgcctggc tcgagacctg accaagatct ttgaggccta ctggttcctg ggccaggcag      900

gcagctccat cccatcaact tggccccggt tctatgacac ccgctacaac caagagacac      960

caatggagat ctgcctcaat ggaacccctg ctctggccta cctggcgagt gcgcccccac     1020

ccctgtgtcc aagtggccgc actccagacc tgaaggctct actcaacgtg gtggacaatg     1080

cccggagttt catctacgtc gctgtcatga actacctgcc cactctggag ttctcccacc     1140

ctcacaggtt ctggcctgcc attgacgatg ggctgcggcg ggccacctac gagcgtggcg     1200

tcaaggtgcg cctgctcatc agctgctggg gacactcgga gccatccatg cgggccttcc     1260

tgctctctct ggctgccctg cgtgacaacc atacccactc tgacatccag gtgaaactct     1320

ttgtggtccc cgcggatgag gcccaggctc gaatcccata tgcccgtgtc aaccacaaca     1380

agtacatggt gactgaacgc gccacctaca tcggaacctc caactggtct ggcaactact     1440

tcacggagac ggcgggcacc tcgctgctgg tgacgcagaa tgggaggggc ggcctgcgga     1500

gccagctgga ggccattttc ctgagggact gggactcccc ttacagccat gaccttgaca     1560

cctcagctga cagcgtgggc aacgcctgcc gcctgctctg aggcccgatc cagtgggcag     1620

gccaaggcct gctgggcccc cgcggaccca ggtgctctgg gtcacggtcc ctgtccccgc     1680

gcccccgctt ctgtctgccc cattgtggct cctcaggctc tctcccctgc tctcccacct     1740

ctacctccac ccccaccggc ctgacgctgt ggccccggga cccagcagag ctgggggagg     1800

gatcagcccc caaagaaatg ggggtgcatg ctgggcctgg ccccctggcc cacccccact     1860

ttccagggca aaaagggccc agggttataa taagtaaata acttgtctgt aca            1913


<210>  46
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Lys Pro Lys Leu Met Tyr Gln Glu Leu Lys Val Pro Ala Glu Glu 
1               5                   10                  15      


Pro Ala Asn Glu Leu Pro Met Asn Glu Ile Glu Ala Trp Lys Ala Ala 
            20                  25                  30          


Glu Lys Lys Ala Arg Trp Val Leu Leu Val Leu Ile Leu Ala Val Val 
        35                  40                  45              


Gly Phe Gly Ala Leu Met Thr Gln Leu Phe Leu Trp Glu Tyr Gly Asp 
    50                  55                  60                  


Leu His Leu Phe Gly Pro Asn Gln Arg Pro Ala Pro Cys Tyr Asp Pro 
65                  70                  75                  80  


Cys Glu Ala Val Leu Val Glu Ser Ile Pro Glu Gly Leu Asp Phe Pro 
                85                  90                  95      


Asn Ala Ser Thr Gly Asn Pro Ser Thr Ser Gln Ala Trp Leu Gly Leu 
            100                 105                 110         


Leu Ala Gly Ala His Ser Ser Leu Asp Ile Ala Ser Phe Tyr Trp Thr 
        115                 120                 125             


Leu Thr Asn Asn Asp Thr His Thr Gln Glu Pro Ser Ala Gln Gln Gly 
    130                 135                 140                 


Glu Glu Val Leu Arg Gln Leu Gln Thr Leu Ala Pro Lys Gly Val Asn 
145                 150                 155                 160 


Val Arg Ile Ala Val Ser Lys Pro Ser Gly Pro Gln Pro Gln Ala Asp 
                165                 170                 175     


Leu Gln Ala Leu Leu Gln Ser Gly Ala Gln Val Arg Met Val Asp Met 
            180                 185                 190         


Gln Lys Leu Thr His Gly Val Leu His Thr Lys Phe Trp Val Val Asp 
        195                 200                 205             


Gln Thr His Phe Tyr Leu Gly Ser Ala Asn Met Asp Trp Arg Ser Leu 
    210                 215                 220                 


Thr Gln Val Lys Glu Leu Gly Val Val Met Tyr Asn Cys Ser Cys Leu 
225                 230                 235                 240 


Ala Arg Asp Leu Thr Lys Ile Phe Glu Ala Tyr Trp Phe Leu Gly Gln 
                245                 250                 255     


Ala Gly Ser Ser Ile Pro Ser Thr Trp Pro Arg Phe Tyr Asp Thr Arg 
            260                 265                 270         


Tyr Asn Gln Glu Thr Pro Met Glu Ile Cys Leu Asn Gly Thr Pro Ala 
        275                 280                 285             


Leu Ala Tyr Leu Ala Ser Ala Pro Pro Pro Leu Cys Pro Ser Gly Arg 
    290                 295                 300                 


Thr Pro Asp Leu Lys Ala Leu Leu Asn Val Val Asp Asn Ala Arg Ser 
305                 310                 315                 320 


Phe Ile Tyr Val Ala Val Met Asn Tyr Leu Pro Thr Leu Glu Phe Ser 
                325                 330                 335     


His Pro His Arg Phe Trp Pro Ala Ile Asp Asp Gly Leu Arg Arg Ala 
            340                 345                 350         


Thr Tyr Glu Arg Gly Val Lys Val Arg Leu Leu Ile Ser Cys Trp Gly 
        355                 360                 365             


His Ser Glu Pro Ser Met Arg Ala Phe Leu Leu Ser Leu Ala Ala Leu 
    370                 375                 380                 


Arg Asp Asn His Thr His Ser Asp Ile Gln Val Lys Leu Phe Val Val 
385                 390                 395                 400 


Pro Ala Asp Glu Ala Gln Ala Arg Ile Pro Tyr Ala Arg Val Asn His 
                405                 410                 415     


Asn Lys Tyr Met Val Thr Glu Arg Ala Thr Tyr Ile Gly Thr Ser Asn 
            420                 425                 430         


Trp Ser Gly Asn Tyr Phe Thr Glu Thr Ala Gly Thr Ser Leu Leu Val 
        435                 440                 445             


Thr Gln Asn Gly Arg Gly Gly Leu Arg Ser Gln Leu Glu Ala Ile Phe 
    450                 455                 460                 


Leu Arg Asp Trp Asp Ser Pro Tyr Ser His Asp Leu Asp Thr Ser Ala 
465                 470                 475                 480 


Asp Ser Val Gly Asn Ala Cys Arg Leu Leu 
                485                 490 


<210>  47
<211>  6492
<212>  DNA
<213>  Homo sapiens

<400>  47
agagaagagg aggttggtgt ggagcacagg cagcaccgag cctgccccgt gagctgaggg       60

cctgcagtct gcggctggaa tcaggataga caccaaggca ggacccccag agagctggag      120

ctgctggtga tgccaggctg ccctgtgcag atgctgaagc ctctttggaa agcagcagtg      180

gcccccacat ggccatgctc catgccgccc cgccgcccgt gggacagaga ggctggcacg      240

ttgcaggtcc tgggagcgct ggctgtgctg tggctgggct ccgtggctct tatctgcctc      300

ctgtggcaag tgccccgtcc tcccacctgg ggccaggtgc agcccaagga cgtgcccagg      360

tcctgggagc atggctccag cccagcttgg gagcccctgg aagcagaggc caggcagcag      420

agggactcct gccagcttgt ccttgtggaa agcatccccc aggacctgcc atctgcagcc      480

ggcagcccct ctgcccagcc tctgggccag gcctggctgc agctgctgga cactgcccag      540

gagagcgtcc acgtggcttc atactactgg tccctcacag ggcctgacat cggggtcaac      600

gactcgtctt cccagctggg agaggctctt ctgcagaagc tgcagcagct gctgggcagg      660

aacatttccc tggctgtggc caccagcagc ccgacactgg ccaggacatc caccgacctg      720

caggttctgg ctgcccgagg tgcccatgta cgacaggtgc ccatggggcg gctcaccagg      780

ggtgttttgc actccaaatt ctgggttgtg gatggacggc acatatacat gggcagtgcc      840

aacatggact ggcggtctct gacgcaggtg aaggagcttg gcgctgtcat ctataactgc      900

agccacctgg cccaagacct ggagaagacc ttccagacct actgggtact gggggtgccc      960

aaggctgtcc tccccaaaac ctggcctcag aacttctcat ctcacttcaa ccgtttccag     1020

cccttccacg gcctctttga tggggtgccc accactgcct acttctcagc gtcgccacca     1080

gcactctgtc cccagggccg cacccgggac ctggaggcgc tgctggcggt gatggggagc     1140

gcccaggagt tcatctatgc ctccgtgatg gagtatttcc ccaccacgcg cttcagccac     1200

cccccgaggt actggccggt gctggacaac gcgctgcggg cggcagcctt cggcaagggc     1260

gtgcgcgtgc gcctgctggt cggctgcgga ctcaacacgg accccaccat gttcccctac     1320

ctgcggtccc tgcaggcgct cagcaacccc gcggccaacg tctctgtgga cgtgaaagtc     1380

ttcatcgtgc cggtggggaa ccattccaac atcccattca gcagggtgaa ccacagcaag     1440

ttcatggtca cggagaaggc agcctacata ggcacctcca actggtcgga ggattacttc     1500

agcagcacgg cgggggtggg cttggtggtc acccagagcc ctggcgcgca gcccgcgggg     1560

gccacggtgc aggagcagct gcggcagctc tttgagcggg actggagttc gcgctacgcc     1620

gtcggcctgg acggacaggc tccgggccag gactgcgttt ggcagggctg aggggggcct     1680

ctttttctct cggcgacccc gccccgcacg cgccctcccc tctgaccccg gcctgggctt     1740

cagccgcttc ctcccgcaag cagcccgggt ccgcactgcg ccaggagccg cctgcgaccg     1800

cccgggcgtc gcaaaccgcc cgcctgctct ctgatttccg agtccagccc cccctgagcc     1860

ccacctcctc cagggagccc tccaggaagc cccttccctg actcctggcc cacaggccag     1920

gcctaaaaaa aactcgtggc ttcccggtgc ctctgtgtga gtcccgcgcg ggcggccctt     1980

catcctcttg ccaagggccc gcctctatgc gcccgcccct gcgaaactgc gccgcgcgac     2040

cgccgtggca gcgcctcagc tagccccggg tccgcgagaa cctggggcgg ggcggggcgg     2100

ggaccagacg ggcctcccag gcggagcgaa ccctccacct cccaccccgc gccgggctgc     2160

cgcgctccgg aacccaaatt cccgccccga ggctgccggg ggaagcgaga ggcgcggagc     2220

ccacgcccgg gactccagcg gaggaaacgc agaccaaggc gcagcgccgc gcacccaccg     2280

ccagggggca gctcctacgg cgccggacag gggcggcgcg ggaggggagc ggggctgagg     2340

ggaccgggag ggcgggaggg gacctgcgac tgaggggaca gggagggcgg gaggcgaccc     2400

gcggctgagt gagggaaggg cgggagggga cccgcggctg aggggaccgg gagggcggga     2460

ggcgacccgc ggctgagtga ggggagggtg ggaggggacc cgcggctgag gggacaggga     2520

gggcgggagg ggacccgcgg ctgaggggac cgggagggcg ggaggcgacc cggggctgag     2580

tgaggggagg gcgggagggg agcggggctg aggggaccgg gagggcggga ggggacctgc     2640

gactgagggg acggggagga tgtgaggcga tccggggctg agtgagggga gggtgggagg     2700

ggacccgcgg ctgaggggac ggggagggcg ggaggggacc cgcggctgag gggacgggga     2760

gggcgggagg cgacccgggg ctgaggggac ggggagggcg ggaggggacc cgcggctgag     2820

gggacaggtc ctgcgtgcgg gctggggaga caggcgggcg agggtagggg tgcacaaggc     2880

tgtgtggttt gtgggctgtt gtgcagggtg ggtccaagca tgtgggggca ggcttgtcct     2940

ggggatgcag tgcccagggt tggtggatgg ggctgagagg accagcattt gagctggagg     3000

gcaggaaggt gactccagtc tgagaccagg acttggatgc agctccactg gaactcaccc     3060

tatcctggga gccacctggg cacctgtcct gcagatgcag gatttgaacc caggtttggc     3120

aactcagttc ccactcttct gctatgaatg ctgggtcaga aggattctca aaacaccctg     3180

gcttatctca cctgatggtt cctgaccaag accacagggt accctcccct ggtggaggtc     3240

catggggcca tgctaggctg gagttcaggg atggctcagc ggtatgaagg agcactggat     3300

gctgaatgga ccccagggtg ccccgaatgc tctcccggtc ttgaggcacc actttcctac     3360

ccttctctac ttctctcctt ttcctaccct tctctacttt tttctttcct acatttgtgt     3420

ccctgccaca ctgtgaactc agccatatct tcctcttccc tctttgcttt ggggaaagct     3480

agcaaagttc atctcaggta cagtacaagt tacttttctg ttcgattagt gacctcatac     3540

ttcccccatc taaaggacac cttagacttc agcattctgt ctgtgcagaa atctcctaca     3600

cccatcctgc ctccctgccc aagcttgtga aaagcttgct gcagatgctg cagggggata     3660

gggatccaca tagccctgca aggccttcag gagcttctgg gggctgcttt gtgtgtgagc     3720

tgcacttggc caagccaagc tctggcagtt gcagtggctg ctccctgtgg cttcctatcc     3780

ctcattcatg ctccatatct cctcagtaac catctggcaa aaagcttcgt ggcaacacct     3840

ggctcagaag ccgatatcat cccagactaa gctctgccct ccagggttgc acgtgtgggt     3900

ttgctccctg gttcttggcc ttatacctga atgtgtctca gagcacttgg cctgctctct     3960

tggcctgcca actatgttct aggagggctc tgtgctccag gctgtgattt ggacaactgg     4020

ctggtggccc tcagccagtg aaaggcctct ttccacacac ctggggactg gcagtcacac     4080

ctcagtggca ctgacagagg cctgcttcaa ggcagatgcc tattccaaag gaaatccagc     4140

ttgacaaggc ttgggagacc ccaggagggt gccacaatgt ggccccttct gggctatagc     4200

agacagactc tagaatggct cccttgaccc ccacctgctg gtatgcatgc ccttgtgtga     4260

tctcaccttg agtgtgtgca ggacctgtgc cttgttgtaa ccaatagaat acagaggtaa     4320

ggggatgtca ctcctgtgac accttgtgat catgtgacat aagattataa cattatcaag     4380

gaatagcagt ctatcccttg ctagctttaa aaagtgagct gctaggctat gagctgtcct     4440

atgaagaggc ccatgtagca gggtactggg gttgcctcca gcccccaact agcaagaaac     4500

tggggccctc aatcatccca tccacaagga gttgagtgtg gctagcaaca acgtgagctt     4560

cagaagtggc tgctttcctg gtcatacctg aaggggagac cacagcccca gctgacatct     4620

tgattgtagc ctaatgggac cttgagcaga gaacccaaca aagccacact tgggctcctg     4680

atccacagaa actgggagat cataaatgtg tgttgtttta agttgctaat ttgtagtgat     4740

gttcttatgc agcatagata actcatacac agagaaccaa ggccacgcga gaaccctgtg     4800

ggggcccctg ctgctcagcc actcctcaca tgctgggaca gctgtctctc tggcctctag     4860

caccaaggtc cccactatcc caggccttga ctcttggatc agagagggac aaaagcccca     4920

tggagccaag cagactcctc cccctgggct gcactcacct agcttgtctg gcacacacaa     4980

gttggagtag agaaggcagg aagccctggg aagggagagg gtgatggcct tgcttaactg     5040

ggatgagtgt ccaccaaatt tcccttccca cttcccctgc tcatgagccc ccaggggacc     5100

tgtgtcagtt cactttctag aggcttctat gtgccctaac ttggatgaca cccacgggcc     5160

tccccaactc agcacaggga acatatgccc atggtggcat ggggaaagaa cccagcctct     5220

cccctgccca ggctcctgca ccccatagct gtcacccctc tggaacctct cagggcagca     5280

cgagtggtag cctcggagtg gccttcaccc tccaggcact gcggtcctcc agattggctc     5340

acagcccagc tcttgctccc atatccacag ccatgagagc agccacctcc ccagggggcc     5400

ataagcgctt ctcaccagga gcccacctag gccaggaggg agctgggggc aagttccaac     5460

tgcccccttg aacactgcat acccatgaat ctggcagggg catctgggaa gagatttgac     5520

cactgaaaga ctgtagggaa acccttgaac ctcaatccgc tacgccacgt ggatttgctt     5580

cctgtgggct gcccaagagc gcctctgtgg tgaaggaagc ttctgaggat gggccactaa     5640

agatggccaa ggtcaccttt ctgtgctgtc cccactctgc actccatctc ccatcccaca     5700

ctgcctccag ctggagggag ggagggaggg ttgtacgtct gtgtccctgc cacactgtga     5760

actcagccct atcttccttg tcttcctcac agcctctggc tcagaggagg acctggacaa     5820

atggatgata ggtaggcaac cacccaaatg ttcctcattg actgttctct agagctgctt     5880

agtagagacc aggagtgtgt gggaggaaag ccctggtaaa cttcgaccct gagacagaag     5940

acctcagcag ccttcagcat gggatgcagc actttcttta ttgcccatcc agggaacagc     6000

caagccagct ccatctgcat tctggctgca gcgtgtacat taggggactc aggggccaca     6060

gtgtgggacc gtgcacactg gcaaggcact ggcggatgct ggcaggccag tggacatgga     6120

tagatgagaa tgacaactca cagatgtcct agcttctgct ggcccagctg ccagccactg     6180

gccatcaccc ttttgcccag catgtgtgca ttgtcaccca aaacatcttg aaacttgcca     6240

ttagtgaggc attcaacaaa gaagtaagct aagtgagtag gaaacagtgt ttcctggaat     6300

ataccgcact ctgcctgaaa taggaaaact atgtttgccg ggaagcagca gcagcaggaa     6360

agaagttata ccaaaaacga cttgtacacc acagacatta taaccctttc ctcaaagaaa     6420

cagtcatgtt ctgttgggta ttatggacag gtctctggaa atttatctaa taaagaccaa     6480

caaacttccc ca                                                         6492


<210>  48
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Pro Gly Cys Pro Val Gln Met Leu Lys Pro Leu Trp Lys Ala Ala 
1               5                   10                  15      


Val Ala Pro Thr Trp Pro Cys Ser Met Pro Pro Arg Arg Pro Trp Asp 
            20                  25                  30          


Arg Glu Ala Gly Thr Leu Gln Val Leu Gly Ala Leu Ala Val Leu Trp 
        35                  40                  45              


Leu Gly Ser Val Ala Leu Ile Cys Leu Leu Trp Gln Val Pro Arg Pro 
    50                  55                  60                  


Pro Thr Trp Gly Gln Val Gln Pro Lys Asp Val Pro Arg Ser Trp Glu 
65                  70                  75                  80  


His Gly Ser Ser Pro Ala Trp Glu Pro Leu Glu Ala Glu Ala Arg Gln 
                85                  90                  95      


Gln Arg Asp Ser Cys Gln Leu Val Leu Val Glu Ser Ile Pro Gln Asp 
            100                 105                 110         


Leu Pro Ser Ala Ala Gly Ser Pro Ser Ala Gln Pro Leu Gly Gln Ala 
        115                 120                 125             


Trp Leu Gln Leu Leu Asp Thr Ala Gln Glu Ser Val His Val Ala Ser 
    130                 135                 140                 


Tyr Tyr Trp Ser Leu Thr Gly Pro Asp Ile Gly Val Asn Asp Ser Ser 
145                 150                 155                 160 


Ser Gln Leu Gly Glu Ala Leu Leu Gln Lys Leu Gln Gln Leu Leu Gly 
                165                 170                 175     


Arg Asn Ile Ser Leu Ala Val Ala Thr Ser Ser Pro Thr Leu Ala Arg 
            180                 185                 190         


Thr Ser Thr Asp Leu Gln Val Leu Ala Ala Arg Gly Ala His Val Arg 
        195                 200                 205             


Gln Val Pro Met Gly Arg Leu Thr Arg Gly Val Leu His Ser Lys Phe 
    210                 215                 220                 


Trp Val Val Asp Gly Arg His Ile Tyr Met Gly Ser Ala Asn Met Asp 
225                 230                 235                 240 


Trp Arg Ser Leu Thr Gln Val Lys Glu Leu Gly Ala Val Ile Tyr Asn 
                245                 250                 255     


Cys Ser His Leu Ala Gln Asp Leu Glu Lys Thr Phe Gln Thr Tyr Trp 
            260                 265                 270         


Val Leu Gly Val Pro Lys Ala Val Leu Pro Lys Thr Trp Pro Gln Asn 
        275                 280                 285             


Phe Ser Ser His Phe Asn Arg Phe Gln Pro Phe His Gly Leu Phe Asp 
    290                 295                 300                 


Gly Val Pro Thr Thr Ala Tyr Phe Ser Ala Ser Pro Pro Ala Leu Cys 
305                 310                 315                 320 


Pro Gln Gly Arg Thr Arg Asp Leu Glu Ala Leu Leu Ala Val Met Gly 
                325                 330                 335     


Ser Ala Gln Glu Phe Ile Tyr Ala Ser Val Met Glu Tyr Phe Pro Thr 
            340                 345                 350         


Thr Arg Phe Ser His Pro Pro Arg Tyr Trp Pro Val Leu Asp Asn Ala 
        355                 360                 365             


Leu Arg Ala Ala Ala Phe Gly Lys Gly Val Arg Val Arg Leu Leu Val 
    370                 375                 380                 


Gly Cys Gly Leu Asn Thr Asp Pro Thr Met Phe Pro Tyr Leu Arg Ser 
385                 390                 395                 400 


Leu Gln Ala Leu Ser Asn Pro Ala Ala Asn Val Ser Val Asp Val Lys 
                405                 410                 415     


Val Phe Ile Val Pro Val Gly Asn His Ser Asn Ile Pro Phe Ser Arg 
            420                 425                 430         


Val Asn His Ser Lys Phe Met Val Thr Glu Lys Ala Ala Tyr Ile Gly 
        435                 440                 445             


Thr Ser Asn Trp Ser Glu Asp Tyr Phe Ser Ser Thr Ala Gly Val Gly 
    450                 455                 460                 


Leu Val Val Thr Gln Ser Pro Gly Ala Gln Pro Ala Gly Ala Thr Val 
465                 470                 475                 480 


Gln Glu Gln Leu Arg Gln Leu Phe Glu Arg Asp Trp Ser Ser Arg Tyr 
                485                 490                 495     


Ala Val Gly Leu Asp Gly Gln Ala Pro Gly Gln Asp Cys Val Trp Gln 
            500                 505                 510         


Gly 
    


<210>  49
<211>  8405
<212>  DNA
<213>  Homo sapiens

<400>  49
gccacatgaa acattctctg cctctgaagg ctccagaggc tgtgggaagc agcacatcag       60

cgacagctcc tggctgctgg actccgcagg gagggaagga agattggtcg caatgtccca      120

gcagaagtgc atcgtgatct ttgccctggt gtgctgcttt gccattctgg ttgcactgat      180

cttttcagcc gtggacatca tgggagagga tgaggatgga ctctcagaaa aaaattgcca      240

aaataaatgt cgaattgccc tggtggaaaa tattcctgaa ggccttaact attcagaaaa      300

tgcaccattt cacttatcac ttttccaagg ctggatgaat ttactcaaca tggccaaaaa      360

gtctgttgac atagtgtctt cccattggga tctcaaccac actcatccat cagcatgtca      420

gggtcaacgt ctttttgaaa agttgctcca gctgacttcg caaaatattg aaatcaagct      480

agtgagtgat gtaacagctg attcaaaggt attagaagcc ttgaaattaa agggagccga      540

ggtgacgtac atgaacatga ccgcttacaa caagggccgg ctgcagtcct ccttctggat      600

cgtggacaaa cagcacgtgt atatcggcag tgccggtttg gactggcaat ccctgggaca      660

gatgaaagaa ctcggtgtca tcttctacaa ctgcagctgc ctggtcctag atttacaaag      720

gatatttgct ctatatagtt cattaaaatt caaaagcaga gtgcctcaaa cctggtccaa      780

aagactctat ggagtctatg acaatgaaaa gaaattgcaa cttcagttga atgaaaccaa      840

atctcaagca tttgtatcga attctccaaa actcttttgc cctaaaaaca gaagttttga      900

catagatgcc atctacagtg tgatagatga tgccaagcag tatgtgtaca tcgctgtcat      960

ggactacctg cctatctcca gcacaagcac caaaaggact tactggccag acttggatgc     1020

aaaaataaga gaagcattag ttttacgaag cgttagagtt cgactccttt taagcttctg     1080

gaaggaaact gatcccctta cgtttaactt tatttcatct cttaaagcga tttgcactga     1140

aatagccaac tgcagtttga aagttaaatt ttttgatctg gaaagagaga atgcttgtgc     1200

tacaaaagaa caaaagaatc acacctttcc taggttaaat cgcaacaagt acatggtgac     1260

agatggagca gcttatattg gaaattttga ttgggtaggg aatgatttca ctcagaatgc     1320

tggcacgggc cttgttatca accaggcaga tgtgaggaac aacagaagca tcattaagca     1380

acttaaagat gtgtttgaaa gggactggta ttcaccgtat gccaaaacct tacagccaac     1440

caaacagccg aactgctcaa gcctgttcaa actcaaaccc ctctccaaca aaactgccac     1500

agacgacaca ggcggaaagg atccccggaa cgtataacat gatgaagaaa ctgacaggac     1560

agctctgtat ttcatattta tacataaagg acttgaggag agaaaaaaca ctttaatatg     1620

tctctttttt tagggaaaaa gcacacttat aaaaaatatt ctctgaacaa cacataatac     1680

ctatctaaca atatcttagc gtcgtgtaca ctaaaattaa gacttttgta tttgttacct     1740

ctgacagaga atgtcattct ggcgtagaag ttagttttta cgtttgcata caaattttaa     1800

gactttcatt cctgctcctt tctagtttta gaactttttc tgctgaccta cccggtcagt     1860

tgttaggaag cttagcatga ggtgggctct ttaacaccat tctgagaact gttgatttag     1920

agaggaaggt gaggattttg ccttggagaa gagactgata aaaccaagtg tttattcttg     1980

taaatcgtct ccaagaccta cacagtcagc taagcatgaa tagcttacat ctcatgccag     2040

ccttcaacac ccttgaaaaa tatccttttc tgtcttgctc attttcttct tataccataa     2100

gttttatttg gtatcatttt ctcttctcac aaaatgttcc tattatatag cattttctgt     2160

attcacctca acattacttc taactatgat aacatctttt gaaaacatac aaatttttca     2220

gaatggatac taagtggaaa tagcagtctt tcattttcac ctttcaactg aatccttttt     2280

tcccctaccg aattggtatt taaaaaaaat cacagtcagc aatatgtatc ctttctctca     2340

agctcagaaa aattatgtag ccacctgcta atatccagca agctatcaag tctgcatttt     2400

gggaataaag tagtttttca catttttgtt cagtttatgg tattataaag gaaaaaatct     2460

ctatgcgtca gtggatttta atttctttag aatcattatg ctgttaagag tatgccagca     2520

aacgtttcta gagctattta atataccttc tgctatttaa tataccaaat gcttttcaga     2580

gaaatgcaat ttaaatactg tgcttaacat attttactaa gaagcagaaa tattgaatta     2640

ttgttctata acgtaattgt gtgttgttgt tttatatcta tacaatatat acccctgtat     2700

taatggagac cattgctaca ctagggagag gcatggcctc ttcagagccc acagcaggtg     2760

gccgggatgt ccagttccaa tgttgttccc gactctgtga ctcaaagcgg agcccctcac     2820

tgcttggcct cgggcttctc ttggtaatgt agacggtaat aactcaccta cctcgcaagg     2880

atgttgtcac ggtaggaaat atttataact tgttttgaaa tcaaaagaac ctatataaat     2940

gctaagcatt ataatatata atctttttct tgaaataaac tttgtcatat cttgatggaa     3000

tcaacaccag gtcctccccc agaatccaca aaggaaaaca aattcacagc ttcctgttgc     3060

aaatgtggat gaaaagagca cagccccaca gaaaccctgg tggagatctg gattgtcaac     3120

atttcaatag aacattgcgt tgggctgctt tggcatgaat aacatcaaca caaaactaga     3180

cgtcgtgcta gagctggttc ttcaggacca taatatacat gtattttcag agcaaggaaa     3240

cactcagtta ttctttttca tttctggaga cttgatttct aaatgccaaa agagtgatcg     3300

aggagcctgt gaatcttatc caatggattt acttaatata gaatggctat gttggttatc     3360

cagtgagtga tcacattact tcccttcttg ttatttgcaa gtattgcttc actagatatt     3420

taaccagttg atcaagagag ctggaaggaa gctgtatttt taagggtagc atggttttat     3480

gactaattgg gagattctca ctgaaattct tcatcaataa tagccagtcc ctaagactct     3540

aaatatttac catatacaca atccatattt gagttgggag ttataactct gccagttatc     3600

ccaataaagt aaacgtggct ttggtgatga ttttaaaaag aaagcagcct gggtgcggtg     3660

gctcacgcct gtcatcccag cgctttggaa ggccaaggca ggaggattgc ttgaggccaa     3720

gagtttgaga ccagcctggg tagcatagca agatcctgcc tctaaaaata aataaataca     3780

gaaaggaaag aaggaatcag aataggagtg gagacaaacc taccaagttc acactcagac     3840

aaacaaaagc gacctgagtt ggttttaaaa aggacatcta aagggagaaa aaaaaaccaa     3900

ataaactaaa atttgttagt tctcaagttg tcccctgaag tattcatcca cagccatggg     3960

acactcatag gcttggtgtc atggggcccc ttcactgtca ctatctgctg tatgtgctac     4020

gagaagagaa tgtcatccat tacggaatga ccatcattgc catttccttt tgaggcctgg     4080

caaaatgcta tcaccaggag ccgcatccca ggcttttctg ccaagcagca gcagcagatg     4140

cctaccagac acagcaagcc cctaatcagg ggagtctggg cagcggtggt gactccatgg     4200

ggccacactg tccttctgtg gcagccagaa aagtgacccc cataccaaga gtgtcagaaa     4260

tgggttcatg tctcccaaga gaacatttca ttctgcagaa ctttctttca tttggatgct     4320

ttagctatcc ctctagagac ggctttcctt tcttttagac ttgtttctgt gctaaacaaa     4380

ctatcaacct ccattccccc ccacccctaa atatcccagg aattactttc caggagggaa     4440

agaatgcaaa acaaaaacag gttaatttga caccctctgg tggatgtcca tgccagaaat     4500

tatgaggagc agggtgacta ctccccatta acattcctgg atttatttcc caagaggcaa     4560

aaaggaaaac aaacacaatt agagactata tcttggattt cagtaccact aacactaact     4620

tagtgcctta tgtatcctca agtgttgatt ttaaacaatg acttattcta tgagaacact     4680

tctctctcct gtggaattca aatgaccttc cgatgggcct accagttgaa aacttccatt     4740

tgagcagtga cagtttttat gctgcctgtt ctcttcccaa gccccatcac ctttatccac     4800

ccccccgcca aatcaaatca ttgcacacac catcaaagat caatactgtg ggcctccact     4860

gcattgtcac tggccactag cctatcaaat aattgaatct ctgcttgtcc aaccattgga     4920

gaggaagtgg aagagtgaga tgacatccat gctttgtaaa caacaagctt taggtacctg     4980

aacctgatag aaacaaggaa tgctgaaaat gtccccactg acttaaaaga atgctgtaaa     5040

gagatgcttt gcagacttcc taggtcctgt ggcacagaga atgaaaacca gcgtctttaa     5100

caagtcaaag cagacaaaga aacaaaaggt ctgcggatac actttgcacc tgtgtaactc     5160

tgggcaccat tcgggccctc tctgtgctac tgtttgtctc atgtctgaat ggttcttggt     5220

gagaggggtc tgatcacatt tttggttgat ctcacccttt gaaaaatgtg ggggattttt     5280

tttgaaatgc agttaatggt ttaagtgcct cgatgaacct gggatggata gaagctcatt     5340

tcccaccagc ctgtggctat actcagtgac tctgattcat tctgtttgtt tttaggaact     5400

tttattgaac taaattccaa ggggggagaa aagaccataa gaatttcttg ataagatcag     5460

atccagggtc tatctgtctc aggaattcta tcctacaatt aacttttttt tttttccaca     5520

cgtatgacca ctggtgtgtg tttctgtgtc caaaattcat ttcattattt ttaactttag     5580

gaatgtaaaa cgctgccatt acttgcatag aacagccact tcctataatg aaagatactt     5640

tgttattgtt tattcaaact cagtccttac gaacagcccc atatattgtg gacaaatgtt     5700

tcattctttt atctttctgt acttgttccc aatgaactgg tgtgctttat tatacacctt     5760

ttaaaggcaa aattaatata acttccattt ggcccaaggt aaaaaatttt ccaatttgat     5820

ttggattagc atctttcatt ttccttttat atgttgttaa caaaatagct gcttaccatt     5880

ttcaccttat tgacttaaat ggacggaggc ttttgaatag ccctgacatc aaccccagtt     5940

cgcagcctgt ctttctcatt tgagagaatt cccatctttg gctgaattat gaagatgctg     6000

ctttatacag tgactcaatg ggtattcctc agaagtttct tgaagatgta aaaatgaaat     6060

tttcttattt ttgacccatt agcagtcttg tatttacaag gttctaaaac ttcactggtc     6120

attaacgctt cttttggcaa tttgaaaaaa aaaagttaca tttaatagac tattacacat     6180

tttcttttgc tatgttcaac tactaaactt ctaattctgt tacaaaaggt atcttgaatt     6240

tttaatgttc ctttatgtaa ataggataaa cttgtacctg gacatatcta tattattaac     6300

cttaagatcc ctaaataaat gggtttgata aagggttgaa tttgggggaa tcattaaaat     6360

tatcaaacct ttcgtataac cagatgctca gttttttcag aagtaaatat tagatggctt     6420

tttcatactg tgagatgagg catttctttt tctcctcaag ctgatctcag aaacaaatca     6480

gtctctcatc agtaaccaag ctgtactgtg gtaaattatg aagaaggtag atgcgactgg     6540

tccaatgggc ccactgtttt gtatattcac acaaggaggc atctttgaaa cactatacct     6600

atctctttct ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa cctttccaat aaatgttcat     6660

tctgagtaca ttaattttta gtgagaaaaa gaaacaatca tagagacccc actagagaac     6720

ctagtgtctg ctcagcaaac ccatattgag ctgtagagca tactttaaca gccatctcaa     6780

ccagctcacc caacgtgtaa attcccttcc catttgggca tagaagttga cagcctagag     6840

tgtcaggacg gccgagtggt ctgaggctcc agactcaagg tgagaagctg aaaacctact     6900

tgagccaaac aatttggagt gctttatatg gttcctttct caagacccac acaggataaa     6960

attttgttga tttactaaag taatttggat ttgaggcagt cttatctctg aaaggatatg     7020

cacagcatgt aataaggtgg gtgctgtttt cataaagaga atcaatctga gaggcatact     7080

tttaaaaaaa aaactatcat tggagaggtt agcaaaggct taaaagtgaa ctttgagtct     7140

gcaatagtca atagtattct gattttattg gcagtttctg aatgctacaa tttcgtgttt     7200

ttttttaaaa aaatgggcta acagtgcgat gacagtcatg tacaaggagt ccaattaaat     7260

catagtaagg gtgaagatta tttgtgattt atttttatat gagagataaa ttagtaagga     7320

gaaaagatct ctttttatga agtggatatc tggctctcaa acccattcct tttggctcag     7380

acattaaaaa attattaatt cccttatgga ctctcctatt ccccatgggc ggaaaattct     7440

gaaaagcaga tgagacattc tgagcccctt gcaagacaaa cacagatggt ttctaattta     7500

gagttttccc acacaaatgc acaaccaatc ttggaaatat gacctcaatt cccaggatta     7560

aaaacgttga aattatatgt tactttccaa tataaataga ggatgaagat ctttaaagac     7620

aactcagaaa atatgatcca ataacattca aatcagagcg taatctacaa tttcacttaa     7680

tagttaaaag tgaagattag ctgcttcttt aaaaggggtg agttattaaa ggcaacatcc     7740

tagaaaatgt aataacaaga aggcaacacc atattttcag caaagttatg gtactgataa     7800

agcactttga aaatcctctg taggaaaatg tcattgagaa acaaaggcca atttgtctcc     7860

agtgataaag ctatctctca ttcatatttc ataggtggat ctatagtttt cctggtgtct     7920

tggagagacc ctacctccac agctcctgca ggagcaaaac catgttttct gccatgtgag     7980

ctctctacac tggccacagc tgattgtacc aaggttcagt acccgaccca aagagactca     8040

ttttcaggcc agagggcggc ctaaggaatg aaagtgtacc tagcagtggt attcttgttt     8100

gatggtacct ggccccacca atcacggccc tcttttaggg agtttgaaca ccagaaagta     8160

aatgatgaat aggaagcaca gccagaatag acacagtcac cgtaatggtg actctgagaa     8220

cagtgacagc agttacttct gcagtcaaga caatttgagg tcttgttgat tcaccattct     8280

gctcttagct tactggagaa atacttgact cctgaacaat gagtctggac tttgtagttc     8340

ctgggttgct tttttttttt cttcctttct tatgtattga cataaataaa ctcacattaa     8400

ctgaa                                                                 8405


<210>  50
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ser Gln Gln Lys Cys Ile Val Ile Phe Ala Leu Val Cys Cys Phe 
1               5                   10                  15      


Ala Ile Leu Val Ala Leu Ile Phe Ser Ala Val Asp Ile Met Gly Glu 
            20                  25                  30          


Asp Glu Asp Gly Leu Ser Glu Lys Asn Cys Gln Asn Lys Cys Arg Ile 
        35                  40                  45              


Ala Leu Val Glu Asn Ile Pro Glu Gly Leu Asn Tyr Ser Glu Asn Ala 
    50                  55                  60                  


Pro Phe His Leu Ser Leu Phe Gln Gly Trp Met Asn Leu Leu Asn Met 
65                  70                  75                  80  


Ala Lys Lys Ser Val Asp Ile Val Ser Ser His Trp Asp Leu Asn His 
                85                  90                  95      


Thr His Pro Ser Ala Cys Gln Gly Gln Arg Leu Phe Glu Lys Leu Leu 
            100                 105                 110         


Gln Leu Thr Ser Gln Asn Ile Glu Ile Lys Leu Val Ser Asp Val Thr 
        115                 120                 125             


Ala Asp Ser Lys Val Leu Glu Ala Leu Lys Leu Lys Gly Ala Glu Val 
    130                 135                 140                 


Thr Tyr Met Asn Met Thr Ala Tyr Asn Lys Gly Arg Leu Gln Ser Ser 
145                 150                 155                 160 


Phe Trp Ile Val Asp Lys Gln His Val Tyr Ile Gly Ser Ala Gly Leu 
                165                 170                 175     


Asp Trp Gln Ser Leu Gly Gln Met Lys Glu Leu Gly Val Ile Phe Tyr 
            180                 185                 190         


Asn Cys Ser Cys Leu Val Leu Asp Leu Gln Arg Ile Phe Ala Leu Tyr 
        195                 200                 205             


Ser Ser Leu Lys Phe Lys Ser Arg Val Pro Gln Thr Trp Ser Lys Arg 
    210                 215                 220                 


Leu Tyr Gly Val Tyr Asp Asn Glu Lys Lys Leu Gln Leu Gln Leu Asn 
225                 230                 235                 240 


Glu Thr Lys Ser Gln Ala Phe Val Ser Asn Ser Pro Lys Leu Phe Cys 
                245                 250                 255     


Pro Lys Asn Arg Ser Phe Asp Ile Asp Ala Ile Tyr Ser Val Ile Asp 
            260                 265                 270         


Asp Ala Lys Gln Tyr Val Tyr Ile Ala Val Met Asp Tyr Leu Pro Ile 
        275                 280                 285             


Ser Ser Thr Ser Thr Lys Arg Thr Tyr Trp Pro Asp Leu Asp Ala Lys 
    290                 295                 300                 


Ile Arg Glu Ala Leu Val Leu Arg Ser Val Arg Val Arg Leu Leu Leu 
305                 310                 315                 320 


Ser Phe Trp Lys Glu Thr Asp Pro Leu Thr Phe Asn Phe Ile Ser Ser 
                325                 330                 335     


Leu Lys Ala Ile Cys Thr Glu Ile Ala Asn Cys Ser Leu Lys Val Lys 
            340                 345                 350         


Phe Phe Asp Leu Glu Arg Glu Asn Ala Cys Ala Thr Lys Glu Gln Lys 
        355                 360                 365             


Asn His Thr Phe Pro Arg Leu Asn Arg Asn Lys Tyr Met Val Thr Asp 
    370                 375                 380                 


Gly Ala Ala Tyr Ile Gly Asn Phe Asp Trp Val Gly Asn Asp Phe Thr 
385                 390                 395                 400 


Gln Asn Ala Gly Thr Gly Leu Val Ile Asn Gln Ala Asp Val Arg Asn 
                405                 410                 415     


Asn Arg Ser Ile Ile Lys Gln Leu Lys Asp Val Phe Glu Arg Asp Trp 
            420                 425                 430         


Tyr Ser Pro Tyr Ala Lys Thr Leu Gln Pro Thr Lys Gln Pro Asn Cys 
        435                 440                 445             


Ser Ser Leu Phe Lys Leu Lys Pro Leu Ser Asn Lys Thr Ala Thr Asp 
    450                 455                 460                 


Asp Thr Gly Gly Lys Asp Pro Arg Asn Val 
465                 470                 


<210>  51
<211>  2578
<212>  DNA
<213>  Homo sapiens

<400>  51
agactccgct gcggcggcgt ggctgtgggt cccggattag cggcggcatg ggacggttga       60

gttggcaggt ggcggccgcg gcggctgtgg gcctggctct gactctggag gcgctgcctt      120

gggtgctgcg ctggctgcgg tccaggcggc ggcggccgcg gcgcgaggcg ctgttcttcc      180

cgtctcaggt gacctgtacc gaggccctgc tgcgggctcc gggcgcggag ctggccgagc      240

tccccgaggg ctgcccgtgc ggcctgcccc acggcgagag cgcgctaagc cgcctgctgc      300

gtgccctgct ggccgcccgc gccagcctgg atctctgcct gttcgccttc tccagcccgc      360

agctgggccg cgccgtgcag ttgctgcacc agcgtggggt gcgagtgcgg gtcgtcaccg      420

actgcgacta catggccctc aacggctcgc aaatcggtct gctgcgcaag gcagggatcc      480

aggtccggca cgatcaagac ccaggctaca tgcatcacaa gtttgccatc gtggacaaga      540

gggtgctcat cactggctcg ctcaactgga ccacgcaagc catccagaac aacagggaga      600

atgttctcat cacggaggac gacgagtacg tgcggctttt tctggaagaa tttgagcgca      660

tctgggaaca gtttaaccct acaaagtata cctttttccc accaaagaaa agtcacggaa      720

gctgtgcccc acctgtctcc agagctggag ggagattgct ttcatggcac agaacttgcg      780

gcacctccag cgaaagccaa acctaaccaa gaatggggct gagccctccc tgcgggctgc      840

tgtgcgttct gagggaggga gacctcggca ctagaaaaaa atcgttaaac taaagtctcg      900

tctattagaa tactaaattg aactaaagaa ggttaggaaa gggaaatttc tgttacttcg      960

ggtcagttat ttcgggccag acctttttct tgctcctttg ccaaaataac ttcagtcacg     1020

acctgccacg gggtgctttc atgagtgtgg tccgtatctt ggtttggaat cgaaacttct     1080

gctacagcac agaaaaggca cagtgcctct tccaggtcga tcccattccc ttccctgatt     1140

ctagaaaagt ccctcctgct ttggctgatg tgggcccttt cagcatctcc ctgagatttc     1200

atccctctct ccatgtggca cgactggggt tggttggggc ctacagtctc cttgtccctc     1260

acagtctgcc cctgtcaggg ctcggtcctc agagtaagga aaggaaatgg aagtcaggag     1320

gaagggaaga tgtgagtgtg cggtgcgggt ggcaaaagca gccttcgggg caaccccgtg     1380

agcgtcattg ccaccaaagg ctggctgttc ccttgattcc ttgcataatt gctctttaaa     1440

accagtatgc acgccagtgc caagctcttc agcagcctgt ccttgggtag taagtgctgt     1500

ggtctgtcag gactgatggc cagcagctgt ttctatgttg ggcttttaac tttttttatt     1560

ttatttattt atttatttat cttttttgag atggagtctc actctgtggc ccaggctgga     1620

gtgcagtggc acaacctcgg ctcactgcat cctctgcctc ctgggttcaa acgattgtcc     1680

tgcctcagcc tcccgagtag ctgggattac aggtgcctgc cacaacacct ggctgatttt     1740

ttttttggta tttttagtag agacagggtt tcaccatgtt ggttaggctg gtctcaaact     1800

cctgacctca agtgatccac cacttccgcc tcccaaagtg ctgggattac aggtgtgagc     1860

cgccatgccc ggccgggctt ttaactttta atgtcctaat gttaaggtaa ttttgttgtg     1920

tgtttagaag tgaccttacc tttaacacct gtggagttag tgcgtgcaca ttgctggctc     1980

agcgtaaccc atcacgggac cggaggagag gagagcgggg aagaggagag cagcttcagg     2040

ccgtggtgtc tcccacgtct gtgttcttat ttgcagctca gggtttgcat tcccaggtag     2100

aacaggtgtc gtacactgtg aaatgttcca ggttatttgt ttataatgtg tgtgtcatat     2160

acagatagct ccgatgacat ctgaagttgt gacttcatca tcttgtcata tttctgtatg     2220

atgagcccca gggcccatcc tgaggtctgc tagccatgtg cttagtctca cctccccagc     2280

ccacgctggc attaccaccc agagaccctt cagtgctgtg tgtttttcct ttttagggtt     2340

acttttgact cacagtgtta ggcaagccag cttggaagtt aacttttaaa aaaattcaat     2400

tgaagctgta aagtataata tatagattgg aagtcaccag aaattgtttt agtttgtgaa     2460

ttcccccagt gtatgttctg aaaagaaaat gggagagctt gtaaagcatc tcctaaatgc     2520

gaagccgcgt gaccctggac ttctggcaca tctgaataaa catgttctta ttctggaa       2578


<210>  52
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Gly Arg Leu Ser Trp Gln Val Ala Ala Ala Ala Ala Val Gly Leu 
1               5                   10                  15      


Ala Leu Thr Leu Glu Ala Leu Pro Trp Val Leu Arg Trp Leu Arg Ser 
            20                  25                  30          


Arg Arg Arg Arg Pro Arg Arg Glu Ala Leu Phe Phe Pro Ser Gln Val 
        35                  40                  45              


Thr Cys Thr Glu Ala Leu Leu Arg Ala Pro Gly Ala Glu Leu Ala Glu 
    50                  55                  60                  


Leu Pro Glu Gly Cys Pro Cys Gly Leu Pro His Gly Glu Ser Ala Leu 
65                  70                  75                  80  


Ser Arg Leu Leu Arg Ala Leu Leu Ala Ala Arg Ala Ser Leu Asp Leu 
                85                  90                  95      


Cys Leu Phe Ala Phe Ser Ser Pro Gln Leu Gly Arg Ala Val Gln Leu 
            100                 105                 110         


Leu His Gln Arg Gly Val Arg Val Arg Val Val Thr Asp Cys Asp Tyr 
        115                 120                 125             


Met Ala Leu Asn Gly Ser Gln Ile Gly Leu Leu Arg Lys Ala Gly Ile 
    130                 135                 140                 


Gln Val Arg His Asp Gln Asp Pro Gly Tyr Met His His Lys Phe Ala 
145                 150                 155                 160 


Ile Val Asp Lys Arg Val Leu Ile Thr Gly Ser Leu Asn Trp Thr Thr 
                165                 170                 175     


Gln Ala Ile Gln Asn Asn Arg Glu Asn Val Leu Ile Thr Glu Asp Asp 
            180                 185                 190         


Glu Tyr Val Arg Leu Phe Leu Glu Glu Phe Glu Arg Ile Trp Glu Gln 
        195                 200                 205             


Phe Asn Pro Thr Lys Tyr Thr Phe Phe Pro Pro Lys Lys Ser His Gly 
    210                 215                 220                 


Ser Cys Ala Pro Pro Val Ser Arg Ala Gly Gly Arg Leu Leu Ser Trp 
225                 230                 235                 240 


His Arg Thr Cys Gly Thr Ser Ser Glu Ser Gln Thr 
                245                 250         


