                               SEQUENCE LISTING

<110> Guardian Therapeutics, LLC
 
<120> GPC3 APTAMERS AND VARIANTS AND USE THEREOF

<130> 2125.1001PCT

<140> PCT/USXXXX/XXXXXX
<141> 2021-11-12

<150> 63/113,640
<151> 2020-11-13

<160> 83    

<170> PatentIn version 3.5

<210> 1
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (24)..(53)
<223> a, c, t, g, unknown or other

<400> 1
gggagacaag aataaagcga gttnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnaagagtc       60

gatgatgctt agctag                                                       76


<210> 2
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 2
taatacgact cactataggg agacaagaat aaagcgagtt                             40


<210> 3
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 3
ctagctaagc atcatcgact ctt                                               23


<210> 4
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (23)..(52)
<223> a, c, t, g, unknown or other

<400> 4
gggagtccta cgtacagtct agnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntcgatgca       60

ggatctagct atcgat                                                       76


<210> 5
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 5
taatacgact cactataggg agtcctacgt acagtctag                              39


<210> 6
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
atcgatagct agatcctgca tcga                                              24


<210> 7
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, t, or g

<220>
<221> misc_feature
<222> (3)..(3)
<223> The nucleotide at this position forms a base pair with
      the nucleotide at position 12

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, or g

<220>
<221> misc_feature
<222> (12)..(12)
<223> The nucleotide at this position forms a base pair with
      the nucleotide at position 3

<400> 7
cgngttgcta cncrag                                                       16


<210> 8
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
gggagacaag aataaagcga gttgctactc aaggcacgtc gtgtgcgctg attcaagagt       60

cgatgatgct tagctag                                                      77


<210> 9
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
gggagacaag aataaagcga gtttcgtgtc gtgttgctac acaagtccgt taccaagagt       60

cgatgatgct tagctag                                                      77


<210> 10
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
gggagacaag aataaagcga gttaacgggt tgctacccaa gtcttgcaat tcgcaagagt       60

cgatgatgct tagctag                                                      77


<210> 11
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
gggagacaag aataaagcga gttgcatgat cgtgttgcta cacgaggtct cattaagagt       60

cgatgatgct tagctag                                                      77


<210> 12
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
gggagacaag aataaagcga gtttgaagcc attaccgggt tgctacccaa ggacaagagt       60

cgatgatgct tagctag                                                      77


<210> 13
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
gggagacaag aataaagcga gttgttgcat cgagttgcta ctcaaggtcg cgtcaagagt       60

cgatgatgct tagctag                                                      77


<210> 14
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
gggagacaag aataaagcga gttgcctgtt gcatcgtgtt gctacacaag attgaagagt       60

cgatgatgct tagctag                                                      77


<210> 15
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
gggagacaag aataaagcga gttcatcgtg ttgctacaca aggactctag caccaagagt       60

cgatgatgct tagctag                                                      77


<210> 16
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
gggagacaag aataaagcga gttgttgacg ggttgctacc cgagtcttgc attcaagagt       60

cgatgatgct tagctag                                                      77


<210> 17
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
gggagtccta cgtacagtct agatcgggtt gctacccaag ctgcggtaca aatcgatgca       60

ggatctagct atcgat                                                       76


<210> 18
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
gggagtccta cgtacagtct aggacgagtt gctacccaag tcccgcgttt gatcgatgca       60

ggatctagct atcgat                                                       76


<210> 19
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
gggagtccta cgtacagtct agatcgggtt gctacccaag ctgcggttca aatcgatgca       60

ggatctagct atcgat                                                       76


<210> 20
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
gggagtccta cgtacagtct agatcgggtt gctacccaag ctgcggttca catcgatgca       60

ggatctagct atcgat                                                       76


<210> 21
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
gggagtccta cgtacagtct agatcgggtt gctacccaag ctgcggtaca gatcgatgca       60

ggatctagct atcgat                                                       76


<210> 22
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
gggagtccta cgtacagtct agatcgggtt gctacccaag ctgcggttca gatcgatgca       60

ggatctagct atcgat                                                       76


<210> 23
<211> 39
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
cgucaucggg uugcuaccca aggacaagag ucgaugacg                              39


<210> 24
<211> 39
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
cgucaucggg uugcuaccca aggucaagag acgaugacg                              39


<210> 25
<211> 39
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
cgucaucggg uugcuaccca aggccaggag gcgaugacg                              39


<210> 26
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
aagccattac cgggttgcta cccaaggaca agagtcgatg atgctt                      46


<210> 27
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
aagcattacc gggttgctac ccaaggacaa gagtcgatga tgctt                       45


<210> 28
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
aagccattac cgggttgcta cccgaggaca agagtcgatg atgctt                      46


<210> 29
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
aagccattat cgggttgcta cccaaggaca agagtcgatg atgctt                      46


<210> 30
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
cattatcggg ttgctaccca aggacaagag tcgatgatg                              39


<210> 31
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
cattatcggg ttgctacccg aggacaagag tcgatgatg                              39


<210> 32
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
cgtcatcggg ttgctaccca aggacaagag tcgatgacg                              39


<210> 33
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
cgtcgtcggg ttgctaccca aggacaagag tcgacgacg                              39


<210> 34
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
ggcatcgggt tgctacccaa ggacaagagt cgatgcc                                37


<210> 35
<211> 39
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
cgucaucggg uugcuaccca aggucaggug acgaugacg                              39


<210> 36
<211> 39
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
cgucaucggg uugcuaccca aggucaggag acgaugacg                              39


<210> 37
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
gggagacaag aataaagcga gttgctactc aaggcacgtc gtgtgcgctg attcaagagt       60

cgatgatgct tagctag                                                      77


<210> 38
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
gggagacaag aataaagcga gtttcgtgtc gtgttgctac acaagtccgt taccaagagt       60

cgatgatgct tagctag                                                      77


<210> 39
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
gggagacaag aataaagcga gttaacgggt tgctacccaa gtcttgcaat tcgcaagagt       60

cgatgatgct tagctag                                                      77


<210> 40
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
gggagacaag aataaagcga gttgcatgat cgtgttgcta cacgaggtct cattaagagt       60

cgatgatgct tagctag                                                      77


<210> 41
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
gggagacaag aataaagcga gtttgaagcc attaccgggt tgctacccaa ggacaagagt       60

cgatgatgct tagctag                                                      77


<210> 42
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
gggagacaag aataaagcga gttgttgcat cgagttgcta ctcaaggtcg cgtcaagagt       60

cgatgatgct tagctag                                                      77


<210> 43
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
gggagacaag aataaagcga gttgcctgtt gcatcgtgtt gctacacaag attgaagagt       60

cgatgatgct tagctag                                                      77


<210> 44
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
gggagacaag aataaagcga gttcatcgtg ttgctacaca aggactctag caccaagagt       60

cgatgatgct tagctag                                                      77


<210> 45
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 45
gggagacaag aataaagcga gttgttgacg ggttgctacc cgagtcttgc attcaagagt       60

cgatgatgct tagctag                                                      77


<210> 46
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
gggagtccta cgtacagtct agatcgggtt gctacccaag ctgcggtaca aatcgatgca       60

ggatctagct atcgat                                                       76


<210> 47
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
gggagtccta cgtacagtct aggacgagtt gctacccaag tcccgcgttt gatcgatgca       60

ggatctagct atcgat                                                       76


<210> 48
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
gggagtccta cgtacagtct agatcgggtt gctacccaag ctgcggttca aatcgatgca       60

ggatctagct atcgat                                                       76


<210> 49
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 49
gggagtccta cgtacagtct agatcgggtt gctacccaag ctgcggttca catcgatgca       60

ggatctagct atcgat                                                       76


<210> 50
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 50
gggagtccta cgtacagtct agatcgggtt gctacccaag ctgcggtaca gatcgatgca       60

ggatctagct atcgat                                                       76


<210> 51
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 51
gggagtccta cgtacagtct agatcgggtt gctacccaag ctgcggttca gatcgatgca       60

ggatctagct atcgat                                                       76


<210> 52
<211> 39
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 52
cgucaucggg uugcuaccca aggacaagag ucgaugacg                              39


<210> 53
<211> 39
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 53
cgucaucggg uugcuaccca aggucaagag acgaugacg                              39


<210> 54
<211> 39
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 54
cgucaucggg uugcuaccca aggccaggag gcgaugacg                              39


<210> 55
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 55
aagccattac cgggttgcta cccaaggaca agagtcgatg atgctt                      46


<210> 56
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 56
aagcattacc gggttgctac ccaaggacaa gagtcgatga tgctt                       45


<210> 57
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 57
aagccattac cgggttgcta cccgaggaca agagtcgatg atgctt                      46


<210> 58
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 58
aagccattat cgggttgcta cccaaggaca agagtcgatg atgctt                      46


<210> 59
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 59
cattatcggg ttgctaccca aggacaagag tcgatgatg                              39


<210> 60
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 60
cattatcggg ttgctacccg aggacaagag tcgatgatg                              39


<210> 61
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 61
cgtcatcggg ttgctaccca aggacaagag tcgatgacg                              39


<210> 62
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 62
cgtcgtcggg ttgctaccca aggacaagag tcgacgacg                              39


<210> 63
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 63
ggcatcgggt tgctacccaa ggacaagagt cgatgcc                                37


<210> 64
<211> 39
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 64
cgucaucggg uugcuaccca aggucaggug acgaugacg                              39


<210> 65
<211> 39
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 65
cgucaucggg uugcuaccca aggucaggag acgaugacg                              39


<210> 66
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 66
tcgtcgtttt gtcgttttgt cgtt                                              24


<210> 67
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 67
tcgtcgtttt gtcgttttgt cgtt                                              24


<210> 68
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 68
tcgtcgtttt gtcgttttgt cgttcgucau cggguugcua cccaaggcca ggaggcgaug       60

acg                                                                     63


<210> 69
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 69
cggguugcua cccaag                                                       16


<210> 70
<211> 46
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 70
aagccauuac cggguugcua cccaaggaca agagucgaug augcuu                      46


<210> 71
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 71
aagcauuacc ggguugcuac ccaaggacaa gagucgauga ugcuu                       45


<210> 72
<211> 46
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 72
aagccauuac cggguugcua cccgaggaca agagucgaug augcuu                      46


<210> 73
<211> 46
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 73
aagccauuau cggguugcua cccaaggaca agagucgaug augcuu                      46


<210> 74
<211> 39
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 74
cauuaucggg uugcuaccca aggacaagag ucgaugaug                              39


<210> 75
<211> 39
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 75
cauuaucggg uugcuacccg aggacaagag ucgaugaug                              39


<210> 76
<211> 54
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 76
gacuagaucg gguugcuacc caagcuccgg uucagaucga uggaggaucu aguc               54


<210> 77
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 77
cgucaucggg uugcuaccca aggcccagga gggcgaugacg                               41


<210> 78
<211> 39
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 78
cgucaucggg uugcuaccca aggcaccagg aggugcgaug acg                             43


<210> 79
<211> 39
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 79
cgggaguccu aggaaggacg gguugcuacc caagucccg                                 39


<210> 80
<211> 54
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 80
gacuagaucg gguugcuacc caagcuccgg uucagaucga uggaggaucu aguc               54


<210> 81
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 81
cgucaucggg uugcuaccca aggcccagga gggcgaugacg                               41


<210> 82
<211> 39
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 82
cgucaucggg uugcuaccca aggcaccagg aggugcgaug acg                             43


<210> 83
<211> 39
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 83
cgggaguccu aggaaggacg gguugcuacc caagucccg                                 39