                         SEQUENCE LISTING

<110>  ICOSAVAX, INC.
 
<120>  PROTEIN-BASED NANOPARTICLE VACCINE FOR METAPNEUMOVIRUS

<130>  ICVX-011/01WO 333041-2077

<150>  US 63/113,686
<151>  2020-11-13

<160>  143   

<170>  PatentIn version 3.5

<210>  1
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  1

Glu Gly Met Asp Pro Leu Ala Val Leu Ala Glu Ser Arg Leu Leu Pro 
1               5                   10                  15      


Leu Leu Thr Val Arg Gly Gly Glu Asp Leu Ala Gly Leu Ala Thr Val 
            20                  25                  30          


Leu Glu Leu Met Gly Val Gly Ala Leu Glu Ile Thr Leu Arg Thr Glu 
        35                  40                  45              


Lys Gly Leu Glu Ala Leu Lys Ala Leu Arg Lys Ser Gly Leu Leu Leu 
    50                  55                  60                  


Gly Ala Gly Thr Val Arg Ser Pro Lys Glu Ala Glu Ala Ala Leu Glu 
65                  70                  75                  80  


Ala Gly Ala Ala Phe Leu Val Ser Pro Gly Leu Leu Glu Glu Val Ala 
                85                  90                  95      


Ala Leu Ala Gln Ala Arg Gly Val Pro Tyr Leu Pro Gly Val Leu Thr 
            100                 105                 110         


Pro Thr Glu Val Glu Arg Ala Leu Ala Leu Gly Leu Ser Ala Leu Lys 
        115                 120                 125             


Phe Phe Pro Ala Glu Pro Phe Gln Gly Val Arg Val Leu Arg Ala Tyr 
    130                 135                 140                 


Ala Glu Val Phe Pro Glu Val Arg Phe Leu Pro Thr Gly Gly Ile Lys 
145                 150                 155                 160 


Glu Glu His Leu Pro His Tyr Ala Ala Leu Pro Asn Leu Leu Ala Val 
                165                 170                 175     


Gly Gly Ser Trp Leu Leu Gln Gly Asp Leu Ala Ala Val Met Lys Lys 
            180                 185                 190         


Val Lys Ala Ala Lys Ala Leu Leu Ser Pro Gln Ala Pro Gly 
        195                 200                 205     


<210>  2
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  2

Thr Lys Lys Val Gly Ile Val Asp Thr Thr Phe Ala Arg Val Asp Met 
1               5                   10                  15      


Ala Glu Ala Ala Ile Arg Thr Leu Lys Ala Leu Ser Pro Asn Ile Lys 
            20                  25                  30          


Ile Ile Arg Lys Thr Val Pro Gly Ile Lys Asp Leu Pro Val Ala Cys 
        35                  40                  45              


Lys Lys Leu Leu Glu Glu Glu Gly Cys Asp Ile Val Met Ala Leu Gly 
    50                  55                  60                  


Met Pro Gly Lys Ala Glu Lys Asp Lys Val Cys Ala His Glu Ala Ser 
65                  70                  75                  80  


Leu Gly Leu Met Leu Ala Gln Leu Met Thr Asn Lys His Ile Ile Glu 
                85                  90                  95      


Val Phe Val His Glu Asp Glu Ala Lys Asp Asp Asp Glu Leu Asp Ile 
            100                 105                 110         


Leu Ala Leu Val Arg Ala Ile Glu His Ala Ala Asn Val Tyr Tyr Leu 
        115                 120                 125             


Leu Phe Lys Pro Glu Tyr Leu Thr Arg Met Ala Gly Lys Gly Leu Arg 
    130                 135                 140                 


Gln Gly Arg Glu Asp Ala Gly Pro Ala Arg Glu 
145                 150                 155 


<210>  3
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  3

Thr Lys Lys Val Gly Ile Val Asp Thr Thr Phe Ala Arg Val Asp Met 
1               5                   10                  15      


Ala Ser Ala Ala Ile Leu Thr Leu Lys Met Glu Ser Pro Asn Ile Lys 
            20                  25                  30          


Ile Ile Arg Lys Thr Val Pro Gly Ile Lys Asp Leu Pro Val Ala Cys 
        35                  40                  45              


Lys Lys Leu Leu Glu Glu Glu Gly Cys Asp Ile Val Met Ala Leu Gly 
    50                  55                  60                  


Met Pro Gly Lys Ala Glu Lys Asp Lys Val Cys Ala His Glu Ala Ser 
65                  70                  75                  80  


Leu Gly Leu Met Leu Ala Gln Leu Met Thr Asn Lys His Ile Ile Glu 
                85                  90                  95      


Val Phe Val His Glu Asp Glu Ala Lys Asp Asp Ala Glu Leu Lys Ile 
            100                 105                 110         


Leu Ala Ala Arg Arg Ala Ile Glu His Ala Leu Asn Val Tyr Tyr Leu 
        115                 120                 125             


Leu Phe Lys Pro Glu Tyr Leu Thr Arg Met Ala Gly Lys Gly Leu Arg 
    130                 135                 140                 


Gln Gly Phe Glu Asp Ala Gly Pro Ala Arg Glu 
145                 150                 155 


<210>  4
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  4

Ser Thr Ile Asn Asn Gln Leu Lys Ala Leu Lys Val Ile Pro Val Ile 
1               5                   10                  15      


Ala Ile Asp Asn Ala Glu Asp Ile Ile Pro Leu Gly Lys Val Leu Ala 
            20                  25                  30          


Glu Asn Gly Leu Pro Ala Ala Glu Ile Thr Phe Arg Ser Ser Ala Ala 
        35                  40                  45              


Val Lys Ala Ile Met Leu Leu Arg Ser Ala Gln Pro Glu Met Leu Ile 
    50                  55                  60                  


Gly Ala Gly Thr Ile Leu Asn Gly Val Gln Ala Leu Ala Ala Lys Glu 
65                  70                  75                  80  


Ala Gly Ala Thr Phe Val Val Ser Pro Gly Phe Asn Pro Asn Thr Val 
                85                  90                  95      


Arg Ala Cys Gln Ile Ile Gly Ile Asp Ile Val Pro Gly Val Asn Asn 
            100                 105                 110         


Pro Ser Thr Val Glu Ala Ala Leu Glu Met Gly Leu Thr Thr Leu Lys 
        115                 120                 125             


Phe Phe Pro Ala Glu Ala Ser Gly Gly Ile Ser Met Val Lys Ser Leu 
    130                 135                 140                 


Val Gly Pro Tyr Gly Asp Ile Arg Leu Met Pro Thr Gly Gly Ile Thr 
145                 150                 155                 160 


Pro Ser Asn Ile Asp Asn Tyr Leu Ala Ile Pro Gln Val Leu Ala Cys 
                165                 170                 175     


Gly Gly Thr Trp Met Val Asp Lys Lys Leu Val Thr Asn Gly Glu Trp 
            180                 185                 190         


Asp Glu Ile Ala Arg Leu Thr Arg Glu Ile Val Glu Gln Val Asn Pro 
        195                 200                 205             


<210>  5
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  5

Pro Ile Phe Thr Leu Asn Thr Asn Ile Lys Ala Thr Asp Val Pro Ser 
1               5                   10                  15      


Asp Phe Leu Ser Leu Thr Ser Arg Leu Val Gly Leu Ile Leu Ser Lys 
            20                  25                  30          


Pro Gly Ser Tyr Val Ala Val His Ile Asn Thr Asp Gln Gln Leu Ser 
        35                  40                  45              


Phe Gly Gly Ser Thr Asn Pro Ala Ala Phe Gly Thr Leu Met Ser Ile 
    50                  55                  60                  


Gly Gly Ile Glu Pro Ser Lys Asn Arg Asp His Ser Ala Val Leu Phe 
65                  70                  75                  80  


Asp His Leu Asn Ala Met Leu Gly Ile Pro Lys Asn Arg Met Tyr Ile 
                85                  90                  95      


His Phe Val Asn Leu Asn Gly Asp Asp Val Gly Trp Asn Gly Thr Thr 
            100                 105                 110         


Phe 
    


<210>  6
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  6

Asn Gln His Ser His Lys Asp Tyr Glu Thr Val Arg Ile Ala Val Val 
1               5                   10                  15      


Arg Ala Arg Trp His Ala Asp Ile Val Asp Ala Cys Val Glu Ala Phe 
            20                  25                  30          


Glu Ile Ala Met Ala Ala Ile Gly Gly Asp Arg Phe Ala Val Asp Val 
        35                  40                  45              


Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr Leu 
    50                  55                  60                  


Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val Val 
65                  70                  75                  80  


Asn Gly Gly Ile Tyr Arg His Glu Phe Val Ala Ser Ala Val Ile Asp 
                85                  90                  95      


Gly Met Met Asn Val Gln Leu Ser Thr Gly Val Pro Val Leu Ser Ala 
            100                 105                 110         


Val Leu Thr Pro His Arg Tyr Arg Asp Ser Ala Glu His His Arg Phe 
        115                 120                 125             


Phe Ala Ala His Phe Ala Val Lys Gly Val Glu Ala Ala Arg Ala Cys 
    130                 135                 140                 


Ile Glu Ile Leu Ala Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155     


<210>  7
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  7

Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
1               5                   10                  15      


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
            20                  25                  30          


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
        35                  40                  45              


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
    50                  55                  60                  


Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser 
65                  70                  75                  80  


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
                85                  90                  95      


Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
            100                 105                 110         


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
        115                 120                 125             


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
    130                 135                 140                 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
145                 150                 155                 160 


Asn Val Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
                165                 170                 175     


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
            180                 185                 190         


Ala Phe Val Glu Lys Ile Arg Gly Cys Thr Glu 
        195                 200             


<210>  8
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  8

Asn Gln His Ser His Lys Asp Tyr Glu Thr Val Arg Ile Ala Val Val 
1               5                   10                  15      


Arg Ala Arg Trp His Ala Glu Ile Val Asp Ala Cys Val Ser Ala Phe 
            20                  25                  30          


Glu Ala Ala Met Ala Asp Ile Gly Gly Asp Arg Phe Ala Val Asp Val 
        35                  40                  45              


Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr Leu 
    50                  55                  60                  


Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val Val 
65                  70                  75                  80  


Asn Gly Gly Ile Tyr Arg His Glu Phe Val Ala Ser Ala Val Ile Asp 
                85                  90                  95      


Gly Met Met Asn Val Gln Leu Ser Thr Gly Val Pro Val Leu Ser Ala 
            100                 105                 110         


Val Leu Thr Pro His Arg Tyr Arg Asp Ser Asp Ala His Thr Leu Leu 
        115                 120                 125             


Phe Leu Ala Leu Phe Ala Val Lys Gly Met Glu Ala Ala Arg Ala Cys 
    130                 135                 140                 


Val Glu Ile Leu Ala Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155     


<210>  9
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  9

Phe Thr Lys Ser Gly Asp Asp Gly Asn Thr Asn Val Ile Asn Lys Arg 
1               5                   10                  15      


Val Gly Lys Asp Ser Pro Leu Val Asn Phe Leu Gly Asp Leu Asp Glu 
            20                  25                  30          


Leu Asn Ser Phe Ile Gly Phe Ala Ile Ser Lys Ile Pro Trp Glu Asp 
        35                  40                  45              


Met Lys Lys Asp Leu Glu Arg Val Gln Val Glu Leu Phe Glu Ile Gly 
    50                  55                  60                  


Glu Asp Leu Ser Thr Gln Ser Ser Lys Lys Lys Ile Asp Glu Ser Tyr 
65                  70                  75                  80  


Val Leu Trp Leu Leu Ala Ala Thr Ala Ile Tyr Arg Ile Glu Ser Gly 
                85                  90                  95      


Pro Val Lys Leu Phe Val Ile Pro Gly Gly Ser Glu Glu Ala Ser Val 
            100                 105                 110         


Leu His Val Thr Arg Ser Val Ala Arg Arg Val Glu Arg Asn Ala Val 
        115                 120                 125             


Lys Tyr Thr Lys Glu Leu Pro Glu Ile Asn Arg Met Ile Ile Val Tyr 
    130                 135                 140                 


Leu Asn Arg Leu Ser Ser Leu Leu Phe Ala Met Ala Leu Val Ala Asn 
145                 150                 155                 160 


Lys Arg Arg Asn Gln Ser Glu Lys Ile Tyr Glu Ile Gly Lys Ser Trp 
                165                 170                 175     


<210>  10
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  10

Asn Gln His Ser His Lys Asp Tyr Glu Thr Val Arg Ile Ala Val Val 
1               5                   10                  15      


Arg Ala Arg Trp His Ala Asp Ile Val Asp Gln Cys Val Arg Ala Phe 
            20                  25                  30          


Glu Glu Ala Met Ala Asp Ala Gly Gly Asp Arg Phe Ala Val Asp Val 
        35                  40                  45              


Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr Leu 
    50                  55                  60                  


Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val Val 
65                  70                  75                  80  


Asn Gly Gly Ile Tyr Arg His Glu Phe Val Ala Ser Ala Val Ile Asp 
                85                  90                  95      


Gly Met Met Asn Val Gln Leu Ser Thr Gly Val Pro Val Leu Ser Ala 
            100                 105                 110         


Val Leu Thr Pro His Arg Tyr Arg Ser Ser Arg Glu His His Glu Phe 
        115                 120                 125             


Phe Arg Glu His Phe Met Val Lys Gly Val Glu Ala Ala Ala Ala Cys 
    130                 135                 140                 


Ile Thr Ile Leu Ala Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155     


<210>  11
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  11

Gly His Thr Lys Gly Pro Thr Pro Gln Gln His Asp Gly Ser Ala Leu 
1               5                   10                  15      


Arg Ile Gly Ile Val His Ala Arg Trp Asn Lys Thr Ile Ile Met Pro 
            20                  25                  30          


Leu Leu Ile Gly Thr Ile Ala Lys Leu Leu Glu Cys Gly Val Lys Ala 
        35                  40                  45              


Ser Asn Ile Val Val Gln Ser Val Pro Gly Ser Trp Glu Leu Pro Ile 
    50                  55                  60                  


Ala Val Gln Arg Leu Tyr Ser Ala Ser Gln Leu Gln Thr Pro Ser Ser 
65                  70                  75                  80  


Gly Pro Ser Leu Ser Ala Gly Asp Leu Leu Gly Ser Ser Thr Thr Asp 
                85                  90                  95      


Leu Thr Ala Leu Pro Thr Thr Thr Ala Ser Ser Thr Gly Pro Phe Asp 
            100                 105                 110         


Ala Leu Ile Ala Ile Gly Val Leu Ile Lys Gly Glu Thr Met His Phe 
        115                 120                 125             


Glu Tyr Ile Ala Asp Ser Val Ser His Gly Leu Met Arg Val Gln Leu 
    130                 135                 140                 


Asp Thr Gly Val Pro Val Ile Phe Gly Val Leu Thr Val Leu Thr Asp 
145                 150                 155                 160 


Asp Gln Ala Lys Ala Arg Ala Gly Val Ile Glu Gly Ser His Asn His 
                165                 170                 175     


Gly Glu Asp Trp Gly Leu Ala Ala Val Glu Met Gly Val Arg Arg Arg 
            180                 185                 190         


Asp Trp Ala Ala Gly Lys Thr Glu 
        195                 200 


<210>  12
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  12

Tyr Glu Val Asp His Ala Asp Val Tyr Asp Leu Phe Tyr Leu Gly Arg 
1               5                   10                  15      


Gly Lys Asp Tyr Ala Ala Glu Ala Ser Asp Ile Ala Asp Leu Val Arg 
            20                  25                  30          


Ser Arg Thr Pro Glu Ala Ser Ser Leu Leu Asp Val Ala Cys Gly Thr 
        35                  40                  45              


Gly Thr His Leu Glu His Phe Thr Lys Glu Phe Gly Asp Thr Ala Gly 
    50                  55                  60                  


Leu Glu Leu Ser Glu Asp Met Leu Thr His Ala Arg Lys Arg Leu Pro 
65                  70                  75                  80  


Asp Ala Thr Leu His Gln Gly Asp Met Arg Asp Phe Gln Leu Gly Arg 
                85                  90                  95      


Lys Phe Ser Ala Val Val Ser Met Phe Ser Ser Val Gly Tyr Leu Lys 
            100                 105                 110         


Thr Val Ala Glu Leu Gly Ala Ala Val Ala Ser Phe Ala Glu His Leu 
        115                 120                 125             


Glu Pro Gly Gly Val Val Val Val Glu Pro Trp Trp Phe Pro Glu Thr 
    130                 135                 140                 


Phe Ala Asp Gly Trp Val Ser Ala Asp Val Val Arg Arg Asp Gly Arg 
145                 150                 155                 160 


Thr Val Ala Arg Val Ser His Ser Val Arg Glu Gly Asn Ala Thr Arg 
                165                 170                 175     


Met Glu Val His Phe Thr Val Ala Asp Pro Gly Lys Gly Val Arg His 
            180                 185                 190         


Phe Ser Asp Val His Leu Ile Thr Leu Phe His Gln Arg Glu Tyr Glu 
        195                 200                 205             


Ala Ala Phe Met Ala Ala Gly Leu Arg Val Glu Tyr Leu Glu Gly Gly 
    210                 215                 220                 


Pro Ser Gly Arg Gly Leu Phe Val Gly Val Pro Ala 
225                 230                 235     


<210>  13
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  13

Gly Met Lys Glu Lys Phe Val Leu Ile Ile Thr His Gly Asp Phe Gly 
1               5                   10                  15      


Lys Gly Leu Leu Ser Gly Ala Glu Val Ile Ile Gly Lys Gln Glu Asn 
            20                  25                  30          


Val His Thr Val Gly Leu Asn Leu Gly Asp Asn Ile Glu Lys Val Ala 
        35                  40                  45              


Lys Glu Val Met Arg Ile Ile Ile Ala Lys Leu Ala Glu Asp Lys Glu 
    50                  55                  60                  


Ile Ile Ile Val Val Asp Leu Phe Gly Gly Ser Pro Phe Asn Ile Ala 
65                  70                  75                  80  


Leu Glu Met Met Lys Thr Phe Asp Val Lys Val Ile Thr Gly Ile Asn 
                85                  90                  95      


Met Pro Met Leu Val Glu Leu Leu Thr Ser Ile Asn Val Tyr Asp Thr 
            100                 105                 110         


Thr Glu Leu Leu Glu Asn Ile Ser Lys Ile Gly Lys Asp Gly Ile Lys 
        115                 120                 125             


Val Ile Glu Lys Ser Ser Leu Lys Met 
    130                 135         


<210>  14
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  14

Lys Tyr Asp Gly Ser Lys Leu Arg Ile Gly Ile Leu His Ala Arg Trp 
1               5                   10                  15      


Asn Leu Glu Ile Ile Ala Ala Leu Val Ala Gly Ala Ile Lys Arg Leu 
            20                  25                  30          


Gln Glu Phe Gly Val Lys Ala Glu Asn Ile Ile Ile Glu Thr Val Pro 
        35                  40                  45              


Gly Ser Phe Glu Leu Pro Tyr Gly Ser Lys Leu Phe Val Glu Lys Gln 
    50                  55                  60                  


Lys Arg Leu Gly Lys Pro Leu Asp Ala Ile Ile Pro Ile Gly Val Leu 
65                  70                  75                  80  


Ile Lys Gly Ser Thr Met His Phe Glu Tyr Ile Cys Asp Ser Thr Thr 
                85                  90                  95      


His Gln Leu Met Lys Leu Asn Phe Glu Leu Gly Ile Pro Val Ile Phe 
            100                 105                 110         


Gly Val Leu Thr Cys Leu Thr Asp Glu Gln Ala Glu Ala Arg Ala Gly 
        115                 120                 125             


Leu Ile Glu Gly Lys Met His Asn His Gly Glu Asp Trp Gly Ala Ala 
    130                 135                 140                 


Ala Val Glu Met Ala Thr Lys Phe Asn 
145                 150             


<210>  15
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  15

Ala Val Lys Gly Leu Gly Glu Val Asp Gln Lys Tyr Asp Gly Ser Lys 
1               5                   10                  15      


Leu Arg Ile Gly Ile Leu His Ala Arg Trp Asn Arg Lys Ile Ile Leu 
            20                  25                  30          


Ala Leu Val Ala Gly Ala Val Leu Arg Leu Leu Glu Phe Gly Val Lys 
        35                  40                  45              


Ala Glu Asn Ile Ile Ile Glu Thr Val Pro Gly Ser Phe Glu Leu Pro 
    50                  55                  60                  


Tyr Gly Ser Lys Leu Phe Val Glu Lys Gln Lys Arg Leu Gly Lys Pro 
65                  70                  75                  80  


Leu Asp Ala Ile Ile Pro Ile Gly Val Leu Ile Lys Gly Ser Thr Met 
                85                  90                  95      


His Phe Glu Tyr Ile Cys Asp Ser Thr Thr His Gln Leu Met Lys Leu 
            100                 105                 110         


Asn Phe Glu Leu Gly Ile Pro Val Ile Phe Gly Val Leu Thr Cys Leu 
        115                 120                 125             


Thr Asp Glu Gln Ala Glu Ala Arg Ala Gly Leu Ile Glu Gly Lys Met 
    130                 135                 140                 


His Asn His Gly Glu Asp Trp Gly Ala Ala Ala Val Glu Met Ala Thr 
145                 150                 155                 160 


Lys Phe Asn 
            


<210>  16
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  16

Gly Ala Asn Trp Tyr Leu Asp Asn Glu Ser Ser Arg Leu Ser Phe Thr 
1               5                   10                  15      


Ser Thr Lys Asn Ala Asp Ile Ala Glu Val His Arg Phe Leu Val Leu 
            20                  25                  30          


His Gly Lys Val Asp Pro Lys Gly Leu Ala Glu Val Glu Val Glu Thr 
        35                  40                  45              


Glu Ser Ile Ser Thr Gly Ile Pro Leu Arg Asp Met Leu Leu Arg Val 
    50                  55                  60                  


Leu Val Phe Gln Val Ser Lys Phe Pro Val Ala Gln Ile Asn Ala Gln 
65                  70                  75                  80  


Leu Asp Met Arg Pro Ile Asn Asn Leu Ala Pro Gly Ala Gln Leu Glu 
                85                  90                  95      


Leu Arg Leu Pro Leu Thr Val Ser Leu Arg Gly Lys Ser His Ser Tyr 
            100                 105                 110         


Asn Ala Glu Leu Leu Ala Thr Arg Leu Asp Glu Arg Arg Phe Gln Val 
        115                 120                 125             


Val Thr Leu Glu Pro Leu Val Ile His Ala Gln Asp Phe Asp Met Val 
    130                 135                 140                 


Arg Ala Phe Asn Ala Leu Arg Leu Val Ala Gly Leu Ser Ala Val Ser 
145                 150                 155                 160 


Leu Ser Val Pro Val Gly Ala Val Leu Ile Phe Thr Ala Arg 
                165                 170                 


<210>  17
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  17

Thr Asp Tyr Ile Arg Asp Gly Ser Ala Ile Lys Ala Leu Ser Phe Ala 
1               5                   10                  15      


Ile Ile Leu Ala Glu Ala Asp Leu Arg His Ile Pro Gln Asp Leu Gln 
            20                  25                  30          


Arg Leu Ala Val Arg Val Ile His Ala Cys Gly Met Val Asp Val Ala 
        35                  40                  45              


Asn Asp Leu Ala Phe Ser Glu Gly Ala Gly Lys Ala Gly Arg Asn Ala 
    50                  55                  60                  


Leu Leu Ala Gly Ala Pro Ile Leu Cys Asp Ala Arg Met Val Ala Glu 
65                  70                  75                  80  


Gly Ile Thr Arg Ser Arg Leu Pro Ala Asp Asn Arg Val Ile Tyr Thr 
                85                  90                  95      


Leu Ser Asp Pro Ser Val Pro Glu Leu Ala Lys Lys Ile Gly Asn Thr 
            100                 105                 110         


Arg Ser Ala Ala Ala Leu Asp Leu Trp Leu Pro His Ile Glu Gly Ser 
        115                 120                 125             


Ile Val Ala Ile Gly Asn Ala Pro Thr Ala Leu Phe Arg Leu Phe Glu 
    130                 135                 140                 


Leu Leu Asp Ala Gly Ala Pro Lys Pro Ala Leu Ile Ile Gly Met Pro 
145                 150                 155                 160 


Val Gly Phe Val Gly Ala Ala Glu Ser Lys Asp Glu Leu Ala Ala Asn 
                165                 170                 175     


Ser Arg Gly Val Pro Tyr Val Ile Val Arg Gly Arg Arg Gly Gly Ser 
            180                 185                 190         


Ala Met Thr Ala Ala Ala Val Asn Ala Leu Ala Ser Glu Arg Glu 
        195                 200                 205         


<210>  18
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  18

Ile Thr Val Phe Gly Leu Lys Ser Lys Leu Ala Pro Arg Arg Glu Lys 
1               5                   10                  15      


Leu Ala Glu Val Ile Tyr Ser Ser Leu His Leu Gly Leu Asp Ile Pro 
            20                  25                  30          


Lys Gly Lys His Ala Ile Arg Phe Leu Cys Leu Glu Lys Glu Asp Phe 
        35                  40                  45              


Tyr Tyr Pro Phe Asp Arg Ser Asp Asp Tyr Thr Val Ile Glu Ile Asn 
    50                  55                  60                  


Leu Met Ala Gly Arg Ser Glu Glu Thr Lys Met Leu Leu Ile Phe Leu 
65                  70                  75                  80  


Leu Phe Ile Ala Leu Glu Arg Lys Leu Gly Ile Arg Ala His Asp Val 
                85                  90                  95      


Glu Ile Thr Ile Lys Glu Gln Pro Ala His Cys Trp Gly Phe Arg Gly 
            100                 105                 110         


Arg Thr Gly Asp Ser Ala Arg Asp Leu Asp Tyr Asp Ile Tyr Val 
        115                 120                 125         


<210>  19
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  19

Gly Ser Asp Leu Gln Lys Leu Gln Arg Phe Ser Thr Cys Asp Ile Ser 
1               5                   10                  15      


Asp Gly Leu Leu Asn Val Tyr Asn Ile Pro Thr Gly Gly Tyr Phe Pro 
            20                  25                  30          


Asn Leu Thr Ala Ile Ser Pro Pro Gln Asn Ser Ser Ile Val Gly Thr 
        35                  40                  45              


Ala Tyr Thr Val Leu Phe Ala Pro Ile Asp Asp Pro Arg Pro Ala Val 
    50                  55                  60                  


Asn Tyr Ile Asp Ser Val Pro Pro Asn Ser Ile Leu Val Leu Ala Leu 
65                  70                  75                  80  


Glu Pro His Leu Gln Ser Gln Phe His Pro Phe Ile Lys Ile Thr Gln 
                85                  90                  95      


Ala Met Tyr Gly Gly Leu Met Ser Thr Arg Ala Gln Tyr Leu Lys Ser 
            100                 105                 110         


Asn Gly Thr Val Val Phe Gly Arg Ile Arg Asp Val Asp Glu His Arg 
        115                 120                 125             


Thr Leu Asn His Pro Val Phe Ala Tyr Gly Val Gly Ser Cys Ala Pro 
    130                 135                 140                 


Lys Ala Val Val Lys Ala Val Gly Thr Asn Val Gln Leu Lys Ile Leu 
145                 150                 155                 160 


Thr Ser Asp Gly Val Thr Gln Thr Ile Cys Pro Gly Asp Tyr Ile Ala 
                165                 170                 175     


Gly Asp Asn Asn Gly Ile Val Arg Ile Pro Val Gln Glu Thr Asp Ile 
            180                 185                 190         


Ser Lys Leu Val Thr Tyr Ile Glu Lys Ser Ile Glu Val Asp Arg Leu 
        195                 200                 205             


Val Ser Glu Ala Ile Lys Asn Gly Leu Pro Ala Lys Ala Ala Gln Thr 
    210                 215                 220                 


Ala Arg Arg Met Val Leu Lys Asp Tyr Ile 
225                 230                 


<210>  20
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  20

Ser Gly Met Arg Val Tyr Leu Gly Ala Asp His Ala Gly Tyr Glu Leu 
1               5                   10                  15      


Lys Gln Ala Ile Ile Ala Phe Leu Lys Met Thr Gly His Glu Pro Ile 
            20                  25                  30          


Asp Cys Gly Ala Leu Arg Tyr Asp Ala Asp Asp Asp Tyr Pro Ala Phe 
        35                  40                  45              


Cys Ile Ala Ala Ala Thr Arg Thr Val Ala Asp Pro Gly Ser Leu Gly 
    50                  55                  60                  


Ile Val Leu Gly Gly Ser Gly Asn Gly Glu Gln Ile Ala Ala Asn Lys 
65                  70                  75                  80  


Val Pro Gly Ala Arg Cys Ala Leu Ala Trp Ser Val Gln Thr Ala Ala 
                85                  90                  95      


Leu Ala Arg Glu His Asn Asn Ala Gln Leu Ile Gly Ile Gly Gly Arg 
            100                 105                 110         


Met His Thr Leu Glu Glu Ala Leu Arg Ile Val Lys Ala Phe Val Thr 
        115                 120                 125             


Thr Pro Trp Ser Lys Ala Gln Arg His Gln Arg Arg Ile Asp Ile Leu 
    130                 135                 140                 


Ala Glu Tyr Glu Arg Thr His Glu Ala Pro Pro Val Pro Gly Ala Pro 
145                 150                 155                 160 


Ala 
    


<210>  21
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  21

Gly Asp Asp Ala Arg Ile Ala Ala Ile Gly Asp Val Asp Glu Leu Asn 
1               5                   10                  15      


Ser Gln Ile Gly Val Leu Leu Ala Glu Pro Leu Pro Asp Asp Val Arg 
            20                  25                  30          


Ala Ala Leu Ser Ala Ile Gln His Asp Leu Phe Asp Leu Gly Gly Glu 
        35                  40                  45              


Leu Cys Ile Pro Gly His Ala Ala Ile Thr Glu Asp His Leu Leu Arg 
    50                  55                  60                  


Leu Ala Leu Trp Leu Val His Tyr Asn Gly Gln Leu Pro Pro Leu Glu 
65                  70                  75                  80  


Glu Phe Ile Leu Pro Gly Gly Ala Arg Gly Ala Ala Leu Ala His Val 
                85                  90                  95      


Cys Arg Thr Val Cys Arg Arg Ala Glu Arg Ser Ile Lys Ala Leu Gly 
            100                 105                 110         


Ala Ser Glu Pro Leu Asn Ile Ala Pro Ala Ala Tyr Val Asn Leu Leu 
        115                 120                 125             


Ser Asp Leu Leu Phe Val Leu Ala Arg Val Leu Asn Arg Ala Ala Gly 
    130                 135                 140                 


Gly Ala Asp Val Leu Trp Asp Arg Thr Arg Ala His 
145                 150                 155     


<210>  22
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  22

Ile Leu Ser Ala Glu Gln Ser Phe Thr Leu Arg His Pro His Gly Gln 
1               5                   10                  15      


Ala Ala Ala Leu Ala Phe Val Arg Glu Pro Ala Ala Ala Leu Ala Gly 
            20                  25                  30          


Val Gln Arg Leu Arg Gly Leu Asp Ser Asp Gly Glu Gln Val Trp Gly 
        35                  40                  45              


Glu Leu Leu Val Arg Val Pro Leu Leu Gly Glu Val Asp Leu Pro Phe 
    50                  55                  60                  


Arg Ser Glu Ile Val Arg Thr Pro Gln Gly Ala Glu Leu Arg Pro Leu 
65                  70                  75                  80  


Thr Leu Thr Gly Glu Arg Ala Trp Val Ala Val Ser Gly Gln Ala Thr 
                85                  90                  95      


Ala Ala Glu Gly Gly Glu Met Ala Phe Ala Phe Gln Phe Gln Ala His 
            100                 105                 110         


Leu Ala Thr Pro Glu Ala Glu Gly Glu Gly Gly Ala Ala Phe Glu Val 
        115                 120                 125             


Met Val Gln Ala Ala Ala Gly Val Thr Leu Leu Leu Val Ala Met Ala 
    130                 135                 140                 


Leu Pro Gln Gly Leu Ala Ala Gly Leu Pro Pro Ala 
145                 150                 155     


<210>  23
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  23

Thr Lys Lys Val Gly Ile Val Asp Thr Thr Phe Ala Arg Val Asp Met 
1               5                   10                  15      


Ala Ser Ala Ala Ile Leu Thr Leu Lys Met Glu Ser Pro Asn Ile Lys 
            20                  25                  30          


Ile Ile Arg Lys Thr Val Pro Gly Ile Lys Asp Leu Pro Val Ala Cys 
        35                  40                  45              


Lys Lys Leu Leu Glu Glu Glu Gly Cys Asp Ile Val Met Ala Leu Gly 
    50                  55                  60                  


Met Pro Gly Lys Lys Glu Lys Asp Lys Val Cys Ala His Glu Ala Ser 
65                  70                  75                  80  


Leu Gly Leu Met Leu Ala Gln Leu Met Thr Asn Lys His Ile Ile Glu 
                85                  90                  95      


Val Phe Val His Glu Asp Glu Ala Lys Asp Asp Ala Glu Leu Lys Ile 
            100                 105                 110         


Leu Ala Ala Arg Arg Ala Ile Glu His Ala Leu Asn Val Tyr Tyr Leu 
        115                 120                 125             


Leu Phe Lys Pro Glu Tyr Leu Thr Arg Met Ala Gly Lys Gly Leu Arg 
    130                 135                 140                 


Gln Gly Phe Glu Asp Ala Gly Pro Ala Arg Glu 
145                 150                 155 


<210>  24
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  24

Asp Asp Ile Asn Asn Gln Leu Lys Arg Leu Lys Val Ile Pro Val Ile 
1               5                   10                  15      


Ala Ile Asp Asn Ala Glu Asp Ile Ile Pro Leu Gly Lys Val Leu Ala 
            20                  25                  30          


Glu Asn Gly Leu Pro Ala Ala Glu Ile Thr Phe Arg Ser Ser Ala Ala 
        35                  40                  45              


Val Lys Ala Ile Met Leu Leu Arg Ser Ala Gln Pro Glu Met Leu Ile 
    50                  55                  60                  


Gly Ala Gly Thr Ile Leu Asn Gly Val Gln Ala Leu Ala Ala Lys Glu 
65                  70                  75                  80  


Ala Gly Ala Asp Phe Val Val Ser Pro Gly Phe Asn Pro Asn Thr Val 
                85                  90                  95      


Arg Ala Cys Gln Ile Ile Gly Ile Asp Ile Val Pro Gly Val Asn Asn 
            100                 105                 110         


Pro Ser Thr Val Glu Gln Ala Leu Glu Met Gly Leu Thr Thr Leu Lys 
        115                 120                 125             


Phe Phe Pro Ala Glu Ala Ser Gly Gly Ile Ser Met Val Lys Ser Leu 
    130                 135                 140                 


Val Gly Pro Tyr Gly Asp Ile Arg Leu Met Pro Thr Gly Gly Ile Thr 
145                 150                 155                 160 


Pro Asp Asn Ile Asp Asn Tyr Leu Ala Ile Pro Gln Val Leu Ala Cys 
                165                 170                 175     


Gly Gly Thr Trp Met Val Asp Lys Lys Leu Val Arg Asn Gly Glu Trp 
            180                 185                 190         


Asp Glu Ile Ala Arg Leu Thr Arg Glu Ile Val Glu Gln Val Asn Pro 
        195                 200                 205             


<210>  25
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  25

Pro Ile Phe Thr Leu Asn Thr Asn Ile Lys Ala Asp Asp Val Pro Ser 
1               5                   10                  15      


Asp Phe Leu Ser Leu Thr Ser Arg Leu Val Gly Leu Ile Leu Ser Lys 
            20                  25                  30          


Pro Gly Ser Tyr Val Ala Val His Ile Asn Thr Asp Gln Gln Leu Ser 
        35                  40                  45              


Phe Gly Gly Ser Thr Asn Pro Ala Ala Phe Gly Thr Leu Met Ser Ile 
    50                  55                  60                  


Gly Gly Ile Glu Pro Asp Lys Asn Arg Asp His Ser Ala Val Leu Phe 
65                  70                  75                  80  


Asp His Leu Asn Ala Met Leu Gly Ile Pro Lys Asn Arg Met Tyr Ile 
                85                  90                  95      


His Phe Val Asn Leu Asn Gly Asp Asp Val Gly Trp Asn Gly Thr Thr 
            100                 105                 110         


Phe 
    


<210>  26
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  26

Pro Ile Phe Thr Leu Asn Thr Asn Ile Lys Ala Asp Asp Val Pro Ser 
1               5                   10                  15      


Asp Phe Leu Ser Leu Thr Ser Arg Leu Val Gly Leu Ile Leu Ser Glu 
            20                  25                  30          


Pro Gly Ser Tyr Val Ala Val His Ile Asn Thr Asp Gln Gln Leu Ser 
        35                  40                  45              


Phe Gly Gly Ser Thr Asn Pro Ala Ala Phe Gly Thr Leu Met Ser Ile 
    50                  55                  60                  


Gly Gly Ile Glu Pro Asp Lys Asn Glu Asp His Ser Ala Val Leu Phe 
65                  70                  75                  80  


Asp His Leu Asn Ala Met Leu Gly Ile Pro Lys Asn Arg Met Tyr Ile 
                85                  90                  95      


His Phe Val Asp Leu Asp Gly Asp Asp Val Gly Trp Asn Gly Thr Thr 
            100                 105                 110         


Phe 
    


<210>  27
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  27

Asn Gln His Ser His Lys Asp His Glu Thr Val Arg Ile Ala Val Val 
1               5                   10                  15      


Arg Ala Arg Trp His Ala Asp Ile Val Asp Ala Cys Val Glu Ala Phe 
            20                  25                  30          


Glu Ile Ala Met Ala Ala Ile Gly Gly Asp Arg Phe Ala Val Asp Val 
        35                  40                  45              


Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr Leu 
    50                  55                  60                  


Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val Val 
65                  70                  75                  80  


Asn Gly Gly Ile Tyr Arg His Glu Phe Val Ala Ser Ala Val Ile Asp 
                85                  90                  95      


Gly Met Met Asn Val Gln Leu Asp Thr Gly Val Pro Val Leu Ser Ala 
            100                 105                 110         


Val Leu Thr Pro His Arg Tyr Arg Asp Ser Asp Glu His His Arg Phe 
        115                 120                 125             


Phe Ala Ala His Phe Ala Val Lys Gly Val Glu Ala Ala Arg Ala Cys 
    130                 135                 140                 


Ile Glu Ile Leu Asn Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155     


<210>  28
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  28

Asn Gln His Ser His Lys Asp His Glu Thr Val Arg Ile Ala Val Val 
1               5                   10                  15      


Arg Ala Arg Trp His Ala Asp Ile Val Asp Ala Cys Val Glu Ala Phe 
            20                  25                  30          


Glu Ile Ala Met Ala Ala Ile Gly Gly Asp Arg Phe Ala Val Asp Val 
        35                  40                  45              


Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr Leu 
    50                  55                  60                  


Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val Val 
65                  70                  75                  80  


Asp Gly Gly Ile Tyr Asp His Glu Phe Val Ala Ser Ala Val Ile Asp 
                85                  90                  95      


Gly Met Met Asn Val Gln Leu Asp Thr Gly Val Pro Val Leu Ser Ala 
            100                 105                 110         


Val Leu Thr Pro His Glu Tyr Glu Asp Ser Asp Glu Asp His Glu Phe 
        115                 120                 125             


Phe Ala Ala His Phe Ala Val Lys Gly Val Glu Ala Ala Arg Ala Cys 
    130                 135                 140                 


Ile Glu Ile Leu Asn Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155     


<210>  29
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  29

Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn 
1               5                   10                  15      


Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly 
            20                  25                  30          


Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val 
        35                  40                  45              


Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala 
    50                  55                  60                  


Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly 
65                  70                  75                  80  


Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe 
                85                  90                  95      


Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr 
            100                 105                 110         


Glu Leu Val Lys Ala Met Lys Leu Gly His Asp Ile Leu Lys Leu Phe 
        115                 120                 125             


Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro 
    130                 135                 140                 


Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn 
145                 150                 155                 160 


Val Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Asp 
                165                 170                 175     


Ala Leu Val Lys Gly Asp Pro Asp Glu Val Arg Glu Lys Ala Lys Lys 
            180                 185                 190         


Phe Val Glu Lys Ile Arg Gly Cys Thr Glu 
        195                 200         


<210>  30
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  30

Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn 
1               5                   10                  15      


Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly 
            20                  25                  30          


Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val 
        35                  40                  45              


Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala 
    50                  55                  60                  


Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly 
65                  70                  75                  80  


Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe 
                85                  90                  95      


Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr 
            100                 105                 110         


Glu Leu Val Lys Ala Met Lys Leu Gly His Asp Ile Leu Lys Leu Phe 
        115                 120                 125             


Pro Gly Glu Val Val Gly Pro Glu Phe Val Glu Ala Met Lys Gly Pro 
    130                 135                 140                 


Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asp Leu Asp Asp 
145                 150                 155                 160 


Val Cys Glu Trp Phe Asp Ala Gly Val Leu Ala Val Gly Val Gly Asp 
                165                 170                 175     


Ala Leu Val Glu Gly Asp Pro Asp Glu Val Arg Glu Asp Ala Lys Glu 
            180                 185                 190         


Phe Val Glu Glu Ile Arg Gly Cys Thr Glu 
        195                 200         


<210>  31
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  31

Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn 
1               5                   10                  15      


Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly 
            20                  25                  30          


Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val 
        35                  40                  45              


Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala 
    50                  55                  60                  


Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly 
65                  70                  75                  80  


Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe 
                85                  90                  95      


Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr 
            100                 105                 110         


Glu Leu Val Lys Ala Met Lys Leu Gly His Asp Ile Leu Lys Leu Phe 
        115                 120                 125             


Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro 
    130                 135                 140                 


Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn 
145                 150                 155                 160 


Val Cys Lys Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Lys 
                165                 170                 175     


Ala Leu Val Lys Gly Lys Pro Asp Glu Val Arg Glu Lys Ala Lys Lys 
            180                 185                 190         


Phe Val Lys Lys Ile Arg Gly Cys Thr Glu 
        195                 200         


<210>  32
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  32

Asn Gln His Ser His Lys Asp His Glu Thr Val Arg Ile Ala Val Val 
1               5                   10                  15      


Arg Ala Arg Trp His Ala Glu Ile Val Asp Ala Cys Val Ser Ala Phe 
            20                  25                  30          


Glu Ala Ala Met Arg Asp Ile Gly Gly Asp Arg Phe Ala Val Asp Val 
        35                  40                  45              


Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr Leu 
    50                  55                  60                  


Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val Val 
65                  70                  75                  80  


Asn Gly Gly Ile Tyr Arg His Glu Phe Val Ala Ser Ala Val Ile Asp 
                85                  90                  95      


Gly Met Met Asn Val Gln Leu Asp Thr Gly Val Pro Val Leu Ser Ala 
            100                 105                 110         


Val Leu Thr Pro His Arg Tyr Arg Asp Ser Asp Ala His Thr Leu Leu 
        115                 120                 125             


Phe Leu Ala Leu Phe Ala Val Lys Gly Met Glu Ala Ala Arg Ala Cys 
    130                 135                 140                 


Val Glu Ile Leu Ala Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155     


<210>  33
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  33

Asn Gln His Ser His Lys Asp His Glu Thr Val Arg Ile Ala Val Val 
1               5                   10                  15      


Arg Ala Arg Trp His Ala Glu Ile Val Asp Ala Cys Val Ser Ala Phe 
            20                  25                  30          


Glu Ala Ala Met Arg Asp Ile Gly Gly Asp Arg Phe Ala Val Asp Val 
        35                  40                  45              


Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr Leu 
    50                  55                  60                  


Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val Val 
65                  70                  75                  80  


Asp Gly Gly Ile Tyr Asp His Glu Phe Val Ala Ser Ala Val Ile Asp 
                85                  90                  95      


Gly Met Met Asn Val Gln Leu Asp Thr Gly Val Pro Val Leu Ser Ala 
            100                 105                 110         


Val Leu Thr Pro His Glu Tyr Glu Asp Ser Asp Ala Asp Thr Leu Leu 
        115                 120                 125             


Phe Leu Ala Leu Phe Ala Val Lys Gly Met Glu Ala Ala Arg Ala Cys 
    130                 135                 140                 


Val Glu Ile Leu Ala Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155     


<210>  34
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  34

Asn Gln His Ser His Lys Asp His Glu Thr Val Arg Ile Ala Val Val 
1               5                   10                  15      


Arg Ala Arg Trp His Ala Glu Ile Val Asp Ala Cys Val Ser Ala Phe 
            20                  25                  30          


Glu Ala Ala Met Arg Asp Ile Gly Gly Asp Arg Phe Ala Val Asp Val 
        35                  40                  45              


Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr Leu 
    50                  55                  60                  


Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val Val 
65                  70                  75                  80  


Asn Gly Gly Ile Tyr Arg His Glu Phe Val Ala Ser Ala Val Ile Asn 
                85                  90                  95      


Gly Met Met Asn Val Gln Leu Asn Thr Gly Val Pro Val Leu Ser Ala 
            100                 105                 110         


Val Leu Thr Pro His Asn Tyr Asp Lys Ser Lys Ala His Thr Leu Leu 
        115                 120                 125             


Phe Leu Ala Leu Phe Ala Val Lys Gly Met Glu Ala Ala Arg Ala Cys 
    130                 135                 140                 


Val Glu Ile Leu Ala Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155     


<210>  35
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>
<221>  SITE
<222>  (69)..(69)
<223>  Xaa is Ala or Lys

<400>  35

Thr Lys Lys Val Gly Ile Val Asp Thr Thr Phe Ala Arg Val Asp Met 
1               5                   10                  15      


Ala Ser Ala Ala Ile Leu Thr Leu Lys Met Glu Ser Pro Asn Ile Lys 
            20                  25                  30          


Ile Ile Arg Lys Thr Val Pro Gly Ile Lys Asp Leu Pro Val Ala Cys 
        35                  40                  45              


Lys Lys Leu Leu Glu Glu Glu Gly Cys Asp Ile Val Met Ala Leu Gly 
    50                  55                  60                  


Met Pro Gly Lys Xaa Glu Lys Asp Lys Val Cys Ala His Glu Ala Ser 
65                  70                  75                  80  


Leu Gly Leu Met Leu Ala Gln Leu Met Thr Asn Lys His Ile Ile Glu 
                85                  90                  95      


Val Phe Val His Glu Asp Glu Ala Lys Asp Asp Ala Glu Leu Lys Ile 
            100                 105                 110         


Leu Ala Ala Arg Arg Ala Ile Glu His Ala Leu Asn Val Tyr Tyr Leu 
        115                 120                 125             


Leu Phe Lys Pro Glu Tyr Leu Thr Arg Met Ala Gly Lys Gly Leu Arg 
    130                 135                 140                 


Gln Gly Phe Glu Asp Ala Gly Pro Ala Arg Glu 
145                 150                 155 


<210>  36
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Xaa is Ser or Asp

<220>
<221>  SITE
<222>  (2)..(2)
<223>  Xaa is Thr or Asp

<220>
<221>  SITE
<222>  (9)..(9)
<223>  Xaa is Ala or Arg

<220>
<221>  SITE
<222>  (84)..(84)
<223>  Xaa is Thr or Asp

<220>
<221>  SITE
<222>  (118)..(118)
<223>  Xaa is Ala or Gln

<220>
<221>  SITE
<222>  (162)..(162)
<223>  Xaa is Ser or Asp

<220>
<221>  SITE
<222>  (188)..(188)
<223>  Xaa is Thr or Arg

<400>  36

Xaa Xaa Ile Asn Asn Gln Leu Lys Xaa Leu Lys Val Ile Pro Val Ile 
1               5                   10                  15      


Ala Ile Asp Asn Ala Glu Asp Ile Ile Pro Leu Gly Lys Val Leu Ala 
            20                  25                  30          


Glu Asn Gly Leu Pro Ala Ala Glu Ile Thr Phe Arg Ser Ser Ala Ala 
        35                  40                  45              


Val Lys Ala Ile Met Leu Leu Arg Ser Ala Gln Pro Glu Met Leu Ile 
    50                  55                  60                  


Gly Ala Gly Thr Ile Leu Asn Gly Val Gln Ala Leu Ala Ala Lys Glu 
65                  70                  75                  80  


Ala Gly Ala Xaa Phe Val Val Ser Pro Gly Phe Asn Pro Asn Thr Val 
                85                  90                  95      


Arg Ala Cys Gln Ile Ile Gly Ile Asp Ile Val Pro Gly Val Asn Asn 
            100                 105                 110         


Pro Ser Thr Val Glu Xaa Ala Leu Glu Met Gly Leu Thr Thr Leu Lys 
        115                 120                 125             


Phe Phe Pro Ala Glu Ala Ser Gly Gly Ile Ser Met Val Lys Ser Leu 
    130                 135                 140                 


Val Gly Pro Tyr Gly Asp Ile Arg Leu Met Pro Thr Gly Gly Ile Thr 
145                 150                 155                 160 


Pro Xaa Asn Ile Asp Asn Tyr Leu Ala Ile Pro Gln Val Leu Ala Cys 
                165                 170                 175     


Gly Gly Thr Trp Met Val Asp Lys Lys Leu Val Xaa Asn Gly Glu Trp 
            180                 185                 190         


Asp Glu Ile Ala Arg Leu Thr Arg Glu Ile Val Glu Gln Val Asn Pro 
        195                 200                 205             


<210>  37
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>
<221>  SITE
<222>  (12)..(12)
<223>  Xaa is Thr or Asp

<220>
<221>  SITE
<222>  (32)..(32)
<223>  Xaa is Lys or Glu

<220>
<221>  SITE
<222>  (70)..(70)
<223>  Xaa is Ser or Asp

<220>
<221>  SITE
<222>  (73)..(73)
<223>  Xaa is Arg or Glu

<220>
<221>  SITE
<222>  (100)..(100)
<223>  Xaa is Asn or Asp

<220>
<221>  SITE
<222>  (102)..(102)
<223>  Xaa is Asn or Asp

<400>  37

Pro Ile Phe Thr Leu Asn Thr Asn Ile Lys Ala Xaa Asp Val Pro Ser 
1               5                   10                  15      


Asp Phe Leu Ser Leu Thr Ser Arg Leu Val Gly Leu Ile Leu Ser Xaa 
            20                  25                  30          


Pro Gly Ser Tyr Val Ala Val His Ile Asn Thr Asp Gln Gln Leu Ser 
        35                  40                  45              


Phe Gly Gly Ser Thr Asn Pro Ala Ala Phe Gly Thr Leu Met Ser Ile 
    50                  55                  60                  


Gly Gly Ile Glu Pro Xaa Lys Asn Xaa Asp His Ser Ala Val Leu Phe 
65                  70                  75                  80  


Asp His Leu Asn Ala Met Leu Gly Ile Pro Lys Asn Arg Met Tyr Ile 
                85                  90                  95      


His Phe Val Xaa Leu Xaa Gly Asp Asp Val Gly Trp Asn Gly Thr Thr 
            100                 105                 110         


Phe 
    


<210>  38
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>
<221>  SITE
<222>  (8)..(8)
<223>  Xaa is Tyr or His

<220>
<221>  SITE
<222>  (81)..(81)
<223>  Xaa is Asn or Asp

<220>
<221>  SITE
<222>  (86)..(86)
<223>  Xaa is Arg or Asp

<220>
<221>  SITE
<222>  (104)..(104)
<223>  Xaa is Ser or Asp

<220>
<221>  SITE
<222>  (118)..(118)
<223>  Xaa is Arg or Glu

<220>
<221>  SITE
<222>  (120)..(120)
<223>  Xaa is Arg or Glu

<220>
<221>  SITE
<222>  (123)..(123)
<223>  Xaa is Ala or Asp

<220>
<221>  SITE
<222>  (125)..(125)
<223>  Xaa is His or Asp

<220>
<221>  SITE
<222>  (127)..(127)
<223>  Xaa is Arg or Glu

<220>
<221>  SITE
<222>  (149)..(149)
<223>  Xaa is Ala or Asn

<400>  38

Asn Gln His Ser His Lys Asp Xaa Glu Thr Val Arg Ile Ala Val Val 
1               5                   10                  15      


Arg Ala Arg Trp His Ala Asp Ile Val Asp Ala Cys Val Glu Ala Phe 
            20                  25                  30          


Glu Ile Ala Met Ala Ala Ile Gly Gly Asp Arg Phe Ala Val Asp Val 
        35                  40                  45              


Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr Leu 
    50                  55                  60                  


Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val Val 
65                  70                  75                  80  


Xaa Gly Gly Ile Tyr Xaa His Glu Phe Val Ala Ser Ala Val Ile Asp 
                85                  90                  95      


Gly Met Met Asn Val Gln Leu Xaa Thr Gly Val Pro Val Leu Ser Ala 
            100                 105                 110         


Val Leu Thr Pro His Xaa Tyr Xaa Asp Ser Xaa Glu Xaa His Xaa Phe 
        115                 120                 125             


Phe Ala Ala His Phe Ala Val Lys Gly Val Glu Ala Ala Arg Ala Cys 
    130                 135                 140                 


Ile Glu Ile Leu Xaa Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155     


<210>  39
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>
<221>  SITE
<222>  (123)..(123)
<223>  Xaa is Thr or Asp

<220>
<221>  SITE
<222>  (136)..(136)
<223>  Xaa is Gln or Glu

<220>
<221>  SITE
<222>  (139)..(139)
<223>  Xaa is Lys or Glu

<220>
<221>  SITE
<222>  (157)..(157)
<223>  Xaa is Asn or Asp

<220>
<221>  SITE
<222>  (160)..(160)
<223>  Xaa is Asn or Asp

<220>
<221>  SITE
<222>  (163)..(163)
<223>  Xaa is Glu or Lys

<220>
<221>  SITE
<222>  (166)..(166)
<223>  Xaa is Lys or Asp

<220>
<221>  SITE
<222>  (176)..(176)
<223>  Xaa is Ser, Lys or Asp

<220>
<221>  SITE
<222>  (180)..(180)
<223>  Xaa is Lys or Glu

<220>
<221>  SITE
<222>  (182)..(182)
<223>  Xaa is Thr, Asp or Lys

<220>
<221>  SITE
<222>  (189)..(189)
<223>  Xaa is Lys or Asp

<220>
<221>  SITE
<222>  (192)..(192)
<223>  Xaa is Ala, Glu or Lys

<220>
<221>  SITE
<222>  (195)..(195)
<223>  Xaa is Glu or Lys

<220>
<221>  SITE
<222>  (196)..(196)
<223>  Xaa is Lys or Glu

<400>  39

Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn 
1               5                   10                  15      


Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly 
            20                  25                  30          


Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val 
        35                  40                  45              


Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala 
    50                  55                  60                  


Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly 
65                  70                  75                  80  


Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe 
                85                  90                  95      


Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr 
            100                 105                 110         


Glu Leu Val Lys Ala Met Lys Leu Gly His Xaa Ile Leu Lys Leu Phe 
        115                 120                 125             


Pro Gly Glu Val Val Gly Pro Xaa Phe Val Xaa Ala Met Lys Gly Pro 
    130                 135                 140                 


Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Xaa Leu Asp Xaa 
145                 150                 155                 160 


Val Cys Xaa Trp Phe Xaa Ala Gly Val Leu Ala Val Gly Val Gly Xaa 
                165                 170                 175     


Ala Leu Val Xaa Gly Xaa Pro Asp Glu Val Arg Glu Xaa Ala Lys Xaa 
            180                 185                 190         


Phe Val Xaa Xaa Ile Arg Gly Cys Thr Glu 
        195                 200         


<210>  40
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>
<221>  SITE
<222>  (8)..(8)
<223>  Xaa is Tyr or His

<220>
<221>  SITE
<222>  (37)..(37)
<223>  Xaa is Ala or Arg

<220>
<221>  SITE
<222>  (81)..(81)
<223>  Xaa is Asn or Asp

<220>
<221>  SITE
<222>  (86)..(86)
<223>  Xaa is Arg or Asp

<220>
<221>  SITE
<222>  (96)..(96)
<223>  Xaa is Asp or Asn

<220>
<221>  SITE
<222>  (104)..(104)
<223>  Xaa is Ser, Asp or Asn

<220>
<221>  SITE
<222>  (118)..(118)
<223>  Xaa is Arg, Glu or Asn

<220>
<221>  SITE
<222>  (120)..(121)
<223>  Xaa is Arg, Asp or Glu

<220>
<221>  SITE
<222>  (120)..(121)
<223>  Xaa is Asp or Lys

<220>
<221>  SITE
<222>  (123)..(123)
<223>  Xaa is Asp or Lys

<220>
<221>  SITE
<222>  (125)..(125)
<223>  Xaa is His or Asp

<400>  40

Asn Gln His Ser His Lys Asp Xaa Glu Thr Val Arg Ile Ala Val Val 
1               5                   10                  15      


Arg Ala Arg Trp His Ala Glu Ile Val Asp Ala Cys Val Ser Ala Phe 
            20                  25                  30          


Glu Ala Ala Met Xaa Asp Ile Gly Gly Asp Arg Phe Ala Val Asp Val 
        35                  40                  45              


Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr Leu 
    50                  55                  60                  


Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val Val 
65                  70                  75                  80  


Xaa Gly Gly Ile Tyr Xaa His Glu Phe Val Ala Ser Ala Val Ile Xaa 
                85                  90                  95      


Gly Met Met Asn Val Gln Leu Xaa Thr Gly Val Pro Val Leu Ser Ala 
            100                 105                 110         


Val Leu Thr Pro His Xaa Tyr Xaa Xaa Ser Xaa Ala Xaa Thr Leu Leu 
        115                 120                 125             


Phe Leu Ala Leu Phe Ala Val Lys Gly Met Glu Ala Ala Arg Ala Cys 
    130                 135                 140                 


Val Glu Ile Leu Ala Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155     


<210>  41
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  41

Gly Glu Val Pro Ile Gly Asp Pro Lys Glu Leu Asn Gly Met Glu Ile 
1               5                   10                  15      


Ala Ala Val Tyr Leu Gln Pro Ile Glu Met Glu Pro Arg Gly Ile Asp 
            20                  25                  30          


Leu Ala Ala Ser Leu Ala Asp Ile His Leu Glu Ala Asp Ile His Ala 
        35                  40                  45              


Leu Lys Asn Asn Pro Asn Gly Phe Pro Glu Gly Phe Trp Met Pro Tyr 
    50                  55                  60                  


Leu Thr Ile Ala Tyr Ala Leu Ala Asn Ala Asp Thr Gly Ala Ile Lys 
65                  70                  75                  80  


Thr Gly Thr Leu Met Pro Met Val Ala Asp Asp Gly Pro His Tyr Gly 
                85                  90                  95      


Ala Asn Ile Ala Met Glu Lys Asp Lys Lys Gly Gly Phe Gly Val Gly 
            100                 105                 110         


Thr Tyr Ala Leu Thr Phe Leu Ile Ser Asn Pro Glu Lys Gln Gly Phe 
        115                 120                 125             


Gly Arg His Val Asp Glu Glu Thr Gly Val Gly Lys Trp Phe Glu Pro 
    130                 135                 140                 


Phe Val Val Thr Tyr Phe Phe Lys Tyr Thr Gly Thr Pro Lys 
145                 150                 155             


<210>  42
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  42

Ser Gln Ala Ile Gly Ile Leu Glu Leu Thr Ser Ile Ala Lys Gly Met 
1               5                   10                  15      


Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu Val 
            20                  25                  30          


Ser Lys Thr Ile Ser Pro Gly Lys Phe Leu Leu Met Leu Gly Gly Asp 
        35                  40                  45              


Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala Gly 
    50                  55                  60                  


Glu Met Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser Val 
65                  70                  75                  80  


Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala Val 
                85                  90                  95      


Gly Ile Val Glu Thr Trp Ser Val Ala Ala Cys Ile Ser Ala Ala Asp 
            100                 105                 110         


Leu Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met Ala 
        115                 120                 125             


Phe Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val Leu 
    130                 135                 140                 


Asp Val Ala Ala Ala Val Ala Thr Ala Ser Leu Ala Ala Gly Ala Lys 
145                 150                 155                 160 


Gly Leu Leu Val Tyr Ala Ser Ile Ile Pro Arg Pro His Glu Ala Met 
                165                 170                 175     


Trp Arg Gln Met Val Glu Gly 
            180             


<210>  43
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  43

Glu Glu Val Val Leu Ile Thr Val Pro Ser Ala Leu Val Ala Val Lys 
1               5                   10                  15      


Ile Ala His Ala Leu Val Glu Glu Arg Leu Ala Ala Cys Val Asn Ile 
            20                  25                  30          


Val Pro Gly Leu Thr Ser Ile Tyr Arg Trp Gln Gly Ser Val Val Ser 
        35                  40                  45              


Asp His Glu Leu Leu Leu Leu Val Lys Thr Thr Thr His Ala Phe Pro 
    50                  55                  60                  


Lys Leu Lys Glu Arg Val Lys Ala Leu His Pro Tyr Thr Val Pro Glu 
65                  70                  75                  80  


Ile Val Ala Leu Pro Ile Ala Glu Gly Asn Arg Glu Tyr Leu Asp Trp 
                85                  90                  95      


Leu Arg Glu Asn Thr Gly 
            100         


<210>  44
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  44

Val Arg Gly Ile Arg Gly Ala Ile Thr Val Glu Glu Asp Thr Pro Ala 
1               5                   10                  15      


Ala Ile Leu Ala Ala Thr Ile Glu Leu Leu Leu Lys Met Leu Glu Ala 
            20                  25                  30          


Asn Gly Ile Gln Ser Tyr Glu Glu Leu Ala Ala Val Ile Phe Thr Val 
        35                  40                  45              


Thr Glu Asp Leu Thr Ser Ala Phe Pro Ala Glu Ala Ala Arg Leu Ile 
    50                  55                  60                  


Gly Met His Arg Val Pro Leu Leu Ser Ala Arg Glu Val Pro Val Pro 
65                  70                  75                  80  


Gly Ser Leu Pro Arg Val Ile Arg Val Leu Ala Leu Trp Asn Thr Asp 
                85                  90                  95      


Thr Pro Gln Asp Arg Val Arg His Val Tyr Leu Asn Glu Ala Val Arg 
            100                 105                 110         


Leu Arg Pro Asp Leu Glu Ser Ala Gln 
        115                 120     


<210>  45
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  45

Ser Lys Ala Lys Ile Gly Ile Val Thr Val Ser Asp Arg Ala Ser Ala 
1               5                   10                  15      


Gly Ile Thr Ala Asp Ile Ser Gly Lys Ala Ile Ile Leu Ala Leu Asn 
            20                  25                  30          


Leu Tyr Leu Thr Ser Glu Trp Glu Pro Ile Tyr Gln Val Ile Pro Asp 
        35                  40                  45              


Glu Gln Asp Val Ile Glu Thr Thr Leu Ile Lys Met Ala Asp Glu Gln 
    50                  55                  60                  


Asp Cys Cys Leu Ile Val Thr Thr Gly Gly Thr Gly Pro Ala Lys Arg 
65                  70                  75                  80  


Asp Val Thr Pro Glu Ala Thr Glu Ala Val Cys Asp Arg Met Met Pro 
                85                  90                  95      


Gly Phe Gly Glu Leu Met Arg Ala Glu Ser Leu Lys Glu Val Pro Thr 
            100                 105                 110         


Ala Ile Leu Ser Arg Gln Thr Ala Gly Leu Arg Gly Asp Ser Leu Ile 
        115                 120                 125             


Val Asn Leu Pro Gly Asp Pro Ala Ser Ile Ser Asp Cys Leu Leu Ala 
    130                 135                 140                 


Val Phe Pro Ala Ile Pro Tyr Cys Ile Asp Leu Met Glu Gly Pro Tyr 
145                 150                 155                 160 


Leu Glu Cys Asn Glu Ala Met Ile Lys Pro Phe Arg Pro Lys Ala Lys 
                165                 170                 175     


<210>  46
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  46

Val Arg Gly Ile Arg Gly Ala Ile Thr Val Asn Ser Asp Thr Pro Thr 
1               5                   10                  15      


Ser Ile Ile Ile Ala Thr Ile Leu Leu Leu Glu Lys Met Leu Glu Ala 
            20                  25                  30          


Asn Gly Ile Gln Ser Tyr Glu Glu Leu Ala Ala Val Ile Phe Thr Val 
        35                  40                  45              


Thr Glu Asp Leu Thr Ser Ala Phe Pro Ala Glu Ala Ala Arg Gln Ile 
    50                  55                  60                  


Gly Met His Arg Val Pro Leu Leu Ser Ala Arg Glu Val Pro Val Pro 
65                  70                  75                  80  


Gly Ser Leu Pro Arg Val Ile Arg Val Leu Ala Leu Trp Asn Thr Asp 
                85                  90                  95      


Thr Pro Gln Asp Arg Val Arg His Val Tyr Leu Ser Glu Ala Val Arg 
            100                 105                 110         


Leu Arg Pro Asp Leu Glu Ser Ala Gln 
        115                 120     


<210>  47
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  47

Arg Ile Thr Thr Lys Val Gly Asp Lys Gly Ser Thr Arg Leu Phe Gly 
1               5                   10                  15      


Gly Glu Glu Val Trp Lys Asp Ser Pro Ile Ile Glu Ala Asn Gly Thr 
            20                  25                  30          


Leu Asp Glu Leu Thr Ser Phe Ile Gly Glu Ala Lys His Tyr Val Asp 
        35                  40                  45              


Glu Glu Met Lys Gly Ile Leu Glu Glu Ile Gln Asn Asp Ile Tyr Lys 
    50                  55                  60                  


Ile Met Gly Glu Ile Gly Ser Lys Gly Lys Ile Glu Gly Ile Ser Glu 
65                  70                  75                  80  


Glu Arg Ile Ala Trp Leu Leu Lys Leu Ile Leu Arg Tyr Met Glu Met 
                85                  90                  95      


Val Asn Leu Lys Ser Phe Val Leu Pro Gly Gly Thr Leu Glu Ser Ala 
            100                 105                 110         


Lys Leu Asp Val Cys Arg Thr Ile Ala Arg Arg Ala Leu Arg Lys Val 
        115                 120                 125             


Leu Thr Val Thr Arg Glu Phe Gly Ile Gly Ala Glu Ala Ala Ala Tyr 
    130                 135                 140                 


Leu Leu Ala Leu Ser Asp Leu Leu Phe Leu Leu Ala Arg Val Ile Glu 
145                 150                 155                 160 


Ile Glu Lys Asn Lys Leu Lys Glu Val Arg Ser 
                165                 170     


<210>  48
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  48

Pro His Leu Val Ile Glu Ala Thr Ala Asn Leu Arg Leu Glu Thr Ser 
1               5                   10                  15      


Pro Gly Glu Leu Leu Glu Gln Ala Asn Lys Ala Leu Phe Ala Ser Gly 
            20                  25                  30          


Gln Phe Gly Glu Ala Asp Ile Lys Ser Arg Phe Val Thr Leu Glu Ala 
        35                  40                  45              


Tyr Arg Gln Gly Thr Ala Ala Val Glu Arg Ala Tyr Leu His Ala Cys 
    50                  55                  60                  


Leu Ser Ile Leu Asp Gly Arg Asp Ile Ala Thr Arg Thr Leu Leu Gly 
65                  70                  75                  80  


Ala Ser Leu Cys Ala Val Leu Ala Glu Ala Val Ala Gly Gly Gly Glu 
                85                  90                  95      


Glu Gly Val Gln Val Ser Val Glu Val Arg Glu Met Glu Arg Leu Ser 
            100                 105                 110         


Tyr Ala Lys Arg Val Val Ala Arg Gln Arg 
        115                 120         


<210>  49
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  49

Glu Ser Val Asn Thr Ser Phe Leu Ser Pro Ser Leu Val Thr Ile Arg 
1               5                   10                  15      


Asp Phe Asp Asn Gly Gln Phe Ala Val Leu Arg Ile Gly Arg Thr Gly 
            20                  25                  30          


Phe Pro Ala Asp Lys Gly Asp Ile Asp Leu Cys Leu Asp Lys Met Ile 
        35                  40                  45              


Gly Val Arg Ala Ala Gln Ile Phe Leu Gly Asp Asp Thr Glu Asp Gly 
    50                  55                  60                  


Phe Lys Gly Pro His Ile Arg Ile Arg Cys Val Asp Ile Asp Asp Lys 
65                  70                  75                  80  


His Thr Tyr Asn Ala Met Val Tyr Val Asp Leu Ile Val Gly Thr Gly 
                85                  90                  95      


Ala Ser Glu Val Glu Arg Glu Thr Ala Glu Glu Glu Ala Lys Leu Ala 
            100                 105                 110         


Leu Arg Val Ala Leu Gln Val Asp Ile Ala Asp Glu His Ser Cys Val 
        115                 120                 125             


Thr Gln Phe Glu Met Lys Leu Arg Glu Glu Leu Leu Ser Ser Asp Ser 
    130                 135                 140                 


Phe His Pro Asp Lys Asp Glu Tyr Tyr Lys Asp Phe Leu 
145                 150                 155         


<210>  50
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  50

Pro Val Ile Gln Thr Phe Val Ser Thr Pro Leu Asp His His Lys Arg 
1               5                   10                  15      


Leu Leu Leu Ala Ile Ile Tyr Arg Ile Val Thr Arg Val Val Leu Gly 
            20                  25                  30          


Lys Pro Glu Asp Leu Val Met Met Thr Phe His Asp Ser Thr Pro Met 
        35                  40                  45              


His Phe Phe Gly Ser Thr Asp Pro Val Ala Cys Val Arg Val Glu Ala 
    50                  55                  60                  


Leu Gly Gly Tyr Gly Pro Ser Glu Pro Glu Lys Val Thr Ser Ile Val 
65                  70                  75                  80  


Thr Ala Ala Ile Thr Ala Val Cys Gly Ile Val Ala Asp Arg Ile Phe 
                85                  90                  95      


Val Leu Tyr Phe Ser Pro Leu His Cys Gly Trp Asn Gly Thr Asn Phe 
            100                 105                 110         


<210>  51
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  51

Glu Glu Val Val Leu Ile Thr Val Pro Ser Ala Leu Val Ala Val Lys 
1               5                   10                  15      


Ile Ala His Ala Leu Val Glu Glu Arg Leu Ala Ala Cys Val Asn Ile 
            20                  25                  30          


Val Pro Gly Leu Thr Ser Ile Tyr Arg Glu Glu Gly Ser Val Val Ser 
        35                  40                  45              


Asp His Glu Leu Leu Leu Leu Val Lys Thr Thr Thr Asp Ala Phe Pro 
    50                  55                  60                  


Lys Leu Lys Glu Arg Val Lys Glu Leu His Pro Tyr Glu Val Pro Glu 
65                  70                  75                  80  


Ile Val Ala Leu Pro Ile Ala Glu Gly Asn Arg Glu Tyr Leu Asp Trp 
                85                  90                  95      


Leu Arg Glu Asn Thr Gly 
            100         


<210>  52
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  furin cleavage sites


<220>
<221>  SITE
<222>  (2)..(3)
<223>  Xaa is any amino acid

<400>  52

Arg Xaa Xaa Arg 
1               


<210>  53
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  53

Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
1               5                   10                  15      


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
            20                  25                  30          


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
        35                  40                  45              


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
    50                  55                  60                  


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
65                  70                  75                  80  


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
                85                  90                  95      


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
            100                 105                 110         


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
        115                 120                 125             


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
    130                 135                 140                 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
145                 150                 155                 160 


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
                165                 170                 175     


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
            180                 185                 190         


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu 
        195                 200             


<210>  54
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  furin cleavage sites

<400>  54

Arg Gln Ser Arg 
1               


<210>  55
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  furin cleavage sites

<400>  55

Arg Arg Arg Arg 
1               


<210>  56
<211>  539
<212>  PRT
<213>  Human metapneumovirus

<400>  56

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Ser Met Ile Leu Val Ser Ile Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Ser 
    530                 535                 


<210>  57
<211>  472
<212>  PRT
<213>  Human metapneumovirus

<400>  57

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Lys Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Asn Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile Leu Ser Ser 
    450                 455                 460                 


Ala Glu Lys Gly Asn Thr Gly Phe 
465                 470         


<210>  58
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  58

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Phe Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile Leu 
    450                 455                 460         


<210>  59
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  59

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Phe Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala 
    450             


<210>  60
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  60

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Phe Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile Leu Ser Ser 
    450                 455                 460                 


Ala Glu Lys Gly Asn Thr 
465                 470 


<210>  61
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  61

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Phe Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala 
    450             


<210>  62
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  62

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Cys Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Cys Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg Asn Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala 
    450             


<210>  63
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  63

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Lys Thr 
    50                  55                  60                  


Cys Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Asn Ala Ile Lys Gly Cys Leu Lys Thr Thr Asn Glu Cys 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Cys Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Asp 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala 
    450             


<210>  64
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  64

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Lys Thr 
    50                  55                  60                  


Cys Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Asn Ala Ile Lys Gly Cys Leu Lys Thr Thr Asn Glu Cys 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Cys Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Asp 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Lys Ile Leu Asn Ser 
    450                 455                 460                 


Ala Glu Ser Ala Ile 
465                 


<210>  65
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  65

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Cys Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Lys Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Asn Ala Ile Lys Gly Cys Leu Lys Thr Thr Asn Glu Cys 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Ala Asp Leu Cys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Asp 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile Cys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Cys Gln Ala 
    450             


<210>  66
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  66

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Cys Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Lys Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Asn Ala Ile Lys Gly Cys Leu Lys Thr Thr Asn Glu Cys 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Ala Asp Leu Cys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Asp 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile Cys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Cys Gln Ala Leu Val Asp Gln Ser Asn Lys Ile Leu Asn Ser 
    450                 455                 460                 


Ala Glu Ser Ala Ile 
465                 


<210>  67
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  67

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Cys Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Lys Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Phe Val Leu Ala Ile Ala Leu Gly Val Ala Thr Ala Ala 
                85                  90                  95      


Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg Leu Glu Ser 
            100                 105                 110         


Glu Val Thr Ala Ile Lys Asn Cys Leu Lys Thr Thr Asn Glu Cys Val 
        115                 120                 125             


Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg Glu 
    130                 135                 140                 


Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Ser Ala Ile Asn Lys Asn 
145                 150                 155                 160 


Lys Cys Asp Ile Asp Asp Leu Cys Met Ala Val Ser Phe Ser Gln Phe 
                165                 170                 175     


Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala Gly 
            180                 185                 190         


Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu Ala 
        195                 200                 205             


Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu Met 
    210                 215                 220                 


Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu Ile 
225                 230                 235                 240 


Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile Phe 
                245                 250                 255     


Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala Pro Ser Cys 
            260                 265                 270         


Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln Gly 
        275                 280                 285             


Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu Lys 
    290                 295                 300                 


Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala Gly 
305                 310                 315                 320 


Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser Thr 
                325                 330                 335     


Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser Met 
            340                 345                 350         


Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly Val 
        355                 360                 365             


Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu Asn 
    370                 375                 380                 


Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr Ile 
385                 390                 395                 400 


Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His Val 
                405                 410                 415     


Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile Lys Phe Pro 
            420                 425                 430         


Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Asn Ile Glu 
        435                 440                 445             


Asn Ser Gln Ala 
    450         


<210>  68
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  68

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Cys Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Lys Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Phe Val Leu Ala Ile Ala Leu Gly Val Ala Thr Ala Ala 
                85                  90                  95      


Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg Leu Glu Ser 
            100                 105                 110         


Glu Val Thr Ala Ile Lys Asn Cys Leu Lys Thr Thr Asn Glu Cys Val 
        115                 120                 125             


Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg Glu 
    130                 135                 140                 


Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Ser Ala Ile Asn Lys Asn 
145                 150                 155                 160 


Lys Cys Asp Ile Asp Asp Leu Cys Met Ala Val Ser Phe Ser Gln Phe 
                165                 170                 175     


Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala Gly 
            180                 185                 190         


Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu Ala 
        195                 200                 205             


Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu Met 
    210                 215                 220                 


Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu Ile 
225                 230                 235                 240 


Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile Phe 
                245                 250                 255     


Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala Pro Ser Cys 
            260                 265                 270         


Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln Gly 
        275                 280                 285             


Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu Lys 
    290                 295                 300                 


Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala Gly 
305                 310                 315                 320 


Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser Thr 
                325                 330                 335     


Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser Met 
            340                 345                 350         


Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly Val 
        355                 360                 365             


Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu Asn 
    370                 375                 380                 


Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr Ile 
385                 390                 395                 400 


Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His Val 
                405                 410                 415     


Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile Lys Phe Pro 
            420                 425                 430         


Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Asn Ile Glu 
        435                 440                 445             


Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile Leu Ser Ser Ala 
    450                 455                 460                 


Glu Ser Ala Ile 
465             


<210>  69
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  69

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Lys Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Lys Ala Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val Cys Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Cys Gly Ile Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Asn Ala Ile Lys Gly Ala Leu Lys Thr Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala Leu Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Asp 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Cys 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Cys Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala 
    450             


<210>  70
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  70

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Lys Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Lys Ala Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val Cys Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Cys Gly Ile Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Asn Ala Ile Lys Gly Ala Leu Lys Thr Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala Leu Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Asp 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Cys 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Cys Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Lys Ile Leu Asn Ser 
    450                 455                 460                 


Ala Glu Ser Ala Ile 
465                 


<210>  71
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  71

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Cys Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Cys Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Cys Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Cys Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Asp Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala 
465                 470         


<210>  72
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  72

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Cys Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Lys Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Asn Ala Ile Lys Gly Cys Leu Lys Thr Thr Asn Glu Cys 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Ala Asp Leu Cys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Asp 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile Cys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Cys Gln Ala 
    450             


<210>  73
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  73

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Cys Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Lys Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Arg Arg Arg Phe Val Leu Ala Ile Ala Leu Gly Val Ala Thr Ala Ala 
                85                  90                  95      


Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg Leu Glu Ser 
            100                 105                 110         


Glu Val Thr Ala Ile Lys Asn Cys Leu Lys Thr Thr Asn Glu Cys Val 
        115                 120                 125             


Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg Glu 
    130                 135                 140                 


Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Ser Ala Ile Asn Lys Asn 
145                 150                 155                 160 


Lys Cys Asp Ile Asp Asp Leu Cys Met Ala Val Ser Phe Ser Gln Phe 
                165                 170                 175     


Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala Gly 
            180                 185                 190         


Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu Ala 
        195                 200                 205             


Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu Met 
    210                 215                 220                 


Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu Ile 
225                 230                 235                 240 


Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile Phe 
                245                 250                 255     


Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala Pro Ser Cys 
            260                 265                 270         


Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln Gly 
        275                 280                 285             


Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu Lys 
    290                 295                 300                 


Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala Gly 
305                 310                 315                 320 


Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser Thr 
                325                 330                 335     


Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser Met 
            340                 345                 350         


Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly Val 
        355                 360                 365             


Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu Asn 
    370                 375                 380                 


Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr Ile 
385                 390                 395                 400 


Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His Val 
                405                 410                 415     


Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile Lys Phe Pro 
            420                 425                 430         


Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Asn Ile Glu 
        435                 440                 445             


Asn Ser Gln Ala 
    450         


<210>  74
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  74

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Lys Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val Cys Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Cys Gly Ile Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Asn Ala Ile Lys Gly Ala Leu Lys Thr Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala Leu Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Asp 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Cys 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Cys Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala 
    450             


<210>  75
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  75

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val Cys Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Phe Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Cys 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala 
    450             


<210>  76
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  76

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Leu Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Phe Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala 
    450             


<210>  77
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  77

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val Cys Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Leu Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Phe Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Cys 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala 
    450             


<210>  78
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  78

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Cys Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Lys Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Asn Ala Ile Lys Gly Ala Leu Lys Thr Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Ala Asp Leu Cys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Asp 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala 
    450             


<210>  79
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  79

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Cys Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Lys Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Asn Ala Ile Lys Gly Ala Leu Lys Thr Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Ala Asp Leu Cys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Asp 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile Ala Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ala Gln Ala 
    450             


<210>  80
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  80

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Cys Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Lys Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Cys Leu Lys Thr Thr Asn Glu Cys 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Ser Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Asp Asp Leu Cys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Asn Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala 
    450             


<210>  81
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  81

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Cys Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Cys Leu Lys Lys Thr Asn Glu Cys 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Ala Asp Leu Cys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Phe Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Cys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Cys Gln Ala 
    450             


<210>  82
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  82

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Cys Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Ala Asp Leu Cys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Phe Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala 
    450             


<210>  83
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  83

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Cys Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Cys Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Lys Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Ile Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Cys Gly Arg Asn Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Cys Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala 
    450             


<210>  84
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  84

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Cys Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Cys Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Lys Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Ile Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Cys Gly Arg Asn Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Cys Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile Leu Ser Ser 
    450                 455                 460                 


Ala Glu Lys Gly Asn Thr Gly 
465                 470     


<210>  85
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  85

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Cys Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Lys Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Asn Ala Ile Lys Gly Cys Leu Lys Thr Thr Asn Glu Cys 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Ala Asp Leu Cys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Asp 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile Cys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Cys Gln Ala 
    450             


<210>  86
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  86

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Cys Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Cys Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Lys Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Ile Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Cys Gly Arg Asn Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Cys Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala 
    450             


<210>  87
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  87

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Asn Pro Arg 
65                  70                  75                  80  


Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Cys Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Cys Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Lys Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Ile Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Cys Gly Arg Asn Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Cys Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile Leu Ser Ser 
    450                 455                 460                 


Ala Glu Lys Gly Asn Thr Gly 
465                 470     


<210>  88
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  88

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Lys Thr 
    50                  55                  60                  


Cys Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Asn Ala Ile Lys Gly Cys Leu Lys Thr Thr Asn Glu Cys 
        115                 120                 125             


Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Cys Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Asp 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala 
    450             


<210>  89
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  89

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Cys Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Cys Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Lys Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Ile Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Cys Gly Arg Asn Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Cys Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala 
    450             


<210>  90
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  90

Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr Glu Gly Tyr 
1               5                   10                  15      


Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe Thr Leu Glu 
            20                  25                  30          


Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro Ser Leu Ile 
        35                  40                  45              


Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu Leu Arg Thr 
    50                  55                  60                  


Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val Ala Thr Ala 
                85                  90                  95      


Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Cys Ile Arg Leu Glu 
            100                 105                 110         


Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr Asn Glu Ala 
        115                 120                 125             


Val Ser Thr Leu Gly Cys Gly Val Arg Val Leu Ala Thr Ala Val Arg 
    130                 135                 140                 


Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala Ile Asn Lys 
145                 150                 155                 160 


Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser Phe Ser Gln 
                165                 170                 175     


Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp Asn Ala 
            180                 185                 190         


Gly Ile Thr Pro Ala Ile Ser Lys Asp Leu Met Thr Asp Ala Glu Leu 
        195                 200                 205             


Ala Arg Ala Ile Ser Asn Met Pro Thr Ser Ala Gly Gln Ile Lys Leu 
    210                 215                 220                 


Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly Ile Leu 
225                 230                 235                 240 


Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu Pro Ile 
                245                 250                 255     


Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala Ala Pro Ser 
            260                 265                 270         


Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu Asp Gln 
        275                 280                 285             


Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro Asn Glu 
    290                 295                 300                 


Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr Ala Ala 
305                 310                 315                 320 


Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn Ile Ser 
                325                 330                 335     


Thr Thr Asn Tyr Pro Cys Lys Val Ser Cys Gly Arg Asn Pro Ile Ser 
            340                 345                 350         


Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr Lys Gly 
        355                 360                 365             


Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys Gln Leu 
    370                 375                 380                 


Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr Val Thr 
385                 390                 395                 400 


Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu Gln His 
                405                 410                 415     


Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Val Lys Phe 
            420                 425                 430         


Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Cys Phe Glu Ser Ile 
        435                 440                 445             


Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile Leu Ser Ser 
    450                 455                 460                 


Ala Glu Lys Gly Asn Thr Gly 
465                 470     


<210>  91
<211>  27
<212>  PRT
<213>  Escherichia virus T4

<400>  91

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  92
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  92

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Gly Ser Glu Lys Ala 
                485                 490                 495     


Ala Lys Ala Glu Glu Ala Ala Arg Lys Met Glu Glu Leu Phe Lys Lys 
            500                 505                 510         


His Lys Ile Val Ala Val Leu Arg Ala Asn Ser Val Glu Glu Ala Ile 
        515                 520                 525             


Glu Lys Ala Val Ala Val Phe Ala Gly Gly Val His Leu Ile Glu Ile 
    530                 535                 540                 


Thr Phe Thr Val Pro Asp Ala Asp Thr Val Ile Lys Ala Leu Ser Val 
545                 550                 555                 560 


Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala Gly Thr Val Thr Ser Val 
                565                 570                 575     


Glu Gln Ala Arg Lys Ala Val Glu Ser Gly Ala Glu Phe Ile Val Ser 
            580                 585                 590         


Pro His Leu Asp Glu Glu Ile Ser Gln Phe Ala Lys Glu Lys Gly Val 
        595                 600                 605             


Phe Tyr Met Pro Gly Val Met Thr Pro Thr Glu Leu Val Lys Ala Met 
    610                 615                 620                 


Lys Leu Gly His Thr Ile Leu Lys Leu Phe Pro Gly Glu Val Val Gly 
625                 630                 635                 640 


Pro Gln Phe Val Lys Ala Met Lys Gly Pro Phe Pro Asn Val Lys Phe 
                645                 650                 655     


Val Pro Thr Gly Gly Val Asn Leu Asp Asn Val Ala Glu Trp Phe Lys 
            660                 665                 670         


Ala Gly Val Leu Ala Val Gly Val Gly Ser Ala Leu Val Lys Gly Thr 
        675                 680                 685             


Pro Asp Glu Val Arg Glu Lys Ala Lys Ala Phe Val Glu Lys Ile Arg 
    690                 695                 700                 


Gly Ala Thr Glu Leu Glu His His His His His His 
705                 710                 715     


<210>  93
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  93

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  94
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  94

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Gly Ser Gly Gly Ser Gly 
                485                 490                 495     


Ser Gly Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala 
            500                 505                 510         


Arg Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu 
        515                 520                 525             


Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe 
    530                 535                 540                 


Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala 
545                 550                 555                 560 


Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile 
                565                 570                 575     


Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val 
            580                 585                 590         


Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile 
        595                 600                 605             


Ser Gln Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met 
    610                 615                 620                 


Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu 
625                 630                 635                 640 


Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met 
                645                 650                 655     


Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn 
            660                 665                 670         


Leu Asp Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly 
        675                 680                 685             


Val Gly Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys 
    690                 695                 700                 


Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His 
705                 710                 715                 720 


His His His His His 
                725 


<210>  95
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  95

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  96
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  96

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Cys Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Cys Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg Asn 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  97
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  97

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Cys Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Cys Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Cys Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Cys Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Asp Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  98
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  98

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Cys Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Cys Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Cys Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Cys Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Asp Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Lys Ile 
465                 470                 475                 480 


Leu Asn Ser Ala Glu Ser Ala Ile Gly Ser Gly Gly Ser Gly Ser Gly 
                485                 490                 495     


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
            500                 505                 510         


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
        515                 520                 525             


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
    530                 535                 540                 


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
545                 550                 555                 560 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
                565                 570                 575     


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
            580                 585                 590         


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
        595                 600                 605             


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
    610                 615                 620                 


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
625                 630                 635                 640 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
                645                 650                 655     


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
            660                 665                 670         


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
        675                 680                 685             


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
    690                 695                 700                 


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
705                 710                 715                 720 


His His His 
            


<210>  99
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  99

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Cys Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Cys Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Cys Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Cys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Asp Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Cys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Cys Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  100
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  100

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Cys Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Cys Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Cys Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Cys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Asp Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Cys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Cys Gln Ala Leu Val Asp Gln Ser Asn Lys Ile 
465                 470                 475                 480 


Leu Asn Ser Ala Glu Ser Ala Ile Gly Ser Gly Gly Ser Gly Ser Gly 
                485                 490                 495     


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
            500                 505                 510         


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
        515                 520                 525             


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
    530                 535                 540                 


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
545                 550                 555                 560 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
                565                 570                 575     


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
            580                 585                 590         


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
        595                 600                 605             


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
    610                 615                 620                 


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
625                 630                 635                 640 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
                645                 650                 655     


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
            660                 665                 670         


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
        675                 680                 685             


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
    690                 695                 700                 


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
705                 710                 715                 720 


His His His 
            


<210>  101
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  101

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Cys Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Phe Val Leu Ala Ile Ala Leu Gly Val Ala 
            100                 105                 110         


Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg 
        115                 120                 125             


Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Cys Leu Lys Thr Thr Asn 
    130                 135                 140                 


Glu Cys Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala 
145                 150                 155                 160 


Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Ser Ala Ile 
                165                 170                 175     


Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Cys Met Ala Val Ser Phe 
            180                 185                 190         


Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp 
        195                 200                 205             


Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala 
    210                 215                 220                 


Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile 
225                 230                 235                 240 


Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly 
                245                 250                 255     


Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu 
            260                 265                 270         


Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala 
        275                 280                 285             


Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu 
    290                 295                 300                 


Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro 
305                 310                 315                 320 


Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr 
                325                 330                 335     


Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn 
            340                 345                 350         


Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro 
        355                 360                 365             


Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr 
    370                 375                 380                 


Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys 
385                 390                 395                 400 


Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr 
                405                 410                 415     


Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu 
            420                 425                 430         


Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile 
        435                 440                 445             


Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu 
    450                 455                 460                 


Asn Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met 
                485                 490                 495     


Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn 
            500                 505                 510         


Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly 
        515                 520                 525             


Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val 
    530                 535                 540                 


Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala 
545                 550                 555                 560 


Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser Gly 
                565                 570                 575     


Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe 
            580                 585                 590         


Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr 
        595                 600                 605             


Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe 
    610                 615                 620                 


Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro 
625                 630                 635                 640 


Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn 
                645                 650                 655     


Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser 
            660                 665                 670         


Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys Ala 
        675                 680                 685             


Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His His 
    690                 695                 700                 


His His 
705     


<210>  102
<211>  722
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  102

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Cys Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Phe Val Leu Ala Ile Ala Leu Gly Val Ala 
            100                 105                 110         


Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg 
        115                 120                 125             


Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Cys Leu Lys Thr Thr Asn 
    130                 135                 140                 


Glu Cys Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala 
145                 150                 155                 160 


Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Ser Ala Ile 
                165                 170                 175     


Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Cys Met Ala Val Ser Phe 
            180                 185                 190         


Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp 
        195                 200                 205             


Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala 
    210                 215                 220                 


Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile 
225                 230                 235                 240 


Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly 
                245                 250                 255     


Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu 
            260                 265                 270         


Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala 
        275                 280                 285             


Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu 
    290                 295                 300                 


Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro 
305                 310                 315                 320 


Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr 
                325                 330                 335     


Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn 
            340                 345                 350         


Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro 
        355                 360                 365             


Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr 
    370                 375                 380                 


Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys 
385                 390                 395                 400 


Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr 
                405                 410                 415     


Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu 
            420                 425                 430         


Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile 
        435                 440                 445             


Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu 
    450                 455                 460                 


Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile Leu 
465                 470                 475                 480 


Ser Ser Ala Glu Ser Ala Ile Gly Ser Gly Gly Ser Gly Ser Gly Ser 
                485                 490                 495     


Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met 
            500                 505                 510         


Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn 
        515                 520                 525             


Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly 
    530                 535                 540                 


Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val 
545                 550                 555                 560 


Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala 
                565                 570                 575     


Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser Gly 
            580                 585                 590         


Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe 
        595                 600                 605             


Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr 
    610                 615                 620                 


Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe 
625                 630                 635                 640 


Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro 
                645                 650                 655     


Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn 
            660                 665                 670         


Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser 
        675                 680                 685             


Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys Ala 
    690                 695                 700                 


Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His His 
705                 710                 715                 720 


His His 
        


<210>  103
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  103

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Lys Ala Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Cys Thr Ala Ala Ala Val Thr Cys Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Leu Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Asp Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Cys Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Cys Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  104
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  104

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Lys Ala Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Cys Thr Ala Ala Ala Val Thr Cys Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Leu Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Asp Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Cys Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Cys Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Lys Ile 
465                 470                 475                 480 


Leu Asn Ser Ala Glu Ser Ala Ile Gly Ser Gly Gly Ser Gly Ser Gly 
                485                 490                 495     


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
            500                 505                 510         


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
        515                 520                 525             


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
    530                 535                 540                 


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
545                 550                 555                 560 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
                565                 570                 575     


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
            580                 585                 590         


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
        595                 600                 605             


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
    610                 615                 620                 


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
625                 630                 635                 640 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
                645                 650                 655     


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
            660                 665                 670         


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
        675                 680                 685             


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
    690                 695                 700                 


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
705                 710                 715                 720 


His His His 
            


<210>  105
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  105

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Cys Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Cys Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Cys Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Cys Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Asp Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  106
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  106

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Cys Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Cys Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Cys Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Cys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Asp Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Cys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Cys Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  107
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  107

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Cys Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Ala Ile Ala Leu Gly Val Ala 
            100                 105                 110         


Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile Arg 
        115                 120                 125             


Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Cys Leu Lys Thr Thr Asn 
    130                 135                 140                 


Glu Cys Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr Ala 
145                 150                 155                 160 


Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Ser Ala Ile 
                165                 170                 175     


Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Cys Met Ala Val Ser Phe 
            180                 185                 190         


Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser Asp 
        195                 200                 205             


Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp Ala 
    210                 215                 220                 


Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln Ile 
225                 230                 235                 240 


Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe Gly 
                245                 250                 255     


Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln Leu 
            260                 265                 270         


Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala Ala 
        275                 280                 285             


Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg Glu 
    290                 295                 300                 


Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr Pro 
305                 310                 315                 320 


Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp Thr 
                325                 330                 335     


Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile Asn 
            340                 345                 350         


Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His Pro 
        355                 360                 365             


Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys Tyr 
    370                 375                 380                 


Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile Lys 
385                 390                 395                 400 


Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp Thr 
                405                 410                 415     


Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly Glu 
            420                 425                 430         


Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro Ile 
        435                 440                 445             


Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe Glu 
    450                 455                 460                 


Asn Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met 
                485                 490                 495     


Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn 
            500                 505                 510         


Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly 
        515                 520                 525             


Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val 
    530                 535                 540                 


Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala 
545                 550                 555                 560 


Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser Gly 
                565                 570                 575     


Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe 
            580                 585                 590         


Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr 
        595                 600                 605             


Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe 
    610                 615                 620                 


Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro 
625                 630                 635                 640 


Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn 
                645                 650                 655     


Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser 
            660                 665                 670         


Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys Ala 
        675                 680                 685             


Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His His 
    690                 695                 700                 


His His 
705     


<210>  108
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  108

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Cys Thr Ala Ala Ala Val Thr Cys Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Leu Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Asp Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Cys Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Cys Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  109
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  109

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Cys Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Cys Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  110
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  110

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Leu Asn Lys Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  111
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  111

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Cys Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Leu Asn Lys Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Cys Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  112
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  112

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Cys Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Cys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Asp Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  113
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  113

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Cys Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Cys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Asp Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Ala Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ala Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  114
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  114

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Cys Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Cys Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Cys Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Cys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  115
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  115

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Cys Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Cys Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Cys Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Cys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Cys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Cys Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  116
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  116

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Cys Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Cys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  117
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  117

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Cys Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Cys Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Lys Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Ile Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Cys Gly Arg Asn 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Cys Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  118
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  118

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Cys Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Cys Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Lys Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Ile Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Cys Gly Arg Asn 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Cys Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Gly Ser Gly Gly Ser Gly 
                485                 490                 495     


Ser Gly Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala 
            500                 505                 510         


Arg Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu 
        515                 520                 525             


Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe 
    530                 535                 540                 


Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala 
545                 550                 555                 560 


Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile 
                565                 570                 575     


Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val 
            580                 585                 590         


Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile 
        595                 600                 605             


Ser Gln Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met 
    610                 615                 620                 


Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu 
625                 630                 635                 640 


Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met 
                645                 650                 655     


Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn 
            660                 665                 670         


Leu Asp Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly 
        675                 680                 685             


Val Gly Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys 
    690                 695                 700                 


Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His 
705                 710                 715                 720 


His His His His His 
                725 


<210>  119
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  119

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Cys Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Cys Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Cys Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Cys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Asp Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Cys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Cys Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Cys Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  120
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  120

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Cys Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Cys Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Lys Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Ile Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Cys Gly Arg Asn 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Cys Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Cys Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  121
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  121

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Cys Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Cys Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Lys Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Ile Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Cys Gly Arg Asn 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Cys Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Gly Ser Gly Gly Ser Gly 
                485                 490                 495     


Ser Gly Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala 
            500                 505                 510         


Arg Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu 
        515                 520                 525             


Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe 
    530                 535                 540                 


Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala 
545                 550                 555                 560 


Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile 
                565                 570                 575     


Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val 
            580                 585                 590         


Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile 
        595                 600                 605             


Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met 
    610                 615                 620                 


Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu 
625                 630                 635                 640 


Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met 
                645                 650                 655     


Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn 
            660                 665                 670         


Leu Asp Asn Val Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly 
        675                 680                 685             


Val Gly Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys 
    690                 695                 700                 


Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Cys Thr Glu Leu Glu His 
705                 710                 715                 720 


His His His His His 
                725 


<210>  122
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  122

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Thr Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Cys Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Ile Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Asn Ala Ile Lys Gly Cys Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Cys Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Glu Phe Val Ser Lys Asn Leu Thr Ser Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Tyr Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Cys Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Ile Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Asp Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Lys Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Asp Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Arg Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Pro Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Cys Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  123
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  123

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Cys Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Cys Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Lys Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Ile Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Cys Gly Arg Asn 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Cys Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
                485                 490                 495     


Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
            500                 505                 510         


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
        515                 520                 525             


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
    530                 535                 540                 


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
545                 550                 555                 560 


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
                565                 570                 575     


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
            580                 585                 590         


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
        595                 600                 605             


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
    610                 615                 620                 


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
625                 630                 635                 640 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
                645                 650                 655     


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
            660                 665                 670         


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
        675                 680                 685             


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His His His 
    690                 695                 700                 


His His His 
705         


<210>  124
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  124

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Cys Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Cys Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Lys Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Ile Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Cys Gly Arg Asn 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Cys Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Gly Ser Gly Gly Ser Gly 
                485                 490                 495     


Ser Gly Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala 
            500                 505                 510         


Arg Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu 
        515                 520                 525             


Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe 
    530                 535                 540                 


Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala 
545                 550                 555                 560 


Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile 
                565                 570                 575     


Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val 
            580                 585                 590         


Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile 
        595                 600                 605             


Ser Gln Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met 
    610                 615                 620                 


Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu 
625                 630                 635                 640 


Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met 
                645                 650                 655     


Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn 
            660                 665                 670         


Leu Asp Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly 
        675                 680                 685             


Val Gly Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys 
    690                 695                 700                 


Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu Leu Glu His 
705                 710                 715                 720 


His His His His His 
                725 


<210>  125
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  foldon sequence

<400>  125

Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys 
1               5                   10          


<210>  126
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  126

Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Gly Ser 
1               5                   10          


<210>  127
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  127

Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
1               5                   10                  15  


<210>  128
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  128

Gly Gly Ser Gly Gly Ser Gly Ser 
1               5               


<210>  129
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  129

Gly Ser Gly Gly Ser Gly Ser Gly 
1               5               


<210>  130
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  130

Gly Ser Gly Ser Gly Ser Gly 
1               5           


<210>  131
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker sequence

<400>  131

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
1               5                   10                  15  


<210>  132
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  132

Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala 
1               5                   10                  15      


Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly 
            20                  25                  30          


Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr 
        35                  40                  45              


Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly 
    50                  55                  60                  


Ala Gly Thr Val Thr Ser Val Glu Gln Ala Arg Lys Ala Val Glu Ser 
65                  70                  75                  80  


Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln 
                85                  90                  95      


Phe Ala Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro 
            100                 105                 110         


Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu 
        115                 120                 125             


Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly 
    130                 135                 140                 


Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp 
145                 150                 155                 160 


Asn Val Ala Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly 
                165                 170                 175     


Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys 
            180                 185                 190         


Ala Phe Val Glu Lys Ile Arg Gly Ala Thr Glu 
        195                 200             


<210>  133
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  133

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu 
            


<210>  134
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  134

Met Ser Trp Lys Val Met Ile Ile Ile Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu 
            


<210>  135
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  135

Asn Leu Ala Glu Lys Met Tyr Lys Ala Gly Asn Ala Met Tyr Arg Lys 
1               5                   10                  15      


Gly Gln Tyr Thr Ile Ala Ile Ile Ala Tyr Thr Leu Ala Leu Leu Lys 
            20                  25                  30          


Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Ala Tyr 
        35                  40                  45              


Lys Lys Gly Glu Tyr Asp Glu Ala Ile Glu Ala Tyr Gln Lys Ala Leu 
    50                  55                  60                  


Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala 
65                  70                  75                  80  


Tyr Tyr Lys Gln Gly Asp Tyr Asp Glu Ala Ile Glu Tyr Tyr Lys Lys 
                85                  90                  95      


Ala Leu Arg Leu Asp Pro Arg Asn Val Asp Ala Ile Glu Asn Leu Ile 
            100                 105                 110         


Glu Ala Glu Glu Lys Gln Gly 
        115                 


<210>  136
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  136

Glu Glu Ala Glu Leu Ala Tyr Leu Leu Gly Glu Leu Ala Tyr Lys Leu 
1               5                   10                  15      


Gly Glu Tyr Arg Ile Ala Ile Arg Ala Tyr Arg Ile Ala Leu Lys Arg 
            20                  25                  30          


Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr 
        35                  40                  45              


Lys Gln Gly Asp Tyr Arg Glu Ala Ile Arg Tyr Tyr Leu Arg Ala Leu 
    50                  55                  60                  


Lys Leu Asp Pro Glu Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala 
65                  70                  75                  80  


Leu Tyr Lys Gln Gly Lys Tyr Asp Leu Ala Ile Ile Ala Tyr Gln Ala 
                85                  90                  95      


Ala Leu Glu Glu Asp Pro Asn Asn Ala Glu Ala Lys Gln Asn Leu Gly 
            100                 105                 110         


Asn Ala Lys Gln Lys Gln Gly 
        115                 


<210>  137
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  137

Asn Ser Ala Glu Ala Met Tyr Lys Met Gly Asn Ala Ala Tyr Lys Gln 
1               5                   10                  15      


Gly Asp Tyr Ile Leu Ala Ile Ile Ala Tyr Leu Leu Ala Leu Glu Lys 
            20                  25                  30          


Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Ala Tyr 
        35                  40                  45              


Lys Gln Gly Asp Tyr Asp Glu Ala Ile Glu Tyr Tyr Gln Lys Ala Leu 
    50                  55                  60                  


Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala 
65                  70                  75                  80  


Tyr Tyr Lys Gln Gly Asp Tyr Asp Glu Ala Ile Glu Tyr Tyr Glu Lys 
                85                  90                  95      


Ala Leu Glu Leu Asp Pro Asn Asn Ala Glu Ala Leu Lys Asn Leu Leu 
            100                 105                 110         


Glu Ala Ile Ala Glu Gln Asp 
        115                 


<210>  138
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  138

Thr Asp Pro Leu Ala Val Ile Leu Tyr Ile Ala Ile Leu Lys Ala Glu 
1               5                   10                  15      


Lys Ser Ile Ala Arg Ala Lys Ala Ala Glu Ala Leu Gly Lys Ile Gly 
            20                  25                  30          


Asp Glu Arg Ala Val Glu Pro Leu Ile Lys Ala Leu Lys Asp Glu Asp 
        35                  40                  45              


Ala Leu Val Arg Ala Ala Ala Ala Asp Ala Leu Gly Gln Ile Gly Asp 
    50                  55                  60                  


Glu Arg Ala Val Glu Pro Leu Ile Lys Ala Leu Lys Asp Glu Glu Gly 
65                  70                  75                  80  


Leu Val Arg Ala Ser Ala Ala Ile Ala Leu Gly Gln Ile Gly Asp Glu 
                85                  90                  95      


Arg Ala Val Gln Pro Leu Ile Lys Ala Leu Thr Asp Glu Arg Asp Leu 
            100                 105                 110         


Val Arg Val Ala Ala Ala Val Ala Leu Gly Arg Ile Gly Asp Glu Lys 
        115                 120                 125             


Ala Val Arg Pro Leu Ile Ile Val Leu Lys Asp Glu Glu Gly Glu Val 
    130                 135                 140                 


Arg Glu Ala Ala Ala Ile Ala Leu Gly Ser Ile Gly Gly Glu Arg Val 
145                 150                 155                 160 


Arg Ala Ala Met Glu Lys Leu Ala Glu Arg Gly Thr Gly Phe Ala Arg 
                165                 170                 175     


Lys Val Ala Val Asn Tyr Leu Glu Thr His Lys 
            180                 185         


<210>  139
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  139

Glu Glu Ala Glu Leu Ala Tyr Leu Leu Gly Glu Leu Ala Tyr Lys Leu 
1               5                   10                  15      


Gly Glu Tyr Arg Ile Ala Ile Arg Ala Tyr Arg Ile Ala Leu Lys Arg 
            20                  25                  30          


Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr 
        35                  40                  45              


Lys Gln Gly Asp Tyr Asp Glu Ala Ile Glu Tyr Tyr Gln Lys Ala Leu 
    50                  55                  60                  


Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala 
65                  70                  75                  80  


Tyr Tyr Lys Gln Gly Asp Tyr Asp Glu Ala Ile Glu Tyr Tyr Glu Lys 
                85                  90                  95      


Ala Leu Glu Leu Asp Pro Glu Asn Leu Glu Ala Leu Gln Asn Leu Leu 
            100                 105                 110         


Asn Ala Met Asp Lys Gln Gly 
        115                 


<210>  140
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  140

Ile Glu Glu Val Val Ala Glu Met Ile Asp Ile Leu Ala Glu Ser Ser 
1               5                   10                  15      


Lys Lys Ser Ile Glu Glu Leu Ala Arg Ala Ala Asp Asn Lys Thr Thr 
            20                  25                  30          


Glu Lys Ala Val Ala Glu Ala Ile Glu Glu Ile Ala Arg Leu Ala Thr 
        35                  40                  45              


Ala Ala Ile Gln Leu Ile Glu Ala Leu Ala Lys Asn Leu Ala Ser Glu 
    50                  55                  60                  


Glu Phe Met Ala Arg Ala Ile Ser Ala Ile Ala Glu Leu Ala Lys Lys 
65                  70                  75                  80  


Ala Ile Glu Ala Ile Tyr Arg Leu Ala Asp Asn His Thr Thr Asp Thr 
                85                  90                  95      


Phe Met Ala Arg Ala Ile Ala Ala Ile Ala Asn Leu Ala Val Thr Ala 
            100                 105                 110         


Ile Leu Ala Ile Ala Ala Leu Ala Ser Asn His Thr Thr Glu Glu Phe 
        115                 120                 125             


Met Ala Arg Ala Ile Ser Ala Ile Ala Glu Leu Ala Lys Lys Ala Ile 
    130                 135                 140                 


Glu Ala Ile Tyr Arg Leu Ala Asp Asn His Thr Thr Asp Lys Phe Met 
145                 150                 155                 160 


Ala Ala Ala Ile Glu Ala Ile Ala Leu Leu Ala Thr Leu Ala Ile Leu 
                165                 170                 175     


Ala Ile Ala Leu Leu Ala Ser Asn His Thr Thr Glu Lys Phe Met Ala 
            180                 185                 190         


Arg Ala Ile Met Ala Ile Ala Ile Leu Ala Ala Lys Ala Ile Glu Ala 
        195                 200                 205             


Ile Tyr Arg Leu Ala Asp Asn His Thr Ser Pro Thr Tyr Ile Glu Lys 
    210                 215                 220                 


Ala Ile Glu Ala Ile Glu Lys Ile Ala Arg Lys Ala Ile Lys Ala Ile 
225                 230                 235                 240 


Glu Met Leu Ala Lys Asn Ile Thr Thr Glu Glu Tyr Lys Glu Lys Ala 
                245                 250                 255     


Lys Lys Ile Ile Asp Ile Ile Arg Lys Leu Ala Lys Met Ala Ile Lys 
            260                 265                 270         


Lys Leu Glu Asp Asn Arg Thr 
        275                 


<210>  141
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  141

Lys Tyr Asp Gly Ser Lys Leu Arg Ile Gly Ile Leu His Ala Arg Trp 
1               5                   10                  15      


Asn Ala Glu Ile Ile Leu Ala Leu Val Leu Gly Ala Leu Lys Arg Leu 
            20                  25                  30          


Gln Glu Phe Gly Val Lys Arg Glu Asn Ile Ile Ile Glu Thr Val Pro 
        35                  40                  45              


Gly Ser Phe Glu Leu Pro Tyr Gly Ser Lys Leu Phe Val Glu Lys Gln 
    50                  55                  60                  


Lys Arg Leu Gly Lys Pro Leu Asp Ala Ile Ile Pro Ile Gly Val Leu 
65                  70                  75                  80  


Ile Lys Gly Ser Thr Met His Phe Glu Tyr Ile Cys Asp Ser Thr Thr 
                85                  90                  95      


His Gln Leu Met Lys Leu Asn Phe Glu Leu Gly Ile Pro Val Ile Phe 
            100                 105                 110         


Gly Val Leu Thr Cys Leu Thr Asp Glu Gln Ala Glu Ala Arg Ala Gly 
        115                 120                 125             


Leu Ile Glu Gly Lys Met His Asn His Gly Glu Asp Trp Gly Ala Ala 
    130                 135                 140                 


Ala Val Glu Met Ala Thr Lys Phe Asn 
145                 150             


<210>  142
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  142

Glu Glu Ala Glu Leu Ala Tyr Leu Leu Gly Glu Leu Ala Tyr Lys Leu 
1               5                   10                  15      


Gly Glu Tyr Arg Ile Ala Ile Arg Ala Tyr Arg Ile Ala Leu Lys Arg 
            20                  25                  30          


Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr 
        35                  40                  45              


Lys Gln Gly Arg Tyr Arg Glu Ala Ile Glu Tyr Tyr Gln Lys Ala Leu 
    50                  55                  60                  


Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala 
65                  70                  75                  80  


Tyr Tyr Glu Arg Gly Glu Tyr Glu Glu Ala Ile Glu Tyr Tyr Arg Lys 
                85                  90                  95      


Ala Leu Arg Leu Asp Pro Asn Asn Ala Asp Ala Met Gln Asn Leu Leu 
            100                 105                 110         


Asn Ala Lys Met Arg Glu Glu 
        115                 


<210>  143
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  poly-His tag

<400>  143

His His His His His His 
1               5       


