                         SEQUENCE LISTING

<110>  NYU SCHOOL OF MEDICINE
 
<120>  MACROPINOCYTOSIS SELECTIVE MONOBODY-DRUG CONJUGATES

<130>  147462.002261

<140>  PCT/US2021/058807
<141>  2021-11-10

<150>  63/112,039
<151>  2020-11-10

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  1

Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      


Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 
            20                  25                  30          


Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 
        35                  40                  45              


Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 
    50                  55                  60                  


Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp 
65                  70                  75                  80  


Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  


<210>  2
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  non-binding FN3 domain consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is selected from Asp, Ser, Ala, Glu, Gly, Lys, 
       Asn, and Gln

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is selected from Asp, Ser, Ala, Glu, Gly, Lys, 
       Asn, and Gln

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 is selected from Ser, Ala, Glu, Gly, Lys, Asn,
       Asp, and Gln

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa as position 25 is selected from Pro, Ser, Ala, Glu, Gly, Lys,
       Asn, Asp, and Gln

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa as position 26 is selected from Ala, Ser, Glu, Gly, Lys, Asn,
       Asp, and Gln

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa as position 27 is selected from Val, Ser, Ala, Glu, Gly, Lys,
       Asn, Asp, and Gln

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa as position 28 is selected from Thr, Ser, Ala, Glu, Gly, Lys,
       Asn, Asp, and Gln

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa as position 30 is selected from Arg, Ser, Ala, Glu, Gly, Lys,
       Asn, Asp, and Gln

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  Xaa as position 75 is selected from Val, Ser, Ala, Glu, Gly, Lys,
       Asn, Asp, and Gln

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Xaa as position 76 is selected from Thr, Ser, Ala, Glu, Gly, Lys,
       Asn, Asp, and Gln

<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  Xaa as position 77 is selected from Gly, Ser, Ala, Glu, Lys, Asn,
       Asp, and Gln

<220>
<221>  MISC_FEATURE
<222>  (78)..(78)
<223>  Xaa as position 78 is selected from Arg, Ser, Ala, Glu, Gly, Lys,
       Asn, Asp, and Gln

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  Xaa as position 79 is selected from Gly, Ser, Ala, Glu, Lys, Asn,
       Asp, and Gln

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  Xaa as position 80 is selected from Asp, Ser, Ala, Glu, Gly, Lys,
       Asn, and Gln

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  Xaa as position 81 is selected from Ser, Ala, Glu, Gly, Lys, Asn,
       Asp, and Gln

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  Xaa as position 82 is selected from Pro, Ser, Ala, Glu, Gly, Lys,
       Asn, Asp, and Gln

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  Xaa as position 83 is selected from Ala, Ser, Glu, Gly, Lys, Asn,
       Asp, Ala, Asn, Asp, and Gln

<400>  2

Val Ser Xaa Val Pro Thr Xaa Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      


Ser Leu Leu Ile Ser Trp Asp Xaa Xaa Xaa Xaa Xaa Val Xaa Tyr Tyr 
            20                  25                  30          


Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 
        35                  40                  45              


Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 
    50                  55                  60                  


Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  


<210>  3
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  non-binding FN3 domain

<400>  3

Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      


Ser Leu Leu Ile Ser Trp Asp Ala Ser Ser Ser Ser Val Ser Tyr Tyr 
            20                  25                  30          


Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 
        35                  40                  45              


Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 
    50                  55                  60                  


Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Ser Ser Ser Ser Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  


<210>  4
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  FG loop variant

<400>  4

Ser Ser Ser Ser Ser Ser Ser Ser Ser 
1               5                   


<210>  5
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  BC loop variant

<400>  5

Ser Ser Ser Ser Ser Val Ser 
1               5           


<210>  6
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn Ser 
1               5                   10                  15      


His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys Tyr 
            20                  25                  30          


Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu Ala 
        35                  40                  45              


Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys Pro 
    50                  55                  60                  


Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly His 
65                  70                  75                  80  


Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr 
                85                  90              


<210>  7
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  7

Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe Val 
1               5                   10                  15      


Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val Glu 
            20                  25                  30          


Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu Pro 
        35                  40                  45              


Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg Lys 
    50                  55                  60                  


Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser Leu 
65                  70                  75                  80  


Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp 
                85                  90      


<210>  8
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Pro Pro Asp Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val 
1               5                   10                  15      


Val Arg Trp Ser Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val 
            20                  25                  30          


Tyr Ser Pro Ser Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu 
        35                  40                  45              


Thr Ala Asn Ser Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr 
    50                  55                  60                  


Asn Ile Thr Ile Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val 
65                  70                  75                  80  


Val Ile Gln Gln Glu Thr Thr Gly Thr Pro Arg Ser 
                85                  90          


<210>  9
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Pro Arg Asp Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr 
1               5                   10                  15      


Ile Met Trp Thr Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp 
            20                  25                  30          


Val Ile Pro Val Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile 
        35                  40                  45              


Ser Arg Asn Thr Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr 
    50                  55                  60                  


Tyr Tyr Phe Lys Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro 
65                  70                  75                  80  


Leu Thr Ala Gln Gln Thr Thr Lys Leu Asp 
                85                  90  


<210>  10
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Pro Thr Asn Leu Gln Phe Val Asn Glu Thr Asp Ser Thr Val Leu 
1               5                   10                  15      


Val Arg Trp Thr Pro Pro Arg Ala Gln Ile Thr Gly Tyr Arg Leu Thr 
            20                  25                  30          


Val Gly Leu Thr Arg Arg Gly Gln Pro Arg Gln Tyr Asn Val Gly Pro 
        35                  40                  45              


Ser Val Ser Lys Tyr Pro Leu Arg Asn Leu Gln Pro Ala Ser Glu Tyr 
    50                  55                  60                  


Thr Val Ser Leu Val Ala Ile Lys Gly Asn Gln Glu Ser Pro Lys Ala 
65                  70                  75                  80  


Thr Gly Val Phe Thr Thr Leu Gln Pro Gly 
                85                  90  


<210>  11
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  11

Ser Ser Ile Pro Pro Tyr Asn Thr Glu Val Thr Glu Thr Thr Ile Val 
1               5                   10                  15      


Ile Thr Trp Thr Pro Ala Pro Arg Ile Gly Phe Lys Leu Gly Val Arg 
            20                  25                  30          


Pro Ser Gln Gly Gly Glu Ala Pro Arg Glu Val Thr Ser Asp Ser Gly 
        35                  40                  45              


Ser Ile Val Val Ser Gly Leu Thr Pro Gly Val Glu Tyr Val Tyr Thr 
    50                  55                  60                  


Ile Gln Val Leu Arg Asp Gly Gln Glu Arg Asp Ala Pro Ile Val Asn 
65                  70                  75                  80  


Lys Val Val Thr Pro Leu Ser 
                85          


<210>  12
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  12

Pro Pro Thr Asn Leu His Leu Glu Ala Asn Pro Asp Thr Gly Val Leu 
1               5                   10                  15      


Thr Val Ser Trp Glu Arg Ser Thr Thr Pro Asp Ile Thr Gly Tyr Arg 
            20                  25                  30          


Ile Thr Thr Thr Pro Thr Asn Gly Gln Gln Gly Asn Ser Leu Glu Glu 
        35                  40                  45              


Val Val His Ala Asp Gln Ser Ser Cys Thr Phe Asp Asn Leu Ser Pro 
    50                  55                  60                  


Gly Leu Glu Tyr Asn Val Ser Val Tyr Thr Val Lys Asp Asp Lys Glu 
65                  70                  75                  80  


Ser Val Pro Ile Ser Asp Thr Ile Ile Pro Glu Val Pro Gln Leu 
                85                  90                  95  


<210>  13
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  13

Thr Asp Leu Ser Phe Val Asp Ile Thr Asp Ser Ser Ile Gly Leu Arg 
1               5                   10                  15      


Trp Thr Pro Leu Asn Ser Ser Thr Ile Ile Gly Tyr Arg Ile Thr Val 
            20                  25                  30          


Val Ala Ala Gly Glu Gly Ile Pro Ile Phe Glu Asp Phe Val Asp Ser 
        35                  40                  45              


Ser Val Gly Tyr Tyr Thr Val Thr Gly Leu Glu Pro Gly Ile Asp Tyr 
    50                  55                  60                  


Asp Ile Ser Val Ile Thr Leu Ile Asn Gly Gly Glu Ser Ala Pro Thr 
65                  70                  75                  80  


Thr Leu Thr Gln Gln Thr Ala Val Pro 
                85                  


<210>  14
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  14

Pro Pro Thr Asp Leu Arg Phe Thr Asn Ile Gly Pro Asp Thr Met Arg 
1               5                   10                  15      


Val Thr Trp Ala Pro Pro Pro Ser Ile Asp Leu Thr Asn Phe Leu Val 
            20                  25                  30          


Arg Tyr Ser Pro Val Lys Asn Glu Glu Asp Val Ala Glu Leu Ser Ile 
        35                  40                  45              


Ser Pro Ser Asp Asn Ala Val Val Leu Thr Asn Leu Leu Pro Gly Thr 
    50                  55                  60                  


Glu Tyr Val Val Ser Val Ser Ser Val Tyr Glu Gln His Glu Ser Thr 
65                  70                  75                  80  


Pro Leu Arg Gly Arg Gln Lys Thr Gly Leu Asp Ser Pro 
                85                  90              


<210>  15
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  15

Thr Gly Ile Asp Phe Ser Asp Ile Thr Ala Asn Ser Phe Thr Val His 
1               5                   10                  15      


Trp Ile Ala Pro Arg Ala Thr Ile Thr Gly Tyr Arg Ile Arg His His 
            20                  25                  30          


Pro Glu His Phe Ser Gly Arg Pro Arg Glu Asp Arg Val Pro His Ser 
        35                  40                  45              


Arg Asn Ser Ile Thr Leu Thr Asn Leu Thr Pro Gly Thr Glu Tyr Val 
    50                  55                  60                  


Val Ser Ile Val Ala Leu Asn Gly Arg Glu Glu Ser Pro Leu Leu Ile 
65                  70                  75                  80  


Gly Gln Gln Ser Thr Val Ser Asp 
                85              


<210>  16
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  16

Lys Pro Ser Gln Met Gln Val Thr Asp Val Gln Asp Asn Ser Ile Ser 
1               5                   10                  15      


Val Lys Trp Leu Pro Ser Ser Ser Pro Val Thr Gly Tyr Arg Val Thr 
            20                  25                  30          


Thr Thr Pro Lys Asn Gly Pro Gly Pro Thr Lys Thr Lys Thr Ala Gly 
        35                  40                  45              


Pro Asp Gln Thr Glu Met Thr Ile Glu Gly Leu Gln Pro Thr Val Glu 
    50                  55                  60                  


Tyr Val Val Ser Val Tyr Ala Gln Asn Pro Ser Gly Glu Ser Gln Pro 
65                  70                  75                  80  


Leu Val Gln Thr Ala Val Thr Asn Ile Asp Arg Pro 
                85                  90          


<210>  17
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  17

Lys Gly Leu Ala Phe Thr Asp Val Asp Val Asp Ser Ile Lys Ile Ala 
1               5                   10                  15      


Trp Glu Ser Pro Gln Gly Gln Val Ser Arg Tyr Arg Val Thr Tyr Ser 
            20                  25                  30          


Ser Pro Glu Asp Gly Ile His Glu Leu Phe Pro Ala Pro Asp Gly Glu 
        35                  40                  45              


Glu Asp Thr Ala Glu Leu Gln Gly Leu Arg Pro Gly Ser Glu Tyr Thr 
    50                  55                  60                  


Val Ser Val Val Ala Leu His Asp Asp Met Glu Ser Gln Pro Leu Ile 
65                  70                  75                  80  


Gly Thr Gln Ser Thr Ala Ile Pro 
                85              


<210>  18
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Pro Thr Asp Leu Lys Phe Thr Gln Val Thr Pro Thr Ser Leu Ser 
1               5                   10                  15      


Ala Gln Trp Thr Pro Pro Asn Val Gln Leu Thr Gly Tyr Arg Val Arg 
            20                  25                  30          


Val Thr Pro Lys Glu Lys Thr Gly Pro Met Lys Glu Ile Asn Leu Ala 
        35                  40                  45              


Pro Asp Ser Ser Ser Val Val Val Ser Gly Leu Met Val Ala Thr Lys 
    50                  55                  60                  


Tyr Glu Val Ser Val Tyr Ala Leu Lys Asp Thr Leu Thr Ser Arg Pro 
65                  70                  75                  80  


Ala Gln Gly Val Val Thr Thr Leu Glu Asn Val Ser Pro Pro 
                85                  90                  


<210>  19
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  19

Arg Arg Ala Arg Val Thr Asp Ala Thr Glu Thr Thr Ile Thr Ile Ser 
1               5                   10                  15      


Trp Arg Thr Lys Thr Glu Thr Ile Thr Gly Phe Gln Val Asp Ala Val 
            20                  25                  30          


Pro Ala Asn Gly Gln Thr Pro Ile Gln Arg Thr Ile Lys Pro Asp Val 
        35                  40                  45              


Arg Ser Tyr Thr Ile Thr Gly Leu Gln Pro Gly Thr Asp Tyr Lys Ile 
    50                  55                  60                  


Tyr Leu Tyr Thr Leu Asn Asp Asn Ala Arg Ser Ser Pro Val Val Ile 
65                  70                  75                  80  


Asp Ala Ser Thr Ala Ile Asp 
                85          


<210>  20
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Pro Ser Asn Leu Arg Phe Leu Ala Thr Thr Pro Asn Ser Leu Leu 
1               5                   10                  15      


Val Ser Trp Gln Pro Pro Arg Ala Arg Ile Thr Gly Tyr Ile Ile Lys 
            20                  25                  30          


Tyr Glu Lys Pro Gly Ser Pro Pro Arg Glu Val Val Pro Arg Pro Arg 
        35                  40                  45              


Pro Gly Val Thr Glu Ala Thr Ile Thr Gly Leu Glu Pro Gly Thr Glu 
    50                  55                  60                  


Tyr Thr Ile Tyr Val Ile Ala Leu Lys Asn Asn Gln Lys Ser Glu Pro 
65                  70                  75                  80  


Leu Ile Gly Arg Lys Lys Thr Asp Glu Leu Pro 
                85                  90      


<210>  21
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  21

Pro Gly Leu Asn Pro Asn Ala Ser Thr Gly Gln Glu Ala Leu Ser Gln 
1               5                   10                  15      


Thr Thr Ile Ser Trp Ala Pro Phe Gln Asp Thr Ser Glu Tyr Ile Ile 
            20                  25                  30          


Ser Cys His Pro Val Gly Thr Asp Glu Glu Pro Leu Gln Phe Arg Val 
        35                  40                  45              


Pro Gly Thr Ser Thr Ser Ala Thr Leu Thr Gly Leu Thr Arg Gly Ala 
    50                  55                  60                  


Thr Tyr Asn Val Ile Val Glu Ala Leu Lys Asp Gln Gln Arg His Lys 
65                  70                  75                  80  


Val Arg Glu Glu Val Val Thr Val Gly Asn Ser Val Asn Glu Gly 
                85                  90                  95  


<210>  22
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  22

Pro Pro Lys Asp Leu Val Val Thr Glu Val Thr Glu Glu Thr Val Asn 
1               5                   10                  15      


Leu Ala Trp Asp Asn Glu Met Arg Val Thr Glu Tyr Leu Val Val Tyr 
            20                  25                  30          


Thr Pro Thr His Glu Gly Gly Leu Glu Met Gln Phe Arg Val Pro Gly 
        35                  40                  45              


Asp Gln Thr Ser Thr Ile Ile Gln Glu Leu Glu Pro Gly Val Glu Tyr 
    50                  55                  60                  


Phe Ile Arg Val Phe Ala Ile Leu Glu Asn Lys Lys Ser Ile Pro Val 
65                  70                  75                  80  


Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala Pro 
                85                  90      


<210>  23
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  23

Glu Gly Leu Lys Phe Lys Ser Ile Lys Glu Thr Ser Val Glu Val Glu 
1               5                   10                  15      


Trp Asp Pro Leu Asp Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe Arg 
            20                  25                  30          


Asn Met Asn Lys Glu Asp Glu Gly Glu Ile Thr Lys Ser Leu Arg Arg 
        35                  40                  45              


Pro Glu Thr Ser Tyr Arg Gln Thr Gly Leu Ala Pro Gly Gln Glu Tyr 
    50                  55                  60                  


Glu Ile Ser Leu His Ile Val Lys Asn Asn Thr Arg Gly Pro Gly Leu 
65                  70                  75                  80  


Lys Arg Val Thr Thr Thr Arg Leu Asp 
                85                  


<210>  24
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala Leu 
1               5                   10                  15      


Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly Ile Glu Leu Thr 
            20                  25                  30          


Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile Asp Leu Thr 
        35                  40                  45              


Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys Pro Asp Thr Glu 
    50                  55                  60                  


Tyr Glu Val Ser Leu Ile Ser Arg Arg Gly Asp Met Ser Ser Asn Pro 
65                  70                  75                  80  


Ala Lys Glu Thr Phe Thr Thr Gly Leu Asp 
                85                  90  


<210>  25
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  25

Ala Pro Arg Asn Leu Arg Arg Val Ser Gln Thr Asp Asn Ser Ile Thr 
1               5                   10                  15      


Leu Glu Trp Arg Asn Gly Lys Ala Ala Ile Asp Ser Tyr Arg Ile Lys 
            20                  25                  30          


Tyr Ala Pro Ile Ser Gly Gly Asp His Ala Glu Val Asp Val Pro Lys 
        35                  40                  45              


Ser Gln Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly Leu Arg Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gly Ile Gly Val Ser Ala Val Lys Glu Asp Lys Glu Ser 
65                  70                  75                  80  


Asn Pro Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp Thr Pro Lys Asp 
                85                  90                  95      


<210>  26
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  26

Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu Leu Trp Lys 
1               5                   10                  15      


Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr Ser Leu Pro 
            20                  25                  30          


Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr Thr Ser Tyr 
        35                  40                  45              


Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val Leu Leu Thr 
    50                  55                  60                  


Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val Lys Ala Ser 
65                  70                  75                  80  


Thr Glu Gln Ala Pro 
                85  


<210>  27
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  27

Glu Leu Glu Asn Leu Thr Val Thr Glu Val Gly Trp Asp Gly Leu Arg 
1               5                   10                  15      


Leu Asn Trp Thr Ala Ala Asp Gln Ala Tyr Glu His Phe Ile Ile Gln 
            20                  25                  30          


Val Gln Glu Ala Asn Lys Val Glu Ala Ala Arg Asn Leu Thr Val Pro 
        35                  40                  45              


Gly Ser Leu Arg Ala Val Asp Ile Pro Gly Leu Lys Ala Ala Thr Pro 
    50                  55                  60                  


Tyr Thr Val Ser Ile Tyr Gly Val Ile Gln Gly Tyr Arg Thr Pro Val 
65                  70                  75                  80  


Leu Ser Ala Glu Ala Ser Thr Gly Glu Thr 
                85                  90  


<210>  28
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  28

Asn Leu Gly Glu Val Val Val Ala Glu Val Gly Trp Asp Ala Leu Lys 
1               5                   10                  15      


Leu Asn Trp Thr Ala Pro Glu Gly Ala Tyr Glu Tyr Phe Phe Ile Gln 
            20                  25                  30          


Val Gln Glu Ala Asp Thr Val Glu Ala Ala Gln Asn Leu Thr Val Pro 
        35                  40                  45              


Gly Gly Leu Arg Ser Thr Asp Leu Pro Gly Leu Lys Ala Ala Thr His 
    50                  55                  60                  


Tyr Thr Ile Thr Ile Arg Gly Val Thr Gln Asp Phe Ser Thr Thr Pro 
65                  70                  75                  80  


Leu Ser Val Glu Val Leu Thr Glu Glu Val 
                85                  90  


<210>  29
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  29

Asp Met Gly Asn Leu Thr Val Thr Glu Val Ser Trp Asp Ala Leu Arg 
1               5                   10                  15      


Leu Asn Trp Thr Thr Pro Asp Gly Thr Tyr Asp Gln Phe Thr Ile Gln 
            20                  25                  30          


Val Gln Glu Ala Asp Gln Val Glu Glu Ala His Asn Leu Thr Val Pro 
        35                  40                  45              


Gly Ser Leu Arg Ser Met Glu Ile Pro Gly Leu Arg Ala Gly Thr Pro 
    50                  55                  60                  


Tyr Thr Val Thr Leu His Gly Glu Val Arg Gly His Ser Thr Arg Pro 
65                  70                  75                  80  


Leu Ala Val Glu Val Val Thr Glu Asp Leu Pro Gln Leu 
                85                  90              


<210>  30
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  30

Gly Asp Leu Ala Val Ser Glu Val Gly Trp Asp Gly Leu Arg Leu Asn 
1               5                   10                  15      


Trp Thr Ala Ala Asp Asn Ala Tyr Glu His Phe Val Ile Gln Val Gln 
            20                  25                  30          


Glu Val Asn Lys Val Glu Ala Ala Gln Asn Leu Thr Leu Pro Gly Ser 
        35                  40                  45              


Leu Arg Ala Val Asp Ile Pro Gly Leu Glu Ala Ala Thr Pro Tyr Arg 
    50                  55                  60                  


Val Ser Ile Tyr Gly Val Ile Arg Gly Tyr Arg Thr Pro Val Leu Ser 
65                  70                  75                  80  


Ala Glu Ala Ser Thr Ala Lys Glu Pro 
                85                  


<210>  31
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  31

Glu Ile Gly Asn Leu Asn Val Ser Asp Ile Thr Pro Glu Ser Phe Asn 
1               5                   10                  15      


Leu Ser Trp Met Ala Thr Asp Gly Ile Phe Glu Thr Phe Thr Ile Glu 
            20                  25                  30          


Ile Ile Asp Ser Asn Arg Leu Leu Glu Thr Val Glu Tyr Asn Ile Ser 
        35                  40                  45              


Gly Ala Glu Arg Thr Ala His Ile Ser Gly Leu Pro Pro Ser Thr Asp 
    50                  55                  60                  


Phe Ile Val Tyr Leu Ser Gly Leu Ala Pro Ser Ile Arg Thr Lys Thr 
65                  70                  75                  80  


Ile Ser Ala Thr Ala Thr Thr Glu Ala Leu Pro Leu 
                85                  90          


<210>  32
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  32

Glu Asn Leu Thr Ile Ser Asp Ile Asn Pro Tyr Gly Phe Thr Val Ser 
1               5                   10                  15      


Trp Met Ala Ser Glu Asn Ala Phe Asp Ser Phe Leu Val Thr Val Val 
            20                  25                  30          


Asp Ser Gly Lys Leu Leu Asp Pro Gln Glu Phe Thr Leu Ser Gly Thr 
        35                  40                  45              


Gln Arg Lys Leu Glu Leu Arg Gly Leu Ile Thr Gly Ile Gly Tyr Glu 
    50                  55                  60                  


Val Met Val Ser Gly Phe Thr Gln Gly His Gln Thr Lys Pro Leu Arg 
65                  70                  75                  80  


Ala Glu Ile Val Thr Glu Ala Glu Pro 
                85                  


<210>  33
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Val Asp Asn Leu Leu Val Ser Asp Ala Thr Pro Asp Gly Phe Arg 
1               5                   10                  15      


Leu Ser Trp Thr Ala Asp Glu Gly Val Phe Asp Asn Phe Val Leu Lys 
            20                  25                  30          


Ile Arg Asp Thr Lys Lys Gln Ser Glu Pro Leu Glu Ile Thr Leu Leu 
        35                  40                  45              


Ala Pro Glu Arg Thr Arg Asp Ile Thr Gly Leu Arg Glu Ala Thr Glu 
    50                  55                  60                  


Tyr Glu Ile Glu Leu Tyr Gly Ile Ser Lys Gly Arg Arg Ser Gln Thr 
65                  70                  75                  80  


Val Ser Ala Ile Ala Thr Thr Ala Met Gly 
                85                  90  


<210>  34
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  34

Ser Pro Lys Glu Val Ile Phe Ser Asp Ile Thr Glu Asn Ser Ala Thr 
1               5                   10                  15      


Val Ser Trp Arg Ala Pro Thr Ala Gln Val Glu Ser Phe Arg Ile Thr 
            20                  25                  30          


Tyr Val Pro Ile Thr Gly Gly Thr Pro Ser Met Val Thr Val Asp Gly 
        35                  40                  45              


Thr Lys Thr Gln Thr Arg Leu Val Lys Leu Ile Pro Gly Val Glu Tyr 
    50                  55                  60                  


Leu Val Ser Ile Ile Ala Met Lys Gly Phe Glu Glu Ser Glu Pro Val 
65                  70                  75                  80  


Ser Gly Ser Phe Thr Thr Ala Leu Asp Gly 
                85                  90  


<210>  35
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  35

Pro Ser Gly Leu Val Thr Ala Asn Ile Thr Asp Ser Glu Ala Leu Ala 
1               5                   10                  15      


Arg Trp Gln Pro Ala Ile Ala Thr Val Asp Ser Tyr Val Ile Ser Tyr 
            20                  25                  30          


Thr Gly Glu Lys Val Pro Glu Ile Thr Arg Thr Val Ser Gly Asn Thr 
        35                  40                  45              


Val Glu Tyr Ala Leu Thr Asp Leu Glu Pro Ala Thr Glu Tyr Thr Leu 
    50                  55                  60                  


Arg Ile Phe Ala Glu Lys Gly Pro Gln Lys Ser Ser Thr Ile Thr Ala 
65                  70                  75                  80  


Lys Phe Thr Thr Asp Leu Asp 
                85          


<210>  36
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  36

Ser Pro Arg Asp Leu Thr Ala Thr Glu Val Gln Ser Glu Thr Ala Leu 
1               5                   10                  15      


Leu Thr Trp Arg Pro Pro Arg Ala Ser Val Thr Gly Tyr Leu Leu Val 
            20                  25                  30          


Tyr Glu Ser Val Asp Gly Thr Val Lys Glu Val Ile Val Gly Pro Asp 
        35                  40                  45              


Thr Thr Ser Tyr Ser Leu Ala Asp Leu Ser Pro Ser Thr His Tyr Thr 
    50                  55                  60                  


Ala Lys Ile Gln Ala Leu Asn Gly Pro Leu Arg Ser Asn Met Ile Gln 
65                  70                  75                  80  


Thr Ile Phe Thr Thr Ile Gly Leu Leu 
                85                  


<210>  37
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  37

Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu 
1               5                   10                  15      


Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr Arg Ile Thr 
            20                  25                  30          


Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro 
        35                  40                  45              


Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp 
    50                  55                  60                  


Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp Ser Pro Ala 
65                  70                  75                  80  


Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Asp 
                85                  90                  


