
                                SEQUENCE LISTING

<110> Rivella, Stefano
      Demsko, Perry

<120> COMPOSITIONS AND METHODS FOR IN VIVO
  GENE TRANSFER

<130> 3460-P06824WO00

<140> PCT/US2021/058764
<141> 2021-11-10

<150> 63/111,899          
<151> 2020-11-10  

<160> 7

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 4777
<212> DNA
<213> Homo sapiens

<400> 1
gtttccggcc gccgtcgctg tccagggagg ctgaggcgag aggtagctgt ccgggtgggg 60
agcccgcact accttcttcc tcttcctcct cctcctccgg gtgaggggag cgaaggttgg 120
gggtccccga gcccatggac caggaggagg cggaggccgc cgagagccgg ggccccgcta 180
tgtggccctg agccccgtgt actggttctg cctgtctgga gggccatgga gaagaggctg 240
ggagtcaagc caaatcctgc ttcctggatt ttatcaggat attattggca gacatctgcg 300
aagtggttga gaagcctgta cctgttttat acttgctttt gcttcagcgt tctgtggttg 360
tcaacagatg ccagtgagag caggtgccag caggggaaga cacaatttgg agttggcctg 420
agatctgggg gagaaaatca cctctggctt cttgaaggaa ccccctctct ccagtcatgt 480
tgggctgcct gctgccagga ctctgcctgc catgtctttt ggtggctaga agggatgtgc 540
attcaggcag actgcagcag gccccagagc tgccgggctt ttaggacaca ctcctccaat 600
tccatgctgg tgtttttaaa aaaattccaa actgcagatg atttgggctt tctacctgaa 660
gatgatgtac cacatcttct ggggctaggt tggaactggg catcttggag gcagagccca 720
cccagagctg cactcagacc tgctgtatct tccagtgacc agcagagctt aatcaggaag 780
cttcagaaga gaggtagtcc cagtgacgta gttacaccta tagtgacaca gcattctaaa 840
gtgaatgact ccaacgaatt aggtggtctg actaccagtg gctctgcaga ggtccacaag 900
gcgattacaa tttccagtcc cctaaccaca gacctgactg cagagctgtc tggtgggcca 960
aagaatgtat cagtgcaacc tgaaatatca gagggtcttg ctactacgcc cagcactcaa 1020
caagtaaaaa gttctgagaa aacccagatt gctgtccccc agccagtggc tccctcctac 1080
agttatgcta cccctacccc ccaggcctct ttccagagca cctcagcacc atacccagtt 1140
ataaaggaac tggtggtatc tgctggagag agtgtccaga taaccctgcc taagaatgaa 1200
gttcaattaa atgcatatgt tctccaagaa ccacctaaag gagaaaccta cacctacgac 1260
tggcagctga ttactcatcc tagagactac agtggagaaa tggaagggaa acattcccag 1320
atcctcaaac tatcgaagct cactccaggc ctgtatgaat tcaaagtgat tgtagagggt 1380
caaaatgccc atggggaagg ctatgtgaac gtgacagtca agccagagcc ccgtaagaat 1440
cggcccccca ttgctattgt gtcacctcag ttccaggaga tctctttgcc aaccacttct 1500
acagtcattg atggcagtca aagcactgat gatgataaaa tcgttcagta ccattgggaa 1560
gaacttaagg ggcctctaag agaagagaag atttctgaag atacagccat attaaaacta 1620
agtaaactcg tccctgggaa ctacactttc agcttgactg tagtagactc tgatggagct 1680
accaactcta ctactgcaaa cctgacagtg aacaaagctg tggattaccc ccctgtggcc 1740
aacgcaggcc ccaaccaagt gatcaccctg ccccaaaact ccatcaccct ctttgggaac 1800
cagagcactg atgatcatgg catcaccagc tatgagtggt cactcagccc aagcagcaaa 1860
gggaaagtgg tggagatgca gggtgttaga acaccaacct tacagctctc tgcgatgcaa 1920
gaaggagact acacttacca gctcacagtg actgacacaa taggacagca ggccactgct 1980
caagtgactg ttattgtgca acctgaaaac aataagcctc ctcaggcaga tgcaggccca 2040
gataaagagc tgacccttcc tgtggatagc acaaccctgg atggcagcaa gagctcagat 2100
gatcagaaaa ttatctcata tctctgggaa aaaacacagg gacctgatgg ggtgcagctc 2160
gagaatgcta acagcagtgt tgctactgtg actgggctgc aagtggggac ctatgtgttc 2220
accttgactg tcaaagatga gaggaacctg caaagccaga gctctgtgaa tgtcattgtc 2280
aaagaagaaa taaacaaacc acctatagcc aagataactg ggaatgtggt gattacccta 2340
cccacgagca cagcagagct ggatggctct aagtcctcag atgacaaggg aatagtcagc 2400
tacctctgga ctcgagatga ggggagccca gcagcagggg aggtgttaaa tcactctgac 2460
catcacccta tcctttttct ttcaaacctg gttgagggaa cctacacttt tcacctgaaa 2520
gtgaccgatg caaagggtga gagtgacaca gaccggacca ctgtggaggt gaaacctgat 2580
cccaggaaaa acaacctggt ggagatcatc ttggatatca acgtcagtca gctaactgag 2640
aggctgaagg ggatgttcat ccgccagatt ggggtcctcc tgggggtgct ggattccgac 2700
atcattgtgc aaaagattca gccgtacacg gagcagagca ccaaaatggt attttttgtt 2760
caaaacgagc ctccccacca gatcttcaaa ggccatgagg tggcagcgat gctcaagagt 2820
gagctgcgga agcaaaaggc agactttttg atattcagag ccttggaagt caacactgtc 2880
acatgtcagc tgaactgttc cgaccatggc cactgtgact cgttcaccaa acgctgtatc 2940
tgtgaccctt tttggatgga gaatttcatc aaggtgcagc tgagggatgg agacagcaac 3000
tgtgagtgga gcgtgttata tgttatcatt gctacctttg tcattgttgt tgccttggga 3060
atcctgtctt ggactgtgat ctgttgttgt aagaggcaaa aaggaaaacc caagaggaaa 3120
agcaagtaca agatcctgga tgccacggat caggaaagcc tggagctgaa gccaacctcc 3180
cgagcaggca tcaaacagaa aggccttttg ctaagtagca gcctgatgca ctccgagtca 3240
gagctggaca gcgatgatgc catctttaca tggccagacc gagagaaggg caaactcctg 3300
catggtcaga atggctctgt acccaacggg cagacccctc tgaaggccag gagcccgcgg 3360
gaggagatcc tgtagccacc tggtctgtct cctcagggca gggcccagca cactgcccgg 3420
ccagtcctcc tacctcccga gtctgcgggc agctgctgtc ccagcatctg ctggtcattt 3480
cgccctgaca gtcccaacca gaacccctgg gacttgaatc cagagacgtc ctccaggaac 3540
ccctcaacga agctgtgaat gaagaggttt cctctttaaa cctgtctggt gggcccccag 3600
atatcctcac ctcagggcct cctttttttg caaactcctc ccctcccccg agggcagacc 3660
cagccagctg ctaagctctg cagctcccca gtggacagtg tcattgtgcc cagagtgctg 3720
caaggtgagg cctgctgtgc tgcccgcaca cctgagtgca aaaccaagca ctgtgggcat 3780
ggtgtttccc tctctggggt agagtacgcc ctctcgctgg gcaaagagga agtggcaccc 3840
ctcccctcac cacagatgct gagatggtag catagaaatg atggccgggc gcggtggctc 3900
acgcctgtaa tcccagcact ttgggaggcc gaggcgggcg gatcatgagg tcaggagatc 3960
aagaccaccc tggctaacac ggtgaaaccc catctctact aaaaataaaa aaaaaaatta 4020
gccgggtttg gtggcgtatg cctgtaatcc cagctactcg ggaggctgag gcaggagaat 4080
tgcttaaacc tgggaggtgg aggctgcagt gagccaagat cgtgccactg cactccagcc 4140
tgagtgacag agcaagactc cgtcaaaaaa aaaaaaaaaa aaaaagaaat gatatctggc 4200
ccccccttaa cactggagcc ccactccctt ctcccatccg gcccgagatt agggaggatt 4260
gactgtgtca gggatggcgg gtggcctctc tcgctgccag ggcccttgtc agagcagcca 4320
ggctggacag acggcctccc tcctctccat ctgaccggca cctgctgctt cggggcttag 4380
gccaccgctc cctgtcccca gaggagatag ccccagatgg actggaatgt tgtggcatga 4440
gagcgcatgt gtgcgatggc cccgctgtgg tcccctctct gtccctccat ctgtatgtgt 4500
tctgtgtccc ttgcatgtgt gcgtgttaga gtgagcgcgt atgcatcaac tcattgggct 4560
cttggctgct cacaaggcaa atttgacttg gaaagacttt catctccttg gaaccaagac 4620
ttcctgagtc cccctcaccc tggccctgtt ccaccatggt tatctgggta ttggggaatg 4680
gaaactttgg gggagtgact ttttaaagag acacttataa tttctactac tgcactactg 4740
tccattgtgg gatgattaaa catggtattt aactgtg                          4777

<210> 2
<211> 1049
<212> PRT
<213> Homo sapiens

<400> 2
Met Glu Lys Arg Leu Gly Val Lys Pro Asn Pro Ala Ser Trp Ile Leu
 1               5                  10                  15      
Ser Gly Tyr Tyr Trp Gln Thr Ser Ala Lys Trp Leu Arg Ser Leu Tyr
            20                  25                  30          
Leu Phe Tyr Thr Cys Phe Cys Phe Ser Val Leu Trp Leu Ser Thr Asp
        35                  40                  45              
Ala Ser Glu Ser Arg Cys Gln Gln Gly Lys Thr Gln Phe Gly Val Gly
    50                  55                  60                  
Leu Arg Ser Gly Gly Glu Asn His Leu Trp Leu Leu Glu Gly Thr Pro
65                  70                  75                  80  
Ser Leu Gln Ser Cys Trp Ala Ala Cys Cys Gln Asp Ser Ala Cys His
                85                  90                  95      
Val Phe Trp Trp Leu Glu Gly Met Cys Ile Gln Ala Asp Cys Ser Arg
            100                 105                 110         
Pro Gln Ser Cys Arg Ala Phe Arg Thr His Ser Ser Asn Ser Met Leu
        115                 120                 125             
Val Phe Leu Lys Lys Phe Gln Thr Ala Asp Asp Leu Gly Phe Leu Pro
    130                 135                 140                 
Glu Asp Asp Val Pro His Leu Leu Gly Leu Gly Trp Asn Trp Ala Ser
145                 150                 155                 160 
Trp Arg Gln Ser Pro Pro Arg Ala Ala Leu Arg Pro Ala Val Ser Ser
                165                 170                 175     
Ser Asp Gln Gln Ser Leu Ile Arg Lys Leu Gln Lys Arg Gly Ser Pro
            180                 185                 190         
Ser Asp Val Val Thr Pro Ile Val Thr Gln His Ser Lys Val Asn Asp
        195                 200                 205             
Ser Asn Glu Leu Gly Gly Leu Thr Thr Ser Gly Ser Ala Glu Val His
    210                 215                 220                 
Lys Ala Ile Thr Ile Ser Ser Pro Leu Thr Thr Asp Leu Thr Ala Glu
225                 230                 235                 240 
Leu Ser Gly Gly Pro Lys Asn Val Ser Val Gln Pro Glu Ile Ser Glu
                245                 250                 255     
Gly Leu Ala Thr Thr Pro Ser Thr Gln Gln Val Lys Ser Ser Glu Lys
            260                 265                 270         
Thr Gln Ile Ala Val Pro Gln Pro Val Ala Pro Ser Tyr Ser Tyr Ala
        275                 280                 285             
Thr Pro Thr Pro Gln Ala Ser Phe Gln Ser Thr Ser Ala Pro Tyr Pro
    290                 295                 300                 
Val Ile Lys Glu Leu Val Val Ser Ala Gly Glu Ser Val Gln Ile Thr
305                 310                 315                 320 
Leu Pro Lys Asn Glu Val Gln Leu Asn Ala Tyr Val Leu Gln Glu Pro
                325                 330                 335     
Pro Lys Gly Glu Thr Tyr Thr Tyr Asp Trp Gln Leu Ile Thr His Pro
            340                 345                 350         
Arg Asp Tyr Ser Gly Glu Met Glu Gly Lys His Ser Gln Ile Leu Lys
        355                 360                 365             
Leu Ser Lys Leu Thr Pro Gly Leu Tyr Glu Phe Lys Val Ile Val Glu
    370                 375                 380                 
Gly Gln Asn Ala His Gly Glu Gly Tyr Val Asn Val Thr Val Lys Pro
385                 390                 395                 400 
Glu Pro Arg Lys Asn Arg Pro Pro Ile Ala Ile Val Ser Pro Gln Phe
                405                 410                 415     
Gln Glu Ile Ser Leu Pro Thr Thr Ser Thr Val Ile Asp Gly Ser Gln
            420                 425                 430         
Ser Thr Asp Asp Asp Lys Ile Val Gln Tyr His Trp Glu Glu Leu Lys
        435                 440                 445             
Gly Pro Leu Arg Glu Glu Lys Ile Ser Glu Asp Thr Ala Ile Leu Lys
    450                 455                 460                 
Leu Ser Lys Leu Val Pro Gly Asn Tyr Thr Phe Ser Leu Thr Val Val
465                 470                 475                 480 
Asp Ser Asp Gly Ala Thr Asn Ser Thr Thr Ala Asn Leu Thr Val Asn
                485                 490                 495     
Lys Ala Val Asp Tyr Pro Pro Val Ala Asn Ala Gly Pro Asn Gln Val
            500                 505                 510         
Ile Thr Leu Pro Gln Asn Ser Ile Thr Leu Phe Gly Asn Gln Ser Thr
        515                 520                 525             
Asp Asp His Gly Ile Thr Ser Tyr Glu Trp Ser Leu Ser Pro Ser Ser
    530                 535                 540                 
Lys Gly Lys Val Val Glu Met Gln Gly Val Arg Thr Pro Thr Leu Gln
545                 550                 555                 560 
Leu Ser Ala Met Gln Glu Gly Asp Tyr Thr Tyr Gln Leu Thr Val Thr
                565                 570                 575     
Asp Thr Ile Gly Gln Gln Ala Thr Ala Gln Val Thr Val Ile Val Gln
            580                 585                 590         
Pro Glu Asn Asn Lys Pro Pro Gln Ala Asp Ala Gly Pro Asp Lys Glu
        595                 600                 605             
Leu Thr Leu Pro Val Asp Ser Thr Thr Leu Asp Gly Ser Lys Ser Ser
    610                 615                 620                 
Asp Asp Gln Lys Ile Ile Ser Tyr Leu Trp Glu Lys Thr Gln Gly Pro
625                 630                 635                 640 
Asp Gly Val Gln Leu Glu Asn Ala Asn Ser Ser Val Ala Thr Val Thr
                645                 650                 655     
Gly Leu Gln Val Gly Thr Tyr Val Phe Thr Leu Thr Val Lys Asp Glu
            660                 665                 670         
Arg Asn Leu Gln Ser Gln Ser Ser Val Asn Val Ile Val Lys Glu Glu
        675                 680                 685             
Ile Asn Lys Pro Pro Ile Ala Lys Ile Thr Gly Asn Val Val Ile Thr
    690                 695                 700                 
Leu Pro Thr Ser Thr Ala Glu Leu Asp Gly Ser Lys Ser Ser Asp Asp
705                 710                 715                 720 
Lys Gly Ile Val Ser Tyr Leu Trp Thr Arg Asp Glu Gly Ser Pro Ala
                725                 730                 735     
Ala Gly Glu Val Leu Asn His Ser Asp His His Pro Ile Leu Phe Leu
            740                 745                 750         
Ser Asn Leu Val Glu Gly Thr Tyr Thr Phe His Leu Lys Val Thr Asp
        755                 760                 765             
Ala Lys Gly Glu Ser Asp Thr Asp Arg Thr Thr Val Glu Val Lys Pro
    770                 775                 780                 
Asp Pro Arg Lys Asn Asn Leu Val Glu Ile Ile Leu Asp Ile Asn Val
785                 790                 795                 800 
Ser Gln Leu Thr Glu Arg Leu Lys Gly Met Phe Ile Arg Gln Ile Gly
                805                 810                 815     
Val Leu Leu Gly Val Leu Asp Ser Asp Ile Ile Val Gln Lys Ile Gln
            820                 825                 830         
Pro Tyr Thr Glu Gln Ser Thr Lys Met Val Phe Phe Val Gln Asn Glu
        835                 840                 845             
Pro Pro His Gln Ile Phe Lys Gly His Glu Val Ala Ala Met Leu Lys
    850                 855                 860                 
Ser Glu Leu Arg Lys Gln Lys Ala Asp Phe Leu Ile Phe Arg Ala Leu
865                 870                 875                 880 
Glu Val Asn Thr Val Thr Cys Gln Leu Asn Cys Ser Asp His Gly His
                885                 890                 895     
Cys Asp Ser Phe Thr Lys Arg Cys Ile Cys Asp Pro Phe Trp Met Glu
            900                 905                 910         
Asn Phe Ile Lys Val Gln Leu Arg Asp Gly Asp Ser Asn Cys Glu Trp
        915                 920                 925             
Ser Val Leu Tyr Val Ile Ile Ala Thr Phe Val Ile Val Val Ala Leu
    930                 935                 940                 
Gly Ile Leu Ser Trp Thr Val Ile Cys Cys Cys Lys Arg Gln Lys Gly
945                 950                 955                 960 
Lys Pro Lys Arg Lys Ser Lys Tyr Lys Ile Leu Asp Ala Thr Asp Gln
                965                 970                 975     
Glu Ser Leu Glu Leu Lys Pro Thr Ser Arg Ala Gly Ile Lys Gln Lys
            980                 985                 990         
Gly Leu Leu Leu Ser Ser Ser Leu Met His Ser Glu Ser Glu Leu Asp
        995                 1000                1005            
Ser Asp Asp Ala Ile Phe Thr Trp Pro Asp Arg Glu Lys Gly Lys Leu
    1010                1015                1020                
Leu His Gly Gln Asn Gly Ser Val Pro Asn Gly Gln Thr Pro Leu Lys
1025                1030                1035               1040 
Ala Arg Ser Pro Arg Glu Glu Ile Leu
                1045                

<210> 3
<211> 5173
<212> DNA
<213> Homo sapiens

<400> 3
gtgcaatcgc gggaagccag ggtttccagc taggacacag caggtcgtga tccgggtcgg 60
gacactgcct ggcagaggct gcgagcatgg ggccctgggg ctggaaattg cgctggaccg 120
tcgccttgct cctcgccgcg gcggggactg cagtgggcga cagatgcgaa agaaacgagt 180
tccagtgcca agacgggaaa tgcatctcct acaagtgggt ctgcgatggc agcgctgagt 240
gccaggatgg ctctgatgag tcccaggaga cgtgcttgtc tgtcacctgc aaatccgggg 300
acttcagctg tgggggccgt gtcaaccgct gcattcctca gttctggagg tgcgatggcc 360
aagtggactg cgacaacggc tcagacgagc aaggctgtcc ccccaagacg tgctcccagg 420
acgagtttcg ctgccacgat gggaagtgca tctctcggca gttcgtctgt gactcagacc 480
gggactgctt ggacggctca gacgaggcct cctgcccggt gctcacctgt ggtcccgcca 540
gcttccagtg caacagctcc acctgcatcc cccagctgtg ggcctgcgac aacgaccccg 600
actgcgaaga tggctcggat gagtggccgc agcgctgtag gggtctttac gtgttccaag 660
gggacagtag cccctgctcg gccttcgagt tccactgcct aagtggcgag tgcatccact 720
ccagctggcg ctgtgatggt ggccccgact gcaaggacaa atctgacgag gaaaactgcg 780
ctgtggccac ctgtcgccct gacgaattcc agtgctctga tggaaactgc atccatggca 840
gccggcagtg tgaccgggaa tatgactgca aggacatgag cgatgaagtt ggctgcgtta 900
atgtgacact ctgcgaggga cccaacaagt tcaagtgtca cagcggcgaa tgcatcaccc 960
tggacaaagt ctgcaacatg gctagagact gccgggactg gtcagatgaa cccatcaaag 1020
agtgcgggac caacgaatgc ttggacaaca acggcggctg ttcccacgtc tgcaatgacc 1080
ttaagatcgg ctacgagtgc ctgtgccccg acggcttcca gctggtggcc cagcgaagat 1140
gcgaagatat cgatgagtgt caggatcccg acacctgcag ccagctctgc gtgaacctgg 1200
agggtggcta caagtgccag tgtgaggaag gcttccagct ggacccccac acgaaggcct 1260
gcaaggctgt gggctccatc gcctacctct tcttcaccaa ccggcacgag gtcaggaaga 1320
tgacgctgga ccggagcgag tacaccagcc tcatccccaa cctgaggaac gtggtcgctc 1380
tggacacgga ggtggccagc aatagaatct actggtctga cctgtcccag agaatgatct 1440
gcagcaccca gcttgacaga gcccacggcg tctcttccta tgacaccgtc atcagcagag 1500
acatccaggc ccccgacggg ctggctgtgg actggatcca cagcaacatc tactggaccg 1560
actctgtcct gggcactgtc tctgttgcgg ataccaaggg cgtgaagagg aaaacgttat 1620
tcagggagaa cggctccaag ccaagggcca tcgtggtgga tcctgttcat ggcttcatgt 1680
actggactga ctggggaact cccgccaaga tcaagaaagg gggcctgaat ggtgtggaca 1740
tctactcgct ggtgactgaa aacattcagt ggcccaatgg catcacccta gatctcctca 1800
gtggccgcct ctactgggtt gactccaaac ttcactccat ctcaagcatc gatgtcaacg 1860
ggggcaaccg gaagaccatc ttggaggatg aaaagaggct ggcccacccc ttctccttgg 1920
ccgtctttga ggacaaagta ttttggacag atatcatcaa cgaagccatt ttcagtgcca 1980
accgcctcac aggttccgat gtcaacttgt tggctgaaaa cctactgtcc ccagaggata 2040
tggttctctt ccacaacctc acccagccaa gaggagtgaa ctggtgtgag aggaccaccc 2100
tgagcaatgg cggctgccag tatctgtgcc tccctgcccc gcagatcaac ccccactcgc 2160
ccaagtttac ctgcgcctgc ccggacggca tgctgctggc cagggacatg aggagctgcc 2220
tcacagaggc tgaggctgca gtggccaccc aggagacatc caccgtcagg ctaaaggtca 2280
gctccacagc cgtaaggaca cagcacacaa ccacccgacc tgttcccgac acctcccggc 2340
tgcctggggc cacccctggg ctcaccacgg tggagatagt gacaatgtct caccaagctc 2400
tgggcgacgt tgctggcaga ggaaatgaga agaagcccag tagcgtgagg gctctgtcca 2460
ttgtcctccc catcgtgctc ctcgtcttcc tttgcctggg ggtcttcctt ctatggaaga 2520
actggcggct taagaacatc aacagcatca actttgacaa ccccgtctat cagaagacca 2580
cagaggatga ggtccacatt tgccacaacc aggacggcta cagctacccc tcgagacaga 2640
tggtcagtct ggaggatgac gtggcgtgaa catctgcctg gagtcccgtc cctgcccaga 2700
acccttcctg agacctcgcc ggccttgttt tattcaaaga cagagaagac caaagcattg 2760
cctgccagag ctttgtttta tatatttatt catctgggag gcagaacagg cttcggacag 2820
tgcccatgca atggcttggg ttgggatttt ggtttcttcc tttcctcgtg aaggataaga 2880
gaaacaggcc cggggggacc aggatgacac ctccatttct ctccaggaag ttttgagttt 2940
ctctccaccg tgacacaatc ctcaaacatg gaagatgaaa ggggagggga tgtcaggccc 3000
agagaagcaa gtggctttca acacacaaca gcagatggca ccaacgggac cccctggccc 3060
tgcctcatcc accaatctct aagccaaacc cctaaactca ggagtcaacg tgtttacctc 3120
ttctatgcaa gccttgctag acagccaggt tagcctttgc cctgtcaccc ccgaatcatg 3180
acccacccag tgtctttcga ggtgggtttg taccttcctt aagccaggaa agggattcat 3240
ggcgtcggaa atgatctggc tgaatccgtg gtggcaccga gaccaaactc attcaccaaa 3300
tgatgccact tcccagaggc agagcctgag tcactggtca cccttaatat ttattaagtg 3360
cctgagacac ccggttacct tggccgtgag gacacgtggc ctgcacccag gtgtggctgt 3420
caggacacca gcctggtgcc catcctcccg acccctaccc acttccattc ccgtggtctc 3480
cttgcacttt ctcagttcag agttgtacac tgtgtacatt tggcatttgt gttattattt 3540
tgcactgttt tctgtcgtgt gtgttgggat gggatcccag gccagggaaa gcccgtgtca 3600
atgaatgccg gggacagaga ggggcaggtt gaccgggact tcaaagccgt gatcgtgaat 3660
atcgagaact gccattgtcg tctttatgtc cgcccaccta gtgcttccac ttctatgcaa 3720
atgcctccaa gccattcact tccccaatct tgtcgttgat gggtatgtgt ttaaaacatg 3780
cacggtgagg ccgggcgcag tggctcacgc ctgtaatccc agcactttgg gaggccgagg 3840
cgggtggatc atgaggtcag gagatcgaga ccatcctggc taacacgtga aaccccgtct 3900
ctactaaaaa tacaaaaaat tagccgggcg tggtggcggg cacctgtagt cccagctact 3960
cgggaggctg aggcaggaga atggtgtgaa cccgggaagc ggagcttgca gtgagccgag 4020
attgcgccac tgcagtccgc agtctggcct gggcgacaga gcgagactcc gtctcaaaaa 4080
aaaaaaacaa aaaaaaacca tgcatggtgc atcagcagcc catggcctct ggccaggcat 4140
ggcgaggctg aggtgggagg atggtttgag ctcaggcatt tgaggctgtc gtgagctatg 4200
attatgccac tgctttccag cctgggcaac atagtaagac cccatctctt aaaaaatgaa 4260
tttggccaga cacaggtgcc tcacgcctgt aatcccagca ctttgggagg ctgagctgga 4320
tcacttgagt tcaggagttg gagaccaggc ctgagcaaca aagcgagatc ccatctctac 4380
aaaaaccaaa aagttaaaaa tcagctgggt acggtggcac gtgcctgtga tcccagctac 4440
ttgggaggct gaggcaggag gatcgcctga gcccaggagg tggaggttgc agtgagccat 4500
gatcgagcca ctgcactcca gcctgggcaa cagatgaaga ccctatttca gaaatacaac 4560
tataaaaaaa taaataaatc ctccagtctg gatcgtttga cgggacttca ggttctttct 4620
gaaatcgccg tgttactgtt gcactgatgt ccggagagac agtgacagcc tccgtcagac 4680
tcccgcgtga agatgtcaca agggattggc aattgtcccc agggacaaaa cactgtgtcc 4740
cccccagtgc agggaaccgt gataagcctt tctggtttcg gagcacgtaa atgcgtccct 4800
gtacagatag tggggatttt ttgttatgtt tgcactttgt atattggttg aaactgttat 4860
cacttatata tatatatata cacacatata tataaaatct atttattttt gcaaaccctg 4920
gttgctgtat ttgttcagtg actattctcg gggccctgtg tagggggtta ttgcctctga 4980
aatgcctctt ctttatgtac aaagattatt tgcacgaact ggactgtgtg caacgctttt 5040
tgggagaatg atgtccccgt tgtatgtatg agtggcttct gggagatggg tgtcactttt 5100
taaaccactg tatagaaggt ttttgtagcc tgaatgtctt actgtgatca attaaatttc 5160
ttaaatgaac caa                                                    5173

<210> 4
<211> 860
<212> PRT
<213> Homo sapiens

<400> 4
Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu
 1               5                  10                  15      
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe
            20                  25                  30          
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly
        35                  40                  45              
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu
    50                  55                  60                  
Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn
65                  70                  75                  80  
Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp
                85                  90                  95      
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp
            100                 105                 110         
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys
        115                 120                 125             
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
    130                 135                 140                 
Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys
145                 150                 155                 160 
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly
                165                 170                 175     
Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly
            180                 185                 190         
Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu
        195                 200                 205             
Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp
    210                 215                 220                 
Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu
225                 230                 235                 240 
Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp
                245                 250                 255     
Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn
            260                 265                 270         
Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu
        275                 280                 285             
Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp
    290                 295                 300                 
Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp
305                 310                 315                 320 
Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr
                325                 330                 335     
Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys
            340                 345                 350         
Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys
        355                 360                 365             
Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln
    370                 375                 380                 
Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr
385                 390                 395                 400 
Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg
                405                 410                 415     
Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu
            420                 425                 430         
Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln
        435                 440                 445             
Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser
    450                 455                 460                 
Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala
465                 470                 475                 480 
Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly
                485                 490                 495     
Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe
            500                 505                 510         
Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His
        515                 520                 525             
Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys
    530                 535                 540                 
Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile
545                 550                 555                 560 
Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr
                565                 570                 575     
Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly
            580                 585                 590         
Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro
        595                 600                 605             
Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile
    610                 615                 620                 
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn
625                 630                 635                 640 
Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His
                645                 650                 655     
Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu
            660                 665                 670         
Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn
        675                 680                 685             
Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu
    690                 695                 700                 
Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala
705                 710                 715                 720 
Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val
                725                 730                 735     
Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu
            740                 745                 750         
Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser
        755                 760                 765             
His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro
    770                 775                 780                 
Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val
785                 790                 795                 800 
Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys
                805                 810                 815     
Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr
            820                 825                 830         
Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro
        835                 840                 845             
Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala
    850                 855                 860 

<210> 5
<211> 5292
<212> DNA
<213> Homo sapiens

<400> 5
gcagcctggg cagtgggtcc tgcctgtgac gcgcggcggc ggtcggtcct gcctgtaacg 60
gcggcggcgg ctgctgctcc ggacacctgc ggcggcggcg gcgaccccgc ggcgggcgcg 120
gagatgtggc ccctggtagc ggcgctgttg ctgggctcgg cgtgctgcgg atcagctcag 180
ctactattta ataaaacaaa atctgtagaa ttcacgtttt gtaatgacac tgtcgtcatt 240
ccatgctttg ttactaatat ggaggcacaa aacactactg aagtatacgt aaagtggaaa 300
tttaaaggaa gagatattta cacctttgat ggagctctaa acaagtccac tgtccccact 360
gactttagta gtgcaaaaat tgaagtctca caattactaa aaggagatgc ctctttgaag 420
atggataaga gtgatgctgt ctcacacaca ggaaactaca cttgtgaagt aacagaatta 480
accagagaag gtgaaacgat catcgagcta aaatatcgtg ttgtttcatg gttttctcca 540
aatgaaaata ttcttattgt tattttccca atttttgcta tactcctgtt ctggggacag 600
tttggtatta aaacacttaa atatagatcc ggtggtatgg atgagaaaac aattgcttta 660
cttgttgctg gactagtgat cactgtcatt gtcattgttg gagccattct tttcgtccca 720
ggtgaatatt cattaaagaa tgctactggc cttggtttaa ttgtgacttc tacagggata 780
ttaatattac ttcactacta tgtgtttagt acagcgattg gattaacctc cttcgtcatt 840
gccatattgg ttattcaggt gatagcctat atcctcgctg tggttggact gagtctctgt 900
attgcggcgt gtataccaat gcatggccct cttctgattt caggtttgag tatcttagct 960
ctagcacaat tacttggact agtttatatg aaatttgtgg cttccaatca gaagactata 1020
caacctccta ggaaagctgt agaggaaccc cttaatgcat tcaaagaatc aaaaggaatg 1080
atgaatgatg aataactgaa gtgaagtgat ggactccgat ttggagagta gtaagacgtg 1140
aaaggaatac acttgtgttt aagcaccatg gccttgatga ttcactgttg gggagaagaa 1200
acaagaaaag taactggttg tcacctatga gacccttacg tgattgttag ttaagttttt 1260
attcaaagca gctgtaattt agttaataaa ataattatga tctatgttgt ttgcccaatt 1320
gagatccagt tttttgttgt tatttttaat caattagggg caatagtaga atggacaatt 1380
tccaagaatg atgcctttca ggtcctaggg cctctggcct ctaggtaacc agtttaaatt 1440
ggttcagggt gataactact tagcactgcc ctggtgatta cccagagata tctatgaaaa 1500
ccagtggctt ccatcaaacc tttgccaact caggttcaca gcagctttgg gcagttatgg 1560
cagtatggca ttagctgaga ggtgtctgcc acttctgggt caatggaata ataaattaag 1620
tacaggcagg aatttggttg ggagcatctt gtatgatctc cgtatgatgt gatattgatg 1680
gagatagtgg tcctcattct tgggggttgc cattcccaca ttcccccttc aacaaacagt 1740
gtaacaggtc cttcccagat ttagggtact tttattgatg gatatgtttt ccttttattc 1800
acataacccc ttgaaaccct gtcttgtcct cctgttactt gcttctgctg tacaagatgt 1860
agcacctttt ctcctctttg aacatggtct agtgacacgg tagcaccagt tgcaggaagg 1920
agccagactt gttctcagag cactgtgttc acacttttca gcaaaaatag ctatggttgt 1980
aacatatgta ttcccttcct ctgatttgaa ggcaaaaatc tacagtgttt cttcacttct 2040
tttctgatct ggggcatgaa aaaagcaaga ttgaaatttg aactatgagt ctcctgcatg 2100
gcaacaaaat gtgtgtcacc atcaggccaa caggccagcc cttgaatggg gatttattac 2160
tgttgtatct atgttgcatg ataaacattc atcaccttcc tcctgtagtc ctgcctcgta 2220
ctccccttcc cctatgattg aaaagtaaac aaaacccaca tttcctatcc tggttagaag 2280
aaaattaatg ttctgacagt tgtgatcgcc tggagtactt ttagactttt agcattcgtt 2340
ttttacctgt ttgtggatgt gtgtttgtat gtgcatacgt atgagatagg cacatgcatc 2400
ttctgtatgg acaaaggtgg ggtacctaca ggagagcaaa ggttaatttt gtgcttttag 2460
taaaaacatt taaatacaaa gttctttatt gggtggaatt atatttgatg caaatatttg 2520
atcacttaaa acttttaaaa cttctaggta atttgccacg ctttttgact gctcaccaat 2580
accctgtaaa aatacgtaat tcttcctgtt tgtgtaataa gatattcata tttgtagttg 2640
cattaataat agttatttct tagtccatca gatgttcccg tgtgcctctt ttatgccaaa 2700
ttgattgtca tatttcatgt tgggaccaag tagtttgccc atggcaaacc taaatttatg 2760
acctgctgag gcctctcaga aaactgagca tactagcaag acagctcttc ttgaaaaaaa 2820
aaatatgtat acacaaatat atacgtatat ctatatatac gtatgtatat acacacatgt 2880
atattcttcc ttgattgtgt agctgtccaa aataataaca tatatagagg gagctgtatt 2940
cctttataca aatctgatgg ctcctgcagc actttttcct tctgaaaata tttacatttt 3000
gctaacctag tttgttactt taaaaatcag ttttgatgaa aggagggaaa agcagatgga 3060
cttgaaaaag atccaagctc ctattagaaa aggtatgaaa atctttatag taaaattttt 3120
tataaactaa agttgtacct tttaatatgt agtaaactct catttatttg gggttcgctc 3180
ttggatctca tccatccatt gtgttctctt taatgctgcc tgccttttga ggcattcact 3240
gccctagaca atgccaccag agatagtggg ggaaatgcca gatgaaacca actcttgctc 3300
tcactagttg tcagcttctc tggataagtg accacagaag caggagtcct cctgcttggg 3360
catcattggg ccagttcctt ctctttaaat cagatttgta atggctccca aattccatca 3420
catcacattt aaattgcaga cagtgttttg cacatcatgt atctgttttg tcccataata 3480
tgctttttac tccctgatcc cagtttctgc tgttgactct tccattcagt tttatttatt 3540
gtgtgttctc acagtgacac catttgtcct tttctgcaac aacctttcca gctacttttg 3600
ccaaattcta tttgtcttct ccttcaaaac attctccttt gcagttcctc ttcatctgtg 3660
tagctgctct tttgtctctt aacttaccat tcctatagta ctttatgcat ctctgcttag 3720
ttctattagt tttttggcct tgctcttctc cttgatttta aaattccttc tatagctaga 3780
gcttttcttt ctttcattct ctcttcctgc agtgttttgc atacatcaga agctaggtac 3840
ataagttaaa tgattgagag ttggctgtat ttagatttat cactttttaa tagggtgagc 3900
ttgagagttt tctttctttc tgtttttttt ttttgttttt tttttttttt tttttttttt 3960
tttttttgac taatttcaca tgctctaaaa accttcaaag gtgattattt ttctcctgga 4020
aactccaggt ccattctgtt taaatcccta agaatgtcag aattaaaata acagggctat 4080
cccgtaattg gaaatatttc ttttttcagg atgctatagt caatttagta agtgaccacc 4140
aaattgttat ttgcactaac aaagctcaaa acacgataag tttactcctc catctcagta 4200
ataaaaatta agctgtaatc aaccttctag gtttctcttg tcttaaaatg ggtattcaaa 4260
aatggggatc tgtggtgtat gtatggaaac acatactcct taatttacct gttgttggaa 4320
actggagaaa tgattgtcgg gcaaccgttt attttttatt gtattttatt tggttgaggg 4380
atttttttat aaacagtttt acttgtgtca tattttaaaa ttactaactg ccatcacctg 4440
ctggggtcct ttgttaggtc attttcagtg actaataggg ataatccagg taactttgaa 4500
gagatgagca gtgagtgacc aggcagtttt tctgccttta gctttgacag ttcttaatta 4560
agatcattga agaccagctt tctcataaat ttctcttttt gaaaaaaaga aagcatttgt 4620
actaagctcc tctgtaagac aacatcttaa atcttaaaag tgttgttatc atgactggtg 4680
agagaagaaa acattttgtt tttattaaat ggagcattat ttacaaaaag ccattgttga 4740
gaattagatc ccacatcgta taaatatcta ttaaccattc taaataaaga gaactccagt 4800
gttgctatgt gcaagatcct ctcttggagc ttttttgcat agcaattaaa ggtgtgctat 4860
ttgtcagtag ccattttttt gcagtgattt gaagaccaaa gttgttttac agctgtgtta 4920
ccgttaaagg tttttttttt tatatgtatt aaatcaattt atcactgttt aaagctttga 4980
atatctgcaa tctttgccaa ggtacttttt tatttaaaaa aaaacataac tttgtaaata 5040
ttaccctgta atattatata tacttaataa aacattttaa gctattttgt tgggctattt 5100
ctattgctgc tacagcagac cacaagcaca tttctgaaaa atttaattta ttaatgtatt 5160
tttaagttgc ttatattcta ggtaacaatg taaagaatga tttaaaatat taattatgaa 5220
ttttttgagt ataataccca ataagctttt aattagagca gagttttaat taaaagtttt 5280
aaatcagtcc aa                                                     5292

<210> 6
<211> 323
<212> PRT
<213> Homo sapiens

<400> 6
Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly
 1               5                  10                  15      
Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe
            20                  25                  30          
Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala
        35                  40                  45              
Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp
    50                  55                  60                  
Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp
65                  70                  75                  80  
Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala
                85                  90                  95      
Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr
            100                 105                 110         
Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu
        115                 120                 125             
Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu
    130                 135                 140                 
Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe
145                 150                 155                 160 
Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr
                165                 170                 175     
Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val
            180                 185                 190         
Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr
        195                 200                 205             
Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His
    210                 215                 220                 
Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala
225                 230                 235                 240 
Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu
                245                 250                 255     
Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile
            260                 265                 270         
Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr
        275                 280                 285             
Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys
    290                 295                 300                 
Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met
305                 310                 315                 320 
Asn Asp Glu
           

<210> 7
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<220> 
<221> VARIANT        
<222> 10, 15, 20, 25
<223> Xaa = absent or Ser

<220> 
<221> VARIANT        
<222> 6-9, 11-14, 16-19, 21-24
<223> Xaa = absent or Gly

<400> 7
Gly Gly Gly Gly Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10                  15      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25  

