                         SEQUENCE LISTING

<110>  BioAtla, Inc.
 
<120>  METHODS OF TREATING AXL-EXRPRESSING CANCERS WITH ANTI-AXL 
       ANTIBODIES, ANTIBODY FRAGMENTS AND THEIR IMMUNOCONJUGATES

<130>  BIAT-1034WO

<150>  63/113,040
<151>  November 12, 2020

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1 sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is T or A or W

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is H or A

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is T or I

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is N or I

<400>  1

Xaa Gly Xaa Xaa Met Xaa 
1               5       


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2 sequence


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is P or N

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa is S or I or T

<400>  2

Leu Ile Lys Xaa Ser Asn Gly Gly Thr Xaa Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3 sequence


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is H or D or E or P or R or W

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Y or N

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is E or A or D or F or G or H or I or L or M or N or R or V 
       or Y

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is S or D or M or N or Q

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is Y or C or E or P

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is F or E or N or S or T or V

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is A or D or G or L or Y

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is M or E or F

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is W or A or D or H or L or N or P or R or T

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa is G or H

<400>  3

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Tyr Xaa Xaa 
1               5                   10              


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L1 sequence


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is V or D or G or N or W

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is S or V

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is A or L or M

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa is A or D or N or Q

<400>  4

Lys Ala Ser Gln Asp Xaa Xaa Ser Xaa Val Xaa 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L2 sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is W or F

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is A or I or N or P or Q

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is S or D

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is H or D

<400>  5

Trp Xaa Xaa Thr Arg Xaa Thr 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L3 sequence


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is H or C or F or I or L or Q or S or T or V or Y

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is F or C or D or E or G or N or S

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is T or C or P

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is P or A or C or D or E or H or K or S or T or V or W

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is L or G or R

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is T or I or R

<400>  6

Gln Glu Xaa Xaa Ser Xaa Xaa Xaa Xaa 
1               5                   


<210>  7
<211>  323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region sequence

<400>  7
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aggccagtca ggatgtggtt tctgctgtag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctattgg caggataccc ggcacactgg agtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgtcaggaa cattttagca ctccgctcac gttcggccaa      300

gggaccaagg tggaaatcaa acc                                              323


<210>  8
<211>  323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region sequence

<400>  8
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aggccagtca ggatgtgagt tctgctgtag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctattgg caggataccc ggcacactgg agtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgtcaggaa cattttagcc ctccgctcac gttcggccaa      300

gggaccaagg tggaaatcaa acc                                              323


<210>  9
<211>  323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region sequence

<400>  9
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aggccagtca ggatgtggtt tctgctgtag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctattgg caggataccc ggcacactgg agtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgtcaggaa cattttagcc ctccgctcac gttcggccaa      300

gggaccaagg tggaaatcaa acc                                              323


<210>  10
<211>  323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region sequence

<400>  10
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aggccagtca ggatgtggtt tctgctgtag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctattgg caggataccc ggcacactgg agtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgtcaggaa cattttagcc ctccgctcag gttcggccaa      300

gggaccaagg tggaaatcaa acc                                              323


<210>  11
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region sequence

<400>  11
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc       60

tcctgcaagg tttctggtta ctcattcact ggcgctacca tgaactggat ccgccagccc      120

ccagggaagg ggctggagtg gattggtctt attaaacctt ccaatggtgg tactagttac      180

aaccagaagt tcaagggcag agtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acatggtcac      300

tacgagagtt acgaggctat ggactactgg ggccagggaa cgctggtcac cgtcagctca      360


<210>  12
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region sequence

<400>  12
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc       60

tcctgcaagg tttctggtta ctcattctgg ggcgctacca tgaactggat ccgccagccc      120

ccagggaagg ggctggagtg gattggtctt attaaacctt ccaatggtgg tactagttac      180

aaccagaagt tcaagggcag agtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acatggtcac      300

tacgagagtt acgaggctat ggactactgg ggccagggaa cgctggtcac cgtcagctca      360


<210>  13
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region sequence

<400>  13
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc       60

tcctgcaagg tttctggtta ctcattcact ggccacacca tgaactggat ccgccagccc      120

ccagggaagg ggctggagtg gattggtctt attaaacctt ccaatggtgg tactagttac      180

aaccagaagt tcaagggcag agtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acatggtcac      300

tacgagagtt acgaggctat ggactactgg ggccagggaa cgctggtcac cgtcagctca      360


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hcCDR1

<400>  14

Trp Gly Ala Thr Met Asn 
1               5       


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hcCDR2

<400>  15

Leu Ile Lys Pro Ser Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hcCDR3

<400>  16

Gly His Tyr Glu Ser Tyr Glu Ala Met Asp Tyr Trp Gly 
1               5                   10              


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lcCDR1

<400>  17

Lys Ala Ser Gln Asp Val Val Ser Ala Val Ala 
1               5                   10      


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lcCDR2

<400>  18

Trp Gln Asp Thr Arg His Thr 
1               5           


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lcCDR3

<400>  19

Gln Glu His Phe Ser Pro Pro Leu Thr 
1               5                   


<210>  20
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  20

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Trp Gly Ala 
            20                  25                  30          


Thr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Lys Pro Ser Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly His Tyr Glu Ser Tyr Glu Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  21
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Val Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Trp Gln Asp Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Glu His Phe Ser Pro Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


