                         SEQUENCE LISTING

<110>  BicycleTx Limited
 
<120>  BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TRANSFERRIN RECEPTOR 1 
       (TfR1)

<130>  BIC-C-P2924PCT

<150>  GB 2017927.1
<151>  2020-11-13

<150>  GB 2106903.4
<151>  2021-05-14

<150>  US 63/261,820
<151>  2021-09-29

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  1

Cys Ala Leu Cys Asn Asp Trp Thr Leu Pro Trp His His Cys 
1               5                   10                  


<210>  2
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  2

Cys Arg Glu Phe Phe Asp Thr Cys Gly Leu Ala Phe Ile Glu Cys 
1               5                   10                  15  


<210>  3
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  3

Cys Leu Glu Ala Cys Tyr Asp Gly Val Tyr Trp Tyr Ser Cys 
1               5                   10                  


<210>  4
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  4

Cys Ser Ala Asp Asp Trp Leu Gly Cys Ile Ser Trp Cys 
1               5                   10              


<210>  5
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  5

Cys Ser Ser Asp Ala Tyr Leu Gly Cys Ile Ser Trp Cys 
1               5                   10              


<210>  6
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  6

Cys Pro Pro Asp Ala His Leu Gly Cys Ile Ser Trp Cys 
1               5                   10              


<210>  7
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  7

Cys Pro Gln Asp Ala Tyr Leu Gly Cys Ile Ser Trp Cys 
1               5                   10              


<210>  8
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  8

Cys Pro Pro Asp Ser Trp Gln Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  9
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  9

Cys Ser Pro Asp Ala His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  10

Cys Pro Gly Asp Ala His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  11

Cys Pro Pro Asp Ser His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  12
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  12

Cys Ser Ala Asp Asp Trp Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  13
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is HyP

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is tBuGly

<400>  13

Cys Pro Xaa Asp Ala Tyr Leu Gly Cys Xaa Ser Tyr Cys 
1               5                   10              


<210>  14
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is HyP

<400>  14

Cys Pro Xaa Asp Ala Tyr Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  15
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is HyP

<400>  15

Cys Ser Xaa Asp Ala His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  16
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is Aib

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is tBuGly

<400>  16

Cys Pro Xaa Asp Ala His Leu Gly Cys Xaa Ser Tyr Cys 
1               5                   10              


<210>  17
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  17

Cys Pro Pro Asp Ala His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  18
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is Aib

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is tBuGly

<400>  18

Cys Pro Xaa Asp Ala Tyr Leu Gly Cys Xaa Ser Tyr Cys 
1               5                   10              


<210>  19
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  19

Cys Ser Ala Asp Ala His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  20
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is Aib

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is tBuGly

<400>  20

Cys Ser Xaa Asp Ala His Leu Gly Cys Xaa Ser Tyr Cys 
1               5                   10              


<210>  21
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is EPA

<400>  21

Cys Ser Pro Asp Ala His Leu Gly Cys Xaa Ser Tyr Cys 
1               5                   10              


<210>  22
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is tBuGly

<400>  22

Cys Pro Pro Asp Ala Tyr Leu Gly Cys Xaa Ser Tyr Cys 
1               5                   10              


<210>  23
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is Aib

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is tBuGly

<400>  23

Cys Ser Xaa Asp Ala Tyr Leu Gly Cys Xaa Ser Tyr Cys 
1               5                   10              


<210>  24
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  24

Cys Ala Pro Asp Ala His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  25
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is Aib

<400>  25

Cys Pro Xaa Asp Ala His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  26
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is tBuGly

<400>  26

Cys Ser Pro Asp Ala Tyr Leu Gly Cys Xaa Ser Tyr Cys 
1               5                   10              


<210>  27
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is tBuGly

<400>  27

Cys Ser Pro Asp Ala His Leu Gly Cys Xaa Ser Tyr Cys 
1               5                   10              


<210>  28
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  28

Cys Pro Asn Asp Ala His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  29
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  29

Cys Pro Ile Asp Ala His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  30
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  30

Cys Ser Pro Asp Ala Tyr Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  31
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  31

Cys Pro Pro Asp Ala Tyr Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  32
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is Aib

<400>  32

Cys Ser Xaa Asp Ala His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  33
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is Chg

<400>  33

Cys Ser Pro Asp Ala His Leu Gly Cys Xaa Ser Tyr Cys 
1               5                   10              


<210>  34
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  34

Cys Ala Pro Asp Ala His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  35
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa is tBuAla

<400>  35

Cys Tyr Leu Pro Asp Trp Xaa Cys Gly Asp Glu Tyr Cys 
1               5                   10              


<210>  36
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (12)..(12)
<223>  Xaa is 2Nal

<400>  36

Cys Ser Pro Asp Ala His Leu Gly Cys Ile Ser Xaa Cys 
1               5                   10              


<210>  37
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (12)..(12)
<223>  Xaa is 3tBuTyr

<400>  37

Cys Ser Pro Asp Ala His Leu Gly Cys Ile Ser Xaa Cys 
1               5                   10              


<210>  38
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is Aib

<400>  38

Cys Ser Pro Asp Xaa His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  39
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (12)..(12)
<223>  Xaa is 1Nal

<400>  39

Cys Ser Pro Asp Ala His Leu Gly Cys Ile Ser Xaa Cys 
1               5                   10              


<210>  40
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa is tBuAla

<400>  40

Cys Ser Pro Asp Ala His Xaa Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  41
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa is Cba

<400>  41

Cys Ser Pro Asp Ala His Xaa Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  42
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  42

Cys Ser Pro Asp Ala His Leu Gly Cys Ile Ser Trp Cys 
1               5                   10              


<210>  43
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is Abu

<400>  43

Cys Ser Pro Asp Xaa His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  44
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is Aze

<400>  44

Cys Ser Xaa Asp Ala His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  45
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  45

Cys Ser Pro Asp Asp His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  46
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  46

Cys Ser Pro Asp Ser His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  47
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa is Abu

<400>  47

Cys Ser Pro Asp Ala His Xaa Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  48
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (12)..(12)
<223>  Xaa is 4Pal

<400>  48

Cys Ser Pro Asp Ala His Leu Gly Cys Ile Ser Xaa Cys 
1               5                   10              


<210>  49
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  49

Cys Pro Ala Asp Ala His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  50
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is tBuAla

<400>  50

Cys Ser Pro Asp Ala Tyr Leu Gly Cys Xaa Ser Tyr Cys 
1               5                   10              


<210>  51
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is C5g

<400>  51

Cys Ser Pro Asp Ala His Leu Gly Cys Xaa Ser Tyr Cys 
1               5                   10              


<210>  52
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is Cbg

<400>  52

Cys Ser Pro Asp Ala His Leu Gly Cys Xaa Ser Tyr Cys 
1               5                   10              


<210>  53
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  53

Cys Ser Pro Asp Ala His Leu Ala Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  54
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa is Aib

<400>  54

Cys Ser Pro Asp Ala His Xaa Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  55
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is Cpg

<400>  55

Cys Ser Pro Asp Ala His Leu Gly Cys Xaa Ser Tyr Cys 
1               5                   10              


<210>  56
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is B-Melle

<400>  56

Cys Ser Pro Asp Ala His Leu Gly Cys Xaa Ser Tyr Cys 
1               5                   10              


<210>  57
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  57

Cys Ser Ala Asp Ala His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  58
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  58

Cys Ser Pro Ala Ala His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  59
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  59

Cys Ser Pro Asp Ala Ala Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  60
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  60

Cys Ser Pro Asp Ala His Ala Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  61
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  61

Cys Ser Pro Asp Ala His Leu Ala Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  62
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  62

Cys Ser Pro Asp Ala His Leu Gly Cys Ala Ser Tyr Cys 
1               5                   10              


<210>  63
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  63

Cys Ser Pro Asp Ala His Leu Gly Cys Ile Ala Tyr Cys 
1               5                   10              


<210>  64
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  64

Cys Ser Pro Asp Ala His Leu Gly Cys Ile Ser Ala Cys 
1               5                   10              


<210>  65
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is K(N3)

<400>  65

Cys Xaa Pro Asp Ala His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  66
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is K(N3)

<400>  66

Cys Ser Xaa Asp Ala His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


<210>  67
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is K(N3)

<400>  67

Cys Ser Pro Asp Xaa His Leu Gly Cys Ile Ser Tyr Cys 
1               5                   10              


