                         SEQUENCE LISTING

<110>  Glaxosmithkline Biologicals SA
 
<120>  Novel carriers and conjugation methods

<130>  N421966WO

<140>  20207547.9
<141>  2020-11-13

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  824
<212>  PRT
<213>  Streptococcus pyogenes

<400>  1

Met Ser Val Gly Val Ser His Gln Val Lys Ala Asp Asp Arg Ala Ser 
1               5                   10                  15      


Gly Glu Thr Lys Ala Ser Asn Thr His Asp Asp Ser Leu Pro Lys Pro 
            20                  25                  30          


Glu Thr Ile Gln Glu Ala Lys Ala Thr Ile Asp Ala Val Glu Lys Thr 
        35                  40                  45              


Leu Ser Gln Gln Lys Ala Glu Leu Thr Glu Leu Ala Thr Ala Leu Thr 
    50                  55                  60                  


Lys Thr Thr Ala Glu Ile Asn His Leu Lys Glu Gln Gln Asp Asn Glu 
65                  70                  75                  80  


Gln Lys Ala Leu Thr Ser Ala Gln Glu Ile Tyr Thr Asn Thr Leu Ala 
                85                  90                  95      


Ser Ser Glu Glu Thr Leu Leu Ala Gln Gly Ala Glu His Gln Arg Glu 
            100                 105                 110         


Leu Thr Ala Thr Glu Thr Glu Leu His Asn Ala Gln Ala Asp Gln His 
        115                 120                 125             


Ser Lys Glu Thr Ala Leu Ser Glu Gln Lys Ala Ser Ile Ser Ala Glu 
    130                 135                 140                 


Thr Thr Arg Ala Gln Asp Leu Val Glu Gln Val Lys Thr Ser Glu Gln 
145                 150                 155                 160 


Asn Ile Ala Lys Leu Asn Ala Met Ile Ser Asn Pro Asp Ala Ile Thr 
                165                 170                 175     


Lys Ala Ala Gln Thr Ala Asn Asp Asn Thr Lys Ala Leu Ser Ser Glu 
            180                 185                 190         


Leu Glu Lys Ala Lys Ala Asp Leu Glu Asn Gln Lys Ala Lys Val Lys 
        195                 200                 205             


Lys Gln Leu Thr Glu Glu Leu Ala Ala Gln Lys Ala Ala Leu Ala Glu 
    210                 215                 220                 


Lys Glu Ala Glu Leu Ser Arg Leu Lys Ser Ser Ala Pro Ser Thr Gln 
225                 230                 235                 240 


Asp Ser Ile Val Gly Asn Asn Thr Met Lys Ala Pro Gln Gly Tyr Pro 
                245                 250                 255     


Leu Glu Glu Leu Lys Lys Leu Glu Ala Ser Gly Tyr Ile Gly Ser Ala 
            260                 265                 270         


Ser Tyr Asn Asn Tyr Tyr Lys Glu His Ala Asp Gln Ile Ile Ala Lys 
        275                 280                 285             


Ala Ser Pro Gly Asn Gln Leu Asn Gln Tyr Gln Asp Ile Pro Ala Asp 
    290                 295                 300                 


Arg Asn Arg Phe Val Asp Pro Asp Asn Leu Thr Pro Glu Val Gln Asn 
305                 310                 315                 320 


Glu Leu Ala Gln Phe Ala Ala His Met Ile Asn Ser Val Arg Arg Gln 
                325                 330                 335     


Leu Gly Leu Pro Pro Val Thr Val Thr Ala Gly Ser Gln Glu Phe Ala 
            340                 345                 350         


Arg Leu Leu Ser Thr Ser Tyr Lys Lys Thr His Gly Asn Thr Arg Pro 
        355                 360                 365             


Ser Phe Val Tyr Gly Gln Pro Gly Val Ser Gly His Tyr Gly Val Gly 
    370                 375                 380                 


Pro His Asp Lys Thr Ile Ile Glu Asp Ser Ala Gly Ala Ser Gly Leu 
385                 390                 395                 400 


Ile Arg Asn Asp Asp Asn Met Tyr Glu Asn Ile Gly Ala Phe Asn Asp 
                405                 410                 415     


Val His Thr Val Asn Gly Ile Lys Arg Gly Ile Tyr Asp Ser Ile Lys 
            420                 425                 430         


Tyr Met Leu Phe Thr Asp His Leu His Gly Asn Thr Tyr Gly His Ala 
        435                 440                 445             


Ile Asn Phe Leu Arg Val Asp Lys His Asn Pro Asn Ala Pro Val Tyr 
    450                 455                 460                 


Leu Gly Phe Ser Thr Ser Asn Val Gly Ser Leu Asn Glu His Phe Val 
465                 470                 475                 480 


Met Phe Pro Glu Ser Asn Ile Ala Asn His Gln Arg Phe Asn Lys Thr 
                485                 490                 495     


Pro Ile Lys Ala Val Gly Ser Thr Lys Asp Tyr Ala Gln Arg Val Gly 
            500                 505                 510         


Thr Val Ser Asp Thr Ile Ala Ala Ile Lys Gly Lys Val Ser Ser Leu 
        515                 520                 525             


Glu Asn Arg Leu Ser Ala Ile His Gln Glu Ala Asp Ile Met Ala Ala 
    530                 535                 540                 


Gln Ala Lys Val Ser Gln Leu Gln Gly Lys Leu Ala Ser Thr Leu Lys 
545                 550                 555                 560 


Gln Ser Asp Ser Leu Asn Leu Gln Val Arg Gln Leu Asn Asp Thr Lys 
                565                 570                 575     


Gly Ser Leu Arg Thr Glu Leu Leu Ala Ala Lys Ala Lys Gln Ala Gln 
            580                 585                 590         


Leu Glu Ala Thr Arg Asp Gln Ser Leu Ala Lys Leu Ala Ser Leu Lys 
        595                 600                 605             


Ala Ala Leu His Gln Thr Glu Ala Leu Ala Glu Gln Ala Ala Ala Arg 
    610                 615                 620                 


Val Thr Ala Leu Val Ala Lys Lys Ala His Leu Gln Tyr Leu Arg Asp 
625                 630                 635                 640 


Phe Lys Leu Asn Pro Asn Arg Leu Gln Val Ile Arg Glu Arg Ile Asp 
                645                 650                 655     


Asn Thr Lys Gln Asp Leu Ala Lys Thr Thr Ser Ser Leu Leu Asn Ala 
            660                 665                 670         


Gln Glu Ala Leu Ala Ala Leu Gln Ala Lys Gln Ser Ser Leu Glu Ala 
        675                 680                 685             


Thr Ile Ala Thr Thr Glu His Gln Leu Thr Leu Leu Lys Thr Leu Ala 
    690                 695                 700                 


Asn Glu Lys Glu Tyr Arg His Leu Asp Glu Asp Ile Ala Thr Val Pro 
705                 710                 715                 720 


Asp Leu Gln Val Ala Pro Pro Leu Thr Gly Val Lys Pro Leu Ser Tyr 
                725                 730                 735     


Ser Lys Ile Asp Thr Thr Pro Leu Val Gln Glu Met Val Lys Glu Thr 
            740                 745                 750         


Lys Gln Leu Leu Glu Ala Ser Ala Arg Leu Ala Ala Glu Asn Thr Ser 
        755                 760                 765             


Leu Val Ala Glu Ala Leu Val Gly Gln Thr Ser Glu Met Val Ala Ser 
    770                 775                 780                 


Asn Ala Ile Val Ser Lys Ile Thr Ser Ser Ile Thr Gln Pro Ser Ser 
785                 790                 795                 800 


Lys Thr Ser Tyr Gly Ser Gly Ser Ser Thr Thr Ser Asn Leu Ile Ser 
                805                 810                 815     


Asp Val Asp Glu Ser Thr Gln Arg 
            820                 


<210>  2
<211>  873
<212>  PRT
<213>  Streptococcus pyogenes

<400>  2

Met Asp Leu Glu Gln Thr Lys Pro Asn Gln Val Lys Gln Lys Ile Ala 
1               5                   10                  15      


Leu Thr Ser Thr Ile Ala Leu Leu Ser Ala Ser Val Gly Val Ser His 
            20                  25                  30          


Gln Val Lys Ala Asp Asp Arg Ala Ser Gly Glu Thr Lys Ala Ser Asn 
        35                  40                  45              


Thr His Asp Asp Ser Leu Pro Lys Pro Glu Thr Ile Gln Glu Ala Lys 
    50                  55                  60                  


Ala Thr Ile Asp Ala Val Glu Lys Thr Leu Ser Gln Gln Lys Ala Glu 
65                  70                  75                  80  


Leu Thr Glu Leu Ala Thr Ala Leu Thr Lys Thr Thr Ala Glu Ile Asn 
                85                  90                  95      


His Leu Lys Glu Gln Gln Asp Asn Glu Gln Lys Ala Leu Thr Ser Ala 
            100                 105                 110         


Gln Glu Ile Tyr Thr Asn Thr Leu Ala Ser Ser Glu Glu Thr Leu Leu 
        115                 120                 125             


Ala Gln Gly Ala Glu His Gln Arg Glu Leu Thr Ala Thr Glu Thr Glu 
    130                 135                 140                 


Leu His Asn Ala Gln Ala Asp Gln His Ser Lys Glu Thr Ala Leu Ser 
145                 150                 155                 160 


Glu Gln Lys Ala Ser Ile Ser Ala Glu Thr Thr Arg Ala Gln Asp Leu 
                165                 170                 175     


Val Glu Gln Val Lys Thr Ser Glu Gln Asn Ile Ala Lys Leu Asn Ala 
            180                 185                 190         


Met Ile Ser Asn Pro Asp Ala Ile Thr Lys Ala Ala Gln Thr Ala Asn 
        195                 200                 205             


Asp Asn Thr Lys Ala Leu Ser Ser Glu Leu Glu Lys Ala Lys Ala Asp 
    210                 215                 220                 


Leu Glu Asn Gln Lys Ala Lys Val Lys Lys Gln Leu Thr Glu Glu Leu 
225                 230                 235                 240 


Ala Ala Gln Lys Ala Ala Leu Ala Glu Lys Glu Ala Glu Leu Ser Arg 
                245                 250                 255     


Leu Lys Ser Ser Ala Pro Ser Thr Gln Asp Ser Ile Val Gly Asn Asn 
            260                 265                 270         


Thr Met Lys Ala Pro Gln Gly Tyr Pro Leu Glu Glu Leu Lys Lys Leu 
        275                 280                 285             


Glu Ala Ser Gly Tyr Ile Gly Ser Ala Ser Tyr Asn Asn Tyr Tyr Lys 
    290                 295                 300                 


Glu His Ala Asp Gln Ile Ile Ala Lys Ala Ser Pro Gly Asn Gln Leu 
305                 310                 315                 320 


Asn Gln Tyr Gln Asp Ile Pro Ala Asp Arg Asn Arg Phe Val Asp Pro 
                325                 330                 335     


Asp Asn Leu Thr Pro Glu Val Gln Asn Glu Leu Ala Gln Phe Ala Ala 
            340                 345                 350         


His Met Ile Asn Ser Val Arg Arg Gln Leu Gly Leu Pro Pro Val Thr 
        355                 360                 365             


Val Thr Ala Gly Ser Gln Glu Phe Ala Arg Leu Leu Ser Thr Ser Tyr 
    370                 375                 380                 


Lys Lys Thr His Gly Asn Thr Arg Pro Ser Phe Val Tyr Gly Gln Pro 
385                 390                 395                 400 


Gly Val Ser Gly His Tyr Gly Val Gly Pro His Asp Lys Thr Ile Ile 
                405                 410                 415     


Glu Asp Ser Ala Gly Ala Ser Gly Leu Ile Arg Asn Asp Asp Asn Met 
            420                 425                 430         


Tyr Glu Asn Ile Gly Ala Phe Asn Asp Val His Thr Val Asn Gly Ile 
        435                 440                 445             


Lys Arg Gly Ile Tyr Asp Ser Ile Lys Tyr Met Leu Phe Thr Asp His 
    450                 455                 460                 


Leu His Gly Asn Thr Tyr Gly His Ala Ile Asn Phe Leu Arg Val Asp 
465                 470                 475                 480 


Lys His Asn Pro Asn Ala Pro Val Tyr Leu Gly Phe Ser Thr Ser Asn 
                485                 490                 495     


Val Gly Ser Leu Asn Glu His Phe Val Met Phe Pro Glu Ser Asn Ile 
            500                 505                 510         


Ala Asn His Gln Arg Phe Asn Lys Thr Pro Ile Lys Ala Val Gly Ser 
        515                 520                 525             


Thr Lys Asp Tyr Ala Gln Arg Val Gly Thr Val Ser Asp Thr Ile Ala 
    530                 535                 540                 


Ala Ile Lys Gly Lys Val Ser Ser Leu Glu Asn Arg Leu Ser Ala Ile 
545                 550                 555                 560 


His Gln Glu Ala Asp Ile Met Ala Ala Gln Ala Lys Val Ser Gln Leu 
                565                 570                 575     


Gln Gly Lys Leu Ala Ser Thr Leu Lys Gln Ser Asp Ser Leu Asn Leu 
            580                 585                 590         


Gln Val Arg Gln Leu Asn Asp Thr Lys Gly Ser Leu Arg Thr Glu Leu 
        595                 600                 605             


Leu Ala Ala Lys Ala Lys Gln Ala Gln Leu Glu Ala Thr Arg Asp Gln 
    610                 615                 620                 


Ser Leu Ala Lys Leu Ala Ser Leu Lys Ala Ala Leu His Gln Thr Glu 
625                 630                 635                 640 


Ala Leu Ala Glu Gln Ala Ala Ala Arg Val Thr Ala Leu Val Ala Lys 
                645                 650                 655     


Lys Ala His Leu Gln Tyr Leu Arg Asp Phe Lys Leu Asn Pro Asn Arg 
            660                 665                 670         


Leu Gln Val Ile Arg Glu Arg Ile Asp Asn Thr Lys Gln Asp Leu Ala 
        675                 680                 685             


Lys Thr Thr Ser Ser Leu Leu Asn Ala Gln Glu Ala Leu Ala Ala Leu 
    690                 695                 700                 


Gln Ala Lys Gln Ser Ser Leu Glu Ala Thr Ile Ala Thr Thr Glu His 
705                 710                 715                 720 


Gln Leu Thr Leu Leu Lys Thr Leu Ala Asn Glu Lys Glu Tyr Arg His 
                725                 730                 735     


Leu Asp Glu Asp Ile Ala Thr Val Pro Asp Leu Gln Val Ala Pro Pro 
            740                 745                 750         


Leu Thr Gly Val Lys Pro Leu Ser Tyr Ser Lys Ile Asp Thr Thr Pro 
        755                 760                 765             


Leu Val Gln Glu Met Val Lys Glu Thr Lys Gln Leu Leu Glu Ala Ser 
    770                 775                 780                 


Ala Arg Leu Ala Ala Glu Asn Thr Ser Leu Val Ala Glu Ala Leu Val 
785                 790                 795                 800 


Gly Gln Thr Ser Glu Met Val Ala Ser Asn Ala Ile Val Ser Lys Ile 
                805                 810                 815     


Thr Ser Ser Ile Thr Gln Pro Ser Ser Lys Thr Ser Tyr Gly Ser Gly 
            820                 825                 830         


Ser Ser Thr Thr Ser Asn Leu Ile Ser Asp Val Asp Glu Ser Thr Gln 
        835                 840                 845             


Arg Ala Leu Lys Ala Gly Val Val Met Leu Ala Ala Val Gly Leu Thr 
    850                 855                 860                 


Gly Phe Arg Phe Arg Lys Glu Ser Lys 
865                 870             


<210>  3
<211>  1581
<212>  PRT
<213>  Streptococcus pyogenes

<400>  3

Met Ala Asp Glu Leu Ser Thr Met Ser Glu Pro Thr Ile Thr Asn His 
1               5                   10                  15      


Ala Gln Gln Gln Ala Gln His Leu Thr Asn Thr Glu Leu Ser Ser Ala 
            20                  25                  30          


Glu Ser Lys Ser Gln Asp Thr Ser Gln Ile Thr Leu Lys Thr Asn Arg 
        35                  40                  45              


Glu Lys Glu Gln Ser Gln Asp Leu Val Ser Glu Pro Thr Thr Thr Glu 
    50                  55                  60                  


Leu Ala Asp Thr Asp Ala Ala Ser Met Ala Asn Thr Gly Ser Asp Ala 
65                  70                  75                  80  


Thr Gln Lys Ser Ala Ser Leu Pro Pro Val Asn Thr Asp Val His Asp 
                85                  90                  95      


Trp Val Lys Thr Lys Gly Ala Trp Asp Lys Gly Tyr Lys Gly Gln Gly 
            100                 105                 110         


Lys Val Val Ala Val Ile Ala Thr Gly Ile Asp Pro Ala His Gln Ser 
        115                 120                 125             


Met Arg Ile Ser Asp Val Ser Thr Ala Lys Val Lys Ser Lys Glu Asp 
    130                 135                 140                 


Met Leu Ala Arg Gln Lys Ala Ala Gly Ile Asn Tyr Gly Ser Trp Ile 
145                 150                 155                 160 


Asn Asp Lys Val Val Phe Ala His Asn Tyr Val Glu Asn Ser Asp Asn 
                165                 170                 175     


Ile Lys Glu Asn Gln Phe Glu Asp Phe Asp Glu Asp Trp Glu Asn Phe 
            180                 185                 190         


Glu Phe Asp Ala Glu Ala Glu Pro Lys Ala Ile Lys Lys His Lys Ile 
        195                 200                 205             


Tyr Arg Pro Gln Ser Thr Gln Ala Pro Lys Glu Thr Val Ile Lys Thr 
    210                 215                 220                 


Glu Glu Thr Asp Gly Ser His Asp Ile Asp Trp Thr Gln Thr Asp Asp 
225                 230                 235                 240 


Asp Thr Lys Tyr Glu Ser His Gly Met His Val Thr Gly Ile Val Ala 
                245                 250                 255     


Gly Asn Ser Lys Glu Ala Ala Ala Thr Gly Glu Arg Phe Leu Gly Ile 
            260                 265                 270         


Ala Pro Glu Ala Gln Val Met Phe Met Arg Val Phe Ala Asn Asp Ile 
        275                 280                 285             


Met Gly Ser Ala Glu Ser Leu Phe Ile Lys Ala Ile Glu Asp Ala Val 
    290                 295                 300                 


Ala Leu Gly Ala Asp Val Ile Asn Leu Ser Leu Gly Thr Ala Asn Gly 
305                 310                 315                 320 


Ala Gln Leu Ser Gly Ser Lys Pro Leu Met Glu Ala Ile Glu Lys Ala 
                325                 330                 335     


Lys Lys Ala Gly Val Ser Val Val Val Ala Ala Gly Asn Glu Arg Val 
            340                 345                 350         


Tyr Gly Ser Asp His Asp Asp Pro Leu Ala Thr Asn Pro Asp Tyr Gly 
        355                 360                 365             


Leu Val Gly Ser Pro Ser Thr Gly Arg Thr Pro Thr Ser Val Ala Ala 
    370                 375                 380                 


Ile Asn Ser Lys Trp Val Ile Gln Arg Leu Met Thr Val Lys Glu Leu 
385                 390                 395                 400 


Glu Asn Arg Ala Asp Leu Asn His Gly Lys Ala Ile Tyr Ser Glu Ser 
                405                 410                 415     


Val Asp Phe Lys Asp Ile Lys Asp Ser Leu Gly Tyr Asp Lys Ser His 
            420                 425                 430         


Gln Phe Ala Tyr Val Lys Glu Ser Thr Asp Ala Gly Tyr Asn Ala Gln 
        435                 440                 445             


Asp Val Lys Gly Lys Ile Ala Leu Ile Glu Arg Asp Pro Asn Lys Thr 
    450                 455                 460                 


Tyr Asp Glu Met Ile Ala Leu Ala Lys Lys His Gly Ala Leu Gly Val 
465                 470                 475                 480 


Leu Ile Phe Asn Asn Lys Pro Gly Gln Ser Asn Arg Ser Met Arg Leu 
                485                 490                 495     


Thr Ala Asn Gly Met Gly Ile Pro Ser Ala Phe Ile Ser His Glu Phe 
            500                 505                 510         


Gly Lys Ala Met Ser Gln Leu Asn Gly Asn Gly Thr Gly Ser Leu Glu 
        515                 520                 525             


Phe Asp Ser Val Val Ser Lys Ala Pro Ser Gln Lys Gly Asn Glu Met 
    530                 535                 540                 


Asn His Phe Ser Asn Trp Gly Leu Thr Ser Asp Gly Tyr Leu Lys Pro 
545                 550                 555                 560 


Asp Ile Thr Ala Pro Gly Gly Asp Ile Tyr Ser Thr Tyr Asn Asp Asn 
                565                 570                 575     


His Tyr Gly Ser Gln Thr Gly Thr Ala Met Ala Ser Pro Gln Ile Ala 
            580                 585                 590         


Gly Ala Ser Leu Leu Val Lys Gln Tyr Leu Glu Lys Thr Gln Pro Asn 
        595                 600                 605             


Leu Pro Lys Glu Lys Ile Ala Asp Ile Val Lys Asn Leu Leu Met Ser 
    610                 615                 620                 


Asn Ala Gln Ile His Val Asn Pro Glu Thr Lys Thr Thr Thr Ser Pro 
625                 630                 635                 640 


Arg Gln Gln Gly Ala Gly Leu Leu Asn Ile Asp Gly Ala Val Thr Ser 
                645                 650                 655     


Gly Leu Tyr Val Thr Gly Lys Asp Asn Tyr Gly Ser Ile Ser Leu Gly 
            660                 665                 670         


Asn Ile Thr Asp Thr Met Thr Phe Asp Val Thr Val His Asn Leu Ser 
        675                 680                 685             


Asn Lys Asp Lys Thr Leu Arg Tyr Asp Thr Glu Leu Leu Thr Asp His 
    690                 695                 700                 


Val Asp Pro Gln Lys Gly Arg Phe Thr Leu Thr Ser His Ser Leu Lys 
705                 710                 715                 720 


Thr Tyr Gln Gly Gly Glu Val Thr Val Pro Ala Asn Gly Lys Val Thr 
                725                 730                 735     


Val Arg Val Thr Met Asp Val Ser Gln Phe Thr Lys Glu Leu Thr Lys 
            740                 745                 750         


Gln Met Pro Asn Gly Tyr Tyr Leu Glu Gly Phe Val Arg Phe Arg Asp 
        755                 760                 765             


Ser Gln Asp Asp Gln Leu Asn Arg Val Asn Ile Pro Phe Val Gly Phe 
    770                 775                 780                 


Lys Gly Gln Phe Glu Asn Leu Ala Val Ala Glu Glu Ser Ile Tyr Arg 
785                 790                 795                 800 


Leu Lys Ser Gln Gly Lys Thr Gly Phe Tyr Phe Asp Glu Ser Gly Pro 
                805                 810                 815     


Lys Asp Asp Ile Tyr Val Gly Lys His Phe Thr Gly Leu Val Thr Leu 
            820                 825                 830         


Gly Ser Glu Thr Asn Val Ser Thr Lys Thr Ile Ser Asp Asn Gly Leu 
        835                 840                 845             


His Thr Leu Gly Thr Phe Lys Asn Ala Asp Gly Lys Phe Ile Leu Glu 
    850                 855                 860                 


Lys Asn Ala Gln Gly Asn Pro Val Leu Ala Ile Ser Pro Asn Gly Asp 
865                 870                 875                 880 


Asn Asn Gln Asp Phe Ala Ala Phe Lys Gly Val Phe Leu Arg Lys Tyr 
                885                 890                 895     


Gln Gly Leu Lys Ala Ser Val Tyr His Ala Ser Asp Lys Glu His Lys 
            900                 905                 910         


Asn Pro Leu Trp Val Ser Pro Glu Ser Phe Lys Gly Asp Lys Asn Phe 
        915                 920                 925             


Asn Ser Asp Ile Arg Phe Ala Lys Ser Thr Thr Leu Leu Gly Thr Ala 
    930                 935                 940                 


Phe Ser Gly Lys Ser Leu Thr Gly Ala Glu Leu Pro Asp Gly His Tyr 
945                 950                 955                 960 


His Tyr Val Val Ser Tyr Tyr Pro Asp Val Val Gly Ala Lys Arg Gln 
                965                 970                 975     


Glu Met Thr Phe Asp Met Ile Leu Asp Arg Gln Lys Pro Val Leu Ser 
            980                 985                 990         


Gln Ala Thr Phe Asp Pro Glu Thr  Asn Arg Phe Lys Pro  Glu Pro Leu 
        995                 1000                 1005             


Lys Asp  Arg Gly Leu Ala Gly  Val Arg Lys Asp Ser  Val Phe Tyr 
    1010                 1015                 1020             


Leu Glu  Arg Lys Asp Asn Lys  Pro Tyr Thr Val Thr  Ile Asn Asp 
    1025                 1030                 1035             


Ser Tyr  Lys Tyr Val Ser Val  Glu Asp Asn Lys Thr  Phe Val Glu 
    1040                 1045                 1050             


Arg Gln  Ala Asp Gly Ser Phe  Ile Leu Pro Leu Asp  Lys Ala Lys 
    1055                 1060                 1065             


Leu Gly  Asp Phe Tyr Tyr Met  Val Glu Asp Phe Ala  Gly Asn Val 
    1070                 1075                 1080             


Ala Ile  Ala Lys Leu Gly Asp  His Leu Pro Gln Thr  Leu Gly Lys 
    1085                 1090                 1095             


Thr Pro  Ile Lys Leu Lys Leu  Thr Asp Gly Asn Tyr  Gln Thr Lys 
    1100                 1105                 1110             


Glu Thr  Leu Lys Asp Asn Leu  Glu Met Thr Gln Ser  Asp Thr Gly 
    1115                 1120                 1125             


Leu Val  Thr Asn Gln Ala Gln  Leu Ala Val Val His  Arg Asn Gln 
    1130                 1135                 1140             


Pro Gln  Ser Gln Leu Thr Lys  Met Asn Gln Asp Phe  Phe Ile Ser 
    1145                 1150                 1155             


Pro Asn  Glu Asp Gly Asn Lys  Asp Phe Val Ala Phe  Lys Gly Leu 
    1160                 1165                 1170             


Lys Asn  Asn Val Tyr Asn Asp  Leu Thr Val Asn Val  Tyr Ala Lys 
    1175                 1180                 1185             


Asp Asp  His Gln Lys Gln Thr  Pro Ile Trp Ser Ser  Gln Ala Gly 
    1190                 1195                 1200             


Ala Ser  Val Ser Ala Ile Glu  Ser Thr Ala Trp Tyr  Gly Ile Thr 
    1205                 1210                 1215             


Ala Arg  Gly Ser Lys Val Met  Pro Gly Asp Tyr Gln  Tyr Val Val 
    1220                 1225                 1230             


Thr Tyr  Arg Asp Glu His Gly  Lys Glu His Gln Lys  Gln Tyr Thr 
    1235                 1240                 1245             


Ile Ser  Val Asn Asp Lys Lys  Pro Met Ile Thr Gln  Gly Arg Phe 
    1250                 1255                 1260             


Asp Thr  Ile Asn Gly Val Asp  His Phe Thr Pro Asp  Lys Thr Lys 
    1265                 1270                 1275             


Ala Leu  Asp Ser Ser Gly Ile  Val Arg Glu Glu Val  Phe Tyr Leu 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Arg Lys  Phe Asp Val Thr Glu  Gly Lys Asp 
    1295                 1300                 1305             


Gly Ile  Thr Val Ser Asp Asn  Lys Val Tyr Ile Pro  Lys Asn Pro 
    1310                 1315                 1320             


Asp Gly  Ser Tyr Thr Ile Ser  Lys Arg Asp Gly Val  Thr Leu Ser 
    1325                 1330                 1335             


Asp Tyr  Tyr Tyr Leu Val Glu  Asp Arg Ala Gly Asn  Val Ser Phe 
    1340                 1345                 1350             


Ala Thr  Leu Arg Asp Leu Lys  Ala Val Gly Lys Asp  Lys Ala Val 
    1355                 1360                 1365             


Val Asn  Phe Gly Leu Asp Leu  Pro Val Pro Glu Asp  Lys Gln Ile 
    1370                 1375                 1380             


Val Asn  Phe Thr Tyr Leu Val  Arg Asp Ala Asp Gly  Lys Pro Ile 
    1385                 1390                 1395             


Glu Asn  Leu Glu Tyr Tyr Asn  Asn Ser Gly Asn Ser  Leu Ile Leu 
    1400                 1405                 1410             


Pro Tyr  Gly Lys Tyr Thr Val  Glu Leu Leu Thr Tyr  Asp Thr Asn 
    1415                 1420                 1425             


Ala Ala  Lys Leu Glu Ser Asp  Lys Ile Val Ser Phe  Thr Leu Ser 
    1430                 1435                 1440             


Ala Asp  Asn Asn Phe Gln Gln  Val Thr Phe Lys Ile  Thr Met Leu 
    1445                 1450                 1455             


Ala Thr  Ser Gln Ile Thr Ala  His Phe Asp His Leu  Leu Pro Glu 
    1460                 1465                 1470             


Gly Ser  Arg Val Ser Leu Lys  Thr Ala Gln Asp Gln  Leu Ile Pro 
    1475                 1480                 1485             


Leu Glu  Gln Ser Leu Tyr Val  Pro Lys Ala Tyr Gly  Lys Thr Val 
    1490                 1495                 1500             


Gln Glu  Gly Thr Tyr Glu Val  Val Val Ser Leu Pro  Lys Gly Tyr 
    1505                 1510                 1515             


Arg Ile  Glu Gly Asn Thr Lys  Val Asn Thr Leu Pro  Asn Glu Val 
    1520                 1525                 1530             


His Glu  Leu Ser Leu Arg Leu  Val Lys Val Gly Asp  Ala Ser Asp 
    1535                 1540                 1545             


Ser Thr  Gly Asp His Lys Val  Met Ser Lys Asn Asn  Ser Gln Ala 
    1550                 1555                 1560             


Leu Thr  Ala Ser Ala Thr Pro  Thr Lys Ser Thr Thr  Ser Ala Thr 
    1565                 1570                 1575             


Ala Lys  Ala 
    1580     


<210>  4
<211>  1647
<212>  PRT
<213>  Streptococcus pyogenes

<400>  4

Met Glu Lys Lys Gln Arg Phe Ser Leu Arg Lys Tyr Lys Ser Gly Thr 
1               5                   10                  15      


Phe Ser Val Leu Ile Gly Ser Val Phe Leu Val Met Thr Thr Thr Val 
            20                  25                  30          


Ala Ala Asp Glu Leu Ser Thr Met Ser Glu Pro Thr Ile Thr Asn His 
        35                  40                  45              


Ala Gln Gln Gln Ala Gln His Leu Thr Asn Thr Glu Leu Ser Ser Ala 
    50                  55                  60                  


Glu Ser Lys Ser Gln Asp Thr Ser Gln Ile Thr Leu Lys Thr Asn Arg 
65                  70                  75                  80  


Glu Lys Glu Gln Ser Gln Asp Leu Val Ser Glu Pro Thr Thr Thr Glu 
                85                  90                  95      


Leu Ala Asp Thr Asp Ala Ala Ser Met Ala Asn Thr Gly Ser Asp Ala 
            100                 105                 110         


Thr Gln Lys Ser Ala Ser Leu Pro Pro Val Asn Thr Asp Val His Asp 
        115                 120                 125             


Trp Val Lys Thr Lys Gly Ala Trp Asp Lys Gly Tyr Lys Gly Gln Gly 
    130                 135                 140                 


Lys Val Val Ala Val Ile Asp Thr Gly Ile Asp Pro Ala His Gln Ser 
145                 150                 155                 160 


Met Arg Ile Ser Asp Val Ser Thr Ala Lys Val Lys Ser Lys Glu Asp 
                165                 170                 175     


Met Leu Ala Arg Gln Lys Ala Ala Gly Ile Asn Tyr Gly Ser Trp Ile 
            180                 185                 190         


Asn Asp Lys Val Val Phe Ala His Asn Tyr Val Glu Asn Ser Asp Asn 
        195                 200                 205             


Ile Lys Glu Asn Gln Phe Glu Asp Phe Asp Glu Asp Trp Glu Asn Phe 
    210                 215                 220                 


Glu Phe Asp Ala Glu Ala Glu Pro Lys Ala Ile Lys Lys His Lys Ile 
225                 230                 235                 240 


Tyr Arg Pro Gln Ser Thr Gln Ala Pro Lys Glu Thr Val Ile Lys Thr 
                245                 250                 255     


Glu Glu Thr Asp Gly Ser His Asp Ile Asp Trp Thr Gln Thr Asp Asp 
            260                 265                 270         


Asp Thr Lys Tyr Glu Ser His Gly Met His Val Thr Gly Ile Val Ala 
        275                 280                 285             


Gly Asn Ser Lys Glu Ala Ala Ala Thr Gly Glu Arg Phe Leu Gly Ile 
    290                 295                 300                 


Ala Pro Glu Ala Gln Val Met Phe Met Arg Val Phe Ala Asn Asp Ile 
305                 310                 315                 320 


Met Gly Ser Ala Glu Ser Leu Phe Ile Lys Ala Ile Glu Asp Ala Val 
                325                 330                 335     


Ala Leu Gly Ala Asp Val Ile Asn Leu Ser Leu Gly Thr Ala Asn Gly 
            340                 345                 350         


Ala Gln Leu Ser Gly Ser Lys Pro Leu Met Glu Ala Ile Glu Lys Ala 
        355                 360                 365             


Lys Lys Ala Gly Val Ser Val Val Val Ala Ala Gly Asn Glu Arg Val 
    370                 375                 380                 


Tyr Gly Ser Asp His Asp Asp Pro Leu Ala Thr Asn Pro Asp Tyr Gly 
385                 390                 395                 400 


Leu Val Gly Ser Pro Ser Thr Gly Arg Thr Pro Thr Ser Val Ala Ala 
                405                 410                 415     


Ile Asn Ser Lys Trp Val Ile Gln Arg Leu Met Thr Val Lys Glu Leu 
            420                 425                 430         


Glu Asn Arg Ala Asp Leu Asn His Gly Lys Ala Ile Tyr Ser Glu Ser 
        435                 440                 445             


Val Asp Phe Lys Asp Ile Lys Asp Ser Leu Gly Tyr Asp Lys Ser His 
    450                 455                 460                 


Gln Phe Ala Tyr Val Lys Glu Ser Thr Asp Ala Gly Tyr Asn Ala Gln 
465                 470                 475                 480 


Asp Val Lys Gly Lys Ile Ala Leu Ile Glu Arg Asp Pro Asn Lys Thr 
                485                 490                 495     


Tyr Asp Glu Met Ile Ala Leu Ala Lys Lys His Gly Ala Leu Gly Val 
            500                 505                 510         


Leu Ile Phe Asn Asn Lys Pro Gly Gln Ser Asn Arg Ser Met Arg Leu 
        515                 520                 525             


Thr Ala Asn Gly Met Gly Ile Pro Ser Ala Phe Ile Ser His Glu Phe 
    530                 535                 540                 


Gly Lys Ala Met Ser Gln Leu Asn Gly Asn Gly Thr Gly Ser Leu Glu 
545                 550                 555                 560 


Phe Asp Ser Val Val Ser Lys Ala Pro Ser Gln Lys Gly Asn Glu Met 
                565                 570                 575     


Asn His Phe Ser Asn Trp Gly Leu Thr Ser Asp Gly Tyr Leu Lys Pro 
            580                 585                 590         


Asp Ile Thr Ala Pro Gly Gly Asp Ile Tyr Ser Thr Tyr Asn Asp Asn 
        595                 600                 605             


His Tyr Gly Ser Gln Thr Gly Thr Ser Met Ala Ser Pro Gln Ile Ala 
    610                 615                 620                 


Gly Ala Ser Leu Leu Val Lys Gln Tyr Leu Glu Lys Thr Gln Pro Asn 
625                 630                 635                 640 


Leu Pro Lys Glu Lys Ile Ala Asp Ile Val Lys Asn Leu Leu Met Ser 
                645                 650                 655     


Asn Ala Gln Ile His Val Asn Pro Glu Thr Lys Thr Thr Thr Ser Pro 
            660                 665                 670         


Arg Gln Gln Gly Ala Gly Leu Leu Asn Ile Asp Gly Ala Val Thr Ser 
        675                 680                 685             


Gly Leu Tyr Val Thr Gly Lys Asp Asn Tyr Gly Ser Ile Ser Leu Gly 
    690                 695                 700                 


Asn Ile Thr Asp Thr Met Thr Phe Asp Val Thr Val His Asn Leu Ser 
705                 710                 715                 720 


Asn Lys Asp Lys Thr Leu Arg Tyr Asp Thr Glu Leu Leu Thr Asp His 
                725                 730                 735     


Val Asp Pro Gln Lys Gly Arg Phe Thr Leu Thr Ser His Ser Leu Lys 
            740                 745                 750         


Thr Tyr Gln Gly Gly Glu Val Thr Val Pro Ala Asn Gly Lys Val Thr 
        755                 760                 765             


Val Arg Val Thr Met Asp Val Ser Gln Phe Thr Lys Glu Leu Thr Lys 
    770                 775                 780                 


Gln Met Pro Asn Gly Tyr Tyr Leu Glu Gly Phe Val Arg Phe Arg Asp 
785                 790                 795                 800 


Ser Gln Asp Asp Gln Leu Asn Arg Val Asn Ile Pro Phe Val Gly Phe 
                805                 810                 815     


Lys Gly Gln Phe Glu Asn Leu Ala Val Ala Glu Glu Ser Ile Tyr Arg 
            820                 825                 830         


Leu Lys Ser Gln Gly Lys Thr Gly Phe Tyr Phe Asp Glu Ser Gly Pro 
        835                 840                 845             


Lys Asp Asp Ile Tyr Val Gly Lys His Phe Thr Gly Leu Val Thr Leu 
    850                 855                 860                 


Gly Ser Glu Thr Asn Val Ser Thr Lys Thr Ile Ser Asp Asn Gly Leu 
865                 870                 875                 880 


His Thr Leu Gly Thr Phe Lys Asn Ala Asp Gly Lys Phe Ile Leu Glu 
                885                 890                 895     


Lys Asn Ala Gln Gly Asn Pro Val Leu Ala Ile Ser Pro Asn Gly Asp 
            900                 905                 910         


Asn Asn Gln Asp Phe Ala Ala Phe Lys Gly Val Phe Leu Arg Lys Tyr 
        915                 920                 925             


Gln Gly Leu Lys Ala Ser Val Tyr His Ala Ser Asp Lys Glu His Lys 
    930                 935                 940                 


Asn Pro Leu Trp Val Ser Pro Glu Ser Phe Lys Gly Asp Lys Asn Phe 
945                 950                 955                 960 


Asn Ser Asp Ile Arg Phe Ala Lys Ser Thr Thr Leu Leu Gly Thr Ala 
                965                 970                 975     


Phe Ser Gly Lys Ser Leu Thr Gly Ala Glu Leu Pro Asp Gly His Tyr 
            980                 985                 990         


His Tyr Val Val Ser Tyr Tyr Pro  Asp Val Val Gly Ala  Lys Arg Gln 
        995                 1000                 1005             


Glu Met  Thr Phe Asp Met Ile  Leu Asp Arg Gln Lys  Pro Val Leu 
    1010                 1015                 1020             


Ser Gln  Ala Thr Phe Asp Pro  Glu Thr Asn Arg Phe  Lys Pro Glu 
    1025                 1030                 1035             


Pro Leu  Lys Asp Arg Gly Leu  Ala Gly Val Arg Lys  Asp Ser Val 
    1040                 1045                 1050             


Phe Tyr  Leu Glu Arg Lys Asp  Asn Lys Pro Tyr Thr  Val Thr Ile 
    1055                 1060                 1065             


Asn Asp  Ser Tyr Lys Tyr Val  Ser Val Glu Asp Asn  Lys Thr Phe 
    1070                 1075                 1080             


Val Glu  Arg Gln Ala Asp Gly  Ser Phe Ile Leu Pro  Leu Asp Lys 
    1085                 1090                 1095             


Ala Lys  Leu Gly Asp Phe Tyr  Tyr Met Val Glu Asp  Phe Ala Gly 
    1100                 1105                 1110             


Asn Val  Ala Ile Ala Lys Leu  Gly Asp His Leu Pro  Gln Thr Leu 
    1115                 1120                 1125             


Gly Lys  Thr Pro Ile Lys Leu  Lys Leu Thr Asp Gly  Asn Tyr Gln 
    1130                 1135                 1140             


Thr Lys  Glu Thr Leu Lys Asp  Asn Leu Glu Met Thr  Gln Ser Asp 
    1145                 1150                 1155             


Thr Gly  Leu Val Thr Asn Gln  Ala Gln Leu Ala Val  Val His Arg 
    1160                 1165                 1170             


Asn Gln  Pro Gln Ser Gln Leu  Thr Lys Met Asn Gln  Asp Phe Phe 
    1175                 1180                 1185             


Ile Ser  Pro Asn Glu Asp Gly  Asn Lys Asp Phe Val  Ala Phe Lys 
    1190                 1195                 1200             


Gly Leu  Lys Asn Asn Val Tyr  Asn Asp Leu Thr Val  Asn Val Tyr 
    1205                 1210                 1215             


Ala Lys  Asp Asp His Gln Lys  Gln Thr Pro Ile Trp  Ser Ser Gln 
    1220                 1225                 1230             


Ala Gly  Ala Ser Val Ser Ala  Ile Glu Ser Thr Ala  Trp Tyr Gly 
    1235                 1240                 1245             


Ile Thr  Ala Arg Gly Ser Lys  Val Met Pro Gly Asp  Tyr Gln Tyr 
    1250                 1255                 1260             


Val Val  Thr Tyr Arg Asp Glu  His Gly Lys Glu His  Gln Lys Gln 
    1265                 1270                 1275             


Tyr Thr  Ile Ser Val Asn Asp  Lys Lys Pro Met Ile  Thr Gln Gly 
    1280                 1285                 1290             


Arg Phe  Asp Thr Ile Asn Gly  Val Asp His Phe Thr  Pro Asp Lys 
    1295                 1300                 1305             


Thr Lys  Ala Leu Asp Ser Ser  Gly Ile Val Arg Glu  Glu Val Phe 
    1310                 1315                 1320             


Tyr Leu  Ala Lys Lys Asn Gly  Arg Lys Phe Asp Val  Thr Glu Gly 
    1325                 1330                 1335             


Lys Asp  Gly Ile Thr Val Ser  Asp Asn Lys Val Tyr  Ile Pro Lys 
    1340                 1345                 1350             


Asn Pro  Asp Gly Ser Tyr Thr  Ile Ser Lys Arg Asp  Gly Val Thr 
    1355                 1360                 1365             


Leu Ser  Asp Tyr Tyr Tyr Leu  Val Glu Asp Arg Ala  Gly Asn Val 
    1370                 1375                 1380             


Ser Phe  Ala Thr Leu Arg Asp  Leu Lys Ala Val Gly  Lys Asp Lys 
    1385                 1390                 1395             


Ala Val  Val Asn Phe Gly Leu  Asp Leu Pro Val Pro  Glu Asp Lys 
    1400                 1405                 1410             


Gln Ile  Val Asn Phe Thr Tyr  Leu Val Arg Asp Ala  Asp Gly Lys 
    1415                 1420                 1425             


Pro Ile  Glu Asn Leu Glu Tyr  Tyr Asn Asn Ser Gly  Asn Ser Leu 
    1430                 1435                 1440             


Ile Leu  Pro Tyr Gly Lys Tyr  Thr Val Glu Leu Leu  Thr Tyr Asp 
    1445                 1450                 1455             


Thr Asn  Ala Ala Lys Leu Glu  Ser Asp Lys Ile Val  Ser Phe Thr 
    1460                 1465                 1470             


Leu Ser  Ala Asp Asn Asn Phe  Gln Gln Val Thr Phe  Lys Ile Thr 
    1475                 1480                 1485             


Met Leu  Ala Thr Ser Gln Ile  Thr Ala His Phe Asp  His Leu Leu 
    1490                 1495                 1500             


Pro Glu  Gly Ser Arg Val Ser  Leu Lys Thr Ala Gln  Asp Gln Leu 
    1505                 1510                 1515             


Ile Pro  Leu Glu Gln Ser Leu  Tyr Val Pro Lys Ala  Tyr Gly Lys 
    1520                 1525                 1530             


Thr Val  Gln Glu Gly Thr Tyr  Glu Val Val Val Ser  Leu Pro Lys 
    1535                 1540                 1545             


Gly Tyr  Arg Ile Glu Gly Asn  Thr Lys Val Asn Thr  Leu Pro Asn 
    1550                 1555                 1560             


Glu Val  His Glu Leu Ser Leu  Arg Leu Val Lys Val  Gly Asp Ala 
    1565                 1570                 1575             


Ser Asp  Ser Thr Gly Asp His  Lys Val Met Ser Lys  Asn Asn Ser 
    1580                 1585                 1590             


Gln Ala  Leu Thr Ala Ser Ala  Thr Pro Thr Lys Ser  Thr Thr Ser 
    1595                 1600                 1605             


Ala Thr  Ala Lys Ala Leu Pro  Ser Thr Gly Glu Lys  Met Gly Leu 
    1610                 1615                 1620             


Lys Leu  Arg Ile Val Gly Leu  Val Leu Leu Gly Leu  Thr Cys Val 
    1625                 1630                 1635             


Phe Ser  Arg Lys Lys Ser Thr  Lys Asp 
    1640                 1645         


<210>  5
<211>  543
<212>  PRT
<213>  Streptococcus pyogenes

<400>  5

Met Ala Ser Glu Ser Asn Lys Gln Asn Thr Ala Ser Thr Glu Thr Thr 
1               5                   10                  15      


Thr Thr Asn Glu Gln Pro Lys Pro Glu Ser Ser Glu Leu Thr Thr Glu 
            20                  25                  30          


Lys Ala Gly Gln Lys Thr Asp Asp Met Leu Asn Ser Asn Asp Met Ile 
        35                  40                  45              


Lys Leu Ala Pro Lys Glu Met Pro Leu Glu Ser Ala Glu Lys Glu Glu 
    50                  55                  60                  


Lys Lys Ser Glu Asp Lys Lys Lys Ser Glu Glu Asp His Thr Glu Glu 
65                  70                  75                  80  


Ile Asn Asp Lys Ile Tyr Ser Leu Asn Tyr Asn Glu Leu Glu Val Leu 
                85                  90                  95      


Ala Lys Asn Gly Glu Thr Ile Glu Asn Phe Val Pro Lys Glu Gly Val 
            100                 105                 110         


Lys Lys Ala Asp Lys Phe Ile Val Ile Glu Arg Lys Lys Lys Asn Ile 
        115                 120                 125             


Asn Thr Thr Pro Val Asp Ile Ser Ile Ile Asp Ser Val Thr Asp Arg 
    130                 135                 140                 


Thr Tyr Pro Ala Ala Leu Gln Leu Ala Asn Lys Gly Phe Thr Glu Asn 
145                 150                 155                 160 


Lys Pro Asp Ala Val Val Thr Lys Arg Asn Pro Gln Lys Ile His Ile 
                165                 170                 175     


Asp Leu Pro Gly Met Gly Asp Lys Ala Thr Val Glu Val Asn Asp Pro 
            180                 185                 190         


Thr Tyr Ala Asn Val Ser Thr Ala Ile Asp Asn Leu Val Asn Gln Trp 
        195                 200                 205             


His Asp Asn Tyr Ser Gly Gly Asn Thr Leu Pro Ala Arg Thr Gln Tyr 
    210                 215                 220                 


Thr Glu Ser Met Val Tyr Ser Lys Ser Gln Ile Glu Ala Ala Leu Asn 
225                 230                 235                 240 


Val Asn Ser Lys Ile Leu Asp Gly Thr Leu Gly Ile Asp Phe Lys Ser 
                245                 250                 255     


Ile Ser Lys Gly Glu Lys Lys Val Met Ile Ala Ala Tyr Lys Gln Ile 
            260                 265                 270         


Phe Tyr Thr Val Ser Ala Asn Leu Pro Asn Asn Pro Ala Asp Val Phe 
        275                 280                 285             


Asp Lys Ser Val Thr Phe Lys Glu Leu Gln Arg Lys Gly Val Ser Asn 
    290                 295                 300                 


Glu Ala Pro Pro Leu Phe Val Ser Asn Val Ala Tyr Gly Arg Thr Val 
305                 310                 315                 320 


Phe Val Lys Leu Glu Thr Ser Ser Lys Ser Asn Asp Val Glu Ala Ala 
                325                 330                 335     


Phe Ser Ala Ala Leu Lys Gly Thr Asp Val Lys Thr Asn Gly Lys Tyr 
            340                 345                 350         


Ser Asp Ile Leu Glu Asn Ser Ser Phe Thr Ala Val Val Leu Gly Gly 
        355                 360                 365             


Asp Ala Ala Glu His Asn Lys Val Val Thr Lys Asp Phe Asp Val Ile 
    370                 375                 380                 


Arg Asn Val Ile Lys Asp Asn Ala Thr Phe Ser Arg Lys Asn Leu Ala 
385                 390                 395                 400 


Tyr Pro Ile Ser Tyr Thr Ser Val Phe Leu Lys Asn Asn Lys Ile Ala 
                405                 410                 415     


Gly Val Asn Asn Arg Thr Glu Tyr Val Glu Thr Thr Ser Thr Glu Tyr 
            420                 425                 430         


Thr Ser Gly Lys Ile Asn Leu Ser His Gln Gly Ala Tyr Val Ala Gln 
        435                 440                 445             


Tyr Glu Ile Leu Trp Asp Glu Ile Asn Tyr Asp Asp Lys Gly Lys Glu 
    450                 455                 460                 


Val Ile Thr Lys Arg Arg Trp Asp Asn Asn Trp Tyr Ser Lys Thr Ser 
465                 470                 475                 480 


Pro Phe Ser Thr Val Ile Pro Leu Gly Ala Asn Ser Arg Asn Ile Arg 
                485                 490                 495     


Ile Met Ala Arg Glu Cys Thr Gly Leu Ala Phe Glu Trp Trp Arg Lys 
            500                 505                 510         


Val Ile Asp Glu Arg Asp Val Lys Leu Ser Lys Glu Ile Asn Val Asn 
        515                 520                 525             


Ile Ser Gly Ser Thr Leu Ser Pro Tyr Gly Ser Ile Thr Tyr Lys 
    530                 535                 540             


<210>  6
<211>  571
<212>  PRT
<213>  Streptococcus pyogenes

<400>  6

Met Ser Asn Lys Lys Thr Phe Lys Lys Tyr Ser Arg Val Ala Gly Leu 
1               5                   10                  15      


Leu Thr Ala Ala Leu Ile Ile Gly Asn Leu Val Thr Ala Asn Ala Glu 
            20                  25                  30          


Ser Asn Lys Gln Asn Thr Ala Ser Thr Glu Thr Thr Thr Thr Asn Glu 
        35                  40                  45              


Gln Pro Lys Pro Glu Ser Ser Glu Leu Thr Thr Glu Lys Ala Gly Gln 
    50                  55                  60                  


Lys Thr Asp Asp Met Leu Asn Ser Asn Asp Met Ile Lys Leu Ala Pro 
65                  70                  75                  80  


Lys Glu Met Pro Leu Glu Ser Ala Glu Lys Glu Glu Lys Lys Ser Glu 
                85                  90                  95      


Asp Lys Lys Lys Ser Glu Glu Asp His Thr Glu Glu Ile Asn Asp Lys 
            100                 105                 110         


Ile Tyr Ser Leu Asn Tyr Asn Glu Leu Glu Val Leu Ala Lys Asn Gly 
        115                 120                 125             


Glu Thr Ile Glu Asn Phe Val Pro Lys Glu Gly Val Lys Lys Ala Asp 
    130                 135                 140                 


Lys Phe Ile Val Ile Glu Arg Lys Lys Lys Asn Ile Asn Thr Thr Pro 
145                 150                 155                 160 


Val Asp Ile Ser Ile Ile Asp Ser Val Thr Asp Arg Thr Tyr Pro Ala 
                165                 170                 175     


Ala Leu Gln Leu Ala Asn Lys Gly Phe Thr Glu Asn Lys Pro Asp Ala 
            180                 185                 190         


Val Val Thr Lys Arg Asn Pro Gln Lys Ile His Ile Asp Leu Pro Gly 
        195                 200                 205             


Met Gly Asp Lys Ala Thr Val Glu Val Asn Asp Pro Thr Tyr Ala Asn 
    210                 215                 220                 


Val Ser Thr Ala Ile Asp Asn Leu Val Asn Gln Trp His Asp Asn Tyr 
225                 230                 235                 240 


Ser Gly Gly Asn Thr Leu Pro Ala Arg Thr Gln Tyr Thr Glu Ser Met 
                245                 250                 255     


Val Tyr Ser Lys Ser Gln Ile Glu Ala Ala Leu Asn Val Asn Ser Lys 
            260                 265                 270         


Ile Leu Asp Gly Thr Leu Gly Ile Asp Phe Lys Ser Ile Ser Lys Gly 
        275                 280                 285             


Glu Lys Lys Val Met Ile Ala Ala Tyr Lys Gln Ile Phe Tyr Thr Val 
    290                 295                 300                 


Ser Ala Asn Leu Pro Asn Asn Pro Ala Asp Val Phe Asp Lys Ser Val 
305                 310                 315                 320 


Thr Phe Lys Glu Leu Gln Arg Lys Gly Val Ser Asn Glu Ala Pro Pro 
                325                 330                 335     


Leu Phe Val Ser Asn Val Ala Tyr Gly Arg Thr Val Phe Val Lys Leu 
            340                 345                 350         


Glu Thr Ser Ser Lys Ser Asn Asp Val Glu Ala Ala Phe Ser Ala Ala 
        355                 360                 365             


Leu Lys Gly Thr Asp Val Lys Thr Asn Gly Lys Tyr Ser Asp Ile Leu 
    370                 375                 380                 


Glu Asn Ser Ser Phe Thr Ala Val Val Leu Gly Gly Asp Ala Ala Glu 
385                 390                 395                 400 


His Asn Lys Val Val Thr Lys Asp Phe Asp Val Ile Arg Asn Val Ile 
                405                 410                 415     


Lys Asp Asn Ala Thr Phe Ser Arg Lys Asn Pro Ala Tyr Pro Ile Ser 
            420                 425                 430         


Tyr Thr Ser Val Phe Leu Lys Asn Asn Lys Ile Ala Gly Val Asn Asn 
        435                 440                 445             


Arg Thr Glu Tyr Val Glu Thr Thr Ser Thr Glu Tyr Thr Ser Gly Lys 
    450                 455                 460                 


Ile Asn Leu Ser His Gln Gly Ala Tyr Val Ala Gln Tyr Glu Ile Leu 
465                 470                 475                 480 


Trp Asp Glu Ile Asn Tyr Asp Asp Lys Gly Lys Glu Val Ile Thr Lys 
                485                 490                 495     


Arg Arg Trp Asp Asn Asn Trp Tyr Ser Lys Thr Ser Pro Phe Ser Thr 
            500                 505                 510         


Val Ile Pro Leu Gly Ala Asn Ser Arg Asn Ile Arg Ile Met Ala Arg 
        515                 520                 525             


Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Lys Val Ile Asp Glu 
    530                 535                 540                 


Arg Asp Val Lys Leu Ser Lys Glu Ile Asn Val Asn Ile Ser Gly Ser 
545                 550                 555                 560 


Thr Leu Ser Pro Tyr Gly Ser Ile Thr Tyr Lys 
                565                 570     


<210>  7
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Non-toxic mutant of diphtheria toxin

<400>  7

Met Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu 
1               5                   10                  15      


Asn Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile 
            20                  25                  30          


Gln Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp 
        35                  40                  45              


Asp Asp Trp Lys Glu Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala 
    50                  55                  60                  


Gly Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly 
65                  70                  75                  80  


Val Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys 
                85                  90                  95      


Val Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr 
            100                 105                 110         


Glu Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe 
        115                 120                 125             


Gly Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly 
    130                 135                 140                 


Ser Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu 
145                 150                 155                 160 


Ser Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln 
                165                 170                 175     


Asp Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val 
            180                 185                 190         


Arg Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp 
        195                 200                 205             


Val Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His 
    210                 215                 220                 


Gly Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser 
225                 230                 235                 240 


Glu Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu 
                245                 250                 255     


Glu His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro 
            260                 265                 270         


Val Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln 
        275                 280                 285             


Val Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala 
    290                 295                 300                 


Leu Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly 
305                 310                 315                 320 


Ala Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu 
                325                 330                 335     


Ser Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val 
            340                 345                 350         


Asp Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu 
        355                 360                 365             


Phe Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly 
    370                 375                 380                 


His Lys Thr Gln Pro Phe Leu His Asp Gly Tyr Ala Val Ser Trp Asn 
385                 390                 395                 400 


Thr Val Glu Asp Ser Ile Ile Arg Thr Gly Phe Gln Gly Glu Ser Gly 
                405                 410                 415     


His Asp Ile Lys Ile Thr Ala Glu Asn Thr Pro Leu Pro Ile Ala Gly 
            420                 425                 430         


Val Leu Leu Pro Thr Ile Pro Gly Lys Leu Asp Val Asn Lys Ser Lys 
        435                 440                 445             


Thr His Ile Ser Val Asn Gly Arg Lys Ile Arg Met Arg Cys Arg Ala 
    450                 455                 460                 


Ile Asp Gly Asp Val Thr Phe Cys Arg Pro Lys Ser Pro Val Tyr Val 
465                 470                 475                 480 


Gly Asn Gly Val His Ala Asn Leu His Val Ala Phe His Arg Ser Ser 
                485                 490                 495     


Ser Glu Lys Ile His Ser Asn Glu Ile Ser Ser Asp Ser Ile Gly Val 
            500                 505                 510         


Leu Gly Tyr Gln Lys Thr Val Asp His Thr Lys Val Asn Ser Lys Leu 
        515                 520                 525             


Ser Leu Phe Phe Glu Ile Lys Ser 
    530                 535     


